WO2003025138A2 - Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer - Google Patents

Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer Download PDF

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Publication number
WO2003025138A2
WO2003025138A2 PCT/US2002/029560 US0229560W WO03025138A2 WO 2003025138 A2 WO2003025138 A2 WO 2003025138A2 US 0229560 W US0229560 W US 0229560W WO 03025138 A2 WO03025138 A2 WO 03025138A2
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cancer
protein
sequence
nucleic acid
cell
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PCT/US2002/029560
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French (fr)
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WO2003025138A3 (en
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Daniel Afar
Natasha Aziz
Kurt C. Gish
Peter A. Hevezi
David H. Mack
Keith E. Wilson
Albert Zlotnik
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Protein Design Labs, Inc.
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Priority to AU2002330039A priority Critical patent/AU2002330039A1/en
Priority to CA002459219A priority patent/CA2459219A1/en
Priority to EP02766297A priority patent/EP1434881A4/en
Priority to JP2003529912A priority patent/JP2005518782A/en
Publication of WO2003025138A2 publication Critical patent/WO2003025138A2/en
Publication of WO2003025138A3 publication Critical patent/WO2003025138A3/en

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57449Specifically defined cancers of ovaries
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Definitions

  • the invention relates to the identification of nucleic acid and protein expression profiles and nucleic acids, products, and antibodies thereto that are involved in cancer; and to the use of such expression profiles and compositions in the diagnosis, prognosis, and therapy of cancer.
  • the invention further relates to methods for identifying and using agents and/or targets that modulate cancer.
  • Cancers share the charactaristic of disordered control over normal cell division, growth, and differentiation. Their initial clinical manifestations are extremely heterogeneous, with over 70 types of cancer arising in virtually every organ and tissue of the body. Moreover, some of those similarly classified cancer types may represent multiple different molecular diseases. Unfortunately, some cancers may be virtually asymptomatic until late in the disease course, when treatment is more difficult, and prognosis grim. Treatment for cancer typically includes surgery, chemotherapy, and/or radiation therapy. Although nearly 50 percent of cancer patients can be effectively treated using these methods, the current therapies all induce serious side effects which diminish quality of life. The identification of novel therapeutic targets and diagnostic markers will be important for improving the diagnosis and treatment of cancer patients.
  • Antigens suitable for immunotherapeutic strategies should be highly expressed in cancer tissues, preferably accessible from the vasculature and at the cell surface, and ideally not expressed in normal adult tissues. Expression in tissues that are dispensable for life, however, may be tolerated, e.g., reproductive organs.
  • Examples of antigens that are currently available for the detection and treatment of certain cancers include Her2/neu and the B-cell antigen CD20. Humanized monclonal antibodies directed to Her2/neu (Herceptin®/trastuzumab) are currently in use for the treatment of metastatic breast cancer.
  • anti-CD20 monoclonal antibodies are used to effectively treat non-Hodgkin's lymphoma. See Maloney, et al. (1997) Blood 90:2188-2195; Leget and Czuczman (1998) Curr. Opin. Oncol. 10:548-551.
  • provided herein are molecular targets for therapeutic intervention in various defined cancers. Additionally, provided herein are methods that can be used in diagnosis and prognosis of cancer. Further provided are methods that can be used to screen candidate bioactive agents for the ability to modulate cancer.
  • the present invention provides methods for determining the presence or absence of a pathological cell in a patient, the method comprising detecting a nucleic acid comprising a sequence at least 80% identical to a sequence as described in Tables 2 A-68 in a biological sample from the patient, thereby determining the presence or absence of the pathological cell.
  • the pathology is described in Table 1, including a cancer;
  • the biological sample comprises isolated nucleic acids;
  • the nucleic acids are mRNA;
  • the biological sample is tissue from an organ which is affected by the pathology of Table 1, including a cancer;
  • a further step is used of amplifying nucleic acids before the step of detecting the nucleic acid;
  • the detecting is of a protein encoded by the nucleic acid;
  • the nucleic acid comprises a sequence as described in Tables 2A-68;
  • the detecting step is carried out by using a labeled nucleic acid probe, utilizing a biochip comprising at sequence at least 80% identical to a sequence as described in Tables 2A-68, or detecting a polypeptide encoded by the nucleic acid; or the patient is undergoing a therapeutic regimen to treat the pathology of Table 1 , or is suspected of having the pathology or cancer.
  • Compostions are also provided, e.g., an isolated nucleic acid molecule comprising a sequence as described in Tables 2A-68, including, e.g., those which are labeled; an expression vector comprising such nucleic acid; a host cell comprising such expression vector; an isolated polypeptide which is encoded by such a nucleic acid molecule comprising a sequence as described in Tables 2A-68; or an antibody that specifically binds the polypeptide.
  • the antibody is: conjugated to an effector component, is conjugated to a detectable label (including, e.g., a fluorescent label, a radioisotope, or a cytotoxic chemical), an antibody fragment, or is a humanized antibody.
  • Additional methods are provided, including methods for specifically targeting a compound to a pathological cell in a patient, the method comprising administering to the patient an antibody, as described, thereby providing the targetting.
  • Others include, e.g., methods for determining the presence or absence of a pathological cell in a patient, the methods comprising contacting a biological sample with an antibody, as described.
  • the antibody is: conjugated to an effector component, or to a fluorescent label; or the biological sample is a blood, serum, urine, or stool sample.
  • Further methods include those for identifying a compound that modulates a pathology- associated polypeptide, the method comprising steps of: contacting the compound with a pathology-associated polypeptide, the polypeptide encoded by a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as described in Tables 2A-68; and determining the functional effect of the compound upon the polypeptide.
  • Another drug screening assay method comprises steps of: administering a test compound to a mammal having a pathology of Table 1 or a cell isolated therefrom; and comparing the level of gene expression of a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as described in Tables 2A-68 in a treated cell or mammal with the level of gene expression of the polynucleotide in a control cell or mammal, wherein a test compound that modulates the level of expression of the polynucleotide is a candidate for the treatment of the pathology.
  • the present invention provides novel methods for diagnosis and prognosis evaluation for various disorders, e.g., angiogenesis, fibrosis, and various defined forms of cancer, including metastatic cancer, as well as methods for screening for compositions which modulate such conditions. Also provided are methods for treating such disorders or cancers. See, e.g., American Society of Clinical Oncology (ed. 2001) ASCO Curriculum: Symptom Management Kendall/Hunt, ISBN: 0787277851; Bonadonna, et al. (2001) Textbook of Breast Cancer (2d ed.) Dunitz Martin, ISBN: 1853178241; Devita and Hellman (eds. 2001) Cancer Principles and Practice of Oncology (2 vols.), Lippincott Williams, ISBN: 0781723876; Howell, et al. (2001) Breast Cancer Isis Medical Media, ISBN:
  • identification of markers selectively expressed on defined cancers allows for use of that expression in diagnostic, prognostic, or therapeutic methods.
  • the invention defines various compositions, e.g., nucleic acids, polypeptides, antibodies, and small molecule agonists/antagonists, which will be useful to selectively identify those markers.
  • therapeutic methods may take the form of protein therapeutics which use the marker expression for selective localization or modulation of function (for those markers which have a causative disease effect), for vaccines, identification of binding partners, or antagonism, e.g., using antisense or RNAi.
  • the markers may be useful for molecular characterization of subsets of the diseases, e.g., as provided in Table 1, which subsets may actually require very different treatments. Moreover, the markers may also be important in related diseases to the specific disorders and cancers, e.g., which affect similar tissues in non-malignant diseases, or have similar mechanisms of induction/maintenance. Metastatic processes or characteristics may also be targeted. Diagnostic and prognostic uses are made available, e.g., to subset related but distinct diseases, or to determine treatment strategy. The detection methods may be based upon nucleic acid, e.g., PCR or hybridization techniques, or protein, e.g., ELISA, imaging, IHC, etc. The diagnosis may be qualitative or quantitative, and may detect increases or decreases in expression levels.
  • Tables 2B-66C provide unigene cluster identification numbers for the nucleotide sequence of genes that exhibit increased or decreased expression in cancer samples, particularly sequences involved in angiogenisis, prostate cancer (including androgen independent and taxol resistant prostate cancer), breast cancer, colorectal cancer, cervical cancer, bladder cancer, lung cancer, ovarian cancer, uterine cancer, glioblastoma, Ewing sarcoma, and lung fibrosis.
  • Tables 2A-67 also provide an exemplar accession number that provides a nucleotide sequence that is part of the unigene cluster. Definitions
  • cancer protein or “cancer polynucleotide” or “cancer-associated transcript” refers to nucleic acid and polypeptide polymorphic variants, alleles, mutants, and interspecies homologues that: (1) have a nucleotide sequence that has greater than about 60% nucleotide sequence identity, 65%, 70%, 75%, 80%, 85%, 90%, preferably about 92%, 94%, 96%, 97%, 98%, or 99% or greater nucleotide sequence identity, preferably over a region of over a region of at least about 25, 50, 100, 200, 500, 1000, or more nucleotides, to a nucleotide sequence of or associated with a gene of Tables 1-68; (2) bind to antibodies, e.g., polyclonal antibodies, raised against an immunogen comprising an amino acid sequence encoded by a nucleotide sequence of or associated with a gene of Tables 1-68, and conservatively modified variants thereof; (3) specifically hybridize under stringent
  • a polynucleotide or polypeptide sequence is typically from a mammal including, but not limited to, primate, e.g., human; rodent, e.g., rat, mouse, hamster; cow, pig, horse, sheep, or other mammal.
  • primate e.g., human
  • rodent e.g., rat, mouse, hamster
  • a “cancer polypeptide” and a “cancer polynucleotide,” include both naturally occurring or recombinant forms.
  • a “full length” cancer protein or nucleic acid refers to a cancer polypeptide or polynucleotide sequence, or a variant thereof, that contains elements normally contained in one or more naturally occurring, wild type cancer polynucleotide or polypeptide sequences.
  • the “full length” may be prior to, or after, various stages of post-translational processing or splicing, including alternative splicing.
  • Bio sample as used herein is a sample of biological tissue or fluid that contains nucleic acids or polypeptides, e.g., of a cancer protein, polynucleotide, or transcript. Such samples include, but are not limited to, tissue isolated from primates, e.g., humans, or rodents, e.g., mice, and rats. Biological samples may also include sections of tissues such as biopsy and autopsy samples, frozen sections taken for histologic purposes, archival samples, blood, plasma, serum, sputum, stool, tears, mucus, hair, skin, etc. Biological samples also include explants and primary and/or transformed cell cultures derived from patient tissues.
  • a biological sample is typically obtained from a eukaryotic organism, most preferably a mammal such as a primate e.g., chimpanzee or human; cow; dog; cat; a rodent, e.g., guinea pig, rat, mouse; rabbit; or a bird; reptile; or fish. Livestock and domestic animals are of interest.
  • Providing a biological sample means to obtain a biological sample for use in methods described in this invention. Most often, this will be done by removing a sample of cells from an animal, but can also be accomplished by using previously isolated cells (e.g., isolated by another person, at another time, and/or for another purpose), or by performing the methods of the invention in vivo. Archival tissues or materials, having treatment or outcome history, will be particularly useful.
  • nucleic acids or polypeptide sequences refer to two or more sequences or subsequences that are the same or have a specified percentage of amino acid residues or nucleotides that are the same (e.g., about 70% identity, preferably 75%, 80%, 85%, 90%, 91%, 93%, 95%, 97%, 98%, 99%, or higher identity over a specified region, when compared and aligned for maximum correspondence over a comparison window or designated region) as measured using, e.g., a BLAST or BLAST 2.0 sequence comparison algorithms with default parameters described below, or by manual alignment and visual inspection (see, e.g., NCBI web site http://www.ncbi.nlm.nih.gov/BLAST/ or the like).
  • sequences are then said to be “substantially identical.”
  • This definition also refers to, or may be applied to, the complement of a test sequence.
  • the definition also includes sequences that have deletions and/or insertions, substitutions, and naturally occurring, e.g., polymorphic or allelic variants, and man-made variants.
  • the preferred algorithms can account for gaps and the like.
  • identity exists over a region that is at least about 25 amino acids or nucleotides in length, or more preferably over a region that is 50- 100 amino acids or nucleotides in length.
  • For sequence comparison typically one sequence acts as a reference sequence, to which test sequences are compared.
  • test and reference sequences are entered into a computer, subsequence coordinates are designated, if necessary, and sequence algorithm program parameters are designated. Preferably, default program parameters can be used, or alternative parameters can be designated.
  • sequence comparison algorithm then calculates the percent sequence identities for the test sequences relative to the reference sequence, based on the program parameters.
  • a “comparison window”, as used herein, includes reference to a segment of contiguous positions selected from the group consisting typically of from 20 to 600, usually about 50 to about 200, more usually about 100 to about 150, in which a sequence may be compared to a reference sequence of the same number of contiguous positions after the two sequences are optimally aligned.
  • Methods of alignment of sequences for comparison are well-known. Optimal alignment of sequences for comparison can be conducted, e.g., by the local homology algorithm of Smith and Waterman (1981) Adv. Appl. Math. 2:482-489, by the homology alignment algorithm of Needleman and Wunsch (1970) J. Mol. Biol.
  • BLAST and BLAST 2.0 are used, with the parameters described herein, to determine percent sequence identity for the nucleic acids and proteins of the invention.
  • Software for performing BLAST analyses is publicly available through the National Center for Biotechnology Information (http://www.ncbi.nlm.nih.gov/).
  • This algorithm involves first identifying high scoring sequence pairs (HSPs) by identifying short words of length W in the query sequence, which either match or satisfy some positive-valued threshold score T when aligned with a word of the same length in a database sequence. T is referred to as the neighborhood word score threshold (Altschul, et al., supra). These initial neighborhood word hits act as seeds for initiating searches to find longer HSPs containing them.
  • HSPs high scoring sequence pairs
  • the word hits are extended in both directions along each sequence for as far as the cumulative alignment score can be increased.
  • -Cumulative scores are calculated using, e.g., for nucleotide sequences, the parameters M (reward score for a pair of matching residues; always > 0) and N (penalty score for mismatching residues; always ⁇ 0).
  • M forward score for a pair of matching residues; always > 0
  • N penalty score for mismatching residues; always ⁇ 0
  • a scoring matrix is used to calculate the cumulative score.
  • Extension of the word hits in each direction are halted when: the cumulative alignment score falls off by the quantity X from its maximum achieved value; the cumulative score goes to zero or below, due to the accumulation of one or more negative- scoring residue alignments; or the end of either sequence is reached.
  • the BLAST algorithm parameters W, T, and X determine the sensitivity and speed of the alignment.
  • the BLAST algorithm also performs a statistical analysis of the similarity between two sequences. See, e.g., Karlin and Altschul (1993) Proc. Nat'l. Acad. Sci. USA 90:5873-5787.
  • One measure of similarity provided by the BLAST algorithm is the smallest sum probability (P(N)), which provides an indication of the probability by which a match between two nucleotide or amino acid sequences would occur by chance.
  • P(N) the smallest sum probability
  • a nucleic acid is considered similar to a reference sequence if the smallest sum probability in a comparison of the test nucleic acid to the reference nucleic acid is less than about 0.2, more preferably less than about ⁇ .01, and most preferably less than about 0.001.
  • Log values may be negative large numbers, e.g., 5, 10, 20, 30, 40, 40, 70, 90, 110, 150, 170, etc.
  • nucleic acid sequences are substantially identical.
  • a polypeptide is typically substantially identical to a second polypeptide, e.g., where the two peptides differ only by conservative substitutions.
  • Another indication that two nucleic acid sequences are substantially identical is that the two molecules or their complements hybridize to each other under stringent conditions.
  • Yet another indication that two nucleic acid sequences are substantially identical is that the same primers can be used to amplify the sequences.
  • a "host cell” is a naturally occurring cell or a transformed cell that contains an expression vector and supports the replication or expression of the expression vector.
  • Host cells may be cultured cells, explants, cells in vivo, and the like.
  • Host cells may be prokaryotic cells such as E. coli, or eukaryotic cells such as yeast, insect, amphibian, or mammalian cells such as CHO, HeLa, and the like (see, e.g., the American Type Culture Collection catalog or web site, www.atcc.org).
  • isolated refers to material that is substantially or essentially free from components that normally accompany it as found in its native state. Purity and homogeneity are typically determined using analytical chemistry techniques such as polyacrylamide gel electrophoresis or high performance liquid chromatography. A protein or nucleic acid that is the predominant species present in a preparation is substantially purified. In particular, an isolated nucleic acid is separated from some open reading frames that naturally flank the gene and encode proteins other than protein encoded by the gene.
  • purified in some embodiments denotes that a nucleic acid or protein gives rise to essentially one band in an electrophoretic gel.
  • nucleic acid or protein is at least about 85% pure, more preferably at least 95% pure, and most preferably at least 99% pure.
  • “Purify” or “purification” in other embodiments means removing at least one contaminant or component from the composition to be purified. In this sense, purification does not require that the purified compound be homogeneous, e.g., 100% pure.
  • polypeptide polypeptide
  • peptide and “protein” are used interchangeably herein to refer to a polymer of amino acid residues. The terms apply to amino acid polymers in which one or more amino acid residue is an artificial chemical mimetic of a corresponding naturally occurring amino acid, as well as to naturally occurring amino acid polymers, those containing modified residues, and non-naturally occurring amino acid polymers.
  • amino acid refers to naturally occurring and synthetic amino acids, as well as amino acid analogs and amino acid mimetics that function similarly to the naturally occurring amino acids.
  • Naturally occurring amino acids are those encoded by the genetic code, as well as those amino acids that are later modified, e.g., hydroxyproline, ⁇ -carboxyglutamate, and O- phosphoserine.
  • Amino acid analogs refers to compounds that have the same basic chemical structure as a naturally occurring amino acid, e.g., an carbon that is bound to a hydrogen, a carboxyl group, an amino group, and an R group, e.g., homoserine, norleucine, methionine sulfoxide, methionine methyl sulfonium.
  • Such analogs may have modified R groups (e.g., norleucine) or modified peptide backbones, but retain somebasic chemical structure as a naturally occurring amino acid.
  • Amino acid mimetic refers to a chemical compound that has a structure that is different from the general chemical structure of an amino acid, but that functions similarly to another amino acid.
  • Constantly modified variant applies to both amino acid and nucleic acid sequences.
  • conservatively modified variants refers to those nucleic acids which encode identical or essentially identical amino acid sequences, or where the nucleic acid does not encode an amino acid sequence, to essentially identical or associated, e.g., naturally contiguous, sequences.
  • the codons GCA, GCC, GCG, and GCU each encode the amino acid alanine.
  • nucleic acid variations are "silent variations," which are one species of conservatively modified variations.
  • Every nucleic acid sequence herein which encodes a polypeptide also describes silent variations of the nucleic acid.
  • each codon in a nucleic acid except AUG, which is ordinarily the only codon for methionine, and TGG, which is ordinarily the only codon for tryptophan
  • TGG which is ordinarily the only codon for tryptophan
  • amino acid sequences one of skill will recognize that individual substitutions, deletions, or additions to a nucleic acid, peptide, polypeptide, or protein sequence which alters, adds, or deletes a single amino acid or a small percentage of amino acids in the encoded sequence is a "conservatively modified variant" where the alteration results in the substitution of an amino acid with a chemically similar amino acid. Conservative substitution tables providing functionally similar amino acids are well known. Such conservatively modified variants are in addition to and do not exclude polymorphic variants, interspecies homologs, and alleles of the invention.
  • conservative substitutions include for one another: 1) Alanine (A), Glycine (G); 2) Aspartic acid (D), Glutamic acid (E); 3) Asparagine (N), Glutamine (Q); 4) Arginine (R), Lysine (K); 5) Isoleucine (I), Leucine (L), Methionine (M), Valine (V); 6) Phenylalanine (F), Tyrosine (Y), Tryptophan (W); 7) Serine (S), Threonine (T); and 8) Cysteine (C), Methionine (M) (see, e.g., Creighton (1984) Proteins: Structure and Molecular Properties Freeman).
  • Macromolecular structures such as polypeptide structures can be described in terms of various levels of organization. For a general discussion of this organization, see, e.g., Alberts, et al. (eds. 2001) Molecular Biology of the Cell (4th ed.) Garland; and Cantor and Schimmel (1980) Biophysical Chemistry Part I: The Conformation of Biological Macromolecules Freeman.
  • Primary structure refers to the amino acid sequence of a particular peptide.
  • “Secondary structure” refers to locally ordered, three dimensional structures within a polypeptide. These structures are commonly known as domains. Domains are portions of a polypeptide that often form a compact unit of the polypeptide and are typically 25 to approximately 500 amino acids long.
  • Typical domains are made up of sections of lesser organization such as stretches of ⁇ -sheet and ⁇ -helices.
  • Tetiary structure refers to the complete three dimensional structure of a polypeptide monomer.
  • Quaternary structure refers to the three dimensional structure formed, usually by the noncovalent association of independent tertiary units. Ariisotropic terms are also known as energy terms.
  • Nucleic acid or “oligonucleotide” or “polynucleotide” or grammatical equivalents used herein means at least two nucleotides covalently linked together. Oligonucleotides are typically from about 5, 6, 7, 8, 9, 10, 12, 15, 25, 30, 40, 50, or more nucleotides in length, up to about 100 nucleotides in length. Nucleic acids and polynucleotides are a polymers of any length, including longer lengths, e.g., 200, 300, 500, 1000, 2000, 3000, 5000, 7000, 10,000, etc.
  • a nucleic acid of the present invention will generally contain phosphodiester bonds, although in some cases, nucleic acid analogs are included that may have at least one different linkahge, e.g., phosphoramidate, phosphorothioate, phosphorodithioate, or O-methylphophoroamidite linkages (see Eckstein (1992) Oligonucleotides and Analogues: A Practical Approach Oxford Univ. Press); and peptide nucleic acid backbones and linkages.
  • Other analog nucleic acids include those with positive backbones; non-ionic backbones, and non-ribose backbones, including those described in U.S. Patent Nos.
  • nucleic acids containing one or more carbocyclic sugars are also included within one definition of nucleic acids. Modifications of the ribose-phosphate backbone may be done for a variety of reasons, e.g., to increase the stability and half-life of such molecules in physiological environments or as probes on a biochip. Mixtures of naturally occurring nucleic acids and analogs can be made; alternatively, mixtures of different nucleic acid analogs, and mixtures of naturally occurring nucleic acids and analogs may be made.
  • nucleic acid analogs including, e.g., phosphoramidate (Beaucage, et al. (1993) Tetrahedron 49:1925-1963 and references therein; Letsinger (1970) J. Org. Chem. 35:3800-3803; Sblul, et al. (1977) Eur. J. Biochem. 81:579- 589; Letsinger, et al. (1986) Nucl. Acids Res. 14:3487-499; Sawai, et al. (1984) Chem. Lett. 805, Letsinger, et al. (1988) J. Am. Chem. Soc.
  • Nucleic acids containing one or more carbocyclic sugars are also included within one definition of nucleic acids (see Jenkins, et al. (1995) Chem. Soc. Rev, pp 169-176).
  • nucleic acid analogs are described in Rawls (page 35, June 2, 1997) C&E News.
  • PNA peptide nucleic acids
  • These backbones are substantially non-ionic under neutral conditions, in contrast to the highly charged phosphodiester backbone of naturally occurring nucleic acids. This results in at least two advantages.
  • the PNA backbone exhibits improved hybridization kinetics.
  • PNAs have larger changes in the melting temperature (T m ) for mismatched versus perfectly matched basepairs.
  • DNA and RNA typically exhibit a 2-4° C drop in T m for an internal mismatch.
  • the drop is closer to 7-9° C.
  • hybridization of the bases attached to these backbones is relatively insensitive to salt concentration.
  • PNAs are not degraded by cellular enzymes, and thus can be more stable.
  • the nucleic acids may be single stranded or double stranded, as specified, or contain portions of both double stranded or single stranded sequence.
  • the depiction of a single strand also defines the sequence of the complementary strand; thus the sequences described herein also provide the complement of the sequence.
  • the nucleic acid may be DNA, both genomic and cDNA, RNA, or a hybrid, where the nucleic acid may contain combinations of deoxyribo- and ribo-nucleotides, and combinations of bases, including uracil, adenine, thymine, cytosine, guanine, inosine, xanthine hypoxanthine, isocytosine, isoguanine, etc.
  • Transcript typically refers to a naturally occurring RNA, e.g., a pre-mRNA, hnRNA, or mRNA.
  • nucleoside includes nucleotides and nucleoside and nucleotide analogs, and modified nucleosides such as amino modified nucleosides.
  • nucleoside includes non- naturally occurring analog structures. Thus, e.g., the individual units of a peptide nucleic acid, each containing a base, are refened to herein as a nucleoside.
  • a “label” or a “detectable moiety” is a composition detectable by spectroscopic, photochemical, biochemical, immunochemical, physiological, chemical, or other physical means.
  • labels fall into three classes: a) isotopic labels, which may be radioactive or heavy isotopes; b) immune labels, which may be antibodies, antigens, or epitope tags; and c) colored or fluorescent dyes.
  • the labels may be incorporated into the cancer nucleic acids, proteins, and antibodies.
  • the label should be capable of producing, either directly or indirectly, a detectable signal.
  • the detectable moiety may be a radioisotope, such as ⁇ H, l ⁇ C, 32p 5 35g 5 or 125j 5 electron-dense reagents, a fluorescent or chemiluminescent compound, such as fluorescein isothiocyanate, rhodamine, or luciferin, or an enzyme (e.g., as commonly used in an ELISA), biotin, digoxigenin, or haptens and proteins or other entities which can be made detectable such as alkaline phosphatase, beta-galactosidase, or horseradish peroxidase. Methods are known for conjugating the antibody to the label. See, e.g., Hunter, et al.
  • effector or “effector moiety” or “effector component” is a molecule that is bound (or linked, or conjugated), either covalently, through a linker or a chemical bond, or noncovalently, through ionic, van der Waals, electrostatic, or hydrogen bonds, to an antibody.
  • the "effector” can be a variety of molecules including, e.g., detection moieties including radioactive compounds, fluorescent compounds, enzymes or substrates, tags such as epitope tags, toxins; activatable moieties, chemotherapeutic agents; lipases; antibiotics; or radioisotopes, e.g., emitting "hard” beta, radiation.
  • a "labeled nucleic acid probe or oligonucleotide” is one that is bound, e.g., covalently, through a linker or a chemical bond, or noncovalently, through ionic, van der Waals, electrostatic, or hydrogen bonds to a label such that the presence of the probe may be detected by detecting the presence of the label bound to the probe.
  • methods using high affinity interactions may achieve the same results where one of a pair of binding partners binds to the other, e.g., biotin, streptavidin.
  • nucleic acid probe or oligonucleotide is a nucleic acid capable of binding to a target nucleic acid of complementary sequence through one or more types of chemical bonds, usually through complementary base pairing, e.g., through hydrogen bond formation.
  • a probe may include natural (e.g., A, G, C, or T) or modified bases (7-deazaguanosine, inosine, etc.).
  • the bases in a probe may be joined by a linkage other than a phosphodiester bond, preferably one that does not functionally interfere with hybridization.
  • probes may be peptide nucleic acids in which the constituent bases are joined by peptide bonds rather than phosphodiester linkages. Probes may bind target sequences lacking complete complementarity with the probe sequence depending upon the stringency of the hybridization conditions.
  • the probes are preferably directly labeled, e.g., with isotopes, chromophores, lumiphores, chromogens, or indirectly labeled, e.g., with biotin to which a streptavidin complex may later bind. By assaying for the presence or absence of the probe, one can detect the presence or absence of the select sequence or subsequence.
  • Diagnosis or prognosis may be based at the genomic level, or at the level of RNA or protein expression.
  • the term "recombinant" when used with reference, e.g., to a cell, or nucleic acid, protein, or vector, indicates that the cell, nucleic acid, protein, or vector, has been modified by the introduction of a heterologous nucleic acid or protein or the alteration of a native nucleic acid or protein, or that the cell is derived from a cell so modified.
  • recombinant cells express genes that are not found within the native (non-recombinant) form of the cell or express native genes that are otherwise abnormally expressed, under expressed, or not expressed at all.
  • nucleic acid By the term “recombinant nucleic acid” herein is meant nucleic acid, originally formed in vitro, in general, by the manipulation of nucleic acid, e.g., using polymerases and endonucleases, in a form not noraially found in nature. In this manner, operably linkage of different sequences is achieved.
  • an isolated nucleic acid, in a linear form, or an expression vector formed in vitro by ligating DNA molecules that are not normally joined are both considered recombinant for the purposes of this invention.
  • nucleic acid once a recombinant nucleic acid is made and reintroduced into a host cell or organism, it will replicate non-recombinantly, e.g., using the in vivo cellular machinery of the host cell rather than in vitro manipulations; however, such nucleic acids, once produced recombinantly, although subsequently replicated non- recombinantly, are still considered recombinant for the purposes of the invention.
  • a "recombinant protein” is a protein made using recombinant techniques, e.g., through the expression of a recombinant nucleic acid as depicted above.
  • a recombinant protein is distinguished from naturally occurring protein by at least one or more characteristics.
  • the protein may be isolated or purified away from some or most of the proteins and compounds with which it is normally associated in its wild type host, and thus may be substantially pure.
  • An isolated protein is unaccompanied by at least some of the material with which it is normally associated in its natural state, preferably constituting at least about 0.5%, more preferably at least about 5% by weight of the total protein in a given sample.
  • a substantially pure protein comprises at least about 75% by weight of the total protein, with at least about 80% being prefened, and at least about 90% being particularly prefened.
  • the definition includes the production of a skin cancer protein from one organism in a different organism or host cell.
  • the protein may be made at a significantly higher concentration than is normally seen, through the use of an inducible promoter or high expression promoter, such that the protein is made at increased concentration levels.
  • the protein may be in a form not normally found in nature, as in the addition of an epitope tag or amino acid substitutions, insertions and deletions, as discussed below.
  • heterologous when used with reference to portions of a nucleic acid indicates that the nucleic acid comprises two or more subsequences that are not normally found in the same relationship to each other in nature.
  • the nucleic acid is typically recombinantly produced, having two or more sequences, e.g., from unrelated genes arranged to make a new functional nucleic acid, e.g., a promoter from one source and a coding region from another source.
  • a heterologous protein will often refer to two or more subsequences that are not found in the same relationship to each other in nature (e.g., a fusion protein).
  • a “promoter” is typically an anay of nucleic acid control sequences that direct transcription of a nucleic acid.
  • a promoter includes necessary nucleic acid sequences near the start site of transcription, such as, in the case of a polymerase II type promoter, a TATA element.
  • a promoter also optionally includes distal enhancer or repressor elements, which can be located as much as several thousand base pairs from the start site of transcription.
  • a “constitutive” promoter is a promoter that is active under most environmental and developmental conditions.
  • An “inducible” promoter is a promoter that is active under environmental or developmental regulation.
  • operably linked refers to a functional linkage between a nucleic acid expression control sequence (such as a promoter, or anay of transcription factor binding sites) and a second nucleic acid sequence, e.g., wherein the expression control sequence directs transcription of the nucleic acid conesponding to the second sequence.
  • a nucleic acid expression control sequence such as a promoter, or anay of transcription factor binding sites
  • an "expression vector” is a nucleic acid construct, generated recombinantly or synthetically, with a series of specified nucleic acid elements that permit transcription of a particular nucleic acid in a host cell.
  • the expression vector can be part of a plasmid, virus, or nucleic acid fragment.
  • the expression vector includes a nucleic acid to be transcribed in operable linkage to a promoter.
  • sequenceselectively (or specifically) hybridizes to refers to the binding, duplexing, or hybridizing of a molecule selectively to a particular nucleotide sequence under stringent hybridization conditions when that sequence is present in a complex mixture (e.g., total cellular or library DNA or RNA).
  • stringent hybridization conditions refers to conditions under which a probe will hybridize to its target subsequence, typically in a complex mixture of nucleic acids, but to no other sequences. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridize specifically at higher temperatures.
  • T m thermal melting point
  • Stringent conditions will be those in which the salt concentration is less than about 1.0 M sodium ion, typically about 0.01-1.0 M sodium ion concentration (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30° C for short probes (e.g., about 10-50 nucleotides) and at least about 60° C for long probes (e.g., greater than about 50 nucleotides). Stringent conditions may also be achieved with the addition of destabilizing agents such as formamide. For selective or specific hybridization, a positive signal is typically at least two times background, preferably 10 times background hybridization.
  • Exemplary stringent hybridization conditions can be as following: 50% formamide, 5x SSC, and 1% SDS, incubating at 42° C, or, 5x SSC, 1% SDS, incubating at 65° C, with wash in 0.2x SSC, and 0.1% SDS at 65° C.
  • a temperature of about 36° C is typical for low stringency amplification, although annealing temperatures may vary between about 32°-48° C depending on primer length.
  • a temperature of about 62° C is typical, although high stringency annealing temperatures can range from about 50-65° C, depending on the primer length and specificity.
  • Typical cycle conditions for both high and low stringency amplifications include a denaturation phase of 90-95° C for 30-120 sec, an annealing phase lasting 30-120 sec, and an extension phase of about 72° C for 1-2 min. Protocols and guidelines for low and high stringency amplification reactions are provided, e.g., in Innis, et al. (1990) PCR Protocols: A Guide to Methods and Applications, Academic Press, NY.
  • Nucleic acids that do not hybridize to each other under stringent conditions are still substantially identical if the polypeptides which they encode are substantially identical. This occurs, e.g., when a copy of a nucleic acid is created using the maximum codon degeneracy permitted by the genetic code. In such cases, the nucleic acids typically hybridize under moderately stringent hybridization conditions.
  • Exemplary "moderately stringent hybridization conditions" include a hybridization in a buffer of 40% formamide, 1 M NaCl, 1% SDS at 37° C, and a wash in IX SSC at 45° C. A positive hybridization is typically at least twice background. Alternative hybridization and wash conditions can be utilized to provide conditions of similar stringency. Additional guidelines for determining hybridization parameters are provided in numerous references, e.g., Ausubel, et al. (eds. 1991 and supplements) Cunent Protocols in Molecular Biology Wiley.
  • the phrase "functional effects" in the context of assays for testing compounds that modulate activity of a cancer protein includes the determination of a parameter that is indirectly or directly under the influence of the cancer protein or nucleic acid, e.g., a physiological, functional, physical, or chemical effect, such as the ability to decrease cancer. It includes ligand binding activity; cell viability; cell growth on soft agar; anchorage dependence; contact inhibition and density limitation of growth; cellular proliferation; cellular transformation; growth factor or serum dependence; tumor specific marker levels; invasiveness into Matrigel; tumor growth and metastasis in vivo; mRNA and protein expression in cells undergoing metastasis; and other characteristics of cancer cells. "Functional effects” include in vitro, in vivo, and ex vivo activities.
  • determining the functional effect is meant assaying for a compound that increases or decreases a parameter that is indirectly or directly under the influence of a cancer protein sequence, e.g., physiological, functional, enzymatic, physical, or chemical effects.
  • Such functional effects can be measured, e.g., changes in spectroscopic characteristics (e.g., fluorescence, absorbance, refractive index), hydrodynamic (e.g., shape), chromatographic, or solubility properties for the protein, measuring inducible markers or transcriptional activation of the cancer protein, measuring binding activity or binding assays, e.g., binding to antibodies or other ligands, and measuring growth, cellular proliferation, cell viability, cellular transformation, growth factor or serum dependence, tumor specific marker levels, invasiveness into Matrigel, tumor growth and metastasis in vivo, mRNA and protein expression, and other characteristics of cancer cells.
  • spectroscopic characteristics e.g., fluorescence, absorbance, refractive index
  • hydrodynamic e.g
  • the functional effects can be evaluated by many means, e.g., microscopy for quantitative or qualitative measures of alterations in morphological features, measurement of changes in RNA or protein levels for cancer-associated sequences, measurement of RNA stability, identification of downstream or reporter gene expression (CAT, luciferase, -gal, GFP, and the like), e.g., via chemiluminescence, fluorescence, colorimetric reactions, antibody binding, inducible markers, and ligand binding assays.
  • microscopy for quantitative or qualitative measures of alterations in morphological features, measurement of changes in RNA or protein levels for cancer-associated sequences, measurement of RNA stability, identification of downstream or reporter gene expression (CAT, luciferase, -gal, GFP, and the like), e.g., via chemiluminescence, fluorescence, colorimetric reactions, antibody binding, inducible markers, and ligand binding assays.
  • Inhibitors are used to refer to activating, inhibitory, or modulating molecules or compounds identified using in vitro and in vivo assays of cancer polynucleotide and polypeptide sequences.
  • Inhibitors are compounds that, e.g., bind to, partially or totally block activity, decrease, prevent, delay activation, inactivate, desensitize, or down regulate the activity or expression of cancer proteins, e.g., antagonists.
  • Antisense or inhibitory nucleic acids may seem to inhibit expression and subsequent function of the protein.
  • Activators are compounds that increase, open, activate, facilitate, enhance activation, sensitize, agonize, or up regulate cancer protein activity.
  • Inhibitors, activators, or modulators also include genetically modified versions of cancer proteins, e.g., versions with altered activity, as well as naturally occurring and synthetic ligands, antagonists, agonists, antibodies, small chemical molecules, and the like.
  • Such assays for inhibitors and activators include, e.g., expressing the cancer protein in vitro, in cells, or cell membranes, applying putative modulator compounds, and then determining the functional effects on activity, as described above.
  • Activators and inhibitors of cancer can also be identified by incubating cancer cells with the test compound and determining increases or decreases in the expression of 1 or more cancer proteins, e.g., 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 40, 50, or more cancer proteins, such as cancer proteins encoded by the sequences set out in Tables 1-68.
  • 1 or more cancer proteins e.g., 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 40, 50, or more cancer proteins, such as cancer proteins encoded by the sequences set out in Tables 1-68.
  • Samples or assays comprising cancer proteins that are treated with a potential activator, inhibitor, or modulator are compared to control samples without the inhibitor, activator, or modulator to examine the extent of inhibition.
  • Control samples (untreated with inhibitors) are assigned a relative protein activity value of 100%. Inhibition of a polypeptide is achieved when the activity value relative to the control is about 80%, preferably 50%, more preferably 25-0%.
  • Activation of a cancer polypeptide is achieved when the activity value relative to the control (untreated with activators) is 110%, more preferably 150%, more preferably 200-500% (e.g., two to five fold higher relative to the control), more preferably 1000-3000% higher.
  • change in cell growth refers to any change in cell growth and proliferation characteristics in vitro or in vivo, such as cell viability, formation of foci, anchorage independence, semi-solid or soft agar growth, changes in contact inhibition and density limitation of growth, loss of growth factor or serum requirements, changes in cell morphology, gaining or losing immortalization, gaining or losing tumor specific markers, ability to form or suppress tumors when injected into suitable animal hosts, and/or immortalization of the cell. See, e.g., pp. 231-241 in Freshney (1994) Culture of Animal Cells a Manual of Basic Technique (2d ed.) Wiley-Liss. "Tumor cell” refers to precancerous, cancerous, and normal cells in a tumor.
  • “Cancer cells,” “transformed” cells or “transformation” in tissue culture refers to spontaneous or induced phenotypic changes that do not necessarily involve the uptake of new genetic material.
  • transformation can arise from infection with a transforming virus and incorporation of new genomic DNA, or uptake of exogenous DNA, it can also arise spontaneously or following exposure to a carcinogen, thereby mutating an endogenous gene. Transformation is associated with phenotypic changes, such as immortalization of cells, abenant growth control, nonmorphological changes, and/or malignancy. See, Freshney (2000) Culture of Animal Cells: A Manual of Basic Technique (4th ed.) Wiley-Liss.
  • Antibody refers to a polypeptide comprising a framework region from an immunoglobulin gene or fragments thereof that specifically binds and recognizes an antigen.
  • the recognized immunoglobulin genes include the kappa, lambda, alpha, gamma, delta, epsilon, and mu constant region genes, as well as the myriad immunoglobulin variable region genes.
  • Light chains are classified as either kappa or lambda.
  • Heavy chains are classified as gamma, mu, alpha, delta, or epsilon, which in turn define the immunoglobulin classes, IgG, IgM, IgA, IgD, and IgE, respectively.
  • the antigen-binding region of an antibody or its functional equivalent will be most critical in specificity and affinity of binding. See Paul (ed. 1999) Fundamental Immunology (4th ed.) Raven.
  • An exemplary immunoglobulin (antibody) structural unit comprises a tetramer.
  • Each tetramer is composed of two identical pairs of polypeptide chains, each pair having one "light” (about 25 D) and one "heavy” chain (about 50-70 kD).
  • the N-terminus of each chain defines a variable region of about 100 to 110 or more amino acids primarily responsible for antigen recognition.
  • the terms variable light chain (Vjj and variable heavy chain (VJJ) refer to these light and heavy chains respectively.
  • Antibodies exist, e.g., as intact immunoglobulins or as a number of well-characterized fragments produced by digestion with various peptidases.
  • pepsin digests an antibody below the disulfide linkages in the hinge region to produce F(ab)'2 a dimer of Fab which itself is a light chain joined to VJJ-CJJI by a disulfide bond.
  • the F(ab)'2 may be reduced under mild conditions to break the disulfide linkage in the hinge region, thereby converting the F(ab)'2 dimer into an Fab' monomer.
  • the Fab' monomer is essentially Fab with part of the hinge region (see Paul (ed.
  • antibody fragments are defined in terms of the digestion of an intact antibody, one of skill will appreciate that such fragments may be synthesized de novo either chemically or by using recombinant DNA methodology.
  • the term antibody also includes antibody fragments either produced by the modification of whole antibodies, or those synthesized de novo using recombinant DNA methodologies (e.g., single chain Fv) or those identified using phage display libraries (see, e.g., McCafferty, et al. (1990) Nature 348:552-554).
  • recombinant DNA methodologies e.g., single chain Fv
  • phage display libraries see, e.g., McCafferty, et al. (1990) Nature 348:552-554
  • a "chimeric antibody” is an antibody molecule in which (a) the constant region, or a portion thereof, is altered, replaced, or exchanged so that the antigen binding site (variable region) is linked to a constant region of a different or altered class, effector function, and/or species, or an entirely different molecule which confers new properties to the chimeric antibody, e.g., an enzyme, toxin, hormone, growth factor, drug, etc.; or (b) the variable region, or a portion thereof, is altered, replaced, or exchanged with a variable region having a different or altered antigen specificity.
  • the expression levels of genes are determined in different patient samples for which diagnosis information is desired, to provide expression profiles.
  • An expression profile of a particular sample is essentially a "fingerprint" of the state of the sample; while two states may have any particular gene similarly expressed, the evaluation of a number of genes simultaneously allows the generation of a gene expression profile that is characteristic of the state of the cell. That is, normal tissue may be distinguished from cancerous or metastatic cancerous tissue, or cancer tissue or metastatic cancerous tissue can be compared with tissue from surviving cancer patients. By comparing expression profiles of tissue in known different cancer states, information regarding which genes are important (including both up-and down- regulation of genes) in each of these states is obtained. Molecular profiling may distinguish subtypes of a cunently collective disease designation, e.g., different forms of a cancer.
  • sequences that are differentially expressed in cancer versus non- cancer tissue allows the use of this information in a number of ways. For example, a particular treatment regime may be evaluated: does a chemotherapeutic drug act to down-regulate cancer, and thus tumor growth or recunence, in a particular patient. Alternatively, a treatment step may induce other markers which may be used as targets to destroy tumor cells. Similarly, diagnosis and treatment outcomes may be done or confirmed by comparing patient samples with the known expression profiles. Maliganant disease may be compared to non-malignant conditions. Metastatic tissue can also be analyzed to determine the stage of cancer in the tissue, or origin of primary tumor, e.g., metastasis from a remote primary site.
  • these gene expression profiles allow screening of drug candidates with an eye to mimicking or altering a particular expression profile; e.g., screening can be done for drugs that suppress the cancer expression profile. This may be done by making biochips comprising sets of the important cancer genes, which can then be used in these screens. These methods can also be done on the protein basis; that is, protein expression levels of the cancer proteins can be evaluated for diagnostic purposes or to screen candidate agents.
  • the cancer nucleic acid sequences can be administered for gene therapy purposes, including the administration of antisense nucleic acids, or the cancer proteins (including antibodies and other modulators thereof) administered as therapeutic drugs.
  • cancer sequences include those that are up-regulated (e.g., expressed at a higher level) in cancer, as well as those that are down-regulated (e.g., expressed at a lower level).
  • the cancer sequences are from humans; however, cancer sequences from other organisms may be useful in animal models of disease and drug evaluation; thus, other cancer sequences are provided, from vertebrates, including mammals, including rodents (rats, mice, hamsters, guinea pigs, etc.), primates, farm animals (including sheep, goats, pigs, cows, horses, etc.) and pets (e.g., dogs, cats, etc.). Cancer sequences from other organisms may be obtained using the techniques outlined below.
  • Cancer sequences can include both nucleic acid and amino acid sequences.
  • the skin cancer sequences are recombinant nucleic acids. These nucleic acid sequences are useful in a variety of applications, including diagnostic applications, which will detect naturally occurring nucleic acids, as well as screening applications; e.g., biochips comprising nucleic acid probes or PCR microtiter plates with selected probes to the cancer sequences.
  • a cancer sequence can be initially identified by substantial nucleic acid and/or amino acid sequence homology to the cancer sequences outlined herein. Such homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, e.g., using homology programs or hybridization conditions.
  • the cancer screen typically includes comparing genes identified in different tissues, e.g., normal and cancerous tissues, cancer and non-malignant conditions, non-malignant conditions and normal tissues, or tumor tissue samples from patients who have metastatic disease vs. non metastatic tissue.
  • Other suitable tissue comparisons include comparing cancer samples with metastatic cancer samples from other cancers, such as lung, stomach, gastrointestinal cancers, etc.
  • Samples of different stages of cancer e.g., survivor tissue, drug resistant states, and tissue undergoing metastasis, are applied to biochips comprising nucleic acid probes. The samples are first microdissected, if applicable, and treated for preparation of mRNA.
  • Suitable biochips are commercially available, e.g., from Affymetrix, Santa Clara, CA. Gene expression profiles as described herein are generated and the data analyzed. In one embodiment, the genes showing changes in expression as between normal and disease states are compared to genes expressed in other normal tissues, including, and not limited to lung, heart, brain, liver, stomach, kidney, muscle, colon, small intestine, large intestine, spleen, bone, and/or placenta.
  • those genes identified during the cancer screen that are expressed in a significant amount in other tissues are removed from the profile, although in some embodiments, this is not necessary (e.g., where organs may be dispensible, e.g., female or male specific). That is, when screening for drugs, it is usually preferable that the target expression be disease specific, to minimize possible side effects on other organs were there expression.
  • cancer sequences are those that are up-regulated in cancer; that is, the expression of these genes is higher in the cancer tissue as compared to non-cancer or non-malignant tissue.
  • Up-regulation as used herein often means at least about a two-fold change, preferably at least about a three fold change, with at least about five-fold or higher being prefened.
  • Another embodiment is directed to sequences up-regulated in non-malignant conditions relative to normal. Uniformity among relevant samples is also prefened. Unigene cluster identification numbers and accession numbers herein are for the
  • GenBank sequence database and the sequences of the accession numbers are hereby expressly incorporated by reference.
  • GenBank is available, see, e.g., Benson, et al. (1998) Nuc. Acids Res. 26:1-7; and http://www.ncbi.nlm.nih.gov/.
  • Sequences are also available in other databases, e.g., European Molecular Biology Laboratory (EMBL) and DNA Database of Japan (DDBJ).
  • EMBL European Molecular Biology Laboratory
  • DDBJ DNA Database of Japan
  • the sequences may be derived from assembly of available sequences or be predicted from genomic DNA using exon prediction algorithms, such as FGENESH. See Salamov and Solovyev (2000) Genome Res. 10:516-522.
  • sequences have been derived from cloning and sequencing of isolated nucleic acids.
  • cancer sequences are those that are down-regulated in the cancer; that is, the expression of these genes is lower in cancer tissue as compared to non- cancerous tissue.
  • Down-regulation as used herein often means at least about a two-fold change, preferably at least about a three fold change, with at least about five-fold or higher being prefened.
  • the ability to identify genes that are over or under expressed in cancer can additionally provide high-resolution, high-sensitivity datasets which can be used in the areas of diagnostics, therapeutics, drug development, pharmacogenetics, protein structure, biosensor development, and other related areas.
  • the expression profiles can be used in diagnostic or prognostic evaluation of patients with cancer or related diseases. See Tables 1 and 3.
  • subcellular toxicological information can be generated to better direct drug structure and activity conelation (see Anderson (June 11-12, 1998) Pharmaceutical Proteomics: Targets, Mechanism, and Function, paper presented at the IBC Proteomics conference, Coronado, CA).
  • Subcellular toxicological information can also be utilized in a biological sensor device to predict the likely toxicological effect of chemical exposures and likely tolerable exposure thresholds (see U.S. Patent No. 5,811,231). Similar advantages accrue from datasets relevant to other biomolecules and bioactive agents (e.g., nucleic acids, saccharides, lipids, drugs, and the like).
  • bioactive agents e.g., nucleic acids, saccharides, lipids, drugs, and the like.
  • the present invention provides a database that includes at least one set of assay data.
  • the data contained in the database is acquired, e.g., using anay analysis either singly or in a library format.
  • the database can be in a form in which data can be maintained and transmitted, but is preferably an electronic database.
  • the electronic database of the invention can be maintained on any electronic device allowing for the storage of and access to the database, such as a personal computer, but is preferably distributed on a wide area network, such as the World Wide Web.
  • compositions and methods for identifying and/or quantitating the relative and/or absolute abundance of a variety of molecular and macromolecular species from a biological sample representing cancer e.g., the identification of cancer-associated sequences described herein, provide an abundance of information which can be conelated with pathological conditions, predisposition to disease, drug testing, therapeutic monitoring, gene-disease causal linkages, identification of conelates of immunity and physiological status, among others.
  • the data generated from the assays of the invention is suited for manual review and analysis, in a prefened embodiment, data processing using high-speed computers is utilized.
  • U.S. Patents 6,023,659 and 5,966,712 disclose a relational database system for storing biomolecular sequence information in a manner that allows sequences to be catalogued and searched according to one or more protein function hierarchies.
  • U.S. Patent 5,953,727 discloses a relational database having sequence records containing information in a format that allows a collection of partial-length DNA sequences to be catalogued and searched according to association with one or more sequencing projects for obtaining full-length sequences from the collection of partial length sequences.
  • Patent 5,706,498 discloses a gene database retrieval system for making a retrieval of a gene sequence similar to a sequence data item in a gene database based on the degree of similarity between a key sequence and a target sequence.
  • U.S. Patent 5,538,897 discloses a method using mass spectroscopy fragmentation patterns of peptides to identify amino acid sequences in computer databases by comparison of predicted mass spectra with experimentally-derived mass spectra using a closeness-of-fit measure.
  • U.S. Patent 5,926,818 discloses a multi-dimensional database comprising a functionality for multidimensional data analysis described as on-line analytical processing (OLAP), which entails the consolidation of projected and actual data according to more than one consolidation path or dimension.
  • OLAP on-line analytical processing
  • Patent 5,295,261 reports a hybrid database structure in which the fields of each database record are divided into two classes, navigational and informational data, with navigational fields stored in a hierarchical topological map which can be viewed as a tree structure or as the merger of two or more such tree structures. See also Baxevanis, et al. (2001) Bioinformatics: A Practical Guuide to the Analysis of Genes and Proteins Wiley; Mount (2001) Bioinformatics: Sequence and Genome Analysis CSH Press, NY; Durbin, et al. (eds. 1999)
  • the present invention provides a computer database comprising a computer and software for storing in computer-retrievable form assay data records cross-tabulated, e.g., with data specifying the source of the target-containing sample from which each sequence specificity record was obtained.
  • At least one of the sources of target-containing sample is from a control tissue sample known to be free of pathological disorders.
  • at least one of the sources is a known pathological tissue specimen, e.g., a neoplastic lesion or another tissue specimen to be analyzed for cancer.
  • the assay records cross-tabulate one or more of the following parameters for each target species in a sample: (1) a unique identification code, which can include, e.g., a target molecular structure and/or characteristic separation coordinate (e.g., electrophoretic coordinates); (2) sample source; and (3) absolute and/or relative quantity of the target species present in the sample.
  • the invention also provides for the storage and retrieval of a collection of target data in a computer data storage apparatus, which can include magnetic disks, optical disks, magneto- optical disks, DRAM, SRAM, SGRAM, SDRAM, RDRAM, DDR RAM, magnetic bubble memory devices, and other data storage devices, including CPU registers and on-CPU data storage anays.
  • a computer data storage apparatus can include magnetic disks, optical disks, magneto- optical disks, DRAM, SRAM, SGRAM, SDRAM, RDRAM, DDR RAM, magnetic bubble memory devices, and other data storage devices, including CPU registers and on-CPU data storage anays.
  • the target data records are stored as a bit pattern in an anay of magnetic domains on a magnetizable medium or as an anay of charge states or transistor gate states, such as an array of cells in a DRAM device (e.g., each cell comprised of a transistor and a charge storage area, which may be on the transistor).
  • the invention provides such storage devices, and computer systems built therewith, comprising a bit pattern encoding a protein expression fingerprint record comprising unique identifiers for at least 10 target data records cross-tabulated with target source.
  • the invention preferably provides a method for identifying related peptide or nucleic acid sequences, comprising performing a computerized comparison between a peptide or nucleic acid sequence assay record stored in or retrieved from a computer storage device or database and at least one other sequence.
  • the comparison can include a sequence analysis or comparison algorithm or computer program embodiment thereof (e.g., FASTA, TFASTA, GAP, BESTFIT) and/or the comparison may be of the relative amount of a peptide or nucleic acid sequence in a pool of sequences determined from a polypeptide or nucleic acid sample of a specimen.
  • a sequence analysis or comparison algorithm or computer program embodiment thereof e.g., FASTA, TFASTA, GAP, BESTFIT
  • the comparison may be of the relative amount of a peptide or nucleic acid sequence in a pool of sequences determined from a polypeptide or nucleic acid sample of a specimen.
  • the invention also preferably provides a magnetic disk, such as an IBM-compatible (DOS, Windows, Windows95/98/2000, Windows NT, OS/2) or other format (e.g., Linux, SunOS, Solaris, AK, SCO Unix, VMS, MV, Macintosh, etc.) floppy diskette or hard (fixed, Winchester) disk drive, comprising a bit pattern encoding data from an assay of the invention in a file format suitable for retrieval and processing in a computerized sequence analysis, comparison, or relative quantitation method.
  • a magnetic disk such as an IBM-compatible (DOS, Windows, Windows95/98/2000, Windows NT, OS/2) or other format (e.g., Linux, SunOS, Solaris, AK, SCO Unix, VMS, MV, Macintosh, etc.) floppy diskette or hard (fixed, Winchester) disk drive, comprising a bit pattern encoding data from an assay of the invention in a file format suitable for retrieval and processing
  • the invention also provides a network, comprising a plurality of computing devices linked via a data link, such as an Ethernet cable (coax or lOBaseT), telephone line, ISDN line, wireless network, optical fiber, or other suitable signal transmission medium, whereby at least one network device (e.g., computer, disk anay, etc.) comprises a pattern of magnetic domains (e.g., magnetic disk) and/or charge domains (e.g., an anay of DRAM cells) composing a bit pattern encoding data acquired from an assay of the invention.
  • a network device e.g., computer, disk anay, etc.
  • a pattern of magnetic domains e.g., magnetic disk
  • charge domains e.g., an anay of DRAM cells
  • the invention also provides a method for transmitting assay data that includes generating an electronic signal on an electronic communications device, such as a modem, ISDN terminal adapter, DSL, cable modem, ATM switch, or the like, wherein the signal includes (in native or encrypted format) a bit pattern encoding data from an assay or a database comprising a plurality of assay results obtained by the method of the invention.
  • an electronic communications device such as a modem, ISDN terminal adapter, DSL, cable modem, ATM switch, or the like
  • the signal includes (in native or encrypted format) a bit pattern encoding data from an assay or a database comprising a plurality of assay results obtained by the method of the invention.
  • the invention provides a computer system for comparing a query target to a database containing an anay of data structures, such as an assay result obtained by the method of the invention, and ranking database targets based on the degree of identity and gap weight to the target data.
  • a central processor is preferably initialized to load and execute the computer program for alignment and/or comparison of the assay results.
  • Data for a query target is entered into the central processor via an I/O device.
  • Execution of the computer program results in the central processor retrieving the assay data from the data file, which comprises a binary description of an assay result.
  • the target data or record and the computer program can be fransfened to secondary memory, which is typically random access memory (e.g., DRAM, SRAM, SGRAM, or SDRAM).
  • Targets are ranked according to the degree of conespondence between a selected assay characteristic (e.g., binding to a selected affinity moiety) and the same characteristic of the query target and results are output via an I/O device.
  • a central processor can be a conventional computer (e.g., Intel Pentium, PowerPC, Alpha, PA-8000, SPARC, MIPS 4400, MIPS 10000, VAX, etc.);
  • a program can be a commercial or public domain molecular biology software package (e.g., UWGCG Sequence Analysis Software, Darwin);
  • a data file can be an optical or magnetic disk, a data server, a memory device (e.g., DRAM, SRAM, SGRAM, SDRAM, EPROM, bubble memory, flash memory, etc.);
  • an I/O device can be a terminal comprising a video display and a keyboard, a modem, an ISDN terminal adapter, an Ethernet port, a punched card reader, a magnetic strip reader, or other suitable I/O device.
  • the invention also preferably provides the use of a computer system, such as that described above, which comprises: (1) a computer; (2) a stored bit pattern encoding a collection of peptide sequence specificity records obtained by the methods of the invention, which may be stored in the computer; (3) a comparison target, such as a query target; and (4) a program for alignment and comparison, typically with rank-ordering of comparison results on the basis of computed similarity values.
  • a computer system such as that described above, which comprises: (1) a computer; (2) a stored bit pattern encoding a collection of peptide sequence specificity records obtained by the methods of the invention, which may be stored in the computer; (3) a comparison target, such as a query target; and (4) a program for alignment and comparison, typically with rank-ordering of comparison results on the basis of computed similarity values.
  • Cancer proteins of the present invention may be classified as secreted proteins, transmembrane proteins, or intracellular proteins.
  • the cancer protein is an intracellular protein.
  • Intracellular proteins may be found in the cytoplasm and/or in the nucleus. Intracellular proteins are involved in all aspects of cellular function and replication (including, e.g., signaling pathways); abenant expression of such proteins often results in unregulated or disregulated cellular processes (see, e.g., Alberts, et al. (eds. 1994) Molecular Biology of the Cell (3d ed.) Garland).
  • intracellular proteins have enzymatic activity such as protein kinase activity, protein phosphatase activity, protease activity, nucleotide cyclase activity, polymerase activity, and the like.
  • Intracellular proteins also serve as docking proteins that are involved in organizing complexes of proteins, or targeting proteins to various subcellular localizations, and are involved in maintaining the structural integrity of organelles.
  • An increasingly appreciated concept in characterizing proteins is the presence in the proteins of one or more structural motifs for which defined functions have been attributed.
  • highly conserved sequences have been identified in proteins that are involved in protein-protein interaction.
  • Src-homology-2 (SH2) domains bind tyrosine-phosphorylated targets in a sequence dependent manner.
  • PTB domains which are distinct from SH2 domains, also bind tyrosine phosphorylated targets.
  • SH3 domains bind to proline-rich targets.
  • PH domains, tetratricopeptide repeats and WD domains have been shown to mediate protein-protein interactions. Some of these may also be involved in binding to phospholipids or other second messengers.
  • These motifs can be identified on the basis of amino acid sequence; thus, an analysis of the sequence of proteins may provide insight into both the enzymatic potential of the molecule and/or molecules with which the protein may associate.
  • Pfam protein families
  • Pfam protein families
  • the cancer sequences are transmembrane proteins.
  • Transmembrane proteins are molecules that span a phospholipid bilayer of a cell. They may have an intracellular domain, an extracellular domain, or both.
  • the intracellular domains of such proteins may have a number of functions including those already described for intracellular proteins.
  • the intracellular domain may have enzymatic activity and/or may serve as a binding site for additional proteins.
  • the intracellular domain of transmembrane proteins serves both roles.
  • certain receptor tyrosine kinases have both protein kinase activity and SH2 domains.
  • autophosphorylation of tyrosines on the receptor molecule itself creates binding sites for additional SH2 domain containing proteins.
  • Transmembrane proteins may contain from one to many transmembrane domains.
  • receptor tyrosine kinases certain cytokine receptors, receptor guanylyl cyclases and receptor serine/threonine protein kinases contain a single transmembrane domain.
  • various other proteins including channels and adenylyl cyclases contain numerous transmembrane domains.
  • Many important cell surface receptors such as G protein coupled receptors (GPCRs) are classified as "seven transmembrane domain" proteins, as they contain 7 membrane spanning regions. Characteristics of transmembrane domains include approximately 17 consecutive hydrophobic amino acids that may be followed by charged amino acids.
  • transmembrane protein receptors include, but are not limited to the insulin receptor, insulin-like growth factor receptor, human growth hormone receptor, glucose transporters, transferrin receptor, epidermal growth factor receptor, low density lipoprotein receptor, epidermal growth factor receptor, leptin receptor, and interieukin receptors, e.g., IL-1 receptor, IL-2 receptor, etc.
  • extracellular domains of transmembrane proteins are diverse; however, conserved motifs are found repeatedly among various extracellular domains. conserveed structure and/or functions have been ascribed to different extracellular motifs. Many extracellular domains are involved in binding to other molecules. In one aspect, extracellular domains are found on receptors. Factors that bind the receptor domain include circulating ligands, which may be peptides, proteins, or small molecules such as adenosine and the like. For example, growth factors such as EGF, FGF, and PDGF are circulating growth factors that bind to their cognate receptors to initiate a variety of cellular responses. Other factors include cytokines, mitogenic factors, neurotrophic factors, and the like.
  • Extracellular domains also bind to cell-associated molecules. In this respect, they may mediate cell-cell interactions.
  • Cell-associated ligands can be tethered to the cell, e.g., via a glycosylphosphatidylinositol (GPI) anchor, or may themselves be transmembrane proteins.
  • Extracellular domains may also associate with the extracellular matrix and contribute to the maintenance of the cell structure.
  • transmembrane proteins are particularly prefened in the present invention as they are readily accessible targets for immunotherapeutics, as are described herein.
  • transmembrane proteins can be also useful in imaging modalities.
  • Antibodies may be used to label such readily accessible proteins in situ.
  • antibodies can also label intracellular proteins, in which case samples are typically permeablized to provide access to intracellular proteins.
  • some membrane proteins can be processed to release a soluble protein, or to expose a residual fragment. Released soluble proteins may be useful diagnostic markers, processed residual protein fragments may be useful lung markers of disease.
  • transmembrane protein can be made soluble by removing transmembrane sequences, e.g., through recombinant methods.
  • transmembrane proteins that have been made soluble can be made to be secreted through recombinant means by adding an appropriate signal sequence.
  • the cancer proteins are secreted proteins; the secretion of which can be either constitutive or regulated. These proteins may have a signal peptide or signal sequence that targets the molecule to the secretory pathway. Secreted proteins are involved in numerous physiological events; e.g., if circulating, they often serve to transmit signals to various other cell types.
  • the secreted protein may function in an autocrine manner (acting on the cell that secreted the factor), a paracrine manner (acting on cells in close proximity to the cell that secreted the factor), an endocrine manner (acting on cells at a distance, e.g, secretion into the blood stream), or exocrine (secretion, e.g., through a duct or to adjacent epithelial surface as sweat glands, sebaceous glands, pancreatic ducts, lacrimal glands, mammary glands, wax producing glands of the ear, etc.).
  • secreted molecules often find use in modulating or altering numerous aspects of physiology.
  • Cancer proteins that are secreted proteins are particularly prefened in the present invention as they serve as good targets for diagnostic markers, e.g., for blood, plasma, serum, or stool tests. Those which are enzymes may be antibody or small molecule targets. Others may be useful as vaccine targets, e.g., via CTL mechanisms. Use of cancer nucleic acids
  • cancer sequence is initially identified by substantial nucleic acid and/or amino acid sequence homology or linkage to the cancer sequences outlined herein.
  • homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, using either homology programs or hybridization conditions.
  • linked sequences on a mRNA are found on the same molecule.
  • percent identity can be determined using an algorithm such as BLAST.
  • a prefened method utilizes the BLASTN module of WU-BLAST-2 set to the default parameters, with overlap span and overlap fraction set to 1 and 0.125, respectively.
  • Alignment may include the introduction of gaps in the sequences to be aligned.
  • the percentage of homology may be determined based on the number of homologous nucleosides in relation to the total number of nucleosides. Thus, e.g., homology of sequences shorter than those of the sequences identified will be determined using the number of nucleosides in the shorter sequence.
  • the nucleic acid homology is determined through hybridization studies.
  • nucleic acids which hybridize under high stringency to a described nucleic acid, or its complement, or is also found on naturally occurring mRNAs is considered a cancer sequence.
  • less stringent hybridization conditions are used; e.g., moderate or low stringency conditions may be used; see Ausubel, supra, and Tijssen, supra.
  • the cancer nucleic acid sequences of the invention e.g., the sequences in Tables 1-68, can be fragments of larger genes, e.g., they are nucleic acid segments. "Genes" in this context includes coding regions, non-coding regions, and mixtures of coding and non-coding regions.
  • extended sequences, in either direction, of the cancer genes can be obtained, using techniques well known for cloning either longer sequences or the full length sequences; see Ausubel, et al., supra. Much can be done by informatics and many sequences can be clustered to include multiple sequences conesponding to a single gene, e.g., systems such as UniGene (see, http://www.ncbi.nlm.nih.gov/UniGene/).
  • a cancer nucleic acid Once a cancer nucleic acid is identified, it can be cloned and, if necessary, its constituent parts recombined to form the entire cancer nucleic acid coding regions or the entire mRNA sequence.
  • the recombinant cancer nucleic acid Once isolated from its natural source, e.g., contained within a plasmid or other vector or excised therefrom as a linear nucleic acid segment, the recombinant cancer nucleic acid can be further used as a probe to identify and isolate other cancer nucleic acids, e.g., extended coding regions. It can also be used as a "precursor" nucleic acid to make modified or variant cancer nucleic acids and proteins.
  • nucleic acid probes to the cancer nucleic acids are made and attached to biochips to be used in screening and diagnostic methods, as outlined below, or for administration, e.g., for gene therapy, vaccine, RNAi, and/or antisense applications.
  • cancer nucleic acids that include coding regions of cancer proteins can be put into expression vectors for the expression of cancer proteins, again for screening purposes or for administration to a patient.
  • nucleic acid probes to cancer nucleic acids both the nucleic acid sequences outlined in the figures and/or the complements thereof are made.
  • the nucleic acid probes attached to the biochip are designed to be substantially complementary to the cancer nucleic acids, e.g., the target sequence (either the target sequence of the sample or to other probe sequences, e.g., in sandwich assays), such that hybridization of the target sequence and the probes of the present invention occurs.
  • this complementarity need not be perfect; there may be any number of base pair mismatches which will interfere with hybridization between the target sequence and the single stranded nucleic acids of the present invention.
  • the sequence is not a complementary target sequence.
  • substantially complementary herein is meant that the probes are sufficiently complementary to the target sequences to hybridize under normal reaction conditions, particularly high stringency conditions, as outlined herein.
  • a nucleic acid probe is generally single stranded but can be partially single and partially double stranded.
  • the strandedness of the probe is dictated by the structure, composition, and properties of the target sequence.
  • lhe nucleic acid probes range from about 8-100 bases long, with from about 10-80 bases being prefened, and from about 30-50 bases being particularly prefened. That is, generally whole genes are not used. In some embodiments, much longer nucleic acids can be used, up to hundreds of bases.
  • more than one probe per sequence is used, with either overlapping probes or probes to different sections of the target being used. That is, two, three, four or more probes, with three being prefened, are used to build in a redundancy for a particular target.
  • the probes can be overlapping (e.g., have some sequence in common), or separate.
  • PCR primers may be used to amplify signal for higher sensitivity.
  • Nucleic acids can be attached or immobilized to a solid support in a wide variety of ways. By “immobilized” and grammatical equivalents herein is meant the association or binding between the nucleic acid probe and the solid support is sufficient to be stable under the conditions of binding, washing, analysis, and removal as outlined.
  • the binding can typically be covalent or non-covalent.
  • non-covalent binding and grammatical equivalents herein is meant one or more of electrostatic, hydrophilic, and hydrophobic interactions. Included in non- covalent binding is the covalent attachment of a molecule, e.g., streptavidin to the support and the non-covalent binding of the biotinylated probe to the streptavidin.
  • covalent binding and grammatical equivalents herein is meant that the two moieties, the solid support and the probe, are attached by at least one bond, including sigma bonds, pi bonds, and coordination bonds.
  • Covalent bonds can be formed directly between the probe and the solid support or can be formed by a cross linker or by inclusion of a specific reactive group on either the solid support or the probe or both molecules. Immobilization may also involve a combination of covalent and non-covalent interactions.
  • the probes are attached to the biochip in a wide variety of ways.
  • the nucleic acids can either be synthesized first, with subsequent attachment to the biochip, or can be directly synthesized on the biochip.
  • the biochip comprises a suitable solid substrate.
  • substrate or “solid support” or
  • the substrate may contain discrete individual sites appropriate for individual partitioning and identification.
  • the number of possible substrates is very large, and include, but are not limited to, glass and modified or functionalized glass, plastics (including acrylics, polystyrene and copolymers of styrene and other materials, polypropylene, polyethylene, polybutylene, polyurethanes, TeflonJ, etc.), polysaccharides, nylon or nitrocellulose, resins, silica or silica-based materials including silicon and modified silicon, carbon, metals, inorganic glasses, plastics, etc.
  • the substrates allow optical detection and do not appreciably fluoresce. See WO 0055627.
  • the substrate is planar, although other configurations of substrates may be used as well.
  • the probes may be placed on the inside surface of a tube for flow- through sample analysis to minimize sample volume.
  • the substrate may be flexible, such as a flexible foam, including closed cell foams made of particular plastics.
  • the surface of the biochip and the probe may be derivatized with chemical functional groups for subsequent attachment of the two.
  • the biochip is derivatized with a chemical functional group including, but not limited to, amino groups, carboxy groups, oxo groups, and thiol groups, with amino groups being particularly prefened.
  • the probes can be attached using functional groups on the probes.
  • nucleic acids containing amino groups can be attached to surfaces comprising amino groups, e.g., using linkers; e.g., homo-or hetero-bifunctional linkers as are well known (see 1994 Pierce Chemical Company catalog, technical section on cross-linkers, pages 155-
  • additional linkers such as alkyl groups (including substituted and heteroalkyl groups) may be used.
  • oligonucleotides are synthesized, and then attached to the surface of the solid support. Either the 5' or 3' terminus may be attached to the solid support, or attachment may be via linkage to an internal nucleoside.
  • the immobilization to the solid support may be very strong, yet non-covalent.
  • biotinylated oligonucleotides can be made, which bind to surfaces covalently coated with streptavidin, resulting in attachment.
  • the oligonucleotides may be synthesized on the surface.
  • photoactivation techniques utilizing photopolymerization compounds and techniques are used.
  • the nucleic acids can be synthesized in situ, using known photolithographic techniques, such as those described in WO 95/25116; WO 95/35505; U.S. Patent Nos. 5,700,637 and 5,445,934; and references cited within, all of which are expressly incorporated by reference; these methods of attachment form the basis of the Affymetrix GeneChipTM technology.
  • amplification-based assays are performed to measure the expression level of cancer-associated sequences. These assays are typically performed in conjunction with reverse transcription.
  • a cancer-associated nucleic acid sequence acts as a template in an amplification reaction (e.g., Polymerase Chain Reaction, or PCR).
  • an amplification reaction e.g., Polymerase Chain Reaction, or PCR.
  • the amount of amplification product will be proportional to the amount of template in the original sample. Comparison to appropriate controls provides a measure of the amount of cancer-associated RNA.
  • Methods of quantitative amplification are well known. Detailed protocols for quantitative PCR are provided, e.g., in Innis, et al. (1990) PCR Protocols. A Guide to Methods and Applications Academic Press.
  • a TaqMan based assay is used to measure expression.
  • TaqMan based assays use a fluorogenic oligonucleotide probe that contains a 5' fluorescent dye and a 3' quenching agent. The probe hybridizes to a PCR product, but cannot itself be extended due to a blocking agent at the 3' end.
  • the 5' nuclease activity of the polymerase e.g., AmpliTaq
  • This cleavage separates the 5' fluorescent dye and the 3' quenching agent, thereby resulting in an increase in fluorescence as a function of amplification (see, e.g., literature provided by Perkin-Elmer, e.g., www2.perkin-elmer.com).
  • ligase chain reaction (LCR) (see Wu and Wallace (1989) Genomics 4:560-569, Landegren, et al. (1988) Science 241:1077-1080, and Ba ⁇ inger, et al. (1990) Gene 89:117-122), transcription amplification (Kwoh, et al. (1989) Proc. Natl. Acad. Sci. USA 86:1173-1177), self-sustained sequence replication (Guatelli, et al. (1990) Proc. Nat. Acad. Sci. USA 87:1874-1878), dot PCR, linker adapter PCR, etc. Expression of cancer proteins from nucleic acids
  • cancer nucleic acids e.g., encoding cancer proteins
  • expression vectors and recombinant DNA technology are -well known (see, e.g., Ausubel, supra, and Fernandez and Hoeffler (eds. 1999) Gene Expression Systems Academic Press) to express proteins.
  • the expression vectors may be either self- replicating extrachromosomal vectors or vectors which integrate into a host genome.
  • these expression vectors include transcriptional and translational regulatory nucleic acid operably linked to the nucleic acid encoding the cancer protein.
  • control sequences refers to DNA sequences used for the expression of an operably linked coding sequence in a particular host organism. Control sequences that are suitable for prokaryotes, e.g., include a promoter, optionally an operator sequence, and a ribosome binding site. Eukaryotic cells are known to utilize promoters, polyadenylation signals, and enhancers. Nucleic acid is "operably linked” when it is placed into a functional relationship with another nucleic acid sequence.
  • DNA for a presequence or secretory leader is operably linked to DNA for a polypeptide if it is expressed as a preprotein that participates in the secretion of the polypeptide; a promoter or enhancer is operably linked to a coding sequence if it affects the transcription of the sequence; or a ribosome binding site is operably linked to a coding sequence if it is positioned so as to facilitate translation.
  • "operably linked" means that the DNA sequences being linked are contiguous, and, in the case of a secretory leader, contiguous and in reading phase. However, enhancers do not have to be contiguous. Linking is typically accomplished by ligation at convenient restriction sites.
  • Transcriptional and translational regulatory nucleic acid will generally be appropriate to the host cell used to express the cancer protein. Numerous types of appropriate expression vectors and suitable regulatory sequences are known for a variety of host cells.
  • transcriptional and translational regulatory sequences may include, but are not limited to, promoter sequences, ribosomal binding sites, transcriptional start and stop sequences, translational start and stop sequences, and enhancer or activator sequences.
  • the regulatory sequences include a promoter and transcriptional start and stop sequences.
  • Promoter sequences may be either constitutive or inducible promoters.
  • the promoters may be either naturally occurring promoters or hybrid promoters. Hybrid promoters, which combine elements of more than one promoter, are also known, and are useful in the present invention.
  • An expression vector may comprise additional elements.
  • the expression vector may have two replication systems, thus allowing it to be maintained in two organisms, e.g., in mammalian or insect cells for expression and in a prokaryotic host for cloning and amplification.
  • the expression vector often contains at least one sequence homologous to the host cell genome, and preferably two homologous sequences which flank the expression construct.
  • the integrating vector may be directed to a specific locus in the host cell by selecting the appropriate homologous sequence for inclusion in the vector. Constructs for integrating vectors are available. See, e.g., Fernandez and Hoeffler, supra; and Kitamura, et al. (1995) Proc. Nat'l Acad. Sci. USA 92:9146- 9150.
  • the expression vector contains a selectable marker gene to allow the selection of transformed host cells. Selection genes are well known and will vary with the host cell used.
  • the cancer proteins of the present invention are usually produced by culturing a host cell transformed with an expression vector containing nucleic acid encoding a cancer protein, under the appropriate conditions to induce or cause expression of the cancer protein.
  • Conditions appropriate for cancer protein expression will vary with the choice of the expression vector and the host cell, and will be easily ascertained through routine experimentation or optimization.
  • the use of constitutive promoters in the expression vector will require optimizing the growth and proliferation of the host cell, while the use of an inducible promoter requires the appropriate growth conditions for induction.
  • the timing of the harvest is important.
  • the baculoviral systems used in insect cell expression are lytic viruses, and thus harvest time selection can be crucial for product yield.
  • Appropriate host cells include yeast, bacteria, archaebacteria, fungi, and insect and animal cells, including mammalian cells. Of particular interest are Saccharomyces cerevisiae and other yeasts, E. coli, Bacillus subtilis, Sf9 cells, C129 cells, 293 cells, Neurospora, BHK, CHO, COS, HeLa cells, HUVEC (human umbilical vein endothelial cells), THP1 cells (a macrophage cell line), and various other human cells and cell lines.
  • the cancer proteins are expressed in mammalian cells.
  • Mammalian expression systems may be used, and include retroviral and adenoviral systems.
  • One expression vector system is a retroviral vector system such as is generally described in PCT/US97/01019 and PCT/US97/01048.
  • mammalian promoters are the promoters from mammalian viral genes, since the viral genes are often highly expressed and have a broad host range. Examples include the SV40 early promoter, mouse mammary tumor virus LTR promoter, adenovirus major late promoter, herpes simplex virus promoter, and the CMV promoter (see, e.g., Fernandez and Hoeffler, supra).
  • transcription termination and polyadenylation sequences recognized by mammalian cells are regulatory regions located 3' to the translation stop codon and thus, together with the promoter elements, flank the coding sequence.
  • transcription terminator and polyadenlyation signals include those derived from SV40.
  • Methods of introducing exogenous nucleic acid into mammalian hosts, as well as other hosts, are available, and will vary with the host cell used. Techniques include dextran-mediated transfection, calcium phosphate precipitation, polybrene mediated transfection, protoplast fusion, electroporation, viral infection, encapsulation of the polynucleotide(s) in liposomes, and direct microinjection of the DNA into nuclei. In a prefened embodiment, cancer proteins are expressed in bacterial systems. Promoters from bacteriophage may also be used. In addition, synthetic promoters and hybrid promoters are also useful; e.g., the tac promoter is a hybrid of the trp and lac promoter sequences.
  • a bacterial promoter can include naturally occurring promoters of non- bacterial origin that have the ability to bind bacterial RNA polymerase and initiate transcription. In addition to a functioning promoter sequence, an efficient ribosome binding site is desirable.
  • the expression vector may also include a signal peptide sequence that provides for secretion of the cancer protein in bacteria. The protein is either secreted into the growth media (gram- positive bacteria) or into the periplasmic space, located between the inner and outer membrane of the cell (gram-negative bacteria).
  • the bacterial expression vector may also include a selectable marker gene to allow for the selection of bacterial strains that have been transformed.
  • Suitable selection genes include genes which render the bacteria resistant to drugs such as ampicillin, chloramphenicol, erytbromycin, kanamycin, neomycin, and tetracycline. Selectable markers also include biosynthetic genes, such as those in the histidine, tryptophan, and leucine biosynthetic pathways. These components are assembled into expression vectors.
  • Expression vectors for bacteria are well known, and include vectors for Bacillus subtilis, E. coli, Streptococcus cremoris, and Streptococcus lividans, among others (e.g., Fernandez and Hoeffler, supra).
  • the bacterial expression vectors are transformed into bacterial host cells using techniques such as calcium chloride treatment, electroporation, and others.
  • cancer proteins are produced in insect cells using, e.g., expression vectors for the transformation of insect cells, and in particular, baculo virus-based expression vectors.
  • a cancer protein is produced in yeast cells.
  • Yeast expression systems are well known, and include expression vectors for Saccharomyces cerevisiae, Candida albicans and C. maltosa, Hansenula polymorpha, Kluyveromyces fragilis and K. lactis, Pichia guillerimondii and P. pastoris, Schizosaccharomyces pombe, and Yanowia lipolytica.
  • the cancer protein may also be made as a fusion protein, using available techniques.
  • the cancer protein may be fused to a carrier protein to form an immunogen.
  • the cancer protein may be made as a fusion protein to increase expression, or for other reasons.
  • the cancer protein is a cancer peptide
  • the nucleic acid encoding the peptide may be linked to other nucleic acid for expression purposes. Fusion with detection epitope tags can be made, e.g., with FLAG, His6, myc, HA, etc.
  • the cancer protein is purified or isolated after expression.
  • Cancer proteins may be isolated or purified in a variety of ways depending on what other components are present in the sample and the requirements for purified product, e.g., natural conformation or denatured.
  • Standard purification methods include ammonium sulfate precipitations, electrophoretic, molecular, immunological, and chromatographic techniques, including ion exchange, hydrophobic, affinity, and reverse-phase HPLC chromatography, and chromatofocusing.
  • the cancer protein may be purified using a standard anti- cancer protein antibody column. Ultrafiltration and diafiltration techniques, in conjunction with protein concentration, are also useful.
  • cancer proteins and nucleic acids are useful in a number of applications. They may be used as immunoselection reagents, as vaccine reagents, as screening agents, therapeutic entities, for production of antibodies, as transcription or translation inhibitors, etc. Variants of cancer proteins
  • cancer proteins are amino acid variants of the naturally occurring sequences, as determined herein.
  • the variants are preferably greater than about 75% homologous to the wild-type sequence, more preferably greater than about 80%, even more preferably greater than about 85%, and most preferably greater than 90%.
  • the homology will be as high as about 93-95% or 98%.
  • nucleic acids homology in this context means sequence similarity or identity, with identity being prefened. This homology will be determined using standard techniques, as are outlined above for nucleic acid homologies. Cancer proteins of the present invention may be shorter or longer than the wild type amino acid sequences.
  • cancer proteins included within the definition of cancer proteins are portions or fragments of the wild type sequences herein.
  • the cancer nucleic acids of the invention may be used to obtain additional coding regions, and thus additional protein sequence.
  • the cancer proteins are derivative or variant cancer proteins as compared to the wild-type sequence. That is, as outlined more fully below, the derivative cancer peptide will often contain at least one amino acid substitution, deletion, or insertion, with amino acid substitutions being particularly prefened. The amino acid substitution, insertion, or deletion may occur at many residue positions within the cancer peptide.
  • amino acid sequence variants typically fall into one or more of three classes: substitutional, insertional, or deletional variants. These variants ordinarily are prepared by site specific mutagenesis of nucleotides in the DNA encoding the cancer protein, using cassette or PCR mutagenesis or other techniques, to produce DNA encoding the variant, and thereafter expressing the DNA in recombinant cell culture as outlined above. However, variant cancer protein fragments having up to about 100-150 residues may be prepared by in vitro synthesis using established techniques. Amino acid sequence variants are characterized by the predetermined nature of the variation, a feature that sets them apart from naturally occurring allelic or interspecies variation of the cancer protein amino acid sequence.
  • the variants typically exhibit a similar qualitative biological activity as a naturally occurring analogue, although variants can also be selected which have modified characteristics. While the site or region for introducing an amino acid sequence variation is often predetermined, the mutation per se need not be predetermined. For example, in order to optimize the performance of a mutation at a given site, random mutagenesis may be conducted at the target codon or region and the expressed cancer variants screened for the optimal combination of desired activity. Techniques for making substitution mutations at predetermined sites in DNA having a known sequence are well known, e.g., Ml 3 primer mutagenesis and PCR mutagenesis. Screening of mutants is often done using assays of cancer protein activities.
  • Amino acid substitutions are typically of single residues; insertions usually will be on the order of from about 1-20 amino acids, although considerably larger insertions may be tolerated. Deletions generally range from about 1-20 residues, although in some cases deletions may be much larger.
  • substitutions deletions, insertions, or combination thereof may be used to arrive at a final derivative. Generally these changes are done on a few amino acids to minimize the alteration of the molecule. However, larger changes may be tolerated in certain circumstances. When small alterations in the characteristics of the cancer protein are desired, substitutions are generally made in accordance with the amino acid substitution relationships described.
  • variants typically exhibit essentially the same qualitative biological activity and will elicit the same immune response as a naturally-occurring analog, although variants also are selected to modify the characteristics of cancer proteins as needed.
  • the variant may be designed such that a biological activity of the cancer protein is altered. For example, glycosylation sites may be added, altered, or removed.
  • substitutions that are less conservative than those described above.
  • substitutions may be made which more significantly affect: the structure of the polypeptide backbone in the area of the alteration, for example the alpha-helical or beta-sheet structure; the charge or hydrophobicity of the molecule at the target site; or the bulk of the side chain.
  • substitutions which generally are expected to produce the greatest changes in the polypeptide's properties are those in which (a) a hydrophilic residue, e.g., serine or threone is substituted for (or by) a hydrophobic residue, e.g., leucine, isoleucine, phenylalanine, valine, or alanine; (b) a cysteine or proline is substituted for (or by) another residue; (c) a residue having an electropositive side chain, e.g., lysine, arginine, or histidine, is substituted for (or by) an electronegative residue, e.g., glutamic or aspartic acid; (d) a residue having a bulky side chain, e.g., phenylalanine, is substituted for (or by) one not having a side chain, e.g., glycine; or (e) a proline residue is inco ⁇ orated or substituted, which changes the degree
  • Variants typically exhibit a similar qualitative biological activity and will elicit the same immune response as the naturally-occurring analog, although variants also are selected to modify the characteristics of the skin cancer proteins as needed.
  • the variant may be designed such that the biological activity of the cancer protein is altered. For example, glycosylation sites may be altered or removed.
  • Covalent modifications of cancer polypeptides are included within the scope of this invention.
  • One type of covalent modification includes reacting targeted amino acid residues of a cancer polypeptide with an organic derivatizing agent that is capable of reacting with selected side chains or the N-or C-terminal residues of a cancer polypeptide.
  • Derivatization with bifunctional agents is useful, for instance, for crosslinking cancer polypeptides to a water- insoluble support matrix or surface for use in a method for purifying anti-cancer polypeptide antibodies or screening assays, as is more fully described below.
  • crosslinking agents include, e.g., l,l-bis(diazoacetyl)-2-phenylethane, glutaraldehyde, N- hydroxysuccinimide esters, e.g., esters with 4-azidosalicylic acid, homobifunctional imidoesters, including disuccinimidyl esters such as 3,3'-dithiobis(succinimidylpropionate), bifunctional maleimides such as bis-N-maleimido-l,8-octane and agents such as methyl-3-((p- azidophenyl)dithio)propioimidate.
  • l,l-bis(diazoacetyl)-2-phenylethane glutaraldehyde
  • N- hydroxysuccinimide esters e.g., esters with 4-azidosalicylic acid
  • homobifunctional imidoesters including disuccinimidyl esters such
  • Another type of covalent modification of the cancer polypeptide included within the scope of this invention comprises altering the native glycosylation pattern of the polypeptide.
  • "Altering the native glycosylation pattern” is intended for purposes herein to mean deleting one or more carbohydrate moieties found in native sequence cancer polypeptide, and/or adding one or more glycosylation sites that are not present in the native sequence cancer polypeptide.
  • Glycosylation patterns can be altered in many ways. Different cell types to express cancer- associated sequences can result in different glycosylation patterns.
  • Addition of glycosylation sites to cancer polypeptides may also be accomplished by altering the amino acid sequence thereof.
  • the alteration may be made, e.g., by the addition of, or substitution by, one or more serine or threonine residues to the native sequence cancer polypeptide (for O-linked glycosylation sites).
  • the cancer amino acid sequence may optionally be altered through changes at the DNA level, particularly by mutating the DNA encoding the cancer polypeptide at preselected bases such that codons are generated that will translate into the desired amino acids.
  • Another means of increasing the number of carbohydrate moieties on the cancer polypeptide is by chemical or enzymatic coupling of glycosides to the polypeptide. See, e.g., WO 87/05330; pp. 259-306 in Aplin and Wriston (1981) CRC Crit. Rev. Biochem. Removal of carbohydrate moieties present on the cancer polypeptide may be accomplished chemically or enzymatically or by mutational substitution of codons encoding for amino acid residues that serve as targets for glycosylation. Chemical deglycosylation techniques are applicable. See, e.g., Sojar and Bahl (1987) Arch. Biochem. Biophys. 259:52-57 and Edge, et al. (1981) Anal.
  • Enzymatic cleavage of carbohydrate moieties on polypeptides can be achieved by the use of a variety of endo-and exo-glycosidases. See, e.g., Thotakura, et al. (1987) Meth. Enzymol. 138:350-359.
  • Another type of covalent modification of cancer comprises linking the cancer polypeptide to one of a variety of nonproteinaceous polymers, e.g., polyethylene glycol, polypropylene glycol, or polyoxyalkylenes, in the manner set forth in U.S. Patent Nos. 4,640,835; 4,496,689; 4,301,144; 4,670,417; 4,791,192, or 4,179,337.
  • Cancer polypeptides of the present invention may also be modified in a way to form chimeric molecules comprising a cancer polypeptide fused to another heterologous polypeptide or amino acid sequence.
  • such a chimeric molecule comprises a fusion of a cancer polypeptide with a tag polypeptide which provides an epitope to which an anti-tag antibody can selectively bind.
  • the epitope tag is generally placed at the amino-or carboxyl- terminus of the cancer polypeptide. The presence of such epitope-tagged forms of a cancer polypeptide can be detected using an antibody against the tag polypeptide. Also, provision of the epitope tag enables the cancer polypeptide to be readily purified by affinity purification using an anti-tag antibody or another type of affinity matrix that binds to the epitope tag.
  • the chimeric molecule may comprise a fusion of a cancer polypeptide with an immunoglobulin or a particular region of an immunoglobulin.
  • a fusion coulcbbe to the Fc region of an IgG molecule.
  • tag polypeptides and their respective antibodies are available. Examples include poly-histidine (poly-his) or poly-histidine-glycine (poly-his-gly) tags; HIS6 and metal chelation tags, the flu HA tag polypeptide and its antibody 12CA5 (Field, et al. (1988) Mol. Cell. Biol. 8:2159-2165); the c-myc tag and the 8F9, 3C7, 6E10, G4, B7, and 9E10 antibodies thereto (Evan, et al. (1985) Molecular and Cellular Biology 5:3610-3616); and the He ⁇ es Simplex virus glycoprotein D (gD) tag and its antibody (Paborsky, et al.
  • tag polypeptides include the Flag-peptide (Hopp, et al. (1988) BioTechnology 6:1204-1210); the KT3 epitope peptide (Martin, et al. (1992) Science 255:192-194); tubulin epitope peptide (Skinner, et al. (1991) J. Biol. Chem. 266:15163-15166); and the T7 gene 10 protein peptide tag (Lutz-Freyermuth, et al. (1990) Proc. Natl. Acad. Sci. USA 87:6393-6397).
  • probe or degenerate polymerase chain reaction (PCR) primer sequences may be used to find other related cancer proteins from humans or other organisms.
  • Particularly useful probe and/or PCR primer sequences include the unique areas of the cancer nucleic acid sequence.
  • Prefened PCR primers are from about 15-35 nucleotides in length, with from about 20-30 being prefened, and may contain inosine as needed. The conditions for PCR reaction have been well described (e.g., Innis, PCR Protocols, supra).
  • cancer proteins can be made that are longer than those encoded by the nucleic acids of the Tables, e.g., by the elucidation of extended sequences, the addition of epitope or purification tags, the addition of other fusion sequences, etc.
  • Cancer proteins may also be identified as being encoded by cancer nucleic acids. Thus, cancer proteins are encoded by nucleic acids that will hybridize to the sequences of the sequence listings, or their complements, as outlined herein. Antibodies to cancer proteins
  • the cancer protein when the cancer protein is to be used to generate antibodies, e.g., for immunotherapy or immunodiagnosis, the cancer protein should share at least one epitope or determinant with the full length protein.
  • epitope or “determinant” herein is typically meant a portion of a protein which will generate and/or bind an antibody or T-cell receptor in the context of MHC.
  • the epitope is unique; that is, antibodies generated to a unique epitope show little or no cross-reactivity.
  • the epitope is selected from a protein sequence set out in the tables. Methods of preparing polyclonal antibodies exist (e.g., Coligan, supra; and Harlow and
  • Polyclonal antibodies can be raised in a mammal, e.g., by one or more injections of an immunizing agent and, if desired, an adjuvant.
  • the immunizing agent and/or adjuvant will be injected in the mammal by multiple subcutaneous or intraperitoneal injections.
  • the immunizing agent may include a protein encoded by a nucleic acid of Tables 1-68 or fragment thereof or a fusion protein thereof. It may be useful to conjugate the immunizing agent to a protein known to be immunogenic in the mammal being immunized.
  • immunogenic proteins include but are not limited to keyhole limpet hemocyanin, serum albumin, bovine thyroglobulin, and soybean trypsin inhibitor.
  • adjuvants which may be employed include Freund's complete adjuvant and MPL-TDM adjuvant (monophosphoryl Lipid A, synthetic trehalose dicorynomycolate).
  • MPL-TDM adjuvant monophosphoryl Lipid A, synthetic trehalose dicorynomycolate.
  • the antibodies may, alternatively, be monoclonal antibodies. Monoclonal antibodies may be prepared using hybridoma methods, such as those described by Kohler and Milstein (1975) Nature 256:495.
  • a mouse, hamster, or other appropriate host animal is typically immumzed with an immunizing agent to elicit lymphocytes that produce or are capable of producing antibodies that will specifically bind to the immunizing agent.
  • the lymphocytes may be immunized in vitro.
  • the immunizing agent will typically include a polypeptide encoded by a nucleic acid of the tables or fragment thereof, or a fusion protein thereof.
  • PBLs peripheral blood lymphocytes
  • spleen cells or lymph node cells are used if non-human mammalian sources are desired.
  • the lymphocytes are then fused with an immortalized cell line using a suitable fusing agent, such as polyethylene glycol, to form a hybridoma cell (e.g., pp. 59-103 in Goding (1986) Monoclonal Antibodies: Principles and Practice Academic Press).
  • Immortalized cell lines are usually transformed mammalian cells, particularly myeloma cells of rodent, bovine, or human origin. Usually, rat or mouse myeloma cell lines are employed.
  • the hybridoma cells may be cultured in a suitable culture medium that preferably contains one or more substances that inhibit the growth or survival of the unfused, immortalized cells.
  • the culture medium for the hybridomas typically will include hypoxanthine, aminopterin, and thymidine ("HAT medium"), which substances prevent the growth of HGPRT-deficient cells.
  • HGPRT medium hypoxanthine, aminopterin, and thymidine
  • the antibodies are bispecific antibodies. Bispecific antibodies are monoclonal, preferably human or humanized, antibodies that have binding specificities for at least two different antigens or that have binding specificities for two epitopes on the same antigen.
  • one of the binding specificities is for a protein encoded by a nucleic acid of the tables or a fragment thereof, the other one is for another antigen, and preferably for a cell-surface protein or receptor or receptor subunit, preferably one that is tumor specific.
  • the antibodies to cancer protein are capable of reducing or eliminating a biological function of a cancer protein, in a naked form or conjugated to an effector moiety, as is described below. That is, the addition of anti-cancer protein antibodies (either polyclonal or preferably monoclonal) to cancer tissue (or cells containing cancer) may reduce or eliminate the cancer.
  • at least a 25% decrease in activity, growth, size, or the like is prefened, with at least about 50% being particularly prefened and about a 95-100% decrease being especially prefened.
  • the antibodies to the cancer proteins are humanized antibodies (e.g., Xenerex Biosciences, Medarex, Inc., Abgenix, Inc., Protein Design Labs, Inc.)
  • Humanized forms of non-human (e.g., murine) antibodies are chimeric molecules of immunoglobulins, immunoglobulin chains or fragments thereof (such as Fv, Fab, Fab', F(ab')2 or other antigen-binding subsequences of antibodies) which contain minimal sequence derived from non-human immunoglobulin.
  • Humanized antibodies include human immunoglobulins (recipient antibody) in which residues from a complementary determining region (CDR) of the recipient are replaced by residues from a CDR of a non-human species (donor antibody) such as mouse, rat, or rabbit having the desired specificity, affinity, and capacity.
  • CDR complementary determining region
  • donor antibody such as mouse, rat, or rabbit having the desired specificity, affinity, and capacity.
  • Fv framework residues of a human immunoglobulin are replaced by conesponding non-human residues.
  • Humanized antibodies may also comprise residues which are found neither in the recipient antibody nor in the imported CDR or framework sequences.
  • a humanized antibody will comprise substantially all of at least one, and typically two, variable domains, in which all or substantially all of the CDR regions conespond to those of a non-human immunoglobulin and all or substantially all of the framework (FR) regions are those of a human immunoglobulin consensus sequence.
  • the humanized antibody optimally also will typically comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin (Jones, et al. (1986) Nature 321 :522-525; Riechmann, et al. (1988) Nature 332:323-329; and Presta (1992) Cun. Op. Struct. Biol. 2:593-596).
  • Humanization can be essentially performed following the method of Winter and co-workers (Jones, et al. (1986) Nature 321:522-525; Riechmann, et al. (1988) Nature 332:323-327; Verhoeyen, et al. (1988) Science 239:1534-1536), by substituting rodent CDRs or CDR sequences for conesponding sequences of a human antibody.
  • rodent CDRs or CDR sequences for conesponding sequences of a human antibody.
  • such humanized antibodies are chimeric antibodies (U.S. Patent No. 4,816,567), wherein substantially less than an intact human variable domain has been substituted by conesponding sequence from a non-human species.
  • Human antibodies can also be produced using phage display libraries (Hoogenboom and Winter (1992) J. Mol.
  • human antibodies can be made by introducing human immunoglobulin loci into transgenic animals, e.g., mice in which the endogenous immunoglobulin genes have been partially or completely inactivated.
  • immunotherapy is meant treatment of cancer with an antibody raised against cancer proteins.
  • immunotherapy can be passive or active.
  • Passive immunotherapy as defined herein is the passive transfer of antibody to a recipient (patient).
  • Active immunization is the induction of antibody and/or T-cell responses in a recipient (patient).
  • Induction of an immune response is the result of providing the recipient with an antigen to which antibodies are raised.
  • the antigen may be provided by injecting a polypeptide against which antibodies are desired to be raised into a recipient, or contacting the recipient with a nucleic acid capable of expressing the antigen and under conditions for expression of the antigen, leading to an immune response.
  • the cancer proteins against which antibodies are raised are secreted proteins as described above.
  • antibodies used for treatment may bind and prevent the secreted protein from binding to its receptor, thereby inactivating the secreted cancer protein, e.g., in autocrine signaling.
  • the cancer protein to which antibodies are raised is a transmembrane protein.
  • antibodies used for treatment may bind the extracellular domain of the cancer protein and prevent it from binding to other proteins, such as circulating ligands or cell-associated molecules.
  • the antibody may cause down- regulation of the transmembrane cancer protein.
  • the antibody may be a competitive, non- competitive or uncompetitive inhibitor of protein binding to the extracellular domain of the cancer protein.
  • the antibody may also be an antagonist of the cancer protein.
  • the antibody may prevent activation of the transmembrane cancer protein, or may induce or suppress a particular cellular pathway. In one aspect, when the antibody prevents the binding of other molecules to the cancer protein, the antibody prevents growth of the cell.
  • the antibody may also be used to target or sensitize the cell to cytotoxic agents, including, but not limited to TNF- ⁇ , TNF- ⁇ , IL-1, INF- ⁇ , and IL-2, or chemotherapeutic agents including 5FU, vinblastine, actinomycin D, cisplatin, methotrexate, and the like.
  • cytotoxic agents including, but not limited to TNF- ⁇ , TNF- ⁇ , IL-1, INF- ⁇ , and IL-2, or chemotherapeutic agents including 5FU, vinblastine, actinomycin D, cisplatin, methotrexate, and the like.
  • the antibody may belong to a sub-type that activates serum complement when complexed with the transmembrane protein thereby mediating cytotoxicity or antigen-dependent cytotoxicity (ADCC).
  • ADCC antigen-dependent cytotoxicity
  • cancer may be treated by administering to a patient antibodies directed against the transmembrane cancer protein.
  • Antibody-labeling may activate
  • the antibody is conjugated to an effector moiety.
  • the effector moiety can be various molecules, including labeling moieties such as radioactive labels or fluorescent labels, or can be a therapeutic moiety.
  • the therapeutic moiety is a small molecule that modulates the activity of a cancer protein.
  • the therapeutic moiety may modulate the activity of molecules associated with or in close proximity to a cancer protein.
  • the therapeutic moiety may inhibit enzymatic or signaling activity such as protease or collagenase or protein kinase activity associated with cancer, or be an attractant of other cells, such as NK cells.
  • the therapeutic moiety can also be a cytotoxic agent.
  • targeting the cytotoxic agent to cancer tissue or cells results in a reduction in the number of afflicted cells, thereby reducing symptoms associated with cancer.
  • Cytotoxic agents are numerous and varied and include, but are not limited to, cytotoxic drugs or toxins or active fragments of such toxins. Suitable toxins and their conesponding fragments include diphtheria A chain, exotoxin A chain, ricin A chain, abrin A chain, curcin, crotin, phenomycin, enomycin, saporin, auristatin, and the like.
  • Cytotoxic agents also include radiochemicals made by conjugating radioisotopes to antibodies raised against cancer proteins, or binding of a radionuclide to a chelating agent that has been covalently attached to the antibody.
  • Targeting the therapeutic moiety to transmembrane cancer proteins not only serves to increase the local concentration of therapeutic moiety in the cancer afflicted area, but also serves to reduce deleterious side effects that may be associated with the untargeted therapeutic moiety.
  • the cancer protein against which the antibodies are raised is an intracellular protein.
  • the antibody may be conjugated to a protein which facilitates entry into the cell.
  • the antibody enters the cell by endocytosis.
  • a nucleic acid encoding the antibody is administered to the individual or cell.
  • an antibody thereto may contain a signal for that target localization, e.g., a nuclear localization signal.
  • the cancer antibodies of the invention specifically bind to cancer proteins.
  • “specifically bind” herein is meant that the antibodies bind to the protein with a K ⁇ of at least about 0.1 mM, more usually at least about 1 ⁇ M, preferably at least about 0.1 ⁇ M or better, and most preferably, 0.01 ⁇ M or better. Selectivity of binding to the specific target and not to related sequences is often also important. Detection of cancer sequence for diagnostic and therapeutic applications
  • the RNA expression levels of genes are determined for different cellular states in the cancer phenotype. Expression levels of genes in normal tissue (e.g., not undergoing cancer) and in cancer tissue (and in some cases, for varying severities of cancer that relate to prognosis, as outlined below), or in non-malignant disease are evaluated to provide expression profiles.
  • a gene expression profile of a particular cell state or point of development is essentially a "finge ⁇ rint" of the state of the cell. While two states may have a particular gene similarly expressed, the evaluation of a number of genes simultaneously allows the generation of a gene expression profile that is reflective of the state of the cell.
  • differential expression refers to qualitative or quantitative differences in the temporal and/or cellular gene expression patterns within and among cells and tissue.
  • a differentially expressed gene can qualitatively have its expression altered, including an activation or inactivation, in, e.g., normal versus cancer tissue.
  • Genes may be turned on or turned off in a particular state, relative to another state thus permitting comparison of two or more states.
  • a qualitatively regulated gene will exhibit an expression pattern within a state or cell type which is detectable by standard techniques. Some genes will be expressed in one state or cell type, but not in both.
  • the difference in expression may be quantitative, e.g., in that expression is increased or decreased; e.g., gene expression is either upregulated, resulting in an increased amount of transcript, or downregulated, resulting in a decreased amount of transcript.
  • the degree to which expression differs need only be large enough to quantify via standard characterization techniques as outlined below, such as by use of Affymetrix GeneChipTM expression anays. See, Lockhart (1996) Nature Biotechnology 14:1675-1680.
  • Other techniques include, but are not limited to, quantitative reverse transcriptase PCR, northern analysis, and RNase protection.
  • the change in expression is at least about 50%, more preferably at least about 100%, more preferably at least about 150%, more preferably at least about 200%, with from 300 to at least 1000% being especially prefened.
  • Evaluation may be at the gene transcript or the protein level.
  • the amount of gene expression may be monitored using nucleic acid probes to the RNA or DNA equivalent of the gene transcript, and the quantification of gene expression levels, or, alternatively, the final gene product itself (protein) can be monitored, e.g., with antibodies to the cancer protein and standard immunoassays (ELIS As, etc.) or other techniques, including mass spectroscopy assays, 2D gel electrophoresis assays, etc.
  • ELIS As standard immunoassays
  • Proteins conesponding to cancer genes can be evaluated in a cancer diagnostic test.
  • gene expression monitoring is performed simultaneously on a number of genes. Multiple protein expression monitoring can be performed as well.
  • the cancer nucleic acid probes are attached to biochips as outlined herein for the detection and quantification of cancer sequences in a particular cell.
  • the assays are further described below in the example. PCR techniques can be used to provide greater sensitivity.
  • nucleic acids encoding the cancer protein are detected.
  • DNA or RNA encoding the cancer protein may be detected, of particular interest are methods wherein an mRNA encoding a cancer protein is detected.
  • Probes to detect mRNA can be a nucleotide/deoxynucleotide probe that is complementary to and hybridizes with the mRNA and includes, but is not limited to, oligonucleotides, cDNA, or RNA. Probes also should contain a detectable label, as defined herein.
  • the mRNA is detected after immobilizing the nucleic acid to be examined on a solid support such as nylon membranes and hybridizing the probe with the sample.
  • RNA probe digoxygenin labeled riboprobe
  • RNA probe that is complementary to the mRNA encoding a cancer protein is detected by binding the digoxygenin with an anti-digoxygenin secondary antibody and developed with nitro blue tetrazolium and 5-bromo-4-chloro-3-indoyl phosphate.
  • various proteins from the three classes of proteins as described herein are used in diagnostic assays.
  • the cancer proteins, antibodies, nucleic acids, modified proteins, and cells containing cancer sequences are used in diagnostic assays. This can be performed on an individual gene or conesponding polypeptide level.
  • the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes and/or conesponding polypeptides.
  • cancer proteins including intracellular, transmembrane, or secreted proteins, find use as markers of cancer, e.g., for prognostic or diagnostic pmrposes. Detection of these proteins in putative cancer tissue allows for detection, prognosis, or diagnosis of cancer or similar disease, and for selection of therapeutic strategy.
  • antibodies are used to detect cancer proteins.
  • a prefened method separates proteins from a sample by electrophoresis on a gel (typically a denaturing and reducing protein gel, but may be another type of gel, including isoelectric focusing gels and the like). Following separation of proteins, the cancer protein is detected, e.g., by immunoblotting with antibodies raised against the cancer protein.
  • antibodies to the cancer protein find use in in situ imaging techniques, e.g., in histology. See, e.g., Asai, et al. (eds. 1993) Methods in Cell Biology: Antibodies in Cell Biology (vol. 37) Academic Press.
  • cells are contacted with from one to many antibodies to the cancer protein(s). Following washing to remove nonspecific antibody binding, the presence of the antibody or antibodies is detected.
  • the antibody is detected by incubating with a secondary antibody that contains a detectable label.
  • the primary antibody to the cancer protein(s) contains a detectable label, e.g., an enzyme marker that can act on a substrate.
  • each one of multiple primary antibodies contains a distinct and detectable label. This method finds particular use in simultaneous screening for a plurality of cancer proteins. Many other histological imaging techniques are also provided by the invention.
  • the label is detected in a fluorometer which has the ability to detect and distinguish emissions of different wavelengths.
  • a fluorescence activated cell sorter FACS
  • FACS fluorescence activated cell sorter
  • antibodies find use in diagnosing cancer from blood, serum, plasma, stool, and other samples. Such samples, therefore, are useful as samples to be probed or tested for the presence of cancer proteins.
  • Antibodies can be used to detect a cancer protein by previously described immunoassay techniques including ELISA, immunoblotting (western blotting), immunoprecipitation, BIACORE technology and the like. Conversely, the presence of antibodies may indicate an immune response against an endogenous cancer protein.
  • in situ hybridization of labeled cancer nucleic acid probes to tissue anays is done. For example, anays of tissue samples, including cancer tissue and/or normal tissue, are made.
  • In situ hybridization (see, e.g., Ausubel, supra) is then performed.
  • a diagnosis, a prognosis, or a prediction may be based on the findings. It is further understood that the genes which indicate the diagnosis may differ from those which indicate the prognosis and molecular profiling of the condition of the cells may lead to distinctions between responsive or refractory conditions or may be predictive of outcomes.
  • the cancer proteins, antibodies, nucleic acids, modified proteins, and cells containing cancer sequences are used in prognosis assays.
  • gene expression profiles can be generated that conelate to cancer, clinical, pathological, or other information, in terms of long term prognosis. Again, this may be done on either a protein or gene level, with the use of genes being prefened. Single or multiple genes may be useful in various combinations.
  • cancer probes may be attached to biochips for the detection and quantification of cancer sequences in a tissue or patient. The assays proceed as outlined above for diagnosis. PCR method may provide more sensitive and accurate quantification. Assays for therapeutic compounds
  • the proteins, nucleic acids, and antibodies as described herein are used in drug screening assays.
  • the cancer proteins, antibodies, nucleic acids, modified proteins, and cells containing cancer sequences are used in drug screening assays or by evaluating the effect of drug candidates on a "gene expression profile" or expression profile of polypeptides.
  • the expression profiles are used, preferably in conjunction with high throughput screening techniques, to allow monitoring for expression profile genes after treatment with a candidate agent (e.g., Zlokarnik, et al. (1998) Science 279:84-88; Heid (1996) Genome Res. 6:986-994.
  • the cancer proteins, antibodies, nucleic acids, modified proteins and cells containing the native or modified cancer proteins are used in screening assays. That is, the present invention provides novel methods for screening for compositions which modulate the cancer phenotype or an identified physiological function of a cancer protein. As above, this can be done on an individual gene level or by evaluating the effect of drug candidates on a "gene expression profile".
  • the expression profiles are used, preferably in conjunction with high throughput screening techniques, to allow monitoring for expression profile genes after treatment with a candidate agent, see Zlokarnik, supra.
  • assays may be nm on an individual gene or protein level. That is, having identified a particular gene as up regulated in cancer, test compounds can be screened for the ability to modulate gene expression or for binding to the cancer protein. "Modulation" thus includes both an increase and a decrease in gene expression. The prefened amount of modulation will depend on the original change of the gene expression in normal versus tissue undergoing cancer, with changes of at least 10%, preferably 50%, more preferably 100-300%, and in some embodiments 300-1000% or greater.
  • a gene exhibits a 4-fold increase in cancer tissue compared to normal tissue, a decrease of about four-fold is often desired; similarly, a 10-fold decrease in cancer tissue compared to normal tissue often provides a target value of a 10-fold increase in expression to be induced by the test compound.
  • the amount of gene expression may be monitored using nucleic acid probes and the quantification of gene expression levels, or, alternatively, the gene product itself can be monitored, e.g., through the use of antibodies to the cancer protein and standard immunoassays. Proteomics and separation techniques may also allow quantification of expression.
  • gene expression or protein monitoring of a number of entities e.g., an expression profile
  • Such profiles will typically involve a plurality of those entities described herein.
  • the cancer nucleic acid probes are attached to biochips as outlined herein for the detection and quantification of cancer sequences in a particular cell.
  • PCR may be used.
  • a series e.g., of microtiter plate, may be used with dispensed primers in desired wells. A PCR reaction can then be performed and analyzed for each well.
  • Expression monitoring can be performed to identify compounds that modify the expression of one or more cancer-associated sequences, e.g., a polynucleotide sequence set out in the tables.
  • a test modulator is added to the cells prior to analysis.
  • screens are also provided to identify agents that modulate cancer, modulate cancer proteins, bind to a cancer protein, or interfere with the binding of a cancer protein and an antibody or other binding partner.
  • test compound or “drug candidate” or “modulator” or grammatical equivalents as used herein describes a molecule, e.g., protein, oligopeptide, small organic molecule, polysaccharide, polynucleotide, etc., to be tested for the capacity to directly or indirectly alter the cancer phenotype or the expression of a cancer sequence, e.g., a nucleic acid or protein sequence.
  • modulators alter expression profiles, or expression profile nucleic acids or protems provided herein.
  • the modulator suppresses a cancer phenotype, e.g., to a normal or non-malignant tissue fmge ⁇ rint.
  • a modulator induced a cancer phenotype.
  • a plurality of assay mixtures are run in parallel with different agent concentrations to obtain a differential response to the various concentrations.
  • one of these concentrations serves as a negative control, e.g., at zero concentration or below the level of detection.
  • Drug candidates encompass numerous chemical classes, though typically they are organic molecules, preferably small organic compounds having a molecular weight of more than 100 and less than about 2,500 daltons. Prefened small molecules are less than 2000, or less than 1500, or less than 1000, or less than 500 D.
  • Candidate agents comprise functional groups necessary for structural interaction with proteins, particularly hydrogen bonding, and typically include at least an amine, carbonyl, hydroxyl or carboxyl group, preferably at least two of the functional chemical groups.
  • the candidate agents often comprise cyclical carbon or heterocyclic structures and/or aromatic or polyaromatic structures substituted with one or more of the above functional groups.
  • Candidate agents are also found among biomolecules including peptides, saccharides, fatty acids, steroids, purines, pyrimidines, derivatives, structural analogs, or combinations thereof. Particularly prefened are peptides.
  • a modulator will neutralize the effect of a cancer protein.
  • neutralize is meant that activity of a protein is inhibited or blocked and the consequent effect on the cell.
  • combinatorial libraries of potential modulators will be screened for an ability to bind to a cancer polypeptide or to modulate activity.
  • new chemical entities with useful properties are generated by identifying a chemical compound (called a “lead compound") with some desirable property or activity, e.g., inhibiting activity, creating variants of the lead compound, and evaluating the property and activity of those variant compounds.
  • HTS high throughput screening
  • high throughput screening methods involve providing a library containing a large number of potential therapeutic compounds (candidate compounds). Such "combinatorial chemical libraries” are then screened in one or more assays to identify those library members (particular chemical species or subclasses) that display a desired characteristic activity. The compounds thus identified can serve as conventional "lead compounds” or can themselves be used as potential or actual therapeutics.
  • a combinatorial chemical library is a collection of diverse chemical compounds generated by either chemical synthesis or biological synthesis by combining a number of chemical "building blocks" such as reagents.
  • a linear combinatorial chemical library such as a polypeptide (e.g., mutein) library, is formed by combining a set of chemical building blocks called amino acids in every possible way for a given compound length (e.g., the number of amino acids in a polypeptide compound). Millions of chemical compounds can be synthesized through such combinatorial mixing of chemical building blocks (Gallop, et al. (1994) J. Med. Chem. 37:1233-1251).
  • combinatorial chemical libraries include, but are not limited to, peptide libraries (see, e.g., U.S. Patent No. 5,010,175, Furka (1991) Pept. Prot. Res. 37:487-493, Houghton, et al. (1991) Nature 354:84-88), peptoids (PCT Publication No WO 91/19735), encoded peptides (PCT Publication WO 93/20242), random bio-oligomers (PCT Publication WO 92/00091), benzodiazepines (U.S. Pat. No.
  • the assays to identify modulators are amenable to high throughput screening. Prefened assays thus detect enhancement or inhibition of cancer gene transcription, inhibition, or enhancement of polypeptide expression, and inhibition or enhancement of polypeptide activity.
  • High throughput assays for the presence, absence, quantification, or other properties of particular nucleic acids or protein products are well known.
  • binding assays and reporter gene assays are similarly well known.
  • U.S. Patent No. 5,559,410 discloses high throughput screening methods for proteins
  • U.S. Patent No. 5,585,639 discloses high throughput screening methods for nucleic acid binding (e.g., in anays)
  • U.S. Patent Nos. 5,576,220 and 5,541,061 disclose high throughput methods of screening for ligand/antibody binding.
  • high throughput screening systems are commercially available (see, e.g., Zymark Co ⁇ ., Hopkinton, MA; Air Technical Industries, Mentor, OH; Beckman Instruments, Inc. Fullerton, CA; Precision Systems, Inc., Natick, MA, etc.). These systems typically automate entire procedures, including sample and reagent pipetting, liquid dispensing, timed incubations, and final readings of the microplate in detector(s) appropriate for the assay.
  • These configurable systems provide high throughput and rapid start up as well as a high degree ⁇ of flexibility and customization. The manufacturers of such systems provide detailed protocols for various high throughput systems.
  • Zymark Co ⁇ provides technical bulletins describing screening systems for detecting the modulation of gene transcription, ligand binding, and the like.
  • modulators are proteins, often naturally occurring proteins or fragments of naturally occurring proteins.
  • cellular extracts containing proteins, or random or directed digests of proteinaceous cellular extracts may be used.
  • libraries of proteins may be made for screening in the methods of the invention.
  • Particularly prefened in this embodiment are libraries of bacterial, fungal, viral, and mammalian proteins, with the latter being prefened, and human proteins being especially prefened.
  • Particularly useful test compound will be directed to the class of proteins to which the target belongs, e.g., substrates for enzymes or ligands and receptors.
  • modulators are peptides of from about 5-30 amino acids, with from about 5-20 amino acids being prefened, and from about 7-15 being particularly prefened.
  • the peptides may be digests of naturally occurring proteins, random peptides, or "biased” random peptides.
  • randomized or grammatical equivalents herein is meant that each nucleic acid and peptide consists of essentially random nucleotides and amino acids, respectively. Since generally these random peptides (or nucleic acids, discussed below) are chemically synthesized, they may inco ⁇ orate a nucleotide or amino acid at any position.
  • the synthetic process can be designed to generate randomized proteins or nucleic acids, to allow the formation of all or most of the possible combinations over the length of the sequence, thus forming a library of randomized candidate bioactive proteinaceous agents.
  • the library is fully randomized, with no sequence preferences or constants at any position.
  • the library is biased. That is, some positions within the sequence are either held constant, or are selected from a limited number of possibilities.
  • the nucleotides or amino acid residues are randomized within a defined class, e.g., of hydrophobic amino acids, hydrophilic residues, sterically biased (either small or large) residues, towards the creation of nucleic acid binding domains, the creation of cysteines, for cross-linking, prolines for SH-3 domains, serines, threonines, tyrosines, or histidines for phosphorylation sites, etc., or to purines, etc.
  • Modulators of cancer can also be nucleic acids, as defined above.
  • nucleic acid modulating agents may be naturally occurring nucleic acids, random nucleic acids, or "biased" random nucleic acids.
  • digests of prokaryotic or eukaryotic genomes may be used as is outlined above for proteins.
  • the candidate compounds are organic chemical moieties, a wide variety of which are available in the literature.
  • the sample containing a target sequence to be analyzed is added to the biochip.
  • the target sequence is prepared using known techniques.
  • the sample may be treated to lyse the cells, using known lysis buffers, electroporation, etc., with purification and/or amplification such as PCR performed as appropriate.
  • an in vitro transcription with labels covalently attached to the nucleotides is performed.
  • the nucleic acids are labeled with biotin-FITC or PE, or with cy3 or cy5.
  • the target sequence is labeled with, e.g., a fluorescent, a chemiluminescent, a chemical, or a radioactive signal, to provide a means of detecting the target sequence's specific binding to a probe.
  • the label also can be an enzyme, such as, alkaline phosphatase or horseradish peroxidase, which when provided with an appropriate substrate produces a product that can be detected.
  • the label can be a labeled compound or small molecule, such as an enzyme inhibitor, that binds but is not catalyzed or altered by the enzyme.
  • the label also can be a moiety or compound, such as, an epitope tag or biotin which specifically binds to streptavidin.
  • the streptavidin is labeled as described above, thereby, providing a detectable signal for the bound target sequence. Unbound labeled streptavidin is typically removed prior to analysis.
  • assays can be direct hybridization assays or can comprise "sandwich assays", which include the use of multiple probes, as is generally outlined in U.S. Patent Nos. 5,681,702, 5,597,909, 5,545,730, 5,594,117, 5,591,584, 5,571,670, 5,580,731, 5,571,670, 5,591,584,
  • the target nucleic acid is prepared as outlined above, and then added to the biochip comprising a plurality of nucleic acid probes, under conditions that allow the formation of a hybridization complex.
  • hybridization conditions may be used in the present invention, including high, moderate, and low stringency conditions as outlined above.
  • the assays are generally run under stringency conditions which allows formation of the label probe hybridization complex only in the presence of target. Stringency can be controlled by altering a step parameter that is a thermodynamic variable, including, but not limited to, temperature, formamide concentration, salt concentration, chaotropic salt concentration, pH, organic solvent concentration, etc.
  • the reactions outlined herein may be accomplished in a variety of ways. Components of the reaction may be added simultaneously, or sequentially, in different orders, with prefened embodiments outlined below.
  • the reaction may include a variety of other reagents. These include salts, buffers, neutral proteins, e.g., albumin, detergents, etc. which may be used to facilitate optimal hybridization and detection, and/or reduce non-specific or background interactions. Reagents that otherwise improve the efficiency of the assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., may also be used as appropriate, depending on the sample preparation methods and purity of the target.
  • the assay data are analyzed to determine the expression levels, and changes in expression levels as between states of individual genes, forming a gene expression profile.
  • Screens are performed to identify modulators of the cancer phenotype.
  • screening is performed to identify modulators that can induce or suppress a particular expression profile, thus preferably generating the associated phenotype.
  • screens can be performed to identify modulators that alter expression of individual genes.
  • screening is performed to identify modulators that alter a biological function of the expression product of a differentially expressed gene. Again, having identified the importance of a gene in a particular state, screens are performed to identify agents that bind and/or modulate the biological activity of the gene product.
  • screens can be done for genes that are induced in response to a candidate agent or treatment process. After identifying a modulator based upon its ability to suppress a cancer expression pattern leading to a normal expression pattern (or its converse), or to modulate a single cancer gene expression profile so as to mimic the expression of the gene from normal tissue, a screen as described above can be performed to identify genes that are specifically modulated in response to the agent. Comparing expression profiles between normal tissue and agent treated cancer tissue reveals genes that are not expressed in normal tissue or cancer tissue, but are expressed in agent treated tissue.
  • agent-specific sequences can be identified and used by methods described herein for cancer genes or proteins. In particular, these sequences and the proteins they encode find use in marking or identifying agent treated cells.
  • antibodies can be raised against the agent induced proteins and used to target novel therapeutics to the treated cancer tissue sample.
  • a test compound is administered to a population of cancer cells that have an associated cancer expression profile.
  • administration or “contacting” herein is meant that the candidate agent is added to the cells in such a manner as to allow the agent to act upon the cell, whether by uptake and intracellular action, or by action at the cell surface.
  • nucleic acid encoding a proteinaceous candidate agent e.g., a peptide
  • a viral construct such as an adenoviral or retroviral construct
  • Regulatable gene therapy systems can also be used.
  • cancer or non-malignant tissue may be screened for agents that modulate, e.g., induce or suppress a cancer phenotype.
  • a change in at least one gene, preferably many, of the expression profile indicates that the agent has an effect on cancer activity.
  • screens may be done on individual genes and gene products (proteins). That is, having identified a particular differentially expressed gene as important in a particular state, screening of modulators of either the expression of the gene or the gene product itself can be done.
  • the gene products of differentially expressed genes are sometimes refened to herein as "cancer proteins” or a "cancer modulatory protein".
  • the cancer modulatory protein may be a fragment, or alternatively, be the full length protein to the fragment encoded by the nucleic acids of the Tables.
  • the cancer modulatory protein is a fragment.
  • the cancer amino acid sequence which is used to determine sequence identity or similarity is encoded by a nucleic acid of the Tables.
  • the sequences are naturally occurring allelic variants of a protein encoded by a nucleic acid of the Tables.
  • the sequences are sequence variants as further described herein.
  • the cancer modulatory protein is a fragment of about 14-24 amino acids long. More preferably the fragment is a soluble fragment. Preferably, the fragment includes a non-transmembrane region. In a prefened embodiment, the fragment has an N-terminal Cys to aid in solubility. In one embodiment, the C-terminus of the fragment is kept as a free acid and the N-terminus is a free amine to aid in coupling, e.g., to cysteine. In one embodiment the cancer proteins are conjugated to an immunogenic agent as discussed herein. In one embodiment the cancer protein is conjugated to BSA.
  • Measurements of cancer polypeptide activity, or of cancer or the cancer phenotype can be performed using a variety of assays.
  • the effects of the test compounds upon the function of the cancer polypeptides can be measured by examining parameters described above.
  • a suitable physiological change that affects activity can be used to assess the influence of a test compound on the polypeptides of this invention.
  • cancer polypeptide is typically used, e.g., mouse, preferably human.
  • Assays to identify compounds with modulating activity can be performed in vitro.
  • a cancer polypeptide is first contacted with a potential modulator and incubated for a suitable amount of time, e.g., from 0.5-48 hours.
  • the cancer polypeptide levels are determined in vitro by measuring the level of protein or mRNA.
  • the level of protein is typically measured using immunoassays such as western blotting, ELISA, and the like with an antibody that selectively binds to the cancer polypeptide or a fragment thereof.
  • amplification e.g., using PCR, LCR, or hybridization assays, e.g., northern hybridization, RNAse protection, dot blotting
  • the level of protein or mRNA is typically detected using directly or indirectly labeled detection agents, e.g., fluorescently or radioactively labeled nucleic acids, radioactively or enzymatically labeled antibodies, and the like, as described herein.
  • a reporter gene system can be devised using a cancer protein promoter operably linked to a reporter gene such as luciferase, green fluorescent protein, CAT, or -gal. The reporter construct is typically transfected into a cell.
  • the amount of reporter gene transcription, translation, or activity is measured according to standard techniques.
  • screens may be done on individual genes and gene products (proteins). That is, having identified a particular differentially expressed gene as important in a particular state, screening of modulators of the expression of the gene or the gene product itself can be done.
  • the gene products of differentially expressed genes are sometimes refened to herein as "cancer proteins.”
  • the cancer protein may be a fragment, or alternatively, the full length protein to a fragment shown herein.
  • screening for modulators of expression of specific genes is performed. Typically, the expression of only one or a few genes are evaluated. In another embodiment, screens are designed to first find compounds that bind to differentially expressed proteins. These compounds are then evaluated for the ability to modulate differentially expressed activity. Moreover, once initial candidate compounds are identified, variants can be further screened to better evaluate structure activity relationships. In a prefened embodiment, binding assays are done. In general, purified or isolated gene product is used; that is, the gene products of one or more differentially expressed nucleic acids are made. For example, antibodies are generated to the protein gene products, and standard immunoassays are run to determine the amount of protein present. Alternatively, cells comprising the cancer proteins can be used in the assays.
  • the methods comprise combining a cancer protein and a candidate compound, and determining the binding of the compound to the cancer protein.
  • Prefened embodiments utilize the human cancer protein, although other mammalian proteins may also be used, e.g., for the development of animal models of human disease.
  • variant or derivative cancer proteins may be used.
  • the cancer protein or the candidate agent is non-diffusably bound to an insoluble support, preferably having isolated sample receiving areas (e.g., a microtiter plate, an anay, etc.).
  • the insoluble supports may be made of a composition to which the compositions can be bound, is readily separated from soluble material, and is otherwise compatible with the overall method of screening.
  • the surface of such supports may be solid or porous and of a convenient shape.
  • suitable insoluble supports include microtiter plates, anays, membranes, and beads. These are typically made of glass, plastic (e.g., polystyrene), polysaccharides, nylon or nitrocellulose, teflonTM, etc. Microtiter plates and anays are especially convenient because a large number of assays can be carried out simultaneously, using small amounts of reagents and samples.
  • the particular manner of binding of the composition is typically not crucial so long as it is compatible with the reagents and overall methods of the invention, maintains the activity of the composition, and is nondiffusable.
  • Prefened methods of binding include the use of antibodies (which do not sterically block either the ligand binding site or activation sequence when the protein is bound to the support), direct binding to "sticky" or ionic supports, chemical crosslinking, the synthesis of the protein or agent on the surface, etc. Following binding of the protein or agent, excess unbound material is removed by washing. The sample receiving areas may then be blocked through incubation with bovine serum albumin (BSA), casein, or other innocuous protein or other moiety.
  • BSA bovine serum albumin
  • the cancer protein is bound to the support, and a test compound is added to the assay.
  • the candidate agent is bound to the support and the cancer protein is added.
  • Novel binding agents include specific antibodies, non-natural binding agents identified in screens of chemical libraries, peptide analogs, etc. Of particular interest are screening assays for agents that have a low toxicity for human cells. A wide variety of assays may be used for this pu ⁇ ose, including labeled in vitro protein-protein binding assays, electrophoretic mobility shift assays, immunoassays for protein binding, functional assays (phosphorylation assays, etc.), and the like.
  • the determination of the binding of the test modulating compound to the cancer protein may be done in a number of ways.
  • the compound is labeled, and binding determined directly, e.g., by attaching all or a portion of the cancer protein to a solid support, adding a labeled candidate agent (e.g., a fluorescent label), washing off excess reagent, and determining whether the label is present on the solid support.
  • a labeled candidate agent e.g., a fluorescent label
  • washing off excess reagent e.g., a fluorescent label
  • Various blocking and washing steps may be utilized as appropriate.
  • the proteins can be labeled.
  • more than one component can be labeled with different labels, e.g., 125j_ f or t e proteins and a fluorophor for the compound.
  • Proximity reagents e.g., quenching or energy transfer reagents are also useful.
  • the binding of the test compound is determined by competitive binding assay.
  • the competitor may be a binding moiety known to bind to the target molecule (e.g., a cancer protein), such as an antibody, peptide, binding partner, ligand, etc.
  • the test compound is labeled. Either the compound, or the competitor, or both, is added first to the protein for a time sufficient to allow binding, if present. Incubations may be performed at a temperature which facilitates optimal activity, typically between about 4-40° C. Incubation periods are typically optimized, e.g., to facilitate rapid high throughput screening. Typically between 0.1-1 hour will be sufficient. Excess reagent is generally removed or washed away. The second component is then added, and the presence or absence of the labeled component is followed, to indicate binding. In a prefened embodiment, the competitor is added first, followed by a test compound.
  • Displacement of the competitor is an indication that the test compound is binding to the cancer protein and thus is capable of binding to, and potentially modulating, the activity of the cancer protein.
  • either component can be labeled.
  • the presence of label in the wash solution indicates displacement by the agent.
  • the presence of the label on the support indicates displacement.
  • test compound is added first, with incubation and washing, followed by the competitor.
  • the absence of binding by the competitor may indicate that the test compound is bound to the cancer protein with a higher affinity.
  • the presence of the label on the support, coupled with a lack of competitor binding may indicate that the test compound is capable of binding to the cancer protein.
  • the methods comprise differential screening to identity agents that are capable of modulating the activity of the cancer proteins.
  • the methods comprise combining a cancer protein and a competitor in a first sample.
  • a second sample comprises a test compound, a cancer protein, and a competitor.
  • the binding of the competitor is determined for both samples, and a change, or difference in binding between the two samples indicates the presence of an agent capable of binding to the cancer protein and potentially modulating its activity. That is, if the binding of the competitor is different in the second sample relative to the first sample, the agent is capable of binding to the cancer protein.
  • differential screening is used to identify drug candidates that bind to the native cancer protein, but cannot bind to modified cancer proteins.
  • the structure of the cancer protein may be modeled, and used in rational drug design to synthesize agents that interact with that site.
  • Drug candidates that affect the activity of a cancer protein are also identified by screening drugs for the ability to either enhance or reduce the activity of the protein.
  • Positive controls and negative controls may be used in the assays.
  • Preferably control and test samples are performed in at least triplicate to obtain statistically significant results. Incubation of all samples is for a time sufficient for the binding of the agent to the protein. Following incubation, samples are washed free of non-specifically bound material and the amount of bound, generally labeled agent determined. For example, where a radiolabel is employed, the samples may be counted in a scintillation counter to determine the amount of bound compound.
  • reagents may be included in the screening assays. These include reagents like salts, neutral proteins, e.g., albumin, detergents, etc., which may be used to facilitate optimal protein-protein binding and/or reduce non-specific or background interactions. Also reagents that otherwise improve the efficiency of the assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., maybe used. The mixture of components may be added in an order that provides for the requisite binding.
  • the invention provides methods for screening for a compound capable of modulating the activity of a cancer protein.
  • the methods comprise adding a test compound, as defined above, to a cell comprising cancer proteins.
  • Prefened cell types include almost any cell.
  • the cells contain a recombinant nucleic acid that encodes a cancer protein.
  • a library of candidate agents are tested on a plurality of cells.
  • the assays are evaluated in the presence or absence or previous or subsequent exposure of physiological signals, e.g., hormones, antibodies, peptides, antigens, cytokines, growth factors, action potentials, pharmacological agents including chemotherapeutics, radiation, carcinogenics, or other cells (e.g., cell-cell contacts).
  • physiological signals e.g., hormones, antibodies, peptides, antigens, cytokines, growth factors, action potentials, pharmacological agents including chemotherapeutics, radiation, carcinogenics, or other cells (e.g., cell-cell contacts).
  • the determinations are determined at different stages of the cell cycle process.
  • a method of inhibiting cancer cell division comprises administration of a cancer inhibitor.
  • a method of inhibiting cancer is provided.
  • the method may comprise administration of a cancer inhibitor.
  • methods of treating cells or individuals with cancer are provided, e.g., comprising administration of a cancer inhibitor.
  • a cancer inhibitor is an antibody as discussed above. In another embodiment, the cancer inhibitor is an antisense molecule.
  • a variety of cell growth, proliferation, viability, and metastasis assays are available, as described below. Soft agar growth or colony formation in suspension
  • Normal cells require a solid substrate to attach and grow. When the cells are transformed, they lose this phenotype and grow detached from the substrate.
  • transformed cells can grow in stined suspension culture or suspended in semi-solid media, such as semi-solid or soft agar.
  • the transformed cells when transfected with tumor suppressor genes, regenerate normal phenotype and require a solid substrate to attach and grow.
  • Soft agar growth or colony formation in suspension assays can be used to identify modulators of cancer sequences, which when expressed in host cells, inhibit abnormal cellular proliferation and transformation.
  • a therapeutic compound would reduce or eliminate the host cells' ability to grow in stined suspension culture or suspended in semi-solid media, such as semi-solid or soft.
  • Normal cells typically grow in a flat and organized pattern in a petri dish until they touch other cells. When the cells touch one another, they are contact inhibited and stop growing. When cells are transformed, however, the cells are not contact inhibited and continue to grow to high densities in disorganized foci. Thus, the transformed cells grow to a higher saturation density than normal cells. This can be detected mo ⁇ hologically by the formation of a disoriented monolayer of cells or rounded cells in foci within the regular pattern of normal sunounding cells. Alternatively, labeling index with ( ⁇ HHhymidine at saturation density can be used to measure density limitation of growth. See Freshney (2000), supra. The transformed cells, when transfected with tumor suppressor genes, regenerate a normal phenotype and become contact inhibited and would grow to a lower density.
  • labeling index with (3H)-thymidine at saturation density is a prefened method of measuring density limitation of growth.
  • Transformed host cells are transfected with a cancer-associated sequence and are grown for 24 hours at saturation density in non-limiting medium conditions.
  • the percentage of cells labeling with (3H)-thymidine is determined autoradiographically. See, Freshney (1998), supra. Growth factor or serum dependence
  • Transformed cells typically have a lower serum dependence than their normal counte ⁇ arts (see, e.g., Temin (1966) J. Natl. Cancer Insti. 37:167-175; Eagle, et al.(1970) J.
  • Tumor cells release an increased amount of certain factors (hereinafter “tumor specific markers”) than their normal counte ⁇ arts.
  • tumor specific markers For example, plasminogen activator (PA) is released from human glioma at a higher level than from normal brain cells (see, e.g., Gullino
  • tumor angiogenesis factor (TAF) is released at a higher level in tumor cells than their normal . counte ⁇ arts. See, e.g., Folkman (1992) Sem. Cancer Biol. 3:89-96. Various techniques which measure the release of these factors are described in Freshney
  • the degree of invasiveness into Matrigel or some other extracellular matrix constituent can be used as an assay to identify compounds that modulate cancer-associated sequences.
  • Tumor cells exhibit a good conelation between malignancy and invasiveness of cells into Matrigel or some other extracellular matrix constituent.
  • tumorigenic cells are typically used as host cells. Expression of a tumor suppressor gene in these host cells would decrease invasiveness of the host cells.
  • the level of invasion of host cells can be measured by using filters coated with Matrigel or some other extracellular matrix constituent. Penetration into the gel, or through to the distal side of the filter, is rated as invasiveness, and rated histologically by number of cells and distance moved, or by prelabeling the cells with 125j an d counting the radioactivity on the distal side of the filter or bottom of the dish. See, e.g., Freshney (1984), supra. Tumor growth in vivo
  • Knock-out transgenic mice can be made, in which the cancer gene is disrupted or in which a cancer gene is inserted.
  • Knock-out transgenic mice can be made by insertion of a marker gene or other heterologous gene into the endogenous cancer gene site in the mouse genome via homologous recombination.
  • Such mice can also be made by substituting the endogenous cancer gene with a mutated version of the cancer gene, or by mutating the endogenous cancer gene, e.g., by exposure to carcinogens.
  • a DNA construct is introduced into the nuclei of embryonic stem cells.
  • Cells containing the newly engineered genetic lesion are injected into a host mouse embryo, which is reimplanted into a recipient female. Some of these embryos develop into chimeric mice that possess germ cells partially derived from the mutant cell line. Therefore, by breeding the chimeric mice it is possible to obtain a new line of mice containing the introduced genetic lesion (see, e.g., Capecchi, et al. (1989) Science 244:1288-1292).
  • Chimeric targeted mice can be derived according to Hogan, et al. (1988) Manipulating the Mouse Embryo: A Laboratory Manual CSH Press; and Robertson (ed.
  • Transplantable tumor cells typically about 10" cells
  • injected into isogenic hosts will produce invasive tumors in a high proportions of cases, while normal cells of similar origin will not.
  • cells expressing a cancer-associated sequences are injected subcutaneously.
  • tumor growth is measured (e.g., by volume or by its two largest dimensions) and compared to the control. Tumors that have statistically significant reduction (using, e.g., Student's T test) are said to have inhibited growth.
  • the activity of a cancer-associated protein is down-regulated, or entirely inhibited, by the use of an inhibitory or antisense polynucleotide, e.g., a nucleic acid complementary to, and which can preferably hybridize specifically to, a coding mRNA nucleic acid sequence, e.g., a cancer protein mRNA, or a subsequence thereof. Binding of the antisense polynucleotide to the mRNA reduces the translation and/or stability of the mRNA.
  • an inhibitory or antisense polynucleotide e.g., a nucleic acid complementary to, and which can preferably hybridize specifically to, a coding mRNA nucleic acid sequence, e.g., a cancer protein mRNA, or a subsequence thereof. Binding of the antisense polynucleotide to the mRNA reduces the translation and/or stability of the mRNA.
  • antisense polynucleotides can comprise naturally- occurring nucleotides, or synthetic species formed from naturally-occurring subunits or their close homologs. Antisense polynucleotides may also have altered sugar moieties or inter-sugar linkages. Exemplary among these are the phosphorothioate and other sulfur containing species. Analogs are comprehended by this invention so long as they function effectively to hybridize with the cancer protein mRNA. See, e.g., Isis Pharmaceuticals, Carlsbad, CA; Sequitor, Inc., Natick, MA. Such antisense polynucleotides can readily be synthesized using recombinant means, or can be synthesized in vitro. Equipment for such synthesis is sold by several vendors, including Applied Biosystems. The preparation of other oligonucleotides such as phosphorothioates and alkylated derivatives is also well known.
  • Antisense molecules as used herein include antisense or sense oligonucleotides.
  • Sense oligonucleotides can, e.g., be employed to block transcription by binding to the anti-sense strand.
  • the antisense and sense oligonucleotide comprise a single-stranded nucleic acid sequence (either RNA or DNA) capable of binding to target mRNA (sense) or DNA (antisense) sequences for cancer molecules.
  • a prefened antisense molecule is for a cancer sequences in the Tables, or for a ligand or activator thereof.
  • Antisense or sense oligonucleotides comprise a fragment generally at least about 14 nucleotides, preferably from about 14-30 nucleotides.
  • the ability to derive an antisense or a sense oligonucleotide, based upon a cDNA sequence encoding a given protein is described in, e.g., Stein and Cohen (1988) Cancer Res. 48:2659-2668; and van der Krol, et al. (1988) BioTechniques 6:958-976.
  • RNA interference is a mechanism to suppress gene expression in a sequence specific manner. See, e.g., Brumelkamp, et al.
  • RNAi double stranded small interfering RNAs
  • Ribozymes In addition to antisense polynucleotides, ribozymes can be used to target and inhibit transcription of cancer-associated nucleotide sequences.
  • a ribozyme is an RNA molecule that catalytically cleaves other RNA molecules.
  • Different kinds of ribozymes have been described, including group I ribozymes, hammerhead ribozymes, hai ⁇ in ribozymes, RNase P, and axhead ribozymes (see, e.g., Castanotto, et al. (1994) Adv. in Pharmacology 25: 289-317 for a general review of the properties of different ribozymes).
  • hai ⁇ in ribozymes are described, e.g., in Hampel, et al. (1990) Nucl. Acids Res. 18:299-304; European Patent Publication No. 0 360 257; U.S. Patent No. 5,254,678. Methods of preparation are described in, e.g., WO 94/26877; Ojwang, et al. (1993) Proc. Natl. Acad. Sci. USA 90:6340-6344; Yamada, et al. (1994) Human Gene Therapy 1:39- 45; Leavitt, et al.(1995) Proc. Natl. Acad. Sci. USA 92:699-703; Leavitt, et al. (1994) Human Gene Therapy 5:1151-120; and Yamada, et al. (1994) Virology 205: 121-126.
  • Polynucleotide modulators of cancer may be introduced into a cell containing the target nucleotide sequence by formation of a conjugate with a ligand binding molecule, as described in WO 91/04753.
  • Suitable ligand binding molecules include, but are not limited to, cell surface receptors, growth factors, other cytokines, or other ligands that bind to cell surface receptors.
  • conjugation of the ligand binding molecule does not substantially interfere with the ability of the ligand binding molecule to bind to its conesponding molecule or receptor, or block entry of the sense or antisense oligonucleotide or its conjugated version into the cell.
  • a polynucleotide modulator of cancer may be introduced into a cell containing the target nucleic acid sequence, e.g., by formation of an polynucleotide-lipid complex, as described in WO 90/10448. It is understood that the use of antisense molecules or knock out and knock in models may also be used in screening assays as discussed above, in addition to methods of treatment.
  • methods of modulating cancer in cells or organisms comprise administering to a cell an anti-cancer antibody that reduces or eliminates the biological activity of an endogenous cancer protein.
  • the methods comprise administering to a cell or organism a recombinant nucleic acid encoding a cancer protein. This may be accomplished in any number of ways. In a prefened embodiment, e.g., when the cancer sequence is down-regulated in cancer, such state may be reversed by increasing the amount of cancer gene product in the cell. This can be accomplished, e.g., by overexpressing the endogenous cancer gene or administering a gene encoding the cancer sequence, using known gene-therapy techniques.
  • the gene therapy techniques include the inco ⁇ oration of the exogenous gene using enhanced homologous recombination (EHR), e.g., as described in PCT/US93/0386.
  • EHR enhanced homologous recombination
  • the cancer sequence is up-regulated in cancer
  • the activity of the endogenous cancer gene is decreased, e.g., by the administration of a cancer antisense or other inhibitor, e.g., RNAi.
  • the cancer proteins of the present invention may be used to generate polyclonal and monoclonal antibodies to cancer proteins.
  • the cancer proteins can be coupled, using standard technology, to affinity chromatography columns. These columns may then be used to purify cancer antibodies useful for production, diagnostic, or therapeutic pu ⁇ oses.
  • the antibodies are generated to epitopes unique to a cancer protein; that is, the antibodies show little or no cross-reactivity to other proteins.
  • the cancer antibodies may be coupled to standard affinity chromatography columns and used to purify cancer proteins.
  • the antibodies may also be used as blocking polypeptides, as outlined above, since they will specifically bind to the cancer protein.
  • the invention provides methods for identifying cells containing variant cancer genes, e.g., determining all or part of the sequence of at least one endogenous cancer gene in a cell.
  • the invention provides methods of identifying the cancer genotype of an individual, e.g., determining all or part of the sequence of at least one cancer gene of the individual. This is generally done in at least one tissue of the individual, and may include the evaluation of a number of tissues or different samples of the same tissue.
  • the method may include comparing the sequence of the sequenced cancer gene to a known cancer gene, e.g., a wild-type gene.
  • the sequence of all or part of the cancer gene can then be compared to the sequence of a known cancer gene to determine if any differences exist. This can be done using known homology programs, such as Bestfit, etc.
  • known homology programs such as Bestfit, etc.
  • the presence of a difference in the sequence between the cancer gene of the patient and the known cancer gene conelates with a disease state or a propensity for a disease state, as outlined herein.
  • the cancer genes are used as probes to determine the number of copies of the cancer gene in the genome.
  • the cancer genes are used as probes to determine the chromosomal localization of the cancer genes.
  • Information such as chromosomal localization finds use in providing a diagnosis or prognosis in particular when chromosomal abnormalities such as translocations, and the like are identified in the cancer gene locus.
  • a therapeutically effective dose of a cancer protein or modulator thereof is administered to a patient.
  • therapeutically effective dose herein is meant a dose that produces effects for which it is administered. The exact dose will depend on the pu ⁇ ose of the treatment, and will be ascertainable using known techniques. See, e.g., Ansel, et al. (1999) Pharmaceutical Dosage Forms and Drug Delivery Lippincott; Lieberman (1992) Pharmaceutical Dosage Forms (vols. 1-3) Dekker, ISBN 0824770846, 082476918X, 0824712692, 0824716981; Lloyd (1999) The Art, Science and Technology of Pharmaceutical Compounding Amer. Pharmaceut.
  • a "patient” for the pu ⁇ oses of the present invention includes both humans and other animals, particularly mammals. Thus the methods are applicable to both human therapy and veterinary applications.
  • the patient is a mammal, preferably a primate, and in the most prefened embodiment the patient is human.
  • the administration of the cancer proteins and modulators thereof of the present invention can be done in a variety of ways, including, but not limited to, orally, subcutaneously, intravenously, intranasally, transdermally, intraperitoneally, intramuscularly, intrapulmonary, vaginally, rectally, or intraocularly.
  • the cancer proteins and modulators may be directly applied as a solution or spray.
  • the pharmaceutical compositions of the present invention comprise a cancer protein in a form suitable for administration to a patient.
  • the pharmaceutical compositions are in a water soluble form, such as being present as pharmaceutically acceptable salts, which is meant to include both acid and base addition salts.
  • “Pharmaceutically acceptable acid addition salt” refers to those salts that retain the biological effectiveness of the free bases and that are not biologically or otherwise undesirable, formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like, and organic acids such as acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, and the like.
  • inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like
  • organic acids such as acetic acid, propionic acid, glycolic acid, pyruvic
  • “Pharmaceutically acceptable base addition salts” include those derived from inorganic bases such as sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts, and the like. Particularly prefened are the ammonium, potassium, sodium, calcium, and magnesium salts. Salts derived from pharmaceutically acceptable organic non-toxic bases include salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine.
  • compositions may also include one or more of the following: carrier proteins such as serum albumin; buffers; fillers such as microcrystalline cellulose, lactose, corn and other starches; binding agents; sweeteners and other flavoring agents; coloring agents; and polyethylene glycol.
  • compositions can be administered in a variety of unit dosage forms depending upon the method of administration.
  • unit dosage forms suitable for oral administration include, but are not limited to, powder, tablets, pills, capsules and lozenges.
  • cancer protein modulators e.g., antibodies, antisense constructs, ribozymes, small organic molecules, etc.
  • This is typically accomplished either by complexing the molecule(s) with a composition to render it resistant to acidic and enzymatic hydrolysis, or by packaging the molecule(s) in an appropriately resistant carrier, such as a liposome or a protection barrier. Means of protecting agents from digestion are available.
  • compositions for administration will commonly comprise a cancer protein modulator dissolved in a pharmaceutically acceptable carrier, preferably an aqueous carrier.
  • a pharmaceutically acceptable carrier preferably an aqueous carrier.
  • aqueous carriers can be used, e.g., buffered saline and the like. These solutions are sterile and generally free of undesirable matter.
  • These compositions maybe sterilized by conventional, well known sterilization techniques.
  • the compositions may contain pharmaceutically acceptable auxiliary substances as required to approximate physiological conditions such as pH adjusting and buffering agents, toxicity adjusting agents, and the like, e.g., sodium acetate, sodium chloride, potassium chloride, calcium chloride, sodium lactate, and the like.
  • concentration of active agent in these formulations can vary widely, and will be selected primarily based on fluid volumes, viscosities, body weight, and the like in accordance with the particular mode of administration selected and the patient's needs (e.g., (1980) Remington's Pharmaceutical Science (18th ed.) Mack, and Hardman and Limbird (eds. 2001) Goodman and Gilman: The Pharmacologial Basis of Therapeutics (10th ed.) McGraw-Hill.
  • a typical pharmaceutical composition for intravenous administration would be about 0.1 to 10 mg per patient per day.
  • compositions containing modulators of cancer proteins can be administered for therapeutic or prophylactic treatments.
  • compositions are administered to a patient suffering from a disease (e.g., a cancer) in an amount sufficient to cure or at least partially anest the disease and its complications.
  • a disease e.g., a cancer
  • a therapeutically effective dose An amount adequate to accomplish this is defined as a "therapeutically effective dose.” Amounts effective for this use will depend upon the severity of the disease and the general state of the patient's health. Single or multiple administrations of the compositions may be administered depending on the dosage and frequency as required and tolerated by the patient. In any event, the composition should provide a sufficient quantity of the agents of this invention to effectively treat the patient.
  • An amount of modulator that is capable of preventing or slowing the development of cancer in a mammal is refened to as a "prophylactically effective dose.” The particular dose required for a prophylactic treatment will depend upon the medical condition and history of the mammal, the particular cancer being prevented, as well as other factors such as age, weight, gender, administration route, efficiency, etc.
  • Such prophylactic treatments may be used, e.g., in a mammal who has previously had cancer to prevent a recunence of the cancer, or in a mammal who is suspected of having a significant likelihood of developing cancer based, at least in part, upon gene expression profiles.
  • Vaccine strategies may be used, in either a DNA vaccine form, or protein vaccine.
  • cancer protein-modulating compounds can be administered alone or in combination with additional cancer modulating compounds or with other therapeutic agent, e.g., other anti-cancer agents or treatments.
  • one or more nucleic acids e.g., polynucleotides comprising nucleic acid sequences set forth in the Tables, such as RNAi, antisense polynucleotides or ribozymes, will be introduced into cells, in vitro or in vivo.
  • the present invention provides methods, reagents, vectors, and cells useful for expression of cancer-associated polypeptides and nucleic acids using in vitro (cell-free), ex vivo or in vivo (cell or organism-based) recombinant expression systems.
  • the particular procedure used to introduce the nucleic acids into a host cell for expression of a protein or nucleic acid is application specific.
  • cancer proteins and modulators are administered as therapeutic agents, and can be formulated as outlined above.
  • cancer genes (including both the full-length sequence, partial sequences, or regulatory sequences of the cancer coding regions) can be administered in a gene therapy application. These cancer genes can include inhibitory applications, e.g., as inhibitory RNA, gene therapy (e.g., for inco ⁇ oration into the genome), or antisense compositions.
  • Cancer polypeptides and polynucleotides can also be administered as vaccine compositions to stimulate HTL, CTL, and antibody responses.
  • vaccine compositions can include, e.g., lipidated peptides (see, e.g.,Vitiello, et al. (1995) J. Clin. Invest. 95:341-349), peptide compositions encapsulated in poly(DL-lactide-co-glycolide) ("PLG”) microspheres (see, e.g., Eldridge, et al. (1991) Molec. Immunol. 28:287-294,; Alonso, et al. (1994) Vaccine 12:299-306; Jones, et al.
  • Vaccine 13:675-681 peptide compositions contained in immune stimulating complexes (ISCOMS) (see, e.g., Takahashi, et al. (1990) Nature 344:873- 875; Hu, et al. (1998) Clin Exp Immunol. 113:235-243), multiple antigen peptide systems (MAPs) (see, e.g., Tarn (1988) Proc. Natl. Acad. Sci. USA 85:5409-5413; Tarn (1996) Immunol.
  • ISCOMS immune stimulating complexes
  • MAPs multiple antigen peptide systems
  • Toxin-targeted delivery technologies also known as receptor mediated targeting, such as those of Avant Immunotherapeutics, Inc. (Needham, Massachusetts) may also be used.
  • Vaccine compositions often include adjuvants.
  • Many adjuvants contain a substance designed to protect the antigen from rapid catabolism, such as aluminum hydroxide or mineral oil, and a stimulator of immune responses, such as lipid A, Bortadella pertussis, or Mycobacterium tuberculosis derived proteins.
  • adjuvants are commercially available as, e.g., Freund's incomplete Adjuvant and Complete Adjuvant (Difco Laboratories, Detroit, MI); Merck Adjuvant 65 (Merck and Company, Inc., Rahway, NJ); AS-2 (SmithKline Beecham, Philadelphia, PA); aluminum salts such as aluminum hydroxide gel (alum) or aluminum phosphate; salts of calcium, iron, or zinc; an insoluble suspension of acylated tyrosine; acylated sugars; cationically or anionically derivatized polysaccharides; polyphosphazenes; biodegradable microspheres; monophosphoryl lipid A and quil A.
  • Cytokines such as GM-CSF, interleukin-2, -7, -12, and other like growth factors, may also be used as adjuvants.
  • Vaccines can be administered as nucleic acid compositions wherein DNA or RNA encoding one or more of the polypeptides, or a fragment thereof, is administered to a patient.
  • This approach is described, for instance, in Wolff et. al. (1990) Science 247:1465-1468, as well as U.S. Patent Nos. 5,580,859; 5,589,466; 5,804,566; 5,739,118; 5,736,524; 5,679,647; WO 98/04720; and in more detail below.
  • DNA-based delivery technologies include "naked DNA”, facilitated (bupivicaine, polymers, peptide-mediated) delivery, cationic lipid complexes, and particle-mediated (“gene gun”) or pressure-mediated delivery (see, e.g., U.S. Patent No. 5,922,687).
  • the peptides of the invention can be expressed by viral or bacterial vectors.
  • expression vectors include attenuated viral hosts, such as vaccinia or fowlpox. This approach involves the use of vaccinia virus, e.g., as a vector to express nucleotide sequences that encode cancer polypeptides or polypeptide fragments. Upon introduction into a host, the recombinant vaccinia virus expresses the immunogenic peptide, and thereby elicits an immune response.
  • Vaccinia vectors and methods useful in immunization protocols are described in, e.g., U.S. Patent No. 4,722,848.
  • BCG Bacille Calmette Guerin
  • BCG vectors are described in Stover, et al. (1991) Nature 351 :456-460.
  • a wide variety of other vectors are availablel for therapeutic administration or immunization, e.g., adeno and adeno-associated virus vectors, retroviral vectors, Salmonella typhi vectors, detoxified anthrax toxin vectors, and the like. See, e.g., Shata, et al. (2000) Mol Med Today 6:66-71; Shedlock, et al. (2000) J. Leukoc. Biol. 68:793- 806; Hipp, et al. (2000) In Vivo 14:571-85.
  • Methods for the use of genes as DNA vaccines are well known, and include placing a cancer gene or portion of a cancer gene under the control of a regulatable promoter or a tissue- specific promoter for expression in a cancer patient.
  • the cancer gene used for DNA vaccines can encode full-length cancer proteins, but more preferably encodes portions of the cancer proteins including peptides derived from the cancer protein.
  • a patient is immunized with a DNA vaccine comprising a plurality of nucleotide sequences derived from a cancer gene.
  • cancer-associated genes or sequence encoding sub fragments of a cancer protein are introduced into expression vectors and tested for their immunogenicity in the context of Class I MHC and an ability to generate cytotoxic T cell responses. This procedure provides for production of cytotoxic T cell responses against cells which present antigen, including intracellular epitopes.
  • DNA vaccines include a gene encoding an adjuvant molecule with the DNA vaccine.
  • adjuvant molecules include cytokines that increase the immunogenic response to the cancer polypeptide encoded by the DNA vaccine. Additional or alternative adjuvants are available.
  • cancer genes find use in generating animal models of cancer.
  • gene therapy technology e.g., wherein inhibitory or antisense RNA directed to the cancer gene will also diminish or repress expression of the gene.
  • Animal models of cancer find use in screening for modulators of a cancer-associated sequence or modulators of cancer.
  • transgenic animal technology including gene knockout technology, e.g., as a result of homologous recombination with an appropriate gene targeting vector, will result in the absence or increased expression of the cancer protein.
  • tissue-specific expression or knockout of the cancer protein may be necessary.
  • the cancer protein is overexpressed in cancer.
  • transgenic animals can be generated that overexpress the cancer protein.
  • promoters of various strengths can be employed to express the transgene.
  • the number of copies of the integrated transgene can be determined and compared for a determination of the expression level of the transgene. Animals generated by such methods will find use as animal models of cancer and are additionally useful in screening for modulators to treat cancer. Kits for Use in Diagnostic and/or Prognostic Applications
  • kits are also provided by the invention.
  • such kits may include at least one of the following: assay reagents, buffers, cancer-specific nucleic acids or antibodies, hybridization probes and/or primers, antisense polynucleotides, ribozymes, dominant negative cancer polypeptides or polynucleotides, small molecule inhibitors of cancer-associated sequences etc.
  • a therapeutic product may include sterile saline or another pharmaceutically acceptable emulsion and suspension base.
  • the kits may include instructional materials containing instructions (e.g., protocols) for the practice of the methods of this invention. While the instructional materials typically comprise written or printed materials, they are not limited to such.
  • a medium capable of storing such instructions and communicating them to an end user is contemplated by this invention.
  • Such media include, but are not limited to, electronic storage media (e.g., magnetic discs, tapes, cartridges, chips), optical media (e.g., CD ROM), and the like.
  • Such media may include addresses to internet sites that provide such instructional materials.
  • kits for screening for modulators of cancer- associated sequences can be prepared from readily available materials and reagents.
  • such kits can comprise one or more of the following materials: a cancer-associated polypeptide or polynucleotide, reaction tubes, and instructions for testing cancer-associated activity.
  • the kit contains biologically active cancer protein.
  • kits and components can be prepared according to the present invention, depending upon the intended user of the kit and the particular needs of the user. Diagnosis would typically involve evaluation of a plurality of genes or products. The genes will typically be selected based on conelations with important parameters in disease which may be identified in historical or outcome data.
  • Table 1 lists medical conditions, abnormalities, or organs affected by disease, referred to in Tables 2A 68, for which markers have been identified, and other related medical conditions (including va ⁇ ous stages and/or metastases) in which those markers will also be useful, e g , in therapeutic, diagnostic, prognostic, subsetti ⁇ g vaccine, and other uses blood vessels/angiogenesis hemangiomas, lymphangiomas, wound healing, tissue remodeling, pso ⁇ asis, ischemic, heart disease, inflammatory diseases (e g , arth ⁇ tis, asthma, chronic bronchitis), atherosclerosis, endometriosis, presumed ocular histoplasmosis syndrome, hypoxia, solid tumors, lymphomas, autoimmune diseases (e g , RA, SLE, juvenile chronic arth ⁇ tis, pigmented villonodular synovitis, etc ), retinal neovascula ⁇ zation syndromes (e g , diabetic retinopathy, ma
  • emphysema chronic bronchitis
  • asthma bronchiectasis
  • cirrhosis liver fibrosis
  • renal fibrosis scleroderma
  • wound healing head and neck tumors of the nasal cavity paranasal sinuses, nasopharynx, oral cavity, oral pharynx, lip, larynx, hypopharynx, salivary glands, paragangliomas, esophagus kidney clear cell ( ⁇ onpapillary) carcinoma, papillary carcinoma, chromophobe renal carcinoma, hypemephroma, adenocarcinoma, sporadic renal carcinomas, hereditary renal carcinomas (von Hippel-Lindau disease), carcinoma of the renal pelvis, ureteral carcinoma, fibroma, papillary adenoma, angiomyolipoma, oncocytoma leukocytes acute lymphoblastic leukemia/lymphoma, maf
  • Tables 2C-66C list genomic positioning for Pkeys lacking Unigene ID's and accession numbers in Tables 2A-66C, respectively For each predicted exon is listed genomic sequence source used for prediction Nucleotide locations of each predicted exon are also listed
  • Table 2A lists about 1031 genes up regulated in acute lymphocyte leukemia (ALL) compared to normal adult tissues These were selected from 35403 probesets on the ALL.
  • ALL acute lymphocyte leukemia
  • Affymet ⁇ x/Eos Hu01 GeneChip array such that the ratio of "average” leukemia to "average” normal adult tissues was greater than or equal to 1 7
  • the "average” leukemia level was set to the 75* percentile amongst various ALL samples
  • the "average” normal adult tissue level was set to the 85* percentile amongst various non malignant tissues
  • the 75 th percentile value amongst va ⁇ ous non malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated

Abstract

Described herein are genes whose expression are up-regulated or down-regulated in specific cancers. Related methods and compositions that can be used for diagnosis and treatment of those cancers are disclosed. Also described herein are methods that can be used to identify modulators of selected cancers.

Description

METHODS OF DIAGNOSIS OF CANCER, COMPOSITIONS AND METHODS OF SCREENING FOR MODULATORS OF CANCER CROSS-REFERENCES TO RELATED APPLICATIONS
This application claims priority to USSN 60/323,469, filed Setember 17, 2001; USSN 60/355,145, filed February 8, 2002; USSN 60/369,899, filed April 4, 2002; USSN 60/323,887, filed September 20, 2001; USSN 60/355,257, filed February 8, 2002; USSN 60/325,114, filed September 25, 2001; USSN 60/340,944, filed October 29, 2001; USSN 60/350,666, filed November 13, 2001; and USSN 60/372,246, filed April 12, 2002; each of which is incorporated herein by reference for all purposes.
FIELD OF THE INVENTION The invention relates to the identification of nucleic acid and protein expression profiles and nucleic acids, products, and antibodies thereto that are involved in cancer; and to the use of such expression profiles and compositions in the diagnosis, prognosis, and therapy of cancer. The invention further relates to methods for identifying and using agents and/or targets that modulate cancer.
BACKGROUND OF THE INVENTION Cancer is a major cause of morbidity in the United States. For example, in 1996, the American Cancer Society estimated that 1,359,150 people were diagnosed with a malignant neoplasm and 554,740 died from one of these diseases. Cancer is responsible for 23.9 percent of all American deaths and is exceeded only by heart disease as a cause of mortality (33 percent). Unfortunately, cancer mortality is increasing and sometime early in this century, cancer is expected to become the leading cause of mortality in the United States as it already is in Japan.
Cancers share the charactaristic of disordered control over normal cell division, growth, and differentiation. Their initial clinical manifestations are extremely heterogeneous, with over 70 types of cancer arising in virtually every organ and tissue of the body. Moreover, some of those similarly classified cancer types may represent multiple different molecular diseases. Unfortunately, some cancers may be virtually asymptomatic until late in the disease course, when treatment is more difficult, and prognosis grim. Treatment for cancer typically includes surgery, chemotherapy, and/or radiation therapy. Although nearly 50 percent of cancer patients can be effectively treated using these methods, the current therapies all induce serious side effects which diminish quality of life. The identification of novel therapeutic targets and diagnostic markers will be important for improving the diagnosis and treatment of cancer patients.
Recent advances in molecular medicine have increased the interest in tumor-specific antigens that could serve as targets for various immunotherapeutic or small molecule strategies. Antigens suitable for immunotherapeutic strategies should be highly expressed in cancer tissues, preferably accessible from the vasculature and at the cell surface, and ideally not expressed in normal adult tissues. Expression in tissues that are dispensable for life, however, may be tolerated, e.g., reproductive organs. Examples of antigens that are currently available for the detection and treatment of certain cancers include Her2/neu and the B-cell antigen CD20. Humanized monclonal antibodies directed to Her2/neu (Herceptin®/trastuzumab) are currently in use for the treatment of metastatic breast cancer. See Ross and Fletcher (1998) Stem Cells 16:413-428. Similarly, anti-CD20 monoclonal antibodies (Rituxin®/rituximab) are used to effectively treat non-Hodgkin's lymphoma. See Maloney, et al. (1997) Blood 90:2188-2195; Leget and Czuczman (1998) Curr. Opin. Oncol. 10:548-551.
The elucidation of a role for novel proteins and compounds in disease states for identification of therapeutic targets and diagnostic markers is valuable for improving the current treatment of cancer patients. Accordingly, provided herein are molecular targets for therapeutic intervention in various defined cancers. Additionally, provided herein are methods that can be used in diagnosis and prognosis of cancer. Further provided are methods that can be used to screen candidate bioactive agents for the ability to modulate cancer.
SUMMARY OF THE INVENTION The present invention provides methods for determining the presence or absence of a pathological cell in a patient, the method comprising detecting a nucleic acid comprising a sequence at least 80% identical to a sequence as described in Tables 2 A-68 in a biological sample from the patient, thereby determining the presence or absence of the pathological cell. In certain embodiments of the method, the pathology is described in Table 1, including a cancer; the biological sample comprises isolated nucleic acids; the nucleic acids are mRNA; the biological sample is tissue from an organ which is affected by the pathology of Table 1, including a cancer; a further step is used of amplifying nucleic acids before the step of detecting the nucleic acid; the detecting is of a protein encoded by the nucleic acid; the nucleic acid comprises a sequence as described in Tables 2A-68; the detecting step is carried out by using a labeled nucleic acid probe, utilizing a biochip comprising at sequence at least 80% identical to a sequence as described in Tables 2A-68, or detecting a polypeptide encoded by the nucleic acid; or the patient is undergoing a therapeutic regimen to treat the pathology of Table 1 , or is suspected of having the pathology or cancer.
Compostions are also provided, e.g., an isolated nucleic acid molecule comprising a sequence as described in Tables 2A-68, including, e.g., those which are labeled; an expression vector comprising such nucleic acid; a host cell comprising such expression vector; an isolated polypeptide which is encoded by such a nucleic acid molecule comprising a sequence as described in Tables 2A-68; or an antibody that specifically binds the polypeptide. In particular embodiments, the antibody is: conjugated to an effector component, is conjugated to a detectable label (including, e.g., a fluorescent label, a radioisotope, or a cytotoxic chemical), an antibody fragment, or is a humanized antibody. Additional methods are provided, including methods for specifically targeting a compound to a pathological cell in a patient, the method comprising administering to the patient an antibody, as described, thereby providing the targetting. Others include, e.g., methods for determining the presence or absence of a pathological cell in a patient, the methods comprising contacting a biological sample with an antibody, as described. In more particular methods, the antibody is: conjugated to an effector component, or to a fluorescent label; or the biological sample is a blood, serum, urine, or stool sample.
Further methods include those for identifying a compound that modulates a pathology- associated polypeptide, the method comprising steps of: contacting the compound with a pathology-associated polypeptide, the polypeptide encoded by a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as described in Tables 2A-68; and determining the functional effect of the compound upon the polypeptide. Another drug screening assay method comprises steps of: administering a test compound to a mammal having a pathology of Table 1 or a cell isolated therefrom; and comparing the level of gene expression of a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as described in Tables 2A-68 in a treated cell or mammal with the level of gene expression of the polynucleotide in a control cell or mammal, wherein a test compound that modulates the level of expression of the polynucleotide is a candidate for the treatment of the pathology. DETAILED DESCRIPTION OF THE INVENTION In accordance with the objects outlined above, the present invention provides novel methods for diagnosis and prognosis evaluation for various disorders, e.g., angiogenesis, fibrosis, and various defined forms of cancer, including metastatic cancer, as well as methods for screening for compositions which modulate such conditions. Also provided are methods for treating such disorders or cancers. See, e.g., American Society of Clinical Oncology (ed. 2001) ASCO Curriculum: Symptom Management Kendall/Hunt, ISBN: 0787277851; Bonadonna, et al. (2001) Textbook of Breast Cancer (2d ed.) Dunitz Martin, ISBN: 1853178241; Devita and Hellman (eds. 2001) Cancer Principles and Practice of Oncology (2 vols.), Lippincott Williams, ISBN: 0781723876; Howell, et al. (2001) Breast Cancer Isis Medical Media, ISBN:
1901865584; Kaye and Laws (2001) Brain Tumours: An Encyclopedic Approach (2d ed.) Churchill Livingstone, ISBN: 0443064261; Mihm, et al. (2001) The Melanocytic Proliferation: A Comprehensive Textbook of Pigmented Lesions Wiley-Liss, ISBN: 0471252719; Montgomery and Aaron (2001) Clinical Pathology of Soft-Tissue Tumors Marcel Dekker, ISBN: 0824702905; Petrovich, et al. (eds. 2001) Combined Modality of Central Nervous System Tumors (Medical Radiology) Springer Verlag, ISBN: 3540660534; Rosen (2001) Rosen's Breast Pathology Lippincott Williams and Wilkins, ISBN: 0781723795; Shah, et al. (2001) Oral Cancer Isis Medical Media, ISBN: 189906687X; Weiss and Goldblum (2001) Enzinger and Weiss's Soft Tissue Tumors (4th ed.) Mosby, ISBN: 0323012000; Abeloff, et al. (eds. 2000) Clinical Oncology (2d ed.) Churchill Livingstone, ISBN: 044307545X; American Society of Clinical Oncology (ed. 2000) Cancer Genetics and Cancer Predisposition Testing Kendall Hunt, ISBN: 0787276154; Fletcher (2000) Diagnostic Histopathology of Tumors (2 vols. 2d ed.) Churchill Livingstone, ISBN: 0443079927; Vogelzang (ed. 2000) Comprehensive Textbook of Genitourinary Oncology (2d ed.) Lippincott Williams and Wilkins, ISBN: 0683306456; Holland, et al. (eds. 2000) HoUand-Frei Cancer Medicine (Book with CD-ROM 5th ed.) Decker, ISBN: 1550091131; Turrisi, et al. (2000) Lung Cancer Isis Medical Media, ISBN: 1901865428; Bartolozzi and Lencioni (eds. 1999) Liver Malignancies: Diagnostic and Interventional Radiology (Medical Radiology) Springer Verlag, ISBN: 3540647562; Gasparini (ed. 1999) Prognostic Variables in Node-Negative and Node-Positive Breast Cancer Kluwer, ISBN: 0792384474; Hansen (ed. 1999) The LASLC Textbook of Lung Cancer: International Association for the Study of Lung Cancer Dunitz Martin, ISBN: 1853177083; Raghavan, et al. (eds. 1999) Textbook of Uncommon Cancer (2nd ed.) Wiley, ISBN: 0471929212; Thawley, et al. (eds. 1999) Comprehensive Management of Head and Neck Tumors (2 vols.) Saunders, ISBN: 0721655823; Whittaker and Holmes (eds. 1999) Leukemia and Related Disorders (3d ed.) Blackwell Science, ISBN: 0865426074; Aapro (ed. 1998) OncoMedia: Medical Oncology (CD-ROM) Elsevier Science, ISBN: 0080427480; Abeloff (1998) Clinical Oncology (Library Version 2 CD-ROM Individual Version 2.0 Windows and Macintosh) Harcourt Brace, ISBN: 0443075557; Benson (ed. 1998) Gastrointestinal Oncology (Cancer Treatment and Research, CTAR 98) Kluwer, ISBN: 0792382056; Brambilla and Brambilla (eds. 1998) Lung Tumors: Fundamental Biology and Clinical Management (Vol 124) Marcel Dekker, ISBN: 0824701607; Canellos, et al. (eds. 1998) The Lymphomas Saunders, ISBN: 0721650309; Greenspan and Remagen (1998) Differential Diagnosis of Tumors and Tumor-Like Lesions of Bones and Joints Lippincott Williams and Wilkins Publishers, ISBN: 0397517106; Hiddemann (ed. 1998) Acute Leukemias VII: Experimental Approaches and Novel Therapies (Haematologie Und Bluttransfusion, Vol 39), Springer Verlag, ISBN: 3540635041; Husband and Reznek (1998) Imaging in Oncology (2 vols.) Mosby, ISBN: 1899066489; Leibel and Phillips (eds. 1998) Textbook of Radiation Oncology Saunders, ISBN: 0721653367; Maloney and Miller (eds.
1998) Cutaneous Oncology: Pathophysiolo y, Diagnosis, and Management Blackwell Science, ISBN: 0865425175; Mittal, et al. (eds. 1998) Advances in Radiation Therapy Kluwe. ISBN: 0792399811; Oldham (ed. 1998) Principles of Cancer Biotherapy (3d ed.) Kluwer, ISBN: 0792335074; Ozols (ed. 1998) Gynecologic Oncology Kluwer, ISBN: 0792380703; Parkin, et al. (eds. 1998) Cancer Incidence in Five Continents (Iarc Scientific Publications, No 143) Oxford University Press, ISBN: 9283221435; Perez and Brady (eds. 1998) Principles and Practice of Radiation Oncology Lippincott Williams and Wilkins, ISBN: 0397584164; Black, et al. (eds. 1997) Cancer of the Nervous System Blackwell Science, ISBN: 0865423849; Bonadonna, et al. (1997) Textbook of Breast Cancer: A Clinical Guide to Therapy Blackwell Science, ISBN: 1853173487; Pollock (ed. 1997) Surgical Oncology Kluwer, ISBN:
0792399005; Sheaves, et al. (eds. 1997) Clinical Endocrine Oncology Blackwell Science, ISBN: 086542862X; Vahrson (1997) Radiation Oncology of Gynecological Cancers Springer Verlag, ISBN: 0387567682; Walterhouse and Cohn (eds. 1997) Diagnostic and Therapeutic Advances in Pediatric Oncology Kluwer, ISBN: 0792399781; Aisner (ed. 1996) Comprehensive Textbook of Thoracic Oncology Lippincott, Williams and Wilkins, ISBN: 0683000624;
Bertino, et al. (eds. 1996) Encyclopedia of Cancer (3 vols.) Academic, ISBN: 012093230X; Cavalli, et al. (1996) Textbook of Medical Oncology Dunitz Martin, ISBN: 1853172901; Peckham, et al. (eds. 1995) Oxford Textbook of Oncology (2- Vols.) Oxford University Press, ISBN: 0192616854; and Freireich and Kantarjian (eds. 1996) Molecular Genetics and Therapy of Leukemia (Cancer Treatment and Research, V. 84) -Kluwer, ISBN: 0792339126.
