MX336540B - Conjugados y anticuerpos manipulados geneticamente con cisteina. - Google Patents

Conjugados y anticuerpos manipulados geneticamente con cisteina.

Info

Publication number
MX336540B
MX336540B MX2012013868A MX2012013868A MX336540B MX 336540 B MX336540 B MX 336540B MX 2012013868 A MX2012013868 A MX 2012013868A MX 2012013868 A MX2012013868 A MX 2012013868A MX 336540 B MX336540 B MX 336540B
Authority
MX
Mexico
Prior art keywords
cysteine engineered
cysteine
engineered antibodies
antibody
conjugates
Prior art date
Application number
MX2012013868A
Other languages
English (en)
Other versions
MX2012013868A (es
Inventor
Sunil Bhakta
Jagath R Junutula
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2012013868A publication Critical patent/MX2012013868A/es
Publication of MX336540B publication Critical patent/MX336540B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/46—Hybrid immunoglobulins
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Abstract

La presente invención se refiere a los anticuerpos manipulados genéticamente con cisteína, que comprenden un aminoácido de cisteína libre en la cadena pesada o cadena ligera, y se preparan al mutagenizar una secuencia nucleoacídica de un anticuerpo parental y al sustituir uno o más residuos aminoacídicos por cisteína y codificar para el anticuerpo manipulado genéticamente con cisteína; la expresión del anticuerpo manipulado genéticamente con cisteína; y aislamiento del anticuerpo manipulado genéticamente con cisteína. Ciertos anticuerpos manipulados genéticamente con cisteína muy reactivos se identificaron mediante el ensayo por PHESELECTOR. Los anticuerpos aislados manipulados genéticamente con cisteína pueden unirse covalentemente a un marcador de captura, un marcador de detección, una porción del fármaco o a un soporte sólido.
MX2012013868A 2010-06-08 2011-06-07 Conjugados y anticuerpos manipulados geneticamente con cisteina. MX336540B (es)

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US35272810P 2010-06-08 2010-06-08
PCT/US2011/039386 WO2011156328A1 (en) 2010-06-08 2011-06-07 Cysteine engineered antibodies and conjugates

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