MX336540B - Conjugados y anticuerpos manipulados geneticamente con cisteina. - Google Patents
Conjugados y anticuerpos manipulados geneticamente con cisteina.Info
- Publication number
- MX336540B MX336540B MX2012013868A MX2012013868A MX336540B MX 336540 B MX336540 B MX 336540B MX 2012013868 A MX2012013868 A MX 2012013868A MX 2012013868 A MX2012013868 A MX 2012013868A MX 336540 B MX336540 B MX 336540B
- Authority
- MX
- Mexico
- Prior art keywords
- cysteine engineered
- cysteine
- engineered antibodies
- antibody
- conjugates
- Prior art date
Links
- 235000018417 cysteine Nutrition 0.000 title abstract 8
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 title abstract 8
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 7
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- -1 free cysteine amino acid Chemical class 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- A61K47/6817—Toxins
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- C—CHEMISTRY; METALLURGY
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Abstract
La presente invención se refiere a los anticuerpos manipulados genéticamente con cisteína, que comprenden un aminoácido de cisteína libre en la cadena pesada o cadena ligera, y se preparan al mutagenizar una secuencia nucleoacídica de un anticuerpo parental y al sustituir uno o más residuos aminoacídicos por cisteína y codificar para el anticuerpo manipulado genéticamente con cisteína; la expresión del anticuerpo manipulado genéticamente con cisteína; y aislamiento del anticuerpo manipulado genéticamente con cisteína. Ciertos anticuerpos manipulados genéticamente con cisteína muy reactivos se identificaron mediante el ensayo por PHESELECTOR. Los anticuerpos aislados manipulados genéticamente con cisteína pueden unirse covalentemente a un marcador de captura, un marcador de detección, una porción del fármaco o a un soporte sólido.
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US35272810P | 2010-06-08 | 2010-06-08 | |
PCT/US2011/039386 WO2011156328A1 (en) | 2010-06-08 | 2011-06-07 | Cysteine engineered antibodies and conjugates |
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MX336540B true MX336540B (es) | 2016-01-22 |
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MX2012013868A MX336540B (es) | 2010-06-08 | 2011-06-07 | Conjugados y anticuerpos manipulados geneticamente con cisteina. |
MX2022006074A MX2022006074A (es) | 2010-06-08 | 2012-11-29 | Conjugados y anticuerpos manipulados geneticamente con cisteina. |
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MX2022006074A MX2022006074A (es) | 2010-06-08 | 2012-11-29 | Conjugados y anticuerpos manipulados geneticamente con cisteina. |
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US (4) | US9000130B2 (es) |
EP (1) | EP2579897A1 (es) |
JP (2) | JP2013534520A (es) |
KR (1) | KR101839163B1 (es) |
CN (3) | CN107335062B (es) |
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CA (2) | CA2799540A1 (es) |
MX (2) | MX336540B (es) |
RU (2) | RU2626537C2 (es) |
SG (2) | SG10201600791TA (es) |
WO (1) | WO2011156328A1 (es) |
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