In particular, identification of markers selectively expressed on defined cancers allows for use of that expression in diagnostic, prognostic, or therapeutic methods. As such, the invention defines various compositions, e.g., nucleic acids, polypeptides, antibodies, and small molecule agonists/antagonists, which will be useful to selectively identify those markers. For example, therapeutic methods may take the form of protein therapeutics which use the marker expression for selective localization or modulation of function (for those markers which have a causative disease effect), for vaccines, identification of binding partners, or antagonism, e.g., using antisense or RNAi. The markers may be useful for molecular characterization of subsets of the diseases, e.g., as provided in Table 1, which subsets may actually require very different treatments. Moreover, the markers may also be important in related diseases to the specific disorders and cancers, e.g., which affect similar tissues in non-malignant diseases, or have similar mechanisms of induction/maintenance. Metastatic processes or characteristics may also be targeted. Diagnostic and prognostic uses are made available, e.g., to subset related but distinct diseases, or to determine treatment strategy. The detection methods may be based upon nucleic acid, e.g., PCR or hybridization techniques, or protein, e.g., ELISA, imaging, IHC, etc. The diagnosis may be qualitative or quantitative, and may detect increases or decreases in expression levels.
Tables 2B-66C provide unigene cluster identification numbers for the nucleotide sequence of genes that exhibit increased or decreased expression in cancer samples, particularly sequences involved in angiogenisis, prostate cancer (including androgen independent and taxol resistant prostate cancer), breast cancer, colorectal cancer, cervical cancer, bladder cancer, lung cancer, ovarian cancer, uterine cancer, glioblastoma, Ewing sarcoma, and lung fibrosis. Tables 2A-67 also provide an exemplar accession number that provides a nucleotide sequence that is part of the unigene cluster. Definitions
The term "cancer protein" or "cancer polynucleotide" or "cancer-associated transcript" refers to nucleic acid and polypeptide polymorphic variants, alleles, mutants, and interspecies homologues that: (1) have a nucleotide sequence that has greater than about 60% nucleotide sequence identity, 65%, 70%, 75%, 80%, 85%, 90%, preferably about 92%, 94%, 96%, 97%, 98%, or 99% or greater nucleotide sequence identity, preferably over a region of over a region of at least about 25, 50, 100, 200, 500, 1000, or more nucleotides, to a nucleotide sequence of or associated with a gene of Tables 1-68; (2) bind to antibodies, e.g., polyclonal antibodies, raised against an immunogen comprising an amino acid sequence encoded by a nucleotide sequence of or associated with a gene of Tables 1-68, and conservatively modified variants thereof; (3) specifically hybridize under stringent hybridization conditions to a nucleic acid sequence, or the complement thereof of Tables 1-68 and conservatively modified variants thereof; or (4) have an amino acid sequence that has greater than about 60% amino acid sequence identity, 65%, 70%, 75%, 80%, 85%, preferably 90%, 91%, 93%, 95%, 97%, 98%, or 99% or greater amino sequence identity, preferably over a region of over a region of at least about 25, 50, 100, 200, 500, 1000, or more amino acids, to an amino acid sequence encoded by a nucleotide sequence of or associated with a gene of Tables 1-68. A polynucleotide or polypeptide sequence is typically from a mammal including, but not limited to, primate, e.g., human; rodent, e.g., rat, mouse, hamster; cow, pig, horse, sheep, or other mammal. A "cancer polypeptide" and a "cancer polynucleotide," include both naturally occurring or recombinant forms.
A "full length" cancer protein or nucleic acid refers to a cancer polypeptide or polynucleotide sequence, or a variant thereof, that contains elements normally contained in one or more naturally occurring, wild type cancer polynucleotide or polypeptide sequences. The "full length" may be prior to, or after, various stages of post-translational processing or splicing, including alternative splicing.
"Biological sample" as used herein is a sample of biological tissue or fluid that contains nucleic acids or polypeptides, e.g., of a cancer protein, polynucleotide, or transcript. Such samples include, but are not limited to, tissue isolated from primates, e.g., humans, or rodents, e.g., mice, and rats. Biological samples may also include sections of tissues such as biopsy and autopsy samples, frozen sections taken for histologic purposes, archival samples, blood, plasma, serum, sputum, stool, tears, mucus, hair, skin, etc. Biological samples also include explants and primary and/or transformed cell cultures derived from patient tissues. A biological sample is typically obtained from a eukaryotic organism, most preferably a mammal such as a primate e.g., chimpanzee or human; cow; dog; cat; a rodent, e.g., guinea pig, rat, mouse; rabbit; or a bird; reptile; or fish. Livestock and domestic animals are of interest.
"Providing a biological sample" means to obtain a biological sample for use in methods described in this invention. Most often, this will be done by removing a sample of cells from an animal, but can also be accomplished by using previously isolated cells (e.g., isolated by another person, at another time, and/or for another purpose), or by performing the methods of the invention in vivo. Archival tissues or materials, having treatment or outcome history, will be particularly useful. The terms "identical" or percent "identity," in the context of two or more nucleic acids or polypeptide sequences, refer to two or more sequences or subsequences that are the same or have a specified percentage of amino acid residues or nucleotides that are the same (e.g., about 70% identity, preferably 75%, 80%, 85%, 90%, 91%, 93%, 95%, 97%, 98%, 99%, or higher identity over a specified region, when compared and aligned for maximum correspondence over a comparison window or designated region) as measured using, e.g., a BLAST or BLAST 2.0 sequence comparison algorithms with default parameters described below, or by manual alignment and visual inspection (see, e.g., NCBI web site http://www.ncbi.nlm.nih.gov/BLAST/ or the like). Such sequences are then said to be "substantially identical." This definition also refers to, or may be applied to, the complement of a test sequence. The definition also includes sequences that have deletions and/or insertions, substitutions, and naturally occurring, e.g., polymorphic or allelic variants, and man-made variants. As described below, the preferred algorithms can account for gaps and the like. Preferably, identity exists over a region that is at least about 25 amino acids or nucleotides in length, or more preferably over a region that is 50- 100 amino acids or nucleotides in length. For sequence comparison, typically one sequence acts as a reference sequence, to which test sequences are compared. When using a sequence comparison algorithm, test and reference sequences are entered into a computer, subsequence coordinates are designated, if necessary, and sequence algorithm program parameters are designated. Preferably, default program parameters can be used, or alternative parameters can be designated. The sequence comparison algorithm then calculates the percent sequence identities for the test sequences relative to the reference sequence, based on the program parameters.
A "comparison window", as used herein, includes reference to a segment of contiguous positions selected from the group consisting typically of from 20 to 600, usually about 50 to about 200, more usually about 100 to about 150, in which a sequence may be compared to a reference sequence of the same number of contiguous positions after the two sequences are optimally aligned. Methods of alignment of sequences for comparison are well-known. Optimal alignment of sequences for comparison can be conducted, e.g., by the local homology algorithm of Smith and Waterman (1981) Adv. Appl. Math. 2:482-489, by the homology alignment algorithm of Needleman and Wunsch (1970) J. Mol. Biol. 48:443-453, by the search for similarity method of Pearson and Lipman (1988) Proc. Nat'l. Acad. Sci. USA 85:2444-2448, by computerized implementations of these algorithms (GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Genetics Computer Group, 575 Science Dr., Madison, WI), or by manual alignment and visual inspection (see, e.g., Ausubel, et al. (eds. 1995 and supplements) Current Protocols in Molecular Biology Wiley).
Preferred examples of algorithms that are suitable for determining percent sequence identity and sequence similarity include the BLAST and BLAST 2.0 algorithms, which are described in Altschul, et al. (1977) Nuc. Acids Res. 25:3389-3402 and Altschul, et al. (1990) Mol. Biol. 215:403-410. BLAST and BLAST 2.0 are used, with the parameters described herein, to determine percent sequence identity for the nucleic acids and proteins of the invention. Software for performing BLAST analyses is publicly available through the National Center for Biotechnology Information (http://www.ncbi.nlm.nih.gov/). This algorithm involves first identifying high scoring sequence pairs (HSPs) by identifying short words of length W in the query sequence, which either match or satisfy some positive-valued threshold score T when aligned with a word of the same length in a database sequence. T is referred to as the neighborhood word score threshold (Altschul, et al., supra). These initial neighborhood word hits act as seeds for initiating searches to find longer HSPs containing them. The word hits are extended in both directions along each sequence for as far as the cumulative alignment score can be increased.-Cumulative scores are calculated using, e.g., for nucleotide sequences, the parameters M (reward score for a pair of matching residues; always > 0) and N (penalty score for mismatching residues; always < 0). For amino acid sequences, a scoring matrix is used to calculate the cumulative score. Extension of the word hits in each direction are halted when: the cumulative alignment score falls off by the quantity X from its maximum achieved value; the cumulative score goes to zero or below, due to the accumulation of one or more negative- scoring residue alignments; or the end of either sequence is reached. The BLAST algorithm parameters W, T, and X determine the sensitivity and speed of the alignment. The BLASTN program (for nucleotide sequences) uses as defaults a wordlength (W) of 11, an expectation (E) of 10, M=5, N=-4 and a comparison of both strands. For amino acid sequences, the BLASTP program uses as defaults a wordlength of 3, and expectation (E) of 10, and the BLOSUM62 scoring matrix (see Henikoff and Henikoff (1992) Proc. Natl. Acad. Sci. USA 89:10915-919) alignments (B) of 50, expectation (E) of 10, M=5, N=-4, and a comparison of both strands.
The BLAST algorithm also performs a statistical analysis of the similarity between two sequences. See, e.g., Karlin and Altschul (1993) Proc. Nat'l. Acad. Sci. USA 90:5873-5787. One measure of similarity provided by the BLAST algorithm is the smallest sum probability (P(N)), which provides an indication of the probability by which a match between two nucleotide or amino acid sequences would occur by chance. For example, a nucleic acid is considered similar to a reference sequence if the smallest sum probability in a comparison of the test nucleic acid to the reference nucleic acid is less than about 0.2, more preferably less than about θ.01, and most preferably less than about 0.001. Log values may be negative large numbers, e.g., 5, 10, 20, 30, 40, 40, 70, 90, 110, 150, 170, etc.
An indication that two nucleic acid sequences are substantially identical is that the polypeptide encoded by the first nucleic acid is immunologically cross reactive with the antibodies raised against the polypeptide encoded by the second nucleic acid. Thus, a polypeptide is typically substantially identical to a second polypeptide, e.g., where the two peptides differ only by conservative substitutions. Another indication that two nucleic acid sequences are substantially identical is that the two molecules or their complements hybridize to each other under stringent conditions. Yet another indication that two nucleic acid sequences are substantially identical is that the same primers can be used to amplify the sequences. A "host cell" is a naturally occurring cell or a transformed cell that contains an expression vector and supports the replication or expression of the expression vector. Host cells may be cultured cells, explants, cells in vivo, and the like. Host cells may be prokaryotic cells such as E. coli, or eukaryotic cells such as yeast, insect, amphibian, or mammalian cells such as CHO, HeLa, and the like (see, e.g., the American Type Culture Collection catalog or web site, www.atcc.org).
The terms "isolated," "purified," or "biologically pure" refer to material that is substantially or essentially free from components that normally accompany it as found in its native state. Purity and homogeneity are typically determined using analytical chemistry techniques such as polyacrylamide gel electrophoresis or high performance liquid chromatography. A protein or nucleic acid that is the predominant species present in a preparation is substantially purified. In particular, an isolated nucleic acid is separated from some open reading frames that naturally flank the gene and encode proteins other than protein encoded by the gene. The term "purified" in some embodiments denotes that a nucleic acid or protein gives rise to essentially one band in an electrophoretic gel. Preferably, it means that the nucleic acid or protein is at least about 85% pure, more preferably at least 95% pure, and most preferably at least 99% pure. "Purify" or "purification" in other embodiments means removing at least one contaminant or component from the composition to be purified. In this sense, purification does not require that the purified compound be homogeneous, e.g., 100% pure. The terms "polypeptide," "peptide," and "protein" are used interchangeably herein to refer to a polymer of amino acid residues. The terms apply to amino acid polymers in which one or more amino acid residue is an artificial chemical mimetic of a corresponding naturally occurring amino acid, as well as to naturally occurring amino acid polymers, those containing modified residues, and non-naturally occurring amino acid polymers.
The term "amino acid" refers to naturally occurring and synthetic amino acids, as well as amino acid analogs and amino acid mimetics that function similarly to the naturally occurring amino acids. Naturally occurring amino acids are those encoded by the genetic code, as well as those amino acids that are later modified, e.g., hydroxyproline, γ-carboxyglutamate, and O- phosphoserine. Amino acid analogs refers to compounds that have the same basic chemical structure as a naturally occurring amino acid, e.g., an carbon that is bound to a hydrogen, a carboxyl group, an amino group, and an R group, e.g., homoserine, norleucine, methionine sulfoxide, methionine methyl sulfonium. Such analogs may have modified R groups (e.g., norleucine) or modified peptide backbones, but retain somebasic chemical structure as a naturally occurring amino acid. Amino acid mimetic refers to a chemical compound that has a structure that is different from the general chemical structure of an amino acid, but that functions similarly to another amino acid.
Amino acids may be referred to herein by either their commonly known three letter symbols or by the one-letter symbols recommended by the IUPAC-IUB Biochemical
Nomenclature Commission. Nucleotides, likewise, may be referred to by their commonly accepted single-letter codes.
"Conservatively modified variant" applies to both amino acid and nucleic acid sequences. With respect to particular nucleic acid sequences, conservatively modified variants refers to those nucleic acids which encode identical or essentially identical amino acid sequences, or where the nucleic acid does not encode an amino acid sequence, to essentially identical or associated, e.g., naturally contiguous, sequences. Because of the degeneracy of the genetic code, a large number of functionally identical nucleic acids encode most proteins. For instance, the codons GCA, GCC, GCG, and GCU each encode the amino acid alanine. Thus, at each position where an alanine is specified by a codon, the codon can be altered to another of the corresponding codons described without altering the encoded polypeptide. Such nucleic acid variations are "silent variations," which are one species of conservatively modified variations. Every nucleic acid sequence herein which encodes a polypeptide also describes silent variations of the nucleic acid. In certain contexts each codon in a nucleic acid (except AUG, which is ordinarily the only codon for methionine, and TGG, which is ordinarily the only codon for tryptophan) can be modified to yield a functionally similar molecule. Accordingly, a silent variation of a nucleic acid which encodes a polypeptide is implicit in a described sequence with respect to the expression product, but not necessarily with respect to actual probe sequences.
As to amino acid sequences, one of skill will recognize that individual substitutions, deletions, or additions to a nucleic acid, peptide, polypeptide, or protein sequence which alters, adds, or deletes a single amino acid or a small percentage of amino acids in the encoded sequence is a "conservatively modified variant" where the alteration results in the substitution of an amino acid with a chemically similar amino acid. Conservative substitution tables providing functionally similar amino acids are well known. Such conservatively modified variants are in addition to and do not exclude polymorphic variants, interspecies homologs, and alleles of the invention. Typically conservative substitutions include for one another: 1) Alanine (A), Glycine (G); 2) Aspartic acid (D), Glutamic acid (E); 3) Asparagine (N), Glutamine (Q); 4) Arginine (R), Lysine (K); 5) Isoleucine (I), Leucine (L), Methionine (M), Valine (V); 6) Phenylalanine (F), Tyrosine (Y), Tryptophan (W); 7) Serine (S), Threonine (T); and 8) Cysteine (C), Methionine (M) (see, e.g., Creighton (1984) Proteins: Structure and Molecular Properties Freeman).
Macromolecular structures such as polypeptide structures can be described in terms of various levels of organization. For a general discussion of this organization, see, e.g., Alberts, et al. (eds. 2001) Molecular Biology of the Cell (4th ed.) Garland; and Cantor and Schimmel (1980) Biophysical Chemistry Part I: The Conformation of Biological Macromolecules Freeman. "Primary structure" refers to the amino acid sequence of a particular peptide. "Secondary structure" refers to locally ordered, three dimensional structures within a polypeptide. These structures are commonly known as domains. Domains are portions of a polypeptide that often form a compact unit of the polypeptide and are typically 25 to approximately 500 amino acids long. Typical domains are made up of sections of lesser organization such as stretches of β-sheet and α-helices. "Tertiary structure" refers to the complete three dimensional structure of a polypeptide monomer. "Quaternary structure" refers to the three dimensional structure formed, usually by the noncovalent association of independent tertiary units. Ariisotropic terms are also known as energy terms.
"Nucleic acid" or "oligonucleotide" or "polynucleotide" or grammatical equivalents used herein means at least two nucleotides covalently linked together. Oligonucleotides are typically from about 5, 6, 7, 8, 9, 10, 12, 15, 25, 30, 40, 50, or more nucleotides in length, up to about 100 nucleotides in length. Nucleic acids and polynucleotides are a polymers of any length, including longer lengths, e.g., 200, 300, 500, 1000, 2000, 3000, 5000, 7000, 10,000, etc. A nucleic acid of the present invention will generally contain phosphodiester bonds, although in some cases, nucleic acid analogs are included that may have at least one different linkahge, e.g., phosphoramidate, phosphorothioate, phosphorodithioate, or O-methylphophoroamidite linkages (see Eckstein (1992) Oligonucleotides and Analogues: A Practical Approach Oxford Univ. Press); and peptide nucleic acid backbones and linkages. Other analog nucleic acids include those with positive backbones; non-ionic backbones, and non-ribose backbones, including those described in U.S. Patent Nos. 5,235,033 and 5,034,506, and Chapters 6 and 7 of Sanghvi and Cook (eds. 1994) Carbohydrate Modifications in Antisense Research ACS Symposium Series 580. Nucleic acids containing one or more carbocyclic sugars are also included within one definition of nucleic acids. Modifications of the ribose-phosphate backbone may be done for a variety of reasons, e.g., to increase the stability and half-life of such molecules in physiological environments or as probes on a biochip. Mixtures of naturally occurring nucleic acids and analogs can be made; alternatively, mixtures of different nucleic acid analogs, and mixtures of naturally occurring nucleic acids and analogs may be made.
A variety of references disclose such nucleic acid analogs, including, e.g., phosphoramidate (Beaucage, et al. (1993) Tetrahedron 49:1925-1963 and references therein; Letsinger (1970) J. Org. Chem. 35:3800-3803; Sprinzl, et al. (1977) Eur. J. Biochem. 81:579- 589; Letsinger, et al. (1986) Nucl. Acids Res. 14:3487-499; Sawai, et al. (1984) Chem. Lett. 805, Letsinger, et al. (1988) J. Am. Chem. Soc. 110:4470-4471; andPauwels, et al. (1986) Chemica Scripta 26:141-149), phosphorothioate (Mag, et al. (1991) Nucleic Acids Res. 19:1437-441; and U.S. Patent No. 5,644,048), phosphorodithioate (Brill, et al. (1989) J. Am. Chem. Soc. 111:2321-2322), O-methylphophoroamidite linkages (see Eckstein (1992) Oligonucleotides and Analogues: A Practical Approach, Oxford Univ. Press), and peptide nucleic acid backbones and linkages (see Egholm (1992) J. Am. Chem. Soc. 114:1895-1897; Meier, et al. (1992) Chem. Int. Ed. Engl. 31:1008-1010: Nielsen (1993) Nature 365:566-568; Carlsson, et al. (1996) Nature 380:207, all of which are incorporated by reference). Other analog nucleic acids include those with positive backbones (Denpcy, et al. (1995) Proc. Natl. Acad. Sci. USA 92:6097-101; non-ionic backbones (U.S. Patent Nos. 5,386,023, 5,637,684, 5,602,240, 5,216,141, and 4,469,863; Kiedrowski, et al. (1991) Angew. Chem. Intl. Ed. English 30:423-426; Letsinger, et al. (1988) J. Am. Chem. Soc. 110:4470-4471; Letsinger, et al. (1994) Nucleoside and Nucleotide 13:1597-xxx; Chapters 2 and 3 in Sanghvi and Cook (eds. 1994)
Carbohydrate Modifications in Antisense Research ACS Symposium Series 580; Mesmaeker, et al. (1994) Bioorganic and Medicinal Chem. Lett. 4:395-398; Jeffs, et al. (1994) J. Biomolecular NMR 34:17; Horn, et al. (1996) Tetrahedron Lett. 37:743-xxx) and non-ribose backbones, including those described in U.S. Patent Nos. 5,235,033 and 5,034,506, and Chapters 6 and 7 in Sanghvi and Cook (eds. 1994) Carbohydrate Modifications in Antisense Research ACS Symposium Series 580. Nucleic acids containing one or more carbocyclic sugars are also included within one definition of nucleic acids (see Jenkins, et al. (1995) Chem. Soc. Rev, pp 169-176). Several nucleic acid analogs are described in Rawls (page 35, June 2, 1997) C&E News. Particularly prefened are peptide nucleic acids (PNA) which includes peptide nucleic acid analogs. These backbones are substantially non-ionic under neutral conditions, in contrast to the highly charged phosphodiester backbone of naturally occurring nucleic acids. This results in at least two advantages. The PNA backbone exhibits improved hybridization kinetics. PNAs have larger changes in the melting temperature (Tm) for mismatched versus perfectly matched basepairs. DNA and RNA typically exhibit a 2-4° C drop in Tm for an internal mismatch. With the non-ionic PNA backbone, the drop is closer to 7-9° C. Similarly, due to their non-ionic nature, hybridization of the bases attached to these backbones is relatively insensitive to salt concentration. In addition, PNAs are not degraded by cellular enzymes, and thus can be more stable. The nucleic acids may be single stranded or double stranded, as specified, or contain portions of both double stranded or single stranded sequence. The depiction of a single strand also defines the sequence of the complementary strand; thus the sequences described herein also provide the complement of the sequence. The nucleic acid may be DNA, both genomic and cDNA, RNA, or a hybrid, where the nucleic acid may contain combinations of deoxyribo- and ribo-nucleotides, and combinations of bases, including uracil, adenine, thymine, cytosine, guanine, inosine, xanthine hypoxanthine, isocytosine, isoguanine, etc. "Transcript" typically refers to a naturally occurring RNA, e.g., a pre-mRNA, hnRNA, or mRNA. As used herein, the term "nucleoside" includes nucleotides and nucleoside and nucleotide analogs, and modified nucleosides such as amino modified nucleosides. In addition, "nucleoside" includes non- naturally occurring analog structures. Thus, e.g., the individual units of a peptide nucleic acid, each containing a base, are refened to herein as a nucleoside. A "label" or a "detectable moiety" is a composition detectable by spectroscopic, photochemical, biochemical, immunochemical, physiological, chemical, or other physical means. In general, labels fall into three classes: a) isotopic labels, which may be radioactive or heavy isotopes; b) immune labels, which may be antibodies, antigens, or epitope tags; and c) colored or fluorescent dyes. The labels may be incorporated into the cancer nucleic acids, proteins, and antibodies. For example, the label should be capable of producing, either directly or indirectly, a detectable signal. The detectable moiety may be a radioisotope, such as ^H, l^C, 32p5 35g5 or 125j5 electron-dense reagents, a fluorescent or chemiluminescent compound, such as fluorescein isothiocyanate, rhodamine, or luciferin, or an enzyme (e.g., as commonly used in an ELISA), biotin, digoxigenin, or haptens and proteins or other entities which can be made detectable such as alkaline phosphatase, beta-galactosidase, or horseradish peroxidase. Methods are known for conjugating the antibody to the label. See, e.g., Hunter, et al. (1962) Nature 144:945; David, et al. (1974) Biochemistry 13:1014-1021; Pain, et al. (1981) I Immunol. Meth. 40:219-230; and Nygren (1982) J. Histochem. and Cvtochem. 30:407-412.
An "effector" or "effector moiety" or "effector component" is a molecule that is bound (or linked, or conjugated), either covalently, through a linker or a chemical bond, or noncovalently, through ionic, van der Waals, electrostatic, or hydrogen bonds, to an antibody. The "effector" can be a variety of molecules including, e.g., detection moieties including radioactive compounds, fluorescent compounds, enzymes or substrates, tags such as epitope tags, toxins; activatable moieties, chemotherapeutic agents; lipases; antibiotics; or radioisotopes, e.g., emitting "hard" beta, radiation.
A "labeled nucleic acid probe or oligonucleotide" is one that is bound, e.g., covalently, through a linker or a chemical bond, or noncovalently, through ionic, van der Waals, electrostatic, or hydrogen bonds to a label such that the presence of the probe may be detected by detecting the presence of the label bound to the probe. Alternatively, methods using high affinity interactions may achieve the same results where one of a pair of binding partners binds to the other, e.g., biotin, streptavidin. As used herein a "nucleic acid probe or oligonucleotide" is a nucleic acid capable of binding to a target nucleic acid of complementary sequence through one or more types of chemical bonds, usually through complementary base pairing, e.g., through hydrogen bond formation. As used herein, a probe may include natural (e.g., A, G, C, or T) or modified bases (7-deazaguanosine, inosine, etc.). In addition, the bases in a probe may be joined by a linkage other than a phosphodiester bond, preferably one that does not functionally interfere with hybridization. Thus, e.g., probes may be peptide nucleic acids in which the constituent bases are joined by peptide bonds rather than phosphodiester linkages. Probes may bind target sequences lacking complete complementarity with the probe sequence depending upon the stringency of the hybridization conditions. The probes are preferably directly labeled, e.g., with isotopes, chromophores, lumiphores, chromogens, or indirectly labeled, e.g., with biotin to which a streptavidin complex may later bind. By assaying for the presence or absence of the probe, one can detect the presence or absence of the select sequence or subsequence. Diagnosis or prognosis may be based at the genomic level, or at the level of RNA or protein expression. The term "recombinant" when used with reference, e.g., to a cell, or nucleic acid, protein, or vector, indicates that the cell, nucleic acid, protein, or vector, has been modified by the introduction of a heterologous nucleic acid or protein or the alteration of a native nucleic acid or protein, or that the cell is derived from a cell so modified. Thus, e.g., recombinant cells express genes that are not found within the native (non-recombinant) form of the cell or express native genes that are otherwise abnormally expressed, under expressed, or not expressed at all. By the term "recombinant nucleic acid" herein is meant nucleic acid, originally formed in vitro, in general, by the manipulation of nucleic acid, e.g., using polymerases and endonucleases, in a form not noraially found in nature. In this manner, operably linkage of different sequences is achieved. Thus an isolated nucleic acid, in a linear form, or an expression vector formed in vitro by ligating DNA molecules that are not normally joined, are both considered recombinant for the purposes of this invention. It is understood that once a recombinant nucleic acid is made and reintroduced into a host cell or organism, it will replicate non-recombinantly, e.g., using the in vivo cellular machinery of the host cell rather than in vitro manipulations; however, such nucleic acids, once produced recombinantly, although subsequently replicated non- recombinantly, are still considered recombinant for the purposes of the invention.
Similarly, a "recombinant protein" is a protein made using recombinant techniques, e.g., through the expression of a recombinant nucleic acid as depicted above. A recombinant protein is distinguished from naturally occurring protein by at least one or more characteristics. The protein may be isolated or purified away from some or most of the proteins and compounds with which it is normally associated in its wild type host, and thus may be substantially pure. An isolated protein is unaccompanied by at least some of the material with which it is normally associated in its natural state, preferably constituting at least about 0.5%, more preferably at least about 5% by weight of the total protein in a given sample. A substantially pure protein comprises at least about 75% by weight of the total protein, with at least about 80% being prefened, and at least about 90% being particularly prefened. The definition includes the production of a skin cancer protein from one organism in a different organism or host cell. Alternatively, the protein may be made at a significantly higher concentration than is normally seen, through the use of an inducible promoter or high expression promoter, such that the protein is made at increased concentration levels. Alternatively, the protein may be in a form not normally found in nature, as in the addition of an epitope tag or amino acid substitutions, insertions and deletions, as discussed below.
The term "heterologous" when used with reference to portions of a nucleic acid indicates that the nucleic acid comprises two or more subsequences that are not normally found in the same relationship to each other in nature. For instance, the nucleic acid is typically recombinantly produced, having two or more sequences, e.g., from unrelated genes arranged to make a new functional nucleic acid, e.g., a promoter from one source and a coding region from another source. Similarly, a heterologous protein will often refer to two or more subsequences that are not found in the same relationship to each other in nature (e.g., a fusion protein). A "promoter" is typically an anay of nucleic acid control sequences that direct transcription of a nucleic acid. As used herein, a promoter includes necessary nucleic acid sequences near the start site of transcription, such as, in the case of a polymerase II type promoter, a TATA element. A promoter also optionally includes distal enhancer or repressor elements, which can be located as much as several thousand base pairs from the start site of transcription. A "constitutive" promoter is a promoter that is active under most environmental and developmental conditions. An "inducible" promoter is a promoter that is active under environmental or developmental regulation. The term "operably linked" refers to a functional linkage between a nucleic acid expression control sequence (such as a promoter, or anay of transcription factor binding sites) and a second nucleic acid sequence, e.g., wherein the expression control sequence directs transcription of the nucleic acid conesponding to the second sequence.
An "expression vector" is a nucleic acid construct, generated recombinantly or synthetically, with a series of specified nucleic acid elements that permit transcription of a particular nucleic acid in a host cell. The expression vector can be part of a plasmid, virus, or nucleic acid fragment. Typically, the expression vector includes a nucleic acid to be transcribed in operable linkage to a promoter.
The phrase "selectively (or specifically) hybridizes to" refers to the binding, duplexing, or hybridizing of a molecule selectively to a particular nucleotide sequence under stringent hybridization conditions when that sequence is present in a complex mixture (e.g., total cellular or library DNA or RNA). The phrase "stringent hybridization conditions" refers to conditions under which a probe will hybridize to its target subsequence, typically in a complex mixture of nucleic acids, but to no other sequences. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridize specifically at higher temperatures. An extensive guide to the hybridization of nucleic acids is found in "Overview of principles of hybridization and the strategy of nucleic acid assays" in Tijssen (1993) Hybridization with Nucleic Probes (Laboratory Techniques in Biochemistry and Molecular Biology) (vol. 24) Elsevier. Generally, stringent conditions are selected to be about 5-10° C lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength pH. The Tm is the temperature (under defined ionic strength, pH, and nucleic concentration) at which 50% of the probes complementary to the target hybridize to the target sequence at equilibrium (as the target sequences are present in excess, at Tm, 50% of the probes are occupied at equilibrium).
Stringent conditions will be those in which the salt concentration is less than about 1.0 M sodium ion, typically about 0.01-1.0 M sodium ion concentration (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30° C for short probes (e.g., about 10-50 nucleotides) and at least about 60° C for long probes (e.g., greater than about 50 nucleotides). Stringent conditions may also be achieved with the addition of destabilizing agents such as formamide. For selective or specific hybridization, a positive signal is typically at least two times background, preferably 10 times background hybridization. Exemplary stringent hybridization conditions can be as following: 50% formamide, 5x SSC, and 1% SDS, incubating at 42° C, or, 5x SSC, 1% SDS, incubating at 65° C, with wash in 0.2x SSC, and 0.1% SDS at 65° C. For PCR, a temperature of about 36° C is typical for low stringency amplification, although annealing temperatures may vary between about 32°-48° C depending on primer length. For high stringency PCR amplification, a temperature of about 62° C is typical, although high stringency annealing temperatures can range from about 50-65° C, depending on the primer length and specificity. Typical cycle conditions for both high and low stringency amplifications include a denaturation phase of 90-95° C for 30-120 sec, an annealing phase lasting 30-120 sec, and an extension phase of about 72° C for 1-2 min. Protocols and guidelines for low and high stringency amplification reactions are provided, e.g., in Innis, et al. (1990) PCR Protocols: A Guide to Methods and Applications, Academic Press, NY.
Nucleic acids that do not hybridize to each other under stringent conditions are still substantially identical if the polypeptides which they encode are substantially identical. This occurs, e.g., when a copy of a nucleic acid is created using the maximum codon degeneracy permitted by the genetic code. In such cases, the nucleic acids typically hybridize under moderately stringent hybridization conditions. Exemplary "moderately stringent hybridization conditions" include a hybridization in a buffer of 40% formamide, 1 M NaCl, 1% SDS at 37° C, and a wash in IX SSC at 45° C. A positive hybridization is typically at least twice background. Alternative hybridization and wash conditions can be utilized to provide conditions of similar stringency. Additional guidelines for determining hybridization parameters are provided in numerous references, e.g., Ausubel, et al. (eds. 1991 and supplements) Cunent Protocols in Molecular Biology Wiley.
The phrase "functional effects" in the context of assays for testing compounds that modulate activity of a cancer protein includes the determination of a parameter that is indirectly or directly under the influence of the cancer protein or nucleic acid, e.g., a physiological, functional, physical, or chemical effect, such as the ability to decrease cancer. It includes ligand binding activity; cell viability; cell growth on soft agar; anchorage dependence; contact inhibition and density limitation of growth; cellular proliferation; cellular transformation; growth factor or serum dependence; tumor specific marker levels; invasiveness into Matrigel; tumor growth and metastasis in vivo; mRNA and protein expression in cells undergoing metastasis; and other characteristics of cancer cells. "Functional effects" include in vitro, in vivo, and ex vivo activities.
By "determining the functional effect" is meant assaying for a compound that increases or decreases a parameter that is indirectly or directly under the influence of a cancer protein sequence, e.g., physiological, functional, enzymatic, physical, or chemical effects. Such functional effects can be measured, e.g., changes in spectroscopic characteristics (e.g., fluorescence, absorbance, refractive index), hydrodynamic (e.g., shape), chromatographic, or solubility properties for the protein, measuring inducible markers or transcriptional activation of the cancer protein, measuring binding activity or binding assays, e.g., binding to antibodies or other ligands, and measuring growth, cellular proliferation, cell viability, cellular transformation, growth factor or serum dependence, tumor specific marker levels, invasiveness into Matrigel, tumor growth and metastasis in vivo, mRNA and protein expression, and other characteristics of cancer cells. The functional effects can be evaluated by many means, e.g., microscopy for quantitative or qualitative measures of alterations in morphological features, measurement of changes in RNA or protein levels for cancer-associated sequences, measurement of RNA stability, identification of downstream or reporter gene expression (CAT, luciferase, -gal, GFP, and the like), e.g., via chemiluminescence, fluorescence, colorimetric reactions, antibody binding, inducible markers, and ligand binding assays.
"Inhibitors", "activators," and "modulators" of cancer polynucleotide and polypeptide sequences are used to refer to activating, inhibitory, or modulating molecules or compounds identified using in vitro and in vivo assays of cancer polynucleotide and polypeptide sequences. Inhibitors are compounds that, e.g., bind to, partially or totally block activity, decrease, prevent, delay activation, inactivate, desensitize, or down regulate the activity or expression of cancer proteins, e.g., antagonists. Antisense or inhibitory nucleic acids may seem to inhibit expression and subsequent function of the protein. "Activators" are compounds that increase, open, activate, facilitate, enhance activation, sensitize, agonize, or up regulate cancer protein activity. Inhibitors, activators, or modulators also include genetically modified versions of cancer proteins, e.g., versions with altered activity, as well as naturally occurring and synthetic ligands, antagonists, agonists, antibodies, small chemical molecules, and the like. Such assays for inhibitors and activators include, e.g., expressing the cancer protein in vitro, in cells, or cell membranes, applying putative modulator compounds, and then determining the functional effects on activity, as described above. Activators and inhibitors of cancer can also be identified by incubating cancer cells with the test compound and determining increases or decreases in the expression of 1 or more cancer proteins, e.g., 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 40, 50, or more cancer proteins, such as cancer proteins encoded by the sequences set out in Tables 1-68.
Samples or assays comprising cancer proteins that are treated with a potential activator, inhibitor, or modulator are compared to control samples without the inhibitor, activator, or modulator to examine the extent of inhibition. Control samples (untreated with inhibitors) are assigned a relative protein activity value of 100%. Inhibition of a polypeptide is achieved when the activity value relative to the control is about 80%, preferably 50%, more preferably 25-0%. Activation of a cancer polypeptide is achieved when the activity value relative to the control (untreated with activators) is 110%, more preferably 150%, more preferably 200-500% (e.g., two to five fold higher relative to the control), more preferably 1000-3000% higher.
The phrase "changes in cell growth" refers to any change in cell growth and proliferation characteristics in vitro or in vivo, such as cell viability, formation of foci, anchorage independence, semi-solid or soft agar growth, changes in contact inhibition and density limitation of growth, loss of growth factor or serum requirements, changes in cell morphology, gaining or losing immortalization, gaining or losing tumor specific markers, ability to form or suppress tumors when injected into suitable animal hosts, and/or immortalization of the cell. See, e.g., pp. 231-241 in Freshney (1994) Culture of Animal Cells a Manual of Basic Technique (2d ed.) Wiley-Liss. "Tumor cell" refers to precancerous, cancerous, and normal cells in a tumor.
"Cancer cells," "transformed" cells or "transformation" in tissue culture, refers to spontaneous or induced phenotypic changes that do not necessarily involve the uptake of new genetic material. Although transformation can arise from infection with a transforming virus and incorporation of new genomic DNA, or uptake of exogenous DNA, it can also arise spontaneously or following exposure to a carcinogen, thereby mutating an endogenous gene. Transformation is associated with phenotypic changes, such as immortalization of cells, abenant growth control, nonmorphological changes, and/or malignancy. See, Freshney (2000) Culture of Animal Cells: A Manual of Basic Technique (4th ed.) Wiley-Liss.
"Antibody" refers to a polypeptide comprising a framework region from an immunoglobulin gene or fragments thereof that specifically binds and recognizes an antigen.
The recognized immunoglobulin genes include the kappa, lambda, alpha, gamma, delta, epsilon, and mu constant region genes, as well as the myriad immunoglobulin variable region genes. Light chains are classified as either kappa or lambda. Heavy chains are classified as gamma, mu, alpha, delta, or epsilon, which in turn define the immunoglobulin classes, IgG, IgM, IgA, IgD, and IgE, respectively. Typically, the antigen-binding region of an antibody or its functional equivalent will be most critical in specificity and affinity of binding. See Paul (ed. 1999) Fundamental Immunology (4th ed.) Raven.
An exemplary immunoglobulin (antibody) structural unit comprises a tetramer. Each tetramer is composed of two identical pairs of polypeptide chains, each pair having one "light" (about 25 D) and one "heavy" chain (about 50-70 kD). The N-terminus of each chain defines a variable region of about 100 to 110 or more amino acids primarily responsible for antigen recognition. The terms variable light chain (Vjj and variable heavy chain (VJJ) refer to these light and heavy chains respectively.
Antibodies exist, e.g., as intact immunoglobulins or as a number of well-characterized fragments produced by digestion with various peptidases. Thus, e.g., pepsin digests an antibody below the disulfide linkages in the hinge region to produce F(ab)'2 a dimer of Fab which itself is a light chain joined to VJJ-CJJI by a disulfide bond. The F(ab)'2 may be reduced under mild conditions to break the disulfide linkage in the hinge region, thereby converting the F(ab)'2 dimer into an Fab' monomer. The Fab' monomer is essentially Fab with part of the hinge region (see Paul (ed. 1999) Fundamental Immunology (4th ed.) Raven. While various antibody fragments are defined in terms of the digestion of an intact antibody, one of skill will appreciate that such fragments may be synthesized de novo either chemically or by using recombinant DNA methodology. Thus, the term antibody, as used herein, also includes antibody fragments either produced by the modification of whole antibodies, or those synthesized de novo using recombinant DNA methodologies (e.g., single chain Fv) or those identified using phage display libraries (see, e.g., McCafferty, et al. (1990) Nature 348:552-554). For preparation of antibodies, e.g., recombinant, monoclonal, or polyclonal antibodies, many techniques known. See, e.g., Kohler and Milstein (1975) Nature 256:495-497; Kozbor, et al. (1983) Immunology Today 4:72; Cole, et al. (1985) pp. 77-96 in Reisfeld and Sell (1985) Monoclonal Antibodies and Cancer Therapy Liss; Coligan (1991) Cunent Protocols in Immunology Lippincott; Harlow and Lane (1988) Antibodies: A Laboratory Manual CSH Press; and Goding (1986) Monoclonal Antibodies: Principles and Practice (2d ed.) Academic
Press. Techniques for the production of single chain antibodies (U.S. Patent 4,946,778) can be adapted to produce antibodies to polypeptides of this invention. Also, transgenic mice, or other organisms such as other mammals, may be used to express humanized antibodies. Alternatively, phage display technology can be used to identify antibodies and heteromeric Fab fragments that specifically bind to selected antigens. See, e.g., McCafferty, et al. (1990) Nature 348:552-554; Marks, et al. (1992) Biotechnology 10:779-783. A "chimeric antibody" is an antibody molecule in which (a) the constant region, or a portion thereof, is altered, replaced, or exchanged so that the antigen binding site (variable region) is linked to a constant region of a different or altered class, effector function, and/or species, or an entirely different molecule which confers new properties to the chimeric antibody, e.g., an enzyme, toxin, hormone, growth factor, drug, etc.; or (b) the variable region, or a portion thereof, is altered, replaced, or exchanged with a variable region having a different or altered antigen specificity. Identification of cancer-associated sequences
In one aspect, the expression levels of genes are determined in different patient samples for which diagnosis information is desired, to provide expression profiles. An expression profile of a particular sample is essentially a "fingerprint" of the state of the sample; while two states may have any particular gene similarly expressed, the evaluation of a number of genes simultaneously allows the generation of a gene expression profile that is characteristic of the state of the cell. That is, normal tissue may be distinguished from cancerous or metastatic cancerous tissue, or cancer tissue or metastatic cancerous tissue can be compared with tissue from surviving cancer patients. By comparing expression profiles of tissue in known different cancer states, information regarding which genes are important (including both up-and down- regulation of genes) in each of these states is obtained. Molecular profiling may distinguish subtypes of a cunently collective disease designation, e.g., different forms of a cancer.
The identification of sequences that are differentially expressed in cancer versus non- cancer tissue allows the use of this information in a number of ways. For example, a particular treatment regime may be evaluated: does a chemotherapeutic drug act to down-regulate cancer, and thus tumor growth or recunence, in a particular patient. Alternatively, a treatment step may induce other markers which may be used as targets to destroy tumor cells. Similarly, diagnosis and treatment outcomes may be done or confirmed by comparing patient samples with the known expression profiles. Maliganant disease may be compared to non-malignant conditions. Metastatic tissue can also be analyzed to determine the stage of cancer in the tissue, or origin of primary tumor, e.g., metastasis from a remote primary site. Furthermore, these gene expression profiles (or individual genes) allow screening of drug candidates with an eye to mimicking or altering a particular expression profile; e.g., screening can be done for drugs that suppress the cancer expression profile. This may be done by making biochips comprising sets of the important cancer genes, which can then be used in these screens. These methods can also be done on the protein basis; that is, protein expression levels of the cancer proteins can be evaluated for diagnostic purposes or to screen candidate agents. In addition, the cancer nucleic acid sequences can be administered for gene therapy purposes, including the administration of antisense nucleic acids, or the cancer proteins (including antibodies and other modulators thereof) administered as therapeutic drugs. Thus the present invention provides nucleic acid and protein sequences that are differentially expressed in cancer relative to normal tissues and/or non-malignant disease, or in different types of related diseases, herein termed "cancer sequences." As outlined below, cancer sequences include those that are up-regulated (e.g., expressed at a higher level) in cancer, as well as those that are down-regulated (e.g., expressed at a lower level). In a prefened embodiment, the cancer sequences are from humans; however, cancer sequences from other organisms may be useful in animal models of disease and drug evaluation; thus, other cancer sequences are provided, from vertebrates, including mammals, including rodents (rats, mice, hamsters, guinea pigs, etc.), primates, farm animals (including sheep, goats, pigs, cows, horses, etc.) and pets (e.g., dogs, cats, etc.). Cancer sequences from other organisms may be obtained using the techniques outlined below.
Cancer sequences can include both nucleic acid and amino acid sequences. In a prefened embodiment, the skin cancer sequences are recombinant nucleic acids. These nucleic acid sequences are useful in a variety of applications, including diagnostic applications, which will detect naturally occurring nucleic acids, as well as screening applications; e.g., biochips comprising nucleic acid probes or PCR microtiter plates with selected probes to the cancer sequences.
A cancer sequence can be initially identified by substantial nucleic acid and/or amino acid sequence homology to the cancer sequences outlined herein. Such homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, e.g., using homology programs or hybridization conditions.
For identifying cancer-associated sequences, the cancer screen typically includes comparing genes identified in different tissues, e.g., normal and cancerous tissues, cancer and non-malignant conditions, non-malignant conditions and normal tissues, or tumor tissue samples from patients who have metastatic disease vs. non metastatic tissue. Other suitable tissue comparisons include comparing cancer samples with metastatic cancer samples from other cancers, such as lung, stomach, gastrointestinal cancers, etc. Samples of different stages of cancer, e.g., survivor tissue, drug resistant states, and tissue undergoing metastasis, are applied to biochips comprising nucleic acid probes. The samples are first microdissected, if applicable, and treated for preparation of mRNA. Suitable biochips are commercially available, e.g., from Affymetrix, Santa Clara, CA. Gene expression profiles as described herein are generated and the data analyzed. In one embodiment, the genes showing changes in expression as between normal and disease states are compared to genes expressed in other normal tissues, including, and not limited to lung, heart, brain, liver, stomach, kidney, muscle, colon, small intestine, large intestine, spleen, bone, and/or placenta. In a prefened embodiment, those genes identified during the cancer screen that are expressed in a significant amount in other tissues (e.g., essential organs) are removed from the profile, although in some embodiments, this is not necessary (e.g., where organs may be dispensible, e.g., female or male specific). That is, when screening for drugs, it is usually preferable that the target expression be disease specific, to minimize possible side effects on other organs were there expression.
In a prefened embodiment, cancer sequences are those that are up-regulated in cancer; that is, the expression of these genes is higher in the cancer tissue as compared to non-cancer or non-malignant tissue. "Up-regulation" as used herein often means at least about a two-fold change, preferably at least about a three fold change, with at least about five-fold or higher being prefened. Another embodiment is directed to sequences up-regulated in non-malignant conditions relative to normal. Uniformity among relevant samples is also prefened. Unigene cluster identification numbers and accession numbers herein are for the
GenBank sequence database and the sequences of the accession numbers are hereby expressly incorporated by reference. GenBank is available, see, e.g., Benson, et al. (1998) Nuc. Acids Res. 26:1-7; and http://www.ncbi.nlm.nih.gov/. Sequences are also available in other databases, e.g., European Molecular Biology Laboratory (EMBL) and DNA Database of Japan (DDBJ). In some situations, the sequences may be derived from assembly of available sequences or be predicted from genomic DNA using exon prediction algorithms, such as FGENESH. See Salamov and Solovyev (2000) Genome Res. 10:516-522. In other situations, sequences have been derived from cloning and sequencing of isolated nucleic acids.
In another prefened embodiment, cancer sequences are those that are down-regulated in the cancer; that is, the expression of these genes is lower in cancer tissue as compared to non- cancerous tissue. "Down-regulation" as used herein often means at least about a two-fold change, preferably at least about a three fold change, with at least about five-fold or higher being prefened. Informatics
The ability to identify genes that are over or under expressed in cancer can additionally provide high-resolution, high-sensitivity datasets which can be used in the areas of diagnostics, therapeutics, drug development, pharmacogenetics, protein structure, biosensor development, and other related areas. For example, the expression profiles can be used in diagnostic or prognostic evaluation of patients with cancer or related diseases. See Tables 1 and 3. Or as another example, subcellular toxicological information can be generated to better direct drug structure and activity conelation (see Anderson (June 11-12, 1998) Pharmaceutical Proteomics: Targets, Mechanism, and Function, paper presented at the IBC Proteomics conference, Coronado, CA). Subcellular toxicological information can also be utilized in a biological sensor device to predict the likely toxicological effect of chemical exposures and likely tolerable exposure thresholds (see U.S. Patent No. 5,811,231). Similar advantages accrue from datasets relevant to other biomolecules and bioactive agents (e.g., nucleic acids, saccharides, lipids, drugs, and the like).
Thus, in another embodiment, the present invention provides a database that includes at least one set of assay data. The data contained in the database is acquired, e.g., using anay analysis either singly or in a library format. The database can be in a form in which data can be maintained and transmitted, but is preferably an electronic database. The electronic database of the invention can be maintained on any electronic device allowing for the storage of and access to the database, such as a personal computer, but is preferably distributed on a wide area network, such as the World Wide Web.
The focus of the present section on databases that include peptide sequence data is for clarity of illustration only. Similar databases can be assembled for assay data acquired using an assay of the invention. The compositions and methods for identifying and/or quantitating the relative and/or absolute abundance of a variety of molecular and macromolecular species from a biological sample representing cancer, e.g., the identification of cancer-associated sequences described herein, provide an abundance of information which can be conelated with pathological conditions, predisposition to disease, drug testing, therapeutic monitoring, gene-disease causal linkages, identification of conelates of immunity and physiological status, among others. Although the data generated from the assays of the invention is suited for manual review and analysis, in a prefened embodiment, data processing using high-speed computers is utilized. An array of methods for indexing and retrieving biomolecular information is available. For example, U.S. Patents 6,023,659 and 5,966,712 disclose a relational database system for storing biomolecular sequence information in a manner that allows sequences to be catalogued and searched according to one or more protein function hierarchies. U.S. Patent 5,953,727 discloses a relational database having sequence records containing information in a format that allows a collection of partial-length DNA sequences to be catalogued and searched according to association with one or more sequencing projects for obtaining full-length sequences from the collection of partial length sequences. U.S. Patent 5,706,498 discloses a gene database retrieval system for making a retrieval of a gene sequence similar to a sequence data item in a gene database based on the degree of similarity between a key sequence and a target sequence. U.S. Patent 5,538,897 discloses a method using mass spectroscopy fragmentation patterns of peptides to identify amino acid sequences in computer databases by comparison of predicted mass spectra with experimentally-derived mass spectra using a closeness-of-fit measure. U.S. Patent 5,926,818 discloses a multi-dimensional database comprising a functionality for multidimensional data analysis described as on-line analytical processing (OLAP), which entails the consolidation of projected and actual data according to more than one consolidation path or dimension. U.S. Patent 5,295,261 reports a hybrid database structure in which the fields of each database record are divided into two classes, navigational and informational data, with navigational fields stored in a hierarchical topological map which can be viewed as a tree structure or as the merger of two or more such tree structures. See also Baxevanis, et al. (2001) Bioinformatics: A Practical Guuide to the Analysis of Genes and Proteins Wiley; Mount (2001) Bioinformatics: Sequence and Genome Analysis CSH Press, NY; Durbin, et al. (eds. 1999)
Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids Cambridge University Press; Baxevanis and Oeullette (eds. 1998) Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins (2d. ed.) Wiley-Liss; Rashidi and Buehler (1999) Bioinformatics: Basic Applications in Biological Science and Medicine CRC Press; Setubal, et al. (eds. 1997) Introduction to Computational Molecular Biology Brooks/Cole; Misener and Krawetz (eds. 2000) Bioinformatics: Methods and Protocols Humana Press; Higgins and Taylor (eds. 2000) Bioinformatics: Sequence, Structure, and Databanks: A Practical Approach Oxford University Press; Brown (2001) Bioinformatics: A Biologist's Guide to Biocomputing and the Internet Eaton Pub.; Han and Kamber (2000) Data Mining: Concepts and Techniques Kaufmann Pub.; and Waterman (1995) Introduction to Computational Biology: Maps, Sequences, and Genomes Chap and Hall. The present invention provides a computer database comprising a computer and software for storing in computer-retrievable form assay data records cross-tabulated, e.g., with data specifying the source of the target-containing sample from which each sequence specificity record was obtained.
In an exemplary embodiment, at least one of the sources of target-containing sample is from a control tissue sample known to be free of pathological disorders. In a variation, at least one of the sources is a known pathological tissue specimen, e.g., a neoplastic lesion or another tissue specimen to be analyzed for cancer. In another variation, the assay records cross-tabulate one or more of the following parameters for each target species in a sample: (1) a unique identification code, which can include, e.g., a target molecular structure and/or characteristic separation coordinate (e.g., electrophoretic coordinates); (2) sample source; and (3) absolute and/or relative quantity of the target species present in the sample.
The invention also provides for the storage and retrieval of a collection of target data in a computer data storage apparatus, which can include magnetic disks, optical disks, magneto- optical disks, DRAM, SRAM, SGRAM, SDRAM, RDRAM, DDR RAM, magnetic bubble memory devices, and other data storage devices, including CPU registers and on-CPU data storage anays. Typically, the target data records are stored as a bit pattern in an anay of magnetic domains on a magnetizable medium or as an anay of charge states or transistor gate states, such as an array of cells in a DRAM device (e.g., each cell comprised of a transistor and a charge storage area, which may be on the transistor). In one embodiment, the invention provides such storage devices, and computer systems built therewith, comprising a bit pattern encoding a protein expression fingerprint record comprising unique identifiers for at least 10 target data records cross-tabulated with target source. When the target is a peptide or nucleic acid, the invention preferably provides a method for identifying related peptide or nucleic acid sequences, comprising performing a computerized comparison between a peptide or nucleic acid sequence assay record stored in or retrieved from a computer storage device or database and at least one other sequence. The comparison can include a sequence analysis or comparison algorithm or computer program embodiment thereof (e.g., FASTA, TFASTA, GAP, BESTFIT) and/or the comparison may be of the relative amount of a peptide or nucleic acid sequence in a pool of sequences determined from a polypeptide or nucleic acid sample of a specimen.
The invention also preferably provides a magnetic disk, such as an IBM-compatible (DOS, Windows, Windows95/98/2000, Windows NT, OS/2) or other format (e.g., Linux, SunOS, Solaris, AK, SCO Unix, VMS, MV, Macintosh, etc.) floppy diskette or hard (fixed, Winchester) disk drive, comprising a bit pattern encoding data from an assay of the invention in a file format suitable for retrieval and processing in a computerized sequence analysis, comparison, or relative quantitation method. The invention also provides a network, comprising a plurality of computing devices linked via a data link, such as an Ethernet cable (coax or lOBaseT), telephone line, ISDN line, wireless network, optical fiber, or other suitable signal transmission medium, whereby at least one network device (e.g., computer, disk anay, etc.) comprises a pattern of magnetic domains (e.g., magnetic disk) and/or charge domains (e.g., an anay of DRAM cells) composing a bit pattern encoding data acquired from an assay of the invention.
The invention also provides a method for transmitting assay data that includes generating an electronic signal on an electronic communications device, such as a modem, ISDN terminal adapter, DSL, cable modem, ATM switch, or the like, wherein the signal includes (in native or encrypted format) a bit pattern encoding data from an assay or a database comprising a plurality of assay results obtained by the method of the invention.
In a prefened embodiment, the invention provides a computer system for comparing a query target to a database containing an anay of data structures, such as an assay result obtained by the method of the invention, and ranking database targets based on the degree of identity and gap weight to the target data. A central processor is preferably initialized to load and execute the computer program for alignment and/or comparison of the assay results. Data for a query target is entered into the central processor via an I/O device. Execution of the computer program results in the central processor retrieving the assay data from the data file, which comprises a binary description of an assay result.
The target data or record and the computer program can be fransfened to secondary memory, which is typically random access memory (e.g., DRAM, SRAM, SGRAM, or SDRAM). Targets are ranked according to the degree of conespondence between a selected assay characteristic (e.g., binding to a selected affinity moiety) and the same characteristic of the query target and results are output via an I/O device. For example, a central processor can be a conventional computer (e.g., Intel Pentium, PowerPC, Alpha, PA-8000, SPARC, MIPS 4400, MIPS 10000, VAX, etc.); a program can be a commercial or public domain molecular biology software package (e.g., UWGCG Sequence Analysis Software, Darwin); a data file can be an optical or magnetic disk, a data server, a memory device (e.g., DRAM, SRAM, SGRAM, SDRAM, EPROM, bubble memory, flash memory, etc.); an I/O device can be a terminal comprising a video display and a keyboard, a modem, an ISDN terminal adapter, an Ethernet port, a punched card reader, a magnetic strip reader, or other suitable I/O device. The invention also preferably provides the use of a computer system, such as that described above, which comprises: (1) a computer; (2) a stored bit pattern encoding a collection of peptide sequence specificity records obtained by the methods of the invention, which may be stored in the computer; (3) a comparison target, such as a query target; and (4) a program for alignment and comparison, typically with rank-ordering of comparison results on the basis of computed similarity values. See, e.g., Ewens and Grant (2001) Statistical Methods in
Bioinformatics: An Introduction Springer- Verlag. Mathematical approaches can also be used to conclude whether similarities or differences in the gene expression exhibited by different samples are significant. See, e.g., Golub, et al. (1999) Science 286:531-537; Duda, et al. (2001) Pattern Classification Wiley; and Hastie, et al. (2001) The Elements of Statistical Learning: Data Mining, Inference, and Prediction Springer- Verlag. One approach to determine whether a sample is more similar to or has maximum similarity with a given condition between the sample and one or more pools representing different conditions for comparison; the pool with the smallest vector angle is then chosen as the most similar to the biological sample among the pools compared. Characteristics of cancer-associated proteins
Cancer proteins of the present invention may be classified as secreted proteins, transmembrane proteins, or intracellular proteins. In one embodiment, the cancer protein is an intracellular protein. Intracellular proteins may be found in the cytoplasm and/or in the nucleus. Intracellular proteins are involved in all aspects of cellular function and replication (including, e.g., signaling pathways); abenant expression of such proteins often results in unregulated or disregulated cellular processes (see, e.g., Alberts, et al. (eds. 1994) Molecular Biology of the Cell (3d ed.) Garland). For example, many intracellular proteins have enzymatic activity such as protein kinase activity, protein phosphatase activity, protease activity, nucleotide cyclase activity, polymerase activity, and the like. Intracellular proteins also serve as docking proteins that are involved in organizing complexes of proteins, or targeting proteins to various subcellular localizations, and are involved in maintaining the structural integrity of organelles. An increasingly appreciated concept in characterizing proteins is the presence in the proteins of one or more structural motifs for which defined functions have been attributed. In addition to the highly conserved sequences found in the enzymatic domain of proteins, highly conserved sequences have been identified in proteins that are involved in protein-protein interaction. For example, Src-homology-2 (SH2) domains bind tyrosine-phosphorylated targets in a sequence dependent manner. PTB domains, which are distinct from SH2 domains, also bind tyrosine phosphorylated targets. SH3 domains bind to proline-rich targets. In addition, PH domains, tetratricopeptide repeats and WD domains to name only a few, have been shown to mediate protein-protein interactions. Some of these may also be involved in binding to phospholipids or other second messengers. These motifs can be identified on the basis of amino acid sequence; thus, an analysis of the sequence of proteins may provide insight into both the enzymatic potential of the molecule and/or molecules with which the protein may associate. One useful database is Pfam (protein families), which is a large collection of multiple sequence alignments and hidden Markov models covering many common protein domains. Versions are available via the internet from Washington University in St. Louis, the S anger Center in England, and the Karolinska Institute in Sweden. See, e.g., Bateman, et al. (2000) Nuc. Acids Res. 28:263-266; Sonnhammer, et al. (1997) Proteins 28:405-420 ; Bateman, et al. (1999) Nuc. Acids Res. 27:260-262; and Sonnhammer, et al. (1998) Nuc. Acids Res. 26:320-322.
In another embodiment, the cancer sequences are transmembrane proteins. Transmembrane proteins are molecules that span a phospholipid bilayer of a cell. They may have an intracellular domain, an extracellular domain, or both. The intracellular domains of such proteins may have a number of functions including those already described for intracellular proteins. For example, the intracellular domain may have enzymatic activity and/or may serve as a binding site for additional proteins. Frequently the intracellular domain of transmembrane proteins serves both roles. For example certain receptor tyrosine kinases have both protein kinase activity and SH2 domains. In addition, autophosphorylation of tyrosines on the receptor molecule itself, creates binding sites for additional SH2 domain containing proteins.
Transmembrane proteins may contain from one to many transmembrane domains. For example, receptor tyrosine kinases, certain cytokine receptors, receptor guanylyl cyclases and receptor serine/threonine protein kinases contain a single transmembrane domain. However, various other proteins including channels and adenylyl cyclases contain numerous transmembrane domains. Many important cell surface receptors such as G protein coupled receptors (GPCRs) are classified as "seven transmembrane domain" proteins, as they contain 7 membrane spanning regions. Characteristics of transmembrane domains include approximately 17 consecutive hydrophobic amino acids that may be followed by charged amino acids. Therefore, upon analysis of the amino acid sequence of a particular protein, the localization and number of transmembrane domains within the protein may be predicted (see, e.g., PSORT web site http://psort.nibb.ac.jp/). Important transmembrane protein receptors include, but are not limited to the insulin receptor, insulin-like growth factor receptor, human growth hormone receptor, glucose transporters, transferrin receptor, epidermal growth factor receptor, low density lipoprotein receptor, epidermal growth factor receptor, leptin receptor, and interieukin receptors, e.g., IL-1 receptor, IL-2 receptor, etc.
The extracellular domains of transmembrane proteins are diverse; however, conserved motifs are found repeatedly among various extracellular domains. Conserved structure and/or functions have been ascribed to different extracellular motifs. Many extracellular domains are involved in binding to other molecules. In one aspect, extracellular domains are found on receptors. Factors that bind the receptor domain include circulating ligands, which may be peptides, proteins, or small molecules such as adenosine and the like. For example, growth factors such as EGF, FGF, and PDGF are circulating growth factors that bind to their cognate receptors to initiate a variety of cellular responses. Other factors include cytokines, mitogenic factors, neurotrophic factors, and the like. Extracellular domains also bind to cell-associated molecules. In this respect, they may mediate cell-cell interactions. Cell-associated ligands can be tethered to the cell, e.g., via a glycosylphosphatidylinositol (GPI) anchor, or may themselves be transmembrane proteins. Extracellular domains may also associate with the extracellular matrix and contribute to the maintenance of the cell structure.
Cancer proteins that are transmembrane are particularly prefened in the present invention as they are readily accessible targets for immunotherapeutics, as are described herein. In addition, as outlined below, transmembrane proteins can be also useful in imaging modalities. Antibodies may be used to label such readily accessible proteins in situ. Alternatively, antibodies can also label intracellular proteins, in which case samples are typically permeablized to provide access to intracellular proteins. In addition, some membrane proteins can be processed to release a soluble protein, or to expose a residual fragment. Released soluble proteins may be useful diagnostic markers, processed residual protein fragments may be useful lung markers of disease.
It will also be appreciated that a transmembrane protein can be made soluble by removing transmembrane sequences, e.g., through recombinant methods. Furthermore, transmembrane proteins that have been made soluble can be made to be secreted through recombinant means by adding an appropriate signal sequence.
In another embodiment, the cancer proteins are secreted proteins; the secretion of which can be either constitutive or regulated. These proteins may have a signal peptide or signal sequence that targets the molecule to the secretory pathway. Secreted proteins are involved in numerous physiological events; e.g., if circulating, they often serve to transmit signals to various other cell types. The secreted protein may function in an autocrine manner (acting on the cell that secreted the factor), a paracrine manner (acting on cells in close proximity to the cell that secreted the factor), an endocrine manner (acting on cells at a distance, e.g, secretion into the blood stream), or exocrine (secretion, e.g., through a duct or to adjacent epithelial surface as sweat glands, sebaceous glands, pancreatic ducts, lacrimal glands, mammary glands, wax producing glands of the ear, etc.). Thus secreted molecules often find use in modulating or altering numerous aspects of physiology. Cancer proteins that are secreted proteins are particularly prefened in the present invention as they serve as good targets for diagnostic markers, e.g., for blood, plasma, serum, or stool tests. Those which are enzymes may be antibody or small molecule targets. Others may be useful as vaccine targets, e.g., via CTL mechanisms. Use of cancer nucleic acids
As described above, cancer sequence is initially identified by substantial nucleic acid and/or amino acid sequence homology or linkage to the cancer sequences outlined herein. Such homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, using either homology programs or hybridization conditions. Typically, linked sequences on a mRNA are found on the same molecule.
As detailed elsewhere, percent identity can be determined using an algorithm such as BLAST. A prefened method utilizes the BLASTN module of WU-BLAST-2 set to the default parameters, with overlap span and overlap fraction set to 1 and 0.125, respectively. Alignment may include the introduction of gaps in the sequences to be aligned. In addition, for sequences which contain either more or fewer nucleotides than those of the nucleic acids described, the percentage of homology may be determined based on the number of homologous nucleosides in relation to the total number of nucleosides. Thus, e.g., homology of sequences shorter than those of the sequences identified will be determined using the number of nucleosides in the shorter sequence.
In one embodiment, the nucleic acid homology is determined through hybridization studies. Thus, e.g., nucleic acids which hybridize under high stringency to a described nucleic acid, or its complement, or is also found on naturally occurring mRNAs is considered a cancer sequence. In another embodiment, less stringent hybridization conditions are used; e.g., moderate or low stringency conditions may be used; see Ausubel, supra, and Tijssen, supra. The cancer nucleic acid sequences of the invention, e.g., the sequences in Tables 1-68, can be fragments of larger genes, e.g., they are nucleic acid segments. "Genes" in this context includes coding regions, non-coding regions, and mixtures of coding and non-coding regions. Accordingly, using the sequences provided herein, extended sequences, in either direction, of the cancer genes can be obtained, using techniques well known for cloning either longer sequences or the full length sequences; see Ausubel, et al., supra. Much can be done by informatics and many sequences can be clustered to include multiple sequences conesponding to a single gene, e.g., systems such as UniGene (see, http://www.ncbi.nlm.nih.gov/UniGene/).
Once a cancer nucleic acid is identified, it can be cloned and, if necessary, its constituent parts recombined to form the entire cancer nucleic acid coding regions or the entire mRNA sequence. Once isolated from its natural source, e.g., contained within a plasmid or other vector or excised therefrom as a linear nucleic acid segment, the recombinant cancer nucleic acid can be further used as a probe to identify and isolate other cancer nucleic acids, e.g., extended coding regions. It can also be used as a "precursor" nucleic acid to make modified or variant cancer nucleic acids and proteins.
The cancer nucleic acids of the present invention are used in several ways. In one embodiment, nucleic acid probes to the cancer nucleic acids are made and attached to biochips to be used in screening and diagnostic methods, as outlined below, or for administration, e.g., for gene therapy, vaccine, RNAi, and/or antisense applications. Alternatively, cancer nucleic acids that include coding regions of cancer proteins can be put into expression vectors for the expression of cancer proteins, again for screening purposes or for administration to a patient. In a prefened embodiment, nucleic acid probes to cancer nucleic acids (both the nucleic acid sequences outlined in the figures and/or the complements thereof) are made. The nucleic acid probes attached to the biochip are designed to be substantially complementary to the cancer nucleic acids, e.g., the target sequence (either the target sequence of the sample or to other probe sequences, e.g., in sandwich assays), such that hybridization of the target sequence and the probes of the present invention occurs. As outlined below, this complementarity need not be perfect; there may be any number of base pair mismatches which will interfere with hybridization between the target sequence and the single stranded nucleic acids of the present invention. However, if the number of mutations is so great that no hybridization can occur under even the least stringent of hybridization conditions, the sequence is not a complementary target sequence. Thus, by "substantially complementary" herein is meant that the probes are sufficiently complementary to the target sequences to hybridize under normal reaction conditions, particularly high stringency conditions, as outlined herein.
A nucleic acid probe is generally single stranded but can be partially single and partially double stranded. The strandedness of the probe is dictated by the structure, composition, and properties of the target sequence. In general,lhe nucleic acid probes range from about 8-100 bases long, with from about 10-80 bases being prefened, and from about 30-50 bases being particularly prefened. That is, generally whole genes are not used. In some embodiments, much longer nucleic acids can be used, up to hundreds of bases.
In a preferred embodiment, more than one probe per sequence is used, with either overlapping probes or probes to different sections of the target being used. That is, two, three, four or more probes, with three being prefened, are used to build in a redundancy for a particular target. The probes can be overlapping (e.g., have some sequence in common), or separate. In some cases, PCR primers may be used to amplify signal for higher sensitivity. Nucleic acids can be attached or immobilized to a solid support in a wide variety of ways. By "immobilized" and grammatical equivalents herein is meant the association or binding between the nucleic acid probe and the solid support is sufficient to be stable under the conditions of binding, washing, analysis, and removal as outlined. The binding can typically be covalent or non-covalent. By "non-covalent binding" and grammatical equivalents herein is meant one or more of electrostatic, hydrophilic, and hydrophobic interactions. Included in non- covalent binding is the covalent attachment of a molecule, e.g., streptavidin to the support and the non-covalent binding of the biotinylated probe to the streptavidin. By "covalent binding" and grammatical equivalents herein is meant that the two moieties, the solid support and the probe, are attached by at least one bond, including sigma bonds, pi bonds, and coordination bonds. Covalent bonds can be formed directly between the probe and the solid support or can be formed by a cross linker or by inclusion of a specific reactive group on either the solid support or the probe or both molecules. Immobilization may also involve a combination of covalent and non-covalent interactions.
In general, the probes are attached to the biochip in a wide variety of ways. As described herein, the nucleic acids can either be synthesized first, with subsequent attachment to the biochip, or can be directly synthesized on the biochip. The biochip comprises a suitable solid substrate. By "substrate" or "solid support" or
— other grammatical equivalents herein is meant a material that can be modified for the attachment or association of the nucleic acid probes and is amenable to at least one detection method. Often, the substrate may contain discrete individual sites appropriate for individual partitioning and identification. The number of possible substrates is very large, and include, but are not limited to, glass and modified or functionalized glass, plastics (including acrylics, polystyrene and copolymers of styrene and other materials, polypropylene, polyethylene, polybutylene, polyurethanes, TeflonJ, etc.), polysaccharides, nylon or nitrocellulose, resins, silica or silica-based materials including silicon and modified silicon, carbon, metals, inorganic glasses, plastics, etc. In general, the substrates allow optical detection and do not appreciably fluoresce. See WO 0055627.
Generally the substrate is planar, although other configurations of substrates may be used as well. For example, the probes may be placed on the inside surface of a tube for flow- through sample analysis to minimize sample volume. Similarly, the substrate may be flexible, such as a flexible foam, including closed cell foams made of particular plastics.
In a prefened embodiment, the surface of the biochip and the probe may be derivatized with chemical functional groups for subsequent attachment of the two. Thus, e.g., the biochip is derivatized with a chemical functional group including, but not limited to, amino groups, carboxy groups, oxo groups, and thiol groups, with amino groups being particularly prefened. Using these functional groups, the probes can be attached using functional groups on the probes. For example, nucleic acids containing amino groups can be attached to surfaces comprising amino groups, e.g., using linkers; e.g., homo-or hetero-bifunctional linkers as are well known (see 1994 Pierce Chemical Company catalog, technical section on cross-linkers, pages 155-
200). In addition, in some cases, additional linkers, such as alkyl groups (including substituted and heteroalkyl groups) may be used.
In this embodiment, oligonucleotides are synthesized, and then attached to the surface of the solid support. Either the 5' or 3' terminus may be attached to the solid support, or attachment may be via linkage to an internal nucleoside. In another embodiment, the immobilization to the solid support may be very strong, yet non-covalent. For example, biotinylated oligonucleotides can be made, which bind to surfaces covalently coated with streptavidin, resulting in attachment.
Alternatively, the oligonucleotides may be synthesized on the surface. For example, photoactivation techniques utilizing photopolymerization compounds and techniques are used. In a prefened embodiment, the nucleic acids can be synthesized in situ, using known photolithographic techniques, such as those described in WO 95/25116; WO 95/35505; U.S. Patent Nos. 5,700,637 and 5,445,934; and references cited within, all of which are expressly incorporated by reference; these methods of attachment form the basis of the Affymetrix GeneChip™ technology.
Often, amplification-based assays are performed to measure the expression level of cancer-associated sequences. These assays are typically performed in conjunction with reverse transcription. In such assays, a cancer-associated nucleic acid sequence acts as a template in an amplification reaction (e.g., Polymerase Chain Reaction, or PCR). In a quantitative amplification, the amount of amplification product will be proportional to the amount of template in the original sample. Comparison to appropriate controls provides a measure of the amount of cancer-associated RNA. Methods of quantitative amplification are well known. Detailed protocols for quantitative PCR are provided, e.g., in Innis, et al. (1990) PCR Protocols. A Guide to Methods and Applications Academic Press.
In some embodiments, a TaqMan based assay is used to measure expression. TaqMan based assays use a fluorogenic oligonucleotide probe that contains a 5' fluorescent dye and a 3' quenching agent. The probe hybridizes to a PCR product, but cannot itself be extended due to a blocking agent at the 3' end. When the PCR product is amplified in subsequent cycles, the 5' nuclease activity of the polymerase, e.g., AmpliTaq, results in the cleavage of the TaqMan probe. This cleavage separates the 5' fluorescent dye and the 3' quenching agent, thereby resulting in an increase in fluorescence as a function of amplification (see, e.g., literature provided by Perkin-Elmer, e.g., www2.perkin-elmer.com).
Other suitable amplification methods include, but are not limited to, ligase chain reaction (LCR) (see Wu and Wallace (1989) Genomics 4:560-569, Landegren, et al. (1988) Science 241:1077-1080, and Baπinger, et al. (1990) Gene 89:117-122), transcription amplification (Kwoh, et al. (1989) Proc. Natl. Acad. Sci. USA 86:1173-1177), self-sustained sequence replication (Guatelli, et al. (1990) Proc. Nat. Acad. Sci. USA 87:1874-1878), dot PCR, linker adapter PCR, etc. Expression of cancer proteins from nucleic acids
In a prefened embodiment, cancer nucleic acids, e.g., encoding cancer proteins, are used to make a variety of expression vectors to express cancer proteins which can then be used in screening assays, as described below. Expression vectors and recombinant DNA technology are -well known (see, e.g., Ausubel, supra, and Fernandez and Hoeffler (eds. 1999) Gene Expression Systems Academic Press) to express proteins. The expression vectors may be either self- replicating extrachromosomal vectors or vectors which integrate into a host genome. Generally, these expression vectors include transcriptional and translational regulatory nucleic acid operably linked to the nucleic acid encoding the cancer protein. The term "control sequences" refers to DNA sequences used for the expression of an operably linked coding sequence in a particular host organism. Control sequences that are suitable for prokaryotes, e.g., include a promoter, optionally an operator sequence, and a ribosome binding site. Eukaryotic cells are known to utilize promoters, polyadenylation signals, and enhancers. Nucleic acid is "operably linked" when it is placed into a functional relationship with another nucleic acid sequence. For example, DNA for a presequence or secretory leader is operably linked to DNA for a polypeptide if it is expressed as a preprotein that participates in the secretion of the polypeptide; a promoter or enhancer is operably linked to a coding sequence if it affects the transcription of the sequence; or a ribosome binding site is operably linked to a coding sequence if it is positioned so as to facilitate translation. Generally, "operably linked" means that the DNA sequences being linked are contiguous, and, in the case of a secretory leader, contiguous and in reading phase. However, enhancers do not have to be contiguous. Linking is typically accomplished by ligation at convenient restriction sites. If such sites do not exist, synthetic oligonucleotide adaptors or linkers are used in accordance with conventional practice. Transcriptional and translational regulatory nucleic acid will generally be appropriate to the host cell used to express the cancer protein. Numerous types of appropriate expression vectors and suitable regulatory sequences are known for a variety of host cells.
In general, transcriptional and translational regulatory sequences may include, but are not limited to, promoter sequences, ribosomal binding sites, transcriptional start and stop sequences, translational start and stop sequences, and enhancer or activator sequences. In a prefened embodiment, the regulatory sequences include a promoter and transcriptional start and stop sequences.
Promoter sequences may be either constitutive or inducible promoters. The promoters may be either naturally occurring promoters or hybrid promoters. Hybrid promoters, which combine elements of more than one promoter, are also known, and are useful in the present invention. An expression vector may comprise additional elements. For example, the expression vector may have two replication systems, thus allowing it to be maintained in two organisms, e.g., in mammalian or insect cells for expression and in a prokaryotic host for cloning and amplification. Furthermore, for integrating expression vectors, the expression vector often contains at least one sequence homologous to the host cell genome, and preferably two homologous sequences which flank the expression construct. The integrating vector may be directed to a specific locus in the host cell by selecting the appropriate homologous sequence for inclusion in the vector. Constructs for integrating vectors are available. See, e.g., Fernandez and Hoeffler, supra; and Kitamura, et al. (1995) Proc. Nat'l Acad. Sci. USA 92:9146- 9150. In addition, in a prefened embodiment, the expression vector contains a selectable marker gene to allow the selection of transformed host cells. Selection genes are well known and will vary with the host cell used. The cancer proteins of the present invention are usually produced by culturing a host cell transformed with an expression vector containing nucleic acid encoding a cancer protein, under the appropriate conditions to induce or cause expression of the cancer protein. Conditions appropriate for cancer protein expression will vary with the choice of the expression vector and the host cell, and will be easily ascertained through routine experimentation or optimization. For example, the use of constitutive promoters in the expression vector will require optimizing the growth and proliferation of the host cell, while the use of an inducible promoter requires the appropriate growth conditions for induction. In addition, in some embodiments, the timing of the harvest is important. For example, the baculoviral systems used in insect cell expression are lytic viruses, and thus harvest time selection can be crucial for product yield.
Appropriate host cells include yeast, bacteria, archaebacteria, fungi, and insect and animal cells, including mammalian cells. Of particular interest are Saccharomyces cerevisiae and other yeasts, E. coli, Bacillus subtilis, Sf9 cells, C129 cells, 293 cells, Neurospora, BHK, CHO, COS, HeLa cells, HUVEC (human umbilical vein endothelial cells), THP1 cells (a macrophage cell line), and various other human cells and cell lines.
In a prefened embodiment, the cancer proteins are expressed in mammalian cells. Mammalian expression systems may be used, and include retroviral and adenoviral systems. One expression vector system is a retroviral vector system such as is generally described in PCT/US97/01019 and PCT/US97/01048. Of particular use as mammalian promoters are the promoters from mammalian viral genes, since the viral genes are often highly expressed and have a broad host range. Examples include the SV40 early promoter, mouse mammary tumor virus LTR promoter, adenovirus major late promoter, herpes simplex virus promoter, and the CMV promoter (see, e.g., Fernandez and Hoeffler, supra). Typically, transcription termination and polyadenylation sequences recognized by mammalian cells are regulatory regions located 3' to the translation stop codon and thus, together with the promoter elements, flank the coding sequence. Examples of transcription terminator and polyadenlyation signals include those derived from SV40.
Methods of introducing exogenous nucleic acid into mammalian hosts, as well as other hosts, are available, and will vary with the host cell used. Techniques include dextran-mediated transfection, calcium phosphate precipitation, polybrene mediated transfection, protoplast fusion, electroporation, viral infection, encapsulation of the polynucleotide(s) in liposomes, and direct microinjection of the DNA into nuclei. In a prefened embodiment, cancer proteins are expressed in bacterial systems. Promoters from bacteriophage may also be used. In addition, synthetic promoters and hybrid promoters are also useful; e.g., the tac promoter is a hybrid of the trp and lac promoter sequences. Furthermore, a bacterial promoter can include naturally occurring promoters of non- bacterial origin that have the ability to bind bacterial RNA polymerase and initiate transcription. In addition to a functioning promoter sequence, an efficient ribosome binding site is desirable. The expression vector may also include a signal peptide sequence that provides for secretion of the cancer protein in bacteria. The protein is either secreted into the growth media (gram- positive bacteria) or into the periplasmic space, located between the inner and outer membrane of the cell (gram-negative bacteria). The bacterial expression vector may also include a selectable marker gene to allow for the selection of bacterial strains that have been transformed. Suitable selection genes include genes which render the bacteria resistant to drugs such as ampicillin, chloramphenicol, erytbromycin, kanamycin, neomycin, and tetracycline. Selectable markers also include biosynthetic genes, such as those in the histidine, tryptophan, and leucine biosynthetic pathways. These components are assembled into expression vectors. Expression vectors for bacteria are well known, and include vectors for Bacillus subtilis, E. coli, Streptococcus cremoris, and Streptococcus lividans, among others (e.g., Fernandez and Hoeffler, supra). The bacterial expression vectors are transformed into bacterial host cells using techniques such as calcium chloride treatment, electroporation, and others. In one embodiment, cancer proteins are produced in insect cells using, e.g., expression vectors for the transformation of insect cells, and in particular, baculo virus-based expression vectors.
In a prefened embodiment, a cancer protein is produced in yeast cells. Yeast expression systems are well known, and include expression vectors for Saccharomyces cerevisiae, Candida albicans and C. maltosa, Hansenula polymorpha, Kluyveromyces fragilis and K. lactis, Pichia guillerimondii and P. pastoris, Schizosaccharomyces pombe, and Yanowia lipolytica.
The cancer protein may also be made as a fusion protein, using available techniques. Thus, e.g., for the creation of monoclonal antibodies, if the desired epitope is small, the cancer protein may be fused to a carrier protein to form an immunogen. Alternatively, the cancer protein may be made as a fusion protein to increase expression, or for other reasons. For example, when the cancer protein is a cancer peptide, the nucleic acid encoding the peptide may be linked to other nucleic acid for expression purposes. Fusion with detection epitope tags can be made, e.g., with FLAG, His6, myc, HA, etc.
In a prefened embodiment, the cancer protein is purified or isolated after expression. Cancer proteins may be isolated or purified in a variety of ways depending on what other components are present in the sample and the requirements for purified product, e.g., natural conformation or denatured. Standard purification methods include ammonium sulfate precipitations, electrophoretic, molecular, immunological, and chromatographic techniques, including ion exchange, hydrophobic, affinity, and reverse-phase HPLC chromatography, and chromatofocusing. For example, the cancer protein may be purified using a standard anti- cancer protein antibody column. Ultrafiltration and diafiltration techniques, in conjunction with protein concentration, are also useful. See, e.g., Walsh (2002) Proteins: Biochemistry and Biotechnology Wiley; Hardin, et al. (eds. 2001) Cloning, Gene Expression and Protein Purification Oxford Univ. Press; Wilson, et al. (eds. 2000) Encyclopedia of Separation Science Academic Press; and Scopes (1993) Protein Purification Springer-Verlag. The degree of purification necessary will vary depending on the use of the cancer protein. In some instances no purification will be necessary.
Once expressed and purified if necessary, the cancer proteins and nucleic acids are useful in a number of applications. They may be used as immunoselection reagents, as vaccine reagents, as screening agents, therapeutic entities, for production of antibodies, as transcription or translation inhibitors, etc. Variants of cancer proteins
Also included within one embodiment of cancer proteins are amino acid variants of the naturally occurring sequences, as determined herein. Preferably, the variants are preferably greater than about 75% homologous to the wild-type sequence, more preferably greater than about 80%, even more preferably greater than about 85%, and most preferably greater than 90%. In some embodiments the homology will be as high as about 93-95% or 98%. As for nucleic acids, homology in this context means sequence similarity or identity, with identity being prefened. This homology will be determined using standard techniques, as are outlined above for nucleic acid homologies. Cancer proteins of the present invention may be shorter or longer than the wild type amino acid sequences. Thus, in a prefened embodiment, included within the definition of cancer proteins are portions or fragments of the wild type sequences herein. In addition, as outlined above, the cancer nucleic acids of the invention may be used to obtain additional coding regions, and thus additional protein sequence.
In one embodiment, the cancer proteins are derivative or variant cancer proteins as compared to the wild-type sequence. That is, as outlined more fully below, the derivative cancer peptide will often contain at least one amino acid substitution, deletion, or insertion, with amino acid substitutions being particularly prefened. The amino acid substitution, insertion, or deletion may occur at many residue positions within the cancer peptide.
Also included within one embodiment of cancer proteins of the present invention are amino acid sequence variants. These variants typically fall into one or more of three classes: substitutional, insertional, or deletional variants. These variants ordinarily are prepared by site specific mutagenesis of nucleotides in the DNA encoding the cancer protein, using cassette or PCR mutagenesis or other techniques, to produce DNA encoding the variant, and thereafter expressing the DNA in recombinant cell culture as outlined above. However, variant cancer protein fragments having up to about 100-150 residues may be prepared by in vitro synthesis using established techniques. Amino acid sequence variants are characterized by the predetermined nature of the variation, a feature that sets them apart from naturally occurring allelic or interspecies variation of the cancer protein amino acid sequence. The variants typically exhibit a similar qualitative biological activity as a naturally occurring analogue, although variants can also be selected which have modified characteristics. While the site or region for introducing an amino acid sequence variation is often predetermined, the mutation per se need not be predetermined. For example, in order to optimize the performance of a mutation at a given site, random mutagenesis may be conducted at the target codon or region and the expressed cancer variants screened for the optimal combination of desired activity. Techniques for making substitution mutations at predetermined sites in DNA having a known sequence are well known, e.g., Ml 3 primer mutagenesis and PCR mutagenesis. Screening of mutants is often done using assays of cancer protein activities.
Amino acid substitutions are typically of single residues; insertions usually will be on the order of from about 1-20 amino acids, although considerably larger insertions may be tolerated. Deletions generally range from about 1-20 residues, although in some cases deletions may be much larger.
Substitutions, deletions, insertions, or combination thereof may be used to arrive at a final derivative. Generally these changes are done on a few amino acids to minimize the alteration of the molecule. However, larger changes may be tolerated in certain circumstances. When small alterations in the characteristics of the cancer protein are desired, substitutions are generally made in accordance with the amino acid substitution relationships described.
The variants typically exhibit essentially the same qualitative biological activity and will elicit the same immune response as a naturally-occurring analog, although variants also are selected to modify the characteristics of cancer proteins as needed. Alternatively, the variant may be designed such that a biological activity of the cancer protein is altered. For example, glycosylation sites may be added, altered, or removed.
Substantial changes in function or immunological identity are sometimes made by selecting substitutions that are less conservative than those described above. For example, substitutions may be made which more significantly affect: the structure of the polypeptide backbone in the area of the alteration, for example the alpha-helical or beta-sheet structure; the charge or hydrophobicity of the molecule at the target site; or the bulk of the side chain. Substitutions which generally are expected to produce the greatest changes in the polypeptide's properties are those in which (a) a hydrophilic residue, e.g., serine or threone is substituted for (or by) a hydrophobic residue, e.g., leucine, isoleucine, phenylalanine, valine, or alanine; (b) a cysteine or proline is substituted for (or by) another residue; (c) a residue having an electropositive side chain, e.g., lysine, arginine, or histidine, is substituted for (or by) an electronegative residue, e.g., glutamic or aspartic acid; (d) a residue having a bulky side chain, e.g., phenylalanine, is substituted for (or by) one not having a side chain, e.g., glycine; or (e) a proline residue is incoφorated or substituted, which changes the degree of rotational freedom of the peptidyl bond.
Variants typically exhibit a similar qualitative biological activity and will elicit the same immune response as the naturally-occurring analog, although variants also are selected to modify the characteristics of the skin cancer proteins as needed. Alternatively, the variant may be designed such that the biological activity of the cancer protein is altered. For example, glycosylation sites may be altered or removed.
Covalent modifications of cancer polypeptides are included within the scope of this invention. One type of covalent modification includes reacting targeted amino acid residues of a cancer polypeptide with an organic derivatizing agent that is capable of reacting with selected side chains or the N-or C-terminal residues of a cancer polypeptide. Derivatization with bifunctional agents is useful, for instance, for crosslinking cancer polypeptides to a water- insoluble support matrix or surface for use in a method for purifying anti-cancer polypeptide antibodies or screening assays, as is more fully described below. Commonly used crosslinking agents include, e.g., l,l-bis(diazoacetyl)-2-phenylethane, glutaraldehyde, N- hydroxysuccinimide esters, e.g., esters with 4-azidosalicylic acid, homobifunctional imidoesters, including disuccinimidyl esters such as 3,3'-dithiobis(succinimidylpropionate), bifunctional maleimides such as bis-N-maleimido-l,8-octane and agents such as methyl-3-((p- azidophenyl)dithio)propioimidate.
Other modifications include deamidation of glutaminyl and asparaginyl residues to the conesponding glutamyl and aspartyl residues, respectively, hydroxylation of proline and lysine, phosphorylation of hydroxyl groups of serinyl, threonyl, or tyrosyl residues, methylation of the amino groups of the lysine, arginine, and histidine side chains (e.g., pp. 79-86, Creighton (1992) Proteins: Structure and Molecular Properties Freeman), acetylation of the N-terminal amine, and amidation of a C-terminal carboxyl group.
Another type of covalent modification of the cancer polypeptide included within the scope of this invention comprises altering the native glycosylation pattern of the polypeptide. "Altering the native glycosylation pattern" is intended for purposes herein to mean deleting one or more carbohydrate moieties found in native sequence cancer polypeptide, and/or adding one or more glycosylation sites that are not present in the native sequence cancer polypeptide. Glycosylation patterns can be altered in many ways. Different cell types to express cancer- associated sequences can result in different glycosylation patterns.
Addition of glycosylation sites to cancer polypeptides may also be accomplished by altering the amino acid sequence thereof. The alteration may be made, e.g., by the addition of, or substitution by, one or more serine or threonine residues to the native sequence cancer polypeptide (for O-linked glycosylation sites). The cancer amino acid sequence may optionally be altered through changes at the DNA level, particularly by mutating the DNA encoding the cancer polypeptide at preselected bases such that codons are generated that will translate into the desired amino acids.
Another means of increasing the number of carbohydrate moieties on the cancer polypeptide is by chemical or enzymatic coupling of glycosides to the polypeptide. See, e.g., WO 87/05330; pp. 259-306 in Aplin and Wriston (1981) CRC Crit. Rev. Biochem. Removal of carbohydrate moieties present on the cancer polypeptide may be accomplished chemically or enzymatically or by mutational substitution of codons encoding for amino acid residues that serve as targets for glycosylation. Chemical deglycosylation techniques are applicable. See, e.g., Sojar and Bahl (1987) Arch. Biochem. Biophys. 259:52-57 and Edge, et al. (1981) Anal. Biochem. 118:131-137. Enzymatic cleavage of carbohydrate moieties on polypeptides can be achieved by the use of a variety of endo-and exo-glycosidases. See, e.g., Thotakura, et al. (1987) Meth. Enzymol. 138:350-359.
Another type of covalent modification of cancer comprises linking the cancer polypeptide to one of a variety of nonproteinaceous polymers, e.g., polyethylene glycol, polypropylene glycol, or polyoxyalkylenes, in the manner set forth in U.S. Patent Nos. 4,640,835; 4,496,689; 4,301,144; 4,670,417; 4,791,192, or 4,179,337. Cancer polypeptides of the present invention may also be modified in a way to form chimeric molecules comprising a cancer polypeptide fused to another heterologous polypeptide or amino acid sequence. In one embodiment, such a chimeric molecule comprises a fusion of a cancer polypeptide with a tag polypeptide which provides an epitope to which an anti-tag antibody can selectively bind. The epitope tag is generally placed at the amino-or carboxyl- terminus of the cancer polypeptide. The presence of such epitope-tagged forms of a cancer polypeptide can be detected using an antibody against the tag polypeptide. Also, provision of the epitope tag enables the cancer polypeptide to be readily purified by affinity purification using an anti-tag antibody or another type of affinity matrix that binds to the epitope tag. In an alternative embodiment, the chimeric molecule may comprise a fusion of a cancer polypeptide with an immunoglobulin or a particular region of an immunoglobulin. For a bivalent form of the chimeric molecule, such a fusion coulcbbe to the Fc region of an IgG molecule.
Various tag polypeptides and their respective antibodies are available. Examples include poly-histidine (poly-his) or poly-histidine-glycine (poly-his-gly) tags; HIS6 and metal chelation tags, the flu HA tag polypeptide and its antibody 12CA5 (Field, et al. (1988) Mol. Cell. Biol. 8:2159-2165); the c-myc tag and the 8F9, 3C7, 6E10, G4, B7, and 9E10 antibodies thereto (Evan, et al. (1985) Molecular and Cellular Biology 5:3610-3616); and the Heφes Simplex virus glycoprotein D (gD) tag and its antibody (Paborsky, et al. (1990) Protein Engineering 3(6):547-553). Other tag polypeptides include the Flag-peptide (Hopp, et al. (1988) BioTechnology 6:1204-1210); the KT3 epitope peptide (Martin, et al. (1992) Science 255:192-194); tubulin epitope peptide (Skinner, et al. (1991) J. Biol. Chem. 266:15163-15166); and the T7 gene 10 protein peptide tag (Lutz-Freyermuth, et al. (1990) Proc. Natl. Acad. Sci. USA 87:6393-6397). Also included are other cancer proteins of the cancer family, and cancer proteins from other organisms, which are cloned and expressed as outlined below. Thus, probe or degenerate polymerase chain reaction (PCR) primer sequences may be used to find other related cancer proteins from humans or other organisms. Particularly useful probe and/or PCR primer sequences include the unique areas of the cancer nucleic acid sequence. Prefened PCR primers are from about 15-35 nucleotides in length, with from about 20-30 being prefened, and may contain inosine as needed. The conditions for PCR reaction have been well described (e.g., Innis, PCR Protocols, supra).
In addition, cancer proteins can be made that are longer than those encoded by the nucleic acids of the Tables, e.g., by the elucidation of extended sequences, the addition of epitope or purification tags, the addition of other fusion sequences, etc.
Cancer proteins may also be identified as being encoded by cancer nucleic acids. Thus, cancer proteins are encoded by nucleic acids that will hybridize to the sequences of the sequence listings, or their complements, as outlined herein. Antibodies to cancer proteins
In a prefened embodiment, when the cancer protein is to be used to generate antibodies, e.g., for immunotherapy or immunodiagnosis, the cancer protein should share at least one epitope or determinant with the full length protein. By "epitope" or "determinant" herein is typically meant a portion of a protein which will generate and/or bind an antibody or T-cell receptor in the context of MHC. Thus, in most instances, antibodies made to a smaller cancer protein will be able to bind to the full-length protein, particularly linear epitopes. In a prefened embodiment, the epitope is unique; that is, antibodies generated to a unique epitope show little or no cross-reactivity. In a prefened embodiment, the epitope is selected from a protein sequence set out in the tables. Methods of preparing polyclonal antibodies exist (e.g., Coligan, supra; and Harlow and
Lane, supra). Polyclonal antibodies can be raised in a mammal, e.g., by one or more injections of an immunizing agent and, if desired, an adjuvant. Typically, the immunizing agent and/or adjuvant will be injected in the mammal by multiple subcutaneous or intraperitoneal injections. The immunizing agent may include a protein encoded by a nucleic acid of Tables 1-68 or fragment thereof or a fusion protein thereof. It may be useful to conjugate the immunizing agent to a protein known to be immunogenic in the mammal being immunized. Examples of such immunogenic proteins include but are not limited to keyhole limpet hemocyanin, serum albumin, bovine thyroglobulin, and soybean trypsin inhibitor. Examples of adjuvants which may be employed include Freund's complete adjuvant and MPL-TDM adjuvant (monophosphoryl Lipid A, synthetic trehalose dicorynomycolate). Various immunization protocols may be used. The antibodies may, alternatively, be monoclonal antibodies. Monoclonal antibodies may be prepared using hybridoma methods, such as those described by Kohler and Milstein (1975) Nature 256:495. In a hybridoma method, a mouse, hamster, or other appropriate host animal, is typically immumzed with an immunizing agent to elicit lymphocytes that produce or are capable of producing antibodies that will specifically bind to the immunizing agent. Alternatively, the lymphocytes may be immunized in vitro. The immunizing agent will typically include a polypeptide encoded by a nucleic acid of the tables or fragment thereof, or a fusion protein thereof. Generally, either peripheral blood lymphocytes ("PBLs") are used if cells of human origin are desired, or spleen cells or lymph node cells are used if non-human mammalian sources are desired. The lymphocytes are then fused with an immortalized cell line using a suitable fusing agent, such as polyethylene glycol, to form a hybridoma cell (e.g., pp. 59-103 in Goding (1986) Monoclonal Antibodies: Principles and Practice Academic Press). Immortalized cell lines are usually transformed mammalian cells, particularly myeloma cells of rodent, bovine, or human origin. Usually, rat or mouse myeloma cell lines are employed. The hybridoma cells may be cultured in a suitable culture medium that preferably contains one or more substances that inhibit the growth or survival of the unfused, immortalized cells. For example, if the parental cells lack the enzyme hypoxanthine guanine phosphoribosyl transferase (HGPRT or HPRT), the culture medium for the hybridomas typically will include hypoxanthine, aminopterin, and thymidine ("HAT medium"), which substances prevent the growth of HGPRT-deficient cells. In one embodiment, the antibodies are bispecific antibodies. Bispecific antibodies are monoclonal, preferably human or humanized, antibodies that have binding specificities for at least two different antigens or that have binding specificities for two epitopes on the same antigen. In one embodiment, one of the binding specificities is for a protein encoded by a nucleic acid of the tables or a fragment thereof, the other one is for another antigen, and preferably for a cell-surface protein or receptor or receptor subunit, preferably one that is tumor specific. Alternatively, tetramer-type technology may create multivalent reagents. In a prefened embodiment, the antibodies to cancer protein are capable of reducing or eliminating a biological function of a cancer protein, in a naked form or conjugated to an effector moiety, as is described below. That is, the addition of anti-cancer protein antibodies (either polyclonal or preferably monoclonal) to cancer tissue (or cells containing cancer) may reduce or eliminate the cancer. Generally, at least a 25% decrease in activity, growth, size, or the like is prefened, with at least about 50% being particularly prefened and about a 95-100% decrease being especially prefened.
In a prefened embodiment the antibodies to the cancer proteins are humanized antibodies (e.g., Xenerex Biosciences, Medarex, Inc., Abgenix, Inc., Protein Design Labs, Inc.) Humanized forms of non-human (e.g., murine) antibodies are chimeric molecules of immunoglobulins, immunoglobulin chains or fragments thereof (such as Fv, Fab, Fab', F(ab')2 or other antigen-binding subsequences of antibodies) which contain minimal sequence derived from non-human immunoglobulin. Humanized antibodies include human immunoglobulins (recipient antibody) in which residues from a complementary determining region (CDR) of the recipient are replaced by residues from a CDR of a non-human species (donor antibody) such as mouse, rat, or rabbit having the desired specificity, affinity, and capacity. In some instances, Fv framework residues of a human immunoglobulin are replaced by conesponding non-human residues. Humanized antibodies may also comprise residues which are found neither in the recipient antibody nor in the imported CDR or framework sequences. In general, a humanized antibody will comprise substantially all of at least one, and typically two, variable domains, in which all or substantially all of the CDR regions conespond to those of a non-human immunoglobulin and all or substantially all of the framework (FR) regions are those of a human immunoglobulin consensus sequence. The humanized antibody optimally also will typically comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin (Jones, et al. (1986) Nature 321 :522-525; Riechmann, et al. (1988) Nature 332:323-329; and Presta (1992) Cun. Op. Struct. Biol. 2:593-596). Humanization can be essentially performed following the method of Winter and co-workers (Jones, et al. (1986) Nature 321:522-525; Riechmann, et al. (1988) Nature 332:323-327; Verhoeyen, et al. (1988) Science 239:1534-1536), by substituting rodent CDRs or CDR sequences for conesponding sequences of a human antibody. Accordingly, such humanized antibodies are chimeric antibodies (U.S. Patent No. 4,816,567), wherein substantially less than an intact human variable domain has been substituted by conesponding sequence from a non-human species. Human antibodies can also be produced using phage display libraries (Hoogenboom and Winter (1992) J. Mol. Biol. 227:381-388; Marks, et al. (1991) J. Mol. Biol. 222:581-597) or human monoclonal antibodies (e.g., p. 77, Cole, et al. in Reisfeld and Sell (1985) Monoclonal Antibodies and Cancer Therapy Liss; and Boerner, et al. (1991) J. Immunol. 147:86-95). Similarly, human antibodies can be made by introducing human immunoglobulin loci into transgenic animals, e.g., mice in which the endogenous immunoglobulin genes have been partially or completely inactivated. Upon challenge, human antibody production is observed, which closely resembles that seen in humans in nearly all respects, including gene reanangement, assembly, and antibody repertoire. This approach is described, e.g., in U.S. Patent Nos. 5,545,807; 5,545,806; 5,569,825; 5,625,126; 5,633,425; 5,661,016, and in the following scientific publications: Marks, et al. (1992) Bio/Technology 10:779-783; Lonberg, et al. (1994) Nature 368:856-859; Morrison (1994) Nature 368:812-13; Fishwild, et al. (1996) Nature Biotechnology 14:845-851; Neuberger (1996) Nature Biotechnolo y 14:826; and Lonberg and Huszar (1995) Intern. Rev. Immunol. 13:65-93. By immunotherapy is meant treatment of cancer with an antibody raised against cancer proteins. As used herein, immunotherapy can be passive or active. Passive immunotherapy as defined herein is the passive transfer of antibody to a recipient (patient). Active immunization is the induction of antibody and/or T-cell responses in a recipient (patient). Induction of an immune response is the result of providing the recipient with an antigen to which antibodies are raised. The antigen may be provided by injecting a polypeptide against which antibodies are desired to be raised into a recipient, or contacting the recipient with a nucleic acid capable of expressing the antigen and under conditions for expression of the antigen, leading to an immune response.
In a prefened embodiment the cancer proteins against which antibodies are raised are secreted proteins as described above. Without being bound by theory, antibodies used for treatment may bind and prevent the secreted protein from binding to its receptor, thereby inactivating the secreted cancer protein, e.g., in autocrine signaling.
In another prefened embodiment, the cancer protein to which antibodies are raised is a transmembrane protein. Without being bound by theory, antibodies used for treatment may bind the extracellular domain of the cancer protein and prevent it from binding to other proteins, such as circulating ligands or cell-associated molecules. The antibody may cause down- regulation of the transmembrane cancer protein. The antibody may be a competitive, non- competitive or uncompetitive inhibitor of protein binding to the extracellular domain of the cancer protein. The antibody may also be an antagonist of the cancer protein. Further, the antibody may prevent activation of the transmembrane cancer protein, or may induce or suppress a particular cellular pathway. In one aspect, when the antibody prevents the binding of other molecules to the cancer protein, the antibody prevents growth of the cell. The antibody may also be used to target or sensitize the cell to cytotoxic agents, including, but not limited to TNF-α, TNF-β, IL-1, INF-γ, and IL-2, or chemotherapeutic agents including 5FU, vinblastine, actinomycin D, cisplatin, methotrexate, and the like. In some instances the antibody may belong to a sub-type that activates serum complement when complexed with the transmembrane protein thereby mediating cytotoxicity or antigen-dependent cytotoxicity (ADCC). Thus, cancer may be treated by administering to a patient antibodies directed against the transmembrane cancer protein. Antibody-labeling may activate a co-toxin, localize a toxin payload, or otherwise provide means to locally ablate cells.
In another prefened embodiment, the antibody is conjugated to an effector moiety. The effector moiety can be various molecules, including labeling moieties such as radioactive labels or fluorescent labels, or can be a therapeutic moiety. In one aspect the therapeutic moiety is a small molecule that modulates the activity of a cancer protein. In another aspect the therapeutic moiety may modulate the activity of molecules associated with or in close proximity to a cancer protein. The therapeutic moiety may inhibit enzymatic or signaling activity such as protease or collagenase or protein kinase activity associated with cancer, or be an attractant of other cells, such as NK cells.
In a prefened embodiment, the therapeutic moiety can also be a cytotoxic agent. In this method, targeting the cytotoxic agent to cancer tissue or cells results in a reduction in the number of afflicted cells, thereby reducing symptoms associated with cancer. Cytotoxic agents are numerous and varied and include, but are not limited to, cytotoxic drugs or toxins or active fragments of such toxins. Suitable toxins and their conesponding fragments include diphtheria A chain, exotoxin A chain, ricin A chain, abrin A chain, curcin, crotin, phenomycin, enomycin, saporin, auristatin, and the like. Cytotoxic agents also include radiochemicals made by conjugating radioisotopes to antibodies raised against cancer proteins, or binding of a radionuclide to a chelating agent that has been covalently attached to the antibody. Targeting the therapeutic moiety to transmembrane cancer proteins not only serves to increase the local concentration of therapeutic moiety in the cancer afflicted area, but also serves to reduce deleterious side effects that may be associated with the untargeted therapeutic moiety.
In another prefened embodiment, the cancer protein against which the antibodies are raised is an intracellular protein. In this case, the antibody may be conjugated to a protein which facilitates entry into the cell. In one case, the antibody enters the cell by endocytosis. In another embodiment, a nucleic acid encoding the antibody is administered to the individual or cell. Moreover, wherein the cancer protein can be targeted within a cell, e.g., the nucleus, an antibody thereto may contain a signal for that target localization, e.g., a nuclear localization signal. The cancer antibodies of the invention specifically bind to cancer proteins. By
"specifically bind" herein is meant that the antibodies bind to the protein with a K^ of at least about 0.1 mM, more usually at least about 1 μM, preferably at least about 0.1 μM or better, and most preferably, 0.01 μM or better. Selectivity of binding to the specific target and not to related sequences is often also important. Detection of cancer sequence for diagnostic and therapeutic applications
In one aspect, the RNA expression levels of genes are determined for different cellular states in the cancer phenotype. Expression levels of genes in normal tissue (e.g., not undergoing cancer) and in cancer tissue (and in some cases, for varying severities of cancer that relate to prognosis, as outlined below), or in non-malignant disease are evaluated to provide expression profiles. A gene expression profile of a particular cell state or point of development is essentially a "fingeφrint" of the state of the cell. While two states may have a particular gene similarly expressed, the evaluation of a number of genes simultaneously allows the generation of a gene expression profile that is reflective of the state of the cell. By comparing expression profiles of cells in different states, information regarding which genes are important (including both up- and down-regulation of genes) in each of these states is obtained. Then, diagnosis may be performed or confirmed to determine whether a tissue sample has the gene expression profile of normal or cancerous tissue. This will provide for molecular diagnosis of related conditions.
"Differential expression," or grammatical equivalents as used herein, refers to qualitative or quantitative differences in the temporal and/or cellular gene expression patterns within and among cells and tissue. Thus, a differentially expressed gene can qualitatively have its expression altered, including an activation or inactivation, in, e.g., normal versus cancer tissue. Genes may be turned on or turned off in a particular state, relative to another state thus permitting comparison of two or more states. A qualitatively regulated gene will exhibit an expression pattern within a state or cell type which is detectable by standard techniques. Some genes will be expressed in one state or cell type, but not in both. Alternatively, the difference in expression may be quantitative, e.g., in that expression is increased or decreased; e.g., gene expression is either upregulated, resulting in an increased amount of transcript, or downregulated, resulting in a decreased amount of transcript. The degree to which expression differs need only be large enough to quantify via standard characterization techniques as outlined below, such as by use of Affymetrix GeneChip™ expression anays. See, Lockhart (1996) Nature Biotechnology 14:1675-1680. Other techniques include, but are not limited to, quantitative reverse transcriptase PCR, northern analysis, and RNase protection. As outlined above, preferably the change in expression (e.g., upregulation or downregulation) is at least about 50%, more preferably at least about 100%, more preferably at least about 150%, more preferably at least about 200%, with from 300 to at least 1000% being especially prefened. Evaluation may be at the gene transcript or the protein level. The amount of gene expression may be monitored using nucleic acid probes to the RNA or DNA equivalent of the gene transcript, and the quantification of gene expression levels, or, alternatively, the final gene product itself (protein) can be monitored, e.g., with antibodies to the cancer protein and standard immunoassays (ELIS As, etc.) or other techniques, including mass spectroscopy assays, 2D gel electrophoresis assays, etc. Proteins conesponding to cancer genes, e.g., those identified as being important in a cancer or disease phenotype, can be evaluated in a cancer diagnostic test. In a prefened embodiment, gene expression monitoring is performed simultaneously on a number of genes. Multiple protein expression monitoring can be performed as well.
In this embodiment, the cancer nucleic acid probes are attached to biochips as outlined herein for the detection and quantification of cancer sequences in a particular cell. The assays are further described below in the example. PCR techniques can be used to provide greater sensitivity.
In a prefened embodiment nucleic acids encoding the cancer protein are detected. Although DNA or RNA encoding the cancer protein may be detected, of particular interest are methods wherein an mRNA encoding a cancer protein is detected. Probes to detect mRNA can be a nucleotide/deoxynucleotide probe that is complementary to and hybridizes with the mRNA and includes, but is not limited to, oligonucleotides, cDNA, or RNA. Probes also should contain a detectable label, as defined herein. In one method the mRNA is detected after immobilizing the nucleic acid to be examined on a solid support such as nylon membranes and hybridizing the probe with the sample. Following washing to remove the non-specifically bound probe, the label is detected. In another method, detection of the mRNA is performed in situ. In this method permeabilized cells or tissue samples are contacted with a detectably labeled nucleic acid probe for sufficient time to allow the probe to hybridize with the target mRNA. Following washing to remove the non-specifically bound probe, the label is detected. For example a digoxygenin labeled riboprobe (RNA probe) that is complementary to the mRNA encoding a cancer protein is detected by binding the digoxygenin with an anti-digoxygenin secondary antibody and developed with nitro blue tetrazolium and 5-bromo-4-chloro-3-indoyl phosphate.
In a prefened embodiment, various proteins from the three classes of proteins as described herein (secreted, transmembrane, or intracellular proteins) are used in diagnostic assays. The cancer proteins, antibodies, nucleic acids, modified proteins, and cells containing cancer sequences are used in diagnostic assays. This can be performed on an individual gene or conesponding polypeptide level. In a prefened embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes and/or conesponding polypeptides.
As described and defined herein, cancer proteins, including intracellular, transmembrane, or secreted proteins, find use as markers of cancer, e.g., for prognostic or diagnostic pmrposes. Detection of these proteins in putative cancer tissue allows for detection, prognosis, or diagnosis of cancer or similar disease, and for selection of therapeutic strategy. In one embodiment, antibodies are used to detect cancer proteins. A prefened method separates proteins from a sample by electrophoresis on a gel (typically a denaturing and reducing protein gel, but may be another type of gel, including isoelectric focusing gels and the like). Following separation of proteins, the cancer protein is detected, e.g., by immunoblotting with antibodies raised against the cancer protein.
In another prefened method, antibodies to the cancer protein find use in in situ imaging techniques, e.g., in histology. See, e.g., Asai, et al. (eds. 1993) Methods in Cell Biology: Antibodies in Cell Biology (vol. 37) Academic Press. In this method, cells are contacted with from one to many antibodies to the cancer protein(s). Following washing to remove nonspecific antibody binding, the presence of the antibody or antibodies is detected. In one embodiment the antibody is detected by incubating with a secondary antibody that contains a detectable label. In another method the primary antibody to the cancer protein(s) contains a detectable label, e.g., an enzyme marker that can act on a substrate. In another prefened embodiment each one of multiple primary antibodies contains a distinct and detectable label. This method finds particular use in simultaneous screening for a plurality of cancer proteins. Many other histological imaging techniques are also provided by the invention.
In a prefened embodiment the label is detected in a fluorometer which has the ability to detect and distinguish emissions of different wavelengths. In addition, a fluorescence activated cell sorter (FACS) can be used in the method.
In another prefened embodiment, antibodies find use in diagnosing cancer from blood, serum, plasma, stool, and other samples. Such samples, therefore, are useful as samples to be probed or tested for the presence of cancer proteins. Antibodies can be used to detect a cancer protein by previously described immunoassay techniques including ELISA, immunoblotting (western blotting), immunoprecipitation, BIACORE technology and the like. Conversely, the presence of antibodies may indicate an immune response against an endogenous cancer protein. In a prefened embodiment, in situ hybridization of labeled cancer nucleic acid probes to tissue anays is done. For example, anays of tissue samples, including cancer tissue and/or normal tissue, are made. In situ hybridization (see, e.g., Ausubel, supra) is then performed. When comparing the fmgeφrints between an individual and a standard, a diagnosis, a prognosis, or a prediction may be based on the findings. It is further understood that the genes which indicate the diagnosis may differ from those which indicate the prognosis and molecular profiling of the condition of the cells may lead to distinctions between responsive or refractory conditions or may be predictive of outcomes.
In a prefened embodiment, the cancer proteins, antibodies, nucleic acids, modified proteins, and cells containing cancer sequences are used in prognosis assays. As above, gene expression profiles can be generated that conelate to cancer, clinical, pathological, or other information, in terms of long term prognosis. Again, this may be done on either a protein or gene level, with the use of genes being prefened. Single or multiple genes may be useful in various combinations. As above, cancer probes may be attached to biochips for the detection and quantification of cancer sequences in a tissue or patient. The assays proceed as outlined above for diagnosis. PCR method may provide more sensitive and accurate quantification. Assays for therapeutic compounds
In a prefened embodiment, the proteins, nucleic acids, and antibodies as described herein are used in drug screening assays. The cancer proteins, antibodies, nucleic acids, modified proteins, and cells containing cancer sequences are used in drug screening assays or by evaluating the effect of drug candidates on a "gene expression profile" or expression profile of polypeptides. In a prefened embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques, to allow monitoring for expression profile genes after treatment with a candidate agent (e.g., Zlokarnik, et al. (1998) Science 279:84-88; Heid (1996) Genome Res. 6:986-994. In a prefened embodiment, the cancer proteins, antibodies, nucleic acids, modified proteins and cells containing the native or modified cancer proteins are used in screening assays. That is, the present invention provides novel methods for screening for compositions which modulate the cancer phenotype or an identified physiological function of a cancer protein. As above, this can be done on an individual gene level or by evaluating the effect of drug candidates on a "gene expression profile". In a prefened embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques, to allow monitoring for expression profile genes after treatment with a candidate agent, see Zlokarnik, supra.
Having identified the differentially expressed genes herein, a variety of assays may be performed. In a prefened embodiment, assays may be nm on an individual gene or protein level. That is, having identified a particular gene as up regulated in cancer, test compounds can be screened for the ability to modulate gene expression or for binding to the cancer protein. "Modulation" thus includes both an increase and a decrease in gene expression. The prefened amount of modulation will depend on the original change of the gene expression in normal versus tissue undergoing cancer, with changes of at least 10%, preferably 50%, more preferably 100-300%, and in some embodiments 300-1000% or greater. Thus, if a gene exhibits a 4-fold increase in cancer tissue compared to normal tissue, a decrease of about four-fold is often desired; similarly, a 10-fold decrease in cancer tissue compared to normal tissue often provides a target value of a 10-fold increase in expression to be induced by the test compound. The amount of gene expression may be monitored using nucleic acid probes and the quantification of gene expression levels, or, alternatively, the gene product itself can be monitored, e.g., through the use of antibodies to the cancer protein and standard immunoassays. Proteomics and separation techniques may also allow quantification of expression.
In a prefened embodiment, gene expression or protein monitoring of a number of entities, e.g., an expression profile, is monitored simultaneously. Such profiles will typically involve a plurality of those entities described herein.
In this embodiment, the cancer nucleic acid probes are attached to biochips as outlined herein for the detection and quantification of cancer sequences in a particular cell. Alternatively, PCR may be used. Thus, a series, e.g., of microtiter plate, may be used with dispensed primers in desired wells. A PCR reaction can then be performed and analyzed for each well.
Modulators of cancer
Expression monitoring can be performed to identify compounds that modify the expression of one or more cancer-associated sequences, e.g., a polynucleotide sequence set out in the tables. Generally, in a prefened embodiment, a test modulator is added to the cells prior to analysis. Moreover, screens are also provided to identify agents that modulate cancer, modulate cancer proteins, bind to a cancer protein, or interfere with the binding of a cancer protein and an antibody or other binding partner.
The term "test compound" or "drug candidate" or "modulator" or grammatical equivalents as used herein describes a molecule, e.g., protein, oligopeptide, small organic molecule, polysaccharide, polynucleotide, etc., to be tested for the capacity to directly or indirectly alter the cancer phenotype or the expression of a cancer sequence, e.g., a nucleic acid or protein sequence. In prefened embodiments, modulators alter expression profiles, or expression profile nucleic acids or protems provided herein. In one embodiment, the modulator suppresses a cancer phenotype, e.g., to a normal or non-malignant tissue fmgeφrint. In another embodiment, a modulator induced a cancer phenotype. Generally, a plurality of assay mixtures are run in parallel with different agent concentrations to obtain a differential response to the various concentrations. Typically, one of these concentrations serves as a negative control, e.g., at zero concentration or below the level of detection. Drug candidates encompass numerous chemical classes, though typically they are organic molecules, preferably small organic compounds having a molecular weight of more than 100 and less than about 2,500 daltons. Prefened small molecules are less than 2000, or less than 1500, or less than 1000, or less than 500 D. Candidate agents comprise functional groups necessary for structural interaction with proteins, particularly hydrogen bonding, and typically include at least an amine, carbonyl, hydroxyl or carboxyl group, preferably at least two of the functional chemical groups. The candidate agents often comprise cyclical carbon or heterocyclic structures and/or aromatic or polyaromatic structures substituted with one or more of the above functional groups. Candidate agents are also found among biomolecules including peptides, saccharides, fatty acids, steroids, purines, pyrimidines, derivatives, structural analogs, or combinations thereof. Particularly prefened are peptides.
In one aspect, a modulator will neutralize the effect of a cancer protein. By "neutralize" is meant that activity of a protein is inhibited or blocked and the consequent effect on the cell. In certain embodiments, combinatorial libraries of potential modulators will be screened for an ability to bind to a cancer polypeptide or to modulate activity. Conventionally, new chemical entities with useful properties are generated by identifying a chemical compound (called a "lead compound") with some desirable property or activity, e.g., inhibiting activity, creating variants of the lead compound, and evaluating the property and activity of those variant compounds. Often, high throughput screening (HTS) methods are employed for such an analysis. See, e.g., Janzen (2002) High Throughput Screening: Methods and Protocols Humana; Devlin (ed. 1997) High Throughput Screening: The Discovery of Bioactive Substances Dekker; and Mei and Czarnik (eds. 2002) Integrated Drug Discovery Techniques Dekker.
In one prefened embodiment, high throughput screening methods involve providing a library containing a large number of potential therapeutic compounds (candidate compounds). Such "combinatorial chemical libraries" are then screened in one or more assays to identify those library members (particular chemical species or subclasses) that display a desired characteristic activity. The compounds thus identified can serve as conventional "lead compounds" or can themselves be used as potential or actual therapeutics.
A combinatorial chemical library is a collection of diverse chemical compounds generated by either chemical synthesis or biological synthesis by combining a number of chemical "building blocks" such as reagents. For example, a linear combinatorial chemical library, such as a polypeptide (e.g., mutein) library, is formed by combining a set of chemical building blocks called amino acids in every possible way for a given compound length (e.g., the number of amino acids in a polypeptide compound). Millions of chemical compounds can be synthesized through such combinatorial mixing of chemical building blocks (Gallop, et al. (1994) J. Med. Chem. 37:1233-1251).
Preparation and screening of combinatorial chemical libraries is well known. Such combinatorial chemical libraries include, but are not limited to, peptide libraries (see, e.g., U.S. Patent No. 5,010,175, Furka (1991) Pept. Prot. Res. 37:487-493, Houghton, et al. (1991) Nature 354:84-88), peptoids (PCT Publication No WO 91/19735), encoded peptides (PCT Publication WO 93/20242), random bio-oligomers (PCT Publication WO 92/00091), benzodiazepines (U.S. Pat. No. 5,288,514), diversomers such as hydantoins, benzodiazepines and dipeptides (Hobbs, et al. (1993) Proc. Nat. Acad. Sci. USA 90:6909-6913, vinylogous polypeptides (Hagihara, et al. (1992) J. Amer. Chem. Soc. 114:6568-570), nonpeptidal peptidomimetics with a Beta-D- Glucose scaffolding (Hirschmann, et al. (1992) J. Amer. Chem. Soc. 114:9217-9218), analogous organic syntheses of small compound libraries (Chen, et al. (1994) J. Amer. Chem. Soc. 116:2661-662), oligocarbamates (Cho, et al. (1993) Science 261:1303-1305), and/or peptidyl phosphonates (Campbell, et al. (1994) J. Org. Chem. 59:658-xxx). See, generally, Gordon, et al. (1994) J. Med. Chem. 37:1385-1401, nucleic acid libraries (see, e.g., Stratagene, Coφ.), peptide nucleic acid libraries (see, e.g., U.S. Patent 5,539,083), antibody libraries (see, e.g., Vaughn, et al. (1996) Nature Biotechnology 14(3):309-314, and PCT/US96/10287), carbohydrate libraries (see, e.g., Liang, et al. (1996) Science 274:1520-1522, and U.S. Patent No. 5,593,853), and small organic molecule libraries (see, e.g., benzodiazepines, page 33 Baum (Jan 18, 1993) C&EN; isoprenoids, U.S. Patent No. 5,569,588; thiazolidinones and metathiazanones, U.S. Patent No. 5,549,974; pynolidines, U.S. Patent Nos. 5,525,735 and 5,519,134; moφholino compounds, U.S. Patent No. 5,506,337; benzodiazepines, U.S. Patent No. 5,288,514; and the like).
Devices for the preparation of combinatorial libraries are commercially available (see, e.g., 357 MPS, 390 MPS, Advanced Chem Tech, Louisville KY, Symphony, Rainin, Woburn, MA, 433A Applied Biosystems, Foster City, CA, 9050 Plus, Millipore, Bedford, MA).
A number of well known robotic systems have also been developed for solution phase chemistries. These systems include automated workstations like the automated synthesis apparatus developed by Takeda Chemical Industries, LTD. (Osaka, Japan) and many robotic systems utilizing robotic arms (Zymate II, Zymark Coφoration, Hopkinton, Mass.; Orca,
Hewlett-Packard, Palo Alto, Calif), which mimic the manual synthetic operations performed by a chemist. The above devices are suitable for use with the present invention. The nature and implementation of modifications to these devices (if any) so that they can operate as discussed herein will be apparent. In addition, numerous combinatorial libraries are themselves commercially available (see, e.g., ComGenex, Princeton, N.J., Asinex, Moscow, Ru, Tripos, Inc., St. Louis, MO, ChemStar, Ltd, Moscow, RU, 3D Pharmaceuticals, Exton, PA, Martek Biosciences, Columbia, MD, etc.).
The assays to identify modulators are amenable to high throughput screening. Prefened assays thus detect enhancement or inhibition of cancer gene transcription, inhibition, or enhancement of polypeptide expression, and inhibition or enhancement of polypeptide activity. High throughput assays for the presence, absence, quantification, or other properties of particular nucleic acids or protein products are well known. Similarly, binding assays and reporter gene assays are similarly well known. Thus, e.g., U.S. Patent No. 5,559,410 discloses high throughput screening methods for proteins, U.S. Patent No. 5,585,639 discloses high throughput screening methods for nucleic acid binding (e.g., in anays), while U.S. Patent Nos. 5,576,220 and 5,541,061 disclose high throughput methods of screening for ligand/antibody binding.
In addition, high throughput screening systems are commercially available (see, e.g., Zymark Coφ., Hopkinton, MA; Air Technical Industries, Mentor, OH; Beckman Instruments, Inc. Fullerton, CA; Precision Systems, Inc., Natick, MA, etc.). These systems typically automate entire procedures, including sample and reagent pipetting, liquid dispensing, timed incubations, and final readings of the microplate in detector(s) appropriate for the assay. These configurable systems provide high throughput and rapid start up as well as a high degree~of flexibility and customization. The manufacturers of such systems provide detailed protocols for various high throughput systems. Thus, e.g., Zymark Coφ. provides technical bulletins describing screening systems for detecting the modulation of gene transcription, ligand binding, and the like.
In one embodiment, modulators are proteins, often naturally occurring proteins or fragments of naturally occurring proteins. Thus, e.g., cellular extracts containing proteins, or random or directed digests of proteinaceous cellular extracts, may be used. In this way libraries of proteins may be made for screening in the methods of the invention. Particularly prefened in this embodiment are libraries of bacterial, fungal, viral, and mammalian proteins, with the latter being prefened, and human proteins being especially prefened. Particularly useful test compound will be directed to the class of proteins to which the target belongs, e.g., substrates for enzymes or ligands and receptors.
In a prefened embodiment, modulators are peptides of from about 5-30 amino acids, with from about 5-20 amino acids being prefened, and from about 7-15 being particularly prefened. The peptides may be digests of naturally occurring proteins, random peptides, or "biased" random peptides. By "randomized" or grammatical equivalents herein is meant that each nucleic acid and peptide consists of essentially random nucleotides and amino acids, respectively. Since generally these random peptides (or nucleic acids, discussed below) are chemically synthesized, they may incoφorate a nucleotide or amino acid at any position. The synthetic process can be designed to generate randomized proteins or nucleic acids, to allow the formation of all or most of the possible combinations over the length of the sequence, thus forming a library of randomized candidate bioactive proteinaceous agents.
In one embodiment, the library is fully randomized, with no sequence preferences or constants at any position. In a prefened embodiment, the library is biased. That is, some positions within the sequence are either held constant, or are selected from a limited number of possibilities. For example, in a prefened embodiment, the nucleotides or amino acid residues are randomized within a defined class, e.g., of hydrophobic amino acids, hydrophilic residues, sterically biased (either small or large) residues, towards the creation of nucleic acid binding domains, the creation of cysteines, for cross-linking, prolines for SH-3 domains, serines, threonines, tyrosines, or histidines for phosphorylation sites, etc., or to purines, etc. Modulators of cancer can also be nucleic acids, as defined above. As described above generally for proteins, nucleic acid modulating agents may be naturally occurring nucleic acids, random nucleic acids, or "biased" random nucleic acids. For example, digests of prokaryotic or eukaryotic genomes may be used as is outlined above for proteins.
In a prefened embodiment, the candidate compounds are organic chemical moieties, a wide variety of which are available in the literature.
After the candidate agent has been added and the cells allowed to incubate for some period of time, the sample containing a target sequence to be analyzed is added to the biochip. If required, the target sequence is prepared using known techniques. For example, the sample may be treated to lyse the cells, using known lysis buffers, electroporation, etc., with purification and/or amplification such as PCR performed as appropriate. For example, an in vitro transcription with labels covalently attached to the nucleotides is performed. Generally, the nucleic acids are labeled with biotin-FITC or PE, or with cy3 or cy5.
In a prefened embodiment, the target sequence is labeled with, e.g., a fluorescent, a chemiluminescent, a chemical, or a radioactive signal, to provide a means of detecting the target sequence's specific binding to a probe. The label also can be an enzyme, such as, alkaline phosphatase or horseradish peroxidase, which when provided with an appropriate substrate produces a product that can be detected. Alternatively, the label can be a labeled compound or small molecule, such as an enzyme inhibitor, that binds but is not catalyzed or altered by the enzyme. The label also can be a moiety or compound, such as, an epitope tag or biotin which specifically binds to streptavidin. For the example of biotin, the streptavidin is labeled as described above, thereby, providing a detectable signal for the bound target sequence. Unbound labeled streptavidin is typically removed prior to analysis.
These assays can be direct hybridization assays or can comprise "sandwich assays", which include the use of multiple probes, as is generally outlined in U.S. Patent Nos. 5,681,702, 5,597,909, 5,545,730, 5,594,117, 5,591,584, 5,571,670, 5,580,731, 5,571,670, 5,591,584,
5,624,802, 5,635,352, 5,594,118, 5,359,100, 5,124,246, and 5,681,697, all of which are hereby incoφorated by reference. In this embodiment, in general, the target nucleic acid is prepared as outlined above, and then added to the biochip comprising a plurality of nucleic acid probes, under conditions that allow the formation of a hybridization complex. A variety of hybridization conditions may be used in the present invention, including high, moderate, and low stringency conditions as outlined above. The assays are generally run under stringency conditions which allows formation of the label probe hybridization complex only in the presence of target. Stringency can be controlled by altering a step parameter that is a thermodynamic variable, including, but not limited to, temperature, formamide concentration, salt concentration, chaotropic salt concentration, pH, organic solvent concentration, etc.
These parameters may also be used to control non-specific binding, as is generally outlined in U.S. Patent No. 5,681,697. Thus it may be desirable to perform certain steps at higher stringency conditions to reduce non-specific binding.
The reactions outlined herein may be accomplished in a variety of ways. Components of the reaction may be added simultaneously, or sequentially, in different orders, with prefened embodiments outlined below. In addition, the reaction may include a variety of other reagents. These include salts, buffers, neutral proteins, e.g., albumin, detergents, etc. which may be used to facilitate optimal hybridization and detection, and/or reduce non-specific or background interactions. Reagents that otherwise improve the efficiency of the assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., may also be used as appropriate, depending on the sample preparation methods and purity of the target. The assay data are analyzed to determine the expression levels, and changes in expression levels as between states of individual genes, forming a gene expression profile.
Screens are performed to identify modulators of the cancer phenotype. In one embodiment, screening is performed to identify modulators that can induce or suppress a particular expression profile, thus preferably generating the associated phenotype. In another embodiment, e.g., for diagnostic applications, having identified differentially expressed genes important in a particular state, screens can be performed to identify modulators that alter expression of individual genes. In an another embodiment, screening is performed to identify modulators that alter a biological function of the expression product of a differentially expressed gene. Again, having identified the importance of a gene in a particular state, screens are performed to identify agents that bind and/or modulate the biological activity of the gene product.
In addition, screens can be done for genes that are induced in response to a candidate agent or treatment process. After identifying a modulator based upon its ability to suppress a cancer expression pattern leading to a normal expression pattern (or its converse), or to modulate a single cancer gene expression profile so as to mimic the expression of the gene from normal tissue, a screen as described above can be performed to identify genes that are specifically modulated in response to the agent. Comparing expression profiles between normal tissue and agent treated cancer tissue reveals genes that are not expressed in normal tissue or cancer tissue, but are expressed in agent treated tissue. These agent-specific sequences can be identified and used by methods described herein for cancer genes or proteins. In particular, these sequences and the proteins they encode find use in marking or identifying agent treated cells. In addition, antibodies can be raised against the agent induced proteins and used to target novel therapeutics to the treated cancer tissue sample.
Thus, in one embodiment, a test compound is administered to a population of cancer cells that have an associated cancer expression profile. By "administration" or "contacting" herein is meant that the candidate agent is added to the cells in such a manner as to allow the agent to act upon the cell, whether by uptake and intracellular action, or by action at the cell surface. In some embodiments, nucleic acid encoding a proteinaceous candidate agent (e.g., a peptide) may be put into a viral construct such as an adenoviral or retroviral construct, and added to the cell, such that expression of the peptide agent is accomplished, e.g., PCT US97/01019. Regulatable gene therapy systems can also be used. Once a test compound has been administered to the cells, the cells can be washed if desired and are allowed to incubate under preferably physiological conditions for some period of time. The cells are then harvested and a new gene expression profile is generated, as outlined herein.
Thus, e.g., cancer or non-malignant tissue may be screened for agents that modulate, e.g., induce or suppress a cancer phenotype. A change in at least one gene, preferably many, of the expression profile indicates that the agent has an effect on cancer activity. By defining such a signature for the cancer phenotype, screens for new drugs that alter the phenotype can be devised. With this approach, the drug target need not be known and need not be represented in the original expression screening platform, nor does the level of transcript for the target protein need to change.
In a prefened embodiment, as outlined above, screens may be done on individual genes and gene products (proteins). That is, having identified a particular differentially expressed gene as important in a particular state, screening of modulators of either the expression of the gene or the gene product itself can be done. The gene products of differentially expressed genes are sometimes refened to herein as "cancer proteins" or a "cancer modulatory protein". The cancer modulatory protein may be a fragment, or alternatively, be the full length protein to the fragment encoded by the nucleic acids of the Tables. Preferably, the cancer modulatory protein is a fragment. In a prefened embodiment, the cancer amino acid sequence which is used to determine sequence identity or similarity is encoded by a nucleic acid of the Tables. In another embodiment, the sequences are naturally occurring allelic variants of a protein encoded by a nucleic acid of the Tables. In another embodiment, the sequences are sequence variants as further described herein.
Preferably, the cancer modulatory protein is a fragment of about 14-24 amino acids long. More preferably the fragment is a soluble fragment. Preferably, the fragment includes a non-transmembrane region. In a prefened embodiment, the fragment has an N-terminal Cys to aid in solubility. In one embodiment, the C-terminus of the fragment is kept as a free acid and the N-terminus is a free amine to aid in coupling, e.g., to cysteine. In one embodiment the cancer proteins are conjugated to an immunogenic agent as discussed herein. In one embodiment the cancer protein is conjugated to BSA.
Measurements of cancer polypeptide activity, or of cancer or the cancer phenotype can be performed using a variety of assays. For example, the effects of the test compounds upon the function of the cancer polypeptides can be measured by examining parameters described above. A suitable physiological change that affects activity can be used to assess the influence of a test compound on the polypeptides of this invention. When the functional consequences are determined using intact cells or animals, one can also measure a variety of effects such as, in the case of cancer associated with tumors, tumor growth, tumor metastasis, neovascularization, hormone release, transcriptional changes to both known and uncharacterized genetic markers (e.g., northern blots), changes in cell metabolism such as cell growth or pH changes, and changes in intracellular second messengers such as cGMP. In the assays of the invention, mammalian cancer polypeptide is typically used, e.g., mouse, preferably human.
Assays to identify compounds with modulating activity can be performed in vitro. For example, a cancer polypeptide is first contacted with a potential modulator and incubated for a suitable amount of time, e.g., from 0.5-48 hours. In one embodiment, the cancer polypeptide levels are determined in vitro by measuring the level of protein or mRNA. The level of protein is typically measured using immunoassays such as western blotting, ELISA, and the like with an antibody that selectively binds to the cancer polypeptide or a fragment thereof. For measurement of mRNA, amplification, e.g., using PCR, LCR, or hybridization assays, e.g., northern hybridization, RNAse protection, dot blotting, are prefened. The level of protein or mRNA is typically detected using directly or indirectly labeled detection agents, e.g., fluorescently or radioactively labeled nucleic acids, radioactively or enzymatically labeled antibodies, and the like, as described herein. Alternatively, a reporter gene system can be devised using a cancer protein promoter operably linked to a reporter gene such as luciferase, green fluorescent protein, CAT, or -gal. The reporter construct is typically transfected into a cell. After treatment with a potential modulator, the amount of reporter gene transcription, translation, or activity is measured according to standard techniques. In a prefened embodiment, as outlined above, screens may be done on individual genes and gene products (proteins). That is, having identified a particular differentially expressed gene as important in a particular state, screening of modulators of the expression of the gene or the gene product itself can be done. The gene products of differentially expressed genes are sometimes refened to herein as "cancer proteins." The cancer protein may be a fragment, or alternatively, the full length protein to a fragment shown herein.
In one embodiment, screening for modulators of expression of specific genes is performed. Typically, the expression of only one or a few genes are evaluated. In another embodiment, screens are designed to first find compounds that bind to differentially expressed proteins. These compounds are then evaluated for the ability to modulate differentially expressed activity. Moreover, once initial candidate compounds are identified, variants can be further screened to better evaluate structure activity relationships. In a prefened embodiment, binding assays are done. In general, purified or isolated gene product is used; that is, the gene products of one or more differentially expressed nucleic acids are made. For example, antibodies are generated to the protein gene products, and standard immunoassays are run to determine the amount of protein present. Alternatively, cells comprising the cancer proteins can be used in the assays. Thus, in a prefened embodiment, the methods comprise combining a cancer protein and a candidate compound, and determining the binding of the compound to the cancer protein. Prefened embodiments utilize the human cancer protein, although other mammalian proteins may also be used, e.g., for the development of animal models of human disease. In some embodiments, as outlined herein, variant or derivative cancer proteins may be used. Generally, in a prefened embodiment of the methods herein, the cancer protein or the candidate agent is non-diffusably bound to an insoluble support, preferably having isolated sample receiving areas (e.g., a microtiter plate, an anay, etc.). The insoluble supports may be made of a composition to which the compositions can be bound, is readily separated from soluble material, and is otherwise compatible with the overall method of screening. The surface of such supports may be solid or porous and of a convenient shape. Examples of suitable insoluble supports include microtiter plates, anays, membranes, and beads. These are typically made of glass, plastic (e.g., polystyrene), polysaccharides, nylon or nitrocellulose, teflon™, etc. Microtiter plates and anays are especially convenient because a large number of assays can be carried out simultaneously, using small amounts of reagents and samples. The particular manner of binding of the composition is typically not crucial so long as it is compatible with the reagents and overall methods of the invention, maintains the activity of the composition, and is nondiffusable. Prefened methods of binding include the use of antibodies (which do not sterically block either the ligand binding site or activation sequence when the protein is bound to the support), direct binding to "sticky" or ionic supports, chemical crosslinking, the synthesis of the protein or agent on the surface, etc. Following binding of the protein or agent, excess unbound material is removed by washing. The sample receiving areas may then be blocked through incubation with bovine serum albumin (BSA), casein, or other innocuous protein or other moiety.
In a prefened embodiment, the cancer protein is bound to the support, and a test compound is added to the assay. Alternatively, the candidate agent is bound to the support and the cancer protein is added. Novel binding agents include specific antibodies, non-natural binding agents identified in screens of chemical libraries, peptide analogs, etc. Of particular interest are screening assays for agents that have a low toxicity for human cells. A wide variety of assays may be used for this puφose, including labeled in vitro protein-protein binding assays, electrophoretic mobility shift assays, immunoassays for protein binding, functional assays (phosphorylation assays, etc.), and the like. The determination of the binding of the test modulating compound to the cancer protein may be done in a number of ways. In a prefened embodiment, the compound is labeled, and binding determined directly, e.g., by attaching all or a portion of the cancer protein to a solid support, adding a labeled candidate agent (e.g., a fluorescent label), washing off excess reagent, and determining whether the label is present on the solid support. Various blocking and washing steps may be utilized as appropriate.
In some embodiments, only one of the components is labeled, e.g., the proteins (or proteinaceous candidate compounds) can be labeled. Alternatively, more than one component can be labeled with different labels, e.g., 125j_ for t e proteins and a fluorophor for the compound. Proximity reagents, e.g., quenching or energy transfer reagents are also useful. In one embodiment, the binding of the test compound is determined by competitive binding assay. The competitor may be a binding moiety known to bind to the target molecule (e.g., a cancer protein), such as an antibody, peptide, binding partner, ligand, etc. Under certain circumstances, there may be competitive binding between the compound and the binding moiety, with the binding moiety displacing the compound. In one embodiment, the test compound is labeled. Either the compound, or the competitor, or both, is added first to the protein for a time sufficient to allow binding, if present. Incubations may be performed at a temperature which facilitates optimal activity, typically between about 4-40° C. Incubation periods are typically optimized, e.g., to facilitate rapid high throughput screening. Typically between 0.1-1 hour will be sufficient. Excess reagent is generally removed or washed away. The second component is then added, and the presence or absence of the labeled component is followed, to indicate binding. In a prefened embodiment, the competitor is added first, followed by a test compound.
Displacement of the competitor is an indication that the test compound is binding to the cancer protein and thus is capable of binding to, and potentially modulating, the activity of the cancer protein. In this embodiment, either component can be labeled. Thus, e.g., if the competitor is labeled, the presence of label in the wash solution indicates displacement by the agent. Alternatively, if the test compound is labeled, the presence of the label on the support indicates displacement.
In an alternative embodiment, the test compound is added first, with incubation and washing, followed by the competitor. The absence of binding by the competitor may indicate that the test compound is bound to the cancer protein with a higher affinity. Thus, if the test compound is labeled, the presence of the label on the support, coupled with a lack of competitor binding, may indicate that the test compound is capable of binding to the cancer protein.
In a prefened embodiment, the methods comprise differential screening to identity agents that are capable of modulating the activity of the cancer proteins. In one embodiment, the methods comprise combining a cancer protein and a competitor in a first sample. A second sample comprises a test compound, a cancer protein, and a competitor. The binding of the competitor is determined for both samples, and a change, or difference in binding between the two samples indicates the presence of an agent capable of binding to the cancer protein and potentially modulating its activity. That is, if the binding of the competitor is different in the second sample relative to the first sample, the agent is capable of binding to the cancer protein. Alternatively, differential screening is used to identify drug candidates that bind to the native cancer protein, but cannot bind to modified cancer proteins. The structure of the cancer protein may be modeled, and used in rational drug design to synthesize agents that interact with that site. Drug candidates that affect the activity of a cancer protein are also identified by screening drugs for the ability to either enhance or reduce the activity of the protein. Positive controls and negative controls may be used in the assays. Preferably control and test samples are performed in at least triplicate to obtain statistically significant results. Incubation of all samples is for a time sufficient for the binding of the agent to the protein. Following incubation, samples are washed free of non-specifically bound material and the amount of bound, generally labeled agent determined. For example, where a radiolabel is employed, the samples may be counted in a scintillation counter to determine the amount of bound compound. A variety of other reagents may be included in the screening assays. These include reagents like salts, neutral proteins, e.g., albumin, detergents, etc., which may be used to facilitate optimal protein-protein binding and/or reduce non-specific or background interactions. Also reagents that otherwise improve the efficiency of the assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., maybe used. The mixture of components may be added in an order that provides for the requisite binding.
In a prefened embodiment, the invention provides methods for screening for a compound capable of modulating the activity of a cancer protein. The methods comprise adding a test compound, as defined above, to a cell comprising cancer proteins. Prefened cell types include almost any cell. The cells contain a recombinant nucleic acid that encodes a cancer protein. In a prefened embodiment, a library of candidate agents are tested on a plurality of cells.
In one aspect, the assays are evaluated in the presence or absence or previous or subsequent exposure of physiological signals, e.g., hormones, antibodies, peptides, antigens, cytokines, growth factors, action potentials, pharmacological agents including chemotherapeutics, radiation, carcinogenics, or other cells (e.g., cell-cell contacts). In another example, the determinations are determined at different stages of the cell cycle process.
In this way, compounds that modulate cancer agents are identified. Compounds with pharmacological activity are able to enhance or interfere with the activity of the cancer protein. Once identified, similar structures are evaluated to identify critical structural feature of the compound.
In one embodiment, a method of inhibiting cancer cell division is provided. The method comprises administration of a cancer inhibitor. In another embodiment, a method of inhibiting cancer is provided. The method may comprise administration of a cancer inhibitor. In a further embodiment, methods of treating cells or individuals with cancer are provided, e.g., comprising administration of a cancer inhibitor.
In one embodiment, a cancer inhibitor is an antibody as discussed above. In another embodiment, the cancer inhibitor is an antisense molecule. A variety of cell growth, proliferation, viability, and metastasis assays are available, as described below. Soft agar growth or colony formation in suspension
Normal cells require a solid substrate to attach and grow. When the cells are transformed, they lose this phenotype and grow detached from the substrate. For example, transformed cells can grow in stined suspension culture or suspended in semi-solid media, such as semi-solid or soft agar. The transformed cells, when transfected with tumor suppressor genes, regenerate normal phenotype and require a solid substrate to attach and grow. Soft agar growth or colony formation in suspension assays can be used to identify modulators of cancer sequences, which when expressed in host cells, inhibit abnormal cellular proliferation and transformation. A therapeutic compound would reduce or eliminate the host cells' ability to grow in stined suspension culture or suspended in semi-solid media, such as semi-solid or soft. Techniques for soft agar growth or colony formation in suspension assays are described, e.g., in Freshney (1998) Culture of Animal Cells: A Manual of Basic Technique (3d ed.) Wiley- Liss; Freshney (2000) Culture of Animal Cells: A Manual of Basic Technique (4th ed.) Wiley- Liss; and Garkavtsev, et al. (1996) Nature Genet. 14:415-20. Contact inhibition and density limitation of growth
Normal cells typically grow in a flat and organized pattern in a petri dish until they touch other cells. When the cells touch one another, they are contact inhibited and stop growing. When cells are transformed, however, the cells are not contact inhibited and continue to grow to high densities in disorganized foci. Thus, the transformed cells grow to a higher saturation density than normal cells. This can be detected moφhologically by the formation of a disoriented monolayer of cells or rounded cells in foci within the regular pattern of normal sunounding cells. Alternatively, labeling index with (^HHhymidine at saturation density can be used to measure density limitation of growth. See Freshney (2000), supra. The transformed cells, when transfected with tumor suppressor genes, regenerate a normal phenotype and become contact inhibited and would grow to a lower density.
In this assay, labeling index with (3H)-thymidine at saturation density is a prefened method of measuring density limitation of growth. Transformed host cells are transfected with a cancer-associated sequence and are grown for 24 hours at saturation density in non-limiting medium conditions. The percentage of cells labeling with (3H)-thymidine is determined autoradiographically. See, Freshney (1998), supra. Growth factor or serum dependence
Transformed cells typically have a lower serum dependence than their normal counteφarts (see, e.g., Temin (1966) J. Natl. Cancer Insti. 37:167-175; Eagle, et al.(1970) J.
Exp. Med. 131:836-879); Freshney, supra. This is in part due to release of various growth factors by the transformed cells. Growth factor or serum dependence of transformed host cells can be compared with that of control.
Tumor specific markers levels
Tumor cells release an increased amount of certain factors (hereinafter "tumor specific markers") than their normal counteφarts. For example, plasminogen activator (PA) is released from human glioma at a higher level than from normal brain cells (see, e.g., Gullino
"Angiogenesis, tumor vascularization, and potential interference with tumor growth" pp. 178-
184 in Mihich (ed. 1985) Biological Responses in Cancer Plenum. Similarly, tumor angiogenesis factor (TAF) is released at a higher level in tumor cells than their normal . counteφarts. See, e.g., Folkman (1992) Sem. Cancer Biol. 3:89-96. Various techniques which measure the release of these factors are described in Freshney
(1998), supra. Also, see, Unkeless, et al. (1974) J. Biol. Chem. 249:4295-4305; Strickland and
Beers (1976) J. Biol. Chem. 251:5694-5702; Whur, et al. (1980) Br. J. Cancer 42:305-312:
Gullino "Angiogenesis, tumor vascularization, and potential interference with tumor growth" pp. 178-184 in Mihich (ed. 1985) Biological Responses in Cancer Plenum; Freshney (1985) Anticancer Res. 5:111-130.
Invasiveness into Matrigel
The degree of invasiveness into Matrigel or some other extracellular matrix constituent can be used as an assay to identify compounds that modulate cancer-associated sequences.
Tumor cells exhibit a good conelation between malignancy and invasiveness of cells into Matrigel or some other extracellular matrix constituent. In this assay, tumorigenic cells are typically used as host cells. Expression of a tumor suppressor gene in these host cells would decrease invasiveness of the host cells.
Techniques described in Freshney (1994), supra, can be used. Briefly, the level of invasion of host cells can be measured by using filters coated with Matrigel or some other extracellular matrix constituent. Penetration into the gel, or through to the distal side of the filter, is rated as invasiveness, and rated histologically by number of cells and distance moved, or by prelabeling the cells with 125j and counting the radioactivity on the distal side of the filter or bottom of the dish. See, e.g., Freshney (1984), supra. Tumor growth in vivo
Effects of cancer-associated sequences on cell growth can be tested in transgenic or immune-suppressed mice. Knock-out transgenic mice can be made, in which the cancer gene is disrupted or in which a cancer gene is inserted. Knock-out transgenic mice can be made by insertion of a marker gene or other heterologous gene into the endogenous cancer gene site in the mouse genome via homologous recombination. Such mice can also be made by substituting the endogenous cancer gene with a mutated version of the cancer gene, or by mutating the endogenous cancer gene, e.g., by exposure to carcinogens.
A DNA construct is introduced into the nuclei of embryonic stem cells. Cells containing the newly engineered genetic lesion are injected into a host mouse embryo, which is reimplanted into a recipient female. Some of these embryos develop into chimeric mice that possess germ cells partially derived from the mutant cell line. Therefore, by breeding the chimeric mice it is possible to obtain a new line of mice containing the introduced genetic lesion (see, e.g., Capecchi, et al. (1989) Science 244:1288-1292). Chimeric targeted mice can be derived according to Hogan, et al. (1988) Manipulating the Mouse Embryo: A Laboratory Manual CSH Press; and Robertson (ed. 1987) Teratocarcinomas and Embryonic Stem Cells: A Practical Approach IRL Press, Washington, D.C. Alternatively, various immune-suppressed or immune-deficient host animals can be used. For example, genetically athymic "nude" mouse (see, e.g., Giovanella, et al. (1974) Natl. Cancer Inst. 52:921-930), a SCED mouse, a thymectomized mouse, or an inadiated mouse (see, e.g., Bradley, et al. (1978) Br. J. Cancer 38:263-272; Selby, et al. (1980) Br. J. Cancer
41:52-61) can be used as a host. Transplantable tumor cells (typically about 10" cells) injected into isogenic hosts will produce invasive tumors in a high proportions of cases, while normal cells of similar origin will not. In hosts which developed invasive tumors, cells expressing a cancer-associated sequences are injected subcutaneously. After a suitable length of time, preferably 4-8 weeks, tumor growth is measured (e.g., by volume or by its two largest dimensions) and compared to the control. Tumors that have statistically significant reduction (using, e.g., Student's T test) are said to have inhibited growth. Polynucleotide modulators of cancer Antisense and RNAi Polynucleotides
In certain embodiments, the activity of a cancer-associated protein is down-regulated, or entirely inhibited, by the use of an inhibitory or antisense polynucleotide, e.g., a nucleic acid complementary to, and which can preferably hybridize specifically to, a coding mRNA nucleic acid sequence, e.g., a cancer protein mRNA, or a subsequence thereof. Binding of the antisense polynucleotide to the mRNA reduces the translation and/or stability of the mRNA.
In the context of this invention, antisense polynucleotides can comprise naturally- occurring nucleotides, or synthetic species formed from naturally-occurring subunits or their close homologs. Antisense polynucleotides may also have altered sugar moieties or inter-sugar linkages. Exemplary among these are the phosphorothioate and other sulfur containing species. Analogs are comprehended by this invention so long as they function effectively to hybridize with the cancer protein mRNA. See, e.g., Isis Pharmaceuticals, Carlsbad, CA; Sequitor, Inc., Natick, MA. Such antisense polynucleotides can readily be synthesized using recombinant means, or can be synthesized in vitro. Equipment for such synthesis is sold by several vendors, including Applied Biosystems. The preparation of other oligonucleotides such as phosphorothioates and alkylated derivatives is also well known.
Antisense molecules as used herein include antisense or sense oligonucleotides. Sense oligonucleotides can, e.g., be employed to block transcription by binding to the anti-sense strand. The antisense and sense oligonucleotide comprise a single-stranded nucleic acid sequence (either RNA or DNA) capable of binding to target mRNA (sense) or DNA (antisense) sequences for cancer molecules. A prefened antisense molecule is for a cancer sequences in the Tables, or for a ligand or activator thereof. Antisense or sense oligonucleotides, according to the present invention, comprise a fragment generally at least about 14 nucleotides, preferably from about 14-30 nucleotides. The ability to derive an antisense or a sense oligonucleotide, based upon a cDNA sequence encoding a given protein is described in, e.g., Stein and Cohen (1988) Cancer Res. 48:2659-2668; and van der Krol, et al. (1988) BioTechniques 6:958-976. RNA interference is a mechanism to suppress gene expression in a sequence specific manner. See, e.g., Brumelkamp, et al. (2002) Sciencexpress (21March2002); Shaφ (1999) Genes Dev. 13:139-141; and Cathew (2001) Cun. Op. Cell Biol. 13:244-248. In mammalian cells, short, e.g., 21 nt, double stranded small interfering RNAs (siRNA) have been shown to be effective at inducing an RNAi response. See, e.g., Elbashir, et al. (2001) Nature 411 :494-498. The mechanism may be used to downregulate expression levels of identified genes, e.g., treatment of or validation of relevance to disease. Ribozymes In addition to antisense polynucleotides, ribozymes can be used to target and inhibit transcription of cancer-associated nucleotide sequences. A ribozyme is an RNA molecule that catalytically cleaves other RNA molecules. Different kinds of ribozymes have been described, including group I ribozymes, hammerhead ribozymes, haiφin ribozymes, RNase P, and axhead ribozymes (see, e.g., Castanotto, et al. (1994) Adv. in Pharmacology 25: 289-317 for a general review of the properties of different ribozymes).
The general features of haiφin ribozymes are described, e.g., in Hampel, et al. (1990) Nucl. Acids Res. 18:299-304; European Patent Publication No. 0 360 257; U.S. Patent No. 5,254,678. Methods of preparation are described in, e.g., WO 94/26877; Ojwang, et al. (1993) Proc. Natl. Acad. Sci. USA 90:6340-6344; Yamada, et al. (1994) Human Gene Therapy 1:39- 45; Leavitt, et al.(1995) Proc. Natl. Acad. Sci. USA 92:699-703; Leavitt, et al. (1994) Human Gene Therapy 5:1151-120; and Yamada, et al. (1994) Virology 205: 121-126.
Polynucleotide modulators of cancer may be introduced into a cell containing the target nucleotide sequence by formation of a conjugate with a ligand binding molecule, as described in WO 91/04753. Suitable ligand binding molecules include, but are not limited to, cell surface receptors, growth factors, other cytokines, or other ligands that bind to cell surface receptors. Preferably, conjugation of the ligand binding molecule does not substantially interfere with the ability of the ligand binding molecule to bind to its conesponding molecule or receptor, or block entry of the sense or antisense oligonucleotide or its conjugated version into the cell. Alternatively, a polynucleotide modulator of cancer may be introduced into a cell containing the target nucleic acid sequence, e.g., by formation of an polynucleotide-lipid complex, as described in WO 90/10448. It is understood that the use of antisense molecules or knock out and knock in models may also be used in screening assays as discussed above, in addition to methods of treatment.
Thus, in one embodiment, methods of modulating cancer in cells or organisms are provided. In one embodiment, the methods comprise administering to a cell an anti-cancer antibody that reduces or eliminates the biological activity of an endogenous cancer protein. Alternatively, the methods comprise administering to a cell or organism a recombinant nucleic acid encoding a cancer protein. This may be accomplished in any number of ways. In a prefened embodiment, e.g., when the cancer sequence is down-regulated in cancer, such state may be reversed by increasing the amount of cancer gene product in the cell. This can be accomplished, e.g., by overexpressing the endogenous cancer gene or administering a gene encoding the cancer sequence, using known gene-therapy techniques. In a prefened embodiment, the gene therapy techniques include the incoφoration of the exogenous gene using enhanced homologous recombination (EHR), e.g., as described in PCT/US93/0386. Alternatively, e.g., when the cancer sequence is up-regulated in cancer, the activity of the endogenous cancer gene is decreased, e.g., by the administration of a cancer antisense or other inhibitor, e.g., RNAi.
In one embodiment, the cancer proteins of the present invention may be used to generate polyclonal and monoclonal antibodies to cancer proteins. Similarly, the cancer proteins can be coupled, using standard technology, to affinity chromatography columns. These columns may then be used to purify cancer antibodies useful for production, diagnostic, or therapeutic puφoses. In a prefened embodiment, the antibodies are generated to epitopes unique to a cancer protein; that is, the antibodies show little or no cross-reactivity to other proteins. The cancer antibodies may be coupled to standard affinity chromatography columns and used to purify cancer proteins. The antibodies may also be used as blocking polypeptides, as outlined above, since they will specifically bind to the cancer protein. Methods of identifying variant cancer-associated sequences
Without being bound by theory, expression of various cancer sequences is conelated with cancer. Accordingly, disorders based on mutant or variant cancer genes may be determined. In one embodiment, the invention provides methods for identifying cells containing variant cancer genes, e.g., determining all or part of the sequence of at least one endogenous cancer gene in a cell. In a prefened embodiment, the invention provides methods of identifying the cancer genotype of an individual, e.g., determining all or part of the sequence of at least one cancer gene of the individual. This is generally done in at least one tissue of the individual, and may include the evaluation of a number of tissues or different samples of the same tissue. The method may include comparing the sequence of the sequenced cancer gene to a known cancer gene, e.g., a wild-type gene.
The sequence of all or part of the cancer gene can then be compared to the sequence of a known cancer gene to determine if any differences exist. This can be done using known homology programs, such as Bestfit, etc. In a prefened embodiment, the presence of a difference in the sequence between the cancer gene of the patient and the known cancer gene conelates with a disease state or a propensity for a disease state, as outlined herein.
In a prefened embodiment, the cancer genes are used as probes to determine the number of copies of the cancer gene in the genome.
In another prefened embodiment, the cancer genes are used as probes to determine the chromosomal localization of the cancer genes. Information such as chromosomal localization finds use in providing a diagnosis or prognosis in particular when chromosomal abnormalities such as translocations, and the like are identified in the cancer gene locus. Administration of pharmaceutical and vaccine compositions
In one embodiment, a therapeutically effective dose of a cancer protein or modulator thereof, is administered to a patient. By "therapeutically effective dose" herein is meant a dose that produces effects for which it is administered. The exact dose will depend on the puφose of the treatment, and will be ascertainable using known techniques. See, e.g., Ansel, et al. (1999) Pharmaceutical Dosage Forms and Drug Delivery Lippincott; Lieberman (1992) Pharmaceutical Dosage Forms (vols. 1-3) Dekker, ISBN 0824770846, 082476918X, 0824712692, 0824716981; Lloyd (1999) The Art, Science and Technology of Pharmaceutical Compounding Amer. Pharmaceut. Assn.; and Pickar (1998) Dosage Calculations Thomson. Adjustments for cancer degradation, systemic versus localized delivery, and rate of new protease synthesis, as well as the age, body weight, general health, sex, diet, time of administration, drug interaction and the severity of the condition may be necessary. U.S. Patent Application No. 09/687,576, further discloses the use of compositions and methods of diagnosis and treatment in cancer.
A "patient" for the puφoses of the present invention includes both humans and other animals, particularly mammals. Thus the methods are applicable to both human therapy and veterinary applications. In the prefened embodiment the patient is a mammal, preferably a primate, and in the most prefened embodiment the patient is human.
The administration of the cancer proteins and modulators thereof of the present invention can be done in a variety of ways, including, but not limited to, orally, subcutaneously, intravenously, intranasally, transdermally, intraperitoneally, intramuscularly, intrapulmonary, vaginally, rectally, or intraocularly. In some instances, e.g., in the treatment of wounds and inflammation, the cancer proteins and modulators may be directly applied as a solution or spray. The pharmaceutical compositions of the present invention comprise a cancer protein in a form suitable for administration to a patient. In the prefened embodiment, the pharmaceutical compositions are in a water soluble form, such as being present as pharmaceutically acceptable salts, which is meant to include both acid and base addition salts. "Pharmaceutically acceptable acid addition salt" refers to those salts that retain the biological effectiveness of the free bases and that are not biologically or otherwise undesirable, formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like, and organic acids such as acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, and the like. "Pharmaceutically acceptable base addition salts" include those derived from inorganic bases such as sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts, and the like. Particularly prefened are the ammonium, potassium, sodium, calcium, and magnesium salts. Salts derived from pharmaceutically acceptable organic non-toxic bases include salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine.
The pharmaceutical compositions may also include one or more of the following: carrier proteins such as serum albumin; buffers; fillers such as microcrystalline cellulose, lactose, corn and other starches; binding agents; sweeteners and other flavoring agents; coloring agents; and polyethylene glycol.
The pharmaceutical compositions can be administered in a variety of unit dosage forms depending upon the method of administration. For example, unit dosage forms suitable for oral administration include, but are not limited to, powder, tablets, pills, capsules and lozenges. It is recognized that cancer protein modulators (e.g., antibodies, antisense constructs, ribozymes, small organic molecules, etc.) when administered orally, should be protected from digestion. This is typically accomplished either by complexing the molecule(s) with a composition to render it resistant to acidic and enzymatic hydrolysis, or by packaging the molecule(s) in an appropriately resistant carrier, such as a liposome or a protection barrier. Means of protecting agents from digestion are available. The compositions for administration will commonly comprise a cancer protein modulator dissolved in a pharmaceutically acceptable carrier, preferably an aqueous carrier. A variety of aqueous carriers can be used, e.g., buffered saline and the like. These solutions are sterile and generally free of undesirable matter. These compositions maybe sterilized by conventional, well known sterilization techniques. The compositions may contain pharmaceutically acceptable auxiliary substances as required to approximate physiological conditions such as pH adjusting and buffering agents, toxicity adjusting agents, and the like, e.g., sodium acetate, sodium chloride, potassium chloride, calcium chloride, sodium lactate, and the like. The concentration of active agent in these formulations can vary widely, and will be selected primarily based on fluid volumes, viscosities, body weight, and the like in accordance with the particular mode of administration selected and the patient's needs (e.g., (1980) Remington's Pharmaceutical Science (18th ed.) Mack, and Hardman and Limbird (eds. 2001) Goodman and Gilman: The Pharmacologial Basis of Therapeutics (10th ed.) McGraw-Hill. Thus, a typical pharmaceutical composition for intravenous administration would be about 0.1 to 10 mg per patient per day. Dosages from 0.1 up to about 100 mg per patient per day may be used, particularly when the drug is administered to a secluded site and not into the blood stream, such as into a body cavity or into a lumen of an organ. Substantially higher dosages are possible in topical administration. Actual methods for preparing parenterally administrable compositions will be known or apparent. The compositions containing modulators of cancer proteins can be administered for therapeutic or prophylactic treatments. In therapeutic applications, compositions are administered to a patient suffering from a disease (e.g., a cancer) in an amount sufficient to cure or at least partially anest the disease and its complications. An amount adequate to accomplish this is defined as a "therapeutically effective dose." Amounts effective for this use will depend upon the severity of the disease and the general state of the patient's health. Single or multiple administrations of the compositions may be administered depending on the dosage and frequency as required and tolerated by the patient. In any event, the composition should provide a sufficient quantity of the agents of this invention to effectively treat the patient. An amount of modulator that is capable of preventing or slowing the development of cancer in a mammal is refened to as a "prophylactically effective dose." The particular dose required for a prophylactic treatment will depend upon the medical condition and history of the mammal, the particular cancer being prevented, as well as other factors such as age, weight, gender, administration route, efficiency, etc. Such prophylactic treatments may be used, e.g., in a mammal who has previously had cancer to prevent a recunence of the cancer, or in a mammal who is suspected of having a significant likelihood of developing cancer based, at least in part, upon gene expression profiles. Vaccine strategies may be used, in either a DNA vaccine form, or protein vaccine.
It will be appreciated that the present cancer protein-modulating compounds can be administered alone or in combination with additional cancer modulating compounds or with other therapeutic agent, e.g., other anti-cancer agents or treatments.
In numerous embodiments, one or more nucleic acids, e.g., polynucleotides comprising nucleic acid sequences set forth in the Tables, such as RNAi, antisense polynucleotides or ribozymes, will be introduced into cells, in vitro or in vivo. The present invention provides methods, reagents, vectors, and cells useful for expression of cancer-associated polypeptides and nucleic acids using in vitro (cell-free), ex vivo or in vivo (cell or organism-based) recombinant expression systems. The particular procedure used to introduce the nucleic acids into a host cell for expression of a protein or nucleic acid is application specific. Many procedures for introducing foreign nucleotide sequences into host cells may be used. These include the use of calcium phosphate transfection, spheroplasts, electroporation, liposomes, microinjection, plasma vectors, viral vectors, and other well known methods for introducing cloned genomic DNA, cDNA, synthetic DNA, or other foreign genetic material into a host cell (see, e.g., Berger and Kimmel (1987) Guide to Molecular Cloning Techniques from Methods in Enzymolo y (vol. 152) Academic Press; Ausubel, et al. (eds. 1999 and supplements) Cunent Protocols Lippincott; and Sambrook, et al. (2001) Molecular Cloning: A Laboratory Manual (3d ed., Vol. 1-3) CSH Press. In a prefened embodiment, cancer proteins and modulators are administered as therapeutic agents, and can be formulated as outlined above. Similarly, cancer genes (including both the full-length sequence, partial sequences, or regulatory sequences of the cancer coding regions) can be administered in a gene therapy application. These cancer genes can include inhibitory applications, e.g., as inhibitory RNA, gene therapy (e.g., for incoφoration into the genome), or antisense compositions.
Cancer polypeptides and polynucleotides can also be administered as vaccine compositions to stimulate HTL, CTL, and antibody responses. Such vaccine compositions can include, e.g., lipidated peptides (see, e.g.,Vitiello, et al. (1995) J. Clin. Invest. 95:341-349), peptide compositions encapsulated in poly(DL-lactide-co-glycolide) ("PLG") microspheres (see, e.g., Eldridge, et al. (1991) Molec. Immunol. 28:287-294,; Alonso, et al. (1994) Vaccine 12:299-306; Jones, et al. (1995) Vaccine 13:675-681), peptide compositions contained in immune stimulating complexes (ISCOMS) (see, e.g., Takahashi, et al. (1990) Nature 344:873- 875; Hu, et al. (1998) Clin Exp Immunol. 113:235-243), multiple antigen peptide systems (MAPs) (see, e.g., Tarn (1988) Proc. Natl. Acad. Sci. USA 85:5409-5413; Tarn (1996) Immunol. Methods 196:17-32), peptides formulated as multivalent peptides; peptides for use in ballistic delivery systems, typically crystallized peptides, viral delivery vectors (Perkus, et al., p. 379, in Kaufrnarm (ed. 1996) Concepts in Vaccine Development de Gruyter; Chakrabarti, et al. (1986) Nature 320:535-537; Hu, et al. (1986) Nature 320:537-540; Kieny, et al. (1986) Bio/Technology 4:790-795; Top, et al. (1971) J. Infect. Pis. 124:148-154; Chanda, et al. (1990) Virology 175:535-547), particles of viral or synthetic origin (see, e.g., Kofler, et al. (1996) J. Immunol. Methods 192:25-35; Eldridge, et al. (1993) Sem. Hematol. 30:16-24; Falo, et al. (1995) Nature Med. 1 :649-653), adjuvants (Wanen, et al. (1986) Annu. Rev. Immunol. 4:369- 388; Gupta, et al. (1993) Vaccine 11:293-306), liposomes (Reddy, et al. (1992) J. Immunol. 148:1585-1589; Rock (1996) Immunol. Today 17:131-137), or, naked or particle absorbed cDNA (Ulmer, et al. (1993) Science 259:1745-1749; Robinson, et al. (1993) Vaccine 11:957- 960; Shiver, et al., p 423, in Kaufmann (ed. 1996) Concepts in Vaccine Development de Gruyter; Cease and Berzofsky (1994) Annu. Rev. Immunol. 12:923-989; and Eldridge, et al.
(1993) Sem. Hematol. 30:16-24). Toxin-targeted delivery technologies, also known as receptor mediated targeting, such as those of Avant Immunotherapeutics, Inc. (Needham, Massachusetts) may also be used.
Vaccine compositions often include adjuvants. Many adjuvants contain a substance designed to protect the antigen from rapid catabolism, such as aluminum hydroxide or mineral oil, and a stimulator of immune responses, such as lipid A, Bortadella pertussis, or Mycobacterium tuberculosis derived proteins. Certain adjuvants are commercially available as, e.g., Freund's incomplete Adjuvant and Complete Adjuvant (Difco Laboratories, Detroit, MI); Merck Adjuvant 65 (Merck and Company, Inc., Rahway, NJ); AS-2 (SmithKline Beecham, Philadelphia, PA); aluminum salts such as aluminum hydroxide gel (alum) or aluminum phosphate; salts of calcium, iron, or zinc; an insoluble suspension of acylated tyrosine; acylated sugars; cationically or anionically derivatized polysaccharides; polyphosphazenes; biodegradable microspheres; monophosphoryl lipid A and quil A. Cytokines, such as GM-CSF, interleukin-2, -7, -12, and other like growth factors, may also be used as adjuvants.
Vaccines can be administered as nucleic acid compositions wherein DNA or RNA encoding one or more of the polypeptides, or a fragment thereof, is administered to a patient. This approach is described, for instance, in Wolff et. al. (1990) Science 247:1465-1468, as well as U.S. Patent Nos. 5,580,859; 5,589,466; 5,804,566; 5,739,118; 5,736,524; 5,679,647; WO 98/04720; and in more detail below. Examples of DNA-based delivery technologies include "naked DNA", facilitated (bupivicaine, polymers, peptide-mediated) delivery, cationic lipid complexes, and particle-mediated ("gene gun") or pressure-mediated delivery (see, e.g., U.S. Patent No. 5,922,687).
For therapeutic or prophylactic immunization puφoses, the peptides of the invention can be expressed by viral or bacterial vectors. Examples of expression vectors include attenuated viral hosts, such as vaccinia or fowlpox. This approach involves the use of vaccinia virus, e.g., as a vector to express nucleotide sequences that encode cancer polypeptides or polypeptide fragments. Upon introduction into a host, the recombinant vaccinia virus expresses the immunogenic peptide, and thereby elicits an immune response. Vaccinia vectors and methods useful in immunization protocols are described in, e.g., U.S. Patent No. 4,722,848. Another vector is BCG (Bacille Calmette Guerin). BCG vectors are described in Stover, et al. (1991) Nature 351 :456-460. A wide variety of other vectors are availablel for therapeutic administration or immunization, e.g., adeno and adeno-associated virus vectors, retroviral vectors, Salmonella typhi vectors, detoxified anthrax toxin vectors, and the like. See, e.g., Shata, et al. (2000) Mol Med Today 6:66-71; Shedlock, et al. (2000) J. Leukoc. Biol. 68:793- 806; Hipp, et al. (2000) In Vivo 14:571-85.
Methods for the use of genes as DNA vaccines are well known, and include placing a cancer gene or portion of a cancer gene under the control of a regulatable promoter or a tissue- specific promoter for expression in a cancer patient. The cancer gene used for DNA vaccines can encode full-length cancer proteins, but more preferably encodes portions of the cancer proteins including peptides derived from the cancer protein. In one embodiment, a patient is immunized with a DNA vaccine comprising a plurality of nucleotide sequences derived from a cancer gene. For example, cancer-associated genes or sequence encoding sub fragments of a cancer protein are introduced into expression vectors and tested for their immunogenicity in the context of Class I MHC and an ability to generate cytotoxic T cell responses. This procedure provides for production of cytotoxic T cell responses against cells which present antigen, including intracellular epitopes.
In a prefened embodiment, DNA vaccines include a gene encoding an adjuvant molecule with the DNA vaccine. Such adjuvant molecules include cytokines that increase the immunogenic response to the cancer polypeptide encoded by the DNA vaccine. Additional or alternative adjuvants are available.
In another prefened embodiment, cancer genes find use in generating animal models of cancer. When the cancer gene identified is repressed or diminished in cancer tissue, gene therapy technology, e.g., wherein inhibitory or antisense RNA directed to the cancer gene will also diminish or repress expression of the gene. Animal models of cancer find use in screening for modulators of a cancer-associated sequence or modulators of cancer. Similarly, transgenic animal technology, including gene knockout technology, e.g., as a result of homologous recombination with an appropriate gene targeting vector, will result in the absence or increased expression of the cancer protein. When desired, tissue-specific expression or knockout of the cancer protein may be necessary.
It is also possible that the cancer protein is overexpressed in cancer. As such, transgenic animals can be generated that overexpress the cancer protein. Depending on the desired expression level, promoters of various strengths can be employed to express the transgene. Also, the number of copies of the integrated transgene can be determined and compared for a determination of the expression level of the transgene. Animals generated by such methods will find use as animal models of cancer and are additionally useful in screening for modulators to treat cancer. Kits for Use in Diagnostic and/or Prognostic Applications
For use in diagnostic, research, and therapeutic applications suggested above, kits are also provided by the invention. In diagnostic and research applications, such kits may include at least one of the following: assay reagents, buffers, cancer-specific nucleic acids or antibodies, hybridization probes and/or primers, antisense polynucleotides, ribozymes, dominant negative cancer polypeptides or polynucleotides, small molecule inhibitors of cancer-associated sequences etc. A therapeutic product may include sterile saline or another pharmaceutically acceptable emulsion and suspension base. hi addition, the kits may include instructional materials containing instructions (e.g., protocols) for the practice of the methods of this invention. While the instructional materials typically comprise written or printed materials, they are not limited to such. A medium capable of storing such instructions and communicating them to an end user is contemplated by this invention. Such media include, but are not limited to, electronic storage media (e.g., magnetic discs, tapes, cartridges, chips), optical media (e.g., CD ROM), and the like. Such media may include addresses to internet sites that provide such instructional materials.
The present invention also provides for kits for screening for modulators of cancer- associated sequences. Such kits can be prepared from readily available materials and reagents. For example, such kits can comprise one or more of the following materials: a cancer-associated polypeptide or polynucleotide, reaction tubes, and instructions for testing cancer-associated activity. Optionally, the kit contains biologically active cancer protein. A wide variety of kits and components can be prepared according to the present invention, depending upon the intended user of the kit and the particular needs of the user. Diagnosis would typically involve evaluation of a plurality of genes or products. The genes will typically be selected based on conelations with important parameters in disease which may be identified in historical or outcome data.
EXAMPLES Example 1 : Gene Chip Analysis
Molecular profiles of various normal and cancerous tissues were determined and analyzed using gene chips. RNA was isolated and gene chip analysis was performed as described (Glynne, et al. (2000) Nature 403:672-676; Zhao, et al. (2000) Genes Dev. 14:981- 993).
Table 1 lists medical conditions, abnormalities, or organs affected by disease, referred to in Tables 2A 68, for which markers have been identified, and other related medical conditions (including vaπous stages and/or metastases) in which those markers will also be useful, e g , in therapeutic, diagnostic, prognostic, subsettiπg vaccine, and other uses blood vessels/angiogenesis hemangiomas, lymphangiomas, wound healing, tissue remodeling, psoπasis, ischemic, heart disease, inflammatory diseases (e g , arthπtis, asthma, chronic bronchitis), atherosclerosis, endometriosis, presumed ocular histoplasmosis syndrome, hypoxia, solid tumors, lymphomas, autoimmune diseases (e g , RA, SLE, juvenile chronic arthπtis, pigmented villonodular synovitis, etc ), retinal neovasculaπzation syndromes (e g , diabetic retinopathy, macular degeneration, presumed ocular histoplasmosis syndrome, etc ), scleπtis/conjunctivitis, hypertrophic scars (keloid), birth control, utenne fibroids bladder carcinoma in situ, papillary carcinomas, transitional cell carcinoma bone marrow Ewing sarcoma sarcomas aπsiπg from skeletal and extraskeletal connective tissues, including the peπpheral nervous system brain glioblastoma, oligodendroglioma, anablastic astrocytoma, meningioma, medulablastoma, neuroblastoma, ependymo a, schwannoma cramopharyπgioma, pmeoblastoma, pineocytoma breast ductal carcinoma in situ, lobular carcinoma in situ cervix cancer of the cervix, vagina, or vulva colon/rectum precaπcerous colorectal disease (e , neoplastic polyps (adenomas), familial adenomatous polyposis, ulcerative colitis), colon cancer, e g , epithelial tumor (e g , adenocarcinoma, mucmous adenocarcinoma, signet-πng cell adenocarcinoma squamous cell carcinoma, adenosquamous carcinoma, undifferentiated carcinoma, unclassified carcinoma), caπnoid tumor (e g , argentaffiπ, πonargentaffin, composite), non-epithelial tumor (e g , leimyo sarcoma, others), inflammatory bowel disease (e g , ulcerative colitis, Crohn's disease (granulomatous colitis), dysplasia), rectal cancer, cancer of the anal region (e g , squamous cell carcinoma, transitional carcinoma, adenocarcinoma, carcinoma, papillary villous carcinoma, mucmous adenocarcinoma, melanoma) esophagus premalignant or predisposing conditions (e g , esophagitis), squamous cell cancers (e g , cancers of the head and neck, lung, or cervix), gastrodigestive carcinomas (eg , cancers of the stomach, colon, or rectum) fibrosis lung fibrosis (idiopathic pulmonary fibrosis, hypersensitivity pneumonitis.inlerstitial pneumonitis, nonspecific idiopathic pneumonitis), chronic obstructive pulmonary disease
(e g , emphysema, chronic bronchitis), asthma, bronchiectasis, cirrhosis (liver fibrosis), renal fibrosis, scleroderma, wound healing head and neck tumors of the nasal cavity, paranasal sinuses, nasopharynx, oral cavity, oral pharynx, lip, larynx, hypopharynx, salivary glands, paragangliomas, esophagus kidney clear cell (πonpapillary) carcinoma, papillary carcinoma, chromophobe renal carcinoma, hypemephroma, adenocarcinoma, sporadic renal carcinomas, hereditary renal carcinomas (von Hippel-Lindau disease), carcinoma of the renal pelvis, ureteral carcinoma, fibroma, papillary adenoma, angiomyolipoma, oncocytoma leukocytes acute lymphoblastic leukemia/lymphoma, mafignant transformation of immature, precursor 8 (pre 8) or precursor T (pre-T) lymphocytes, or lymphoblasts, arthπtis, inflammation, wound healing liver hepatitis (e g , types A, B, C), benign epithelial tumors and tumor bile conditions, pπmary malignant epithelial tumors, pπmary malignant meseπchymal tumors, tumors of the gallbladder or bile duct lung lung cancer, small cell lung carcinoma (oat cell carcinoma), non small cell carcinomas (e g , squamous cell carcinoma adenocarcinoma large cell lung carcinoma, carcmoid, granulomatous), fibrosis (idiopathic pulmonary fibrosis, hypersensitivity pneumomtts.interstitial pneumonitis, nonspecific idiopathic pneumonitis), chronic obstructive pulmonary disease (e g , emphysema, chronic bronchitis), asthma bronchiectasis, esophageal cancer ovary ovaπan carcinoma (e g , epithelial (serous tumors, mucmous tumors, endometπoid tumors), germ cell (e g , teratomas, choπocarcmomas, polyembryomas, embryomal carcinoma, endodermal sinus tumor, dysgermmoma, gonadoblastoma), stromal carcinomas (e g , granulosal stromal cell tumors)), fallopian tube carcinoma, pentoneal carcinoma, leiomyo a pancreas adenocarcinoma, ductal adenocarcinoma, mucmous cyst adenocarcinoma, acinar cell carcinoma, unclassified large cell carcinoma, small cell carcinoma, pancreatoblastoma, duct-ectatic mucin hypersecreting tumor, mucmous cyst adenoma, papillary cystic neoplasm, serous cyst adenoma, diabetes melitis, chronic pancreatitis prostate epithelial neoplasms (e g , adenocarcinoma, small cell tumors, transitional cell carcinoma, carcinoma in situ, and basal cell carcinoma), carcinosarcoma, non-epithelial neoplasms (e g , mesenchymal and lymphoma), germ cell tumors, prostatic mtraepithelial neoplasia (PIN), hormone independent prostate cancer, benign prostate hyperplasia, prostatitis skin/melanoma melanoma lentigo (common benign localized hyperplasia of melanocytes), nevocellular nevi (congenital or acquired neoplasm of melanocytes), actinic keratosis (overgrowth of outer layers of skin), basal cell carcinoma, Merkel cell carcinoma, benign fibrous histiocytoma (dermal neoplasms of fibroblasts and histiocytes), dermatofibrosarcoma protuberans (well differentiated fibrosarcoma of the skin), xanthomas (tumor-like collections of foamy histiocytes within the dermis), dermal vascular tumors, seborrheic keratoses (benign tumor), acanthosis nigπcans (benign or malignant hyperplasia and hyperpigmentatioπ of skin), and squamous cell carcinomas of the skin, lung, cervix, esophagus, uterus, head, neck, or bladder stomach adenocarcinoma, squamous cell carcinoma adenoacanthoma carcmoid leiomyosarcoma, gastπtis (chronic atrophic, H pylon associated), hyperplastic polyps, lipoma leiomyoma, esophageal adenocarcinomas testicles germ cell tumors (including seminomas, embryonal carcinomas, teratomas, choπocarcmomas, yolk sac tumors), sex chord stromal tumors (including Leydig cell tumors, Sertoli cell tumors, and Granulosa cell tumors), germ cell and gonadal stromal elements (e g , gonadoblastomas), adnexal and paratesticular tumors (e g , mesotheliomas, soft tissue sarcomas, and adnexal of the rete testes), miscellaneous neoplasms (including carcmoid, lymphoma, and cysts) uterus epithelial tumors (e g , endometπoid, papillary endometπoid, papillary serous, clear cell, mucmous), mesenchymal tumors (e , endometnal stromal sarcoma, leiomyosarcoma nonspecific sarcomas), mixed tumors (e g , malignant mixed mulleπan tumors, adenosarcoma) Tables 2B 66C list accession numbers for Pkeys lacking UnigenelD s for Tables 2A-66C, respectively For each probeset is listed gene cluster number from which oligonucleotides were designed Gene clusters were compiled using sequences denved from Genbank ESTs and mRNAs These sequences were clustered based on sequence similaπty using Clustering and Alignment Tools (DoubleTwist, Oakland California) Genbank accession numbers for sequences comprising each cluster are listed in the "Accession" column
Tables 2C-66C list genomic positioning for Pkeys lacking Unigene ID's and accession numbers in Tables 2A-66C, respectively For each predicted exon is listed genomic sequence source used for prediction Nucleotide locations of each predicted exon are also listed
TABLE 2A ABOUT 1031 GENES UP-REGULATED IN ACUTE LY PHOCYTIC LEUKEMIA (ALL)
Table 2A lists about 1031 genes up regulated in acute lymphocyte leukemia (ALL) compared to normal adult tissues These were selected from 35403 probesets on the
Affymetπx/Eos Hu01 GeneChip array such that the ratio of "average" leukemia to "average" normal adult tissues was greater than or equal to 1 7 The "average" leukemia level was set to the 75* percentile amongst various ALL samples The "average" normal adult tissue level was set to the 85* percentile amongst various non malignant tissues In order to remove gene specific background levels of non-specific hybndization, the 75th percentile value amongst vaπous non malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated
Pkey Unique Eos probeset identifier number
ExAccn Exemplar Accession number, Genbank accession number UnigenelD Unigene number
Unigene Title Unigene gene title
R1 Ratio of leukemia to normal body tissue
Pkey ExAcc UniGenelD UmGene Title R1 100458 S74019 Hs 247979 pre-B lymphocyte gene 1 46 8
113089 T40707 Hs 270862 ESTs 204
106956 R06428 Hs 226351 ESTs 158
101447 M21305 gb Human alpha satellite and satellite 3 138
113009 T23699 Hs7246 ESTs 125 126947 Z40778 Hs 191837 ESTs 11 4
100893 BE245294 Hs 180789 S164 protein 11 1
101050 AU077324 Hs 1832 neuropeptideY 11 0
132114 NM 006152 Hs 40202 lymphoid-restπcted membrane protein 107 101304 AA001021 Hs6685 thyroid hormone receptor mteractor 8 104
105667 AA767526 Hs22030 paired box gene 5 (B-cell lineage specif 91
112727 T91029 Hs 15069 ESTs 90
109788 T79971 Hs 12432 Homo sapiens clone 24407 mRNA sequence 87
113374 T79925 Hs269165 ESTs, Weakly similar to ALU1_HUMAN ALU S 78
130466 W19744 Hs 180059 Homo sapiens cDNA FLJ20653 fis, clone KA 77
109384 AA219172 Hs 86849 ESTs 76
112602 AW004045 Hs 203365 ESTs 66
125278 AI218439 Hs 129998 enhancer of polycomb 1 65
112167 N99591 Hs 25587 ESTs, Weakly similar to T00329 hypotheti 64
116355 AA789133 Hs 88650 ESTs 58
123440 AI733692 Hs 112488 ESTs 55
100918 AK001335 Hs31137 protein tyrosine phosphatase, receptor t 54
101879 AA176374 Hs 243886 nuclear autoantigeπic sperm protein (his 54
109260 AW978515 Hs 131915 KIAA0863 protein 54
129213 AI146494 Hs 109525 ESTs, Weakly similar to IRX2_HUMAN IROQU 54
120809 AA346495 gb EST52657 Fetal heart II Homo sapiens 54
105498 H68279 Hs 24937 transformer-2 alpha (htra-2 alpha) 51
114840 AA447591 Hs 87359 ESTs, Highly similar to RB18_HUMAN RAS-R 50
103304 BE561801 Hs2484 T-cell leukemia/lymphoma 1A 49
113983 W87415 Hs 55296 HLA-B associated transcπpt-1 48
115844 AI373062 Hs 332938 hypothetical protein MGC5370 48
120712 AF193339 Hs 102506 eukaryotic translation initiation factor
107794 AA019255 gb ze56e10 si Soares retina N2b4HR Homo 47
135101 U82275 Hs 94498 leukocyte immuπoglobul -like receptor, 46
129898 AI672731 Hs 13256 ESTs 46
113494 T91451 Hs 86538 ESTs 46
115004 AA329340 Hs4867 maπnosyl (alpha-1,3-) glycoprotein beta- 45
113074 AK001335 Hs31137 protein tyrosine phosphatase, receptor t 45
112326 R55822 Hs4268 ESTs 44
105169 BE245294 Hs 180789 S164 protein 44
117048 H89732 Hs230113 EST 43
123133 AA487264 Hs 154974 Homo sapiens mRNA cDNA DKFZp667N064 (fr 43
111394 AA412227 Hs 16131 hypothetical protein FU12876 43
106112 AL117518 Hs 3686 KIAA0978 protein 42
114414 AW152166 Hs 182113 ESTs 42
125219 AI804331 Hs 99423 ATP-dependent RNA helicase 42
114995 AA769266 Hs 193657 ESTs 42
123338 AA504249 Hs 187585 ESTs 41
126666 AA648886 Hs 151999 ESTs 41
112908 BE281000 Hs 3530 TLS-associated senne-argmine protein 2 41
116640 X89984 Hs 211563 B-cell CLL/lymphoma7A 40
109292 AW975746 Hs 188662 KIAA1702 protein 40
131724 AK001335 Hs31137 protein tyrosine phosphatase, receptor t 40
119772 AJ250839 Hs58241 gene for seπne/threonine protein kinase 40
134453 AI272141 Hs 83484 SRY (sex determining region Y) box 4 40
123562 AA177088 Hs 190065 ESTs 40
103226 X75042 Hs 4313 v-rel avian reticuloendotheliosis viral 39
127610 AA960867 Hs 150271 ESTs, Highly similar to unnamed protein 39
119873 AI660149 Hs 44865 lymphoid enhancer-binding factor 1 39
115553 AJ275986 Hs 71414 transcription factor (S IF gene) 39
131844 AI419294 Hs 324342 ESTs 38
123360 AA532718 Hs 178604 ESTs 38
111180 A1798851 Hs 283108 hemoglobin, gamma G 38
129426 AF077953 Hs 111323 Protein inhibitor of activated STAT X 38
105434 AA252111 Hs 15200 ESTs 38
119073 BE245360 Hs 279477 ESTs 38
127003 AW816515 Hs 173540 ATPase, Class V, type 10D 37
119325 T51136 Hs90489 ESTs 37
115998 AA448488 Hs 336629 πbosomal protein L44 37
119830 AW054922 Hs 53478 Homo sapiens cD A FLJ 12366 fis, clone MA 37
104584 AA704538 Hs 193777 ESTs 36
105212 AA205334 Hs 324278 Homo sapiens mRNA, cDNA DKFZp566M063 (f 36
109223 AW000714 Hs65818 ESTs 36
112605 R79374 Hs 29852 ESTs 35
105733 AA767669 Hs 10242 ESTs 35
120562 BE244580 Hs302267 hypothetical protein FLJ 10330 35
112268 W39609 Hs 22003 solute earner family 6 (neurotraπsmitte 35
127834 AW301022 Hs 337631 EST 35
115147 AA745781 Hs 38399 hypothetical protein MGC2454 35
115185 BE299677 Hs 105461 hypothetical protein FLJ20357 35
113921 AW976530 Hs 28355 hypothetical protein FLJ22402 35
115835 AA521410 Hs41371 ESTs 35
123503 AW975051 Hs 293156 ESTs, Weakly similar to I78885 seπne/th 35
128527 AA504583 Hs101047 transcπption factor 3 (E2A immunoglobul 34
128743 R44284 Hs2730 heterogeneous nuclear πbonucleoprotein 34
117031 H88353 gb yw21a02 s1 Morton Fetal Cochlea Homo 34
123149 AI734179 Hs 105676 ESTs 34
102581 AU077228 Hs77256 enhancer of zeste (Drosophila) homolog 2 34
103158 BE242587 Hs 118651 hematopoietically expressed homeobox 34
107599 AW664072 Hs 60136 ESTs 34
125556 AB033064 Hs334806 KIAA1238 protein 34
103331 AI825463 Hs 147996 protein kinase, X-lmked 34 114387 AI655141 Hs 107720 ESTs, Weakly similar to A54295 iπterfer 34
119040 R02394 Hs 269436 ESTs, Moderately similar to PC4259 fern 34
100305 NM 004941 Hs 171872 DEAD/H (Asp-Glu Ala-Asp/His) box polypep 34
129818 T71092 Hs 172572 hypothetical protein FLJ20093 33
133445 AC005262 Hs 73797 guanine nucleotide binding protein (G pr 33
132111 AW500857 Hs 40137 aπaphase promoting complex 1, meioticch 33
105292 AF128542 Hs 166846 polymerase (DNA directed), epsilon 33
118397 BE139479 Hs 161492 ESTs 33
118922 AW206193 Hs 91065 hypothetical protein DKFZp761B2423 32
132344 AW977189 Hs 45719 KIAA0823 protein 32
129889 AA810932 Hs 131899 ESTs, Weakly similar to T00370 hypotheti 32
123670 AI189844 Hs 112708 ESTs, Moderately similar to ZN91_HUMAN Z 32
116291 A 410377 Hs 41502 hypothetical protein FU21276 32
105289 AB020638 Hs 103000 KIAA0831 protein 32
105583 AA278907 Hs 3530 TLS-associated seπne-argmme protein 32
104796 BE620712 Hs 33026 hypothetical protein PP2447 32
111657 R07364 Hs 268667 ESTs, Weakly similar to ALU1_HUMAN ALU 32
134174 AF283770 Hs 79630 CD79A antigen (immunoglobulm-associated 32
126077 M78772 Hs 210836 ESTs 3 1
133733 AK000476 Hs 75798 hypothetical protein 31
124847 W07701 Hs 304177 Homo sapiens clone FLB8503 PR02286 mRNA, 3 1
127879 AA768098 Hs 189079 ESTs 3 1
113108 AW516695 Hs 8438 ESTs 31
110343 AW136703 Hs 17268 ESTs 3 1
102935 BE561850 Hs 80506 small nuclear nboπucleoprote polypept 31
111676 AB040882 Hs 109778 KIAA1449 protein 3 1
127311 AA492582 Hs 322404 hypothetical protein MGC4175 3 1
108830 AA131743 Hs 193352 ESTs 31
111330 BE247767 Hs 18166 KIAAO870 protein 3 1
104246 AF016032 Hs 201377 lysosomal apyrase- ke 1 3 1
126668 AA011616 Hs 269877 ESTs 3 1
124724 H20816 Hs 112423 Homo sapiens mRNA, cDNA DKFZp586l1420 (f 3 1
114794 AI751157 Hs 101395 hypothetical protein MGC11352 3 1
134599 X99226 Hs 284153 Fancora anemia, complementation group A 30
130314 NM 014674 Hs 154332 KIAA0212 gene product 30
100265 D38521 Hs 112396 KIAA0077 protein 30
115005 AI760825 Hs 111339 ESTs 30
123433 AW450922 Hs 112478 ESTs 30
127798 AA737068 Hs 294078 ESTs 30
117403 H84455 Hs 40639 ESTs 30
107111 AI298448 Hs 22670 chrornodomain helicase DNA binding protei 30
105698 AW957300 Hs 294142 ESTs, Weakly similar to C55663 oligodend 30
108358 M81933 Hs 1634 cell division cycle 25A 30
132066 AI929392 Hs 181195 DnaJ (Hsp40) homolog, subfamily B membe 29
130303 BE245294 Hs 180789 S164 protein 29
104596 AF067804 Hs 15423 hypothetical protein HDCMC04P 29
112197 NM 003655 Hs 5637 ESTs 29
132809 AF036144 Hs 5734 meningioma expressed antigen 5 (hyaluron 29
100877 X80821 Hs 27973 KIAA0874 protein 29
108147 AI972094 Hs 286221 Homo sapiens cDNA FLJ13741 fis, clone PL 29
133674 AW851121 Hs 75497 Homo sapiens cDNA FU22139 fis, clone H 29
129001 AA443323 Hs 107812 BPOZ protein 29
131920 BE002320 Hs 287864 Homo sapiens cDNA FLJ14030 fis clone HE 29
134709 NM 006290 Hs 211600 tumor necrosis factor, alpha induced pro 28
113577 AI300699 Hs 278937 PRO0470 protein 28
115839 BE300266 Hs 28935 traπsducin like enhancer of split 1 , horn 28
129969 N57818 gb yv59d07 si Soares fetal liver spleen 28
128659 AW630087 Hs 103315 tπnucleotide repeat containing 1 28
105011 BE091926 Hs 16244 mitotic spindle coiled-coil related prot 28
129294 AF172940 Hs 184542 CGI-127 protein 28
104518 H20816 Hs 112423 Homo sapiens mRNA, cDNA DKFZp586l1420 (f 27
107796 AA058848 Hs 60797 ESTs 27
106331 AB037742 Hs 24336 KIAA1321 protein 27
127692 AI021912 Hs 187983 ESTs 27
131916 AA025976 Hs 34569 ESTs 27
124971 T23800 Hs 151001 hypothetical protein FLJ14728 27
129428 AA256906 Hs 111364 ESTs, Weakly similar to ubiquitous TPR m 27
118348 AW408586 Hs 91052 ESTs, Moderately similar to ALU5JHUMAN A 27
113219 T59257 Hs 269528 ESTs, Moderately similar to ALU8_HUMAN A 27
131720 Z68128 Hs 3109 Rho GTPase activating protein 4 27
109593 AW196801 Hs 6685 thyroid hormone receptor mteractor 8 27
135359 AF043722 Hs 99491 PAS guanyl releasing protein 2 (calcium 27
131689 AB012124 Hs 30696 transcπption factor-like 5 (basic helix 27
117457 N29682 Hs 44071 ESTs, Weakly similar to ALU5_HUMAN ALU 27
121073 H46199 Hs 112184 DKFZP586J0619 protein 27
125069 H81306 Hs 194485 ESTs 27
116456 AI381911 Hs 334859 KIAA1814 protein 27
124271 AW293223 Hs 8928 hypothetical protein FU20291 27
112369 AW966243 Hs 4243 hypothetical protein FLJ12650 27
115866 AW062629 Hs 52081 KIAA0867 protein 27
132543 BE568452 Hs 5101 protein regulator of cytokinesis 1 27
124494 N54831 Hs 271381 ESTs, Weakly similar to I38022 hypothet 27
104799 AA029703 gb ze95h08 s1 Soares_fetal_heart_NbHH19W 27 120510 AI796395 Hs 111377 ESTs 26
129781 AA306090 Hs 124707 ESTs 26
122698 AA456112 Hs 99410 ESTs 26
106995 AB023139 Hs 37892 K1AA0922 protein 26
105502 BE464016 Hs 238956 ESTs 26
128671 AI885045 Hs 211586 phosphoιπosιtιde-3-kιnase, regulatory s 26
107059 BE614410 Hs 23044 RAD51 (S cerevisiae) homolog (E coli Re 26
126502 T10077 Hs 13453 hypothetical protein FLJ 14753 26
129703 BE388665 Hs 179999 Homo sapiens, clone IMAGE 3457003, mRNA 26
111219 N68836 Hs 19247 ESTs, Moderately similar to ALUCHUMAN 26
133529 W45623 Hs 74571 ADP-πbosylation factor 1 26
125626 AI038854 Hs 180789 S164 protein 26
111189 N67603 Hs 272130 ESTs, Weakly similar to S65824 reverse 26
113146 BE151985 Hs 5722 hypothetical protein FU23316 26
125562 AI494372 Hs 98968 hypothetical protein FLJ23058 26
102263 U29171 Hs 75852 casein kinase 1, delta 26
118835 AA535246 Hs 50852 ESTs 26
103141 X66113 Hs 75584 polymyositisfecleroderma autoantigeπ 2 ( 26
109598 R40515 Hs 21248 ESTs 26
127262 AA828125 gb od71 a09 si NCI_CGAP_Ov2 Homo sapiens 26
129620 D79338 Hs 239720 CCR4-NOT traπscπption complex, subunit 26
125905 AI678638 Hs 6456 chaperomn containing TCP1, subunit 2 (b 26
123255 AA830335 Hs 105273 ESTs 26
133160 N54968 Hs 66309 hypothetical protein MGC11061 26
109638 AW977747 Hs 119120 E3 ubiquitin ligase SMURF1 26
119896 AA731836 Hs 137319 ESTs 26
134770 M89957 Hs 89575 CD79B antigen (immunoglobulm-associated 26
119403 AL117554 Hs 119908 nucleolar protein NOP5/NOP58 26
129563 AF119664 Hs 27299 transcπptional regulator protein 26
111719 AI655806 Hs 179262 ESTs 26
103982 AA218558 Hs 7905 sorting nexin 9 26
125032 T74884 gb yc58d02 s1 Stratagene liver (937224) 25
131426 AL122045 Hs 26703 CCR4-NOT transcription complex, subunit 25
131938 AF176085 Hs 34956 neural polypynmidme tract binding prot 25
102450 U48251 Hs 75871 protein kinase C binding protein 1 25
133761 AF041430 Hs 75922 brain protein 13 25
126339 AA152106 Hs 4859 cyclm L anιa-6a 25
118967 AI668670 Hs 216756 ESTs 25
123110 AA486256 Hs 193510 EST 25
114092 H81213 Hs 14825 ESTs Weakly similar to KIAA1503 protein 25
113247 T63856 Hs 193430 ESTs, Weakly similar to 2109260A B cell 25
122024 AA431296 Hs 139433 ESTs 25
106657 AW854339 Hs 33476 hypothetical protein FLJ11937 25
126127 N95428 gb zb80d09 s1 Soares senescent fibroblas 25
111836 R58394 Hs 25119 ESTs, Weakly similar to YEX0 YEAST HYPOT 25
121470 AA558958 Hs 324751 ESTs 25
120132 W57554 Hs 125019 ESTs 25
107731 AA016086 Hs 272106 ESTs, Weakly similar to I38022 hypotheti 25
118122 AI186671 Hs 48008 ESTs 25
106589 AK000933 Hs 28661 Homo sapiens cDNA FU10071 fis, clone HE 25
129948 AI537162 Hs 263988 ESTs 25
115652 BE093589 Hs 38178 hypothetical protein FLJ23468 25
103076 NM 00103^ 1 Hs 5319 πbonucleotide reductase M2 polypeptide 25
131019 W28614 Hs 306155 choπoπic somatomammotropin hormone 1 (p 25
100512 D13317 Hs 78915 GA-binding protein transcπption factor, 25
105393 AF167570 Hs 256583 interieukin enhancer binding factor 3, 9 25
100571 L14561 Hs 78546 ATPase, Ca++ transporting, plasma membra 25
106890 AA489245 Hs 88500 mitogeπ-activated protein kinase 8 mte 25
104276 AW965275 Hs 284288 hqp0256 protein 25
113283 T66813 Hs 12947 EST 25
118078 N54321 Hs 47790 EST 25
120796 AI247356 Hs 96820 ESTs 25
106265 AA412176 Hs 236463 Homo sapiens mRNA cDNA DKFZp586l0521 (f 25
102507 U52154 Hs 193044 potassium inwardly rectifying channel, s 25
106508 AI205785 Hs 30348 ESTs 25
104568 AW629981 Hs 172182 poly(A)-bιndιng protein, cytoplasmic 1 25
103698 AA001021 Hs 6685 thyroid hormone receptor mteractor 8 25
113947 W84768 gb zh53d03 s1 SoaresJetal_lιver_spleen_ 25
132112 AL021938 Hs 40154 jumonji (mouse) homolog 25
129052 BE275031 Hs 158210 hypothetical protein MGC2555 24
117265 AA451966 Hs 43005 RAB9-lιke protein 24
107834 AA253162 Hs 40838 ESTs 24
113119 T47910 gb yb18b11 s1 Stratagene fetal spleen (9 24
133726 AI803188 Hs 252716 oxysterol binding protein related protei 24
120548 AA280356 Hs 187634 ESTs 24
121545 AA412442 Hs 98132 ESTs 24
131136 AB033099 Hs 23413 KIAA1273 protein 24
126589 AWO27809 I Hs 187698 Homo sapiens cytomegalovirus partial fus 24
115475 AB033085 Hs 40193 hypothetical protein KIAA1259 24
103760 AA642973 Hs 183842 Ubiquitin B 24
127889 AI147408 Hs 144941 ESTs 24
124457 AK000680 Hs 266175 phosphoprotein associated with GEMs 24
113721 AF143885 Hs 18190 EST 24 129079 AK000157 Hs 108502 hypothetical protein FU20150 24
123530 AA608705 Hs 187772 ESTs 24
123592 AA805331 Hs 112637 ESTs 24
113474 R50752 Hs23856 hypothetical protein MGC5297 24
116728 F13687 Hs 227976 EST 24
101759 M80244 Hs 184601 solute earner family 7 (cationic ammo 24
131686 NM 012296 Hs 30687 GRB2-assocιated binding protein 2 24
127841 AW136558 Hs 125246 ESTs 24
102737 R51790 Hs 239483 Human clone 23933 mRNA sequence 24
129673 D38552 Hs 1191 KIAA0073 protein 24
133095 BE046490 Hs 180677 zinc finger protein 162 24
124540 N63232 gb yz39a12 s1 Morton Fetal Cochlea Homo 24
113609 T93263 Hs 16875 ESTs, Weakly similar to S23650 retrovir 24
128826 Z40313 Hs 106330 Homo sapiens clone IMAGE 23371 , mRNA seq 24
129059 AW069534 Hs 279583 CGI-81 protein 24
134092 AA218558 Hs7905 sorting nexin 9 24
132317 BE262438 Hs 44592 beta-1 ,4 mannosyltransferase 24
135278 AA399542 Hs 229671 EST, Moderately similar to PEPTIDYL-PROL 24
128468 T23625 Hs150580 putative translation initiation factor 2.4
127407 AW089514 Hs 279681 heterogeneous nuclear nboπucleoprotein 24
132342 AW162758 Hs45232 ESTs, Weakly similar to ALU5_HUMAN ALU S 24
113518 AW367788 Hs 323954 post eiotic segregation increased 2 lik 24
100330 AW410976 Hs77152 mmichromosome maintenance deficient (S 24
116046 BE395293 Hs 94491 hypothetical protein FU20297 24
123910 AA621262 Hs 179923 ESTs, Weakly similar to S65657 alpha-1 C- 24
101651 AL037111 Hs 75641 galactose-1-phosphate uπdylyltransferas 24
100114 X02308 Hs 82962 thymidylate synthetase 24
125038 AA812234 Hs 270134 hypothetical protein FLJ20280 24
135191 X16866 Hs 301086 cytochrome P450, subfamily HD (debπsoq 24
123258 AA490929 Hs 105274 ESTs, Weakly similar to RMS1_HUMAN REGUL 24
132380 AW373665 Hs 46853 ESTs 24
114046 BE018658 Hs 141003 Homo sapiens cDNA FLJ21691 fis, clone C 23
133582 BE391579 Hs 75087 Fas-activated seπne/threoπine kinase 23
134839 D63479 Hs 115907 diacylglycerol kinase, delta (130kD) 23
105734 A1952797 Hs 10888 hypothetical protein FU21709 23
101086 AA382524 Hs 250959 histatm 1 23
118349 N63786 Hs 94149 ESTs, Weakly similar to ALU1_HUMAN ALU S 23
101194 L20971 Hs188 phosphodiesterase 4B, cAMP-specific (dun 23
130588 AL030996 Hs 16411 hypothetical protein LOC57187 23
101875 BE241753 Hs 74592 special AT-πch sequence binding protein 23
118751 N74210 Hs 50454 ESTs 23
125174 W51835 Hs 231082 EST 23
105966 AA142984 Hs5344 adaptor-related protein complex 1, gamma 23
104624 AA353125 Hs 184721 ESTs 23
131263 AU077002 Hs 24950 regulator of G-protein signalling 5 23
105014 AA121123 Hs 269267 ESTs, Weakly similar to AF161361 1 HSPC 23
123423 AA598484 gb ae38f04 s1 Gessler Wilms tumor Homo s 23
128531 H03721 Hs 2953 πbosomal protein S15a 23
108876 AI733860 Hs 191453 ESTs 23
130215 BE301883 Hs 152707 glioblastoma amplified sequence 23
132232 AI522273 Hs 42640 ESTs 23
132664 AI740461 Hs 54542 ESTs 23
105991 AA215701 Hs 186541 ESTs Weakly similar to I38022 hypotheti 23
100253 D38024 Hs 157425 double homeobox, 2 23
105574 AA045281 Hs 266175 phosphoprotein associated with GEMs 23
100780 BE561958 Hs 302063 immunoglobulin heavy constant mu 23
134964 AI803516 Hs 272891 hippocalc like protein 4 23
132786 BE083422 Hs 56851 hypothetical protein MGC2668 23
104952 AW076098 Hs 74316 desmoplakm (DPI, DPII) 23
119127 AA708035 Hs 12248 ESTs 23
104857 AI920902 Hs 19058 ESTs, Moderately similar to S65657 alpha 23
107592 AA694264 Hs 60049 ESTs 23
113378 T80738 Hs 14757 ESTs 23
129228 U40714 Hs239307 tyrosyl tRNA synthetase 23
106898 AA490069 Hs 306676 Homo sapiens cDNA FLJ14302 fis, clone PL 23
130734 AW137091 Hs 18624 KIAA1052 protein 23
125728 AW954565 Hs 57987 B cell CLUIymphoma 11B (zinc finger pro 23
113697 T97183 Hs 17992 Homo sapiens mRNA, cDNA DKFZp434J1726 (f 23
107104 AU076640 Hs 15243 πucleolar protein 1 (120kD) 23
134267 AI174596 Hs 196209 RAE1 (RNA export 1, S pombe) homolog 23
105777 R42755 Hs 23096 ESTs 23
115306 AA280288 Hs 88746 ESTs 23
133363 AI866286 Hs 71962 ESTs, Weakly similar to B36298 proline-r Z3
129535 AA397972 Hs 169965 chimeπn (chimaeπn) 1 23
121520 AA412163 Hs 164785 ESTs 23
123808 AA620552 gb ae58g11 s1 Stratagene lung carcinoma 23
105700 AW58083C I Hs 35254 hypothetical protein FLB6421 23
120820 AA347417 Hs 96869 EST 23
128721 AW403911 Hs 266175 phosphoprotein associated with GEMs 23
107711 W96141 Hs 220687 ESTs 23
102564 U59423 Hs 79067 MAD (mothers against decapentaplegic, Dr 23
131868 AW40829.i Hs 33532 zinc finger protein 151 (pHZ-67) 23
122333 AA625872 Hs 98977 ESTs, Moderately similar to T34561 hypot 23 118865 AA736405 Hs 54530 ESTs 23
128952 AL043463 Hs 6755 RaP2 interacting protein 8 23
133772 BE379867 Hs 76038 isopentenyl diphosphate delta isomerase 23
111795 AI435437 Hs 24567 ESTs, Weakly similar to KBF3_HUMAN NUCL 23
103437 AV655598 Hs 184211 peptidase (mitochondπal processing) bet 23
123060 AA482027 Hs 142569 ESTs, Weakly similar to I38022 hypotheti 23
125466 R08234 Hs 180461 ESTs 23
100892 BE245294 Hs 180789 S164 protein 23
121613 AA416879 Hs 193195 ESTs, Weakly similar to 2109260A B cell 23
133665 AL036883 Hs 75450 delta sleep inducing peptide, immunoreac 22
129248 W04606 Hs 171637 hypothetical protein MGC2628 22
126153 H85692 Hs 40730 ESTs 22
125590 R23858 Hs 143375 Homo sapiens, clone IMAGE 3840937, mRNA, 22
104960 AA558677 Hs 8928 hypothetical protein FLJ20291 22
113941 AA531016 Hs 22399 hypothetical protein FU14824 22
112540 R69751 gb yι40a10 s1 Soares plxenta Nb2HP Homo 22
105322 T87179 Hs 16346 ESTs, Weakly similar to S57447 HPBRII-7 22
112003 AW978731 Hs 301824 hypothetical protein PR01331 22
134733 N87353 Hs 89421 CBF1 interacting corepressor 22
114620 AA642974 gb nr60h01 s1 NCI CGAP Lym3 Homo sapiens 22
123451 A1793211 Hs 165372 ESTs, Moderately similar to ALU1 HUMAN A 22
130850 AB040922 Hs 20237 DKFZP566C134 protein 22
105561 AA262881 Hs 323836 ESTs, Weakly similar to alternatively s 22
125957 H41694 gb yo06b06 r1 Soares adult brain N2b5HB5 22
130362 BE513050 Hs 279681 heterogeneous nuclear πbonucleoprotein 22
122682 AA984531 Hs 159293 ESTs 22
124250 AA350256 Hs 323875 EST, Weakly similar to 2109260A B cell 22
131392 AA235153 Hs 26320 TRABID protein 22
128845 AW503976 Hs 10649 basement membrane induced gene 22
130453 U80735 Hs 173854 PAX transcπption activation domain inte 22
126973 W46653 Hs 251928 nuclear pore complex interacting protein 22
103156 BE259039 Hs 129953 Ewing sarcoma breakpoint region 1 22
103163 AU077018 Hs 3235 keratin 4 22
109252 BE440157 Hs 85944 ESTs 22
131163 AA099524 Hs 23754 ESTs 22
115292 AA279956 Hs 88672 ESTs 22
122591 AI188219 Hs 99311 ESTs, Weakly similar to HSJ2_HUMAN DNAJ 22
124977 F04819 Hs 190452 KIAA0365 gene product 22
103319 X83492 Hs 82359 tumor necrosis factor receptor superfami 22
100370 D79989 Hs 184884 KIAA0167 gene product 22
128992 H04150 Hs 107708 ESTs 22
129928 AI338993 Hs 134535 ESTs 22
108451 AA079195 gb zm92h12 s1 Stratagene ovaπan cancer 22
133910 AW835281 Hs 77500 ubiquitin specific protease 4 (proto-onc 22
106288 AB037742 Hs 24336 KIAA1321 protein 22
134125 NM_014781 Hs 50421 KIAA0203 gene product 22
101379 X02994 Hs 1217 adenosine deaminase 22
112276 R53442 Hs 26038 ESTs, Weakly similar to I38022 hypothet 22
106251 R12607 Hs 35101 proline rich Gla (G carboxyglutamic acid 22
125394 BE178502 Hs 173772 ESTs, Weakly similar to I78885 seπne/th 22
103392 X94563 gb H sapiens dbi/acbp gene exon 1 & 2 22
112853 T02843 gb FB11 H5 Fetal brain Stratagene Homo s 22
133195 AI434760 Hs 279949 KIAA1007 protein 22
135060 AK001887 Hs 259842 protein kinase AMP-activated, gamma 2 n 22
131381 M92642 Hs 26208 collagen, type XVI, alpha 1 22
134104 L35253 Hs 79107 mitogen activated protein kinase 14 22
105225 AA211777 gb zn57d02 s1 Stratagene muscle 937209 H 22
131320 AA505691 Hs 145696 splicing factor (CC1 3) 22
114419 AI248013 Hs 106532 ESTs, Weakly similar to I38588 reverse t 22
103634 BE541733 Hs 180877 H3 histone family 3B (H33B) 22
134624 AF035119 Hs 8700 deleted in liver cancer 1 22
126524 Z45455 Hs 182447 heterogeneous nuclear πbonucleoprotein 22
115556 AL031778 Hs 797 nuclear transcπption factor Y, alpha 22
111898 R38944 Hs 183475 Homo sapiens clone 25061 mRNA sequence 22
100415 D86970 Hs 75822 TGFB1-mduced anti apoptotic factor 1 22
103898 AA248884 gb k3517 seq F Human fetal heart, Lambda 22
129501 AI631811 Hs 180403 STRIN protein 22
127251 AA936428 Hs 128638 ESTs 22
100613 X52078 Hs 101047 transcription factor 3 (E2A immunoglobul 22
116332 AA491208 Hs 62620 chromosome 6 open reading frame 1 22
128897 AW979134 Hs 10700 hypothetical protein 22
111777 AK001100 Hs 41690 desmocollin 3 22
128604 AI879099 Hs 102397 GIOT-3 for gonadotropin inducible traπsc 22
125585 AW298113 Hs 92909 SON DNA binding protein 22
129584 AV656017 Hs 184325 CGI-76 protein 22
114461 AA531187 Hs 126705 ESTs 22
121387 AA405854 gb zu66g08 s1 Soares_testιs_NHT Homo sap 22
109339 AA314554 Hs 27774 ESTs, Highly similar to AF1613491 HSPC0 22
129179 AW969025 Hs 109154 ESTs 22
106711 BE390125 Hs 143187 hypothetical protein 22
106424 H61005 Hs 37902 ESTs 22
123949 AA621665 Hs 208957 EST 22
127256 AI738610 Hs 267967 ESTs, Moderately similar to ALU8 HUMAN 22 104868 AF173867 Hs 28906 glucocorticoid modulatory element bindm 2 2
132984 BE539199 HS 62112 zinc finger protein 207 22
126383 AB032977 Hs 6298 KIAA1151 protein 2 2
130557 H51825 Hs 268911 ESTs Weakly similar to S65824 reverse 2 2
119232 AI655226 Hs 117659 ESTs Weakly similar to T46481 hypotheti 2 2
105715 BE621800 Hs 29444 putative small membrane protein NID67 22
124691 R05835 Hs 110153 ESTs 22
113649 N94768 Hs 16400 ESTs, Weakly similar to KIAA1435 protein 2 2
117040 AW970600 Hs 303261 ESTs 2 2
128767 M85169 Hs 1050 pleckstπn homology, Sec7 and coiled/coi 2 2
120602 AA808018 Hs 109302 ESTs 22
107182 AI311782 Hs 20013 GCIP interacting protein p29 22
107357 U63973 Hs 103501 rhodopsin kinase 22
125499 H10543 gb ym04c06 r1 Soares infant brain 1 NIB H 2 1
126872 AW450979 gb Ul H BI3-ala-a-120-UI s1 NCI_CGAP_Su 2 1
113233 T61955 Hs 279867 CGI-59 protein 2 1
128367 AW611791 Hs 150742 ESTs 2 1
127432 AW067708 Hs 170311 heterogeneous nuclear πbonucleoproteiπ 2 1
114021 AW235215 Hs 16145 ESTs 2 1
104455 AL110261 Hs 157211 DKFZP586B0621 protein 2 1
134966 AW402389 Hs 920 modulator recognition factor I 2 1
129765 M86933 Hs 1238 amelogemn (Y chromosome) 2 1
133461 NM 000762 Hs 334345 cytochrome P450, subfamily HA (phenobar 2 1
109639 AA082650 Hs 6217 Homo sapiens cDNA FU12521 fis, clone NT 2 1
129794 AF161399 Hs 23259 hypothetical protein FLJ13433 2 1
134869 AL157518 Hs 90421 PR02463 protein 2 1
110256 H63947 Hs 237955 RAB7, member RAS oncogene family 2 1
128817 BE395776 Hs 168640 ankylosis, progressive (mouse) homolog 2 1
120906 NM 000734 Hs 97087 CD3Z antigen, zeta polypeptide (TιT3 com 2 1
134354 M90391 Hs 82127 interieukin 16 (lymphocyte chemoattracta 2 1
106048 AW883367 Hs 301732 hypothetical protein MGC5306 2 1
128352 AW137413 Hs 169942 ESTs 2 1
115348 AA281562 Hs 292100 ESTs 2 1
123474 AA599209 gb ag34b11 s1 Jia bone marrow stroma Horn 2 1
107121 AB015427 Hs 250493 zinc finger protein 219 2 1
118509 N22617 Hs 43228 Homo sapiens cDNA FLJ11835 fis clone HE 2 1
135051 AI272141 Hs 83484 SRY (sex determining region Y) box 4 2 1
109442 AW296134 Hs 86999 ESTs Weakly similar to S65657 alpha-1C- 2 1
126661 AA009835 Hs 269521 ESTs 2 1
129270 AA357185 Hs 109918 ras homolog gene family, member H 2 1
125568 AW615396 Hs 105613 ESTs 2 1
132867 AF226667 Hs 58553 CTP synthase II 2 1
124656 AW297702 Hs 102915 ESTs 2 1
128954 AA346839 Hs 209100 DKFZP434C171 protein 2 1
132985 AL045579 Hs 62113 KIAA0717 protein 2 1
119247 BE269047 Hs 65234 hypothetical protein FLJ20596 2 1
106686 N66397 Hs 334825 Homo sapiens CDNA FLJ14752 fis clone NT 2 1
131009 AF169802 Hs 22142 cytochrome b5 reductase b5R 2 2 1
112170 BE246743 Hs 288529 hypothetical protein FLJ22635 2 1
130755 BE293520 Hs 18910 prostate cancer overexpressed gene 1 2 1
117357 N24829 gb yx98h12 s1 Soares melanocyte 2NbHM Ho 2 1
101613 M24283 Hs 168383 intercellular adhesion molecule 1 (CD54) 2 1
127644 N88858 Hs 155101 ATP synthase, H+ transporting mitochond 2 1
101183 AA442324 Hs 795 H2A histone family, member O 2 1
100420 D86983 Hs 118893 Melanoma associated gene 2 1
129879 AK001696 Hs 13109 Ran binding protein 11 2 1
122311 NM 014913 I Hs 131915 KIAA0863 protein 2 1
130566 R85474 Hs 16073 ESTs 2 1
113517 AI874223 Hs 293560 ESTs 2 1
115810 AA426026 Hs 187615 ESTs 2 1
108743 AI580150 Hs 71074 ESTs 2 1
129255 AI961727 Hs 109804 H1 histone family, member X 2 1
120766 AA764879 Hs 12570 tubulin specific chaperone d 2 1
126893 AJ252060 Hs 26320 TRABID protein 2 1
115254 AA279024 Hs 269316 ESTs, Weakly similar to S65657 alpha-1 C 2 1
105865 BE279383 Hs 26557 plakophilm 3 2 1
120999 AI972375 Hs 29626 hypothetical brain protein my038 2 1
125636 H12382 Hs 25119 ESTs, Weakly similar to YEX0 YEAST HYPOT 2 1
117997 N52090 Hs 47420 EST 2 1
104333 D82418 Hs 29626 hypothetical brain protein my038 2 1
134315 AA291183 Hs 81648 hypothetical protein FLJ11021 similar to 2 1
135332 AW393883 Hs 98968 hypothetical protein FLJ23058 2 1
107279 S57296 Hs 323910 v erb-b2 avian erythroblastic leukemia 2 1
133097 W03512 Hs 6479 hypothetical protein MGC13272 2 1
112563 AW961220 Hs 29282 mitogen activated protein kinase kinase 2 1
121782 AW452957 Hs 334698 Homo sapiens, clone MGC 15203, mRNA com 2 1
111567 F12628 Hs 334786 hypothetical protein MGC16040 2 1
133912 H42679 Hs 77522 major histocompatibility complex class 2 1
134076 AF086215 gb Homo sapiens full length insert cDNA 2 1
116665 F04405 gb HSC2SB082 normalized infant brain cDN 2 1
133562 M60721 Hs 74870 H20 (Drosophila) like homeo box 1 2 1
129092 D56365 Hs 63525 poly(rC) binding protein 2 2 1
106869 AW975362 Hs 292679 ESTs 2 1 130820 AL353934 Hs 288798 hypothetical protein FU21012 21
126277 AB037847 Hs 15441 Crm (Cramped Drosophila) like 21
106392 BE350058 Hs 36787 chromodomain helicase DNA binding protei 21
131902 AA180145 Hs 34348 Homo sapiens mRNA, cDNA DKFZp434P0235 (f 21
120734 AA299948 gb EST12544 Uterus tumor 1 Homo sapiens 21
113070 AB032977 Hs 6298 KIAA1151 protein 21
116031 AA452239 Hs 103329 KIAA0970 protein 21
123869 AA620924 Hs 112923 EST 21
106145 AA424791 Hs 5734 meningioma expressed antigen 5 (hyaluron 21
109061 AA160896 gb zo79c07 s1 Stratagene pancreas (93720 21
126348 T16243 Hs 6473 Homo sapiens cDNA FLJ13992 fis, clone Y7 21
133231 AK000517 Hs 6844 hypothetical protein F 20510 21
123132 AI061582 Hs 324179 Homo sapiens cDNA FU12371 fis, clone MA 21
117452 N34687 Hs 44054 ninein (GSK3B interacting protein) 21
128538 R44214 Hs 101189 ESTs 21
111945 R40663 Hs 124944 ESTs 21
119155 R61715 Hs 310598 ESTs Moderately similar to ALU1_HUMAN 21
124362 AL046406 Hs 103483 KIAA1798 protein 21
129198 N57532 Hs 109315 KIAA1415 protein 21
122059 AA431737 Hs 98749 EST, Moderately similar to T42671 hypoth 21
115643 AA404276 Hs 123253 hypothetical protein FLJ22009 20
112558 AK001621 Hs 15921 hypothetical protein FLJ 10759 20
115355 AA262292 Hs 88445 ESTs 20
130724 AK001507 Hs 306084 Homo sapiens clone FLB6914 PR01821 mRNA, 20
125360 AW898892 Hs 189741 ESTs 20
104926 BE298808 Hs 33363 DKFZP434N093 protein 20
119468 AI911535 Hs 6657 hypothetical protein bK1048E95 20
132891 BE267143 Hs 59271 U2(RNU2) small nuclear RNA auxiliary fac 20
100237 D30715 Hs 306333 Human PAP (pancreatitis-associated prot 20
105335 AW291165 Hs 25447 ESTs 20
106727 AA357001 Hs 34045 hypothetical protein FLJ 20764 20
126053 H64450 gb yu62d01 r1 Weizmann Olfactory Epithel 20
115084 BE383668 Hs 42484 hypothetical protein FLJ 10618 20
128408 AI183407 Hs 143704 EST 20
132311 AI765559 Hs 20072 myosm regulatory light chain interactm 20
113626 T94318 Hs 17359 ESTs Moderately similar to RL44_HUMAN 6 20
116379 AA448588 Hs 71252 hypothetical protein DKFZp761C169 20
105474 AL134843 Hs 219614 f box and leucine πch repeat protein 11 20
108922 AA115268 Hs 269263 ESTs 20
123720 AA609734 Hs 112755 EST 20
128902 AA036637 Hs 107052 ESTs 20
113226 AI821008 Hs 10697 ESTs 20
106798 BE252749 Hs 20558 hypothetical protein FLJ 20345 20
106665 BE090009 Hs 323164 hypothetical protein MGC2217 20
105952 AI767152 Hs 181400 ESTs Weakly similar to I78885 senne/th 20
127248 AA364195 gb EST75015 Pineal gland II Homo sapiens 20
112972 AI684745 Hs 165983 hypothetical C2H2 zinc finger protein FL 20
128148 AA918175 Hs 126637 ESTs 20
116176 AA311152 Hs 288708 hypothetical protein FLJ21562 20
126457 AA007489 Hs 50382 ESTs 20
112610 AW500106 Hs 23643 seπne/threonine protein kinase MASK 20
109249 AA194730 Hs 268189 hypothetical protein FLJ 20436 20
121292 AA401807 gb zv65f11 s1 Soares_totaIJetus_Nb2HF8_ 20
128605 AW058113 Hs 102402 Mad4 homolog 20
127705 AJ003322 gb AJ003322 Selected chromosome 21 cDNA 20
134674 AF219139 Hs 87726 KIAA0154 protein ADP πbosylation facto 20
107529 BE515065 Hs 296585 nucleolar protein (KKE/D repeat) 20
116411 AA608897 Hs 321618 hypothetical protein FLJ12525 20
111576 T88827 Hs 15489 ESTs 20
127002 AL353940 Hs 24979 hypothetical protein DKFZp761P1010 20
112662 R85436 Hs 268814 ESTs 20
126250 AL050391 Hs 321247 Homo sapiens mRNA, cDNA DKFZp586A181 (fr 20
101045 J05614 gb Human proliferating cell nuclear anti 20
117186 H98988 Hs 42612 ESTs Weakly similar to ALU1_HUMAN ALU S 20
122110 AI123000 Hs 301240 melanocortin 1 receptor (alpha melanocyt 20
119849 AI074585 Hs 58440 ESTs 20
124395 N29963 Hs 272095 ESTs, Weakly similar to I38022 hypotheti 20
131600 NM_004377 Hs 29331 carnitine palmitoyltransferase I muscle 20
112774 R95770 Hs 35455 ESTs 20
109751 AB033492 Hs 6679 hHDC for homolog of Drosophila headcase 20
102377 U40343 Hs 29656 cyclm-dependent kinase inhibitor 2D (p1 20
115197 R18656 Hs 6749 ESTs 20
102808 BE242818 Hs 179606 nuclear RNA helicase, DECD vanant of DE 20
128869 AA768242 Hs 80618 hypothetical protein 20
111229 AW38984! > Hs 110855 ESTs 20
129330 AL079310 Hs 92260 high mobility group protein 2 like 1 20
105448 NM 001186 Hs 154276 BTB and CNC homology 1, basic leucine zi 20
127391 AW380893 Hs 11039 hypothetical protein MGC2722 20
102337 AI814663 Hs 170133 forkhead box 01 A (rhabdomyosarcoma) 20
121897 AA427419 Hs 229162 EST Weakly similar to ZN91 HUMAN ZINC 20
107902 I AA026627 ' Hs 61358 ESTs 20
12934C I H75334 Hs 11050 F-box only protein 9 20
101097 ' BE245301 Hs 89414 chemokine (C-X C motif), receptor 4 (fus 20 124864 AW970168 Hs 185706 ESTs 20
118485 AA508515 Hs 291049 ESTs 20
116715 AL117440 Hs 170263 tumor protein p53-bιndιng protein, 1 20
130743 AL049266 Hs 18724 Homo sapiens mRNA, cDNA DKFZp564F093 (fr 20
118677 AW971146 Hs 293187 ESTs 20
100020 20
123252 AW968776 Hs 287586 Homo sapiens cDNA FLJ13648 fis, clone PL 20
134977 AL044963 Hs 306121 leukocyte receptor cluster (LRC) encoded 20
115334 AA702972 Hs 65300 ESTs 20
111790 AW769683 Hs 6734 ESTs, Weakly similar to S26650 DNA-bmdi 20
129101 NM 013403 Hs 108665 zinediπ 20
132676 N92589 Hs 261038 ESTs, Weakly similar to I38022 hypothet 20
111018 AI287912 Hs 3628 itogen-activated protein kinase kinase 20
105933 AF078544 Hs 194686 solute earner family 25 (mitochondπal 20
110679 AA004798 Hs 108311 ESTs, Weakly similar to T00351 hypotheti 20
120861 AA350394 Hs 96952 ESTs 20
132430 AW973652 Hs 283105 ESTs 20
115026 AA251972 Hs 188718 ESTs 20
128660 AA011597 Hs 177398 ESTs 20
134554 AI184316 Hs 85273 retinoblastoma-bmding protein 6 20
109592 AI198059 Hs 26370 ESTs 20
123636 AA609263 gb af13c08 s1 Soares_testιs_NHT Homo sap 20
132610 AA160511 Hs 5326 ammo acid system N transporter 2, porcu 20
122652 AA454641 gb zx99d05 s1 Soares NhHMPu S1 Homosapi 20
120467 AW292562 Hs 187628 ESTs 20
126046 AA804957 Hs 119840 ESTs 20
128179 AW293689 Hs 127116 ESTs 20
123349 AB033042 Hs 29679 cofactor required for Sp1 transcnptiona 20
106208 AK001674 Hs 22630 cofactor required for Sp1 transcnptiona 20
125832 AA628600 Hs 117587 ESTs 20
133317 AC005258 Hs 70830 U6 snRNA-associated Sm like protein LSm7 20
132886 AW978168 Hs 5912 F-box only protein 7 20
127447 AA386192 Hs 193482 Homo sapiens cDNA FLJ11903 fis, clone HE 20
133149 AA370045 Hs 6607 AXIN1 up-regulated 20
120468 AW967675 Hs 96487 ESTs, Highly similar to S08228 πbosomal 20
106487 AI697340 Hs 135265 Homo sapiens clone FLB8436 PR02277 mRNA 20
126770 AI292320 Hs 81361 heterogeneous nuclear πbonucleoprotein 20
120592 AA830664 Hs 143974 ESTs 20
100944 L07518 Hs 159593 mucin 6, gastπc 20
101887 AW967413 Hs 83958 transducin-like enhancer of split 4, horn 20
125324 R07785 gb yf15c06 r1 Soares fetal liver spleen 20
133906 BE386038 Hs 77492 heterogeneous nuclear nbonucleoprotein 20
113408 NM 005908 Hs 115945 mannosidase, beta A, lysosomal 20
115613 AW136951 Hs 173946 hypothetical protein FU 10486 20
107468 AA740979 Hs 91389 ESTs 20
100554 M95923 gb Human 12-lιpoxygenase mRNA, partial c 20
120476 NM 014922 Hs 104305 death effector filament-forming Ced-4-lι 20
117160 AA322302 Hs 183302 PCTAIRE protein kinase 2 20
115582 AW245047 Hs 136164 cutaneous T-cell lymphoma-associated tu 20
125536 F08266 Hs 77948 ESTs, Weakly similar to ALU1_HUMAN ALU S 20
100842 U05597 gb Human anion exchanger 3 cardiac isofo 20
133207 AI561173 Hs 67688 ESTs 20
122053 A1637498 Hs 98745 ESTs 20
121080 AA617830 Hs 28310 ESTs 20
113316 T70318 Hs 268581 ESTs 20
113137 AW952129 Hs 293225 ESTs, Weakly similar to FLDED-1 [H sapie 1 9
100416 AW505086 Hs 196914 minor histocompatibility antigen HA-1 1 9
133975 C18356 Hs 295944 tissue factor pathway inhibitor 2 1 9
103872 AI816078 Hs 21756 translation factor suι1 homolog 1 9
132439 AK001942 Hs 4863 hypothetical protein DKFZp566A1524 1 9
126082 H81188 Hs 269571 ESTs 1 9
124677 R01073 gb ye84c03 s1 Soares fetal liver spleen 1 9
123385 BE149685 Hs 17767 KIAA1554 protein 1 9
103138 X65965 gb H sapiens SOD-2 gene for manganese su 1 9
104867 AA278898 Hs 225979 hypothetical protein similar to small G 1 9
128668 AI754363 Hs 103422 Homo sapiens cDNA FLJ14630 fis, clone NT 1 9
125826 M20681 Hs 7594 solute earner family 2 (facilitated glu 1 9
113701 T97301 Hs 18026 ESTs 1 9
134447 M58603 Hs 83428 nuclear factor of kappa light polypeptid 1 9
128895 AW467000 Hs 106985 ESTs 1 9
112719 AI200957 Hs 19301 Homo sapiens, Similar to Nedd-4-lιke ubi 1 9
102552 NM 005426 Hs 44585 tumor protein p53-bιndιng protein, 2 1 9
131186 Z70200 Hs 246112 KIAA0788 protein 1 9
133347 BE257758 Hs 71475 acid cluster protein 33 1 9
133388 AW245631 Hs 182447 heterogeneous nuclear πbonucleoprotein 1 9
112266 AI652534 Hs 25934 ESTs, Weakly similar to HSHU11 histone H 1 9
100336 N76101 Hs 8127 KIAA0144 gene product 1 9
113479 AI023133 Hs 10739 ESTs 1 9
135231 BE613615 Hs 74280 hypothetical protein FLJ22237 1 9
123783 AA610112 gb af19g05 s1 Soares_total_fetus_Nb2HF8_ 1 9
113016 NM 014007 Hs 127649 KIAA0414 protein 1 9
132761 AI815537 Hs 323502 nuclear RNA export factor 1 1 9
128536 AW955065 Hs 101150 Homo sapiens, clone IMAGE 4054156, mRNA, 1 9 126663 AW518478 Hs 181297 ESTs
103973 AA305729 Hs 18272 ammo acid transporter system A1
106742 AW591428 Hs 27556 hypothetical protein FLJ22405
129793 AW207000 Hs 126857 Homo sapiens cDNA FLJ 12936 fis, clone NT
105888 AW970672 Hs 9247 protein kinase, AMP-activated, alpha 1 c 19
101892 AI825838 Hs 75206 protein phosphatase 3 (formerly 2B), cat 19
125511 AJ271379 Hs 76194 πbosomal protein S5 19
126751 AI378328 Hs 77256 enhancer of zeste (Drosophila) homolog 2 19
129111 AL080155 Hs 226372 DKFZP434J154 protein 19
128750 T80270 Hs 104788 hypothetical protein L0C55565 19
133531 BE276738 Hs 74578 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 19
125704 R55094 Hs 26239 Human DNA sequence from clone RP11-438B2 19
100157 D14661 Hs 119 Wilms' tumour 1-assocιatιng protein 19
125845 AK001440 Hs 131840 hypothetical protein FLJ10578 19
134682 AW882645 Hs 88044 sprouty (Drosophila) homolog 1 (antagoni 19
106565 NM 014892 Hs 227602 KIAA1116 protem 19
106706 AB037810 Hs 18760 KIAA1389 protein 19
125761 R68351 gb yh99b03 r1 Soares placenta Nb2HP Homo 19
116470 AI272141 Hs 83484 SRY (sex determining region Y)-box 4 19
123264 AI681270 Hs 99824 BCE-1 protein 19
126096 F08208 Hs 283844 similar to rat tπcarboxylate ca er-lι 19
104995 AK001690 Hs 16390 hypothetical protein FU10035 19
133424 AA350994 Hs 20281 KIAA1700 19
132450 AA100012 Hs 48827 hypothetical protein FLJ 12085 19
131803 U73737 Hs 284289 vitiligo-associated protein VIT-1 19
116548 D20433 gb HUMGS01407 Human promyelocyte Homo sa 19
113815 AA386192 Hs 193482 Homo sapiens cDNA FLJ11903 fis, clone HE 19
100245 AL039248 Hs 3094 KIAA0063 gene product 19
113677 Z70200 Hs 246112 KIAA0788 protein 19
134470 X54942 Hs 83758 CDC28 protein kinase 2 19
134937 AI251449 Hs 171939 ESTs 19
134506 AW247364 Hs 84285 ubiquitin-conjugatmg enzyme E2I (homolo 19
126469 BE384361 Hs 182885 ESTs, Weakly similar to JC5024 UDP-galac 19
115261 AA938293 Hs 60088 hypothetical protein MGC11314 19
125198 W69474 Hs 323140 ESTs 19
115317 AA303799 Hs 300141 πbosomal protein L39 19
112342 AW410273 Hs 92614 longevity assurance (LAG1, S cerevisiae 19
117329 AA524065 Hs 93670 Homo sapiens cDNA FU22664 fis, clone H 19
116353 AB032966 Hs 131728 KIAA1140 protein 19
114459 AW445217 Hs 103362 ESTs 19
133903 X63692 Hs 77462 DNA (cytosine 5-)-methyltransferase 1 19
116083 AA455706 Hs 44581 heat shock protein hsp70-related protein 19
130037 AI498631 Hs 111334 ferntm, light polypeptide 19
102273 BE391815 Hs 75981 ubiquitin specific protease 14 (tRNA-gua 19
120452 AL022328 Hs 104335 hypothetical protein IMAGE3510317 19
116432 BE271922 Hs 71243 ESTs, Weakly similar to zinc finger prot 19
115916 AI052731 Hs 91910 ESTs 19
120827 AA382525 Hs 132967 Human EST clone 122887 manner transposo 19
129602 AI282193 Hs 198298 v-src avian sarcoma (Schmidt-Ruppm A-2) 19
105693 BE250951 Hs 181368 U5 snRNP-specifio protein (220 kD), orth 19
102316 U34301 gb Human nonmuscle myos heavy chain II 19
131422 AW607731 Hs 26670 Human PAC clone RP3-515N1 from 22q11 2-q 19
128434 AI190914 Hs 143880 ESTs 19
117086 AA581602 Hs 41840 ESTs 19
102006 AL048967 Hs 172207 non POU domain containing, octamer bmdi 19
121335 AA404418 gb zw37e02 s1 Soares total fetus Nb2HF8 19
105905 AA401533 Hs 19440 ESTs 19
125165 W45350 gb zc81h08 s1 Pancreatic Islet Homo sapi 19
109875 H03260 Hs 30385 ESTs 19
109152 AW380723 Hs 73451 ESTs, Weakly similar to S55024 nebulm, 19
126203 AK001035 Hs 130881 B-cell CLL/lymphoma 11A (zinc finger pro 19
122530 AW959741 Hs 40368 adaptor-related protein complex 1, sigma 19
124506 BE273688 Hs 182447 heterogeneous nuclear πbonucleoprotein 19
130525 AA361850 Hs 322149 Human clone 137308 mRNA, partial eds 19
127226 AL036559 Hs 3463 πbosomal protein S23 19
106465 AA971576 Hs 225951 topoisomerase-related function protein 4 19
106970 AA521368 Hs 24252 ESTs 19
134275 AI878910 Hs 3688 cisplatin resistance-associated overexpr 19
126825 AA100230 gb zl81c01 s1 Stratagene colon (937204) 19
132443 AW246148 Hs 268371 hypothetical protein FLJ20274 18
104631 AA002064 Hs 18920 ESTs 18
111468 H62647 Hs 205481 ESTs 18
114317 AA524839 Hs 469 succinate dehydrogenase complex, subunit 18
126158 N55989 Hs 16390 hypothetical protein FLJ 10035 18
113782 AK001567 Hs 311002 Homo sapiens cDNA FLJ10705 fis, clone NT 18
119229 T03229 gb FB5C2 Fetal brain, Stratagene Homo sa 18
105930 AF016371 Hs 9880 peptidyl prolyl isomerase H (cyclophilin 18
127245 AA323958 gb EST26810 Cerebellum II Homo sapiens c 18
100967 BE011845 Hs 251064 high mobility group (nonhistone chromoso 18
105149 BE089288 Hs 8958 Homo sapiens cDNA FU 12024 fis, clone HE 18
104542 R29657 gb F1-1179D 22 week old human fetal live 18
124236 AF086006 gb Homo sapiens full length insert cDNA 18
127155 AA284993 gb zt23e10 r1 Soares ovary tumor NbHOT H 18 126854 AJ275986 Hs.71414 transcription factor (SMIF gene) 1.1
107021 AK001342 Hs.14570 hypothetical protein FLJ22530 1.1
110023 AW294701 Hs.31040 ESTs 1.1
114899 AK000342 Hs.77646 Homo sapiens mRNA; cDNA DKFZp761M0223 (f 1.1
127315 AF116622 gb:Homo sapiens clone FLB4217 mRNA seque 1.1
110384 H45282 Hs.268798 ESTs 1.1
132693 BE244200 Hs.55075 KIAA0410 gene product 1.1
127684 AA668631 Hs.32556 KIAA0379 protein 1.1
127297 AW629485 Hs.140720 GSK-3 binding protein FRAT2 1.1
104249 AF004231 Hs.22405 leukocyte immunoglobulin-like receptor, 1.1
112652 BE269699 Hs.235782 solute carrier family 21 (organic anion 1.1
110312 BE256986 Hs.11896 hypothetical protein FLJ12089 1.1
100417 NM 014003 Hs.78054 pre-mRNA splicing factor similar to S. c 1.1
120532 AA262354 Hs.186648 ESTs, Weakly similar to 138022 hypothec 1 ,l
127629 AA293279 Hs.29173 hypothetical protein FU20515 1.1
100739 M59287 Hs.2083 CDC-like kinase 1 1.1
110636 H72868 Hs.19110 ESTs 1.1
132957 BE244044 Hs.61469 hypothetical protein 1.1
115467 AI366784 Hs.48820 TATA box binding protein (TBP)-associate 1.;
132161 W31634 Hs.180799 hypothetical protein FLJ22561 1.1
129510 AW968504 Hs.123073 CDC2-related protein kinase 7 1.:
126805 F32658 Hs.101359 chromosome 6 open reading frame 32 1.J
129295 U63127 Hs.110121 SEC7 homolog 1.;
127823 AW972893 Hs.78869 transcription elongation factor A (Sll), 1.ι
104590 AW373062 Hs.83623 nuclear receptor subfamily 1, group 1, m 1;
111959 R40978 Hs.271498 ESTs, Moderately similar to ALU1 HUMAN A 1.ι
109303 AA199857 Hs.269291 ESTs 1.,
112501 AA972447 Hs.288833 Homo sapiens mRNA; cDNA DKFZp434K087 (fr 1.;
127303 AA366951 gb:EST77963 Pancreas tumor III Homo sapi 1..
115982 W92113 gb:zh48e01.r1 Soares_fetalJiver_spleen_ 1;
123331 AA497013 gb;ae32g02.s1 GesslerWilms tumor Homos 1.
111598 R11505 Hs.268912 ESTs 1.;
121643 AA640987 Hs.193767 ESTs 1.
105012 AF098158 Hs.9329 chromosome 20 open reading frame 1 1..
118761 AW799109 Hs.226755 ESTs 1.
128765 AF073310 Hs.143648 insulin receptor substrate 2 1.
118103 AA401733 Hs.184134 ESTs 1.
134595 NM 002401 Hs.29282 mitogen-activated protein kinase kinase 1.
134212 AA654353 Hs.17719 EBP50-PDZ interactorof 64 D 1,
128033 AI248705 Hs.149321 ESTs 1.
126972 NM 016255 Hs.95260 Autosomal Highly Conserved Protein 1.
111122 N63753 Hs.16492 DKFZP564G2022 protein 1.
114798 AA159181 Hs.54900 serologically defined colon cancer antig 1.
106349 AW954310 Hs.127270 KIAA1545 protein 1.
135358 BE622827 Hs.99486 hypothetical protein FLJ13044 1.
116223 AF045458 Hs.47061 unc-51 (C. elegans)-like kinase 1 1.
116654 Z26324 Hs.79204 ESTs, Weakly similar to I38022 hypolheti 1.
124554 N65961 gb:za27d03.s1 Soares fetal liver spleen 1.
120259 AW014786 Hs.192742 hypothetical protein FLJ12785 1.
123044 AK001035 Hs.130881 B-cell CLL/lymphoma 11 A (zinc finger pro 1.
125261 W90351 Hs.110134 ESTs, Highly similar to CREB-binding pro 1.
135026 N92165 Hs.93231 ESTs 1.
129951 AL110282 Hs.268024 Homo sapiens, clone IMAGE.3873720, mRNA 1.
125768 AI557486 Hs.119122 ribosomal protein L13a 1.
114122 R46128 Hs.12751 ESTs 1.
133047 AA310600 Hs.63657 peptide:N-glycanase similar to yeast PNG 1.
133589 L37368 Hs.75104 RNA-biπding protein SI, serine-rich do a 1.
130872 U61084 Hs.226307 phorbolin (similar to apolipoprotein B m 1.
133498 BE299587 Hs.85301 calcium binding protein P22 1.
131144 AA305255 Hs.23528 HSPC038 protein 1.
104261 AW248364 Hs.5409 RNA polymerase I subunit .
115507 AI083668 Hs.50601 hypothetical protein MGC10986 1.
109073 T05003 Hs.10056 hypothetical protein FLJ14621 1.
115363 AA214618 Hs.152759 xtivator of S phase kinase 1.
112657 AW844878 Hs.19769 hypothetical protein MGC4174 1.
102960 AI904738 Hs.76053 DEAD/ H (Asp-Glu-Ala-Asp/His) box polypep 1.
125549 R20215 gb:yg 18b09.r1 Soares infant brain 1 NIB H 1.
133797 AL133921 Hs.76272 retinoblastoma-biπding protein 2 1.
125048 AW440068 Hs.59425 hypothetical protein FLJ23323 1.
103403 X95406 gb.H.sapiens cyclin E gene. 1.
123546 AA608817 Hs.112597 EST 1.
124694 R06108 gb:ye94h05.s1 Soares fetal liver spleen 1.
102406 U43177 (NONE) 1.
130695 T97205 Hs.17998 ESTs, Weakly similar to 2109260A B cell 1.
123951 A8012922 Hs.173043 metastasis-associated 1-like 1 1.
118533 N71861 Hs.49413 ESTs 1.
123197 AA489250 gb:aa57h12.s1 NCI_CGAP_GCB1 Homo sapiens 1.
125656 AW516428 Hs.78687 neutral sphingomyelinase (N-SMase) activ 1.
100154 H60720 Hs.81892 KIAA0101 gene product 1.
106876 N52821 Hs.269412 ESTs, Moderately similar to ALU7_HUMAN A 1.
128339 AL121087 Hs.296406 KIAA0685 gene product 1.
105939 AL137728 Hs.12258 Homo sapiens mRNA; cDNA DKFZp434B0920 (f 1.
102495 NM_006762 ! Hs.79356 Lysosomal-associated ultispaπniπg embr 1. 100221 028383 gb Human mRNA for ATP synthase B chain, 1 8
101741 NM 003199 Hs 326198 transcπption factor 4 1 8
101701 NM_002436 Hs 1861 membrane protein, palmitoylated 1 (55kD) 1 8
107119 AI375499 Hs 27379 ESTs 1 8
134362 U47742 Hs 82210 zinc finger protein 220 1 8
127964 F06298 gb HSC13F081 normalized infant brain cDN 1 8
101437 M20681 Hs 7594 solute earner family 2 (facilitated glu 1 8
106204 AA188734 Hs 21479 ubinuclem 1 1 8
112716 AW590680 Hs 110802 von Willebrand factor 1 8
109779 AB029396 Hs 3353 beta-1,3-glucuronyltransferase 1 (glucur 1 8
111369 AA535740 Hs 170263 tumor protein p53-bιndιng protein, 1 1 8
135204 AF067515 Hs 183418 cell division cycle 2 like 1 (PITSLRE pr 1 8
105788 AB009698 Hs 23965 solute earner family 22 (organic anion 1 8
110997 AW862823 Hs 168052 KIAA0421 protein 1 8
111620 R14853 Hs 307478 EST, Weakly similar to 139058 hypotheti 18
115618 H11695 Hs 322901 disrupter of silencing 10 1 8
115904 AI167560 Hs 61297 ESTs 1 8
107510 BE613332 Hs 132055 ESTs, Weakly similar to GNMSLL retroviru 1 8
116435 AA186761 Hs 334812 hypothetical protein DKFZp586K0717 1 8
112399 R60920 Hs 296770 KIAA1719 protein 1 8
127426 AA854756 Hs 124076 ESTs 1 8
125175 W52355 Hs 303030 EST 1 8
132972 AA034365 Hs 288924 Homo sapiens cDNA FLJ 11392 fis, clone HE 1 8
125982 R98091 gb yr30e11 r1 Soares fetal liver spleen 1 8
115620 AA399997 Hs 211610 CUG tπplet repeat, RNA-bmding protein 1 8
128115 AI435590 Hs 130168 ESTs 1 8
106880 AI493206 Hs 32425 ESTs 17
101199 L22075 Hs 1666 guanine nucleotide binding protein (G pr 1 7
104159 BE386983 Hs 283685 hypothetical protein FLJ20396 1 7
101368 M13058 Hs 73952 prolme-πch protein Haelll subfamily 2 1 7
103646 AW248439 Hs 2340 junction plakoglob 1 7
130717 AA334274 Hs 18368 DKFZP56480769 protein 1 7
124981 N25485 Hs 330310 maternal G10 transcript 1 7
124770 AA984414 Hs 120429 ESTs 1 7
126926 AA179472 Hs 832 ESTs, Highly similar to A41029 integrin 1 7
101636 BE392781 Hs 89474 ADP-πbosylation factor 6 1 7
123553 AI494291 Hs 111977 ESTs 1 7
127172 AA292208 Hs 251278 KIAA1201 protein 1 7
130621 AW513087 Hs 16803 LUC7 (S cerevisiae) like 1 7
116925 H73110 Hs 260603 ESTs, Moderately similar to A47582 B-ce 1 7
108845 AW362901 Hs 68864 ESTs, Weakly similar to phosphalidylseπ 1 7
128092 AA904617 Hs 166229 ESTs 1 7
128193 AJ224442 Hs 155020 putative methyltransferase 1 7
113965 AI268666 Hs 19631 ESTs, Weakly similar to I38022 hypotheti 1 7
106620 D52562 Hs 296317 KIAA1789 protein 17
102926 W28363 Hs 239752 nuclear receptor subfamily 2, group F, m 1 7
114964 BE085271 Hs 8834 nng finger protein 3 1 7
101800 NM_006433 Hs 105806 granulysm 1 7
130094 NM_001471 Hs 167017 gamma-ammobutyπc acid (GABA) B recepto 1 7
120112 AA180240 Hs 6083 Homo sapiens cDNA FU21028 fis, clone C 1 7
109978 H09356 Hs 22528 ESTs 1 7
121252 AA393907 Hs 97179 ESTs 1 7
127768 AW085002 Hs 156187 ESTs 1 7
125445 AI452722 Hs 7709 WW domain binding protein 1 1 7
100052 1 7
119863 AA081218 Hs 58608 Homo sapiens cDNA FLJ14206 fis, clone NT 1 7
134333 AW888411 Hs 81915 leukemia-associated phosphoprotein p18 ( 1 7
123541 AW976511 Hs 112592 ESTs 1 7
134191 W26632 Hs 7979 KIAA0736 gene product 1 7
103305 X82279 gb H sapiens Fas, Apo-1 gene (promoter a 1 7
112411 R43090 Hs 271510 ESTs, Moderately similar to ALU1_HUMAN A 1 7
100598 AL121734 Hs 146409 cell division cycle 42 (GTP-binding prot 1 7
113610 T93279 gb ye25f01 s1 Stratagene lung (937210) H 1 7
105593 AA279341 Hs 174151 aldehyde oxidase 1 1 7
125317 Z99348 Hs 112461 ESTs, Weakly similar to I38022 hypotheti 1 7
125956 AK000214 Hs 129014 hypothetical protein FLJ20207 1 7
105105 R61532 Hs 87016 hypothetical protein FLJ22938 1 7
132791 AB029551 Hs 7910 R1NG1 and YY1 binding protein 1 7
116996 H83935 Hs 40535 ESTs 1 7
133335 BE251012 Hs 263812 nuclear distnbution gene C (A nidulans) 1 7
120959 BE247692 Hs 102469 putative nuclear protein 1 7
105621 AL040058 Hs 6375 uncharactenzed hypothalamus protein HT0 1 7
106181 AI803651 Hs 191608 ESTs 1 7
125661 AA491830 Hs 25689 ESTs 1 7
127585 AA604144 Hs 190632 ESTs 17
112035 AI955289 Hs 300759 πbosomal protein L36 1 7
102870 M64437 Hs 234799 breakpoint cluster region 1 7
108039 AA280319 Hs 288840 PR01575 protein 1 7
125898 AK001823 Hs 92287 Homo sapiens mRNA cDNA DKFZp564C2478 (f 1 7
114740 N70103 gb za53e10 s1 Soares fetal liver spleen 1 7
120304 AA192469 Hs 271838 ESTs 1 7
103433 X98001 Hs 78948 Rab geranylgeraπyltransferase, beta subu 1 7
116180 AA463902 Hs 13522 ESTs, Weakly similar to I38022 hypothet 1 7 105269 AF174499 Hs 6764 histone deacetylase 6 1 7
125431 AW851639 Hs 75584 polymyositis/scleroderma autoanligen 2 ( 1 7
133579 X75346 Hs 75074 mitogen-activated protein kinase activat 1 7
105355 AL031447 Hs 26938 Homo sapiens, clone IMAGE 4053044, mRNA, 1 7
129601 AB032964 Hs 115726 KIAA1138 protein 1 7
113739 AA356599 Hs 173904 ESTs 1 7
100840 U04816 Hs 183418 cell division cycle 2-lιke 1 (PITSLRE pr 1 7
122878 AA847744 Hs 99640 ESTs 1 7
119495 BE144608 Hs 55533 ESTs 1 7
125669 R51308 Hs 333256 ESTs, Weakly similar to ALU8 HUMAN ALU 1 7
109891 H04757 Hs 323176 ESTs 1 7
126884 U49436 Hs 286236 KIAA1856 protein 1 7
132977 AA093322 Hs 301404 RNA binding motif protein 3 1 7
101396 BE267931 Hs 78996 proliferating cell nuclear antigen 1 7
104730 AW139789 Hs 16370 Homo sapiens cDNA FLJ11652 fis, clone HE 1 7
102205 BE242291 Hs 197540 hypoxia-mducible factor 1, alpha subum 1 7
112945 AW138458 Hs 20787 Homo sapiens cDNA FLJ21686 fis, clone C 1 7
129902 AA076278 Hs 13277 hypothetical protein FU22054 1 7
107157 AW853745 Hs 286035 hypothetical protein FLJ22686 1 7
133229 AL137480 Hs 6834 KIAA1014 protein 1 7
129912 AF155096 Hs 107213 hypothetical protein FLJ20585 1 7
119811 AW137640 Hs 231444 Homo sapiens, Similar to hypothetical pr 1 7
126323 N77584 Hs 68644 Homo sapiens microsomal signal peptidase 1 7
133134 AF198620 Hs 65648 RNA binding motif protein 8A 1 7
115278 AK002163 Hs 301724 hypothetical protein FLJ11301 1 7
133817 AW578716 Hs 7644 H1 histone family, member 2 1 7
130753 AA205223 Hs 189 phosphodiesterase 4C, cAMP-specific (dun 1 7
107463 AW952022 Hs 315164 hypothetical protein similar to actin re 1 7
121009 NM_001533 Hs 2730 heterogeneous nuclear πbonucleoprotein 1 7
125546 H09950 gb ym01d12 r1 Soares infant brain 1NIB H 1 7
129991 R28386 Hs 179925 ESTs, Weakly similar to ALU8_HUMAN ALU 1 7
119015 N95490 Hs 29700 hypothetical protein FLJ20094 1 7
100058 1 7
116655 AF271732 Hs 68090 bπdging ιntegrator-3 1 7
119898 R93325 Hs 58690 ESTs 1 7
105021 H07960 Hs 306044 CGi-05 protein 1 7
102098 N25485 Hs 330310 maternal GlO transcπpt 1 7
126730 AA442429 gb zv70g02 r1 Soares total fetus Nb2HF8 1 7
113427 T85105 Hs 15471 ESTs 1 7
122317 T85253 Hs 290874 ESTs, Weakly similar to ALU8JHUMAN ALU S 1 7
130503 BE208491 Hs 295112 KIAA0618 gene product 1 7
117348 N24157 gb yx96b12 s1 Soares melanocyte 2NbHM Ho 1 7
127033 AF169301 Hs 9098 sulfate transporter 1 1 7
128554 AW972147 Hs 101395 hypothetical protein MGC11352 1 7
124733 R20547 Hs 100830 ESTs 1 7
106310 R98185 Hs 17240 ESTs 1 7
122638 AL137476 Hs 123609 Homo sapiens mRNA, cDNA DKFZp434l0623 (f 1 7
101075 L03532 Hs 79024 heterogeneous nuclear πbonucleoprotein 1 7
126659 T16245 gb NIB1005R Normalized infant brain, Ben 1 7
127717 F12209 Hs 173380 CK2 interacting protein 1, HQ0024c prate 1 7
105441 N28522 Hs 8935 qumolinate phosphoπbosyltransferase (n 1 7
104188 AA478423 Hs 300870 Homo sapiens mRNA, cDNA DKFZp547M072 (fr 1 7
134750 L29073 Hs 1139 cold shock domain protein A 1 7
106826 BE253927 Hs 24983 hypothetical protein from EUROIMAGE 2021 1 7
113511 T89578 Hs 189740 ESTs 1 7
111070 NM 006201 Hs 171834 PCTAIRE protein kinase 1 1 7
129091 AA056483 Hs 301463 Human Chromosome 16 BAC clone CIT987SK A 1 7
129710 AJ277841 Hs 120963 ELG protein 1 7
132833 U78525 Hs 57783 eukaryotic translation initiation factor 1 7
125775 AW514585 Hs 29205 alpha mtegnn binding protein 63 1 7
113675 T81034 Hs 14841 ESTs 1 7
100487 AU076640 Hs 15243 nucleolar protein 1 (120kD) 1 7
119302 T25725 gb ESTDIR152 CD34+DIRECTIONAL Homo sapie 1 7
128245 AA993101 Hs 170486 ESTs 1 7
130322 NM 014247 ' Hs 154545 PDZ domain containing guanine nucleotide 1 7
135363 AW589601 Hs 119 Wilms' tumour 1-assocιatιπg protein 1 7
125181 R40815 Hs 12396 ESTs, Weakly similar to 2004399A chromos 1 7
132347 BE271016 Hs 169850 ESTs, Weakly similar to T21554 hypotheti 1 7
127206 AW816490 Hs 337508 ESTs 1 7
121880 AW946155 Hs 7750 hypothetical protein AL133206 1 7
125797 H03117 Hs 111497 similar to mouse neuronal protein 156 1 7
114601 AA075566 gb zm88f06s1 Stratagene ovaπan cancer 1 7
126278 AA417302 Hs 63042 DKFZp564J157 protein 1 7
120964 AA398085 Hs 142390 ESTs 1 7
133634 AL035071 Hs 234279 microtubule-associated protein, RP/EB fa 1 7
107025 AA825523 Hs 21255 ESTs, Weakly similar to 138022 hypotheti 1 7
105638 AA493453 Hs 247817 H2B histone family, member A 1 7
135398 M16029 Hs 287270 ret proto-oncogene (multiple endocπne 1 7
115794 AA424900 Hs 112227 membrane associated nucleic acid binding 1 7
102083 T35901 Hs 75117 interieukin enhancer binding factor 2, 4 1 7
100188 AW247090 Hs 57101 mmichromosome maintenance deficient (S 1 7
130868 AB037855 Hs 171917 hypothetical protein FLJ 11085 1 7
110493 AI247707 Hs 36915 ESTs 1 7 115041 AA252457 Hs 86543 ESTs, Moderately similar to T00256 hypot 1 7
128764 AW024282 Hs 104938 hypothetical protein MGC15906 1 7
134065 X78992 Hs 78909 butyrate response factor 2 (EGF-response 1 7
101082 BE616731 Hs 80645 interferon regulatory factor 1 1 7
130945 U20582 Hs 2149 actin like protein 1 7
106974 AI817130 Hs 9195 Homo sapiens cDNA FU13698 fis, clone PL 1 7
126752 AI073373 Hs 326923 EST, Weakly similar to 138022 hypothetic 1 7
133327 AL390127 Hs 7104 Kruppel-like factor 13 1 7
127005 T81309 Hs 251664 insulin like growth factor 2 (somatomedi 1 7
105615 AA281959 Hs 5210 glia maturation factor, gamma 1 7
116295 AA742596 Hs 91216 ESTs, Weakly similar to 2004399A chromos 1 7
111587 AI125867 Hs 20734 ESTs 1 7
104570 AW978870 Hs 131828 ESTs 1 7
134752 BE246762 Hs 89499 arachidoπate 5-lιpoxygenase 1 7
130430 W27893 Hs 150580 putative translation initiation factor 1 7
119244 AW407564 Hs 275865 ribosomal protein S18 17
131152 NM 004380 Hs 23598 CREB binding protein (Rubinstem-Taybi s 1 7
133419 BE242676 Hs 73172 growth factor independent 1 1 7
106542 AA339541 Hs 24956 hypothetical protein FU22056 1 7
116482 AW207000 Hs 126857 Homo sapiens cDNA FLJ12936 fis, clone NT 1 7
132555 AW500131 Hs 171763 CD22 antigen 1 7
125840 AB028986 Hs 12064 ubiquitin specific protease 22 1 7
115416 AA283893 Hs 337079 ESTs 1 7
120041 AA830882 Hs 59368 ESTs 1 7
126295 AI281459 Hs 270114 ESTs 1 7
122528 AA449804 Hs 292154 stromal cell protein 1 7
Table 2B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT number Accession
108451 13766 27 AA079195 AA084955 AA126308 AA084956
124236 46919 1 AF086006 H64722 H65212 H66282
115982 173_2 W92113 AA702794 BE044316 W91984 AA679375 T94184 AA679335 BE503126 AW502118 BE467367 AA584550 AW139964 R93353 AW088477 AI887846 AW502624 W81697 W81696 AA447817 AA447667 F13631 AW268271 AA055366 AW629027 AA677404 AA831618 AH 24782 AA889402 AA765804 AA765530 AA055698 AA594019 AI267368 AA456946 R93354 AF264624 AW668618 AA601493
116665 1394292 1 F04405 BE173130
125165 1852047 1 W45350 W45406
125324 1692163 1 R07785T85948 T86972
126053 1601238 1 H64450 H64464
125499 1562851 1 H10543 R11878
126127 1205826 1 N95428 W24040 AW751366 H81987
125546 356478 1 H09950 R18413 AA570553 AW973425
125549 1702179 1 R20215 R18767
125761 1744008 1 R68351 R68364
127155 200358 1 AA284993 AA478122 AA477923
125957 1583542 1 H41694 H45213
125982 1766315 1 R98091 W92898
127245 226662 1 AA323958 AA370268
127248 227560 1 AA364195 AA325029 AW962050
127262 231725 1 AA828125 AA834883 AA330555
126659 1541209J I T16245 R19694 F13545 H10299 T66048 T65279 H18006
127303 258778 1 AA366951 AA470999 AA469425
127315 37938 1 AF116622 Al 114507 AA640834 AA377999
126730 297653 1 AA442429 T19477
103898 187213 3 AA248884
126872 142696J AW450979 AA136653 AA136656 AW419381 AA984358 AA492073 BE168945 AA809054 AW238038 BE011212 BE011359 BE011367
BE011368 BE011362 BE011215 BE011365 BE011363
112540 1605263 ' I R69751 R70467 H69771 H80879 H80878
127705 966283 2 AJ003322 AJ003324
121335 279548 1 AA404418 AI217248
120734 208882 1 AA299948 AA299949
114620 32062_8 AA642974 AA084223
122652 26401J0 AA454641
123636 genbank AA609263 AA609263
100842 tιgr_HT4398 U05597
116548 genbank_D20433 D20433
123783 genbank_AA610112 AA610112
125032 genbank f74884 T74884
123808 genbank_AA620552 AA620552
102316 entrez U34301 U34301
102406 entrez U43177 U43177
134076 40321J AF086215 W02702 AA284288 W25655
104542 R29657
113119 genbaπk_ T47910 T47910
104799 genbank_. AA029703 AA029703
127964 135151J F06298 R18057
120809 genbank., AA346495 AA346495
113610 genbank_ T93279 T93279
113947 genbaπk_W84768
101045 entrez_J05614 129969 genbank_N57818
117031 geπbank_H88353
101447 entrez_M21305
124540 geπbank_N63232
124554 genbank_N65961
117348 genbank_N24157
117357 genbank_N24829
124677 genbank_R01073
124694 genbank^ROδlOδ
103138 entrez_X65965
103305 entrez_X82279
103392 entrez_X94563
103403 entrez_X95406
119229 genbank_T03229
119302 genbank T25725
126825 430458J AA100230 AA100274
105225 genbank_AA211777
121292 genbank_AA401807
112853 geπbank_T02843 T02843
121387 genbank_AA405854
114601 geπbank_AA075566
100221 eπ.rezj)28383 D28383
123197 genbank_AA489250 AA489250
114740 379876J N N7700110033 NN7700002200 AAWW3383189 AI207469W00935 W00906AA551569AI343637 AA135199
123331 geπbank_AA497013
107794 genbank-.AA019255
100554 tιgr_HT2241 M95923
123423 genbank_AA598484
123474 genbank_AA599209
109061 genbank_AA160896
TABLE 3A About 1346 Genes Up regulated in Acute Lymphocyte Leukemia (ALL) Compared to Normal Adult Hematopoietic Tissues
Table 3A lists about 1346 genes up-regulated in acute lymphooytic leukemia (ALL) compared to normal adult hematopoietic tissues These were selected from 35403 probesets on the Affymetπx£os Hu01 GeneChip array such that the ratio of "average" leukemia to "average" normal adult hematopoietic tissues was greater than or equal to 30 The "average" leukemia level was set to the 85* percentile amongst vaπous ALL samples The "average" normal adult hematopoietic tissue level was set to the 75* percentile amongst vaπous non- malignant hematopoietic tissues In order to remove gene specific background levels of non-specific hybridization, the 10* percentile value amongst the tissues was subtracted from both the numerator and ihe denominator before the ratio was evaluated Pkey Unique Eos probeset identifier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene title
R1 Ratio of leukemia to hematopoietic tissues
Pkey ExAccn UnigenelD Unigene Title R1
129498 AA449789 Hs 75511 connective tissue growth factor 5788
100458 S74019 Hs 247979 pre-B lymphocyte gene 1 4945
133774 X54079 Hs 76067 heat shock 27kD protein 1 4842
102564 U59423 Hs 79067 MAD (mothers against decapentaplegic, Dr 41 49
130650 AB040951 Hs 284208 DKFZP434N161 protein 3588
132922 AF249745 Hs 6066 Rho guanine nucleotide exchange factor 3574
112254 AA852097 Hs 25829 ras-related protein 3328
106706 AB037810 Hs 18760 KIAA1389 protein 3239
101050 AU077324 Hs 1832 neuropeptide Y 3068
102455 U48705 Hs 75562 discoidin domain receptor family, member 2681
101838 BE243845 Hs 75511 connective tissue growth factor 2546
113374 T79925 Hs 269165 ESTs, Weakly similar to ALU1_HUMAN ALU S 2469
134125 NMJ14781 Hs 50421 K1AA0203 gene product 2463
106943 AW888222 Hs 9973 tensm 23 14
130069 AI754813 Hs 146428 collagen, type V, alpha 1 2306
119073 BE245360 Hs 279477 ESTs 2253
130444 M12125 Hs 300772 tropomyosin 2 (beta) 21 96
100420 D86983 Hs 118893 Melanoma associated gene 21 05
114324 AF084481 Hs 26077 Wolfram syndrome 1 (wolframin) 1895
101400 M15990 Hs 194148 v-yes-1 Yamaguchi sarcoma viral oncogene 1846
102759 NM 005100 Hs 788 A kise (PRKA) anchor protein (gravm) 1788
100893 BE245294 Hs 180789 S164 protein 1675
131689 AB012124 Hs 30696 transcπption factor-like 5 (basic helix 1660
106410 AB037787 Hs 26229 neuroligin 2 1651
101304 AA001021 Hs 6685 thyroid hormone receptor interactor 8 1560
131524 AB040927 Hs 301804 KIAA1494 protein 1501
107794 AA019255 gb ze56e10 s1 Soares red N2b4HR Homo 1478
129213 AI146494 Hs 109525 ESTs, Weakly similar to IRX2_HUMAN IROQU 1476
116068 AA328041 Hs 194329 hypothetical protein FU21174 1424
134416 X68264 Hs 211579 melanoma cell adhesion molecule 1406
134545 AI902899 Hs 85155 butyrate response factor 1 (EGF-response 1403
114009 AI248544 Hs 103000 KIAA0831 protein 1393
115110 AK001671 Hs 11387 KIAA1453 protein 1375
130107 AF112977 Hs 172887 phytanoyl-CoA hydroxylase (Refsu diseas 1360
133558 X66945 Hs 748 fibroblast growth factor receptor 1 (fms 1360
100871 T85231 Hs 179661 tubulin, beta 5 1350
101462 AL035668 Hs 73853 bone morphogenetic protein 2 1348
120809 AA346495 gb EST52657 Fetal heart II Homo sapiens 1333 123340 AA504264 Hs 182937 peptidylprolyl isomerase A (cyclophilm 1325
103460 AI021993 Hs 14331 S100 calcium binding protein A13 1325
102460 U48959 Hs 211582 yosin, light polypeptide kise 13 14
100168 H73444 Hs 394 adrenomedullm 1309
115844 AI373062 Hs 332938 hypothetical protein MGC5370 1300
130103 Y13492 Hs 149098 smoolhelin 1292
102407 AW602154 Hs 82143 E74-lιke factor 2 (ets domain traπscπpt 1203
113632 T94907 Hs 188572 ESTs 11 85
118951 NM--000448 Hs 73958 recombition activating gene 1 11 73
100305 NMJ-04941 Hs 171872 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 11 63
109737 AA055415 Hs 13233 ESTs, Moderately similar to A47582 B-cel 11 55
122577 AA829725 Hs 334437 hypothetical protein MGC4248 11 49
115147 AA745781 Hs 38399 hypothetical protein MGC2454 11 40
132303 BE177330 Hs 325093 Homo sapiens cD FU21210 fis, clone C 11 37
103176 AL021154 Hs 76884 inhibitor of D binding 3, domint neg 11 17
108358 M81933 Hs 1634 cell division cycle 25A 11 15
104584 AA704538 Hs 193777 ESTs 11 12
106777 AF037261 Hs 33787 vmexiπ beta (SH3-contaιnιng adaptor mol 11 08
121054 AW976570 Hs 97387 ESTs 1090
119400 T92767 gb ye27d06 s1 Stratagene lung (937210) H 1083
126610 AI911353 Hs 191391 ESTs 1083
134555 U34879 Hs 85279 hydroxysteroid (17-beta) dehydrogese 1 1080
131555 T47364 Hs 278613 interferon, alpha inducible protein 27 1079
130979 NM-.012446 Hs 169833 εingle-stranded-D-bmding protein 1070
113783 AL359588 Hs 7041 hypothetical protein DKFZp762B226 1065
123503 AW975051 Hs 293156 ESTs, Weakly similar to I78885 seπne/th 1060
117031 H88353 gb yw21a02 s1 Morton Fetal Cochlea Homo 1045
100752 T81309 Hs 251664 sulin-like growth factor 2 (somatomedi 1044
102618 AL037672 Hs 81071 extracellular matπx protein 1 1036
113089 T40707 Hs 270862 ESTs 1033
132089 W22007 Hs 39122 hypothetical protein MGC15737 1029
101663 NM 003528 Hs 2178 H2B histone family, member Q 1023
104876 AI933128 Hs 25220 like-glycosyltraπsferase 1023
106370 AF039843 Hs 18676 sprouty (Drosophila) homolog 2 10 18
129406 AB018255 Hs 111138 KIAA0712 gene product 10 18
115354 AA281636 Hs 334827 ESTs 10 13
123077 AA485229 Hs 105649 ESTs 1005
131273 AW206008 Hs 283378 Homo sapiens cD FLJ21778 fis, clone H 995
126177 AW752782 Hs 129750 hypothetical protein FLJ10546 983
133699 BE501689 Hs 75617 collagen, type IV, alpha 2 980
110855 AB007928 Hs 28169 KIAA0459 protein 965
111826 R35975 gb yh91b07 s1 Soares placenta Nb2HP Homo 958
126947 Z40778 Hs 191837 ESTs 950
116674 AI768015 Hs 92127 ESTs 948
129087 AI348027 Hs 108557 hypothetical protein PP1057 946
114837 BE244930 Hs 166895 ESTs 945
120009 AI080491 Hs 93270 ESTs, Moderately similar to S65657 alpha 945
112483 AW969785 Hs 285885 Homo sapiens cD FU11321 fis, clone PL 940
103487 AA743603 Hs 172108 πucleopoπn 88kD 930
105675 AL390083 Hs 271277 hypothetical protein from EUROIMAGE 3636 928
129158 NM 004413 Hs 109 dipeptidase 1 (rel) 923
114394 T34462 Hs 103291 neuπtin 917
133331 Y14487 Hs 738 nbosomal protein L14 911
114787 AA156509 Hs 231892 ESTs, Weakly similar to S65657 alpha-1 C- 910
125502 AW977181 Hs 194718 zinc finger protein 265 903
132325 N37065 Hs 4856 hypothetical protein FLJ12116 901
127968 AA830201 Hs 124347 ESTs 900
114605 AL157423 Hs 306478 Homo sapiens mR, cD DKFZp76100511 (f 893
114875 AA235609 Hs 236443 Homo sapiens mR cD DKFZp564N1063 (f 893
129898 AI672731 Hs 13256 ESTs 889
106263 W21493 Hs 28329 hypothetical protein FLJ14005 889
117130 AA748850 Hs 125830 bladder cancer overexpressed protein 888
105553 AA256756 Hs 31178 ESTs 885
103657 Z73677 gb H sapiens gene encoding plakophilm 1 883
105831 AA329449 Hs 247302 twisted gastrulation 882
106375 AW872878 Hs 289072 hypothetical protein FU22175 880
114518 AW163267 Hs 106469 suppressor of varl (S cerevisiae) 3-lιke 875
123433 AW450922 Hs 112478 ESTs 8 67
134558 NMJ01773 Hs 85289 CD34 antigen 867
115893 AI652127 Hs 8419 ESTs 867
128621 AA032197 Hs 102558 Homo sapiens, clone MGC 5352, mR, comp 860
122798 AW366286 Hs 145696 splicing factor (CC1 3) 858
112554 R71489 Hs 29196 EST 855
129969 N57818 gb yv59d07 s1 Soares fetal liver spleen 853
131558 AA453208 Hs 28726 RAB9, member RAS oncogene family 845
134027 Z97630 Hs 226117 H1 histone family, member 0 845
134138 AB023169 Hs 7935 KIAA0952 protein 843
120030 AI076355 Hs 58694 ESTs 843
101005 NM--005239 Hs 85146 v-ets avian erythroblastosis virus E26 o 833
115423 AI499516 Hs 89303 ESTs 833
104946 AW242407 Hs 73848 carcinoembryonic antigen related cell ad 830
131965 W79283 Hs 35962 ESTs 830
126426 AA125984 gb zn27h06 r1 Stratagene neuroepithelium 828 108886 AW248434 Hs 91521 hypothetical protein 826
107985 T40064 Hs 71968 Homo sapiens mR, cD DKFZp564F053 (fr 825
114239 AL137667 Hs 267445 Homo sapiens R, cD DKFZp434B231 (fr 823
124281 AI333756 Hs 111801 arsete resistance protein ARS2 823
117099 H93699 gb yv16a11 s1 Soares fetal liver spleen 820
119432 AL120247 Hs 40109 KIAA0872 protein 815
115967 AI745379 Hs 42911 ESTs 815
132355 D87942 Hs 46328 fucosyltransferase 2 (secretor status in 813
108339 AW151340 Hs 51615 ESTs, Weakly similar to ALU7_HUMAN ALU S 810
131694 NM_000246 Hs 3076 MHC class II transactivator 805
104897 N33937 Hs 10336 ESTs 803
120266 AI807264 Hs 205442 ESTs, Weakly similar to T34036 hypotheti 803
130404 AI672727 Hs 76753 endoglm (Osler-Rendu-Weber syndrome 1) 800
115729 AA417812 Hs 38775 ESTs 800
127216 AI798703 Hs 143702 ESTs, Weakly similar to S70029 probable 795
131693 AW963776 Hs 110796 SARI protein 793
113107 AI821027 Hs 8429 ESTs 790
122282 BE246331 Hs 98401 Homo sapiens mR full length insert cDN 790
111040 AI435502 Hs 14931 ESTs 790
127987 AI022103 Hs 124511 ESTs 790
125317 Z99348 Hs 112461 ESTs, Weakly similar to 138022 hypotheti 788
105242 AI564857 Hs 27888 ESTs, Weakly similar to seπne/threomne 775
100421 D86985 Hs 79276 KIAA0232 gene product 771
114359 NM-.016929 Hs 283021 chlonde intracellular channel 5 770
119772 AJ250839 Hs 58241 gene for seπne/threoπme protein kise 770
124040 U23752 Hs 32964 SRY (sex determining region Y) box 11 765
134361 BE549343 Hs 82208 acyl Coenzyme A dehydrogese, very long 757
105476 AL117352 Hs 120828 Human D sequence from clone RP5-876B10 755
113289 T66900 Hs 188446 ESTs 750
122707 NMJ02039 Hs 239706 GRB2-assocιated binding protein 1 750
130055 A1566248 Hs 146355 v abl Abelson muππe leukemia viral oπco 749
108766 AF145713 Hs 61490 schwannomm interacting protein 1 745
107957 Z36842 Hs 57548 ESTs 745
123116 AW190412 Hs 183738 PERM, RhoGEF (ARHGEF) and pleckslπn dom 738
123190 AA489212 Hs 105228 EST 738
129574 AA026815 Hs 11463 UMP-CMP kise 738
115274 C01566 Hs 86671 ESTs 735
102571 U60115 Hs 239069 four and a half LIM domains 1 734
116845 AA649530 gb ns44f05s1 NCI_CGAP_Alv1 Homo sapiens 733
134851 AB011124 Hs 90232 KIAA0552 gene product 733
101780 M82882 Hs 154365 E74-lιke factor 1 (ets domain transcript 728
125042 T78906 Hs 269432 ESTs, Moderately similar to ALU1_HUMAN A 728
118472 AL157545 Hs 42179 bromodomain and PHD finger containing 3 725
108700 AA121518 Hs 193540 ESTs, Moderately similar to 2109260A 8 c 723
109411 R98881 Hs 109655 sex comb on midleg (Drosophila) like 1 720
127692 AI021912 Hs 187983 ESTs 718
128501 AL133572 Hs 199009 protein containing CXXC domain 2 718
107727 AA149707 Hs 173091 ubiquitin like 3 714
118089 AI762507 Hs 47878 ESTs 712
106025 AV653785 Hs 173334 ELL-RELATED R POLYMERASE II, ELONGATIO 710
122111 AW593206 Hs 98785 Ksp37 protein 708
119674 W60379 Hs 57773 ESTs 705
126607 W87425 Hs 114688 ESTs 705
121545 AA412442 Hs 98132 ESTs 705
113287 T66847 Hs 194040 ESTs Weakly similar to I38022 hypotheti 703
126672 AA255592 Hs 203631 ESTs, Weakly similar to altertively sp 700
132087 H14486 Hs 3903 Cdc42 effector protein 4, binder of Rho 697
118697 N22706 Hs 43234 ESTs 697
100295 M74782 Hs 172689 interieukin 3 receptor, alpha (low affiπ 695
101188 L20320 Hs 184298 cyclm-depeπdent kise 7 (homolog of Xe 695
121481 AA411931 gb zu03g05 s1 Soares testis NHT Homo sap 695
113003 AW292315 Hs 7215 ESTs 693
101851 BE260964 Hs 82045 midkme (neuπte growth promoting factor 691
113529 A1190741 Hs 177415 Finkel-Biskis-Reilly muππe sarcoma viru 690
132887 AA195831 Hs 273385 guanine nucleotide binding protein (G pr 690
113560 T91015 Hs 268626 ESTs 685
123440 AI733692 Hs 112488 ESTs 683
130390 AA490770 Hs 182382 ESTs 683
133889 U48959 Hs 211582 myosm, light polypeptide kise 683
113573 R89379 Hs 15990 ESTs 680
112453 R63899 Hs 28455 ESTs 678
125221 AA236115 Hs 120785 ESTs 678
134081 AL034349 Hs 79005 protein tyrosine phosphatase, receptor t 677
127610 AA960867 Hs 150271 ESTs, Highly similar to uπmed protein 675
105486 AW449258 Hs 6187 ESTs 675
107796 AA058848 Hs 60797 ESTs 671
132754 AI752244 Hs 75309 eukaryotic translation elongation factor 671
105806 AF206019 Hs 110347 REV1 (yeast homolog) like 670
110837 H03109 Hs 108920 HT018 protein 665
117698 N62293 Hs 45107 ESTs 665
128994 AF205849 Hs 107740 Kruppel like factor 2 (lung) 665
129131 AB026436 Hs 177534 dual specificity phosphatase 10 665
108528 AA650558 Hs 325202 ESTs, Highly similar to GBASJHUMAN GUANI 662 131009 AF169802 Hs 22142 cytochrome b5 reductase b5R 2 661
129389 NM 012445 Hs 288126 spondm 2, extracellular matπx protein 660
125278 AI2Ϊ8439 Hs 129998 enhancer of polycomb 1 659
124667 W24320 Hs 102941 Homo sapiens cD FLJ21531 fis, clone C 659
105640 AA001021 Hs 6685 thyroid hormone receptor iπteractor 8 658
106474 BE383668 Hs 42484 hypothetical protein FLJ10618 658
105808 AI133161 Hs 286131 CGI-101 protein 653
120087 AF186780 Hs 79219 RalGDS like gene, KIAA0959 protein 652
100514 AU076887 Hs 28491 spermidine/spermine I-acetyltransferase 650
108378 AI368460 Hs 74615 platelet-denved growth factor receptor, 650
133350 AI499220 Hs 71573 hypothetical protein FLJ 10074 650
115673 AA406341 Hs 269908 Homo sapiens cD FLJ11991 fis, clone HE 648
133410 Y07847 Hs 73088 RAS related on chromsome 22 648
131281 AA251716 Hs 25227 ESTs 646
105510 Z42047 Hs 283978 Homo sapiens PR02751 mR, complete eds 645
128766 AW160432 Hs 296460 cramofacial development protein 1 645
114530 AA601038 Hs 191797 ESTs, Weakly similar to S65657 alpha-1 C- 643
120120 BE547267 Hs 59791 hypothetical protein MGC13183 640
120593 AA748355 Hs 193522 ESTs 640
125832 AA628600 Hs 117587 ESTs 638
129637 NM 004606 Hs 1179 TATA box binding protein (TBP)-assocιate 638
115302 AL109719 Hs 47578 ESTs 633
126137 AA312594 Hs 99115 hypothetical protein FU20689 630
114465 BE621056 Hs 131731 hypothetical protein FLJ 11099 629
125562 AI494372 Hs 98968 hypothetical protein FLJ23058 629
127380 AF070554 Hs 15535 Homo sapiens clone 24582 mR sequence 626
106956 R06428 Hs 226351 ESTs 625
105962 AW880358 Hs 339808 hypothetical protein FU10120 625
109416 BE268388 Hs 86945 ESTs, Weakly similar to A46010 X-lmked 623
111116 AK002039 Hs 26243 Homo sapiens cD FLJ11177 fis, clone PL 623
127282 AA347158 Hs 185780 ESTs 623
113074 AK001335 Hs 31137 protein tyrosine phosphatase, receptor t 621
101664 AA436989 Hs 121017 H2A histone family, member A 620
103317 X83441 Hs 166091 ligase IV, D, ATP-dependent 620
133894 AW021236 Hs 180433 rTS beta protein 619
109260 AW978515 Hs 131915 KIAA0863 protein 618
112772 AI992283 Hs 35437 ESTs, Moderately similar to I38026 MLN 6 618
132050 AI267615 Hs 38022 ESTs 618
113009 T23699 Hs 7246 ESTs 617
118835 AA535246 Hs 50852 ESTs 616
125626 AI038854 Hs 180789 S164 protein 615
117086 AA581602 Hs 41840 ESTs 614
101960 AL036287 Hs 194662 calponin 3, acidic 613
104488 N56191 Hs 106511 protocadheπn 17 613
127695 AA714731 Hs 291457 ESTs, Weakly similar to heterogeneous π 613
127894 AL121053 Hs 5534 Homo sapiens cD FLJ12961 fis, clone NT 613
113595 T92056 Hs 290240 ESTs, Moderately similar to ALU2_HUMAN A 610
120784 AW752101 Hs 16580 hypothetical protein FLJ 11026 610
115004 AA329340 Hs 4867 mannosyl (alpha-1, 3-)-glycoproteιπ beta- 608
129740 BE165866 Hs 83623 nuclear receptor subfamily 1, group I, m 605
117483 N72185 Hs 44189 ESTs 604
103815 BE245294 Hs 180789 S164 protein 603
122040 AA847758 Hs 111030 ESTs 603
109638 AW977747 Hs 119120 E3 ubiquitin ligase SMURF1 602
112727 T91029 Hs 15069 ESTs 601
120273 AA176688 Hs 269284 ESTs 600
122127 AW207175 Hs 106771 ESTs 600
126046 AA804957 Hs 119840 ESTs 599
119774 AB032977 Hs 6298 KIAA1151 protein 598
106265 AA412176 Hs 236463 Homo sapiens mR, cD DKFZp586l0521 (f 598
111987 NM 015310 Hs 6763 KIAA0942 protein 598
123619 AA602964 gb no97c02 s1 NCI CGAP_Pr2 Homo sapiens 596
128122 AI267491 Hs 160593 ESTs 595
128473 T78277 Hs 100293 O-lmked N-acetylglucosamine (GIcc) tr 595
102283 AW161552 Hs 83381 guanine nucleotide binding protein 11 594
122468 AA448172 Hs 137687 ESTs, Highly similar to K6B1_HUMAN RIBOS 593
101801 M86407 Hs 1216 actinin, alpha 3 593
107059 BE614410 Hs 23044 RAD51 (S cerevisiae) homolog (E coli Re 592
108908 AA136569 Hs 10848 KIAA0187 gene product 590
121470 AA558958 Hs 324751 ESTs 590
131938 AF176085 Hs 34956 neural polypyπmidme tract binding prot 589
109613 H47315 Hs 27519 ESTs 589
109384 AA219172 Hs 86849 ESTs 588
118559 N68456 Hs 49519 ESTs 588
102010 U02687 Hs 385 fms related tyrosine kise 3 586
105921 AA421973 Hs 169119 ESTs, Weakly similar to T25731 hypotheti 585
124298 H91679 gb yv04a07 s1 Soares fetal liver spleen 585
120827 AA382525 Hs 132967 Human EST clone 122887 mariner transpose 584
103331 AI825463 Hs 147996 protein kise, X-linked 582
135052 AL136653 Hs 93675 decidual protein induced by progesterone 580
115219 AA262776 Hs 269314 Homo sapiens cD FLJ14123 fis, clone MA 578
121899 R55341 Hs 50421 KIAA0203 gene product 578
135217 AA453880 Hs 9658 hypothetical protein FLJ11790 577 123973 C14805 gb C14805 Clontech human aorta polyA+ mR 577
112605 R79374 Hs 29852 ESTs 576
110151 H18835 Hs 31608 hypothetical protein FLJ20041 575
129889 AA810932 Hs 131899 ESTs, Weakly similar to T00370 hypotheti 575
102638 U67319 Hs 9216 caspase 7, apoptosis-related cysteine pr 573
121501 AA470687 Hs 104772 ESTs 573
124921 R93082 Hs 332635 ESTs 570
109850 AI150548 Hs 23155 ESTs 570
120594 AW136478 Hs 5094 πng finger protein 10 570
126433 AA325606 gb EST28707 Cerebellum II Homo sapiens c 570
100455 AW888941 Hs 75789 N myc downstream regulated 569
106565 NM_014892 Hs 227602 KIAA1116 protein 568
120912 AA376690 Hs 187650 ESTs 568
127209 AA305023 Hs 81964 SEC24 (S cerevisiae) related gene famil 568
107606 AF207989 Hs 330425 Homo sapiens, Similar to G protein-coupl 567
106597 AI091277 Hs 302634 frizzled (Drosophila) homolog 8 566
102126 AW950870 Hs 78961 protein phosphatase 1, regulatory (iπhib 565
100064 AFFX control -TrpnX-3 563
108758 AA127395 Hs 222414 ESTs 563
101392 NM_002507 Hs 1827 nerve growth factor receptor (TNFR super 561
102211 BE314524 Hs 78776 putative transmembrane protein 560
107427 W26975 Hs 46736 hypothetical protein FLJ23476 560
135175 M91463 Hs 95958 solute earner family 2 (facilitated glu 560
111764 AI420368 Hs 290259 ESTs, Weakly similar to 138022 hypotheti 558
119405 T93865 Hs 91085 ESTs 558
126464 AI990046 Hs 54780 transcnption termition factor, R po 558
133865 AB011155 Hs 170290 discs, large (Drosophila) homolog 5 558
123255 AA830335 Hs 105273 ESTs 557
122861 AA335721 Hs 119394 ESTs 556
112046 AA383343 Hs 22116 CDC14 (cell division cycle 14, S cerevi 555
132906 BE613337 Hs 234896 geminin 555
109001 AI056548 Hs72116 hypothetical protein FLJ20992 similar to 555
115816 BE042915 Hs 287588 Homo sapiens cD FLJ13675 fis, clone PL 555
128401 R01865 Hs 268586 ESTs 553
129296 AI051967 Hs 110122 ESTs 553
120314 T10013 Hs 221040 HBS1 (S cerevιsιae)-lιke 551
132815 AI815189 Hs 57475 sex comb on midleg homolog 1 550
113983 W87415 Hs 55296 HLA-B associated transcπpt-1 550
105002 AA224244 Hs 182704 ESTs Moderately similar to altertivel 549
132025 AA011117 Hs 3745 milk fat globule EGF factor 8 protein 549
110732 AW070838 Hs 174174 KIAA0601 protein 548
112891 T03927 Hs 293147 ESTs, Moderately similar to A46010 X-lin 548
126758 AI559444 Hs 293960 ESTs 548
129426 AF077953 Hs 111323 Protein inhibitor of activated STAT X 547
103217 NM 001841 Hs 73037 canb oid receptor 2 (macrophage) 546
132261 U80743 Hs 306094 tnnucleotide repeat containing 12 545
105586 AA865118 Hs 191538 ESTs 543
109454 AA232255 Hs 295232 ESTs, Moderately similar to A46010 X-lin 543
113063 W15573 Hs 5027 ESTs, Weakly similar to A47582 B-cell gr 543
134092 AA218558 Hs 7905 sorting nexm 9 541
119316 AH 14630 Hs 208334 Homo sapiens cD FLJ21874 fis, clone H 538
108019 AI017773 Hs 249159 adrenergic, alpha-2A-, receptor 538
109421 AW604652 Hs 332442 ESTs 538
111929 AF027208 Hs 112360 prominin (mouse)-lιke 1 538
119718 W69216 Hs 92848 ESTs 538
106154 BE540255 Hs 6994 Homo sapiens cD FLJ22044 fis, clone H 535
108544 W39433 Hs 23971 hypothetical protein DKFZp547N043 535
119580 AL079310 Hs 92260 high mobility group protein 2 like 1 535
126777 AL157491 Hs 145211 Homo sapiens mR, cD DKFZp434K1111 (f 535
112944 H18063 Hs 13254 ESTs 534
103149 NMJ06201 Hs 171834 PCTAIRE protein kise 1 534
132437 AA152106 Hs 4859 cyclm L ania 6a 533
103860 AW976877 Hs 38057 ESTs 533
104865 T79340 Hs 22575 B-cell CLL/lymphoma 6, member B (zinc fi 533
129914 NMJ12421 Hs 13321 rearranged L-myc fusion sequence 533
130309 AF067804 Hs 15423 hypothetical protein HDCMC04P 531
116312 BE379794 Hs 65403 hypothetical protein 530
124191 T96509 Hs 248549 ESTs, Moderately similar to S65657 alpha 528
125583 AA195667 Hs 86022 ESTs 528
130591 N59646 Hs 169745 crumbs (Drosophila) homolog 1 528
116355 AA789133 Hs 88650 ESTs 526
115553 AJ275986 Hs 71414 transcription factor (SMIF gene) 526
122802 AI687303 Hs 285529 G protein-coupled receptor 49 525
128495 NM_005904 Hs 100602 MAD (mothers against decapeπtaplegic, Dr 524
117667 U59305 Hs 44708 Ser-Thr protein kise related to the my 523
127890 AA294934 Hs 293902 ESTs, Weakly similar to ISHUSS protein d 522
134843 AA428520 Hs 90061 progesterone binding protein 521
120968 AA528283 Hs 292737 ESTs 521
102076 BE299197 Hs 179665 cyclin-dependent kise inhibitor 1 A (p2 520
100934 J03019 Hs 99913 adrenergic, beta-1-, receptor 520
112667 BE538516 Hs 15423 hypothetical protein HDCMC04P 520
119304 AW249266 Hs 98493 X ray repair complementing defective rep 520
131868 AW408296 Hs 33532 zinc finger protein 151 (pHZ-67) 520 105914 AW245680 Hs 9701 growth arrest and D damage-inducible, 518
102258 NM 001546 Hs 34853 inhibitor of D binding 4, dom t neg 518
103850 AA187101 Hs 213194 hypothetical protein MGC10895 518
112516 T83909 gb yd67f 10 r1 Soares fetal liver spleen 518
133640 AW246428 Hs 75355 ubiquitin-coπjugatmg enzyme E2N (homolo 5 18
135180 D90070 Hs 96 phorbol 12-myπstate-13-acetate-mduced 5 18
135309 AI564123 Hs 42500 ADP-πbosylation factor-like 5 518
134801 S76825 Hs 89695 insulin receptor 517
133362 AK001519 Hs 7194 CGI-74 protein 517
135206 AB024703 Hs 96334 πng finger protein 11 5 15
111480 R06453 Hs 19706 ESTs 515
118466 N66741 gb yz33g08 s1 Morton Fetal Cochlea Homo 515
125757 AI274906 Hs 166835 ESTs, Highly similar to 1814460A p53-ass 515
127140 AI273507 Hs 303966 ESTs 515
109223 AW000714 Hs 65818 ESTs 5 14
103656 Z73497 Hs 247802 Human D sequence from clone U240C2 on 514
133388 AW245631 Hs 182447 heterogeneous nuclear nbonucleoprotein 512
100511 M76676 Hs 116840 ESTs 510
101941 S77583 gb HERVK10/HUMMTV reverse transcnptase 510
109937 AI084066 Hs 20072 myosm regulatory light chain mteractin 5 10
122996 A1436216 Hs 191715 ESTs, Weakly similar to ZN91 HUMAN ZINC 510
128242 AA992626 Hs 269755 ESTs, Moderately similar to ALU5_HUMAN A 510
112374 NM 016323 Hs 26663 cyclm-E binding protein 1 510
124506 BE273688 Hs 182447 heterogeneous nuclear nbonucleoprotein 510
104216 AB002313 Hs 3989 plexm B2 509
135051 AI272141 Hs 83484 SRY (sex determining region Y) box 4 508
131629 Z45794 Hs 238809 ESTs 508
111722 R23924 Hs 23596 EST 507
107034 AF257770 Hs 20930 poly(rC)-bmdιng protein 4 506
110243 H26683 gb yl14g03 s1 Soares breast 2NbHBst Homo 505
125837 AW968123 Hs 333513 small inducible cytokine subfamily E, me 505
130300 X58288 Hs 154151 protein tyrosine phosphatase, receptor t 505
103967 AL120051 Hs 144700 ephπn-B1 504
112678 AI418466 Hs 33665 ESTs 503
124963 F06600 Hs 101375 Homo sapiens mR, cD DKFZp434H205 (fr 503
131379 AK001123 Hs 26176 hypothetical protein FLJ10261 503
109451 N32264 Hs 44330 ESTs 502
101396 BE267931 Hs 78996 proliferating cell nuclear antigen 502
131038 W87778 Hs 169388 hypothetical protein DKFZp761H2024 501
101208 L25081 Hs 1 9735 ras homolog gene family, member C 501
104973 NM 015310 Hs 6763 KIAA0942 protein 499
103141 X66113 Hs 75584 polymyositis/scleroderma autoantigen 2 ( 498
111260 AB033035 Hs 51965 KIAA1209 protein 498
128142 T67162 Hs 135127 ESTs, Weakly similar to unmed protein 498
113857 AW243158 Hs 5297 DKFZP564A2416 protein 496
105292 AF128542 Hs 166846 polymerase (D directed), epsilon 496
114341 AF270491 Hs 28249 hepatocellular carcinoma-associated anti 495
100615 W32474 Hs 301746 RAP2A, member of RAS oncogene family 495
103208 AW411340 Hs 31314 retinoblastoma binding protein 7 495
121121 AA399371 Hs 189095 similar to SALL1 (sal (DrosophilaJ-like 495
125321 T86652 Hs 178294 ESTs 495
101145 113210 Hs 79339 lectin galactoside binding, soluble, 3 495
100551 M73980 Hs 129053 Homo sapiens NOTCH 1 (N1) mR complete 493
126182 AA721331 Hs 293771 ESTs 493
127925 AA805151 Hs 3628 mitogeπ-activated protein kise kise 493
133969 AA669112 Hs 78 GA-bindmg protein transcπption factor, 493
120873 AA358015 gb EST66864 Fetal lung III Homo sapiens 492
125219 AI804331 Hs 99423 ATP-dependent R helicase 491
102790 BE245277 Hs 154196 E4F transcπption factor 1 490
129486 NM 005754 Hs 220689 Ras-GTPase-activatmg protein SH3-domaιn 490
130381 L47345 Hs 155202 transcnption elongation factor B (Sill) 489
132389 AA310393 Hs 190044 ESTs 488
100260 D38491 Hs 322478 KIAA0117 protein 488
109585 N59650 Hs 27252 ESTs 488
111603 R11529 Hs 20634 EST 488
120514 AA258335 gb zr59b02 s1 Soares_NhHMPu_S1 Homo sapi 488
130314 NM 014674 Hs 154332 KIAA0212 gene product 486
108958 AF1~42482 Hs 203846 TEA domain family member 3 486
126603 W86610 Hs 185736 ESTs 485
100406 AI962060 Hs 118397 AE-bindmg protein 1 485
116238 AV660717 Hs 47144 DKFZP586N0819 protein 484
105288 N99673 Hs 3585 ESTs, Weakly similar to AF126743 1 DJ 483
118753 AA346206 Hs 50471 ESTs, Weakly similar to T14267 Xin prate 482
113070 AB032977 Hs 6298 KIAA1151 protein 481
107908 AF087999 Hs 42826 ESTs 480
119678 AI658666 Hs 6106 R binding motif protein 4 480
100415 D86970 Hs 75822 TGFB1-ιnduced and apoptotic factor 1 479
128360 F12374 gb HSC39B101 normalized infant brain cDN 478
133101 AK000299 Hs 180952 dycdn 4 (p62) 478
103507 AJ000512 Hs 296323 serum/glucocorticoid regulated kise 478
107666 AA010611 Hs 60418 EST 478
108030 AI378523 Hs 62011 ESTs 478
131479 D86181 Hs 273 galactosylceramidase (Krabbe disease) 478 133140 AF180681 Hs 6582 Rho guanine exchange factor (GEF) 12 478
134654 AK001741 Hs 8739 hypothetical protein FLJ10879 478
106288 AB037742 Hs 24336 KIAA1321 protein 476
101524 NM 000448 Hs 73958 recombition acdvating gene 1 475
113095 AA828380 Hs 126733 ESTs 475
114924 AI338053 Hs 87329 HSPC072 protein 475
127543 AK000787 Hs 157392 Homo sapiens cD FU20780 fis, clone CO 475
115866 AW062629 Hs 52081 KIAA0867 protein 475
101382 AU076772 Hs 1279 complement component 1, r subcomponent 4 4
126509 R47400 Hs 23850 ESTs 474
127930 AA809672 Hs 123304 ESTs 473
127824 AI911516 Hs 127811 ESTs 473
110049 H12449 Hs 31159 EST, Weakly similar to ALUB_HUMAN «« A 473
127115 H77859 Hs 65450 reticulon 4 473
104727 N81203 Hs 20047 zinc finger protein, subfamily 2A (FYVE 472
127532 AJ003429 gb AJ003429 Selected chromosome 21 cD 471
127304 AI741577 Hs 99962 proteoglycan 2, bone maπow (tural kil 470
105409 AW505076 Hs 301855 DiGeorge syndrome cπdcal region gene 8 470
114969 AW162998 Hs 24684 KIAA1376 protein 470
115125 AA193588 Hs 85888 ESTs 470
118348 AW408586 Hs 91052 ESTs, Moderately similar to ALU5JHUMAN A 470
123130 AA487200 gb ab19f02 s1 Stratagene lung (937210) H 470
130881 AA809875 Hs 25933 ESTs 470
132074 AA478486 Hs 3852 KIAA0368 protein 470
106897 AF039023 Hs 167496 F!AN binding protein 6 469
131121 AA120865 Hs 23136 ESTs 469
116046 BE395293 Hs 94491 hypothedcal protein FU20297 468
112868 AW388359 Hs 10667 ESTs 468
116877 AA708958 Hs 168732 ESTs 468
131241 BE501914 Hs 24654 Homo sapiens cD FLJ11640 fis, clone HE 468
132027 AF151020 Hs 181444 hypothetical protein 468
133323 BE336654 Hs 70937 H3 histone family, member A 468
114269 AA176769 Hs 23450 mitochondπal πbosomal protein S25 467
122713 AI089443 Hs 99436 ESTs 467
133571 BE515037 Hs 177556 melanoma andgen, family D, 1 466
134453 AI272141 Hs 83484 SRY (sex determining region Y)-box 4 466
115510 BE299339 Hs 72249 three PDZ containing protein similar to 466
115322 L08895 Hs 78995 MADS box transcnpdon enhancer factor 2 466
129315 NM 014563 Hs 174038 spondyloepiphyseal dysplasia late 465
104674 AI935962 Hs 26289 ESTs 465
106276 AA625947 Hs 25750 ESTs 465
108216 AA524743 Hs 44883 ESTs 465
120376 AA227469 gb zr18a07 s1 Stratagene NT2 neurol pr 465
121743 AA397636 gb zt79e09 r1 Soares testis NHT Homo sap 465
128011 AI347067 Hs 124636 ESTs 465
123454 AA868510 Hs 112496 ESTs 464
103409 NMJ.04454 Hs 43697 ets variant gene 5 (ets-related molecule 464
120484 AA253170 Hs 96473 EST 463
127046 AA321948 Hs 293968 ESTs 463
133184 AA001021 Hs 6685 thyroid hormone receptor mteractor 8 463
123184 BE247767 Hs 18166 KIAA0870 protein 462
106627 AK000706 Hs 15125 hypothetical protein FLJ20699 461
115475 AB033085 Hs 40193 hypothetical protein KIAA1259 461
119468 AI911535 Hs 6657 hypothetical protein bK1048E95 459
133662 BE409053 Hs 299629 peroxisomal long-chain acyl-coA thioeste 458
113941 AA531016 Hs 22399 hypothetical protein FLJ14824 458
131590 R46277 Hs 250638 Homo sapiens mR full length insert cDN 458
128795 AA531287 Hs 105805 ESTs 458
116480 C14088 Hs 169476 glyceraldehyde-3-phosphate dehydrogese 458
111713 C75253 Hs 220950 ESTs 458
113721 AF143885 Hs 18190 EST 457
111657 R07364 Hs 268667 ESTs, Weakly similar to ALU1JHUMAN ALU S 456
102009 BE245149 Hs 82643 protein tyrosine kise 9 455
135242 A1583187 Hs 9700 cyclm E1 455
127580 BE548749 Hs 148016 ESTs 455
109785 AB011131 Hs 12376 piccolo (presyptic cytomatπx protein) 453
109700 F09609 gb HSC33H092 normalized infant brain cDN 453
124882 A1698652 Hs 101539 ESTs 453
131765 AW381270 Hs 194110 hypothedcal protein PRO2730 453
115684 NM-.006577 Hs 284284 ESTs, Highly similar to beta-1 ,3-N acety 452
102034 AI903474 Hs 230 fibromodulm 452
109776 R43665 Hs 12257 ESTs 450
111650 R16722 Hs 124246 ESTs 450
132993 AB023154 Hs 62264 KIAA0937 protein 449
129017 AA115333 Hs 107968 ESTs 449
132902 AI936442 Hs 59838 hypothetical protein FLJ10808 448
114814 AB006622 Hs 182536 KIAA0284 protein 448
120839 AA348913 gb EST55442 Infant adrel gland II Homo 448
101434 AV650066 Hs 1430 coagulation factor XI (plasma thrombopla 448
102018 U03398 Hs 1524 tumor necrosis factor (ligand) superfami 448
104619 AA001635 Hs 287414 transcnptiol intermediary factor 1 ga 448
106716 AA931198 Hs 238928 HT002 protein, hypertension related calc 448
126020 H79863 Hs 114243 ESTs 448 119899 AI057404 Hs 58698 ESTs 447
115582 AW245047 Hs 136164 cutaneous T-cell lymphoma-associated tum 446
125695 W22529 Hs 30942 ephrm B2 446
105715 BE621800 Hs 29444 putative small membrane protein NID67 445
117169 R87866 Hs 95120 ESTs, Weakly similar to HZHU hemoglobin 445
102757 AW955454 Hs 30942 ephπn B2 445
120637 AA811804 gb ob39a05 s1 NCI_CGAP_GCB1 Homo sapiens 445
131579 N62922 Hs 29088 ESTs 445
135287 U82670 Hs 9786 zinc finger protein 275 445
112540 R69751 gb yι40a10 s1 Soares placenta Nb2HP Homo 445
125724 AL360190 Hs 295978 Homo sapiens mR full length insert cDN 444
115498 AA291070 gb zs46a08 s1 NCI_CGAP_GCB1 Homo sapiens 443
102263 U29171 Hs 75852 casein kise 1, delta 443
124312 H94647 Hs 102329 ESTs 443
112366 AF035318 Hs 12533 Homo sapiens clone 23705 mR sequence 443
115955 AF263613 Hs 44198 intracellular membrane-associated calciu 443
103562 NM 002702 Hs 2815 POU domain, class 6, transcπpdon facto 442
100169 AL037228 Hs 82043 D123 gene product 440
108928 AA143802 Hs 71781 ESTs 440
125908 AF265555 Hs 250646 baculoviral IAP repeat-containing 6 440
126996 BE161065 Hs 167531 methylcrotoπoyl-Coenzyme A carboxylase 2 440
129512 T88845 Hs 112200 ESTs, Weakly similar to ALU7_HUMAN ALU S 440
134570 U66615 Hs 172280 SWI/SNF related, matπx associated, xd 440
135073 W55956 Hs 94030 Homo sapiens mR, cD DKFZp586E1624 (f 440
105011 BE091926 Hs 16244 mitodc spindle coiled-coil related prot 440
128793 AB011125 Hs 105749 KIAA0553 protein 440
107292 BE166479 Hs 4789 Homo sapiens serologically defined breas 438
126144 H84455 Hs 40639 ESTs 438
130783 X07282 Hs 171495 retinoic acid receptor, beta 438
135192 U83993 Hs 321709 punnergic receptor P2X, ligaπd-gated 438
100284 D43767 Hs 66742 small inducible cytokine subfamily A (Cy 437
117269 N21621 Hs 91142 KH type splicing regulatory protein (FUS 436
104261 AW248364 Hs 5409 R polymerase I subunit 435
108609 BE409857 Hs 69499 hypothedcal protein 435
126319 D81689 gb HUM184E05B Human fetal brain (TFujiwa 435
127445 AA906286 Hs 193942 ESTs 435
130772 BE270640 Hs 19192 cyclm-dependentkιse 2 435
134625 AA977638 Hs 184389 ESTs 435
135397 L14922 Hs 166563 replication factor C (activator 1) 1 (14 435
128070 AA886944 Hs 303908 ESTs 435
135046 AI494054 Hs 93589 hypothetical protein DKFZp564B1162 433
101881 NM 004957 Hs 754 folylpolyglutamate synthase 433
129838 AB007863 Hs 185140 KIAA0403 protein 433
130974 NM 003528 Hs 2178 H2B histone family, member Q 433
107763 AA018220 Hs 106730 chromosome 22 open reading frame 3 432
129818 T71092 Hs 172572 hypothetical protein FLJ20093 431
129407 AL137597 Hs 11114 hypothetical protein dJ1181N3 1 430
110846 BE277343 Hs 297875 endoplasmic reticulum chaperone SIL1, ho 430
111433 R01452 Hs 40193 hypothetical protein KIAA1259 430
114860 AL157545 Hs 42179 bromodomam and PHD finger containing 3 430
115853 AW978561 Hs 191548 ESTs 430
116165 AI184751 Hs 75874 pregncy-associated plasma protein A 430
126911 AA428049 Hs 1501 syndecan 2 (heparan sulfate proteoglycan 430
131230 NM 005865 Hs 274407 protease senne, 16 (thymus) 430
100349 D64110 Hs 77311 BTG family, member 3 429
100175 BE258769 Hs 32500 acetyl-Coenzyme A acyltransferase 2 ( it 429
105335 AW291165 Hs 25447 ESTs 429
122507 BE567620 Hs 99210 ESTs 428
105397 AA814807 Hs 7395 hypothetical protein FLJ23182 428
133674 AW851121 Hs 75497 Homo sapiens cD FU22139 fis, clone H 428
102826 NM 007274 Hs 8679 cytosolic acyl coeπzyme A thioester hydr 428
103272 NM_006680 Hs 2838 malic enzyme 3, DP(+) dependent, mitoc 428
111887 R38635 Hs 12328 KIAA1005 protein 428
120336 N85785 Hs 181165 eukaryotic translation elongation factor 428
133736 D49958 Hs 75819 glycoprotein M6A 428
130356 AF127577 Hs 155017 nuclear receptor interacting protein 1 427
119830 AW054922 Hs 53478 Homo sapiens cD FLJ12366 fis, clone MA 427
106758 AB014564 Hs 22616 KIAA0664 protein 425
109709 F09749 Hs 187405 ESTs 425
110463 H52931 Hs 165067 ESTs 425
124472 N52517 Hs 102670 EST 425
109770 R40322 Hs 248420 ESTs, Moderately similar to A47582 B cel 424
131487 F13036 Hs 27373 Homo sapiens mR, cD DKFZp56401763 (f 423
107216 D51069 Hs 211579 melanoma cell adhesion molecule 423
123562 AA177088 Hs 190065 ESTs 423
125986 W02410 Hs 205555 ESTs 423
126221 N20514 Hs 172965 ESTs 423
127092 T26985 gb NIBT065H01 R Infant brain, LLNL array 423
132349 AW975654 Hs 181286 senne protease inhibitor, Kazal type 1 423
118946 N92834 gb zb67f03 s1 Soares_fetal_lung_NbHL19W 422
101531 AI199711 Hs 576 fucosidase, alpha-L- 1, dssue 421
105322 T87179 Hs 16346 ESTs, Weakly similar to S57447 HPBRII-7 421
104219 AB002323 Hs 7720 dynem, cytoplasmic, heavy polypeptide 1 420 102825 BE262386 Hs 7137 clones 23667 and 23775 zinc finger prote 420
103571 AI675749 Hs 211608 πucleopoπn 153kD 420
106942 AA995351 Hs 31314 retiπoblastoma-biπding protein 7 420
112685 R87650 Hs 33439 ESTs, Weakly similar to ALU1_HUMAN ALU S 420
123107 AA225048 Hs 104207 ESTs 420
132659 Z75190 Hs 54481 low density lipoprotein receptor-related 420
130084 AI929377 Hs 173724 creatine kise, brain 4 19
114553 BE219860 Hs 22505 hypothedcal protein FU10159 4 18
129628 U38945 Hs 1174 cyclm-dependent kise inhibitor 2A (me 4 18
102266 U29725 Hs 3080 mitogen-acdvated protein kise 7 4 18
110637 AI241470 Hs 268982 ESTs 4 18
127520 T51239 gb yb20d12 s1 Stratagene fetal spleen (9 4 18
130322 NM-.014247 Hs 154545 PDZ domain containing guanine nucleotide 4 17
104768 D82319 Hs 11056 RALBP1 protein 4 17
123360 AA532718 Hs 178604 ESTs 4 17
133110 AA808177 Hs 65228 ESTs 4 16
130923 H96115 Hs 21293 UDP-N-acteylglucosamine pyrophosphorylas 4 16
109878 BE620775 Hs 4866 Homo sapiens cD FU14387 fis, clone HE 4 16
119265 BE539706 Hs 285363 ESTs 4 16
124214 H58608 Hs 151323 ESTs 4 15
106193 AA057478 Hs 23272 ESTs 4 15
105169 BE245294 Hs 180789 S164 protein 4 15
132304 AA610002 Hs 44296 hypothedcal protein FU22324 4 15
131600 NM_004377 Hs 29331 carnitine palmitoyltransferase I, muscle 4 14
131365 M93415 Hs 26014 activm A receptor, type II 4 14
121993 AW297880 Hs 98661 ESTs 4 14
110779 AI391472 Hs 12561 ESTs, Highly similar to C212_HUMAN 283 4 13
126383 AB032977 Hs 6298 KIAA1151 protein 413
104446 AF084555 Hs 7351 cyclic AMP phosphoprotein, 19 kD 4 13
131475 AA992841 Hs 27263 KIAA1458 protein 413
128933 NM 002050 Hs 334695 GATA-bindmg protein 2 412
113141 AI493276 Hs 9187 ESTs 411
134833 L20965 Hs 89901 phosphodiesterase 4A, cAMP-specific (dun 4 11
106461 AI630759 Hs 17481 Homo sapiens clone 24606 mR sequence 410
128056 AI990131 Hs 276973 potassium large conductance calcium-acti 4 10
114757 AW970579 Hs 291031 ESTs 4 10
134653 AI765883 Hs 87385 ESTs 409
100472 D90084 Hs 1023 pyruvate dehydrogese (lipoamide) alpha 408
103102 X61177 Hs 68876 interieukin 5 receptor, alpha 408
106779 BE276013 Hs 172364 Homo sapiens mR for FLJ00086 protein, 408
133615 M62843 Hs 75236 ELAV (embryonic lethal, abnormal vision, 408
130178 U20982 Hs 1516 insulin-like growth factor-binding prate 407
124659 AI680737 Hs 289068 Homo sapiens cD FLJ11918 fis, clone HE 407
127861 AW295020 Hs 198529 ESTs 407
112129 AB037715 Hs 183639 hypothetical protein FLJ10210 407
100918 AK001335 Hs 31137 protein tyrosine phosphatase, receptor t 406
124677 R01073 gb ye84c03 s1 Soares fetal liver spleen 405
102722 F13271 Hs 79981 Human clone 23560 mR sequence 405
111117 AB037721 Hs 173871 KIAA1300 protein 405
122506 AA449120 Hs 99209 ESTs 405
126392 AI356294 Hs 3280 caspase 6, apoptosis-related cysteme pr 405
130760 AW379130 Hs 18953 phosphodiesterase 9A 405
104220 AB002324 Hs 301094 KIAA0326 protein 405
112774 R95770 Hs 35455 ESTs 404
111128 AW505364 Hs 19074 LATS (large tumor suppressor, Drosophila 404
113146 BE151985 Hs 5722 hypothedcal protein FLJ23316 404
124940 AF068846 Hs 103804 heterogeneous nuclear nbonucleoprotein 403
105498 H68279 Hs 24937 transformer-2 alpha (htra-2 alpha) 403
112631 R82040 gb yj06b06 s1 Soares placenta Nb2HP Homo 403
118244 N62516 Hs 48556 ESTs 403
118720 N73515 gb za49d07 s1 Soares fetal liver spleen 403
129232 R98881 Hs 109655 sex comb on midleg (Drosophila) like 1 403
134192 H01345 Hs 24139 Homo sapiens cD FLJ23137 fis, clone L 403
131893 BE336886 Hs 3416 adipose differentiation-related protein 402
116793 T77781 gb yd20a11 s1 Soares fetal liver spleen 402
125674 AL036166 Hs 323378 coated vesicle membrane protein 401
116640 X89984 Hs 211563 B-cell CLL/lymphoma 7A 401
105057 AA134233 Hs 336942 Homo sapiens cD FLJ21488 fis, clone C 400
105158 AW976357 Hs 234545 hypothedcal protein NUF2R 400
116245 AB033107 Hs 42796 KIAA1281 protein 400
119946 AA932283 Hs 58925 ESTs 400
121975 AA740679 Hs 98631 ESTs 400
132037 AA352702 Hs 332541 Homo sapiens, Similar to RIKEN cD 2700 400
133669 NM 006925 Hs 166975 splicing factor, argiπine/seπne πch 5 400
109468 NMJ15310 Hs 6763 KIAA0942 protein 399
106829 AW959893 Hs 27099 hypothetical protein FLJ 23293 similar to 399
134682 AW882645 Hs 88044 sprouty (Drosophila) homolog 1 (antagoni 398
105966 AA142984 Hs 5344 adaptor-related protein complex 1, gamma 3 98
100448 AF234887 Hs 57652 cadheπn, EGF LAG seven-pass G-type rece 398
102589 AU076728 Hs 8867 cysteine-πch, angiogenic mducer, 61 398
104146 AW880614 Hs 146381 R binding modf protein, X chromosome 398
111465 AI968256 Hs 15470 putadve πng zinc finger protein NY-REN 398
126499 AK001779 Hs 110445 CGI-97 protein 398 134388 AW405434 Hs 82575 small nuclear nbonucleoprotein polypept 398
105564 BE616694 Hs 288042 hypothetical protein FU14299 397
115206 AW183695 Hs 186572 ESTs 396
103853 AF272390 Hs 111782 myos 5C 396
110542 H58373 Hs 332938 hypothetical protein MGC5370 396
106797 AI768801 Hs 169943 Homo sapiens cD FU13569 fis, clone PL 396
130589 AL110226 Hs 16441 DKFZP434H204 protein 395
122788 AI828638 Hs 99514 hypothetical protein FLJ20574 395
104518 H20816 Hs 112423 Homo sapiens mR, cD DKFZp586l1420 (f 395
130640 NM 004753 Hs 17144 short-chain dehydrogese/reductase 1 395
110847 N30169 Hs 279807 ESTs, Weakly similar to 2004399A chromos 395
116156 AA461045 Hs 50701 ESTs 395
122096 AA431162 Hs 98690 ESTs 395
122160 AI769281 Hs 97439 ESTs 395
123930 AA740878 Hs 112982 ESTs 395
126280 219417 gb HSB26B122 STRATAGENE Human skeletal m 395
126547 U47732 Hs 84072 transmembrane 4 superfamily member 3 395
134757 AA913267 Hs 211576 IL2-ιnducιble T-cell kise 395
117296 AL133427 Hs 42506 Homo sapiens R full length insert cDN 395
112261 AL050297 Hs 300861 ESTs, Highly similar to T08701 hypothed 395
112268 W39609 Hs 22003 solute earner family 6 (neurotransmitte 394
131844 AI419294 Hs 324342 ESTs 394
101607 X60111 Hs 1244 CD9 andgen (p24) 394
121613 AA416879 Hs 193195 ESTs, Weakly similar to 2109260A B cell 393
115815 AW905328 Hs 180842 πbosomal protein L13 393
125684 AW589427 Hs 158849 Homo sapiens cD FU21663 fis, clone C 393
126783 AA083531 gb zn09d10 s1 Stratagene hNT neuron (937 393
129201 H18359 Hs 109390 ESTs 393
128954 AA346839 Hs 209100 DKFZP434C171 protein 392
122939 AA477141 gb zu37g06 s1 Soares ovary tumor NbHOT H 392
130348 AB032957 Hs 210850 KIAA1131 protein 392
125847 AW161885 Hs 249034 ESTs 391
120452 AL022328 Hs 104335 hypothetical protein IMAGE3510317 391
123143 AA487595 gb aa95e02 s1 Stratagene fetal red 93 391
105729 H46612 Hs 293815 Homo sapiens HSPC285 mR, partial eds 391
106605 AW772298 Hs 21103 Homo sapiens R, cD DKFZp564B076 (fr 390
126714 AF114491 Hs 137354 egf like module containing, mucin like, 390
121611 M31669 Hs 1735 inhib , beta B (activin AB beta polypep 390
120468 AW967675 Hs 96487 ESTs, Highly similar to S08228 πbosomal 390
101356 AW878229 Hs 80642 sigl transducer and activator of trans 389
133668 L77964 Hs 271980 mitogen-activated protein kise 6 389
109114 BE622787 Hs 84045 hypothetical protein FLJ20288 388
115134 AW968073 Hs 194331 ESTs, Highly similar to A55713 inositol 388
107850 AA022910 Hs 295446 ESTs Moderately similar to 810024C cyto 388
130907 AA322866 Hs 21107 neuroligin 388
101879 AA176374 Hs 243886 nuclear autoantigenic sperm protein (his 388
104267 AF043244 Hs 278439 πucleolar protein 3 (apoptosis repressor 388
112232 BE253927 Hs 24983 hypothetical protein from EUROIMAGE 2021 388
113248 T63857 gb yc16e01 s1 Stratagene lung (937210) H 388
114044 BE327427 Hs 79953 ESTs 388
115414 AA662240 Hs 283099 AF15q14 protein 388
129598 N30436 Hs 11556 Homo sapiens cD FLJ12566 fis, clone NT 388
102134 AL036967 Hs 2324 protamme 2 387
106310 R98185 Hs 17240 ESTs 387
116470 AI272141 Hs 83484 SRY (sex determining region Y) box 4 386
110947 AW298410 Hs 21475 ESTs 385
115839 BE300266 Hs 28935 transducin-like enhancer of split 1, horn 385
103534 AW970672 Hs 9247 protein kise, AMP-activated, alpha 1 c 385
105209 AB023197 Hs 227743 KIAA0980 protein 385
108749 AA127017 Hs 71052 ESTs 385
110565 AI884970 Hs 4983 ESTs 385
110799 A1089660 Hs 323401 dpy-30 like protein 385
117068 H91257 Hs 41391 EST 385
130956 NMJ-01135 Hs 2159 aggrecan 1 (chondroidn sulfate proteogl 385
102273 BE391815 Hs 75981 ubiquitin specific protease 14 (tR gua 385
112960 AL110209 Hs 6770 LCAT-like lysophospholipase 384
114414 AW152166 Hs 182113 ESTs 384
109665 AA249439 Hs 27027 hypothetical protein DKFZp762H1311 384
106208 AK001674 Hs 22630 cofactor required for Sp1 transcπpdo 384
122311 NM 014913 Hs 131915 KIAA0863 protein 384
124271 AW293223 Hs 8928 hypothetical protein FLJ20291 383
106650 AL049951 Hs 22370 Homo sapiens mR, cD DKFZp564O0122 (f 383
112167 N99591 Hs 25587 ESTs, Weakly similar to T00329 hypothed 383
122354 AL157579 Hs 153610 KIAA0751 gene product 383
111462 R05296 gb ye91 e08 s1 Soares fetal liver spleen 381
128109 AW269421 Hs 128093 ESTs 381
127003 AW816515 Hs 173540 ATPase, Class V, type 10D 381
109210 AA669722 Hs 272137 ESTs 381
132543 BE568452 Hs 5101 protein regulator of cytokinesis 1 380
106827 AA457456 Hs 11408 hypothedcal protein FLJ20435 380
124232 H63391 Hs 339677 ESTs, Weakly similar to 138022 hypotheti 380
126039 AL137523 Hs 181102 p30 DBC protein 380
128022 AW195569 Hs 125906 ESTs 380 132005 AA149707 Hs 173091 ubiquitin like 3 3 79
131392 AA235153 Hs 26320 TRABID protein 379
131775 AB014548 Hs 31921 KIAA0648 protein 379
126257 N99638 gb za39g11 r1 Soares fetal liver spleen 379
121950 AA429515 gb zw75c05 s1 Soares testis NHT Homo sap 379
116067 AA454827 Hs 293637 ESTs 3 78
104658 AA360954 Hs 27268 Homo sapiens cD FU21933 fis, clone H 378
104493 AW960427 Hs 79059 transforming growth factor, beta recepto 377
100163 W44671 Hs 124 gene predicted from cD with a complete 377
116223 AF045458 Hs 47061 unc-51 (C elegans)-lιke kise 1 377
120586 AL031778 Hs 797 nuclear transcπption factor Y, alpha 376
128764 AW024282 Hs 104938 hypothetical protein MGC15906 375
111574 AI024145 Hs 188526 ESTs 375
117396 W20128 Hs 296039 ESTs 375
119052 R10889 gb yf38d02 s1 Soares fetal liver spleen 375
121806 AA424313 Hs 98402 ESTs 375
122410 AA446854 Hs 271004 ESTs, Weakly similar to I38022 hypothed 375
126638 AA649257 Hs 188602 ESTs 375
127879 AA768098 Hs 189079 ESTs 375
121095 AA320134 Hs 196029 Homo sapiens mR for KIAA1657 protein, 375
103430 BE564090 Hs 20716 translocase of inner mitochondπal membr 374
101230 AW504300 Hs 295605 mannosidase, alpha, class 2A, member 2 374
100200 H94688 Hs 173737 ras-related C3 botulmum toxin substrate 373
106913 AI219346 Hs 86178 M phase phosphoprotein 9 373
110975 H17012 Hs 14633 ESTs 373
117314 N32498 Hs 42829 ESTs 373
118737 AA199686 gb zq75g09 r1 Stratagene hNT neuron (937 373
124169 BE079334 Hs 271630 ESTs 373
124580 N68420 Hs 107992 ESTs 373
125747 NM 002884 Hs 865 RAP1 A, member of RAS oncogene family 373
124879 R73588 Hs 101533 ESTs 372
128527 AA504583 Hs 101047 transcπpdon factor 3 (E2A immunoglobul 372
103644 M13305 Hs 247787 opsin 1 (cone pigments), long wave-sensi 372
106044 N90344 Hs 149436 kmesin family member 5B 371
127867 C18530 gb C18530 Human placenta cD (TFujiwara 371
133828 T28472 Hs 7655 U2 small nuclear πbonucleoprotein auxil 3 71
107387 D86983 Hs 118893 Melanoma associated gene 371
104160 AA455706 Hs 44581 heat shock protein hsp70-related protein 371
106098 BE278344 Hs 970 DKFZP434B027 protein 370
133691 M85289 Hs 211573 heparan sulfate proteoglycan 2 (periecan 370
120717 AA904681 Hs 154434 ESTs, Weakly similar to unknown [H sapie 370
119263 T15977 gb IB2328 Infant brain, Bento Soares Horn 370
102305 AL043202 Hs 90073 chromosome segregation 1 (yeast homolog) 370
106566 BE298210 gb 601118016F1 NIH_MGC_17 Homo sapiens c 370
110708 N33878 Hs 306117 KIAA0306 protein 370
114357 R41677 Hs 6107 Homo sapiens cD FLJ14839 fis, clone OV 370
115285 AW972872 Hs 293736 ESTs 370
123034 AL359571 Hs 44054 ninem (GSK3B interacting protein) 370
126396 T06298 Hs 153326 EST 370
132597 Y11192 Hs 5299 aldehyde dehydrogese 5 family, member 370
105823 AI559444 Hs 293960 ESTs 370
102644 T59816 Hs 173311 C18B11 homolog (449kD) 370
133513 AF136407 Hs 7446 chromosome 6 open reading frame 5 370
116450 AI654450 Hs 47274 Homo sapiens mR, cD DKFZp564B176 (fr 369
104596 AF067804 Hs 15423 hypothedcal protein HDCMC04P 3 69
133579 X75346 Hs 75074 mitogen-activated protein kise xdvat 368
124556 N29317 Hs 236463 Homo sapiens mR, cD DKFZp586l0521 (f 368
120534 AI635113 Hs 270366 ESTs, Weakly similar to 178885 senne/th 368
103156 BE259039 Hs 129953 Ewing sarcoma breakpoint region 1 368
134992 AA464444 Hs 5831 dssue inhibitor of metalloproteise 1 368
106730 BE467313 Hs 260707 ESTs 368
120880 AA360240 Hs 97019 EST 368
123731 AA609839 gb ae62f01 s1 Stratagene lung carcinoma 368
126973 W46653 Hs 251928 nuclear pore complex interacting protein 367
103646 AW248439 Hs 2340 junction plakoglob 367
116333 AF155827 Hs 203963 hypothetical protein FLJ10339 367
120922 AA481003 Hs 97128 ESTs 367
127407 AW089514 Hs 279681 heterogeneous nuclear πbonucleoprotein 367
106578 AA836381 Hs 315111 nuclear receptor co-repressor/HDAC3 comp 367
123000 AI584156 Hs 105640 Homo sapiens, clone IMAGE 4139775, mR, 367
101464 AA852431 Hs 51299 DH dehydrogese (ubiqumone) flavopro 367
101397 M26380 Hs 180878 lipoprotein lipase 367
131135 NM 016569 Hs 267182 TBX3 iso protein 366
106112 AL117518 Hs 3686 KIAA0978 protein 366
123974 NM 015678 Hs 3821 neurobeachin 366
127742 AW293496 Hs 180138 ESTs 366
112908 BE281000 Hs 3530 TLS-associated seπne-arginine protein 2 366
131802 AL137406 Hs 296356 Homo sapiens mR, cD DKFZp434M162 (fr 365
135162 AI187925 Hs 95667 F-box protein 30 365
124984 BE313210 Hs 223241 eukaryotic transladon elongation factor 365
118844 AL035364 Hs 50891 hypothetical protein 365
125429 AI023654 Hs 114191 ESTs 365
125596 R25698 gb yg44h11 r2 Soares infant brain 1 NIB H 365 125792 AA496205 Hs 193700 Homo sapiens mR, cD DKFZp586l0324 (f 365
126965 A1470523 Hs 139336 ATP-bindmg cassette, sub-family C (CFTR 365
130776 AF167706 Hs 19280 cysteme-πch motor neuron 1 365
131949 AK000010 Hs 258798 hypothedcal protein FLJ20003 365
116612 C14904 Hs 45184 Homo sapiens cD FU12284 fis, clone MA 365
123749 AA609949 Hs 112790 EST 365
134203 AA161219 Hs 799 diphtheπa toxin receptor (hepann bmdi 364
133605 AL038165 Hs 75187 translocase of outer mitochondnal membr 364
109235 AI381800 Hs 300684 calcitoπm gene-related pepdde-receptor 364
125447 AI582222 Hs 128686 ESTs 363
122942 AI277829 Hs 111862 KIAA0590 gene product 363
122748 AA458822 Hs 193815 ESTs 363
103840 AW975861 Hs 47367 KIAA1785 protein 363
105333 AA234831 Hs 246112 KIAA0788 protein 363
108807 AI652236 Hs 49376 hypothetical protein FLJ20644 363
114699 AA127386 gb zπ90d09 r1 Stratagene lung carcinoma 363
126040 Z28444 Hs 24119 Homo sapiens mR, cD DKFZp586G2222 (f 363
131028 A1879165 Hs 2227 CCAAT/enhancer binding protein (C/EBP), 363
131710 NM 015368 Hs 30985 panπexm 1 363
100164 AW372032 Hs 173714 MORF-related gene X 362
120837 BE149656 Hs 306621 Homo sapiens cD FLJ11963 fis, clone HE 362
131089 Z42645 Hs 22870 Homo sapiens mR full length insert cDN 362
126428 AA412436 Hs 301985 ESTs 362
129148 AW501216 Hs 108945 KIAA0515 protein 361
102337 AI814663 Hs 170133 forkhead box 01A (rhabdomyosarcoma) 361
104520 AI702384 Hs 76925 hypothedcal protein FU14981 360
112954 AA928953 Hs 6655 Homo sapiens EST from clone 208499, full 360
125197 AF086270 Hs 278554 heterochromadn like protein 1 360
128124 AI125748 Hs 130194 ESTs 360
129553 AW015763 Hs 113065 ESTs 360
123998 AA203429 Hs 79474 tyrosine 3-monooxygese/tryptophan 5-mo 360
128835 AK001731 Hs 106390 Homo sapiens mR, cD DKFZp586H0924 (f 359
129226 BE222494 Hs 180919 inhibitor of D binding 2, dom t neg 359
135131 AI582743 Hs 94953 Homo sapiens, Similar to complement comp 359
128955 AA775076 Hs 185807 Homo sapiens, Similar to PRO0478 protein 358
100225 D28539 Hs 167185 glutamate receptor, metabotropic 5 358
101572 AA437199 Hs 656 cell division cycle 25C 358
102277 U31099 Hs 158326 prostaglandin D2 receptor (DP) 358
103667 Z80788 Hs 247815 H4 histone family, member L 358
112373 AW963357 Hs 7847 ESTs 358
119284 AL041224 Hs 65379 ESTs 358
125422 AA903229 Hs 153717 ESTs 358
126381 M76665 Hs 275215 hydroxysteroid (11-beta) dehydrogese 1 358
129168 AI132988 Hs 109052 chromosome 14 open reading frame 2 358
123133 AA487264 Hs 154974 Homo sapiens mR, cD DKFZp667N064 (fr 357
128789 AW368576 Hs 139851 caveolin 2 357
104172 AA476418 gb zx02a12 s1 Soares_total etus_Nb2HF8_ 357
134263 AW973443 Hs 8086 R (guanιne-7-) methyltransferase 357
101759 M80244 Hs 184601 solute earner family 7 (cadoπic ammo 357
104942 NM 016348 Hs 10235 chromosome 5 open reading frame 4 356
123443 BE244537 Hs 167382 tπuredc peptide receptor Aguanylate 356
110707 AI239832 Hs 15617 ESTs Weakly similar to ALU4 HUMAN ALU S 355
106787 AI492261 Hs 32450 ESTs 355
112940 AK001757 Hs 281348 hypothetical protein FLJ 10895 355
115301 T11832 Hs 127797 Homo sapiens cD FLJ11381 fis, clone HE 355
125978 N66843 Hs 35608 ESTs 355
128002 AI985897 Hs 125293 ESTs 355
119847 H81136 Hs 334604 Homo sapiens mR for KIAA1870 protein, 355
134595 NMJ02401 Hs 29282 mitogen-activated protein kise kise 355
121309 AA293834 Hs 97312 ESTs 354
122679 AA811286 Hs 192837 ESTs, Weakly similar to ALU5 HUMAN ALU S 354
106061 AA565356 Hs 13250 ESTs 354
127207 AA377165 Hs 44833 ESTs 354
129563 AF119664 Hs 27299 transcπpdol regulator protein 354
105951 R48700 Hs 20733 Homo sapiens cD FLJ22356 fis clone H 353
115643 AA404276 Hs 123253 hypothetical protein FLJ22009 353
130473 U11690 Hs 1572 faciogenital dysplasia (Aarskog Scott sy 353
104246 AF016032 Hs 201377 lysosomal 353
120562 BE244580 Hs 302267 hypothedcal protein FLJ10330 353
101211 AA355357 Hs 283429 SMC (mouse) homolog, X chromosome 353
100774 J05581 Hs 89603 mucin 1, transmembrane 353
108407 AA075519 gb zm87h09 s1 Stratagene ovaπan cancer 353
113538 A1554947 Hs 15167 ESTs, Weakly similar to S37482 finger pr 353
113876 AI799751 Hs 5635 ESTs 353
110731 NM 014899 Hs 188006 KIAA0878 protein 352
125845 AK00144O Hs 131840 hypothetical protein FLJ 10578 351
112945 AW138458 Hs 20787 Homo sapiens cD FLJ21686 fis, clone C 351
131686 NM 012296 Hs 30687 GRB2-assocιated binding protein 2 351
125413 AI887951 Hs 74566 dihydropynmidise like 3 351
129360 AJ000534 Hs 110708 sarcoglycan, epsilon 350
128819 R380O7 Hs 77578 ubiquitin specific protease 9, X chromos 350
101973 U41514 Hs 80120 UDP-N acetyl alpha-D-galactosamine polyp 350
103616 NM 002647 Hs 32971 phosphomosιtιde-3-kιse, class 3 350 105535 AI459519 Hs 297681 senne (or cysteine) proteise mhibito 350
118767 AI038653 Hs 50500 ESTs 350
126634 AW361109 Hs 43627 SRY (sex determining region Y) box 22 350
130851 R66282 Hs 20247 ESTs, Weakly similar to S65657 alpha-1 C- 350
134353 AL138201 Hs 82120 nuclear receptor subfamily 4, group A, m 350
111394 AA412227 Hs 16131 hypothetical protein FLJ12876 350
102696 BE540274 Hs 239 forkhead box M1 349
113037 R17268 Hs 259873 axol transport of sypdc vesicles 349
111028 H59346 Hs 30151 ESTs, Weakly similar to I38022 hypothed 349
131688 AI935413 Hs 30692 p21 (CDKNIA)-acdvated kise 2 349
115613 AW136951 Hs 173946 hypothetical protein FLJ10486 348
116975 H81076 Hs 269001 ESTs 348
100210 D26361 Hs 3104 KIAA0042 gene product 348
110147 H18700 Hs 268799 ESTs 348
115600 AA081395 Hs 42173 Homo sapiens cD FLJ1036Sfis, clone NT 348
119088 R39261 Hs 90790 Homo sapiens cD FLJ22930 fis, clone K 348
120347 AA211068 Hs 120247 nuclear fragile X mental retardation pro 348
122702 AI220089 Hs 99439 ESTs 348
125552 H09701 Hs 278366 ESTs, Weakly similar to I38022 hypotheti 348
126461 AI381659 Hs 267086 ESTs 348
128572 AA933022 Hε 256583 interieukin enhancer binding factor 3, 9 348
118397 BE139479 Hs 161492 ESTs 347
127999 AW978827 Hs 69851 nucleolar protein family A, member 1 (H/ 347
132066 AI929392 Hs 181195 DJ (Hsp40) homolog, subfamily B, membe 347
105693 BE250951 Hs 181368 U5 snRNP-specific protein (220 kD), orth 347
128874 H06245 Hs 106801 ESTs, Weakly similar to PC4259 ferπdπ 346
119984 AA230228 Hs 59197 ESTs 346
104000 AI146527 Hs 80475 polymerase (R) II (D directed) polyp 346
101488 BE547216 Hs 181128 ELK1, member of ETS oncogene family 346
101045 J05614 gb Human proliferating cell nuclear and 346
120149 AA227609 Hs 94834 ESTs 346
107025 AA825523 Hs 21255 ESTs, Weakly similar to I38022 hypotheti 345
101716 AF050658 Hs 2563 lachykinin, precursor 1 (substance K, su 345
102899 AI815559 Hs 75730 sigl recognidon particle receptor (d 345
123075 AW293133 Hs 101340 ESTs, Weakly similar to A42442 integrin 345
124695 AA594979 Hs 239307 tyrosyl-tR synthetase 345
127669 N28989 Hs 22891 solute earner family 7 (cationic ammo 345
129793 AW207000 Hs 126857 Homo sapiens cD FLJ 12936 fis, clone NT 344
120095 AA693774 Hs 59601 ESTs 344
110915 BE092285 Hs 29724 hypothetical protein FU13187 343
130542 U64675 Hs 179825 RAN binding protein 2-lιke 1 343
100488 BE273749 Hs 752 FK506-bιndιng protein 1 A (12kD) 343
115027 AA743331 Hs 272572 hemoglobin, alpha 2 343
119298 NM 001241 Hs 155478 cyclm T2 343
126486 AI065133 Hs 152316 hypothetical protein PRO0971 343
130021 M24470 Hs 1435 guanosine onophosphate reductase 343
127166 AW954605 Hs 263395 sema domain, transmembrane domain (TM), 342
114988 AA251089 gbzs04f05s1 NCI_CGAP_GCB1 Homo sapiens 342
133817 AW578716 Hs 7644 H1 histone family, member 2 341
133562 M60721 Hs 74870 H20 (Drosophιla)-lιke homeo box 1 341
105610 AA280072 Hs 99872 fetal Alzheimer antigen 341
129007 AK001521 Hs 107882 hypothetical protein FU10659 341
100662 AI368680 Hs 816 SRY (sex determining region Y)-box 2 341
120159 R60781 Hs 92927 putative 47 kDa protein 341
134966 AW402389 Hs 920 modulator recognition factor I 341
100369 D79988 Hs 115778 KIAA0166 gene product 341
104260 AF008192 Hs 194283 putative GR6 protein 340
100134 AA305746 Hs 49 macrophage scavenger receptor 1 340
116015 AA338648 Hs 50334 testes development-related NYD-SP22 340
119251 T15753 Hs 65250 EST 340
127176 BE387162 Hs 280858 ESTs, Highly similar to A35661 D excis 340
123422 AA598484 gb ae38f04 s1 Gessler Wil s tumor Homo s 339
123094 AA761073 Hs 146847 TRAF family member-associated NFKB acdv 339
105289 AB020638 Hs 103000 KIAA0831 protein 339
111219 N68836 Hs 19247 ESTs, Moderately similar to ALUCHUMAN ' 338
127963 AI299013 Hs 87779 Homo sapiens cD FLJ 23087 fis, clone L 338
109412 BE543313 Hs 209473 hypothetical protein FU 10520 338
118794 AW517051 Hs 118210 ESTs 338
112040 R43286 gb yg17e11 s1 Soares infant brain 1NIB H 338
111180 AI798851 Hs 283108 hemoglobin, gamma G 338
117329 AA524065 Hs 93670 Homo sapiens cD FLJ22664 fis, clone H 338
104371 AI288696 Hs 194081 ESTs, Weakly similar to I38022 hypothed 338
109265 AA195285 Hs 85982 ESTs 338
109557 AW452405 Hs 6427 ESTs 338
120753 AA312551 Hs 230157 ESTs 338
120970 AA398118 Hs 97579 ESTs, Weakly similar to A46010 X-linked 338
127094 F13215 Hs 287849 ESTs, Weakly similar to T22074 hypothed 338
127746 AI239495 Hs 120189 ESTs 338
123553 AI494291 Hs 111977 ESTs 337
130652 M31669 Hs 1735 inhibm, beta B (acdvm AB beta polypep 337
135101 U82275 Hs 94498 leukocyte immunoglobulin-like receptor, 337
121799 AI885670 Hs 124027 SELENOPHOSPHATE SYNTHETASE , Human selen 337
112278 Z41698 Hs 26039 Homo sapiens cD FU 13937 fis, clone Y7 336 113401 AA610175 Hs 179647 Homo sapiens cD FU12195 fis, clone MA 336
109292 AW975746 Hs 188662 KIAA1702 protein 336
135026 N92165 Hs 93231 ESTs 336
118210 N49233 Hs 46914 ESTs, Weakly similar to A46010 X-lmked 335
123476 AA384564 Hs 108829 ESTs 335
111076 N59129 Hs 20851 ESTs 335
111520 AI985369 Hs 301134 ESTs 335
133383 BE313555 Hs 7252 KIAA1224 protein 335
103731 AA070545 gb zm70c03 r1 Stratagene neuroepithelium 335
110828 AK002114 Hs 23495 hypothedcal protein FLJ 11252 335
112520 R68654 Hs 30814 ESTs 335
115725 AW899053 Hs 76917 F-box only protein 8 335
125867 H13331 Hs 123721 ESTs 335
127719 AI242163 Hs 22670 chromodomain helicase D binding prolei 335
129863 BE379765 Hs 129872 sperm associated andgen 9 335
130816 M61877 Hs 1985 spectπn, alpha erythrocytic 1 (ellipto 335
130888 AL044315 Hs 173094 Homo sapiens R for KIAA1750 protein, 335
133377 AJ131245 Hs 7239 SEC24 (S cerevisiae) related gene famil 335
118986 AF148713 Hs 125830 bladder cancer overexpressed protein 335
101723 U34304 gb Human πonmuscle myosin heavy chain II 334
134693 N70361 Hs 8854 Human transcπption unit PVT gene, exons 334
102856 M26150 Hs 248177 H3 histone family, member L 334
105593 AA279341 Hs 174151 aldehyde oxidase 1 334
134748 L34059 Hs 89484 cadheπn 4, type 1, R-cadheπn (redl) 334
109149 AA831179 Hs 40065 hypothedcal protein MGC4825 333
115026 AA251972 Hs 188718 ESTs 333
103546 Z14244 Hs 75752 cytochrome c oxidase subunit Vllb 333
111189 N67603 Hs 272130 ESTs, Weakly similar to S65824 reverse t 333
127076 AI422951 Hs 146162 ESTs 333
124949 AI903210 Hs 336780 tubulin, beta polypeptide 333
111012 AI077389 Hs 269818 ESTs, Weakly similar to Z195_HUMAN ZINC 333
113412 AW628660 Hs 44131 KIAA0974 protein 333
116351 AL133623 Hs 82501 similar to mouse Xrn1 / Dhm2 protein 333
121633 AA417011 Hs 98175 EST 333
124591 N69243 Hs 192974 hypothetical protein FLJ12735 333
130225 AB021179 Hs 15299 HMBA-inducible 333
131945 NM 002916 Hs 35120 replication factor C (activator 1) 4 (37 3 33
132581 AK000631 Hs 52256 hypothetical protein FLJ20624 333
105726 NM 012068 Hs 9754 activating traπscπption factor 5 332
101867 M96132 gb Human MHC class II HLA-DR-beta 1*0901 332
105004 BE616023 Hs 25298 KIAA1813 protein 332
100288 AL039103 Hs 153834 pumilio (Drosophila) homolog 1 332
118349 N63786 Hs 94149 ESTs, Weakly similar to ALU1.HUMAN ALU S 3 32
103352 H09366 Hs 78853 uracil D glycosylase 330
107436 W27720 Hs 12450 protocadheππ 9 330
109062 AA160941 gb zq40d12 s1 Stratagene hNT neuron (937 330
110379 AI300505 Hs 33130 Homo sapiens cD FLJ23486 fis, clone L 330
111221 AB037782 Hs 15119 KIAA1361 protein 330
117903 AA768283 Hs 47111 ESTs 330
123265 AA491209 gb aa47a08s1 NCI_CGAP_GCB1 Homo sapiens 330
128226 A1284940 Hs 289082 GM2 ganglioside activator protein 330
111945 R40663 Hs 124944 ESTs 330
126214 AW748336 Hs 168052 KIAA0421 protein 3 30
121073 H46199 Hs 112184 DKFZP586J0619 protein 330
102083 T35901 Hs 75117 interieukin enhancer binding factor 2 4 330
100992 NM_007289 Hs 1298 membrane metallo-endopepddase (neutral 330
134021 L13720 Hs 78501 growth arrest specific 6 330
126452 R26867 gb yh52e01 s1 Soares placenta Nb2HP Homo 329
117195 AI798425 Hs 42710 ESTs 329
127663 AK000452 Hs 10340 hypothedcal protein FU20445 3 29
113677 Z70200 Hs 246112 KIAA0788 protein 328
132398 AA876616 Hs 16979 ESTs, Weakly similar to A43932 mucin 2 p 328
109533 AL043979 Hs 259729 KIAA0596 protein 328
102915 X07820 Hs 2258 matπx metalloproteise 10 (stromelys 328
104348 H05405 Hs 19221 hypothetical protein DKFZp566G1424 328
113047 AI571940 Hs 7549 ESTs 328
113203 AA743563 Hs 10305 ESTs 328
114503 AL040600 Hs 188083 ESTs 328
122100 AA431220 Hs 41086 pleckstπn homology domain-containing, f 328
123073 AA485061 Hs 105652 ESTs 328
130253 AI078570 Hs 167473 phosphoglucomutase 5 328
130365 W56119 Hs 155103 eukaryotic translation initiation factor 328
130762 D84371 Hs 1898 paraoxose 1 328
132360 AW893660 Hs 46440 solute earner family 21 (organic anion 328
110763 AI928445 Hs 92254 syptotagmin like 2 327
103437 AV655598 Hs 184211 pepddase (mitochondnal processing) bet 327
114840 AA447591 Hs 87359 ESTs, Highly similar to RB18_HUMAN RAS R 327
106888 AA020964 Hs 24734 oxysterol binding protein 327
129896 BE295568 Hs 13225 UDP-Gal betaGlcc beta 1,4- galactosylt 326
113459 T80206 Hs 14716 ESTs 326
134332 D86962 Hs 81875 growth factor receptor-bound protein 10 326
117048 H89732 Hs 230113 EST 326
109249 AA194730 Hs 268189 hypothetical protein FLJ20436 326 134663 W73428 Hs 8750 uncharacteπzed bone marrow protein BM04 326
114440 AL046511 Hs 106525 hypothetical protein FU12567 325
102196 BE266830 Hs 75238 chromatin assembly factor 1, subunit B ( 325
109581 R45584 Hs 23025 ESTs, Weakly similar to ALU5_HUMAN ALU S 325
120814 AW867796 Hs 96860 ESTs, Weakly similar to I38022 hypothed 325
122391 AA446316 Hs 191622 ESTs 325
122553 AA451884 Hs 190121 ESTs 325
124755 R38087 Hs 267690 KIAA1228 protein 325
130943 U20760 Hs 272429 calcium sensing receptor (hypocalciuπc 325
115185 BE299677 Hs 105461 hypothetical protein FLJ20357 325
114297 AA149707 Hs 173091 ubiquidn-like 3 325
106657 AW854339 Hs 33476 hypothedcal protein FLJ11937 325
124320 H95749 Hs 102342 EST 325
124087 H08773 Hs 288590 Homo sapiens cD FU11454 fis, clone HE 324
110705 AB007902 Hs 32168 KIAA0442 protein 324
106508 AI205785 Hs 30348 ESTs 324
112538 AA908813 gb og77h06 s1 NCI_CGAP_Ov8 Homo sapiens 324
100130 NM 000304 Hs 103724 peπpheral yelin protein 22 324
106017 AA477956 Hs 26268 ESTs 324
113921 AW976530 Hs 28355 hypothedcal protein FLJ22402 323
121520 AA412163 Hs 164785 ESTs 323
129255 AI961727 Hs 109804 H1 histone family, member X 323
125069 H81306 Hs 194485 ESTs 323
119863 AA081218 Hs 58608 Homo sapiens cD FLJ14206 fis, clone NT 323
111273 N70934 gb za33f06 s1 Soares fetal liver spleen 323
102971 X16609 Hs 183805 aπkyπn 1, erythrocytic 323
103937 AA934063 Hs 13836 ESTs, Weakly similar to I38022 hypotheti 323
121770 NM 015902 Hs 278428 progestin induced protein 323
128972 AA528140 Hs 107515 ESTs, Weakly similar to T00329 hypotheti 323
132528 T78736 Hs 50758 SMC4 (structural mamtence of chromoso 323
134835 L04569 Hs 89925 calcium channel, voltage-dependent L ty 323
103158 BE242587 Hs 118651 hematopoietically expressed homeobox 322
118405 AL117518 Hs 3686 KIAA0978 protein 322
104631 AA002064 Hs 18920 ESTs 322
114253 BE149866 Hs 14831 Homo sapiens, Similar to zinc finger pro 322
134607 AI675881 Hs 86538 ESTs 322
135114 AW340493 Hs 175043 ancient conserved domain protein 4 322
120191 BE407106 Hs 65907 Homo sapiens, clone IMAGE 3959816, mR, 322
105029 AI122691 Hs 13268 ESTs 321
128550 AA418276 Hs 170142 ESTs 321
119873 AI660149 Hs 44865 lysosomal 321
130115 T47294 Hs 149923 X-box binding protein 1 321
133916 AL039185 Hs 77558 thyroid hormone receptor interactor 7 321
120259 AW014786 Hs 192742 hypothetical protein FU 12785 321
110721 H97678 Hs 31319 ESTs 321
130062 AL049415 Hs 278679 a dismtegπn and metalloproteise doma 321
100265 D38521 Hs 112396 KIAA0077 protein 320
100624 AB001025 Hs 9349 ryanodme receptor 3 320
122275 AA437124 Hs 187247 ESTs 320
127099 AA347668 gb EST54026 Fetal heart II Homo sapiens 320
134321 BE538082 Hs 8172 ESTs, Moderately similar to A46010 X Im 320
132809 AF036144 Hs 5734 meningioma expressed antigen 5 (hyaluron 320
101125 AJ250562 Hs 82749 transmembrane 4 superfamily member 2 320
128339 AL121087 Hs 296406 KIAA0685 gene product 319
117121 H95044 Hs 321386 EST 3 19
124760 AW408586 Hs 91052 ESTs, Moderately similar to ALU5 HUMAN A 3 19
132232 AI522273 Hs 42640 ESTs 3 19
125919 W26713 Hs 256972 ESTs 3 19
123324 AB018352 Hs 105399 KIAA0809 protein 319
100157 D14661 Hs 119 Wilms' tumour 1-assocιatιng protein 3 19
101447 M21305 gb Human alpha satellite and satellite 3 3 19
124345 NM 014487 Hs 120766 nucleolar cysteine rich protein 318
122583 NM 012447 Hs 20132 stromal antigen 3 318
128961 AL133014 Hs 107387 CGI-20 protein 3 18
111321 AI569766 Hs 13205 ESTs 3 18
134977 AL044963 Hs 306121 leukocyte receptor cluster (LRC) encoded 3 18
131535 N22120 Hs 75277 hypothetical protein FU13910 318
109950 H08200 Hs 268770 ESTs, Weakly similar to 2004399A chromos 3 18
129875 AA181018 Hs 13056 hypothedcal protein FU13920 318
101654 M60298 Hs 733 erythrocyte membrane protein band 42 318
104732 AL079294 Hs 29952 Homo sapiens mR full length insert cDN 3 18
106867 AB037744 Hs 34892 KIAA1323 protein 3 18
108301 AA069728 Hs 184582 πbosomal protein L24 318
118042 AI432389 Hs 161465 ESTs 318
120900 AA830712 Hs 291931 ESTs 318
129312 T97579 Hs 110334 ESTs, Weakly similar to I78885 seπne/th 318
116291 AW410377 Hs 41502 hypothedcal protein FU21276 317
110672 AW612890 Hs 191178 ESTs 3 17
115665 BE072425 Hs 44579 hypothedcal protein FU20199 317
127581 AK000680 Hs 266175 phosphoprotein associated with GEMs 3 17
129584 AV656017 Hs 184325 CGI 76 protein 3 16
108830 AA131743 Hs 193352 ESTs 3 16
124443 AI857519 Hs 302031 zinc finger protein, subfamily 1 A 4 (Eo 316 106290 AW961393 Hs 16364 hypothedcal protein FU 10955 316
122787 AI209093 Hs 99512 ESTs 316
133112 T15465 Hs 182231 Ihyrotropin-releasing hormone 3 16
116435 AA186761 Hs 334812 hypothetical protein DKFZp586K0717 3 16
109121 BE389387 Hs 49767 DH dehydrogese (ubiqu one) Fe-S pro 3 16
126721 AW579621 Hs 125359 Thy-1 cell surface andgen 315
102526 AA203429 Hs 79474 tyrosine 3-monooxygese/tryptophan 5-mo 3 15
100512 D13317 Hs 78915 GA-bindmg protein transcπpdoπ factor, 315
105299 AF098951 Hs 194720 ATP-biπding cassette, sub-family G (WHIT 315
117842 AI984505 Hs 161121 ESTs 315
123049 BE047680 Hs 211869 dickkopf (Xenopus laevis) homolog 2 315
128639 AW582962 Hs 102897 CGI-47 protein 315
130343 AB040914 Hs 278628 KIAA1481 protein 315
115706 AB004849 Hs 50748 chromosome 21 open reading frame 18 315
120673 AW968634 Hs 105093 ESTs 3 15
132116 AW960474 Hs 40289 ESTs 3 15
116217 AU076474 Hs 123178 translocase of inner mitochondπal membr 315
104926 BE298808 Hs 33363 DKFZP434N093 protein 314
105297 NM 015905 Hs 183858 transcnpdol intermediary factor 1 314
125343 A1475495 Hs 304101 ESTs, Weakly similar to ALU7_HUMAN ALU S 314
115618 H11695 Hs 322901 disrupter of silencing 10 314
124893 AA830185 Hs 269680 ESTs 313
105461 BE539071 Hs 69388 hypothetical protein FU20505 313
126165 AI741816 Hs 125897 ESTs 313
105212 AA205334 Hs 324278 Homo sapiens mR, cD DKFZp566M063 (fr 313
101628 M57506 Hs 72918 small inducible cytokine A1 (I-309, homo 313
107951 AI300077 Hs 61590 ESTs 313
109166 AA219691 Hs 73625 RAB6 interacting, kmesin-like (rabkines 313
117299 N75768 gb yw30b07 r1 Morton Fetal Cochlea Homo 313
119694 AA041350 Hs 57847 ESTs, Moderately similar to ICE4_HUMAN C 3 13
124840 R56146 Hs 164515 EST, Weakly similar to AF090930 1 PRO047 313
127433 AW979155 Hs 298275 am o acid transporter 2 313
128337 AI123529 Hs 166592 ESTs 313
134053 AW628686 Hs 78851 KIAA0217 protein 3 13
134475 NM 014733 Hs 83790 KIAA0305 gene product 3 13
128761 BE300341 Hs 104925 ectodermal neural cortex (with BTB like 312
124971 T23800 Hs 151001 hypothetical protein FLJ14728 312
128314 T87479 Hs 291797 ESTs 312
134695 AB036829 Hs 178347 SKIP for skeletal muscle and kidney enπ 312
131333 BE244603 Hs 25726 transposon-deπved Busted transposase-l 312
119781 AJ278016 Hs 55565 ankyπn repeat domain 3 312
131824 U28838 Hs 32935 TATA box binding protein (TBP)-assocιate 311
124595 AW194851 Hs 111801 arsete resistance protein ARS2 311
116115 AL042355 Hs 70202 WD repeat domain 10 311
129415 AI907084 Hs 111243 MADS box traπscnpdon enhancer factor 2 311
111552 T97939 Hs 191185 ESTs 310
134861 NM-000937 Hs 171880 polymerase (R) II (D directed) polyp 310
104971 BE311926 Hs 15830 hypothetical protein FLJ12691 310
126536 AA156151 gb zo48c06 r1 Stratagene endothelial cel 310
128246 AI990612 Hs 214818 DMRT like family C2 310
106412 AA453734 Hs 10198 ESTs 310
107902 AA026627 Hs 61358 ESTs 310
112495 AI346487 Hs 28739 ESTs 309
131870 NM 014874 Hs 3363 KIAA0214 gene product 309
105301 AW352357 Hs 7457 MAGE1 protein 309
123670 AI189844 Hs 112708 ESTs, Moderately similar to ZN91.HUMAN Z 309
116474 AW160774 Hs 159154 tubulin, beta, 4 309
112064 AL049390 Hs 22689 Homo sapiens mR, cD DKFZp58601318 (f 309
130525 AA361850 Hs 322149 Human clone 137308 R, partial eds 308
120398 AL133649 Hs 110953 retinoic acid induced 1 308
102735 AF111106 Hs 3382 protein phosphatase 4, regulatory subuni 308
124748 R34617 gb yh85h12 s1 Soares placenta Nb2HP Homo 308
120755 AA312934 Hs 190745 Homo sapiens cD FLJ21326 fis, clone C 308
118895 BE304917 Hs 31097 hypothetical protein FLJ21478 308
107463 AW952022 Hs 315164 hypothedcal protein similar to acdn re 308
114290 R51383 Hs 25793 ESTs 308
119005 AL038511 Hs 125316 ESTs, Weakly similar to S33990 finger pr 308
125676 BE612918 Hs 151973 hypothetical protein FU23511 308
127766 AA723659 Hs 290607 EST 308
132693 BE244200 Hs 55075 KIAA0410 gene product 307
106812 BE251590 Hs 239370 DKFZP727I051 protein 307
125654 X96753 Hs 9004 chondroitin sulfate proteoglycan 4 (mela 307
111836 R58394 Hs 25119 ESTs, Weakly similar to YEXO.YEAST HYPOT 306
101682 AF043045 Hs 81008 filamin B, beta (actin-bmding protem-2 306
110004 H10413 Hs 268774 ESTs 306
117591 N64777 Hs 44656 ESTs 306
110737 AA335609 Hs 7589 ESTs, Weakly similar to A46010 X-lmked 306
134337 NM_004922 Hs 81964 SEC24 (S cerevisiae) related gene famil 306
132450 AA100012 Hs 48827 hypothetical protein FLJ12085 306
125556 AB033064 Hs 334806 KIAA1238 protein 306
101811 NM_002556 Hs 24734 oxysterol binding protein 306
131530 AA574309 Hs 283402 TCR eta 306
105049 AB032945 Hs 172506 myosin VB 306 126614 AA701941 Hs 187555 ESTs 305
130960 AF035621 Hs 21611 kmesin family member 3C 305
105503 AW963624 Hs 31707 ESTs, Weakly similar to YEW4_YEAST HYPOT 305
107361 U72513 Hs 159486 Human RPL13-2 pseudogene mR complete 305
107575 D81886 Hs 59908 ESTs 305
116999 H84644 Hs 40707 EST 305
119554 W38188 (NONE) 305
120934 AA226198 gb nc26a07 s1 NCI_CGAP_Pr1 Homo sapiens 305
125805 AI160594 Hs 166656 ESTs, Highly similar to S49460 glutamate 305
127263 AA331156 gb EST35034 Embryo, 6 week subtracted ( 305
128025 T64877 Hs 108479 ESTs 305
131090 AI143139 Hs 2288 visimn like 1 305
112197 NM 003655 Hs 5637 ESTs 305
133492 L40397 Hs 74137 transmembrane trafficking protein 304
118485 AA508515 Hs 291049 ESTs 304
113893 AI373741 Hs 59384 hypothetical protein MGC3047 304
116911 AW205577 Hs 308435 ESTs, Moderately similar to KIAA0745 pro 304
132833 U78525 Hs 57783 eukaryotic translation initiation factor 304
124724 H20816 Hs 112423 Homo sapiens mR, cD DKFZp586l1420 (f 304
105894 AI904740 Hs 25691 receptor (calcitonin) acdvity modifying 304
129991 R28386 Hs 179925 ESTs, Weakly similar to ALU8_HUMAN ALU S 304
128714 T85231 Hs 179661 tubulin, beta 5 304
134650 U76376 Hs 87247 harakiπ, BCL2-ιnteraohng protein (cont 304
106851 AI458623 gb tk04g09 x1 NCI_CGAP_Lu24 Homo sapiens 304
133445 AC005262 Hs73797 guanine nucleodde binding protein (G pr 304
102581 AU077228 Hs 77256 enhancer of zeste (Drosophila) homolog 2 304
127542 AA703684 Hs 245474 ESTs, Moderately similar to ALU5.HUMAN A 303
113043 AI628789 Hs 7483 ESTs 303
134710 AI433797 Hs 8889 senne hydroxymethyltransferase 1 (solub 303
119245 AI815733 Hs 114360 transforming growth factor beta-sdmulat 303
106391 AW959538 Hs 321214 hypothetical protein DKFZp564D0478 303
114607 AF041260 Hs 129057 breast carcinoma amplified sequence 1 303
116083 AA455706 Hs 44581 heat shock protein hsp70 related protein 303
132079 AI701457 Hs 38694 ESTs 303
103825 AI571835 Hs 55468 ESTs 303
106438 AI141031 Hs 21342 ESTs 303
124359 N22508 Hs 139315 Homo sapiens cD FU21479 fis clone C 303
126384 AW090198 Hs4779 KIAA1150 protein 303
127995 AA970953 Hs 128709 ESTs 303
127981 AA837029 Hs 157463 ESTs 302
124417 N34059 gb yv28h09 s1 Soares fetal liver spleen 302
124357 N22401 gb yw37g07 s1 Morton Fetal Cochlea Homo 302
105437 AF151076 Hs 25199 hypothetical protein 302
101158 AW327723 Hs 76122 splicing factor, argin e/seπne-πch 4 302
113897 R91601 Hs4947 hypothetical protein FU22584 302
100159 AA285268 Hs 23488 KIAA0107 gene product 302
106487 AI697340 Hs 135265 Homo sapiens clone FLB8436 PR02277 mR 302
124977 F04819 Hs 190452 KIAA0365 gene product 302
131631 AA022569 Hs 29802 slit (Drosophila) homolog 2 301
102259 AL041219 Hs 82222 sema domain, immunoglobulin domain (lg), 301
104399 AL022316 Hs 301947 kraken like 301
116536 BE218027 Hs 89969 ESTs 300
125889 AA351978 Hs 4943 hepatocellular carcinoma associated prot 300
102233 AW163045 Hs 79334 nuclear factor interieukin 3 regulated 300
102628 U90322 Hs 27812 G protein-coupled receptor 23 300
112812 H55977 Hs 35810 ESTs 300
114654 AA101840 Hs 103679 ESTs 300
118555 N68372 gb za68c10 s1 Soaresjetal lung_NbHL19W 300
120005 W90105 Hs94942 EST 300
123596 AA421130 Hs 112640 EST 300
126134 AL133033 Hs4084 KIAA1025 protein 300
126194 H98755 Hs 302975 ESTs Weakly similar to Z195.HUMAN ZINC 300
129778 AK001676 Hs 12457 hypothetical protein FU10814 300
Table 3B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT number Accession
123619 371681.1 AA602964 AA609200
124417 1642364 1 N34059 N46979
117299 1632586J N75768 N22543
116845 393481.1 AA649530 AA659316 H64973
124748 1715080 -1 R34617
125596 1708455.1 R25698 R56582 R56018
126257 182217 1 N99638 AW973750 AA328271 H90994 AA558020 AA234435 N59599 R94815
126280 1572221 1 219417 H20866
126319 1528523.1 D81689 D81802
104172 273499.1 AA476418 AA393338 AA398747 AA476518
126426 110687.1 AA125984 AA127189 AA065075 AA070377 AA100017 AA079891 AA113255 AA075168 AA082764 AA083380 N84829 AA084752
AA076512 AA085119 AA085208 AA085045
126433 1271431 AA325606 AA099517 N89423 127092 1779998 1 T26985 Z44165
127099 244301 1 AA347668 AW956810 Z44271 F07065 F07064 R13506
126536 149206 1 AA156151 Z25109 C05177
103731 112052.1 AA070545 AA131490 AA131373
127263 232161 1 AA331156 AA331157 AA331155
126783 113388 1 AA083531 AA126047 AA074915 AA148649
118946 1683457 1 N92834 W25061
127520 656170 -1 T51239
127532 353907 1 AJ003429 AJ003367 AA564825
112516 1744223 1 T83909 R68586
112538 504579 1 AA908813 R70255
112540 1605263 1 R69751 R70467 H69771 H80879 H80878
113248 328626 1 T63857 AW971220 AA493469 T63699
112631 1746257 1 R82040 R70934
128360 1540098 1 F12374T74059
120514 25532 3 AA258335 AA258499
127867 1511945 1 C18530T63953
120637 200885 1 AA811804 AA8094O4 AA286907 AW977624
121481 123001 1 AA411931 AA411930
120934 177521 1 AA226198 AA226513 AA383773
106566 120358.1 BE298210 AI672315 AW086489 BE298417 AA455921 AA902537 BE327124 R14963 AA085210 AW274273 AI333584 AI369742
AI039658 AI885095 AI476470 AI287650 AI885299 AI985381 AW592624 AW340136 AI266556 AA456390 AI310815 AA484951
121743 274582.1 AA397636 AA421144
114699 135322 1 AA127386 R15644AA127404
106851 322947.1 AI458623 AA639708 AA485409 R22065 AA485570
123731 genbank AA609839 AA609839
123973 506369 -1 C14805
116793 74964.1 T77781 AW014157 D12422 AI918246 AA452599 AA628404 N35886 AA464593 AW301738 T77780 AI042309 AI095302 H60603
AW510576 H37814 W61360 AI373286 AI702287 AA152465 AW169067 AW169012 AW340355 AI289311
109700 genbank_F09609 F09609
118466 genbaπk_N66741 N66741
111273 genbank_N70934 N70934
118555 genbank_N68372 N68372
111462 genbank_R05296 R05296
118720 genbank N73515 N73515
118737 382979.1 AA199686 N73861
111826 genbank_R35975 R35975
120376 genbank_AA227469 AA227469
120809 genbank_AA346495 AA346495
120839 genbank_AA348913 AA348913
120873 genbank_AA358015 AA358015
115498 genbank_AA291070 AA291070
101045 entiBZ_J05614 J05614
129969 genbank_N57818 N57818
108407 genbank \A075519 AA075519
122939 genbank_AA477141 AA477141
117031 geπbank_H88353 H88353
124298 genbank H91679 H91679
117099 321871.1 H93699 H97976 H80036
101447 entrez_M21305 M21305
124357 genbank N22401 N22401
101723 2603 1 U34304AA355800 M69181 AA375523 AA093590 AA365595 S67247AI371761 AW351920AW181991 H28934 W79172AA653543
AA122005 W95572 AF086505 C02448 W57668 T11988 W95465 AA425179 F05724 F12205 F06285 R16384 T66222 F08515
F07288 AA150346 H83264 T86770 N36366 AA337253 H12001 H82899 H69395 H69380 N29054 N30920 T97385 T96819
AA463807 AL079860 T11987 AA305048 AA149133 T82813 AA029555 AA035109 AA449123 AA340297 AA724155 W05196
AI859528 AA149134 C16426 C16097 C16587 C16138 C16107 AW021754 C16500 N30019 R55718 R60552 N84522 AI143322
AW519024 AA490700 N20675 AW296747 C16068 D58331 C16518 AI141214 N67221 C16423 C16537 C16094 C16152 H28935
T66152 C16362 AW022425 AA602899 AA694603 H22255 W74368 C16356 AI129361 AI917986 AI582253 AI923898 AI038907
AW191970 AI678861 C16429 C16345 AI277790 R42325 AI640420 AI004136 AI277797 C16100 F09836 T71212 AA152316
AW090781 AI055902 T16084 AW022915 C16556 AW473979 T96820 AA476595 N75446 F02570 H69286 T89992 AA907493
T34275 AA156107 H11758 AI650288 H82900 AI474575 N66718 F04914 AA505470 AA993349 F01973 AI123277 F04729 C16236
AA879148 AA029574 AA887046 R08127 D57339 AA490477 AI669818 AI190995 AA035507 AL119272 AL135029 AA258725
AL079521 N40299 AI630191 N86148 AA341165T28492 N83749 AI382123 AI065033 AI950411 AI935653 AI275551 AW027482
AW197337 AI168323 AI336930 AI094099 AI351490 AA258563 AI634763 AI492374 AA983970 AH 23565 T72559 F09890
AA669531 AI445824 T07180 AW084799 AA306254 R60606 W28367 R55928 W27995 AL044845 AA501890 N84045 T97274
N87532 AL135219 AA116056T06000 AA116057 T07181 08126
124677 geπbaπk_R01073 R01073
110243 genbank H26683 H26683
101867 entrez_M_96132 M96132
101941 entrez S77583 S77583
119052 149538 1 R10889 R10888
126452 209811.1 R26867 R27438
119263 genbank_T15977 T15977
112040 genbank_R43286 R43286
103657 entrez_Z73677 Z73677
119400 genbank_T92767 T92767
119554 N0T_F0UND_entrez_W38188 W38188
123130 genbank_AA487200 AA487200
123143 geπbaπk_AA487595 AA487595
121950 genbank_AA429515 AA429515
123265 geπbank-AA491209 AA491209
114988 genbank_AA251089 AA251089
107794 genbank_AA019255 AA019255 123422 genbank_AA598484 AA598484 109062 genbank_AA160941 AA160941
TABLE 4A ABOUT 1164 GENES UPREGULATED IN GLIOBLASTOMA
Pkey Unique Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene title
R1 Ratio of brain tumor to body atlas
R2 Rado of brain tumor to normal brain
Pkey ExAccn UnigenelD Unigene Title R1 R2
412719 AW016610 Hs 129911 ESTs 1178 33
428321 AI699994 Hs 301347 ESTs 1089 39
455601 AI368680 Hs 816 SRY (sex determining region Y) box 2 1075 99
431917 D16181 Hs 2868 peπpheral myeliπ protein 2 990 11 8
415817 U88967 Hs 78867 protein tyrosine phosphatase, receptor-t 720 11 3
449494 AW237014 Hs 288650 aquapoππ 4 600 22
439285 AL133916 Hs 298998 ESTs 582 22
447072 D61594 Hs 17279 tyrosylprotein sulfotransferase 1 542 71
456759 BE259150 Hs 127792 delta (Drosophιla)-lιke 3 535 25
427343 AI880044 Hs 176977 protein kinase C binding protein 2 496 22
425088 AA663372 Hs 169395 Homo sapiens cDNA FLJ 12015 fis, done HE 495 31
412959 D87458 Hs 75090 KIAA0282 protein 463 30
447004 AW296968 Hs 157539 ESTs 437 32
436878 BE465204 Hs 47448 ESTs 398 108
433551 AI985544 Hs 289048 ESTs 397 43
425842 AI587490 Hs 159623 NK-2 (Drosophila) homolog B 39 3 26 2
407034 U84540 gb Human dystrobrevm isoform DTN-3 (DTN 39 1 39 1
431725 X65724 Hs 2839 Nome disease (pseudoglioma) 384 37
453392 U23752 Hs 32964 SRY (sex determining region Y) box 11 375 221
447197 R36075 gb yh88b01 s1 Soares placenta Nb2HP Homo 375 139
439415 F05538 Hs 12825 ESTs 354 31
409395 U46745 Hs 54435 dystrobrevm, alpha 343 30
449539 W80363 Hs 58446 ESTs 336 336
408562 AI436323 HS 31141 Homo sapiens mRNA for KIAA1568 protein, 328 59
431019 NM.005249 Hs 2714 forkhead box G18 324 170
427540 R12014 Hs 20976 ESTs 321 20
425057 AA826434 Hs 96944 ESTs 31 0 23
431941 AK000106 Hs 272227 Homo sapiens cDNA FLJ20099 fis, clone CO 308 30 8
416829 AB013805 Hs 80220 catenm (cadheπn associated protein), d 304 22
420807 AA280627 Hs 57846 ESTs 304 304
444190 A1878918 Hs 10526 cysteine and glycine πch protein 2 304 304
429466 M85835 Hs 12827 ESTs 30 2 72
444471 AB020684 Hs 11217 KIAA0877 protein 295 295
451678 AA374181 Hs 26799 DKFZP564D0764 protein 288 30
439979 AW600291 Hs 6823 hypothetical protein FLJ 10430 277 32
433800 AI034361 Hs 135150 lung type-l cell membrane-associated gly 271 271
440435 AL042201 Hs 21273 ESTs 269 269
411078 AI222020 Hs 182364 ESTs, Weakly similar to 25 kDa trypsin i 260 260
407808 AA663559 Hs 289109 dimethylargiπine dimethylaminohydrolase 25 8 22
416155 AI807264 Hs 205442 ESTs, Weakly similar to AF1176101 inner 255 255
421659 NM.014459 Hs 106511 protocadherin 17 250 33
430132 AA204686 Hs 234149 hypothetical protein FLJ20647 24 7 247
433332 AI367347 Hs 127809 ESTs 246 246
452744 AI267652 Hs 30504 Homo sapiens mRNA cDNA DKFZp434E082 (fr 238 23 8
419271 N34901 Hs 238532 ESTs 236 55
447397 BE247676 Hs 18442 E-1 enzyme 231 32
439039 AI656707 Hs 48713 ESTs 230 72
414175 AI308876 Hs 103849 ESTs 222 20
451099 R52795 Hs 25954 interieukin 13 receptor, alpha 2 220 76
410102 AW248508 Hs 279727 Homo sapiens cDNA FLJ14035 fis, clone HE 21 6 23
415910 U20350 Hs 78913 chemokine (C-X3-C) receptor 1 21 2 30
451468 AW503398 Hs 210047 ESTs 21 0 47
454117 BE410100 Hs 40368 adaptor-related protein complex 1, sigma 20 8 208
443850 AW014723 Hs 134719 ESTs 204 385
418738 AW388633 Hs 6682 ESTs 202 22
449433 AI672096 Hs 9012 ESTs 199 166
435706 W31254 Hs 7045 GL004 protein 197 197
407192 AA609200 gb af12e02s1 Soares.testis.NHT Homo sap 197 197
416892 L24498 Hs 80409 growth arrest and DNA-damage-mducible, 196 196
442562 BE379584 Hs 34789 ESTs 194 194
439451 AF086270 Hs 278554 heterochromatin like protein 1 191 174
426320 W47595 Hs 169300 transforming growth factor, beta 2 187 54
412986 X81120 Hs 75110 cannabmoid receptor 1 (brain) 186 186
452106 AI141031 Hs 21342 ESTs 186 103
431173 AW971198 Hs 294068 ESTs 186 186
422583 AA410506 Hs 118578 H sapiens mRNA for πbosomal protein L18 185 185
419088 AI538323 Hs 77496 small nuclear πbonucleoprotein polypept 185 185
443547 AW271273 Hs 23767 Homo sapiens cDNA FLJ12666 fis, clone NT 185 51
451592 AI805416 Hs 213897 ESTs 184 184
450313 AI038989 Hs 24809 hypothetical protein FLJ10826 183 183 422544 AB018259 Hs 118140 KIAA0716 gene product 182 47
408096 BE250162 Hs 83765 dihydrofolate reductase 180 180
418027 AB037807 Hs 83293 hypothedcal protein 180 82
414117 W88559 Hs 1787 proteolipid protein (Pelizaeus-Merzbache 180 180
429418 AI381028 Hs 99283 ESTs 178 178
432527 AW975028 Hs 102754 ESTs 177 42
447809 AW207605 Hs 164230 ESTs, Highly similar to phosphodiesteras 175 43
419704 AA429104 Hs 45057 ESTs 174 46
436476 AA326108 Hs 53631 ESTs, Weakly similar to enhaπcer-of-spli 174 21
445133 AW157646 Hs 153506 ESTs, Weakly similar to AF150755 1 micro 173 188
446659 AI335361 Hs 226376 ESTs 172 28
409049 AI423132 Hs 146343 ESTs 172 38
443672 AA323362 Hs 9667 butyrobeta e (gamma), 2-oxoglutarate di 172 11 0
407748 AL079409 Hs 38176 KIAA0606 protein, SCN Orcadian Oscillat 170 63
438527 AI969251 Hs 143237 ESTs 169 169
417791 AW965339 Hs 111471 ESTs 168 105
417355 D13168 Hs 82002 endothelm receptor type B 164 164
427897 NM 017413 Hs 181060 apelm, peptide ligand for APJ receptor 163 42
419721 NM 001650 Hs 288650 aquapoπn 4 162 44
427701 AA411101 Hs 221750 ESTs 16 1 39
432435 BE218886 Hs 282070 ESTs 16 1 57
426809 BE313114 Hs 29706 ESTs 160 100
407881 AW072003 Hs 40968 heparan sulfate (glucosamine) 3-O-sulfot 159 159
400859 157 157
409731 AA125985 Hs 56145 thymosin, beta, identified in neuroblast 156 156
420092 AA814043 Hs 88045 ESTs 156 54
449605 AW138581 Hs 198416 ESTs 155 30
422365 AF035537 Hs 115521 REV3 (yeast homolog)-lιke, catalytic sub 153 46
449611 AI970394 Hs 197075 ESTs 152 152
414922 D00723 Hs 77631 glycine cleavage system protein H (am o 152 56
405238 151 28
429007 D80642 gb HUM092E09B Human fetal brain (TFujiwa 150 35
409638 AW450420 Hs 21335 ESTs 149 71
445888 AF070564 Hs 13415 Homo sapiens clone 24571 mRNA sequence 148 57
416737 AF154335 Hs 79691 LIM domain protein 147 42
429163 AA884766 gb am20a10 s1 Soares NFUT GBC S1 Homo s 146 30
436870 AW204219 Hs 43679 ESTs 146 26
443181 AI039201 Hs 54548 ESTs 146 35
436281 AW411194 Hs 120051 ESTs 145 85
449448 D60730 Hs 57471 ESTs 144 48
422564 AI148006 Hs 222120 ESTs 144 144
448243 AW369771 Hs 77496 small nuclear πbonucleoprotein polypept 143 24
428748 AW593206 Hs 98785 ESTs 142 142
452576 AB023177 Hs 29900 KIAA0960 protein 141 81
452461 N78223 Hs 108106 transcπption factor 141 128
449670 F07693 Hs 23869 Homo sapiens mRNA, cDNA DKFZp434K2172 (f 141 141
436637 AI783629 Hs 26766 ESTs 140 23
429597 NM 003816 Hs 2442 a disintegπn and metalloproteinase doma 139 139
419078 M93119 Hs 89584 msulinoma-associated 1 139 29
410889 X91662 Hs 66744 twist (Drosophila) homolog (acrocephalos 139 41
452355 N54926 Hs 29202 G protein-coupled receptor 34 139 139
421452 AI925946 Hs 104530 fetal hypothetical protein 139 139
430290 AI734110 Hs 136355 ESTs 138 138
430387 AW372884 Hs 240770 nuclear cap binding protein subunit 2, 2 136 136
415875 AA894876 Hs 5687 protein phosphatase 1B (formerly 2C), a 135 135
416795 AI497778 Hs 168053 ESTs, Highly similar to AF227948 1 HBV p 135 135
422025 BE348774 Hs 122554 ESTs 133 133
400992 133 55
413174 AA723564 Hs 191343 ESTs 132 25
425187 AW014486 Hs 22509 ESTs 13 1 82
456965 AW131888 Hs 172792 ESTs, Weakly similar to hypothetical pro 13 1 27
419852 AW503756 Hs 286184 hypothedcal protein dJ551D25 130 24
409327 L41162 Hs 53563 collagen, type IX, alpha 3 129 40
439519 AA837118 Hs 118366 ESTs 129 76
436299 AK000767 Hs 5111 hypothetical protein FU20729 127 31
446657 AI335191 Hs 260702 ESTs, Moderately similar to ALU7.HUMAN A 126 126
423073 BE252922 Hs 123119 MAD (mothers against decapentaplegic, Dr 126 126
424278 AK000723 Hs 144517 hypothetical protein FU20716 126 126
451996 AW514021 Hs 245510 ESTs 126 70
400860 125 231
439579 AF086400 gb Homo sapiens full length insert cDNA 124 124
408312 AF263613 Hs 44198 intracellular membrane associated calciu 124 124
419948 AB041035 Hs 93847 NADPH oxidase 4 124 24
427304 AA761526 Hs 163853 ESTs 123 123
419498 AL036591 Hs 20887 hypothetical protein FLJ10392 122 122
428137 AA421792 Hs 170999 ESTs 122 122
432683 AW995441 Hs 10475 ESTs 122 20
408622 AA056060 Hs 202577 Homo sapiens cDNA FLJ12166 fis, clone MA 121 121
453884 AA355925 Hs 36232 KIAA0186 gene product 120 52
441440 AI807981 Hs 30495 ESTs 120 36
414217 AI309298 Hs 279898 Homo sapiens cDNA FLJ23165 fis, clone L 120 627
410227 AB009284 Hs 61152 exostoses (multιple)-lιke 2 11 9 29
439444 AI277652 Hs 54578 ESTs 11 9 16 5 433309 AA807060 Hs 126558 ESTs 11 7 90
439170 AA332365 Hs 165539 ESTs 11 6 97
417160 N76497 Hs 1787 proteolipid protein (Pelizaeus-Merzbache 11 5 72
424668 D83702 Hs 151573 cryptochrome 1 (photolyase-like) 11 5 58
410611 AW954134 Hs 20924 KIAA1628 protein 11 5 282
437124 AA554458 Hs 204200 ESTs 11 5 11 5
418858 AW961605 Hs 21145 Homo sapiens cDNA FU22489 fis, clone H 11 3 11 3
423600 A1633559 Hs 29076 Homo sapiens cDNA FLJ21841 fis, clone H 11 3 28
429393 AA383024 Hs 201603 ESTs, Highly similar to hypothetical pro 11 3 11 3
431103 M57399 Hs44 pleiotrophin (hepann binding growth fac 11 3 34
452092 BE245374 Hs 27842 hypothedcal protein FU11210 11 3 11 7
431701 AW935490 Hs 14658 ESTs 11 3 26
429399 AA452244 Hs 16727 ESTs 11 2 22
408988 AL119844 Hs 49476 Homo sapiens clone TUA8 Cπ-du-chat regi 11 2 278
442671 A1005668 Hs 134779 EST 11 1 11 1
402524 11 1 11 1
415558 AA885143 Hs 125719 ESTs 11 1 11 1
422390 AW450893 Hs 121830 ESTs, Weakly similar to KIAA0924 protein 11 0
418475 A1858732 Hs 30443 sentπn/SUMO-specific protease 11 0 61
458809 AW972512 Hs 20985 sιn3-assocιated polypepdde, 30kD 11 0 56
410297 AA148710 Hs 159441 ESTs 11 0 33
444017 U04840 Hs 214 neuro-oncological ventral antigen 1 110 110
437814 AI088192 Hs 135474 ESTs, Weakly similar to DDX9 HUMAN ATP-D 109 33
427194 AA399018 Hs 250835 ESTs 108 80
432060 AW971364 gb EST383453 MAGE resequences, MAGL Homo 108 100
453861 A1026838 Hs 30120 ESTs 108 108
408829 NM 006042 Hs 48384 heparan sulfate (glucosamine) 3-O-sulfot 106 33
416913 AW934714 gb RC1-DT0001-031299-011-a11 DT0001 Homo 106 34
418049 AA211467 Hs 190488 hypothedcal protem FLJ10120 106 106
413063 AL035737 Hs 75184 chitmase 3-lιke 1 (cartilage glycoprote 106 272
425264 AA353953 Hs 20369 ESTs, Weakly similar to gonadotropin iπd 105 20
434408 AI031771 Hs 132586 ESTs 105 105
451697 AW449774 Hs 257208 ESTs 105 62
436754 A1061288 Hs 133437 ESTs, Moderately similar to gonadotropin 103 103
410298 AI693821 Hs 182185 ESTs 103 29
412766 BE544475 Hs 54347 ESTs 103 103
450689 AI369275 Hs 243010 ESTs, Moderately similar to RTCO.HUMAN G 103 103
408331 NM 007240 Hs 44229 dual specificity phosphatase 12 103 45
442007 AA301116 Hs 142838 Homo sapiens cDNA FLJ23444 fis, clone H 103 103
410386 W26187 Hs 3327 Homo sapiens cDNA FLJ22219 fis, clone H 102 2 1
440684 AI253123 Hs 127356 ESTs, Highly similar to NEST.HUMAN NESTI 10 1 10 1
420892 AW975076 Hs 172589 nuclear phosphoprotein similar to S cer 100 100
419594 AAQ13051 Hs 91417 topoisomerase (DNA) II binding protein 99 158
419972 AL041465 Hs 294038 ESTs, Moderately similar to ALU2.HUMAN A 97 232
433730 AK002135 Hs 3542 hypothetical protein FLJ11273 96 65
434851 AA806164 Hs 116502 ESTs 95 65
436306 AA805939 Hs 117927 ESTs 95 47
453331 AI240665 Hs 8895 ESTs 92 58
414429 R51494 Hs 71818 ESTs 90 62
424998 U58515 Hs 154138 chitmase 3-lιke 2 89 181
446936 H10207 Hs 47314 ESTs 89 36
410276 AI554545 Hs 68301 ESTs 38
453857 AL080235 Hs 35861 DKFZP586E1621 prote 38
448321 NM 005883 Hs 20912 adenomatous polyposis coli like 20
414783 AW069569 Hs 75839 zinc finger protein 6 (CMPX1) 87 30
441079 AW150697 Hs 107418 ESTs 87 22
437517 AI927675 Hs 99858 πbosomal protein L7a 86 45
409062 AL157488 Hs 50150 Homo sapiens mRNA, cDNA DKFZp564B182 (fr 86 122
420630 AL133101 Hs 99508 Homo sapiens mRNA, cDNA DKFZp434O0921 (f 104
409260 AW242407 Hs 18479 ESTs 85 11 6
442343 AA992480 Hs 129874 ESTs 84 46
416439 AA180363 Hs 118769 ESTs 84 72
428054 AI948688 Hs 266619 ESTs 82 92
421633 AF121860 Hs 106260 sorting nexin 10 82 26
433285 AW975944 Hs 237396 ESTs 81 33
433226 AW503733 Hs9414 KIAA1488 protein 80 134
424800 AL035588 Hs 153203 MyoD family inhibitor 80 25
425681 AB018297 Hs 159183 KIAA0754 protein 79 48
445034 AW293376 Hs 160323 ESTs 79 37
435020 AW505076 Hs 301855 DiGeorge syndrome cntical region gene 8 76 64
446985 AL038704 Hs 156827 ESTs, Weakly similar to ALU1.HUMAN ALU S 75 78
446619 AU076643 Hs313 secreted phosphoprotein 1 (osteopondn, 75 39
418522 AA605038 Hs7149 Homo sapiens cDNA FU21950 fis, clone H 7 5 22
439864 AI720078 Hs 291997 ESTs 74 69
419723 AL120193 Hs 92614 Homo sapiens growth differentiation fact 74 35
447896 AI436124 Hs 294069 ESTs, Weakly similar to ORF2 contains a 73 22 1
404210 73 408
436671 AW137159 Hs 146151 ESTs 72 11 8
439231 AW581935 Hs 141480 ESTs 72 25
418030 BE207573 Hs 83321 neuromedin B 71 64
459290 NMJ01546 Hs 34853 inhibitor of DNA binding 4, dominant neg 70 67
423869 BE409301 Hs 134012 C1q related factor 70 49
414825 X06370 Hs 77432 epidermal growth factor receptor (avian 69 64
Figure imgf000120_0001
417022 NM.014737 Hs 80905 Ras association (RalGDS/AF-6) domain fam 68 25
405239 U89281 Hs 11958 oxidative 3 alpha hydroxysteroid dehydro 68 29
433577 AW007080 Hs 8817 ESTs 66 26
434629 AA789081 Hs 4029 glioma-amplified sequence-41 66 139
413886 AW958264 Hs 103832 ESTs, Weakly similar to TRHY HUMAN TRICH 66 22
451460 AI797550 Hs 209652 ESTs 65 137
442145 AI022650 Hs 8117 erbb2 interacting protein ERBIN 65 156
437273 AL137451 Hs 120873 ESTs, Highly similar to hypothedcal pro 65 24
418365 AW014345 Hs 161690 ESTs 64 128
421684 BE281591 Hs 106768 hypothedcal protein FU10511 64 43
449458 AI805078 Hs 208261 ESTs 64 23
426413 AA377823 gb EST90805 Synovial sarcoma Homo sapien 63 132
426423 NM 012446 Hs 169833 single-stranded-DNA-bmdmg protein 63 109
417709 D87434 Hs 82426 KIAA0247 gene product 63 233
448499 BE613280 Hs 250655 prothymosin, alpha (gene sequence 28) 62 29
444880 AW118683 Hs 154150 ESTs 62 194
432715 AA247152 Hs 200483 ESTs, Weakly similar to KIAA1074 protein 62 127
444864 AW965446 Hs 46637 ESTs, Weakly similar to cDNA EST yk289g5 62 41
407792 AI077715 Hs 39384 putative secreted ligand homologous to f 62 34
431962 AL049385 Hs 272251 Homo sapiens mRNA, cDNA DKFZp586M1418 (f 61 26
424232 AB015982 Hs 143460 protein kinase C, nu 6 1 146
436443 AW138211 Hs 128746 ESTs 61 28
433647 AA603367 Hs 222294 ESTs 6 1 150
449961 AW265634 Hs 133100 ESTs 61 34
448704 AW080932 Hs 249247 heterogeneous nuclear protein similar to 6 1 61
408393 AW015318 Hs 23165 ESTs 6 1 21 6
450693 AW450461 Hs 203965 ESTs 6 1 2.2
407846 AA426202 Hs 40403 Cbp/p300 mteracdng transacdvator, wit 60 24
445817 NM 003642 Hs 13340 histone acetyltransferase 1 60 109
440650 R44692 Hs 6640 ESTs 60 21
417675 AI808607 Hs 3781 similar to murine leucine-nch repeat pr 60 24
411083 N41340 Hs 68318 hypothetical protein FLJ20344 60 36
407910 AA650274 Hs 41296 fibronectin leucine πch transmembrane p 60 60
402855 60 26
445594 AW058463 Hs 12940 zinc-fingers and homeoboxes 1 60 11 6
418791 AA935633 Hs 194628 ESTs 59 67
409262 AK000631 Hs 52256 hypothetical protein FLJ20624 59 23
435677 AA694142 Hs 293726 ESTs 59 11 8
430334 AI824719 Hs 47557 ESTs 59 75
452834 AI638627 Hs 105685 ESTs 59 26
427315 AA179949 Hs 175563 Homo sapiens mRNA, cDNA DKFZp564N0763 (f 58 31
428250 AW809208 Hs 183297 DKFZP566F2124 protein 58 20
418506 AA084248 Hs 85339 G protein-coupled receptor 39 58 25
417115 AW952792 Hs 1066 small nuclear nbonucleoprotein polypept 58 160
436758 AW977167 Hs 155272 ESTs 58 38
446332 AK001635 Hs 14838 hypothetical protein FU10773 57 51
423943 AF163570 Hs 135756 polymerase (DNA-directed) kappa 57 11 1
428180 AU 29767 Hs 182874 Homo sapiens cDNA FLJ21929 fis, clone H 56 71
424343 AW956360 Hs 4748 ESTs, Highly similar to JN0902 pituitary 56 22
417318 AW953937 Hs 12891 ESTs 56 250
423582 BE000831 Hs 23837 Homo sapiens cDNA FLJ11812 fis, clone HE 56 41
427472 AA522539 Hs 131250 traπsposon-deπved Buster3 transposase I 54 35
434701 AA460479 Hs 4096 KIAA0742 protein 54 21 2
430147 R60704 Hs 234434 hairy/enhancer-of-split related with YRP 53 27
411019 AW993097 Hs 48617 Homo sapiens cDNA FU12540 fis, clone NT 53 41
424939 AK000059 Hs 153881 Homo sapiens NY-REN 62 antigen mRNA, par 53 24
424028 AF055084 Hs 153692 KIAA0686 protein 53 27
444534 AW271626 Hs 42294 ESTs 53 21
426171 AI128606 Hs 301454 ESTs 52 38
431843 AA516420 Hs 183526 ESTs 52 62
438204 AI589645 Hs 128690 ESTs 52 58
424635 AA420687 Hs 115455 Homo sapiens cDNA FLJ14259 fis, clone PL 52 84
436223 AK001884 Hs 23799 ESTs 52 24
450649 NM.00142Ϊ ) Hs 297722 Human DNA sequence from clone RP1-85F18 52 153
441689 A1123705 Hs 106932 ESTs 52 22
443392 AI055821 Hs 293420 ESTs 51 33
416179 R19015 Hs 79067 MAD (mothers against decapentaplegic, Dr 51 167
452167 N75238 Hs 13075 Homo sapiens cDNA FLJ23013 fis, clone L 51 187
434001 AW950905 Hs 3697 senne (or cysteine) proteinase mhibito 50 24
458435 AI418718 Hs 144121 ESTs, Weakly similar to dJ37E162 [H sap 50 39
433586 T85301 gb yd78d06 s1 Soares fetal liver spleen 50 28
452040 AW973242 Hs 293690 ESTs 50 45
404029 50 43
421141 AW117261 Hs 125914 ESTs 50 21
402605 49 42
435839 AF249744 Hs 25951 Rho guanine nucleotide exchange factor ( 49 25
416404 AA180138 Hs 107924 ESTs 49 24
435615 Y15065 Hs 4975 potassium voltage-gated channel, KQT-lik 49 72
448425 AI500359 Hs 233401 ESTs 49 49 445773 H73456 Hs 13299 Homo sapiens mRNA, cDNA DKFZp761M0111 (f 49 29
448451 AW015994 gb UI-H-BIOp-abh-g 09-0-Ul s1 NCI CGAP S 49 22
444838 AV651680 Hs 208558 ESTs 48 67
452438 BE514230 Hs 29595 JM4 protein 48 27
443898 AW804296 Hs 9950 Sec61 gamma 48 72
452776 AA194540 Hs 13522 ESTs 48 34
426108 AA622037 Hs 166468 programmed cell death 5 48 167
416774 A1005169 Hs 28274 Homo sapiens cDNA FLJ22049 fis, clone H 48 32
427704 AW971063 Hs 292882 ESTs 48 238
433588 AI056872 Hs 133386 ESTs 48 128
410108 AA081659 Hs 191098 KIAA1479 protein 47 21
433556 W56321 Hs 111460 Homo sapiens cDNA FU21715 fis, clone C 47 11 2
418962 AA714835 Hs 271863 ESTs 47 22
404049 47 30
436222 AI208737 Hs 122810 Homo sapiens cDNA FU11489 fis, clone HE 47 33
425234 AW152225 Hs 165909 ESTs 47 31
426490 NM.001621 Hs 170087 aryl hydrocarbon receptor 47 91
426514 BE616633 Hs 301122 bone moφhogenehc protein 7 (osteogenic 47 27
428722 U76456 Hs 190787 dssue inhibitor of metalloproteinase 4 46 67
451989 AF169797 Hs 27413 adaptor protein containing pH domain, PT 46 134
412490 AW803564 Hs 288850 Homo sapiens cDNA FU22528 fis, clone H 46 184
422488 AI679968 Hs 152060 ESTs 46 77
428862 NM.000346 Hs 2316 SRY (sex-determining region Y)-box 9 (ca 46 46
413724 AA131466 Hs 23767 Homo sapiens cDNA FLJ12666 fis, clone NT 45 11 9
442495 A1184717 gb qd64b01 x1 Soares.tesds.NHT Homo sap 45 45
403549 45 11 6
456209 W60633 Hs 297792 ESTs 45 5 1
421181 NM 005574 Hs 184585 LIM domain only 2 (rhombodn-like 1) 45 106
439566 AF086387 gb Homo sapiens full length insert cDNA 44 26
446329 NM 013272 Hs 14805 solute earner family 21 (organic anion 44 17 2
446488 AB037782 Hs 15119 KIAA1361 protein 44 84
426110 NM 002913 Hs 166563 replication factor C (activator 1) 1 (14 44 25
427413 BE547647 Hs 177781 superoxide dismutase 2, mitochondrial 44 143
424340 AA339036 Hs 7033 ESTs 44 39
421552 AF026692 Hs 105700 secreted fπzzled-related protem 4 43 31 1
422033 AW245805 Hs 110903 claudm 5 (transmembrane protein deleted 43 61
434476 AW858520 Hs 271825 ESTs 43 45
420582 BE047878 Hs 99093 Homo sapiens chromosome 19, cosmid R2837 43 36
419904 AA974411 Hs 18672 ESTs 43 1 1
407939 W05608 gb za85e07 r1 Soares fetal.lung NbHL19W 43 90
425836 AW955696 Hs 94842 ESTs 43 32
426304 AA374532 Hs 297985 ESTs 43 66
439653 AW021103 Hs 6631 hypothedcal protein FLJ20373 43 23
424723 BE409813 Hs 152337 protein arginine N-methyltransferase 3(h 43 25
426064 BE387014 Hs 166146 Homer, neuronal immediate early gene, 3 42 41
409509 AL036923 Hs 127006 ESTs 42 164
424391 BE55Q112 Hs 112712 ESTs 42 38
425248 AW957442 Hs 252766 ESTs 42 11 1
41B259 AA215404 Hs 137289 ESTs 42 193
445525 BE149866 Hs 14831 ESTs 42 31
414821 M63835 Hs 77424 Fc fragment of IgG, high affinity la, re 42 348
430935 AW072916 Hs 115654 ESTs 42 30
442233 AW967149 Hs 28439 ESTs, Weakly similar to ORF2 [M musculus 42 24
416959 D28459 Hs 80612 ubiquitin-conjugating enzyme E2A (RAD6 h 41 153
437097 N45312 Hs 46506 ESTs 41 156
428189 AA424030 Hs 46627 ESTs 41 36
434963 AW974957 Hs 288719 Homo sapiens cDNA FLJ12142 fis, clone MA 41 122
425500 AB011541 Hs 158200 EGF-like-domam, muldple 4 4 1 28
43S177 AI018174 Hs 2936 ESTs 41 2 1
418357 Z44718 Hs 301010 ESTs, Highly similar to AF159851 1 Rho G 41 4 1
419086 NM 000216 . Hs 89591 Kallmaππ syndrome 1 sequence 41 4 1
436557 W15573 Hs 5027 ESTs 40 21
425588 F07396 Hs 46751 ESTs 40 22
423905 AW579960 Hs 135150 lung type-1 cell membrane-associated gly 40 36
437095 D14661 Hs 119 Wilms' tumour 1-assocιatιng protein 40 100
425332 AA633306 Hs 127279 ESTs 40 109
431556 AF016028 Hs 260039 sarcospan (Kras oncogene-associated gene 40 38
427209 H06509 Hs 92423 KIAA1566 protein 40 3 1
435468 AW362803 Hs 166271 ESTs 40 22
416773 AK000340 Hs 79828 hypothedcal protein FLJ20333 40 26
440483 AI200836 Hs 150386 ESTs 40 25
444821 AA053564 Hs 12040 STE20-lιke kinase 40 104
433873 AW156913 Hs 150478 ESTs, Weakly similar to KIAA0987 protein 40 23
420028 AB014680 Hs 8786 carbohydrate (choπdroidn 6/keratan) sul 39 28
446706 AW807631 Hs 190488 hypothedcal protein FU10120 39 38
424530 AI632083 Hs 28511 ESTs 39 22
446851 AW007332 Hs 16261 Homo sapiens cDNA FU22063 fis, clone H 39 160
424720 M89907 Hs 152292 SWI/SNF related, matnx associated, acd 39 45
409456 U34962 Hs 54473 cardiac-specific homeo box 39 80
420439 AW270041 Hs 193053 eukaryotic transladon initiation factor 39 79
447340 AW961327 Hs 280833 ESTs 39 21
430887 N66801 Hs 260287 ESTs, Weakly similar to ALU7.HUMAN ALU S 39 25
409361 NM Q5982 Hs 54416 sine oculis homeobox (Drosophila) homolo 39 46 426509 M31166 Hs 2050 pentaxm related gene, rapidly induced b 39 40
410079 U94362 Hs 58589 glycogenm 2 39 18 3
426818 AA554827 Hs 124841 ESTs, Weakly similar to ALU5.HUMAN ALU S 39 30
435232 NM 001262 Hs 854 cyclin-depeπdent kinase inhibitor 2C (p1 38 40
427228 AA115770 Hs 174051 small nuclear nbonucleoprotein 70kD pol 38 79
443801 AW206942 Hs 253594 ESTs 38 34
450746 D82673 Hs 169921 general transcπpdon factor II, i, pseu 38 22
443837 A1984625 Hs 9884 spindle pole body protein 38 65
435760 AF231922 Hs 213004 chromosome 21 open reading frame 62 38 22
426757 AW205640 Hs 158206 ESTs 37 3 1
443101 AI268936 Hs 129872 sperm surface protein 37 24
440118 AB040893 Hs 6968 KIAA1460 protein 37 35
410612 AW502698 Hs 118152 ESTs 37 225
435869 AF255910 Hs 54650 vascular endothelial juncdon-associaled 37 42
433208 AW002834 Hs 24095 ESTs 37 160
432357 AA452506 Hs 274412 similar to yeast Upf3, vanant A 37 26
413916 N49813 Hs 75615 apolipopratem C-il 37 54
429766 AA612710 Hs 146140 ESTs 37 32
437470 AL390147 Hs 134742 hypothetical protein DKFZp547D065 37 64
438459 T49300 Hs 35304 Homo sapiens cDNA FU13655 fis, clone PL 37 107
420361 N92054 Hs 206910 ESTs 37 187
408819 AW163483 Hs 48320 DKFZP566B1346 protein 37 88
411960 R77776 Hs 18103 ESTs 37 23
435923 BE301930 Hs 5010 Homo sapiens clone 24672 mRNA sequence 37 22
440145 AW021433 Hs 250863 ESTs 37 38
453740 AL120295 gb DKFZp761M067_s1 761 (synonym hamy2) 36 30
440975 AW499914 Hs 7579 hypothetical protein FU 10402 36 20
443135 AI376331 Hs 156103 ESTs 36 124
419687 AI638859 Hs 227699 ESTs, Weakly similar to Yhr217cp [S cere 36 2.7
451029 AA852097 Hs 25829 ras-related protein 36 29
414512 AL044336 Hs 6831 golgi resident protein GCP60 36 105
410853 H04588 Hs 30469 ESTs 36 23 9
419900 AI469960 Hs 170698 ESTs 36 36
429673 AA884407 Hs 211595 protein tyrosine phosphatase, non recept 36 75
428290 AI932995 Hs 183475 Homo sapiens clone 25061 mRNA sequence 36 96
444381 BE387335 Hs 283713 ESTs, Weakly similar to CA54.HUMAN COLLA 36 49
442104 L20971 Hs 188 phosphodiesterase 4B, cAMP-specific (dun 36 21
441269 AW015206 Hs 178784 ESTs 36 28
447961 W32791 Hs 170405 ESTs 35 46
447735 AA775268 Hs 6127 Homo sapiens cDNA FU23020 fis clone L 35 2 1
437580 AA761075 Hs 293567 ESTs 35 35
447710 AI420523 Hs 161282 ESTs 35 35
436446 AW016809 Hs 119021 ESTs 35 22
448412 AI219083 Hs 42532 ESTs, Moderately similar to ALU8 HUMAN A 35 41
409712 AA167385 Hs 13583 ESTs 35 38
404048 35 32
440516 S42303 Hs 161 cadheπn 2, type 1, N-cadheππ (neuronal 35 5 1
409342 AU077058 Hs 54089 BRCA1 associated RING domain 1 35 106
456508 AA502764 Hs 123469 ESTs, Weakly similar to AF208855 1 BM 01 35 38
426101 AL049987 Hs 166361 Homo sapiens mRNA cDNA DKFZp564F112 (fr 35 322
436252 AI539519 Hs 120969 Homo sapiens cDNA FLJ 11562 fis, clone HE 35 46
433854 AA610649 gb np95c03 s1 NCI CGAP.Thyl Homo sapiens 35 35
408495 W68796 Hs 237731 ESTs 35 6 1
418801 AA228366 Hs 115122 ESTs 35 5 1
422493 AW474183 Hs 233816 ESTs 35 152
428141 D50402 Hs 182611 solute earner family 11 (proton-coupled 35 24
414591 AI888490 Hs 55902 ESTs 35 83
439627 BE621702 Hs 29076 Homo sapiens cDNA FLJ21841 fis, clone H 35 302
444969 A1203334 Hs 160628 ESTs 35 3 1
435370 AI964074 Hs 225838 ESTs 35 30
443228 W24781 Hs 293798 ESTs 34 46
414612 BE274552 Hs 76578 protein inhibitor of activated STAT3 34 50
437410 AW023340 Hs 14880 ESTs 34 27
444172 BE147740 Hs 104558 ESTs 34 129
428484 AF104032 Hs 184601 solute carrier family 7 (cationic ammo 34 28
437860 AA333063 Hs 279898 Homo sapiens cDNA FU23165 fis, clone L 34 40
428776 AW016636 Hs 155647 ESTs, Highly similar to R29144 1 [H sapi 34 25
409493 AA386192 Hs 193482 ESTs 34 34
432559 AW452948 Hs 257631 ESTs 34 63
451455 AI937227 Hs 8821 liver-expressed antimicrobial pepdde 34 61
444153 AK001610 Hs 10414 hypothetical protein FU10748 34 26
422872 BE326786 Hs 187646 ESTs 34 22
414761 AU077228 Hs 77256 enhancer of zeste (Drosophila) homolog 2 34 26
416131 L03532 Hs 79024 heterogeneous nuclear πbonucleoprotein 34 95
408576 NM 00354; > Hs 46423 H4 histone family, member G 34 34
431770 BE221880 Hs 268555 5-3 exoπbonuclease 2 34 21 2
426030 BE243933 Hs 108642 zinc finger protein 22 (KO 15) 34 2 1
422573 AW297985 Hs 28777 H2A histone family, member L 34 37
436865 AW880358 Hs 190488 hypothetical protein FLJ10120 34 76
442091 ,AW770493 Hs 195904 guanine nucleotide binding protein (G pr 34 29
418699 BE539639 Hs 173030 ESTs, Weakly similar to ALU8.HUMAN ALU S 34 55
434577 R37316 Hs 179769 Homo sapiens cDNA FLJ22487 fis, clone H 34 39
430314 AA369601 Hs 239138 pre B-cell colony-enhancing factor 34 168 447279 AA325308 Hs 18016 Homo sapiens mRNA, cDNA DKFZp586H0324 (f 33 30
410020 T86315 Hs 728 πboπuctease, RNase A family, 2 (liver, 33 58
447272 NM 014827 Hs 17969 KIAA0663 gene product 33 134
407656 AW747986 Hs 37443 Homo sapiens mRNA, cDNA DKFZp434B2119 (f 33 23
435354 AA678267 Hs 117115 ESTs 33 55
443884 N20617 Hs 226627 lepdn receptor 33 86
444984 H15474 Hs 12214 Homo sapiens clone 23716 mRNA sequence 33 20
431053 S40369 Hs 249141 Glutamate receptor subunit 33 24
424682 AW604804 Hs 151717 KIAA0437 protein 33 137
457972 AI419060 Hs 47448 ESTs 33 42
424762 AL119442 Hs 183684 eukaryodc translation initiation factor 33 32
438666 AW014493 Hs 126727 ESTs 33 10 8
447796 AW953622 Hs 223025 RAB31 , member RAS oncogene family 33 42
426751 W92744 Hs 22664 ESTs 33 26
436251 BE515065 Hs 5092 nucleolar protein (KKE/D repeat) 33 39
452688 AA721140 Hs 49930 ESTs, Weakly similar to 834087 hypotheti 33 49
416359 AL042210 Hs 16493 hypothedcal protein DKFZp762N2316 33 42
424090 X99699 Hs 139262 XIAP associated factor-1 33 29
434987 AW975114 Hs 293273 ESTs 33 22
428642 NM.014899 Hs 188006 KIAA0878 protein 33 57
420372 AW960049 Hs 293660 ESTs, Weakly similar to A49618 probable 33 55
422224 NMJ-13982 Hs 113264 neuregulin 2 32 30
432482 L19267 Hs 275924 dystrophia myotonica-conta ing WD repea 32 27
439963 AW247529 Hs 6793 plalelet-acdvadng factor acetylhydrola 32 20
428418 AI368826 Hs 30654 ESTs 32 24
416728 AB024597 Hs 79658 casein kinase 1, epsilon 32 28
416224 NM 002902 Hs 79088 reticulocalbin 2, EF-haπd calcium bindin 32 22
429803 W81489 Hs 223025 RAB31, member RAS oncogene family 32 43
431387 AI878854 Hs 252229 v-maf musculoaponeurotic fibrosarcoma (a 32 28
404171 32 358
435575 AF213457 Hs 44234 Iπggenng receptor expressed on myeloid 32 26
426421 AW367884 Hs 169832 zinc finger protein 42 (myeloid specific 32 38
445070 NM 000677 Hs 258 adenosine A3 receptor 32 76
407047 X65965 gb H sapiens SOD-2 gene for manganese su 32 820
446006 NM 004403 Hs 13530 deafness, autosomal dominant 5 32 22
430890 X54232 Hs 2699 glypican 1 32 43
439807 AA376417 Hs 173501 Homo sapiens mRNA for FLJ00008 protein, 32 23
430412 AW341754 Hs 189305 ESTs 32 20
442807 AL049274 Hs 8736 Homo sapiens mRNA, cDNA DKFZp564H203 (fr 32 27
420253 AI656055 Hs 96200 neighbor of A-kinase anchonπg protein 9 32 29
436042 AF284422 Hs 119178 cation-chloride cotraπsporter interacdn 32 46
423422 AC005175 Hs 128425 NY-REN-24 antigen 32 40
413020 R98736 gb yr31 h09 r1 Soares fetal liver spleen 32 41
452877 AI250789 Hs 32478 ESTs 32 40
418113 AI272141 Hs 83484 SRY (sex determining region Y) box 4 3 1 90
421097 AI280112 Hs 125232 Homo sapiens cDNA FLJ13266 fis, clone OV 31 20
450219 AI826999 Hs 224624 ESTs 3 1 237
434256 AI378817 Hs 191847 ESTs 3 1 34
421407 T82331 Hs 127453 ESTs 31 39
451198 AW964541 Hs 11500 Homo sapiens cDNA FLJ21127 fis, clone C 3 1 39
445664 AW968638 Hs 237691 ESTs 31 79
411089 AA456454 Hs 118637 Homo sapiens cDNA FLJ13365 fis, clone PL 3 1 60
458050 AA834708 gb od99d04 s1 NCI_CGAP_Ov2 Homo sapiens 31 44
454140 AB040888 Hs 1793 hypothetical protein FU10474 3 1 27
417270 AA429615 Hs 98593 Homo sapiens cDNA FLJ23233 fis, clone C 31 24
427951 AI826125 Hs 43546 ESTs 31 23
443693 AI344782 Hs 9683 protein kinase, interferon inducible dou 31 72
413367 NM 006517 ' Hs 75317 solute earner family 16 (monocarboxylic 31 26
429402 AF116571 Hs 201671 SRY (sex determining region Y)-box 13 3 1 65
447752 M73700 Hs 347 lactotransferπn 3 1 194
408949 AF189011 Hs 49163 putative πbonuclease III 31 37
418039 R06859 Hs 193172 ESTs 31 38
447343 AA256641 Hs 236894 ESTs, Highly similar to LRP1.HUMAN LOW-D 31 22
424441 X14850 Hs 147097 H2A histone family, member X 31 32
435163 AA668884 Hs 19155 ESTs 3 1 21
428712 AW085131 Hs 190452 KIAA0365 gene product 3 1 27
434542 AA769310 Hs 61260 hypothetical protein FLJ 13164 3 1 143
428147 AW629965 Hs 234983 ESTs 31 27
415825 Y18024 Hs 78877 inositol 1,4,5-tπsphosphate 3-kιπase 8 31 25
422170 AI791949 Hs 112432 and Mulleπan hormone 31 81
448801 N57423 Hs 179898 HSPC055 protein 30 20
413542 BE295928 Hs 75424 inhibitor of DNA binding 1 , dominant πeg 30 183
431562 AI884334 Hs 11637 ESTs 30 39
410274 AA381807 Hs 61762 hypoxia-mducible protein 2 30 30
458962 NM 005859 Hs 25180 purine πch element binding protem A 30 30
436277 R88520 Hs 120917 ESTs 30 27
453288 AW583292 Hs 274412 similar to yeast Upf3, vanant A 30 30
447471 AF039843 Hs 18676 sprouty (Drosophila) homolog 2 30 41
442554 AW467376 Hs 129640 ESTs 30 47
441466 AW673081 Hs 54828 ESTs 30 30
420297 A1628272 Hs 88323 ESTs 30 81
445101 T75202 Hs 12314 Homo sapiens mRNA, cDNA DKFZp586C1019 (f 30 187
453405 AI567972 Hs 49919 ESTs 30 96 434521 NM .02267 Hs 3886 karyopheππ alpha 3 (importin alpha 4) 30 93
447948 AI620923 Hs 46679 ESTs 30 101
445756 AA290690 Hs 288493 ESTs 30 35
413243 AA769266 Hs 193657 ESTs 30 59
422845 AA317841 Hs 301838 ESTs, Weakly similar to ALU1 HUMAN ALU S 30 22
419409 AW297831 Hs 143792 ESTs 30 21
446441 AK001782 Hs 15093 hypothetical protein 30 21
427150 BE616183 Hs 173737 ras related C3 botulmum toxin substrate 30 41
421043 BE379455 Hs 89072 ESTs 30 30
427239 BE270447 Hs 174070 ubiquitin earner protein 30 41
433312 AI241331 Hs 131765 ESTs 30 11 0
415102 M31899 Hs 77929 excision repair cross-complementing rode 30 60
414702 L22005 Hs 76932 cell division cycle 34 30 33
428673 AW601325 Hs 274472 high-mobility group (noπhistone chramoso 30 158
422676 D28481 Hs 1570 histamiπe receptor HI 30 21
451693 BE220445 Hs 279635 ESTs 30 23
412420 AL035668 Hs 73853 bone morphogenedc protein 2 30 105
424005 AB033041 Hs 137507 KIAA1215 protein 30 39
440769 BE561793 gb 601346842F1 NIH_MGC_8 Homo sapiens cD 30 51
428832 AA578229 gb n!22b12 s1 NCI.CGAP.HSC1 Homo sapiens 30 23
430293 AI416988 Hs 238272 inositol 1,4,5-tπphosphate receptor, ty 30 63
450883 NM.001348 Hs 25619 death-associated protein kinase 3 30 56
407879 AA045464 Hs 6557 ESTs 29 70
426167 AF039023 Hs 167496 Homo sapiens cDNA FU 11120 fis, clone PL 29 26
435281 AB020699 Hs 4864 KIAA0892 protein 29 39
432339 AW411259 Hs 25945 ESTs 29 29
440524 R71264 Hs 16798 ESTs 29 97
408083 BE383668 Hs 42484 hypothetical protein FU10618 29 44
427729 AB033100 Hs 300646 Homo sapiens cDNA FLJ11744 fis, clone HE 29 31
422072 AB018255 Hs 111138 KIAA0712 gene product 29 29
435904 AF261655 Hs 8910 1,2-alpha-mannosιdase IC 29 36
440100 BE382685 Hs 158549 ESTs 29 36
448356 AL120837 Hs 20993 high glucose regulated protein 8 29 13 9
428005 AW302245 Hs 181390 casein kmase 1, gamma 2 29 37
403019 AA834626 Hs 66718 RAD54 (S cerevιsιae)-lιke 29 58
419175 AW270037 Hs 179507 KIAA0779 protein 29 23
433592 NMJ-04642 Hs 3436 deleted in oral cancer (mouse, homolog) 29 23
413922 AI535895 Hs 221024 ESTs 29 28
428593 AW207440 Hs 185973 degenerative spermatocyte (homolog Droso 29 33
441789 D52059 Hs 7972 KIAA0871 protein 29 2 1
459107 AA811881 Hs 28505 ubiquitm-conjugating enzyme E2H (homolo 29 28
448560 BE613183 Hs 23213 ESTs 29 30
425304 AA463844 Hs 31339 fibroblast growth factor 11 29 33
434846 AW295389 Hs 119768 ESTs 29 5 1
408146 R45621 Hs 81057 ESTs, Moderately similar to CL3BC [R nor 29 5 1
446644 NM 003272 Hs 15791 transmembrane 7 superfamily member 1 (up 29 28
446808 AA703226 Hs 16193 Homo sapiens mRNA, cDNA DKFZp586B211 (fr 29 85
433017 Y15067 Hs 279914 zinc finger protein 232 29 22
429500 X78565 Hs 289114 hexabrachion (tenascin C, cytotactm) 29 45
444706 AK000398 Hs 11747 hypothetical protein FU20391 29 36
407925 BE002320 Hs 287864 Homo sapiens cDNA FLJ14030 fis, clone HE 29 21
431730 AF208856 Hs 268122 hypothetical protein 29 25
447118 AB014599 Hs 17411 KIAA0699 protein 28 21
453496 AA442103 Hs 33084 solute earner family 2 (facilitated glu 28 74
425227 H84455 Hs 40639 ESTs 28 23
456534 X91195 Hs 100623 phospholipase C, beta 3, neighbor pseudo 28 76 2
421465 AK001020 Hs 104627 Homo sapiens cDNA FU10158 fis, clone HE 28 61
409095 AW337272 Hs 293656 ESTs 28 340
424066 Z99348 Hs 112461 ESTs 28 21
432945 AL043683 Hs 271357 ESTs, Weakly similar to unnamed protein 28 11 9
414079 H19184 Hs 205230 ESTs 28 21
414359 M62194 Hs 75929 cadhenn 11, type 2, OB-cadhenn (osteob 28 39
438890 AA827756 Hs 135049 ESTs 28 49
430354 AA95481Q Hs 239784 human homolog of Drosophila Scnbble 28 52
458367 AA088470 Hs 83135 p53-responsιve gene 6 28 44
412014 AI620650 Hs 43761 ESTs 28 48
428727 AF078847 Hs 191356 general transcπption factor HH polype 28 67
447942 F12628 Hs 155470 zinc finger protein 38 (KOX 25) 28 22
426432 AF001601 Hs 169857 paraoxonase 2 28 35
439189 AI951185 Hs 144630 nuclear receptor subfamily 2, group F, m 28 25
446756 AW028485 Hs 26136 ESTs 28 4 1
432148 AW504912 Hs 81907 ESTs, Moderately similar to ALU4.HUMAN A 2.8 26
405649 28 38
414473 BE302693 gb ba74c02 y1 NIH MGC.20 Homo sapiens cD 28 24
443839 AW139834 Hs 143321 ESTs 28 21
448804 AW512213 Hs 42500 ADP-πbosyladon factor-like 5 28 27
426825 AL133415 Hs 2064 vimendn 28 250
417528 H47315 Hs 27519 ESTs 28 11 6
453657 W23237 Hs 296162 ESTs 28 32
432714 Y12059 Hs 278675 bromodomain-containing 4 28 67
441072 AW275480 Hs 39504 ESTs 27 27
441297 AW403084 Hs 7766 ubiquitiπ-conjugatmg enzyme E2E 1 (homo 27 22
443849 BE566066 Hs 9893 ASB-3 protein 27 30 408243 Y00787 Hs 624 interieukin 8 27 38
446243 BE296396 Hs 14512 Homo sapiens cDNA FU11761 fis, clone HE 27 33
432238 AL133057 Hs 274135 Homo sapiens mRNA, cDNA DKFZp434K1815 (f 27 30
433944 AL117518 Hs 3686 KIAA0978 protein 27 31
411400 AA311919 Hs 69851 GAR1 protein 27 160
436840 AW450376 Hs 130803 ESTs, Highly similar to T00367 hypotheti 27 4 1
428281 AA194554 Hs 183434 ATPase, H+ transporting, lysosomal (vacu 27 32
426340 Z97989 Hs 169370 FYN oncogene related to SRC, FGR, YES 27 20
408320 AI125867 Hs 20734 ESTs 27 47
422363 T55979 Hs 115474 replication factor C (activator 1) 3 (38 27 22
436440 AI471862 Hs 196008 Homo sapiens cDNA FU11723 fis, clone HE 27 47
408912 AB011084 Hs 48924 KIAA0512 gene product 27 21
419304 AI271326 Hs 146101 ESTs 27 34
415045 AA321559 Hs 38270 Homo sapiens cDNA FLJ20984 fis, clone C 27 23
441872 BE567100 Hs 154938 hypothetical protein MDS025 27 23
422343 AI628633 gb ty77d05x1 NCI CGAP_Kιd11 Homo sapien 27 25
415539 AI733881 Hs 72472 ESTs 27 27
443823 BE089782 Hs 9877 hypothetical protein 27 47
419881 AA329340 Hs 44649 ESTs 27 33
429155 BE242291 Hs 197540 hypoxia inducible factor 1, alpha subuni 27 55
431319 AA873350 gb oh64h02 s1 NCI.CGAP.Kid5 Homo sapiens 27 659
430219 X99209 Hs 235887 HMT1 (hnRNP methyltransferase, S cerevi 27 31
421016 AA504583 Hs 101047 transonption factor 3 (E2A immunoglobul 27 52
417259 AW903838 Hs 81800 chondroidn sulfate proteoglycaπ 2 (vers 27 107
431747 AW979134 Hs 10700 hypothetical protein 27 29
408085 N25929 Hs 42500 ADP-πbosyladon fxtor-like 5 27 78
426218 AF119043 Hs 168005 transcπpdonal intermediary factor 1 ga 27 45
434845 BE267057 Hs 4200 hypothedcal protein R32184.1 27 46
451644 N23235 Hs 30567 ESTs 27 23
428408 W74437 Hs 188757 Homo sapiens mRNA, cDNA DKFZp564M113 (fr 27 57
446627 AI973016 Hs 15725 hypothedcal protein SBBI48 27 29
450167 AA446404 Hs 24563 NTF2-related export protein 1 27 99
408821 AL050385 Hs 48332 NIMA (never in mitosis gene a) related k 27 21
452068 W76412 Hs 57877 ESTs 27 2 1
431129 All 37751 Hs 263671 Homo sapiens mRNA, cDNA DKFZp434l0812 (f 27 62
429025 AI399910 Hs 4842 ESTs 27 29
421114 AW975051 Hs 293156 ESTs 27 88
428755 D87454 Hs 192966 KIAA0265 protein 27 30
416391 AI878927 Hs 79284 mesoderm specific transcπpt (mouse) horn 27 57
414283 AW960011 Hs 154993 ESTs 27 59
425262 D87119 Hs 155418 GS3955 protein 27 37
447726 AL137638 Hs 19368 Homo sapiens mRNA, cDNA DKFZp434J065 (fr 27 143
424623 AW963062 Hs 165809 ESTs 27 56
444772 AW450800 Hs 176859 ESTs 27 27
428419 U49436 Hs 286236 eukaryotic translation initiation factor 27 46
441049 W88920 Hs 29341 hypothetical protein FLJ22376 27 45
412758 Y07818 Hs 74566 dihydropynmidinase like 3 26 51
447720 AL038765 Hs 161304 ESTs 26 32
419708 AK000753 Hs 92374 hypothetical protein 26 30
445502 AW379160 Hs 12813 DKFZP434J214 protein 26 50
437370 AL359567 Hs 161962 Homo sapiens mRNA, cDNA DKFZp547D023 (fr 26 29
444147 AB002306 Hs 10351 KIAA0308 protein 26 68
433193 AB040881 Hs 32580 Homo sapiens cDNA FLJ13122 fis, clone NT 26 32
445439 BE243084 Hs 12719 regulator of nonsense transcripts 1 26 39
450309 W61348 Hs 4864 KIAA0892 protein 2.6 38
422092 AB007883 Hs 111373 KIAA0423 protein 26 23
424118 BE269041 Hs 140452 cargo selection protein (mannose 6 phosp 26 55
407618 AW054922 Hs 53478 Homo sapiens cDNA FLJ12366 fis, clone MA 26 29
446493 AK001389 Hs 15144 hypothedcal protein DKFZp564O043 26 32
442878 AI868648 Hs 22315 ESTs 26 47
448771 BE315511 Hs 296244 SNARE protein 26 50
416611 AA568308 Hs 192789 ESTs, Weakly similar to ALU7.HUMAN ALU S 26 77
409348 AI401535 Hs 146090 ESTs 26 35
439349 AI660898 Hs 195602 ESTs 26 32
428433 AA521410 Hs 41371 ESTs 26 79
436565 BE547674 Hs 204169 ESTs 26 30
438662 AA223599 Hs 6351 cleavage and polyadenylation specific fa 26 26
429362 T25833 Hs 200478 ubiquidn-conjugatmg enzyme E2M (homolo 26 23
459035 AW291109 Hs 208787 ESTs 26 26
451814 AA847992 Hs 137003 ESTs 26 19 1
452331 AA598509 Hs 29117 H sapiens mRNA for pur alpha extended 3" 26 22
438461 AW075485 Hs 286049 phosphoseπne aminotransferase 26 21
424362 AL137646 Hs 146001 Homo sapiens mRNA cDNA DKFZp586F0824 (f 26 49
423699 H41850 Hs 131846 PCAF associated factor 65 alpha 26 37
441226 BE563042 Hs 118820 ESTs 26 25
444940 AK002148 Hs 12151 hypothetical protein FLJ 11286 26 34
448731 AI522273 Hs 42640 ESTs 26 32
424250 AF073310 Hs 143648 insulin receptor substrate 2 26 25
433468 AA832055 Hs 232217 ESTs, Weakly similar to ALU1.HUMAN ALU S 26 33
419925 AA159850 Hs 93765 lipoma HMGIC fusion partner 26 46
441364 AW450466 Hs 126830 ESTs 26 26
425922 AL157466 Hs 162751 Homo sapiens mRNA, cDNA DKFZp761E2423 (f 25 27
434974 AA778711 Hs 4310 eukaryotic translation initiation factor 25 25 408392 U28831 Hs 44566 KIAA1641 protein 25 254
432426 AW973152 Hs 31050 ESTs 25 100
436623 A1417073 Hs 107265 ESTs 25 21
452683 AI089575 Hs 9071 progesterone membrane binding protein 25 26
410582 AW867197 Hs 14562 Homo sapiens cDNA FLJ21616 fis, clone C 25 37
441328 AI982794 Hs 159473 ESTs 25 92
453983 H94997 Hs 16450 ESTs 25 261
438826 R26709 Hs 10095 hypothedcal protein from EUROIMAGE 1669 25 23
427899 AA829286 Hs 181062 serum amyloid A1 25 203
427820 BE222494 Hs 180919 inhibitor of DNA binding 2, dominant neg 25 35
458933 AI638429 Hs 24763 RAN binding protein 1 25 35
444871 U46386 Hs 12102 sorting nexin 3 25 23
411329 AL360265 Hs 69554 hypothedcal protein FU20552 25 29
424074 AI902456 Hs 210761 ESTs 25 40
438988 H30039 Hs 107674 ESTs 25 27
412836 AA121384 Hs 191446 ESTs 25 57
430189 AI298841 Hs 135133 ESTs, Weakly similar to ORF YNL310C (S c 25 30
432841 M93425 Hs 62 protein tyrosine phosphatase, non recept 25 134
416926 H03109 Hs 108920 HT018 protein 25 28
451429 AA525993 Hs 173699 ESTs, Weakly similar to ALU1 HUMAN ALU S 25 39
416388 A1417358 Hs 73677 ESTs 25 42
421561 Z45399 Hs 105779 protein inhibitor of acdvated STAT prot 25 75
436480 AJ271643 Hs 87469 putadve acid-sensing ion channel 25 26
416273 AW575691 Hs 79123 KIAA0084 protein 25 26
427149 H94688 Hs 173737 ras-related C3 botulinum toxin substrate 25 26
453041 AI680737 Hs 289068 transcπptioπ factor 4 25 22
446899 NM 005397 Hs 16426 podocalyxin like 25 47
447301 AW958124 Hs 142442 HP1-BP74 25 32
447769 AW873704 Hs 48764 ESTs 25 24
447754 AW073310 Hs 163533 Homo sapiens cDNA FU14142 fis, clone MA 25 25
427087 BE073913 Hs 173515 uncharacteπzed hypothalamus protein HT0 25 236
440903 AI468079 Hs 126623 ESTs 25 23
432353 NM 016558 Hs 274411 SCAN domain-containing 1 25 41
408196 AL034548 Hs 43627 SRY (sex determining region Y) box 22 25 25
411373 BE326276 Hs 8861 ESTs 25 39
452402 AI138530 Hs 22216 peroxisome proliferative activated recep 25 24
429998 AI458063 Hs 57841 ESTs 25 26
421772 Z24958 Hs 108139 zinc finger protein 212 25 37
442573 H93366 Hs7567 Homo sapiens cDNA FLJ21962 fis, clone H 25 21
444677 AU 10212 Hs 9242 puπne rich element binding protein B 25 34
441887 AW967865 Hs 92145 ESTs 25 33
451031 AI360187 Hs 4254 ESTs 25 48
432450 AI990739 Hs 77868 ORF 25 24
415860 D56051 Hs 78888 diazepam binding inhibitor (GABA recepto 25 48
439630 AA313607 Hs 58633 Homo sapiens cDNA FLJ22145 fis, clone H 24 23
428607 AB002353 Hs 186840 KIAA0355 gene product 24 40
415402 AA164687 Hs 297889 ESTs 24 25
446888 AL030996 Hs 16411 hypothetical protein LOC57187 24 22
439208 AK000299 Hs 180952 dynacdn p62 subunit 24 24
452900 AA626794 Hs 250655 prothymostn, alpha (gene sequence 28) 24 34
408657 AA782601 Hs 173328 protein phosphatase 2, regulatory subuni 24 36
439143 AI359214 Hs 179260 ESTs 24 25
439867 AA847510 Hs 161292 ESTs 24 93
408138 AA535740 Hs 301967 Homo sapiens mRNA, cDNA DKFZp434M196 (fr 24 56
428386 R17298 Hs 295923 seven in absentia (Drosophila) homolog 1 24 42
417289 D86962 Hs 81875 growth factor receptor-bound protein 10 24 22
405268 24 31
439734 AC005013 Hs 149 cAMP response element-binding protein CR 24 36
445378 AV653564 Hs 226946 ESTs 24 24
454085 D82418 Hs 29626 ESTs, Weakly similar to unknown [D elan 24 220
427354 T57896 Hs 191095 ESTs 24 36
452906 BE207039 Hs 75621 senne (or cysteme) proteinase mhibito 24 22
450065 AL050107 Hs 301558 DKFZP586I1419 protein 24 36
451091 AA810932 Hs 131899 ESTs, Weakly similar to coded for by C 24 27
414839 X63692 Hs 77462 DNA (cytosιne-5-) methyltransferase 1 24 26
420303 AA258282 Hs 278436 KIAA1474 protein 24 20
437068 AA743643 Hs 291427 ESTs 24 26
417446 AL118671 Hs 82163 monoamine oxidase B 24 44
421454 AI660389 Hs 286108 choπomc somatomammotrapiπ hormone 1 (p 24 35
434943 AI929819 Hs 320 xeroderma pig entosum, complementation g 24 64
446342 BE298665 Hs 14846 Homo sapiens mRNA, cDNA DKFZp564D016 (fr 24 30
452847 AK000857 Hs 30783 hypothedcal protein FU20850 24 21
422506 R20909 Hs 117816 sorcm 24 22
405204 24 43
419441 AW023731 Hs 274368 Homo sapiens mRNA, cDNA DKFZp586H524 (f 24 11 7
442293 AW292634 Hs 150358 ESTs 24 21
451484 AV648896 Hs 26461 hypothetical protein 24 20
438545 AB032977 Hs 6298 KIAA1151 protein 24 21
442724 AA355525 Hs 159604 cystemyl tRNA synthetase 24 28
405517 24 66
413822 R08950 Hs 272044 ESTs, Weakly similar to ALU1.HUMAN ALU S 24 38
445679 AI343868 Hs 58800 Homo sapiens cDNA FU12488 fis, clone NT 24 23
408636 BE294925 Hs 46680 CGI-12 protein 24 81 409142 AL136877 Hs 50758 chromosome-associated polypeptide C 24 24
422043 AL133649 Hs 110953 Homo sapiens mRNA, cDNA DKFZp434A139 (fr 24 21
424687 J05070 Hs 151738 malπx metalloprotemase 9 (geladnase 8 24 26
442560 AA365042 Hs 228598 ESTs 24 49
418126 T91451 Hs 86538 ESTs 24 11 7
413313 NM.002047 Hs 75280 glycyl tRNA synthetase 24 21
415167 AA160784 Hs 26410 ESTs 24 44
440040 BE219431 Hs 300713 ESTs 24 34
443595 AF169312 Hs 9613 PPAR(gamma) angiopoietin related protein 24 107
438977 AA482026 Hs 298625 ESTs 24 28
452066 AA772149 Hs 16979 ESTs 24 54
428500 A1815395 Hs 184641 delta-6 fatty acid desaturase 24 22
408503 AW119059 Hs 63163 ESTs, Weakly similar to UDP-GalNAc polyp 24 27
433401 AF039698 Hs 284217 serologically defined colon cancer antig 24 48
412676 NM 00165 Hs 74471 gapjuncdon protein, alpha 1, 43kD (con 24 22
453753 BE252983 Hs 35086 ubiquitin specific protease 1 24 28
424050 AA211218 Hs 138381 famesyltransferase, CAAX box, alpha 24 39
440225 BE295782 Hs 159 tumor necrosis factor receptor superfami 24 767
430512 AF182294 Hs 241578 U6 snRNA-associated Sm-like protein LSm8 24 123
415156 X84908 Hs 78060 phosphoiylase kinase, beta 24 104
435975 AU 18990 Hs 41997 alpha-1-B glycoprotein 24 77
429831 AA564489 Hs 137526 ESTs 24 41
407373 AA031576 Hs 143812 Homo sapiens cDNA FU12956 fis, clone NT 24 33
422221 AA306649 gb EST177656 Jurkat T-cells VI Homo sapi 24 38
451351 AW058261 Hs 168213 ESTs, Weakly similar to ALU1.HUMAN ALU S 24 33
410082 AA081594 Hs 158311 Musashi (Drosophila) homolog 1 24 25
430304 AL122071 Hs 238927 Homo sapiens mRNA, cDNA DKFZp434H1235 (f 24 65
418863 AL135743 Hs 25566 ESTs 24 52
448414 BE391820 Hs 21145 Homo sapiens cDNA FU22489 fis, clone H 24 37
428351 AK001701 Hs 183779 Homo sapiens cDNA FU10590 fis, clone NT 24 62
425750 AL050276 Hs 159456 zinc finger protein 288 24 51
426295 AW367283 Hs 75839 zinc finger protein 6 (CMPX1) 24 1136
408772 W88532 Hs 254562 ESTs 24 123
426307 F24978 Hs 294084 ESTs 24 40
405203 24 25
453537 AA036755 Hs 283681 ESTs 24 36
431427 AK000401 Hs 252748 Homo sapiens cDNA FLJ20394 fis, clone KA 24 62
458021 A1885190 Hs 156089 ESTs, Weakly similar to Kl AA1339 protein 24 43
453928 BE222198 Hs 143851 ESTs 24 26
446853 AV660630 Hs 87627 disrupter of silencing 10 23 97
441626 AA281167 Hs 111911 ESTs 23 230
446138 AW504182 Hs 13999 KIAA0700 protein 23 22
452568 AA805634 Hs 3337 transmembrane 4 superfamily member 1 23 222
417665 AW852858 Hs 22862 ESTs 23 80
420088 AC006486 Hs 298033 Homo sapiens cDNA FU22286 fis, clone H 23 51
421456 AW579842 Hs 104557 hypothetical protein FLJ 10697 23 25
412093 BE242691 Hs 14947 ESTs 23 31 4
428172 U09367 Hs 182828 zinc finger protein 136 (clone pHZ-20) 23 49
450447 AF212223 Hs 25010 hypothedcal protein P15-2 23 23
436001 AW903849 Hs 173840 HUEL(C4orf1)-ιnteraodng protein 23 41
414786 AI246482 Hs 249989 ESTs 23 2 1
459284 AF155660 Hs 34401 mitochondrial solute earner 23 29
452701 NM.00511C I Hs 30332 glutamiπe-fructose 6-phosphate transamm 23 26
446320 AF126245 Hs 14791 acyl Coenzyme A dehydrogenase family, me 23 39
446669 AW972832 Hs 29468 ESTs 23 38
434616 D79338 Hs 239720 CCR4-NOT traπscπpdon complex, subunit 23 36
452135 AI492175 Hs 301805 ESTs 23 23
408696 AW958157 Hs 16542 ESTs 23 28
436176 AL121422 Hs 184013 ESTs, Highly similar to unnamed protein 23 32
419713 AW968058 Hs 92381 nudix (nucleoside diphosphate linked moi 23 170
414197 W44877 Hs 55501 ESTs 23 11 8
445270 AI762154 Hs 54982 Homo sapiens cDNA FU14014 fis, clone HE 23 42
412247 AF022375 Hs 73793 vascular endothelial growth factor 23 5 1
426494 AU 19528 Hs 170098 KIAA0372 gene product 23 44
405687 23 22
417410 AF063020 Hs 82110 PC4 and SFRS1 interacting protein 1 23 20
450747 AI064821 Hs 48306 ESTs, Highly similar to EWS HUMAN RNA-BI 23 38
433680 AI805366 Hs 199945 ESTs 23 67
420025 AF184939 Hs 94392 LDL induced EC protein 23 24
413407 AI356293 Hs 75339 inositol polyphosphate phosphatase like 23 31
452908 AB001451 Hs 30965 neuronal She adaptor homolog 23 30
424414 AI361002 Hs 94814 Homo sapiens cDNA FU12168 fis, clone MA 23 20
435791 AA243086 Hs 25204 chondroitin 4-0 sulfotransferase 2 23 24
457635 AV660976 Hs 3569 hypothedcal protein 23 69
427985 AI770170 Hs 65583 ESTs 23 23
445498 AV654019 Hs 180402 Homo sapiens cDNA FLJ23506 fis, clone L 23 23
410310 J02931 Hs 62192 coagulation factor III (thromboplasdn, 23 41
450368 AU077158 Hs 24930 tubulin-specifio chaperoπe a 23 35
444614 R44284 Hs 2730 heterogeneous nuclear πbonucleoprotein 23 26
448607 AL042506 Hs 21599 Homo sapiens cDNA FU10107 fis, clone HE 23 28
447975 8E378418 Hs 127240 ESTs 23 22
429767 AW793022 Hs 218329 hypothedcal protein 23 11 5
408877 AA479033 Hs 130315 ESTs 23 23 448481 W15284 Hs 74832 ESTs 23 33
452833 BE559681 Hs 30736 KIAA0124 protein 23 28
421057 T58283 Hs 42679 ESTs 23 11 0
408885 C02741 Hs 8712 hypothetical protein FLJ20736 23 46
427615 BE410107 Hs 179817 CGI-82 protein 23 23
448861 AL049951 Hs 22370 Homo sapiens mRNA, cDNA DKFZp564O0122 (f 23 63
430154 AW583058 Hs 234726 serine (or cysteine) proteinase inhibito 23 346
428494 AA233439 Hs 184634 hypothetical protein FU20005 23 102
422987 AW407887 Hs 301772 seπne/threonme kinase 11 (Peutz Jegher 23 32
408216 AA741038 Hs 6670 ESTs 23 33
407862 BE548267 Hs 50724 Homo sapiens cDNA FU10934 fis, clone OV 23 57
432215 AU076609 Hs 2934 πbonucleodde reductase M1 polypepdde 23 2 1
410086 AI268405 Hs 13467 Homo sapiens BAC clone RP11-121 A8 from 7 23 22
444853 AW576245 Hs 149740 Homo sapiens mRNA for FU00028 protein, 23 45
413284 AU077055 Hs 289107 baculoviral IAP repeat-containing 2 23 48
445547 D86181 Hs 273 galactosylceramidase (Krabbe disease) 23 25
420258 AA477514 Hs 96247 translm-associated factor X 23 35
437223 C15105 Hs 107884 ESTs 23 27
437353 AA749195 Hs 143746 ESTs 23 26
426224 BE085860 Hs 168075 karyopheπn (importiπ) beta 2 23 361
402575 Z23024 Hs 138860 Rho GTPase activating protein 1 2.3 31
430712 AW044647 Hs 196284 ESTs 23 24
452036 NM 003966 Hs 27621 sema domain, seven thrombospondm repeat 23 24
425180 U00115 Hs 155024 B-cell CLUymphoma 6 (zinc finger prote 23 43
441648 H05734 Hs 30559 ESTs 23 2 1
424130 AL050136 Hs 140945 Homo sapiens mRNA, cDNA DKFZp586L141 (fr 23 29
414682 AL021154 Hs 76884 inhibitor of DNA binding 3, dominant neg 23 122
423814 AF105020 Hs 132989 putative protein O-maπnosyltransferase 23 37
421641 AI638184 Hs 106334 Homo sapiens clone 23836 mRNA sequence 23 23
427882 AA640987 Hs 193767 ESTs 23 102
442159 AW163390 Hs 8123 chromobox homolog 3 (Drosophila HP1 gamm 23 44
412541 BE009398 Hs 74002 nuclear receptor coacdvator 1 23 24
447217 BE465754 Hs 17778 neuropilin 2 23 30
452336 AA960961 Hs 29147 hypothetical protein FU11015 23 41
423913 NM.016436 Hs 301055 hepatocellular carcinoma-associated and 23 34
411737 AW160339 Hs 71791 hypothetical protein 22 20
412276 BE262621 Hs 73798 macrophage migration inhibitory factor ( 22 24
456974 M12529 Hs 169401 apolipoprotein E 22 26
416033 NM 012201 Hs 78979 Golgi apparatus protein 1 22 104
406739 AI566709 Hs 182426 πbosomal protein S2 22 1153
448646 AU077149 Hs 21704 transcnp oπ factor 1 (HTF4, helix-loo 22 42
437371 AK000868 Hs 5570 hypothetical protein FLJ10006 22 36
451413 AA448974 Hs 26367 PC3-96 protein 22 62
408665 T88845 Hs 112200 ESTs, Weakly similar to ALU7.HUMAN ALU S 22 32
437548 AI701596 Hs 121592 ESTs 22 30
452053 AI750575 Hs 173933 nuclear factor l/A 22 33
428303 AW974476 Hs 183601 regulator of G-proteiπ signalling 16 22 34
441376 H94227 Hs 6592 ESTs, Weakly similar to salivary proline 22 25
413399 BE091833 gb IL2-BT0731-260400 076-F04 BT0731 Homo 22 21
448913 AA194422 Hs 22564 myosin VI 22 24
439053 BE244588 Hs 6456 chaperonin containing TCP1, subunit 2 (b 22 31
428065 AI634046 Hs 157313 ESTs 22 35
425846 AA102174 Hs 159629 myosin IXB 22 71
426404 AA377607 Hs 273138 ESTs 22 33
423464 NM 016240 i Hs 128856 CSR1 protein 22 2 1
436135 D85390 Hs 5057 carboxypeptidase D 22 91
450476 AL045285 Hs 246849 ESTs, Moderately similar to ALU6.HUMAN A 22 25
420798 W93774 Hs 99936 keratin 10 (epidermolydc hyperkeratosis 22 28
433530 BE349534 Hs 281789 ESTs 22 21
436297 AI084582 Hs 5105 hypothedcal protein FU10569 22 24
433058 H86865 Hs 280666 Homo sapiens chromosome 19, cosmid R3218 22 23
435924 AW029203 Hs 191952 ESTs 22 32
417125 AW181998 Hs 81248 CUG triplet repeat RNA binding protein 22 23
449338 H73444 Hs394 adrenomedulliπ 22 183
446065 AA085191 Hs 6949 ESTs, Weakly similar to T2D3.HUMAN TRANS 22 31
410668 BE379794 Hs 65403 hypothetical protein 22 25
424992 AW290893 Hs 96918 Homo sapiens cDNA FU21561 fis, clone C 22 108
437801 AA613866 Hs 5848 Homo sapiens mRNA, cDNA DKFZp564L222 (fr 22 2.5
412491 W31589 Hs 73957 RAB5A, member RAS oncogene family 22 24
446392 AF142419 Hs 15020 homolog of mouse quaking OKI (KH domain 22 34
450503 R35917 Hs 25042 Homo sapiens mRNA full length insert cDN 22 28
432476 T94344 gb ye31h10 s1 Stratagene lung (937210) H 22 26
424251 AA677466 Hs 143696 coacdvator-associated arginine ethyltr 22 50
456619 AV647917 Hs 107153 inhibitor of growth family, member 1-lιk 22 26
433411 AI658666 Hs 49994 ESTs 22 21
424714 AH 14630 Hs 208334 Homo sapiens cDNA FLJ21874 fis, clone H 22 27
416326 AF186780 Hs 79219 RalGDS like gene, KIAA0959 protein 22 22
407696 AI697340 Hs 76549 ATPase, Na+/K+ transporting, alpha 1 pol 22 65
445939 BE018658 Hs 141003 Homo sapiens cDNA. FLJ21691 fis, clone C 22 44
414765 X07854 Hs 77269 guanine nucleotide binding protein (G pr 22 62
407136 T64896 Hs 287420 Homo sapiens cDNA FLJ 11533 fis clone HE 22 28
453665 AA626250 Hs 181165 eukaryodc translation elongation factor 22 23
433608 AW340005 Hs 164485 ESTs 22 2 1 447646 BE619752 Hs 66053 ESTs, Weakly similar to S22126 finger pr 22 41
433139 AB029826 Hs 47649 3-methylcrotoπyl-CoA carboxylase biodn 22 11 7
413433 NM 003199 Hs 289068 transcπption factor 4 22 22
421535 AB002359 Hs 105478 phosphonbosylformylglycinamidine syntha 22 22
428591 BE313029 Hs 185807 Homo sapiens clone 24758 mRNA sequence 22 48
417248 AA329449 Hs 247302 twisted gaslruladon 22 25
403966 22 52
437112 AA744692 Hs 166539 ESTs 22 30
414799 AI752416 Hs 77326 insulin like growth factor binding prote 22 49
431049 AA846576 Hs 103267 hypothetical protein FU22548 similar to 22 44
422100 AI096988 Hs 111554 ADP-πbosyladon factor like 7 22 25
426543 AV650198 Hs 170311 heterogeneous nuclear πbonucleoprotein 22 24
423720 AL044191 Hs 23388 Homo sapiens cDNA FU21310 fis, clone C 22 42
443804 AU 35352 Hs 255883 ESTs 22 22
435080 AI831760 Hs 155111 ESTs 22 25
452808 AF244135 Hs 30670 hepatocellular carcinoma-associated and 22 71
433934 AW273261 Hs 216292 ESTs 22 21
432004 BE018302 Hs 2894 placental growth factor, vascular endoth 22 44
452518 AA280722 Hs 24758 ESTs 22 30
409600 AJ011679 Hs 55099 Homo sapiens mRNA, cDNA DKFZp586D2123 (f 22 23
448965 AF092134 Hs 22679 CGI-24 protein 22 40
444954 AW247076 Hs 12163 eukaryodc translation initiation factor 22 53
458894 AW292171 Hs 23978 scaffold attachment factor B 22 25
402269 22 22
423798 AF047033 Hs 301617 Homo sapiens mRNA full length insert cDN 22 40
413836 W92003 Hs 70614 ESTs 22 36
432231 AA339977 Hs 274127 CLST 11240 protein 2 1 2 1
412204 AI125507 Hs 130829 ESTs 2 1 30
438807 AA848011 Hs 124570 ESTs, Weakly similar to reverse transcπ 2 1 22
404170 21 41 6
434858 AW979012 Hs 134462 ESTs 21 22
426982 AA149707 Hs 173091 ubiquitin like 3 21 21
421939 BE169531 Hs 109727 TAK1-bmdmg protein 2, KIAA0733 protein 21 265
442432 BE093589 Hs 38178 Homo sapiens cDNA FLJ23468 fis, clone H 2 1 37
424950 AA602917 Hs 156974 ESTs 21 199
418123 AA669830 Hs 83530 hypothedcal protein 21 46
440467 AK001519 Hs 7194 CGI-74 protein 21 53
437092 AA744292 Hs 181244 major histocompadbility complex, class 2 1 30
421579 NM 002975 Hs 105927 stem cell growth factor; lymphocyte seer 21 33
428953 AA306610 Hs 194676 DKFZP434C013 protein 21 50
457313 AF047002 Hs 241520 transcriptional coactivator 2 1 35
420570 AI453665 Hs 290870 ESTs, Weakly similar to S23650 retroviru 2 1 2 1
446918 AL135125 Hs 13913 KIAA1577 protein 2 1 23
427567 N24236 Hs 179662 nucleosome assembly protein 1-lιke 1 21 28
446363 AU 17440 Hs 301967 Homo sapiens mRNA, cDNA DKFZp434M196 (fr 21 40
428482 AI290352 Hs 184592 KIAA0344 gene product 21 28
456559 AI336273 Hs 102548 glucocorticoid receptor DNA binding fact 2 1 23
442819 BE622721 Hs 301766 ESTs, Weakly similar to hypothedcal pro 2 1 27 1
428808 AA436007 Hs 188780 ESTs 2 1 50
414893 AA215295 Hs 77578 ubiquitin specific protease 9, X chromos 21 159
447023 AA356764 Hs 17109 integral membrane protein 2A 21 30
402250 AV655272 Hs 20252 novel Ras family protein 2 1 42
429952 AF080158 Hs 226573 inhibitor of kappa light polypeptide gen 2 1 79
420006 H14429 Hs 94300 serologically defined colon cancer andg 2 1 56
407316 AA031663 Hs 28802 centaunn alpha 2 protein 2 1 44
417139 M69043 Hs 81328 nuclear factor of kappa light polypeptid 21 1032
414774 X02419 Hs 77274 plasminogen activator, urokmase 21 299
430488 D19589 Hs 4220 ESTs, Moderately similar to tetraeycline 21 21
428680 U69199 Hs 90259 ESTs, Weakly similar to alpha 1 [H sapie 21 25
448501 AA332316 Hs 4273 hypothetical protein FU13159 21 20
422552 N39729 Hs 118243 deoxyπbonuclease II, lysosomal 21 29
419476 AW953030 Hs 59425 Homo sapiens cDNA FLJ23323 fis clone H 21 31
408681 AW953853 Hs 292833 ESTs 21 39
417353 AA375752 Hs 76362 general tranεcπption factor HA, 2 (12k 21 4 1
422070 AF149785 Hs 111126 pituitary tumor-transforming 1 interact! 2 1 49
442711 AF151073 Hs 8645 hypothetical protein 2 1 22
450139 AK001838 Hs 296323 Homo sapiens cDNA FU10976 fis, clone PL 21 74
452897 BE066058 Hs 269233 ESTs 21 42
409147 AI889208 Hs 17283 hypothetical protein FLJ 10890 2 1 45
433028 AI199144 Hs 283737 AD-017 protein 2 1 26
407831 BE613377 Hs 15580 Homo sapiens cDNA FU22276 fis, clone H 21 85
417871 AA521368 Hs 24252 ESTs 21 29
428754 AI521102 Hs 301374 ESTs, Moderately similar to ALU5.HUMAN A 21 53
430127 AA219498 Hs 233952 proteasome (prosome, macropain) subunit, 21 43
442622 NM 00043J i Hs 8546 Notch (Drosophila) homolog 3 2 1 85
414242 AA749230 Hs 22666 ESTs 21 28
433323 AA805132 Hs 30701 ESTs 21 50
439022 AA356599 Hs 173904 ESTs 21 64
443357 AW016773 Hs 75615 apolipoprotein C-ll 21 20
449103 T24968 Hs 23038 HSPC071 protein 2 1 27
427512 AB018322 Hs 179507 KIAA0779 protein 21 20
426728 NM 007118 Hs 171957 tπple functional domain (PTPRF interact 21 29
440112 AA099014 Hs 231029 ESTs 21 23 446920 BE397649 Hs 31257 Homo sapiens cDNA FLJ13634 fis, clone PL 2 1 48
428459 D44650 Hs 184411 gene with multiple splice vanants near 21 29
432842 AW674093 Hs 279525 hypothetical protein PRO2605 2 1 23
438829 AA826926 Hs 204214 ESTs 21 27
411442 N25956 Hs 101810 Homo sapiens cDNA FU14232 fis, clone NT 21 22
409423 AI969783 Hs 43071 ESTs, Weakly similar to AF151900 1 CGI-1 21 22
456804 AI421645 Hs 139851 caveol 2 21 15 2
434536 H14486 Hs 3903 Cdc42 effector protein 4, binder of Rho 21 28
447126 AW150632 Hs 62954 ferπdn, heavy polypepdde 1 21 250
442328 AI952430 Hs 265237 ESTs 2 1 21
444488 AW192879 Hs 184796 ESTs, Weakly similar to PET2.HUMAN OLIGO 21 29
438874 H02780 gb yj41a11 r1 Soares placenta Nb2HP Homo 2 1 106
412805 AW954569 Hs 296287 ESTs 21 46
446334 U52427 Hs 14839 polymerase (RNA) II (DNA directed) polyp 21 23
427201 AB037860 Hs 173933 nuclear factor l/A 21 5 1
436997 AA741151 Hs 137323 ESTs 21 30
426369 AF134157 Hs 169487 Kreisler (mouse) maf-related leucine zip 21 23
453613 F06838 Hs 14763 ESTs 21 24
413276 Z24725 Hs 75260 mitogen inducible 2 21 55
422050 AA302741 Hs 25786 ESTs 21 40
424797 AA622394 Hs 153177 nbosomal protein S28 21 2 1
437365 AW965771 Hs 91065 hypothetical protein DKFZp761B2423 21 30
412482 AI499930 Hs 181043 KIAA0788 protein 21 27
418662 AI801098 Hs 151500 ESTs 2 1 21
404030 21 21
437802 AI475995 Hs 122910 ESTs 21 38
441130 AI160734 Hs 283429 SMC (mouse) homolog, X chromosome 21 35
416084 L16991 Hs 79006 deoxythymidylate kinase (thymidylate km 21 74
409944 8E297925 Hs 57687 four and a half LIM domains 3 21 63
425421 L11669 Hs 157145 tetracycliπe transporter-like protein 2 1 7 1
428399 NM 006276 Hs 184167 splicing factor, argmine/seππe-πch 7 2 1 27
421313 NM 014923 Hs 103329 KIAA0970 protein 2 1 26
445229 BE276013 Hs 172364 Homo sapiens mRNA for FU00086 protein, 21 47
401001 21 147
425159 NM 004341 Hs 154868 carbamoyl-phosphate synthetase 2, aspart 21 72
438855 AW946276 Hs 6441 dssue inhibitor of metalloprotemase 2 21 49
433369 Z49254 Hs 3254 mitochondπal nbosomal protein L23 21 250
433228 F28212 Hs 284247 KIAA1491 protein 21 5 1
445392 AA057478 Hs 23272 ESTs 20 23
433891 AA613792 gb no97h03 s1 NCI CGAP Pr2 Homo sapiens 20 25
432572 AI660840 Hs 191202 ESTs, Weakly similar to ALUE HUMAN "" 20 29
448474 AI792014 Hs 13809 ESTs 20 12 1
427045 H86504 Hs 173328 protein phosphatase 2, regulatory subuni 20 29
444916 AB028956 Hs 12144 KIAA1033 protein 20 42
439177 AW820275 Hs 76611 ESTs 20 33
423533 NM 014339 Hs 129751 interieukin 17 receptor 20 50
430057 AW450303 Hs 2534 bone morphogenedc protein receptor, typ 20 Z3
424429 U63830 Hs 146847 TRAF family member-associated NFKB acdv 20 127
428385 AF112213 Hs 184062 putadve Rab5-ιnteracdng protein 20 46
458946 AA009716 Hs 42311 ESTs 20 164
444816 Z48633 Hs 283742 H sapiens mRNA for retrotransposon 20 49
426829 AI761241 Hs 301719 ESTs 20 24
433619 AW965275 Hs 284288 hqp0256 protein 20 44
421985 AK001779 Hs 110445 CGI-97 protein 20 38
439895 AB037773 Hs 6762 hypothetical protein FU10595 20 22
449188 AW072939 Hs 23200 myotubulaπn related protein 1 20 22
404820 20 27
425811 AL039104 Hs 159557 karyopheπn alpha 2 (RAG cohort 1 , impor 20 25
422163 AF027208 Hs 297332 Homo sapiens cDNA FU21471 fis, clone C 2.0 37
431172 AH 25639 Hs 250666 hairy (Drosophila) homolog 20 102
415200 AL040328 Hs 301912 Homo sapiens cDNA FLJ22920 fis, clone K 20 21
458176 AI961519 Hs 140309 ESTs, Weakly similar to KIAA0681 protein 20 50
407895 R44203 Hs 265540 HSPC042 protein 20 46
449816 AI701457 Hs 38694 ESTs 20 20
422976 AU076657 Hs 1600 sec61 homolog 20 57
430220 BE378277 Hs 152230 ESTs 20 11 7
435446 AA682305 Hs 133268 ESTs 20 42
431031 AA830335 Hs 105273 ESTs 20 141
425233 Z17861 Hs 155218 E1B-55kDa-assocιated protein 5 20 56
426458 D83032 Hs 169984 nuclear protein 20 59
421965 AA301100 gb EST14128 Testis tumor Homo sapiens cD 20 21
427128 AW301984 Hs 173685 Homo sapiens cDNA FU12619 fis, clone NT 20 63
449722 BE280074 Hs 23960 cyclm B1 20 21
450816 BE271927 Hs 87385 ESTs 20 24
453507 AF083217 Hs 33085 WD repeat domain 3 20 131
422801 AF125672 Hs 287994 nuclear receptor co-repressor 2 20 35
418178 AA043951 Hs 83715 Sjogren syndrome antigen B (autoandgen 20 39
417819 AI253112 Hs 133540 ESTs 20 40
414787 AL049332 Hs 77311 BTG family, member 3 20 40
447032 AK000310 Hs 17138 hypothetical protein FU20303 20 70
431742 NMJ.1665; ! Hs 268281 CGI-201 protein 20 25
448431 BE613061 Hs 300697 ESTs, Weakly similar to CA13.HUMAN COLLA 20 65
456444 AA884517 Hs 31856 ESTs, Weakly similar to KIAA1453 protein 20 25 419178 NM 006284 Hs 89657 TATA box binding protein (TBP)-assocιate 20 60 446437 AW014360 Hs 202119 ESTs, Weakly similar to A46010 X-lmked 20 22 449910 AI074585 Hs 58440 ESTs 20 2 1 435963 AF271212 Hs 87627 disrupter of silencing 10 20 2 1 421283 AI760018 Hs 205071 ESTs 20 26 414482 S57498 Hs 76252 endothelm receptor type A 20 24 450960 AB013897 Hs 25722 Homo sapiens mRNA for HKR1, partial eds 20 2 1 438644 AI126162 Hs 129037 ESTs 20 21 458343 AI004775 Hs 205091 ESTs, Weakly similar to WW domain biπdm 20 65 412574 BE410731 Hs 74050 follicular lymphoma vanant translocado 20 124 458079 AI796870 Hs 54277 ESTs 20 38 450582 AI339732 Hs 13144 HSPC160 protein 20 28 409936 AK001691 Hs 57655 hypothedcal protein FLJ 10829 20 3 1 426865 D63476 Hs 172813 PAK-interacting exchange factor beta 20 33 446430 AA346837 Hs 15075 hypothedcal protein DKFZp434E2216 20 20
Table 4B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
447197 2176805 1 R36075 R36167 AI366546
407192 2200202.1 AA602964AA609200
429007 327976 1 AA443145 BF958169AW904500AL119015 D80642
429163 1238297 1 AW974271 AA592975 AA447312AA884766
439579 24302 1 AF086400W73990W79232
432060 1235850 1 AA525021 AW971364 AA570759
416913 924456 1 AW934714AW749864AW7499028E162498 BE161005 BE162499 BE161006AA190449AW513465 BE162500 BE161007
426413 372468 1 AW954494AA377823BG219617 BG195685BG616269AI022688
433586 32908 1 BC011194 AW517087 AA601054 T85512
448451 7632 32 AW000978 R39898AW015994AI598202 BF821479AI521706
442495 928718 1 Al 184717 AW518883 AF121173
439566 23928 ϊ AF086387W72711 W77884
407939 600387 1 AW118352 AW196215 W05608
453740 612139 1 AL120295 BG291384 T88779
433854 899720 1 BG675161 H59558 AI699484 AA610649 AI937812
413020 1485885 1 BE048113 R98736Z42904
458050 61684 1 AK057874 AW901381 AW901380 AV730240 T50211 AA828756 AA834708
440769 21430 5 BG419454 BF924037 R13764 AW793200 BE561793 BG698295 BE270077
428832 1137866 1 BI008687 AA481363 AA436432 BI008686 AA578229 AA481375
414473 35761 3 BG392866 BE302693
422343 786037.1 AW961833 AA309282 AA551780 AI628633 AA551995 AW378461
431319 122030 1 BG435498 BG924768 AV718636 AA873350 T82428 T82429 AU185416 AA658442
422221 319 18 BG910399 BE826714 BF905312 AA306649 Z40822 N76633
413399 151Ϊ159 1 BE091833 BE091874 BE091871
432476 1237465 1 AW973269 AA548913 T94344 AA834800 AA857492
438874 52147 1 AF075017 R66779 R22463 H02780
433891 647290 1 AW182329 AA613792 T05304 AW858385
421965 1883 13 BC022394 A1742351 BE676249 AI742341 AW572776 AI566256 AI538553 BI837905 AA301100 AA620903 AI142397 AW082310 AI147387 BF509145
AW968207 AA468415 AU185163 AW450843 AI568752 AW137191
TABLE 4C
Pkey Unique number conesponding to an Eos probeset Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495 Strand Indicates DNA strand from which exons were predicted
N posidon Indicates nucleotide positions of predicted exons Pkey Ref Strand Nt.posidon
400859 9757499 Minus 91888-92018,98131-98294,99474-99570 405238 7249119 Minus 51728-51836
400992 8096828 Plus 140390-140822
400860 9757499 Minus 151830-152104,152649-152744 402524 9798518 Minus 20529-21096
404210 5006246 Plus 169926-170121
402604 9909420 Plus 20393-20767
402855 9662953 Minus 59763-59909
404029 7671252 Plus 108716-111112 402605 9909420 Minus 4768047973
404049 3688074 Minus 75765-78155
403549 8081591 Minus 137150-137362
404048 3688074 Minus 54421-56808
404171 9930793 Plus 173667-173783,176876-177055 405649 4926908 Minus 50032-50132,50624-50764
405268 4156151 Minus 24404-24521
405204 7230116 Plus 126569-126754
405517 9454624 Plus 114757-114877
405203 7230116 Plus 125295-125463 405687 6249668 Minus 54787-54891,55844-55917
403966 8568881 Plus 158193-158277,160116-160290
402269 3128156 Minus 1168-1324,5492-5611,23445-23851
404170 9930793 Plus 168836-169248 404030 7671252 Plus 149362-151749 401001 7229886 Minus 113631-113762 404820 4678240 Plus 20475-21085
TABLE 5A: ABOUT 43 GENES UPREGULATED IN GLIOBLASTOMA THAT ENCODE PREDICTED MEMBRANE PROTEINS
Pkey: Unique Eos probeset identifier number
ExAccn: Exemplar Accession number, Genbank accession number
UnigenelD : Unigene number
Unigene Title: Unigene gene tide
R1: Ratio of brain tumor to body atlas
R2: Ratio of brain tumor to normal brain
Pkey ExAccn UnigenelD Unigene title R1 R2
415817 U88967 Hs.78867 protein tyrosine phosphatase, receptor-t 72.0 11.3
447072 D61594 Hs.17279 tyrosylprotein sulfotransferase 1 54.2 7.1
451099 R52795 Hs.25954 interieukin 13 receptor, alpha 2 22.0 7.6
415910 U20350 Hs.78913 chemokine (C-X3-C) receptor 1 21.2 3.0
412986 X81120 Hs.75110 canπabinoid receptor 1 (brain) 18.6 18.6
417355 D13168 Hs.82002 endothelin receptor type B 16.4 16.4
419721 NM_001650 Hs.288650 aquaporin 4 16.2 4.4
452355 N54926 Hs.29202 G protein-coupled receptor 34 13.9 13.9
410227 AB009284 Hs.61152 exostoses (multiple)-like 2 11.9 2.9
419723 AL120193 Hs.92614 Homo sapiens growth differentiation fact 7.4 3.5
414825 X06370 Hs.77432 epidermal growth factor receptor (avian 6.9 6.4
443898 AW804296 Hs.9950 Sec61 gamma 4.8 7.2
422033 AW245805 Hs.110903 claudin 5 (transmembrane protein deleted 4.3 6.1
414821 M63835 Hs.77424 • Fc fragment of IgG, high affinity la, re 4.2 34.8
431556 AF016028 Hs.260039 sarcospan (Kras oncogene-associated gene 4.0 3.8
435869 AF255910 Hs.54650 vascular endothelial junction-associated 3.7 4.2
440516 S42303 Hs.161 cadherin 2, type 1, N-cadherin (neuronal 3.5 5.1
428141 D50402 Hs.182611 solute carrier family 11 (proton-coupled 3.5 2.4
428484 AF104032 Hs.184601 solute carrier family 7 (cationic amino 3.4 2.8
431053 S40369 Hs.249141 Glutamate receptor subunit 3.3 2.4
445070 NM 000677 Hs.258 adenosine A3 receptor 3.2 7.6
430890 X54232 Hs.2699 glypican 1 3.2 4.3
423422 AC005175 Hs.128425 NY-REN-24 antigen 3.2 4.0
413367 NM 006517 Hs.75317 solute earner family 16 (monocarboxylic 3.1 2.6
447471 AF039843 Hs.18676 sprouty (Drosophila) homolog 2 3.0 4.1
427150 BE616183 Hs.173737 ras-related C3 botulinum toxin substrate 3.0 4.1
422676 D28481 Hs.1570 histamine receptor H1 3.0 2.1
430293 AI416988 Hs.238272 inositol 1 ,4, 5-trip hosphate receptor, ty 3.0 6.3
453496 AA442103 Hs.33084 solute carrier family 2 (facilitated glu 2.8 7.4
428281 AA194554 Hs.183434 ATPase, H+ transporting, lysosomal (vacu 2.7 3.2
417446 AU 18671 Hs.82163 monoamine oxidase B 2.4 4.4
412676 NM 000165 Hs.74471 gap junction protein, alpha 1, 43kD (con 2.4 2.2
440225 BE295782 Hs.159 tumor necrosis factor receptor superfami 2.4 76.7
450447 AF212223 Hs.25010 hypothetical protein P15-2 2.3 2.3
410310 J02931 Hs.62192 coagulation factor III (thromboplastin, 2.3 4.1
452036 NM.003966 Hs.27621 sema domain, seven thrombospondin repeat 2.3 2.4
447217 BE465754 Hs.17778 neuropilin 2 2.3 3.0
447023 AA356764 Hs.17109 integral membrane protein 2A 2.1 3.0
422070 AF149785 Hs.111126 pituitary tumor-transforming 1 interacti 2.1 4.9
456804 AI421645 Hs.139851 caveoliπ 2 2.1 15.2
430057 AW450303 Hs.2534 bone morphogenetic protein receptor, typ 2.0 2.3
422163 AF027208 Hs.297332 Homo sapiens cDNA: FU21471 fis, clone C 2.0 3.7
414482 S57498 Hs.76252 endothelin receptor type A 2.0 2.4
TABLE 6A: ABOUT 397 GENES DOWNREGULATED IN GLIOBLASTOMA
Pkey: Unique Eos probeset identifier number
ExAccn: Exemplar Accession number, Genbank accession number
UnigenelD: Unigene number
Unigene Title: Unigene gene title
R1 : Ratio of normal brain to body atlas
R2: Ratio of normal brain to brain tumor
Pkey Ex Accn UnigenelD Title R1 R2
439340 AB032436 Hs.6535 brain-specific Na-dependent inorganic ph 4.47 77.82
424846 AU077324 Hs.1832 πeuropeptide Y 4.49 55.32
428874 W32133 Hs.194366 traπsthyretin (prealbumin, amyloidosis t 7.06 45.64
416836 D54745 Hs.80247 cholecystokinin 9.45 44.59
401412 c14p3_2958 exon 3.20 32.56
451835 T63643 Hs.209715 ESTs, Weakly similar to ALU7.HUMAN ALU S 3.21 28.93
412768 AW996044 Hs.26239 ESTs 3.16 28.12
415448 T68645 Hs.952 solute carrier family 10 (sodium/bile ac 3.27 27.04
411305 BE241596 Hs.69547 myelin basic protein 13.80 25.92
438054 AA776626 Hs.62183 ESTs 3.59 25.06
410837 BE145698 gb:IL0-HT0205-231199-145-a07 HT0205 Homo 3.05 24.43
425121 AI797511 Hs.154679 synaptotagmin 1 6.92 23.67
456763 AJ271351 Hs.128180 B-cell translocation gene 4 3.29 23.32
429656 X05608 Hs.211584 neurofilament, light polypeptide (68kD) 8.03 22.56
451892 AI821302 Hs.167834 ESTs 4.12 21.82 424922 BE386547 Hs 217112 ESTs, Weakly similar to Similaπty to Ye 441 21 28
411666 AF106564 Hs 71346 neurofilament 3 (150kD medium) 5 27 21 20
432247 AA531287 Hs 105805 ESTs 325 21 14
436812 AW298067 gb Ul-H BWO ajp-g 09 0-UI s1 NCI_CGAP.Su 302 21 12
422234 AF119818 Hs 113287 discs, large (Drosophila) homolog associ 338 2050
435708 AI362949 Hs 75169 ESTs 879 2045
423135 N67655 Hs 26411 ESTs 682 2028
440600 AI807691 Hs 126351 ESTs 356 2009
405230 cNpl 7656 exon 331 1995
456915 N55540 Hs 78026 ESTs, Weakly similar to similar to aπkyr 314 1940
425130 AA448208 Hs 99163 ESTs 353 1920
416812 H91010 Hs 44940 ESTs 354 1908
454171 AW854832 gb QV2-CT0261-201099-011-fO5 CT0261 Homo 378 1904
457463 AW877031 Hs 272321 Homo sapiens cDNA FU12571 fis, clone NT 313 1891
454589 AW809699 gb MR4-ST0124-241199-026-e12 ST0124 Homo 4 10 18 60
418104 T05726 Hs 177130 ESTs 317 1841
416357 T82050 Hs 268907 ESTs 311 18 13
414683 S78296 Hs 76888 internexm neuronal intermediate filameπ 555 18 13
447694 AI420083 Hs 170303 ESTs 356 1779
427627 R87582 Hs 179915 guanine nucleotide binding protein (G pr 463 1765
428010 AA806554 Hs 185375 ESTs 303 1740
417159 R01761 gb ye81f10 s1 Soares fetal liver spleen 323 1738
436788 AA766908 Hs 259047 ESTs 316 1721
459349 AW749381 gb QV3-BT0381-170100 060-C02 BT0381 Homo 3 26 17 10
450214 BE439763 Hs 227571 regulator of G-protem signalling 4 386 1704
438068 AI927209 Hs 283089 HMT1 (hnRNP methyltransferase, S cerevi 354 1648
437268 AI754847 Hs 227571 regulator of G-protem signalling 4 563 16 32
435315 AA700240 Hs 165402 ESTs 406 16 12
424240 AB023185 Hs 143535 calcium/calmodulin-dependent protein km 469 1592
412446 AI768015 Hs 92127 ESTs 544 1575
449714 AB033015 Hs 23941 KIAA1189 protein 459 1543
435832 AA425688 Hs 41641 Bruno (Drosophila) -like 4, RNA binding 463 1497
437397 AA349847 Hs 4221 hypothetical protein DKFZp761H039 5 93 1481
435502 L13266 Hs 105 glutamate receptor, lonotropic, N-methyl 329 1461
414187 BE312141 gb 601145962F1 NIH MGC 19 Homo sapiens c 337 1446
417868 AI078534 Hs 122592 ESTs 757 1422
428536 AI143139 Hs 2288 vismin-like 1 516 1398
402125 c18p3 155 exon 3 11 1394
440503 NM 006539 Hs 7235 calcium channel, voltage-dependent gam 349 1392
419090 T85201 Hs 188468 ESTs 325 1379
437665 AA765417 Hs 292053 ESTs 307 1379
457113 AI734016 Hs 270508 ESTs 3 50 1369
424933 AW999974 Hs 5181 proliferation-associated 2G4, 38kD 359 1348
443489 AI073512 Hs 133916 ESTs 324 13 20
404289 c6p3 5821 exon 399 13 12
406534 ph2_4616 exon 3 89 13 10
423280 AA324037 gb EST26901 Cerebellum II Homo sapiens c 3 38 1303
455421 AW937661 Hs 288324 Homo sapiens cDNA FLJ13283 fis clone OV 304 1293
433725 AF063559 Hs 283919 Homo sapiens clone HQ0117 PRO0117 mRNA, 371 12 85
416660 R98905 Hs 35992 ESTs 392 1274
407593 AW044083 Hs 237008 ESTs 3 85 1267
451734 NM 006176 Hs 26944 neurogranin (protein kinase C substrate, 741 1259
410366 AI267589 Hs 25214 hypothetical protein 7 89 1250
405348 cNp3 13716 exon 345 1242
442338 AI761976 Hs 156080 ESTs 369 12 35
424458 M29273 Hs 1780 myelm associated glycoprotein 472 1231
431400 AA504607 gb aa63a02s1 NCI CGAP GCB1 Homo sapiens 342 1229
417754 R13027 Hs 268703 ESTs 335 12 18
440184 AB002297 Hs 7022 dedicator of cyto-kmesis 3 6 15 12 11
431339 AA506294 Hs 257266 ESTs 350 11 97
452265 BE501516 Hs 114772 ESTs 382 11 96
419297 AA446040 Hs 98640 Homo sapiens cDNA FU21069 fis, clone C 3 16 11 86
424991 AA775471 Hs 241467 ESTs 303 11 64
431988 AC002302 Hs 77202 protein kinase C, beta 1 378 11 62
450987 AA017202 Hs 32794 ESTs 328 11 61
440607 AA894559 Hs 192097 ESTs 311 11 60
454566 AW807605 gb MR4-ST0098-120100-001-b06 ST0098 Homo 326 11 54
442000 H38671 Hs 8071 KIAA0735 gene product, synaptic vesicle 344 11 51
437948 AA772920 gb ae73c09 s1 Stratagene schizo brain SI 3 16 11 46
401081 c11p3 921 exon 3 18 11 35
438919 AW979114 gb EST391224 MAGE resequences, MAGP Homo 4 16 11 35
454578 AW809178 gb MR4-ST0118-261099012-c07 ST0118 Hoιτιo 302 11 27
422279 H69644 Hs 114231 C-type lecdn like receptor 2 335 11 13
453101 AW952776 Hs 94943 ESTs 321 11 07
455836 BE145795 gb MR0-HT0208-101299-103-a12 HT0208 Homo 361 1083
413324 V00571 Hs 75294 corticotropin releasing hormone 372 1071
412266 N59006 Hs 26133 ESTs 380 1060
436887 AW953157 Hs 193235 ESTs 724 1056
454968 AW849046 gb IL3-CT0214-150300-085-H06 CT0214 Homo 305 1053
418162 T11958 gb A802R Heart Homo sapiens cDNA clone A 307 1050
425537 AB007913 Hs 158291 KIAA0444 protein 307 1046
436230 AI248723 Hs 17711 ESTs 309 1045
431169 AW971240 gb EST383329 MAGE resequences, MAGL Homo 302 1043 447359 NM 012093 Hs 18268 adenylate kinase 5 591 1040
457187 AA443927 Hs 144360 EST 330 1039
407539 X91103 gb H sapiens mRNA for Hr44 protein 302 1035
452855 R17746 Hs 84469 ESTs 302 1026
440352 AI692322 Hs 65373 ESTs 303 1020
456116 Z28528 Hs 172004 ddn 311 10 17
458172 BE007237 gb PM0-BN0139-050500-003^09 BN0139 Homo 332 10 14
445881 AI263029 Hs 210689 ESTs 304 10 11
454059 NM 003154 Hs 37048 statheπn 327 997
402624 dp1_2660 exon 305 994
441539 AA937200 Hs 192939 ESTs 327 9 82
412172 N76794 gb yv45g07 r1 Soares fetal liver spleen 303 978
427942 AA417856 gb zv01d05 r1 NCI CGAP.GCB1 Homo sapiens 409 973
436867 BE041837 Hs 120316 ESTs 325 973
454688 AW814472 gb MR3-ST02O3-O1020O-109-b06 ST0203 Homo 341 973
446122 AI362790 Hs 181801 ESTs 340 971
420480 AL137361 Hs 98173 hypothetical protein 303 9 56
433447 U29195 Hs 3281 neuronal pentraxin II 372 954
407178 AA195651 Hs 104106 ESTs 389 947
415614 F12926 Hs 165998 DKFZP564M2423 protein 306 945
450518 BE245175 Hs 270893 ESTs 399 939
455675 BE065984 gb RC3-BT0319-120200-014-a06 BT0319 Homo 346 9 32
456459 AA253074 Hs 146261 ESTs 408 930
423420 AI571364 Hs 128382 Homo sapiens mRNA, cDNA DKFZp761l1224 (f 518 923
455644 BE064521 gb RC4-BT0311-250200-014-d02 BT0311 Homo 302 920
419800 AA282392 Hs 191525 ESTs 328 916
430964 Y10929 Hs 248167 zinc finger protein 186 (Kruppel type) 304 900
409716 AL117454 Hs 56027 Homo sapiens mRNA, cDNA DKFZp586J1717 (f 302 900
412962 AW839578 Hs 18160 Homo sapiens cDNA FU11550 fis, clone HE 3 33 899
445040 AW444934 Hs 195929 ESTs, Weakly similar to pre-serum amyloi 350 896
451496 AW503407 gb UI-HF-BNO-akw-d-11-O-UI rl NIH.MGC.50 3 17 8 94
424617 AA344151 gb EST50059 Gall bladder 1 Homo sapiens 325 891
441914 AA971496 Hs 128465 ESTs 342 888
405320 cNp3 12168 exon 330 8 84
449179 AI633785 Hs 196561 ESTs 343 884
400335 Y13187 Hs 248066 Homo sapiens dmd gene, intron 11 3 13 878
454962 AW847645 gb IL3-CT0213-280100-056-A04 CT0213 Homo 416 874
407803 AW081681 Hs 269064 ESTs 309 873
455260 AW878317 gb MR3-OT0007-260300-206-e09 OT0007 Homo 378 870
431096 AA324358 Hs 249227 Homo sapiens DNA, cosmid clones TN62 and 401 8 67
424481 R19453 Hs 1787 proteolipid protein (Pelizaeus-Merzbache 8 12 863
407616 AW054849 Hs 246831 ESTs, Weakly similar to CIKG.HUMAN VOLTA 308 8 53
434589 AF147363 gb Homo sapiens full length insert cDNA 326 8 51
439239 AI031540 Hs 235331 ESTs 578 848
410926 AW810708 gb MR2-ST0129 051099 007-g07 ST0129 Homo 3 34 847
430004 U27768 Hs 227571 regulator of G-protem signalling 4 426 845
409623 AW449185 gb Ul-H BI3-akg-e-05-0 Ul s1 NCI CGAP Su 332 843
420156 AW449258 Hs 6187 ESTs 340 838
411555 AF113537 Hs 70669 HMP19 protein 5 85 834
408509 AA497035 Hs 110502 ESTs 317 8 34
442368 AI698577 Hs 202481 ESTs 302 833
457870 AA732217 Hs 294054 ESTs 304 832
437254 AA831258 gb ∞73f04 s1 NCI.CGAP.GCB1 Homo sapiens 3 35 824
415508 R39236 gb yc91d03 s1 Soares infant brain 1 NIB H 307 8 22
409483 U49379 Hs 54506 diacylglycerol kinase, epsilon (64kD) 331 820
435229 AA676556 Hs 269515 ESTs, Moderately similar to ALUB.HUMAN ι 3 21 819
458120 W21398 Hs 54523 ESTs, Weakly similar to cytochrome P-450 3 22 8 17
444613 H29627 Hs 79092 ESTs 378 8 16
417050 N39540 Hs 108029 ESTs 406 814
425607 U09860 Hs 158333 protease, senne, 7 (enterokmase) 368 806
413263 BE075131 gb PM1-BT0585-110200-003-g03 BT0585 Homo 340 804
424549 AI873205 Hs 183114 Homo sapiens cDNA FLJ14236 fis, clone NT 327 803
452689 F33868 Hs 284176 transfernn 303 801
405476 cNp3_19940 exon 3 28 800
403932 c5p1 533 exon 358 799
407095 AF011757 Hs 105937 F*AGE binding protein 332 796
415967 H11124 gb ym14h07 s1 Soares infant brain 1 NIB H 310 796
417555 H65366 gb yr67c10 r1 Soares fetal liver spleen 305 795
448985 AA324885 Hs 22777 carbonic anhydrase XI 530 779
428689 NM 014351 Hs 189810 sulfotransferase related protein 387 774
424140 Z48051 Hs 141308 myeliπ oligodeπdrocyte glycoprotein 468 774
441099 AW339393 Hs 126573 ESTs 308 774
448589 AF017090 Hs 21554 KIAA1107 protein 3 10 773
406112 phO 24243 exon 322 770
458439 AV647220 Hs 282889 ESTs, Weakly similar to strong similaπt 322 769
429859 NM.007050 Hs 225952 protein tyrosine phosphatase, receptor t 315 768
412090 AW955826 Hs 12396 ESTs, Weakly similar to ALU6.HUMAN ALU S 301 767
413547 BE147440 gb RC1-HT0229 080100-015-109 HT0229 Homo 301 766
447772 AI924558 Hs 161399 ESTs 304 763
411132 AW819191 gb CM1-ST0283-071299-061 d08 ST0283 Homo 372 761
425490 NM 002248 Hs 158173 potassium intermediate/small conductance 315 760
454568 BE141434 gb MR0-HT0079 051099 002-d01 HT0079 Homo 3 16 759
439099 AB037800 Hs 6462 KIAA1379 protein 340 757 415669 NM 005025 Hs 78589 senne (or cysteine) proteinase iπhibito 571 757
428175 AI810774 Hs 98376 ESTs 304 755
413162 BE068115 gb CM1-BT0368 061299 060-g07 BT0368 Homo 343 754
451361 AA053854 Hs 235390 Homo sapiens mRNA, cDNA DKFZp7618101 (fr 3 11 7 53
442527 AF150289 Hs 205436 ESTs 331 753
450407 NM.000810 Hs 24969 gamma-aminobutync acid (GABA) A recepto 524 753
456966 AI589569 Hs 190082 ESTs 3 13 747
441799 AW292276 Hs 127872 ESTs 3 38 741
424185 AA279752 Hs 142570 Homo sapiens clone 24629 mRNA sequence 316 740
429783 AA811987 Hs 125779 ESTs 313 738
429268 AA205386 Hs 198481 RAR-related orphan receptor B 348 738
400708 c11p1 1292 exon 333 735
402598 BE314624 Hs 3128 polymerase (RNA) II (DNA directed) polyp 304 733
455377 AW905347 gb QV2-NN 1073-220400-159-f06 NN1073 Homo 303 733
435070 AI821270 Hs 116930 ESTs 303 733
405427 cNp3 17682 exon 303 725
455149 AW861879 gb CMO-CT0341-260100-160-h12 CT0341 Homo 3 56 724
402816 dp3 2531 exon 3 13 721
422890 Z43784 Hs 78713 solute earner family 25 (mitochondrial 340 7 15
422297 AW961290 Hs 155615 ESTs 344 710
412686 AW984068 gb RC0-HN0006-16O300 011-e06 HN0006 Homo 391 709
436383 BE065178 gb RC1 -BT0314-020200-012- 01 BT0314 Homo 3 09 09
412290 BE069037 gb QV3-BT0379-161299-040-e12 BT0379Homo 304 708
415486 H12214 Hs 13284 ESTs 422 707
407728 AW071502 Hs 175931 ESTs 305 706
448548 R13209 Hs 21413 solute earner family 12, (potassium-chl 593 705
417275 X63578 Hs 81849 parvalbumin 408 704
418425 AI871247 Hs 6262 ESTs 410 704
440558 AA889574 Hs 177511 ESTs 328 704
411427 AW846080 gb MR3-CT0176-081099 002-b09 CT0176 Homo 3 11 703
422272 AI452421 Hs 77965 Clk-associat g RS-cyclophilm 339 703
410816 AW806175 gb MR1-UM0108-130400-003-a06 UM0108 Homo 330 702
418375 NM 003081 Hs 84389 synaptosomal associated protein, 25kD 9 93 701
421627 AI138551 Hs 97318 ESTs 3 10 701
447258 BE047911 gb tz44a05 y1 NCI CGAP Brn52 Homo sapien 309 699
455547 AW994078 gb RC3-BN0036-090200011-h02 BN0036 Homo 335 698
432209 AW971278 gb EST383367 MAGE resequences, MAGL Homo 349 692
404541 c8p1 6409 exon 4 62 689
451539 AA059467 Hs 218933 ESTs 301 688
429954 AI918130 Hs 21374 ESTs 382 687
411138 AW819500 gb RC5 ST0293-180100 012-C07 ST0293 Homo 3 08 687
447464 AW444957 Hs 201897 ESTs Weakly similar to ALU4 HUMAN ALU S 333 685
454713 AW815111 gb QV4-ST0212-091199-023-c09 ST0212 Homo 3 16 684
415734 NM 014747 Hs 78748 KIAA0237 gene product 500 684
429667 AA456275 Hs 44841 ESTs 309 680
403008 c21p3 2374 exon 3 04 678
446079 T56522 Hs 154030 ESTs 3 11 675
441869 NM 003947 Hs 8004 huntingtm associated protein mteractin 449 675
437804 AA828257 Hs 124324 ESTs 3 42 673
436454 AA757615 Hs 291509 ESTs 301 672
416334 H53139 Hs 36271 ESTs 3 12 670
455965 BE167014 gb CM2-HT0502-140200-088 d08 HT0502 Homo 305 668
445085 AI569295 Hs 179285 ESTs 319 668
445611 AW418497 Hs 145583 ESTs 361 668
437762 T78028 Hs 154679 synaptotagmin 1 7 21 668
416268 H49111 gb yo21c07 r1 Soares adult brain N2b5HB5 302 6 67
449766 AI668690 Hs 54773 ESTs 325 664
443100 AI033188 gb ow94e08 s1 Soares.fetal.liver.spleen. 307 664
408070 AW148852 gb xf05d05 x1 NCI CGAP Bm35 Homo sapien 312 660
451602 AW008846 Hs 60857 ESTs 305 659
441447 AA934077 Hs 126980 ESTs 406 659
445078 AI869975 Hs 4775 junctophilin 3 425 659
434501 AF143878 Hs 194152 Homo sapiens clone IMAGE 115304 mRNA seq 325 658
415960 R49020 Hs 24974 ESTs 334 658
403395 c3p1 11541 exon 3 59 657
403061 c2p1 10450 exon 306 656
419232 AI382037 Hs 87421 ESTs 328 656
425984 AW836277 Hs 165636 hypothedcal protein DKFZp761C07121 6 50 656
403717 c4p1 3133 exon 352 653
452178 AW043576 Hs 171929 ESTs 338 653
455758 R15709 Hs 284231 Novel human gene mapping to chomosome 22 442 652
433858 N69243 Hs 192974 Homo sapiens cDNA FU12735 fis, clone NT 358 652
425440 AA357518 gb EST66256 LNCAP cells I Homo sapiens c 3 15 649
419412 AW161058 Hs 90297 synuclem, beta 560 647
423678 AW963357 Hs 7847 ESTs 347 647
416625 R97839 Hs 35758 ESTs 3 10 646
451854 T92536 Hs 194096 ESTs 328 646
406732 AA487229 Hs 2064 vimentm 371 644
434619 H43163 Hs 32810 ESTs 305 644
413797 BE167274 Hs 5996 ESTs 323 644
438612 AW977980 Hs 292129 ESTs 339 642
412317 AW991979 gb RC1-BN0014-210100 012-f05 BN0014 Homo 346 642
422159 N76767 Hs 153406 ESTs 303 641 429290 AF203032 Hs 198760 neurofilament, heavy polypeptide (200kD) 346 635
427334 R44789 Hs 119486 ESTs, Weakly similar lo transmembrane re 393 635
453839 AL138417 gb DKFZp434B1729_r1 434 (synonym htes3) 306 634
429096 AB011106 Hs 196012 KIAA0534 protein 312 633
444609 AW571659 Hs 278081 ESTs 330 633
419515 S81944 Hs 90791 gamma-aminobutync actd (GABA) A recepto 311 633
418900 BE207357 Hs 301709 ESTs 314 630
437979 AA774318 Hs 121708 ESTs 325 629
410359 R38624 Hs 106313 ESTs 474 628
415990 R76929 Hs 29633 ESTs 339 628
419392 W28573 gb 51f10 Human retina cDNA randomly pπm 300 628
424312 AB013452 Hs 144931 ATPase, ammophospholipid transporter (A 306 626
444762 AI733700 Hs 143883 ESTs 309 625
447785 AL041765 Hs 161423 ESTs 305 622
418199 AA884555 Hs 86603 ESTs 355 622
440582 AA993337 Hs 129082 ESTs 373 621
457766 AU 19470 Hs 145631 ESTs 369 621
426814 AF036943 Hs 172619 KIAA1106 protein 471 621
412018 BE148152 gb RC4-HT0231-041199 012-b04 HT0231 Homo 336 621
414699 AI815523 Hs 76930 synuclein, alpha (non A4 component of am 368 619
420127 AA360399 Hs 44811 ESTs 354 618
418833 AW974899 Hs 292776 ESTs 308 618
441265 AA927180 Hs 153261 ESTs 321 6 17
413408 R51793 Hs 21745 ESTs 356 615
434512 AW139932 Hs 188941 ESTs 356 615
422253 W81526 Hs 118329 ESTs 504 6 10
439950 AW937417 Hs 293561 ESTs 324 610
417210 N99228 Hs 49162 ESTs 354 610
414306 BE272198 Hs 283869 Human DNA sequence from clone RP5-1013A2 335 610
411265 AW834695 gb RC0-LT0001-261199 031-D05 LT0001 Homo 307 610
412734 AW993498 gb RC2-BN0033-170300-019-b08 BN0033 Homo 336 609
425172 AA447729 Hs 12714 ESTs 540 606
451759 W23161 Hs 32886 ESTs 321 602
432154 AI701523 Hs 112577 ESTs 350 602
401313 c13p1_435 exon 392 596
446951 AI350575 Hs 156730 ESTs 320 595
440917 AA909651 Hs 160025 ESTs 306 594
405961 phO 14521 exon 3 12 591
428737 AA984728 Hs 192760 kinesin family member 5A 305 590
417292 N69197 Hs 191361 ESTs 362 589
448681 AU 09781 Hs 21754 Homo sapiens mRNA full length insert cDN 3 52 588
452524 AW136499 Hs 29796 Homo sapiens mRNA cDNA DKFZp434D1319 (f 307 588
426575 M74826 Hs 170808 glutamate decarboxylase 2 (pancreatic is 408 587
423641 AU 37256 Hs 130489 Homo sapiens mRNA, cDNA DKFZp761K0912 (f 328 587
420755 AI699437 Hs 165268 ESTs 317 586
448116 AW352276 Hs 170700 ESTs 3 28 586
412694 AW984373 gb PM3-HN0011-200300 001-f01 HN0011 Homo 300 583
437612 AA827715 Hs 105153 Homo sapiens cDNA FLJ 14230 fis, clone NT 309 582
411522 AW850286 gb IL3-CT0219-161199 031-H11 CT0219 Homo 3 26 5 81
456910 BE185921 Hs 98073 ESTs 320 580
439915 AI521791 Hs 252358 ESTs 355 580
404403 c8p1 1094 exon 323 580
405332 cNp3 13017 exon 351 578
411167 AW820204 gb QV2-ST0296-190100-029-C11 ST0296 Homo 304 578
416139 H21109 Hs 172853 ESTs 363 577
434222 AF119886 Hs 283941 Homo sapiens PR02591 mRNA, complete eds 365 577
415247 F02431 Hs 6581 ESTs 3 08 575
446037 AI076806 Hs 282965 ESTs 342 575
450478 AW451709 Hs 271200 ESTs 380 572
446588 AV659343 Hs 282954 ESTs 329 572
413118 BE065939 gb RC3-BT0319-100100-012-C11 BT0319 Homo 303 572
416946 NM 012324 Hs 80545 mitogen-activated protein kinase 8 inter 391 572
454751 AW819132 gb RC3-ST0281-240400 015.10 ST0281 Homo 306 572
457194 H20669 Hs 35406 ESTs, Highly similar to unnamed protein 354 571
438601 AA811713 Hs 163222 ESTs 326 571
439032 AA829487 Hs 274412 similar to yeast Upf3, variant A 3 10 567
408940 M58583 Hs 662 cerebellin 1 precursor 332 567
437700 AA766060 Hs 122848 ESTs 323 566
416061 R45516 Hs 26119 ESTs 385 565
452861 BE177663 gb RC1 -HT0598-020300-011-h 11 HT0598 Homo 304 564
430330 AA476583 Hs 132981 ESTs 351 563
435312 AJ243396 Hs 4865 voltage gated sodium channel beta 3 subu 567 562
400710 c11p1_1297 exon 304 561
457130 NM 005651 Hs 183671 tryptophan 2,3-dιoxygenase 331 560
434513 AF143888 Hs 18213 Homo sapiens clone IMAGE 121736 mRNA seq 393 560
434277 X77748 Hs 3786 glutamate receptor, metabotropic 3 367 558
440854 AW444900 Hs 246715 ESTs 330 558
457086 AA412591 Hs 204685 ESTs 337 557
431883 AA731404 Hs 105510 ESTs 3 67 556
400758 AA158742 Hs 225084 Homo sapiens cDNA FU14280 fis, clone PL 343 555
455374 AW904039 gb CM3-NN1040-2OO400-156-d03 NN1040 Homo 336 552
440750 AW105131 Hs 245405 ESTs 310 550
451865 H43737 Hs 33186 ESTs, Weakly similar to unknown protein 338 550 453100 AW806871 Hs 224786 ESTs 330 549 433940 H05129 Hs 7459 cyclic AMP-regulated phosphoprotein, 21 324 549 454935 AW846075 gb MR3-CT0176-081099-002 b02 CT0176 Homo 326 548 435447 AI872932 Hs 142442 HP1 BP74 389 547 402953 c20p3_3451 exon 328 547 456233 AA203339 gb zx56a01 r1 Soares.fetal.liver.spleeπ. 302 547 407718 AW070784 Hs 243243 EST 330 545 417429 AI950629 Hs 286237 Homo sapiens cDNA FLJ11841 fis, clone HE 331 538 446408 AI797169 Hs 208486 ESTs 307 537 441792 AW873635 Hs 143962 ESTs 319 535 450661 AW952160 Hs32916 ESTs 370 535 433932 AW954599 Hs 169330 neuronal protein 678 533 427002 AA524093 Hs 23158 ESTs 400 532 428741 AA461386 gb zx70h06 r1 Soares.total.fetus Nb2HF8_ 310 532 446383 T05816 Hs 92511 EST 339 530 442988 A1026130 Hs 131683 ESTs 307 529 426713 AI655299 Hs 130055 ESTs 333 529 421294 AA713486 Hs 180291 ESTs 344 528 406452 ph2_21981 exon 320 528 423508 AW604297 Hs 129711 hepatitis A virus cellular receptor 1 326 527 442114 BE217975 Hs 157021 ESTs 332 526 432508 AI808915 Hs 190201 ESTs 346 526 425604 U94320 Hs 158330 neuropepdde Y receptor Y5 326 523 417925 R26789 Hs 23995 ESTs 308 523 444448 H66317 Hs 143660 ESTs 381 522 413024 AF036268 Hs75149 SH3-domaιn GRB2-lιke 2 371 522 437911 AA848010 Hs 124250 ESTs 311 518 435406 F26698 Hs4884 calcium/calmodulin-depeπdent protein km 495 517 407131 R98679 gb yr31c03 s1 Soares fetal liver spleen 330 516 435776 AI537162 Hs 263988 ESTs 314 513 455532 AW984828 gb RC1-HN0015-120400-021-h11 HN0015 Homo 314 513 457352 AA489099 gb aa56h09 s1 NCI_CGAP_GCB1 Homo sapiens 348 512 428670 AA431682 Hs 134832 ESTs 317 512 445962 AI268410 Hs 201386 ESTs 314 512 418153 R13696 Hs 112830 ESTs 316 510 440565 AW103823 Hs 131586 ESTs 308 510 431446 AW294929 Hs 255369 Homo sapiens cDNA FLJ10265 fis, clone HE 342 509 456036 BE536554 Hs75839 zinc finger protein 6 (CMPX1 ) 321 509 420883 AI735488 Hs 111436 ESTs 317 508 455528 AW984757 gb RC1-HN0015-040400-011-g10 HN0015 Homo 335 508 408442 R59608 Hs 21435 ESTs 310 507 446093 AI346849 Hs 145896 ESTs 330 506 403489 c3p1_2255 exon 343 505 405278 cNp3_1070 exon 305 503 412804 H18857 Hs 22547 ESTs 363 503 458407 W90022 Hs 186809 ESTs, Highly similar to LECT2 precursor 352 503 407367 AA130773 gb zo13d01 r1 Stratagene colon (937204) 351 502 439108 AW163034 Hs 6467 syπaptogyπn 3 563 501 445335 AI220339 Hs 166775 ESTs 321 501 435404 A1240661 Hs 124995 ESTs 399 500
TABLE 6B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
410837 282574.1 AW806917 AW866469 BF898475 BF898476 AW866540 AW866614 BE145698 AW866575
436812 659779.1 AW978773 AW298067 AA810101 AW194180 AA731645 AI690673
454171 1049240.1 AW854832 AW854798 AW854857 AW854816 AW854834 AW854817
454589 28039.6 BG674750 BF374578 AW810080 AW810106 AW810084 BF374755 AW809621 BF374734 BF374590 BF374594 AW809699 BF374588 AW810437
AW810161 AW809662 AW810151
417159 2075888.1 R01760 N49787 R01761 459349 1027822.1 AW749381 H93337 414187 315279 1 BE259777 BE312141 BF942980 423280 881045.1 AW955178 H86636AA324037 431400 1233916.1 AW969094 AA504607 AA504705 454566 164604.1 AW807605 AW807690 AW807677 AW807752 AW807673 AW807900 AW807955 AW807679 AW807615 AW807917 AW807849 AW807832 AW807821
AW807842 AW807827 AW807754 AW807830 AW807829 AW807825 AW807819 AW807769 AW807685 AW807603 AW807763 AW807612 AW807840
AW807908 AW807684 AW807609 AW807596 AW807595 AW807593 AW807907 AW807902 AW807846 AW807756 AW807687 AW807836 AW807835
AW807770 AW807753 AW807669 AW807678 AW807686 AW807680 AW807688 AW807847 AW807957 AW807674 AW807602 AW807617 AW807921
AW807667 AW807952 AW807918 AW807670 AW807760 AW807956 AW807608 AW807683 AW807839 AW807601 AW807822 AW807898
437948 3303971 AA772920 D59870 D61151 AI591331 BF960996
438919 12426181 AW979114 AA828060 AA837606 AA829203
454578 16703 BE150647 AW971143 AW809224 AW809221 BF753820 AW809220 AW809178 AW809150 AW809195 AW809175
455836 15188241 BE145800 BE145921 BE145873 BE145871 BE145930 BE145797 BE145795
454968 10856771 AW848279 AW849039 AW847956 AW847957 AW849046 AW848698 AW849034 AW849033
418162 2189291 1 T11756 T20135 T19729 T11958 T11816 R45874
431169 12357601 AW971240 AA493723 AA493843
458172 363900 ϊ BE007237 BE546311 AA984819 BI256810 W19919 BE007263 BG000322 BF327011 AA890198 BE007496
412172 7090341 W04156AW897535 N94221
427942 4658471 BE543651 AA417856 AV756446 BG505084 BI460307 BI460993 BG613293
454688 106648? 1 BF375123 AW814472 AW814474 AW813343 AW816161 AW813380 AW813300 455675 1490763 1 BE065984 BE066085 BE065942 BE065955 455644 1489581.1 BE064521 BE064441 BE064426 BE064285 BE064286 451496 85420.1 AA046879 BF327988 AW503407 AA018131 424617 895912.1 AW963059 AA344151 AA344472 454962 323094.1 AW853945 AW854083 BF962818 AW847791 BI035483 AW847645 BF961514 BF963484 BF952264 BF963521 455260 231032 1 BE161805 AW878317 BE161759 BF870032 BF869588 434589 14676 1 AF147363 T47219 T47218 410926 1064369.1 AW810708 AW810808 AW810771 AW810924 409623 830636.1 AW4496658E220971 AW449185 437254 1239876 1 AW976161 AA831258 AA765857AA747712AI784019 415508 1874742.1 R45579 F10822 R39236 413263 1497122.1 BE075132 BE075131 BE075130 D60395 BF688035 415967 1899490.1 H49130 H11230 BF363165 H49061 H11124 417555 1978200 1 AA203678 AL597143 H65366 413547 1520005.1 BE147456 BE147563 BE147708 BE147440 411132 1070974.1 AW819177AW819242AW819191 AW819175AW819252AW819244AW819265AW819269 AW819190AW819268 AW819183AW819246 AW819194
AW819249 AW819186AW819180AW819188 BE158470AW819251 BE152602AW819263
454568 1061859.1 AW807909 AW807824 AW807826 AW807903 AW807766 AW807750 AW807911 BE141434 AW807611 AW807837 AW807899 BF374481 413162 1492355.1 BE068104 BE068096 BE068198 BE068115 BE068102 BE068154 BE068103 455377 154707 1 BF947516 AW905291 BF947512 BF952606 BF952706 BF952525 BF952524 BF952619 BF947500 BF952608 BF952523 BF952532 BF952344
BF746516 BF947614 BF746511 BF952358 AW905400AW905300 BF947617AW905349 BF952531 AW905403 BF952528 BE081655 BF746513
AW905286 BF952868 BF947513 BF947510 BF947618 BF947619 AW905347
455149 1099453.1 AW861879 AW861948 AW858447 AW861873 AW858418 AW861871 412686 1243154.1 AW984068 AW984077 AW984072 436383 46767.1 AJ227879 BE065178 BE065329 412290 1163352 1 BE069037 BE069178 AW936034 AW936025 411427 1083097 1 AW846080 AW846074 AW846118 AW846130 410816 1060611.1 AW806175AW806176 AW806170AW806156 447258 1485710.1 BE617316 BE047911 AA984167 455547 1245954.1 AW994078 BE176183 432209 1235790.1 AW971278 AA528270 AA553447 AW971281 411138 1071173.1 AW819500 AW819503 AW819481 AW819459 BF375618 454713 1067889.1 AW815111 AW815094 AW815218 455965 1555935 1 BE167014 BE167058 BE167062 416268 1959926 1 H41854 H49111 H46317 443100 416959.T BE004743 AW804074 BE089437 BE089439 BE089378 BE089438 BE004795 W02375 AI033188 BF332422 BF332418 BE178660 408070 632273 1 AW148852 BG994152 425440 1228191.1 AW962960 AA357518 AA360531 412317 1164038 1 AW991979 AW991981 AW991983 AW936856 AW991977AW991971 AW936852 453839 3209657 1 AL138417 AL138418 419392 215562.2 W28573 W27418 412018 147109.1 BE148133 BE148132 BF736564 BE148152 BE148159 BF893700 411265 1074383 1 AW834695 AW834717 AW834714 412734 1245451.1 AW993498 AW993484 AW993490 BF512974 412694 1243393.1 AW984388 AW984392 AW984379 AW984351 AW984381 AW984377 AW984366 AW984348 AW984391 AW984373 AW984372 AW984353 AW984362 411522 1089092.1 BE143505 BF374194 BF374190 AW850286 411167 1071740 1 AW820323 AW820314 AW820321 413118 1490760.1 BE066079 BE065939 BE065956 454751 1070838.1 AW819132 AW819122 AW819018 AW819135 AW819126 AW819024AW819012AW819141 452861 319757.1 BE177663 AW994738 AI923735 BF948431 BF948329 455374 1161013.1 AW904029 AW904030 AW904039 AW904031 AW904032 AW904046 454935 1083098 1 AW846075 AW846103 BF333976 AW846077 AW846122 AW846129 AW846095 AW846076 BF333979 BF333978 AW846092 456233 2635744 1 AA203339 AA906160 AA929005 428741 1384399.1 AA461386 AA433841 AA433845 455532 1243692.1 AW984828 AW984787 AW984806 AW984817 AW984826 AW984822 AW984773 AW984786 AW984803 AW984796 457352 1233795.1 AW968968 AA489099 N72933 AA489184 455528 1243660.1 AW984734 AW984757 AW984797 AW984745 407367 4907 1 AF085963 H72550 H72951 AA130773
TABLE 6C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham, et al " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495 Strand Indicates DNA strand from which exons were predicted
N position Indicates nucleotide positions of predicted exons
Pkey Ref Strand NLposition
401412 7940103 Minus 43347-45776
405230 7249032 Minus 97493-97682
402125 4033680 Plus 172732-172868
404289 2769644 Plus 15049-15286,30267-30457
406534 7711477 Plus 40463-40586,41191-41336,41856-41986,4300
405348 2914717 Minus 43310-43462
401081 3478647 Plus 105163-105305
402624 7885063 Minus 31308-31439
405320 3478667 Minus 118511-118926,119175-119331
405476 2121229 Plus 69890-70883
403932 7454203 Minus 8142-8753
406112 9133145 Plus 61863-62028
400708 7249204 Plus 118115-119445
405427 7243901 Minus 6509-6729
402816 6723302 Minus 25104-25291
404541 8318559 Plus 103456-103664 403008 6070396 Plus 94608-9478595096-95233
403395 9438353 Minus 144947-145075
403061 8954192 Plus 142875-143008
403717 7259747 Minus 79166-79758
401313 9212516 Minus 190842-191090
405961 8190197 Plus 45132-45254
404403 7272157 Minus 72053-72238
405332 3169141 Minus 70483-71207
400710 7249204 Plus 156753-157120
402953 9408724 Minus 122603-122743
406452 9588380 Minus 76322-76427
403489 7331314 Minus 38897-39212
405278 6139075 Minus 3863-3965,48234891,5439-5529,6043-6170
TABLE 7A EXTENDED GLIOBLASTOMA SEQUENCES This table includes sequence information for 21 DNA and protein sequences
DNA sequence 1
Gene name- Protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Unigene number: Hs 78867
Probeset Accession #. 93426
Nucleic Acid Accession # NM_002851
Coding sequence 148-7092
1 11 21 31 41 51
I I I I I I
CACACATACG CACGCACGAT CTCACTTCGA TCTATACACT GGAGGATTAA AACAAACAAA 60
CAAAAAAAAC ATTTCCTTCG CTCCCCCTCC CTCTCCACTC TGAGAAGCAG AGGAGCCGCA 120
CGGCGAGGGG CCGCAGACCG TCTGGAAATG CGAATCCTAA AGCGTTTCCT CGCTTGCATT 180
CAGCTCCTCT GTGTTTGCCG CCTGGATTGG GCTAATGGAT ACTACAGACA ACAGAGAAAA 240
CTTGTTGAAG AGATTGGCTG GTCCTATACA GGAGCACTGA ATCAAAAAAA TTGGGGAAAG 300
AAATATCCAA CATGTAATAG CCCAAAACAA TCTCCTATCA ATATTGATGA AGATCTTACA 360
CAAGTAAATG TGAATCTTAA GAAACTTAAA TTTCAGGGTT GGGATAAAAC ATCATTGGAA 420
AACACATTCA TTCATAACAC TGGGAAAACA GTGGAAATTA ATCTCACTAA TGACTACCGT 480
GTCAGCGGAG GAGTTTCAGA AATGGTGTTT AAAGCAAGCA AGATAACTTT TCACTGGGGA 540
AAATGCAATA TGTCATCTGA TGGATCAGAG CATAGTTTAG AAGGACAAAA ATTTCCACTT 600
GAGATGCAAA TCTACTGCTT TGATGCGGAC CGATTTTCAA GTTTTGAGGA AGCAGTCAAA 660
GGAAAAGGGA AGTTAAGAGC TTTATCCATT TTGTTTGAGG TTGGGACAGA AGAAAATTTG 720
GATTTCAAAG CGATTATTGA TGGAGTCGAA AGTGTTAGTC GTTTTGGGAA GCAGGCTGCT 780
TTAGATCCAT TCATACTGTT GAACCTTCTG CCAAACTCAA CTGACAAGTA TTACATTTAC 840
AATGGCTCAT TGACATCTCC TCCCTGCACA GACACAGTTG ACTGGATTGT TTTTAAAGAT 900
ACAGTTAGCA TCTCTGAAAG CCAGTTGGCT GTTTTTTGTG AAGTTCTTAC AATGCAACAA 960
TCTGGTTATG TCATGCTGAT GGACTACTTA CAAAACAATT TTCGAGAGCA ACAGTACAAG 1020
TTCTCTAGAC AGGTGTTTTC CTCATACACT GGAAAGGAAG AGATTCATGA AGCAGTTTGT 1080
AGTTCAGAAC CAGAAAATGT TCAGGCTGAC CCAGAGAATT ATACCAGCCT TCTTGTTACA 1140
TGGGAAAGAC CTCGAGTCGT TTATGATACC ATGATTGAGA AGTTTGCAGT TTTGTACCAG 1200
CAGTTGGATG GAGAGGACCA AACCAAGCAT GAATTTTTGA CAGATGGCTA TCAAGACTTG 1260
GGTGCTATTC TCAATAATTT GCTACCCAAT ATGAGTTATG TTCTTCAGAT AGTAGCCATA 1320
TGCACTAATG GCTTATATGG AAAATACAGC GACCAACTGA TTGTCGACAT GCCTACTGAT 1380
AATCCTGAAC TTGATCTTTT CCCTGAATTA ATTGGAACTG AAGAAATAAT CAAGGAGGAG 1440
GAAGAGGGAA AAGACATTGA AGAAGGCGCT ATTGTGAATC CTGGTAGAGA CAGTGCTACA 1500
AACCAAATCA GGAAAAAGGA ACCCCAGATT TCTACCACAA CACACTACAA TCGCATAGGG 1560
ACGAAATACA ATGAAGCCAA GACTAACCGA TCCCCAACAA GAGGAAGTGA ATTCTCTGGA 1620
AAGGGTGATG TTCCCAATAC ATCTTTAAAT TCCACTTCCC AACCAGTCAC TAAATTAGCC 1680
ACAGAAAAAG ATATTTCCTT GACTTCTCAG ACTGTGACTG AACTGCCACC TCACACTGTG 1740
GAAGGTACTT CAGCCTCTTT AAATGATGGC TCTAAAACTG TTCTTAGATC TCCACATATG 1800
AACTTGTCGG GGACTGCAGA ATCCTTAAAT ACAGTTTCTA TAACAGAATA TGAGGAGGAG 1860
AGTTTATTGA CCAGTTTCAA GCTTGATACT GGAGCTGAAG ATTCTTCAGG CTCCAGTCCC 1920
GCAACTTCTG CTATCCCATT CATCTCTGAG AACATATCCC AAGGGTATAT ATTTTCCTCC 1980
GAAAACCCAG AGACAATAAC ATATGATGTC CTTATACCAG AATCTGCTAG AAATGCTTCC 2040
GAAGATTCAA CTTCATCAGG TTCAGAAGAA TCACTAAAGG ATCCTTCTAT GGAGGGAAAT 2100
GTGTGGTTTC CTAGCTCTAC AGACATAACA GCACAGCCCG ATGTTGGATC AGGCAGAGAG 2160
AGCTTTCTCC AGACTAATTA CACTGAGATA CGTGTTGATG AATCTGAGAA GACAACCAAG 2220
TCCTTTTCTG CAGGCCCAGT GATGTCACAG GGTCCCTCAG TTACAGATCT GGAAATGCCA 2280
CATTATTCTA CCTTTGCCTA CTTCCCAACT GAGGTAACAC CTCATGCTTT TACCCCATCC 2340
TCCAGACAAC AGGATTTGGT CTCCACGGTC AACGTGGTAT ACTCGCAGAC AACCCAACCG 2400
GTATACAATG GTGAGACACC TCTTCAACCT TCCTACAGTA GTGAAGTCTT TCCTCTAGTC 2460
ACCCCTTTGT TGCTTGACAA TCAGATCCTC AACACTACCC CTGCTGCTTC AAGTAGTGAT 2520
TCGGCCTTGC ATGCTACGCC TGTATTTCCC AGTGTCGATG TGTCATTTGA ATCCATCCTG 2580
TCTTCCTATG ATGGTGCACC TTTGCTTCCA TTTTCCTCTG CTTCCTTCAG TAGTGAATTG 2640
TTTCGCCATC TGCATACAGT TTCTCAAATC CTTCCACAAG TTACTTCAGC TACCGAGAGT 2700
GATAAGGTGC CCTTGCATGC TTCTCTGCCA GTGGCTGGGG GTGATTTGCT ATTAGAGCCC 2760
AGCCTTGCTC AGTATTCTGA TGTGCTGTCC ACTACTCATG CTGCTTCAGA GACGCTGGAA 2820
TTTGGTAGTG AATCTGGTGT TCTTTATAAA ACGCTTATGT TTTCTCAAGT TGAACCACCC 2880
AGCAGTGATG CCATGATGCA TGCACGTTCT TCAGGGCCTG AACCTTCTTA TGCCTTGTCT 2940
GATAATGAGG GCTCCCAACA CATCTTCACT GTTTCTTACA GTTCTGCAAT ACCTGTGCAT 3000
GATTCTGTGG GTGTAACTTA TCAGGGTTCC TTATTTAGCG GCCCTAGCCA TATACCAATA 3060
CCTAAGTCTT CGTTAATAAC CCCAACTGCA TCATTACTGC AGCCTACTCA TGCCCTCTCT 3120
GGTGATGGGG AATGGTCTGG AGCCTCTTCT GATAGTGAAT TTCTTTTACC TGACACAGAT 3180
GGGCTGACAG CCCTTAACAT TTCTTCACCT GTTTCTGTAG CTGAATTTAC A ATACAACA 3240
TCTGTGTTTG GTGATGATAA TAAGGCGCTT TCTAAAAGTG AAATAATATA TGGAAATGAG 3300
ACTGAACTGC AAATTCCTTC TTTCAATGAG ATGGTTTACC CTTCTGAAAG CACAGTCATG 3360
CCCAACATGT ATGATAATGT AAATAAGTTG AATGCGTCTT TACAAGAAAC CTCTGTTTCC 3420
ATTTCTAGCA CCAAGGGCAT GTTTCCAGGG TCCCTTGCTC ATACCACCAC TAAGGTTTTT 3480
GATCATGAGA TTAGTCAAGT TCCAGAAAAT AACTTTTCAG TTCAACCTAC ACATACTGTC 3540
TCTCAAGCAT CTGGTGACAC TTCGCTTAAA CCTGTGCTTA GTGCAAACTC AGAGCCAGCA 3600 TCCTCTGACC CTGCTTCTAG TGAAATGTTA TCTCCTTCAA CTCAGCTCTT ATTTTATGAG 3660
ACCTCAGCTT CTTTTAGTAC TGAAGTATTG CTACAACCTT CCTTTCAGGC TTCTGATGTT 3720
GACACCTTGC TTAAAACTGT TCTTCCAGCT GTGCCCAGTG ATCCAATATT GGTTGAAACC 3780
CCCAAAGTTG ATAAAATTAG TTCTACAATG TTGCATCTCA TTGTATCAAA TTCTGCTTCA 3840
AGTGAAAACA TGCTGCACTC TACATCTGTA CCAGTTTTTG ATGTGTCGCC TACTTCTCAT 3900
ATGCACTCTG CTTCACTTCA AGGTTTGACC ATTTCCTATG CAAGTGAGAA ATATGAACCA 3960
GTTTTGTTAA AAAGTGAAAG TTCCCACCAA GTGGTACCTT CTTTGTACAG TAATGATGAG 4020
TTGTTCCAAA CGGCCAATTT GGAGATTAAC CAGGCCCATC CCCCAAAAGG AAGGCATGTA 4080
TTTGCTACAC CTGTTTTATC AATTGATGAA CCATTAAATA CACTAATAAA TAAGCTTATA 4140
CATTCCGATG AAATTTTAAC CTCCACCAAA AGTTCTGTTA CTGGTAAGGT ATTTGCTGGT 4200
ATTCCAACAG TTGCTTCTGA TACATTTGTA TCTACTGATC ATTCTGTTCC TATAGGAAAT 4260
GGGCATGTTG CCATTACAGC TGTTTCTCCC CACAGAGATG GTTCTGTAAC CTCAACAAAG 4320
TTGCTGTTTC CTTCTAAGGC AACTTCTGAG CTGAGTCATA GTGCCAAATC TGATGCCGGT 4380
TTAGTGGGTG GTGGTGAAGA TGGTGACACT GATGATGATG GTGATGATGA TGATGACAGA 4440
GATAGTGATG GCTTATCCAT TCATAAGTGT ATGTCATGCT CATCCTATAG AGAATCACAG 4500
GAAAAGGTAA TGAATGATTC AGACACCCAC GAAAACAGTC TTATGGATCA GAATAATCCA 4560
ATCTCATACT CACTATCTGA GAATTCTGAA GAAGATAATA GAGTCACAAG TGTATCCTCA 4620
GACAGTCAAA CTGGTATGGA CAGAAGTCCT GGTAAATCAC CATCAGCAAA TGGGCTATCC 4680
CAAAAGCACA ATGATGGAAA AGAGGAAAAT GACATTCAGA CTGGTAGTGC TCTGCTTCCT 4740
CTCAGCCCTG AATCTAAAGC ATGGGCAGTT CTGACAAGTG ATGAAGAAAG TGGATCAGGG 4800
CAAGGTACCT CAGATAGCCT TAATGAGAAT GAGACTTCCA CAGATTTCAG TTTTGCAGAC 4860
ACTAATGAAA AAGATGCTGA TGGGATCCTG GCAGCAGGTG ACTCAGAAAT AACTCCTGGA 4920
TTCCCACAGT CCCCAACATC ATCTGTTACT AGCGAGAACT CAGAAGTGTT CCACGTTTCA 4980
GAGGCAGAGG CCAGTAATAG TAGCCATGAG TCTCGTATTG GTCTAGCTGA GGGGTTGGAA 5040
TCCGAGAAGA AGGCAGTTAT ACCCCTTGTG ATCGTGTCAG CCCTGACTTT TATCTGTCTA 5100
GTGGTTCTTG TGGGTATTCT CATCTACTGG AGGAAATGCT TCCAGACTGC ACACTTTTAC 5160
TTAGAGGACA GTACATCCCC TAGAGTTATA TCCACACCTC CAACACCTAT CTTTCCAATT 5220
TCAGATGATG TCGGAGCAAT TCCAATAAAG CACTTTCCAA AGCATGTTGC AGATTTACAT 5280
GCAAGTAGTG GGTTTACTGA AGAATTTGAG ACACTGAAAG AGTTTTACCA GGAAGTGCAG 5340
AGCTGTACTG TTGACTTAGG TATTACAGCA GACAGCTCCA ACCACCCAGA CAACAAGCAC 5400
AAGAATCGAT ACATAAATAT CGTTGCCTAT GATCATAGCA GGGTTAAGCT AGCACAGCTT 5460
GCTGAAAAGG ATGGCAAACT GACTGATTAT ATCAATGCCA ATTATGTTGA TGGCTACAAC 5520
AGACCAAAAG CTTATATTGC TGCCCAAGGC CCACTGAAAT CCACAGCTGA AGATTTCTGG 5580
AGAATGATAT GGGAACATAA TGTGGAAGTT ATTGTCATGA TAACAAACCT CGTGGAGAAA 5640
GGAAGGAGAA AATGTGATCA GTACTGGCCT GCCGATGGGA GTGAGGAGTA CGGGAACTTT 5700
CTGGTCACTC AGAAGAGTGT GCAAGTGCTT GCCTATTATA CTGTGAGGAA TTTTACTCTA 5760
AGAAACACAA AAATAAAAAA GGGCTCCCAG AAAGGAAGAC CCAGTGGACG TGTGGTCACA 5820
CAGTATCACT ACACGCAGTG GCCTGACATG GGAGTACCAG AGTACTCCCT GCCAGTGCTG 5880
ACCTTTGTGA GAAAGGCAGC CTATGCCAAG CGCCATGCAG TGGGGCCTGT TGTCGTCCAC 5940
TGCAGTGCTG GAGTTGGAAG AACAGGCACA TATATTGTGC TAGACAGTAT GTTGCAGCAG 6000
ATTCAACACG AAGGAACTGT CAACATATTT GGCTTCTTAA AACACATCCG TTCACAAAGA 6060
AATTATTTGG TACAAACTGA GGAGCAATAT GTCTTCATTC ATGATACACT GGTTGAGGCC 6120
ATACTTAGTA AAGAAACTGA GGTGCTGGAC AGTCATATTC ATGCCTATGT TAATGCACTC 6180
CTCATTCCTG GACCAGCAGG CAAAACAAAG CTAGAGAAAC AATTCCAGCT CCTGAGCCAG 6240
TCAAATATAC AGCAGAGTGA CTATTCTGCA GCCCTAAAGC AATGCAACAG GGAAAAGAAT 6300
CGAACTTCTT CTATCATCCC TGTGGAAAGA TCAAGGGTTG GCATTTCATC CCTGAGTGGA 6360
GAAGGCACAG ACTACATCAA TGCCTCCTAT ATCATGGGCT ATTACCAGAG CAATGAATTC 6420
ATCATTACCC AGCACCCTCT CCTTCATACC ATCAAGGATT TCTGGAGGAT GATATGGGAC 6480
CATAATGCCC AACTGGTGGT TATGATTCCT GATGGCCAAA ACATGGCAGA AGATGAATTT 6540
GTTTACTGGC CAAATAAAGA TGAGCCTATA AATTGTGAGA GCTTTAAGGT CACTCTTATG 6600
GCTGAAGAAC ACAAATGTCT ATCTAATGAG GAAAAACTTA TAATTCAGGA CTTTATCTTA 6660
GAAGCTACAC AGGATGATTA TGTACTTGAA GTGAGGCACT TTCAGTGTCC TAAATGGCCA 6720
AATCCAGATA GCCCCATTAG TAAAACTTTT GAACTTATAA GTGTTATAAA AGAAGAAGCT 6780
GCCAATAGGG ATGGGCCTAT GATTGTTCAT GATGAGCATG GAGGAGTGAC GGCAGGAACT 6840
TTCTGTGCTC TGACAACCCT TATGCACCAA CTAGAAAAAG AAAATTCCGT GGATGTTTAC 6900
CAGGTAGCCA AGATGATCAA TCTGATGAGG CCAGGAGTCT TTGCTGACAT TGAGCAGTAT 6960
CAGTTTCTCT ACAAAGTGAT CCTCAGCCTT GTGAGCACAA GGCAGGAAGA GAATCCATCC 7020
ACCTCTCTGG ACAGTAATGG TGCAGCATTG CCTGATGGAA ATATAGCTGA GAGCTTAGAG 7080
TCTTTAGTTT AACACAGAAA GGGGTGGGGG GACTCACATC TGAGCATTGT TTTCCTCTTC 7140
CTAAAATTAG GCAGGAAAAT CAGTCTAGTT CTGTTATCTG TTGATTTCCC ATCACCTGAC 7200
AGTAACTTTC ATGACATAGG ATTCTGCCGC CAAATTTATA TCATTAAGAA TGTGTGCCTT 7260
TTTGCAAGAC TTGTAATTTA CTTATTATGT TTGAACTAAA ATGATTGAAT TTTACAGTAT 7320
TTCTAAGAAT GGAATTGTGG TATTTTTTTC TGTATTGATT TTAACAGAAA ATTTCAATTT 7380
ATAGAGGTTA GGAATTCCAA ACTACAGAAA ATGTTTGTTT TTAGTGTCAA ATTTTTAGCT 7440
GTATTTGTAG CAATTATCAG GTTTGCTAGA AATATAACTT TTAATACAGT AGCCTGTAAA 7500
TAAAACACTC TTCCATATGA TATTCAACAT TTTACAACTG CAGTATTCAC CTAAAGTAGA 7560
AATAATCTGT TACTTATTGT AAATACTGCC CTAGTGTCTC CATGGACCAA ATTTATATTT 7620
ATAATTGTAG ATTTTTATAT TTTACTACTG AGTCAAGTTT TCTAGTTCTG TGTAATTGTT 7680
TAGTTTAATG ACGTAGTTCA TTAGCTGGTC TTACTCTACC AGTTTTCTGA CATTGTATTG 7740
TGTTACCTAA GTCATTAACT TTGTTTCAGC ATGTAATTTT AACTTTTGTG GAAAATAGAA 7800
ATACCTTCAT TTTGAAAGAA GTTTTTATGA GAATAACACC TTACCAAACA TTGTTCAAAT 7860
GGTTTTTATC CAAGGAATTG CAAAAATAAA TATAAATATT GCCATTAAAA AAAAAAAAAA 7920 AAAAAAAAAA AAAAAAAAAA A
Protein sequence 1
Gene name: Protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Unigene number: Hs.78867
Protein Accession #: NP__002842
Signal sequence: 1-20
Pfam domain: carb anhydrase [38-300]
Transmembrane domains : 1639-1661
Cellular Localization: plasma membrane
1 11 21 31
I I MRILKRFLAC IQLLCVCRI-D WANGYYRQQR KLVEEIGWSY TGALNQKNWG KKYPTCNSPK 60
QSPINIDEDL TQVNVNLKKL KFQGHDKTSL ENTFIHNTGK TVEINLTNDY RVSGGVSEMV 120
FKASKITFHW GKCNMSSDGS EHSLEGQKFP LEMQIYCFDA DRFSSFEEAV KGKGKLRALS 180
ILFEVGTEEN LDFKAIIDGV ESVSRFGKQA ALDPFILLNL LPNSTDKYYI YNGSLTSPPC 240
TDTVDWIVFK DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY 300
TGKEEIHEAV CSSEPENVQA DPENYTSLLV TWERPRWYD TMIEKFAVLY QQLDGEDQTK 360
HEFLTDGYQD LGAILNNLLP NMSYVLQI A ICTNGLYGKY SDQLIVDMPT DNPELDLFPE 420
LIGTEEIIKE EEEGKDIEEG AIVNPGRDSA TNQIRKKEPQ ISTTTHYNRI GTKYNEAKTN 480
RSPTRGSEFS GKGDVPNTSL NSTSQPVTK ATEKDISLTS QTVTELPPHT VEGTSASLND 540
GSKTVLRSPH MNLSGTAESL NTVSITEYEE ESLLTSFKLD TGAEDSSGSS PATSAIPFIS 600
ENISQGYIFS SENPETITYD VLIPESARNA SEDSTSSGSE ESLKDPS EG NVWFPSSTDI 660
TAQPDVGSGR ESFLQTNYTE IRVDESEKTT KSFSAGPVMS QGPSVTDLEM PHYSTFAYFP 720
TEVTPHAFTP SSRQQDLVST VNWYSQTTQ PVYNGETPLQ PSYSSEVFPL VTPLLLDNQI 780
LNTTPAASSS DSA HATPVF PSVDVSFESI LSSYDGAPLL PFSSASFSSE LFRHLHTVSQ 840
ILPQVTSATE SDKVPLHAS PVAGGDLLLE PSLAQYSDVL STTHAASETL EFGSESGVLY 900
KTLMFSQVEP PSSDAMMHAR SSGPEPSYAL SDNEGSQHIF TVSYSSAIPV HDSVGVTYQG 960
SLFSGPSHIP IPKSSLITPT ASLLQPTHAL SGDGE SGAS SDSEFLLPDT DGLTALNISS 1020
PVSVAEFTYT TSVFGDDNKA LSKSEIIYGN ETELQIPSFN EMVYPSESTV MPNMYDNVNK 1080
LNASLQETSV SISSTKGMFP GSLAHTTTKV FDHEISQVPE NNFSVQPTHT VSQASGDTSL 1140
KPVLSANSEP ASSDPASSEM LSPSTQLLFY ETSASFSTEV LLQPSFQASD VDTLLKTVLP 1200
AVPSDPILVE TPKVDKISST MLHLIVSNSA SSENMLHSTS VPVFDVSPTS HMHSASLQGL 1260
TISYASEKYE PVLLKSESSH QWPSLYSND ELFQTANLEI NQAHPPKGRH VFATPVLSID 1320
EPLNTLINKL IHSDEILTST KSSVTGKVFA GIPTVASDTF VSTDHSVPIG NGHVAITAVS 1380
PHRDGSVTST KLLFPSKATS ELSHSAKSDA GLVGGGEDGD TDDDGDDDDD RDSDGLSIHK 1440
CMSCSSYRES QEKVMNDSDT HENSLMDQNN PISYSLSENS EEDNRVTSVS SDSQTGMDRS 1500
PGKSPSANGL SQKHNDGKEE NDIQTGSALL PLSPESKAWA VLTSDEESGS GQGTSDSLNE 1560
NETSTDFSFA DTNEKDADGI LAAGDSEITP GFPQSPTSSV TSENSEVFHV SEAEASNSSH 1620
ESRIGLAEGL ESEKKAVIPL VIVSALTFIC LWLVGILIY WRKCFQTAHF YLEDSTSPRV 1680
ISTPPTPIFP ISDDVGAIPI KHFPKHVADL HASSGFTEEF ETLKEFYQEV QSCTVDLGIT 1740
ADSSNHPDNK HKNRYINIVA YDHSRVKLAQ LAEKDGKLTD YINANYVDGY NRPKAYIAAQ 1800
GPLKSTAEDF WRMIWEHNVE VIVMITNLVE KGRRKCDQY PADGSEEYGN FLVTQKSVQV 1860
LAYYTVRNFT LRNTKIKKGS QKGRPSGRW TQYHYTQWPD MGVPEYSLPV LTFVRKAAYA 1920
KRHAVGP W HCSAGVGRTG TYIVLDSMLQ QIQHEGTVNI FGFLKHIRSQ RNYLVQTEEQ 1980
YVFIHDTLVE AILSKETEVL DSHIHAYVNA LLIPGPAGKT KLEKQFQLLS QSNIQQSDYS 2040
AALKQCNREK NRTSSIIPVE RSRVGISSLS GEGTDYINAS YIMGYYQSNE FIITQHPLLH 2100
TIKDF RMI DHNAQLWMI PDGQNMAEDE FVYWPNKDEP INCESFKVTL MAEEHKCLSN 2160
EEKLIIQDFI LEATQDDYVL EVRHFQCPKH PNPDSPISKT FELISVIKEE AANRDGPMIV 2220
HDEHGGVTAG TFCALTTLMH QLEKENSVDV YQVAKMINLM RPGVFADIEQ YQFLYKVILS 2280
LVSTRQEENP STSLDSNGAA LPDGNIAESL ESLV
DNA SEQUENCE 2
Gene name, tyrosylprotem sulfotransferase
Unigene number: Hs.110903
Probeset Accession #: D61594
Nucleic Acid Accession # NM_003596
Coding sequence: 82-1194
1 11 21 31
GTAGACTGTC CATGGCCTGA ACATTTTCCG AAAATCATTT TGAGCAAAAT ATCTGTTTAA 60
TAACAAGATA ACCACATCAA GATGGTTGGA AAGCTGAAGC AGAACTTACT ATTGGCATGT 120
CTGGTGATTA GTTCTGTGAC TGTGTTTTAC CTGGGCCAGC ATGCCATGGA ATGCCATCAC 180
CGGATAGAGG AACGTAGCCA GCCAGTCAAA TTGGAGAGCA CAAGGACCAC TGTGAGAACT 240
GGCCTGGACC TCAAAGCCAA CAAAACCTTT GCCTATCACA AAGATATGCC TTTAATATTT 300
ATTGGRGGTG TGCCTCGGAG TGGAACCACA CTCATGAGGG CCATGCTGGA CGCACATCCT 360
GACATTCGCT GTGGAGAGGA AACCAGGGTC ATTCCCCGAA TCCTGGCCCT GAAGCAGATG 420
TGGTCACGGT CAAGTAAAGA GAAGATCCGC CTGGATGAGG CTGGTGTTAC TGATGAAGTG 480
CTGGATTCTG CCATGCAAGC CTTCTTACTA GAAATTATCG TTAAGCATGG GGAGCCAGCC 540
CCTTATTTAT GTAATAAAGA TCCTTTTGCC CTGAAATCTT TAACTTACCT TTCTAGGTTA 600
TTCCCCAATG CCAAATTTCT CCTGATGGTC CGAGATGGCC GGGCATCAGT ACATTCAATG 660
ATTTCTCGAA AAGTTACTAT AGCTGGATTT GATCTGAACA GCTATAGGGA CTGTTTGACA 720
AAGTGGAATC GTGCTATAGA GACCATGTAT AACCAGTGTA TGGAGGTTGG TTATAAAAAG 780
TGCATGTTGG TTCACTATGA ACAACTTGTC TTACATCCTG AACGGTGGAT GAGAACACTC 840
TTAAAGTTCC TCCAGATTCC ATGGAACCAC TCAGTATTGC ACCATGAAGA GATGATTGGG 900
AAAGCTGGGG GAGTGTCTCT GTCAAAAGTG GAGAGATCTA CAGACCAAGT AATCAAGCCA 960
GTCAATGTAG GAGCTCTATC AAAATGGGTT GGGAAGATAC CGCCAGATGT TTTACAAGAC 1020
ATGGCAGTGA TTGCTCCTAT GCTTGCCAAG CTTGGATATG ACCCATATGC CAACCCACCT 1080
AACTACGGAA AACCTGATCC CAAAATTATT GAAAACACTC GAAGGGTCTA TAAGGGAGAA 1140
TTCCAACTAC CTGACTTTCT TAAAGAAAAA CCACAGACTG AGCAAGTGGA GTAGCAGAAC 1200
CAGGAGCCTC TTCCATACAT GAGGAAAGAT TGCTGCCTTT TCAGCAGAAG GGAAATTCCT 1260
AGGATTGGCT GTCCCCTGCC AAGCTTGGTG GAGCGTCTGC ACCTTGGCTG CGCCGCCTGT 1320
GCATTTGCCA GTTTCCTCCC ACTGAGAGGA TGGAGGTGTC CGCACAGCTT TGGGCCTCGT 1380
GAGGGATCTG CCTCCTGAGC AAAGAGCTCT TGATCCCGAT TTCATGCACA GCCCTGCAGT 1440
AAGGAGCCCA GAAGGAACAT GTGTTTCCTG TTAAAACTCC TCTTGTTCTC TTTTCTTACA 1500
TTATGACGTT TGTTTTCAAG GAGAGGGTTT AAAAATGGGA TCCTGTAAGC AGACTTGGGC 1560
AGTCTCCTTT TGAAATAGGT TGTCTGTACA TGTTCTAATG TTTTGTAGAA CACGTGTGCC 1620
TGTTTAAGTG TATTGATGTG AATAATATTA AATATCCTAA TTATTTAATT CATTGTATTG 1680
TTTCTGAGAA GTTGGGAAAT TACCATTATA CATTTACAAC CTAATGACTT TTGTATTTTA 1740
TTTTTCAAAA TAAAAGCTTT CAATGTGA
Protein sequence 2
Gene name: tyrosylprotem sulfotransferase 1
Unigene number: Hs.110903
Protein Accession #: NP_003587
Signal sequence: 1-21 Transmembrane domains : none ound
Cellular Localization, plasma membrane
1 11 21 31 41 51
I I I I I I
MVGKLKQNLL LACLVISSVT VFYLGQHAME CHHRIEERSQ PVKLESTRTT VRTGLDLKAN 60
KTFAYHKDMP LIFIGGVPRS GTTLMRAMLD AHPDIRCGEE TRVIPRILAL KQMWSRSSKE 120
KIRLDEAGVT DEVLDSAMQA FLLEIIVKHG EPAPYLCNKD PFALKSLTYL SRLFPNAKFL 180
LMVRDGRASV HSMISRKVTI AGFDLNSYRD CLTKWNRAIE TMYNQCMEVG YKKCMLVHYE 240
QLVLHPER M RTLLKFLQIP WNHSVLHHEE MIGKAGGVSL SKVERSTDQV IKPVNVGALS 300
KWVGKIPPDV LQDMAVIAPM LAKLGYDPYA NPPNYGKPDP KIIENTRRVY KGEFQLPDFL 360 KEKPQTEQVE
DNA sequence 3
Gene name: interieukin 13 receptor, alpha 2 Unigene number: Hs.25954 Probeset Accession #: R52795 Nucleic Acid Accession #: NM_000640 Coding sequence: 94-1236 1 11 21 31 41 51 i i i i i i
CGGATGAAGG CTATTTGAAG TCGCCATAAC CTGGTCAGAA GTGTGCCTGT CGGCGGGGAG 60
AGAGGCAATA TCAAGGTTTT AAATCTCGGA GAAATGGCTT TCGTTTGCTT GGCTATCGGA 120
TGCTTATATA CCTTTCTGAT AAGCACAACA TTTGGCTGTA CTTCATCTTC AGACACCGAG 180
ATAAAAGTTA ACCCTCCTCA GGATTTTGAG ATAGTGGATC CCGGATACTT AGGTTATCTC 240
TATTTGCAAT GGCAACCCCC ACTGTCTCTG GATCATTTTA AGGAATGCAC AGTGGAATAT 300
GAACTAAAAT ACCGAAACAT TGGTAGTGAA ACATGGAAGA CCATCATTAC TAAGAATCTA 360
CATTACAAAG ATGGGTTTGA TCTTAACAAG GGCATTGAAG CGAAGATACA CACGCTTTTA 420
CCATGGCAAT GCACAAATGG ATCAGAAGTT CAAAGTTCCT GGGCAGAAAC TACTTATTGG 480
ATATCACCAC AAGGAATTCC AGAAACTAAA GTTCAGGATA TGGATTGCGT ATATTACAAT 540
TGGCAATATT TACTCTGTTC TTGGAAACCT GGCATAGGTG TACTTCTTGA TACCAATTAC 600
AACTTGTTTT ACTGGTATGA GGGCTTGGAT CATGCATTAC AGTGTGTTGA TTACATCAAG 660
GCTGATGGAC AAAATATAGG ATGCAGATTT CCCTATTTGG AGGCATCAGA CTATAAAGAT 720
TTCTATATTT GTGTTAATGβ ATCATCAGAG AACAAGCCTA TCAGATCCAG TTATTTCACT 780
TTTCAGCTTC AAAATATAGT TAAACCTTTG CCGCCAGTCT ATCTTACTTT TACTCGGGAG 840
AGTTCATGTG AAATTAAGCT GAAATGGAGC ATACCTTTGG GACCTATTCC AGCAAGGTGT 900
TTTGATTATG AAATTGAGAT CAGAGAAGAT GATACTACCT TGGTGACTGC TACAGTTGAA 960
AATGAAACAT ACACCTTGAA AACAACAAAT GAAACCCGAC AATTATGCTT TGTAGTAAGA 1020
AGCAAAGTGA ATATTTATTG CTCAGATGAC GGAATTTGGA GTGAGTGGAG TGATAAACAA 1080
TGCTGGGAAG GTGAAGACCT ATCGAAGAAA ACTTTGCTAC GTTTCTGGCT ACCATTTGGT 1140
TTCATCTTAA TATTAGTTAT ATTTGTAACC GGTCTGCTTT TGCGTAAGCC AAACACCTAC 1200
CCAAAAATGA TTCCAGAATT TTTCTGTGAT ACATGAAGAC TTTCCATATC AAGAGACATG 1260
GTATTGACTC AACAGTTTCC AGTCATGGCC AAATGTTCAA TATGAGTCTC AATAAACTGA 1320
ATTTTTCTTG CGAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 1380 AA
Protein sequence 3
Gene name: interieukin 13 receptor, alpha 2
Unigene number- Hs.25954
Probeset Accession #: R52795
Protein Accession # NP_000631
Signal sequence: 1-23
FN3 domain: 155-322
Transmembrane domains: 340-362
Cellular Localization: plasma membrane
1 11 21 31 41 51
I I I I 1 I
MAFVCLAIGC LYTFLISTTF GCTSSSDTEI KVNPPQDFEI VDPGYLGYLY LQ QPPLSLD 60
HFKECTVEYE LKYRNIGSET KTIITKNLH YKDGFDLNKG IEAKIHTLLP QCTNGSEVQ 120
SSWAETTY I SPQGIPETKV QDMDCVYYNW QYLLCSWKPG IGVLLDTNYN LFYWYEGLDH 180
ALQCVDYIKA DGQNIGCRFP YLEASDYKDF YICVNGSSEN KPIRSSYFTF QLQNIVKPLP 240
PVYLTFTRES SCEIKLK SI PLGPIPARCF DYEIEIREDD TTLVTATVEN ETYTLKTTNE 300
TRQLCFWRS KVNIYCSDDG IWSE SDKQC WEGEDLSKKT LLRFWLPFGF ILILVIFVTG 360 LLLRKPNTYP KMIPEFFCDT
DNA sequence 4
Gene name : chemokine (C-X3 -C) receptor 1
Unigene number : Hs . 78913
Probeset Accession # : U20350
Nucleic Acid Accession # : NM_001337
Coding sequence . 46-1113
1 11 21 31 41 51
I I I I I I
GGGGCAGATC CAGATTCCCT TTGCAGTCCA CGCCAGGCCT TCACCATGGA TCAGTTCCCT 60
GAATCAGTGA CAGAAAACTT TGAGTACGAT GATTTGGCTG AGGCCTGTTA TATTGGGGAC 120
ATCGTGGTCT TTGGGACTGT GTTCCTGTCC ATATTCTACT CCGTCATCTT TGCCATTGGC 180
CTGGTGGGAA ATTTGTTGGT AGTGTTTGCC CTCACCAACA GCAAGAAGCC CAAGAGTGTC 240
ACCGACATTT ACCTCCTGAA CCTGGCCTTG TCTGATCTGC TGTTTGTAGC CACTTTGCCC 300
TTCTGGACTC ACTATTTGAT AAATGAAAAG GGCCTCCACA ATGCCATGTG CAAATTCACT 360
ACCGCCTTCT TCTTCATCGG CTTTTTTGGA AGCATATTCT TCATCACCGT CATCAGCATT 420
GATAGGTACC TGGCCATCGT CCTGGCCGCC AACTCCATGA ACAACCGGAC CGTGCAGCAT 480
GGCGTCACCA TCAGCCTAGG CGTCTGGGCA GCAGCCATTT TGGTGGCAGC ACCCCAGTTC 540
ATGTTCACAA AGCAGAAAGA AAATGAATGC CTTGGTGACT ACCCCGAGGT CCTTCAGGAA 600
ATCTGGCCCG TGCTCCGCAA TGTGGAAACA AATTTTCTTG GCTTCCTACT CCCCCTGCTC 660
ATTATGAGTT ATTGCTACTT CAGAATCATC CAGACGCTGT TTTCCTGCAA GAACCACAAG 720 AAAGCCAAAG CCATTAAACT GATCCTTCTG GTGGTCATCG TGTTTTTCCT CTTCTGGACA 780
CCCTACAACG TTATGATTTT CCTGGAGACG CTTAAGCTCT ATGACTTCTT TCCCAGTTGT 840
GACATGAGGA AGGATCTGAG GCTGGCCCTC AGTGTGACTG AGACGGTTGC ATTTAGCCAT 900
TGTTGCCTGA ATCCTCTCAT CTATGCATTT GCTGGGGAGA AGTTCAGAAG ATACCTTTAC 960
CACCTGTATG GGAAATGCCT GGCTGTCCTG TGTGGGCGCT CAGTCCACGT TGATTTCTCC 1020
TCATCTGAAT CACAAAGGAG CAGGCATGGA AGTGTTCTGA GCAGCAATTT TACTTACCAC 1080
ACGAGTGATG GAGATGCATT GCTCCTTCTC TGAAGGGAAT CCCAAAGCCT TGTGTCTACA 1140
GAGAACCTGG AGTTCCTGAA CCTGATGCTG ACTAGTGAGG AAGATTTTTG TTGTTATTTC 1200
TTACAGGCAC AAAATGATGG ACCCAATGCA CACAAAACAA CCCTAGAGTG TTGTTGAGAA 1260
TTGTGCTCAA AATTTGAAGA ATGAACAAAT TGAACTCTTT GAATGACAAA GAGTAGACAT 1320
TTCTCTTACT GCAAATGTCA TCAGAACTTT TTGGTTTGCA GATGACAAAA ATTCAACTCA 1380
GACTAGTTTA GTTAAATGAG GGTGGTGAAT ATTGTTCATA TTGTGGCACA AGCAAAAAGG 1440 GTGTCTGAGC CCTCAAAGTG AGGGGAACCA GGGCCTGAGC CAAGCTA
Protein sequence 4 Gene name: chemokine (C-X3-C) receptor 1 Unigene number: Hs.78913 Protein Accession #: NP_001328 Signal sequence: 1-44 Pfam domain: 7tm_l [48-293]
Cellular Localization: plasma membrane
1 11 21 31 41 51
I I I I I I
MDQFPESVTE NFEYDDLAEA CYIGDIWFG TVFLSIFYSV IFAIGLVGNL LWFALTNSK 60 KPKSVTDIYL LNI-ALSDLLF VATLPF THY LINEKGLHNA MCKFTTAFFF IGFFGSIFFI 120
TVISIDRYLA IVLAANSMNN RTVQHGVTIS LGVWAAAILV AAPQFMFTKQ KENECLGDYP 180
EVLQEI PVL RNVETNFLGF LLPLLIMSYC YFRIIQTLFS CKNHKKAKAI KLILLWIVF 240
FLFWTPYNVM IFLETLKLYD FFPSCDMRKD LRLALSVTET VAFSHCCLNP LIYAFAGEKF 300 RRYLYHLYGK CLAVLCGRSV HVDFSSSESQ RSRHGSVLSS NFTYHTSDGD ALLLL
DNA sequence 5
Gene name: cannabinoid receptor 1 (brain) Unigene number: Hs.75110 Probeset Accession #: 412986 Nucleic Acid Accession #: NM_001840 Coding sequence: 92-1510 1 11 21 31 41 51
I I I I I I
TCGGCTTATT TGTTTTCCCT CCTCTTAGGA TTGCCCCCTG TGGGTCACTT TCTCAGTCAT 60
TTTGAGCTCA GCCTAATCAA AGACTGAGGT TATGAAGTCG ATCCTAGATG GCCTTGCAGA 120
TACCACCTTC CGCACCATCA CCACTGACCT CCTGTACGTG GGCTCAAATG ACATTCAGTA 180
CGAAGACATC AAAGGTGACA TGGCATCCAA ATTAGGGTAC TTCCCACAGA AATTCCCTTT 240
AACTTCCTTT AGGGGAAGTC CCTTCCAAGA GAAGATGACT GCGGGAGACA ACCCCCAGCT 300
AGTCCCAGCA GACCAGGTGA ACATTACAGA ATTTTACAAC AAGTCTCTCT CGTCCTTCAA 360
GGAGAATGAG GAGAACATCC AGTGTGGGGA GAACTTCATG GACATAGAGT GTTTCATGGT 420
CCTGAACCCC AGCCAGCAGC TGGCCATTGC AGTCCTGTCC CTCACGCTGG GCACCTTCAC 480
GGTCCTGGAG AACCTCCTGG TGCTGTGCGT CATCCTCCAC TCCCGCAGCC TCCGCTGCAG 540
GCCTTCCTAC CACTTCATCG GCAGCCTGGC GGTGGCAGAC CTCCTGGGGA GTGTCATTTT 600
TGTCTACAGC TTCATTGACT TCCACGTGTT CCACCGCAAA GATAGCCGCA ACGTGTTTCT 660
GTTCAAACTG GGTGGGGTCA CGGCCTCCTT CACTGCCTCC GTGGGCAGCC TGTTCCTCAC 720
AGCCATCGAC AGGTACATAT CCATTCACAG GCCCCTGGCC TATAAGAGGA TTGTCACCAG 780
GCCCAAGGCC GTGGTGGCGT TTTGCCTGAT GTGGACCATA GCCATTGTGA TCGCCGTGCT 840
GCCTCTCCTG GGCTGGAACT GCGAGAAACT GCAATCTGTT TGCTCAGACA TTTTCCCACA 900
CATTGATGAA ACCTACCTGA TGTTCTGGAT CGGGGTCACC AGCGTACTGC TTCTGTTCAT 960
CGTGTATGCG TACATGTATA TTCTCTGGAA GGCTCACAGC CACGCCGTCC GCATGATTCA 1020
GCGTGGCACC CAGAAGAGCA TCATCATCCA CACGTCTGAG GATGGGAAGG TACAGGTGAC 1080
CCGGCCAGAC CAAGCCCGCA TGGACATTAG GT AGCCAAG ACCCTGGTCC TGATCCTGGT 1140
GGTGTTGATC ATCTGCTGGG GCCCTCTGCT TGCAATCATG GTGTATGATG TCTTTGGGAA 1200
GATGAACAAG CTCATTAAGA CGGTGTTTGC ATTCTGCAGT ATGCTCTGCC TGCTGAACTC 1260
CACCGTGAAC CCCATCATCT ATGCTCTGAG GAGTAAGGAC CTGCGACACG CTTTCCGGAG 1320
CATGTTTCCC TCTTGTGAAG GCACTGCGCA GCCTCTGGAT AACAGCATGG GGGACTCGGA 1380
CTGCCTGCAC AAACACGCAA ACAATGCAGC CAGTGTTCAC AGGGCCGCAG AAAGCTGCAT 1440
CAAGAGCACA GTCAAGATTG CCAAGGTAAC CATGTCTGTG TCCACAGACA CGTCTGCCGA 1500
GGCTCTGTGA GCCTGATGCC TCCCTGGCAG CACAGGAAAA GAATTTTTTT TTTTAAGCTC 1560
AAAATCTAGA AGAGTCTATT GTCTCCTTGG TTATATTTTT TTAACTTTAC CATGCTCAAT 1620
GAAAAGGTGA TTGTCACCAT GATCACTTAT CAGTTTGCTA ATGTTTCCAT AGTTTAGGTA 1680
CTCAAACTCC ATTCTCCAGG GGTTTACAGT GAAGAAAGCC TGTTGTTTAA GTGACTGAAC 1740
GATCCTTCAA AGTCTCAATG AAATAGGAGG GAAACCTTTG GCTACACAAT TGGAAGTCTA 1800
AGAACCCATG GAAAAATGCC ATCAAATGAA TAATGCCTTT GTAACCACAA CTTTCACTAT 1860
AATGTGAAAT GTAACTGTCC GTAGTATCAG AGATGTCCAT TTTTACAAGT TATAGTACTA 1920
GAGATATTTT GTAAAATGTA TTATGTCCTG TGAGATGTGT ATCAGTGTTT ATGTGCTATT 1980
AATATTTGTT TAGTTCAGCC AAACTGAAAG GTAGACTTTT ATGAGAACAA TGGACAAGCA 2040
GTGGATACGT GTCAATGTGT GCACTTTTTT TCTATATTAT TGCCCATGAT ATAACTTTAG 2100 AAATAAACCT TAATATTTCT TCCCAAAAAA AAAAA
Protein sequence 5
Gene name: cannabinoid receptor 1 (brain)
Unigene number: Hs.75110
Protein Accession #: NP_001831
Signal sequence : none ound
Pfam domain: 7tm_l [133-397]
Transmembrane domains: 121-143, 156-178, 195-217, 237-259, 276-298, 344-366, 378-400
Cellular Localization: plasma membrane
1 11 21 31 41 51 I I I I I I
MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL TSFRGSPFQE 60
KMTAGDNPQL VPADQVNITE FYNKSLSSFK ENEENIQCGE NFMDIECFMV LNPSQQLAIA 120
VLSLTLGTFT VLENLLVLCV ILHSRSLRCR PSYHFIGSLA VADLLGSVIF VYSFIDFHVF 180
HRKDSRNVFL FKLGGVTASF TASVGSLFLT AIDRYISIHR PLAYKRIVTR PKAWAFCLM 240 T1AIVIAVL PLLG NCEKL QSVCSDIFPH IDETYLMF I GVTSVLLLFI VYAYMYILWK 300
AHSHAVRMIQ RGTQKSIIIH TSEDGKVQVT RPDQARMDIR LAKTLVLILV VLIICWGPLL 360
AIMVYDVFGK MNKLIKTVFA FCSMLCLLNS TVNPIIYALR SKDLRHAFRS MFPSCEGTAQ 420 PLDNSMGDSD CLHKHANNAA SVHRAAESCI KSTVKIAKVT MSVSTDTSAE AL
DNA sequence 6
Gene name : endothelin receptor type B Unigene number: Hs.82002 Probeset Accession #: D13168 Nucleic Acid Accession #: NM_000115 Coding sequence: 238-1566 1 11 21 31 41 51
G IAGACATTCC GIGTGGGGGAC TICTGGCCAGC CICGAGCAACG TIGGATCCTGA GIAGCACTCCC 60 AGGTAGGCAT TTGCCCCGGT GGGACGCCTT GCCAGAGCAG TGTGTGGCAG GCCCCCGTGG 120
AGGATCAACA CAGTGGCTGA ACACTGGGAA GGAACTGGTA CTTGGAGTCT GGACATCTGA 180
AACTTGGCTC TGAAACTGCG CAGCGGCCAC CGGACGCCTT CTGGAGCAGG TAGCAGCATG 240
CAGCCGCCTC CAAGTCTGTG CGGACGCGCC CTGGTTGCGC TGGTTCTTGC CTGCGGCCTG 300
TCGCGGATCT GGGGAGAGGA GAGAGGCTTC CCGCCTGACA GGGCCACTCC GCTTTTGCAA 360 ACCGCAGAGA TAATGACGCC ACCCACTAAG ACCTTATGGC CCAAGGGTTC CAACGCCAGT 420
CTGGCGCGGT CGTTGGCACC TGCGGAGGTG CCTAAAGGAG ACAGGACGGC AGGATCTCCG 480
CCACGCACCA TCTCCCCTCC CCCGTGCCAA GGACCCATCG AGATCAAGGA GACTTTCAAA 540
TACATCAACA CGGTTGTGTC CTGCCTTGTG TTCGTGCTGG GGATCATCGG GAACTCCACA 600
CTTCTGAGAA TTATCTACAA GAACAAGTGC ATGCGAAACG GTCCCAATAT CTTGATCGCC 660
AGCTTGGCTC TGGGAGACCT GCTGCACATC GTCATTGACA TCCCTATCAA TGTCTACAAG 720
CTGCTGGCAG AGGACTGGCC ATTTGGAGCT GAGATGTGTA AGCTGGTGCC TTTCATACAG 780
AAAGCCTCCG TGGGAATCAC TGTGCTGAGT CTATGTGCTC TGAGTATTGA CAGATATCGA 840
GCTGTTGCTT CTTGGAGTAG AATTAAAGGA ATTGGGGTTC CAAAATGGAC AGCAGTAGAA 900
ATTGTTTTGA TTTGGGTGGT CTCTGTGGTT CTGGCTGTCC CTGAAGCCAT AGGTTTTGAT 960
ATAATTACGA TGGACTACAA AGGAAGTTAT CTGCGAATCT GCTTGCTTCA TCCCGTTCAG 1020
AAGACAGCTT TCATGCAGTT TTACAAGACA GCAAAAGATT GGTGGCTGTT CAGTTTCTAT 1080
TTCTGCTTGC CATTGGCCAT CACTGCATTT TTTTATACAC TAATGACCTG TGAAATGTTG 1140
AGAAAGAAAA GTGGCATGCA GATTGCTTTA AATGATCACC TAAAGCAGAG ACGGGAAGTG 1200
GCCAAAACCG TCTTTTGCCT GGTCCTTGTC TTTGCCCTCT GCTGGCTTCC CCTTCACCTC 1260
AGCAGGATTC TGAAGCTCAC TCTTTATAAT CAGAATGATC CCAATAGATG TGAACTTTTG 1320
AGCTTTCTGT TGGTATTGGA CTATATTGGT ATCAACATGG CTTCACTGAA TTCCTGCATT 1380
AACCCAATTG CTCTGTATTT GGTGAGCAAA AGATTCAAAA ACTGCTTTAA GTCATGCTTA 1440
TGCTGCTGGT GCCAGTCATT TGAAGAAAAA CAGTCCTTGG AGGAAAAGCA GTCGTGCTTA 1500
AAGTTCAAAG CTAATGATCA CGGATATGAC AACTTCCGTT CCAGTAATAA ATACAGCTCA 1560
TCTTGAAAGA AGAACTATTC ACTGTATTTC ATTTTCTTTA TATTGGACCG AAGTCATTAA 1620
AACAAAATGA AACATTTGCC AAAACAAAAC AAAAAACTAT GTATTTGCAC AGCACACTAT 1680
TAAAATATTA AGTGTAATTA TTTTAACACT CACAGCTACA TATGACATTT TATGAGCTGT 1740
TTACGGCATG GAAAGAAAAT CAGTGGGAAT TAAGAAAGCC TCGTCGTGAA AGCACTTAAT 1800
TTTTTACAGT TAGCACTTCA ACATAGCTCT TAACAACTTC CAGGATATTC ACACAACACT 1860
TAGGCTTAAA AATGAGCTCA CTCAGAATTT CTATTCTTTC TAAAAAGAGA TTTATTTTTA 1920
AATCAATGGG ACTCTGATAT AAAGGAAGAA TAAGTCACTG TAAAACAGAA CTTTTAAATG 1980
AAGCTTAAAT TACTCAATTT AAAATTTTAA AATCCTTTAA AACAACTTTT CAATTAATAT 2040
TATCACACTA TTATCAGATT GTAATTAGAT GCAAATGAGA GAGCAGTTTA GTTGTTGCAT 2100
TTTTCGGACA CTGGAAACAT TTAAATGATC AGGAGGGAGT AACAGAAAGA GCAAGGCTGT 2160
TTTTGAAAAT CATTACACTT TCACTAGAAG CCCAAACCTC AGCATTCTGC AATATGTAAC 2220
CAACATGTCA CAAACAAGCA GCATGTAACA GACTGGCACA TGTGCCAGCT GAATTTAAAA 2280
TATAATACTT TTAAAAAGAA AATTATTACA TCCTTTACAT TCAGTTAAGA TCAAACCTCA 2340
CAAAGAGAAA TAGAATGTTT GAAAGGCTAT CCCAAAAGAC TTTTTTGAAT CTGTCATTCA 2400
CATACCCTGT GAAGACAATA CTATCTACAA TTTTTTCAGG ATTATTAAAA TCTTCTTTTT 2460
TCACTATCGT AGCTTAAACT CTGTTTGGTT TTGTCATCTG TAAATACTTA CCTACATACA 2520
CTGCATGTAG ATGATTAAAT GAGGGCAGGC CCTGTGCTCA TAGCTTTACG ATGGAGAGAT 2580
GCCAGTGACC TCATAATAAA GACTGTGAAC TGCCTGGTGC AGTGTCCACA TGACAAAGGG 2640
GCAGGTAGCA CCCTCTCTCA CCCATGCTGT GGTTAAAATG GTTTCTAGCA TATGTATAAT 2700
GCTATAGTTA AAATACTATT TTTCAAAATC ATACAGATTA GTACATTTAA CAGCTACCTG 2760 TAAAGCTTAT TACTAATTTT TGTATTATTT TTGTAAATAG CCAATAGAAA AGTTTGCTTG 2820
ACATGGTGCT TTTCTTTCAT CTAGAGGCAA AACTGCTTTT TGAGACCGTA AGAACCTCTT 2880
AGCTTTGTGC GTTCCTGCCT AATTTTTATA TCTTCTAAGC AAAGTGCCTT AGGATAGCTT 2940
GGGATGAGAT GTGTGTGAAA GTATGTACAA GAGAAAACGG AAGAGAGAGG AAATGAGGTG 3000
GGGTTGGAGG AAACCCATGG GGACAGATTC CCATTCTTAG CCTAACGTTC GTCATTGCCT 3060 CGTCACATCA ATGCAAAAGG TCCTGATTTT GTTCCAGCAA AACACAGTGC AATGTTCTCA 3120
GAGTGACTTT CGAAATAAAT TGGGCCCAAG AGCTTTAACT CGGTCTTAAA ATATGCCCAA 3180
ATTTTTACTT TGTTTTTCTT TTAATAGGCT GGGCCACATG TTGGAAATAA GCTAGTAATG 3240
TTGTTTTCTG TCAATATTGA ATGTGATGGT ACAGTAAACC AAAACCCAAC AATGTGGCCA 3300
GAAAGAAAGA GCAATAATAA TTAATTCACA CACCATATGG ATTCTATTTA TAAATCACCC 3360 ACAAACTTGT TCTTTAATTT CATCCCAATC ACTTTTTCAG AGGCCTGTTA TCATAGAAGT 3420
CATTTTAGAC TCTCAATTTT AAATTAATTT TGAATCACTA ATATTTTCAC AGTTTATTAA 3480
TATATTTAAT TTCTATTTAA ATTTTAGATT ATTTTTATTA CCATGTACTG AATTTTTACA 3540
TCCTGATACC CTTTCCTTCT CCATGTCAGT ATCATGTTCT CTAATTATCT TGCCAAATTT 3600
TGAAACTACA CACAAAAAGC ATACTTGCAT TATTTATAAT AAAATTGCAT TCAGTGGCTT 3660 TTTAAAAAAA ATGTTTGATT CAAAACTTTA ACATACTGAT AAGTAAGAAA CAATTATAAT 3720
TTCTTTACAT ACTCAAAACC AAGATAGAAA AAGGTGCTAT CGTTCAACTT CAAAACATGT 3780
TTCCTAGTAT TAAGGACTTT AATATAGCAA CAGACAAAAT TATTGTTAAC ATGGATGTTA 3840
CAGCTCAAAA GATTTATAAA AGATTTTAAC CTATTTTCTC CCTTATTATC CACTGCTAAT 3900
GTGGATGTAT GTTCAAACAC CTTTTAGTAT TGATAGCTTA CATATGGCCA AAGGAATACA 3960 GTTTATAGCA AAACATGGGT ATGCTGTAGC TAACTTTATA AAAGTGTAAT ATAACAATGT 4020
AAAAAATTAT ATATCTGGGA GGATTTTTTG GTTGCCTAAA GTGGCTATAG TTACTGATTT 4080
TTTATTATGT AAGCAAAACC AATAAAAATT TAAGTTTTTT TAACAACTAC CTTATTTTTC 4140
ACTGTACAGA CACTAATTCA TTAAATACTA ATTGATTGTT TAAAAGAAAT ATAAATGTGA 4200 CAAGTGGACA TTATTTATGT TAAATATACA ATTATCAAGC AAGTATGAAG TTATTCAATT 4260
AAAATGCCAC ATTTCTGGTC TCTGGG
Protein sequence 6
Gene name : endothelin receptor type B Unigene number: Hs.82002
Protein Accession #: NP_000106
Signal sequence: 1-27
Pfam domain: 7tm_l [118-386]
Transmembrane domains: 100-122, 138-160, 173-195, 221-243, 277-299, 325-347, 358-380
Cellular Localization: plasma membrane
1 11 21 31 41 51
I I I I I I
MQPPPSLCGR ALVALVLACG LSRI GEERG FPPDRATPLL QTAEIMTPPT KTLWPKGSNA 60
SLARSLAPAE VPKGDRTAGS PPRTISPPPC QGPIEIKETF KYINTWSCL VFVLGIIGNS 120
TLLRIIYKNK CMRNGPNILI ASLALGDLLH IVIDIPINVY KLLAEDWPFG AEMCKLVPF1 180
QKASVGITVL SLCALSIDRY RAVASWSRIK GIGVPKWTAV EIVLIWWSV VLAVPEAIGF 240
DIITMDYKGS YLRICLLHPV QKTAFMQFYK TAKDWWLFSF YFCLPLAITA FFYTLMTCEM 300
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY NQNDPNRCEL 360
LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC LCCWCQSFEE KQSLEEKQSC 420 LKFKANDHGY DNFRSSNKYS SS
DNA sequence 7
Gene name: G protein-coupled receptor 34
Unigene number: Hs.29202
Probeset Accession #: N54926
Nucleic Acid Accession #: AF039686
Coding sequence: 79-1224
1 11 21 31 41 51 l l l l l !
AAAAACCTGA AGACATAAGA ACTACACATG AGGAATATGT CATTTAGCAC TTTCACTTTT 60
TGATCTCCAC AGAAGACAAT GAGAAGTCAT ACCATAACAA TGACGACAAC TTCAGTCAGC 120
AGCTGGCCTT ACTCCTCCCA CAGAATGCGC TTTATAACCA ATCATAGCGA CCAACCGCCA 180
CAAAACTTCT CAGCAACACC AAATGTTACT ACCTGTCCCA TGGATGAAAA ATTGCTATCT 240
ACTGTGTTAA CCACATCCTA CTCTGTTATT TTCATCGTGG GACTGGTTGG GAACATAATC 300
GCCCTCTATG TATTTCTGGG TATTCACCGT AAAAGAAATT CCATTCAAAT TTATCTACTT 360
AACGTAGCCA TTGCAGACCT CCTACTCATC TTCTGCCTCC CTTTCCGAAT CATGTATCAT 420
ATTAACCAAA ACAAGTGGAC ACTAGGTGTG ATTCTGTGCA AGGTTGTGGG AACACTGTTT 480
TATATGAACA TGTACATTAG CATTATTTTG CTTGGATTCA TCAGTTTGGA TCGCTATATA 540
AAAATTAATC GGTCTATACA GCAACGGAAG GCAATAACAA CCAAACAAAG TATTTATGTC 600
TGTTGTATAG TATGGATGGT TGCTCTTGGT GGATTCCTAA CTATGATTAT TTTAACACTT 660
AAGAAAGGAG GGCATAATTC CACAATGTGT TTCCATTACA GAGATAAGCA TAACGCAAAA 720
GGAGAAGCCA TTTTTAACTT CATTCTTGTG GTAATGTTCT GGCTAATTTT CTTACTAATA 780
ATCCTTTCAT ATATTAAGAT TGGGAAGAAT CTATTGAGGA TTTCTAAAAG GAGGTCAAAA 840
TTTCCTAATT CTGGTAAATA TGCCACTACA GCTCGTAACT CCTTTATTGT ACTTATCATT 900
TTTACTATAT GTTTTGTTCC CTATCATGCC TTTCGATTCA TCTACATTTC TTCACAGCTA 960
AATGTATCAT CTTGCTACTG GAAAGAAATT GTTCACAAAA CCAATGAGAT CATGCTGGTT 1020
CTCTCATCTT TCAATAGTTG CTTAGATCCA GTCATGTATT TCCTGATGTC CAGTAACATT 1080
CGCAAAATAA TGTGCCAACT TCTTTTTAGA CGATTTCAAG GTGAACCAAG TAGGAGTGAA 1140
AGCACTTCAG AATTTAAACC AGGATACTCC CTGCATGATA CATCTGTGGC AGTGAAAATA 1200
CAGTCTAGTT CTAAAAGTAC TTGAGGTAAA CATACTAAAA TGAATTATAT AATGCAGCCT 1260
CTTAATTCTT TGAAGAACTA AAAAATTAGG AAACAAAGTT CTAGCATTTA CAAAACTCAG 1320 ATCTCAAAGC TCTGCTTGTA TTTGTGATAT TTCATTTGCT TAACTGTAAA CCAT
Protein sequence 7
Gene name: G protein-coupled receptor 34
Unigene number: Hs.29202
Protein Accession #: AAD50531
Signal sequence : none ound
Pfam domain: 7tm_l [71-327]
Transmembrane domains: 90-112, 126-148, 171-193, 217-239, 263-285
Cellular Localization: plasma membrane
1 11 21 31 41 51
I I I I I I
MRSHTITMTT TSVSSWPYSS HRMRFITNHS DQPPQNFSAT PNVTTCPMDE KLLSTVLTTS 60
YSVIFIVGLV GNIIALYVFL GIHRKRNSIQ IYLLNVAIAD LLLIFCLPFR IMYHINQNK 120
TLGVILCKW GTLFYMNMYI SIILLGFISL DRYIKINRSI QQRKA1TTKQ SIYVCCIVM 180
VALGGFLTMI ILTLKKGGHN STMCFHYRDK HNAKGEAIFN FILWMF LI FLLIILSYIK 240
IGKNLLRISK RRSKFPNSGK YATTARNSFI VLIIFTICFV PYHAFRFIYI SSQLNVSSCY 300
BKEIVHKTNE IMLVLSSFNS CLDPVMYFLM SSNIRKIMCQ LLFRRFQGEP SRSESTSEFK 360 PGYSLHDTSV AVKIQSSSKS T
DNA SEQUENCE 8
Gene name: exostoses (multiple) -like 2
Unigene number: Hs.61152
Nucleic Acid Accession #: NM_001439
Coding sequence: 288-1280
1 11 21 31 41 51
I I I I I I
CACTTTGCGG GCGGCACTTT TTCCAGGTTG TTAATCCAGC TAATGGAGAA GGATAGATGC 60 ACGCTACTTG GTTTAGAAAA AAAAACAAAA ATGAGCAAAC GAGACGCCCC TTCCGTTTTA 120
TGATAACTAA GCTGCAGGGA AATAAATCGG CTGGCCCTAC TGCAATCTAC TGCACTCGAG 180
AAACATCACA GAAAATTCTT TGATTTATCT TAATAGTGAC AAGTGAGCCT GCTTCTGTCA 240
ATTACTGAAG CTATAAGGAG ATTTTTTAAA AATTAAACTT CAACACAATG AGGTGTTGCC 300
ACATCTGCAA ACTTCCTGGG AGAGTAATGG GGATTCGAGT GCTTCGATTA TCTTTGGTGG 360
TCATCCTCGT ATTATTACTG GTAGCTGGTG CTTTGACTGC CTTACTTCCC AGTGTTAAAG 420
AAGACAAGAT GCTCATGTTG CGTAGGGAAA TAAAATCCCA GGGCAAGTCC ACCATGGACT 480
CCTTTACTCT CATAATGCAG ACGTACAACA GAACAGATCT CTTATTGAAA CTTTTAAATC 540
ATTATCAGGC TGTACCAAAT CTGCACAAAG TGATTGTGGT ATGGAACAAT ATTGGAGAGA 600
AGGCACCAGA TGAATTATGG AATTCTCTAG GGCCCCACCC TATCCCTGTG ATCTTCAAAC 660
AACAGACAGC AAACAGGATG AGAAATCGAC TCCAGGTCTT TC'CTGAACTG GAAACCAATG 720
CAGTGTTGAT GGTAGATGAT GACACACTCA TCAGCACCCC AGACCTTGTT TTTGCTTTCT 780
CAGTTTGGCA GCAATTTCCT GATCAAATTG TAGGATTTGT TCCTAGAAAG CACGTCTCTA 840
CTTCATCAGG TATCTACAGT TATGGAAGTT TTGAAATGCA AGCACCAGGG TCTGGAAATG 900
GTGACCAGTA CTCTATGGTG CTGATTGGAG CCTCATTCTT CAATAGCAAA TATCTTGAAT 960
TATTTCAGAG GCAACCTGCA GCTGTCCATG CTTTGATAGA TGATACTCAA AACTGTGATG 1020
ATATTGCCAT GAATTTTATC ATTGCCAAGC ATATTGGCAA GACTTCAGGG ATATTTGTGA 1080
AGCCTGTAAA CATGGACAAT TTGGAAAAAG AAACCAACAG TGGCTATTCT GGAATGTGGC 1140
ATCGAGCTGA GCACGCTCTG CAGAGGTCTT ATTGTATAAA TAAGCTTGTT AATATCTATG 1200
ATAGCATGCC CTTAAGATAC TCCAACATTA TGATTTCCCA GTTTGGTTTT CCATATGCCA 1260
ACTACAAAAG AAAAATATAA AAGTAAAACA AACAAAAACA AACCTGAAAA CTGCTTGGCA 1320
TTTGAGTAGC TTCTCCATGC TATGTATTTT TTTAAGCAAC ATCATGAATT TTATCTACTC 1380
CAGAAGTCTC TACAATAGAA AAAAAAGTGC AGTGCTTCTA GGATATAAAA TTCACATTAC 1440
TTTTGAAAGC CAAGAAGTTG GTCTTATCCA GTTAGGTCTT CTTATGAAGA GTTTTCATCC 1500
AGGGATATAA CTCCTTGGTC AGTGATTTTA TTGTTTACAT CCTGAGACTG TTCTACAGTT 1560
TCTTTGACTC CTGGCATTTG CCTTAAGGAC CTATAGCAAG CTGTTTCTAG GATCAGAAAC 1620
TCAAGAGAGG CATTTCTCTG CTTTTTCACT AAAGGTCAGT TGTTTTAATT TGAAACCTGA 1680
AATGCCTCTT TAGCAAAGCC TGTGGTATGG GGTAAAGCCA TGTAAGAAGA GAATAGTCTC 1740
AGTCACATAT GAAGAGGAAA ATTTGCAGCT GCCAGTGCTT TCCTTGTGGC CCTGCCAACC 1800
AGCTCTTCCA GGACGAACTC AGTCCAGCAT GGTTTTGATβ TAACCATCCA TGCTTTTATT 1860
TTTGTTAAGT CTTTTGTGAC TGGGACAGTT AATTTTAGTA GCTGAAGAAC GTCTAGTTGT 1920
TTGCTTGATA TTTGTGAACA TTTACTGCAT GGATCACAAA ACAATATACC CTGTATTTCT 1980
TACACGCCAC TTATATGCAG CAAGGAGTAA ATGTGTTACT AGATTCGGGT AGTGCATTTT 2040
GTCACTGAAT CTGACCTTGA GAATGTACAT TAATTCTTAT ATTTTACATA ATGTATGTGT 2100
TGTTTAAGAA ATGTATAAAA AACCTGAAAA AAATGAGTAA GAACTGGCAG AAGTTAAAAC 2160
CCTTTGTATC AAAAGATCTT TATTGGTAGA GCACTGGTTA TCTTCTGGAT ACTAAAAAGT 2220
TGTATTACAA AGCCAAACAC TTGCATTCAC AACTTTAAAA AAAGATCCAA GGAACTATTC 2280
ATAATGATGA AATTTCAACT ACATACAAGG AGGAGAAAAT AAGAACCCAG TCATAACAGA 2340
GGAATTCTAT AGGAGTCTGC ATCAATTCAT TCTTAAGGTT GCCTACTCTC TGTTATGTGA 2400
ATTAGCGTCT GTGTTTCACC CATTGTCTGT GTTTAGTCCT TGTTCACCAC TAAGGCAAGG 2460
AATTCTTAAC TAGGCCTCTG TTTACCAACT TCTCTTTCTC CTCCTTTCCC TCTTATTCCT 2520
CCTTCTCCTC TTCCTTCTTA TATAATGCTA GTATATTCTC AAAATTGCAA AGCTGTOAGA 2580
ATATTAAAAT AATCATGGCT AATGTTCCAA TAATGAGGTC TTTGTGCATT TAGTTCCGCA 2640
TATGATGGTT TTTTTTTTAC ATTAAAGAGT ATATGTGTCT TAATGCAGTC AGATTGTAAA 2700
AAACAAAAAC AAAGAAACTA AGAATCTTAC TAAAAATCGA TAATGTCAGT TATCTGTTTT 2760
GTCCAATATT GGTAGTACTT TTTTGCCTCT TATGATTCCT CTAGCAGATA AATAAAAGAA 2820
ACTTTTGCCA TCC
Protein sequence 8
Gene name: exostoses (multiple) -like 2 Unigene number: Hs.61152 Protein Accession #: NP_001430 Signal sequence: 1-38 Transmembrane domains : none found Cellular Localization: plasma membrane 1 11 21 31 41 51
I I MlRCCHICKLP GlRVMGIRVLR LlSLWILVLL LlVAGALTALL PSVKEDKMLM LRREIKSQGK 60 STMDSFTLIM QTYNRTDLLL KLLNHYQAVP NLHKVIWN NIGEKAPDEL NSLGPHPIP 120 VIFKQQTANR MRNRLQVFPE LETNAVLMVD DDTLISTPDL VFAFSVWQQF PDQIVGFVPR 180 KHVSTSSGIY SYGSFEMQAP GSGNGDQYSM VLIGASFFNS KYLELFQRQP AAVHALIDDT 240 QNCDDIAMNF IIAKHIGKTS GIFVKPVNMD NLEKETNSGY SGMWHRAEHA LQRSYCINKL 300 VNIYDSMPLR YSNIMISQFG FPYANYKRKI
DNA SEQUENCE 9
Gene name: Homo sapiens growth differentiation factor 1 (GDF1)
Unigene number: Hs.92614
Probeset Accession #: AL120193
Nucleic Acid Accession #: NM_021267
Coding sequence: 73-1125
1 11 21 31 51 l l l l
ACGCGGGGCG CGCGGCTCCG TCGGCTACCG CGGGCGGGCG CAGGCGACGG GCACGGCGGG 60 CGAGCGGGCG GTATGGCGGC GGCGGGGCCC GCGGCGGGGC CGACGGGGCC CGAGCCCATG 120 CCGAGCTACG CGCAGCTAGT GCAGCGCGGC TGGGGCAGCG CGCTGGCGGC GGCGCGGGGC 180 TGCACGGACT GCGGCTGGGG GCTGGCGCGT CGCGGCCTGG CTGAGCACGC GCACCTGGCG 240 CCGCCCGAGC TGCTGCTGCT GGCGCTCGGC GCGCTGGGCT GGACCGCGCT GCGCTCCGCG 300 GCCACTGCGC GCCTCTTTCG GCCCCTGGCG AAGCGGTGCT GCCTCCAGCC CAGAGATGCC 360 GCCAAGATGC CCGAGAGCGC TTGGAAGTTT CTCTTCTACC TGGGCAGCTG GAGCTACAGT 420 GCCTACCTGC TGTTTGGCAC CGACTACCCC TTCTTCCATG ACCCACCATC TGTCTTCTAC 480 GACTGGACGC CGGGCATGGC AGTGCCACGG GACATTGCAG CCGCCTACCT GCTCCAGGGA 540 AGCTTCTATG GCCACTCCAT CTACGCTACG CTATACATGG ACACCTGGCG CAAGGACTCG 600 GTGGTCATGC TGCTCCACCA CGTGGTCACT CTCATCCTCA TCGTCTCCTC CTACGCCTTC 660 CGGTACCACA ATGTGGGCAT CCTTGTGCTC TTCCTGCACG ATATCAGTGA CGTGCAGCTT 720 GAGTTCACCA AGCTCAACAT TTACTTCAAG TCCCGCGGCG GCTCCTACCA TCGGCTGCAT 780 GCCTTGGCAG CAGACTTGGG CTGCCTCAGC TTCGGCTTCA GCTGGTTCTG GTTCCGCCTC 840 TACTGGTTCC CGCTCAAGGT CCTGTATGCC ACCAGTCACT GCAGTCTGCG CACGGTGCCT 900 GACATCCCCT TCTACTTCTT CTTCAATGCG CTCCTGCTGC TGCTCACCCT TATGAACCTC 960 TACTGGTTCC TGTACATCGT GGCGTTTGCA GCCAAGGTGT TGACAGGCCA GGTGCACGAG 1020 CTGAAGGACC TGCGGGAGTA TGACACAGCC GAGGCCCAGA GCCTGAAGCC CAGCAAAGCC 1080 GAGAAGCCAC TGAGGAACGG CCTGGTGAAG GACAAGCGCT TCTGAACCCC TCGGCCCCGC 1140 CCCCGTGGAC CCGGCCCCAC CCCGAATACC CCGGCCACGC TCCCCGTCCT TGGCCGCCCC 1200 TCCACCCCCT CCAACTCTGC TCCTCTAGGG CCGCCGCCAC CTCCCCTGGG ACCCCGCCCC 1260 CTCATCCTGC CTCCATTTCC CGGCCACGCC CCCCAGGACC CCTGCCCCTC CGGGGACACC 1320 GGCCCCGCCC TCAGCCCACT GGTCCCGGGC CGCCGCGGAC CCTGCGCACT CTCTGGTCAT 1380 CGCCTGGGAG GAAGATGCCA CCGCCGCAGC AAGGTCCCTG CGGCCACCAC CTCCTCCTCC 1440 TCCTGGCCCT GCTGCTGCCC TCGCTGCCCC TGACCCGCGC CCCCGTGCCC CCAGGCCCAG 1500 CCGCCGCCCT GCTCCAGGCT CTAGGACTGC GCGATGAGCC CCAGGGTGCC CCCAGGCTCC 1560 GGCCGGTTCC CCCGGTCATG TGGCGCCTGT TTCGACGCCG GGACCCCCAG GAGACCAGGT 1620 CTGGCTCGCG GCGGACGTCC CCAGGGGTCA CCCTGCAACC GTGCCACGTG GAGGAGCTGG 1680 GGGTCGCCGG AAACATCGTG CGCCACATCC CGGACCGCGG TGCGCCCACC CGGGCCTCGG 1740 AGCCTGTCTC GGCCGCGGGG CATTGCCCTG AGTGGACAGT CGTCTTCGAC CTGTCGGCTG 1800 TGGAACCCGC TGAGCGCCCG AGCCGGGCCC GCCTGGAGCT GCGTTTCGCG GCGGCGGCGG 1860 CGGCAGCCCC GGAGGGCGGC TGGGAGCTGA GCGTGGCGCA AGCGGGCCAG GGCGCGGGCG 1920 CGGACCCCGG GCCGGTGCTG CTCCGCCAGT TGGTGCCCGC CCTGGGGCCG CCAGTGCGCG 1980 CGGAGCTGCT GGGCGCCGCT TGGGCTCGCA ACGCCTCATG GCCGCGCAGC CTCCGCCTGG 2040 CGCTGGCGCT ACGCCCCCGG GCCCCTGCCG CCTGCGCGCG CCTGGCCGAG GCCTCGCTGC 2100 TGCTGGTGAC CCTCGACCCG CGCCTGTGCC ACCCCCTGGC CCGGCCGCGG CGCGACGCCG 2160 AACCCGTGTT GGGCGGCGGC CCCGGGGGCG CTTGTCGCGC GCGGCGGCTG TACGTGAGCT 2220 TCCGCGAGGT GGGCTGGCAC CGCTGGGTCA TCGCGCCGCG CGGCTTCCTG GCCAACTACT 2280 GCCAGGGTCA GTGCGCGCTG CCCGTCGCGC TGTCGGGGTC CGGGGGGCCG CCGGCGCTCA 2340 ACCACGCTGT GCTGCGCGCG CTCATGCACG CGGCCGCCCC GGGAGCCGCC GACCTGCCCT 2400 GCTGCGTGCC CGCGCGCCTG TCGCCCATCT CCGTGCTCTT CTTTGACAAC AGCGACAACG 2460 TGGTGCTGCG GCAGTATGAG GACATGGTGG TGGACGAGTG CGGCTGCCGC TAACCCGGGG
Protein sequence 9
Gene name: Homo sapiens growth differentiation factor 1 (GDF1)
Unigene number: Hs.92614
Protein Accession #: NP_067090
Signal sequence : none found
Transmembrane domains: 106-128, 148-169, 184-206, 244- 266, 285-307
Cellular Localization, plasma membrane
1 11 21 31 41 51 MlAAAGPAAGP TlGPEPMPSYA QlLVQRGWGSA LlAAARGCTDC GlWGLARRGLA E IHAHLAPPEL 60 LLLALGALG TALRSAATAR LFRPLAKRCC LQPRDAAKMP ESAWKFLFYL GS SYSAYLL 120 FGTDYPFFHD PPSVFYDWTP GMAVPRDIAA AYLLQGSFYG HSIYATLYMD TWRKDSWML 180 LHHWTLILI VSSYAFRYHN VGILVLFLHD ISDVQLEFTK LNIYFKSRGG SYHRLHALAA 240 DLGCLSFGFS WF FRLYWFP LKVLYATSHC SLRTVPDIPF YFFFNALLLL LTLMNLY FL 300 YIVAFAAKVL TGQVHELKDL REYDTAEAQS LKPSKAEKPL RNGLVKDKRF
DNA SEQUENCE 10
Gene name: epidermal growth factor receptor (avian erythroblastic leukemia
Unigene number: Hs.77432
Nucleic Acid Accession # : NM_005228
Coding sequence: 187-3819
1 11 21 31 41 51
G ICCGCGCTGC GICCGGAGTCC CIGAGCTAGCC CICGGCGCCGC CIGCCGCCCAG AICCGGACGAC 60 AGGCCACCTC GTCGGCGTCC GCCCGAGTCC CCGCCTCGCC GCCAACGCCA CAACCACCGC 120 GCACGGCCCC CTGACTCCGT CCAGTATTGA TCGGGAGAGC CGGAGCGAGC TCTTCGGGGA 180 GCAGCGATGC GACCCTCCGG GACGGCCGGG GCAGCGCTCC TGGCGCTGCT GGCTGCGCTC 240 TGCCCGGCGA GTCGGGCTCT GGAGGAAAAG AAAGTTTGCC AAGGCACGAG TAACAAGCTC 300 ACGCAGTTGG GCACTTTTGA AGATCATTTT CTCAGCCTCC AGAGGATGTT CAATAACTGT 360 GAGGTGGTCC TTGGGAATTT GGAAATTACC TATGTGCAGA GGAATTATGA TCTTTCCTTC 420 TTAAAGACCA TCCAGGAGGT GGCTGGTTAT GTCCTCATTG CCCTCAACAC AGTGGAGCGA 480 ATTCCTTTGG AAAACCTGCA GATCATCAGA GGAAATATGT ACTACGAAAA TTCCTATGCC 540 TTAGCAGTCT TATCTAACTA TGATGCAAAT AAAACCGGAC TGAAGGAGCT GCCCATGAGA 600 AATTTACAGG AAATCCTGCA TGGCGCCGTG CGGTTCAGCA ACAACCCTGC CCTGTGCAAC 660 GTGGAGAGCA TCCAGTGGCG GGACATAGTC AGCAGTGACT TTCTCAGCAA CATGTCGATG 720 GACTTCCAGA ACCACCTGGG CAGCTGCCAA AAGTGTGATC CAAGCTGTCC CAATGGGAGC 780 TGCTGGGGTG CAGGAGAGGA GAACTGCCAG AAACTGACCA AAATCATCTG TGCCCAGCAG 840 TGCTCCGGGC GCTGCCGTGG CAAGTCCCCC AGTGACTGCT GCCACAACCA GTGTGCTGCA 900 GGCTGCACAG GCCCCCGGGA GAGCGACTGC CTGGTCTGCC GCAAATTCCG AGACGAAGCC 960 ACGTGCAAGG ACACCTGCCC CCCACTCATG CTCTACAACC CCACCACGTA CCAGATGGAT 1020 GTGAACCCCG AGGGCAAATA CAGCTTTGGT GCCACCTGCG TGAAGAAGTG TCCCCGTAAT 1080 TATGTGGTGA CAGATCACGG CTCGTGCGTC CGAGCCTGTG GGGCCGACAG CTATGAGATG 1140 GAGGAAGACG GCGTCCGCAA GTGTAAGAAG TGCGAAGGGC CTTGCCGCAA AGTGTGTAAC 1200 GGAATAGGTA TTGGTGAATT TAAAGACTCA CTCTCCATAA ATGCTACGAA TATTAAACAC 1260 TTCAAAAACT GCACCTCCAT CAGTGGCGAT CTCCACATCC TGCCGGTGGC ATTTAGGGGT 1320 GACTCCTTCA CACATACTCC TCCTCTGGAT CCACAGGAAC TGGATATTCT GAAAACCGTA 1380 AAGGAAATCA CAGGGTTTTT GCTGATTCAG GCTTGGCCTG AAAACAGGAC GGACCTCCAT 1440 GCCTTTGAGA ACCTAGAAAT CATACGCGGC AGGACCAAGC AACATGGTCA GTTTTCTCTT 1500 GCAGTCGTCA GCCTGAACAT AACATCCTTG GGATTACGCT CCCTCAAGGA GATAAGTGAT 1560 GGAGATGTGA TAATTTCAGG AAACAAAAAT TTGTGCTATG CAAATACAAT AAACTGGAAA 1620 AAACTGTTTG GGACCTCCGG TCAGAAAACC AAAATTATAA GCAACAGAGG TGAAAACAGC 1680 TGCAAGGCCA CAGGCCAGGT CTGCCATGCC TTGTGCTCCC CCGAGGGCTG CTGGGGCCCG 1740 GAGCCCAGGG ACTGCGTCTC TTGCCGGAAT GTCAGCCGAG GCAGGGAATG CGTGGACAAG 1800 TGCAAGCTTC TGGAGGGTGA GCCAAGGGAG TTTGTGGAGA ACTCTGAGTG CATACAGTGC 1860
CACCCAGAGT GCCTGCCTCA GGCCATGAAC ATCACCTGCA CAGGACGGGG ACCAGACAAC 1920
TGTATCCAGT GTGCCCACTA CATTGACGGC CCCCACTGCG TCAAGACCTG CCCGGCAGGA 1980
GTCATGGGAG AAAACAACAC CCTGGTCTGG AAGTACGCAG ACGCCGGCCA TGTGTGCCAC 2040
CTGTGCCATC CAAACTGCAC CTACGGATGC ACTGGGCCAG GTCTTGAAGG CTGTCCAACG 2100
AATGGGCCTA AGATCCCGTC CATCGCCACT GGGATGGTGG GGGCCCTCCT CTTGCTGCTG 2160
GTGGTGGCCC TGGGGATCGG CCTCTTCATG CGAAGGCGCC ACATCGTTCG GAAGCGCACG 2220
CTGCGGAGGC TGCTGCAGGA GAGGGAGCTT GTGGAGCCTC TTACACCCAG TGGAGAAGCT 2280
CCCAACCAAG CTCTCTTGAG GATCTTGAAG GAAACTGAAT TCAAAAAGAT CAAAGTGCTG 2340
GGCTCCGGTG CGTTCGGCAC GGTGTATAAG GGACTCTGGA TCCCAGAAGG TGAGAAAGTT 2400
AAAATTCCCG TCGCTATCAA GGAATTAAGA GAAGCAACAT CTCCGAAAGC CAACAAGGAA 2460
ATCCTCGATG AAGCCTACGT GATGGCCAGC GTGGACAACC CCCACGTGTG CCGCCTGCTG 2520
GGCATCTGCC TCACCTCCAC CGTGCAACTC ATCACGCAGC TCATGCCCTT CGGCTGCCTC 2580
CTGGACTATG TCCGGGAACA CAAAGACAAT ATTGGCTCCC AGTACCTGCT CAACTGGTGT 2640
GTGCAGATGG CAAAGGGCAT GAACTACTTG GAGGACCGTC GCTTGGTGCA CCGCGACCTG 2700
GCAGCCAGGA ACGTACTGGT GAAAACACCG CAGCATGTCA AGATCACAGA TTTTGGGCTG 2760
GCCAAACTGC TGGGTGCGGA AGAGAAAGAA TACCATGCAG AAGGAGGCAA AGTGCCTATC 2820
AAGTGGATGG CATTGGAATC AATTTTACAC AGAATCTATA CCCACCAGAG TGATGTCTGG 2880
AGCTACGGGG TGACCGTTTG GGAGTTGATG ACCTTTGGAT CCAAGCCATA TGACGGAATC 2940
CCTGCCAGCG AGATCTCCTC CATCCTGGAG AAAGGAGAAC GCCTCCCTCA GCCACCCATA 3000
TGTACCATCG ATGTCTACAT GATCATGGTC AAGTGCTGGA TGATAGACGC AGATAGTCGC 3060
CCAAAGTTCC GTGAGTTGAT CATCGAATTC TCCAAAATGG CCCGAGACCC CCAGCGCTAC 3120
CTTGTCATTC AGGGGGATGA AAGAATGCAT TTGCCAAGTC CTACAGACTC CAACTTCTAC 3180
CGTGCCCTGA TGGATGAAGA AGACATGGAC GACGTGGTGG ATGCCGACGA GTACCTCATC 3240
CCACAGCAGG GCTTCTTCAG CAGCCCCTCC ACGTCACGGA CTCCCCTCCT GAGCTCTCTG 3300
AGTGCAACCA GCAACAATTC CACCGTGGCT TGCATTGATA GAAATGGGCT GCAAAGCTGT 3360
CCCATCAAGG AAGACAGCTT CTTGCAGCGA TACAGCTCAG ACCCCACAGG CGCCTTGACT 3420
GAGGACAGCA TAGACGACAC CTTCCTCCCA GTGCCTGAAT ACATAAACCA GTCCGTTCCC 3480
AAAAGGCCCG CTGGCTCTGT GCAGAATCCT GTCTATCACA ATCAGCCTCT GAACCCCGCG 3540
CCCAGCAGAG ACCCACACTA CCAGGACCCC CACAGCACTG CAGTGGGCAA CCCCGAGTAT 3600
CTCAACACTG TCCAGCCCAC CTGTGTCAAC AGCACATTCG ACAGCCCTGC CCACTGGGCC 3660
CAGAAAGGCA GCCACCAAAT TAGCCTGGAC AACCCTGACT ACCAGCAGGA CTTCTTTCCC 3720
AAGGAAGCCA AGCCAAATGG CATCTTTAAG GGCTCCACAG CTGAAAATGC AGAATACCTA 3780
AGGGTCGCGC CACAAAGCAG TGAATTTATT GGAGCATGAC CACGGAGGAT AGTATGAGCC 3840
CTAAAAATCC AGACTCTTTC GATACCCAGG ACCAAGCCAC AGCAGGTCCT CCATCCCAAC 3900
AGCCATGCCC GCATTAGCTC TTAGACCCAC AGACTGGTTT TGCAACGTTT ACACCGACTA 3960
GCCAGGAAGT ACTTCCACCT CGGGCACATT TTGGGAAGTT GCATTCCTTT GTCTTCAAAC 4020
TGTGAAGCAT TTACAGAAAC GCATCCAGCA AGAATATTGT CCCTTTGAGC AGAAATTTAT 4080
CTTTCAAAGA GGTATATTTG AAAAAAAAAA AAAAAGTATA TGTGAGGATT TTTATTGATT 4140
GGGGATCTTG GAGTTTTTCA TTGTCGCTAT TGATTTTTAC TTCAATGGGC TCTTCCAACA 4200
AGGAAGAAGC TTGCTGGTAG CACTTGCTAC CCTGAGTTCA TCCAGGCCCA ACTGTGAGCA 4260
AGGAGCACAA GCCACAAGTC TTCCAGAGGA TGCTTGATTC CAGTGGTTCT GCTTCAAGGC 4320
TTCCACTGCA AAACACTAAA GATCCAAGAA GGCCTTGATG GCCCCAGCAG GCCGGATCGG 4380
TACTGTATCA AGTCATGGCA GGTACAGTAG GATAAGCCAC TCTGTCCCTT CCTGGGCAAA 4440
GAAGAAACGG AGGGGATGAA TTCTTCCTTA GACTTACTTT TGTAAAAATG TCCCCACGGT 4500
ACTTACTCCC CACTGATGGA CCAGTGGTTT CCAGTCATGA GCGTTAGACT GACTTGTTTG 4560
TCTTCCATTC CATTGTTTTG AAACTCAGTA TGCCGCCCCT GTCTTGCTGT CATGAAATCA 4620
GCAAGAGAGG ATGACACATC AAATAATAAC TCGGATTCCA GCCCACATTG GATTCATCAG 4680
CATTTGGACC AATAGCCCAC AGCTGAGAAT GTGGAATACC TAAGGATAAC ACCGCTTTTG 4740
TTCTCGCAAA AACGTATCTC CTAATTTGAG GCTCAGATGA AATGCATCAG GTCCTTTGGG 4800
GCATAGATCA GAAGACTACA AAAATGAAGC TGCTCTGAAA TCTCCTTTAG CCATCACCCC 4860
AACCCCCCAA AATTAGTTTG TGTTACTTAT GGAAGATAGT TTTCTCCTTT TACTTCACTT 4920
CAAAAGCTTT TTACTCAAAG AGTATATGTT CCCTCCAGGT CAGCTGCCCC CAAACCCCCT 4980
CCTTACGCTT TGTCACACAA AAAGTGTCTC TGCCTTGAGT CATCTATTCA AGCACTTACA 5040
GCTCTGGCCA CAACAGGGCA TTTTACAGGT GCGAATGACA GTAGCATTAT GAGTAGTGTG 5100
AATTCAGGTA GTAAATATGA AACTAGGGTT TGAAATTGAT AATGCTTTCA CAACATTTGC 5160
AGATGTTTTA GAAGGAAAAA AGTTCCTTCC TAAAATAATT TCTCTACAAT TGGAAGATTG 5220
GAAGATTCAG CTAGTTAGGA GCCCATTTTT TCCTAATCTG TGTGTGCCCT GTAACCTGAC 5280
TGGTTAACAG CAGTCCTTTG TAAACAGTGT TTTAAACTCT CCTAGTCAAT ATCCACCCCA 5340
TCCAATTTAT CAAGGAAGAA ATGGTTCAGA AAATATTTTC AGCCTACAGT TATGTTCAGT 5400
CACACACACA TACAAAATGT TCCTTTTGCT TTTAAAGTAA TTTTTGACTC CCAGATCAGT 5460
CAGAGCCCCT ACAGCATTGT TAAGAAAGTA TTTGATTTTT GTCTCAATGA AAATAAAACT 5520
ATATTCATTT CC
Protein sequence 10
Gene name epidermal growth factor receptor (avian erythroblastic leukemia
Unigene number Hs 77432
Protein Accession # NP_005219
Signal sequence 1-27
Pfam domain Recep_L_domam [57-190, 372-492]
Transmembrane domains 646-668
1 11 21 31 41 51
I I I I I I
MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV 60 VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQ1IRGN MYYENSYALA 120 VLSNYDANKT GLKELPMRNL QEILHGAVRF SNNPALCNVE SIQ RDIVSS DFLSNMSMDF 180 QNHLGSCQKC DPSCPNGSC GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC 240 TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 300 VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDSLS INATNIKHFK 360 NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE ITGFLLIQAW PENRTDLHAF 420 ENLEIIRGRT KQHGQFSLAV VSLNITSLGL RSLKEISDGD VIISGNKNLC YANTIN KKL 480 FGTSGQKTKI ISNRGENSCK ATGQVCHALC SPEGCWGPEP RDCVSCRNVS RGRECVDKCK 540 LLEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGVM 600 GENNTLVWKY ADAGHVCHLC HPNCTYGCTG PGLEGCPTNG PKIPSIATGM VGALLLLLW 660 ALGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS 720 GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI 780 CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA 840 RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIK MALESILHRI YTHQSDV SY 900 GVTVWELMTF GSKPYDGIPA SEISSILEKG ERLPQPPICT IDVYMIMVKC MIDADSRPK 960 FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEED DDV VDADEY IPQ 1020 QGFFSSPSTS RTPLLSSLSA TSNNSTVACI DRNGLQSCPI KEDSFLQRYS SDPTGALTED 1080 SIDDTFLPVP EYINQSVPKR PAGSVQNPVY HNQPLNPAPS RDPHYQDPHS TAVGNPEYLN 1140 TVQPTCVNST FDSPAHWAQK GSHQISLDNP DYQQDFFPKE AKPNGIFKGS TAENAEYLRV 1200 APQSSEFIGA
DNA sequence 11
Gene name claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) Unigene number Hs 110903 Probeset Accession # AW245805
Nucleic Acid Accession # NM_003277 Coding sequence 121-777
11 21 31 41 51
I I I I I
AGGGGACTGG GGCCAAGAGC CGGGAGCGCG GGCGCAAAGG CACCAGGGCC CGCCCAGGGC 60 GCCGCGCAGC ACGGCCTTGG GGGTTCTGCG GGCCTTCGGG TGCGCGTCTC GCCTCTAGCC 120 ATGGGGTCCG CAGCGTTGGA GATCCTGGGC CTGGTGCTGT GCCTGGTGGG CTGGGGGGGT 180 CTGATCCTGG CGTGCGGGCT GCCCATGTGG CAGGTGACCG CCTTCCTGGA CCACAACATC 240 GTGACGGCGC AGACCACCTG GAAGGGCCTG TGGATGTCGT GCGTGGTGCA GAGCACCGGG 300 CACATGCAGT GCAAAGTGTA CGACTCGGTG CTGGCTCTGA GCACCGAGGT GCAGGCGGCG 360 CGGGCGCTCA CCGTGAGCGC CGTGCTGCTG GCGTTCGTTG CGCTCTTCGT GACCCTGGCG 420 GGCGCGCAGT GCACCACCTG CGTGGCCCCG GGCCCGGCCA AGGCGCGTGT GGCCCTCACG 480 GGAGGCGTGC TCTACCTGTT TTGCGGGCTG CTGGCGCTCG TGCCACTCTG CTGGTTCGCC 540 AACATTGTCG TCCGCGAGTT TTACGACCCG TCTGTGCCCG TGTCGCAGAA GTACGAGCTG 600 GGCGCAGCGC TGTACATCGG CTGGGCGGCC ACCGCGCTGC TCATGGTAGG CGGCTGCCTC 660 TTGTGCTGCG GCGCCTGGGT CTGCACCGGC CGTCCCGACC TCAGCTTCCC CGTGAAGTAC 720 TCAGCGCCGC GGCGGCCCAC GGCCACCGGC GACTACGACA AGAAGAACTA CGTCTGAGGG 780 CGCTGGGCAC GGCCGGGCCC CTCCTGCCAG CCACGCCTGC GAGGCGTTGG ATAAGCCTGG 840 GGAGGCCCGC ATGGACCGCG GCTTCCGCCG GGTAGCGCGG CGCGCAGGCT CCTCGGAACG 900 TCCGGCTCTG CGCCCCGACG CGGCTCCTGG ATCCGCTCCT GCCTGCGCCC GCAGCTGACC 960 TTCTCCTGCC ACTAGCCCGG CCCTGCCCTT AACAGACGGA ATGAAGTTTC CTTTTCTGTG 1020 CGCGGCGCTG TTTCCATAGG CAGAGCGGGT GTCAGACTGA GGATTTCGCT TCCCCTCCAA 1080 GACGCTGGGG GTCTTGGCTG CTGCCTTACT TCCCAGAGGC TCCTGCTGAC TTCGGAGGGG 1140 CGGATGCAGA GCCCGGGGCC CCCACCGGAA GATGTGTACA GCTGGTCTTT ACTCCATCGG 1200 CAGGCCCGAG CCCAGGGACC AGTGACTTGG CCTGGACCTC CCGGTCTCAC TCCAGCATCT 1260 CCCCAGGCAA GGCTTGTGGG CACCGGAGCT TGAGAGAGGG CGGGAGTGGG AAGGCTAAGA 1320 ATCTGCTTAG
Protein sequence 11
Gene name claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)
Unigene number Hs 110903
Protein Accession # NP_003268
Signal sequence none found
Pfam domain PMP22 Claudin [4-181]
Transmembrane domains 5 27, 74-96, 123 145, 164-186
Cellular Localization plasma membrane
1 11 21 31 41 51
I I I I I I
MGSAALEILG LVLCLVGWGG LILACGLPM QVTAFLDHNI VTAQTT KGL WMSCWQSTG 60 HMQCKVYDSV LALSTEVQAA RALTVSAVLL AFVALFVTLA GAQCTTCVAP GPAKARVALT 120 GGVLYLFCGL LALVPLC FA NIWREFYDP SVPVSQKYEL GAALYIGWAA TALL VGGCL 180 LCCGAWVCTG RPDLSFPVKY SAPRRPTATG DYDKKNYV
DNA sequence 12
Gene name vascular endothelial ]unctιon-as sociated molecule
Unigene number Hs 54650
Probeset Accession # AA410345
Nucleic Acid Accession # AF255910
Coding sequence 241-1137
1 11 21 31 41 51 l l l l 1 1
TTACCATTGT GTTGGGCTGC GAGAAGACGA CAGAAGGGGG ACCCGCCTCT TGGCAGCCAG 60 CTGAGAAGGC GCCCCGGGGA GGGGGAAACT GACATCCCAT CTAGAGCCGT CCCTCCTCTT 120 CCTCCCCTCC CGACTCTCTG CTCCTTTCCC GCCCCAGAAG TTCAAGGGCC CCCGGCCTCC 180 TGCGCTCCTG CCGCCGGGAC CCTCGACCTC CTCAGAGCAG CCGGCTGCCG CCCCGGGAAG 240 ATGGCGAGGA GGAGCCGCCA CCGCCTCCTC CTGCTGCTGC TGCGCTACCT GGTGGTCGCC 300 CTGGGCTATC ATAAGGCCTA TGGGTTTTCT GCCCCAAAAG ACCAACAGGT AGTCACAGCA 360 GTAGAGTACC AAGAGGCTAT TTTAGCCTGC AAAACCCCAA AGAAGACTGT TTCCTCCAGA 420 TTAGAGTGGA AGAAACTGGG TCGGAGTGTC TCCTTTGTCT ACTATCAACA GACTCTTCAA 480 GGTGATTTTA AAAATCGAGC TGAGATGATA GATTTCAATA TCCGGATCAA AAATGTGACA 540 AGAAGTGATG CGGGGAAATA TCGTTGTGAA GTTAGTGCCC CATCTGAGCA AGGCCAAAAC 600 CTGGAAGAGG ATACAGTCAC TCTGGAAGTA TTAGTGGCTC CAGCAGTTCC ATCATGTGAA 660 GTACCCTCTT CTGCTCTGAG TGGAACTGTG GTAGAGCTAC GATGTCAAGA CAAAGAAGGG 720 AATCCAGCTC CTGAATACAC ATGGTTTAAG GATGGCATCC GTTTGCTAGA AAATCCCAGA 780 CTTGGCTCCC AAAGCACCAA CAGCTCATAC ACAATGAATA CAAAAACTGG AACTCTGCAA 840 TTTAATACTG TTTCCAAACT GGACACTGGA GAATATTCCT GTGAAGCCCG CAATTCTGTT 900 GGATATCGCA GGTGTCCTGG GAAACGAATG CAAGTAGATG ATCTCAACAT AAGTGGCATC 960 ATAGCAGCCG TAGTAGTTGT GGCCTTAGTG ATTTCCGTTT GTGGCCTTGG TGTATGCTAT 1020 GCTCAGAGGA AAGGCTACTT TTCAAAAGAA ACCTCCTTCC AGAAGAGTAA TTCTTCATCT 1080 AAAGCCACGA CAATGAGTGA AAATGATTTC AAGCACACAA AATCCTTTAT AATTTAAAGA 1140 CTCCACTTTA GAGATACACC AAAGCCACCG TTGTTACACA AGTTATTAAA CTATTATAAA 1200 ACTCTGCTTT GTCCGACATT TGCAAAGAGG TACACGAGGA AATGGAATTG GTATTTCATT 1260 TTAATTTTCA TGACTACTAA CTCACCTGAA CTTGCTATTT TAAAMAAATA GTTCTGTCGA 1320 CACCTAAAAT ATAATCTGGC TTCTTGTGTC TGGACTAAGT TAAAAGAATT AAAATACTTT 1380 GTAATGTCAA AAAAAAA
Protein sequence 12
Gene name: vascular endothelial junction-associated molecule
Unigene number: Hs.54650
Protein Accession if: AAF81223
Signal sequence: 1-22
Igc2 domain: 41-116, 146-221
Transmembrane domains: 239-261
Cellular Localization: plasma membrane
1 11 21 31 41 51
I I I I I I
MARRSRHRLL LLLLRYLWA LGYHKAYGFS APKDQQWTA VEYQEAILAC KTPKKTVSSR 60 LEWKKLGRSV SFVYYQQTLQ GDFKNRAEMI DFNIRIKNVT RSDAGKYRCE VSAPSEQGQN 120 LEEDTVTLEV LVAPAVPSCE VPSSALSGTV VELRCQDKEG NPAPEYTWFK DGIRLLENPR 180 LGSQSTNSSY TMNTKTGTLQ FNTVSKLDTG EYSCEARNSV GYRRCPGKRM QVDDLNISGI 240 IAAWWALV ISVCGLGVCY AQRKGYFSKE TSFQKSNSSS KATTMSENDF KHTKSFII
DNA sequence 13
Gene name: solute carrier family 11 (proton-coupled divalent metal on
Unigene number: Hs.182611
Probeset Accession #: D50402
Nucleic Acid Accession #: NM_000578
Coding sequence: 1-1653
1 11 21 31 41 51
I I I I I I
ATGACAGGTG ACAAGGGTCC CCAAAGGCTA AGCGGGTCCA GCTATGGTTC CATCTCCAGC 60 CCGACCAGCC CGACCAGCCC AGGGCCACAG CAAGCACCTC CCAGAGAGAC CTACCTGAGT 120 GAGAAGATCC CCATCCCAGA CACAAAACCG GGCACCTTCA GGCTGCGGAA GCTATGGGCC 180 TTCACGGGGC CTGGCTTCCT CATGAGCATT GCTTTCCTGG ACCCAGGAAA CATCGAGTCA 240 GATCTTCAGC TNGGNCCNGT GGCGGGATTC AAACTTCTCT GGGTGCTGCT CTGGGCCACC 300 GTGTTGGGCT TGCTCTGCCA GCGACTGGCT GCACGTCTGG GCGTGGTGAC AGGCAAGGAC 360 TTGGGCGAGG TCTGCCATCT CTACTACCCT AAGGTGCCCC GCACCGTCCT CTGGCTGACC 420 ATCGAGCTAG CCATTGTGGG CTCCGACATG CAGGAAGTCA TCGGCACGGC CATTGCATTC 480 AATCTGCTCT CAGCTGGACG AATCCCACTC TGGGGTGGCG TCCTCATCAC CATCGTGGAC 540 ACCTTCTTCT TCCTCTTCCT CGATAACTAC GGGCTGCGGA AGCTGGAAGC TTTTTTTGGA 600 CTCCTTATAA CCATTATGGC CTTGACCTTT GGCTATGAGT ATGTGGTGGC GCGTCCTGAG 660 CAGGGAGCGC TTCTTCGGGG CCTGTTCCTG CCCTCGTGCC CGGGCTGCGG CCACCCCGAG 720 CTGCTGCAGG CGGTGGGCAT TGTTGGCGCC ATCATCATGC CCCACAACAT CTACCTGCAC 780 TCGGCCCTGG TCAAGTCTCG AGAGATAGAC CGGGCCCGCC GAGTCGACAT CAGAGAAGCC 840 AACATGTACT TCCTGATTGA GGCCACCATC GCCCTGTCCG TCTCCTTTAT CATCAACCTC 900 TTTGTCATGG CTGCATTTGG GCAGGCCTTC TACCAGAAAA CCAAGCAGGC TGCGTTCAAC 960 ATCTGTGCCA ACAGCAGCCT CCACGACTAC GCTAAGATCT TCCCCATGAA CAACGCCACC 1020 GTGGCCGTGG ACATTTACCA GGGGGGCGTG ATCCTGGGCT GCCTGTTCGG CCCCGCGGCC 1080 CTCTACATCT GGGCCATAGG TCTCCTGGCG GCTGGGCAGA GCTCCACCAT GACGGGCACC 1140 TACGCGGGAC AGTTCGTGAT GGAGGGCTTC CTGAGGCTGC GGTGGTCAAG CTTCGCCCGT 1200 GTCCTCCTCA CCCGCTCCTG CGCCATCCTG CCCACCGTGC TCGTGGCTGT CTTCCGGGAC 1260 CTGAGGGACT TGTCGGGCCT CAATGATCTG CTCAACGTGC TGCAGAGCCT GCTGCTCCCG 1320 GTTGCCGTGC TGCCCATCCT CACGTTCACC AGCATGCCCA CCCTCATGCA GGAGTTTGCC 1380 AATGGCCTGC TGAACAAGGT CGTCACCTCT TCCATCATGG TGCTAGTCTG CACCATCAAC 1440 CTCTACTTCG TGGTCAGCTA TCTGCCCAGC CTGCCCCACC CTGCCTACTT CGGCCTTGCA 1500 GCCTTGCTGG CCGCAGCCTA CCTGGGCCTC AGCACCTACC TGGTCTGGAC CTGTTGCCTT 1560 GCCCACGGAG CCACCTTTCT GGCCCACAGC TCCCACCACC ACTTCCTGTA TGGGCTCCTT 1620 GAAGAGGACC ACAAAGGGGA GACCTCTGGC TAG
Protem sequence 13
Gene name- solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Unigene number: Hs.182611
Protein Accession #: NP_000569
Signal sequence: none found
Pfam domain: Nramp [78-463]
Transmembrane domains: 58-80, 88-110, 159-181, 195-217, 284-306, 349-379, 394-416, 432-454, 468-490, 501-523
Cellular Localization: plasma membrane
1 11 21 31 41 51
I I I I I I
MTGDKGPQRL SGSSYGSISS PTSPTSPGPQ QAPPRETYLS EKIPIPDTKP GTFRLRKL A 60
FTGPGFLMSI AFLDPGNIES DLQLGPVAGF KLLWVLLWAT VLGLLCQRLA ARLGWTGKD 120
LGEVCHLYYP KVPRTVLWLT IELAIVGSDM QEVIGTAIAF NLLSAGRIPL GGVLITIVD 180
TFFFLFLDNY GLRKLEAFFG LLITIMALTF GYEYWARPE QGALLRGLFL PSCPGCGHPE 240
LLQAVGIVGA IIMPHNIYLH SALVKSREID RARRVDIREA NMYFLIEATI ALSVSFIINL 300
FVMAAFGQAF YQKTKQAAFN ICANSSLHDY AKIFPMNNAT VAVDIYQGGV ILGCLFGPAA 360
LYIWAIGLLA AGQSSTMTGT YAGQFVMEGF LRLRWSSFAR VLLTRSCAIL PTVLVAVFRD 420
LRDLSGLNDL LNVLQSLLLP VAVLPILTFT SMPTLMQEFA NGLLNKWTS SIMVLVCTIN 480
LYFWSYLPS LPHPAYFGLA ALLAAAYLGL STYLVWTCCL AHGATFLAHS SHHHFLYGLL 540 EEDHKGETSG
DNA sequence 14
Gene name: solute carrier family 7 (cationic amino acid transporter, y+ Unigene number: Hs.184601 Probeset Accession #- AF104032 Nucleic Acid Accession #: NM_003 Coding sequence: 53-1576 1 11 21 31 41 51
I I I 1 1 1 1
GCTCGCTGGG CCGCTGCTCC CGGGTGTCCC AGGCCCGGCC GGTGCGCAGA GCATGGCGGG 60 TGCGGGCCCG AAGCGGCGCG CGCTAGCGGC GCCGGCGGCC GAGGAGAAGG AAGAGGCGCG 120 GGAGAAGATG CTGGCCGCCA AGAGCGCGGA CGGCTCGGCG CCGGCAGGCG AGGGCGAGGG 180 CGTGACCCTG CAGCGGAACA TCACGCTGCT CAACGGCGTG GCCATCATCG TGGGGACCAT 240 TATCGGCTCG GGCATCTTCG TGACGCCCAC GGGCGTGCTC AAGGAGGCAG GCTCGCCGGG 300 GCTGGCGCTG GTGGTGTGGG CCGCGTGCGG CGTCTTCTCC ATCGTGGGCG CGCTCTGCTA 360 CGCGGAGCTC GGCACCACCA TCTCCAAATC GGGCGGCGAC TACGCCTACA TGCTGGAGGT 420 CTACGGCTCG CTGCCCGCCT TCCTCAAGCT CTGGATCGAG CTGCTCATCA TCCGGCCTTC 480 ATCGCAGTAC ATCGTGGCCC TGGTCTTCGC CACCTACCTG CTCAAGCCGC TCTTCCCCAC 540 CTGCCCGGTG CCCGAGGAGG CAGCCAAGCT CGTGGCCTGC CTGTGCGTGC TGCTGCTCAC 600 GGCCGTGAAC TGCTACAGCG TGAAGGCCGC CACCCGGGTC CAGGATGCCT TTGCCGCCGC 660 CAAGCTCCTG GCCCTGGCCC TGATCATCCT GCTGGGCTTC GTCCAGATCG GAAAGGGTGA 720 TGTGTCCAAT CTAGATCCCA AGTTCTCATT TGAAGGCACC AAACTGGATG TGGGGAACAT 780 TGTGCTGGCA TTATACAGCG GCCTCTTTGC CTATGGAGGA TGGAATTACT TGAATTTCGT 840 CACAGAGGAA ATGATCAACC CCTACAGAAA CCTGCCCCTG GCCATCATCA TCTCCCTGCC 900 CATCGTGACG CTGGTGTACG TGCTGACCAA CCTGGCCTAC TTCACCACCC TGTCCACCGA 960 GCAGATGCTG TCGTCCGAGG CCGTGGCCGT GGACTTCGGG AACTATCACC TGGGCGTCAT 1020 GTCCTGGATC ATCCCCGTCT TCGTGGGCCT GTCCTGCTTT GGCTCCGTCA ATGGGTCCCT 1080 GTTCACATCC TCCAGGCTCT TCTTCGTGGG GTCCCGGGAA GGCCACCTGC CCTCCATCCT 1140 CTCCATGATC CACCCACAGC TCCTCACCCC CGTGCCGTCC CTCGTGTTCA CGTGTGTGAT 1200 GACGCTGCTC TACGCCTTCT CCAAGGACAT CTTCTCCGTC ATCAACTTCT TCAGCTTCTT 1260 CAACTGGCTC TGCGTGGCCC TGGCCATCAT CGGCATGATC TGGCTGCGCC ACAGAAAGCC 1320 TGAGCTTGAG CGGCCCATCA AGGTGAACCT GGCCCTGCCT GTGTTCTTCA TCCTGGCCTG 1380 CCTCTTCCTG ATCGCCGTCT CCTTCTGGAA GACACCCGTG GAGTGTGGCA TCGGCTTCAC 1440 CATCATCCTC AGCGGGCTGC CCGTCTACTT CTTCGGGGTC TGGTGGAAAA ACAAGCCCAA 1500 GTGGCTCCTC CAGGGCATCT TCTCCACGAC CGTCCTGTGT CAGAAGCTCA TGCAGGTGGT 1560 CCCCCAGGAG ACATAGCCAG GAGGCCGAGT GGCTGCCGGA GGAGCATGC
Protem sequence 14
Gene name: solute carrier family 7 (cationic ammo acid transporter, y+
Unigene number: Hs.184601
Prote Accession #: NP_003477
Pfam domain: aa permeases [46-481]
Transmembrane domains: 52-74, 82-104 120-142, 145-167, 169-191, 200-222, 237-259, 275-297, 323-345, 371-393,
398-419, 430-452, 455-476
Cellular Localization: plasma membrane
1 11 21 31 41 51
I I I I I I
MAGAGPKRRA LAAPAAEEKE EAREKMLAAK SADGSAPAGE GEGVTLQRNI TLLNGVAIIV 60
GTIIGSGIFV TPTGVLKEAG SPGLALW A ACGVFSIVGA LCYAELGTTI SKSGGDYAYM 120
LEVYGSLPAF LKLWIELLII RPSSQYIVAL VFATYLLKPL FPTCPVPEEA AKLVACLCVL 180
LLTAVNCYSV KAATRVQDAF AAAKLLALAL IILLGFVQIG KGDVSNLDPK FSFEGTKLDV 240
GNIVLALYSG LFAYGG NYL NFVTEEMINP YRNLPLAIII SLPIVTLVYV LTNLAYFTTL 300
STEQ LSSEA VAVDFGNYHL GVMS IIPVF VGLSCFGSVN GSLFTSSRLF FVGSREGHLP 360
SILSMIHPQL LTPVPSLVFT CVMTLLYAFS KDIFSVINFF SFFNWLCVAL AIIGMI LRH 420
RKPELERPIK VNLALPVFFI LACLFLIAVS FWKTPVECGI GFTIILSGLP VYFFGV KN 480 KPKHLLQGIF STTVLCQKLM QWPQET
DNA sequence 15
Gene name: Glutamate receptor subunit
Unigene number: Hs.249141
Nucleic Acid Accession ft: S40369
Coding sequence- 1-2943
60
120
180
Figure imgf000151_0001
240 ACCATGTGTC AGATCTTACC CAAAGGGGTT GTGTCTGTCC TTGGGCCCTC CTCTAGCCCA 300 GCATCTGCCT CCACCGTGAG CCATATCTGT GGAGAGAAGG AGATCCCCCA CATCAAGGTG 360 GGTCCCGAGG AGACACCCCG CCTTCAGTAC CTTCGCTTCG CGTCTGTCAG CCTGTACCCC 420 AGTAACGAGG ACGTCAGCTT GGCGGTCTCC CGAATCCTCA AGTCCTTCAA CTACCCCTCG 480 GCCAGCCTCA TCTGCGCCAA GGCTGAGTGC CTGCTGCGAT TGGAGGAACT GGTGCGTGGC 540 TTCCTCATCT CCAAGGAGAC GCTGTCAGTG AGGATGTTGG ACGACAGCCG GGACCCCACA 600 CCACTGCTCA AGGAGATCCG TGATGACAAG GTGTCCACCA TCATCATCGA CGCCAACGCC 660 TCCATCTCCC ACCTCATCCT CCGTAAGGCC TCGGAACTGG GAATGACCTC AGCGTTTTAC 720 AAGTACATCC TCACCACCAT GGACTTCCCC ATCCTGCATC TGGACGGTAT TGTGGAGGAC 780 TCCTCCAACA TCCTGGGCTT CTCCATGTTC AACACGTCCC ACCCCTTCTA CCCTGAGTTT 840 GTCCGCAGCC TCAACATGTC CTGGAGGGAG AACTGTGAAG CCAGCACCTA CCTGGGCCCT 900 GCGCTGTCAG CCGCCCTGAT GTTTGACGCC GTGCACGTGG TGGTGAGCGC TGTCCGAGAG 960 CTGAACCGCA GCCAGGAGAT CGGTGTGAAG CCTCTGGCCT GTACATCGGC CAACATTTGG 1020 CCCCACGGGA CCAGCCTCAT GAACTACCTG CGCATGGTAG AGTATGATGG GCTGACCGGG 1080 CGGGTCGAGT TCAACAGCAA AGGGCAGAGA ACCAACTACA CCCTGCGCAT CCTAGAAAAG 1140 TCCCGGCAGG GCCACCGTGA GATTGGGGTG TGGTACTCTA ACCGCACCCT GGCCATGAAT 1200 GCCACCACCC TGGACATCAA CCTGTCGCAG ACACTGGCCA ACAAGACCCT GGTGGTCACA 1260 ACCATCCTGG AGAACCCATA CGTCATGCGC CGGCCCAACT TCCAGGGCCT GTCGGGGAAC 1320 GAACGCTTCG AGGGCTTCTG CGTGGACATG CTGCGGGAGC TGGCCGAGCT GCTGCCGTTC 1380 CCGTACCGCC TGCGGTTGGT GGAGGATGGG CTGTACGGGG CGCCCGAGCC CAACGGCTCC 1440 TGGACGGGCA TGGTTGGCGA GCTCATCAAC CGGAAGGCAG ACCTGGCTGT GGCCGCCTTC 1500 ACCATCACAG CTGAGCGGGA GAAGGTCATC GACTTTTCCA AGCCCTTTAT GACCCTGGGG 1560 ATCAGCATCC TCTACCGAGT GCACATGGGC CGCAAGCCTG GCTACTTCTC CTTCCTGGAC 1620 CCCTTCTCCC CTGCTGTGTG GCTCTTCATG CTTCTTGCCT ACCTGGCTGT CAGCTGCGTC 1680 CTGTTTCTGG CTGCCAGGCT GAGCCCCTAT GAGTGGTATA ACCCACACCC ATGCCTGCGG 1740 GCACGCCCCC ACATCCTGGA GAACCAGTAC ACGCTGGGCA ACAGCCTGTG GTTTCCCGTG 1800 GGGGGCTTCA TGCAGCAGGG CTCGGAGATC ATGCCCCGGG CGCTGTCCAC GCGCTGTGTC 1860 AGCGGAGTCT GGTGGGCCTT CACCTTGATC ATCATCTCCT CCTACACGGC CAACCTGGCC 1920 GCCTTCCTCA CCGTGCAGCG CATGGAGGTG CCTGTGGAGT CGGCCGATGA CCTGGCAGAT 1980 CAGACCAACA TCGAGTATGG CACCATCCAC GCCGGCTCCA CCATGACCTT CTTCCAGAAT 2040 TCACGGTACC AAACGTACCA GCGCATGTGG AACTACATGC AGTCGAAGCA GCCCAGCGTG 2100 TTCGTCAAGA GCACAGAAGA GGGCATTGCC GCCGTCCTCA ACTCCCGCTA CGCCTTCCTG 2160 CTCGAGTCCA CCATGAACGA ATACCACCGG CGCCTCAACT GCAACCTCAC CCAGATCGGG 2220 GGACTCCTCG ACACCAAGGG CTACGGCATT GGCATGCCGC TGGGCTCCCC GTTCCGGGAT 2280 GAGATCACAC TGGCCATCCT GCAGCTTCAG GAGAACAACC GGCTGGAGAT CCTGAAGCGC 2340 AAGTGGTGGG AGGGGGGCCG GTGCCCCAAG GAGGAGGACC ATCGAGCTAA AGGTTTGGGC 2400 ATGGAGAACA TTGGTGGCAT TTTTATCGTG CTCATCTGTG GCCTCATCAT TGCTGTCTTC 2460 GTGGCGGTCA TGGAATTCAT ATGGTCCACA CGGAGGTCAG CTGAGTCCGA GGAGGTGTCG 2520 GTGTGCCAGG AGATGCTGCA GGAGCTGCGC CACGCCGTTT CTTGCCGCAA GACGTCGCGT 2580 TCCCGCCGGC GCCGACGCCC GGGCGGCCCG AGCCGGGCCC TGCTGTCACT GCGCGCGGTC 2640 CGCGAGATGC GCCTCAGCAA CGGCAAGCTC TACTCGGCCG GCGCGGGCGG GGATGCGGGC 2700 AGCGCGCACG GGGGCCCGCA GGGCCTCCTG GACGACCCGG GGCCCCCCAG CGGAGCCCGA 2760 CCCGCCGCCC CCACCCCCTG CACCCACGTG CGCGTCTGCC AGGAGTGCCG GCGCATCCAG 2820 GCGCTGCGGG CCTCGGGGGC CGGCGCGCCT CCGCGTGGCC TGGGCGTCCC CGCCGAAGCC 2880 ACCAGCCCGC CCCGGCCGCG GCCTGGCCCC GCCGGCCCCC GGGAGCTGGC GGAGCACGAG 2940 TGA
Protein sequence 15
Gene name: Glutamate receptor subunit
Unigene number: Hs.249141
Protein Accession #: AAB22591
Signal sequence: 1-27
Pfam domain: ANF receptor [343-400] ;PBPe domain [416-7 85 , 799-838]
Transmembrane domains: 297-319, 544-566, 624-646, 803- 825
Cellular Localization: plasma membrane
1 11 21 31 41 51
MlPAELLLLLI VlAFASPSCQV LlSSLRMAAIL DlDQTVCGRGE RlLALALAREQ INGIIEVPAK 60 ARVEVDIFEL QRDSQYETTD TMCQILPKGV VSVLGPSSSP ASASTVSHIC GEKEIPHIKV 120 GPEETPRLQY LRFASVSLYP SNEDVSLAVS RILKSFNYPS ASLICAKAEC LLRLEELVRG 180 FLISKETLSV RMLDDSRDPT PLLKEIRDDK VSTIIIDANA SISHLILRKA SELGMTSAFY 240 KYILTTMDFP ILHLDGIVED SSNILGFSMF NTSHPFYPEF VRSLNMS RE NCEASTYLGP 300 ALSAALMFDA VH WSAVRE LNRSQEIGVK PLACTSANIW PHGTSLMNYL RMVEYDGLTG 360 RVEFNSKGQR TNYTLRILEK SRQGHREIGV WYSNRTLAMN ATTLDINLSQ TLANKTLWT 420 TILENPYV R RPNFQGLSGN ERFEGFCVDM LRELAELLPF PYRLRLVEDG LYGAPEPNGS 480 WTGMVGELIN RKADLAVAAF TITAEREKVI DFSKPFMTLG ISILYRVHMG RKPGYFSFLD 540 PFSPAVHLFM LLAYLAVSCV LFLAARLSPY EWYNPHPCLR ARPHILENQY TLGNSL FPV 600 GGFMQQGSEI MPRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMEV PVESADDLAD 660 QTNIEYGTIH AGSTMTFFQN SRYQTYQRMW NYMQSKQPSV FVKSTEEGIA AVLNSRYAFL 720 LESTMNEYHR RLNCNLTQIG GLLDTKGYGI GMPLGSPFRD EITLAILQLQ ENNRLEILKR 780 KW EGGRCPK EEDHRAKGLG MENIGGIFIV LICGLIIAVF VAVMEFIWST RRSAESEEVS 840 VCQEMLQELR HAVSCRKTSR SRRRRRPGGP SRALLSLRAV REMRLSNGKL YSAGAGGDAG 900 SAHGGPQRLL DDPGPPSGAR PAAPTPCTHV RVCQECRRIQ ALRASGAGAP PRGLGVPAEA 960 TSPPRPRPGP AGPRELAEHE
DNA sequence 16
Gene name : adenosine A3 receptor
Unigene number: Hs.258
Probeset Accession #: N _000677
Nucleic Acid Accession #: NM_000677
Coding sequence: 768-1724
1 11 21 31
AlTCTTTGCTG ClAAAGGCTGG GlTATCGGCTG TlGCTCAGCAA AGCGTCAACT CGTGCAAGAA 60 CTTAGCAGGA ATAGTTCTGG CTAAGGTTAG GAGGCTGCCA CCAAAGTCTC TTTTTTGTTC 120 CTCTGCTTCT CCCGTTTGCC TCCTTATCAT GAGATCTTTT TGCTAAGCTG GCAGAAAGAT 180 TGCATAGTCA GTGCTTCCAG CTCTGCTCCC ACCTGATCCT GCACTGTCCT CTGGTCCCTG 240 AATGAATGAA CTCTGATACC CAATCTTGTC TCGAGCCTTC TCTATGCCAC TCATGGCTCC 300 TCTTCTGCTC TTTCCATCTT TTTGCTGAGA GTTCTGAGCT CTGTACTTCC TCTTGGCCCA 360 TCTCACTTCC TGAAACACCC CTGAAGAGGG TTGCTTATCT TGATGGAACT CAAAAAGCCA 420 AAAAGCTGCA GGCAGAGGCG TTGAGGACAT CTGTTTGGGG AACTAAGAGC AGCAGCACTT 480 TCAGATTCAG TCCATATAGA GCTGTCCTAC AGCATTCTGG AAACTTGAGG ATGTGCGGTG 540 CATAAAGGGG CTGGAAGTGA CCCACCTGTG ATGAGCCCTT TCTAAGGAGA AGGGTTTCCA 600 AGAGATCACC CCACCAGAAA AGGGTAGGAA TGAGCAAGTT GGGAATTTTA GACTGTCACT 660 GCACATGGAC CTCTGGGAAG ACGTCTGGCG AGAGCTAGGC CCACTGGCCC TACAGACGGA 720 TCTTGCTGGC TCACCTGTCC CTGTGGAGGT TCCCCTGGGA AGGCAAGATG CCCAACAACA 780 GCACTGCTCT GTCATTGGCC AATGTTACCT ACATCACCAT GGAAATTTTC ATTGGACTCT 840 GCGCCATAGT GGGCAACGTG CTGGTCATCT GCGTGGTCAA GCTGAACCCC AGCCTGCAGA 900 CCACCACCTT CTATTTCATT GTCTCTCTAG CCCTGGCTGA CATTGCTGTT GGGGTGCTGG 960 TCATGCCTTT GGCCATTGTT GTCAGCCTGG GCATCACAAT CCACTTCTAC AGCTGCCTTT 1020 TTATGACTTG CCTACTGCTT ATCTTTACCC ACGCCTCCAT CATGTCCTTG CTGGCCATCG 1080 CTGTGGACCG ATACTTGCGG GTCAAGCTTA CCGTCAGATA CAAGAGGGTC ACCACTCACA 1140 GAAGAATATG GCTGGCCCTG GGCCTTTGCT GGCTGGTGTC ATTCCTGGTG GGATTGACCC 1200 CCATGTTTGG CTGGAACATG AAACTGACCT CAGAGTACCA CAGAAATGTC ACCTTCCTTT 1260 CATGCCAATT TGTTTCCGTC ATGAGAATGG ACTACATGGT ATACTTCAGC TTCCTCACCT 1320 GGATTTTCAT CCCCCTGGTT GTCATGTGCG CCATCTATCT TGACATCTTT TACATCATTC 1380 GGAACAAACT CAGTCTGAAC TTATCTAACT CCAAAGAGAC AGGTGCATTT TATGGACGGG 1440 AGTTCAAGAC GGCTAAGTCC TTGTTTCTGG TTCTTTTCTT GTTTGCTCTG TCATGGCTGC 1500 CTTTATCTAT CATCAACTGC ATCATCTACT TTAATGGTGA GGTACCACAG CTTGTGCTGT 1560 ACATGGGCAT CCTGCTGTCC CATGCCAACT CCATGATGAA CCCTATCGTC TATGCCTATA 1620 AAATAAAGAA GTTCAAGGAA ACCTACCTTT TGATCCTCAA AGCCTGTGTG GTCTGCCATC 1680 CCTCTGATTC TTTGGACACA AGCATTGAGA AGAATTCTGA GTAGTTATCC ATCAGAGATG 1740 ACTCTGTCTC ATTGACCTTC AGATTCCCCA TCAACAAACA CTTGAGGGCC TGTATGCCTG 1800 GGCCAAGGGA TTTTTACATC CTTGATTACT TCCACTGAGG TGGGAGCATC TCCAGTGCTC 1860 CCCAATTATA TCTCCCCCAC TCCACTACTC TCTTCCTCCA CTTCATTTTT CCTTTGTCCT 1920 TTCTCTCTAA TTCAGTGTTT TGGAGGCCTG ACTTGGGGAC AACGTATTAT TGATATTATT 1980 GTCTGTTTTC CTTCTTCCCA ATAGAAGAAT AAGTCATGGA GCCTGAAGGG TGCCTAGTTG 2040 ACTTACTGAC AAAAGGCTCT AGTTGGGCTG AACATGTGTG TGGTGGTGAC TCATTTCCAT 2100 GCCATTGTGG AATTGAGCAG AGAACCTGCT CTCGGAGGAT GCCTAGAAGA TGTTGGGAAC 2160 AGAAGAAATA AACTGAGTTT AAGGGGGACT TAAACTGCTG AATTCACCTG TGGATGTTTT 2220 TGAGTAAATA AAAGCTAATA G
Protein sequence 16
Gene name adenosine A3 receptor
Unigene number Hs 258
Prote Accession # NP_000668
Signal sequence none found
Pfam domain 7tm_l [29-282]
Transmembrane domains 12-34, 50-72, 86-108, 120-150, 179-201, 229-251
Cellular Localization plasma membrane
1 11 21 31 41 51
I I I I I I
MPNNSTALSL ANVTYITMEI FIGLCAIVGN VLVICWKLN PSLQTTTFYF IVSI-ALADIA 60
VGVLVMPI-AI WSLGITIHF YSCLFMTCLL LIFTHASIMS LLAIAVDRYL RVKLTVRYKR 120
VTTHRRIWLA LGLCWLVSFL VGLTPMFG N MKLTSEYHRN VTFLSCQFVS VMRMDYMVYF 180
SFLT IFIPL WMCAIYLDI FYIIRNKLSL NLSNSKETGA FYGREFKTAK SLFLVLFLFA 240
LSWLPLSIIN CIIYFNGEVP QLVLYMGILL SHANSMMNPI VYAYKIKKFK ETYLLILKAC 300 WCHPSDSLD TSIEKNSE
DNA sequence 17
Gene name glypican 1
Unigene number Hs 2699
Probeset Accession # X54232
Nucleic Acid Accession # NM_002
Coding sequence 222 1898
1 11 21
I I I
GGCTGCCCGA GCGAGCGTTC GGACCTCGCA CCCCGCGCGC CCCGCGCCGC CGCCGCCGCC 60 GGCTTTTGTT GTCTCCGCCT CCTCGGCCGC CGCCGCCTCT GGACCGCGAG CCGCGCGCGC 120 CGGGACCTTG GCTCTGCCCT TCGCGGGCGG GAACTGCGCA GGACCCGGCC AGGATCCGAG 180 AGAGGCGCGG GCGGGTGGCC GGGGGCGCCG CCGGCCCCGC CATGGAGCTC CGGGCCCGAG 240 GCTGGTGGCT GCTATGTGCG GCCGCAGCGC TGGTCGCCTG CGCCCGCGGG GACCCGGCCA 300 GCAAGAGCCG GAGCTGCGGC GAGGTCCGCC AGATCTACGG AGCCAAGGGC TTCAGCCTGA 360 GCGACGTGCC CCAGGCGGAG ATCTCGGGTG AGCACCTGCG GATCTGTCCC CAGGGCTACA 420 CCTGCTGCAC CAGCGAGATG GAGGAGAACC TGGCCAACCG CAGCCATGCC GAGCTGGAGA 480 CCGCGCTCCG GGACAGCAGC CGCGTCCTGC AGGCGATGCT TGCCACCCAG CTGCGCAGCT 540 TCGATGACCA CTTCCAGCAC CTGCTGAACG ACTCGGAGCG GACGCTGCAG GCCACCTTCC 600 CCGGCGCCTT CGGAGAGCTG TACACGCAGA ACGCGAGGGC CTTCCGGGAC CTGTACTCAG 660 AGCTGCGCCT GTACTACCGC GGTGCCAACC TGCACCTGGA GGAGACGCTG GCCGAGTTCT 720 GGGCCCGCCT GCTCGAGCGC CTCTTCAAGC AGCTGCACCC CCAGCTGCTG CTGCCTGATG 780 ACTACCTGGA CTGCCTGGGC AAGCAGGCCG AGGCGCTGCG GCCCTTCGGG GAGGCCCCGA 840 GAGAGCTGCG CCTGCGGGCC ACCCGTGCCT TCGTGGCTGC TCGCTCCTTT GTGCAGGGCC 900 TGGGCGTGGC CAGCGACGTG GTCCGGAAAG TGGCTCAGGT CCCCCTGGGC CCGGAGTGCT 960 CGAGAGCTGT CATGAAGCTG GTCTACTGTG CTCACTGCCT GGGAGTCCCC GGCGCCAGGC 1020 CCTGCCCTGA CTATTGCCGA AATGTGCTCA AGGGCTGCCT TGCCAACCAG GCCGACCTGG 1080 ACGCCGAGTG GAGGAACCTC CTGGACTCCA TGGTGCTCAT CACCGACAAG TTCTGGGGTA 1140 CATCGGGTGT GGAGAGTGTC ATCGGCAGCG TGCACACGTG GCTGGCGGAG GCCATCAACG 1200 CCCTCCAGGA CAACAGGGAC ACGCTCACGG CCAAGGTCAT CCAGGGCTGC GGGAACCCCA 1260 AGGTCAACCC CCAGGGCCCT GGGCCTGAGG AGAAGCGGCG CCGGGGCAAG CTGGCCCCGC 1320 GGGAGAGGCC ACCTTCAGGC ACGCTGGAGA AGCTGGTCTC TGAAGCCAAG GCCCAGCTCC 1380 GCGACGTCCA GGACTTCTGG ATCAGCCTCC CAGGGACACT GTGCAGTGAG AAGATGGCCC 1440 TGAGCACTGC CAGTGATGAC CGCTGCTGGA ACGGGATGGC CAGAGGCCGG TACCTCCCCG 1500 AGGTCATGGG TGACGGCCTG GCCAACCAGA TCAACAACCC CGAGGTGGAG GTGGACATCA 1560 CCAAGCCGGA CATGACCATC CGGCAGCAGA TCATGCAGCT GAAGATCATG ACCAACCGGC 1620 TGCGCAGCGC CTACAACGGC AACGACGTGG ACTTCCAGGA CGCCAGTGAC GACGGCAGCG 1680 GCTCGGGCAG CGGTGATGGC TGTCTGGATG ACCTCTGCGG CCGGAAGGTC AGCAGGAAGA 1740 GCTCCAGCTC CCGGACGCCC TTGACCCATG CCCTCCCAGG CCTGTCAGAG CAGGAAGGAC 1800 AGAAGACCTC GGCTGCCAGC TGCCCCCAGC CCCCGACCTT CCTCCTGCCC CTCCTCCTCT 1860 TCCTGGCCCT TACAGTAGCC AGGCCCCGGT GGCGGTAACT GCCCCAAGGC CCCAGGGACA 1920 GAGGCCAAGG ACTGACTTTG CCAAAAATAC AACACAGACG ATATTTAATT CACCTCAGCC 1980 TGGAGAGGCC TGGGGTGGGA CAGGGAGGGC CGGCGGCTCT GAGCAGGGGC AGGCGCAGAG 2040 GTCCCAGCCC CAGGCCTGGC CTCGCCTGCC TTTCTGCCTT TTAATTTTGT ATGAGGTCCT 2100 CAGGTCAGCT GGGAGCCAGT GTGCCCAAAA GCCATGTATT TCAGGGACCT CAGGGGCACC 2160 TCCGGCTGCC TAGCCCTCCC CCCAGCTCCC TGCACCGCCG CAGAAGCAGC CCCTCGAGGC 2220 CTACAGAGGA GGCCTCAAAG CAACCCGCTG GAGCCCACAG CGAGCCTGTG CCTTCCTCCC 2280 CGCCTCCTCC CACTGGGACT CCCAGCAGAG CCCACCAGCC AGCCCTGGCC CACCCCCCAG 2340 CCTCCAGAGA AGCCCCGCAC GGGCTGTCTG GGTGTCCGCC ATCCAGGGTC TGGCAGAGCC 2400 TCTGAGATGA TGCATGATGC CCTCCCCTCA GCGCAGGCTG CAGAGCCCGG CCCCACCTCC 2460
CTGCGCCCTT GAGGGGCCCC AGCGTCTGCA GGGTGACGCC TGAGACAGCA CCACTGCTGA 2520
GGAGTCTGAG GACTGTCCTC CCACAGACCC TGCAGTGAGG GGCCCTCCAT GCGCAGATGA 2580
GGGGCCACTG ACCCACCTGC GCTTCTGCTG GAGGAGGGGA AGCTGGGCCC AAAGGCCCAG 2640
GGAGGCAGCG TGGGCTCTGC CAATGTGGGC TGCCCCTCGC ACACAGGGCT CACAGGGCAG 2700
GCCTTGCTGG GGTCCAGGGC TGTTGGAGGA CCCCGAGGGC TGAGGAGCAG CCAGGACCCG 2760
CCTGCTCCCA TCCTCACCCA GATCAGGAAC CAGGGCCTCC CTGTTCACGG TGACACAGGT 2820
CAGGGCTCAG AGTGACCCTC GGCTGTCACC TGCTCACAGG GATGGTGGTG GCTGGTGAGA 2880
CCCCGCACTG CACACGGGAA TGCCTAGGTC CCTTCCCGAC CCAGCCAGCT GCACTGCAGG 2940
GCACGGGGAC CTGGATAGTT AAGGGCTTTT CCAAACATGC ATCCATTTAC TGACACTTCC 3000
TGTCCTTGTT CATGGAGAGC TGTTCGCTCC TCCCAGATGG CTTCGGAGGC CCGCAGGGCC 3060
CACCTTGGAC CCTGGTGACC TCCTGTCACT CACTGAGGCC ATCAGGGCCC TGCCCCAGGC 3120
CTGGACGGGC CCTCCTTCCC TCCTGTGCCC CAGCTGCCAG GTGGCCCTGG GGAGGGGTGG 3180
TGTGGTGTTG GGAAGGGGTC CTGCAGGGGG AGGAGGACTT GGAGGGTCTG GGGGCAGCTG 3240
TCCTGAACCG ACTGACCCTG AGGAGGCCGC TTAGTGCTGC TTTGCTTTTC ATCACCGTCC 3300
CGCACAGTGG ACGGAGGTCC CCGGTTGCTG GTCAGGTCCC CATGGCTTGT TCTCTGGAAC 3360
CTGACTTTAG ATGTTTTGGG ATCAGGAGCC CCCAACACAG GCAAGTCCAC CCCATAATAA 3420
CCCTGCCAGT GCCAGGGTGG GCTGGGGACT CTGGCACAGT GATGCCGGGC GCCAGGACAG 3480
CAGCACTCCC GCTGCACACA GACGGCCTAG GGGTGGCGCT CAGACCCCAC CCTACGCTCA 3540
TCTCTGGAAG GGGCAGCCCT GAGTGGTCAC TGGTCAGGGC AGTGGCCAAG CCTGCTGTGT 3600
CCTTCCTCCA CAAGGTCCCC CCACCGCTCA GTGTCAGCGG GTGACGTGTG TTCTTTTGAG 3660 TCCTTGTATG AATAAAAGGC TGGAAACCTA AA
Protein sequence 17
Gene name: glypican 1
Unigene number: Hs.2699
Protein Accession #: NP_002072
Signal sequence: none found
Pfam domain: Glypican protein [2-490]
Transmembrane domains : none found
Cellular Localization: plasma membrane
1 11 21 31 41 51
1 I I I I I
MELRARG WL LCAAAALVAC ARGDPASKSR SCGEVRQIYG AKGFSLSDVP QAEISGEHLR 60
ICPQGYTCCT SEMEENLANR SHAELETALR DSSRVLQAML ATQLRSFDDH FQHLLNDSER 120
TLQATFPGAF GELYTQNARA FRDLYSELRL YYRGANLHLE ETLAEFWARL LERLFKQLHP 180
QLLLPDDYLD CLGKQAEALR PFGEAPRELR LRATRAFVAA RSFVQGLGVA SDWRKVAQV 240
PLGPECSRAV MKLVYCAHCL GVPGARPCPD YCRNVLKGCL ANQADLDAE RNLLDSMVLI 300
TDKFWGTSGV ESVIGSVHT LAEAINALQD NRDTLTAKVI QGCGNPKVNP QGPGPEEKRR 360
RGKLAPRERP PSGTLEKLVS EAKAQLRDVQ DFWISLPGTL CSEKMALSTA SDDRC NGMA 420
RGRYLPEVMG DGLANQINNP EVEVDITKPD MTIRQQIMQL KIMTNRLRSA YNGNDVDFQD 480 ASDDGSGSGS
DNA sequence 18 Gene name: NY-REN-24 antigen Unigene number: Hs.128425 Nucleic Acid Accession #: AF155102 Coding sequence: 27-908 1 11 21 31
GCGAGGGCGA GGGCGAGGCG GTGCTCATGG AGGAGGACCT GATCCAGCAG AGCCTGGACG 60
ACTACGACGC CGGCAGGTAC AGCCCGCGGC TGCTCACGGC GCACGAGCTG CCACTGGACG 120
CGCACGTGCT GGAACCGGAT GAGGACCTGC AGCGCCTGCA GCTCTCGCGC CAGCAGCTCC 180
AGGTCACGGG AGACGCCAGC GAGAGCGCCG AGGACATCTT CTTCCGGCGG GCCAAGGAGG 240
GCATGGGCCA GGACGAGGCG CAGTTCAGCG TGGAGATGCC ACTCACCGGC AAGGCCTACC 300
TGTGGGCCGA CAAGTACCGG CCACGCAAGC CGCGCTTCTT CAACCGCGTG CACACGGGCT 360
TCGAGTGGAA CAAGTACAAC CAGACGCACT ACGACTTTGA CAACCCACCG CCCAAGATCG 420
TGCAGGGATA CAAGTTCAAC ATCTTCTACC CCGACCTCAT CGACAAGCGC TCCACGCCCG 480
AGTACTTCCT GGAGGCCTGC GCCGACAACA AGGATTTCGC CATCCTGCGC TTCACGCGGG 540
GCCGCCTACG AGGACATCGC TTTCAAGATC GTCAACCGCG AGTGGGAATA CTCGCACCGC 600
CACGGCTTCC GCTGCCAGTT TGCCAACGGC ATCTTCCAGC TGTGCTTTCA CTTCAAGCGC 660
TACCGCTATC GGCGGTGACG GCCCTGGGGA ACGGCAGGCC AGGAGGGCCG AGGGCCACAC 720
GGGTGCCACA GCCCAGGTCG GAGTGGCCCA GCCGGCAGGC TTGTTCTTCA GCATCCGACG 780
GGAACATCTC CAACAGAAGC AAAACGGAAA GTGCCTCCCG GACCCCCAGA GGGCCACCCA 840
ACCTCACCAG TCACCAGCCC CAGACCACCC ACAGCCCCTC CCAGACACCC CGCCTCATCT 900
GGAAATAGTT CCGTTTGTTT CTCTAAAAAG ACTTGTAGGT GGGAAAAAAA ATCTTTTGTT 960
CTCATGGAAT TGGCCTATTG GCAAGATCGC ATGTTTTTTT AATAAACGTT GTATTTTAGA 1020 ATAAAA
Protein sequence 18
Gene name: NY-REN-24 antigen
Unigene number- Hs.128425
Protein Accession #: AAD42868
Signal sequence : none found
Transmembrane domains . none found
Cellular Localization: plasma membrane
1 11 21 31 41 51
I 1 I I I I
GEGEAVLME EDLIQQSLDD YDAGRYSPRL LTAHELPLDA HVLEPDEDLQ RLQLSRQQLQ 60
TGDASESAE DIFFRRAKEG MGQDEAQFSV EMPLTGKAYL WADKYRPRKP RFFNRVHTGF 120 NKYNQTHY DFDNPPPKIV QGYKFNIFYP DLIDKRSTPE YFLEACADNK DFAILRFTRG 180
LRGHRFQDR QPRVGILAPP RLPLPVCQRH LPAVLSLQAL PLSAVTALGN GRPGGPRATR 240
PQPRSE PS RQACSSASDG NISNRSKTES ASRTPRGPPN LTSHQPQTTH SPSQTPRLI 300 DNA sequence 19
Gene name: tumor necrosis factor receptor superfamily, member 1A
Unigene number Hs .159
Probeset Accession # BE29S7S2
Nucleic Acid Accession #- NM_001065
Coding sequence- 256-1623
1 11 21 31 41 51
CGGCCCAGTG ATCTTGAACC CCAAAGGCCA GAACTGGAGC CTCAGTCCAG AGAATTCTGA 60 GAAAATTAAA GCAGAGAGGA GGGGAGAGAT CACTGGGACC AGGCCGTGAT CTCTATGCCC 120 GAGTCTCAAC CCTCAACTGT CACCCCAAGG CACTTGGGAC GTCCTGGACA GACCGAGTCC 180 CGGGAAGCCC CAGCACTGCC GCTGCCACAC TGCCCTGAGC CCAAATGGGG GAGTGAGAGG 240 CCATAGCTGT CTGGCATGGG CCTCTCCACC GTGCCTGACC TGCTGCTGCC GCTGGTGCTC 300 CTGGAGCTGT TGGTGGGAAT ATACCCCTCA GGGGTTATTG GACTGGTCCC TCACCTAGGG 360 GACAGGGAGA AGAGAGATAG TGTGTGTCCC CAAGGAAAAT ATATCCACCC TCAAAATAAT 420 TCGATTTGCT GTACCAAGTG CCACAAAGGA ACCTACTTGT ACAATGACTG TCCAGGCCCG 480 GGGCAGGATA CGGACTGCAG GGAGTGTGAG AGCGGCTCCT TCACCGCTTC AGAAAACCAC 540 CTCAGACACT GCCTCAGCTG CTCCAAATGC CGAAAGGAAA TGGGTCAGGT GGAGATCTCT 600 TCTTGCACAG TGGACCGGGA CACCGTGTGT GGCTGCAGGA AGAACCAGTA CCGGCATTAT 660 TGGAGTGAAA ACCTTTTCCA GTGCTTCAAT TGCAGCCTCT GCCTCAATGG GACCGTGCAC 720 CTCTCCTGCC AGGAGAAACA GAACACCGTG TGCACCTGCC ATGCAGGTTT CTTTCTAAGA 780 GAAAACGAGT GTGTCTCCTG TAGTAACTGT AAGAAAAGCC TGGAGTGCAC GAAGTTGTGC 840 CTACCCCAGA TTGAGAATGT TAAGGGCACT GAGGACTCAG GCACCACAGT GCTGTTGCCC 900 CTGGTCATTT TCTTTGGTCT TTGCCTTTTA TCCCTCCTCT TCATTGGTTT AATGTATCGC 960 TACCAACGGT GGAAGTCCAA GCTCTACTCC ATTGTTTGTG GGAAATCGAC ACCTGAAAAA 1020 GAGGGGGAGC TTGAAGGAAC TACTACTAAG CCCCTGGCCC CAAACCCAAG CTTCAGTCCC 1080 ACTCCAGGCT TCACCCCCAC CCTGGGCTTC AGTCCCGTGC CCAGTTCCAC CTTCACCTCC 1140 AGCTCCACCT ATACCCCCGG TGACTGTCCC AACTTTGCGG CTCCCCGCAG AGAGGTGGCA 1200 CCACCCTATC AGGGGGCΓGA CCCCATCCTT GCGACAGCCC TCGCCTCCGA CCCCATCCCC 1260 AACCCCCTTC AGAAGTGGGA GGACAGCGCC CACAAGCCAC AGAGCCTAGA CACTGATGAC 1320 CCCGCGACGC TGTACGCCGT GGTGGAGAAC GTGCCCCCGT TGCGCTGGAA GGAATTCGTG 1380 CGGCGCCTAG GGCTGAGCGA CCACGAGATC GATCGGCTGG AGCTGCAGAA CGGGCGCTGC 1440 CTGCGCGAGG CGCAATACAG CATGCTGGCG ACCTGGAGGC GGCGCACGCC GCGGCGCGAG 1500 GCCACGCTGG AGCTGGTGGG ACGCGTGCTC CGCGACATGG ACCTGCTGGG CTGCCTGGAG 1560 GACATCGAGG AGGCGCTTTG CGGCCCCGCC GCCCTCCCGC CCGCGCCCAG TCTTCTCAGA 1620 TGAGGCTGCG CCCCTGCGGG CAGCTCTAAG GACCGTCCTG CGAGATCGCC TTCCAACCCC 1680 ACTTTTTTCT GGAAAGGAGG GGTCCTGCAG GGGCAAGCAG GAGCTAGCAG CCGCCTACTT 1740 GGTGCTAACC CCTCGATGTA CATAGCTTTT CTCAGCTGCC TGCGCGCCGC CGACAGTCAG 1800 CGCTGTGCGC GCGGAGAGAG GTGCGCCGTG GGCTCAAGAG CCTGAGTGGG TGGTTTGCGA 1860 GGATGAGGGA CGCTATGCCT CATGCCCGTT TTGGGTGTCC TCACCAGCAA GGCTGCTCGG 1920 GGGCCCCTGG TTCGTCCCTG AGCCTTTTTC ACAGTGCATA AGCAGTTTTT TTTGTTTTTG 1980 TTTTGTTTTG TTTTGTTTTT AAATCAATCA TGTTACACTA ATAGAAACTT GGCACTCCTG 2040 TGCCCTCTGC CTGGACAAGC ACATAGCAAG CTGAACTGTC CTAAGGCAGG GGCGAGCACG 2100 GAACAATGGG GCCTTCAGCT GGAGCTGTGG ACTTTTGTAC ATACACTAAA ATTCTGAAGT 2160 T
Protein sequence 19
Gene name tumor necrosis factor receptor superfamily, member 1A
Unigene number. Hs.159
Protein Accession #• NP_001056
Signal sequence: 1-29
TNFR domain: 44-81, 84-125, 127-166, 168-195
Transmembrane domains : 211-234
Cellular Localization-, plasma membrane
1 11 21 31 41 51 l l l l l
MGLSTVPD.-.L LPLVLLEI.LV GIYPSGVIGL VPHLGDREKR DSVCPQGKYI HPQNNSICCT 60 KCHKGTYLYN DCPGPGQDTD CRECESGSFT ASENHLRHCL SCSKCRKEMG QVEISSCTVD 120 RDTVCGCRKN QYRHYWSENL FQCFNCSLCL NGTVHLSCQE KQNTVCTCHA GFFLRENECV 180 SCSNCKKSLE CTKLCLPQIE NVKGTEDSGT TVLLPLVIFF GLCLLSLLFI GLMYRYQRWK 240 SKLYSIVCGK STPEKEGELE GTTTKPLAPN PSFSPTPGFT PTLGFSPVPS STFTSSSTYT 300 PGDCPNFAAP RREVAPPYQG ADPILATALA SDPIPNPLQK EDSAHKPQS LDTDDPATLY 360 AWENVPPLR WKEFVRRI-GL SDHEIDRLEL QNGRCLREAQ YSMLAT RRR TPRREATLEL 420 LGRVLRDMDL LGCLEDIEEA LCGPAALPPA PSLLR
DNA sequence 20
Gene name: prommin (mouse) -like 1
Unigene number. Hs.112360
Probeset Accession #: R40057
Nucleic Acid Accession #.- WM_006017
Coding sequence- 38-2635
60
120
Figure imgf000155_0001
180 AGCTGGACCC ATTGGCATTC TCTTTGAACT AGTGCATATC TTTCTCTATG TGGTACAGCC 240 GCGTGATTTC CCAGAAGATA CTTTGAGAAA ATTCTTACAG AAGGCATATG AATCCAAAAT 300 TGATTATGAC AAGCCAGAAA CTGTAATCTT AGGTCTAAAG ATTGTCTACT ATGAAGCAGG 360 GATTATTCTA TGCTGTGTCC TGGGGCTGCT GTTTATTATT CTGATGCCTC TGGTGGGGTA 420 TTCT TTGT ATGTGTCGΓT GCTGΓAACAA ATGTGGTGGA GAAATGCACC AGCGACAGAA 480
GGAAAATGGG CCCTTCCTGA GGAAATGCTT TGCAATCTCC CTGTTGGTGA TTTGTATAAT 540 AATAAGCATT GGCATCTTCT ATGGTTTTGT GGCAAATCAC CAGGTAAGAA CCCGGATCAA 600 AAGGAGTCGG AAACTGGCAG ATAGCAATTT CAAGGACTTG CGAACTCTCT TGAATGAAAC 660 TCCAGAGCAA ATCAAATATA TATTGGCCCA GTACAACACT ACCAAGGACA AGGCGTTCAC 720 AGATCTGAAC AGTATCAATT CAGTGCTAGG AGGCGGAATT CTTGACCGAC TGAGACCCAA 780 CATCATCCCT GTTCTTGATG AGATTAAGTC CATGGCAACA GCGATCAAGG AGACCAAAGA 840 GGCGTTGGAβ AACATGAACA GCACCTTGAA GAGCTTGCAC CAACAAAGTA CACAGCTTAG 900 CAGCAGTCTG ACCAGCGTGA AAACTAGCCT GCGGTCATCT CTCAATGACC CTCTGTGCTT 960 GGTGCATCCA TCAAGTGAAA CCTGCAACAG CATCAGATTG TCTCTAAGCC AGCTGAATAG 1020 CAACCCTGAA CTGAGGCAGC TTCCACCCGT GGATGCAGAA CTTGACAACG TTAATAACGT 1080 TCTTAGGACA GATTTGGATG GCCTGGTCCA ACAGGGCTAT CAATCCCTTA ATGATATACC 1140 TGACAGAGTA CAACGCCAAA CCACGACTGT CGTAGCAGGT ATCAAAAGGG TCTTGAATTC 1200 CATTGGTTCA GATATCGACA ATGTAACTCA GCGTCTTCCT ATTCAGGATA TACTCTCAGC 1260 ATTCTCTGTT TATGTTAATA ACACTGAAAG TTACATCCAC AGAAATTTAC CTACATTGGA 1320 AGAGTATGAT TCATACTGGT GGCTGGGTGG CCTGGTCATC TGCTCTCTGC TGACCCTCAT 1380 CGTGATTTTT TACTACCTGG GCTTACTGTG TGGCGTGTGC GGCTATGACA GGCATGCCAC 1440 CCCGACCACC CGAGGCTGTG TCTCCAACAC CGGAGGCGTC TTCCTCATGG TTGGAGTTGG 1500 ATTAAGTTTC CTCTTTTGCT GGATATTGAT GATCATTGTG GTTCTTACCT TTGTCTTTGG 1560 TGCAAATGTG GAAAAACTGA TCTGTGAACC TTACACGAGC AAGGAATTAT TCCGGGTTTT 1620 GGATACACCC TACTTACTAA ATGAAGACTG GGAATACTAT CTCTCTGGGA AGCTATTTAA 1680 TAAATCAAAA ATGAAGCTCA CTTTTGAACA AGTTTACAGT GACTGCAAAA AAAATAGAGG 1740 CACTTACGGC ACTCTTCACC TGCAGAACAG CTTCAATATC AGTGAACATC TCAACATTAA 1800 TGAGCATACT GGAAGCATAA GCAGTGAATT GGAAAGTCTG AAGGTAAATC TTAATATCTT 1860 TCTGTTGGGT GCAGCAGGAA GAAAAAACCT TCAGGATTTT GCTGCTTGTG GAATAGACAG 1920 AATGAATTAT GACAGCTACT TGGCTCAGAC TGGTAAATCC CCCGCAGGAG TGAATCTTTT 1980 ATCATTTGCA TATGATCTAG AAGCAAAAGC AAACAGTTTG CCCCCAGGAA ATTTGAGGAA 2040 CTCCCTGAAA AGAGATGCAC AAACTATTAA AACAATTCAC CAGCAACGAG TCCTTCCTAT 2100 AGAACAATCA CTGAGCACTC TATACCAAAG CGTCAAGATA CTTCAACGCA CAGGGAATGG 2160 ATTGTTGGAG AGAGTAACTA GGATTCTAGC TTCTCTGGAT TTTGCTCAGA ACTTCATCAC 2220 AAACAATACT TCCTCTGTTA TTATTGAGGA AACTAAGAAG TATGGGAGAA CAATAATAGG 2280 ATATTTTGAA CATTATCTGC AGTGGATCGA GTTCTCTATC AGTGAGAAAG TGGCATCGTG 2340 CAAACCTGTG GCCACCGCTC TAGATACTGC TGTTGATGTC TTTCTGTGTA GCTACATTAT 2400 CGACCCCTTG AATTTGTTTT GGTTTGGCAT AGGAAAAGCT ACTGTATTTT TACTTCCGGC 2460 TCTAATTTTT GCGGTAAAAC TGGCTAAGTA CTATCGTCGA ATGGATTCGG AGGACGTGTA 2520 CGATGATGTT GAAACTATAC CCATGAAAAA TATGGAAAAT GGTAATAATG GTTATCATAA 2580 AGATCATGTA TATGGTATTC ACAATCCTGT TATGACAAGC CCATCACAAC ATTGATAGCT 2640 GATGTTGAAA CTGCTTGAGC ATCAGGATAC TCAAAGTGGA AAGGATCACA GATTTTTGGT 2700 AGTTTCTGGG TCTACAAGGA CTTTCCAAAT CCAGGAGCAA CGCCAGTGGC AACGTAGTGA 2760 CTCAGGCGGG CACCAAGGCA ACGGCACCAT TGGTCTCTGG GTAGTGCTTT AAGAATGAAC 2820 ACAATCACGT TATAGTCCAT GGTCCATCAC TATTCAAGGA TGACTCCCTC CCTTCCTGTC 2880 TATTTTTGTT TTTTACTTTT TTACACTGAG TTTCTATTTA GACACTACAA CATATGGGGT 2940 GTTTGTTCCC ATTGGATGCA TTTCTATCAA AACTCTATCA AATGTGATGG CTAGATTCTA 3000 ACATATTGCC ATGTGTGGAG TGTGCTGAAC ACACACCAGT TTACAGGAAA GATGCATTTT 3060 GTGTACAGTA AACGGTGTAT ATACCTTTTG TTACCACAGA GTTTTTT AA CAAATGAGTA 3120 TTATAGGACT TTCTTCTAAA TGAGCTAAAT AAGTCACCAT TGACTTCTTG GTGCTGTTGA 3180 AAATAATCCA TTTTCACTAA AAGTGTGTGA AACCTACAGC ATATTCTTCA CGCAGAGATT 3240 TTCATCTATT ATACTTTATC AAAGATTGGC CATGTTCCAC TTGGAAATGG CATGCAAAAG 3300 CCATCATAGA GAAACCTGCG TAACTCCATC TGACAAATTC AAAAGAGAGA GAGAGATCTT 3360 GAGAGAGAAA TGCTGTTCGT TCAAAAGTGG AGTTGTTTTA ACAGATGCCA ATTACGGTGT 3420 ACAGTTTAAC AGAGTTTTCT GTTGCATTAG GATAAACATT AATTGGAGTG CAGCTAACAT 3480 GAGTATCATC AGACTAGTAT CAAGTGTTCT AAAATGAAAT ATGAGAAGAT CCTGTCACAA 3540 TTCTTAGATC TGGTGTCCAG CATGGATGAA ACCTTTGAGT TTGGTCCCTA AATTTGCATG 3600 AAAGCACAAG GTAAATATTC ATTTGCTTCA GGAGTTTCAT GTTGGATCTG TCATTATCAA 3660 AAGTGATCAG CAATGAAGAA CTGGTCGGAC AAAATTTAAC GTTGATGTAA TGGAATTCCA 3720 GATGTAGGCA TTCCCCCCAG GTCTTTTCAT GTGCAGATTG CAGTTCTGAT TCATTTGAAT 3780 AAAAAGGAAC TTGGC
Protem sequence 20
Gene name: prommin (mouse) -like 1
Unigene number Hs.112360
Protein Accession #: NP_006008
Signal sequence: 1-21
Transmembrane domains: 105-127, 157-179, 43 8-460, 482-504, 784-806
Cellular Localization: plasma membrane
1 11 21 31 51 MlALVLGSLLL LlGLCGNSFSG GlQPSSTDAPK AlNYELPATN YETQDSHKAG PIGILFELVH 60 IFLYWQPRD FPEDTLRKFL QKAYESKIDY DKPETVILGL KIVYYEAGII LCCVLGLLFI 120 ILMPLVGYFF CMCRCCNKCG GEMHQRQKEN GPFLRKCFAI SLLVICIIIS IGIFYGFVAN 180 HQVRTRIKRS RKLADSNFKD LRTLLNETPE QIKYILAQYN TTKDKAFTDL NSINSVLGGG 240 ILDRLRPNII PVLDEIKSMA TAIKETKEAL ENMNSTLKSL HQQSTQLSSS LTSVKTSLRS 300 SLNDPLCLVH PSSETCNSIR LSLSQLNSNP ELRQLPPVDA ELDNVNNVLR TDLDGLVQQG 360 YQSLNDIPDR VQRQTTTWA GIKRVLNSIG SDIDNVTQRL PIQDILSAFS VYVNNTESYI 420 HRNLPTLEEY DSY WLGGLV ICSLLTLIVI FYYLGLLCGV CGYDRHATPT TRGCVSNTGG 480 VFLMVGVGLS FLFCWILM1I WLTFVFGAN VEKLICEPYT SKELFRVLDT PYLLNED EY 540 YLSGKLFNKS KMKLTFEQVY SDCKKNRGTY GTLHLQNSFN ISEHLNINEH TGSISSELES 600 LKVNLNIFLL GAAGRKNLQD FAACGIDRMN YDSYLAQTGK SPAGVNLLSF AYDLEAKANS 660 LPPGNLRNSL KRDAQTIKTI HQQRVLPIEQ SLSTLYQSVK I QRTGNGLL ERVTRILASL 720 DFAQNFITNN TSSVIIEETK KYGRTIIGYF EHYLQWIEFS ISEKVASCKP VATALDTAVD 780 VFLCSYIIDP LNLFWFGIGK ATVFLLPALI FAVKLAKYYR RMDSEDVYDD VETIPMKNME 840 NGNNGYHKDH VYGIHNPVMT SPSQH
DNA sequence 21
Gene name. G protein-coupled receptor 39
Unigene number- Hs.85339
Nucleic Acid Accession #: NM_0O15O8
Coding sequence. 1-1362 11 21 31 41 51
ATGGCTTCAC CCAGCCTCCC GGGCAGTGAC TGCTCCCAAA, TCATTGATCA CAGTCATGTC 60 CCCGAGTTTG AGGTGGCCAC CTGGATCAAA ATCACCCTTA' TTCTGGTGTA CCTGATCATC 120 TTCGTGATGG GCCTTCTGGG GAACAGCGCC ACCATTCGGG TCACCCAGGT GCTGCAGAAG 180 AAAGGATACT TGCAGAAGGA GGTGACAGAC CACATGGTGA GTTTGGCTTG CTCGGACATC 240 TTGGTGTTCC TCATCGGCAT GCCCATGGAG TTCTACAGCA TCATCTGGAA TCCCCTGACC 300 ACGTCCAGCT ACACCCTGTC CTGCAAGCTG CACACTTTCC TCTTCGAGGC CTGCAGCTAC 360 GCTACGCTGC TGCACGTGCT GACACTCAGC TTTGAGCGCT ACATCGCCAT CTGTCACCCC 420 TTCAGGTACA AGGCTGTGTC GGGACCTTGC CAGGTGAAGC TGCTGATTGG CTTCGTCTGG 480 GTCACCTCCG CCCTGGTGGC ACTGCCCTTG CTGTTTGCCA TGGGTACTGA GTACCCCCTG 540 GTGAACGTGC CCAGCCACCG GGGTCTCACT TGCAACCGCT CCAGCACCCG CCACCACGAG 600 CAGCCCGAGA CCTCCAATAT GTCCATCTGT ACCAACCTCT CCAGCCGCTG GACCGTGTTC 660 CAGTCCAGCA TCTTCGGCGC CTTCGTGGTC TACCTCGTGG TCCTGCTCTC CGTAGCCTTC 720 ATGTGCTGGA ACATGATGCA GGTGCTCATG AAAAGCCAGA AGGGCTCGCT GGCCGGGGGC 780 ACGCGGCCTC CGCAGCTGAG GAAGTCCGAG AGCGAAGAGA GCAGGACCGC CAGGAGGCAG 840 ACCATCATCT TCCTGAGGCT GATTGTTGTG ACATTGGCCG TATGCTGGAT GCCCAACCAG 900 ATTCGGAGGA TCATGGCTGC GGCCAAACCC AAGCACGACT GGACGAGGTC CTACTTCCGG 960 GCGTACATGA TCCTCCTCCC CTTCTCGGAG ACGTTTTTCT ACCTCAGCTC GGTCATCAAC 1020 CCGCTCCTGT ACACGGTGTC CTCGCAGCAG TTTCGGCGGG TGTTCGTGCA GGTGCTGTGC 1080 TGCCGCCTGT CGCTGCAGCA CGCCAACCAC GAGAAGCGCC TGCGCGTACA TGCGCACTCC 1140 ACCACCGACA GCGCCCGCTT TGTGCAGCGC CCGTTGCTCT TCGCGTCCCG GCGCCAGTCC 1200 TCTGCAAGGA GAACTGAGAA GATTTTCTTA AGCACTTTTC AGAGCGAGGC CGAGCCCCAG 1260 TCTAAGTCCC AGTCATTGAG TCTCGAGTCA CTAGAGCCCA ACTCAGGCGC GAAACCAGCC 1320 AATTCTGCTG CAGAGAATGG TTTTCAGGAG CATGAAGTTT GA
Prote sequence 21
Gene name- G protein-coupled receptor 39
Unigene number Hs 85339
Protein Accession # NM_001508, NP_001409
Signal sequence none found
Pfam domains 7tm_l [72-172, 224-344]
Transmembrane domains 32-54, 68-90, 111-133, 151-173, 221-243, 280-301, 320-342
Cellular Localization plasma membrane
1 11 21 31 41 SI
I I I I I I
MASPSLPGSD CSQIIDHSHV PEFEVATWIK ITLILVYLII FVMGLLGNSA TIRVTQVLQK 60
KGYLQKEVTD HMVSLACSD1 LVFLIGMPME FYSIIWNPLT TSSYTLSCKL HTFLFEACSY 120
ATLLHVLTLS FERYIAICHP FRYKAVSGPC QVKLLIGFV VTSALVALPL LFA GTEYPL 180
VNVPSHRGLT CNRSSTRHHE QPETSNMSIC TNLSSR TVF QSSIFGAFW YLWLLSVAF 240
MCWNMMQVLM KSQKGSLAGG TRPPQLRKSE SEESRTARRQ THFLRLIW TLAVCWMPNQ 300
IRRIMAAAKP KHD TRSYFR AY ILLPFSE TFFYLSSVIN PLLYTVSSQQ FRRVFVQVLC 360
CRLSLQHANH EKRLRVHAHS TTDSARFVQR PLLFASRRQS SARRTEKIFL STFQSEAEPQ 420 SKSQSLSLES LEPNSGAKPA NSAAENGFQE HEV
TABLE 8A ABOUT 1260 GENES UP REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT TISSUES
Table 8A lists about 1260 genes up-regulated in glioblastoma compared to normal adult dssues These were selected from 59680 probesets on the Affymelπx Eos Hu03 GeneChip array such that the ratio of "average" glioblastoma to "average" normal adult tissues was greater than or equal to 25 The "average" glioblastoma level was set to the 75th percentile amongst vaπous glioblastoma tumors The "average" normal adult tissue level was set to the 85th percendle amongst vaπous non malignant dssues In order to remove gene- specific background levels of non specific hybridization, the 10th percentile value amongst the non malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated Pkey Unique Eos probeset identifier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene title
R1 Ratio of 75th percendle tumor to 85th percentile normal body dssue
Pkey ExAccn UnigenelD Unigene Title R1
431917 D16181 Hs 2868 peπpheral myelin protein 2 75 2
427343 AI880044 Hs 176977 protein kinase C binding protein 2 746
455601 AI368680 Hs 816 SRY (sex determining region Y) box 2 742
428321 AI699994 Hs 2868 peripheral myelin protein 2 71 6
412719 AW016610 Hs 129911 ESTs 707
449494 AW237014 Hs 315369 Homo sapiens cDNA FU23075 fis, clone L 66 3
415817 U88967 Hs 78867 protein tyrosine phosphatase, receptor-t 643
413472 BE242870 Hs 75379 solute earner family 1 (glial high affi 60 1
456759 BE259150 Hs 127792 delta (Drosophila) like 3 523
435147 AL133731 Hs 4774 Homo sapiens mRNA cDNA DKFZp761C1712 (f 467
425842 A1587490 Hs 159623 NK-2 (Drosophila) homolog B 40 1
412733 AA984472 Hs 74554 KIAA0080 protein 390
418375 NM.003081 Hs 84389 synaptosomal associated protein, 25kD 387
453392 U23752 Hs 32964 SRY (sex determining region Y) box 11 372
423849 AL157425 Hs 133315 Homo sapiens mRNA, cDNA DKFZp761J1324 (f 36 8
413333 M74028 Hs 75297 fibroblast growth factor 1 (acidic) 328
416829 AB013805 Hs 80220 catemπ (cadheπn associated protein), d 31 8
431941 AK000106 Hs 272227 Homo sapiens cDNA FLJ20099 fis, clone CO 31 8
436878 BE465204 Hs 47448 ESTs 31 4
426325 D28114 Hs 169309 myelin associated oligodendrocyte basic 309
425057 AA826434 Hs 1619 achaete scute complex (Drosophila) homol 304
446711 AF169692 Hs 12450 protocadherin 9 302
439415 F05538 Hs 12825 ESTs 283
430838 N46664 Hs 169395 hypothedcal protein FLJ12015 269 429466 M85835 Hs 12827 ESTs 259
447004 A 296968 Hs 157539 ESTs 253
424581 M62062 Hs 150917 catenm (cadheπn-associated protein), a 248
452744 AI267652 Hs 30504 Homo sapiens mRNA, cDNA DKFZp434E082 (fr 248
441285 NM 002374 Hs 167 microtubule-associated protein 2 243
453642 AI370936 Hs 34074 dipepddylpepddase VI 243
424140 Z48051 Hs 141308 myelin oligodendrocyte glycoprotein 242
450133 A 969769 Hs 05201 ESTs 242
408562 AI436323 Hs 31141 Homo sapiens mRNA for KIAA1568 protein, 233
448672 A1955511 Hs 225106 ESTs 227
435708 AI362949 Hs 75169 ESTs 220
407034 U84540 gb Human dystrobrevm isoform DTN 3 (DTN 21 9
407168 R45175 Hs 117183 ESTs 21 7
-131019 NM 005249 Hs 2714 forkhead box GIB 21 5
409049 AI423132 Hs 146343 ESTs 214
433896 AW294729 Hs 274461 ESTs 21 1
445041 T64183 Hs 282982 solute earner 21 0
418738 AW388633 Hs 6682 solute earner family 7, (cadomc ammo 204
444378 R41339 Hs 12569 ESTs 200
411305 BE241596 Hs 69547 myelin basic protein 199
437414 AW894071 Hs 48448 hypothedcal protein DKFZp547C176 198
441016 AW138653 Hs 25845 ESTs 196
440435 AL042201 Hs 21273 transcπption factor NYD-sp10 185
438209 AL120659 Hs 6111 aryl-hydrocarbon receptor nuclear traπsl 184
452461 N78223 Hs 108106 transcπpdon factor 18 1
409395 U46745 Hs 54435 dystrobrevm, alpha 18 1
417183 R52089 Hs 172717 ESTs 180
409638 AW450420 Hs 21335 ESTs 180
428392 H10233 Hs 2265 secretory granule, neuroendocππe protei 180
449611 AI970394 Hs 197075 ESTs 170
446692 Z44514 Hs 156829 Homo sapiens mRNA for KIAA1763 protein, 16 9
425088 AA663372 Hs 169395 hypothetical protein FLJ12015 169
444471 AB020684 Hs 11217 KIAA0877 protein 168
421659 NM 014459 Hs 106511 protocadheπn 17 167
431725 X65724 Hs 2839 Nome disease (pseudoglioma) 166
429276 AF056085 Hs 198612 G protein-coupled receptor 51 166
416892 L24498 Hs 80409 growth arrest and DNA-damage inducible, 165
441440 AI807981 Hs 30495 ESTs 157
449433 AI672096 Hs9012 ESTs, Weakly similar to S26650 DNA-b di 157
421264 AL039123 Hs 103042 microtubule-associated protein 1B 155
415910 U20350 Hs 78913 chemokine (C-X3-C) receptor 1 153
413597 AW302885 Hs 17183 ESTs 151
424945 AI221919 Hs 173438 hypothetical protein FU 10582 149
447414 D82343 Hs 18551 πeuroblastoma (nerve tissue) protein 149
426269 H15302 Hs 168950 Homo sapiens mRNA, cDNA DKFZp566A1046 (f 148
416857 AA188775 Hs 292453 ESTs 147
419721 NM 001650 Hs 288650 aquapoπn 4 146
411078 AI222020 Hs 182364 CocoaCπsp 144
453924 R49295 Hs 24886 ESTs 144
409389 AB007979 Hs 301281 Homo sapiens mRNA, chromosome 1 specific 143
430130 AL137311 Hs 234074 Homo sapiens mRNA, cDNA DKFZp761G02121 ( 141
410909 AW898161 Hs 53112 ESTs, Moderately similar to ALU8 HUMAN A 140
412266 N59006 Hs 26133 ESTs 140
412986 X81120 Hs 5110 cannabinoid receptor 1 (brain) 140
424790 AL119344 Hs 13326 ESTs, Weakly similar to 2004399A chromos 140
439239 A1031540 Hs 235331 ESTs 140
441497 R51064 Hs 23172 ESTs 140
445495 BE622641 Hs 38489 ESTs, Weakly similar to I38022 hypothed 140
414245 BE148072 Hs 75850 WAS protein family, member 1 137
429900 AA460421 Hs 30875 ESTs 136
448595 AB014544 Hs 21572 KIAA0644 gene product 136
449605 AW138581 Hs 198416 ESTs 136
452526 W38537 Hs 280740 hypothedcal protein MGC3040 136
420547 AF155140 Hs 98738 gonadotropin regulated tesdcular RNA he 133
441350 AB020690 Hs 7782 paraπeoplasdc antigen MA2 133
420077 A 512260 Hs 87767 ESTs 132
424120 T80579 Hs 290270 ESTs 132
456965 AW131888 Hs 172792 ESTs, Weakly similar to hypothedcal pro 13 2
423361 AW170055 Hs 47628 ESTs 131
428409 AW117207 Hs 98523 ESTs 129
417160 N76497 Hs 1787 proteolipid protein 1 (Pelizaeυs-Merebac 126
451621 AI879148 Hs 26770 fatty acid binding protein 7, brain 125
411379 AI816344 Hs 12554 ESTs, Weakly similar to NPL4 HUMAN NUCLE 125
436954 AA740151 Hs 130425 ESTs 124
430691 C14187 Hs 103538 ESTs 124
433551 AI985544 Hs 12450 protocadheπn 9 124
422544 AB018259 Hs 118140 KIAA0716 gene product 122
427540 R12014 Hs 20976 ESTs 121
435624 AF218942 Hs 24889 formm 2 121
415849 R20529 Hs 6806 ESTs 121
428845 AL157579 Hs 153610 KIAA0751 gene product 119
442671 AI005668 Hs 134779 EST 11 9
444396 T65213 Hs 4257 ESTs 11 8 452752 AW044058 Hs 33578 KIAA0820 protein 11 8
425523 AB007948 Hs 158244 KIAA0479 protein 11 8
416072 AL110370 Hs 79000 growth associated protein 43 11 7
440184 AB002297 Hs 7022 dedicator of cyto-kinesis 3 11
428976 AL037824 Hs 194695 ras homolog gene family, member I 11 6
444783 AK001468 Hs 62180 amllin (Drosophila Scraps homolog), act 11 6
448299 AA497044 Hs 20887 hypothedcal protein FLJ 10392 11 6
414214 049958 Hs 75819 glycoprotein M6A 11 5
428982 NM.005097 Hs 194704 leucme-πch, glioma inacdvated 1 11 5
405238 11 4
420362 U79734 Hs 97206 hundnglin interacting protein 1 11 4
422980 N46569 Hs 76722 CCAAT/eπhancer binding protein (C/EBP), 11 4
424918 R13982 Hs 169309 myelin associated oligodendrocyte basic 11 4
434277 X77748 Hs 3786 glutamate receptor, metabotropic 3 11 4
451952 AL120173 Hs 301663 ESTs 11 3
408829 NM.006042 Hs 48384 heparan sulfate (glucosamme) 3-O-sulfot 11 3
424278 AK000723 Hs 144517 hypothetical protein FLJ20716 11 3
429418 AI381028 Hs 118769 ESTs 11 3
429918 AW873986 Hs 119383 ESTs 11 3
443912 R37257 Hs 184780 ESTs 11 3
448743 AB032962 Hs 21896 KIAA1136 protein 11 3
420092 AA814043 Hs 88045 ESTs 11 2
408081 AW451597 Hs 167409 ESTs 11 2
411642 NM 014932 Hs 71132 neuralig 1 109
415170 R44386 Hs 164578 ESTs 109
426320 W47595 Hs 169300 transforming growth factor, beta 2 108
450568 AL050078 Hs 25159 Homo sapiens cDNA FU10784 fis, clone NT 108
425799 T08133 Hs 182906 Homo sapiens mRNA for KIAA1872 protein, 108
423853 AB011537 Hs 133466 slit (Drosophila) homolog 1 107
400293 N51002 Hs 306480 Homo sapiens mRNA, cDNA DKFZp761 E2112 (f 107
447773 AI423930 Hs 36790 ESTs, Weakly similar to putadve p150 [H 107
448321 NM 005883 Hs 20912 adenomatous polyposis cod like 105
448533 AL119710 Hs 21365 nucleosome assembly protein 1-lιke 3 105
440684 AI253123 Hs 127356 ESTs, Highly similar to S21424 nesdn [H 103
444017 U04840 Hs 214 neuro-oncological ventral antigen 1 103
438380 T06430 Hs 6194 chondroidn sulfate proteoglycan BEHAB/b 103
440471 AA886146 Hs 307944 ESTs 102
413063 AL035737 Hs 75184 chitmase 3-lιke 1 (cartilage glycoprote 101
439978 BE139460 Hs 124673 Homo sapiens cDNA FLJ 11477 fis, clone HE 10 1
448902 Z45998 Hs 22543 Homo sapiens mRNA, cDNA OKFZp761l1912 (f 101
424932 R14070 Hs 315369 Homo sapiens cDNA FLJ23075 fis, clone L 99
431721 AB032996 Hs 268044 KIAA1170 protein 99
419088 AI538323 Hs 52620 mtegπn, beta 8 98
420602 AF060877 Hs 99236 regulator of G-protem signalling 20 98
436511 AA721252 Hs 291502 ESTs 98
414696 AF002020 Hs 76918 Niemanπ Pick disease, type C1 97
449539 W80363 Hs 58446 ESTs 97
412959 D87458 Hs 75090 KIAA0282 protein 96
412811 H06382 Hs 21400 ESTs 96
449300 AI656959 Hs 222165 ESTs 96
426344 H41821 Hs 322469 transcnpdonal activator of the c fos p 95
419271 N34901 Hs 238532 ESTs 95
419078 M93119 Hs 89584 insulmoma-associated 1 94
451516 AI800515 Hs 12024 ESTs 94
422656 AI870435 Hs 1569 LIM homeobox protein 2 93
449318 AW236021 Hs 78531 Homo sapiens, Similar to RIKEN cDNA 5730 93
414175 AI308876 Hs 103849 hypothetical protein DKFZp761D112 93
415279 F04237 Hs 1447 glial fibπllaiy acidic protein 92
428784 Y12851 Hs 193470 puπnergic receptor P2X, ligand gated 10 92
429903 AL134197 Hs 93597 cyclin-dependent kinase 5, regulatory su 92
424641 AB001106 Hs 161413 giia maturadon factor, beta 9 1
417435 NM 005181 Hs 82129 carbonic anhydrase III, muscle specific 9 1
449448 D60730 Hs 57471 ESTs 91
408508 A1806109 Hs 135736 KIAA1580 protein 90
452785 AL359942 Hs 296434 erythroid differentiation and denucleati 90
448986 H42169 Hs 18653 hypothetical protein FLJ14627 89
447072 D61594 Hs 17279 tyrosylprotem sulfotransferase 1 89
433800 AI034361 Hs 135150 lung type-1 cell membrane associated gly 89
408926 AF217525 Hs 49002 Down syndrome cell adhesion molecule 88
449625 NM 014253 Hs 23796 odz (odd Oz ten m, Drosophila) homolog 1 88
400292 AA250737 Hs 72472 ESTs 87
417404 NM.007350 Hs 82101 pleckstπn homology-like domain, family 87
420345 AW295230 Hs 25231 ESTs 87
429927 NM 001115 Hs 2522 adenylate cyclase 8 (brain) 87
437528 N59646 Hs 169745 crumbs (Drosophila) homolog 1 87
440152 AB002376 Hs 7006 KIAA0378 protein 87
451099 R52795 Hs 25954 interieukin 13 receptor, alpha 2 86
400780 86
434891 AA814309 Hs 123583 ESTs 86
449277 AA001064 Hs 172976 ESTs 86
415709 AA649850 Hs 278558 ESTs 85
439947 AB006627 Hs 6788 astrotacdn 85
447197 R36075 gb yh88b01 s1 Soares placenta Nb2HP Homo 85 433042 AW193534 Hs 281895 Homo sapiens cDNA FLJ11660 fis, clone HE 84
416370 N90470 Hs 203697 ESTs, Weakly similar to I38022 hypotheti 84
452786 R61362 Hs 106642 ESTs, Weakly similar to T09052 hypotheti 84
415796 R87548 Hs 78854 ATPase, Na+/K+ transporting, beta 2 poly 83
426271 AF026547 Hs 169047 chondroidn sulfate proteoglycan 3 (πeur 83
408947 AL080093 Hs 49117 Homo sapiens mRNA, cDNA DKFZp564N1662 (f 83
419863 AW952691 Hs 93485 Homo sapiens mRNA, cDNA DKFZp761D191 (fr 83
433447 U29195 Hs 3281 neuronal pentraxm II 83
431467 N71831 Hs 256398 Homo sapiens mRNA, cDNA DKFZp434E0528 (f 83
409327 L41162 Hs 53563 collagen, type IX, alpha 3 83
414300 AI304870 Hs 188680 ESTs 82
407728 AW071502 Hs 175931 ESTs 82
422798 R92347 Hs 34574 ESTs, Weakly similar to ALU1 HUMAN ALU S 82
419704 AA429104 Hs 45057 ESTs 82
429007 D80642 gb HUM092E09B Human fetal brain (TFujiwa 8 1
442710 AI015631 Hs 23210 ESTs 8 1
425048 H05468 Hs 164502 ESTs 81
429149 AW193360 Hs 197962 ESTs, Weakly similar to I38022 hypothed 80
445740 T78281 Hs 13226 Homo sapiens clone 25181 mRNA sequence 80
418771 AA807881 Hs 25329 ESTs 79
422728 AW937826 Hs 103262 ESTs, Weakly similar to ZN91.HUMAN ZINC 79
425984 AW836277 Hs 165636 hypothedcal protein DKFZp76ΪC07121 79
448408 AA322866 Hs 21107 neuroligm 79
455364 H72176 Hs 4273 hypothetical protein FU13159 79
446619 AU076643 Hs 313 secreted phosphoprotein 1 (osteopondπ, 79
435501 AW051819 Hs 129908 KIAA0591 protein 78
423600 AI633559 Hs 310359 ESTs 78
450625 AW970107 gb EST382188 MAGE resequences, MAGK Homo 78
415314 N88802 Hs 5422 glycoprotein M6B 77
420036 R60336 Hs 52792 Homo sapiens mRNA, cDNA DKFZp586l1823 (f 77
427687 AW003867 Hs 1570 histam e receptor H1 77
449328 AI962493 Hs 197647 ESTs 77
419249 X14767 Hs 89768 gamma-aminobutync acid (GABA) A recepto 77
407896 D76435 Hs 41154 Zic family member 1 (odd paired Drosophi 77
419103 Z40229 Hs 96423 hypothetical protein FU23033 76
438779 NM.003787 Hs 6414 nucleolar protein 4 76
433532 AW975367 gb EST387475 MAGE resequences, MAGN Homo 76
448555 AI536697 Hs 159863 ESTs 75
439662 H97552 Hs 269060 ESTs 75
448543 AW897741 Hs 21380 Homo sapiens mRNA, cDNA DKFZp586P1124 (f 75
410099 AA081630 Hs 169387 KIAA0036 gene product 75
431592 R69016 Hs 213194 hypothetical protein MGC10895 74
409731 AA125985 Hs 56145 thymosin, beta, identified in neuroblast 74
405819 74
407886 AW969688 Hs 100826 ESTs 74
437416 AL359605 Hs 283851 Homo sapiens mRNA, cDNA DKFZp547G036 (fr 74
437698 R61837 Hs 7990 ESTs, Moderately similar to 184505 calci 74
408604 D51408 Hs 21925 ESTs 74
418506 AA084248 Hs 85339 G protein-coupled receptor 39 73
447499 AW262580 Hs 147674 protocadheπnbeta 16 73
454036 AA374756 Hs 93560 Homo sapiens mRNA for KIAA1771 protein, 73
409746 NM 004794 Hs 56294 RAB33A, member RAS oncogene family 72
410037 AB020725 Hs 58009 KIAA0918 protein 72
419318 AW969742 Hs 291005 ESTs 72
424051 AL110203 Hs 138411 Homo sapiens mRNA, cDNA DKFZp586J1922 (f 72
442026 AI243749 Hs 8074 brain-specific angiogenesis inhibitor 3 72
448243 AW369771 Hs 52620 integπn, beta 8 72
436281 AW411194 Hs 85195 myeloid leukemia factor 1 72
426429 X73114 Hs 169849 myosin-binding protein C, slow-type 72
407182 AA312551 Hs 230157 ESTs 71
415293 R49462 Hs 106541 ESTs 71
422764 AI767727 Hs 47522 ESTs 7 1
451592 AI805416 Hs 213897 ESTs 7 1
429469 M64590 Hs 27 glycine dehydrogenase (decarboxyladng, 70
415734 NM 014747 Hs 78748 KIAA0237 gene product 70
434149 Z43829 Hs 19574 hypothetical protein MGC5469 70
436726 AA324975 Hs 128993 ESTs, Weakly similar to T00079 hypotheti 70
417632 R20855 Hs 5422 glycoprotein M6B 70
422421 AA325138 Hs 235873 hypothedcal protein FLJ22672 69
435267 N23797 Hs 110114 ESTs 69
437117 AL049256 Hs 122593 ESTs 69
445523 Z30118 Hs 293788 ESTs, Moderately similar to unnamed prot 69
445900 AF070526 Hs 13429 Homo sapiens clone 24787 mRNA sequence 69
445745 AB007924 Hs 13245 KIAA0455 gene product 69
424085 NM 002914 Hs 139226 replicadoπ factor C (activator 1) 2 (40 69
428588 F12101 Hs 185701 Homo sapiens mRNA full length insert cDN 68
421723 AA620400 Hs 300717 sodium channel, voltage-gated, type III, 68
447342 AI199268 Hs 19322 Homo sapiens, Similar to RIKEN cDNA 2010 67
443297 AI049864 Hs 133029 ESTs 67
443992 AW022228 Hs 322922 ESTs 67
453096 AW294631 Hs 11325 ESTs 67
453857 AL080235 Hs 35861 DKFZP586E1621 protein 67
443761 AI525743 Hs 160603 ESTs 66 429609 AF002246 Hs 210863 cell adhesion molecule with homology to 66
435056 AW023337 Hs 5422 glycoprotein M6B 65
453431 AF094754 Hs 32973 glycine receptor, beta 65
444190 AI878918 Hs 10526 cysteine and glycme-πch protein 2 65
418110 R43523 Hs 217754 hypothedcal protein FLJ22202 65
413988 M81883 Hs 324784 glutamate decarboxylase 1 (brain, 67kD) 65
420805 L10333 Hs 99947 . . redculon 1 64
429125 AA446854 Hs 271004 ESTs, Weakly similar to I38022 hypothed 64
435256 AF193766 Hs 13872 cytokine-like protein C17 64
407866 AW088232 Hs 89506 paired box gene 6 (amπdia, keradds) 63
440700 AW952281 Hs 296184 guanine nucleotide binding protein (G pr 63
427701 AA411101 Hs 243886 nuclear autoantigenic sperm protein (his 63
422949 AA319435 gb EST21657 Adrenal gland tumor Homo sap 62
445102 AW204610 Hs 22270 ESTs 62
452401 NM 007115 Hs 29352 tumor necrosis factor, alpha-induced pro 62
435538 AB011540 Hs 4930 low density lipoprotein receptor-related 62
410102 AW248508 Hs 279727 Homo sapiens cDNA FLJ14035 fis, clone HE 62
416871 H98716 gb yx13d08 s1 Soares melanocyte 2NbHM Ho 6 1
416702 AA186428 Hs 85591 ESTs 6 1
419347 C15944 Hs 90005 supeπorcervical ganglia, neural specifi 61
424997 AL138167 Hs 96920 ESTs 61
438660 U95740 Hs 6349 Homo sapiens, clone IMAGE 3010666, mRNA, 61
453649 Y07494 Hs 34114 ATPase, Na+/K+ transporting, alpha 2 (+) 61
449444 AW818436 Hs 23590 solute earner family 16 (monocarboxylic 61
414117 W88559 Hs 1787 proteolφid protein 1 (Pelizaeus-Merzbac 60
425517 AF121179 gb AF121179 Homo sapiens liver (Chang L- 60
427457 AW779105 Hs 164682 ESTs 60
437034 AA742643 gb πy91c01 s1 NCI CGAP.GCB1 Homo sapiens 60
444170 AW613879 Hs 102408 ESTs 60
457183 H91882 Hs 118569 Dvl-biπdmg protein IDAX (inhibidon of 60
448999 AF179274 Hs 22791 transmembrane protein with EGF-like and 60
454048 H05626 Hs 6921 ESTs 60
439772 AL365406 Hs 10268 Homo sapiens mRNA full length insert cDN 59
448944 AB014605 Hs 22599 atrophm 1 interacting protein 1, acdvi 59
410011 AB020641 Hs 57856 PFTAIRE protein kinase 1 59
415486 H12214 Hs 13284 ESTs, Weakly similar to 2109260A B cell 59
438993 AA828995 gb od77b08 s1 NCI CGAP Ov2 Homo sapiens 59
447350 AI375572 Hs 172634 ESTs 59
451783 R42554 Hs 210862 T-box, brain, 1 59
447101 N72185 Hs 44189 ESTs 59
440492 R39127 Hs 21433 hypothetical protein DKFZp547J036 59
440274 R24595 Hs 7122 scrapie responsive protein 1 59
438461 AW075485 Hs 286049 phosphoseπne aminotransferase 59
418064 BE387287 Hs 83384 S100 calcium binding protein, beta (neur 58
437036 AI571514 Hs 133022 ESTs 57
412225 AW902042 gb QV0-NN1O22-17040O-19.--C02 NN1022 Homo 57
426342 AF093419 Hs 169378 multiple PDZ domain protein 57
444218 AF070641 Hs 10684 Homo sapiens clone 24421 mRNA sequence 57
445828 F05802 Hs 81907 ESTs 57
447198 D61523 Hs 283435 ESTs 57
427897 NM 017413 Hs 303084 apelin, pepdde ligand for APJ receptor 57
448499 BE613280 Hs 77550 hypothetical protein MGC1780 57
443672 AA323362 Hs 9667 butyrobetaiπe (gamma), 2-oxoglutarate di 56
412155 R38167 Hs 12449 Homo sapiens transmembrane protein HTMP1 56
435718 R06569 Hs 269534 ESTs 56
449340 AW235786 Hs 195359 hypothedcal protein MGC10954 56
424481 R19453 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbac 56
451996 AW514021 Hs 245510 ESTs 56
422411 AW749443 Hs 22511 ESTs 56
438328 AI492261 Hs 32450 ESTs 56
433244 AB040943 Hs 271285 KIAA1510 protein 56
435191 R15912 Hs 4817 Homo sapiens clone 24461 mRNA sequence 55
418677 S83308 Hs 87224 SRY (sex determining region Y)-box 5 55
400859 55
413625 AW451103 Hs 71371 ESTs 55
421863 AI952677 Hs 108972 Homo sapiens mRNA, cDNA DKFZp434P228 (fr 55
434933 R91095 Hs 4276 KIAA1701 protein 55
438702 AI879064 Hs 54618 ESTs 55
452055 AI377431 Hs 141693 hypothetical protein MGC10858 55
430979 AI479755 Hs 129010 ESTs 55
412709 AL022327 Hs 74518 KIAA0027 protein 55
439920 H05430 Hs 288433 neurotπmin 55
424343 AW956360 Hs 4748 adenylate cyclase activating polypeptide 54
407846 AA426202 Hs 40403 Cbp/p300-ιnteracdng transactivator, wit 54
419235 AW470411 Hs 288433 πeurotπmin 54
418030 BE207573 Hs 83321 neuromedin B 54
410330 AW023630 Hs 46786 ESTs 54
410781 AI375672 Hs 165028 ESTs 54
420658 AW965215 Hs 336656 ESTs 54
421308 AA687322 Hs 192843 leucine zipper protein FKSG14 54
443740 R56434 Hs 21062 ESTs 54
426457 AW894667 Hs 169965 chimeππ (chimaenn) 1 54
450375 AA009647 Hs 8850 a disiπtegπn and metalloprotemase doma 54 412494 AL133900 Hs 792 ADP-πbosylatioπ factor domain protein 1 54
426600 NM.003378 Hs 171014 VGF nerve growth factor inducible 54
424432 AB037821 Hs 146858 protocadheπn 10 54
429250 H56585 Hs 198308 tryptophan nch basic protein 54
443785 AW449952 Hs 190125 basic helix loop-helix PAS protein 54
436282 R91913 Hs 272104 ESTs, Moderately similar to ALU1.HUMAN A 54
404584 53
430091 AB032958 Hs 233023 KIAA1132 protein 53
439845 AL355743 Hs 56663 Homo sapiens EST from clone 41214, full 53
424001 W67883 Hs 137476 paternally expressed 10 53
425073 W39609 Hs 22003 solute earner family 6 (neurotransmitte 53
426625 T78300 Hs 300642 serologically defined colon cancer andg 53
428137 AA421792 Hs 170999 ESTs 53
428679 AA431765 gb zw80c03 s1 Soares tesds NHT Homo sap 53
438176 AW138970 Hs 122113 ESTs 53
440138 AB033023 Hs 318127 hypothedcal protein FLJ10201 53
451018 AW965599 Hs 247324 mitochoπdπal πbosomal protein S14 53
416340 N31772 Hs 79226 fasciculation and elongation protein zet 53
435244 N77221 Hs 187824 ESTs 53
446035 NM.006558 Hs 13565 Sam68-lιke phosphotyrosine protein, T-ST 53
424624 AB032947 Hs 151301 Ca2- lepeπdent acdvator protein for sec 53
407748 AL079409 Hs 38176 KIAA0606 protein, SCN Orcadian Oscillat 53
430437 AI768801 Hs 169943 Homo εapieπs cDNA FLJI 3569 fis, clone PL 53
414825 X06370 Hs 77432 epidermal growth factor receptor (avian 52
453941 U39817 Hs 36820 Bloom syndrome 52
424998 U58515 Hs 154138 chitmase 3-lιke 2 52
423419 R55336 Hs 23539 ESTs 52
424922 BE386547 Hs 217112 hypothedcal protein MGC10825 52
447359 NM.012093 Hs 18268 adenylate kinase 5 52
408206 AF041853 Hs 43670 kmesin family member 3A 52
421013 M62397 Hs 1345 mutated in colorectal cancers 52
429443 AB028967 Hs 202687 potassium voltage-gated channel, Shal re 52
434367 AB020700 Hs 3830 KIAA0893 protein 52
444861 R46789 Hs 76118 ubiquitin carboxyl terminal esterase L1 52
446142 AI754693 Hs 145968 ESTs 52
448816 AB033052 Hs 22151 KIAA1226 protein 52
451050 AW937420 Hs 69662 ESTs 52
451106 BE382701 Hs 25960 v-myc avian myelocytomatosis viral relat 52
439285 AL133916 Hs 172572 hypothetical protein FLJ20093 52
416737 AF154335 Hs 79691 LIM domain protein 52
424800 AL035588 Hs 153203 MyoD family inhibitor 52
443695 AW204099 Hs 337720 ESTs, Weakly similar to AF1267801 re n 52
415257 F03016 Hs 27513 ESTs 52
433929 AI375499 Hs 27379 ESTs 51
415651 AI207162 Hs 3815 stathmm like protein RB3 5 1
451027 AW519204 Hs 40808 ESTs 51
409172 Z99399 Hs 118145 ESTs 5 1
423343 AA324643 Hs 246106 ESTs 5 1
429172 AA447417 Hs 285491 ESTs 51
437268 AI754847 Hs 227571 regulator of G-protem signalling 4 5 1
451270 AW341392 Hs 235795 ESTs 5 1
452904 AL157581 Hs 30957 Homo sapiens mRNA, cDNA DKFZp434E0626 (f 51
420560 AW207748 Hs 59115 ESTs 5 1
418097 R45137 Hs 21868 ESTs 51
442910 AI365130 Hs 11307 ESTs Weakly similar to T19326 hypotheti 51
434849 AW292765 Hs 8053 ESTs 5 1
413554 AA319146 Hs 75426 secretogranin II (chromogranin C) 51
414217 AI309298 Hs 279898 Homo sapiens cDNA FU23165 fis clone L 5 1
412068 S72043 Hs 73133 metallothionem 3 (growth inhibitory fac 50
413627 BE182082 Hs 246973 ESTs 50
418661 NM 001949 Hs 1189 E2F transcnpdon factor 3 50
422438 AA445925 Hs 270896 ESTs, Moderately similar to Z195.HUMAN Z 50
423728 AW891294 Hs 132136 solute carrier family 4, sodium bicarbon 50
431431 AL096711 Hs 252953 Human DNA sequence from clone RP3-403A15 50
435087 AW975241 Hs 23567 ESTs 50
452097 AB002364 Hs 27916 a dismtegππ like and melalloprotease ( 50
410434 AF051152 Hs 63668 toll like receptor 2 49
408692 AL040127 Hs 34074 dipeptidylpepddaseVI 49
407808 AA663559 Hs 279789 histone deacetylase 3 49
418940 H17739 Hs 288513 Human DNA sequence from clone RP5-899C14 49
425977 R15138 Hs 165570 Homo sapiens clone 25052 mRNA sequence 49
426814 AF036943 Hs 172619 myelin transcnpdon factor 1 like 49
447112 H17800 Hs 7154 ESTs 49
449574 F05048 Hs 175373 ESTs 49
453652 AW009640 Hs 28368 ESTs Moderately similar to S65657 alpha 49
423869 BE409301 Hs 134012 C1q related factor 49
413248 T64858 Hs 21433 hypothetical protein DKFZp547J036 49
449176 AI633545 Hs 198072 ESTs 49
448451 AW015994 gb Ul H BlOp-abh-g 09 0 Ul s1 NCI.CGAP.S 48
402604 48
436039 AW023323 Hs 121070 ESTs 48
448769 N66037 Hs 38173 ESTs 48
423678 AW963357 Hs 7847 ESTs 48 439451 AF086270 Hs 278554 I heterochromatin like protein 1 48
425870 R13406 Hs 56782 I ESTs 48
408777 U71204 Hs47626 I Ric (Drosophila) like expressed in πeur 48
413409 AI638418 Hs78580 DEAD/H (Asp-Glu Ala-Asp/His) box polypep 48
413623 AA825721 Hs 246973 ESTs 48
417246 AI760098 Hs 21411 ESTs 48
420900 AL045633 Hs 44269 ESTs 48
424153 AA451737 Hs 141496 MAGE like 2 48
443539 AI076182 Hs 134074 ESTs, Moderately similar to ALU6.HUMAN A 48
448750 U95020 Hs 21903 calcium channel, voltage-dependent, beta 48
454030 AW021429 Hs 231980 ESTs 48
424458 M29273 Hs 1780 myelin associated glycoprotein 48
444119 R41231 Hs 184261 ESTs, Weakly similar to T26686 hypothed 48
407792 AI077715 Hs 39384 putative secreted ligand homologous to f 48
431462 AW583672 Hs 256311 graniπ like neuroendocππe peptide precu 47
431103 M57399 Hs44 pleiotrophin (hepann binding growth fac 47
429956 AI374651 Hs 22542 ESTs 47
435060 AI422719 Hs 233349 ESTs, Weakly similar to fork head like p 47
436203 BE384982 Hs5076 Homo sapiens cDNA FLJ22128 fis, clone H 47
448475 BE613134 Hs 247474 hypothetical protein FLJ21032 47
422222 AI699372 Hs 193247 hypothetical protein DKFZp434A171 47
431733 AW298410 Hs 21475 ESTs 47
449353 AA001220 Hs 271369 ESTs 47
452022 AW072330 Hs 293875 ESTs 47
454269 AI961060 Hs 129908 KIAA0591 protein 47
404541 47
428189 AA424030 Hs 46627 ESTs 47
409125 R17268 Hs 259873 axonal transport of synaptic vesicles 47
458435 AI418718 Hs 144121 ESTs, Weakly similar to T46916 hypothed 46
425745 U44060 Hs 14427 Homo sapiens cDNA FLJ21800 fis, clone H 46
413492 D87470 Hs75400 KIAA0280 protein 46
419629 AB020695 Hs 91662 KIAA0888 protein 46
407638 AJ404672 Hs 334483 hypothedcal protein FLJ23571 46
436140 W87355 Hs269587 ESTs 46
439169 AI912122 Hs 41095 ESTs 46
443150 AI034467 Hs 34650 ESTs 46
451073 AI758905 Hs 206063 ESTs 46
451659 BE379761 Hs 14248 ESTs 46
452106 AI141031 Hs 21342 ESTs 46
451407 AA131376 Hs 326401 fibroblast growth factor 12B 46
448765 R15337 Hs 21958 Homo sapiens mRNA, cDNA DKFZp547D086 (fr 46
430147 R60704 Hs 234434 hairy/enhancer-of split related with YRP 46
437204 AL110216 Hs 12285 ESTs, Weakly similar to 155214 salivary 46
431117 AF003522 Hs 250500 delta (Drosophila) like 1 45
422175 N79885 Hs6382 ESTs Highly similar to T00391 hypotheti 45
407889 R34556 Hs 30800 ESTs, Weakly similar to S65657 alpha-1 C- 45
419343 AA456245 Hs 85603 down regulated by Ctπnbl, a 45
421790 AW896201 Hs 22654 sodium channel, voltage gated type I, a 45
429399 AA452244 Hs 16727 ESTs 45
450149 AW969781 Hs 132863 Zic family member 2 (odd paired Drosophi 45
453118 AW195849 Hs 252757 ESTs 45
443455 AB001025 Hs 9349 ryanodine receptor 3 44
442613 AI004002 Hs 130522 Kv channel interacting protein 1 44
429643 AA455889 Hs 167279 FYVE-finger-contain g Rab5 effector pro 44
416209 AA236776 Hs 79078 MAD2 (mitotic arrest deficient, yeast h 44
418845 AA852985 Hs 89232 chromobox homolog 5 (Drosophila HP1 alph 44
435202 AI971313 Hs 170204 KIAA0551 protein 44
437496 AA452378 Hs 170144 Homo sapiens mRNA, cDNA DKFZp547J125 (fr 44
451254 AI571016 Hs 172967 ESTs 44
439039 AI656707 Hs48713 ESTs 44
439979 AW600291 Hs6823 hypothetical protein FLJ10430 44
441607 NM 005010 Hs7912 neuronal cell adhesion molecule 44
424983 AI742434 Hs 169911 ESTs 44
410611 AW954134 Hs20924 KIAA1628 protein 44
402605 44
409248 AB033035 Hs 51965 KIAA1209 protein 44
442222 AI061301 Hs 164773 ESTs 44
454027 R40192 Hs 21527 Human DNA sequence from clone GS1-115M3 44
454293 H49739 Hs 134013 ESTs Moderately similar to HK61 HUMAN H 44
442832 AW206560 Hs 253569 ESTs 44
407304 AA565832 gb nj32b03 s1 NCI CGAP AA1 Homo sapiens 44
423279 AW959861 Hs 290943 ESTs 43
427194 AA399018 Hs 250835 ESTs 43
419723 AL120193 Hs 92614 longevity assurance (LAG1 , S cerevisiae 43
445810 AW265700 Hs 155660 ESTs 43
409734 BE161664 Hs 56155 hypothetical protein 43
410389 AW954049 Hs 8177 ESTs Weakly similar to PIHUB6 salivary 43
411571 AA122393 Hs 70811 hypothedcal protein FLJ20516 43
433024 AA573847 Hs26549 KIAA1708 protein 43
453202 AW085781 Hs 26270 hypothedcal protein FLJ 11588 43
425264 AA353953 Hs 20369 ESTs Weakly similar to gonadotropin ind 43
416427 BE244050 Hs 79307 Rac/Cdc42 guanine exchange factor (GEF) 43
431789 H19500 Hs 269222 mitogen activated protein kinase 4 43 444600 R41398 Hs 6996 ESTs 43
454042 H22570 Hs 172572 hypothetical protein FLJ20093 43
441899 AI372588 Hs 8022 TU3A protein 43
425256 BE297611 Hs 155392 collapsin response mediator protein 1 43
410358 AW975168 Hs 13337 ESTs, Weakly similar to unnamed protein 42
430291 AV660345 Hs 238126 CGI 49 protein 42
433597 AA708205 Hs 100343 ESTs 42
444127 N63620 Hs 13281 ESTs 42
448507 AL133109 Hs 21333 Homo sapiens mRNA, cDNA DKFZp566N1047 (f 42
413589 AW452631 Hs 313803 ESTs, Highly similar to AF157833 1 noπcl 42
408577 H50572 Hs 19515 ESTs, Highly similar to NRG3.HU AN PRO-N 42
409719 AI769160 Hs 108681 Homo sapiens brain tumor associated prot 42
428536 AI143139 Hs 2288 vismin like 1 42
429118 H20669 Hs 35406 ESTs, Highly similar to unnamed protem 42
432865 AI753709 Hs 152484 ESTs, Weakly similar to 138022 hypothed 42
447138 AI439112 Hs 93828 ESTs, Weakly similar to 2109260A B cell 42
450648 AI703366 Hs 26766 ESTs 42
451459 AI797515 Hs 270560 ESTs, Moderately similar to ALU7.HUMAN A 42
421686 AB011156 Hs 106794 KIAA0584 protein 42
452776 AA194540 Hs 13522 ESTs, Weakly similar to I38022 hypothed 42
436421 AI678031 Hs 122813 ESTs, Weakly similar to ZN22.HUMAN ZINC 42
423858 AL137326 Hs 133483 Homo sapiens mRNA, cDNA DKFZp434B0650 (f 42
434001 AW950905 Hs 3697 senne (or cysteine) proteinase mhibito 42
437380 AL359577 Hs 112198 Homo sapiens mRNA, cDNA DKFZp547M073 (fr 42
432328 AI572739 Hs 195471 6-phosphofructo-2-kιnase/fructose-2,6-bι 41
439607 BE540565 Hs 159460 ESTs 41
424028 AF055084 Hs 153692 Homo sapiens cDNA FLJ14354 fis, clone Y7 41
446936 H10207 Hs 47314 ESTs 41
424240 AB023185 Hs 143535 calcium/calmodulin-dependent protein km 41
412446 AI768015 Hs 92127 ESTs 41
409953 AA332277 Hs 57691 cadheπn 18, type 2 41
416220 N49776 Hs 170994 hypothedcal protein MGC10946 41
419683 AA248897 Hs 48784 ESTs 4 1
426071 AW138057 Hs 163835 ESTs 4 1
428743 AL080060 Hs 301549 Homo sapiens mRNA, cDNA DKFZp564H172 (fr 41
432809 AA565509 Hs 131703 ESTs 41
440105 AA694010 Hs 6932 Homo sapiens clone 23809 mRNA sequence 41
452039 A1922988 Hs 172510 ESTs 41
425905 AB032959 Hs 318584 novel C3HC4 type Zinc finger (πng finge 41
457561 AA331517 Hs 286055 chimenn (chimaeπn) 2 41
429038 AL023513 Hs 194766 seizure related gene 6 (mouse)-lιke 41
433932 AW954599 Hs 169330 neuronal protein 41
436637 AI783629 Hs 26766 ESTs 4 1
439231 AW581935 Hs 141480 Homo sapiens mRNA, cDNA DKFZp434N079 (fr 4 1
450530 NM 006668 Hs 25121 cytochrome P450, subfamily 46 (cholester 41
407721 Y12735 Hs 38018 dual specificity tyrosme-(Y) phosphoryl 4 1
407881 AW072003 Hs 40968 heparan sulfate (glucosamine) 3-O-sulfot 41
410486 AW235094 Hs 69233 zinc finger protein 40
413916 N49813 Hs 75615 apolipoproteiπ C-ll 40
438703 AI803373 Hs 31599 ESTs 40
424726 AK001007 Hs 138760 Homo sapiens cDNA FLJ10145 fis, clone HE 40
405771 40
418841 NM 002332 Hs 89137 low density lipoprotein related protem 40
421764 AI681535 Hs 148135 seπne/threonine kinase 33 40
424176 AL137273 Hs 142307 hypothetical protein 40
425773 N21279 Hs 237749 ESTs 40
427304 AA761526 Hs 163853 ESTs 40
428882 AA436915 Hs 131748 ESTs, Moderately similar to ALU7.HUMAN A 40
452834 AI638627 Hs 105685 KIAA1688 protein 40
453745 AA952989 Hs 63908 hypothedcal protein MGC14726 40
405239 U89281 Hs 11958 oxidative 3 alpha hydroxysteroid dehydro 40
413801 M62246 Hs 35406 ESTs, Highly similar to unnamed protein 40
429698 AI685086 Hs 26339 ESTs, Weakly similar to S21348 probable 40
435854 AJ278120 Hs 4996 putative aπkyπn repeat containing prate 40
439199 R40373 Hs 26299 ESTs 40
439450 R51613 Hs 125304 ESTs 40
446782 AI653048 Hs 144006 ESTs 40
419687 AI638859 Hs 227699 ESTs, Weakly similar to T2D3.HUMAN TRANS 39
402408 39
453362 H14988 Hs 107375 ESTs 39
414219 W20010 Hs 75823 ALL1-fused gene from chromosome 1q 39
420578 AA813546 Hs 99034 GTP-binding protein Rho7 39
425010 T16837 Hs 4241 ESTs 39
444230 H95537 Hs 146067 ESTs 39
441736 AW292779 Hs 169799 ESTs 39
418951 F07809 Hs 89506 paired box gene 6 (anindia, keratitis) 39
406311 39
408460 AA054726 Hs 285574 ESTs 39
410658 AW105231 Hs 192035 ESTs 39
414699 AI815523 Hs 76930 synuclein, alpha (non A4 component of am 39
418849 AW474547 Hs 53565 Homo sapiens PIG-M mRNA for mannosyltran 39
429477 AI275514 Hs 6658 ESTs 39
433766 AA609234 Hs 112669 ESTs 39 436190 AK001059 gb Homo sapiens cDNA FLJ10197 fis, clone 39
447891 R41754 Hs 6496 ESTs 39
450221 AA328102 Hs 24641 ( cytoskeleton associated protein 2 39
404283 39
453919 AW959912 Hs7076 KIAA1705 protein 39
429656 X05608 Hs 211584 neurofilament light polypepdde (68kD) 39
412754 AW160375 Hs74565 amyloid beta (A4) precursor-like protein 39
445314 AI689948 Hs65489 Homo sapiens cDNA FLJ21517 fis, clone C 39
435652 N32388 Hs 334370 uπcharactenzed hypothalamus protein HBE 39
407378 AA299264 Hs57776 ESTs, Moderately similar to 138022 hypot 39
438054 AA776626 Hs62183 ESTs 39
436420 AA443966 Hs 31595 ESTs 39
445133 AW157646 Hs 153506 ESTs 39
432590 AI609273 Hs 110783 ESTs 39
453331 AI240665 Hs8895 ESTs 39
410227 AB009284 Hs61152 exostoses (mulbple)-lιke 2 38
424635 AA420687 Hs 115455 Homo sapiens cDNA FU14259 fis, clone PL 38
451489 NM 005503 Hs 26468 amyloid beta (A4) precursor protein bind 38
447247 AW369351 Hs 287955 Homo sapiens cDNA FU13090 fis, clone NT 38
448302 AI480208 Hs 182906 Homo sapiens mRNA for KIAA1872 protein, 38
415669 NM 005025 Hs78589 senne (or cysteine) proteinase inhibito 38
417355 D13168 Hs 82002 endothelin receptor type B 38
446727 AB011095 Hs 16032 KIAA0523 protein 38
424340 AA339036 Hs7033 ESTs 38
423346 AI267677 Hs 127416 synaptojanin 1 38
412788 AA120960 Hs 198416 ESTs 38
404593 38
416856 N27833 Hs269028 ESTs, Weakly similar to 138022 hypothed 38
429896 AA460367 Hs 224223 ESTs, Moderately similar to 138022 hypot 38
439619 AW975998 Hs 58595 ESTs, Weakly similar to 138022 hypotheti 38
-139634 W79377 Hs167 microtubule-associated protein 2 38
440322 AA879430 gb Oj91d08 s1 Soares.NFL_T_GBC.S1 Homo s 38
447761 AF061573 Hs 19492 protocadheππ 8 38
452453 AI902519 gb QV-BT009-101198-051 BT009 Homo sapien 38
439671 AW162840 Hs 6641 kmesin family member 5C 38
447937 AL109716 Hs 20034 Homo sapiens mRNA full length insert cDN 38
459278 AW294659 Hs 34054 Homo sapiens cDNA FLJ22488 fis, clone H 38
447028 AI973128 Hs 167257 brain link proteιn-1 38
449458 AI805078 Hs 208261 ESTs 38
445888 AF070564 Hs 13415 Homo sapiens clone 24571 mRNA sequence 38
407385 AA610150 Hs272072 ESTs, Weakly similar to I38022 hypotheti 38
428841 AI418430 Hs 104935 ESTs 38
430643 AW970065 Hs 287425 MEGF10 protein 38
422263 AA307639 Hs 129908 KIAA0591 protein 38
451625 R56793 Hs 106576 alanine glyoxylate aminotransferase 2 Ii 38
439236 BE160952 Hs 247117 ESTs, Moderately similar to ALUF_HUMAN ' 38
441928 AI370188 Hs 211454 ESTs 38
441797 AI936933 Hs 214635 ESTs 37
414922 D00723 Hs 77631 glycine cleavage system protein H (ammo 37
425588 F07396 Hs46751 ESTs 37
437007 AA741300 Hs 202599 ESTs, Weakly similar to I38022 hypothed 37
435793 AB037734 Hs 4993 KIAA1313 protein 37
443682 AI383061 Hs 47248 ESTs, Highly similar to similar to Cdc14 37
425741 AF052152 Hs 159412 Homo sapiens clone 24628 mRNA sequence 37
418211 BE244746 Hs 247474 hypothedcal protein FLJ21032 37
440080 AW051597 Hs 143707 ESTs 37
452898 AA814497 Hs78792 ESTs 37
435575 AF213457 Hs44234 tnggenng receptor expressed on myeloid 37
409234 AI879419 Hs 27206 ESTs 37
420489 AA815089 Hs 193513 ESTs 37
426890 AA393167 Hs 41294 ESTs 37
438849 W28948 Hs 10762 ESTs 37
441869 NM 003947 Hs 8004 hundπgtin associated protein interactm 37
448796 AA147829 Hs 301431 endothelial zinc finger protein induced 37
459318 NM 000038 gb Homo sapiens adenomatosis polyposis c 37
459518 AI937419 Hs 294069 Homo sapiens cDNA FLJ 13384 fis, clone PL 37
434444 AI765276 Hs 101257 hypothetical protein MGC3295 37
421183 AL135740 Hs 102447 TSC-22 like 37
410555 U92649 Hs 64311 a dis tegnn and etalloproteinase doma 37
421637 AF035290 Hs 106300 Homo sapiens clone 23556 mRNA sequence 37
418522 AA605038 Hs7149 Homo sapiens cDNA FLJ21950 fis, clone H 37
420807 AA280627 Hs 57846 ESTs 37
449961 AW265634 Hs 133100 ESTs 37
422634 NM.01601C Hs 118821 CGI-62 protein 37
421030 AW161357 Hs 101174 microtubule associated protein tau 37
427099 AB032953 Hs 173560 odd Oz/ten m homolog 2 (Drosophila, mous 37
452355 N54926 Hs 29202 G protein-coupled receptor 34 37
440483 AI200836 Hs 150386 ESTs 37
429597 NM_00381f Hs 2442 a dismtegnn and metalloproteinase doma 37
423756 AA828125 gb od71a09 s1 NCI_CGAP_Ov2 Homo sapiens 36
425187 AW014486 Hs 22509 ESTs 36
434859 BE255080 Hs 299315 collapsiπ response mediator proteιn-5, C 36
413199 M62843 Hs 75236 ELAV (embryonic lethal, abnormal vision, 36 445729 H21066 Hs 13223 Homo sapiens mRNA full length insert cDN 36
416120 H46739 gb yo14h02 s1 Soares adult brain N2b5HB5 36
429239 AA448419 Hs 45209 ESTs 36
419086 NM 000216 Hs 89591 Kallmann syndrome 1 sequence 36
446659 AI335361 Hs 226376 ESTs 36
426757 AW205640 Hs 158206 ESTs 36
418819 AA228776 Hs 191721 ESTs 36
458332 AI000341 Hs 220491 ESTs 36
408826 AF216077 Hs 48376 Homo sapiens clone HB-2 mRNA sequence 36
410343 AA084273 Hs 76561 ESTs, Weakly similar to S47072 finger pr 36
410507 AA355288 Hs 40834 transidonal epithelia response protein 36
422977 AA631498 gb np83h04s1 NCI_CGAP_Thy1 Homo sapiens 36
425305 AA363025 Hs 155572 Human clone 23801 mRNA sequence 36
428002 AA418703 gb zv98c03 s1 Soares.NhHMPu.S1 Homo sapi 36
428505 AL035461 Hs 2281 chromogranin B (secretograπm 1) 36
430530 AA480870 Hs 47660 ESTs 36
436425 AI913146 Hs 318725 CGI-72 protein 36
438078 AI016377 Hs 131693 ESTs 36
442927 AI024347 Hs 131519 ESTs 36
446242 N66336 Hs 7360 ESTs 36
448831 AL080123 Hs 22182 zinc finger protein 23 (KOX 16) 36
450474 AW872844 Hs 201919 ESTs 36
452198 AI097560 Hs 61210 ESTs, Weakly similar to I38022 hypotheti 36
455800 R22479 Hs 167073 Homo sapiens cDNA FU13047 fis, clone NT 36
436443 AW138211 Hs 128746 ESTs 36
426514 BE616633 Hs 170195 bone morphogenetic protein 7 (osteogenic 36
456038 AA203285 Hs 294141 ESTs, Weakly similar to alternatively sp 36
408902 AW014869 Hs 5510 ESTs 36
442950 AI500417 Hs 46764 ESTs 36
423905 AW579960 Hs 135150 lung type-l cell membrane associated gly 36
425478 AB007953 Hs 268840 ESTs 36
453884 AA355925 Hs 36232 KIAA0186 gene product 36
404721 36
408453 AI369838 Hs 45127 chondroitin sulfate proteoglycan 5 (neur 36
440553 AA889416 Hs 295362 Homo sapiens CDNA FLJ14459 fis clone HE 35
446372 AB020644 Hs 14945 long fatty acyl-CoA synthetase 2 gene 35
413999 N46124 Hs 34460 ESTs 35
421458 NM 003654 Hs 104576 carbohydrate (keratan sulfate Gal 6) sul 35
425017 AL119305 Hs 288405 ESTs 35
435958 H98180 Hs 117975 ESTs 35
415101 R45531 Hs 144534 ESTs 35
451320 AW118072 Hs 89981 diacylglycerol kinase, zeta (104kD) 35
430290 AI734110 Hs 136355 ESTs 35
416836 D54745 Hs 80247 cholecystokmm 35
414821 M63835 Hs 77424 Fc fragment of IgG, high affinity la, re 35
419412 AW161058 Hs 90297 synuclem, beta 35
437860 AA333063 Hs 279898 Homo sapiens cDNA FLJ23165 fis, clone L 35
452689 F33868 Hs 284176 transfemn 35
416661 AA634543 Hs 79440 IGF-II mRNA-b ding protein 3 35
427491 R43279 Hs 22574 ESTs, Weakly similar to I38022 hypothed 35
428037 N47474 Hs 89230 potassium intermediate/small conductance 35
444584 AH 68422 gb ok30e11 x1 Soares NSF.F8 9W_OT_PA_P_S 35
408296 AL117452 Hs 44155 DKFZP586G1517 protein 35
453775 NM 002916 Hs 35120 replication factor C (activator 1) 4 (37 35
412659 AW753865 Hs 74376 olfactomedin related ER localized protei 35
429077 AB028983 Hs 2352 adenylate cyclase 2 (brain) 35
436887 AW953157 Hs 193235 hypothetical protein DKFZp547D155 35
450784 AW246803 Hs 47289 ESTs 35
446827 AW451243 Hs 157069 ESTs 35
436434 N50465 Hs 92927 putative 47 kDa protein 35
412777 A1335773 Hs 270123 ESTs 35
436476 AA326108 Hs 33829 bHLH protein DEC2 35
408601 U47928 Hs 86122 protein A 34
429401 AW296102 Hs 99272 ESTs, Weakly similar to S32567 A4 protei 34
448425 AI500359 Hs 233401 ESTs 34
418727 AA227609 Hs 94834 ESTs 34
451729 AW160725 Hs 312469 ESTs 34
435910 AI084152 Hs 21782 ESTs, Weakly similar to ALU7.HUMAN ALU S 34
434577 R37316 Hs 179769 Homo sapiens cDNA FLJ22487 fis, clone H 34
414598 A1094221 Hs 135150 lung type I cell membrane associated gly 34
439627 BE621702 Hs 29076 hypothedcal protein FLJ21841 34
413293 AL047483 Hs 302498 GTP-binding protein homologous to Saccha 34
423992 AW898292 Hs 137206 Homo sapiens mRNA, cDNA DKFZp564H1663 (f 34
426249 F05422 Hs 168352 nucleopoπn like protein 1 34
426968 U07616 Hs 173034 amphiphysin (Sdff-Mann syndrome with br 34
430388 AA356923 Hs 240770 nuclear cap binding protein subunit 2, 2 34
435061 AI651474 Hs 163944 ESTs 34
452291 AF015592 Hs 28853 CDC7 (cell division cycle 7, S cerevisi 34
449714 AB033015 Hs 23941 KIAA1189 protein 34
443392 AI055821 Hs 293420 ESTs 34
410082 AA081594 Hs 158311 Musashi (Drosophila) homolog 1 34
445337 NM 013280 Hs 12523 fibronectin leucine πch transmembrane p 34
408493 BE206854 Hs 46039 phosphoglycerate mutase 2 (muscle) 34 432731 R31178 Hs 287820 fibronectin 1 34
448758 AB018311 Hs 21917 KIAA0768 protein 34
432613 AW081698 Hs 80712 KIAA0202 protein 34
434164 AW207019 Hs 148135 seπne/threonme kinase 33 34
425294 AF033827 Hs 155553 HNK-1 sulfotransferase 34
410108 AA081659 Hs 318775 OSBP-related protein 6 34
406815 AA833930 Hs 288036 tRNA isopentenylpyrophosphate transferas 34
402855 33
422170 AI791949 Hs 112432 and Mulleπaπ hormone 33
445034 AW293376 Hs 143659 ESTs 33
424378 W28020 Hs 167988 neural cell adhesion molecule 1 33
423611 AB011163 Hs 129908 KIAA0591 protein 33
435593 R88872 Hs 4964 DKFZP586J1624 protein 33
404819 33
436607 AW661783 Hs 211061 ESTs 33
427315 AA179949 Hs 175563 Homo sapiens mRNA, cDNA DKFZp564N0763 (f 33
452693 T79153 Hs 48589 zinc finger protein 228 33
454996 AW850180 gb IL3-CT0219-271099-022-C09 CT0219 Homo 33
406927 M26460 gb Homo sapiens (clone 104) rednoblasto 33
409045 AA635062 Hs 50094 Homo sapiens mRNA, cDNA DKFZp434O0515 (f 33
415238 R37780 Hs 21422 ESTs 33
417845 AL117461 Hs 82719 Homo sapiens mRNA, cDNA DKFZp586F1822 (f 33
421192 AA833718 Hs 204529 KIAA1806 protein 33
426695 AW118191 Hs 112729 ESTs 33
438885 AI886558 Hs 184987 ESTs 33
451762 AF222980 Hs 26985 disrupted in schizophrenia 1 33
452103 R42764 Hs 339654 ESTs, Weakly similar to I38022 hypotheti 33
453590 AF150278 Hs 33578 KIAA0820 protein 33
453616 NM.003462 Hs 33846 dyπeiπ, axoπemal, light intermediate pol 33
457285 AI038858 Hs 130522 Kv channel interacting protein 1 33
436045 AB037723 Hs 5028 DKFZP564O0423 protein 33
437470 AL390147 Hs 134742 hypothedcal protein DKFZp547D065 33
448520 AB002367 Hs 21355 doublecortin and CaM kinase-like 1 33
436480 AJ271643 Hs 87469 putative acid-sensing ion channel 33
432656 NM 000246 Hs 3076 MHC class II transactivator 33
443898 AW804296 Hs 9950 Sec61 gamma 33
423582 BE000831 Hs 23837 Homo sapiens cDNA FU11812 fis, clone HE 33
445953 AI612775 Hs 145710 ESTs 33
427940 AA417812 Hs 38775 ESTs 33
414683 S78296 Hs 76888 hypothedcal protein MGC12702 33
428484 AF104032 Hs 184601 solute earner family 7 (cationic ammo 33
420649 AI866964 Hs 124704 ESTs, Moderately similar to S65657 alpha 33
419498 AL036591 Hs 20887 hypothetical protein FLJ10392 33
457579 AB030816 Hs 36761 HRAS like suppressor 33
436556 AI364997 Hs 7572 ESTs 32
424369 R87622 Hs 26714 KIAA1831 protein 32
457065 AI476318 Hs 192480 ESTs 32
440210 AW674562 Hs 125296 ESTs 32
444513 AL120214 Hs 7117 glutamate receptor, lonotropic, AMPA 1 32
434353 AA630863 Hs 131375 ESTs, Moderately similar to ALUB_HUMAN ' 32
414430 AI346201 Hs 76118 ubiquitin carboxyl terminal esterase L1 32
439924 AI985897 Hs 125293 ESTs 32
411505 AF155659 Hs 70565 molybdenum cofactor synthesis 2 32
423175 W27595 Hs 18653 hypothetical protein FLJ 14627 32
415115 AA214228 Hs 127751 hypothedcal protein 32
407878 D87468 Hs 40888 activity-regulated cytoskeleton associat 32
410274 AA381807 Hs 61762 hypoxia inducible protein 2 32
437762 T78028 Hs 154679 synaptotagmin I 32
438944 AA302517 Hs 92732 KIAA1444 protein 32
450313 AI038989 Hs 332633 Bardet Biedl syndrome 2 32
409459 D86407 Hs 54481 low density lipoprotein receptor-related 32
410953 AW811766 Hs 334858 hypothetical protein MGC12250 32
418527 AA450386 Hs 7149 Homo sapiens cDNA FLJ21950 fis clone H 32
420081 AW510776 Hs 94958 tubulin tyrosine ligase like 1 32
429496 AA453800 Hs 192793 ESTs 32
430099 AW194988 Hs 20537 hypothedcal protein FLJ13942 32
434928 AW015595 Hs 4267 Homo sapiens clones 24714 and 24715 mRNA 32
435532 AW291488 Hs 117305 Homo sapiens, clone IMAGE 3682908, mRNA 32
438306 AW188266 Hs 163645 ESTs 32
439274 AF086092 Hs 48372 ESTs 32
440847 AA907511 Hs 130178 ESTs 32
447750 AI422234 Hs 143434 contacdn 1 32
455350 AW901809 gb QVO-NN1020-170400 195-h02 NN1020 Homo 32
430890 X54232 Hs 2699 glypican 1 32
420568 F09247 Hs 247735 protocadheπn alpha 10 32
410768 AF038185 Hs 66187 Homo sapiens clone 23700 mRNA sequence 32
427450 AB014526 Hs 178121 KIAA0626 gene product 32
430456 AA314998 Hs 241503 hypothedcal protein 32
430181 AF065314 Hs 234785 cyclic nucleotide gated channel alpha 3 32
418512 AW498974 Hs 89981 diacylglycerol kinase, zeta (104kD) 32
419912 AF249745 Hs 6066 Rho guanine nucleotide exchange factor ( 32
450689 AI369275 Hs 243010 Homo sapiens cDNA FLJ 14445 fis, clone HE 32
424899 AL119387 Hs 119062 ESTs 32 436277 R88520 Hs 120917 ESTs 32
451455 AI937227 Hs 8821 hepcidin andmicrobial peptide 32
445078 AI869975 Hs 4775 junctophiliπ 3 32
447746 AW015920 Hs 161359 ESTs 32
435458 F11872 Hs 4892 Homo sapiens clone 24841 mRNA sequence 32
427729 AB033100 Hs 300646 KIAA protein (similar to mouse paladin) 32
417417 F05745 Hs 89512 ATPase, Ca++ transporting, plasma membra 31
438810 AW897846 Hs 6421 hypothetical protein DKFZp761N09121 31
439570 T79925 Hs 269165 ESTs, Weakly similar to ALU1.HUMAN ALU S 31
432527 AW975028 Hs 102754 ESTs 31
416801 X98834 Hs 79971 sal (Drosophila) like 2 31
421988 AW450481 Hs 161333 ESTs 31
426509 M31166 Hs 2050 pentaxiπ-related gene, rapidly induced b 31
408786 AA773187 Hs 294027 ESTs 31
433494 AB029396 Hs 3353 beta-1,3-glucuronyltransferase 1 (glucur 31
412723 AA648459 Hs 335951 hypothetical protein AF301222 31
418329 AW247430 Hs 84152 cystathiomne-beta-synthase 31
439456 AI752409 Hs 109314 hypothetical protein FU20980 31
428832 AA578229 Hs 324239 ESTs, Moderately similar to ZN91_HUMAN Z 31
452780 BE171598 Hs 13522 ESTs, Weakly similar to I38022 hypothed 31
438192 AI859065 Hs 337620 Homo sapiens AFG3L1 isofoffn 1 mRNA, part 31
424939 AK000059 Hs 153881 Homo sapiens NY-REN 62 andgen mRNA, par 31
403053 R58624 Hs 2186 eukaryodc translation elongation factor 31
404299 31
407864 AF069291 Hs 0539 chromosome 8 open reading frame 1 31
410181 AI468210 Hs 261285 pleiotropic regulator 1 (PRL1, Arabidops 31
418852 BE537037 Hs 273294 hypothetical protein FLJ20069 31
449101 AA205847 Hs 23016 G protein-coupled receptor 31
453240 AI969564 Hs 166254 hypothetical protein DKFZp566H33 31
440486 BE243513 Hs7212 hypothetical protein PP1044 31
408096 BE250162 Hs 83765 dihydrofolate reductase 31
439864 AI720078 Hs 291997 ESTs, Weakly similar to A47582 B-cell gr 31
414706 AW340125 Hs 76989 KIAA0097 gene product 31
436315 BE390513 Hs 27935 hypothetical protein MGC4837 31
426855 AL117427 Hs 172778 Homo sapiens mRNA, cDNA DKFZp566P013 (fr 31
425683 AB037813 Hs 159200 hypothetical protein DKFZp762K222 31
410126 BE169274 Hs 169387 KIAA0036 gene product 31
435312 AJ243396 Hs 4865 voltage gated sodium channel beta-3 subu 31
425491 AA883316 Hs 255221 ESTs 31
456273 AF154846 Hs 1148 zinc finger protein 31
412140 AA219691 Hs 3625 RAB6 interacting, kinesin like (rabkines 31
445255 NM 014841 Hs 12477 synaptosomal-associated protein, 91 kDa 31
432154 AI701523 Hs 112577 ESTs 31
453128 AW026516 Hs 31791 acylphosphatase 2, muscle type 31
438458 AW975186 gb EST387294 MAGE resequences, MAGN Homo 31
448616 AF035621 Hs 21611 kinesin family member 3C 30
429281 AA830856 Hs 29808 Homo sapiens cDNA FLJ21122 fis, clone C 30
443906 AA348031 Hs 7913 ESTs 30
417318 AW953937 Hs 12891 ESTs 30
452619 AW298597 Hs 61884 Homo sapiens clone IMAGE 4298026, mRNA, 30
444153 AK001610 Hs 10414 hypothetical protein FU10748 30
408790 AW580227 Hs 47860 neurotrophic tyrosine kinase, receptor, 30
426327 W03242 Hs 44898 Homo sapiens clone TCCCTA00151 mRNA sequ 30
451468 AW503398 Hs 293663 ESTs, Moderately similar to I38022 hypot 30
422758 AF152329 Hs 284180 protocadhenn gamma subfamily C, 3 30
421633 AF121860 Hs 106260 sorting nexin 10 30
428361 NM 015905 Hs 183858 transcπpdonal intermediary factor 1 30
418932 L34059 Hs 89484 cadheππ 4, type 1, R-cadheπn (rednal) 30
416805 F13271 Hs 79981 Human clone 23560 mRNA sequence 30
419518 U79289 Hs 90798 Human clone 23695 mRNA sequence 30
422709 AA315331 Hs 153485 ESTs 30
423135 N67655 Hs 26411 ESTs 30
424901 Z11933 Hs 182505 POU domain, class 3, transcnpdon facto 30
426617 W58006 Hs 266258 endonuclease G-like 1 30
427386 AW836261 Hs 337717 ESTs 30
429859 NMJ-07050 Hs 225952 protein tyrosine phosphatase, receptor t 30
435071 D60683 Hs 35495 ESTs 30
435092 AL137310 Hs 4749 Homo sapiens mRNA cDNA DKFZp761E13121 ( 30
436211 AK001581 Hs 334828 hypothedcal protein FLJ10719, KIAA1794 30
436936 AL134451 Hs 197478 ESTs 30
445855 BE247129 Hs 145569 ESTs 30
452294 AI871925 Hs 117895 ESTs Moderately similar to A47582 B-cel 30
433980 AA137152 Hs 286049 phosphoseπne aminotransferase 30
430228 AW950939 Hs 6382 ESTs, Highly similar to T00391 hypothed 30
451026 AA013218 Hs 157492 cer-d4 (mouse) homolog 30
435232 NM 001262 Hs 4854 cyclin-depeπdent kinase inhibitor 2C (p1 30
439566 AF086387 gb Homo sapiens full length insert cDNA 30
425782 U66468 Hs 159525 cell growth regulatory with EF-hand doma 30
416586 D44643 Hs 14144 secreted modular calcium binding protein 30
416874 H98752 Hs 42568 ESTs 30
410386 W26187 Hs 3327 Homo sapiens cDNA FLJ22219 fis, clone H 30
411411 AA345241 Hs 55950 ESTs, Weakly similar to KIAA1330 protein 30
424066 Z99348 Hs 112461 ESTs, Weakly similar to I38022 hypotheti 30 404048 30
429163 AA884766 gb am20a10 s1 Soares.NFL_T_GBC.S1 Homo s 30
454117 BE410100 Hs 40368 adaptor-related protein complex 1, sigma 30
418196 AI745649 Hs 26549 KIAA1708 protein 30
434131 AI858275 Hs 143659 ESTs 30
441255 R06350 Hs 171635 ESTs 29
453900 AW003582 Hs 226414 ESTs, Weakly similar to ALU8_HUMAN ALU S 29
453905 NM 002314 Hs 36566 LIM domain kinase 1 29
416602 NM 006159 Hs 79389 nel (chιcken)-lιke 2 29
431173 AW971198 Hs 294068 ESTs 29
425599 AW366745 Hs 214140 ESTs, Weakly similar to ALU1 HUMAN ALU S 29
436401 AI087958 Hs 29088 ESTs 29
422960 AW890487 Hs 63984 cadheπn 13, H-cadheπn (heart) 29
451558 NM 001089 Hs 26630 ATP-bmding cassette, sub-family A (ABC1 29
412490 AW803564 Hs 288850 Homo sapiens cDNA FLJ22528 fis, clone H 29
433149 BE257672 Hs42949 hypothetical protein HES6 29
434811 AW971205 Hs 114280 ESTs 29
425897 AA935315 Hs 48965 Homo sapiens cDNA FLJ21693 fis, clone C 29
452092 BE245374 Hs 27842 hypothedcal protein FU11210 29
453496 AA442103 Hs33084 solute earner family 2 (facilitated glu 29
411124 AW196937 Hs 53929 ESTs, Weakly similar to ALUB_HUMAN ι«ι 29
419227 BE537383 Hs 89739 cholinergic receptor, nicodnic, beta po 29
427651 AW405731 Hs 18498 Homo sapiens cDNA FLJ12277 fis, clone MA 29
441707 R42637 Hs 21963 hypothetical protein DKFZp761B0514 29
435741 AI240668 Hs 113099 ESTs 29
437273 AL137451 Hs 120873 ESTs, Highly similar to T46266 hypotheti 29
422939 AW394055 Hs 98427 ESTs, Weakly similar to 138022 hypothed 29
439376 AA883521 Hs 222064 ESTs 29
439935 S75105 Hs 301676 glutamate receptor, lonotropic, kainate 29
437267 AW511443 Hs 258110 ESTs 29
453740 AL120295 Hs 311809 ESTs, Moderately similar to PC4259 fern 29
400250 29
400992 29
408814 N62499 Hs 176227 hypothetical protein FLJ 11155 29
411849 AW964970 Hs 18861 ESTs, Moderately similar to KIAA1276 pro 29
414853 U31116 Hs 77501 sarcoglycan, beta (43kD dystrophm-assoc 29
423751 AW235633 Hs 46525 ESTs 29
426910 AA470023 Hs 190089 ESTs, Moderately similar to ALU1_HUMAN A 29
450203 AF097994 Hs 301528 L-kynurenme/alpha a iπoadipate aminotra 29
459311 R40192 Hs 21527 Human DNA sequence from clone GS1-115M3 29
425304 AA463844 Hs 31339 fibroblast growth factor 11 29
428500 A1815395 Hs 184641 fatty acid desaturase 2 29
421641 AI638184 Hs 106334 Homo sapiens clone 23836 mRNA sequence 29
421141 AW117261 Hs 125914 ESTs 29
407870 AB032990 Hs 40719 hypothetical protein KIAA1164 29
456723 Z43902 Hs 4748 adenylate cyclase activadng polypeptide 29
436456 AW292677 Hs 248122 G protein-coupled receptor 24 29
421483 NM.003388 Hs 104717 hypothetical protein MGC11333 29
412190 R16180 Hs 274461 ESTs 29
446131 NM 000929 Hs290 phospholipase A2, group V 29
441668 AI611973 Hs 127525 ESTs 29
437387 AI198874 Hs 28847 AD026 protein 29
423420 AI571364 Hs 128382 Homo sapiens mRNA, cDNA DKFZp761H224 (f 29
427958 AA418000 Hs 98280 potassium intermediate/small conductance 29
429084 AJ001443 Hs 195614 splicing factor 3b, subunit 3, 130kD 29
447067 R42098 Hs 21964 ESTs 29
430887 N66801 Hs 260287 KIAA1841 protein 29
441824 AB007871 Hs 7977 KIAA0411 gene product 29
424126 AA335635 Hs96917 ESTs 29
408739 W01556 Hs 238797 ESTs, Moderately similar to I38022 hypot 29
447422 BE618703 Hs 98258 orthopedia (Drosphila) homolog 29
435615 Y15065 Hs 4975 potassium voltage-gated channel, KQT-lik 29
446997 AA383439 Hs 16758 Spιr-1 protein 29
433573 AF234887 Hs 57652 cadheπn, EGF LAG seven-pass G-type rece 29
408447 AK002089 Hs45080 Homo sapiens cDNA FLJ 11227 fis, clone PL 29
419586 AI088485 Hs 144759 ESTs, Weakly similar to I38022 hypotheti 28
417022 NM 014737 Hs 80905 Ras associadon (RalGDS/AF-6) domain fam 28
408432 AWT95262 gb xπ67b05 x1 NCI_CGAP_CML1 Homo sapiens 28
420320 AB002361 Hs 96633 KIAA0363 protein 28
425241 AA324624 Hs 155247 aldolase C, fructose-bisphosphate 28
428670 AA431682 Hs 134832 ESTs 28
424415 NM 001975 Hs 146580 enolase 2 (gamma, neuronal) 28
409185 AW961601 Hs 252406 hypothetical protein FLJ12296 similar to 28
411555 AF113537 Hs 70669 HMP19 protein 28
426847 S78723 Hs 298623 5-hydroxytryptamme (serotonin) receptor 28
458809 AW972512 Hs 20985 sιn3-assocιated polypeptide, 30kD 28
420071 AB028985 Hs 94806 ATP-binding cassette, sub-family A (ABC1 28
424572 M19650 Hs 150741 Z,3'-cycIιc nucleotide 3 phosphodieste 28
444670 H58373 Hs 332938 hypothetical protein MGC5370 28
411089 AA456454 Hs 183418 cell division cycle 2-lιke 1 (PITSLRE pr 28
416111 AA033813 Hs 79018 chromatin assembly factor 1, subunit A ( 28
440637 AW900115 Hs 7309 Homo sapiens clone 23741 mRNA sequence 28
408554 AA836381 Hs 315111 nuclear receptor co-repressor/HDAC3 comp 28 403056 R58624 Hs 2186 eukaryodc translation elongadon factor 28
423449 AI497900 Hs 33067 ESTs 28
424188 AW954552 Hs 142634 zinc finger protein 28
429006 AA443143 Hs 50929 hypothedcal protein FLJ 13842 28
434981 AW182577 Hs 293077 ESTs 28
437435 AA249439 Hs 27027 hypothedcal protein DKFZp762H1311 28
442748 AI016713 Hs 135787 ESTs 28
443312 N52025 Hs 46616 ESTs 28
450940 AI744943 Hs 143209 ESTs, Weakly similar to I38022 hypothed 28
452738 AL133800 Hs 7086 hypothedcal protein MGC12435 28
409182 AA064970 Hs 118145 ESTs 28
439793 AA018825 Hs 7934 Kruppel like factor 4 (gut) 28
432683 AW995441 Hs 10475 ESTs 28
434269 AK001991 Hs 3781 similar to muππe leucine rich repeat pr 28
429500 X78565 Hs 289114 hexabrachion (tenascin C, cytotxtin) 28
433290 R20077 Hs 302185 Homo sapiens clone 23618 mRNA sequence 28
434276 AF123659 Hs 93605 leucine zipper, putadve tumor suppresso 28
435977 AL138079 Hs 5012 brain specific membrane-anchored protein 28
430294 AI538226 Hs 32976 guanine nucleotide binding protein 4 28
425168 R96366 gb yq37d04 s1 Soares fetal liver spleen 28
428180 AI129767 Hs 182874 guanine nucleotide binding protein (G pr 28
409348 AI401535 Hs 146090 ESTs 28
409887 AL137534 Hs 56876 Homo sapiens mRNA cDNA DKFZp434H1419 (f 28
457211 AW972565 Hs 32399 ESTs, Weakly similar to S51797 vasodilat 28
430039 BE253012 Hs 153400 ESTs, Weakly similar to ALU1_HUMAN ALU S 28
417642 BE302665 Hs 105461 hypothetical prote FLJ20357 28
419169 AW851980 Hs 262346 ESTs, Weakly similar to S72482 hypotheti 28
434008 AA740878 Hs 112982 ESTs 28
446776 AW293417 Hs 156455 ESTs 28
408838 A1669535 Hs 40369 ESTs 28
422565 BE259035 Hs 118400 singed (Drosophila) like (sea urchin fas 28
447397 BE247676 Hs 18442 E-1 enzyme 28
412530 AA766268 Hs 266273 hypothetical protein FLJ13346 28
424330 AW073953 Hs 333396 Homo sapiens CDNA FU13596 fis clone PL 28
446377 AW014022 Hs 170953 ESTs 28
458924 BE242158 Hs 24427 DKFZP56601646 protein 28
447710 AI420523 Hs 328241 ESTs 28
404049 28
416913 AW934714 gb RC1-DT0001-031299-011-a11 DT0001 Homo 28
426400 M78361 Hs 169743 Homo sapiens clone 25121 neuronal olfact 28
413264 W26456 Hs 134757 hypothetical protein FLJ20033 28
458997 AW937420 Hs 69662 ESTs 27
422864 AA318323 gb EST20390 Retina II Homo sapiens cDNA 27
430526 AF181862 Hs 242407 G protein-coupled receptor, family C, gr 27
452023 AB032999 Hs 27566 KIAA1173 protein 27
432022 AL162042 Hs 272348 Homo sapiens mRNA cDNA DKFZp761L1212 (f 27
452438 BE514230 Hs 29595 JM4 protein 27
435408 H07897 Hs 4302 ESTs Weakly similar to T29299 hypothed 27
418791 AA935633 Hs 194628 ESTs 27
438821 AA826425 Hs 291829 ESTs 27
423464 NM 016240 Hs 128856 CSR1 protein 27
442091 AW770493 Hs 182874 guanine nucleotide binding protem (G pr 27
442242 AV647908 Hs 90424 Homo sapiens cDNA FLJ23285 fis, clone H 27
412436 AA665089 gb πu76d01 s1 NCI.CGAP.Alv1 Homo sapiens 27
432821 BE170702 Hs 279005 solute earner family 21 (organic anion 27
416404 AA180138 Hs 107924 ESTs 27
441364 AW450466 Hs 126830 ESTs, Weakly similar to YD38.YEAST HYPOT 27
450202 AW969756 Hs 34145 ESTs, Weakly similar to B49647 GTP-bindi 27
426304 AA374532 Hs 124673 Homo sapiens cDNA FLJ 11477 fis, clone HE 27
428722 U76456 Hs 190787 tissue inhibitor of metalloproteinase 4 27
449701 AW952323 Hs 129908 KIAA0591 protein 27
420372 AW960049 Hs 293660 Homo sapiens, clone IMAGE 3535476 mRNA, 27
410318 AA084050 Hs 269259 ESTs, Weakly similar to S23650 retroviru 27
414603 R58394 Hs 25119 ESTs Weakly similar to YEX0.YEAST HYPOT 27
416096 H18577 Hs 88974 cytochrome b-245 beta polypeptide (chro 27
420896 AW149342 Hs 24444 Homo sapiens cDNA FLJ22165 fis, clone H 27
424856 AA347746 Hs 9521 ESTs, Weakly similar to ZN43 HUMAN ZINC 27
436304 AA339622 Hs 108887 ESTs 27
441027 AI911412 Hs 126444 ESTs 27
452545 N31940 Hs 14434 ESTs, Weakly similar to I38022 hypothed 27
454201 AB023191 Hs 44131 KIAA0974 protein 27
448560 BE613183 Hs 23213 ESTs 27
426807 AA385315 Hs 156682 ESTs 27
425825 AI929508 Hs 159590 lymphocyte antigen 6 complex, locus H 27
440351 AF030933 Hs 7179 RAD1 (S pombe) homolog 27
425390 AI092634 Hs 156114 protein tyrosine phosphatase non recept 27
427624 AA406245 Hs 24895 ESTs 27
426413 AA377823 gb EST90805 Synovial sarcoma Homo sapien 27
422491 AA338548 Hs 117546 neuronatin 27
424560 AA158727 Hs 150555 protein predicted by clone 23733 27
432415 T16971 Hs 289014 ESTs, Weakly similar to A43932 mucin 2 p 27
414865 AA157155 Hs 274414 hypothetical protein FLJ 14457 27
415827 H17462 Hs 23079 ESTs 27 445568 H00918 Hs 268744 KIAA1796 protein 27
433315 R96754 Hs 239706 GRB2-assocιated binding protein 1 27
428862 NM 000346 Hs 2316 SRY (sex determining region Y) box 9 (ca 27
447959 AI452784 Hs 270270 ESTs, Weakly similar to 2109260A B cell 27
426420 BE383808 Hs 322430 NDRG family, member 4 27
436899 AA764852 Hs 291567 ESTs 27
444100 AA383343 Hs 22116 CDC14 (cell division cycle 14, S cerevi 27
426501 AW043782 Hs 293616 ESTs 27
449092 U91641 Hs 22985 alpha2,8-sιalyltransferase 27
427311 AB020672 Hs 175411 KIAA0865 protein 27
453313 BE005771 Hs 153746 hypothetical protein FU22490 27
404029 27
416289 W26333 Hs 337438 ESTs 27
439108 AW163034 ' Hs 6467 synaptogyπn 3 26
418746 AI955289 Hs 300759 πbosomal protein L36 26
412046 Y07847 Hs 73088 RAS related on chromsome 22 26
435040 AI932350 Hs 152825 ESTs 26
453083 U87223 Hs 31622 contacdπ associated protein 1 26
428167 AA770021 Hs 16332 ESTs 26
420028 AB014680 Hs 8786 carbohydrate (N-acetylglucosamine 6-0) s 26
443715 AI583187 Hs 9700 cyclin E1 26
421247 BE391727 Hs 102910 general transcnpdon factor HH, polype 26
424687 J05070 Hs 151738 matπx metalloproteinase 9 (gelatinase B 26
415056 AB004662 Hs 77867 adenosine A1 receptor 26
451697 AW449774 Hs 296380 POM (POM121 rat homolog) and ZP3 fusion 26
433701 AW445023 Hs 15155 ESTs 26
457358 AI479755 Hs 129010 ESTs 26
430347 NM.002039 Hs 239706 GRB2-assocιated binding protein 1 26
418027 AB037807 Hs 83293 hypothetical protein 26
440491 R35252 Hs 24944 ESTs, Weakly similar to 2109260A B cell 26
425171 AW732240 Hs 16365 ESTs 26
459335 AW298545 Hs 250726 EST 26
425402 AI215881 Hs 24970 ESTs, Weakly similar to B34323 GTP-bindi 26
453169 AB037815 Hs 32156 KIAA1394 protein 26
433647 AA603367 Hs 222294 ESTs 26
450414 AI907735 Hs 21446 KIAA1716 protein 26
446233 AI282028 Hs 25205 ESTs 26
415446 F08898 Hs 66075 ESTs 26
445873 AA250970 Hs 251946 poly(A) binding protein, cytoplasmic 1-1 26
413012 D83777 Hs 75137 KIAA0193 gene product 26
428671 BE297851 Hs 189482 zinc finger protein 179 26
427158 AA935603 Hs 166231 ESTs 26
408988 AL119844 Hs 49476 Homo sapiens clone TUA8 Cπ du-chat regi 26
459516 AI049662 Hs 246858 EST 26
402693 26
408039 AA131424 Hs 50340 ESTs 26
422896 AW961489 Hs 154116 ESTs 26
423130 AW897586 Hs 21213 ESTs 26
438796 W67821 Hs 109590 genethonin 1 26
439871 R88518 Hs 46736 hypothetical protein FLJ23476 26
440192 AA872282 Hs 190596 ESTs 26
419708 AK000753 Hs 92374 hypothetical protein 26
449436 AA860329 Hs 279307 hypothedcal protein DKFZp434l2117 26
436870 AW204219 Hs 155560 calnexin 26
448424 AW009892 Hs 31924 ESTs 26
401324 26
414136 AA812434 Hs 119023 SMC2 (structural maintenance of chromoso 26
433943 AA992805 Hs 44865 lymphoid enhancer-binding factor 1 26
428001 H97428 Hs 219907 ESTs, Moderately similar to Transforming 26
429139 F09092 Hs 66087 ESTs 26
423073 BE252922 Hs 123119 MAD (mothers against decapentaplegic, Dr 26
448966 AW372914 Hs 86149 phosphoinositol 3-phosphate binding prot 26
444001 AI095087 Hs 152299 ESTs, Moderately similar to S65657 alpha 26
412049 N53437 Hs 18268 adenylate kinase 5 26
441783 BE313412 Hs 7961 Homo sapiens clone 25012 mRNA sequence 26
425287 R88249 Hs 155524 peanut (Drosophila) like 2 26
432149 AW614326 Hs 157022 ESTs, Weakly similar to T34549 probable 26
452234 AW084176 Hs 223296 ESTs, Weakly similar to 138022 hypotheti 26
453478 AF083898 Hs 33021 neuro oncological ventral antigen 2 26
418962 AA714835 Hs 271863 ESTs 26
418858 AW961605 Hs 21145 hypothedcal protein RG083M052 26
443257 AI334040 Hs 11614 HSPC065 protein 26
428748 AW593206 Hs 98785 Ksp37 protein 26
444984 H15474 Hs 132898 fatty acid desaturase 1 26
433404 T32982 Hs 102720 ESTs 26
434779 AF153815 Hs 50151 potassium inwardly rectifying channel, s 26
420582 BE047878 Hs 99093 Homo sapiens chromosome 19, cosmid R2837 26
452856 AF034799 Hs 30881 protein tyrosine phosphatase, receptor t 26
436440 AI471862 Hs 196008 Homo sapiens cDNA FLJ11723 fis, clone HE 26
438527 AI969251 Hs 115325 RAB7, member RAS oncogene family-like 1 26
433216 AF217412 Hs 47320 neuroligm 3 26
435380 AA679001 Hs 192221 ESTs 26
428966 AF059214 Hs 194687 cholesterol 25-hydroxylase 26 439653 AW021103 Hs 6631 hypothetical protein FU20373 26
419304 AI271326 Hs 146101 ESTs, Weakly similar to T45070 protein k 26
422991 H10940 Hs 48965 Homo sapiens cDNA FLJ21693 fis, clone C 26
448548 R13209 Hs 21413 solute earner family 12, (potassium-chl 26
435370 AI964074 Hs 225838 ESTs 26
408875 NM 015434 Hs 48604 DKFZP434B168 protein 25
457005 AJ007421 Hs 172597 sal (Drosophila) like 3 25
430154 AW583058 Hs 234726 serine (or cysteine) proteinase iπhibito 25
438549 BE386801 Hs 21858 tnnucleodde repeat containing 3 25
427951 AI826125 Hs 43546 ESTs 25
411800 N39342 Hs 103042 microtubule associated protein 1B 25
457683 AI821877 Hs 140002 ESTs, Moderately similar to ALU7_HUMAN A 25
451422 AB002336 Hs 26395 erythrocyte membrane protein band 4 1-lι 25
430713 AA351647 Hs 2642 eukaryotic translation elongadon factor 25
428826 AL048842 Hs 194019 attracdn 25
428963 AW382682 Hs 258208 Homo sapiens, clone MGC 15606, mRNA, com 25
428141 D50402 Hs 182611 solute earner family 11 (proton-coupled 25
429550 AW293055 Hs 119357 ESTs 25
438662 AA223599 Hs 6351 cleavage and polyadeπyladon specific fa 25
435760 AF231922 Hs 213004 chromosome 21 open reading frame 62 25
427513 AI476318 Hs 192480 ESTs 25
430061 AB037817 Hs 230188 KIAA1396 protein 25
435923 BE301930 Hs 5010 Homo sapiens clone 24672 mRNA sequence 25
417123 BE326521 Hs 159450 ESTs 25
439699 AF086534 Hs 187561 ESTs, Moderately similar to ALU1.HUMAN A 25
412980 AI815750 Hs 20977 hypothetical protein MGC3129 similar to 25
427209 H06509 Hs 92423 KIAA1566 protein 25
424327 AA431707 Hs 31209 ESTs 25
436340 R42246 Hs 21606 ESTs 25
450650 T65617 Hs 101257 hypothedcal protein MGC3295 25
439444 AI277652 Hs 54578 ESTs, Weakly similar to I38022 hypotheti 25
400777 25
439478 AF049460 Hs 6574 deformed epidermal autoregulatory factor 25
450407 NM 000810 Hs 24969 gamma-aminobutync acid (GABA) A recepto 25
450385 AI631024 Hs 24948 synuclem, alpha interacdng protein (sy 25
432558 R97268 Hs 177269 ESTs 25
400860 25
410361 BE391804 Hs 62661 guanylate binding protein 1, terferon- 25
416063 BE047699 Hs 93454 ESTs 25
414998 NM 002543 Hs 77729 oxidised low density lipoprotein (lectin 25
452823 AB012124 Hs 30696 transcnpdon factor like 5 (basic helix 25
417791 AW965339 Hs 111471 ESTs 25
418079 R40058 Hs 6911 ESTs 25
408495 W68796 Hs 237731 ESTs 25
442104 L20971 Hs 188 phosphodiesterase 4B, cAMP-specific (dun 25
437370 AL359567 Hs 161962 Homo sapiens mRNA, cDNA DKFZp547D023 (fr 25
429803 W81489 Hs 223025 RAB31 , member RAS oncogene family 25
424959 NM 005781 Hs 153937 activated p21cdc42Hs kinase 25
427413 BE547647 Hs 177781 hypothedcal protein MGC5618 25
408955 BE315170 Hs 8087 NAG-5 protein 25
415261 T40928 Hs 8346 ESTs 25
415716 N59294 Hs 179662 nucleosome assembly protein 1-lιke 1 25
417873 BE266659 Hs 293659 Homo sapiens, Similar to RIKEN cDNA A430 25
418388 R72332 Hs 29258 Homo sapiens cDNA FLJ 11364 fis, clone HE 25
421002 AF116030 Hs 100932 transcription factor 17 25
423244 AL039379 Hs 209602 ESTs, Weakly similar to ubiquitous TPR 25
423553 AA405635 Hs 96854 ESTs, Weakly similar to DYLX_HUMAN CYTOP 25
427961 AW293165 Hs 143134 ESTs 25
428301 AW628666 Hs 98440 ESTs, Weakly similar to I38022 hypothed 25
428508 BE252383 Hs 184668 SBBI31 protein 25
428858 AA436760 gb zv67d11 r1 Soares_total_fetus_Nb2HF8_ 25
428943 AW086180 Hs 37636 ESTs, Weakly similar to KIAA1392 protein 25
432427 AL037630 Hs 6638 Homo sapiens cDNA FLJ 11602 fis, clone HE 25
435347 AW014873 Hs 116963 ESTs 25
437949 U78519 Hs41654 ESTs, Weakly similar to A46010 X-lmked 25
438208 AL041224 Hs 65379 ESTs 25
440286 U29589 Hs 7138 cholinergic receptor, muscaπnic 3 25
441523 AW514263 Hs 301771 ESTs, Weakly similar to ALUF.HUMAN »" 25
441805 AA285136 Hs 301914 neuronal specific transcnpdon factor D 25
442337 AI371029 Hs 129257 ESTs Weakly similar to TC17 HUMAN TRANS 25
442789 AW904361 Hs 131191 ESTs, Weakly similar to ALU7.HUMAN ALU S 25
445556 AI910241 Hs 12887 actin related protein 3-beta 25
449086 AI628357 Hs 208037 ESTs 25
459583 AI907673 gb IL-BT152 080399 004 BT152 Homo sapien 25
TABLE 8B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
408432 1058667 1 AW195262 R27868 AW811262
412225 1284108J AW902042 N77591 412436 129439 1 AA665089 AA135130 AA484059 AA102419 AW877765
416120 1571266_1 H46739 H51513 H19779
416871 1626761 1 H98716 N90792 24283
416913 163001J AW934714 BE161007 BE162500 AW749902 AW749864 BE162498 BE161005 AA190449 AW513465 BE161006 BE162499
422864 222336 1 AA318323 H 11145 R15289 AA451945 AA476690 AA436954 Z43802 F11753 T65491 D81821
422949 223184.1 AA319435 N56456 AA319377 AW961532 T48452 AA894424
422977 223410.1 AA631498 AI017191 AA491211 AA761823 AA714555 AA768099 AA808286 AI934069 AA570223 AA574389 AA582438 AI745346 AW964510 AA319642
AW853758 H56414
423756 231725 1 AA828125 AA834883 AA330555
425168 247552.1 R96366 AL133929 AA351636 H78818 AA477084 Z28957 H80194
425517 252729 1 AF121179 BE162736 AA358827
426413 266650.1 AA377823 AW954494 AI022688
428002 285602.1 AA418703AA418711 BE071915 BE071920 BE071912
428679 294049.1 AA431765 AA432015
428858 296453 1 AA436760 AW237453 BE327496 N47347 N56967
429007 298301.1 D80642 AA443145 AL119015 AW904500
429163 300543 1 AA884766 AW974271 AA592975 AA447312
433532 368950 1 AW975367 AA598607 AA742735
436190 41555 1 AK001059AA633055
437034 431713 1 AA742643 AA808575 AW976668
438458 457837.1 AW975186 AA807807 D29548
438993 467651 1 AA828995 AA834879 AI926361
439566 47387 1 AF086387 W77884W72711
440322 491966 1 AA879430 BE070262 BE070493 BE070272 BE070484 BE070397 BE070395 BE070201 BE070198 BE070404 BE070270 BE070400
444584 611496 1 A1168422 D80113T59074
447197 711623 1 36075 AI366546 R36167
448451 764066 1 AW015994 R39898 AW000978 AI598202 AI521706
450625 84032 1 AW970107 AA513951 AA010406
452453 918300 1 AI902519 AI902518 AI902516
454996 1248640 1 AW850180 AW850326
455350 1283853 1 AW901809 AW901787 AW901795 AW901792 AW901744 AW901753 AW901807 AW901798
TABLE 8C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham, et al " refers to the publication endtled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons
Pkey Ref Strand Nt position
400777 8131663 Plus 70745 71121
400780 8131663 Minus 118372-118619
400859 9757499 Minus 91888-92018,98131-98294,99474-99570
400860 9757499 Minus 151830-152104,152649-152744
400992 8096828 Plus 140390-140822
401324 9863791 Plus 234057-234174
402408 9796239 Minus 110326-110491
402604 9909420 Plus 20393-20767
402605 9909420 Minus 47680-47973
402693 8569863 Minus 82366-82515
402855 9662953 Minus 59763-59909
404029 7671252 Plus 108716-111112
404048 3688074 Minus 54421-56808
404049 3688074 Minus 75765-78155
404283 2276311 Minus 99460-99564
404299 5738652 Minus 3826-4025
404541 8318559 Plus 103456-103664
404584 9857511 Plus 138651-139153
404593 9944086 Minus 74922-75788
404721 9856648 Minus 173763-174294
404819 4678240 Plus 16223-16319,16427-16513,16736-16859,16941-17075,17170-17287,17389-17529,18261-18357,18443-18578
405238 7249119 Minus 5172851836
405771 7018349 Plus 91191-91254,91510-91589
405819 4007557 Plus 2830-2967
406311 9211559 Minus 137114-139033
TABLE 9A ABOUT 1202 GENES UP-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CENTRAL NERVOUS SYSTEM (CNS)
Table 9A lists about 1202 genes up-regulated in glioblastoma compared to normal adult central nervous system (CNS) These were selected from 59680 probesets on the
Affymetπx/Eos Hu03 GeneChip anay such that the ratio of "average" glioblastoma to "average" normal adult CNS dssues was greater than or equal to 20 The "average" glioblastoma level was set to the 75th percentile amongst various glioblastoma tumors The "average" normal adult CNS tissue level was set to the 95th percendle amongst vaπous non-malignant tissues In order to remove gene-specific background levels of non-specific hybridization, the 10th percendle value amongst various non-malignant dssues was subtracted from both the numerator and the denominator before the ratio was evaluated
Pkey Unique Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene title
R1 Ratio of 75th percendle tumor to 95th percentile normal adult nervous system tissue
Pkey ExAccn UnigenelD Unigene Title R1
452461 N78223 Hs 108106 transcnpdon factor 20 1
436895 AF037335 Hs 5338 carbonic anhydrase XII 152
453941 U39817 Hs 36820 Bloom syndrome 142 443247 BE614387 Hs 333893 c-Myc target JP01 124
428330 L22524 Hs 2256 matπx metalloproteinase 7 (matnlysin, 120
447342 AI199268 Hs 19322 Homo sapiens, Similar to RIKEN cDNA 2010 117
422163 AF027208 Hs 112360 prominm (mouse) like 1 114
439451 AF086270 Hs 278554 heterochromatm like protein 1 112
424800 AL035588 Hs 153203 MyoD family inhibitor 102
416111 AA033813 Hs 79018 chromatin assembly factor 1, subunit A ( 100
444190 AI878918 Hs 10526 cysteine and glycine-πch protein 2 99
412140 AA219691 Hs 73625 FΪAB6 interacting, kinesm-like (rabkines 99
449340 AW235786 Hs 195359 hypothetical protein MGC10954 98
409731 AA125985 Hs 56145 thymosiπ, beta, identified in πeuroblast 94
439978 BE139460 Hs 124673 Homo sapiens cDNA FLJ 11477 fis, clone HE 89
411411 AA345241 Hs 55950 ESTs, Weakly similar to KIAA1330 protein 89
456516 BE172704 Hs 222746 KIAA1610 protein 82
420092 AA814043 Hs 88045 ESTs 79
422631 BE218919 Hs 118793 hypothedcal protein FU10688 79
453392 U23752 Hs 32964 SRY (sex determining region Y) box 11 79
438527 AI969251 Hs 115325 RAB7, member RAS oncogene family-like 1 79
427581 NM 014788 Hs 179703 KIAA0129 gene product 78
418661 NM 001949 Hs 1189 E2F transcnpdon factor 3 78
440684 AI253123 Hs 127356 ESTs, Highly similar to S21424 nesdn [H 78
429643 AA455889 Hs 167279 FYVE-finger-containing Rab5 effector pro 77
409638 AW450420 Hs 21335 ESTs 75
444665 BE613126 Hs 47783 B aggressive lymphoma gene 75
456759 BE259150 Hs 127792 delta (Drosophila) like 3 75
412777 AI335773 Hs 270123 ESTs 74
436607 AW661783 Hs 211061 ESTs 73
432058 AW665996 Hs 130729 ESTs, Weakly similar to ALU1_HUMAN ALU S 73
417061 AI675944 Hs 188691 Homo sapiens cDNA FLJ12033 fis, clone HE 73
428976 AL037824 Hs 194695 ras homolog gene family, member I 72
433244 AB040943 Hs 271285 KIAA1510 protein 71
436726 AA324975 Hs 128993 ESTs, Weakly similar to T00079 hypotheti 71
408432 AW195262 gb xn67b05 x1 NC l_CGAP_CML1 Homo sapiens 71
434164 AW207019 Hs 148135 senne/threonine kinase 33 70
445873 AA250970 Hs 251946 poly(A) binding protein, cytoplasmic 1-1 70
439726 AW449893 Hs 293707 ESTs, Weakly similar to 138598 zinc fing 70
432656 NM 000246 Hs 3076 MHC class II transacdvator 68
431117 AF003522 Hs 250500 delta (Drosophila) like 1 68
453387 AI990741 Hs 252809 ESTs
418821 AA436002 Hs 183161 ESTs 66
437034 AA742643 gb ny91c01 s1 NCI_CGAP_GCB1 Homo sapiens 66
411252 AB018549 Hs 69328 MD-2 protein 65
424687 J05070 Hs 151738 matrix metalloproteinase 9 (geladnase B 64
452953 AI932884 Hs 271741 ESTs, Weakly similar to A4601O X-linked 63
433532 AW975367 gb EST387475 MAGE resequences, MAGN Homo 63
420311 AW445044 Hs 38207 Human DNA sequence from clone RP4-530I15 63
418097 R45137 Hs 21868 ESTs 62
407304 AA565832 gb π]32b03 s1 NCI_CGAP_AA1 Homo sapiens 62
435256 AF193766 Hs 13872 cytokine-like protein C17 61
449448 D60730 Hs 57471 ESTs 61
403790 60
425517 AF121179 gb AF121179 Homo sapiens liver (Chang L- 60
420674 NM 000055 Hs 1327 butyrylcholiπesterase 60
435542 AA687376 Hs 269533 ESTs 59
418216 AA662240 Hs 283099 AF15q14 protein 58
439086 AF085947 gb Homo sapiens full length insert cDNA 58
408037 AW271720 Hs 42233 hypothedcal protein FU 10300 57
412225 AW902042 gb QV0-NN1022-1704OO-193-C02 NN1022 Homo 57
436109 AA922153 Hs 132760 hypothetical protein MGC15729 57
435005 U80743 Hs 306094 tnnucleodde repeat containing 12 57
429149 AW193360 Hs 197962 ESTs, Weakly similar to I38022 hypothed 57
418113 AI272141 Hs 83484 SRY (sex determining region Y) box 4 56
405558 56
442432 BE093589 Hs 38178 hypothedcal protein FLJ23468 56
442547 AA306997 Hs 217484 ESTs, Weakly similar to ALU1_HUMAN ALU S 56
413063 AL035737 Hs 75184 chitmase 3-lιke 1 (cartilage glycoprote 55
420560 AW207748 HS 59115 ESTs 55
408096 BE250162 Hs 83765 dihydrofolate reductase 55
443539 AI076182 Hs 134074 ESTs, Moderately similar to ALU6.HUMAN A 54
426318 AA375125 Hs 147112 Homo sapiens cDNA FLJ22322 fis, clone H 54
429115 AA446728 Hs 289020 Homo sapiens cDNA FU14098 fis, clone MA 53
453900 AW003582 Hs 226414 ESTs, Weakly similar to ALU8 HUMAN ALU S 53
444168 AW379879 gb RC1-HT0256-081199-011-f01 HT0256 Homo 53
432789 D26361 Hs 3104 KIAA0042 gene product 53
437036 AI571514 Hs 133022 ESTs 52
421247 BE391727 Hs 102910 general transcπption factor HH, polype 52
441523 AW514263 Hs 301771 ESTs, Weakly similar to ALUF.HUMAN "" 52
451106 BE382701 Hs 25960 v myc avian myelocytomatosis viral relat 51
457211 AW972565 Hs 32399 ESTs, Weakly similar to S51797 vasodilat 51
454157 AW162906 Hs 312481 ESTs, Weakly similar to S66668 hydrogen 51
423343 AA324643 Hs 246106 ESTs 51
425292 NM.005824 Hs 155545 37 kDa leucine πch repeat (LRR) protein 51
406679 AA070786 gb zm66b07 r1 Stratagene neuroepithelium 51 442671 AI005668 Hs 134779 EST 51
433001 AF217513 Hs 279905 clone HQ0310 PRO0310p1 50
418819 AA228776 Hs 191721 ESTs 50
432946 U60899 Hs 279854 mannosidase, alpha class 2B member 1 49
420730 NM 002691 Hs 99890 polymerase (DNA directed) delta 1 cata 49
441217 AI922183 Hs 213246 ESTs 49
453385 AW296101 Hs 252806 ESTs 48
418203 X54942 Hs 83758 CDC28 protein kinase 2 47
450813 AI739625 Hs 203376 ESTs 47
444006 BE395085 Hs 10086 type I transmembrane protein Fn14 47
412530 AA766268 Hs 266273 hypothedcal protein FLJ13346 47
431070 AW408164 Hs 249184 transcπption factor 19 (SC1) 47
429786 AL080232 Hs 220696 Homo sapiens mRNA cDNA DKFZp586A061 (fr 47
405771 46
457065 AI476318 Hs 192480 ESTs 46
436190 AK001059 gb Homo sapiens cDNA FU10197 fis, clone 46
400859 46
435267 N23797 Hs 110114 ESTs 46
443454 AI057494 Hs 133421 ESTs 45
452811 AA937079 Hs 118983 hypothedcal protein FLJ12150 45
437267 AW511443 Hs 258110 ESTs 45
435020 AW505076 Hs 301855 DiGeorge syndrome cπtical region gene 8 45
454269 AI961060 Hs 129908 KIAA0591 protein 45
422106 D84239 Hs 111732 Fc fragment of IgG binding protein 45
422765 AW409701 Hs 1578 baculoviral IAP repeat-containing 5 (sur 45
456534 X91195 Hs 100623 phospholipase C, beta 3, neighbor pseudo 45
423756 AA828125 gb od71a09 s1 NCI_CGAP.Ov2 Homo sapiens 45
417308 H60720 Hs 81892 KIAA0101 gene product 45
422170 AI791949 Hs 112432 and-Mulleπan hormone 44
429500 X78565 Hs 289114 hexabrachion (tenascin C, cytotacdn) 44
406568 AF088886 Hs 11590 catheps F 44
426812 AF105365 Hs 172613 solute earner family 12 (potassium/chlo 44
402516 44
432865 AI753709 Hs 152484 ESTs, Weakly similar to 138022 hypothed 44
413625 AW451103 Hs 71371 ESTs 44
436098 R20597 Hs 9739 glycerol-3-phosphate dehydrogenase 1 (so 44
418333 W92113 gb zh48e01 r1 Soares_fetal_lιver_spleen_ 44
416933 BE561850 Hs 80506 small nuclear πbonucleoprotein polypept 44
438192 AI859065 Hs 337620 Homo sapiens AFG3L1 isoform 1 mRNA part 43
457374 AA493662 gb nh05d12 s1 NCLCGAP.Thyl Homo sapiens 43
433159 AB035898 Hs 150587 kinesiπ-like protein 2 43
444386 BE065183 gb RC1-BT0314-020200-012-C04 BT0314 Homo 43
453202 AW085781 Hs 26270 hypothetical protein FLJ 11588 43
441020 W79283 Hs 35962 ESTs 43
414733 BE514535 Hs 77171 minichromosome maintenance deficient (S 43
407902 AL117474 Hs 41181 Homo sapiens mRNA cDNA DKFZp727C191 (fr 43
405701 43
451659 BE379761 Hs 14248 ESTs 43
418845 AA852985 Hs 89232 chromobox homolog 5 (Drosophila HP1 alph 42
433323 AA805132 Hs 30701 ESTs 42
439811 AA135332 Hs 71608 ESTs 42
415406 T26510 gb AB282F8R Infant brain LLNL array of 42
436282 R91913 Hs 272104 ESTs Moderately similar to ALU1 HUMAN A 41
441269 AW015206 Hs 178784 ESTs 41
418727 AA227609 Hs 94834 ESTs 41
433006 BE242758 Hs 190223 ESTs, Moderately similar to T29285 hypot 41
436480 AJ271643 Hs 87469 putative acid sensing ion channel 4 1
430786 AA486144 Hs 31293 ESTs 41
445372 N36417 Hs 144928 ESTs 41
410555 U92649 Hs 64311 a dismtegnn and metalloproteinase doma 40
457465 AW301344 Hs 122908 DNA replication factor 40
422094 AF129535 Hs 272027 F-box only protein 5 40
442029 AW956698 Hs 14456 neural precursor cell expressed develop 40
459321 AW044477 Hs 299538 ESTs 40
421308 AA687322 Hs 192843 leucine zipper protein FKSG14 40
420567 AK000812 Hs 98874 similar to proline rich protein 48 40
447004 AW296968 Hs 157539 ESTs 40
448295 AI381911 Hs 334859 KIAA1814 protein 39
439699 AF086534 Hs 187561 ESTs, Moderately similar to ALU1.HUMAN A 39
440704 M69241 Hs 162 insulin like growth factor binding prate 39
453096 AW294631 Hs 11325 ESTs 39
457026 AA397620 Hs 48692 ESTs 39
404642 39
450375 AA009647 Hs 8850 a dismtegnn and metalloproteinase doma 39
430132 AA204686 Hs 234149 hypothetical protein FLJ20647 39
437718 AI927288 Hs 196779 ESTs 39
438490 AW593272 Hs 301299 ESTs 39
429919 AA460692 Hs 278945 hypothedcal protein FLJ23024 39
413604 R51767 gb yg73gl 1 r1 Soares infant brain 1 NIB H 39
425599 AW366745 Hs 214140 ESTs, Weakly similar to ALU1.HUMAN ALU S 39
448796 AA147829 Hs 301431 endothelial zinc finger protein induced 39
449300 AI656959 Hs 222165 ESTs 38
452203 X57522 Hs 158164 transporter 1, ATP-binding cassette, sub 38 425769 U72513 Hs 159486 Human RPL13-2 pseudogene mRNA, complete 38
404295 38
410361 BE391804 Hs 62661 guanylate binding protein 1, interferon 38
428728 NM 016625 Hs 191381 hypothetical protein 38
409142 AL136877 Hs 50758 SMC4 (structural maintenance of chromoso 38
430172 AA468591 Hs 161889 ESTs 38
447499 AW262580 Hs 147674 protooadherin beta 16 38
405884 38
437236 AW137817 Hs 244353 ESTs 37
418883 BE387036 Hs 1211 acid phosphatase 5, tartrate resistant 37
444143 AW747996 Hs 160999 ESTs, Moderately similar to A56194 throm 37
425529 NM.014656 Hs 158282 KIAA0040 gene product 37
425502 R98895 Hs 125823 ESTs 37
419741 NM.007019 Hs 93002 ubiquitin carrier protein E2-C 37
402424 37
429469 M64590 Hs 27 glycine dehydrogenase (decarboxyladng, 37
434072 H70854 Hs 283059 Homo sapiens PRO1082 mRNA, complete eds 37
414872 U82010 Hs 7513 COX10 (yeast) homolog, cytochrome c oxid 37
426071 AW138057 Hs 163835 ESTs 37
419078 M93119 Hs 89584 insulinoma-associated 1 37
428037 N47474 Hs 89230 potassium intermediate/small conductance 37
416547 H62914 Hs 268946 ESTs, Weakly similar to PC4259 ferntm 37
436899 AA764852 Hs 291567 ESTs 36
436722 AW975977 gb EST388086 MAGE resequences, MAGN Homo 36
440652 AI216751 Hs 143977 ESTs 36
428450 NM 014791 Hs 184339 KIAA0175 gene product 36
452103 R-42764 Hs 339654 ESTs, Weakly similar to I38022 hypothed 36
409048 H59990 Hs 37699 ESTs 36
439546 AF088056 gb Homo sapiens full length insert cDNA 36
443544 AI076315 Hs 16359 ESTs 36
418478 U38945 Hs 1174 cyclin-dependent kinase inhibitor 2A (me 36
435889 AI249107 Hs 269901 ESTs 36
420301 AA767526 Hs 22030 paired box gene 5 (B-cell lineage specif 36
438078 AI016377 Hs 131693 ESTs 36
408420 NM 006915 Hs 44766 retinitis pigmentosa 2 (X-linked recessi 36
416871 H98716 gb yx13d08 s1 Soares melanooyte 2NbHM Ho 35
424085 NMJ02914 Hs 139226 replication factor C (activator 1) 2 (40 35
446291 BE397753 Hs 14623 interferon, gamma-mducible protein 30 35
432281 AK001239 Hs 274263 hypothetical protein FLJ10377 35
436123 AA057484 Hs 35406 ESTs, Highly similar to unnamed protein 35
411256 AW834039 gb QV -TT0010 091199-053-e09 TT0010 Homo 35
419239 AA468183 Hs 184598 Homo sapiens cDNA FLJ23241 fis, clone C 35
435065 BE064391 gb RC4-BT0310-110300-015-b08 BT0310 Homo 35
435532 AW291488 Hs 117305 Homo sapiens, clone IMAGE 3682908, mRNA 35
447101 N72185 Hs 44189 ESTs 35
410530 M25809 Hs 64173 ATPase, H+ transporting lysosomal (vacu 35
422156 N34524 gb yy56d10 s1 Soares_multιple_sclerosιs_ 35
453616 NM 003462 Hs 33846 dynem, axoπemal, light intermediate pol 35
439743 AL389956 Hs 283858 Homo sapiens mRNA full length insert cDN 35
453884 AA355925 Hs 36232 KIAA0186 gene product 35
424954 NM 000546 Hs 1846 tumor protein p53 (Li Fraumem syndrome) 35
420721 AA927802 Hs 159471 ZAP3 protein 35
426764 AA732524 Hs 151464 ESTs, Weakly similar to ALUCJHUMAN "" 34
420649 AI866964 Hs 124704 ESTs, Moderately similar to S65657 alpha 34
448831 AL080123 Hs 22182 zinc finger protein 23 (KO 16) 34
444371 BE540274 Hs 239 forkhead box M1 34
402604 34
442407 AW469584 Hs 32353 mitogen-acdvated protein kinase kinase 34
414300 AI304870 Hs 188680 ESTs 34
444670 H58373 Hs 332938 hypothedcal protein MGC5370 34
414550 BE379808 gb 601159567T1 NIH MGC 53 Homo sapiens c 34
452211 AI985513 Hs 233420 ESTs 34
414416 AW409985 Hs 76084 hypothetical protein MGC2721 34
449961 AW265634 Hs 133100 ESTs 34
413257 BE075035 gb PM3-BT0584-260300 002-g05 BT0584 Homo 34
453857 AL080235 Hs 35861 DKFZP586E1621 protein 34
417404 NM 007350 Hs 82101 pleckstnn homology like domain, family 34
422846 BE513934 Hs 1583 neutrophil cytosolic factor 1 (47kD, chr 34
446189 H85224 Hs 214013 ESTs 34
437385 AA757055 Hs 164060 ESTs 34
453652 AW009640 Hs 28368 ESTs, Moderately similar to S65657 alpha 34
408298 A1745325 Hs 271923 Homo sapiens cDNA FLJ22785 fis, clone K 34
455778 BE088746 gb CM2-BT0693-210300-123-d09 BT0693 Homo 33
417546 H65569 Hs 18845 ESTs 33
412471 M63193 Hs 73946 endothelial cell growth factor 1 (platel 33
454631 AW811324 gb IL3-ST0141-131099-017-A02 ST0141 Homo 33
454294 AB000734 Hs 50640 JAK binding protein 33
457131 AC002310 Hs 301463 Human Chromosome 16 BAC clone CIT987SK-A 33
410102 AW248508 Hs 279727 Homo sapiens cDNA FLJ14035 fis, clone HE 33
449676 AW380579 Hs 209657 ESTs 33
436211 AK001581 Hs 334828 hypothetical protein FLJ10719, KIAA1794 33
453746 AL120611 gb DKFZp761H119_r1 761 (synonym hamy2) 33
452799 AI948829 Hs 213786 ESTs 33 435380 AA679001 Hs 192221 ESTs 33
426746 J03626 Hs 2057 undine monophosphate synthetase (orotat 33
453362 H14988 Hs 107375 ESTs 33
456473 AI202788 Hs 25682 Homo sapiens mRNA for KIAA1863 protein, 33
416426 AA180256 Hs 210473 Homo sapiens cDNA FU14872 fis, clone PL 33
445777 AI580371 Hs 145384 ESTs 33
423757 AL049337 Hs 132571 Homo sapiens mRNA, cDNA DKFZp564P016 (fr 33
431941 AK000106 Hs 272227 Homo sapiens cDNA FLJ20099 fis, clone CO 33
404299 33
404108 33
425189 H16622 gb ym26c07 r1 Soares infant brain 1 NIB H 33
449318 AW236021 Hs 78531 Homo sapiens, Similar to RIKEN cDNA 5730 33
450193 AI916071 Hs 15607 Homo sapiens Fanconi anemia complementat 32
427725 U66839 Hs 180533 mitogeπ-acdvated protein kinase kinase 32
424051 AL110203 Hs 138411 Homo sapiens mRNA, cDNA DKFZp586J1922 (f 32
418968 NM 000078 Hs 89538 cholesteryl ester transfer protein, plas 32
449248 M33782 Hs 23391 Homo sapiens, Similar to transcπption f 32
439416 W58294 Hs 56254 ESTs 32
401596 AA172106 Hs 110950 Rag C protein 32
408380 AF123050 Hs 44532 diubiquidn 32
450325 AI935962 Hs 26289 ESTs 32
428730 AA625947 Hs 25750 ESTs 32
457536 AA305233 Hs 278712 eukaryotic translation initiation factor 32
426836 N41720 Hs 172684 vesicle-associated membrane protein 8 (e 32
442710 AI015631 Hs 23210 ESTs 32
435232 NM 001262 Hs 4854 cyclin-dependeπt kinase inhibitor 2C (p1 32
430970 AI018210 Hs 144083 ESTs 32
416192 NM 005036 Hs 998 peroxisome proliferative xdvated recep 32
446676 H09380 Hs 300965 ESTs 32
451459 AI797515 Hs 270560 ESTs, Moderately similar to ALU7.HUMAN A 32
407603 AW955705 Hs 62604 Homo sapiens clone IMAGE 4299322, mRNA, 32
413840 AI301558 Hs 146381 RNA binding modf protein, X chromosome 32
448751 BE551203 Hs 201792 ESTs 32
432593 AW301003 Hs 51483 ESTs, Weakly similar to hypothetical pro 32
458786 AI457098 Hs 280848 ESTs 32
455909 BE156417 Hs 278798 ESTs 32
419311 AA689591 gb nv66a12 s1 NCI_CGAP_GCB1 Homo sapiens 32
439710 AF086543 gb Homo sapiens full length insert cDNA 32
434559 AF147315 gb Homo sapiens full length insert cDNA 31
455800 R22479 Hs 167073 Homo sapiens cDNA FLJ 13047 fis, clone NT 31
436703 AW880614 Hs 146381 RNA binding motif protein, X chromosome 3 1
414799 AI752416 Hs 77326 insulin-like growth factor binding prate 3 1
437860 AA333063 Hs 279898 Homo sapiens cDNA FU23165 fis, clone L 3 1
434182 W20309 Hs 118520 G-protem gamma-12 subunit 31
417900 BE250127 Hs 82906 CDC20 (cell division cycle 20, S cerevi 3 1
434769 AA648884 Hs 134278 Homo sapiens cDNA FLJ12676 fis, clone NT 3 1
414825 X06370 Hs 77432 epidermal growth factor receptor (avian 31
426413 AA377823 gb EST90805 Synovial sarcoma Homo sapien 31
447959 AI452784 Hs 270270 ESTs Weakly similar to 2109260A B cell 31
404589 3 1
421764 AI681535 Hs 148135 seππe/threoπine kinase 33 3 1
419986 AI345455 Hs 78915 GA binding protein transcription factor, 31
416941 BE000150 Hs 48778 niban protein 31
414761 AU077228 Hs 77256 enhancer of zeste (Drosophila) homolog 2 3 1
449611 AI970394 Hs 197075 ESTs 3 1
434746 AA648368 Hs 295368 ESTs 31
434274 AA628539 Hs 116252 ESTs, Moderately similar to ALU1_HUMAN A 31
427899 AA829286 Hs 332053 serum amyloid A1 31
417642 BE302665 Hs 105461 hypothetical protein FLJ20357 31
452472 AW957300 Hs 294142 ESTs, Weakly similar to C55663 odgodend 3 1
446131 NM 000929 Hs 290 phospholipase A2, group V 31
440052 AI633744 Hs 195648 ESTs, Weakly similar to I38022 hypotheti 31
426531 AA381071 gb EST94100 Activated T-cells XII Homo s 3 1
422158 L10343 Hs 112341 protease inhibitor 3, skin-deπved (SKAL 3 1
406267 31
447039 AV661798 Hs 282915 ESTs 31
404802 3 1
406927 M26460 gb Homo sapiens (clone 104) retinoblasto 3 1
419314 AW971924 Hs 87280 ESTs 30
435894 AI076667 Hs 188011 ESTs 30
432140 AK000404 Hs 272688 hypothedcal protein FLJ20397 30
443426 AF098158 Hs 9329 chromosome 20 open reading frame 1 30
425202 AW962282 Hs 152049 ESTs, Weakly similar to I38022 hypothed 30
407047 X65965 gb H sapiens SOD-2 gene for manganese su 30
418241 M26682 Hs 1149 LIM domain only 1 (rhombodn 1) 30
446599 Z97832 Hs 15476 differeπdally expressed in FDCP (mouse 30
412950 BE018581 Hs 245342 hypothetical protein FLJ14642 30
428670 AA431682 Hs 134832 ESTs 30
446975 BE246446 Hs 16695 ubiquitin activating enzyme E1-lιke 30
437756 AA767537 Hs 197096 ESTs 30
416084 L16991 Hs 79006 deoxythymidylate kinase (thymidylate km 30
402374 AL135225 Hs 301865 dopachrome tautomerase (dopxhrome delta 30
443885 H91806 Hs 15284 ESTs 30 434008 AA740878 Hs 112982 ESTs 30
452568 AA805634 Hs 300870 Homo sapiens mRNA, cDNA DKFZp547M072 (fr 30
414239 AI288330 Hs 182330 ESTs 30
421013 M62397 Hs 1345 mutated in colorectal cancers 30
424635 AA420687 Hs 115455 Homo sapiens cDNA FLJ14259 fis, clone PL 30
410276 AI554545 Hs 68301 ESTs 30
433865 N29862 Hs 44104 ESTs 30
406028 30
401626 30
415949 H10562 Hs 21691 ESTs 30
418583 AA604379 Hs 86211 hypothetical protein 30
417933 X02308 Hs 82962 thymidylate synthetase 30
434577 R37316 Hs 179769 Homo sapiens cDNA FLJ22487fis clone H 30
430437 AI768801 Hs 169943 Homo sapiens cDNA FU13569 fis, clone PL 30
427940 AA417812 Hs 38775 ESTs 29
456060 C14904 Hs 45184 Homo sapiens cDNA FU12284 fis, clone MA 29
421988 AW450481 Hs 161333 ESTs 29
448775 AB025237 Hs 388 nudix (nucleoside diphosphate linked moi 29
438598 AI805943 Hs 326067 hypothedcal protein MGC5178 29
429612 AF062649 Hs 252587 pituitary tumor-transforming 1 29
451189 AA016019 Hs 40905 ESTs 29
401558 29
426207 BE390657 Hs 30026 HSPC182 protein 29
404721 29
401384 29
417288 AI984792 Hs 108812 hypothetical protein FLJ22004 29
427648 AI376722 Hs 180062 proteasome (prosome, macropain) subunit, 29
435928 H64345 Hs 183961 ESTs 29
431740 N75450 Hs 183412 ESTs, Moderately similar to AF116721 67 29
428242 H55709 Hs 2250 leukemia inhibitory fxtor (cholinergic 29
439972 AI348100 Hs 124662 ESTs 29
433112 AA973801 Hs 144553 ESTs, Weakly similar to unnamed protein 29
423751 AW235633 Hs 46525 ESTs 29
406748 AW339106 Hs 217493 annexin A2 29
422154 T79045 Hs 126927 ESTs 29
405588 29
440911 AA909536 Hs 143562 ESTs 29
412420 AL035668 Hs 73853 bone morphogenetic protein 2 29
445043 AW014413 Hs 196066 ESTs 29
410114 AW590540 Hs 271280 ESTs 29
419217 AA504571 gb aa60e12 r1 NCI CGAP GCB1 Homo sapiens 29
415849 R20529 Hs 6806 ESTs 29
448140 AF146761 Hs 20450 BCM like membrane protein precursor 29
453331 AI240665 Hs 8895 ESTs 29
432065 AA401039 Hs 2903 protein phosphatase 4 (formerly X), cata 29
438380 T06430 Hs 6194 chondroitin sulfate proteoglycan BEHAB/b 29
454377 AA076811 gb 7B03C12 Chromosome 7 Fetal Brain cDNA 29
421491 H99999 Hs 42736 ESTs 29
452291 AF015592 Hs 28853 CDC7 (cell division cycle 7, S cerevisi 28
415446 F08898 Hs 66075 ESTs 28
439518 W76326 gb zd60d04 r1 Soares_fetal_heart_NbHH19W 28
427221 L15409 Hs 174007 von Hippel-ϋndau syndrome 28
422493 AW474183 Hs 250173 hypothetical protein FLJ13158 28
419451 AI907117 Hs 90535 syntaxin binding protein 2 28
448789 BE539108 Hs 22051 hypothetical protein MGC15548 28
424126 AA335635 Hs 96917 ESTs 28
458695 AV660159 Hs 282284 ESTs, Weakly similar to I38022 hypotheti 28
418973 AA233056 Hs 191518 ESTs 28
440471 AA886146 Hs 307944 ESTs 28
421016 AA504583 Hs 101047 transcnpdon factor 3 (E2A immunoglobul 28
433647 AA603367 Hs 222294 ESTs 28
415817 U88967 Hs 78867 protein tyrosine phosphatase, receptor-t 28
421723 AA620400 Hs 300717 sodium channel, voltage gated, type III, 28
434964 AI638850 Hs 130746 ESTs 28
432022 AL162042 Hs 272348 Homo sapiens mRNA, cDNA DKFZp761 1212 (f 28
400517 AF242388 Hs 149585 lengsm 28
433023 AW864793 Hs 87409 thrombospondin 1 28
448734 BE614070 Hs 326416 Homo sapiens mRNA, cDNA DKFZp564H1916 (f 28
406736 AI254733 Hs 182426 πbosomal protein S2 28
409207 AW373564 Hs 194637 BANP homolog, SMAR1 homolog 28
440196 N72847 Hs 125221 ESTs 28
403961 28
425193 AW965689 Hs 22509 ESTs 28
425268 AI807883 Hs 180059 Homo sapiens cDNA FLJ20653 fis, clone KA 28
440483 AI200836 Hs 150386 ESTs 28
412391 AW947710 gb RCO-MT0004-130300-011-e07 MT0004 Homo 2.8
448769 N66037 Hs 38173 ESTs 28
411632 AW854829 gb QV2-CT0261-201099 011-f01 CT0261 Homo 28
438221 AI798853 Hs 122224 ESTs, Weakly similar to ALU5.HUMAN ALU S 28
457578 AA578027 gb nl20h01 s1 NCI.CGAP.HSC1 Homo sapiens 28
455510 AA422029 Hs 143640 ESTs, Weakly similar to hyperpolaπzatio 28
447769 AW873704 Hs 320831 Homo sapiens cDNA FLJ14597 fis, clone NT 28
427701 AA411101 Hs 243886 nuclear autoantigenic sperm protein (his 28 433800 AI034361 Hs 135150 lung type-l cell membrane-associated gly 28
439662 H97552 Hs 269060 ESTs 28
425694 U51333 Hs 159237 hexok ase 3 (white cell) 28
414747 U30872 Hs 77204 centromere protein F (350/400kD, mitosin 28
414598 AI094221 Hs 135150 lung type 1 cell membrane-associated gly 28
447752 M73700 Hs 105938 lactotransfemπ 28
408761 AA057264 Hs 238936 ESTs, Weakly similar to (deflme not ava 28
453350 AI917771 Hs 61790 hypothetical protein FLJ23338 27
456629 AW891965 Hs 279789 histone deacetylase 3 27
439538 AA837323 Hs 164047 ESTs 27
458814 A1498957 Hs 170861 ESTs, Weakly similar to Z195_HUMAN ZINC 27
456029 BE255990 Hs 218329 hypothetical protein 27
451129 BE072881 gb RC2-BT0548-200300-012-e09 BT0548 Homo 27
456412 AW749617 Hs 280776 tankyrase, TRF1-mteracdπg ankyπn rela 27
453536 AA137000 Hs 62578 ESTs 27
438378 AW970529 Hs 86434 hypothetical protein FU21816 27
425745 U44060 Hs 14427 Homo sapiens cDNA FLJ21800 fis, clone H 27
446322 N23033 Hs 155814 ESTs 27
451592 AI805416 Hs 213897 ESTs 2.7
429466 M85835 Hs 12827 ESTs 27
429747 M87507 Hs 2490 caspase 1, apoptosis-related cysteine pr 27
455514 AW983871 gb RC1-HN0003-220300 021-h07 HN0003 Homo 27
414732 AW410976 Hs 77152 minichromosome maintenance deficient (S 27
444207 AI565004 Hs 79572 catheps D (lysosomal aspartyl protease 27
427421 AA402414 Hs 3059 coatomer protein complex, subunit beta 27
449655 AI021987 Hs 59970 ESTs 27
422648 D86983 Hs 118893 Melanoma associated gene 27
428494 AA233439 Hs 184634 hypothetical protem FLJ20005 27
406895 X60648 Hs 172550 polypyπmidine tract binding protein (he 27
453255 AA278167 Hs 19215 Homo sapiens, clone IMAGE 3605822, mRNA 27
427348 NM 014137 Hs 177258 PRO0650 protein 27
435370 AI964074 Hs 225838 ESTs 27
407862 BE548267 Hs 50724 Homo sapiens cDNA FLJ10934 fis, clone OV 27
411874 AA096106 Hs 20403 ESTs 27
421192 AA833718 Hs 204529 KIAA1806 protein 27
435899 W89093 Hs 189914 ESTs 27
414603 R58394 Hs 25119 ESTs, Weakly similar to YEX0 YEAST HYPOT 27
453462 AL037291 Hs 236605 ESTs, Moderately similar to ALU4 HUMAN A 27
436554 AI985810 Hs 301173 ESTs 27
427528 AU077143 Hs 179565 minichromosome maintenance deficient (S 27
403881 27
431779 AW971178 Hs 268571 apolipoprotein C-l 27
404984 27
448275 BE514434 Hs 20830 kinesm-like 2 27
446839 BE091926 Hs 16244 mitotic spindle coiled-coil related prot 27
411927 BE274009 Hs 772 glycogen synthase 1 (muscle) 27
404756 27
447072 D61594 Hs 17279 tyrosylprotem sulfotransferase 1 27
422176 H80977 gb yu89a11 s1 Soares fetal liver spleen 27
439627 BE621702 Hs 29076 hypothetical protein FLJ21841 27
436532 AA721522 gb nv54h12 r1 NCI_CGAP_Ew1 Homo sapiens 27
412833 AW960547 Hs 298262 nbosomal protein S19 27
457245 AI745498 Hs 204579 ESTs 27
446861 AI696519 Hs 14427 Homo sapiens cDNA FLJ21800 fis, clone H 27
453263 R91778 Hs 99369 ESTs 27
459385 BE380047 gb 601159362F2 NIH MGC 53 Homo sapiens c 27
438764 AA824524 Hs 336452 ESTs 27
429285 AI971081 Hs 20432 ESTs, Weakly similar to I38022 hypotheti 27
424853 BE549737 Hs 132967 Human EST clone 122887 manner transposo 27
430037 BE409649 Hs 227789 mitogen-acdvated protein kinase-activat 27
449892 N73608 Hs 50309 ESTs 27
454201 AB023191 Hs 44131 KIAA0974 protein 27
452279 AA286844 Hs 61260 hypothetical protein FLJ13164 27
427954 J03060 Hs 247551 metaxin 1 27
400371 U80740 27
452449 AW068658 Hs 20943 ESTs 27
431114 AA492400 Hs 291015 ESTs 27
417088 M54915 Hs 81170 pιm-1 oncogene 27
447674 BE270640 Hs 19192 cyclin-dependent kinase 2 27
403680 27
454679 AW813110 gb CM4-ST0189 051099 021-KB ST0189Homo 27
411968 AI207410 Hs 69280 Homo sapiens, clone IMAGE 3636299, mRNA 26
422240 R60594 Hs 29002 KIAA1706 protein 26
424368 AB037766 Hs 146085 KIAA1345 protein 26
405808 26
419700 AF084935 Hs 92357 galactokinase 1 26
435972 W95088 Hs 114198 ESTs 26
453568 S70782 Hs 557 adrenergic, alpha 1D , receptor 26
443725 AW245680 Hs 9701 growth arrest and DNA-damage inducible, 26
444156 AW500059 Hs 86437 ESTs, Highly similar to AF219140 1 gastr 26
428209 AA424197 Hs 98947 ESTs, Weakly similar to S33496 trypsin [ 26
437640 AA764893 Hs 272155 ESTs, Weakly similar to I38022 hypothed 26
453948 AI970797 Hs 64859 ESTs 26 415402 AA164687 Hs 177576 mannosyl (alpha-1,3-) glycoprotein beta- 26
425397 J04088 Hs 156346 topoiso erase (DNA) II alpha (170kD) 26
418228 AA962181 Hs 111219 ESTs, Moderately similar to ALU1_HUMAN A 26
401324 26
425234 AW152225 Hs 165909 ESTs, Weakly similar to I38022 hypotheti 26
443210 AI692649 Hs 9451 hypothetical protein MGC13168 26
457244 AA581385 Hs 162473 ESTs, Weakly similar to I38022 hypotheti 26
417144 AA382104 Hs 81337 lecdn, galactoside-bmding, soluble, 9 26
433933 AI754389 Hs 133494 Homo sapiens clone TCCCIA00164 mRNA sequ 26
437437 AA226869 Hs 16520 hypothetical protein DKFZp762L0311 26
434206 AW136973 Hs 288516 ESTs, Weakly similar to SΘ9890 mitogen i 26
400992 26
455530 AW984744 gb RC1-HN0015-040400 011-d03 HN0015 Homo 26
436139 AA765786 Hs 120936 ESTs 26
448330 AL036449 Hs 207163 ESTs 26
412942 AL120344 Hs 75074 mitogen-acdvated protein kinase-acdvat 26
432753 NM 014075 Hs 336938 Homo sapiens PRO0593 mRNA, complete eds 26
433430 AI863735 Hs 186755 ESTs 26
436693 AW973223 Hs 303197 B-cell CLL/lymphoma 7C 26
429482 AF076974 Hs 203952 transformation/transcription doma -asso 26
432715 AA247152 Hs 200483 ESTs, Weakly similar to KIAA1074 protein 26
414217 AI309298 Hs 279898 Homo sapiens cDNA FLJ23165 fis, clone L 26
434165 AA971328 Hs 95361 myosin VIIA (Usher syndrome 1 B (autosoma 26
414835 AA156720 Hs 185342 ESTs 26
424489 T48851 Hs 149250 D-siglec precursor, 26
436496 AA281959 Hs 5210 glia maturadon factor, gamma 26
403797 26
434573 AW372340 Hs 159717 ESTs 26
418841 NM 002332 Hs 89137 low density lipoprotein-related protein 26
415785 R82419 Hs 23603 ESTs, Moderately similar to ALU8 HUMAN A 26
450608 AA010365 Hs 193229 ESTs 26
425304 AA463844 Hs 31339 fibroblast growth factor 11 26
432268 BE311856 Hs 274230 3'-phosphoadenosιne 5'-phosphosulfate sy 26
410507 AA355288 Hs 40834 transitional epithelia response protein 26
427343 AI880044 Hs 176977 protein kinase C binding protein 2 26
420917 AW135716 Hs 117330 ESTs 26
414399 L47345 Hs 155202 transcription elongation factor B (Sill) 26
446089 AI860021 Hs 270651 ESTs, Moderately similar to A47582 B-cel 26
440829 AF136407 Hs 7446 chromosome 6 open reading frame 5 26
408475 AA315514 Hs 47986 hypothedcal protein MGC10940 26
450946 AA374569 Hs 127698 ESTs, Moderately similar to 2109260A B c 26
421462 AF016495 Hs 104624 aquapoπn 9 26
434846 AW295389 Hs 119768 ESTs 26
422887 AI751848 Hs 49215 ESTs 26
417435 NM 005181 Hs 82129 carbonic anhydrase III, muscle specific 26
437389 AL359587 Hs 271586 hypothetical protein DKFZp762M115 25
408981 AW500797 Hs 49427 Gem interacting protein 25
432180 Y18418 Hs 272822 RuvB (E coli homolog) like 1 25
418079 R40058 Hs 6911 ESTs 25
437820 AA769062 Hs 323836 ESTs Weakly similar to alternatively sp 25
439685 AW956781 Hs 293937 ESTs, Weakly similar to FXD2.HUMAN FORKH 25
425681 AB018297 Hs 159183 KIAA0754 protein 25
435177 AI018174 Hs 42936 ESTs 25
437323 AA371145 Hs 226627 leptin receptor 25
422114 AW194851 Hs 111801 arsenate resistance protein ARS2 25
448478 AI523218 Hs 203456 ESTs 25
426623 AA382826 Hs 132793 ESTs 25
448764 AI568607 Hs 182112 ESTs 25
458385 AI051489 Hs 246214 ESTs 25
403726 N28939 Hs 13434 Homo sapiens clone 24418 mRNA sequence 25
444888 AI651039 Hs 148559 ESTs 25
456179 H75490 Hs 271930 ESTs 25
424840 D79987 Hs 153479 extra spindle poles, S cerevisiae, homo 25
406273 NM 000919 Hs 83920 peptidylglycme alpha amidating monooxyg 25
418054 NM 002318 Hs 83354 iysyl oxidase like 2 25
445936 BE543594 Hs 61478 hypothetical protein FLJ22329 25
454967 AW848276 gb IL3-CT0214-150200-074-E06 CT0214 Homo 25
442303 AA989289 Hs 129169 ESTs 25
456583 AF179897 Hs 104105 Meis (mouse) homolog 2 25
434263 N34895 Hs 44648 ESTs 25
416892 L24498 Hs 80409 growth aπest and DNA damage inducible, 25
424528 AW073971 Hs 238954 ESTs Weakly similar to KIAA1204 protein 25
406038 Y14443 Hs 88219 zinc finger protein 200 25
413495 Y12395 Hs 315177 interferon related developmental regulat 25
423098 AA321980 Hs 204682 ESTs 25
410817 AI262789 Hs 93659 protein disulfide isomerase related prot 25
439841 AF038961 Hs 6710 mannose-P-dolichol utilization defect 1 25
453828 AW970960 Hs 293821 ESTs 25
445034 AW293376 Hs 143659 ESTs 25
449620 BE407797 Hs 23794 checkpoint with forkhead and πng finger 25
406876 AI382286 Hs 180842 πbosomal protein L13 25
412370 AW946614 gb RC2-ET0021 280400-011-c05 ET0021 Homo 25
423642 AW452650 Hs 157148 hypothetical protein MGC13204 25 430357 AW976789 Hs 165607 ESTs 25
414853 U31116 Hs 77501 sarcoglycan, beta (43kD dystroph assoc 25
416097 BE387371 Hs 118964 hypothetical protein FLJ20085 25
428619 AK002140 Hs 187378 hypothetical protein FLJ 11278 25
413976 BE295452 Hs 75655 procollagen-proline, 2 oxoglutarate 4-dι 25
445223 AW291553 Hs 254983 ESTs 25
423926 X03833 Hs 1722 interieukin 1, alpha 25
410165 BE560228 Hs 71869 apoptosis-associated speck-like protein 25
406474 25
433908 AW298141 Hs 157975 ESTs 25
439755 AW748482 Hs 77873 B7 homolog 3 25
437528 N59646 Hs 169745 crumbs (Drosophila) homolog 1 25
420734 AW972872 Hs 293736 ESTs 25
415346 Z43108 gb HSC13E071 normalized infant brain cDN 25
419337 AW291112 Hs 209978 ESTs 25
444606 R09478 Hs 18041 ESTs 25
430061 AB037817 Hs 230188 KIAA1396 protein 25
413407 AI356293 Hs 75339 inositol polyphosphate phosphatase-like 25
411965 BE467339 Hs 280115 ESTs 25
409278 AA346683 Hs 52763 anaphase-promoting complex subunit 7 25
403142 25
401714 25
425081 X74794 Hs 154443 minichromosome maintenance deficient (S 25
416505 H66470 Hs 16004 ESTs 25
431518 AA743462 Hs 165337 ESTs 25
448623 BE613468 Hs 107515 ESTs, Weakly similar to T00329 hypothed 25
428301 AW628666 Hs 98440 ESTs, Weakly similar to I38022 hypothed 25
404366 25
449733 R74546 Hs 29438 Homo sapiens cDNA FLJ12094 fis, clone HE 25
459583 AI907673 gb IL-BT152-080399-004 BT152 Homo sapien 25
402856 AW939659 gb RCO-DT0076-110100-031-C09 DT0076 Homo 25
420751 J03019 Hs 99913 adrenergic, beta-1-, receptor 24
436805 AA731533 Hs 270751 ESTs 24
420285 AA258124 Hs 293878 ESTs, Moderately similar to ZN91_HUMAN Z 24
453496 AA442103 Hs 33084 solute carrier family 2 (facilitated glu 24
453853 AL040600 Hs 188083 ESTs 24
407909 AW103986 gb xd63e06 x1 NCI CGAP Ov23 Homo sapiens 24
454630 BE142075 gb CM3-HT0137-170999 012-f02 HT0137 Homo 24
451026 AA013218 Hs 157492 cer-d4 (mouse) homolog 24
420779 L12398 Hs 99922 dopamine receptor D4 24
438322 AA804170 Hs 221349 ESTs 24
455908 BE156306 gb QV0-HT0367-150200-114-h04 HT0367 Homo 24
419625 U91616 Hs 91640 nuclear factor of kappa light polypeptid 24
440773 AA352702 Hs 332541 Homo sapiens, Similar to RIKEN cDNA 2700 24
450823 T81223 Hs 22011 complemeπt-c1q tumor necrosis factor-rel 24
447247 AW369351 Hs 287955 Homo sapiens cDNA FLJ13090 fis, clone NT 24
429109 AL008637 Hs 196352 neutrophil cytosolic factor 4 (40kD) 24
451802 AI817711 Hs 209374 ESTs 24
419417 R92491 Hs 39429 ESTs 24
407094 AF000574 Hs 22405 leukocyte immunoglobulin like receptor, 24
423567 BE252949 Hs 69331 hypothedcal protein FLJ 13633 24
427501 AI369280 Hs 131743 ESTs 24
451773 Z42044 Hs 26996 KIAA1278 protein 24
436845 AA732297 Hs 113928 ESTs 24
431584 AW296121 Hs 266263 Homo sapiens cDNA FLJ 14115 fis, clone MA 24
440614 AA781530 Hs 127236 hypothetical protein FLJ 12879 24
423721 AF176911 Hs 132004 cardiotrophiπ like cytokine, neurotrophi 24
452125 BE312642 Hs 28077 GDP-mannose pyrophosphorylase B 24
419508 AW997938 Hs 90786 ATP-bmding cassette, sub-family C (CFTR 24
453446 BE299996 gb 600944574F1 NIH MGC 17 Homo sapiens c 24
419792 AA250890 Hs 190037 ESTs 24
452786 R61362 Hs 106642 ESTs, Weakly similar to T09052 hypotheti 24
410447 AW816134 gb MR3-ST0220-290100 016-e04 ST0220 Homo 24
438662 AA223599 Hs 6351 cleavage and polyadenylation specific fa 24
402408 24
443950 NM.001425 Hs 9999 epithelial membrane protein 3 24
414625 AA335738 Hs 76686 glutathione peroxidase 1 24
403048 24
432088 AA525454 gb nι85c09 s1 NCI_CGAP_Pr20 Homo sapiens 24
431692 AL021331 Hs 267749 unc93 (C elegans) homolog A 24
455023 AW850907 gb lL3-CT0220-310100-065-H11 CT0220 Homo 24
426249 F05422 Hs 168352 nucleopoππ like protein 1 24
446795 AI797713 Hs 156471 ESTs 24
414774 X02419 Hs 77274 plasminogen activator, urokinase 24
414252 AA346483 Hs 126191 ESTs 24
417918 AA209205 Hs 163754 hypothetical protein FLJ 12606 24
427550 BE242818 Hs 179606 nuclear RNA helicase, DECD vanant of DE 24
404020 24
407846 AA426202 Hs 40403 Cbp/p300 interacting transacdvator, wit 24
417222 AI525424 Hs 42053 hypothedcal protein MGC2383 24
443639 BE269042 Hs 9661 proteasome (prosome, macropam) subunit 24
452706 AW449390 Hs 257150 ESTs, Moderately similar to SUR1_HUMAN S 24
401676 24 428882 AA436915 Hs 131748 ESTs, Moderately similar to ALU7 HUMAN A 24
436277 R88520 Hs 120917 ESTs 24
426271 AF026547 Hs 169047 chondroidπ sulfate proteoglycan 3 (neur 24
405353 24
409193 AA131483 gb zo08e05 r1 Stratagene πeuroepithelium 24
431431 AL096711 Hs 252953 Human DNA sequence from clone RP3-403A15 24
407889 R34556 Hs 30800 ESTs, Weakly similar to S65657 alpha-1 C- 24
453335 AW857376 Hs 169238 fucosyltraπsferase 3 (galactoside 3(4)-L 24
450621 AW297288 Hs 55918 hypothetical protein FU11354 24
419652 AL157485 Hs 91973 hypothetical protein 24
421151 BE174431 Hs 63386 ESTs 24
437846 AA773866 Hs 244569 esophagus cancer-related gene-2 24
420681 AA847602 Hs 106510 ESTs, Moderately similar to ALU2.HUMAN A 24
405288 24
453527 R49570 Hs 180236 ESTs 24
429875 AI091815 gb qa58b06 s1 Soares NhHMPu S1 Homosapi 24
436360 AI962796 Hs 136754 ESTs 24
418592 X99226 Hs 284153 Fancoπi anemia, complementation group A 24
419991 AJ000098 Hs 94210 eyes absent (Drosophila) homolog 1 24
449539 W80363 Hs 58446 ESTs 24
419870 AW403911 Hs 266175 phosphoprotein associated with GEMs 24
404584 24
454276 AW294996 Hs 255374 ESTs 24
423746 AW361817 Hs 132370 NADPH oxidase 1 24
415558 AA885143 Hs 125719 ESTs 24
428141 D50402 Hs 182611 solute earner family 11 (proton-coupled 24
406953 L36847 gb Human (clone p17/90) rearranged iduro 24
444471 AB020684 Hs 11217 KIAA0877 protein 24
451031 AI360187 Hs 4254 ESTs 24
455302 AW997641 gb RC6-BN0052-170200011-D06 BN0052 Homo 24
449063 AI627352 Hs 236547 Homo sapiens, clone IMAGE 2905978, mRNA, 24
401048 24
434420 AA688278 Hs 194864 hypothedcal protein FLJ22578 24
425848 BE242709 Hs 159637 valyl tRNA synthetase 2 24
449086 AI628357 Hs 208037 ESTs 24
415238 R37780 Hs 21422 ESTs 24
448337 AW206453 Hs 3782 ESTs 24
416991 N36389 Hs 141296 KIAA0226 gene product 23
412600 L28824 Hs 74101 spleen tyrosine kinase 23
418385 AW590613 Hs 301040 Homo sapiens, clone IMAGE 3357127, mRNA, 23
440769 BE561793 Hs 21446 KIAA1716 protein 23
450437 X13956 Hs 24998 hypothetical protein MGC10471 23
412035 N78559 Hs 293629 hypothedcal protein MGC3121 23
406739 AI566709 Hs 182426 πbosomal protein S2 23
418506 AA084248 Hs 85339 G protein-coupled receptor 39 23
410286 A1739159 Hs 61898 DKFZP586N2124 protein 23
443740 R56434 Hs 21062 ESTs 23
405605 23
416913 AW934714 gb RC1-DT0001-031299-011-a11 DT0001 Homo 23
426509 M31166 Hs 2050 pentaxiπ related gene, rapidly induced b 23
445828 F05802 Hs 81907 ESTs 23
457195 AB011099 Hs 196647 KIAA0527 protein 23
420372 AW960049 Hs 293660 Homo sapiens, clone IMAGE 3535476, mRNA, 23
423198 M81933 Hs 1634 cell division cycle 25A 23
457730 AW753613 gb RC1-CT0268 060100-013-e01 CT0268 Homo 23
412014 A1620650 Hs 43761 ESTs, Weakly similar to A46010 X-lmked 23
447131 NM 004585 Hs 17466 retinoic acid receptor responder (tazaro 23
446288 AWT89209 Hs 149708 ESTs 23
436954 AA740151 Hs 130425 ESTs 23
411658 AW855598 gb CM1-CT0278-031199-032-e08 CT0278 Homo 23
404240 23
456094 H95091 gb yw57a09 r1 Soares_placenta_8to9weeks_ 23
416951 AA190926 Hs 190785 ESTs, Moderately similar to S65657 alpha 23
406737 AI356586 gb qyl 51.09 1 NCI CGAP Brn23 Homo sapien 23
458453 AI097452 Hs 135095 ESTs 23
452330 AI879127 Hs 191979 KIAA1733 protein 23
408523 AW833259 Hs 314287 ESTs 23
455470 AW947992 gb PM0-MT0011-240300 001-c09 MT0011 Homo 23
436323 R17697 Hs 140963 ESTs, Weakly similar to I38022 hypotheti 23
450000 AI952797 Hs 10888 hypothetical protein FLJ21709 23
416171 H23896 Hs 125790 leucine πch repeat-containing 2 23
419134 T89863 Hs 221771 ESTs 23
445933 AV655733 Hs 293860 spinster-like protein 23
422089 AA523172 Hs 103135 ESTs, Weakly similar to SFR4 HUMAN SPLIC 23
449911 AI262106 Hs 12653 ESTs 23
417079 U65590 Hs 81134 interieukin 1 receptor antagonist 23
411742 AW247593 Hs 71819 eukaryotic translation initiation factor 23
435615 Y15065 Hs4975 potassium voltage gated channel, KQT-lik 23
423491 AA191765 Hs 129673 eukaryotic transladon initiation factor 23
407182 AA312551 Hs 230157 ESTs 23
411448 AA178955 Hs 271439 ESTs, Weakly similar to I38022 hypothed 23
438644 AI126162 Hs 129037 ESTs 23
432691 U29725 Hs 3080 mitogen acdvated protein kinase 7 23 452198 AI097560 Hs 61210 ESTs, Weakly similar to I38022 hypothed 23
411125 AA151647 Hs 68877 cytochrome b-245, alpha polypepdde 23
404054 23
430458 AA479300 Hs 225706 ESTs, Weakly similar to 138022 hypotheti 23
440210 AW674562 Hs 125296 ESTs 23
446727 AB011095 Hs 16032 KIAA0523 protein 23
453775 NM 002916 Hs 35120 replication factor C (activator 1) 4 (37 23
438379 N23018 Hs 171391 C-terminal binding protein 2 23
449919 AI674685 Hs 200141 ESTs 23
415293 R49462 Hs 106541 ESTs 23
441126 NM 000429 Hs 323715 methionine adenosyltransferase I, alpha 23
408203 AA053137 Hs 42390 nasophaiyngeal carcinoma susceptibility 23
434941 AW073202 Hs 334825 Homo sapiens cDNA FU14752 fis, clone NT 23
450748 AI733093 Hs 130016 ESTs 23
404185 23
418327 U70370 Hs 84136 paired-like homeodomain transcnpdon fa 23
451370 AI791929 Hs 300782 ESTs 23
400034 23
407723 AW071161 Hs 252873 ESTs 23
431320 AW969474 Hs 183070 ESTs 23
429271 AF039850 Hs 198515 dead πnger (Drosophιla)-lιke 1 23
453707 AW003879 Hs 126522 Homo sapiens, clone MGC 16722, mRNA, com 23
419225 U70073 gb HSU70073 Human Homo sapiens cDNA clon 23
444656 AI277924 Hs 145199 ESTs 23
405741 23
400917 23
432567 AA736777 Hs 293770 ESTs 23
437949 U78519 Hs 41654 ESTs, Weakly similar to A46010 X-lmked 23
450514 AC005785 Hs 25059 A kinase (PRKA) anchor protein 8 23
418400 BE243026 Hs 301989 KIAA0246 protein 23
444019 BE173977 Hs 10098 putative nucleolar RNA helicase 23
406326 23
412077 N51107 Hs 47199 ESTs, Weakly similar to FLJ00004 protein 23
427647 W19744 Hs 180059 Homo sapiens cDNA FLJ 20653 fis. clone KA 23
414528 AA148950 Hs 188836 ESTs 23
414854 BE546797 Hs 51483 ESTs, Weakly similar to hypothetical pro 23
420352 BE258835 gb 601117374F1 NIH MGC 16 Homo sapiens c 23
439467 AW292275 Hs 158365 ESTs 23
402627 23
451711 AK000461 Hs 26890 cat eye syndrome chromosome region, cand 23
424308 AW975531 Hs 154443 minichromosome maintenance deficient (S 23
423869 BE409301 Hs 134012 C1q-related factor 23
405915 23
431503 NM 012129 Hs 258576 claudin 12 23
423306 W88562 Hs 108198 ESTs 23
443232 AF161521 Hs 9081 phenylalanyl-tRNA synthetase beta-subuni 23
433064 D79991 Hs 30002 SH3-contaιπιng protein SH3GLB2, KIAA1848 23
434437 AI912566 Hs 187813 ESTs 23
436191 BE407866 Hs 170253 hypothedcal protein FU23282 23
420006 H14429 Hs 94300 serologically defined colon cancer andg 23
447942 F12628 Hs 334786 hypothedcal protein MGC16040 23
403166 23
422119 AI277829 Hs 111862 KIAA0590 gene product 23
403751 23
426451 AI908165 Hs 169946 GATA-binding protein 3 23
427413 BE547647 Hs 177781 hypothetical protein MGC5618 23
409091 AW970386 Hs 269423 ESTs 23
440491 R35252 Hs 24944 ESTs, Weakly similar to 2109260A B cell 23
427722 AK000123 Hs 180479 hypothedcal protein FU20116 23
405747 23
438210 AA780519 Hs 311601 EST 23
404652 23
423524 AF055989 Hs 129738 potassium voltage-gated channel, Shaw-re 22
426793 X89887 Hs 172350 HIR (histone cell cycle reguladon defec 22
444424 AI654684 Hs 196377 ESTs 22
434031 BE384165 Hs 23723 pseudoundylate synthase 1 22
427650 AW501245 Hs 252259 nbosomal protein S3 22
435220 D50030 Hs 104 HGF activator 22
438279 AA805166 Hs 154762 HIV-1 rev binding protein 2 22
424668 D83702 Hs 151573 cryptochrome 1 (photolyase-like) 22
429961 BE246829 Hs 226770 DKFZP566C0424 protein 22
442065 AI831229 Hs 128417 hypothedcal protein FLJ 14009 22
415198 AW009480 Hs 943 natural killer cell transcnpt 4 22
420536 AL117455 Hs 275438 histone deacetylase 7A 22
411263 BE297802 Hs 69360 kinesiπ-like 6 (mitotic centromere-assoc 22
443753 AW367578 Hs 134749 ESTs 22
423243 AA351938 Hs 23964 sιn3-assocιated polypeptide. 18kD 22
446572 AV659151 Hs 282961 ESTs 22
412247 AF022375 Hs 73793 vascular endothelial growth factor 22
421040 AA715026 Hs 135280 ESTs 22
426212 S71824 Hs 167988 neural cell adhesion molecule 1 22
455584 BE007420 gb PM3-BN0142-200300-001-C04 BN0142 Homo 22
406851 AA609784 Hs 180255 ma|or histocompadbility complex, class 22 444153 AK001610 Hs 10414 hypothetical protein FU 10748 22
419575 U43431 Hs 91175 topoisomerase (DNA) III alpha 22
418672 L44284 Hs 159743 ESTs 22
456261 AA210718 Hs 104157 ESTs, Weakly similar to KIAA0694 protein 22
415737 AA167626 Hs 118743 ESTs 22
447554 AI391598 Hs 36119 ESTs Weakly similar to ALU1_HUMAN ALU S 22
405159 22
442177 AW661820 Hs 211413 ESTs 22
446139 H77395 Hs 39749 ESTs 22
458339 AW976853 Hs 172843 ESTs 22
401876 22
439566 AF086387 gb Homo sapiens full length insert cDNA 22
425079 H09963 Hs 2257 vitronecdπ (serum spreading factor, som 22
441837 AA361743 Hs 179881 core-binding factor, beta subunit 22
430644 AB015419 Hs 247710 preproprolacdn-releasing pepdde 22
431474 AL133990 Hs 190642 ESTs 22
407739 NM M2285 Hs 38070 lymphoid nuclear protein related to AF4 22
424244 AV647184 Hs 143601 hypothedcal protein hCLA-iso 22
438057 AW294544 Hs 125785 ESTs, Weakly similar to CORB MOUSE CORNI 22
412715 NM.000947 Hs 74519 pπmase, polypepdde 2A (58kD) 22
422365 AF035537 Hs 115521 REV3 (yeast homolog)-lιke, catalydc sub 22
404170 22
406902 M32074 gb Human rednoic acid receptor gamma 2 22
437902 AA770599 Hs 144055 ESTs 22
401012 22
446502 AI302654 Hs 208024 ESTs 22
442554 AW467376 Hs 129640 ESTs 22
443021 AA3685-46 Hs 8904 lg superfamily protein 22
421141 AW117261 Hs 125914 ESTs 22
443070 BE388662 Hs 8984 Homo sapiens chromosome 14 BAC 98L12 22
446566 H95741 Hs 17914 membrane-spanning 4-domaιns, subfamily A 22
427695 R88483 Hs 172862 ESTs 22
426503 AA380153 gb EST93093 Skin tumor I Homo sapiens cD 22
431468 AW248431 Hs 256526 nuclear prelamin A recognidon factor 22
416185 AW975861 Hs 47367 KIAA1785 protein 22
437319 BE410958 Hs 56406 Homo sapiens cDNA FLJ13549 fis, clone PL 22
402064 22
413335 AI613318 Hs 48442 ESTs 22
408212 AA297567 Hs 43728 hypothedcal protein 22
406169 22
451099 R52795 Hs 25954 interieukin 13 receptor alpha 2 22
407335 AA631047 Hs 158761 Homo sapiens cDNA FU 13054 fis, clone NT 22
409715 W42591 Hs 23892 ESTs 22
431921 N46466 Hs 58879 ESTs 22
443823 BE089782 Hs 9877 hypothetical protein 22
432458 AI968598 Hs 78768 malignant cell expression-enhanced gene/ 22
419726 U50330 Hs 1274 bone morphogenetic protein 1 22
423178 AI033140 Hs 124983 Homo sapiens mRNA, cDNA DKFZp564C142 (fr 22
451089 AA9O3705 Hs 4190 Homo sapiens cDNA FU23269 fis, clone C 22
415216 AI825905 Hs 193211 Homo sapιens cDNA FU11421 fis. clone HE 22
442242 AV647908 Hs 90424 Homo sapiens cDNA FLJ23285 fis, clone H 22
441830 AA383104 Hs 42954 hypothedcal protein DKFZp564D0372 22
406660 X65371 Hs 172550 polypynmidine tract binding protein (he 22
443378 AW392550 Hs 9280 proteasome (prosome, macropain) subunit 22
432558 R97268 Hs 177269 ESTs 22
408146 R45621 Hs 81057 hypothetical protein MGC2718 22
419865 NM_007020 Hs 93502 U1-sπRNP binding protein homolog (70kD) 22
439444 AI277652 Hs 54578 ESTs, Weakly similar to I38022 hypotheti 22
438407 AI457122 Hs 129673 eukaryotic transladon initiation factor 22
450184 W31096 Hs 237617 Homo sapiens, clone IMAGE 3447394, mRNA, 22
409130 BE076601 Hs 75658 phosphon/lase, glycogen, brain 22
428844 AW972635 Hs 301904 hypothedcal protein FLJ 12671 22
429489 AF008203 Hs 204039 anstaless-like homeobox 3 22
433042 AW193534 Hs 281895 Homo sapιens cDNA FLJ11660 fis, cloπe HE 22
440658 H29142 Hs 143032 ESTs, Weakly similar to neuronal thread 22
408204 AA454501 Hs 43666 protein tyrosine phosphatase type IVA m 22
427498 NM_003926 Hs 178728 ethyl-CpG binding domain protein 3 22
408006 H57654 Hs 303345 ESTs, Weakly similar to I38022 hypothed 22
445703 AV654845 Hs 27 glycine dehydrogenase (decarboxyladng, 22
431446 AW294929 Hs 255369 Homo sapiens cDNA FU10265 fis. clone HE 22
456660 AA909249 Hs 112282 solute earner family 30 (zinc transport 22
433099 NM.002504 Hs 3187 nuclear transcnpdon factor, X-box bind 22
415857 AA866115 Hs 127797 Homo sapiens cDNA FU 11381 fis, clone HE 22
415245 N59650 Hs 27252 ESTs 22
443657 R14973 gb yf42(10 s1 Soares fetal liver spleen 22
402521 AW501216 Hs 108945 KIAA0515 protein 22
414819 BE177320 Hs 156148 hypothedcal protein FU 13231 22
446530 AV658909 Hs 282642 ESTs 22
415797 AI291896 Hs 72800 ESTs 22
414812 X72755 Hs 77367 onokine induced by gamma interferon 22
453028 AB006532 Hs 31442 RecQ protein-like 4 22
412133 U83460 Hs 73614 solute earner family 31 (copper transpo 22
407881 AW072003 Hs 40968 heparan sulfate (glucosamiπe) 3-0-sulfot 22 437033 AW248364 Hs 5409 RNA polymerase 1 subunit 22
422732 AA577455 Hs 24937 transformer-2 alpha (htra-2 alpha) 22
416388 AI417358 Hs 73677 ESTs 22
452849 AF044924 Hs 30792 hook2 protein 22
446615 BE513202 Hs 15589 PPAR binding protein 22
428361 NM.015905 Hs 183858 transcπpdonal intermediary factor 1 22
446279 AA490770 Hs 182382 ESTs 22
422938 NM_001809 Hs 1594 centromere protein A (17kD) 22
403969 22
410423 AW402432 Hs 63489 protein tyrosine phosphatase, non-recept 22
429736 AF125304 Hs 212680 tumor necrosis factor receptor superfami 22
447091 AW089648 Hs 157779 ESTs, Weakly similar to CA17_HUMAN COLLA 22
422017 NM 003877 Hs 110776 STAT induced STAT ιnhιbιtor-2 22
426728 NM.007118 Hs 171957 tπple funcdonal domain (PTPRF interact 22
438726 AB033103 Hs 6385 KIAA1277 protein 22
453315 BE544203 Hs 24831 ESTs 22
423244 AL039379 Hs 209602 ESTs, Weakly similar to ubiquitous TPR 22
433610 AA806822 Hs 112547 ESTs 22
429451 BE409861 Hs 202833 heme oxygenase (decycling) 1 22
417980 R32235 gb yh67f08 r1 Soares placenta Nb2HP Homo 22
406347 22
414406 BE297904 gb 601177814F1 NIH_MGC.17 Homo sapiens c 22
401827 22
446913 AA430650 Hs 16529 transmembrane 4 superfamily member (tetr 22
452294 AI871925 Hs 117895 ESTs, Moderately similar to A47582 B-cel 22
404084 22
456786 AK002084 Hs 132851 hypothedcal protein FU11222 22
435031 AI632091 Hs 116877 ESTs 22
442609 AL020996 Hs 8518 selenoprotein N 21
439732 AW629604 Hs 167641 hypothetical protein from EUROIMAGE 1703 2 1
421506 BE302796 Hs 105097 thymidine kinase 1, soluble 2 1
439253 AF086064 Hs 332252 ESTs 21
409669 AW177551 Hs 220255 hypothedcal protein MGC13098 2 1
429574 BE268321 Hs 208912 hypothedcal protein MGC861 2 1
437470 AL3901 7 Hs 134742 hypothedcal protein DKFZp547D065 21
408945 AW015089 Hs 4964 DKFZP586J1624 protein 2 1
447687 AI627947 Hs 150186 hypothedcal protein DKFZp566K1946 2 1
459584 AI910884 Hs 207898 ESTs 21
439130 AA306090 Hs 124707 ESTs 21
428180 AI129767 Hs 182874 guanine nucleotide binding protein (G pr 2 1
442028 AI239437 Hs 48945 ESTs 21
430968 AW972830 gb EST384925 MAGE resequences MAGL Homo 21
443609 AV650231 Hs 282941 ESTs, Highly similar to A Chain A, Human 2 1
417164 AA338283 Hs 81361 heterogeneous nuclear πbonucleoprotein 21
444534 AW271626 Hs 42294 ESTs 2 1
438391 AI262248 Hs 25027 ESTs 2 1
442003 AW297497 Hs 201891 ESTs 2 1
456278 BE300369 Hs 289038 hypothedcal protein MGC4126 2 1
416976 BE243985 Hs 80680 major vault protein 21
417810 D28419 Hs 82609 hydroxymethylbilane synthase 21
445242 BE156478 Hs 21108 ESTs, Weakly similar to ALU1 HUMAN ALU S 2 1
452712 AW838616 gb RC5-LT0054-140200-013-D01 LT0054 Homo 21
434926 BE543269 Hs 50252 mitochondπal πbosomal protein L32 21
421564 AB007864 Hs 105850 KIAA0404 protein 2 1
424927 AW973666 Hs 153850 hypothedcal protein C321D24 21
432742 AA564453 Hs 162339 ESTs 21
435958 H98180 Hs 117975 ESTs 21
421531 AA713505 Hs 291769 ESTs 21
410431 BE261320 Hs 158196 traπscπpdonal adaptor 3 (ADA3, yeast h 2 1
420503 AI570943 Hs 337546 ESTs 2 1
448127 AI478416 Hs 282883 ESTs, Weakly similar to ALU1_HUMAN ALU S 21
452897 BE066058 Hs 269233 ESTs, Moderately similar to I78885 serin 2 1
447112 H17800 Hs 7154 ESTs 2 1
406577 21
437162 AW005505 Hs 5464 thyroid hormone receptor coacbvadng pr 2 1
451460 AI797550 Hs 209652 ESTs 2 1
447402 H54520 Hs 18490 hypothedcal protein FU20452 21
435828 AA700705 Hs 13852 ESTs 2 1
436396 AI683487 Hs 152213 wingless-type MMTV integration site fami 21
420582 BE047878 Hs 99093 Homo sapiens chromosome 19, cosmid R2837 2 1
452020 AA722012 Hs 255757 ESTs, Weakly similar to AT2A.HUMAN POTEN 2 1
415586 Z45481 gb HSC2QE041 normalized infant brain cDN 2 1
452620 AA436504 Hs 119286 ESTs 2 1
457066 BE244613 Hs 158272 ESTs, Weakly similar to CA13 MOUSE COLLA 21
435472 AW972330 Hs 283022 tnggenng receptor expressed on myeloid 21
431741 AA51 783 Hs 191701 ESTs 2 1
446840 AW294828 Hs 209203 ESTs 21
440818 AI147060 Hs 146726 ESTs 21
410174 AA306007 Hs 59461 DKFZP434C245 protein 2 1
400822 2 1
412760 AW379030 Hs 41324 ESTs 21
410653 BE383768 Hs 65238 95 kDa rednoblastoma protein binding pr 21
426925 NM 001196 Hs 315689 Homo sapiens cDNA FU22373 fis, clone H 2 1 424242 AA337476 Hs 293984 hypothedcal protein MGC13102 2 1
452560 BE077084 Hs 336432 ESTs 2 1
456437 AI924228 Hs 115185 ESTs, Moderately similar to PC4259 fem 2 1
458922 BE501831 Hs 282053 ESTs 2 1
439231 AW581935 Hs 141480 Homo sapiens mRNA, cDNA DKFZp434N079 (fr 2 1
419488 AA316241 Hs 90691 nucleophosmm/nucleoplasmin 3 2 1
411829 AW865749 gb QV3-SN0021-100500-185-C03 SN0021 Homo 2 1
457192 AL135682 Hs 22452 Homo sapiens mRNA for KIAA1737 protein. 2 1
422128 AW881145 gb QV0-OT0033-010400-182-a07 OT0033 Homo 2 1
452571 W31518 Hs 34665 ESTs 2 1
423699 H41850 Hs 131846 PCAF associated factor 65 alpha 2 1
406610 2 1
453638 AW814996 gb MR1-ST0206-170400-024-h09 ST0206 Homo 2 1
418856 AA362858 gb EST72900 Ovaiy II Homo sapiens cDNA 5 21
437623 D63880 Hs 5719 chromosome condensation-related SMC-asso 2 1
410908 AA121686 Hs 10592 ESTs 2 1
420221 N25991 Hs 43725 ESTs 2 1
424739 AA346108 Hs 221610 ESTs 21
425398 AL049689 Hs 156369 hypothetical protein similar to tenascin 2 1
424901 Z11933 Hs 182505 POU domain, class 3, transcnpdon facto 2 1
411096 U80034 Hs 68583 mitochondπal intermediate pepddase 21
415635 F13168 gb HSC3JF101 normalized infant brain cDN 2 1
418181 U37012 Hs 83727 cleavage and polyadenylation specific fa 2 1
407103 AA424881 Hs 256301 hypothedcal protein MGC13170 2 1
454389 AW752571 gb IL3-CT0213-170100-O55-F02 CT0213 Homo 21
400021 2 1
439228 N51700 gb yy72d01 s1 Soares uldple sclerosis 2 1
456505 AA504595 Hs 111418 ESTs 21
405258 2 1
444645 AI184564 Hs 101654 ESTs 2 1
430246 AI269069 Hs 109268 hypothedcal protein FU 12552 2 1
458687 AW024815 Hs 170088 GLUT4 enhancer factor 2 1
403857 2 1
400258 2 1
422221 AA306649 Hs 169370 FYN oncogene related to SRC, FGR, YES 2 1
441054 AA913591 Hs 126480 ESTs 2 1
452700 AI859390 Hs 288940 five-span transmembrane protein M83 2 1
454606 AW809752 gb MR4-ST0124-181299-020-b06 ST0124 Homo 2 1
448954 AB014564 Hs 22616 KIAA0664 protein 21
443148 AI034357 Hs 211194 ESTs, Weakly similar to ALU8.HUMAN ALU S 2 1
453486 AL039201 Hs 173554 ubiquinol-cytochrome c reductase core pr 2 1
437695 AA769202 Hs 192142 ESTs 2 1
425449 X52056 Hs 157441 spleen focus forming virus (SFFV) provir 2 1
447270 AC002551 Hs 331 general transcnpdon factor IHC, polyp 2 1
435677 AA6941 2 Hs 293726 ESTs, Weakly similar to TSGA RAT TESTIS 21
436382 AW977063 Hs 250181 ESTs 2 1
435837 AI689210 Hs 187276 Homo sapiens cDNA FU11431 fis, clone HE 2 1
458287 AA987556 Hs 12867 ESTs 21
423794 BE551781 Hs 231895 ESTs 21
408049 AW076098 Hs 74316 desmoplakin (DPI, DPII) 2 1
402721 2 1
451999 AW176401 Hs 27424 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 2 1
417541 AI992191 Hs 180040 hypothedcal protein FU22439 21
414857 AW402389 Hs920 modulator recognidon factor I 2 1
435760 AF231922 Hs 213004 chromosome 21 open reading frame 62 2 1
428086 AL110193 Hs 224137 hypothetical protein 21
447853 AI434204 Hs 164285 ESTs, Weakly similar to AFG1.YEAST AFG1 2 1
419034 NM 002110 Hs 89555 hemopoiedc cell kinase 2 1
431019 NM 005249 Hs 2714 forkhead box G1B 21
421064 AI245432 Hs 101382 tumor necrosis factor, alpha-induced pro 2 1
416435 AI431301 Hs 179703 KIAA0129 gene product 2 1
437014 AA808757 Hs 222531 ESTs Weakly similar to S59501 interfero 21
459369 T83080 gb yd40e03 r1 Soares fetal liver spleen 2 1
402239 2 1
412280 AW205116 Hs 272814 hypothedcal protein DKFZp434E1723 2 1
426012 AA367507 Hs 75874 pregnancy-associated plasma protein A 2 1
438885 AI886558 Hs 184987 ESTs 21
426076 AW962714 gb EST374787 MAGE resequences, MAGG Homo 2 1
404561 2 1
442932 AA457211 Hs 8858 bromodomain adjacent to zinc finger doma 2 1
408175 W29089 Hs 19066 hypothedcal protein DKFZp66702 16 2 1
423867 AA331886 gb EST35757 Embryo, 8 week 1 Homo sapien 21
458604 W37944 Hs 4007 Sarcolemmal-associated protein 2 1
409650 T08490 Hs 288969 HSCARG protein 2 1
401729 2 1
433675 AW977653 Hs 75319 nboπucleodde reductase M2 polypeptide 2 1
456741 W37608 Hs 184492 ESTs 2 1
417037 BE083936 Hs 80976 andgen identified by monoclonal andbod 21
415079 R43179 Hs 22895 hypothedcal protein FU 23548 21
439262 AA832333 Hs 333045 ESTs 2 1
403108 2 1
436718 AW015227 Hs 289053 hypothetical protein FU14733 21
440696 AI762757 Hs 187660 putative Rab5 GDP/GTP exchange factor ho 21 409745 AA077391 gb 7B14E12 Chromosome 7 Fetal Brain cDNA 2 1
453485 BE620712 Hs 33026 hypothedcal protein PP2447 2 1
418177 N44967 Hs 5663 ESTs 2 1
457292 AI921270 Hs 334882 hypothedcal protein FLJ14251 2 1
454434 AA083558 Hs 261286 ESTs 2 1
406085 2 1
424441 X14850 Hs 147097 H2A histone family, member X 2 1
422726 U11690 Hs 1572 faciogenital dysplasia (Aarskog-Scott sy 2 1
424576 BE154142 Hs 96833 ESTs 2 1
423660 AL045228 Hs 130831 Homo sapiens mRNA, cDNA DKFZp434L137 (fr 2 1
403509 AF231919 Hs 18759 KIAA0539 gene product 2 1
441940 AW298115 Hs 128152 ESTs 2 1
439190 AW978693 Hs 293811 ESTs 2 1
417791 AW965339 Hs 111471 ESTs 2 1
423701 AA329856 Hs 143022 ESTs 2 1
427239 BE270447 Hs 174070 ubiquitin earner protein 2 1
459642 BE243103 gb TCAAP2E0949 Pediatπc acute myelogeno 2 1
450385 AI631024 Hs 24948 synuclein, alpha interacting protein (sy 2 1
425159 NM 004341 Hs 154868 caώamoyl-phosphate synthetase 2, aspart 2 1
425591 AW294734 Hs 279727 Homo sapiens cDNA FU14035 fis, clone HE 2 1
445101 T75202 Hs 12314 Homo sapiens mRNA, cDNA DKFZp586C1019 (f 2 1
412811 H06382 Hs 21400 ESTs 2 1
426369 AF134157 Hs 169487 Kreisler (mouse) maf-related leucine zip 2 1
435924 AW029203 Hs 191952 ESTs 2 1
418388 R72332 Hs 29258 Homo sapiens cDNA FU11364 fis, clone HE 2 1
452235 AL039743 Hs 28514 testes development-related NYD-SP21 2 1
452313 Y00486 Hs 28914 adenine phosphonbosyltransferase 2 1
450704 H85157 Hs 40696 ESTs 2 1
427539 AA405205 Hs 97960 ESTs, Weakly similar to T51146 πng-box 2 1
402028 2 1
405362 2 1
414718 H95348 Hs 107987 ESTs 2 1
433424 R68252 Hs 163566 ESTs 2 1
444875 AI200759 Hs 44737 ESTs 20
449523 NM 000579 Hs 54443 chemokine (C-C modf) receptor 5 20
456072 H54381 gb yq89a03 s1 Soares fetal liver spleen 20
436331 AI239495 Hs 120189 ESTs 20
448418 Z43704 Hs 21192 Homo sapiens clone 25155 mRNA sequence 20
447250 AI878909 Hs 17883 protein phosphatase 1G (formeriy 2C), ma 20
448192 R43915 Hs 4958 ESTs 20
448966 AW372914 Hs 86149 phosphoinositol 3-phosphate binding prot 20
408605 AF025374 Hs 46465 T-cell, immune regulator 1 20
410790 AW803357 gb IL2-UM0079-090300-050-A08 UM0079 Homo 20
436872 X15624 gb Human H1 RNA 20
432238 AL133057 Hs 274135 Homo sapiens mRNA, cDNA DKFZp434K1815 (f 20
446307 T50083 Hs 9094 ESTs 20
436588 AA759233 Hs 126506 ESTs 20
452487 AW207659 Hs 6630 Homo sapiens cDNA FU13329 fis, clone OV 20
430420 AW140027 Hs 26373 Homo sapiens cDNA FU23449 fis, clone H 20
432036 AF224266 Hs 272373 interieukin 20 20
414460 L00727 Hs 898 dystrophia myotonica-protein kinase 20
433507 AI817336 Hs 191791 ESTs 20
427964 AA418082 Hs 98286 ESTs, Weakly similar to T20655 hypotheti 20
443108 W86975 Hs 203707 ESTs 20
434504 AI887341 Hs 121590 hypothedcal protein FU 12827 20
454310 AW818390 Hs 175613 homolog of Xenopus Claspin 20
443566 AI290284 Hs 159872 ESTs 20
449722 BE280074 Hs 23960 cyclin B1 20
452682 AA456193 Hs 9071 progesterone membrane binding protein 20
412362 AW945484 Hs 184252 ESTs, Weakly similar to ALU8.HUMAN ALU S 20
429341 X73874 Hs 2393 phosphoiγlase kinase, alpha 1 (muscle) 20
435863 AF255346 Hs 62919 Juπ dimeπzation protein p21SNFT 20
400774 R58624 Hs 2186 eukarγodc translation elongadon factor 20
453944 AW975369 Hs 292570 Homo sapiens, clone IMAGE 3502107, mRNA 20
419227 BE537383 Hs 89739 choliπenjic receptor, nicotinic beta po 20
448529 T26460 Hs 22550 ESTs 20
443206 AB011420 Hs 9075 seπne/threonine kinase 17a (apoptosis-i 20
439360 AA448488 Hs 336629 πbosomal protein L44 20
436660 AI658870 Hs 184513 ESTs 20
449030 AI365582 Hs 57100 Homo sapiens mRNA for FU00016 protein. 20
411048 AK001742 Hs 67991 hypothetical protein DKFZp434G0522 20
406624 AF052762 gb Homo sapiens clone csneg8-1 immunoglo 20
450666 T99968 Hs 18799 ESTs, Weakly similar to 138022 hypotheti 20
446143 BE245342 Hs 306079 sec61 homolog 20
437698 R61837 Hs 7990 ESTs, Moderately similar to I84505 calci 20
426607 AA382330 Hs 124223 ESTs 20
449246 AW411209 Hs 23363 hypothedcal protein FU 10983 20
422564 AI148006 Hs 222120 ESTs 20
432682 AI376400 Hs 159588 ESTs 20
422140 BE295918 Hs 112193 mutS (E coli) homolog 5 20
408215 BE614290 Hs 43812 syntaxin 10 20
417129 AI381800 Hs 300684 calcitonin gene-related peptide-receptor 20
442772 AW503680 Hs 5957 Homo sapiens clone 24416 mRNA sequence 20 434928 AW015595 Hs 4267 Homo sapiens clones 24714 and 24715 mRNA 20 411380 AW841619 gb RC1-CN0017-120200-012-b09 CN0017 Homo 20 430603 AA148164 Hs 247280 HBV associated factor 20 425905 AB032959 Hs 318584 novel C3HC4 type Zinc finger (πng finge 20 401125 20 412939 AW411491 Hs 2186 eukaryodc translation eloπgadon fxtor 20 448740 BE250632 Hs 8026 sestπn 2 20 454390 AB020713 Hs 56966 KIAA0906 protein 20 415012 NM.004383 Hs 77793 c-src tyrosine kinase 20 410407 X66839 Hs 63287 carbonic anhydrase IX 20 403478 20 456485 AI393037 Hs 97871 Homo sapiens, clone IMAGE 3845253, mRNA, 20 430294 AI538226 Hs 32976 guanine nucleotide binding protein 4 20 411669 BE612676 Hs 303116 stromal cell-deπved factor 2-lιke 1 20 451944 AW445218 Hs 210876 ESTs 20 436395 AJ227900 gb Homo sapiens partial mRNA ID EE2-16B 20 456457 AA252905 Hs 194477 E3 ubiquitin ligase SMURF2 20 449123 D50920 Hs 23106 KIAA0130 gene product 20 409214 AW405967 Hs 333388 Homo sapiens, clone IMAGE 3957135, mRNA, 20 437619 AW351491 Hs 334853 hypothedcal protein FU23544 20 453348 BE272318 Hs 8595 hypothetical protein FU 12438 20 424382 AA351898 Hs 23539 ESTs 20 447079 AA280057 Hs 105280 ESTs, Weakly similar to dJ963K232 [H sa 20 449501 AI652924 Hs 231942 ESTs 20 422893 X98411 Hs 121555 myosin IF 20 412125 Y17114 Hs 73393 eyes absent (Drosophila) homolog 4 20 434845 BE267057 Hs 325321 hypothedcal protein R32184.1 20 410422 AL042014 Hs 334698 Homo sapiens, clone MGC 15203, mRNA, com 20 430255 AK000703 Hs 323822 Homo sapiens mRNA for KIAA1551 protein, 20 451656 BE327088 Hs 212752 ESTs 20 442068 BE312873 Hs 314932 ESTs 20 446846 AW197626 Hs 271901 ESTs, Moderately similar to S08686 finge 20 442690 AI01 727 Hs 160047 ESTs, Weakly similar to B28096 lιne-1 pr 20 454277 AW295069 Hs 31743 ESTs, Weakly similar to Z157.HUMAN ZINC 20 426910 AA470023 Hs 190089 ESTs, Moderately similar to ALU1.HUMAN A 20 402798 20 404554 20
TABLE 9B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
407909 1025254J AW103986 BE156395 BE156391 BE156190 BE156184 BE156388 BE156394
408432 1058667 1 AW195262 R27868 AW811262
409193 110747 1 AA131483 AA065156 AA076448
409745 115237 1 AA077391 AI347618 AI361453 AI088754 AW207491 AW960912 AA921874 AA286833 AA150722 BE152353 AW188822 BE152450
410447 1203929 1 AW816134 BE063456 AW748795 BE150839
410790 1221131 1 AW803357 AW803423 AW812233 R06814
411256 1236790 1 AW834039 AW834040 AW834047 AW845410 BE003128 AW852479
411380 1242343 1 AW841619 AW851958AW851851 AW851985
411632 1252361.1 AW854829 AW854805 AW854841 AW854825 AW854822 AW854830 AW854835 AW854826
411658 1252987 1 AW855598 AW855608 BE148763 BE148764 AW855645 AW855615 AW855596 AW855610 AW855601 AW855605
411829 1260309.1 AW865749 BE179419 BE179492
412225 1284108 1 AW902042 N77591
412370 1291952 1 AW946614 AW946622 AW946663 AW946667 AW946615 AW946619
412391 1292625 1 AW947710 AW947698 AW947697 AW947713
413257 1355963 1 BE075035 BE074999 BE075006 BE075005 BE075032 BE075008 BE075037
413604 1379715 1 R51767 BE152515 Z44834 H23397
414406 1443333 1 BE297904 BE294312
414550 1460990 -1 BE379808
415346 1534581 1 Z43108 F06295 R13085
415406 1536026.1 T26510 F07926 R53367
415586 1540116 1 Z45481 F12393 T74437
415635 1540853 1 F13168 R21289 T77628
416871 1626761 1 H98716 N90792 N24283
416913 163001 1 AW934714 BE161007 BE162500 AW749902 AW749864 BE162498 BE161005 AA190449 AW513465 BE161006 BE162499
417980 1712954 1 R32235 R32247 R32219
418333 173.2 W92113 AA702794 BE044316 W91984 AA679375 T94184 AA679335 BE503126 AW502118 BE467367 AA584550 AW139964 R93353 AW088477
AI887846 AW502624 W81697 W81696 AA447817 AA447667 F13631 AW268271 AA055366 AW629027 AA677404 AA831618 AI124782 AA889402
AA765804 AA765530 AA055698 AA594019 AI267368 AA456946 R93354 AF264624 AW668618 AA601493
418856 179649.1 AA362858 AW863761 AA229428 419217 182954 1 AA504571 AA235243 AA411737 AW969068 AA406543 419225 1830274 -1 U70073 419311 183793 1 AA689591 AW974261 AA236240 AI077451 AA631399 AW974262 420352 192979 1 BE258835 AW968316 AA258918 AW843305 R14744 AI580388 BE071923 R36280 422128 211994 1 AW881145 AA490718 M85637 AA304575 T06067 AA331991 422156 212379.1 N34524 AA305071 AW954803 AA502335 AI433430 AI203597 AW026670 AW265323 AW850787 AA317554 AW993643 AW835572 AW385512
AI334966 W32951 H62656 H53902 R88904 AW835732
422176 212714.1 H80977 BE147695 AA305496 AW962366 AA436754 423756 231725.1 AA828125 AA834883 AA330555 423867 232732 1 AA331886 AW962659 AW962655 T89841 425189 247825.1 H16622 R17322 AA351959 425517 252729.1 AF121179 BE162736 AA358827 426076 260504.1 AW962714 AA369277 AA369278 426413 266650.1 AA377823 AW954494 AI022688 426503 268283.1 AA380153 AA380233AW963529 426531 268760.1 AA381071 AA381084 AA380862 429875 310034.1 AI091815 AA460162 AA460761 430968 326269.1 AW972830 AA527647 AA489820 AA570362 432088 341195.1 AA525454 H74039 R89502 T77379 433532 368950.1 AW975367 AA598607 AA742735 434559 38889.1 AF147315 AW173079 T53029 435065 399329.1 BE064391 BE064395 AA663613 N99644 436190 41555.1 AK001059 AA633055 436395 41905 1 AJ227900 AI094933 AW051119 F00947 436532 421802.1 AA721522 AW975443 T93070 436722 425758.1 AW975977 AA729469 AA747132 436872 42851.-1 X15624 437034 431713.1 AA742643 AA808575 AW976668 439086 46852.1 AF085947 H70981 H78989 439228 47001.1 N51700 AF086051 N51792 439518 47334.1 W76326 AF086341 W72300 439546 47360.1 AF088056 W76297 W72448 439566 47387.1 AF086387 W77884 W72711 439710 47550 1 AF086543 W96291 W96225 443657 576685.1 R14973 R14967 AI081006 444168 593829.1 AW379879 AI126285 H12014 444386 604004.1 BE065183 AI144398 BE065367 451129 859870.1 BE072881 BE072946 AI762181 452712 928309.1 AW838616 AW838660 BE144343 AI914520 AW888910 BE184854 BE184784 453446 967533.1 BE299996 BE297115 BE270415 BE295214 BE296526 453638 975649.1 AW814996 AL047199 AW850979 453746 979731.1 AL120611 BE006190 BE006189 454377 114761.1 AA076811 AW814764 454389 115682.1 AW752571 AW847602 AA077979 454606 1226149.2 AW809752 AW810271 AW809944 AW810319 AW810215 AW810368 AW810167 454630 1227352.1 BE142075 BE142148 BE142189 AW816249 BE142147 BE142002 BE142406 BE142094 BE142020 BE142074 BE142347 BE142000 BE142375
AW811189 BE142133
454631 1227443.1 AW811324 AW811325 AW811326 AW811333 AW811329 AW811328 AW811332 AW811339 AW811335 454679 1228929.1 AW813110 AW813113 454967 1247021.1 AW848276 AW848416 AW848160 AW847945 AW847947 AW848063 AW848113 455023 1249188.1 AW850907 AW850901 AW850877 455302 1276542.1 AW997641 AW891777 455470 1292849.1 AW947992 AW947967 AW947950 AW947957 AW947953 AW947973 AW947966 AW947971 AW947947 AW947970 AW947995 AW947979 AW947952
AW947956
455514 1321649.1 AW983871 BE090302 AW983867 AW983845 AW983860 AW983853 AW983852 455530 1322298.1 AW984744 AW984759 455584 1334741.1 BE007420 BE007419 BE007421 BE007422 455778 1364506J BE088746 BE088802 BE088755 BE088876 BE088947 BE088881 BE088952 455908 1382301.1 BE156306 BE156188 BE156298 BE156377 BE156374 456072 1470256.1 H54381 H54463 BE393262 456094 1504780.1 H95091 C01228 457374 328758.1 AA493662 AW897396 BE154814 457578 359618.-1 AA578027 457730 393905 1 AW753613 AW753857 BE150374 BE150693 BE150394 AA808851 AA650159 AA654653 BE150419
TABLE9C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham, et al " refers to the publication endded "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted Nt.posi on Indicates nucleodde positions of predicted exons
Pkey Ref Strand NLposition
400822 7465000 Plus 186223-186402, 186878-187275
400859 9757499 Minus 91888-92018,98131-98294,99474-99570
400917 7283186 Minus 173258-173631
400992 8096828 Plus 140390-140822
401012 7230838 Minus 736-1137
401048 7232177 Plus 132430-132761
401125 8570296 Minus 126863-126984
401324 9863791 Plus 234057-234174
401384 6850939 Minus 58360-58545
401558 7139678 Plus 103510-104090
401626 8575943 Minus 238100-238432
401676 9965536 Plus 3891-4691
401714 6715702 Plus 96484-96681
401729 8134856 Minus 90651-90878
401827 2262095 Plus 94725-94860,98452-98660
401876 8099107 Plus 95913-96641
402028 7139781 Plus 88749-89237
402064 8117294 Plus 100159-100350,100445-100912
402239 7690131 Plus 38175-38304,42133-42266
402408 9796239 Minus 110326-110491 402424 9796344 Minus 64925-65073
402516 9798099 Minus 195342-195511
402604 9909420 Plus 20393-20767
402627 9931216 Plus 12136-12272,16487-16628 17654-17798,18494-18621,18933-19089,20669-20790,21134-21298,22866-22973,23686-23820 26626- 26895,29279-29469
402721 8969253 Minus 144428-144715
402798 3355547 Plus 23596-23867
402856 9801288 Minus 90119-90411
403048 4210991 Plus 44275-44592,49656-49955
403108 8980955 Plus 93253-93667
403142 9444521 Plus 89286-90131
403166 9838127 Minus 67762-67940.68695-68856,70394-70507
403478 9958258 Plus 116458-116564
403680 7331517 Minus 157184-157415
403751 7229815 Minus 158794-160929
403790 8084957 Minus 87826-87947,89835-90002
403797 8099896 Minus 123065-125008
403857 7708910 Minus 2524-3408
403881 7710245 Minus 107250-107685,108924-109213
403961 7596976 Minus 110393-110603
403969 8569909 Plus 31237-31375,32405-32506
404020 8655966 Minus 174449-174663
404054 3548785 Plus 66713-69175
404084 9944055 Plus 2795-2969
404108 8247074 Minus 63603-64942
404170 9930793 Plus 168836-169248
404185 4572584 Minus 129171-129327
404240 5002624 Minus 116132-116407,116653-116922
404295 9856663 Minus 75747-75947
404299 5738652 Minus 3826-4025
404366 9964977 Plus 96589-96801
404554 7243881 Plus 42637-42839
404561 9795980 Minus 69039-70100
404584 9857511 Plus 138651-139153
404589 9931665 Minus 32824-32985
404642 9796810 Plus 102999-103145
404652 9796969 Minus 108172-108296
404721 9856648 Minus 173763-174294
404756 7706327 Plus 82849-83627
404802 4581357 Minus 30093-30600
404984 6939882 Plus 87221-87505
405159 9966252 Plus 79659-79804
405258 7329310 Plus 129930-130076
405288 6139075 Minus 126268-126436
405353 2811095 Plus 118525-118892
405362 2337862 Minus 105008-105142,105980-106091 140445-140556,142519-142641
405558 1621110 Plus 4502-4644,5983-6083
405588 5002511 Plus 46180-46366
405605 5836195 Minus 117070-117270
405701 4263751 Plus 93243-93364
405741 9966947 Minus 156747-156875, 156936-157208
405747 8469069 Minus 153933-154060
405771 7018349 Plus 91191-91254,91510-91589
405808 9929207 Plus 109758-111166
405884 6758747 Plus 62383-62583
405915 7712162 Minus 43717-43859
406028 8312303 Minus 177469-177829
406085 9123888 Plus 18665-18843
406169 6684220 Minus 12620-14251
406267 7528342 Minus 2570-2731
406326 9212385 Plus 84508-84655
406347 9255981 Plus 90900-91091
406474 9795567 Plus 52758-53211
406577 7711730 Plus 11377-11509
406610 8312226 Plus 13096-13334
TABLE 10A ABOUT 582 GENES SIGNIFICANTLY DOWN-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS TISSUES
Table 10A lists about 582 genes significandy down-regulated in glioblastoma compared to nomial adult CNS dssues These were selected from 59680 probesets on the
Affymetnx/Eos Hu03 GeneChip anay such that the rado of "average" normal CNS to "average" glioblastoma was greater than or equal to 3 The "average" normal CNS level was set to the 75th percendle amongst vaπous normal CNS dssues The "average" glioblastoma level was set to the 85th percendle amongst vaπous tumor samples In order to remove gene-specific background levels of non-specific hybndization the 10th percendle value amongst various non-malignant tissues was subtracted from both the numerator and the denominator before the rado was evaluated
Pkey Unique Eos probeset identifier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dtle
R1 Ratio of 75th percendle normal central nervous system dssue to 85th percendle tumor
Pkey ExAccn UnigenelD Unigene Title R1
453655 AW960427 Hs 79059 transforming growth factor, beta recepto 1367
417275 X63578 Hs 295449 paivalbumm 290
430829 AW451999 Hs 194024 ESTs 257 410657 AF063228 Hs 65248 dyπeiπ, cytoplasmic, intermediate polype 226
419954 D14720 Hs 93883 myelin protein zero (Charcot-Maπe-Tooth 21 2
459247 N46243 Hs 110373 ESTs, Highly similar to T42626 secreted 185
416133 NM.001683 Hs 89512 ATPase Ca++ transporting, plasma membra 15 5
416018 AW138239 Hs 78977 proprotein convertase subdlisin/kexin t 152
417167 AW206437 Hs 4290 ESTs 148
433940 H05129 Hs 7459 cyclic AMP-regulated phosphoprotein, 21 134
413324 V00571 Hs 75294 corticotropin releasing hormone 13 1
439830 AA846666 Hs 151489 ESTs, Weakly similar to XE7 HUMAN PROTEI 126
408068 AW148652 Hs 167398 ESTs 126
412636 NM.004415 Hs 74316 desmoplakm (DPI, DPII) 125
429096 AB011106 Hs 196012 KIAA0534 protein 12 2
412638 AA910199 Hs 203838 ESTs 12 2
423690 AA329648 Hs 23804 ESTs, Weakly similar to PN0099 son3 prot 12 1
456844 AI264155 Hs 152981 CDP-diacylglycerol synthase (phosphadda 11 9
418318 U47732 Hs 84072 transmembrane 4 superfamily member 3 109
442593 R39804 Hs 31961 ESTs 108
446353 AI290919 Hs 153661 ESTs 104
420290 AW977318 Hs 194480 ESTs 103
414220 BE298094 gb 601118231F1 NIH MGC 17 Homo sapiens c 103
414290 AI568801 Hs 71721 ESTs 10 2
426365 AA376667 Hs 10283 RNA binding modf protein 8B 100
414937 R38698 Hs 12382 ESTs 100
419643 F06066 Hs 91791 chromosome 11 open reading frame 25 95
407173 T64349 gb yc10d08 s1 Stratagene lung (937210) H 95
412454 R55745 Hs 167330 ESTs 95
439366 AF100143 Hs 6540 fibroblast growth factor 13 94
415315 F12240 Hs 250655 prothymosin, alpha (gene sequence 28) 93
441790 AW294909 Hs 132208 ESTs 92
448117 H49129 Hs 172982 ESTs 9 1
400661 90
433558 AA833757 Hs 201769 ESTs, Weakly similar to T24435 hypothed 90
412453 R20205 Hs 167330 ESTs 90
408920 AL120071 Hs 48998 fibronectin leucine rich transmembrane p 89
409031 AA376836 Hs 76728 ESTs 87
428106 BE620016 Hs 182470 PTD010 protein 83
446544 AI631932 Hs 7047 ESTs, Weakly similar to Unknown [H sapie 82
423479 NM 014326 Hs 129208 death-associated protein kinase 2 82
439480 AL038511 Hs 125316 ESTs, Weakly similar to S33990 finger pr 82
418036 Z37976 Hs 83337 latent transforming growth factor beta b 80
456490 U83171 Hs 97203 small inducible cytokine subfamily A (Cy 80
410200 AA082557 Hs 101915 Stargardt disease 3 (autosomal dominant) 80
414602 AW630088 Hs 76550 Homo sapiens mRNA, cDNA DKFZp564B1264 (f 80
408428 NM 014787 Hs 44896 DnaJ (Hsp40) homolog, subfamily B, membe 79
437073 AI885608 Hs 94122 ESTs 79
408434 AW195317 Hs 107716 hypothetical protein FLJ22344 79
438150 AA037534 Hs 79059 transforming growth factor, beta recepto 79
440209 H05049 Hs 22269 neurexin 3 78
408119 W26213 Hs 101672 ESTs, Weakly similar to T00331 hypothed 78
417421 AL138201 Hs 82120 nuclear receptor subfamily 4, group A, m 78
410587 AA370706 Hs 86412 chromosome 9 open reading frame 5 78
429611 AI889077 Hs 211388 Homo sapiens BAC clone CTB-60N22 from 7q 77
405800 77
421750 AK000768 Hs 107872 hypothedcal protein FLJ20761 77
426356 BE536836 Hs 98682 hypothetical protein FKSG32 77
423440 R25234 Hs 143434 contacdn 1 77
445148 AI214510 Hs 146304 ESTs 76
416294 D86980 Hs 79170 KIAA0227 protein 76
424087 N69333 Hs 143434 contacdn 1 76
437479 R61866 Hs 101277 ESTs 75
405071 75
421224 AW402154 Hs 125812 ESTs 74
442025 AW887434 Hs 11810 CDA11 protein 74
459476 BE185844 gb IL5-HT0731-110500-087-C08 HT0731 Homo 72
430573 AA744550 Hs 136345 ESTs 7 1
401836 7 1
448958 AB020651 Hs 22653 KIAA0844 protein 71
430152 AB001325 Hs 234642 aquaponn 3 7 1
419474 AW968619 Hs 155849 ESTs 7 1
401780 7 1
446052 AA358760 gb EST67699 Fetal lung II Homo sapiens c 70
423605 AF047826 Hs 129887 cadhenn 19, type 2 70
433098 AW190593 Hs 151143 ESTs 70
449511 AI436187 Hs 296261 guanine nucleotide binding protein (G pr 69
451285 AW137912 Hs 227583 Homo sapiens chromosome X map Xp11 23 L- 68
428414 AL049980 Hs 184216 DKFZP564C152 protein 68
419273 BE271180 Hs 293490 ESTs, Weakly similar to I38022 hypothed 68
443155 R54485 Hs 23772 ESTs 68
450561 R49674 Hs 25909 ESTs 68
433068 NM 006456 Hs 288215 sialyltransferase 68
440729 AA904739 Hs 128204 ESTs 68
448426 BE018315 Hs 280776 tankyrase, TRF1-ιnteractιng ankyπn-rela 67
423589 AA328082 Hs 209569 ESTs 66 415681 AI379882 Hs 72630 ESTs 65
413510 F13044 gb HSC3HH101 normalized infant bran cDN 64
427992 Y15014 Hs 181353 UDP-Gal betaGlcNAc beta 1 3-galactosyttr 64
453344 BE349075 Hs 44571 ESTs 64
450642 R39773 Hs 7130 copine IV 64
432251 AW972983 Hs 232165 polycythemia rubra vera 1, cell surface 64
429322 D86984 Hs 199243 KIAA0231 protein 64
444927 AW016637 Hs 199425 ESTs 64
447482 AB033059 Hs 18705 KIAA1233 protein 64
400332 S66407 Hs 248032 FLT4 63
440703 AL137663 Hs 7378 Homo sapiens mRNA, cDNA DKFZp434G227 (fr 63
446129 AW244073 Hs 145946 ESTs 63
454076 AW204712 Hs 61957 ESTs 63
425526 AA359933 gb EST69040 Fetal lung II Homo sapiens c 63
421913 AI934365 Hs 109439 osteoglycin (osteoinducdve factor, mime 63
434273 AA913143 Hs 26303 ESTs 62
408480 AI350337 Hs 164568 fibroblast growth factor 7 (keradnocyte 62
451301 AI769514 Hs 209890 EST 62
430754 AW862610 Hs 157068 ESTs 62
438356 AA805530 Hs 48527 ESTs 62
422743 BE304678 Hs 119598 πbosomal protein L3 62
453355 AW295374 Hs 31412 Homo sapiens cDNA FU11422 fis, clone HE 62
426388 AW081394 Hs 97103 ESTs 62
452502 AI904296 gb PM-BT046-220199-286.1 BT046 Homo sapi 6 1
402546 . 6 1
457534 AI761307 Hs 232226 ESTs 6 1
408165 AL137573 Hs 43143 Homo sapiens mRNA, cDNA DKFZp564A2463 (f 61
404958 61
432501 BE546532 Hs 25682 Homo sapiens mRNA for KIAA1863 protein. 61
442979 AW440782 Hs 174743 ESTs 6 1
422262 AL022315 Hs 113987 lecdn, galactoside-binding, soluble, 2 60
408713 NM 001248 Hs 47042 ectonucleoside tnphosphate diphosphohyd 60
454065 BE394588 gb 601311808F1 NIH.MGC.44 Homo sapiens c 60
430004 U27768 Hs 227571 regulator of G-protem signalling 4 59
401521 59
425087 R62424 Hs 126059 ESTs 59
446298 AF187813 Hs 14637 kidney- and liver-specific gene 59
417761 R13727 Hs 21435 ESTs 59
424806 AA382523 Hs 105689 MSTP031 protein 59
441695 T12411 Hs 183745 hypothetical protein FLJ13456 59
457483 AB034694 Hs 272558 endomucιn-1 59
417175 R44558 Hs 94002 ESTs 58
437483 AL390174 gb Homo sapiens mRNA, cDNA DKFZp547J184 58
436427 AI344378 Hs 143399 ESTs 58
411939 AI365585 Hs 146246 ESTs 58
459053 AI807052 Hs 210361 ESTs 57
411052 AW814950 gb MR1 ST0206-130400-023-dOΘ ST0206 Homo 57
431063 Z98949 Hs 326843 hypothetical protein bk125H2 1 57
450382 AA397658 Hs 60257 Homo sapiens cDNA FU13598 fis, clone PL 57
408478 NM 000806 Hs 45740 gamma-aminobutync acid (GABA) A recepto 57
442676 AI733585 Hs 130897 ESTs 57
446443 AV659082 Hs 134228 ESTs 57
400865 57
459080 AW192083 Hs 290855 ESTs 56
407952 AI215902 Hs 88845 ESTs, Highly similar to T50835 hypothed 56
431984 AL080239 Hs 272284 Human DNA sequence from clone GS1-256022 56
425705 AF007833 Hs 159265 kruppel-related zinc finger protein hcKr 56
442238 AW135374 Hs 270949 ESTs, Moderately similar to F41925 hypot 56
422994 AW891802 Hs 296276 ESTs 56
457148 AF091035 Hs 184627 KIAA0118 protein 56
428356 AL046991 Hs 10338 ESTs 56
415927 AL120168 Hs 78919 Kell blood group precursor (McLeod pheno 55
402092 55
440526 AI832243 Hs 211471 ESTs 55
444409 AI792140 Hs 49265 ESTs 55
417877 AI025829 Hs 86320 ESTs 54
458238 AW071521 Hs 333541 beta-amyloid binding protein precursor 54
430702 U56979 Hs 250651 H factor 1 (complement) 54
456189 H91010 Hs 44940 ESTs 54
427424 AA402453 Hs 113011 ESTs 54
437354 AA749215 Hs 291886 ESTs 54
455617 BE078070 gb CM1-BT0614-160300-149-f02 BT0614 Homo 54
429290 AF203032 Hs 198760 neurofilament heavy polypeptide (200kD) 53
427861 AA813185 Hs 98183 ESTs 53
408556 U49516 Hs 46362 5-hydroxytryptamιne (serotonin) receptor 53
444209 AI753134 Hs 146494 ESTs 53
422831 R02504 Hs 332943 ESTs 53
403180 53
418026 BE379727 Hs 83213 fatty acid binding protein 4, adipocyte 53
430339 W28608 Hs 239625 integral membrane protein 2B 52
431596 T34708 Hs 272927 Sec23 (S cerevisiae) homolog A 52
431930 AB035301 Hs 272211 cadheπn 7, type 2 52
437403 AI208149 Hs 121196 ESTs 52 438285 AA782845 Hs 22790 ESTs 52
439901 N73885 Hs 124169 ESTs 52
438507 AA809052 Hs 211275 ESTs 52
449222 AW293984 Hs 197621 ESTs 52
402834 AK001507 Hs 306084 Homo sapiens clone FLB6914 PR01821 mRNA, 52
419042 T81429 Hs 221065 ESTs 52
436777 AA731199 Hs 293130 ESTs 52
445071 AI280246 Hs 149504 ESTs 51
408016 AW136827 Hs 256096 ESTs 5 1
412047 AA934589 Hs 49696 ESTs 5 1
436953 AW959074 Hs 23648 Homo sapiens cDNA FLJ 13097 fis clone NT 51
436773 AW078629 Hs 82110 PC4 and SFRS1 interacting protein 1 5 1
409263 AA069573 Hs 50319 ESTs 5 1
453830 AA534296 Hs 20953 ESTs 51
459580 AA022888 Hs 176065 ESTs 51
417616 R07728 Hs 268668 ESTs 5 1
423457 F08208 Hs 283844 similar to rat tπcarboxylate carπer-li 5 1
441535 AL135735 Hs 7885 phosphaddylmositol binding clathπn as 50
416490 AF090116 Hs 79348 regulator of G-protem signalling 7 50
417284 N62889 Hs 107242 Homo sapiens cDNA FU12965 fis, clone NT 50
447135 T58148 gb yb98g06 s1 Stratagene lung (937210) H 50
448605 AL109678 Hs 21597 Homo sapiens mRNA full length insert cDN 50
442240 AI791883 Hs 292719 ESTs 49
459399 BE407712 Hs 153998 creatine kinase, mitochondπal 1 (ubiqui 49
427972 AA864870 Hs 181304 putadve gene product 49
432944 AA570687 Hs 38512 ESTs 49
440198 BE560093 gb 601345159F1 NIH MGC 8 Homo sapiens cD 49
444047 AI097452 Hs 135095 ESTs 49
416040 AW819158 Hs 289044 Homo sapiens cDNA FU 12048 fis, clone HE 49
444922 AI921750 Hs 144871 Homo sapiens cDNA FU 13752 fis, clone PL 48
436670 AI690021 Hs 201536 ESTs 48
448072 AI459306 Hs 24908 ESTs 48
408936 AL138043 Hs 293549 ESTs 48
412622 AW664708 Hs 171959 ESTs 48
414943 D80647 Hs 124193 ESTs 48
429254 H10133 Hs 91846 hypothetical protein DKFZp761C121 48
453567 AI742835 Hs 33368 hypothedcal protein FLJ11175 48
407906 AA369665 Hs 41185 Homo sapiens mRNA, cDNA DKFZp56401262 (f 48
441028 AI333660 Hs 17558 Homo sapiens CDNA FU14446 fis clone HE 47
405130 47
455225 AW996689 gb QV3-BN0046-150400-151-g09 BN0046 Homo 47
446218 AV657159 gb AV657159 GLC Homo sapiens cDNA clone 47
443347 AI052543 Hs 133244 melanoma-deπved leucine zipper, extra-n 47
402176 47
416577 BE063207 Hs 79381 grancalcin 47
436221 AK001781 Hs 296543 Homo sapiens cDNA FU10919 fis clone OV 47
420480 AL137361 Hs 98173 hypothedcal protein 47
400800 Y10262 Hs 46925 eyes absent (Drosophila) homolog 3 46
435161 AF124150 Hs 272091 ESTs 46
404793 46
430895 U66581 Hs 248121 G protein-coupled receptor 22 46
438571 AW020775 Hs 56022 ESTs 46
445924 AI264671 Hs 164166 ESTs 46
444585 AW170015 Hs 6594 ESTs 46
421044 AF061871 Hs 311736 Human DNA sequence from clone RP1 238D15 46
418274 AI458587 Hs 128677 Human DNA sequence from clone RP1-50O24 46
425475 W56339 Hs 107057 ESTs 46
434311 BE543469 Hs 266263 Homo sapiens cDNA FLJ14115 fis, clone MA 45
414272 AI651603 Hs 46988 ESTs 45
445235 AI564022 Hs 138207 ESTs 45
414327 BE408145 Hs 185254 ESTs Weakly similar to T24435 hypotheti 45
414630 BE410857 gb 601301177F1 NIH_MGC_21 Homo sapiens c 45
414456 H74314 gb yu56e10 r1 Soares fetal liver spleen 45
401024 45
414699 AI815523 Hs 76930 synuclein, alpha (non A4 component of am 45
423449 AI497900 Hs 33067 ESTs 45
405138 45
413544 BE147225 gb PM2-HT0225J331299003-111 HT0225 Homo 45
453880 AI803166 Hs 28462 ESTs, Weakly similar to I38022 hypothed 45
433521 T66087 Hs 112482 Homo sapiens unknown mRNA sequence 44
441184 AA922009 Hs 150269 ESTs 44
429876 AB028977 Hs 225974 KIAA1054 protein 44
445481 AW661846 Hs 148836 ESTs 44
452340 NM_002202 Hs 505 ISL1 transcnpdon factor, UM/homeodoma 44
404769 44
444331 AW193342 Hs 24144 ESTs 44
429726 AW628326 Hs 27151 ESTs 44
449093 AB035356 Hs 22998 neurexin 1 44
451959 AA056203 Hs 27337 hypothedcal protein FU20623 44
415716 N59294 Hs 179662 nucleosome assembly protein 1-lιke 1 44
417888 R23053 gb yh31a05 r1 Soares placenta Nb2HP Homo 44
419656 AB002314 Hs 92025 KIAA0316 gene product 44
425864 U56420 Hs 159903 olfactory receptor, family 5, subfamily 44 435078 AW518888 Hs 40937 ESTs 44
413493 BE144444 gb MR0-HT0168-141199-002-f09 HT0168 Homo 43
432712 AB016247 Hs 288031 sterol C5-desaturase (fungal ERG3, delta 43
459650 R25754 Hs 301185 ESTs 43
404828 43
423782 AI472209 Hs 323117 ESTs 43
426867 AA460967 Hs 22668 ESTs 43
426802 AA385182 Hs 46699 ESTs 43
457353 X65633 Hs 248144 melanocortiπ 2 receptor (adrenocorticotr 43
412112 BE180342 gb RC3-HT0622-130400-012-a07 HT0622 Homo 43
401522 N47812 Hs 306198 CGI-35 protein 43
419055 AI365384 Hs 11571 Homo sapιens cDNA FU11570 fis, clone HE 43
410171 H07892 Hs 12431 ESTs 43
419564 U08989 Hs 91139 solute earner family 1 (neuronal/epithe 43
458789 AL157468 Hs 325825 Homo sapiens cDNA FU20848 fis, clone AD 43
455040 AW852286 gb QV0-CT0225-1004OO-187-d08 CT0225 Homo 43
438533 AI440266 Hs 170673 ESTs, Weakly similar to T24832 hypothed 43
459005 AA447679 Hs 144558 ESTs, Weakly similar to ALU1.HUMAN ALU S 42
418489 U76421 Hs 85302 adenosine deaminase, RNA-specific, B1 (h 42
433389 AF038171 gb Homo sapiens clone 23671 mRNA sequenc 42
454356 AW390363 Hs 11522 hypothedcal protein from Xq28 42
442339 BE299668 Hs 227591 ESTs, Weakly similar to 1901303A Leu zip 42
421249 AA285362 gb HTH277 HTCDL1 Homo sapiens cDNA 573' 42
443998 AI620661 Hs 296276 ESTs 42
452197 AW023595 Hs 232048 ESTs 42
451117 AA015752 Hs 205173 ESTs 42
404501 AW247252 Hs 75514 nucleoside phosphorylase 42
410378 R23324 Hs 41693 DnaJ (Hsp40) homolog, subfamily B, membe 42
422528 AB011182 Hs 118087 KIAA0610 protein 42
440323 AA970614 Hs 127992 ESTs 41
425767 AF054176 Hs 159483 chromosome 1 open reading frame 7 4 1
434460 AA478486 Hs 3852 KIAA0368 protein 4 1
410362 H04811 Hs 93164 proprotein convertase subtilis /kexin t 4 1
413121 T96090 Hs 1 2678 ESTs 4 1
409403 AA668224 Hs 6634 Homo sapiens cDNA FU22547 fis, clone H 4 1
450235 AA007512 Hs 17538 ESTs 4 1
449754 H00820 Hs 30977 ESTs, Weakly similar to B34087 hypothed 4 1
421813 BE048255 gb tz49b05 y1 NCI CGAP Brn52 Homo sapien 41
408496 AI683802 Hs 136182 ESTs 4 1
430261 AA305127 Hs 237225 hypothetical protein HT023 4 1
434101 AA625205 Hs 259599 KIAA1622 protein 4 1
451837 T92157 Hs 16970 ESTs 4 1
411772 BE170301 gb QV4-HT0536-040500-193-f05 HT0536 Homo 4 1
437630 AI252782 Hs 153026 SWAP-70 protein 4 1
430212 AA469153 gb nc67f04 s1 NCI.CGAP.Pr1 Homo sapiens 40
400216 40
429830 AI537278 Hs 225841 DKFZP434D193 protein 40
453165 S74727 Hs 32042 aspartoacylase (aminoacylase 2, Canavan 40
418047 R37633 Hs 4847 ESTs 40
405354 40
427931 AW206512 Hs 186996 ESTs 40
428775 AA434579 Hs 143691 ESTs 40
449422 AA001373 Hs 59821 ESTs 40
453864 AW021407 Hs 21068 hypothetical protein 40
456407 AW968614 gb EST380690 MAGE resequences, MAGJ Homo 40
441869 NM 003947 Hs 8004 hundngdn-associated protein interacdn 40
420784 T65158 Hs 102399 ESTs, Moderately similar to S65657 alpha 40
425195 AA352026 Hs 94319 VPS10 domain receptor protein 40
429628 H09604 Hs 13268 ESTs 40
410087 F12079 Hs 332579 ESTs 40
409840 AW502122 gb UI-HF-BROp-aιr-c-08-O-UI r1 NIH.MGC.5 40
452854 AA437061 Hs 14060 prokinedcin 1 precursor 40
419910 AA662913 Hs 190173 ESTs, Weakly similar to A46010 X-lmked 40
427443 AA402713 Hs 97872 ESTs 40
414990 C17758 Hs 221652 Homo sapiens cDNA FU14323 fis clone PL 39
412678 AA115575 Hs 114914 ESTs 39
405629 39
420299 AI056871 Hs 15276 ESTs 39
453098 Z25935 Hs 86379 ESTs 39
435752 AF230801 gb Homo sapiens growth hormone receptor 39
441005 Z41305 Hs 303172 Homo sapiens mRNA, cDNA DKFZp547G133 (fr 39
414516 AI307802 Hs 135560 ESTs, Weakly similar to T43458 hypotheti 39
442257 AW503831 Hs 323370 Human EST clone 25267 manner transposon 39
422563 BE299342 Hs 19348 hypothetical protein FU13119 39
406697 M21388 Hs 123017 Human unproducdvely rearranged lg mu-ch 39
443850 AW014723 Hs 334612 ESTs 39
412677 AW029608 Hs 17384 ESTs 39
422788 AL117352 Hs 120828 Human DNA sequence from clone RP5-876B10 39
405377 39
414376 BE393856 Hs 66915 ESTs, Weakly similar to 167Kd protein ( 39
453341 AI758912 Hs 296341 adenylyl cyclase-associated protein 2 39
431960 AW241821 Hs 301927 c6 1A 39
416854 H40164 Hs 80296 Puriunje cell protein 4 39 427264 AA400117 Hs 125747 ESTs 39
422746 NM.004484 Hs 119651 glypican 3 39
452346 BE243534 gb TCBAP1D0885 Pediatπc pre-B cell acut 39
414666 NM_004466 Hs 76828 glypican 5 38
418217 AI910647 Hs 13442 ESTs 38
419118 AA234223 Hs 139204 ESTs 38
445017 AI205493 Hs 176860 ESTs 38
405867 38
422760 BE409561 gb 601299865F1 NIH_MGC_21 Homo sapiens c 38
453863 X02544 Hs 572 orosomucoid 1 38
457821 H47166 Hs 124322 ESTs, Weakly similar to A47582 B-cell gr 38
457330 AB013818 Hs 247220 peroxisome biogenesis factor 10 38
435600 AL047034 Hs 119747 ESTs 38
456083 U46922 Hs 77252 fragile histidine tπad gene 38
413341 H78472 Hs 191325 ESTs Weakly similar to T18967 hypothed 38
449057 AB037784 Hs 22941 KIAA1363 protein 38
421855 F06504 Hs 27384 ESTs, Moderately similar to ALU4 HUMAN A 38
414764 AW013887 Hs 72047 ESTs 38
404391 37
433629 R13140 Hs 13359 ESTs 37
424738 AI963740 Hs 46826 ESTs 37
401315 37
407706 AA191085 Hs 26612 ESTs, Moderately similar to S23650 retro 37
440530 AA888646 Hs 174187 ESTs 37
433930 AA620338 Hs 273781 ESTs 37
409662 AW4S2320 Hs 279726 ESTs 37
437268 AI754847 Hs 227571 regulator of G-proteiπ signalling 4 37
445688 AI248205 Hs 153244 ESTs 37
408593 R19566 Hs 197617 ESTs 37
417091 AA193283 Hs 291990 ESTs 37
448556 AW885606 HS 5064 ESTs 37
423135 N67655 Hs 26411 ESTs 37
400135 37
459150 BE155356 gb PM1-HT0350-160300-009-d06 HT0350 Homo 37
457221 AW383197 Hs 218260 ESTs 37
451660 AI807927 Hs 249601 ESTs 37
401600 BE247275 Hs 151787 U5 snRNP-specific protein, 116 kD 37
446818 AI342668 Hs 279765 ESTs 37
447795 AW295151 Hs 163612 ESTs 37
427562 R56424 Hs 26534 ESTs 36
412258 AA376768 Hs 324841 hypothetical protein FU22622 36
454339 AW381980 gb QV4-HT0316-091199-028-d05 HT0316 Homo 36
439274 AF086092 Hs 48372 ESTs 36
452381 H23329 Hs 290880 ESTs, Weakly similar to ALU1 HUMAN ALU S 36
422897 AA679784 Hs 4290 ESTs 36
429656 X05608 Hs 211584 neurofilament light polypepdde (68kD) 36
421908 AW935200 Hs 285814 sprouty (Drosophila) homolog 4 36
407978 AW385129 Hs 41717 phosphodiesterase 1A, calmodulin-depende 36
426452 AW614271 Hs 121647 ESTs Highly similar to AC0060148 simil 36
400685 36
417154 AI674701 Hs 21388 ESTs 36
447176 Z42549 Hs 160893 ESTs 36
423893 AL031709 Hs 134846 Human DNA sequence from clone 316G12 on 36
449231 BE410360 Hs 298573 KIAA1720 protein 36
411607 AW853498 gb RC1-CT0252-170200-025-h02 CT0252 Homo 36
405977 36
441470 BE503874 Hs 301986 ESTs 36
423568 NM.005256 Hs 129818 growth arrest-specific 2 36
441235 AI884586 Hs 135570 Homo sapiens cDNA FU21268 fis, clone C 36
450236 AW162998 Hs 24684 KIAA1376 protein 36
425364 AF052150 Hs 155959 Homo sapiens clone 24533 mRNA sequence 36
426775 AA384564 Hs 108829 ESTs 36
414831 M31158 Hs 77439 protein kinase, cAMP-dependent, regulato 36
416876 AW501916 Hs 117897 ESTs 36
400878 36
425153 AW023193 Hs 27046 ESTs 36
432222 AI204995 gb an03c03 x1 Stratagene schizo brain S1 35
415047 F13142 gb HSC3JD031 normalized infant brain cDN 35
401532 35
446495 D60923 Hs 153460 ESTs 35
431325 AW026751 Hs 5794 ESTs, Weakly similar to 2109260A B cell 35
445898 AF070623 Hs 13423 Homo sapiens clone 24468 mRNA sequence 35
455901 BE155527 gb PM1-HT0350-190400-013-b08 HT0350 Homo 35
416421 AA134006 Hs 79306 eukaryotic translation initiation factor 35
455697 BE067952 gb CM0-BT0365-061299-122-g09 BT0365 Homo 35
405678 35
418207 C14685 Hs 34772 ESTs 35
425383 D83407 Hs 156007 Down syndrome critical region gene 1-lιk 35
417027 AA192306 Hs 23926 tπadin 35
408367 AK001178 Hs 44424 homolog of rat orphan transporter v7-3 35
417702 R09935 Hs 191146 ESTs 35
445687 W80382 Hs 149297 ESTs 35
408776 AA057365 Hs 63356 ESTs, Weakly similar to I38022 hypothed 35 413164 BE068494 gb MR1-BT0371-050500-009-a12 BT0371 Homo 35
414593 BE386764 gb 601273249F1 NIH_MGC_20 Homo sapiens c 35
453220 AB033089 Hs 32452 Homo sapiens mRNA for KIAA1263 protein, 35
415621 AI648602 Hs 55468 ESTs 35
454437 AI248173 Hs 191460 hypothedcal protein MGC12936 35
446066 AI343931 Hs 149383 ESTs 35
423374 AB037770 Hs 127656 KIAA1349 protein 35
419347 C15944 Hs 90005 supenorcervical ganglia neural specifi 35
418516 NM 006218 Hs 85701 phosphoιnosιdde-3-kιnase, catalytic, al 35
451776 W45679 Hs 169854 hypothedcal protein SP192 35
432305 M62402 Hs 274313 insulin like growth factor binding prote 35
456995 T89832 Hs 170278 ESTs 35
403323 35
425022 M95724 Hs 154207 centromere protein C 1 35
439394 AA149250 Hs 56105 ESTs 34
433803 AI823593 Hs 27688 ESTs 34
450715 AI266484 Hs 31570 ESTs, Weakly similar to KIAA1324 protein 34
411474 AW848427 gb IL3-CT0214-150200-075-H10 CT0214 Homo 34
415076 NM 000857 Hs 77890 guanylate cydase 1 , soluble, beta 3 34
423826 U20325 Hs 1707 cocaine- and amphetamine regulated trans 34
459495 BE544158 gb 601076707F1 NIH MGC 12 Homo sapiens c 34
427173 BE255017 Hs 97540 ESTs 34
408112 AW451982 Hs 248613 ESTs 34
446092 N33522 Hs 145894 ESTs 34
416868 AI656856 Hs 292597 ESTs 34
458234 BE551408 Hs 127196 ESTs 34
419555 AA244416 gb nc07d11 s1 NCI CGAP Pr1 Homo sapiens 34
414314 BE312991 gb 601150275F1 NIH.MGC.19 Homo sapiens c 34
400425 AY004252 Hs 287385 PR domain containing 12 34
414366 BE549143 gb 601076456F1 IH MGC 12 Homo sapiens c 34
434053 AW445136 Hs 134946 ESTs 34
449997 AI683052 Hs 201577 KIAA1829 protein 34
433461 AI636047 Hs 197623 ESTs 34
428006 AA418743 Hs 98306 KIAA1862 protein 34
424695 U58331 Hs 151899 sarcoglycan, delta (35kD dystrophin-asso 34
443294 AI733625 Hs 133053 ESTs 34
428212 AW444451 Hs 134812 ESTs 34
457673 AA551569 Hs 272034 hypothetical protein PR02822 34
446390 AA233393 Hs 14992 hypothedcal protein FLJ11151 33
428536 AI143139 Hs 2288 visinin-like 1 33
426597 AA382250 Hs 145601 ESTs 33
410366 AI267589 Hs 302689 hypothedcal protein 33
458258 AW406546 Hs 127971 ESTs 33
401738 33
409038 T97490 Hs 50002 small inducible cytokine subfamily A (Cy 33
425785 T27017 Hs 159528 Homo sapiens clone 24400 mRNA sequence 33
433328 AW298159 Hs 23644 ESTs, Weakly similar to S65824 reverse t 33
414541 BE293116 Hs 76392 aldehyde dehydrogenase 1 family member 33
434998 AW975157 Hs 26037 ESTs 33
456359 AI967991 Hs 93574 homeo box D3 33
426527 NM 001037 Hs 170238 sodium channel, voltage-gated, type I, b 33
454267 AA437199 Hs 656 cell division cycle 25C 33
400302 N48056 Hs 1915 folate hydrolase (prostate-specific memb 33
434077 AF116659 Hs 321151 Homo sapiens PR01412 mRNA, complete eds 33
436602 AI793222 Hs 166817 ESTs 33
449204 AB000099 Hs 23251 Down syndrome cndcal region gene 4 33
417935 R53697 Hs 170044 ESTs 33
423310 AA325225 Hs 124023 Homo sapiens cDNA FU14218 fis, clone NT 33
436624 T64297 Hs 5241 fatty acid binding protein 1, liver 33
453406 AI192987 Hs 61784 hypothedcal protein FLJ14451 33
420164 AW339037 Hs 24908 ESTs 33
447826 AW779317 Hs 258556 ESTs 33
419875 AA853410 Hs 93557 proenkephalm 33
444612 AW138111 Hs 22902 ESTs 33
418504 BE159718 Hs 85335 Homo sapiens mRNA, cDNA DKFZp564D1462 (f 32
415242 R45986 Hs 295014 ESTs 32
418188 AW139413 Hs 151880 ESTs 32
430355 NM_006219 Hs 239818 phosphoιnosιdde-3-kιnase, catalytic, be 32
421640 AW966652 gb EST378726 MAGE resequences MAGI Homo 32
432359 AA076049 Hs 274415 Homo sapiens cDNA FLJ10229 fis, clone HE 32
408806 AW847814 Hs 289005 Homo sapiens cDNA FU21532 fis, clone C 32
400409 AF153341 Hs 283954 Homo sapiens winged helix forkhead trans 32
446015 T30968 Hs 13531 hypothedcal protein FLJ10971 32
425495 AA358454 Hs 78026 ESTs, Weakly similar to similar to ankyr 32
403092 32
452971 AI873878 Hs 91789 ESTs 32
454186 BE141030 gb MR0-HT0067-2O1099-0O2-M1 HT0067 Homo 32
401485 32
401949 32
457452 AW972675 gb EST384766 MAGE resequences MAGL Homo 32
454100 AI693231 Hs 126043 chromosome 21 open reading frame 51 32
448440 AA173467 Hs 62402 p21/Cdc42/Rac1-actιvated kinase 1 (yeast 32
421200 AA284811 Hs 264433 ESTs 32 430142 NM.000437 Hs 234392 platelet-activating factor acetylhydrola 32
433197 AB040889 Hs 281022 KIAA1456 protein 32
443509 AV645470 gb AV645470 GLC Homo sapiens cDNA clone 32
440827 AI733110 Hs 128128 ESTs 32
432799 NM.016161 Hs 278960 alpha-1,4-N acetylglucosammyltraπsferas 32
409257 AW370362 gb C1-BT0255-181099-012-d07 BT0255 Homo 32
459235 BE246010 Hs 271468 Homo sapiens mRNA for FLJ00038 protein, 32
416789 AA223439 Hs 79933 cyclin 1 32
429809 AL162010 Hs 223603 Homo sapiens mRNA, cDNA DKFZp761D09121 ( 32
420156 AW449258 Hs 6187 ESTs 32
455577 BE006341 gb RC2-BN0127-240300-011-b05 BN0127 Homo 32
400617 AF151064 Hs 36069 hypothedcal protein 32
437129 AL049327 Hs 302057 Homo sapiens mRNA, cDNA DKFZp564E016 (fr 32
451820 AW058357 Hs 337353 ESTs 32
457535 AA609685 Hs 278672 membrane componenL chromosome 11 , surfa 32
419956 AL137939 Hs 40096 ESTs 3 1
456235 AA203637 gb zx58b12 r1 Soares fetal liver spleen 3 1
423930 AA332697 Hs 42721 ESTs 31
403796 31
414085 AA114016 Hs 75746 aldehyde dehydrogenase 1 family, member 3 1
445886 AI793176 Hs 145596 ESTs 3 1
414401 AI760159 Hs 124833 ESTs 31
441573 BE563966 Hs 6529 ESTs, Weakly similar to I78885 senneΛh 3 1
450725 R71389 Hs 175951 ESTs 31
458805 AI282933 Hs 23294 hypothedcal protein FU 14393 31
417868 AI078534 Hs 122592 ESTs 3 1
458391 AI792628 Hs 133273 ESTs 31
423346 AI267677 Hs 127416 synaptoianin 1 31
454486 AW857077 gb RC1-CT0302-140300-016-f04 CT0302 Homo 3 1
408341 AW182952 Hs 249957 ESTs 3 1
410669 AW805749 Hs 318885 superoxide dismutase 2, mitochondπal 3 1
404907 3 1
434910 AI333863 Hs 215474 ESTs, Moderately similar to alternative! 3 1
436990 Al 149729 Hs 120557 ESTs 3 1
441921 AI733376 Hs 164478 hypothedcal protein FU21939 similar to 3 1
454673 AW812807 gb RC3-ST0186-070100-016-C04 ST0186 Homo 3 1
429470 AI878901 Hs 203862 guanine nucleotide binding protein (G pr 3 1
404345 AA730407 Hs 159156 protocadheπn 11 3 1
408217 AI433201 Hs 279860 tumor protein, translationally-controlle 3 1
417313 AA195602 gb zr32f09 r1 Soares.NhHMPu.S1 Homo sapi 3 1
427322 AK002017 Hs 176227 hypothedcal protein FLJ11155 3 1
411003 AA181018 Hs 13056 hypothedcal protein FLJ13920 31
425339 AA936330 Hs 198113 ESTs 3 1
426716 NM 006379 Hs 171921 sema domain, immunoglobulin domain (lg), 3 1
449078 AK001256 Hs 22975 KIAA1576 protein 3 1
429608 U49250 Hs 210862 T-box, brain, 1 3 1
442308 AA989402 Hs 111 fibroblast growth factor 9 (glia-acdvat 3 1
428465 AW970976 Hs 293653 ESTs 3 1
411666 AF106564 Hs 71346 neurofilament 3 (150kD medium) 3 1
447965 AW292577 Hs 94445 ESTs 3 1
413918 AW015898 Hs 71245 ESTs 3 1
419682 H13139 Hs 92282 paired-like homeodomain transcπption fa 3 1
425810 AI923627 Hs 31903 ESTs 3 1
427865 AA416931 Hs 126065 ESTs 3 1
429060 AW139155 Hs 194995 hypothedcal protein DKFZp434O0320 3 1
430708 U78308 Hs 278485 olfactory receptor, family 1, subfamily 3 1
448084 AI467800 Hs 271000 ESTs, Weakly similar to I38022 hypothed 31
454506 AW847346 gb RCO-CT0205-240999-021-e01 CT0205 Homo 31
414629 AA345824 Hs 76688 carboxylesterase 1 (monocyte/macrophage 30
422963 M79141 Hs 13234 ESTs 30
417696 BE241624 Hs 82401 CD69 andgen (p60, eariy T-cell acdvad 30
448175 BE296174 Hs 225160 hypothetical protein FU13102 30
414686 BE409757 Hs 23189 ESTs, Moderately similar to TBB2 HUMAN T 30
458360 AI027207 Hs 132253 ESTs 30
451829 AW964081 Hs 247377 ESTs 30
445179 AI949743 Hs 224768 ESTs 30
433090 AI720050 Hs 145362 immortalization-upregulated protem 30
432018 AA524447 Hs 152377 ESTs 30
407988 N47760 Hs 285107 hypothetical prote FU 13397 30
405911 30
418808 AI821836 Hs 10359 ESTs 30
431900 AW972048 Hs 192534 ESTs 30
452893 H18017 Hs 22869 ESTs, Moderately similar to KIAA1395 pro 30
423952 AW877787 Hs 136102 KIAA0853 protein 30
412000 AW576555 Hs 15780 ATP-bindmg cassette sub-family A (ABC1 30
405793 30
410711 AB0O2316 Hs 65746 KIAA0318 protein 30
411279 AW884776 gb QV4-OT0067-010300-121-d01 OT0067 Homo 30
423957 AW978309 Hs 136235 Homo sapiens cDNA FLJ13542 fis, clone PL 30
427071 AA397958 Hs 192719 ESTs 30
434961 AW974956 gb EST387061 MAGE resequences. MAGN Homo 30
TABLE 10B Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
409257 11129941 AW370362AW809101
409840 1156071 1 AW502122 AW502125 AW501663 AW501720
411052 12303741 AW814950 R98513 H69459 BE176242 H54583
411279 12375161 AW884776 AW935737 AW835261 AW835247 AW835246 AW835263 AW835240 AW835258
411474 12470472 AW848427 AW848890 AW848159 AW848118 AW848634 AW848285 AW848086 AW848485 AW848283 AW848162
411607 1251251 1 AW853498 AW853442 AW853590 AW853433 AW853592
411772 12573861 BE170301 AW861539 AW904851 BE154336 BE154090 BE154275
412112 12778831 BE180342 BE180347 AW901900 BE180222 BE180218 BE180226 BE180413 BE180416 AW901899 BE180228 AW901897 BE180224 AW901898
BE180223 BE180219 BE180346 BE180343 BE180418 BE180225 BE180221 BE180341 AW901894 BE180217 BE180227 AW901891 BE180345
AW893614 AW893615 H85799 H83501 BE180220
413164 1351422.1 BE068494 BE068414 BE068332 BE068347 BE068706 BE068623 BE068450 BE068480 BE068350 BE068295 BE068498 BE068765 BE068328
BE068778 BE068671 BE068526 BE068493 BE068433 BE068740 BE068306 BE068631 BE068580 BE068445 BE068567 BE068521 BE068549
BE068392 BE068307 BE068692 BE068473 BE068754 BE068476 BE068685 BE068626 BE068591 BE068745 BE0684348E068759 BE068628
BE068723 BE068529 BE068689 BE068383 BE068422 BE068470 BE068522 BE068618 BE068354 BE068748 BE068683 BE068303 BE068602
BE068739 BE068374 BE068302 BE068625 BE068596 BE068663 BE068429 BE068605 BE068693 BE068672 BE068401 BE068579 BE068329
BE068390 BE068419 BE068393 BE068447 BE068675 BE068311 BE068540 BE068301 BE068543 BE068719 BE068369 BE068324 BE068588
BE068568 BE068317 BE068384 BE068547 BE068674 BE068436 BE068321 BE068361 BE068676 BE068499 BE068299 BE068352 BE068410
BE068293 BE068418 BE068552 BE068598 BE068327 BE068550 BE068712 BE068661 BE068733 BE068525 BE068752 BE068357 BE068330
BE068565 BE068538 BE068340 BE068537 BE068761 BE068632 BE068758
413493 1373555 1 BE144444 BE144430 413510 1374377.1 F13044 T77009 BE145525 BE145493 413544 1375671.1 BE147225 BE147205 BE147234 414220 1426940 1 BE298094 BE267860 414314 1435028.1 BE312991 BE272945 414366 1438636.1 BE549143 BE390613 BE277344 414456 1447655.1 H74314 BE299593 414593 1464909.1 BE386764 BE387560 414630 1468083.1 BE410857 BE390605 415047 1517450.1 F13142 Z42926 F06135 F06147 H08517 D51360 T75341 417313 166644.1 AA195602 W01148 N40632 417888 1706092.1 R23053 R79884 R76271 419555 185884 1 AA244416 AA244401 421249 200649.1 AA285362 AW752386 AW847156 AA285373 AW879575 AW879558 421640 204833.1 AW966652 AW966653 AA294989 AA385977 421813 207654.1 BE048255 AA313083 AA298419 422760 221034.1 BE409561 BE162756AW732798 425526 252776.1 AA359933 AA358889 AW955306 AW962995 AW837746 AW837755 AW837697 430212 314437.1 AA469153 AI718503 AA469225 432222 343347.1 AI204995 AW827539 A 969908 AW440776 AA528756 433389 36497.1 AF038171 Z43209 F07347 434961 396357.1 AW974956 AA781075 AA654944 435752 41050.1 AF230801 AF230800AA401795 AA398260 437483 43756.1 AL390174 AW898817 440198 48824.-2 BE560093 443509 57199.1 AV645470 T84636 T82805 446052 65988.1 AA358760 AA158850 AW062737 AW062738 AV656291 446218 66686.1 AV657159 BE145509 BE145512 BE145505 BE145507 447135 70963.1 T58148 AW516579 AW059603 452346 912206.1 BE243534 BE243752 AI880228 L44326 452502 919733.1 AI904296 BE007223 R30687 454065 998401.1 BE394588 AW024754 BE183166 BE183167 454186 1049791 1 BE141030 BE141474 BE141467 BE141753 BE141024 BE141761 AW177583 AW177579 AW177582 AW177585 AW177587 AW807582 AW177581
BE141477 BE141520 BE141456 BE141492 BE141028 BE141775 BE141489 BE141751 AW177599 BE141750 AW177597 BE141512 BE141460
BE141749 AW177598
454339 1122972.1 AW381980 BE152244 BE152235 BE152238 BE152232 454486 1215703.1 AW857077 AW861268 AW847383 AW795787 454506 1219857 1 AW847346 AW847395 AW847408 AW847385 AW847342 AW847396 AW847339 AW801718 AW801787 454673 1228669.1 AW812807 AW812815 AW812802 455040 1250028.1 AW852286 AW851934 AW852096 AW852274 455225 1262318 1 AW996689 AW996380 AW996453 BE085650 AW868687 BE085595 455577 1333898 1 BE006341 BE006307 BE006311 455617 1346117.1 BE078070 BE061030 BE077927 455697 1351148 1 BE067952 BE067945 BE067942 BE067943 BE067949 BE067954 BE067944 BE067953 BE067956 BE067946 455901 1381569.1 BE155527 BE155503 BE155188 BE155126 456235 168686 1 AA203637 AA832266 H67452 456407 184986 1 AW968614 AA243209 AA281411 457452 339381 1 AW972675 AA541366 AA523039 459150 919196.1 BE155356 BE153488 BE153461 BE155059 BE155210 BE155413 BE153577 BE153688 BE155063 BE155347 AI903640 BE155492
TABLE 10C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham, et al " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted Nt_posιdon Indicates nucleodde posidons of predicted exons
Pkey Ref Strand Nt_posιdon 400661 8118474 Plus 84912-85187 400685 8118768 Minus 72969-73050,73713-73800
400865 1945037 Minus 44482-45526
400878 9864757 Plus 31493-32842
401024 8117489 Plus 60551-60802
401315 9212516 Minus 198960-199619
401485 7341723 Plus 68009-68209,68841-69077
401521 7705251 Plus 9127-9234
401532 7798785 Plus 124414-124950,125050-125418
401738 2982169 Minus 41547-41757
401780 7249190 Minus 28397-28617,28920-2904529135-29296,29411-29567,29705-29787,30224-30573
401836 7534063 Plus 71981-72084
401949 3492889 Plus 160728-161660
402092 7249154 Minus 107533-108094
402176 7543687 Minus 10-750
402546 7637348 Plus 24673-25170
403092 8954241 Plus 174720-175016,175104-175406,175508-175813
403180 7523976 Minus 63603-63759
403323 8348082 Minus 120366-120845
403796 8099896 Minus 75073-77664
404391 3135305 Minus 26030-26173,27852-27997
404769 8099713 Minus 175801-176823
404793 7232206 Minus 61087-61590
404828 6580415 Minus 26291-27253
404907 7331453 Minus 102880-103828
404958 7407941 Minus 2731-4531
405071 7708797 Minus 11115-11552
405130 8516045 Plus 150235-150449
405138 8576241 Plus 90303-90516
405354 2642452 Plus 52213-53089
405377 5649375 Plus 216656-216848
405629 4508116 Minus 101678-101866
405678 4079670 Plus 151821-152027
405793 1405887 Minus 89197-89453
405800 2791346 Plus 19271-19813
405867 6758731 Minus 74553-75173
405911 6758795 Plus 101008-101643
405977 8247789 Minus 135548-136177
TABLE 11 A ABOUT 533 CNS-ENRICHED GENES SIGNIFICANTLY DOWN-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS TISSUES
Table 11 A lists about 533 CNS-eππched genes significantly down-regulated in glioblastoma compared to normal adult CNS dssues These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the ratio of "average" noππal CNS to "average" glioblastoma was greater than or equal lo 2 The "average" normal CNS level was set to the 75th percendle amongst vanous normal CNS tissues The "average" glioblastoma level was set to the 85th percendle amongst vanous tumor samples To enπch for CNS specific genes, the ratio of "average" CNS to "average" non-CNS normal adult tissues was calculated to be greater than or equal to 2 The "average" CNS level was set to the 85th percendle amongst vnous CNS tissues The "average" normal non-CNS adult dssue level was set to the 85th percendle amongst various non CNS normal dssues In order to remove gene specific background levels of non-specific hybridization, the 10th percendle value amongst vanous non-malignant dssues was subtracted from both the numerator and the denominator before the rados were evaluated
Pkey Unique Eos probeset identifier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Tide Unigene gene dtle
R1 Ratio of 75th percen le normal centra) nervous system dssue to 85th pi
R2 Ratio of 85th percendle central nervous system tissue to 85th percendk
Pkey ExAccn UnigenelD Unigene Title R1 R2
417275 X63578 Hs 295449 parv albumin 290 300
430829 AW451999 Hs 194024 ESTs 25 7 62
410657 AF063228 Hs 65248 dynein, cytoplasmic, intermediate polype 226 258
419954 014720 Hs 93883 myelin protein zero (Charcot-Mane-Tooth 21 2 303
416133 NM 001683 HS 89512 ATPase, Ca« transporting plasma membra 155 168
416018 AW138239 Hs 78977 proprotem convertase subdlism/kexin t 152 180
417167 AW206437 Hs 4290 ESTs 148 17 7
433940 H05129 Hs 7459 cyclic AMP-regulated phosphoprotein, 21 134 18 1
413324 V00571 Hs 75294 corticotropin releasing hormone 13 1 180
439830 AA846666 Hs 151489 ESTs, Weakly similar to XE7.HUMAN PROTEI 126 165
408068 AW148652 Hs 167398 ESTs 126 169
429096 AB011106 Hs 196012 KIAA0534 protein 122 21 1
412638 AA910199 Hs 203838 ESTs 122 160
442593 R39804 Hs 31961 ESTs 108 150
446353 AI290919 Hs 153661 ESTs 104 132
426365 AA376667 Hs 10283 RNA binding motif protein 8B 100 59
414937 R38698 Hs 12382 ESTs 100 108
419643 F06066 Hs 91791 chromosome 11 open reading frame 25 95 109
412454 R55745 Hs 167330 ESTs 95 14 1
439366 AF100143 Hs 6540 fibroblast growth factor 13 94 123
441790 AW294909 Hs 132208 ESTs 92 32
448117 H49129 Hs 172982 ESTs 9 1 128
433558 AA833757 Hs 201769 ESTs, Weakly similar to T24435 hypothed 90 14 7
412453 R20205 Hs 167330 ESTs 90 137
408920 AL120071 Hs 48998 fibronectin leucine nch transmembrane p 89 173
409031 AA376836 Hs 76728 ESTs 87 86
446544 AI631932 Hs 7047 ESTs, Weakly similar to Unknown [H sapie 82 200
439480 AL038511 Hs 125316 ESTs, Weakly similar to S33990 finger pr 82 83 410200 AA082557 Hs 101915 Stargardt disease 3 (autosomal dominant) 80 89
408428 NM.014787 Hs 44896 DnaJ (Hsp40) homolog subfamily B, membe 79 96
437073 AI885608 Hs 94122 ESTs 79 113
408434 AW195317 Hs 107716 hypothetical protein FU22344 79 164
440209 H05049 Hs 22269 neurexin 3 78 343
408119 W26213 Hs 101672 ESTs, Weakly similar to T00331 hypothed 78 90
429611 AI889077 Hs 211388 Homo sapiens BAC clone CTB-60N22 from 7q 77 50
423440 R25234 Hs 143434 contaclin 1 77 9S
445148 AI214510 Hs 146304 ESTs 76 91
416294 D86980 Hs 79170 KIAA0227 protein 76 76
424087 N69333 Hs 143434 contacdn 1 76 103
437479 R61866 Hs 101277 ESTs 75 93
430573 AA744550 Hs 136345 ESTs 71 28
448958 AB020651 Hs 22653 KIAA0844 protein 71 104
419474 AW968619 Hs 155849 ESTs 71 30
423605 AF047826 Hs 129887 cadheπn 19, type 2 70 69
433098 AW190593 Hs 151143 ESTs 70 92
449511 AI436187 Hs 296261 guanine nucleotide binding protein (G pr 69 31
428414 AL049980 Hs 184216 DKFZP564C152 protein 68 50
443155 R54485 Hs 23772 ESTs 68 35
450561 R49674 Hs 25909 ESTs 68 81
433068 NM 006456 Hs 288215 sialyltransferase 68 20
423589 AA328082 Hs 209569 ESTs 66 105
415681 AI379882 Hs 72630 ESTs 65 90
413510 F13044 gb HSC3HH101 normalized infant brain cDN 64 71
427992 Y15014 Hs 181353 UDP-Gal betaGlcNAc beta 1,3-galac.osyltr 64 95
450642 R39773 Hs 7130 copine IV 64 57
429322 D86984 Hs 199243 KIAA0231 protein 64 82
447482 AB033059 Hs 18705 KIAA1233 protein 64 23
446129 AW244073 Hs 145946 ESTs 63 83
421913 AI934365 Hs 109439 osteoglycin (osteoiπductive factor, mime 63 21
434273 AA913143 Hs 26303 ESTs 62 103
408480 AI350337 Hs 164568 fibroblast growth factor 7 (keradnocyte 62 35
451301 AI769514 Hs 209890 EST 62 124
438356 AA805530 Hs 48527 ESTs 62 81
426388 AW081394 Hs 97103 ESTs 62 86
452502 AI904296 gb PM-BT046-220199-286.1 BT046 Homo sapi 61 28
408165 AL137573 Hs 43143 Homo sapiens mRNA, cDNA DKFZp564A2463 (f 61 63
442979 AW440782 Hs 1 4743 ESTs 61 63
408713 NM 001248 Hs 47042 ectonucleoside tπphosphate diphosphohyd 60 38
430004 U27768 Hs 227571 regulator of G-protem signalling 4 59 214
425087 R62424 Hs 126059 ESTs 59 81
441695 T12411 Hs 183745 hypothetical protein FLJ13456 59 31
417175 R44558 Hs 94002 ESTs 58 125
437483 AL390174 gb Homo sapiens mRNA, cDNA DKFZp547J184 58 22
436427 AI344378 Hs 143399 ESTs 58 138
450382 AA397658 Hs 60257 Homo sapiens cDNA FLJ13598 fis, clone PL 57 44
408478 NM 000806 Hs 45740 gamma-aminobutync acid (GABA) A recepto 57 125
442676 AI733585 Hs 130897 ESTs 57 68
446443 AV659082 Hs 134228 ESTs 57 64
459080 AW192083 Hs 290855 ESTs 56 156
431984 AL080239 Hs 272284 Human DNA sequence from clone GS 1-256022 56 82
428356 AL046991 Hs 10338 ESTs 56 62
417877 AI025829 Hs 86320 ESTs 54 49
429290 AF203032 Hs 198760 neurofilament, heavy polypeptide (200kD) 53 131
408556 U49516 Hs 46362 5-hydroxytryptamιne (serotonin) receptor 53 66
431930 AB035301 Hs 272211 cadheπn 7, type 2 52 60
438285 AA782845 Hs 22790 ESTs 52 73
439901 N73885 Hs 124169 ESTs 52 27
449222 AW293984 Hs 197621 ESTs 52 81
408016 AW136827 Hs 256096 ESTs 51 25
436953 AW959074 Hs 23648 Homo sapiens cDNA FLJ13097 fis, clone NT 51 30
436773 AW078629 Hs 82110 PC4 and SFRS1 interacting protein 1 51 73
409263 AA069573 Hs 50319 ESTs 51 129
453830 AA534296 Hs 20953 ESTs 51 34
441535 AL135735 Hs 7885 phosphaddylinositol binding clathπn as 50 48
416490 AF090116 Hs 79348 regulator of G-protem signalling 7 50 201
417284 N62889 Hs 107242 Homo sapiens cDNA FLJ12965 fis, clone NT 50 39
448605 AL109678 Hs 21597 Homo sapiens mRNA full length insert cDN 50 61
442240 AI791883 Hs 292719 ESTs 49 67
427972 AA864870 Hs 181304 putative gene product 49 52
416040 AW819158 Hs 289044 Homo sapiens cDNA FU12048 fis clone HE 49 28
444922 AI921750 Hs 144871 Homo sapiens cDNA FLJ13752 fis, clone PL 48 37
408936 AL138043 Hs 293549 ESTs 48 66
414943 D80647 Hs 124193 ESTs 48 31
429254 H10133 Hs 91846 hypothedcal protein DKFZp761C121 48 23
407906 AA369665 Hs 41185 Homo sapiens mRNA, cDNA DKFZp56401262 (f 48 91
416577 BE063207 Hs 79381 grancalcin 47 22
420480 AL137361 Hs 98173 hypothetical protein 47 28
404793 46 22
430895 U66581 Hs 248121 G protein-coupled receptor 22 46 74
438571 AW020775 Hs 56022 ESTs 46 54
444585 AW170015 Hs 6594 ESTs 46 60 414272 AI651603 Hs 46988 ESTs 4 5 22
414699 AI815523 Hs 76930 synuclein, alpha (non A4 component of am 4 5 309
423449 AI497900 Hs 33067 ESTs 4 5 208
433521 T66087 Hs 112482 Homo sapiens unknown mRNA sequence 44 20
429876 AB028977 Hs 225974 KIAA1054 protein 44 192
429726 AW628326 Hs 27151 ESTs 44 102
449093 AB035356 Hs 22998 neurexin 1 44 94
415716 N59294 Hs 179662 nucleosome assembly protein 1-lιke 1 44 15 1
419656 AB002314 Hs 92025 KIAA0316 gene product 44 82
425864 U56420 Hs 159903 olfactory receptor, family 5, subfamily 44 24
435078 AW518888 Hs 40937 ESTs 44 57
432712 AB016247 Hs 288031 sterol-C5-desaturase (fungal ERG3, delta 43 59
426867 AA460967 Hs 22668 ESTs 43 60
412112 BE180342 gb RC3-HT0622-130400-012-a07 HT0622 Homo 43 32
410171 H07892 Hs 12431 ESTs 4 3 53
442339 BE299668 Hs 227591 ESTs, Weakly similar to 1901303A Leu zip 42 50
421249 AA285362 gb HTH277 HTCDL1 Homo sapiens cDNA 5V3' 4 2 35
422528 AB011182 Hs 118087 KIAA0610 protein 42 39
434460 AA478486 Hs 3852 KIAA0368 protein 4 1 83
410362 H04811 Hs 93164 proprotein convertase subddsin/kexin t 4 1 70
449754 H00820 Hs 30977 ESTs, Weakly similar to B34087 hypothed 4 1 39
408496 AI683802 Hs 136182 ESTs 4 1 47
434101 AA625205 Hs 259599 KIAA1622 protein 4 1 63
430212 AA469153 gb nc67f04 s1 NCI.CGAP.Pr1 Homo sapiens 40 25
453165 S74727 Hs 32042 aspartoacylase (aminoacylase 2, Canavan 40 74
456407 AW968614 gb EST380690 MAGE resequences, MAGJ Homo 40 5 1
441869 NM 003947 Hs 8004 hundngbn-associated protein interacdπ 40 323
429628 H09604 Hs 13268 ESTs 40 4 5
410087 F12079 Hs 332579 ESTs 40 69
419910 AA662913 Hs 190173 ESTs, Weakly similar to A46010 X-dnked 40 26
441005 Z41305 Hs 303172 Homo sapiens mRNA, cDNA DKFZp547G133 (fr 39 21 7
412677 AW029608 Hs 17384 ESTs 39 22
453341 AI758912 Hs 296341 adenylyl cyclase-associated protein 2 39 72
416854 H40164 Hs 80296 Purkinje cell protein 4 39 22
414666 NM 004466 Hs 76828 glypican 5 38 62
418217 AI910647 Hs 13442 ESTs 38 32
421855 F06504 Hs 27384 ESTs, Moderately similar to ALU4.HUMAN A 38 2 2
414764 AW013887 Hs 72047 ESTs 38 107
433629 R13140 Hs 13359 ESTs 37 27
424738 AI963740 Hs 46826 ESTs 37 2 1
407706 AA191085 Hs 26612 ESTs, Moderately similar to S23650 retro 37 53
437268 AI754847 Hs 227571 regulator of G-protem signalling 4 37 537
423135 N67655 Hs 26411 ESTs 37 21 7
446818 AI342668 Hs 279765 ESTs 37 26
427562 R56424 Hs 26534 ESTs 3 6 36
439274 AF086092 Hs 48372 ESTs 36 345
452381 H23329 Hs 290880 ESTs, Weakly similar to ALU1.HUMAN ALU S 36 60
422897 AA679784 Hs 4290 ESTs 36 5 1
429656 X05608 Hs 211584 neurofilament, light polypepdde (68kD) 36 246
417154 AI674701 Hs 21388 ESTs 36 58
447176 Z42549 Hs 160893 ESTs 36 64
405977 36 39
423568 NM 005256 Hs 129818 growth arrest-specific 2 36 25
441235 AI884586 Hs 135570 Homo sapiens cDNA FU21268 fis clone C 36 54
426775 AA384564 Hs 108829 ESTs 36 34
414831 M31158 Hs 77439 protein kinase, cAMP-depeπdenL regulato 36 28
425153 AW023193 Hs 27046 ESTs 36 49
446495 D60923 Hs 153460 ESTs 35 98
445898 AF070623 Hs 13423 Homo sapiens clone 24468 mRNA sequence 35 166
416421 AA134006 Hs 79306 eukaryodc translation inidadon factor 35 50
418207 C14685 Hs 34772 ESTs 3 5 160
425383 D83407 Hs 156007 Down syndrome cπdcal region gene 1-lιk 35 6 2
417027 AA192306 Hs 23926 tnadin 35 25
408367 AK001178 Hs 44424 homolog of rat orphan transporter v7-3 3 5 53
408776 AA057365 Hs 63356 ESTs, Weakly similar to I38022 hypotheti 35 55
453220 AB033089 Hs 32452 Homo sapiens mRNA for KIAA1263 protein, 3 5 236
419347 C15944 Hs 90005 supenorceracal ganglia, neural specifi 35 423
433803 AI823593 Hs 27688 ESTs 34 36
450715 AI266484 Hs 31570 ESTs, Weakly similar to KIAA1324 protein 34 4 1
415076 NM 000857 Hs 77890 guanylate cyclase 1, soluble, beta 3 34 98
423826 U20325 Hs 1707 cocaine- and amphetamine-regulated trans 34 47
427173 BE255017 Hs 97540 ESTs 34 24
446092 N33522 Hs 145894 ESTs 34 35
416868 AI656856 Hs 292597 ESTs 34 4 5
458234 BE551408 Hs 127196 ESTs 34 45
434053 AW445136 Hs 134946 ESTs 34 39
428536 AI143139 Hs 2288 visinm-like 1 33 42 3
410366 AI267589 Hs 302689 hypothedcal protein 33 144
425785 T27017 Hs 159528 Homo sapiens clone 24400 mRNA sequence 33 46
434998 AW975157 Hs 26037 ESTs 33 4 7
456359 AI967991 Hs 93574 homeo box D3 3 3 44
426527 NM 001037 Hs 170238 sodium channel, voltage-gated, type I, b 33 5 2
400302 N48056 Hs 1915 folate hydrolase (prostate-specific memb 33 90 419875 AA853410 Hs 93557 proenkephalin 33 36
444612 AW138111 Hs 22902 ESTs 33 30
415242 R45986 Hs 295014 ESTs 32 22
421640 AW966652 gb EST378726 MAGE resequences, MAGI Homo 32 38
408806 AW847814 Hs 289005 Homo sapiens cDNA FU21532 fis, clone C 32 24
446015 T30968 Hs 13531 hypothetical protein FU10971 32 32
425495 AA358454 Hs 78026 ESTs, Weakly similar to similar to ankyr 32 22
403092 32 29
452971 AI873878 Hs 91789 ESTs 32 45
454100 AI693231 Hs 126043 chromosome 21 open reading frame 51 32 27
448440 AA173467 Hs 62402 p21/Cdc42/Rac1-acdvated kinase 1 (yeast 32 28
421200 AA284811 Hs 264433 ESTs 32 27
440827 AI733110 Hs 128128 ESTs 32 2 1
429809 AL162010 Hs 223603 Homo sapiens mRNA, cDNA DKFZp761D09121 ( 32 43
420156 AW449258 Hs 6187 ESTs 32 19 0
457535 AA609685 Hs 278672 membrane componenL chromosome 11 , surfa 32 20
419956 AL137939 Hs 40096 ESTs 3 1 87
423930 AA332697 Hs 42721 ESTs 3 1 27
417868 AI078534 Hs 122592 ESTs 31 126
423346 AI267677 Hs 127416 syπaptojaπin 1 31 120
441921 AI733376 Hs 164478 hypothedcal protein FU21939 similar to 3 1 43
429470 AI878901 Hs 203862 guanine nucleodde binding protein (G pr 3 1 53
408217 AI433201 Hs 279860 tumor protein, transladonally-controlle 31 7 1
427322 AK002017 Hs 176227 hypothedcal protein FU11155 3 1 63
449078 AK001256 Hs 22975 KIAA1576 protein 3 1 30 1
429608 U49250 Hs 210862 T-box, brain, 1 3 1 22
442308 AA989402 Hs 111 fibroblast growth factor 9 (glia-acdvat 3 1 30
411666 AF106564 Hs 71346 neurofilament 3 (150k0 medium) 31 109
427865 AA416931 Hs 126065 ESTs 3 1 75
430708 U78308 Hs 278485 olfactory receptor, family 1, subfamily 3 1 34
451829 AW964081 Hs 247377 ESTs 30 62
405911 30 24
418808 AI821836 Hs 10359 ESTs 30 62
452893 H18017 Hs 22869 ESTs, Moderately similar to KIAA1395 pro 30 5 1
423952 AW877787 Hs 136102 KIAA0853 protein 30 2 1
412000 AW576555 Hs 15780 ATP-binding cassette sub-family A (ABC1 30 2 1
405793 30 27
410711 A8002316 Hs 65746 KIAA0318 protein 30 14 3
427071 AA397958 Hs 192719 ESTs 30 2 1
453534 NM 014796 Hs 33187 KIAA0748 gene product 30 14 5
413903 AA496493 Hs 23136 ESTs 30 22
426866 U02330 Hs 172816 neuregulm 1 30 11 3
434945 AB033065 Hs 4280 KIAA1239 protein 30 35
412639 AW961284 Hs 296235 ESTs 29 49
453590 AF150278 Hs 33578 KIAA0820 protein 29 33 1
414502 AL133721 Hs 224680 ESTs 29 23
434367 AB020700 Hs 3830 KIAA0893 protein 29 23 1
425121 AI797511 Hs 154679 synaptotagmin I 29 8 1
412494 AL133900 Hs 792 ADP-nbosyladon factor domain protein 1 29 208
401213 29 32
401028 AW673312 Hs 50848 hypothedcal protein FLJ20331 29 34
415191 AA190381 Hs 120810 ESTs 29 30
449275 AW450848 Hs 205457 peπaxin 29 56
419863 AW952691 Hs 93485 Homo sapiens mRNA cDNA DKFZp761D191 (fr 29 350
411421 BE272110 Hs 21177 ESTs 29 20
430865 AI073424 Hs 5232 HSPC125 protein 29 11 4
437486 AW952089 Hs 5636 RAB6A, member RAS oncogene family 29 22
442357 AI458586 Hs 135706 ESTs 29 60
408274 R17315 gb yg12g11 r1 Soares infant brain 1NIB H 29 22
444185 AW298350 Hs 66020 ESTs 28 50
420173 AA256151 Hs 22999 ESTs 28 5 1
428358 AA993222 Hs 101915 Stargardt disease 3 (autosomal dominant) 28 70
447252 R90916 Hs 12449 Homo sapiens transmembrane protein HTMP1 28 44
440260 AI972867 Hs 7130 copine IV 28 106
417084 H08370 Hs 33067 ESTs 28 84
438257 AW474419 Hs 224794 ESTs 28 28
441934 T23939 Hs 7344 ESTs 28 62
447885 F11528 Hs 303172 Homo sapiens mRNA, cDNA DKFZp547G133 (fr 28 35
423552 AF107028 Hs 129783 sodium channel, voltage-gated, type II, 28 34
450940 AI744943 Hs 143209 ESTs, Weakly similar to I38022 hypotheti 28 14 4
410011 AB020641 Hs 57856 PFTAIRE protein kinase 1 28 21 7
445887 AI263105 Hs 145597 ESTs 28 5 1
425494 N55540 Hs 78026 ESTs Weakly similar to similar to ankyr 28 24
438202 AW169287 Hs 22588 ESTs 28 11 9
436199 R38946 Hs 127951 hypothetical protein FLJ14503 28 60
434826 AF155661 Hs 22265 pyruvate dehydrogenase phosphatase 28 24
415462 R52692 Hs 12698 ESTs 28 34
418070 NM 000844 Hs 83407 glutamate receptor, metabotropic 7 28 45
432149 AW614326 Hs 157022 ESTs Weakly similar to T34549 probable 28 95
430371 D87466 Hs 240112 KIAA0276 protein 28 70
437357 AL359559 Hs 331666 Homo sapiens mRNA, cDNA DKFZp76202215 (f 27 25
415838 R44336 Hs 7093 ESTs 27 36
438675 AA813725 Hs 213568 ESTs 27 25 419558 AW953679 gb EST365749 MAGE resequences. MAGC Homo 27 3 1
446318 AI949389 Hs 18067 ESTs 27 41
445183 AB007877 Hs 12385 KIAA0417 gene product 27 53
457012 R41480 Hs 127630 ESTs 27 190
431988 AC002302 Hs 77202 protein kinase C, beta 1 27 72
430223 NM.002514 Hs 235935 nephroblastoma overexpressed gene 27 28
447932 AA837474 Hs 20021 vesicle-associated membrane protein 1 (s 27 38
450214 BE439763 Hs 227571 regulator of G-protem signalling 4 27 69
434731 AA648049 Hs 121518 ESTs 27 50
428839 AI767756 Hs 82302 Homo sapiens cDNA FU14814 (is, clone NT 27 52
407709 AA456135 Hs 23023 ESTs 27 25
422420 U03398 Hs 1524 tumor necrosis factor (ligand) superfami 27 33
443305 AI050693 Hs 133318 ESTs 27 59
435648 H24347 Hs 27524 ESTs 27 150
418407 AL044818 Hs 84928 nuclear transcnpdon factor Y, beta 27 27
436771 AW975687 Hs 292979 ESTs 27 60
428689 NM 014351 Hs 189810 suffortranferase family 4A, member 1 27 48
440503 NM 006539 Hs 7235 calcium channel, voltage-dependent, gamm 27 44
441006 AW605267 Hs 7627 CGI-60 protein 27 3 1
410330 AW023630 Hs 46786 ESTs 26 295
434398 AA121098 Hs 3838 serum-inducible kinase 26 26
438831 BE263273 Hs 6439 synapsm II 26 78
419066 Z98492 Hs 6975 PRO1073 protein 26 34
412643 AW971239 Hs 293982 ESTs 26 22
430456 AA314998 Hs 241503 hypothedcal protein 26 179
416498 U33632 Hs 79351 potassium channel, subfamily K, member 1 26 29
401421 26 20
419530 X98330 Hs 90821 ryanodine receptor 2 (cardiac) 26 42
441817 AW969706 Hs 293332 ESTs 26 38
439203 AA448930 Hs 8453 KIAA1587 protein 26 42
426054 U12431 Hs 166109 ELAV (embryonic lethal, abnormal vision, 26 5 1
444583 AW994403 Hs 100861 hypothetical protein FU14600 26 37
417919 AI928203 Hs 86379 ESTs 26 30
434293 NM 004445 Hs 3796 EphB6 26 32
431716 D89053 Hs 268012 fatty-acid-Coenzyme A ligase, long-chain 26 64
443037 AW500305 Hs 299166 syntaxin 7 26 22
440736 D56919 Hs 265848 myomegalin 26 7 1
404648 26 30
429995 AA463571 gb zx72e09 r1 Soares_total.fetus_Nb2HF8. 26 35
436508 AW604381 Hs 121121 ESTs, Weakly similar to S00755 pleckstπ 26 39
441190 H09073 Hs 25046 ESTs 26 31
432278 AL137506 Hs 274256 hypothetical protein FLJ23563 26 29
442731 AI868167 Hs 131044 ESTs 26 4 1
416836 D54745 Hs 80247 cholecystokin 26 14 9
449071 NM.005872 Hs 22960 breast carcinoma amplified sequence 2 25 24
436321 AA709133 Hs 180144 ESTs 25 28
439693 AI741816 Hs 125897 ESTs 25 36
443212 AW269515 Hs 102500 hypothedcal protein FU20481 25 28
423981 AL122104 Hs 136664 Homo sapiens mRNA cDNA DKFZp434A1627 (f 25 38
407868 NM 000950 Hs 40637 proline-πch Gla (G-carboxyglutamic acid 25 3 1
443992 AW022228 Hs 322922 ESTs 25 27 9
444124 R43097 Hs 6818 ESTs 25 53
411379 AI816344 Hs 12554 ESTs, Weakly similar to NPL4.HUMAN NUCLE 25 380
440474 AI207936 Hs 7195 gamma-aminobutync acid (GABA) A recepto 25 38
446277 AI284218 Hs 159204 ESTs 25 22
410111 AI620206 Hs 189647 ESTs 25 35
445162 AB011131 Hs 12376 piccolo (presynapdc cytomatnx protein) 25 48
410718 AI920783 Hs 191435 ESTs 25 45
417201 T60432 Hs 269084 ESTs, Moderately similar to AF097994 1 L 25 29
420274 AW968000 Hs 143389 ESTs, Weakly similar to T14318 ubiquitin 25 28
433496 AF064254 Hs 49765 VLCS-H1 protein 25 47
437331 AL353933 Hs 21710 hypothetical protein DKFZp761G0313 25 33
437368 AI471969 Hs 182606 ESTs 25 30
441985 BE047625 Hs 169815 ESTs 25 36
410025 BE220489 Hs 113592 ESTs, Moderately similar to 154374 gene 25 92
414680 AA743331 Hs 272572 hemoglobin alpha 2 25 36
429956 AI374651 Hs 22542 ESTs 25 239
429028 AA443439 Hs 48797 ESTs 25 28
438109 AI076621 Hs 71367 ESTs, Moderately similar to ALU7_HUMAN A 25 3 1
439780 AL109688 (Jb Homo sapiens mRNA full length insert 25 23
440888 N45600 Hs 326880 ESTs 25 39
445246 AI217713 Hs 147586 ESTs 25 26
440152 AB002376 Hs 7006 KIAA0378 protein 24 236
432740 AF061034 Hs 278898 tumor necrosis factor alpha-inducible ce 24 2 1
415122 D60708 Hs 22245 ESTs 24 39
432298 AL118812 Hs 274293 Homo sapiens mRNA cDNA DKFZp761G1111 (f 24 98
437948 AA772920 Hs 303527 ESTs 24 98
421360 AA297012 Hs 103839 erythrocyte membrane protein band 4 1-lι 24 28
427115 AW972853 Hs 112237 ESTs 24 22
452074 BE299035 Hs 27747 G protein-coupled receptor 37 (endothed 24 100
436639 D14838 Hs 111 fibroblast growth factor 9 (glia-acbvat 24 35
434520 AA205273 Hs 177011 hypothedcal protein 24 3 1
411529 AA430348 Hs 317596 Homo sapiens cDNA FLJ 12927 fis, clone NT 24 30 442272 AA988302 Hs 129172 ESTs 24 2 1
422927 AW247388 Hs 301423 calcium binding protein 1 (calbrain) 24 27
444647 H14718 Hs 11506 Human clone 23589 mRNA sequence 24 28
415827 H17462 Hs 23079 ESTs 24 150
451397 AA017432 Hs 84529 ESTs, Weakly similar to Z202.HUMAN ZINC 24 39
445200 AA084460 Hs 12409 somatostadn 24 37
451062 AL110125 Hs 25910 Homo sapiens mRNA, cDNA DKFZp564C1416 (f 24 24
420328 Y19062 Hs 96870 staufen (Drosophila, RNA-biπding protein 24 43
432122 AA526514 gb nι60f02 s1 NCI CGAP Ov2 Homo sapiens 24 43
444125 AI124882 Hs 118121 ESTs 24 35
430538 AB032435 Hs 242821 differendadon-associated Na-dependent 24 108
457519 X69438 Hs 3052 eariy growth response 4 24 24
409371 R51736 Hs 12381 ESTs 24 21
456303 AA224872 Hs 115088 ESTs 24 32
440105 AA694010 Hs 6932 Homo sapiens clone 23809 mRNA sequence 24 234
400979 24 4 1
435296 R49685 Hs 24980 ESTs 24 65
408950 AA707814 Hs 14945 long fatty acyl-CoA synthetase 2 gene 24 185
452032 BE244005 Hs 27610 retinoic acid- and interferon-inducible 24 22
432098 AF252297 Hs 91546 cytochrome P450 rednoid metabolizing pr 24 27
408974 AW015458 Hs 297017 ESTs 24 25
412177 Z23091 Hs 73734 glycoprotein V (platelet) 24 28
413153 N94205 gb za27a08 r1 Soares fetal liver spleen 24 25
417583 AA668782 Hs 191284 ESTs, Weakly similar to ALU1.HUMAN ALU S 24 26
452034 F12234 Hs 75893 ankyπn 3, node of Ranvier (ankyπn G) 23 30
424940 AA985308 Hs 194327 ESTs 23 63
431706 AI816086 Hs 296341 adenylyl cyclase-associated protein 2 23 41
419125 AA642452 Hs 130881 B-cell CLL/lymphoma 11 A (zinc finger pro 23 29
423641 AL137256 Hs 130489 ATPase, ammophospholipid traπsporter-li 23 87
436407 T88803 Hs 271507 ESTs, Weakly similar to TIM_HUMAN PROBAB 23 32
448681 AL109781 Hs 21754 Homo sapiens mRNA full length insert cDN 23 52
415669 NM 005025 Hs 78589 senne (or cysteine) proteinase iπhibito 23 547
410765 AI694972 Hs 66180 nucleosome assembly protein 1-lιke 2 23 9 1
422386 AF105374 Hs 115830 heparan sulfate (glucosamine) 3-O-sulfot 23 50
414828 AA156651 gb zl05h05 r1 Soares.pregnant.uterus.NbH 23 24
445556 AI910241 Hs 12887 acdn-related protein 3-beta 23 85
426968 U07616 Hs 173034 amphiphysin (Stiff-Mann syndrome with br 23 263
444562 AA186715 Hs 336429 RIKEN cDNA 9130422N19 gene 23 25
423420 AI571364 Hs 128382 Homo sapiens mRNA, cDNA DKFZp761l1224 (f 23 76
439450 R51613 Hs 125304 ESTs 23 263
427127 AW802282 Hs 22265 pyruvate dehydrogenase phosphatase 23 22
447179 AW015633 Hs 157299 ESTs 23 38
414711 AI310440 Hs 288735 Homo sapiens cDNA FU13522 fis, clone PL 23 23
433449 AW772282 gb hn71b05x1 NCI_CGAP.Kιd11 Homo sapien 23 38
414320 U13616 Hs 75893 ankyπn 3, node of Ranvier (ankyππ G) 23 25
416778 M16505 Hs 79876 steroid sutfatase (microsomal), arylsulf 23 78
425130 AA448208 Hs 99163 ESTs 23 4 1
456664 AW963354 Hs 334409 metallothionem 1G 23 25
438283 AI458931 Hs 37282 ESTs 23 42
417455 AW007066 Hs 18949 ESTs, Weakly similar to CA2B_HUMAN COLLA 23 30
412100 AW892731 gb CMO-NN0005-100300-279-C02 NN0005 Homo 23 37
448981 AI968719 Hs 195387 ESTs 23 32
416101 R24854 Hs 268806 ESTs 23 65
439731 AI953135 Hs 45140 hypothedcal protein FU14084 23 178
415734 NM 014747 Hs 78748 KIAA0237 gene product 23 40 1
424596 AB020639 Hs 151017 estrogen-related receptor gamma 23 29
420230 AL034344 Hs 284186 forWiead box C1 23 24
451559 AL119980 Hs 20935 hypothedcal protein DKFZp761D221 23 57
404835 23 21
456765 AI497900 Hs 33067 ESTs 23 4 1
455517 AW984068 gb RC0-HN0006-160300-011-e06 HN0006 Homo 23 24
408206 AF041853 Hs 43670 kinesin family member 3A 22 18 5
411770 NM 014278 Hs 71992 heat shock protein (hspl 10 family) 22 39
430105 X70297 Hs 2540 cholinergic receptor, nicodnic, alpha p 22 26
458694 F12832 Hs 13298 ESTs 22 49
415091 AL044872 Hs 77910 3-hydroxy-3-methylglutaryl-Coenzyme A sy 22 44
439642 W81441 Hs 153967 ESTs 22 24
450138 AW152104 Hs 200879 ESTs 22 49
454222 BE144344 Hs 7589 ESTs, Weakly similar to A46010 X-dnked 22 37
405326 22 27
431342 AW971018 Hs 21659 ESTs 22 52
453101 AW952776 Hs 94943 ESTs 22 33
408897 N50204 Hs 283709 popolysacchaπde specific response-7 p 22 28
451398 AI793124 Hs 144479 ESTs 22 46
438208 AL041224 Hs 65379 ESTs 22 104
408449 NM 004408 Hs 166161 dynamm 1 22 6 1
414130 AI670831 Hs 71592 Homo sapiens cDNA FU21893 fis, clone H 22 3 1
445016 U79716 Hs 12246 ree n 22 39
424375 AF070547 Hs 146312 Homo sapiens clone 24820 mRNA sequence 22 23
424645 NM 014682 Hs 151449 KIAA0535 gene product 22 11 7
409729 D51315 Hs 106289 ESTs 22 49
432809 AA565509 Hs 131703 ESTs 22 199
422890 Z43784 Hs 75893 ankyπn 3, node of Ranvier (ankyπn G) 22 104 428532 AF157326 Hs 184786 TBP-interxdng protein 22 65
413074 AI871368 Hs 8417 hypothedcal protein DKFZp761M0423 22 34
414442 AA156238 Hs 32501 ESTs 22 32
452768 AW069459 Hs 61539 ESTs 22 20
450440 AB024334 Hs 25001 tyrosine 3-monooxygeπase/tιyptophan 5-mo 22 32
426281 AK000987 Hs 169111 oxidadon resistance 1 22 23
428411 AW291464 Hs 10338 ESTs 22 23
413787 AI352558 Hs 75544 tyrosine 3-monooxygenaseΛryptophan 5-mo 22 31
451734 NM.006176 Hs 26944 neurogranin (protein kinase C substrate, 22 85
439108 AW163034 Hs 6467 synaptogyπn 3 22 79
405385 22 24
447285 AI371849 Hs 200696 ATPase, Class VI, type 11C 22 22
452667 T87219 Hs 13219 ESTs 22 3 1
422234 AF119818 Hs 113287 discs, large (Drosophila) homotog-associ 2 1 83
410339 AI916499 Hs 298258 ESTs 2 1 32
413231 D87461 Hs 75244 BCL2-lιke 2 2 1 45
447104 R19085 Hs 210706 Homo sapiens cDNA FU13182 fis, clone NT 2 1 22
451952 AL120173 Hs 301663 ESTs 2 1 365
415841 Z45637 Hs 7093 ESTs 2 1 24
441086 AI928489 Hs 213490 ESTs, Weakly similar to N33.HUMAN N33 PR 21 22
450407 NM 000810 Hs 24969 gamma-aminobutync acid (GABA) A recepto 2 1 66
427627 R87582 Hs 179915 guanine nucleotide binding protein (G pr 2 1 53
449712 R56545 Hs 6100 ESTs 21 45
409660 AW452065 Hs 258905 ESTs 2 1 21
430434 AL049548 Hs 241420 Homo sapiens mRNA for KIAA1756 protein, 21 54
434138 AA625804 gb zu86h01 s1 Soares.tesds.NHT Homo sap 2 1 30
448610 NM 006157 Hs 21602 nel (chιcken)-lιke 1 21 48
418948 AI2Ϊ7097 gb d43h07 1 Soares_fetal_heart_NbHH19W 2 1 29
414876 AW950925 Hs 924 ciystall , mu 2 1 34
440426 AI159800 Hs 7181 Homo sapiens cDNA FU13663 fis, clone PL 21 37
451249 AA016227 Hs 27280 ESTs 2 1 41
451475 T19093 Hs 26450 KIAA0725 protein 2 1 2 1
448743 AB032962 Hs 21896 KIAA1136 protein 21 297
430814 U89336 Hs 247993 NG5 protein 2 1 27
426990 AL044315 Hs 173094 Homo sapiens mRNA for KIAA1750 protein, 2 1 23
426642 AW068223 Hs 171581 ubiquitin C-terminal hydrolase UCH37 2 1 45
427335 AA448542 Hs 251677 G andgen 7B 2 1 22
459089 F13036 Hs 27373 Homo sapiens mRNA, cDNA DKFZp56401763 (f 2 1 23
435832 AA425688 Hs 41641 Bruno (Drosophila) -like 4, RNA binding 2 1 59
446383 T05816 Hs 92511 ESTs 21 29
412768 AW996044 Hs 26239 Human DNA sequence from clone RP11-438B2 2 1 2 1
453976 BE463830 Hs 163714 ESTs 2 1 42
415111 R39039 Hs 328455 EST 2 1 33
452238 F01811 Hs 187931 ESTs 2 1 49
445279 R41900 Hs 22245 ESTs 2 1 98
448799 AI937094 Hs 179080 ESTs 2 1 31
418338 NM 002522 Hs 84154 neuronal pentraxm I 2 1 83
445725 AK000956 Hs 13209 hypothetical protein FU10094 2 1 54
443537 D13305 Hs 203 cholecystokinin B receptor 2 1 41
454066 X00356 Hs 37058 calcitoniπ/calciton -related polypepdd 2 1 64
429954 AI918130 Hs 21374 ESTs 2 1 72
415292 H29016 Hs 200576 ESTs 2 1 39
423563 R34734 Hs 75209 protem kinase (cAMP-dependent, catalyd 2 1 3 1
424906 AI566086 Hs 153716 Homo sapiens mRNA for Hmob33 protein, 3' 2 1 47
459309 AA040620 Hs 5672 hypothedcal protein AF140225 2 1 22
439340 AB032436 Hs 6535 brain-specific Na-dependent inorganic ph 2 1 47
402598 BE314624 Hs 3128 polymerase (RNA) II (DNA directed) polyp 21 54
435406 F26698 Hs 884 calcium/calmodulin-dependent protein kin 2 1 66
448792 R42550 Hs 12826 ESTs 2 1 41
449500 AW956345 Hs 12926 ESTs 2 1 24
441134 W29092 Hs 7678 cellular retinoic acid-binding protein 1 21 58
433361 AW469373 Hs 300141 nbosomal protein L39 2 1 27
452946 X95425 Hs 31092 EphA5 2 1 50
426167 AF039023 Hs 167496 RAN binding protein 6 20 22
453666 AW015681 Hs 135229 ESTs, Weakly similar to A2BP_HUMAN ATAXI 20 31
424632 AB014523 Hs 151406 KIAA0623 gene product 20 35
448589 AF017090 Hs 21554 KIAA1107 protein 20 4 1
430416 AC005531 Hs 57806 Homo sapiens PAC clone RP4-701O16 from 7 20 23
445627 AW818475 Hs 7363 ESTs 20 2 1
417092 H97508 Hs 181165 eukaryotic translation elongadon factor 20 25
453653 AW505554 Hs 144559 ESTs 20 47
435850 AF250847 Hs 283514 mitochondnal ceramidase 20 37
435086 AW975243 Hs 122596 ESTs 20 2 1
423191 D61506 Hs 8417 hypothedcal protein DKFZp761M0423 20 21
411562 AL050201 Hs 70769 hypothedcal protein DKFZp586E1923 20 28
431645 AF078849 Hs 266483 dynein light chain-A 20 25
429834 AI929645 Hs 225936 synapsin I 20 36
439607 BE540565 Hs 159460 ESTs 20 175
408033 AW138045 Hs 242256 ESTs 20 40
430317 AB020645 Hs 239189 glutaminase 20 27
419631 AW188117 Hs 303154 popeye protein 3 20 26
432660 AI288430 Hs 64004 ESTs 20 23
454048 H05626 Hs 6921 ESTs 20 159 426917 AA913814 Hs 172854 DKFZP586B0923 protein 20 31
423246 AL119114 Hs 77196 spectnn, alpha, non-erγthrocydc 1 (alp 20 29
415989 AI267700 Hs 317584 ESTs 20 48
420276 AA290938 Hs 190561 ESTs Highly similar to SORL HUMAN SORTI 20 51
424983 AI742434 Hs 169911 ESTs 20 159
446296 AA985662 Hs 63131 Homo sapiens cDNA FLJ13155 fis clone NT 20 27
450006 AI241555 Hs 60171 ESTs 20 35
TABLE 11B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession 408274 104999.1 R17315Z43964AA053547 412100 1277224.1 AW892731 H08502Z45826 412112 1277883 1 BE180342 BE180347 AW901900 BE180222 BE180218 BE180226 BE180413 BE180416 AW901899 BE 180228 AW901897 BE180224
AW901898 BE180223 BE180219 BE180346 BE180343 BE180418 BE1802258E180221 BE180341 AW901894 BE180217 BE180227 AW901891
BE180345 AW893614 AW893615 H85799 H83501 BE180220
413153 1350849 1 N94205 BE067565 BE067556 413510 1374377 1 F13044 T77009 BE145525 BE145493 414828 149563.Ϊ AA156651 AA156622 R14472 418948 180808.1 AI217097 AW886090 W38035 W38792 AA232835 AW936043 419558 185904 1 AW953679 AW953680 AA244436 H82527 AA361046 AA244483 H82526 421249 200649.1 AA285362 AW752386 AW847156 AA285373 AW879575 AW879558 421640 204833.1 AW966652 AW966653 AA294989 AA385977 429995 311738.1 AA463571 AI277645 AL118763 430212 314437.1 AA469153 AI718503 AA469225 432122 341756.1 AA526514 AW973343 AA554293 433449 366532.1 AW772282 AA592974 434138 380572.1 AA625804 AW418787 AW074833 AI675642 AI393368 437483 43756.1 AL390174AW898817 439780 47673.1 AL109688 R23665 R26578 452502 919733.1 AI904296 BE007223 R30687 455517 1321782.1 AW984068 AW984072 AW984077 456407 184986.1 AW968614AA243209 AA281411
TABLE 11C
Pkey Unique number corresponding to an Eos probeset Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publicadon endtled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495 Strand Indicates DNA strand from which exons were predicted
Ntjosidon Indicates nucleodde posidons of predicted exons Pkey Ref Strand Nt.posidon
400979 8072554 Plus 160842-161028
401213 9858408 Plus 98243-983809848998619
401421 7452889 Minus 142291-142461
403092 8954241 Plus 174720-175016,175104-175406,175508-175813 404648 9796894 Minus 115334-116020
404793 7232206 Minus 61087-61590
404835 6970743 Plus 85462-85684,88139-88287,90338-91018,94827-94990
405326 4375975 Plus 10633-10709,30805-30893,38078-38253,55112-55327,57718-57818,66696-66841
405385 6552772 Plus 48332-48454 405793 1405887 Minus 89197-89453
405911 6758795 Plus 101008-101643
405977 8247789 Minus 135548-136177 TABLE 12A ABOUT 678 GENES UP-REGULATED IN LOWER GRADE GLIOBLASTOMA COMPARED TO NORMAL CENTRAL NERVOUS SYSTEM
Table 12A lists about 678 genes up-regulated in lower grade glioblastoma (LGG) compared to normal central nervous system (CNS) I hese were selected from 59680 probesets on the Atfymetnx/Eos Hu03 GeneChip array such that the ratio of "average" LGG to "average" CNS dssues was greater than or equal to 25 The "average" LGG level was set to the 85" percendle amongst vanous LGG tumors The "average" normal CNS dssue level was set to the 85* percendle amongst vaπous CNS tissues In order to remove gene-specific background levels of non-specific hybndization. the 10" percentile value amongst vanous non-malignant dssues was subtracted from both the numerator and the denominator before the rado was evaluated
Pkey Unique Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dtle Rl Ratio of LOWER GRADE GLIOBLASTOMA to normal CNS
Pkey ExAccn UnigenelD Unigene Tide R1
412420 AL035668 Hs 73853 bone morphogenetic protein 2 203
424800 AL035588 Hs 153203 MyoD family inhibitor 195
453392 U23752 Hs 32964 SRY (sex determining region Y)-box 11 185
402604 Target Exon 169
444190 AI878918 Hs 10526 cysteine and glyc e-nch protein 2 150
409638 AW450420 Hs 21335 ESTs 140
443731 AI083928 Hs 145418 ESTs 140
456759 BE259150 Hs 127792 delta (Drosophιla)-lιke 3 136
447342 AI199268 Hs 19322 Homo sapiens, Similar to RIKEN cDNA 2010 122
433001 AF217513 Hs 279905 clone HQ0310 PRO0310p1 103
427019 AA001732 Hs 173233 hypothedcal protein FU 10970 95 425187 AW014486 Hs 22509 ESTs 90
440210 AW674562 Hs 125296 ESTs 88
448769 N66037 Hs 38173 ESTs 84
437034 AA742643 gb πy91c01 s1 NCI CGAP GCB1 Homo sapiens 82
449539 W80363 Hs 58446 ESTs 8 1
417061 AI675944 Hs 188691 Homo sapiens cDNA FU 12033 fis clone HE 80
435020 AW505076 Hs 301855 DiGeorge syndrome cndcal region gene 8 78
414217 AI309298 Hs 279898 Homo sapiens cDNA FU23165 fis, clone L 77
449300 AI656959 Hs 346514 ESTs 76
449969 AW295142 Hs 180187 Homo sapiens cDNA FLJ 14337 fis, clone PL 75
452372 AI885742 Hs 228474 ESTs 72
410102 AW248508 Hs 279727 ESTs, homologue of PEM 3 (Oona savignyi 72
417308 H60720 Hs 81892 KIAA0101 gene product 72
447004 AW296968 Hs 157539 ESTs 7 1
418113 AI272141 Hs 83484 SRY (sex determining region Y)-box 4 7 1
424635 AA420687 Hs 115455 Homo sapiens cDNA FLJ14259 fis, clone PL 7 1
406478 Target Exon 7 1
428728 NM 016625 Hs 191381 hypothedcal protein 69
414761 AU077228 Hs 77256 enhancer of zeste (Drosophila) homolog 2 69
428037 N47474 Hs 89230 potassium intermediate/small conductance 67
423343 AA324643 Hs 246106 ESTs 67
418097 R45137 Hs 21868 ESTs 67
431553 X78075 Hs 2799 cartilage linking protein 1 66
412326 R07566 Hs 73817 small inducible cytokine A3 (homologous 66
425397 J04088 Hs 156346 topoisomerase (DNA) II alpha (170kD) 64
419169 AW851980 Hs 262346 ESTs, Weakly similar to S72482 hypothed 64
431117 AF003522 Hs 250500 delta (Drosophιla)-lιke 1 64
445908 R13580 Hs 13436 Homo sapiens clone 24425 mRNA sequence 63
402855 NM.001839" Homo sapiens calponin 3, acid 62
424009 F11690 gb HSC30D041 normalized infant brain cDN 62
400419 AF084545 Target 62
446584 U53445 Hs 15432 downregulated in ovanan cancer 1 60
414020 NM 002984 Hs 75703 small inducible cytokine A4 (homologous 60
426140 AF131798 Hs 343768 Homo sapiens clone 25119 mRNA sequence 59
427144 X95097 Hs 2126 vasoacdve intestinal pepdde receptor 2 59
416658 U03272 Hs 79432 fibπldn 2 (congenital contractural ara 58
405238 Target Exon 57
421977 W94197 Hs 110165 πbosomal protein L26 homolog 57
405348 C7001664 gι|12698061|dbj|BAB21849 1| (AB 56
428795 R45503 Hs 97469 ESTs, Highly similar to A39769 N-acetyll 54
422672 X12784 Hs 119129 collagen type IV, alpha 1 53
403349 NM 001406 ephπn-B3 53
453941 U39817 Hs 36820 Bloom syndrome 52
429139 F09092 Hs 66087 ESTs 52
454860 AW835767 gb QV4-LT0016-240200-110-b08 LT0016 Homo 52
452279 AA286844 Hs 61260 hypothetical protein FLJ13164 5 1
418030 BE207573 Hs 83321 neuromedin B 5 1
429469 M64590 Hs 27 glycine dehydrogenase (decarboxyladng, 5 1
450639 AI703186 Hs 277174 ESTs 5 1
412811 H06382 ESTs 51
442832 AW206560 Hs 253569 ESTs 5 1
436608 AA628980 down syndrome cπtical region protein DS 5 1
408161 AW952912 Hs 300383 hypothetical protem MGC3032 5 1
443744 AI084326 Hs 271548 ESTs, Weakly similar to 178885 seπne/th 5 1
447497 AW167254 Hs 205722 ESTs 50
450811 AI739486 Hs 245497 ESTs 50
433244 AB040943 Hs 271285 KIAA1510 protein 49
438458 AW975186 gb EST387294 MAGE resequences, MAGN Homo 49
438456 AA913381 Hs 20594 ESTs 49
411048 AK001742 Hs 67991 hypothedcal protein DKFZp434G0522 49
456304 AI820973 gb nc21c02 y5 NCI.CGAP.Pr1 Homo sapiens 49
442547 AA306997 Hs 217484 ESTs, Weakly similar to ALU 1.HUMAN ALU S 49
419991 AJ000098 Hs 94210 eyes absent (Drosophila) homolog 1 48
402274 C19000498" gι|4567179|gb|AAD23607 1|AC00 48
420092 AA81 043 Hs 88045 ESTs 48
436282 R91913 Hs 272104 ESTs, Moderately similar to ALU1.HUMAN A 48
430809 AI791150 Hs 262009 ESTs Moderately similar to I38022 hypot 48
455104 BE064863 gb RC1-BT0313-110300-015-.06 BT0313 Homo 48
403961 Target Exon 48
424954 NM 000546 Hs 1846 tumor protein p53 (Li-Fraumem syndrome) 48
414825 X06370 Hs 77432 epidermal growth factor receptor (avian 48
447891 R41754 Hs 6496 ESTs 47
423529 T87318 Hs 120411 ESTs 47
422737 M26939 Hs 119571 collagen, type III, alpha 1 (Ehlers-Danl 47
428722 U76456 Hs 190787 dssue inhibitor of metalloproteinase 4 46
437698 R61837 Hs 7990 ESTs, Moderately similar to I84505 calci 46
403481 Target Exon 46
426075 AW513691 Hs 270149 ESTs, Weakly similar to 2109260A B cell 46
422170 AI791949 Hs 112432 and-Mulleπan hormone 46
416379 N38857 Hs 203933 ESTs 46
406481 Target Exon 45
456052 BE311901 Hs 28935 gb 601142614F1 NIH.MGC.14 Homo sapiens c 45
423178 AI033140 Hs 124983 Homo sapiens mRNA, cDNA DKFZp564C142 (fr 45 411642 NM 014932 HS 71132 neuroligin 1 45
428282 N34905 Hs 44653 Homo sapiens cDNA FU22669 fis, clone H 45
432625 AI243596 Hs 94830 ESTs, Moderately similar to T03094 A-kin 45
452994 AW962597 Hs 31305 KIAA1547 protein 45
449961 AW265634 Hs 133100 ESTs 44
401454 NM.014226* Homo sapiens renal tumor and 44
406395 Target Exon 44
432281 AK001239 Hs 274263 hypothetical protein FU10377 44
453792 AL134539 Hs 254129 KIAA1678 44
415131 D61119 gb HUM158C11B Clontech human fetal brain 44
437695 AA769202 Hs 192142 ESTs 44
422081 AW136820 Hs 196011 ESTs 44
437748 AF234882 Hs 5814 suppression of tumoπgemcity 7 43
433323 AA805132 Hs 159142 ESTs 43
420352 BE258835 gb 601117374F1 NIH_MGC_16 Homo sapiens c 43
444218 AF070641 Hs 10684 Homo sapiens clone 24421 mRNA sequence 43
441035 AI694309 Hs 126458 ESTs 43
443836 BE221613 Hs 140553 ESTs 43
425292 NM.005824 Hs 155545 37 kDa leucine-πch repeat (LRR) protein 43
450166 AA429504 ESTs 43
429149 AW193360 Hs 197962 ESTs, Weakly similar to I38022 hypothed 42
422798 R92347 Hs 34574 ESTs, Weakly similar to ALU1 HUMAN ALU S 42
451254 AI571016 Hs 172967 ESTs 42
409189 AA125984 gb zn27h06 r1 Stratagene neuroepithelium 42
445118 AI208762 Hs 345572 ESTs 42
444326 AI939357 Hs 270710 ESTs 42
456060 C14904 Hs 45184 Homo sapiens cDNA FU12284 fis, clone MA 42
404120 C5000537* gι|3298595|gb|AAC41376 1| (AF0 42
436899 AA764852 Hs 291567 ESTs 4 1
407624 AW157431 Hs 248941 ESTs 4 1
453361 AA035197 Hs 107375 ESTs 4 1
447439 AA313565 Hs 145020 ESTs, Weakly similar to KIAA1205 protein 4 1
438372 AI140189 Hs 123191 ESTs 4 1
438624 AA889055 Hs 123468 ESTs 4 1
422493 AW474183 Hs 250173 hypothetical protein FU13158 4 1
406872 AI760903 gb ι09h08 x1 NCI.CGAP CLL1 Homo sapiens 4 1
425295 AA431366 Hs 37251 ESTs 4 1
425849 AJ000512 Hs 296323 serum/glucocorticoid regulated kinase 4 1
434206 AW136973 Hs 180479 ESTs, Weakly similar to S69890 mitogen i 40
420602 AF060877 Hs 99236 regulator of G-protem signalling 20 40
400645 Target Exon 40
456306 AA225313 Hs 222886 ESTs, Weakly similar to TRHY HUMAN TRICH 40
419326 W94915 Hs 42419 ESTs 40
414948 C15240 Hs 182155 ESTs 40
423198 M81933 Hs 1634 cell division cycle 25A 40
411537 BE073250 gb MRO-BT0551-060300-102-eO5 BT0551 Homo 40
421637 AF035290 Hs 106300 Homo sapiens clone 23556 mRNA sequence 39
439231 AW581935 Hs 141480 Homo sapiens mRNA, cDNA DKFZp434N079 (fr 39
429433 AA452899 Hs 213586 ESTs, Weakly similar to KIAA1353 protein 39
424186 AI536021 Hs 288706 Homo sapiens cDNA FLJ10281 fis, clone HE 39
449932 AI675444 Hs 263024 ESTs 39
434072 H70854 Hs 283059 Homo sapiens PRO1082 mRNA, complete eds 39
434784 AA649051 Hs 164007 ESTs 39
425146 AW954627 gb EST366697 MAGE resequences, MAGC Homo 39
428538 AA446440 Hs 98643 ESTs 39
443318 AI051603 Hs 133141 ESTs 39
416857 AA188775 Hs 292453 ESTs 39
411688 AW953440 gb EST365510 MAGE resequences, MAGB Homo 39
447343 AA256641 Hs 236894 ESTs, Highly similar to S02392 alpha-2-m 39
425905 AB032959 Hs 318584 novel C3HC4 type Zinc finger (πng finge 38
403696 C4001100' gι|5852342|gb|AAD54015 1| (AF0 38
415884 H22966 Hs 13471 ESTs 38
432646 AW753310 gb RC3-CT0254-031099-012-C05 CT0254 Homo 38
447057 AI423407 Hs 157697 ESTs 38
400814 Target Exon 38
441329 AI203575 Hs 46821 hypothedcal protein FU20086 38
416664 H72780 Hs 20289 ESTs 38
426044 AA502490 Hs 170290 ESTs 38
455646 BE064420 gb RC4-BT0311-241199-012-c08 BT0311 Homo 38
419043 T19167 Hs 89566 ets variant gene 1 38
445075 AI651827 Hs 344767 ESTs 38
457211 AW972565 Hs 32399 ESTs, Weakly similar to S51797 vasodilat 38
420004 AW975532 Hs 164039 ESTs. Moderately similar to I38022 hypot 38
428060 AA420616 Hs 249483 ESTs 37
416427 BE244050 Hs 79307 Rac/Cdc42 guanine exchange factor (GEF) 37
453038 AW292415 Hs 20509 HBV pX associated proteιn-8 37
404584 Target Exon 37
447143 AW292408 Hs 152290 ESTs, Highly similar to JC2463 vasoacdv 37
453438 AI469935 Hs 22792 ESTs 37
429643 AA455889 Hs 167279 FYVE-finger-contaiπing Rab5 effector pro 37
458072 AI890347 Hs 271923 Homo sapiens cDNA FU22785 fis, clone K 37
459660 M79082 ESTs 37
432188 AI362952 Hs 2928 solute earner family 7 (cadonic ammo 37 430744 AA485229 Hs 105649 ESTs 37
454392 BE260893 Hs 236131 homeodomam-interacdng protein kinase 2 37
454457 AW753456 gb QV2-CT0261-261099-011-d11 CT0261 Homo 37
435095 AA021160 Hs 4750 hypothetical protein DKFZp564K0822 37
438206 AA780385 Hs 187885 ESTs 37
418967 NM 001725 Hs 89535 bactencidal/permeability-increasing pro 37
427809 M26380 Hs 180878 lipoprotein lipase 37
427722 AK000123 Hs 180479 hypothedcal protein FU20116 37
413986 Z43567 gb HSC1FC021 normalized infant brain cDN 37
438898 AI819863 Hs 106243 ESTs 37
418483 W26076 Hs 221847 ESTs 37
415849 R20529 Hs 6806 ESTs 36
438380 T06430 Hs 6194 chondroidn sulfate proteoglycan BEHAB/b 36
440296 D30829 Hs 180610 splicing factor proline/glutamine rich ( 36
438025 AW501360 Hs 258910 ESTs 36
458970 AW246119 Hs 25300 phosphaddydnositol 4-kιnase type II 36
448002 Y15227 Hs 20149 deleted in lymphooytic leukemia, 1 36
432058 AW665996 Hs 130729 ESTs, Weakly similar to ALU1 HUMAN ALU S 36
409557 BE182896 Hs 211193 ESTs 36
418049 AA211467 Hs 190488 Homo sapiens, Similar to nuclear localiz 36
425331 AW962128 gb EST374201 MAGE resequences, MAGG Homo 36
424051 AL110203 Hs 138411 Homo sapiens mRNA, cDNA DKFZp586J1922 (f 36
404185 Target Exon 36
427517 AA644142 Hs 7107 ESTs, Weakly similar to ALU7_HUMAN ALU S 36
421094 AW978202 Hs 289064 hypothetical protein FU22251 36
440388 AI693520 Hs 223000 ESTs 36
415934 NM 000928 Hs 992 phospholipase A2, group IB (pancreas) 36
408292 AW178363 gb RC3-HT0105-010999-002-H06 HT0105 Homo 36
442432 BE093589 Hs 38178 hypothetical protein FU23468 36
451826 AA020741 Hs 171611 ESTs 36
427375 AL035460 Hs 177536 metallocarboxypepddase CPX-1 36
419485 AA489023 Hs 99807 ESTs, Weakly similar to unnamed protein 36
416370 N90470 Hs 203697 ESTs, Weakly similar to I38022 hypothed 36
418400 BE243026 Hs 301989 KIAA0246 protein 36
436674 AA725002 Hs 272018 low molecular mass ubiquinone-binding pr 35
407013 U35637 gb Human nebulin mRNA, partial eds 35
403108 ENSP00000241415" Hypothedcal 677 kDa p 35
422564 AI148006 Hs 222120 ESTs 35
450297 AW901347 Hs 38592 hypothetical protein FU23342 35
436338 W92147 Hs 118394 ESTs 35
447458 AI741082 Hs 158961 ESTs 35
457364 AW971037 gb EST383123 MAGE resequences MAGK Homo 35
458814 AI498957 Hs 170861 ESTs, Weakly similar to Z195 HUMAN ZINC 35
441701 AW339828 Hs 127497 ESTs 35
405558 Target Exon 35
452682 AA456193 Hs 9071 progesterone membrane binding protein 35
434589 AF147363 gb Homo sapiens full length insert cDNA 35
443282 T47764 Hs 132917 ESTs 35
405183 NM.016358* Homo sapiens iroquois homeobo 35
410064 X53416 Hs 195464 filamin A, alpha (actin binding protein- 35
425234 AW152225 Hs 165909 ESTs, Weakly similar to I38022 hypothed 35
404272 Target Exon 35
428808 AA436007 Hs 188780 ESTs 35
447444 AK000318 Hs 18616 hypothetical protein FU20311 35
450475 AW805634 Hs 205015 ESTs 34
454451 AW846706 gb QV3-CT0192-211099-008-g02 CT0192 Homo 34
400379 NM_018432 Homo sapiens ovaπan cancer related prot 34
440948 AW188311 Hs 128619 ESTs 34
449611 AI970394 Hs 197075 ESTs 34
445666 R59960 Hs 282386 ESTs 34
445828 F05802 Hs 81907 ESTs 34
437528 N59646 Hs 169745 crumbs (Drosophila) homolog 1 34
442927 AI024347 Hs 131519 ESTs 34
451130 AI762250 Hs 345554 ESTs 34
454765 AW819629 gb RC5-ST0293-140200-014-H05 ST0293 Homo 34
459200 Y09306 Hs 30148 homeodomam-interacdng protein kinase 3 34
433791 AA719352 Hs 112718 ESTs 34
444911 U06117 Hs 250 xanthene dehydrogenase 34
439753 BE262233 Hs 7423 hypothetical protein from EUROIMAGE 2168 34
440933 AI208217 Hs 142879 ESTs 34
447726 AL137638 Hs 19368 matnlin 2 34
403849 Target Exon 34
422418 AK001383 Hs 116385 hypothedcal protein FU10521 33
439533 W76021 gb zd64c04 r1 Soares fetal heart NbHH19W 33
416422 H60457 ESTs, Moderately similar to ZN91 HUMAN Z 33
441668 AI611973 Hs 136313 ESTs 33
432890 NM 014442 Hs 279751 sialic acid binding Ig-like lecdn 8 33
412135 AW895309 gb QV4-NN0038-300300-155-307 NN0038 Homo 33
417130 AW276858 Hs 81256 S100 calcium-binding protein A4 (calcium 33
447854 AW138454 Hs 11594 ESTs 33
448048 BE281291 Hs 170408 ESTs, Moderately similar to A47582 B-cel 33
404632 NM.022490 Homo sapiens hypothetical prot 33
411565 AW851728 gb MR2-CT0222-011199-007-d06 CT0222 Homo 33 436267 AW450938 Hs 180115 ESTs 33
426625 T78300 Hs 300642 serologically defined colon cancer andg 33
401272 C9000559* gι|12314195lemb|CAB99338 1| (A 33
433128 AB021923 Hs 23367 EST-YD1 protein 33
401702 N .001171* Homo sapiens ATP-bind g cass 33
454363 AW816274 Hs 250154 hypothetical protein FU 12973 33
440332 AI218517 Hs 188051 ESTs 33
454177 AW807321 gb MR4-ST0062-240300-003-g05 ST0062 Homo 33
423784 AK000039 Hs 132826 Homo sapiens cDNA FU14913 fis, clone PL 33
440688 AW404591 Hs 1 7440 ESTs, Weakly similar to Z192.HUMAN ZINC 33
410267 AW978005 Hs 12600 N-ethylmaleimide-sensidve factor attach 33
455778 BE088746 gb CM2-BT0693-210300-123-d09 BT0693 Homo 33
430183 BE010038 gb PM3-BN0176-100400-001-g04 BN0176 Homo 32
451597 AW295250 Hs 207536 ESTs 32
451446 AI826288 Hs 171637 hypothedcal protein MGC2628 32
421353 AW292857 Hs 255130 ESTs 32
442710 AI015631 Hs 23210 ESTs 32
420560 AW207748 Hs 59115 ESTs 32
417404 NM.007350 Hs 82101 pleckstπn homology-like domain, family 32
437834 AA769294 Hs 283854 gb πz36g03 s1 NCI CGAP GCB1 Homo sapiens 32
430694 AA810624 Hs 30936 ESTs, Weakly similar to H2BH HUMAN HISTO 32
412021 AW885592 gb RC4-OT00 1 -090300-011 -g 11 OT0071 Homo 32
443431 AI056847 Hs 20654 ESTs 32
445774 AI254165 Hs 339968 ESTs 32
413335 AI613318 Hs 48442 ESTs 32
450692 H50603 Hs 94037 hypothedcal protein FU23053 32
411671 BE049094 ESTs 32
404592 NM_022739* Homo sapiens E3 ubiquidn lig 32
402747 Target Exon 32
428600 AW863261 Hs 242413 hypothedcal protein DKFZp434K1421 32
420300 AA258245 Hs 127573 Homo sapiens FKSG41 (FKSG41) mRNA, compl 32
445347 AF035318 Hs 12533 Homo sapiens clone 23705 mRNA sequence 32
458438 AI141520 Hs 151464 ESTs, Weakly similar to ALUC HUMAN "" 32
442314 AI311854 Hs 129220 ESTs 32
436291 BE568452 Hs 344037 protein regulator of cytokinesis 1 32
413249 AF167160 Hs 75251 DEAD/H (Asp-Glu-Ala-Asp/His) box binding 32
448789 BE539108 Hs 22051 hypothetical protein MGC15548 32
403291 Target Exon 32
436210 AI825420 Hs 197824 ESTs 32
418079 R40058 Hs 6911 ESTs 32
413951 AW051200 Hs 75640 natπuretic pepdde precursor A 32
435828 AA700705 Hs 13852 ESTs 32
437722 AW292947 Hs 122872 ESTs, Weakly similar to JU0033 hypotheti 32
451418 BE387790 Hs 26369 hypothedcal protein FU20287 32
405046 C3000978 gι|9280045|db||BAB01579 1| (ABO 31
444315 R07860 Hs 20039 ESTs 31
453096 AW294631 Hs 11325 ESTs 31
433835 AI806185 gb wf26a10 x1 Soares NFL T GBC_S1 Homo s 31
430608 R45584 Hs 23025 ESTs, Weakly similar to ALU5 HUMAN ALU S 31
453324 W26592 Hs 232089 ESTs 31
414884 R54418 Hs 183745 hypothedcal protein FLJ 13456 31
446862 AV660697 Hs 282700 ESTs 3 1
427241 AA399988 Hs 112087 Human DNA sequence from clone RP11-530N1 31
416486 H81336 Hs 37560 ESTs 31
429940 W25215 gb zb87a09 π Soares.senescent.fibroblas 3 1
430535 AW968485 gb EST380561 MAGE resequences, MAGJ Homo 31
439544 W26354 Hs 28891 hypothedcal protein FU11360, artemis p 3 1
437083 AW082597 Hs 244862 ESTs 3 1
435677 AA694142 Hs 293726 ESTs, Weakly similar to TSGA RAT TESTIS 31
458810 BE407125 Hs 231510 ESTs 31
443484 AI091458 Hs 134559 ESTs 31
427581 NM.014788 Hs 179703 KIAA0129 gene product 3 1
444016 AA448154 gb zw82h09 π Soares.tesds.NHT Homo sap 31
423337 NM.004655 Hs 127337 axin 2 (conducdn, axil) 3 1
403288 C1001737" gι|7511201 |pιr||T27904 hypothe 31
450125 AA005418 Hs 158186 ESTs 3 1
438138 R98299 Hs 177502 ESTs 3 1
436222 AI208737 Hs 122810 Homo sapiens cDNA FLJ11489 fis, clone HE 31
443433 R44743 Hs 301667 ESTs 3 1
443725 AW245680 Hs 9701 growth aπest and DNA-damage-inducible, 31
432044 AW972727 gb EST384819 MAGE resequences, MAGL Homo 31
405760 Target Exon 31
423789 AK002084 Hs 132851 hypothedcal protein FU11222 3 1
411605 AW006831 Hs 177530 ESTs 31
417893 AA290605 Hs 190002 ESTs 3 1
449246 AW411209 Hs 23363 hypothetical protein FU10983 3 1
429528 AI985303 Hs 99361 ESTs 31
456645 AF227156 Hs 110103 RNA polymerase 1 transcnpdon factor RR 31
412490 AW803564 Hs 288850 Homo sapiens cDNA FLJ22528 fis clone H 3 1
421679 AI475110 Hs 203933 ESTs 31
434503 T96231 Hs 17762 ESTs 31
450756 AI733488 Hs 144062 ESTs 3 1
415293 R49462 Hs 106541 ESTs 30 403212 NM_019595 Homo sapiens intersecdn 2 (IT 30
422757 AI909935 Hs 65551 Homo sapiens, Similar to DNA segment, Ch 30
427624 AA406245 Hs 24895 ESTs 30
449256 AA059050 Hs 59847 ESTs 30
411543 AW851248 gb IL3-CT0220-160200-066-F01 CT0220 Homo 30
409112 BE243971 Hs 50649 quinone oxidoreductase homolog 30
414403 AW969551 Hs 76064 nbosomal protem L27a 30
427418 AA402587 Hs 325520 LAT1-3TM protein 30
455481 AW948317 gb RCO-MT0015-280300-021-a09 MT0015 Homo 30
444396 T65213 Hs 4257 ESTs 30
407235 D20569 Hs 169407 SAC2 (suppressor of acdn mutadons 2, y 30
431431 AL096711 Hs 252953 Human DNA sequence from clone RP3-403A15 30
451391 AA017410 Hs 40568 ESTs 30
430251 AA609246 Hs 181451 ESTs . 30
420658 AW965215 Hs 130707 ESTs 30
442786 H50733 Hs 256261 ESTs, Moderately similar to ALU8.HUMAN A 30
440897 AW104275 Hs 148348 ESTs 30
444609 AW571659 Hs 278081 ESTs 30
433062 AK001757 Hs 281348 hypothedcal protein FU 10895 30
408523 AW833259 Hs 314287 ESTs 30
443477 R32325 Hs 221794 ESTs 30
423869 BE409301 Hs 134012 C1 q-related factor 30
405488 ENSP00000220888" ZINC FINGER TRANSCRIPTI 30
414988 C17535 gb C17535 Human placenta cDNA (TFu|iwara 30
440471 AA8861 6 Hs 307944 ESTs 30
416355 H49875 Hs 268906 ESTs 30
408926 AF217525 Hs 49002 Down syndrome cell adhesion molecule 30
424028 AF055084 Hs 153692 Homo sapiens cDNA FU14354 fis, done Y7 29
438201 AA780243 Hs 54647 ESTs 29
413851 AW897510 Hs 137387 ESTs 29
402229 BE262804 mitochondrial nbosomal protein S2 29
444145 BE153823 Hs 282385 ESTs, Weakly similar to 2004399A chromos 29
423770 AW976766 Hs 132776 Homo sapiens cDNA FLJ10077 fis, clone HE 29
439627 BE621702 Hs 29076 hypothedcal protein FU21841 29
414232 W86946 Hs 238246 hypothetical protein FLJ22479 29
400533 ENSP00000209376* PRED65 protein (Fragmen 29
440483 AI200836 Hs 150386 ESTs 29
443502 AI074528 Hs 133949 ESTs 29
449667 AB023227 Hs 23860 KIAA1010 protein 29
446809 AW590171 Hs 101413 ESTs 29
408788 AL134947 Hs 213956 Homo sapiens BAC clone RP11-102O5 from Y 29
413627 BE182082 Hs 246973 ESTs 29
449655 AI021987 Hs 59970 ESTs 29
407378 AA299264 Hs 57776 ESTs, Moderately similar to 138022 hypot 29
400090 Eos Control 29
454968 AW849046 gb IL3-CT0214-150300-085-H06 CT0214 Homo 29
423352 AA324808 Hs 193576 ESTs 29
426197 AA004410 Hs 100009 acyl-Coenzyme A oxidase 1, palmitoyl 29
452102 U04343 Hs 27954 CD86 antigen (CD28 antigen ligand 2, B7- 29
415346 Z43108 gb HSC13E071 normalized infant brain cDN 29
436726 AA324975 Hs 198689 ESTs, Weakly similar to T00079 hypotheti 29
442513 AF150207 Hs 207949 ESTs 29
425012 T77666 Hs 92414 Homo sapiens cDNA FU22030 fis clone H 29
402322 Target Exon 29
427235 AI126288 Hs 192232 ESTs 29
456412 AW749617 Hs 280776 tankyrase, TRF1-ιnteractιng ankyπn rela 29
431196 AW974436 Hs 154929 ESTs 29
439379 AA835002 Hs 125611 ESTs 29
423757 AL049337 Hs 132571 Homo sapiens mRNA, cDNA DKFZp564P016 (fr 29
446134 AW161234 Hs 13993 TBP-like 1 29
435645 AI052789 Hs 133263 ESTs 29
449385 AI650471 Hs 347290 ESTs 29
444161 N52543 Hs 142940 ESTs 29
406635 U07162 gb Human clone LNA11 autoandbody lg hea 29
419239 AA468183 Hs 184598 Homo sapiens cDNA FU23241 fis, clone C 29
458760 AI498631 Hs 111334 ferntin, light polypepdde 29
427245 AA421022 Hs 97739 ESTs 29
400658 ENSP00000237081" KIAA1217 PROTEIN (FRAGM 29
430701 AI760833 Hs 293971 ESTs 29
435294 T84084 Hs 196008 Homo sapiens cDNA FU11723 fis. clone HE 29
429927 NM_001115 Hs 2522 adenylate cyclase 8 (brain) 29
446160 AW392197 Hs 218003 ESTs 29
420674 NM 000055 Hs 1327 butyrγlchol esterase 29
424330 AW073953 Hs 333396 Homo sapiens cDNA FU13596 fis, clone PL 29
418915 AI474778 Hs 118977 ESTs 29
425922 AL157466 Hs 162751 Homo sapiens mRNA, cDNA DKFZp761E2423 (f 29
447512 AW958148 Hs 129454 ESTs 29
449990 AI279010 Hs 48821 ESTs 28
423779 AW071837 Hs 57971 ESTs 28
427395 AW298741 Hs 97861 ESTs, Moderately similar to 138022 hypot 28
416188 BE157260 Hs 79070 v-myc avian myelocytomatosis viral oncog 28
426746 J03626 Hs 2057 undine monophosphate synthetase (orotat 28
400362 AF068294 Hs 272414 Homo sapiens HDCMB45P mRNA, partial eds 28 457579 AB030816 Hs 36761 HRAS-like suppressor 28
451059 AW297465 Hs 267150 KIAA1409 protein 28
403903 C5001632" gι|10645308|gb|AAG21430 1|AC00 28
444491 AI151091 Hs 270714 ESTs 28
455899 BE155112 gb PM1-HT0350-151299-003-a03 HT0350 Homo 28
457292 AI921270 Hs 281462 hypothetical protein FU14251 28
428305 AA446628 Hs 2799 cartilage linking protein 1 28
435375 AI733610 Hs 187832 ESTs 28
409078 AW327515 Hs 346209 ESTs 28
436109 AA922153 Hs 132760 hypothedcal protein MGC15729 28
444656 AI277924 Hs 145199 ESTs 28
426384 AI472078 Hs 303662 hypothedcal protein FU13189 (FU13189) 28
424200 AA337221 gb EST41944 Endo etπal tumor Homo sapie 28
438243 AI581311 ESTs 28
434012 AA621425 Hs 186256 ESTs 28
402711 Target Exon 28
442955 AI683534 Hs 131583 ESTs 28
418319 AW611703 Hs 190173 ESTs. Weakly similar to A46010 X-linked 28
438934 BE220137 Hs 124323 ESTs 28
438689 AW129261 Hs 181672 ESTs 28
420083 AA478847 Hs 42484 hypothedcal protein FLJ10618 28
400315 U46120 Hs 193392 Human expressed unknown mRNA 28
433563 AI732637 Hs 277901 ESTs 28
458093 AI207788 Hs 343628 sialyltransferase 4B (beta-galactosidase 28
409157 AA064631 gb zf72c03 s1 Soares_pιneal_gland N3HPG 28
450597 AI701635 Hs 207077 ESTs 28
425300 AW601773 Hs 270259 ESTs 28
458617 Z25900 Hs 18724 Homo sapiens mRNA, cDNA DKFZp564F093 (fr 28
418312 AW972468 Hs 170307 Ral guanine nucleotide exchange factor R 28
430335 D80007 Hs 239499 KIAA0185 protein 28
454581 AW809189 gb MR4-ST0118-261099-012-e10 ST0118 Homo 28
419735 AW750056 Hs 169577 Homo sapiens cDNA FU 14743 fis, clone NT 28
436265 AA731331 Hs 190668 ESTs 28
439481 AF086294 Hs 125844 ESTs 28
441964 AA972619 Hs 20506 ESTs, Weakly similar to I38022 hypotheti 28
422648 D86983 Hs 118893 Melanoma associated gene 28
430503 AA533574 Hs 152274 ESTs 28
403942 Target Exon 28
420565 AI806770 Hs 30258 ESTs 28
439069 H63144 Hs 184178 ESTs, Weakly similar to ALUB.HUMAN "" 28
436480 AJ271643 Hs 87469 putadve acid-sensing ion channel 28
408137 AI694131 Hs 29002 KIAA1706 protein 28
451692 AL137422 Hs 26849 Homo sapiens mRNA, cDNA DKFZp761A1623 (f 28
419713 AW968058 Hs 92381 nudix (nucleoside diphosphate linked moi 28
452526 W38537 Hs 280740 hypothedcal protein MGC3040 28
414300 AI304870 Hs 188680 ESTs 28
419741 NM 007019 Hs 93002 ubiquitin earner protein E2-C 28
437933 AI276132 Hs 146155 ESTs 27
405941 Target Exon 27
443210 AI692649 Hs 9451 hypothedcal protein MGC13168 27
450651 W79000 Hs 44545 ESTs, Weakly similar to B34087 hypothed 27
426765 AA743603 Hs 172108 nucleopoπn 88kD 27
418886 AA993982 Hs 130858 ESTs 27
429483 AA974832 Hs 128708 ESTs 27
430426 AA478807 Hs 125173 ESTs 27
439019 AF085902 Hs 271737 ESTs 27
400924 Target Exon 27
458070 AW503578 Hs 209406 ESTs, Weakly similar to I38600 zinc fing 27
427299 AA830210 Hs 214263 ESTs, Moderately similar to ALU1 HUMAN A 27
442621 AI004333 Hs 130553 ESTs, Weakly similar to ALUA_HUMAN "" 27
437643 AL080280 gb Homo sapiens mRNA full length insert 27
426925 NM 001196 Hs 315689 Homo sapiens cDNA FU22373 fis, clone H 27
443392 AI055821 Hs 293420 ESTs 27
429972 AI700846 Hs 234518 πbosomal protein L23 27
438875 AA827640 Hs 189059 ESTs 27
422551 AW967284 gb EST379359 MAGE resequences, MAGJ Homo 27
446139 H77395 Hs 39749 ESTs 27
429115 AA446728 Hs 289020 Homo sapiens cDNA FU 14098 fis, clone MA 27
428612 AA770001 Hs 188778 ESTs 27
439947 AB006627 Hs 6788 astrotacdn 27
439699 AF086534 Hs 187561 ESTs, Moderately similar to ALU1 HUMA A 27
438335 AI498421 Hs 243168 ESTs 27
456680 AL137758 Hs 116072 Homo sapiens mRNA, cDNA DKFZp434H245 (fr 27
412074 S74683 Hs 73139 ADP-πbosyltransferase 1 27
412225 AW902042 gb QV0-NN1022-170400-193-C02 NN1022 Homo 27
438801 AA825971 Hs 124284 ESTs 27
442892 AI038379 Hs 131865 ESTs 27
432964 AF118395 Hs 279865 trans-prenyltransferase 27
403790 NM.001334* Homo sapiens cathepsm 0 (CTS 27
400335 Y13187 Hs 248068 Homo sapiens dmd gene, intron 11 27
415467 R60891 Hs 260274 ESTs 27
428715 AW293716 Hs 53126 ESTs 27
457750 AI651474 Hs 163944 ESTs 27 424480 AA341442 Hs 205299 ESTs 27
444822 BE164351 Hs 292767 hypothetical protein FU23109 27
432651 AW973744 Hs 293100 ESTs 27
439823 AW665287 Hs 124514 ESTs 27
457021 AW968934 Hs 173108 Homo sapiens cDNA FU21897 fis, clone H 27
440026 AA861299 Hs 160371 ESTs 27
446960 AW294936 Hs 156762 ESTs 27
435046 AA662772 Hs 174330 ESTs, Weakly similar to ALU1.HUMAN ALU S 27
431999 AL133573 Hs 272312 Homo sapiens mRNA, cDNA DKFZp434J2235 (f 27
458527 AI950256 Hs 224875 ESTs 27
445899 AI263736 Hs 145626 ESTs 27
404254 ENSP00000082468* DJ45P21 3 (butyrophilin 27
402344 Target Exon 27
426503 AA380153 gb EST93093 Skin tumor I Homo sapiens cD 27
446420 AW015693 Hs 135614 ESTs 27
426914 AA393328 Hs 194303 ESTs 27
407903 AI287341 Hs 154029 bHLH factor Hes4 27
433009 AA761668 gb nz24c08 s1 NCLCGAP.GCB1 Homo sapiens 27
403431 Target Exon 27
403290 C100010ir gι|4758212|ref|NP 004411 1| d 27
435143 R12375 Hs 194600 ESTs 27
416569 H64891 gb yr68h03 r1 Soares fetal liver spleen 27
428690 AI948490 Hs 98765 ESTs 27
425128 BE561929 Hs 154718 tumor protein D52-lιke 2 27
443361 AI792628 Hs 133273 ESTs 27
404053 Taiget Exon 27
435113 AA665469 Hs 117136 ESTs 26
405717 CX000838gι|10092633|reflNP 055314 1| pu 26
413098 BE065279 gb RC1-BT0314-030500-016-b09 BT0314 Homo 26
444884 AI201094 Hs 148540 ESTs 26
419015 T79262 Hs 14463 ESTs 26
423234 AA323534 Hs 296162 AD037 protein 26
406871 AA993857 Hs 180842 nbosomal protein L13 26
428670 AA431682 Hs 134832 ESTs 26
408371 AF161545 Hs 44439 hypothetical protein 26
413929 BE501689 Hs 75617 collagen, type IV, alpha 2 26
408369 R38438 Hs 182575 solute earner family 15 (H'1" transport 26
419817 AA743434 Hs 193778 ESTs 26
415788 AW628686 Hs 78851 KIAA0217 protein 26
427388 BE379610 Hs 177592 nbosomal protein, large, P1 26
451018 AW965599 Hs 247324 mitochondπal nbosomal protein S14 26
405863 Target Exon 26
454037 AW998716 gb PM4-BN0 67-250300-002-f11 BN0067 Homo 26
430147 R60704 Hs 234434 hairy/enhancer-of-split related with YRP 26
425480 AB023198 Hs 158135 KIAA0981 protein 26
407182 AA312551 Hs 230157 ESTs 26
439538 AA837323 Hs 56407 ESTs 26
449249 T52285 Hs 193115 Homo sapiens mRNA for KIAA1764 protein, 26
429569 AA454993 Hs 138343 ESTs, Weakly similar to 178885 sennerth 26
402936 ENSP00000217246" DJ803K15 1 (novel prate 26
420670 AW973577 ESTs 26
455409 AW936832 gb PM2-DT0023-050400-003-h03 DT0023 Homo 26
413151 H47969 Hs 141971 ESTs Weakly similar to ALU1_HUMAN ALU S 26
422484 AA568770 Hs 123158 Homo sapiens cDNA FU12830 fis, clone NT 26
400780 NM.007325" Homo sapiens glutamate recept 26
429258 AA448765 gb zx10e09 r1 Soares total.fetus Nb2HF8 26
448970 AW138582 gb UI-H-BM-acw-a-06-O-UI s1 NC? CGAP.Su 26
402615 C1003844' gι|6912550|reflNP_036483 1| cϋ 26
417099 BE537357 Hs 306995 hypothetical protein MGC5457 26
428397 AA428040 gb zw50e02 r1 Soares total fetus Nb2HF8 26
449164 AI632772 Hs 264165 ESTs 26
412584 X54870 Hs 74085 DNA segment on chromosome 12 (unique) 24 26
443635 AI080230 Hs 134214 ESTs 26
402981 Target Exon 26
433258 AI806626 Hs 207300 ESTs, Weakly similar to ALUB.HUMAN «» 26
428917 AA437337 Hs 16689 ESTs 26
418557 8E140602 Hs 246645 ESTs 26
445211 BE045601 Hs 118248 ESTs, Weakly similar to YC18.HUMAN HYPOT 26
404423 C8000067' gι|10432400|emb|CAC10290 1| (A 26
435953 AI767087 Hs 114142 ESTs 26
435937 AA830893 Hs 119769 ESTs 26
439220 AW295340 Hs 130417 ESTs, Weakly similar to Z195.HUMAN ZINC 26
419597 W73692 gb zd50c01 s1 Soares fetal heart NbHH19W 26
436852 AI814817 Hs 269099 ESTs 26
430569 AF241254 Hs 178098 angiotensin 1 converting enzyme (pepddy 26
443845 AI590084 Hs 148485 ESTs, Weakly similar to A47161 Mac-2-bιπ 26
414223 AA954566 Hs 238246 hypothetical protein FU22479 26
443770 AW815924 gb MR3-ST0218-191199-012-310 ST0218 Homo 26
450443 AA009847 Hs 120744 ESTs 26
435523 T62849 Hs 11090 membrane-spanning 4-domams, subfamily A 26
400492 C10001573" gι|7302749|gb|AAF57827 1| (AE 26
450202 AW969756 Hs 34145 ESTs Weakly similar to B49647 GTP-bindi 26
416845 H95279 Hs 293788 gb yu20h02 s1 Soares fetal liver spleen 26 446423 AW139655 Hs 150120 ESTs 26
447587 AW292139 Hs 115789 ESTs 26
437014 AA808757 Hs 222531 ESTs, Weakly similar to S59501 interfero 26
426411 AK000708 Hs 169764 hypothedcal protein FU20701 26
432668 AA558601 Hs 43296 ESTs 26
436682 AI590055 Hs 124110 ESTs 26
426894 AI204209 Hs 143911 ESTs 26
402605 Target Exon 26
457554 AA570111 Hs 155873 ESTs, Weakly similar to ALUE HUMAN "" 26
438166 N30158 Hs 122645 ESTs 26
443021 AA368546 Hs 8904 lg superfamily protein 26
427005 AA394228 Hs 97494 ESTs 26
437085 AA743935 Hs 202329 ESTs 26
408603 R25283 Hs 326416 Homo sapiens mRNA cDNA DKFZp564H1916 (f 26
431019 NM 005249 Hs 2714 forkhead box G1B 25
437287 AA748180 Hs 159346 hypothedcal protein FU21369 25
458552 AW136139 Hs 245856 ESTs 25
436350 AA713661 Hs 121091 ESTs 25
421988 AW450481 Hs 161333 ESTs 25
416704 H77795 Hs 39785 ESTs 25
447830 R98920 Hs 164314 ESTs 25
413278 BE563085 Hs 833 iπterferon-sdmulated protein, 15 kDa 25
406789 AI041403 nbosomal protein L29 25
433683 AI817723 Hs 22678 hypothedcal protein FU21832 25
433523 H29882 ESTs 25
452296 T65535 Hs 111539 ESTs 25
428878 AA436884 Hs 48926 ESTs 25
442476 AF069475 gb AF069475 Homo sapiens astrocytoma lib 25
452785 AL359942 Hs 296434 erythroid differentiation and denuclead 25
444422 AI768623 Hs 108264 ESTs 25
420579 AA278449 Hs 137429 ESTs 25
416505 H66470 Hs 16004 ESTs 25
402595 C1001578" gι|6759903|gb|AAF28099 1| (AF1 25
447930 R44574 Hs 107510 ESTs 25
459527 AW977556 Hs 291735 ESTs, Weakly similar to 178885 senneΛh 25
458421 AI279978 Hs 22547 ESTs 25
427527 AI809057 Hs 293441 immunoglobulin heavy constant mu 25
436035 AA703679 Hs 106999 ESTs, Weakly similar to SYT5 HUMAN SYNAP 25
453362 H14988 Hs 107375 ESTs 25
423600 AI633559 Hs 310359 ESTs 25
433325 AW206986 Hs 143905 ESTs 25
415983 AI436798 Hs 117078 Homo sapiens cDNA FU23028 fis, clone L 25
431198 AL047634 Hs 231913 ESTs 25
430530 AA480870 Hs 47660 ESTs 25
455276 BE176479 gb RC3-HT0585-160300-022-b09 HT0585 Homo 25
416665 H72974 gb yu28a10 s1 Soares fetal liver spleen 25
422352 AA766296 Hs 99200 ESTs 25
427613 AW273851 Hs 98025 ESTs 25
453685 AL110309 gb DKFZp564L0278 r1 564 (synonym hfbr2) 25
450508 R37408 Hs 101654 ESTs 25
436361 AA825814 Hs 149065 ESTs 25
427709 AI631811 Hs 180403 STRIN protein 25
432036 AF224266 Hs 272373 interieukin 20 25
422752 BE247253 Hs 21263 suppressor of potassium transport defect 25
413786 AW613780 Hs 13500 ESTs 25
439706 AW872527 Hs 59761 ESTs, Weakly similar to DAP1.HUMAN DEATH 25
451533 NM.004657 Hs 26530 serum depnvadon response (phosphaddyl 25
414959 D59968 Hs 45184 Homo sapiens cDNA FU12284 fis, clone MA 25
449919 AI674685 Hs 200141 ESTs 25
458891 AI659166 Hs 207144 ESTs 25
427140 AA398487 Hs 97642 ESTs 25
405239 U89281 oxidative 3 alpha hydroxysteroid dehydro 25
428450 NM 014791 Hs 184339 KIAA0175 gene product 25
443753 AW367578 Hs 134749 ESTs 25
432888 T86823 gb yd81a08 s1 Soares fetal liver spleen 25
445065 AI806657 Hs 302024 glycoprotein beta-Gal 3'-sulfotransferas 25
431202 AA495824 Hs 188822 ESTs, Weakly similar to A46010 X-linked 25
445658 AI469062 Hs 172660 ESTs 25
435330 R16769 Hs 173174 Homo sapiens cDNA FU14429 fis, clone HE 25
435703 AW630133 Hs 83313 GK003 protein 25
456232 AL040357 gb DKFZp434O0713_r1 434 (synonym htes3) 25
421955 AK000160 Hs 121576 Homo sapiens cDNA FU20153 fis, clone CO 25
420796 L34355 Hs 99931 sarcoglycan, alpha (50kD dystrophin-asso 25
425428 AL110261 Hs 157211 DKFZP586B0621 protein 25
437627 AW469925 Hs 257837 ESTs 25
408574 AA328046 Hs 46405 polymerase (RNA) II (DNA directed) polyp 25
418733 AA227714 Hs 179703 KIAA0129 gene product 25
440473 BE562314 Hs 98711 Homo sapiens, clone IMAGE 3677165, mRNA, 25
422106 D84239 Hs 111732 Fc fragment of IgG binding protein 25
411480 AW848022 gb IL3-CT0214-231299-053-A09 CT0214 Homo 25
436391 AJ227892 Hs 146274 ESTs 25
424947 R77952 ESTs, Weakly similar to alternatively sp 25
450831 R37974 Hs 25255 ESTs 25 447527 AI702896 Hs 42091 ESTs 25
424686 AA345504 gb EST51529 Gall bladder II Homo sapiens 25
453385 AW296101 Hs 252806 ESTs 25
TABLE 12B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
408292 10505071 AW178363 AW846011 AW845964 AW845988 AW845977 AW846002
409157 1103631 AA064631 AA722000AA064793
409189 110687.1 AA125984 AA127189 AA065075 AA070377 AA100017 AA079891 AA113255 AA075168 AA082764 AA083380 N84829 AA084752 AA076512 AA085119
AA085208 AA085045
411480 12470891 AW848022 AW848704 AW848168 AW848959 AW848476 AW848699 AW848700 AW848761
411537 1248899.1 BE0732508E073378 BE073379 AW850533 AW850529
411543 12491271 AW851248 AW851425 AW850805 AW851021 AW850905
411565 12497561 AW851728 AW851607 AW851621 AW851702 AW851647 AW851727 AW851658 AW851617 AW851628
411671 1253691 BE049094 AA700765 H86770 AA094646 R02483 C03868 N56170
411688 12540761 AW953440 T08189 AW857085
412021 12721561 AW885592 AW885594 AW885579 AW885651
412135 1279148.1 AW895309 AW895290 AW895307 AW895397 AW895378 AW895402 AW895403 AW895311 AW895298 AW895390 AW895488 AW895468 AW895481
AW895288
412225 12841081 AW902042 N77591
412811 132943.1 H06382 AW957730 AA352014 R13591 AA121201 D60420 BE263253 BE047862 Z41952 AI424991 AI693507 AI863108 AA599060 AI091148 AA598689
R39887 AA813482 AW016452 H06383 R41807 AI364268 AA620528 AI241940 AW089149 AW090733 AW088875 Z38240 AA121202 R17734
413098 13491151 BE065279 BE065306 BE065164 BE065389
413986 140720.1 Z43567 H24159 AA134240
414988 1511316.1 C17535 D59244 D58878 D79090
415131 15236801 D61119 D81508 D81734
415346 1534581 1 Z43108 F06295 R13085
416422 1593811 1 H60457 H68709 H73528 H54335 R87154
416569 16015671 H64891 R93444 R93458 R05590
416665 1607797.1 H72974 W28967
419597 18634131 W73692 W73836 W95650
420352 192979.1 BE258835 AW968316 AA258918 AW843305 R14744 AI580388 BE071923 R36280
420670 1954421 AW973577AA553621 AA279187
422551 2177671 AW967284 AA312192 AA312203
424009 2341771 F11690 AW965370 AA333586 D30830
424200 2365951 AA337221 AA336756 AW966196
424686 2424861 AA345504 AA345251 AW963243
424947 2452471 R77952 AA348809 AW959960 AW959962 AI565552 AW070702 AA973910 R85973
425146 247244.1 AW954627 AW954629 AA351258 R25935
425331 2501991 AW962128 AA355353 AA427363
426503 2682831 AA380153 AA380233 AW963529
428397 2909941 AA428040 AW889864 AA836434
429258 3019171 AA448765 C04967 C03045 AA658293
429940 3108841 W25215 AA461079AA461391
430183 314122 BE010038 AA676833 AI311783 T86895 W68032 BE064393 BE064394 BE157228 BE183282 AI936370 AA552514 T67280 AA039909
430535 3196431 AW968485 AW968670 AA480922 BE350425
432044 3407731 AW972727 AA524829 AW972733
432646 3519091 AW753310AW974000AA557840 AA558570 AW751539
432888 355780.1 T86823 AI821425 AI732232 AA569589 AA570737
433009 357371 1 AA761668 AA573621 R92814 R09670
433523 3688731 H29882 AW665533 AW149901 AI572917 AA598500 AI686466 AI336390 AW864390 AW864320
433835 3747581 AI806185 AA610063 AI693089 AI693075
434589 389291 AF147363 T47219 T47218
436608 423613 AA628980 AI126603 BE504035
437034 4317131 AA742643 AA808575 AW976668
437643 439981 AL080280 T73124 H02689 AL080281
438243 4530721 AI581311 AA781682 AA781678
438458 4578371 AW975186 AA807807 D29548
439533 47349.1 W76021 AF088052 W72465
442476 5435471 AF069475 AF069477 AF069476
443770 5798491 AW815924 AW815926 AI085174
444016 588991 AA448154 AV647571
448970 7912541 AW138582 AI638298 AI631640 AI963868 AI611082
450166 826771 AA429504 R41904 AA279467 H09648 AA007236
453685 9777341 AL110309 AW088119 H22881
454037 9962871 AW998716AW022148 N68020
454177 1049351.1 AW807321 AW807262 AW177104 AW807319 AW807115 AW807344 AW807324 AW178116 BE141575 AW845849 AW807105 AW845868 BE140942
AW807178 AW807167 AW807398 AW807320 AW807306 AW845866
454451 12065021 AW846706 AW846703 AW752167 AW846700 AW846699 AW752176 AW846694
454457 1207274.1 AW753456 AW753036 AW854868 AW854862
454581 12257101 AW809189 AW809219 AW813574
454765 12339051 AW819629 AW854320
454860 12377321 AW835767 AW835537 BE160187
454968 12470291 AW849046 AW847956 AW849039 AW847957 AW848279 AW848698 AW849034 AW849033
455104 12537371 BE064863 BE153698 AW856751 BE153820 BE064737 BE153674 BE064730 BE065062 BE153536 AW856622 BE155079 BE064651 BE153665
BE064650 BE064691
455276 1272541.1 BE176479 BE176678 BE176357 BE 176550 AW886079 BE176676 BE176615 BE176555 BE176489 BE176610 BE176362 455409 1288355.1 AW936832 AW936609 AW936657 AW936611 AW936739 AW936734 AW936779 AW936688 AW936659 AW936738 AW936827 AW936737 AW936736 AW936740 AW936833 AW936777 AW936830 AW936834 AW936829 AW936772 AW936638 AW936658 AW936636 AW936774 AW936778 AW936766 AW936776 AW936831 AW9
455481 1293182 1 AW948317 AW948322 AW948329 AW948316 AW948298 AW948330 AW94832
455646 1348557 1 BE064420 BE064435 BE064429 BE064414 BE064400 BE064517
455778 1364506.1 BE088746 BE088802 BE088755 BE088876 BE088947 BE088881 BE088952
455899 1381547 1 BE155112 BE155154 BE155087 BE155247 BE155499 BE155367 BE155452
456232 168294 1 AL040357 AA883621 AA203230
456304 176820 1 AI820973 AI734077 AI820984 AA225796 AA225060 AA225101
457364 328154 1 AW971037 AA508019 AA492345
TABLE 12C
Pkey Unique Eos probeset idendfier number
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numb sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted
NLpos dor i Indicates nucleodde posidons of predicted exons
Pkey Ref Strand Nt position
400492 9213749 Minus 123881-124090
400533 6981826 Minus 277132-277595
400645 8117693 Minus 58471-58716
400658 8118459 Minus 73525-73644
400780 8131663 Minus 118372-118619
400814 8569925 Minus 72840-72924,74761-74849
400924 7107613 Minus 30309-30498
401272 9797373 Minus 98374-98509
401454 9186923 Minus 114659-114832
401702 1871197 Minus 68182-68325
402229 9965022 Minus 15739-15951,16166-16779
402274 2935596 Plus 5604-6527
402322 7630359 Minus 75078-75203
402344 8099256 Minus 76812-79040
402595 7705171 Plus 37870-37923,39664-39717,71711-71764
402604 9909420 Plus 20393-20767
402605 9909420 Minus 47680-47973
402615 9926801 Plus 131390-132157
402711 8901247 Minus 114306-115418
402747 9212492 Minus 7105-7357
402855 9662953 Minus 59763-59909
402936 8894303 Plus 51655-51771
402981 9944246 Minus 45716-45889
403108 8980955 Plus 93253-93667
403212 7630897 Minus 156037-156210
403288 8081479 Plus 133763-133899,135813-135958
403290 8083176 Plus 19288-20076
403291 7230870 Plus 95177-95435
403349 8569773 Minus 167815-168374
403431 7139839 Plus 56509-56860
403481 9965004 Plus 93496-93633
403696 3135242 Minus 143467-143634
403790 8084957 Minus 87826-87947,89835-90002
403849 7708855 Plus 95043-96519
403903 7710671 Minus 101165-102597
403942 7711825 Minus 99606-99757
403961 7596976 Minus 110393-110603
404053 3548785 Plus 61797-64205
404120 7342152 Plus 135775-136000
404185 4572584 Minus 129171-129327
404254 9367203 Plus 129350-129873
404272 9885189 Plus 83207-83355,84358-84496,90519-90720,91371-91447
404423 7407959 Plus 34438-34618
404584 9857511 Plus 138651-139153
404592 9943965 Minus 39067-39225
404632 9796668 Plus 45096-45229
405046 7596829 Minus 4373-4528
405183 7209940 Plus 12335-12653
405238 7249119 Minus 51728-51836
405239 7249119 Plus 144345-144464,144690-144836,151750-151883,152407-152484
405348 2914717 Minus 43310-43462
405488 7131455 Minus 75771-75883.105295-105398,134754-134875
405558 1621110 Plus 4502-4644,5983-6083
405717 9588573 Plus 11275-11973
405760 6066938 Minus 37424-38045
405863 7657810 Plus 49410-49620
405941 6758796 Plus 2798-3444
406395 9256242 Minus 20805-20960
406478 9857502 Plus 68314-68523,68853-68950
406481 9864741 Minus 91439-91579
TABLE 13A 964 GENES UP-REGULATED IN LOWER GRADE GLIOBLASTOMA COMPARED TO NORMAL ADULT TISSUES
Table 13A lists about 678 genes up-regulated in lower grade glioblastoma (LGG) compared to normal normal adult tissues These were selected from 59680 probesets on the
Affymetnx/Eos Hu03 GeneChip array such that the rado of "average" LGG to "average* normal tissues was greater than or equal to 30 The "average" LGG level was set to the &5* percendle amongst vanous LGG tumors The "average" normal dssue level was set to the 85* percendle amongst various non-malignant adult dssues In order to remove gene- specific background levels of non-specific hybndizadon, the 10"' percendle value amongst the vaπous non-malignant tissues was subtracted from both the numerator and the denominator before the ratio was evaluated
Pkey Uniqi ιe Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene title
R1 Rado of LOWER GRADE GLIOBLASTOMA to NORMAL ADULT TISSUES
Pkey ExAccn UnigenelD Unigene Title R1
427343 AI880044 Hs 176977 protein kinase C binding protein 2 67 6
409389 AB007979 Hs 301281 Homo sapiens mRNA, chromosome 1 specific 582
418375 NM 003081 Hs 84389 synaptosomal-associated protein, 25kD 538
431917 D16181 Hs 2868 penpheral myelin protein 2 506
428321 AI699994 Hs 2868 penpheral myelin protein 2 483
426325 028114 Hs 169309 yelin-associated oligodendrocyte basic 443
435147 AL133731 Hs 4774 Homo sapiens mRNA, cDNA DKFZp761C1712 (f 442
456759 BE259150 Hs 127792 delta (Drosophιla)-lιke 3 438
415817 U88967 Hs 78867 protein tyrosine phosphatase, receptor-t 408
429007 D80642 gb HUM092E09B Human fetal brain (TFujiwa 40 1
417183 R52089 Hs 172717 ESTs 388
430838 N46664 Hs 169395 hypothedcal protein FU12015 368
413472 BE242870 Hs 75379 solute earner family 1 (glial high affi 349
425088 AA663372 Hs 169395 hypothedcal protein FU12015 344
429276 AF056085 Hs 198612 G protein-coupled receptor 51 342
424140 Z48051 Hs 141308 myelin oligodendrocyte glycoprotein 339
450133 AW969769 Hs 105201 ESTs 338
423849 AL157425 Hs 133315 Homo sapiens mRNA, cDNA DKFZp761J1324 (f 328
413333 M74028 Hs 75297 fibroblast growth factor 1 (acidic) 32 8
449494 AW237014 Hs 315369 Homo sapiens cDNA FU23075 fis, clone L 31 3
402604 Target Exon 30 3
412733 AA984472 Hs 74554 KIAA0080 protein 28 8
416829 AB013805 Hs 80220 catenin (cadhenn-associated protein), d 28 2
439239 AI031540 Hs 235331 ESTs 27 9
444378 R41339 Hs 47860 neurotrophic tyrosine kinase, receptor. 27 1
439415 F05538 Hs 4273 ESTs 262
425048 H05468 Hs 164502 ESTs 25 5
429903 AL134197 Hs 93597 cyclin-dependent kinase 5, regulatory su 253
425057 AA826434 Hs 1619 achaete-scute complex (Drosophila) homol 240
425799 T08133 Hs 182906 Homo sapiens mRNA for KIAA1872 protein, 23 5
447359 NM 012093 Hs 18268 adenylate kinase 5 235
425842 AI587490 Hs 159623 NK-2 (Drosophila) homolog B 23 2
423853 AB011537 Hs 133466 slit (Drosophila) homolog 1 23 2
435708 AI362949 Hs 75169 ESTs 229
437268 AI754847 Hs 227571 regulator of G-protem signalling 4 21 6
409395 U46745 Hs 336678 dystrobrevm alpha 21 1
441285 NM.002374 Hs 167 microtubule-associated protein 2 204
422656 AI870435 Hs 1569 LIM homeobox protein 2 200
425523 AB007948 Hs 158244 KIAA0479 protein 197
437204 AL110216 Hs 22826 ESTs, Weakly similar to 155214 salivary 195
416370 N90470 Hs 203697 ESTs, Weakly similar to I38022 hypotheti 194
441497 R51064 Hs 23172 ESTs 193
453392 U23752 Hs 32964 SRY (sex determining region Y)-box 11 191
408604 D51408 Hs 21925 ESTs 18 9
413597 AW302885 Hs 117183 ESTs 188
422980 N46569 Hs 76722 CCAAT/enhancer binding prote (C/EBP), 188
428392 H10233 Hs 2265 secretory granule, neuroendocπne protei 186
429466 M85835 Hs 12827 ESTs 18 2
448302 AI480208 Hs 182906 Homo sapiens mRNA for KIAA1872 protein, 18 2
439199 R40373 Hs 26299 ESTs 174
448743 AB032962 Hs 21896 KIAA1136 protein 174
418338 NM 002522 Hs 84154 neuronal pentraxm I 173
444513 AL120214 HS 7117 glutamate receptor, lonotropic, AMPA 1 17 2
444783 AK0O1468 Hs 62180 anillm (Drosophila Scraps homolog) act 17 1
447004 AW296968 Hs 157539 ESTs 168
425984 AW836277 Hs 165636 hypothetical protein DKFZp761C07121 16 5
448672 AI955511 Hs 225106 ESTs 161
452372 AI885742 Hs 228474 ESTs 158
424120 T80579 Hs 290270 ESTs 157
424581 M62062 Hs 150917 catenin (cadheπn-associated protein), a 156
424790 AL119344 Hs 13326 ESTs, Weakly similar to 2004399A chromos 154
426269 H15302 Hs 168950 Homo sapiens mRNA, cDNA DKFZp566A1046 (f 152
446692 Z44514 Homo sapiens mRNA for KIAA1763 protein, 15 2
453642 AI370936 Hs 34074 dipepddylpepddase VI 149
429037 X81895 Hs 194765 H sapiens GENX-5624 mRNA, ϊ UTR 147
441440 AI807981 Hs 30495 ESTs 146
429927 NM 001115 Hs 2522 adenylate cyclase 8 (brain) 146
415849 R20529 Hs 6806 ESTs 144
418110 R43523 Hs 217754 hypothetical protein FU22202 14 2
434277 X77748 Hs 3786 glutamate receptor, metabotropic 3 140
409638 AW450420 Hs 21335 ESTs 140
441350 AB020690 Hs 7782 paraneoplasdc andgen MA2 139
415734 NM.01 747 Hs 78748 KIAA0237 gene product 137 424945 AI221919 hypothetical protein FU10582 136
426344 H41821 Hs 322469 traπscnptional activator of the c-fos p 134
446372 AB020644 Hs 14945 long fatty acyl-CoA synthetase 2 gene 13 3
429946 R49390 Hs 254129 KIAA1678 133
444119 R41231 Hs 184261 ESTs, Weakly similar to T26686 hypothed 133
438380 T06430 Hs 6194 chondroihn sulfate proteoglycan BEHAB/b 13 2
415910 U20350 Hs 78913 chemokine (C-X3-C) receptor 1 13 2
412266 N59006 Hs 26133 ESTs 13 2
436878 BE465204 Hs 47448 ESTs 131
428536 AI143139 Hs 2288 vis in-like 1 13 1
425649 U30930 Hs 158540 UDP glycosyltransferase 8 (UDP-galactose 13 1
428982 NM 005097 Hs 194704 leuαne-πch, glioma inacdvated 1 130
437948 AA772920 Hs 303527 ESTs 130
444124 R43097 Hs 6818 ESTs 129
428342 AI739168 Homo sapiens cDNA FU13458 fis, clone PL 12 7
419249 X14767 Hs 89768 gamma-aminobutync acid (GABA) A recepto 127
412959 D87458 Hs 75090 KIAA0282 protein 126
419863 AW952691 Hs 93485 Homo sapiens mRNA, cDNA DKFZp761D191 (fr 126
431467 N71831 Hs 256398 Homo sapiens mRNA, cDNA DKFZp434E0528 (f 126
431019 NM 005249 Hs 2714 foitøiead box GIB 124
420547 AF155140 Hs 98738 gonadotropm-regulated tesdcular RNA he 12 4
430091 AB032958 -Hs 233023 KIAA1132 protein 124
448595 AB014544 Hs 21572 KIAA0644 gene product 12 2
447342 AI199268 Hs 19322 Homo sapiens, Similar to RIKEN cDNA 2010 122
409049 AI423132 Hs 146343 ESTs 120
421264 AL039123 Hs 103042 microtubule-associated protein 1B 11 9
451952 AL120173 Hs 301663 ESTs 11 9
411305 BE241596 Hs 69547 myelin basic protein 11 8
433551 AI985544 Hs 12450 protocadheπn 9 11 6
431988 AC002302 Hs 77202 protein kinase C, beta 1 11 6
415170 R44386 Hs 164578 ESTs 11 5
408562 AI436323 Hs 31141 Homo sapiens mRNA for KIAA1568 protein, 11 4
435501 AW051819 Hs 129908 KIAA0591 protein 11 4
429656 X05608 Hs 211584 neurofilament, light polypeptide (68kD) 11 1
423419 R55336 Hs 23539 ESTs 11 1
424432 AB037821 Hs 146858 protocadhenn 10 109
433896 AW294729 Hs 274461 ESTs 109
415293 R49462 Hs 106541 ESTs 109
447101 N72185 Hs 44189 ESTs 109
440105 AA694010 Hs 6932 Homo sapiens clone 23809 mRNA sequence 109
438054 AA776626 Hs 169309 ESTs 108
433597 AA708205 Hs 100343 ESTs 10 7
421659 NM 014459 Hs 106511 protocadhenn 17 106
445102 AW204610 Hs 22270 ESTs 106
425154 NM 001851 Hs 154850 collagen, type IX, alpha 1 106
451625 R56793 Hs 106576 alanine glyoxylate aminotransferase 2-lι 106
435191 R15912 Hs 4817 Homo sapiens clone 24461 mRNA sequence 106
450154 R15891 Hs 281587 Human (clone CTG-A4) mRNA sequence 105
407886 AW969688 Hs 100826 ESTs 104
420345 AW295230 Hs 25231 ESTs 104
428728 NM 016625 Hs 191381 hypothedcal protein 103
424997 AL138167 Hs 96920 ESTs 103
440184 AB002297 Hs 7022 dedicator of cyto-kinesis 3 10 2
419078 M93119 Hs 89584 insul oma-associated 1 102
445495 BE622641 Hs 38489 ESTs, Weakly similar to I38022 hypothed 10 1
416857 AA188775 Hs 292453 ESTs 100
445041 T64183 Hs 282982 solute earner 10 0
419271 N34901 Hs 238532 ESTs 98
446711 AF169692 Hs 12450 protocadheπn 9 98
426847 S78723 Hs 298623 5-hydroxytιγptamιne (serotonin) receptor 97
427304 AA761526 Hs 163853 ESTs 97
418097 R45137 Hs 21868 ESTs 97
449300 AI656959 Hs 346514 ESTs 97
419985 H66373 Hs 5856 ESTs, Highly similar to bA393J163 [H sa 97
443785 AW449952 Hs 190125 basic-helix-loop-helix-PAS protein 95
415486 H12214 Hs 13284 ESTs, Weakly similar to 2109260A B cell 95
453220 AB033089 Hs 32452 Homo sapiens mRNA for KIAA1263 protein, 95
438209 AL120659 Hs 6111 aryl-hydrocarbon receptor nuclear transl 94
424028 AF055084 Hs 153692 Homo sapiens cDNA FU14354 fis, clone Y7 94
419683 AA248897 Hs 48784 ESTs 94
414175 AI308876 Hs 103849 hypothetical protein DKFZp761D112 92
400292 AA250737 Hs 72472 BMP-R1B 92
408947 AL080093 Hs 49117 Homo sapiens mRNA, cDNA DKFZp564N1662 (f 92
454048 H05626 Hs 6921 ESTs 92
454027 R40192 Hs 21527 Human DNA sequence from done GS1-115M3 9 1
441016 AW138653 Hs 25845 ESTs 90
425187 AW014486 Hs 22509 ESTs 90
445568 H00918 Hs 268744 KIAA1796 protein 89
453941 U39817 Hs 36820 Bloom syndrome 89
422411 AW749443 Hs 22511 ESTs 88
447350 AI375572 Hs 172634 ESTs 88
424481 R19453 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbac 87
448902 Z45998 Hs 22543 Homo sapiens mRNA, cDNA DKFZp761l1912 (f 87 448986 H42169 Hs 347310 hypothetical protein FU 14627 86
423135 N67655 Hs 26411 ESTs 85
418030 BE207573 Hs 83321 neuromedin B 84
448769 N66037 Hs 38173 ESTs 84
407748 AL079409 Hs 38176 KIAA0606 protein SCN Orcadian Oscillat 83
400293 N51002 Hs 306480 Homo sapiens mRNA, cDNA DKFZp761E2112 (f 83
415279 F04237 Hs 1447 glial fibnllaiy acidic protein 82
451516 A.800515 Hs 12024 ESTs 82
419629 AB020695 Hs 91662 KIAA0888 protein 82
437034 AA742643 gb ny91c01 s1 NCI_CGAP_GCB1 Homo sapiens 82
456965 AW131888 Hs 172792 ESTs, Weakly similar to hypothetical pro 81
417417 F05745 Hs 89512 ATPase, Ca transporting, plasma membrane 8 1
452279 AA286844 Hs 61260 hypothedcal protein FU13164 8 1
422864 AA318323 Hs 12827 gb EST20390 Redna II Homo sapiens cDNA 81
452526 W38537 Hs 280740 hypothedcal protein MGC3040 80
435793 AB037734 Hs 4993 KIAA1313 protein 79
415669 NM 005025 Hs 78589 senne (or cyste e) proteinase iπhibito 79
407168 R45175 Hs 117183 ESTs 79
447414 D82343 Hs 74376 neuroblastoma (nerve dssue) protein 78
442710 AI015631 Hs 23210 ESTs 78
416836 D54745 Hs 80247 cholecystokinm 78
419721 NM 001650 Hs 288650 aquapoπn 4 77
438080 AA777381 Hs 291530 ESTs, Weakly similar to ALUC_HUMAN "" 77
436109 AA922153 Hs 132760 hypothedcal protein MGC15729 77
428845 AL157579 Hs 153610 KIAA0751 gene product 77
448321 NM 005883 Hs 20912 adeπomatous polyposis coli like 77
410305 AF030409 Hs 62185 solute earner family 9 (sodium/hydrogen 76
443392 AI055821 Hs 293420 ESTs 76
429038 AL023513 Hs 194766 seizure related gene 6 (mouse)-lιke 75
418738 AW388633 Hs 6682 solute earner family 7, (cationic ammo 75
423361 AW170055 Hs 47628 ESTs 75
447198 D61523 Hs 283435 ESTs 75
448555 AI536697 Hs 159863 ESTs 75
458332 AI000341 Hs 220491 ESTs 74
407034 U84540 gb Human dystrobrevm isoform DTN-3 (DTN 74
425354 U62027 Hs 155935 complement component 3a receptor 1 74
426814 AF036943 Hs 172619 myelin transcnpdon factor 1-lιke 74
448507 AL133109 Hs 21333 Homo sapiens mRNA, cDNA DKFZp566N1047 (f 74
439845 AL355743 Hs 56663 Homo sapiens EST from clone 41214, full 74
449078 AK001256 Hs 22975 KIAA1576 protein 73
410102 AW248508 Hs 279727 ESTs, homologue of PEM-3 [Oona savignyi 72
425741 AF052152 Hs 159412 Homo sapiens clone 24628 mRNA sequence 72
440210 AW674562 Hs 125296 ESTs 72
415651 AI207162 Hs 3815 stathmin-like-protein RB3 72
428409 AW117207 Hs 98523 ESTs 7 1
413409 AI638418 Hs 1440 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 7 1
443992 AW022228 Hs 322922 ESTs 7 1
455601 AI368680 Hs 816 SRY (sex determining region Y)-box 2 7 1
427540 R12014 Hs 20976 ESTs 70
439979 AW600291 Hs 6823 hypothedcal protein FU10430 70
424893 AW295112 Hs 153648 Homo sapiens cDNA FU13303 fis, clone OV 70
452355 N54926 Hs 29202 G protein-coupled receptor 34 70
414696 AFOO2020 Hs 76918 Niemann-Pick disease, type C1 70
440152 AB002376 Hs 7006 KIAA0378 protein 70
454293 H49739 Hs 134013 ESTs, Moderately similar to HK61_HUMAN H 70
425782 U66468 Hs 159525 cell growth regulatory with EF-hand doma 70
416805 F13271 Hs 79981 Human clone 23560 mRNA sequence 70
419991 AJ000098 Hs 94210 eyes absent (Drosophila) homolog 1 70
424343 AW956360 Hs 4748 adenylate cyclase activating polypeptide 69
408369 R38438 Hs 182575 solute earner family 15 (HT?- transport 69
449605 AW138581 Hs 198416 ESTs 69
444396 T65213 Hs 4257 ESTs 69
444165 AL137443 Hs 10441 hypothetical protein FU 11236 69
414245 BE148072 Hs 75850 WAS protein family, member 1 69
412155 R38167 Hs 12449 Homo sapiens transmembrane protein HTMP1 69
424624 AB032947 Hs 151301 Ca2- lependent activator protein for seer 69
448681 AL109781 Hs 21754 Homo sapiens mRNA full length insert cDN 69
411379 AI816344 Hs 12554 ESTs. Weakly similar to NPL4 HUMAN NUCLE 69
446782 AI653048 Hs 144006 ESTs 68
426919 AL041228 ELAV (embryonic lethal, abnormal vision, 68
423346 AI267677 Hs 127416 synaptoian 1 68
436643 AA757626 Hs 10941 ESTs, Weakly similar to IPP1_HUMAN PROTE 68
414922 D00723 Hs 77631 glycine cleavage system protein H (am o 68
410037 ABO20725 Hs 58009 KIAA0918 protein 68
442613 AI004002 Hs 130522 Kv channel-interacting protein 1 68
413589 AW452631 Hs 313803 ESTs Highly similar to AF157833 1 noncl 68
422175 N79885 Hs 6382 ESTs Highly similar to T00391 hypotheti 68
421141 AW117261 Hs 125914 ESTs 67
452786 R61362 Hs 106642 ESTs, Weakly similar to T09052 hypothed 67
441916 AA993571 Hs 129075 ESTs 67
448533 AL119710 Hs 21365 nucleosome assembly protein 1-lιke 3 67
428037 N47474 Hs 89230 potassium intermediate/small conductance 67
423343 AA324643 Hs 246106 ESTs 67 456723 Z43902 Hs 4748 adenylate cyclase acbvadng polypeptide 67
414214 D49958 Hs 75819 glycoprotein M6A 67
434811 AW971205 Hs 114280 ESTs 67
424922 BE386547 Hs 217112 hypothedcal protein MGC10825 67
449328 AI962493 Hs 345303 ESTs 66
431553 X78075 Hs 2799 cartilage linking protein 1 66
420156 AW449258 Hs 6187 ESTs 66
431117 AF003522 Hs 250500 delta (Drosophιla)-lιke 1 66
422960 AW890487 Hs 63984 cadhenn 13, H-cadheπn (heart) 66
429239 AA448419 Hs 45209 ESTs 65
453924 R49295 Hs 24886 ESTs 65
433929 AI375499 Hs 27379 ESTs 65
426529 AF090100 Hs 1 0241 Homo sapiens clone IMAGE 23915 65
414683 S78296 Hs 76888 hypothedcal protein MGC12702 64
409746 NM 004794 Hs 56294 FIAB33A, member RAS oncogene family 64
419169 AW851980 Hs 262346 ESTs, Weakly similar to S72482 hypothed 64
453590 AF150278 Hs 33578 KIAA0820 protein 64
422263 AA307639 Hs 129908 KIAA0591 protein 64
421688 AK000307 Hs 106825 hypothedcal protein FU20300 64
447197 R36075 gb yh88b01 s1 Soares placenta Nb2HP Homo 63
425588 F07396 Hs 46627 ESTs 63
410366 AI267589 Hs 302689 hypothetical protein 63
419498 AL036591 Hs 20887 hypothetical protein FU10392 63
446997 AA383439 Hs 16758 Spιr-1 protein 63
427958 AA418000 Hs 98280 potassium intermediate/small conductance 63
445908 R13580 Hs 13436 Homo sapiens clone 24425 mRNA sequence 63
412068 S72043 Hs 73133 metallothionem 3 (growth inhibitory fac 63
452834 AI638627 Hs 105685 KIAA1688 protein 63
408790 AW580227 Hs 47860 neurotrophic tyrosine kinase, receptor. 63
418512 AW498974 diacylglycerol kinase, zeta (104kD) 62
410099 AA081630 K1AA0036 gene product 62
452744 AI267652 Hs 246107 Homo sapiens mRNA, cDNA DKFZp434E082 (fr 62
427897 NM 017413 Hs 303084 apelin, peptide ligand for APJ receptor 62
416427 BE244050 Hs 79307 Rac/Cdc42 guanine exchange factor (GEF) 62
439274 AF086092 Hs 48372 ESTs 62
431552 AI815863 Hs 259873 axonal transport of synaptic vesicles 62
439607 BE540565 Hs 159460 ESTs 62
408950 AA707814 Hs 14945 long fatty acyl-CoA synthetase 2 gene 62
412709 AL022327 Hs 74518 KIAA0027 protein 62
435624 AF218942 Hs 24889 formιn 2 6 1
425977 R15138 Hs 165570 Homo sapiens clone 25052 mRNA sequence 6 1
420077 AW512260 Hs 87767 ESTs 6 1
457005 AJ007421 Hs 172597 sal (Drosophιla)-lιke 3 6 1
440471 AA886146 Hs 307944 ESTs 6 1
423770 AW976766 Hs 132776 Homo sapiens cDNA FLJ10077 fis, clone HE 6 1
438624 AA889055 Hs 123468 ESTs 6 1
452752 AW044058 Hs 33578 KIAA0820 protein 6 1
438208 AL041224 Hs 65379 ESTs 6 1
416072 AL110370 Hs 79000 growth associated protein 43 6 1
407808 AA663559 Hs 279789 histone deacetylase 3 6 1
433701 AW445023 Hs 15155 ESTs 6 1
419704 AA429104 Hs 45057 ESTs 6 1
429250 H56585 Hs 198308 tryptophan nch basic protein 6 1
433244 AB040943 Hs 271285 KIAA1510 protein 60
422544 AB018259 Hs 118140 KIAA0716 gene product 60
420133 AA426117 Hs 155543 ESTs 60
440491 R35252 Hs 130558 ESTs, Weakly similar to 2109260A B cell 60
422728 AW937826 Hs 103262 ESTs, Weakly similar to ZN91 HUMAN ZINC 60
415257 F03016 Hs 27513 ESTs 59
417160 N76497 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbac 59
430188 AL049242 Hs 234794 Homo sapiens mRNA, cDNA DKFZp564B083 (fr 59
437372 AA323968 Hs 283631 hypothetical protein DKFZp547G183 59
430471 AF064845 Hs 241523 hypothetical protein FU10142 59
433523 H29882 ESTs 59
408926 AF217525 Hs 49002 Down syndrome cell adhesion molecule 59
427317 AB028955 Hs 175780 KIAA1032 protein 59
426140 AF131798 Hs 343768 Homo sapiens clone 25119 mRNA sequence 59
409892 AW956113 Hs 7149 gb EST368183 MAGE resequences, MAGD Homo 58
459516 AI049662 Hs 246858 EST 58
442910 AI365130 Hs 11307 ESTs, Weakly similar to T19326 hypothed 58
414737 AI160386 Hs 125087 ESTs 58
424332 AA338919 Hs 101615 ESTs 58
403142 NM.002706" Homo sapiens protein phosphat 58
420111 AA255652 gb zs21h11 r1 NCI CGAP GCB1 Homo sapiens 58
450813 AI739625 Hs 203376 ESTs 58
402145 Target Exon 58
434792 AA649253 Hs 132458 ESTs 58
422421 AA325138 Hs 235873 hypothedcal protein FU22672 58
445745 AB007924 Hs 13245 KIAA0455 gene product 58
420608 BE548277 Hs 103104 ESTs 58
451407 AA131376 Hs 343809 fibroblast growth factor 128 57
441102 AA973905 intermediate filament protein syncoilm 57
424560 AA158727 Hs 150555 protein predicted by clone 23733 57 430287 AW182459 Hs 125759 ESTs, Weakly similar to LEU5.HUMAN LEUKE 57
405238 Target Exon 57
432890 NM 014442 Hs 279751 sialic acid binding Ig-like lectin 8 57
440492 R39127 Hs 21433 hypothedcal protein DKFZp547J036 57
413492 D87470 Hs 75400 KIAA0280 protein 57
427624 AA406245 Hs 24895 ESTs 57
418079 R40058 Hs 6911 ESTs 56
424458 M29273 Hs 1780 myelin associated glycoprotein 56
448299 AA497044 Hs 20887 hypothedcal protein FU 10392 56
429698 AI685086 Hs 26339 ESTs, Weakly similar to S21348 probable 56
430228 AW950939 Hs 6382 ESTs, Highly similar to T00391 hypotheti 56
445255 NM 014841 Hs 12477 synaptosomal-associated protein, 91 kDa 56
436887 AW953157 Hs 193235 hypothedcal protein DKFZp547D155 56
452898 AA814497 Hs 78792 ESTs 56
435538 AB011540 HS 4930 low density lipoprotein receptor-related 56
436035 AA703679 Hs 106999 ESTs, Weakly similar to SYT5 HUMAN SYNAP 55
412190 R16180 Hs 274461 ESTs 55
459278 AW294659 Hs 34054 Homo sapiens cDNA FU22488 fis, clone H 55
416490 AF090116 Hs 79348 regulator of G-protem signalling 7 55
423449 AI497900 Hs 33067 ESTs 55
440866 AI703103 Hs 271360 hypothetical protein MGC16275 55
432154 AI701523 Hs 112577 ESTs 54
423476 AL035633 Human DNA sequence from clone RP5-1046G1 54
428588 F12101 Hs 185701 Homo sapiens mRNA full length insert cDN 54
447773 AI423930 Hs 36790 ESTs, Weakly similar to putadve p150 [H 54
436936 AL134451 Hs 197478 ESTs 54
427250 R35941 Hs 25418 ESTs 54
427302 AA400540 Hs 135282 Homo sapiens cDNA FU 11554 fis, clone HE 54
452856 AF034799 Hs 30881 protein tyrosine phosphatase, receptor t 54
428795 R45503 Hs 97469 ESTs, Highly similar to A39769 N-acetyll 54
407385 AA610150 Hs 272072 ESTs, Weakly similar to I38022 hypotheti 54
405348 C7001664 gι|12698061 |db||BAB21849 1| (AB 54
438330 AW450572 Hs 257316 ESTs 53
426503 AA380153 gb EST93093 Skin tumor I Homo sapiens cD 53
448148 NM 016578 Hs 20509 HBV pX associated proteιn-8 53
410386 W26187 Hs 3327 Homo sapiens cDNA FU22219 fis, clone H 53
445225 AI216555 Hs 202398 ESTs 53
428784 Y12851 Hs 193470 punnergic receptor P2X, ligand-gated 53
418759 AA227879 Hs 187621 ESTs 53
402605 Target Exon 53
412046 Y07847 Hs 73088 RAS-related on chromsome 22 53
423869 BE409301 Hs 134012 Clq-related factor 52
430130 AL137311 Hs 234074 Homo sapiens mRNA, cDNA DKFZp761G02121 ( 52
453096 AW294631 Hs 11325 ESTs 52
450475 AW805634 Hs 205015 ESTs 52
429139 F09092 Hs 66087 ESTs 52
451783 R42554 Hs 210862 T-box, brain 1 52
436568 H12049 Hs 91564 ESTs 52
424330 AW073953 Hs 333396 Homo sapiens cDNA FLJ 13596 fis, clone PL 52
408453 AI369838 Hs 45127 chondroitin sulfate proteoglycan 5 (πeur 52
447499 AW262580 Hs 147674 protocadhenn beta 16 52
402855 NM.001839* Homo sapiens calponin 3, acid 52
420805 L10333 Hs 99947 redculon 1 52
426457 AW894667 Hs 169965 chimeπn (chimaeπn) 1 52
417355 D13168 Hs 82002 endothelin receptor type B 5 1
429469 M64590 Hs 27 glycine dehydrogenase (decarboxyladng 5 1
450639 AI703186 Hs 277174 ESTs 51
412811 H06382 ESTs 51
400379 NM 018432 Homo sapiens ovanan cancer related prot 5 1
441869 NM 003947 Hs 8004 hundngtin-associated protein interactin 5 1
442832 AW206560 Hs 253569 ESTs 51
422709 AA315331 Hs 153485 ESTs 5 1
411555 AF113537 Hs 70669 HMP19 protein 51
419043 T19167 Hs 89566 ets vanant gene 1 50
430979 AI479755 Hs 129010 ESTs 50
451320 AW118072 diacylglycerol kinase, zeta (104kD) 50
423678 AW963357 Hs 7847 ESTs 50
429918 AW873986 Hs 119383 ESTs 50
452785 AL359942 Hs 296434 erythroid differentiation and denuclead 50
453128 AW026516 Hs 31791 acylphosphatase 2, muscle type 50
428001 H97428 Hs 219907 ESTs, Moderately similar to Transforming 50
430183 BE010038 gb PM3-BN0176-100400-001-g04 BN0176 Homo 50
449969 AW295142 Hs 180187 Homo sapiens cDNA FU14337 fis, clone PL 50
439108 AW163034 Hs 6467 synaptogyπn 3 50
426271 AF026547 Hs 169047 choπdroidn sulfate proteoglycan 3 (neur 50
451752 AB032997 Hs 26966 KIAA1171 protein 50
420578 AA813546 Hs 99034 GTP-binding protein Rho7 49
427315 AA179949 Hs 175563 Homo sapiens mRNA, cDNA DKFZp564N0763 (f 49
428186 AW504300 Hs 295605 mannosidase, alpha, class 2A, member 2 49
445133 AW157646 Hs 198689 ESTs 49
410359 R38624 Hs 106313 ESTs 49
427144 X95097 Hs 2126 vasoactive intestinal pepdde receptor 2 49
448548 R13209 Hs 21413 solute earner family 12, (potassium-chl 49 457561 AA331517 Hs 286055 chimeπn (chimaenn) 2 49
409100 H98216 Hs 42245 ESTs, Moderately similar to I38022 hypot 49
437117 AL049256 Hs 122593 ESTs 49
415101 R45531 Hs 144534 ESTs 49
438458 AW975186 gb EST387294 MAGE resequences, MAGN Homo 49
442026 AI243749 Hs 8074 brain specific angiogenesis inhibitor 3 49
438283 AI458931 Hs 37282 ESTs 49
449714 AB033015 Hs 23941 KIAA1189 protein 49
420871 AA702972 Hs 65300 ESTs 49
425256 BE297611 Hs 155392 collapsin response mediator protein 1 49
424001 W67883 Hs 137476 paternally expressed 10 49
419103 Z40229 Hs 96423 hypothetical protein FU23033 48
446727 AB011095 Hs 16032 KIAA0523 protein 48
408670 AF160967 Hs 46784 potassium large conductance calcium-acd 48
428189 AA424030 Hs 46627 ESTs 48
420092 AA81 043 Hs 88045 ESTs 48
410631 AA086469 Hs 47171 ESTs 48
449277 AA001064 Hs 43670 ESTs 48
436282 R91913 Hs 272104 ESTs, Moderately similar to ALU1.HUMAN A 48
414706 AW340125 Hs 76989 KIAA0O97 gene product 48
438703 AI803373 Hs 31599 ESTs 48
439340 AB032436 Hs 6535 brain-specific Na-dependent inorganic ph 48
445890 AF055019 Hs 21906 Homo sapiens clone 24670 mRNA sequence 47
436734 AI937612 Hs 273758 hypothetical protein FU23112 47
408177 AI241733 Hs 43871 ESTs 47
445740 T78281 Hs 13226 Homo sapiens clone 25181 mRNA sequence 47
459527 AW977556 Hs 291735 ESTs, Weakly similar to 178885 seππeΛh 47
445523 Z30118 Hs 293788 ESTs, Moderately similar to unnamed prot 47
409172 Z99399 Hs 122593 ESTs 47
437748 AF234882 Hs 5814 suppression of tumongemcity 7 47
421637 AF035290 Hs 106300 Homo sapiens clone 23556 mRNA sequence 47
448044 AI458682 gb tk13e01 x1 NCI_CGAP_Lu24 Homo sapiens 47
459311 R40192 Hs 21527 Human DNA sequence from clone GS1 -115M3 47
447891 R41754 Hs 6496 ESTs 47
426968 U07616 Hs 173034 amphiphysin (Stiff-Mann syndrome with br 4 7
404819 NM_002688* Homo sapiens peanut (Drosophi 47
409125 R17268 Hs 343567 axonal Uansport of synapdc vesicles 47
437762 T78028 Hs 154679 synaptotagmin I 47
441668 AI611973 Hs 136313 ESTs 47
444190 AI878918 Hs 10526 cysteme and glycine-nch protein 2 46
429269 AA449013 Hs 99203 ESTs 46
433009 AA761668 gb nz24c08 s1 NCI_CGAP_GCB1 Homo sapiens 46
416586 D44643 Hs 14144 secreted modular calcium-binding protein 46
427701 AA411101 Hs 243886 nuclear autoantigenic sperm protein (his 46
426925 NM 001196 Hs 315689 Homo sapiens cDNA FLJ22373 fis, clone H 46
410264 AK001853 Hs 61508 Homo sapiens cDNA FLJ10991 fis, clone PL 46
437698 R61837 Hs 7990 ESTs, Moderately similar to I84505 calci 46
445813 Z42023 Hs 106576 alanine-glyoxylate aminotransferase 2-lι 46
424264 D80400 Hs 239388 Human DNA sequence from clone RP1-304B14 46
448765 R15337 Hs 21958 Homo sapiens mRNA, cDNA DKFZp547D086 (fr 46
419723 AL120193 Hs 339810 longevity assurance (LAG1. S cerevisiae 46
424282 R76421 Hs 135694 ESTs 46
429401 AW296102 Hs 99272 ESTs, Weakly similar to S32567 A4 protei 46
426413 AA377823 gb EST90805 Synovial sarcoma Homo sapien 45
407896 D76435 Hs 41154 Zic family member 1 (odd-paired Drosophi 45
413248 T64858 Hs 21433 hypothetical protein DKFZp547J036 45
443731 AI083928 Hs 145418 ESTs 45
449539 W80363 Hs 58446 ESTs 45
420362 U79734 Hs 97206 hundngdn interacdng protem 1 45
443301 AI733614 Hs 220587 ESTs, Moderately similar to ALU5_HUMAN A 45
423178 AI033140 Hs 124983 Homo sapiens mRNA, cDNA DKFZp564C142 (fr 45
437933 AI276132 Hs 146155 ESTs 45
446544 AI631932 Hs 7047 ESTs, Weakly similar to Unknown [H sapie 45
411642 NM 014932 Hs 71132 neuroligm 1 45
428282 N34905 Hs 44653 Homo sapiens cDNA FLJ22669 fis, clone H 45
411498 NM 014210 Hs 70499 ecotropic viral integradon site 2A 45
408622 AA056060 Hs 202577 Homo sapiens cDNA FU12166 fis, clone MA 45
436637 AI783629 Hs 26766 ESTs 45
438456 AA913381 Hs 20594 ESTs 45
400533 ENSP00000209376* PRED65 protein (Fragmen 44
413951 AW051200 Hs 75640 natπuredc pepdde precursor A 44
417632 R20855 Hs 5422 glycoprotein M6B 44
425138 H08849 Hs 167464 glutamate receptor, -onotropic, N-methyl 44
457211 AW972565 Hs 32399 ESTs, Weakly similar to S51797 vasodilat 44
413812 AW188687 Hs 44748 ESTs 44
448451 AW015994 Hs 345433 gb Ul H-BIOp-abh-g-09 -UI s1 NCI.CGAP.S 44
432281 AK001239 Hs 274263 hypothetical protein FU10377 44
458760 AI498631 Hs 111334 femdn, light polypeptide 44
405819 NM 002578 Homo sapiens p21 (CDKNIA)-acd 44
447877 AI435184 Hs 164252 ESTs 44
431342 AW971018 Hs 21659 ESTs 44
408577 H50572 Hs 19515 ESTs, Highly similar to NRG3.HUMAN PRO-N 44
445729 H21066 Hs 13223 Homo sapiens mRNA full length insert cDN 44 422253 W81526 Hs 118329 ESTs, Moderately similar to GAD.HUMAN GA 44
419088 AI538323 Hs 52620 integπn, beta 8 44
428305 AA446628 Hs 2799 cartilage linking protein 1 44
410768 AF038185 Hs 66187 Homo sapiens clone 23700 mRNA sequence 44
428722 U76456 Hs 190787 dssue inhibitor of metalloproteinase 4 44
451621 AI879148 Hs 26770 fatty acid binding protein 7, brain 44
424240 AB023185 Hs 143535 calcium/calmodulin-dependent protein k 43
433932 AW954599 Hs 169330 neuronal protein 43
439935 S75105 Hs 8358 glutamate receptor, lonotropic, kainate 43
436039 AW023323 Hs 121070 ESTs 43
416220 N49776 Hs 170994 hypothetical protein MGC10946 43
409953 AA332277 Hs 57691 cadheπn 18, type 2 43
456497 AW967956 Hs 123648 ESTs, Weakly similar to AF108460 1 ubiπu 43
420352 BE258835 gb 601117374F1 NIH.MGC.16 Homo sapiens c 43
454032 W31790 Hs 194293 ESTs, Weakly similar to I54374 gene NF2 43
421790 AW896201 Hs 22654 sodium channel, voltage-gated, type I, a 43
444218 AF070641 Hs 10684 Homo sapiens clone 24421 mRNA sequence 43
436391 AJ227892 Hs 146274 ESTs 43
452106 AI141031 Hs 21342 ESTs 43
422465 AF073710 Hs 117149 regulator of G-protem signalling 9 43
439285 AL133916 hypothetical protein FU20093 43
404541 NM_030795 Homo sapiens stathmin-like 4 ( 43
424572 M19650 2\3'-cyclιc nucleodde 31 phosphodieste 43
449048 Z45051 Hs 22920 similar to S68401 (cattle) glucose indue 43
409182 AA064970 Hs 122593 ESTs 43
444600 R41398 Hs 6996 ESTs 43
408838 AI669535 Hs 40369 ESTs 43
410592 R94088 Hs 43569 ESTs 43
440168 AA868507 Hs 126141 ESTs 42
445078 AI869975 Hs 4775 junctophilin 3 42
428670 AA431682 Hs 134832 ESTs 42
411666 AF106564 Hs 71346 neurofilament 3 (150kD medium) 42
412505 AA974491 Hs 21734 ESTs 42
418506 AA084248 Hs 85339 G protein-coupled receptor 39 42
441707 R42637 Hs 21963 hypothedcal protein DKFZp761B0514 42
449433 AI672096 Hs 9012 ESTs, Weakly similar to S26650 DNA-bmdi 42
441523 AW514263 Hs 301771 ESTs, Weakly similar to ALUF.HUMAN "" 42
448243 AW369771 Hs 52620 integnn, beta 8 42
429149 AW193360 Hs 197962 ESTs, Weakly similar to I38022 hypothed 42
430676 AF084866 gb Homo sapiens envelope protein RIC-3 ( 42
404584 Target Exon 42
422798 R92347 Hs 34574 ESTs, Weakly similar to ALU1.HUMAN ALU S 42
451254 AI571016 Hs 172967 ESTs 42
428585 AB007863 Hs 185140 KIAA0403 protein 42
439231 AW581935 Hs 141480 Homo sapiens mRNA, cDNA DKFZp434N079 (fr 42
425287 R88249 Hs 155524 peanut (Drosophila) like 2 42
425790 AW136286 Hs 288446 ESTs 42
450407 NM 000810 Hs 24969 gamma-aminobutync acid (GABA) A recepto 42
425241 AA324624 Hs 155247 aldolase C, fructose bisphosphate 42
445292 AV653264 Hs 13982 Homo sapiens cDNA FLJ 14666 fis, clone NT 4 1
400777 NM.007325' Homo sapiens glutamate recept 41
422170 AI791949 Hs 112432 and-Mulleπan hormone 4 1
410765 AI694972 Hs 66180 nucleosome assembly protein 1 -like 2 4 1
425402 AI215881 Hs 24970 ESTs, Weakly similar to B34323 GTP-bindi 4 1
438461 AW075485 Hs 286049 phosphoseπne aminotransferase 4 1
421268 AI126821 Hs 30514 ESTs 4 1
416439 AA180363 Hs 118769 ESTs 41
419687 AI638859 Hs 227699 ESTs, Weakly similar to T2D3 HUMAN TRANS 4 1
435040 AI932350 Hs 152825 ESTs 41
439774 AL360257 Hs 213493 Homo sapiens mRNA full length insert cDN 4 1
458435 AI418718 Hs 144121 ESTs, Weakly similar to T46916 hypothed 41
410320 AA084071 Hs 93816 Homo sapiens mRNA, cDNA DKFZp547N093 (fr 4 1
436899 AA764852 Hs 291567 ESTs 4 1
454171 AW854832 gb QV2-CT0261-201099-011-f05 CT0261 Homo 41
453118 AW195849 Hs 252757 ESTs 4 1
428771 AB028992 Hs 193143 KIAA1069 protein 4 1
444185 AW298350 Hs 66020 ESTs 4 1
422374 AW732869 Hs 1519 protein kinase, cAMP-dependent, regulato 4 1
430147 R60704 Hs 234434 haiiγ/enhancer-of-split related with YRP 4 1
456060 C1 904 Hs 45184 Homo sapiens cDNA FU 12284 fis, clone MA 4 1
433819 AW511097 Hs 112765 ESTs 4 1
415827 H17462 Hs 23079 ESTs 4 1
437397 AA349847 Hs 4221 hypothedcal protem DKFZp761H039 4 1
441390 AI692560 Hs 131175 ESTs 4 1
440483 AI200836 Hs 150386 ESTs 40
435294 T84084 Hs 196008 Homo sapiens cDNA FU 11723 fis clone HE 40
447397 BE247676 Hs 18442 E-1 enzyme 40
425390 AI092634 Hs 156114 protein tyrosine phosphatase, non recept 40
432022 AL162042 Hs 272348 Homo sapiens mRNA, cDNA OKFZp761L1212 (f 40
420602 AF060877 Hs 99236 regulator of G-protem signalling 20 40
408081 AW451597 Hs 167409 ESTs 40
453313 BE005771 Hs 153746 hypothedcal protein FU22490 40
436511 AA721252 Hs 291502 ESTs 40 448944 AB014605 Hs 22599 atrophιn-1 mteracdng protein 1, acdvi 40
419412 AW161058 Hs 90297 synudein. beta 40
409091 AW970386 Hs 269423 ESTs 40
453438 AI469935 Hs 22792 ESTs 40
450582 AI339732 G-nch RNA sequence binding factor 1 40
440553 AA889416 Hs 344043 Homo sapiens cDNA FU14459 fis, clone HE 40
437449 AL390153 Hs 208339 Homo sapiens mRNA, cDNA DKFZp762G113 (fr 40
445888 AF070564 Hs 13415 Homo sapiens clone 24571 mRNA sequence 40
439450 R51613 Hs 125304 ESTs 40
453792 AL134539 Hs 254129 KIAA1678 40
459080 AW192083 Hs 290855 ESTs 40
438810 AW897846 Hs 6421 hypothedcal protein DKFZp761N09121 40
446233 AI282028 Hs 25205 ESTs 40
412754 AW160375 Hs 74565 amyloid beta (A4) precursor-like protein 40
412326 R07566 Hs 73817 small inducible cytokine A3 (homologous 40
434859 BE255080 Hs 299315 collapsin response mediator proteιn-5. C 40
423279 AW959861 Hs 290943 ESTs 40
416340 N31772 Hs 79226 fasciculation and elongation protein zet 39
410126 BE169274 KIAA0036 gene produd 39
431173 AW971198 Hs 294068 ESTs 39
446936 H10207 Hs 47314 ESTs 39
424899 AL119387 Hs 119062 ESTs 39
419038 AW134924 Hs 190325 ESTs 39
450530 NM 006668 Hs 25121 cytochrome P450, subfamily 46 (chdester 39
438142 T90309 Hs 269651 ESTs 39
412659 AW753865 Hs 74376 olfactomedin related ER localized protei 39
412788 AA120960 Hs 198416 ESTs 39
410909 AW898161 Hs 53112 ESTs, Moderately similar to ALU8.HUMAN A 39
429433 AA452899 Hs 213586 ESTs, Weakly similar to KIAA1353 protein 39
432809 AA565509 Hs 131703 ESTs 39
424186 AI536021 Hs 288706 Homo sapiens cDNA FU10281 fis, clone HE 39
425480 AB023198 Hs 158135 KIAA0981 protem 39
449932 AI675444 Hs 263024 ESTs 39
434072 H70854 Hs 283059 Homo sapiens PRO1082 mRNA, complete eds 39
450590 AI701507 Hs 273740 ESTs 39
419586 AI088485 Hs 144759 ESTs, Weakly similar to I38022 hypothed 39
414040 N58513 Hs 32171 ESTs 39
436480 AJ271643 Hs 87469 putative acid-sensing -on channel 39
443210 AI692649 Hs 9451 hypothedcal protein MGC13168 39
448448 NM 014954 Hs 21239 KIAA0985 protein 39
447067 R42098 Hs 21964 ESTs 39
413199 M62843 Hs 75236 ELAV (embryonic lethal, abnormal vision, 39
429421 AL031658 Human DNA sequence from clone RP1-310O13 39
415796 R87548 Hs 78854 ATPase Na' transporting beta 2 polypep 38
417333 AL157545 Hs 173179 bromodomam and PHD finger containing 3 38
418771 AA807881 Hs 25329 ESTs 38
417565 AI203405 Hs 47831 ESTs 38
412420 AL035668 Hs 73853 bone morphogenedc protein 2 38
450202 AW969756 Hs 34145 ESTs, Weakly similar to B49647 GTP-bindi 38
435312 AJ243396 Hs 4865 voltage-gated sodium channel beta-3 subu 38
435832 AA425688 Hs 41641 Bruno (Drosophila) -like 4, RNA binding 38
435854 AJ278120 Hs 4996 putative ankyπn repeat contan g prote 38
459079 AI821122 gb ns91g10 y5 NCI_CGAP_Pr3 Homo sapiens 38
425905 AB032959 Hs 318584 novel C3HC4 type Zinc finger (πng finge 38
421977 W94197 Hs 110165 πbosomal protein L26 homolog 38
437756 AA767537 Hs 197096 ESTs 38
403696 C4001100" gι|5852342|gb|AAD54015 1| (AF0 38
453033 AA325869 Hs 31463 KIAA0281 gene product 38
441732 AW298818 Hs 127341 ESTs 38
415884 H22966 Hs 13471 ESTs 38
432646 AW753310 gb RC3-CT0254-031099-012-C05 CT0254 Homo 38
451059 AW297465 Hs 267150 KIAA1409 protein 38
447057 AI423407 Hs 157697 ESTs 38
418915 AI474778 Hs 118977 ESTs 38
441111 AI806867 Hs 126594 ESTs 38
447818 W79940 Hs 21906 Homo sapiens clone 24670 mRNA sequence 38
457183 H91882 Hs 118569 Dvl binding protein IDAX (inhibition of 38
418358 L02840 Hs 84244 potassium voltage-gated channel, Shab-re 38
410711 AB0O2316 Hs 65746 KIAA0318 protein 38
428878 AA436884 Hs 48926 ESTs 38
438944 AA302517 Hs 92732 KIAA1444 protein 38
420898 AB002379 Hs 100113 KIAA0381 protein 38
418329 AW247430 Hs 84152 cystathionine-beta-synthase 38
427209 H06509 Hs 92423 KIAA1566 protein 37
445319 AF052108 Hs 12513 Homo sapiens clone 23687 mRNA sequence 37
428841 AI418430 Hs 104935 ESTs 37
414821 M63835 Hs 77424 Fc fragment of IgG. high affinity la, re 37
443310 BE552018 Hs 133152 ESTs 37
407728 AW071502 Hs 175931 ESTs 37
429643 AA455889 Hs 167279 FYVE-finger-containing Rab5 effector pro 37
444127 N63620 Hs 13281 ESTs 37
425652 AB021742 Hs 322431 neurogenic differendadon 2 37
458072 AI890347 Hs 271923 Homo sapiens cDNA FU22785 fis clone K 37 459660 M79082 ESTs 37
432188 AI362952 Hs 2928 solute earner family 7 (cationic ammo 37
437627 AW469925 Hs 257837 ESTs 37
408508 AI806109 Hs 135736 KIAA1580 protein 37
448999 AF179274 Hs 22791 transmembrane protein with EGF-like and 37
410623 AW958932 Hs 293833 ESTs 37
430744 AA485229 Hs 105649 ESTs 37
454392 BE260893 Hs 236131 homeodomam-interacdng protein kinase 2 37
453739 AL120266 ESTs 37
407198 H91679 gb yv04a07 s1 Soares fetal liver spleen 37
405239 U89281 oxidadve 3 alpha hydroxysteroid dehydro 37
433615 AA732982 Hs 269607 ESTs, Weakly similar to ALU1.HUMAN ALU S 37
424800 AL035588 Hs 153203 MyoD family inhibitor 37
451027 AW519204 Hs 40808 ESTs 37
415131 D61119 gb HUM158C11 B Clontech human fetal brain 37
443454 AI057494 Hs 133421 ESTs 37
423779 AW071837 Hs 57971 ESTs 37
452092 BE245374 Hs 27842 hypothedcal protein FU11210 37
435910 AI084152 Hs 21782 ESTs, Weakly similar to ALU7.HUMAN ALU S 36
447028 AI973128 Hs 167257 brain link proteιn-1 36
452997 N64777 Hs 44656 ESTs 36
408601 U47928 Hs 86122 protein A 36
407332 AI801565 Hs 200113 Homo sapiens cDNA FU 11379 fis, clone HE 36
455646 BE064420 gb RC4-BT0311-241199-012-c08 BT0311 Homo 36
433657 AI244368 Hs 8124 PH domain containing protein in redna 1 36
421679 AI475110 Hs 203933 ESTs 36
448985 AA324885 Hs 22777 carbonic anhydrase XI 36
414709 AA704703 Hs 77031 Sp2 transcnpdon factor 36
411775 H08342 gb yl87b09 r1 Soares infant brain 1NIB H 36
439099 AB037800 Hs 6462 protein kinase C and casein kinase subst 36
436315 BE390513 Hs 27935 hypothedcal protein MGC4837 36
423611 AB011163 Hs 129908 KIAA0591 protein 36
453169 AB037815 Hs 32156 KIAA1394 protein 36
436954 AA740151 Hs 130425 ESTs 36
439249 AF086060 Hs 170053 G protein coupled receptor 88 36
432058 AW665996 Hs 130729 ESTs Weakly similar to ALU1.HUMAN ALU S 36
419390 AI701162 Hs 90207 hypothetical protein MGC11138 36
428483 AI908539 Hs 184592 KIAA0344 gene product 36
409557 BE182896 Hs 211193 ESTs 36
418049 AA211467 Hs 190488 Homo sapiens Similar to nuclear lccaliz 36
443774 AL117428 Hs 9740 DKFZP434A236 protein 36
425331 AW962128 gb EST374201 MAGE resequences, MAGG Homo 36
445105 AF238869 Hs 283955 Homo sapiens clone GLSH-2 similar to gli 36
424051 AL110203 Hs 138411 Homo sapiens mRNA, cDNA DKFZp586J1922 (f 36
446420 AW015693 Hs 135614 ESTs 36
428138 AA773842 Hs 293799 ESTs 36
404185 Target Exon 36
427517 AA644142 Hs 7107 ESTs. Weakly similar to ALU7 HUMAN ALU S 36
443150 AI034467 Hs 34650 ESTs 36
408065 AW954272 gb EST366342 MAGE resequences, MAGC Homo 36
435092 AL137310 Hs 4749 Homo sapiens mRNA, cDNA DKFZp761E13121 ( 36
418064 BE387287 Hs 83384 S100 calcium binding protein, beta (neur 36
433560 AI925195 Hs 130891 hypothetical protein MGC4400 36
432882 NM 013257 Hs 279696 serum/glucocorticoid regulated k ase-li 36
412350 AI659306 Hs 73826 protein tyrosine phosphatase, non-recept 36
439753 BE262233 Hs 7423 hypothetical protein from EUROIMAGE 2168 36
451734 NM 006176 Hs 26944 neurogranin (protein kinase C substrate, 36
437056 AI147061 gb ok33a11 s1 Soares NSF F8 9W OT PA P S 36
438328 AI492261 Hs 32450 ESTs 36
451489 NM 005503 Hs 26468 amyloid beta (A4) precursor protein-bind 36
423641 AL137256 Hs 130489 ATPase ammophospholipid transporter-d 36
434784 AA649051 Hs 164007 ESTs 35
441834 AL138034 Hs 7979 KIAA0736 gene product 35
421183 AL135740 Hs 102447 TSC-22-hke 35
452108 AW135982 Hs 203013 hypothetical protein FU 12748 35
425870 R13406 Hs 56782 ESTs 35
425115 R44664 Hs 123956 ESTs 35
444471 AB020684 Hs 11217 KIAA0877 protein 35
419929 U90268 Hs 93810 cerebral cavernous malformations 1 35
407792 AI077715 Hs 39384 putative secreted ligand homologous to f 35
422564 AI148006 Hs 222120 ESTs 35
433323 AA805132 Hs 159142 ESTs 35
435743 T66861 Hs 12962 ESTs 35
450297 AW901347 Hs 38592 hypothetical protein FU23342 35
403341 Target Exon 35
443761 AI525743 Hs 345187 ESTs 35
458743 R53169 Hs 80712 KIAA0202 protein 35
447925 AW292271 Hs 250718 ESTs 35
445424 AB028945 Hs 12696 cortacdn SH3 domain-binding protein 35
416874 H98752 Hs 42568 ESTs 35
430456 AA31 998 Hs 241503 hypothetical protein 35
419647 AA348947 HS 91816 hypothetical protein 35
412707 AW206373 Hs 16443 Homo sapiens cDNA FU21721 fis clone C 35 444458 BE041526 Hs 31746 hypothedcal protein DKFZp547F072 35
451066 AI758660 Hs 206132 ESTs 35
425234 AW152225 Hs 165909 ESTs, Weakly similar to I38022 hypothed 35
420071 AB028985 Hs 94806 ATP-bindmg cassette, sub-family A (ABC1 35
432625 AI243596 Hs 94830 ESTs, Moderately similar to T03094 A-kiπ 35
442118 AA976718 Hs 202242 ESTs 35
421686 AB011156 Hs 106794 KIAA0584 protein 35
428966 AF059214 Hs 194687 cholesterol 25-hydroxylase 35
444326 AI939357 Hs 270710 ESTs 35
443361 AI792628 Hs 133273 ESTs 35
427627 R87582 Hs 179915 guanine nucleotide binding protein (G pr 34
434542 AA769310 Hs 61260 hypothedcal protein FLJ13164 34
419235 AW470411 Hs 288433 neurotπmm 34
440700 AW952281 Hs 296184 guanine nucleotide binding protein (G pr 34
417084 H08370 Hs 33067 ESTs 34
432925 AA878324 ESTs 34
439920 H05430 Hs 288433 neurotπmiπ 34
453710 AL119136 Hs 236131 homeodomam-interacdng protein kinase 2 34
412783 BE276738 Hs 74578 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 34
435977 AL138079 Hs 5012 brain-specific membrane-anchored protein 34
431725 X65724 Hs 2839 Nome disease (pseudoglioma) 34
449611 AI970394 Hs 197075 ESTs 34
448543 AW897741 Hs 21380 Homo sapiens mRNA, cDNA DKFZp586P1124 (f 34
430968 AW972830 gb EST384925 MAGE resequences, MAGL Homo 34
413530 AA130158 Hs 19977 ESTs, Moderately similar to ALU8.HUMAN A 34
412043 BE156622 Hs 333371 Homo sapiens done TA40 untranslated mRN 34
445666 R59960 Hs 282386 ESTs 34
412820 BE001236 gb CM3-BN0075-240200-101-d11 BN0O75 Homo 34
458912 AI911066 ESTs 34
452449 AW068658 Hs 20943 ESTs 34
437085 AA743935 Hs 202329 ESTs 34
419852 AW503756 Hs 286184 hypothetical protein dJ551D25 34
448750 U95020 Hs 21903 calcium channel, voltage-dependent, beta 34
435741 AI240668 Hs 113099 ESTs 34
445828 F05802 Hs 81907 ESTs 34
419347 C15944 Hs 90005 supenorcervical ganglia neural specifi 34
431733 AW298410 Hs 21475 ESTs 34
415949 H10562 Hs 21691 ESTs 34
400205 NM.006265" Homo sapiens RAD21 (S pombe) 34
437528 N59646 Hs 169745 crumbs (Drosophila) homolog 1 34
442593 R39804 Hs 31961 ESTs 34
442927 AI024347 Hs 131519 ESTs 34
429528 AI985303 Hs 99361 ESTs 34
450756 AI733488 Hs 144062 ESTs 34
437387 AI198874 Hs 28847 AD026 protein 34
430347 NM.002039 Hs 239706 GRB2-assocιated binding protein 1 34
404283 ENSP00000244751" Copiπe-dke protein KIA 34
433229 AB040925 Hs 91625 KIAA1492 protein 34
440274 R24595 Hs 7122 scrapie responsive protein 1 34
436114 AA778232 Hs 19515 ESTs, Highly similar to NRG3 HUMAN PRO-N 34
439690 AA843868 Hs 190567 ESTs 34
450784 AW246803 Hs 47289 ESTs 33
417868 AI078534 Hs 122592 ESTs 33
439793 AA018825 Hs 7934 Kruppel-like factor 4 (gut) 33
456209 W60633 Hs 297792 ESTs 33
421458 NM 003654 Hs 104576 carbohydrate (keratan sulfate Gal-6) sul 33
438201 AA780243 Hs 54647 ESTs 33
400302 N48056 Hs 1915 folate hydrolase (prostate specific memb 33
425897 AA935315 Hs 48965 Homo sapiens cDNA FU21693 fis, clone C 33
423169 BE047009 Hs 21837 ESTs, Weakly similar to KIAA0927 protein 33
415539 AI733881 Hs 72472 BMP-R1B 33
450337 AI693256 Hs 202427 ESTs 33
408447 AK002089 Hs 45080 Homo sapiens cDNA FU11227 fis, clone PL 33
423420 AI571364 Hs 128382 Homo sapiens mRNA, cDNA DKFZp761l1224 (f 33
429084 AJ001443 Hs 195614 splicing factor 3b, subunit 3, 130kD 33
440435 AL042201 Hs 21273 transcnpdon factor NYD-sp10 33
453785 AI368236 Hs 283732 ESTs, Moderately similar to ALU1.HUMAN A 33
448048 BE281291 Hs 170408 ESTs, Moderately similar to A47582 B-cel 33
436207 AA334774 Hs 12845 hypothetical protein MGC13159 33
404632 NM 022490 Homo sapiens hypothedcal prot 33
411565 AW851728 gb MR2-CT0222-O11199-0O7-d06 CT0222 Homo 33
416845 H95279 Hs 293788 gb yu20h02 s1 Soares fetal liver spleen 33
436267 AW450938 Hs 180115 ESTs 33
426625 T78300 Hs 300642 serologically defined colon cancer andg 33
401272 C9000559" gι|12314195|emb|CAB99338 1| (A 33
435071 D60683 Hs 35495 ESTs 33
433128 AB021923 Hs 23367 EST-YD1 protein 33
426920 AA393351 Hs 132121 ESTs 33
423668 Y10148 Hs 131138 neurotensin receptor 2 33
435056 AW023337 Hs 5422 glycoprotein M6B 33
445534 AL038823 Hs 12840 Homo sapiens germline mRNA sequence 33
425010 T16837 Hs 4241 ESTs 33
445260 AI218133 Hs 147617 ESTs 33 421094 AW978202 Hs 289064 hypothedcal protein FU22251 33
450358 AB010098 Hs 24907 coroπm. acdn-binding protein, 2B 33
411048 AK001742 Hs 67991 hypothedcal protein DKFZp434G0522 33
432488 AA551010 Hs 216640 ESTs 33
443672 AA323362 Hs 9667 butyrobetaine (gamma), 2-oxoglutarate di 33
412719 AW016610 Hs 816 ESTs 33
420050 AL118615 Hs 94653 neurochondπn 33
410082 AA081594 Hs 158311 Musashi (Drosophila) homolog 1 33
408554 AA836381 Hs 315111 nuclear receptor co-repressor/HDAC3 comp 33
431462 AW583672 Hs 256311 granm like neuroendocnne peptide precu 32
434574 AI424458 Hs 33470 ESTs 32
432715 AA247152 Hs 200483 ESTs, Weakly similar to KIAA1074 protein 32
426757 AW205640 Hs 158206 ESTs 32
428167 AA770021 Hs 16332 ESTs 32
451597 AW295250 Hs 207536 ESTs 32
400362 AF068294 Hs 272414 Homo sapiens HDCMB45P mRNA, partial eds 32
417675 AI808607 Hs 3781 similar to muπne leucine-nch repeat pr 32
429550 AW293055 Hs 119357 ESTs 32
404120 C5000537* gι|3298595|gb|AAC41376 1| (AF0 32
417123 BE326521 Hs 159450 ESTs 32
450313 AI038989 Hs 332633 Bardet-Biedl syndrome 2 32
425999 AW513051 Hs 332981 ESTs, Weakly similar to I38022 hypothed 32
430526 AF181862 Hs 242407 G protein-coupled receptor, family C, gr 32
452619 AW298597 Hs 61884 Homo sapiens, clone IMAGE 4298026, mRNA, 32
415558 AA885143 Hs 125719 ESTs 32
451996 AW514021 Hs 245510 ESTs 32
420560 AW207748 Hs 59115 ESTs 32
432328 AI572739 Hs 195471 6-phosphofructo-2-kinase/fructose-2,6-bi 32
417404 NM.007350 Hs 82101 pleckstπn homology-like domain, family 32
414300 AI304870 Hs 188680 ESTs 32
437834 AA769294 Hs 283854 gb nz36g03 s1 NCI CGAP GCB1 Homo sapiens 32
430694 AA810624 Hs 30936 ESTs, Weakly similar to H2BH HUMAN HISTO 32
447714 AW296313 Hs 255537 ESTs 32
412021 AW885592 gb RC4-OT0071-090300-011-g11 OT0071 Homo 32
443431 AI056847 Hs 20654 ESTs 32
445774 AI254165 Hs 339968 ESTs 32
431327 AW972220 Hs 105426 ESTs 32
413335 AI613318 Hs 48442 ESTs 32
430809 AI791150 Hs 262009 ESTs, Moderately similar to I38022 hypot 32
445858 AL133811 solute earner family 1 (glial high affi 32
450692 H50603 Hs 94037 hypothedcal protein FLJ23053 32
439039 AI656707 Hs 48713 ESTs 32
401720 NM_01 587" Homo sapiens SRY (sex determi 32
453740 AL120295 Hs 311809 ESTs, Moderately similar to PC4259 fem 32
451032 W03692 Hs 323079 Homo sapiens mRNA, cDNA DKFZp564P116 (fr 32
413834 BE296896 Hs 224179 ESTs, Weakly similar to I38022 hypothed 32
438138 R98299 Hs 177502 ESTs 32
436338 W92147 Hs 118394 ESTs 32
417169 R13550 Hs 246773 ESTs 32
424066 Z99348 Hs 112461 ESTs, Weakly similar to I38022 hypotheti 32
435767 H73505 Hs 117874 ESTs 32
415314 N88802 Hs 5422 glycoprotein M6B 32
448475 BE613134 Hs 247474 hypothedcal protein FU21032 32
414699 AI815523 Hs 76930 synuclein, alpha (non A4 component of am 32
438549 BE386801 Hs 21858 tnnucleotide repeat containing 3 32
453896 AW293483 Hs 255205 KIAA1853 protein 32
419539 AF070590 Hs 90869 Homo sapiens clones 24622 and 24623 mRNA 31
428832 AA578229 Hs 324239 ESTs, Moderately similar to ZN91.HUMAN Z 3 1
446636 AC002563 Hs 15767 citron (rho-interacdng, seπne/threonin 3 1
429046 X57436 Hs 194772 oligodendrocyte myelin glycoprotein 31
421896 N62293 Hs 45107 ESTs 3 1
413995 BE048146 Hs 75671 syntaxin 1A (brain) 3 1
414734 AA151712 Hs 82572 ESTs 31
446147 AL133064 Hs 14051 Homo sapiens mRNA, cDNA DKFZp434A2417 (f 3 1
427712 AI368024 Hs 283696 ESTs 3 1
406481 Target Exon 31
453204 R10799 Hs 191990 ESTs 3 1
422890 Z43784 ankyπn 3, node of Ranvier (ankyπn G) 3 1
422991 H10940 Hs 48965 Homo sapiens cDNA FU21693 fis, clone C 31
421030 AW161357 microtubule-associated protein tau 3 1
423603 AB0O7880 Hs 129883 Homo sapiens KIAA0420 mRNA, complete eds 3 1
413985 AI018666 Hs 75667 synaptophysin 3 1
431721 AB032996 Hs 268044 KIAA1170 protein 3 1
434164 AW207019 Hs 148135 seπne/threonme kinase 33 3 1
429876 AB028977 Hs 225974 KIAA1054 protein 3 1
423175 W27595 Hs 347310 hypothedcal protein FU 14627 3 1
412799 AI267606 gb aq91h03 x1 Stanley Frontal SB pool 1 3 1
459318 NM 000038 gb Homo sapiens adenomatosis polyposis c 3 1
453324 W26592 Hs 232089 ESTs 3 1
424009 F11690 gb HSC30D041 normalized infant brain cDN 3 1
436222 AI208737 Hs 122810 Homo sapiens cDNA FU11489 fis, clone HE 3 1
414884 R54418 Hs 183745 hypothedcal protein FU13456 31
446862 AV660697 Hs 282700 ESTs 3 1 427241 AA399988 Hs 112087 Human DNA sequence from clone RP11-530N1 3 1
455388 AW936234 gb QVO-DT0020-090200-106-g05 DT0020 Homo 3 1
415838 R44336 Hs 7093 ESTs 3 1
451692 AL137422 Hs 26849 Homo sapiens mRNA, cDNA DKFZp761A1623 (f 3 1
445294 Z45978 Human clone 23826 mRNA sequence 3 1
434460 AA478486 Hs 3852 KIAA0368 protein 3 1
449919 AI674685 Hs 200141 ESTs 3 1
440688 AW404591 Hs 147440 ESTs, Weakly similar to Z192.HUMAN ZINC 3 1
416801 X98834 Hs 79971 sal (Drosophιla)-lιke 2 3 1
428060 AA420616 Hs 249483 ESTs 3 1
423597 AL043117 Hs 129872 sperm associated andgen 9 3 1
452454 AW820480 gb QV2-ST0298-140200-042-f10 ST0298 Homo 3 1
445337 NM 013280 Hs 12523 fibronectin leucine πch transmembrane p 3 1
413974 BE208636 Hs 27788 ESTs 3 1
422772 AL119585 Hs 120228 KIAA0749 protein 3 1
423872 AB020316 Hs 134015 uronyl 2-sulfotransferase 3 1
435375 AI733610 Hs 187832 ESTs 3 1
450661 AW952160 Hs 83849 ESTs 3 1
428647 AA830050 Hs 124344 ESTs 3 1
400658 ENSP00000237081" KIAA1217 PROTEIN (FRAGM 30
443845 AI590084 Hs 148485 ESTs. Weakly similar to A47161 Mac-2-bιn 30
446619 AU076643 Hs 313 secreted phosphoprotein 1 (osteopondn, 30
433980 AA137152 Hs 286049 phosphoseππe aminotransferase 30
437738 AA766914 Hs 203475 ESTs, Weakly similar to ALU1 HUMAN ALU S 30
444772 AW450800 Hs 176859 ESTs 30
453825 AL157475 Hs 35453 Homo sapiens mRNA, cDNA DKFZp761G151 (fr 30
439971 W32474 Hs 301746 FΪAP2A, member of RAS oncogene family 30
408449 NM 004408 Hs 166161 dyna in 1 30
432821 BE170702 Hs 279005 solute earner family 21 (organic anion 30
453657 W23237 Hs 296162 AD037 protein 30
407235 D20569 Hs 169407 SAC2 (suppressor of acdπ mutations 2, y 30
428862 NM 000346 Hs 2316 SRY (sex determining region Y)-box 9 (ca 30
424726 AK0 1007 Hs 138760 Homo sapiens cDNA FU10145 fis, clone HE 30
454253 AV660717 Hs 47144 DKFZP586N0819 protein 30
450650 T65617 Hs 101257 hypothedcal protein MGC3295 30
418211 BE244746 Hs 247474 hypothedcal protein FU21032 30
440461 R52728 Hs 7193 KIAA1183 protein 30
452850 H23230 Hs 22481 ESTs, Moderately similar to A46010 X-lin 30
431431 AL096711 Hs 252953 Human DNA sequence from clone RP3-403A15 30
447881 BE620886 Hs 75354 GCN1 (general control of amino-acid synt 30
454042 H22570 hypothetical protein FU20093 30
429168 AA984682 Hs 146589 ESTs, Weakly similar to JC5238 galactosy 30
451391 AA017410 Hs 40568 ESTs 30
446377 AW014022 Hs 170953 ESTs 30
430251 AA609246 Hs 181451 ESTs 30
420658 AW965215 Hs 130707 ESTs 30
454119 BE549773 Hs 40510 uncoupling protein 4 30
451018 AW965599 Hs 247324 mitochondnal πbosomal protein S14 30
435321 R16814 Hs 112062 ESTs 30
412494 AL133900 Hs 792 ADP-nbosyladoπ factor domain protein 1 30
423858 AL137326 Hs 133483 Homo sapiens mRNA cDNA DKFZp434B0650 (f 30
431242 AA987742 Hs 347534 KIAA1201 protein 30
403022 C21000178" gι|7341207|gb|AAF61215 1|AF22 30
445899 AI263736 Hs 145626 ESTs 30
440261 M81886 HS 7117 glutamate receptor, loπotropic, AMPA 1 30
446809 AW590171 Hs 101413 ESTs 30
434269 AK001991 Hs 3781 similar to muπne leucine-nch repeat pr 30
418951 F07809 Hs 89506 paired box gene 6 (anmdia, keradds) 30
448499 BE613280 Hs 77550 hypothetical protein MGC1780 30
432229 AW290976 Hs 143587 ESTs 30
443726 AI083825 Hs 148382 ESTs 30
TABLE 13B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
408065 103646 1 AW954272 AI003154 AA059300 AA046911
410099 117647.1 AA081630 T08671 AI174254 D83874 AW959843 AA364503 AA693467 AW993370 BE327037 AA167714 N79906 AW901977 AW901980 W52882 T07735 AA484549 W60090 D52685 T23811 BE327043 AW901768 BE551237 AA917004 AA716027 AI439658 AA283724 AI805992 AI457096 AA084618 BE467736 AI092635 AI887863 AI697593 AA436618 AI167419 AI418634 T31586 AA436630 AA706191 AI041169 AI422304 T03534 AA211402 AI204899 AI366472 AW827081 AA788593 T32736 AI767935 AA167791 AA747914 AA663870 AI865504
410126 117761.1 BE169274 AW893230 AA210998 H24222 AA081774 BE000935 BE000834 AA334880 411565 1249756.1 AW851728 AW851607 AW851621 AW851702 AW851647 AW851727 AW851658 AW851617 AW851628 411775 125757.1 H08342 R52430 Z42067 AA095285 412021 1272156.1 , AW885592 AW885594 AW885579 AW885651 412799 132817 1 AI267606 AA121045 AA126521 412811 132943.1 H06382 AW957730 AA352014 R13591 AA121201 D60420 BE263253 BE047862 Z41952 AI424991 AI693507 AI863108 AA599060 AI091148 AA598689 R39887 AA813482 AW016452 H06383 R41807 AI364268 AA620528 AI241940 AW089149 AW090733 AW088875 Z38240 AA121202 R17734
412820 1330039 1 BE001236 BE001177 BE001180 BE001234 415131 1523680 1 D61119 D81508 D81734 418512 176394.1 AW498974 T09332 R58460 AA350990 T33786 T30936 AA350905 T08592 T09274 AA224297 D54678 T08951 R15346 AW953188 AA350074
AW890649
420111 190755.1 AA255652 AA280911 AW967920 AA262684 420352 1929791 BE258835 AW968316 AA258918 AW843305 R14744 AI580388 BE071923 R36280 421030 19864.1 AW161357 AI879062 AI928938 AW161097 AW161167 BE314465 AA351715 F07096 AA179034 F08510 F00653AI936671 AA476718AW772454
AI807703 R44253 AA976667 AI985186 AI650254 H38942 R84829 AA018724 AA001000 H85934 AA019126 H85609 AA017000 AA339355 AW950556
D51397 AA213981 BE548002 AI056359 AA001560 AW952113 AA317769 AI857477 AI857475 AW249771 AW162661 H38943 AA018628 R85885
AI984613 AI934765 AI796172 AW157488 AI929191 R85523 051221 D53851 H85610 AI749674 F21582 AA323145 AA019127 AA687444 T06745
AI699293 H29532 AA214029 AA223656 NM.016834 X14474 R19697 H09695 R17455 R13812 R19056 AI681231 AI59020O R37671 AA861828
AI990023 AI935669 AW005821 AA324581 H17335 R37659 R42802 R46242 R60936 R59731 H28993 AA479907 R44570 AI890696 AA308884
AA507078 R41274 AI365507 T16348 AI560453 F03259 F04722 T16312 AA016081 AW073061 BE314824 W28930 R44098 R51045
422890 2227071 Z43784 R13382 AW572911 AA449369 H17037 R19603 AI632565 AW004030 BE502530 Z25032 AA805324 AA449241 AI651825 AI264863 AW196918
AA948267 AI953735AI263703 AA319159 AW964436AI903440 AW594171 AI867447 AW204071 AW956110 C15616 D81142 H17038 AW162343
T87230 AI366013 H10064 AI190479 AI093318 AI867923 BE219303 BE048820 AI198397 AA654667 Z39851 F02655 Z28734 F04161 T16575 F10145
AA318815 R40898
423476 22861.1 AL035633 F11794 F11783 H18042 T66089 H29379 R19493 AW134660 AI299437 AL133995 AA057405 N78357 AA917450 AI002692 T09262 T65008
H29290 AI200874 AA894415 AI732887 AI791768 AI733447 AA988785 N62128 T09261 AW956936
424009 234177.1 F11690 AW965370 AA333586 D30830 424572 24097.1 M19650 R18810 R18721 AW896146 AW889520 AA192362 AA176814 F12085 BE255264 BE251393 T65248 AA380585 AA380465 BE408684
AA459037 AW498869 AA776107 BE274289045269 M61958 AA378818 AW663180 AW672958 H08611 M78164 BE393721 AA348660 R36303
AW498662 AA019090 AA001087 AA054302 AA019775 AA018808 AA019132 AI858240 R73218 H30477 H17776 AA659570 BE276750 AL118657
AA375861 AA352427 AW581695 AI141188 N63474 AA654162 H17659 AL120696 T28867 AW498868 AI355918 AA902349 AA569098 AI088231
AI042604 AA555133 AI183611 AI608822 AI275941 AW316805 AA349486 AI355233 R85117 AW613626 R49234 AA458846 N20669 H18693 AA977567
T15423 AW002084 AI824721 N36242 AI417281 AI018212 AA912337 F09722 AA749449 AW879172 AA885427 AA916639 AI872560 F00482 H45184
AI217251 AA775807 BE390071 AA303517 AA001050 BE515169 N44066 AL133684 AI807085 AA808009 AA915914 F00007 AA019749 AL121560
AW675544 AW090233 AW072071 AI810932 AI089733 AW026222 AA770155 AI089647 AI085733 AW516061 AL037636 AL037635 AI863947 H50420
R11203 AA019133 N94772 N71842 N29047 AA778138 AA554336 AA179865 N59453 T65212 AA054270 AW806630 AA533375 D13146 AA349487
AU077160 BE255671 BE276795 BE250823 AL120301 BE311390 BE252483
424945 245223.1 AI221919 Z19967 AA348780 AW964077 AW166028 BE540193 N94800 AA452368 N99604 AI341345 AW298800 AA724961 AA931158 AI741227
AI806660 AI982626 D81263 D53937052496 AA974487 AW043854 N50483 Z39997 AI492961 AI361526 F04002 AA452141 T23551 AI472655
AI193667 AI341984 N92658 T32870 R52664 N50428 AW089291 AI934175 AI423737 D60665
425331 2501991 AW962128 AA355353 AA427363
426413 2666501 AA377823 AW954494 AI022688
426503 2682831 AA380153 AA380233 AW963529
426919 2735071 AL041228 D82004 D61361 AI203314 AI990307 AW900295 AI018308 AW087473 AW183530 AA393346 H50055 AA935601
428342 290035.2 AI739168 AA426249 AI199636 AW505198 AW977291 AA824583 AA883419 AA724079 AI015524 AI377728 AW293682 AI928140 AA731438 AI092404
AI085630 AA731340
429007 298301 1 D80642 AA443145 AL119015 AW904500
429421 30431 1 AL031658 AI693758 AL040619 AW977914 AA811957 AI352198 AW104364 AA648367 AA897604 AW341668 AI201382 AL040620
430183 314122 BE010038 AA676833 AI311783 T86895 W68032 BE064393 BE064394 BE157228 BE183282 AI936370 AA552514 T67280 AA039909
430676 32168.1 AF084866 AF084870 AF084864 AF084867 AF084869 AF084865 AF084868 AW818206 AW812038 BE144813 BE144812 AW812041 AW812040
AW812067 BE061583 BE061604 T05808 AI352469 AA580921 BE141783 BE141782 BE061601 AW814393 AW885029
430968 326269.1 AW972830 AA527647 AA489820 AA570362
432646 3519091 AW753310 AW974000 AA557840 AA558570 AW751539
432925 3563721 AA878324 AI863159 AI619686 AA570406 AI014377
433009 357371 1 AA761668 AA573621 R92814 R09670
433523 3688731 H29882 AW665533 AW149901 AI572917 AA598500 AI686466 AI336390 AW864390 AW864320
437034 4317131 AA742643 AA808575 AW976668
437056 4322621 AI147061 AA743380 AA765223 AW976398 AI803927
438458 457837.1 AW975186 AA807807 D29548
439285 47065.1 AL133916 N79113 AF086101 N76721 AW950828 AA364013AW955684 AI346341 AI867454 N54784 AI655270 AI421279 AW014882AA775552
N62351 N59253 AA626243 AI341407 BE175639 AA456968 AI358918 AA457077
441102 5096041 AA973905 AI299888 AA917019 H63235 T90771
445294 6352.1 Z45978 U79248 T77277 R24952 AA361008 AW953678 T10376 AW860579 AW860657 AW364889 AW860635 AW860658 AW905164 W21226
AA448954 W69484 AA993098 AA287413 AA449682 AI961815 W57612 AW271363 R45215 AW136256 AI865103 W69577 AI961826 AA747542
AA173746 AI961816 F07706 R39461 F04829 F05938 AA172385
445858 6525.1 AL133811 M78538 T07792AW895859AW895589 AL119422 T79876 R19494 AF131756 H18570 T08285 F11532 Z42038 AW961964 AA683391
M62092 AL119616 Z21141 AA663820Z 19748 H18462 AL120152 R43841 R37594 AA775980 F09194 AI207884 Z38142 F01555 AA020737 AL120362
AW952737 T04912
446692 689623 1 Z44514 AI352097 AI803984 AW235923 AW196558 AI954637 AI336983 447197 711623.1 R36075 AI366546 R36167 448044 747196.1 AI458682 H24240 R14537 R18426 AW867082 450582 83933.1 AI339732 AA010300 AW515041 AA768334 N29860 AA425874 AA425118 AA865829 AW936878 451320 86576.1 AW118072 AI631982 T15734 AA224195 AI701458 W20198 F26326 AA890570 N90552 AW071907 AI671352 AI375892 T03517 R88265 AI124088
AA224388 AI084316 AI354686 T33652 AI140719 AI720211 T03490 AI372637 T15415 AW205836 AA630384 T03515 T33230 AA017131 AA443303
T33623 AI222556 T33511 T33785 AI419606 D55612
452454 918306.1 AW820480 AW820288 AI902522 453739 979419 1 AL120266 AW269469 AW890114 454042 99636.3 H22570 AW292267 AW137298 AW874199 AI206120 H45263 AA788851 R49056 AW241428 AI921013 AW129293 AI684910 BE466753 AA340613
AW025969 AI202561 AI243913 AW771106 F04969 AI654847 AI494436 AW771447 AW103715 N64350 AA347011 AI431587 AA779107 AA041195
AI358894 AI421678 AI018523 AA707199 AA410309 AI366468 AW020049 AI880103 AL119553 R42410 R55722 T66767 R43035 H17396 H45331
F01659 Z38381 AA708686 AI081305 R53955AA041432 W27787
454171 1049240.1 AW854832 AW854798 AW854857 AW854816 AW854834 AW854817 455388 1287904.1 AW936234 AW936074 AW936181 AW936179 AW936217 AW936077 AW936227 AW936191 455646 1348557.1 BE064420 BE0644358E064429 BE064414 BE064400 BE064517 458912 823104.1 AI911066 AI933734 AI680888 AJ003599 459079 888710.1 AI821122 AI821866
TABLE 13C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham, et al " refers to the publicadon endded "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted Nt_posιdon Indicates nucleodde positions of predicted exons
Pkey Ref Strand Nt position
400533 6981826 Minus 277132-277595
400658 8118459 Minus 73525-73644
400777 8131663 Plus 70745-71121
401272 9797373 Minus 98374-98509
401720 6468551 Plus 7783-8468
402145 8018280 Plus 113086-114800
402604 9909420 Plus 20393-20767
402605 9909420 Minus 47680-47973
402855 9662953 Minus 59763-59909
403022 3132351 Plus 92097-92864
403142 9444521 Plus 89286-90131
403341 8569175 Plus 30699-30910
403696 3135242 Minus 143467-143634
404120 7342152 Plus 135775-136000
404185 4572584 Minus 129171-129327
404283 2276311 Minus 99460-99564
404541 8318559 Plus 103456-103664
404584 9857511 Plus 138651-139153
404632 9796668 Plus 45096-45229
404819 4678240 Plus 16223-16319,16427-16513,16736-16859,16941-17075,17170-17287,17389-17529,18261-18357,18443-18578
405238 7249119 Minus 51728-51836
405239 7249119 Plus 144345-144464,144690-144836,151750-151883,152407-152484
405348 2914717 Minus 43310-43462
405819 4007557 Plus 2830-2967
406481 9864741 Minus 91439-91579 _
TABLE 14A ABOUT 1111 GENES UP-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL CENTRAL NERVOUS SYSTEM
Table 14A lists about 1111 genes up-regulated in glioblastoma compared to normal central nervous system (CNS) These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the ratio of "average" glioblastoma to "average" CNS dssues was greater than or equal to 25 The "average" glioblastoma level was set to the 85 percendle amongst vaπous brain tumors The "average* normal CNS dssue level was set to the 85* percendle amongst vaπous CNS tissues In order to remove gene-specific background levels of non-specific hybπdizadon, the 10* percendle value amongst vaπous non-malignant dssues was subtracted from both the numerator and the denominator before the rado was evaluated
Pkey Unique Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number Unigene Title Unigene gene due
R1 Ratio of GLIOBLASTOMA to CNS
Pkey ExAccn UnigenelD Unigene Title R1
422737 M26939 Hs 119571 collagen, type III, alpha 1 (Ehlers-Danl 328
423961 D13666 Hs 136348 peπosdn (OSF-2os) 280
433001 AF217513 Hs 279905 clone HQ0310 PRO0310p1 253
414555 N98569 Hs 76422 phospholipase A2 group IIA (platelets, 243
424800 AL035588 Hs 153203 MyoD family inhibitor 226
417308 H60720 Hs 81892 KIAA0101 gene product 22 2
449539 W80363 Hs 58446 ESTs 207
453392 U23752 Hs 32964 SRY (sex determining region Y)-box 11 187
414825 X06370 Hs 77432 epidermal growth factor receptor (avian 186
444190 AI878918 Hs 10526 cysteine and glycine-nch protein 2 172
412420 AL035668 Hs 73853 bone morphogenedc protein 2 167
417130 AW276858 Hs 81256 S100 calcium-binding protein A4 (calcium 167
414217 AI309298 Hs 279898 Homo sapiens cDNA FU23165 fis, clone L 143
431941 AK000106 Hs 272227 Homo sapiens cDNA FU20099 fis, clone CO 14 3
425397 JO4088 Hs 156346 topoisomerase (DNA) II alpha (170kD) 14 1
446584 U53445 Hs 15432 downregulated in ovaπan cancer 1 139
422672 X12784 Hs 119129 collagen, type IV, alpha 1 136
402604 Target Exon 136
424635 AA420687 Hs 115455 Homo sapiens cDNA FLJ14259 fis, clone PL 130
428330 L22524 Hs 2256 matπx metalloproteinase 7 (matπlysm, 129
434078 AW880709 Hs 283683 chromosome 8 open reading frame 4 125
414761 AU077228 Hs 77256 enhancer of zeste (Drosophila) homolog 2 124
442432 BE093589 Hs 38178 hypothedcal protein FU23468 122
456759 BE259150 Hs 127792 delta (Drosophιla)-lιke 3 121
409638 AW450420 Hs 21335 ESTs 11 5
441269 AW015206 Hs 178784 ESTs 10 5
435020 AW505076 Hs 301855 DiGeorge syndrome cndcal region gene 8 105
422163 AF027208 Hs 112360 prommin (mouse)-lιke 1 10 1
444969 AI203334 Hs 160628 ESTs 10 1
430132 AA204686 Hs 234149 hypothetical protein FLJ20647 99
433437 U20536 Hs 3280 caspase 6, apoptosis-related cysteine pr 94
445101 T75202 Hs 12314 Homo sapiens mRNA, cDNA OKFZp586C1019 (f 92
413929 BE501689 Hs 75617 collagen, type IV, alpha 2 91
425187 AW014486 Hs 22509 ESTs 91
449722 BE280074 Hs 23960 cyclin B1 89
449611 AI970394 Hs 197075 ESTs 89
428242 H55709 Hs 2250 leukemia inhibitory factor (cholinergic 89
419239 AA468183 Hs 184598 Homo sapiens cDNA FLJ23241 fis, clone C 89
443731 AI083928 Hs 145418 ESTs 88
402855 NM.001839* Homo sapiens calponin 3, acid 87 447342 AI199268 Hs 19322 Homo sapiens, Similar to RIKEN cDNA 2010 86
410102 AW248508 Hs 279727 ESTs, homologue of PEM-3 [Ciona savignyi 85
420602 AF060877 Hs 99236 regulator of G-protem signalling 20 84
417426 NM.O02291 Hs 82124 laminin, beta 1 84
433800 AI034361 Hs 135150 lung type-l cell membrane-associated gly 83
417061 AI675944 Hs 188691 Homo sapiens cDNA FU12033 fis, clone HE 81
409461 AA382169 Hs 54483 N-myc (and STAT) interactor 81
414622 AI752666 Hs 76669 nicotinamide N-methyltransferase 81
430691 C14187 Hs 103538 ESTs 80
447726 AL137638 Hs 19368 matπlin 2 80
417043 NM 004369 Hs 80988 collagen, type VI, alpha 3 79
447004 AW296968 Hs 157539 ESTs 79
409799 D11928 Hs 76845 phosphosenne phosphatase-like 78
426075 AW513691 Hs 270149 ESTs, Weakly similar to 2109260A B cell 78
419938 AU076772 Hs 1279 complement component 1, r subcomponent 77
419508 AW997938 Hs 90786 ATP-bindmg cassette, sub-family C (CFTR 77
411411 AA345241 Hs 55950 ESTs, Weakly similar to KIAA1330 protein 75
436291 BE568452 Hs 344037 protein regulator of cytokinesis 1 75
422048 NM 012445 Hs 288126 spondin 2, extracellular atnx protein 75
406972 M32053 gb Human H19 RNA gene, complete eds 74
442802 AL133035 Hs 8728 hypothedcal protein DKFZp434G171 74
427581 NM 014788 Hs 179703 KIAA0129 gene product 73
409142 AL136877 Hs 50758 SMC4 (structural maintenance of chromoso 73
409902 AI337658 Hs 156351 ESTs 73
418113 AI272141 Hs 83484 SRY (sex determining region Y)-box 4 72
449961 AW265634 Hs 133100 ESTs 72
418203 X54942 Hs 83758 CDC28 protein kinase 2 72
424840 D79987 Hs 153479 extra spindle poles, S cerevisiae, homo 72
428728 NM 016625 Hs 191381 hypothedcal protein 71
429183 AB014604 Hs 197955 KIAA0704 protein 71
439451 AF086270 Hs 278554 heterochromadn-like protein 1 71
422106 D84239 Hs 111732 Fc fragment of IgG binding protein 70
406850 AI624300 Hs 172928 collagen, type I, alpha 1 70
453941 U39817 Hs 36820 Bloom syndrome 69
425234 AW152225 Hs 165909 ESTs, Weakly similar to 138022 hypothed 69
421977 W94197 Hs 110165 πbosomal protein L26 homolog 68
411078 AI222020 Hs 182364 CocoaCπsp 67
427019 AA001732 Hs 173233 hypothetical protein FU10970 67
448769 N66037 Hs 38173 ESTs 67
418400 BE243026 Hs 301989 KIAA0246 protein 66
408161 AW952912 Hs 300383 hypothetical protein MGC3032 66
440210 AW674562 Hs 125296 ESTs 66
437036 AI571514 Hs 133022 ESTs 66
411968 AI207410 Hs 69280 Homo sapiens, clone IMAGE 3636299, mRNA, 66
416658 U03272 Hs 79432 fibnllin 2 (congenital contrxtural ara 66
449300 AI656959 Hs 346514 ESTs 65
440052 AI633744 Hs 195648 ESTs, Weakly similar to 138022 hypothed 65
412326 R07566 Hs 73817 small inducible cytokine A3 (homologous 65
434808 AF155108 Hs 256150 Homo sapiens, Similar to RIKEN cDNA 2810 65
452461 N78223 Hs 108106 transcnpdon factor 65
408243 Y00787 Hs 624 interieukin 8 65
424954 NM.000546 Hs 1846 tumor protein p53 (Li-Fraumem syndrome) 64
450375 AA009647 a dismtegnn and metalloproteinase doma 64
406478 Target Exon 64
427528 AU077143 Hs 179565 minichromosome maintenance deficient (S 64
439710 AF086543 gb Homo sapiens full length insert cDNA 64
458814 AI498957 Hs 170861 ESTs, Weakly similar to Z195 HUMAN ZINC 64
410276 AI554545 Hs 68301 angιopoιetιn-2 64
425289 AW139342 Hs 155530 interferon, gamma-inducible protein 16 63
427871 AW992405 Hs 59622 Homo sapiens, clone IMAGE 3507281, mRNA, 63
436895 AF037335 Hs 5338 carbonic anhydrase XII 63
447458 AI741082 Hs 158961 ESTs 63
447439 AA313565 Hs 145020 ESTs, Weakly similar to KIAA1205 protein 63
413719 BE439580 Hs 75498 small inducible cytokine subfamily A (Cy 63
449969 AW2951 2 Hs 180187 Homo sapiens cDNA FU14337 fis. clone PL 62
440704 M69241 Hs 162 insulin-like growth factor binding prote 62
400419 AF084545 Target 62
412140 AA219691 Hs 73625 RAB6 interacdng, kmesin-like (rabkmes 62
409731 AA125985 Hs 56145 thymosin, beta, identified in neuroblast 62
424085 NM 002914 Hs 139226 replicadon factor C (acdvator 1) 2 (40 62
429469 M64590 Hs 27 glycine dehydrogenase (decarboxyladng, 61
430630 AW269920 Hs 2621 cystatin A (stefin A) 60
410064 X53416 Hs 195464 filamin A, alpha (acdn-bindmg protein- 60
432281 AK001239 Hs 274263 hypothebcal protein FU 10377 60
413627 BE182082 Hs 246973 ESTs 60
413063 AL035737 Hs 75184 chidnase 3-lιke 1 (cartilage glycoprote 59
421899 AJ011895 Hs 109281 Nef-associated factor 1 59
407182 AA312551 Hs 230157 ESTs 59
410286 AI739159 Hs 61898 DKFZP586N2124 protein 59
409829 M33552 Hs 56729 lymphocyte-specific protein 1 59
446657 AI335191 Hs 260702 ESTs Weakly similar to 2109260A B cell 58
418097 R45137 Hs 21868 ESTs 58
428450 NM 014791 Hs 184339 KIAA0175 gene product 58 419741 NM_007019 Hs 93002 ubiquitin earner protein E2-C 57
421988 AW450481 Hs 161333 ESTs 57
422283 AW411307 Hs 114311 CDC45 (cell division cycle 45, S cerevis 57
416111 AA033813 Hs 79018 chromadn assembly factor 1, subunit A ( 57
434846 AW295389 Hs 119768 ESTs 57
412567 AI750979 Hs 74034 Homo sapiens clone 24651 mRNA sequence 57
452372 AI885742 Hs 228474 ESTs 56
443247 BE614387 Hs 333893 c-Myc targetJP01 56
423198 M81933 Hs 1634 cell division cycle 25A 56
445873 AA250970 Hs 251946 poly(A)-bιndιng protein, cytoplasmic 1-1 56
437034 AA742643 gb πy91c01 s1 NCLCGAP.GCB1 Homo sapiens 56
429447 AW812452 Hs 83286 [ESTs, Weakly similar to S 14747 sphingomy 56
424687 J05070 Hs 151738 matπx metalloproteinase 9 (geladnase B 56
437695 AA769202 Hs 192142 ESTs 56
426935 NM.000088 Hs 172928 collagen, type I, alpha 1 56
453361 AA035197 Hs 107375 ESTs 55
418293 AI224483 Hs 16063 hypothedcal protein FU21877 55
405348 C7001664 gι|12698061|db)|BAB21849 1| (AB 55
458079 AI796870 Hs 54277 DNA segment on chromosome X (unique) 992 54
452799 AI948829 Hs 213786 ESTs 54
448935 AL078596 Hs 22591 nuclear receptor subfamily 2, group E, m 54
422809 AK001379 Hs 121028 hypothedcal protein FU10549 54
442547 AA306997 Hs 217484 ESTs, Weakly similar to ALU1.HUMAN ALU S 54
424009 F11690 gb HSC30D041 normalized infant brain cDN 54
440332 AI218517 Hs 188051 ESTs 54
422094 AF129535 Hs 272027 F-box only protein 5 54
443884 N20617 Hs 194397 lepdn receptor 54
422493 AW474183 Hs 250173 hypothedcal protein FU13158 54
432731 R31178 Hs 287820 fibronecdn 1 54
426108 AA622037 Hs 166468 programmed cell death 5 53
407624 AW157431 Hs 248941 ESTs 53
411048 AK001742 Hs 67991 hypothedcal protein DKFZp434G0522 53
412471 M63193 Hs 73946 endothelial cell growth factor 1 (platel 53
414020 NM 002984 Hs 75703 small inducible cytokine A4 (homologous 52
414774 X02419 Hs 77274 plasminogeπ acdvator, urokinase 52
413786 AW613780 Hs 13500 ESTs 52
454860 AW835767 gb QV4-LT0016-240200-110-b08 LT0016 Homo 52
428037 N47474 Hs 89230 potassium intermediate/small conductance 52
420311 AW445044 Hs 38207 Human DNA sequence from clone RP4-530I15 51
416737 AF154335 Hs 79691 LIM domain protein 51
445837 AI261700 Hs 145544 ESTs 5 1
425882 U83115 Hs 161002 absent in melanoma 1 51
415682 AI347128 Hs 191870 ESTs 51
414053 BE391635 Hs 75725 transgelin 2 5 1
453884 AA355925 Hs 36232 KIAA0186 gene product 51
431512 BE270734 Hs 2795 lactate dehydrogenase A 51
432593 AW301003 Hs 51483 ESTs, Weakly similar to hypothetical pro 50
433323 AA805132 Hs 159142 ESTs 50
443744 AI084326 Hs 271548 ESTs, Weakly similar to I78885 senne/th 50
410434 AF051152 Hs 63668 toll-like receptor 2 50
420018 U56387 Hs 94376 proprotein convertase subdlism/kexin t 50
419485 AA489023 Hs 99807 ESTs, Weakly similar to unnamed protein 49
446131 NM_000929 Hs 290 phospholipase A2, group V 49
412777 AI335773 Hs 270123 ESTs 49
449246 AW411209 Hs 23363 hypothetical protein FU 10983 49
433244 AB040943 Hs 271285 KIAA1510 protein 49
407235 D20569 Hs 169407 SAC2 (suppressor of adin utadons 2, y 49
445118 AI208762 Hs 345572 ESTs 49
417404 NM.007350 Hs 82101 pleckstnn ho ology-like doman, family 49
420092 AA814043 Hs 88045 ESTs 49
412811 H06382 ESTs 49
436607 AW661783 Hs 211061 ESTs 49
438456 AA913381 Hs 20594 ESTs 49
443883 AA114212 Hs 9930 senne (or cysteine) proteinase inhibito 49
431553 X78075 Hs 2799 cartilage linking protein 1 49
439999 AA115811 Hs 6838 ras homolog gene family, member E 49
411252 AB018549 Hs 69328 MD-2 protein 49
444381 BE387335 Hs 283713 ESTs, Weakly similar to S64054 hypotheti 48
429433 AA452899 Hs 213586 ESTs, Weakly similar to KIAA1353 protein 48
403349 NM.001406 ephπn-B3 48
402274 C19000498* gι|4567179|gb|AAD23607 1|AC00 48
426044 AA502490 Hs 170290 ESTs 48
423600 AI633559 Hs 310359 ESTs 48
425905 AB032959 Hs 318584 novel C3HC4 type Zinc finger (nπg finge 48
431117 AF003522 Hs 250500 delta (Drosophιla)-lιke 1 48
418054 NM 002318 Hs 83354 lysyl oxidase-like 2 47
441703 AW390054 Hs 192843 leucine zipper protein FKSG14 47
439627 BE621702 Hs 29076 hypothetical protein FU21841 47
445900 AF070526 Hs 125036 Homo sapiens clone 24787 mRNA sequence 47
435937 AA830893 Hs 119769 ESTs 47
403961 Target Exon 47
407862 BE548267 Hs 337986 Homo sapiens CDNA FU10934 fis clone OV 46
408523 AW833259 Hs 314287 ESTs 46 403481 Target Exon 46
423529 T87318 Hs 120411 ESTs 46
416847 L43821 Hs 80261 enhancer of fila entation 1 (cas-like do 46
453362 H14988 Hs 107375 ESTs 46
407013 U35637 gb Human nebulin mRNA partial eds 46
423757 AL049337 Hs 132571 Homo sapiens mRNA. cDNA DKFZp564P016 (fr 46
432363 AA534489 gb πf76g11 s1 NCI_CGAP_Co3 Homo sapiens 46
408380 AF123050 Hs 44532 diubiquitm 46
429149 AW193360 Hs 197962 ESTs, Weakly similar to I38022 hypothed 46
422170 AI791949 Hs 112432 and-Mulleπan hormone 46
405558 Target Exon 46
410295 AA741357 Hs 5174 nidogen (enacdn) 46
450166 AA429504 ESTs 46
451418 BE387790 Hs 26369 hypothedcal protein FU20287 45
420075 AF142482 Hs 203846 TEA domain family member 3 45
422158 L10343 Hs 112341 protease inhibitor 3, skin-deπved (SKAL 45
457465 AW301344 Hs 122908 DNA replicadon factor 45
436827 H72187 Hs 5322 guanine nudeodde binding protein (G pr 45
452620 AA436504 Hs 119286 ESTs 45
424381 AA285249 Hs 146329 protein kinase Chk2 45
444656 AI277924 Hs 145199 ESTs 45
450639 AI703186 Hs 277174 ESTs 45
424247 X14008 Hs 234734 lysozyme (renal amyloidosis) 45
423178 AI033140 Hs 124983 Homo sapiens mRNA, cDNA DKFZp564C142 (fr 45
447072 D61594 Hs 17279 tyrosylprotem sulfotransferase 1 45
447444 AK000318 Hs 18616 hypothedcal protein FU20311 44
401454 NM 014226* Homo sapiens renal tumor and 44
420560 AW207748 Hs 59115 ESTs 44
409205 AI952884 Hs 14832 ESTs, Moderately similar to unnamed prot 44
451129 BE072881 gb RC2-BT0548-200300-012-e09 BT0548 Homo 44
412530 AA766268 Hs 266273 hypothetical protein FLJ 13346 44
447752 M73700 Hs 105938 lactotransfemn 44
429083 Y09397 Hs 227817 BCL2-related protein A1 44
418283 S79895 Hs 83942 cathepsin K (pycπodysostosis) 43
424736 AF230877 Hs 152701 microtubule-interacdπg protein that ass 43
416379 N38857 Hs 203933 ESTs 43
452994 AW962597 Hs 31305 KIAA1547 protein 43
437834 AA769294 Hs 283854 gb nz36g03 s1 NCI CGAP GCB1 Homo sapiens 43
441035 AI694309 Hs 126458 ESTs 43
425292 NM 005824 Hs 155545 37 kDa leucine-nch repeat (LRR) protein 43
418030 BE207573 Hs 83321 neuromedin B 43
450811 AI739486 Hs 245497 ESTs 43
438458 AW975186 gb EST387294 MAGE resequences, MAGN Homo 43
442201 AW516704 Hs 208726 ESTs 43
429732 U20158 Hs 2488 lymphocyte cytosolic protein 2 (SH2 doma 43
435677 AA694142 Hs 293726 ESTs Weakly similar to TSGA RAT TESTIS 43
442832 AW206560 Hs 253569 ESTs 43
449318 AW236021 Hs 78531 Homo sapiens Similar to RIKEN cDNA 5730 42
421027 AA761198 Hs 55254 ESTs 42
414300 AI304870 Hs 188680 ESTs 42
452874 AK001061 Hs 30925 hypothedcal protein FU10199 42
444161 N52543 Hs 142940 ESTs 42
416908 AA333990 Hs 80424 coagulation factor XIII A1 polypeptide 42
418483 W26076 Hs 221847 ESTs 42
443318 AI051603 Hs 133141 ESTs 42
415079 R43179 Hs 22895 hypothetical protein FU23548 42
416871 H98716 gb yx13d08 s1 Soares melanocyte 2NbHM Ho 42
423678 AW963357 Hs 7847 ESTs 42
429643 AA455889 Hs 167279 FYVE-finger-contaimng Rab5 effector pro 42
438875 AA827640 Hs 189059 ESTs 42
428600 AW863261 Hs 242413 hypothetical protein DKFZp434K1421 4 2
430968 AW972830 gb EST384925 MAGE resequences, MAGL Homo 42
406872 AI760903 gb wι09h08 x1 NCI_CGAP_CLL1 Homo sapiens 42
403790 NM_001334* Homo sapiens cathepsin O (CTS 4 1
409112 BE243971 Hs 50649 quinone oxidoreductase homolog 4 1
435703 AW630133 Hs 83313 GK003 protein 4 1
432625 AI243596 Hs 94830 ESTs, Moderately similar to T03094 A-kin 4 1
404407 Target Exon 4 1
412568 AI878826 Hs 74034 caveodπ 1, caveolae protein, 22kD 4 1
422087 X58968 Hs 111301 matπx metalloproteinase 2 (geladnase A 4 1
435143 R12375 Hs 194600 ESTs 4 1
447497 AW167254 Hs 205722 ESTs 4 1
456304 AI820973 gb nc21c02 y5 NCI_CGAP_Pr1 Homo sapiens 4 1
427676 AA394062 Hs 300772 tropomyosin 2 (beta) 4 1
436608 AA628980 down syndrome cntical region protein DS 4 1
453331 AI240665 ESTs 40
420004 AW975532 Hs 164039 ESTs, Moderately similar to 138022 hypot 40
412125 Y17114 Hs 73393 eyes absent (Drosophila) homolog 4 40
426215 AW963419 Hs 155223 stanniocalcin 2 40
407603 AW955705 Hs 62604 Homo sapiens, clone IMAGE 4299322 mRNA, 40
450581 AF081513 Hs 25195 TGF-beta 4 40
415323 BE269352 Hs 949 neutrophil cytosolic factor 2 (65kD, chr 40
409893 AW247090 Hs 57101 minichromosome maintenance deficient (S 40 432058 AW665996 Hs 130729 ESTs, Weakly similar to ALU1.HUMAN ALU S 40
444609 AW571659 Hs 278081 ESTs 40
445666 R59960 Hs 282386 ESTs 40
437814 AI088192 Hs 135474 ESTs, Weakly similar to DDX9_HUMAN ATP-D 40
414948 C15240 Hs 182155 ESTs 40
435542 AA687376 ESTs 40
422564 AI148006 Hs 222120 ESTs 40
449571 AW016812 Hs 200266 ESTs 40
433556 W56321 Hs 111460 calcium/calmodulin-dependent protein km 40
458946 AA009716 Hs 42311 ESTs 40
449655 AI021987 Hs 59970 ESTs 40
426649 AI914936 Hs 97152 ESTs 40
457292 AI921270 Hs 281462 hypothedcal protein FU14251 40
440435 AL042201 Hs 21273 transcnpdon factor NYD-sp10 40
456977 AK000252 Hs 169758 hypothedcal protein FU20245 40
420649 AI866964 Hs 124704 ESTs, Moderately similar to S65657 alpha 40
416406 D86961 Hs 79299 lipoma HMGIC fusion partner-like 2 40
446291 BE397753 Hs 14623 interferon, gamma-mducible protein 30 39
449256 AA059050 Hs 59847 ESTs 39
421637 AF035290 Hs 106300 Homo sapiens clone 23556 mRNA sequence 39
456306 AA225313 Hs 222886 ESTs, Weakly similar to TRHY.HUMAN TRICH 39
438372 AI140189 Hs 123191 ESTs 39
427375 AL035460 Hs 177536 metallocarboxypepddase CPX-1 39
415131 D61119 gb HUM158C118 Clontech human fetal brain 39
439231 AW581935 Hs 141480 Homo sapiens mRNA cDNA DKFZp434N079 (fr 39
424998 U58515 Hs 154138 chidnase 3-lιke 2 39
433376 AI249361 Hs 74122 caspase 4, apoptosis-related cysteine pr 39
455104 BE064863 gb RC1-BT0313-110300-015-.06 BT0313 Homo 39
443426 AF098158 Hs 9329 chromosome 20 open reading frame 1 39
419594 AA013051 Hs 91417 topoisomerase (DNA) II binding protein 39
417576 AA339449 Hs 82285 phosphoπbosylglycinamide formyltransfer 39
416857 AA188775 Hs 292453 ESTs 39
434784 AA649051 Hs 164007 ESTs 38
438898 AI819863 Hs 106243 ESTs 38
408102 U46351 Hs 621 lectin, galactoside-bind g, soluble, 3 38
422081 AW136820 Hs 196011 ESTs 38
411688 AW953440 gb EST365510 MAGE resequences, MAGB Homo 38
447343 AA256641 Hs 236894 ESTs, Highly similar to S02392 alpha-2 m 38
406395 Target Exon 38
433675 AW977653 Hs 75319 nbonucleodde reductase M2 polypeptide 38
403696 C4001100* gι|5852342|gb|AAD54015 1| (AF0 38
443740 R56434 Hs 21062 ESTs 38
413076 U10564 Hs 75188 weel (S pombe) homolog 38
409189 AA125984 gb zn27h06 r1 Stratagene neuroepithelium 38
444326 AI939357 Hs 270710 ESTs 38
436899 AA764852 Hs 291567 ESTs 38
445075 AI651827 Hs 344767 ESTs 38
416892 L24498 Hs 80409 growth aπest and DNA-damage-inducible, 38
429163 AA884766 gb am20a10 s1 Soares_NFL_T_GBC_S1 Homo s 38
416114 AI695549 Hs 183868 glucuronidase, beta 38
417018 M16038 Hs 80887 v-yes-1 Yamaguchi sarcoma viral related 38
446839 BE091926 Hs 16244 mitodc spindle coiled-coil related prot 38
454117 BE410100 Hs 40368 adaptor-related protein complex 1 , sigma 38
416664 H72780 Hs 20289 ESTs 38
449444 AW818436 Hs 23590 solute carrier family 16 (monocarboxylic 38
419735 AW750056 Hs 169577 Homo sapiens cDNA FU14743 fis, clone NT 38
448275 BE514434 Hs 20830 kinesm-like 2 37
405141 Y14443 zinc finger protein 200 37
411537 BE073250 gb MRO-BT0551-060300-102-e05 BT0551 Homo 37
422648 D86983 Hs 118893 Melanoma associated gene 37
449145 AI632122 Hs 198408 ESTs 37
428060 AA420616 Hs 249483 ESTs 37
404584 Target Exon 37
418596 AW976721 Hs 293327 ESTs 37
458072 AI890347 Hs 271923 Homo sapiens cDNA FU22785 fis, clone K 37
445908 R13580 Hs 13436 Homo sapiens clone 24425 mRNA sequence 37
439979 AW600291 Hs 6823 hypothedcal protein FU 10430 37
431770 BE221880 Hs 268555 S-3 exonbonuclease 2 37
427809 M26380 Hs 180878 lipoprotein lipase 37
436674 AA725002 Hs 272018 low molecular mass ubiquinone-binding pr 37
413450 Z99716 Hs 75372 N-acetylgalactosammidase, alpha- 37
434467 BE552368 Hs 231853 Homo sapiens cDNA FU 13445 fis, clone PL 37
448048 BE281291 Hs 170408 ESTs, Moderately similar to A47582 B-cel 37
422798 R92347 Hs 34574 ESTs, Weakly similar to ALU1.HUMAN ALU S 37
402082 C18000743* gι|6678363|ref|NP_033416 1| t 37
448019 AW947164 Hs 195641 ESTs, Moderately similar to 138022 hypot 37
428873 AI701609 Hs 98908 ESTs 37
437323 AA371145 Hs 194397 lepdn receptor 37
413095 AA494359 Hs 30715 potassium voltage-gated channel, Isk-rel 37
425139 AW630488 Hs 25338 protease, senne, 23 37
452279 AA286844 Hs 61260 hypothetical protein FU13164 37
439574 AI469788 Hs 165190 ESTs 37
408829 NM_0O6042 Hs 48384 heparan sulfate (glucosamine) 3-0-sulfot 37 407838 BE146411 Hs 40342 putative nuclear protein 37
437748 AF234882 Hs 5814 suppression of tumoπgemcity 7 36
437470 AL390147 Hs 134742 hypothedcal protein DKFZp547D065 36
400288 X06256 Hs 149609 integnn. alpha 5 (fibronectin receptor 36
453438 AI469935 Hs 22792 ESTs 36
415024 AI983981 Hs 189114 ESTs 36
419713 AW968058 Hs 92381 nudix (nucleoside diphosphate linked moi 36
441523 AW514263 Hs 301771 ESTs, Weakly similar to ALUF.HUMAN ι»ι 36
416427 BE244050 Hs 79307 Rac/Cdc42 guanine exchange factor (GEF) 36
448002 Y15227 Hs 20149 deleted in lymphocydc leukemia, 1 36
441362 BE614410 Hs 23044 RAD51 (S cerevisiae) homolog (E cod Re 36
456534 X91195 Hs 100623 phospholipase C, beta 3, neighbor pseudo 36
402239 Target Exon 36
450297 AW901347 Hs 38592 hypothedcal protein FU23342 36
443715 AI583187 Hs 9700 cyclin E1 36
403011 ENSP00000215330* Probable seπne/threoni 36
428403 AI393048 Hs 326159 leucine nch repeat (in FLU) interacdn 36
425202 AW962282 Hs 152049 ESTs, Weakly similar to I38022 hypothed 36
409557 BE182896 Hs 211193 ESTs 36
453948 AI970797 Hs 64859 ESTs 36
440225 BE295782 Hs 159 tumor necrosis factor receptor superfami 36
425331 AW962128 gb EST374201 MAGE resequences, MAGG Homo 36
442326 H92962 Hs 124813 hypothedcal protein MGC14817 36
437640 AA764893 Hs 272155 ESTs, Weakly similar to I38022 hypothed 36
424051 AL110203 Hs 138411 Homo sapiens mRNA, cDNA DKFZp586J1922 (f 36
406481 Target Exon 36
433835 AI806185 gb wf26a10 x1 Soares_NFL_T.GBC_S1 Homo s 36
456052 BE311901 Hs 28935 gb 601142614F1 NIH.MGC.14 Homo sapiens c 36
453857 AL080235 Hs 35861 DKFZP586E1621 protein 35
439726 AW449893 Hs 293707 ESTs, Weakly similar to I38598 zinc fing 35
416913 AW934714 gb RC1-DT0001-031299-011-a11 DT0001 Homo 35
419402 Z68155 Hs 90291 laminin, beta 2 (laminin S) 35
403108 ENSP00000241415* Hypothetical 677 kDa p 35
426509 M31166 Hs 2050 pentaxin-related gene, rapidly induced b 35
418883 BE387036 Hs 1211 acid phosphatase 5, tartrate resistant 35
432188 AI362952 Hs 2928 solute earner family 7 (cationic am o 35
448789 BE539108 Hs 22051 hypothedcal protein MGC15548 35
427299 AA830210 Hs 214263 ESTs Moderately similar to ALU1.HUMAN A 35
425212 AW962253 Hs 171618 ESTs 35
422938 NM.001809 Hs 1594 centromere protein A (17kD) 35
442264 AI278777 Hs 263455 ESTs, Weakly similar to ALU1_HUMAN ALU S 35
407253 AA411175 Hs 141939 ESTs, Moderately similar to S65657 alpha 35
457211 AW972565 Hs 32399 ESTs Weakly similar to S51797 vasodilat 35
452682 AA456193 Hs 9071 progesterone membrane binding protein 35
421247 BE391727 Hs 102910 general Uanscnpdon factor HH, polype 35
418049 AA211467 Hs 190488 Homo sapiens. Similar to nuclear localiz 35
453792 AL134539 Hs 254129 KIAA1678 35
416426 AA180256 Hs 210473 Homo sapiens cDNA FU14872 fis, clone PL 35
412014 AI620650 Hs 43761 ESTs, Weakly similar to A46010 X-linked 35
440370 AA884000 Hs 8173 hypothedcal protein FLJ 10803 35
407729 T40707 Hs 270862 ESTs 35
438527 AI969251 Hs 115325 RAB7, member RAS oncogene family-like 1 35
455646 BE064420 gb RC4-BT0311-241199 012-c08 BT0311 Homo 35
418630 AI351311 Hs 251946 poly(A)-bιndιng protein, cytoplasmic 1-1 35
432242 AW022715 Hs 162160 ESTs, Weakly similar to ALU4.HUMAN ALU S 35
424503 NM_002205 Hs 149609 integnn, alpha 5 (fibronecdn receptor, 34
449932 AI675444 Hs 263024 ESTs 34
427700 AA262294 Hs 180383 dual specificity phosphatase 6 34
403849 Target Exon 34
429747 M87507 Hs 2490 caspase 1, apoptosis-related cysteine pr 34
451446 AI826288 Hs 171637 hypothedcal protein MGC2628 34
434589 AF147363 gb Homo sapiens full length insert cDNA 34
403361 NM_0O2210* Homo sapiens integnn, alpha 34
420841 AI625251 Hs 94037 hypothedcal protein FU23053 34
438206 AA780385 Hs 187885 ESTs 34
425295 AA431366 Hs 37251 ESTs 34
411789 AF245505 Hs 72157 Adlican 34
440948 AW188311 Hs 128619 ESTs 34
439518 W76326 gb zd60d04 r1 Soares fetal.heart.NbHH19W 34
418821 AA436002 Hs 183161 ESTs 34
459660 M79082 ESTs 34
404209 Target Exon 34
443950 NM.001425 Hs 9999 epithelial membrane protein 3 34
430694 AA810624 Hs 30936 ESTs Weakly similar to H2BH HUMAN HISTO 34
425300 AW601773 Hs 270259 ESTs 34
420300 AA258245 Hs 127573 Homo sapiens FKSG41 (FKSG41)mRNA, compl 34
458438 AI141520 Hs 151464 ESTs, Weakly similar to ALUC.HUMAN "» 34
444911 U06117 Hs 250 xanthene dehydrogenase 34
421064 AI245432 Hs 101382 tumor necrosis factor, alpha-induced pro 34
441287 AW293132 Hs 131373 ESTs 34
446960 AW294936 Hs 156762 ESTs 34
405605 C2001342 gι|127814|sp|P26434|NAH4 RAT SO 34
433791 AA719352 Hs 112718 ESTs 34 405238 Target Exon 34
412986 X81120 Hs 75110 cannabinoid receptor 1 (bran) 34
414372 AA143654 gb zo65a02 r1 Stratagene pancreas (93720 34
435523 T62849 Hs 11090 membrane-spanning 4-domaιns, subfamily A 34
406739 AI566709 Hs 182426 πbosomal protein S2 34
442710 AI015631 Hs 23210 ESTs 34
452526 W38537 Hs 280740 hypothedcal protein MGC3040 34
456060 C14904 Hs 45184 Homo sapiens cDNA FU 12284 fis, clone MA 34
435005 U80743 Hs 306094 tπnucleodde repeat containing 12 34
421674 T10707 Hs 296355 hypothedcal protein FU23138 34
425242 D13635 Hs 155287 KIAA0010 gene product 34
436805 AA731533 Hs 270751 ESTs 34
418641 BE243136 Hs 86947 a dismtegnn and metalloproteinase doma 34
430809 AI791150 Hs 262009 ESTs, Moderately similar to I38022 hypot 34
428878 AA436884 Hs 48926 ESTs 33
413774 AA131782 Hs 182314 ESTs 33
400533 ENSP00000209376* PRED65 protein (Fragmen 33
422448 AW372922 Hs 116774 integnn, alpha 1 33
423905 AW579960 Hs 135150 lung type-l cell membrane-associated gly 33
430637 BE160081 Hs 256290 S100 calcium-binding protein A11 (calgiz 33
427899 AA829286 Hs 332053 serum amyloid A1 33
434206 AW136973 Hs 180479 ESTs, Weakly similar to S69890 mitogen i 33
453387 AI990741 Hs 252809 ESTs 33
436265 AA731331 Hs 190668 ESTs 33
412971 AA889628 Hs 35125 ESTs 33
441701 AW339828 Hs 127497 ESTs 33
418967 NM 001725 Hs 89535 bacteπcidal/peπneability-increasing pro 33
434577 R37316 Hs 179769 Homo sapiens cDNA FU22487 fis, clone H 33
418216 AA662240 Hs 283099 AF15q14 protein 33
436137 AI056769 Hs 133512 ESTs 33
428715 AW293716 Hs 53126 ESTs 33
449249 T52285 Hs 193115 Homo sapiens mRNA for KIAA1764 protein, 33
440074 AA863045 Hs 10669 ESTs, Weakly similar to T00050 hypothed 33
405046 C3000978 gι|9280045|db||BAB01579 1| (ABO 33
437816 AI823445 Hs 280699 ESTs 33
401272 C90 0559* gι|12314195|emb|CAB99338 1| (A 33
408896 AI610447 Hs 48778 mban protein 33
432343 NM 002960 HS 2961 SlOOcalcium-binding protein A3 33
407881 AW072003 Hs 40968 heparan sulfate (glucosamme) 3-O-sulfot 33
439978 BE139460 Hs 124673 Homo sapiens cDNA FLJ 11477 fis, clone HE 33
421094 AW978202 Hs 289064 hypothedcal protein FU22251 33
428722 U76456 Hs 190787 dssue inhibitor of metalloproteinase 4 33
446134 AW161234 Hs 13993 TBP-like 1 33
412281 AI810054 Hs 14119 ESTs 33
436282 R91913 Hs 272104 ESTs, Moderately similar to ALU1.HUMAN A 33
452203 X57522 transporter 1, ATP-bindmg cassette, sub 33
421307 BE539976 Hs 103305 Homo sapiens mRNA, cDNA DKFZp434B0425 (f 33
409463 AI458165 Hs 17296 hypothetical protein MGC2376 33
411565 AW851728 gb MR2-CT0222011199-007-d06 CT0222 Homo 33
410422 AL042014 Hs 63348 Homo sapiens, clone MGC 15203, mRNA, com 33
450506 NM_004460 fibroblast activation protein, alpha 33
451254 AI571016 Hs 172967 ESTs 33
423784 AKC 0039 Hs 132826 Homo sapiens cDNA FLJ14913 fis, clone PL 33
433325 AW206986 Hs 143905 ESTs 33
419896 Z99362 gb HSZ99362 DKFZpha yl Homo sapiens cDNA 33
420552 AK0O0492 Hs 98806 hypothedcal protein 33
451778 AI826131 Hs 62954 ESTs, Weakly similar to zinc finger prot 33
427584 BE410293 Hs 179718 v-myb avian myeloblastosis viral oncogen 32
433507 AI817336 Hs 191791 ESTs 32
418661 NM 001949 Hs 1189 E2F transcπption factor 3 32
440933 AI208217 Hs 142879 ESTs 32
426746 J03626 Hs 2057 undine monophosphate synthetase (orotat 32
404120 C5000537' gι|3298595|gb|AAC41376 1| (AF0 32
453920 AI133148 Hs 36602 1 factor (complement) 32
437014 AA808757 Hs 222531 ESTs, Weakly similar to S59501 interfero 32
424479 AF064238 Hs 149098 smoothelin 32
413278 BE563085 Hs 833 interferon-sdmulated protein, 15 kDa 32
425922 AL157466 Hs 162751 Homo sapiens mRNA, cDNA DKFZp761E2423 (f 32
407304 AA565832 Hs 271649 gb nj32b03 s1 NCI CGAP AA1 Homo sapiens 32
411671 BE049094 ESTs 32
420352 BE258835 gb 601117374F1 NIH.MGC 16 Homo sapiens c 32
454765 AW819629 gb RC5-ST0293-140200-014-H05 ST0293 Homo 32
410407 X66839 Hs 63287 carbonic anhydrase IX 32
412490 AW803564 Hs 288850 Homo sapiens cDNA FLJ22528 fis, clone H 32
434563 AW083994 Hs 9469 pleckstπn homology domain-containing f 32
417124 BE122762 Hs 25338 ESTs 32
407378 AA299264 Hs 57776 ESTs, Moderately similar to I38022 hypot 32
439764 T26535 Hs 22744 hypothedcal protein MGC13105 32
445936 BE543594 Hs 61478 hypothetical protein FU22329 32
446523 NM.003063 Hs 334629 sarcolipin 32
406060 Target Exon 32
432250 AA452088 Hs 274170 Opa-interacdng protein 2 32
437269 AA334384 Hs 149420 ESTs 32 449115 AW959952 Hs 37528 ESTs Weakly similar to AF090944 1 PRO06 32
425146 AW954627 gb EST366697 MAGE resequences. MAGC Homo 32
436210 AI825420 Hs 197824 ESTs 32
437698 R61837 Hs 7990 ESTs Moderately similar to I84505 calci 32
444371 BE540274 Hs 239 forkhead box M1 32
410006 AW732308 Hs 57783 eukaryotic translation initiation factor 32
445828 F05802 Hs 81907 ESTs 32
450810 BE207588 Hs 334360 transforming growth factor beta 1 induce 32
439533 W76021 gb zd64c04 1 Soares fetal heart NbHH19W 32
418079 R40058 Hs 6911 ESTs 32
418781 T41160 Hs 8404 ESTs 32
422765 AW409701 Hs 1578 baculoviral IAP repeat-containing 5 (sur 32
431319 AA873350 Hs 302232 ESTs 32
445413 AA151342 Hs 12677 CGI-147 protein 32
424947 R77952 ESTs, Weakly similar to altemadvely sp 32
429490 AI971131 Hs 23889 ESTs, Weakly similar to ALU7.HUMAN ALU S 32
426765 AA743603 Hs 172108 nucleopoπn 88kD 32
419726 U50330 Hs 1274 bone morphogenedc protein 1 32
425849 AJ000512 Hs 296323 serum/glucocorticoid regulated kinase 31
439566 AF086387 gb Homo sapiens full length insert cDNA 3 1
452574 AF127481 Hs 301946 lymphoid blast crisis oncogene 3 1
439753 BE262233 Hs 7423 hypothedcal protein from EUROIMAGE 2168 3 1
435256 AF193766 Hs 13872 cytokine-like protein C17 3 1
439570 T79925 Hs 269165 ESTs, Weakly similar to ALU1 HUMAN ALU S 31
443431 AI056847 Hs 20654 ESTs 3 1
428289 M26301 Hs 2253 complement component 2 3 1
415849 R20529 Hs 6806 ESTs 31
419652 AL157485 Hs 91973 hypothetical protein 3 1
429500 X78565 Hs 289114 hexabrachion (tenascin C, cytotacdn) 3 1
457579 AB030816 Hs 36761 HRAS-like suppressor 3 1
420579 AA278449 Hs 137429 ESTs 31
408116 AA251393 Hs 289052 Homo sapiens, Similar to RIKEN cDNA 5430 31
408247 AA053451 Hs 225632 leucine zipper protein 3 3 1
405183 NM.016358* Homo sapiens iroquois homeobo 31
420676 AI434780 Hs 4248 vav 2 oncogene 31
440286 U29589 Hs 7138 cholinergic receptor, muscaπnic 3 3 1
431176 AI026984 Hs 293662 ESTs 3 1
417918 AA209205 Hs 163754 hypothedcal protein FU 12606 31
437945 T78519 gb yd68c08 r1 Soares fetal liver spleen 31
404632 NM 022490 Homo sapiens hypothetical prot 3 1
428917 AA437337 Hs 16689 ESTs 3 1
429940 W25215 gb zb87a09 r1 Soares.senescent.fibroblas 31
444016 AA448154 gb zw82h09 r1 Soares testis NHT Homo sap 3 1
430701 AI760833 Hs 293971 ESTs 3 1
402229 BE262804 mitochondrial nbosomal protein S2 31
454177 AW807321 gb MR4-ST0062 240300-003-g05 ST0062 Homo 3 1
400090 Eos Control 3 1
419326 W94915 Hs 42419 ESTs 31
435644 AA700867 Hs 269659 ESTs 31
433042 AW193534 Hs 281895 Homo sapiens cDNA FU11660 fis, clone HE 31
458810 BE407125 Hs 231510 ESTs 31
414403 AW969551 Hs 76064 πbosomal protein L27a 3 1
449670 F07693 Hs 85603 Homo sapiens mRNA, cDNA DKFZp434K2172 (f 3 1
403288 C1001737*gι|7511201|pιr||T27904 hypothe 3 1
430535 AW968485 gb EST380561 MAGE resequences, MAGJ Homo 3 1
455899 BE155112 gb PM1-HT035O-151299-003-a03 HT0350 Homo 3 1
432044 AW972727 gb EST384819 MAGE resequences MAGL Homo 31
443105 X96753 Hs 9004 chondroidn sulfate proteoglycan 4 (mela 31
423789 AK002084 Hs 132851 hypothedcal protein FU11222 3 1
439538 AA837323 Hs 56407 ESTs 31
437681 AI207958 Hs 166556 Homo sapiens Similar to TEA domain fami 31
433577 AW007080 Hs 284192 ESTs 31
443021 AA368546 Hs 8904 lg superfamily protein 3 1
433894 AI907682 Hs 243293 ESTs 31
414884 R54418 Hs 183745 hypothedcal protein FU13456 3 1
408996 AI979168 Hs 344096 glycoprotein (transmembrane) nmb 3 1
449162 AI632740 Hs 10476 ESTs 31
417893 AA290605 Hs 190002 ESTs 3 1
433578 BE336886 Hs 3416 adipose differendadon-related protein 30
438380 T06430 Hs 6194 chondroidn sulfate proteoglycan BEHAB/b 30
450756 AI733488 Hs 144062 ESTs 30
422631 BE218919 Hs 118793 hypothetical protein FU10688 30
414733 BE514535 Hs 77171 minichromosome maintenance deficient (S 30
431019 NM 005249 Hs 2714 forkhead box G1B 30
434503 T96231 Hs 17762 ESTs 30
455481 AW948317 gb RC0-MT0015-280300-021 a09 MT0015 Homo 30
427413 BE547647 Hs 177781 hypothetical protein MGC5618 30
414396 BE548266 Hs 76057 galactose-4-epιmerase, UDP- 30
458760 AI498631 Hs 111334 ferπdn, light polypeptide 30
410555 U92649 Hs 64311 a dismtegnn and metalloproteinase doma 30
411543 AW851248 gb IL3-CT0220-160200-066-F01 CT0220 Homo 30
435375 AI733610 Hs 187832 ESTs 30
407047 X65965 gb H sapiens SOD-2 gene for manganese su 30 432065 AA401039 Hs 2903 protein phosphatase 4 (formeriy X), cata 30
443338 R99575 Hs 302908 ESTs 30
433062 AK001757 Hs 281348 hypothetical protein FU10895 30
412135 AW895309 gb QV4-NN0038-300300-155-e07 NN0038 Homo 30
418669 U85992 Hs 87197 Human clone IMAGE 35527 unknown protein 30
449385 AI650471 Hs 347290 ESTs 30
426384 AI472078 Hs 303662 hypothedcal protein FU13189 (FU13189) 30
436267 AW450938 Hs 180115 ESTs 30
440388 AI693520 Hs 223000 ESTs 30
427235 AM 26288 Hs 192232 ESTs 30
420116 NM 013241 Hs 95231 FH1/FH2 doman-containing protein 30
419764 BE262524 Hs 93183 vasodilator-stimulated phosphoprotein 30
406673 M34996 Hs 198253 major histocompadbility complex, class 30
445921 AW015211 Hs 146181 ESTs 30
427695 R88483 Hs 172862 ESTs 30
453324 W26592 Hs 232089 ESTs 30
404272 Target Exon 30
428538 AA446440 Hs 98643 ESTs 30
442786 H50733 Hs 256261 ESTs, Moderately similar to ALU8_HUMAN A 30
444396 T65213 Hs 4257 ESTs 30
440483 AI200836 Hs 150386 ESTs 30
429973 AI423317 Hs 164680 ESTs 30
450125 AA005418 Hs 158186 ESTs 30
417409 BE272506 Hs 82109 syndecan 1 30
429569 AA454993 Hs 138343 ESTs, Weakly similar to I78885 seπne/th 30
455778 BE088746 gb CM2-BT0693-210300-123-d09 BT0693 Homo 30
427954 J03060 Hs 247551 metaxm 1 30
422418 AK001383 Hs 116385 hypothedcal protein FU10521 30
427527 AI809057 Hs 293441 immunoglobulin heavy constant mu 30
416677 T83470 Hs 334840 ESTs, Moderately similar to I78885 senn 30
451130 AI762250 Hs 345554 ESTs 30
431431 AL096711 Hs 252953 Human DNA sequence from clone RP3-403A15 30
425248 AW957442 Hs 252766 ESTs 30
422757 AI909935 Hs 65551 Homo sapiens, Similar to DNA segment, Ch 30
431836 AF178532 Hs 271411 beta-site APP-cleavmg enzyme 2 30
416355 H49875 Hs 268906 ESTs 30
426406 AI742501 Hs 169756 complement component 1, s subcomponent 30
419829 AI924228 Hs 115185 ESTs, Moderately similar to PC4259 fem 30
412646 NM 006825 Hs 74368 transmembrane protein (63kD), endoplasmi 29
423869 BE409301 Hs 134012 C1q-related factor 29
422710 AW936566 Hs 201876 ESTs 29
445906 N28939 Hs 13434 Homo sapiens clone 24418 mRNA sequence 29
429751 M55210 Hs 214982 laminin, gamma 1 (formeriy LAMB2) 29
430413 AW842182 Hs 241392 small inducible cytokine A5 (RANTES) 29
443433 R44743 Hs 301667 ESTs 29
444145 BE153823 Hs 282385 ESTs, Weakly similar to 2004399A chromos 29
425262 087119 Hs 155418 GS3955 protein 29
442476 AF069475 gb AF069475 Homo sapiens astrocytoma lib 29
443361 AI792628 Hs 133273 ESTs 29
427144 X95097 Hs 2126 vasoacdve intestinal pepdde receptor 2 29
415709 AA649850 Hs 278558 ESTs 29
453385 AW296101 Hs 252806 ESTs 29
442609 AL020996 Hs 8518 selenoprotein N 29
443378 AW392550 Hs 9280 proteasome (prosome, macropam) subumL 29
414416 AW409985 Hs 76084 hypothedcal protem MGC2721 29
443502 AI074528 Hs 133949 ESTs 29
444143 AW747996 Hs 160999 ESTs, Moderately similar to A56194 throm 29
416308 AW291942 Hs 23628 3 beta-hydroxy-delta 5-C27-steroιd oxido 29
447674 BE270640 Hs 19192 cyclin-dependent kinase 2 29
408989 AW361666 Hs 49500 KIAA0746 protein 29
427418 AA402587 Hs 325520 LAT1-3TM protein 29
408788 AL134947 Hs 213956 Homo sapiens BAC clone RP11-10205 from Y 29
426827 AW067805 Hs 172665 methylenetetrahydrofolate dehydrogenase 29
403290 C10001011 ' gι|4758212|reqNP_004411 11 d 29
430890 X54232 Hs 2699 glypican 1 29
441217 AI922183 Hs 213246 ESTs 29
418287 AI872319 Hs 78935 methionine aminopeptidase, elF-2-assocιa 29
443836 BE221613 Hs 140553 ESTs 29
451527 AF022813 Hs 26518 transmembrane 4 superfamily member 7 29
418110 R43523 Hs 217754 hypothedcal protein FU22202 29
420886 AA805453 ESTs, Weakly similar to T29012 hypothed 29
439379 AA835002 Hs 125611 ESTs 29
426197 AA004410 Hs 100009 acyl-Coenzyme A oxidase 1, palmitoyl 29
406679 AA070786 gb zm66b07 r1 Stratagene neuroepithelium 29
454120 AB032990 Hs 40719 hypothedcal protein KIAA1164 29
457244 AA581385 Hs 162473 ESTs, Weakly similar to 138022 hypothed 29
432036 AF224266 Hs 272373 interieukin 20 29
457364 AW971037 gb EST383123 MAGE resequences. MAGK Homo 29
437860 AA333063 Hs 279898 Homo sapiens cDNA FU23165 fis, clone L 29
453544 AA831785 Hs 171914 Homo sapiens cDNA FU 14209 fis, clone NT 29
454968 AW849046 gb IL3-CT0214-15030O-085-H06 CT0214 Homo 29
437528 N59646 Hs 169745 crumbs (Drosophila) homolog 1 29
400850 Target Exon 29 428896 AW291932 Hs 98936 ESTs 29
426140 AF131798 Hs 343768 Homo sapiens clone 25119 mRNA sequence 29
408872 AI476139 Hs 13291 ESTs 29
414799 AI752416 Hs 77326 insulin-like growth factor binding prote 29
406646 M33600 Hs 308026 mapr histocompatibility complex, class 29
416569 H64891 gb yr68h03 r1 Soares fetal liver spleen 29
439130 AA306090 Hs 124707 ESTs 29
451433 AA021140 Hs 269265 ESTs, Weakly similar to A46010 X-linked 29
430314 AA369601 Hs 239138 pre-B-cell colony-enhancing factor 29
424308 AW975531 Hs 154443 minichromosome maintenance deficient (S 29
420172 AA601122 Hs 95655 secreted and transmembrane 1 29
442485 BE092285 Hs 29724 hypothedcal protein FU13187 29
416505 H66470 Hs 16004 ESTs 29
415198 AW009480 Hs 943 natural killer cell transcπpt 4 29
420674 NM 000055 Hs 1327 butyrγlcholiπesterase 29
452139 AA099969 Hs 16331 Homo sapiens cONA FU21482 fis, clone C 28
447499 AW262580 Hs 147674 protocadhenn beta 16 28
411373 BE326276 Hs 8861 ESTs 28
456816 AK001509 Hs 144391 hypothedcal protein FU 10647 28
414232 W86946 Hs 238246 hypothedcal protein FU22479 28
416188 BE157260 Hs 79070 v-myc avian myelocytomatosis viral oncog 28
447733 AF157482 Hs 19400 MAD2 (mitodc arrest deficient, yeast, h 28
438624 AA889055 Hs 123468 ESTs 28
452102 U04343 Hs 27954 CD86 andgen (CD28 andgen ligand 2, B7- 28
408716 AI567839 Hs 151714 Homo sapiens mRNA for KIAA1769 protein, 28
424028 AF055084 Hs 153692 Homo sapiens cDNA FU14354 fis, done Y7 28
421679 AI475110 Hs 203933 ESTs 28
450651 W79000 Hs 44545 ESTs, Weakly similar to B34087 hypotheti 28
452785 AL359942 Hs 296434 erythroid differentiation and denuclead 28
432842 AW674093 Hs 334822 hypothedcal protein MGC4485 28
403291 Target Exon 28
453096 AW294631 Hs 11325 ESTs 28
422545 X02761 Hs 287820 fibronectin 1 28
440296 D30829 Hs 180610 splicing factor proliπe/glutamine πch ( 28
427154 AL137262 Hs 325630 hypothetical protein MGC4289 28
422282 AF019225 Hs 114309 apolipoprotein L 28
434868 R50032 Hs 159263 collagen, type VI, alpha 2 28
414727 BE466904 Hs 190162 gb hz28f03 x1 NCI.CGAP.GCβ Homo sapiens 28
437437 AA226869 hypothedcal protein DKFZp762L0311 28
427722 AK000123 Hs 180479 hypothedcal protein FLJ20116 28
443623 AA345519 Hs 9641 complement component 1, q subcomponent, 28
444006 BE395085 Hs 10086 type I transmembrane protein Fn14 28
448432 AI783586 Hs 208575 ESTs 28
453682 T79703 gb yd71e08 r1 Soares fetal liver spleen 28
447527 AI702896 Hs 42091 ESTs 28
418557 BE140602 Hs 246645 ESTs 28
409157 AA064631 gb zf72c03 s1 Soares _pιneal_gland_N3HPG 28
457653 AI820719 Hs 154662 DnaJ (Hsp40) homolog subfamily A, membe 28
456908 AI953671 Hs 220994 hypothetical protein FLJ 14129 28
439220 AW295340 Hs 130417 ESTs, Weakly similar to Z195.HUMAN ZINC 28
418312 AW972468 Hs 170307 Ral guanine nucleotide exchange factor R 28
454581 AW809189 gb MR4-ST0118-261099-012-e10 ST0118 Homo 28
419169 AW851980 Hs 262346 ESTs, Weakly similar to S72482 hypotheti 28
400645 Target Exon 28
413951 AW051200 Hs 75640 natnuredc pepdde precursor A 28
441360 AI091713 Hs 106597 Homo sapiens, Similar to RIKEN cDNA 1110 28
404150 Target Exon 28
402936 ENSP00000217246* DJ803K15 1 (novel prote 28
454457 AW753456 gb QV2-CT0261-261099-011-d11 CT0261 Homo 28
439544 W26354 Hs 28891 hypothetical protein FLJ11360, artemis p 28
403969 ENSP00000034663 Zinc finger protein 131 28
447183 AI554733 Hs 173182 ESTs 28
446566 H95741 Hs 17914 membrane spanning 4-domaιns, subfamily A 28
426141 C05886 Hs 293972 ESTs 28
440146 AW014231 Hs 90790 Homo sapiens cDNA FU22930 fis, clone K 28
430335 D80007 Hs 239499 KIAA0185 protein 28
447071 AW236867 Hs 244376 ESTs 28
428899 AA744610 Hs 194431 palladin 28
400658 ENSP00000237081* KIAA1217 PROTEIN (FRAGM 28
403942 Target Exon 28
420565 AI806770 Hs 30258 ESTs 28
409734 BE161664 Hs 56155 hypothedcal protein 28
456645 AF227156 Hs 110103 RNA polymerase I transcnpdon factor RR 28
401841 NM.015113 Homo sapiens KIAA0399 protein 28
447247 AW369351 Hs 287955 Homo sapiens cDNA FU13090 fis, clone NT 28
450150 AI754391 Hs 23510 Kruppel-like factor 12 28
409154 U72882 Hs 50842 interferon-induced protein 35 28
410267 AW978005 Hs 12600 N-ethylmaleimide-sensidve factor attach 28
448224 R48700 Hs 20733 Homo sapiens cDNA FU22356 fis, clone H 28
410268 AA316181 Hs 61635 six transmembrane epithelial andgen of 28
447512 AW9581 8 Hs 129454 ESTs 28
417749 U09196 Hs 82520 polymerase (DNA-directed), delta 4 28
415293 R49462 Hs 106541 ESTs 28 416207 NM.014745 Hs 79077 Homo sapiens, clone MGC 2908, mRNA comp 28
423337 NM 004655 Hs 127337 axin 2 (conducdn, axil) 28
425128 BE561929 Hs 154718 tumor protein D52-lιke 2 27
444491 AI151091 Hs 270714 ESTs 27
428311 NM 005651 Hs 183671 tryptophan 2,3-dιoxygenase 27
430377 NM 001922 Hs 301865 dopachrome tautomerase (dopachrome delta 27
417944 AU077196 Hs 82985 collagen, type V, alpha 2 27
444153 AK001610 Hs 10414 hypothedcal protein FU 10748 27
438138 R98299 Hs 177502 ESTs 27
425421 L11669 Hs 157145 tetracycline transporter-like protein 27
431070 AW408164 Hs 249184 transcπption factor 19 (SC1) 27
451748 AK001612 Hs 26962 Homo sapiens cDNA FU 10750 fis, clone NT 27
452085 AW239140 Hs 25614 ESTs, Weakly similar to PC4396 mucin 3 T 27
405941 Target Exon 27
417395 BE564245 Hs 82084 integnn beta 3 binding protein (beta3-e 27
449667 AB023227 Hs 23860 KIAA1010 protein 27
428808 AA436007 Hs 188780 ESTs 27
425843 BE313280 Hs 159627 death associated protein 3 27
438025 AW501360 Hs 258910 ESTs 27
400924 Target Exon 27
412898 AI129903 Hs 74669 vesicle-associated membrane protein 5 (m 27
413834 BE296896 Hs 224179 ESTs, Weakly similar to 138022 hypothed 27
453785 AI368236 Hs 283732 ESTs, Moderately similar to ALU1.HUMAN A 27
406736 AI254733 Hs 182426 nbosomal protein S2 27
414280 BE410769 Hs 75873 zyxin 27
434203 BE262677 Hs 283558 hypothedcal protein PR01855 27
442621 AI004333 Hs 130553 ESTs, Weakly similar to ALUA.HUMAN "« 27
414591 AI888490 Hs 55902 ESTs, Weakly similar to ALU8_HUMAN ALU S 27
416547 H62914 Hs 268946 ESTs, Weakly similar to PC4259 ferπdn 27
416784 AA334592 Hs 79914 lumican 27
413851 AW897510 Hs 137387 ESTs 27
451767 AI625014 Hs 187328 ESTs 27
441668 AI611973 Hs 136313 ESTs 27
435664 AI032087 Hs 269819 ESTs 27
435046 AA662772 Hs 174330 ESTs, Weakly similar to ALU1 HUMAN ALU S 27
439467 AW292275 Hs 158365 ESTs 27
441329 AI203575 Hs 46821 hypothetical protein FU20086 27
426925 NM.001196 Hs 315689 Homo sapiens cDNA FU22373 fis, clone H 27
427241 AA399988 Hs 112087 Human DNA sequence from clone RP11-530N1 27
449919 AI674685 Hs 200141 ESTs 27
458070 AW503578 Hs 209406 ESTs Weakly similar to I38600 zinc fing 27
444794 AI419991 Hs 145225 ESTs 27
410781 AI375672 Hs 165028 ESTs 27
449520 R34993 Hs 226666 ESTs, Moderately similar to I54374 gene 27
439481 AF086294 Hs 125844 ESTs 27
401702 NM.001171" Homo sapiens ATP-bindmg cass 27
432890 NM 014442 Hs 279751 sialic acid binding Ig-like lecdn 8 27
435545 AA687415 Hs 28107 ESTs 27
416422 H60457 ESTs, Moderately similar to ZN91.HUMAN Z 27
429415 NM.002593 Hs 202097 procollagen C-endopepddase enhancer 27
420982 AW576160 Hs 100729 KIAA0692 protein 27
431421 AW969118 Hs 108144 ESTs, Weakly similar to unnamed protein 27
444168 AW379879 gb RC1-HT0256-081199-011-f01 HT0256 Homo 27
419964 AA811657 Hs 220913 ESTs 27
424480 AA341442 Hs 205299 ESTs 27
436314 AI983409 Hs 189226 ESTs 27
405516 ENSP00000200457* Thyroid receptor intera 27
449340 AW235786 Hs 195359 hypothedcal protein MGC10954 27
457876 AI821940 ESTs, Moderately similar to ALU8_HUMAN A 27
423799 AW026300 Hs 132906 19A24 protein 27
422551 AW967284 gb EST379359 MAGE resequences, MAGJ Homo 27
404592 NM.022739* Homo sapiens E3 ubiquitin lig 27
424200 AA337221 gb EST41944 Endometπal tumor Homo sapie 27
428612 AA770001 Hs 188778 ESTs 27
446139 H77395 Hs 39749 ESTs 27
440478 AI733047 Hs 130005 ESTs 27
429612 AF062649 Hs 252587 pituitary tumor-transforming 1 27
422530 AW972300 Hs 118110 bone marrow stromal cell andgen 2 27
423713 AW754182 gb RC2-CT0321-131199-011-C01 CT0321 Homo 27
402032 ENSP00000251056* Plasma membrane calcium 27
424186 AI536021 Hs 288706 Homo sapiens cDNA FU10281 fis, clone HE 27
402799 Target Exon 27
423352 AA324808 Hs 193576 ESTs 27
412021 AW885592 gb RC4-OT0071-090300-011-g11 OT0071 Homo 27
458617 Z25900 Hs 18724 Homo sapiens mRNA, cDNA DKFZp564F093 (fr 27
404170 NM 000636* Homo sapiens superoxide dismu 27
410886 AW809324 gb MR4-ST0121-141099-010-G06_1 ST0121 Ho 27
414988 C17535 gb C17535 Human placenta cDNA (TFu|iwara 27
450325 AI935962 Hs 26289 ESTs 27
458918 H56499 Hs 252692 ESTs, Weakly similar to I38022 hypothed 27
405760 Target Exon 27
406789 AI041403 πbosomal protein L29 27
424686 AA345504 gb EST51529 Gall bladder II Homo sapiens 27 400335 Y13187 Hs 248068 Homo sapiens dmd gene, intron 11 27
435065 BE064391 gb RC4-BT0310-110300-015-b08 BT0310 Homo 27
419373 NM.003244 Hs 90077 TG-interact g factor (TALE family homeo 27
406785 AA588061 gb nk10d03 s1 NCI_CGAP_Co2 Homo sapiens 27
433006 BE242758 Hs 190223 ESTs. Moderately similar to T29285 hypot 27
428690 AI948490 Hs 98765 ESTs 27
432692 AW974944 Hs 200577 ESTs 27
439699 AF086534 Hs 187561 ESTs, Moderately similar to ALU1.HUMAN A 27
452811 AA937079 Hs 118983 hypothedcal protein FLJ12150 26
457035 AA398074 Hs 119143 ESTs, Moderately similar to KIAA1513 pro 26
427725 U66839 Hs 180533 mitogen-acdvated protein kinase kinase 26
433681 AI004377 Hs 200360 Homo sapiens cDNA FU13027 fis, done NT 26
423748 AI149048 Hs 30211 hypothetical protein FU22313 26
422764 AI767727 Hs 47522 ESTs 26
403431 Target Exon 26
439332 AW842747 Hs 300870 Homo sapiens mRNA, cDNA DKFZp547M072 (fr 26
412749 AA378417 Hs 74564 signal sequence receptor, beta (transloc 26
409703 NM.006187 Hs 56009 2'-5'-olιgoadenylate synthetase 3 (100 k 26
405717 CX000838gι|10092633|ref|NP_055314 1| pu 26
426503 AA380153 gb EST93093 Skin tumor 1 Homo sapiens cD 26
414039 M83221 Hs 858 v-rel avian redculoendotheliosis viral 26
452683 AI089575 Hs 9071 progesterone membrane binding protein 26
447587 AW292139 Hs 115789 ESTs 26
408605 AF025374 Hs 46465 T-cell, immune regulator 1 26
407103 AA424881 Hs 256301 hypothedcal protein MGC13170 26
427395 AW298741 Hs 97861 ESTs, Moderately similar to I38022 hypot 26
435113 AA665469 Hs 117136 ESTs 26
419015 T79262 Hs 14463 ESTs 26
427648 AI376722 Hs 180062 proteasome (prosome, macropain) subumL 26
453707 AW003879 Hs 126522 Homo sapiens, clone MGC 16722 mRNA, com 26
411927 BE274009 Hs 772 glycogen synthase 1 (muscle) 26
404053 Target Exon 26
415069 AA159831 Hs 29286 ESTs, Weakly similar to I49636 DNA-b di 26
449625 NM 014253 odz (odd Oz/ten m, Drosophila) homolog 1 26
438033 T26483 Hs 6059 EGF-contaming fibulin like extracellula 26
451593 AF151879 Hs 26706 CGI-121 protein 26
435828 AA700705 Hs 13852 ESTs 26
443753 AW367578 Hs 134749 ESTs 26
416097 BE387371 Hs 118964 hypothedcal protein FU20085 26
413986 Z43567 gb HSC1FC021 normalized infant brain cDN 26
439755 AW748482 Hs 77873 B7 homolog 3 26
408371 AF161545 Hs 44439 hypothedcal protein 26
445658 AI469062 Hs 172660 ESTs 26
438166 N30158 Hs 122645 ESTs 26
449426 T92251 Hs 198882 ESTs 26
422605 H16646 Hs 118666 hypothetical protein PP591 26
415788 AW628686 Hs 78851 KIAA0217 protein 26
448966 AW372914 Hs 86149 phosphoinositol 3-phosphate-bιndιng prot 26
400295 W72838 AI905687 IL-BT095-190199-019 BT095 Homo 26
441128 AA570256 ESTs Weakly similar to T23273 hypothed 26
420372 AW960049 Hs 293660 Homo sapiens, clone IMAGE 3535476, mRNA, 26
428977 AK001404 Hs 194698 cycdn B2 26
424278 AK000723 Hs 144517 hypothedcal protein FU20716 26
445211 BE045601 Hs 118248 ESTs, Weakly similar to YC18.HUMAN HYPOT 26
412715 NM 000947 Hs 74519 pnmase, polypeptide 2A (58kD) 26
417838 R24713 Hs 22514 ESTs 26
420670 AW973577 ESTs 26
403267 Target Exon 26
454354 AW389896 gb RC4-ST0173-191099-032-e12 ST0173 Homo 26
452903 AI953425 Hs 345291 ESTs, Weakly similar to I38022 hypothed 26
427830 AA416598 Hs 98233 ESTs 26
435953 AI767087 Hs 114142 ESTs 26
430744 AA485229 Hs 105649 ESTs 26
413335 AI613318 Hs 8442 ESTs 26
416370 N90470 Hs 203697 ESTs, Weakly similar to I38022 hypothed 26
431865 AA521106 Hs 136375 ESTs, Weakly similar to S65824 reverse t 26
434274 AA628539 Hs 116252 ESTs, Moderately similar to ALU1.HUMAN A 26
447854 AW138454 Hs 11594 ESTs 26
412799 AI267606 gb aq91h03 x1 Stanley Frontal SB pool 1 26
455409 AW936832 gb PM2-DT0023-050400-003-h03 DT0023 Homo 26
408212 AA297567 Hs 43728 hypothetical protein 26
453055 AW291436 Hs 31917 Homo sapiens clone MGC 9658, mRNA, comp 26
443539 AI076182 Hs 134074 ESTs, Moderately similar to ALU6.HUMAN A 26
434898 AW500458 Hs 29956 KIAA0460 protein 26
438118 AW753311 Hs 346690 ESTs 26
431786 AW452784 Hs 220718 ESTs 26
421689 N87820 Hs 106826 KIAA1696 protein 26
429597 NM 003816 Hs 2442 a dismtegnn and metalloproteinase doma 26
424684 AW752714 Hs 5174 πbosomal protein S17 26
439823 AW665287 Hs 124514 ESTs 26
411962 AA099050 gb zk85d12 r1 Soares_pregnant utems NbH 26
445774 AI254165 Hs 339968 ESTs 26
400492 C10001573* gι|7302749|gb|AAF57827 1| (AE 26 450625 AW970107 gb EST382188 MAGE resequences MAGK Homo 26
426931 NM 003416 Hs 2076 zinc finger protein 7 (KOX 4, clone HF 1 26
440131 AI023425 Hs 222225 ESTs 26
438525 AW368528 Hs 100855 ESTs 26
412247 AF022375 Hs 73793 vascular endothelial growth factor 26
406662 X62006 Hs 172550 polypyπmidine tract binding protein (he 26
443725 AW245680 Hs 9701 growth arrest and DNA-damage-induαble, 26
402260 NM 001436* Homo sapiens fibπllaπn (FBL 26
429599 AA806106 Hs 123664 ESTs 26
429562 AI732767 Hs 158101 Homo sapiens cDNA FU 14673 fis, clone NT 26
432527 AW975028 Hs 102754 ESTs 26
434420 AA688278 Hs 194864 hypothetical protein FU22578 26
452732 BE300078 Hs 80449 Homo sapiens, clone IMAGE 3535294, mRNA, 26
424408 AI754813 Hs 146428 collagen, type V, alpha 1 26
413151 H47969 Hs 141971 ESTs, Weakly similar to ALU1 HUMAN ALU S 26
416244 N39535 Hs 32748 ESTs 26
403104 C8000064'gι|10432393|embjCAC10283 1| (A 26
400780 NM.007325* Homo sapiens glutamate recept 26
433009 AA761668 gb nz24c08 s1 NCI_CGAP_GCB1 Homo sapiens 26
424090 X99699 Hs 139262 XI AP associated factor- 1 26
403212 NM.019595 Homo sapiens intersecdn 2 (IT 26
407855 R54126 Hs 40500 similar to S cerevisiae RER1 26
406849 AA454809 Hs 172928 collagen, type I, alpha 1 26
443462 AI064690 Hs 171176 ESTs 26
439963 AW247529 Hs 6793 platelet-acdvadng factor acetylhydrola 26
450089 AI681883 Hs 209546 ESTs, Weakly similar to 2109260A B cell 26
419571 AW674962 Hs 91146 protein kinase D2 26
448140 AF146761 Hs 20450 BCM-like membrane protein precursor 26
444881 AI623288 Hs 192805 ESTs 26
420658 AW965215 Hs 130707 ESTs 26
437634 AW293046 Hs 255158 ESTs 26
426894 AI204209 Hs 143911 ESTs 26
428467 AK0O2121 Hs 184465 hypothedcal protein FU11259 26
434171 BE247688 Hs 347349 KIAA0948 protein 26
410174 AA306007 Hs 59461 DKFZP434C245 protein 26
427245 AA421022 Hs 97739 ESTs 25
437085 AA743935 Hs 202329 ESTs 25
400362 AF068294 Hs 272414 Homo sapiens HDCMB45P mRNA partial eds 25
452221 C21322 Hs 288057 hypothedcal protein FU22242 25
439079 AF085937 Hs 38348 ESTs 25
437287 AA748180 Hs 159346 hypothetical protein FU21369 25
411852 AA528140 Hs 107515 ESTs, Weakly similar to T00329 hypothed 25
427624 AA406245 Hs 24895 ESTs 25
435177 AI018174 Hs 42936 ESTs 25
449433 AI672096 Hs 9012 ESTs, Weakly similar to S26650 DNA-bmdi 25
447853 AI434204 Hs 164285 ESTs, Weakly similar to AFG1 YEAST AFG1 25
416704 H77795 Hs 39785 ESTs 25
401696 Target Exon 25
445677 H96577 Hs 6838 ras homolog gene family, member E 25
413840 AI301558 Hs 146381 RNA binding modf protem, X chromosome 25
437916 BE566249 Hs 20999 hypothetical protein FLJ23142 25
420289 N55394 Hs 96398 8oxoguanme DNA glycosylase 25
421848 X15880 Hs 108885 collagen type VI, alpha 1 25
421234 AA907153 Hs 190060 ESTs 25
414598 AI094221 Hs 135150 lung type-l cell membrane-associated gly 25
420162 BE378432 Hs 95577 cyclin-dependent kinase 4 25
458199 AW136417 hypothetical protein FU 14464 25
433523 H29882 ESTs 25
429125 AA446854 Hs 271004 ESTs, Weakly similar to 138022 hypothed 25
418399 AF131781 Hs 84753 hypothedcal protein FLJ 12442 25
404748 ENSP00000238177" Similar to kynurenme 3 25
413507 BE145360 Hs 190064 ESTs, Weakly similar to 138022 hypothed 25
418886 AA993982 Hs 130858 ESTs 25
429359 W00482 Hs 2399 atnx metalloproteinase 14 (membrane-in 25
452367 U71207 Hs 29279 eyes absent (Drosophila) homolog 2 25
436258 AW867491 Hs 107125 piasmalemma vesicle associated protein 25
459527 AW977556 Hs 291735 ESTs, Weakly similar to I78885 seπne/th 25
450543 AI394037 Hs 170296 Homo sapiens cDNA FU22090 fis, clone H 25
434818 AA650097 Hs 5996 ESTs 25
444534 AW271626 Hs 42294 ESTs 25
452113 AI859393 gb wm11 a02 x1 NCI_CGAP_Ut4 Homo sapiens 25
429115 AA446728 Hs 289020 Homo sapiens cDNA FLJ14098 fis, clone MA 25
434012 AA621425 Hs 186256 ESTs 25
447143 AW292408 Hs 152290 ESTs, Highly similar to JC2463 vasoacdv 25
449505 AI653006 Hs 195374 ESTs 25
419817 AA743434 Hs 193778 ESTs 25
457986 AA781745 Hs 126920 Homo sapiens, one IMAGE 4299555, mRNA, 25
431454 AW975980 Hs 292918 ESTs 25
425018 BE245277 Hs 154196 E4F Uanscnpdon factor 1 25
427513 AI476318 Hs 192480 ESTs 25
441318 AI078234 Hs 176130 ESTs 25
424830 AW270580 Hs 189311 ESTs, Weakly similar to putative p150 (H 25
414271 AK000275 Hs 75871 protein kinase C binding protein 1 25 446089 AI860021 Hs 345028 ESTs. Moderately similar to A47582 B-cel 25
415983 AI436798 Hs 117078 Homo sapiens cDNA FU23028 fis, done L 25
408292 AW178363 gb RC3-HT0105-010999-002-H06 HT0105 Homo 25
446862 AV660697 Hs 282700 ESTs 25
448970 AW138582 gb UI-H-BH-acw-a-06-O-UI s1 NCI_CGAP.Su 25
459200 Y09306 Hs 30148 homeodomam-interacdng protein kinase 3 25
422627 BE336857 Hs 118787 transforming growth factor, beta-induced 25
433388 AI432672 Hs 288539 hypothedcal protein FU22191 25
436222 AI208737 Hs 122810 Homo sapiens cDNA FU 11489 fis, done HE 25
441255 R06350 Hs 171635 ESTs 25
441627 AA947552 Hs 58086 branched chain aminotransferase 1, cytos 25
438714 AA814859 Hs 294112 ESTs 25
441020 W79283 Hs 35962 ESTs 25
418291 BE300369 Hs 289038 hypothedcal protein MGC4126 25
434267 AI206589 Hs 116243 ESTs 25
446821 W03766 tropomodulin 3 (ubiquitous) 25
402615 C1003844*gι|6912550|nefINP_036483 1| ol 25
416845 H95279 Hs 293788 gb yu20h02 s1 Soares fetal liver spleen 25
408253 AW807476 Hs 21051 Homo sapiens mRNA for FU00012 protein, 25
444884 AI201094 Hs 148540 ESTs 25
440826 AW383618 Hs 346256 ESTs, Moderately similar to ALU2_HUMAN A 25
431374 BE258532 Hs 251871 CTP synthase 25
458093 A1207788 Hs 343628 sialyltransferase 4B (beta-galactosidase 25
422484 AA568770 Hs 123158 Homo sapiens cDNA FU 12830 (is, clone NT 25
442804 AW30O118 Hs 131257 ESTs 25
420949 AA934063 Hs 13836 ESTs, Weakly similar to 138022 hypothed 25
451350 AI791447 gb nι13a05 y5 NCI_CGAP_Co4 Homo sapiens 25
410855 X97795 Hs 66718 RAD54 (S cerevιsιae)-lιke 25
430426 AA478807 Hs 125173 ESTs 25
418526 BE019020 Hs 85838 solute earner family 16 (monocarboxylic 25
406290 Target Exon 25
442085 AA975688 Hs 159955 ESTs 25
448148 NM 016578 Hs 20509 HBV pX associated proteιn-8 25
432888 T86823 gb yd81a08 si Soares fetal liver spleen 25
424126 AA335635 Hs 96917 ESTs 25
459727 AI906494 gb RC-BT113-060499-024 BT113 Homo sapien 25
407989 AW135208 Hs 256092 ESTs 25
404571 NM 015902* Homo sapiens progesdn induce 25
429139 F09092 Hs 66087 ESTs 25
435232 NM 001262 Hs 4854 cyclm-depeπdent kinase inhibitor 2C (p1 25
420608 BE548277 Hs 103104 ESTs 25
432668 AA558601 Hs 43296 ESTs 25
406871 AA993857 Hs 180842 πbosomal protein L13 25
443516 AA305821 Hs 9527 apoptosis related protein APR-3 25
445985 BE621800 Hs 29444 putadve small membrane protein NID67 25
424614 X54486 Hs 151242 senne (or cysteine) proteinase inhibito 25
437267 AW511443 Hs 258110 ESTs 25
458251 AL040927 Hs 210422 ESTs 25
431198 AL047634 Hs 231913 ESTs 25
413944 AW001579 Hs 9645 Homo sapiens mRNA for KIAA1741 protein, 25
420796 L34355 Hs 99931 sarcoglycan, alpha (50kD dystrophin-asso 25
428032 AW997704 Hs 11493 Homo sapiens cDNA FU13536 fis, clone PL 25
422017 NM 003877 Hs 110776 STAT induced STAT inhibito -2 25
424662 NM 002870 Hs 151536 RAB13, member RAS oncogene family 25
423779 AW071837 Hs 57971 ESTs 25
405863 Target Exon 25
458421 AI279978 Hs 22547 ESTs 25
439019 AF085902 Hs 271737 ESTs 25
412577 Z22968 Hs 74076 CD163 antigen 25
404891 Target Exon 25
419043 T19167 Hs 89566 ets vanant gene 1 25
448482 AW294078 Hs 171092 ESTs 25
426030 BE243933 Hs 108642 zinc finger protein 22 (KOX 15) 25
429109 AL008637 Hs 196352 neutrophil cytosolic factor 4 (40kD) 25
450597 AI701635 Hs 207077 ESTs 25
414386 X00442 Hs 75990 haptoglobin 25
440473 BE562314 Hs 98711 Homo sapiens, clone IMAGE 3677165, mRNA, 25
406851 AA609784 ma|or histocompadbility complex, class 25
414821 M63835 Hs 77424 Fc fragment of IgG, high affinity la, re 25
417663 R07483 Hs 180461 ESTs 25
429341 X73874 Hs 2393 phosphorylase kinase, alpha 1 (muscle) 25
450663 H43540 Hs 25292 nbonuclease HI, large subunit 25
407198 H91679 gb yv04a07 s1 Soares fetal liver spleen 25
411742 AW247593 Hs 71819 eukaryotic translation initiation factor 25
409449 H11341 Hs 13366 Homo sapiens cDNA FU23567 fis, clone L 25
TABLE 14B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
408292 1050507.1 AW178363 AW846011 AW845964 AW845988 AW845977 AW846002 409157 110363 AA064631 AA722000 AA064793
409189 110687.1 AA125984 AA127189 AA065075 AA070377 AA100017 AA079891 AA113255 AA075168 AA082764 AA083380 N84829 AA084752 AA076512 AA085119
AA085208 AA085045
410886 1225822.1 AW809324 BE144977 BE144956
411537 12488991 BE073250 BE073378 BE073379 AW850533 AW850529
411543 12491271 AW851248 AW851425 AW850805 AW851021 AW850905
411565 12497561 AW851728 AW851607AW851621 AW851702 AW851647 AW851727 AW851658AW851617 AW851628
411671 1253691 BE049094 AA700765 H86770 AA094646 R02483 C03868 N56170
411688 12540761 AW953440 T08189 AW857085
411962 1267441 AA099050 AA099526 T47733
412021 12721561 AW885592 AW885594 AW885579 AW885651
412135 1279148.1 AW895309 AW895290 AW895307 AW895397 AW895378 AW895402 AW895403 AW895311 AW895298 AW895390 AW895488 AW895468 AW895481
AW895288
412799 1328171 AI267606 AA121045 AA126521
412811 132943.1 H06382 AW957730 AA352014 R13591 AA121201 D60420 BE263253 BE047862 Z41952 AI424991 AI693507 AI863108 AA599060 AI091148 AA598689
R39887 AA813482 AW016452 H06383 R41807 AI364268 AA620528 AI241940 AW089149 AW090733 AW088875 Z38240 AA121202 R17734
413986 1407201 Z43567 H24159 AA134240
414372 1439091 AA143654 AW753140 AA213770 AW970865 AA569075 AA492132
414988 15113161 C17535 D59244 D58878 D79090
415131 15236801 D61119 D81508 D81734
416422 1593811 1 H60457 H68709 H73528 H54335 R87154
416569 16015671 H64891 R93444 R93458 R05590
416871 16267611 H98716 N90792 N24283
416913 163001 1 AW934714 BE161007 BE162500 AW749902 AW749864 BE162498 BE161005 AA190449 AW513465 BE161006 BE162499
419896 18886621 Z99362 Z99363
420352 192979.1 BE258835 AW968316 AA258918 AW843305 R14744 AI580388 BE071923 R36280
420670 1954421 AW973577 AA553621 AA279187
420886 1973441 AA805453 AA281379
422551 2177671 AW967284 AA312192 AA312203
423713 2312901 AW754182 AW754198 AA329983
424009 2341771 F11690 AW965370 AA333586 D30830
424200 2365951 AA337221 AA336756 AW966196
424686 2424861 AA345504 AA345251 AW963243
424947 245247.1 R77952 AA348809 AW959960 AW959962 AI565552 AW070702 AA973910 R85973
425146 2472441 AW954627 AW954629 AA351258 R25935
425331 2501991 AW962128 AA355353 AA427363
426503 2682831 AA380153 AA380233 AW963529
429163 3005431 AA884766 AW974271 AA592975 AA447312
429940 3108841 W25215 AA461079 AA461391
430535 3196431 AW968485 AW968670 AA480922 BE350425
430968 326269.1 AW972830 AA527647 AA489820 AA570362
432044 3407731 AW972727 AA524829 AW972733
432363 3454691 AA534489 AW970240 AW970323
432888 3557801 T86823 AI821425 AI732232 AA569589 AA570737
433009 3573711 AA761668 AA573621 R92814 R09670
433523 3688731 H29882 AW665533 AW149901 AI572917 AA598500 AI686466 AI336390 AW864390 AW864320
433835 3747581 AI806185 AA610063 AI693089 AI693075
434589 389291 AF147363 T47219 T47218
435065 3993291 BE064391 BE064395 AA663613 N99644
435542 4077441 AA687376 H74234 AW975503
436608 423613 AA628980 AI126603 BE504035
437034 4317131 AA742643 AA808575 AW976668
437437 43709.1 AA226869 AA296516 AW959753 AA186390 AL359619 AA356195 AA148427 R22748 AI033624 BE548853 H95327 AW579751 BE561649 AA397533
BE617136 AA236444 T89946 AA247450 N55777 W38725 AI743846 AI808406 AA922229 AI051464 W04713 R11251 W19656 AI042319 AA489276
AI224533 H
437945 445801 T78519 H59898 U72516
438458 4578371 AW975186 AA807807 D29548
439518 473341 W76326AF086341 W72300
439533 473491 W76021 AF088052 W72465
439566 473871 AF086387 W77884 W72711
439710 475501 AF086543 W96291 W96225
441128 51021.2 AA570256 AW014761 AA573721 AI473237 AI022165 AA554071 AA127551 N90525 AW973623 AA447991 AA243852 BE328850 AI148171 AI359627
AI005068 AI356567 AA232991 AW016855 AA906902 AA233101 AA127550 BE512923
442476 5435471 AF069475 AF069477 AF069476
444016 588991 AA448154 AV647571
444168 5938291 AW379879 AM26285 H12014
446821 694351 W03766 AI357775 AV660500 AV660731
448970 7912541 AW138582 AI638298 AI631640 AI963868 AI611082
449625 8113.1 NM.014253 AF100772 BE088769 AL022718 BE161779 AW863569 BE161640 AL039060 BE168542 AW296554 AA323193 AA235370 AW779760
N48674 AI375997 R45432 D59344 AI203107 F07491 R35360 R25094 AI913631 AI498402 T61382 AI016320 N45526 T61415 AA331486
450166 826771 AA429504 R41904 AA279467 H09648 AA007236
450375 83327.1 AA009647 AA131254 AA374293 AW954405 H04410 AW606284 AA151166 BE157467 BE157601 H04384 W46291 AW663674 H04021 H01532
AA190993 H03231 H59605 H01642 AA852876 AA113758 AA626915 AA746952 AI161014 AA099554 R69067
450506 836.1 NM.004460 U09278 U76833 AW630055 AW471133 C02434 W45237 AW793518 BE070112 AI587479 AI624429 AW190535 AI446661 AI478772
AW022667 AA528235 AA599775 AW613820 AI435793 AW594230 AI051768 AI200109 AI680296 AA436611 AW609728 W42634 AI682584 AA405569
AI685653AW0
450625 84032.1 AW970107 AA513951 AA010406
451129 859870.1 BE072881 BE072946 AI762181
451350 866945.1 AI791447 AI791327 AW886809
452113 899664.1 AI859393 BE177742
452203 903.2 X57522 AW295947 AI346197 AI304693 L21205 L21206 L21207 L21208 L21204 NM.000593 F06770 F12630 X57521 R18264 T74462 AA346259
AW602508 AA904076 F08426 H23432AA313737 AA393782 78052 AA847441 AA487637 AA135770AA353161 AI819778 AA054458AI346733
AW361447 AI4 453331 96214.1 AI240665 T53681 N77468 H51833 AA147247 R75732 C18450 R73999 AI095755 T49904 H03868 AA411580 R33395 AA410586 T48869 D63292
R31981 H12498 H02668 AA035018 R75957 AI803329 R27528 R36203 AI809932 AI808765 R78948 AA411449 AA976929 AI378760 AI378620 T48870
R7390
453682 9774541 T79703 T96307 AL079725
454177 104935Ϊ.1 AW807321 AW807262 AW177104 AW807319 AW807115 AW807344 AW807324 AW178116 BE141575 AW845849 AW807105 AW845868 BE140942
AW807178 AW807167 AW807398 AW807320 AW807306 AWB45866
454354 11298591 AW389896 AW389898 AW389906 AW609203 AW389873
454457 12072741 AW753456 AW753036 AW854868 AW854862
454581 1225710.1 AW809189 AW809219 AW813574
454765 12339051 AW819629AW854320
454860 12377321 AW835767 AW835537 BE160187
454968 12470291 AW849046 AW847956 AW849039 AW847957 AW848279 AW848698 AW849034 AW849033
455104 12537371 BE064863 BE153698 AW856751 BE153820 BE064737 BE153674 BE064730 BE065062 BE153536 AW856622 BE155079 BE064651 BE153665
BE064650 BE064691
455409 1288355.1 AW936832 AW936609 AW936657 AW936611 AW936739 AW936734 AW936779 AW936688 AW936659 AW936738 AW936827 AW936737 AW936736
AW936740 AW936833 AW936777 AW936830 AW936834 AW936829 AW936772 AW936638 AW936658 AW936636 AW936774 AW936778 AW936766
AW936776AW936831 AW9
455481 1293182.1 AW948317 AW948322 AW948329 AW948316 AW948298 AW948330 AW948325 AW948324 455646 1348557.1 BE064420 BE064435 BE064429 BE064414 BE064400 BE064517 455778 1364506.1 BE088746 BE088802 BE088755 BE088876 BE088947 BE088881 BE088952 455899 1381547.1 BE155112 BE155154 BE155087 BE155247 BE155499 BE155367 BE155452 456304 176820.1 AI820973 AI734077 AI820984 AA225796 AA225060 AA225101 457364 328154.1 AW971037 AA508019 AA492345 457876 42814.2 AI821940 N67106 AI744264 AA808846 AA643417 AA643416 Z70715 458199 504866.1 AW136417 AI141026 AI340960 AI091670 AI523802 AW572908 AI458860 AI924374 AI830572 AI400702 AI337539 AI968111 AI521308 AI492336
AI540779 AI672594 AW665077 AA971810 AA909139 AW082128 AI335251 AI807192 AW511744 AI023232 AI536899 AW207791 AI670910 AI002047
AW4
TABLE 14C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers Dunham, et al * refers to the publicadon entitled The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposidon Indicates nucleodde positions of predicted exons
Pkey Ref Strand NLposition
400492 9213749 Minus 123881-124090
400533 6981826 Minus 277132-277595
400645 8117693 Minus 58471-58716
400658 8118459 Minus 73525-73644
400780 8131663 Minus 118372-118619
400850 1927150 Minus 4506-4691
400924 7107613 Minus 30309-30498
401272 9797373 Minus 98374-98509
401454 9186923 Minus 114659-114832
401696 3417290 Minus 46209-46401
401702 1871197 Minus 68182-68325
401841 7684597 Plus 89868-90006,91920-92085
402032 7656761 Plus 62293-62475
402082 8117478 Minus 190046-190183
402229 9965022 Minus 15739-15951,16166-16779
402239 7690131 Plus 38175-38304,42133-42266
402260 3399665 Minus 113765-113910,115653-115765,116808-116940
402274 2935596 Plus 5604-6527
402604 9909420 Plus 20393-20767
402615 9926801 Plus 131390-132157
402799 3355547 Plus 35718-35899
402855 9662953 Minus 59763-59909
402936 8894303 Plus 51655-51771
403011 6693597 Minus 3468-3623
403104 7331404 Minus 41800-41973
403108 8980955 Plus 93253-93667
403212 7630897 Minus 156037-156210
403267 7887182 Plus 116078-121885
403288 8081479 Plus 133763-133899,135813-135958
403290 8083176 Plus 19288-20076
403291 7230870 Plus 95177-95435
403349 8569773 Minus 167815-168374
403361 8570313 Minus 112496-112687
403431 7139839 Plus 56509-56860
403481 9965004 Plus 93496-93633
403696 3135242 Minus 143467-143634
403790 8084957 Minus 87826-87947,89835-90002
403849 7708855 Plus 95043-96519
403942 7711825 Minus 99606-99757
403961 7596976 Minus 110393-110603
403969 8569909 Plus 31237-31375,32405-32506
404053 3548785 Plus 61797-64205
404120 7342152 Plus 135775-136000
404150 7534008 Plus 165811-165943
404170 9930793 Plus 168836-169248
404209 5006246 Minus 11247-11514
404272 9885189 Plus 83207-83355,84358-84496,90519-90720.91371-91447 404407 7329316 Minus 4815448499
404571 7249169 Minus 112450-112648
404584 9857511 Plus 138651-139153
404592 9943965 Minus 39067-39225
404632 9796668 Plus 45096-45229
404748 7263437 Plus 11446-11591
404891 7329392 Plus 84974-85125
405046 7596829 Minus 4373-4528
405141 8980911 Plus 99861-100054
405183 7209940 Plus 12335-12653
405238 7249119 Minus 51728-51836
405348 2914717 Minus 43310-43462
405516 9454624 Plus 112707-112876,113676-113854
405558 1621110 Plus 4502-4644,5983-6083
405605 5836195 Minus 117070-117270
405717 9588573 Plus 11275-11973
405760 6066938 Minus 37424-38045
405863 7657810 Plus 49410-49620
405941 6758796 Plus 2798-3444
406060 6899623 Minus 20339-20746
406290 5686274 Plus 8711-9358
406395 9256242 Minus 20805-20960
406478 9857502 Plus 68314-68523,68853-68950
406481 9864741 Minus 91439-91579
TABLE 15A ABOUT 1033 GENES UP-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT TISSUES
Table 15A lists about 1033 genes up-regulated in glioblastoma compared to normal normal adult dssues These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the rado of "average* glioblastoma to "average" normal dssues was greater than or equal to 30 The "average" glioblastoma level was set to the 85"1 percendle amongst vaπous brain tumors The "average* normal dssue level was set to the 85"1 percendle amongst vanous non-malignant adult dssues In order to remove gene- specific background levels of non-specific hybπdizadon, the 10* percendle value amongst the vanous non-malignant tissues was subtracted from both the numerator and the denominator before the rado was evaluated
Pkey Umqt iβ Eos probese it idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene tide
R1 Rado of GLIOBLASTOMA to NORMAL ADULT TISSUES
Pkey ExAccn UnigenelD Unigene Tide R1
427343 AI880044 Hs 176977 protein kinase C binding protein 2 605
431917 D16181 Hs 2868 penpheral myelin protein 2 549
418375 NM.0O3081 Hs 84389 synaptosomal associated protein, 25kD 531
428321 AI699994 Hs 2868 penpheral myelin protein 2 496
409389 AB007979 Hs 301281 Homo sapiens mRNA, chromosome 1 specific 454
435147 AL133731 Hs 4774 Homo sapiens mRNA, cDNA DKFZp761C1712 (f 439
413472 BE242870 Hs 75379 solute earner family 1 (glial high affi 427
415817 U88967 Hs 78867 protein tyrosine phosphatase, receptor-t 423
456759 BE259150 Hs 127792 delta (Drosophιla)-lιke 3 39 1
430838 N46664 Hs 169395 hypothedcal protein FU12015 379
417183 R52089 Hs 172717 ESTs 376
426325 D28114 Hs 169309 myelin-associated oligodendrocyte basic 36 5
425088 AA663372 Hs 169395 hypothedcal protein FU12015 343
429007 D80642 gb HUM092E09B Human fetal brain (TFu|iwa 339
449494 AW237014 Hs 315369 Homo sapiens cDNA FU23075 fis, clone L 339
423849 AL157425 Hs 133315 Homo sapiens mRNA, cDNA DKFZp761J1324 (f 327
429276 AF056085 Hs 198612 G protein-coupled receptor 51 32 3
413333 M74028 Hs 75297 fibroblast growth factor 1 (acidic) 290
450133 AW969769 Hs 105201 ESTs 279
412733 AA984472 Hs 74554 KIAA0080 protein 276
425842 AI587490 Hs 159623 NK-2 (Drosophila) homolog B 27 3
416829 AB013805 Hs 80220 catenin (cadheπn-associated protein), d 27 1
424140 Z48051 Hs 141308 myelin oligodendrocyte glycoprotein 252
402604 Target Exon 24 3
437204 AL110216 Hs 22826 ESTs, Weakly similar to 155214 salivary 24 3
422656 AI870435 Hs 1569 LIM homeobox protein 2 23 6
447359 NM 012093 Hs 18268 adenylate kinase 5 233
436878 BE465204 Hs 47448 ESTs 229
435708 AI362949 Hs 75169 ESTs 229
429903 AL134197 Hs 93597 cyclin-dependent kinase 5, regulatory su 22 7
439239 AI031540 Hs 235331 ESTs 224
409395 U46745 Hs 336678 dystrobrevm, alpha 22 2
425799 T08133 Hs 182906 Homo sapiens mRNA for KIAA1872 protein, 21 9
425057 AA826434 Hs 1619 achaete-scute complex (Drosophila) homol 21 3
444378 R41339 Hs 47860 neurotrophic tyrosine kinase, receptor, 21 2
444513 AL120214 Hs 7117 glutamate receptor, lonotropic, AMPA 1 21 0
419078 M93119 Hs 89584 insulmoma-associated 1 21 0
425048 H05468 Hs 164502 ESTs 209
453392 U23752 Hs 32964 SRY (sex determining region Y)-box 11 193
423853 AB011537 Hs 133466 slit (Drosophila) homolog 1 193
418110 R43523 Hs 217754 hypothedcal protein FU22202 19 2
447004 AW296968 Hs 157539 ESTs 186
439415 F05538 Hs 4273 ESTs 186
441497 R51064 Hs 23172 ESTs 18 5 425523 AB007948 Hs 158244 KIAA0479 protein 18 3
413597 AW302885 Hs 117183 ESTs 18 2
433551 AI985544 Hs 12450 protocadhenn 9 177
428392 H10233 Hs 2265 secretory granule, neuroendocnne protei 17 3
453642 AI370936 Hs 34074 dipepddylpeptidase VI 173
418338 NM 002522 Hs 84154 neuronal pentraxin I 17 1
437268 AI754847 Hs 227571 regulator of G-protem signalling 4 16 8
408604 D51408 Hs 21925 ESTs 16 6
424581 M62062 Hs 150917 catenin (cadheπn-associated protein), a 166
422980 N46569 Hs 76722 CCAAT/enhaπcer binding protein (C/EBP), 165
448302 AI480208 Hs 182906 Homo sapiens mRNA for KIAA1872 protein, 164
429466 M85835 Hs 12827 ESTs 163
441350 AB020690 Hs 7782 par aneoplastic andgen MA2 159
448672 AI955511 Hs 225106 ESTs 158
448743 AB032962 Hs 21896 KIAA1136 protein 157
415910 U20350 HS 78913 chemokine (C-X3-C) receptor 1 153
441285 NM 002374 Hs 167 microtubule-associated protein 2 152
431019 NM 005249 Hs 2714 forWiead box G1B 148
431941 AK000106 Hs 272227 Homo sapiens cDNA FU20099 (is, clone CO 143
433800 AI034361 Hs 135150 lung type-l cell membrane-associated gly 143
416370 N90470 Hs 203697 ESTs, Weakly similar to I38022 hypotheti 141
439979 AW600291 Hs 6823 hypothedcal protein FU 10430 140
444471 AB020684 Hs 11217 KIAA0877 protein 139
444783 AK001468 Hs 62180 anillm (Drosophila Scraps homolog), act 138
448595 AB014544 Hs 21572 KIAA0644 gene product 136
441440 AI807981 Hs 30495 ESTs 136
428982 NM 005097 Hs 194704 leucine-nch, glioma inactivated 1 135
424790 AL119344 Hs 13326 ESTs, Weakly similar to 2004399A chromos 133
459516 AI049662 Hs 246858 EST 132
421264 AL039123 Hs 103042 microtubule-associated protein 1B 132
428342 AI739168 Homo sapiens cDNA FU13458 fis, clone PL 13 1
408562 AI436323 Hs 31141 Homo sapiens mRNA for KIAA1568 protein, 129
412959 D87458 Hs 75090 KIAA0282 protein 129
439199 R40373 Hs 26299 ESTs 128
423419 R55336 Hs 23539 ESTs 125
445495 BE622641 Hs 38489 ESTs, Weakly similar to I38022 hypotheti 124
415849 R20529 Hs 6806 ESTs 124
452372 AI885742 Hs 228474 ESTs 124
452744 AI267652 Hs 246107 Homo sapiens mRNA, cDNA DKFZp434E082 (fr 123
426344 H41821 Hs 322469 transcπpdonal activator of the c-fos p 122
415734 NM 014747 Hs 78748 KIAA0237 gene product 12 1
426269 H15302 Hs 168950 Homo sapiens mRNA, cDNA DKFZp566A1046 (f 12 1
444119 R41231 Hs 184261 ESTs, Weakly similar to T26686 hypothed 120
409049 AI423132 Hs 146343 ESTs 11 9
434277 X77748 Hs 3786 glutamate receptor, metabotropic 3 11 9
427897 NM 017413 Hs 303084 apelin, pepdde ligand for APJ receptor 11 8
453941 U39817 Hs 36820 Bloom syndrome 11 8
424120 T80579 Hs 290270 ESTs 11 7
418738 AW388633 Hs 6682 solute earner family 7, (cationic ammo 11 7
411305 BE241596 Hs 69547 myelin basic protein 11 7
424945 AI221919 hypothedcal protein FLJ 10582 11 6
449539 W80363 Hs 58446 ESTs 11 5
409638 AW450420 Hs 21335 ESTs 11 5
441016 AW138653 Hs 25845 ESTs 11 4
429037 X81895 Hs 194765 H sapiens GENX-5624 mRNA, 3' UTR 11 3
407034 U84540 gb Human dystrobrevm isoform DTN-3 (DTN 11 2
446372 AB020644 Hs 14945 long fatty acyl-CoA synthetase 2 gene 11 2
425984 AW836277 Hs 165636 hypothedcal protein DKFZp761C07121 11 2
424432 AB037821 Hs 146858 protocadhenn 10 11 1
424893 AW295112 Hs 153648 Homo sapiens cDNA FU13303 fis, clone OV 11 1
425649 U30930 Hs 158540 UDP glycosyltransferase 8 (UDP-galactose 11 1
438380 T06430 Hs 6194 chondroidn sulfate proteoglycan BEHAB/b 11 1
423678 AW963357 Hs 847 ESTs 107
446692 Z44514 Homo sapiens mRNA for KIAA1763 protein, 107
430691 C14187 Hs 103538 ESTs 107
428728 NM.016625 Hs 191381 hypothedcal protein 106
427701 AA411101 Hs 243886 nuclear autoantigenic sperm protein (his 106
431988 AC002302 Hs 77202 protein kinase C, beta 1 105
433896 AW294729 Hs 274461 ESTs 105
431467 N71831 Hs 256398 Homo sapiens mRNA, cDNA OKFZp434E0528 (f 104
419249 X14767 Hs 89768 gamma-aminobutync acid (GABA) A recepto 10 3
445041 T64183 Hs 282982 solute earner 103
446782 AI653048 Hs 144006 ESTs 102
451952 AL120173 Hs 301663 ESTs 102
446711 AF169692 Hs 12450 protocadhenn 9 10 1
438054 AA776626 Hs 169309 ESTs 101
443785 AW449952 Hs 190125 basic-helix-loop-helix-PAS protein 101
451099 R52795 Hs 25954 interieukin 13 receptor, alpha 2 100
419863 AW952691 Hs 93485 Homo sapiens mRNA, cDNA DKFZp761 D191 (fr 100
416857 AA188775 Hs 292453 ESTs 100
435191 R15912 Hs 4817 Homo sapiens clone 24461 mRNA sequence 100
419271 N34901 Hs 238532 ESTs 99
429927 NM 001115 Hs 2522 adenylate cydase 8 (brain) 99 415293 R49462 Hs 106541 ESTs 99
440184 AB002297 Hs 7022 dedicator of cyto-kinesis 3 98
452526 W38537 Hs 280740 hypothedcal protein MGC3040 98
427304 AA761526 Hs 163853 ESTs 97
420547 AF155140 Hs 98738 gonadotropin-regulated tesdcular RNA he 96
421659 NM 014459 Hs 106511 protocadhenn 17 96
426847 S78723 Hs 298623 5-hydroxytryptamιne (serotonin) receptor 96
429656 X05608 Hs 211584 neurofilament, light polypeptide (68kD) 95
447101 N72185 Hs 44189 ESTs 95
442613 AI004002 Hs 130522 Kv chaπnel-interacdng protein 1 95
454027 R40192 Hs 21527 Human DNA sequence from clone GS1-115M3 95
445102 AW204610 Hs 22270 ESTs 95
435793 AB037734 Hs 4993 KIAA1313 protein 95
437948 AA772920 Hs 303527 ESTs 95
438209 AL120659 Hs 6111 aryl-hydrocarbon receptor nuclear transl 94
415170 R44386 Hs 164578 ESTs 93
415486 H12214 Hs 13284 ESTs. Weakly similar lo 2109260A B cell 92
435501 AW051819 Hs 129908 KIAA0591 protein 92
416072 AL110370 Hs 79000 growth associated protein 43 92
442910 AI365130 Hs 11307 ESTs, Weakly similar to T19326 hypothed 9 1
438080 AA777381 Hs 291530 ESTs, Weakly similar to ALUC HUMAN "" 9 1
425187 AW014486 Hs 22509 ESTs 91
424028 AF055084 Hs 153692 Homo sapiens cDNA FU14354 fis, clone Y7 90
430091 AB032958 Hs 233023 KIAA1132 protein 90
427540 R12014 Hs 20976 ESTs 90
447198 D61523 Hs 283435 ESTs 90
449611 AI970394 Hs 197075 ESTs 89
444124 R43097 Hs 6818 ESTs 89
451996 AW514021 Hs 245510 ESTs 88
454048 H05626 Hs 6921 ESTs 88
412266 N59006 Hs 26133 ESTs 88
433597 AA708205 Hs 100343 ESTs 87
447342 AI199268 Hs 19322 Homo sapiens, Similar to RIKEN cDNA 2010 86
450154 R15891 Hs 281587 Human (clone CTG-A4) mRNA sequence 86
410102 AW248508 Hs 279727 ESTs homologue of PEM-3 (Dona savignyi 85
423135 N67655 Hs 26411 ESTs 85
418097 R45137 Hs 21868 ESTs 84
420602 AF060877 Hs 99236 regulator of G-protem signalling 20 84
419721 NM 001650 Hs 288650 aquapoπn 4 84
449300 AI656959 Hs 346514 ESTs 84
436954 AA740151 Hs 130425 ESTs 83
425354 U62027 Hs 155935 complement component 3a receptor 1 83
424997 AL138167 Hs 96920 ESTs 83
442710 AI015631 Hs 23210 ESTs 82
449625 NM 014253 odz (odd OzΛeπ-m, Drosophila) homolog 1 82
451625 R56793 Hs 106576 alan e-glyoxylate aminotransferase 2-lι 82
413063 AL035737 Hs 75184 chitmase 3-lιke 1 (cartilage glycoprote 80
449605 AW138581 Hs 198416 ESTs 80
407886 AW969688 Hs 100826 ESTs 80
414175 AI308876 Hs 103849 hypothedcal protein DKFZp761D112 79
429946 R49390 Hs 254129 KIAA1678 79
400293 N51002 Hs 306480 Homo sapiens mRNA, cDNA DKFZp761E2112 (f 79
455601 AI368680 Hs 816 SRY (sex determining region Y)-box 2 79
409799 D11928 Hs 76845 phosphoseπne phosphatase-like 78
415279 F04237 Hs 1447 glial fibnllary acidic protein 78
429918 AW873986 Hs 119383 ESTs 78
449433 AI672096 Hs 9012 ESTs, Weakly similar to S26650 DNA-bindi 78
422411 AW749443 Hs 22511 ESTs 77
448902 Z45998 Hs 22543 Homo sapiens mRNA, cDNA DKFZp761M912 (f 77
452355 N54926 Hs 29202 G protein-coupled receptor 34 77
447414 D82343 Hs 74376 neuroblastoma (nerve dssue) protein 77
407168 R45175 Hs 117183 ESTs 76
448555 AI536697 Hs 159863 ESTs 76
428536 AI143139 Hs 2288 visinm-like 1 76
408947 AL080093 Hs 49117 Homo sapiens mRNA, cDNA DKFZp564N1662 (f 76
420362 U79734 Hs 97206 hundngdn interacting protein 1 76
435624 AF218942 Hs 24889 formin 2 76
440105 AA694010 Hs 6932 Homo sapiens clone 23809 mRNA sequence 76
412068 S72043 Hs 73133 metallothionem 3 (growth inhibitory fac 76
445568 H00918 Hs 268744 KIAA1796 protein 75
417160 N76497 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbac 75
423361 AW170055 Hs 47628 ESTs 75
456965 AW131888 Hs 172792 ESTs Weakly similar to hypothedcal pro 75
458332 AI000341 Hs 220491 ESTs 74
409902 AI337658 Hs 156351 ESTs 73
448321 NM.005883 HS 20912 adenomatous pdyposis coli like 73
420345 AW295230 Hs 25231 ESTs 73
402855 NM.001839' Homo sapiens calpoπin 3, acid 72
424481 R19453 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbac 72
425741 AF052152 Hs 159412 Homo sapiens clone 24628 mRNA sequence 72
448986 H42169 Hs 347310 hypothedcal protein FU14627 72
415651 AI207162 Hs 3815 stathmin-like-protein RB3 72
412709 AL022327 HS 74518 KIAA0027 protein 71 451621 AI879148 Hs 26770 fatty acid binding protein 7, brain 7 1
445745 AB0O7924 Hs 13245 KIAA0455 gene product 7 1
439451 AF086270 Hs 278554 heterochromadn-like protein 1 7 1
418030 BE207573 Hs 83321 neuromedin B 7 1
400292 AA250737 Hs 72472 BMP-R1B 7 1
407748 AL079409 Hs 38176 KIAA0606 protein, SCN Orcadian Oscillat 70
440435 AL042201 Hs 21273 transcπption factor NYD-sp10 70
414696 AF002020 Hs 76918 Niemann-Pick disease, type C1 70
417417 F05745 Hs 89512 ATPase, Ca transporting, plasma membrane 70
440152 AB002376 Hs 7006 KIAA0378 protein 70
422960 AW890487 Hs 63984 cadheπn 13, H-cadheπn (heart) 70
454293 H49739 Hs 134013 ESTs, Moderately similar to HK61_HUMAN H 70
447197 R36075 gb yh88b01 s1 Soares placenta Nb2HP Homo 70
426814 AF036943 Hs 172619 myelin transcnpdon factor 1 -like 69
416836 D54745 Hs 80247 cholecystokinin 69
447350 AI375572 Hs 172634 ESTs 69
440074 AA863045 Hs 10669 ESTs, Weakly similar to T00050 hypothed 69
436039 AW023323 Hs 121070 ESTs 69
444396 T65213 Hs 4257 ESTs 69
425234 AW152225 Hs 165909 ESTs, Weakly similar to I38022 hypothed 69
438330 AW450572 Hs 257316 ESTs 68
410305 AF030409 Hs 62185 solute earner family 9 (sodium/hydrogen 68
421141 AW117261 Hs 125914 ESTs 67
412788 AA120960 Hs 198416 ESTs 67
411078 AI222020 Hs 182364 CocoaCnsp 67
443455 AB001025 Hs 9349 ryanodine receptor 3 67
448769 N66037 Hs 38173 ESTs 67
441523 AW514263 Hs 301771 ESTs, Weakly similar to ALUF_HUMAN »» 67
414214 D49958 Hs 75819 glycoprotein M6A 66
439845 AL355743 Hs 56663 Homo sapiens EST from clone 41214, full 66
437036 AI571514 Hs 133022 ESTs 66
429239 AA448419 Hs 45209 ESTs 66
434164 AW207019 Hs 148135 seπne/threonine kinase 33 66
412155 R38167 Hs 12449 Homo sapiens transmembrane protein HTMP1 65
452834 AI638627 Hs 105685 KIAA1688 protein 65
441916 AA993571 Hs 129075 ESTs 65
451516 AI800515 Hs 12024 ESTs 65
434808 AF155108 Hs 256150 Homo sapiens, Similar to RIKEN cDNA 2810 65
452461 N78223 Hs 108106 transcnpdon factor 65
450375 AA009647 a dismtegnn and metalloproteinase doma 64
434811 AW971205 Hs 114280 ESTs 64
424624 AB032947 Hs 151301 Ca2-*dependent activator protein for seer 64
429250 H56585 Hs 198308 tryptophan πch basic protein 63
414245 BE148072 Hs 75850 WAS protein family, member 1 63
433447 U29195 Hs 3281 neuronal pentraxm II 63
424922 BE386547 Hs 217112 hypothedcal protein MGC10825 63
426919 AL041228 ELAV (embryonic lethal, abnormal vision, 63
411411 AA345241 Hs 55950 ESTs, Weakly similar to KIAA1330 protein 63
415669 NM 005025 Hs 78589 senne (or cysteine) proteinase inhibito 62
449048 Z45051 Hs 22920 similar to S68401 (cattle) glucose indue 62
433929 AI375499 Hs 27379 ESTs 62
423346 AI267677 Hs 127416 synaptojanin 1 62
448148 NM 016578 Hs 20509 HBV pX associated proteιn-8 62
412140 AA219691 Hs 73625 RAB6 interacdng, kmesin-like (rabkmes 62
409731 AA125985 Hs 56145 thymos , beta, identified in neuroblast 62
420608 BE548277 Hs 103104 ESTs 62
424085 NM.002914 Hs 139226 replication factor C (acdvator 1) 2 (40 62
422175 N79885 Hs 6382 ESTs, Highly similar to T00391 hypotheti 6 1
428845 AL157579 Hs 153610 KIAA0751 gene product 6 1
439274 AF086092 Hs 48372 ESTs 6 1
447499 AW262580 Hs 147674 protocadheπn beta 16 6 1
425977 R15138 Hs 165570 Homo sapiens clone 25052 mRNA sequence 6 1
453924 R49295 Hs 24886 ESTs 61
449340 AW235786 Hs 195359 hypothedcal protein MGC10954 6 1
420077 AW512260 Hs 87767 ESTs 6 1
431721 AB032996 Hs 268044 KIAA1170 protein 6 1
433701 AW445023 Hs 15155 ESTs 61
430968 AW972830 gb EST384925 MAGE resequences, MAGL Homo 6 1
429469 M64590 Hs 27 glycine dehydrogenase (decarboxyladng, 6 1
456723 Z43902 Hs 4748 adenylate cyclase activating polypeptide 60
448681 AL109781 Hs 21754 Homo sapiens mRNA full length insert cON 60
429900 AA460421 Hs 30875 ESTs 60
410909 AW898161 Hs 53112 ESTs, Moderately similar to ALU8_HUMAN A 60
432281 AK001239 Hs 274263 hypothedcal protein FU 10377 60
448243 AW369771 Hs 52620 integnn, beta 8 60
416427 BE244050 Hs 79307 Ftac/Cdc42 guanine exchange factor (GEF) 60
419704 AA429104 Hs 45057 ESTs 60
436936 AL134451 Hs 197478 ESTs 60
428409 AW117207 Hs 98523 ESTs 60
433244 AB040943 Hs 271285 KIAA1510 protein 60
439772 AL365406 Hs 10268 Homo sapiens mRNA full length insert cDN 60
408096 BE250162 Hs 83765 dihydrofolate reductase 60
419929 U90268 Hs 93810 cerebral cavernous malformadons 1 60 422544 AB018259 Hs 118140 KIAA0716 gene product 60
413627 BE182082 Hs 246973 ESTs 60
419985 H66373 Hs 5856 ESTs. Highly similar to bA393J163 [H sa 60
410366 AI267589 Hs 302689 hypothedcal protein 60
429183 AB014604 Hs 197955 KIAA0704 protein 59
430188 AL049242 Hs 234794 Homo sapiens mRNA, cDNA DKFZp564B083 (fr 59
441102 AA973905 intermediate filament protein syncoilin 59
448533 AL119710 Hs 21365 nucleosome assembly protein 1-lιke 3 59
407182 AA312551 Hs 230157 ESTs 59
437372 AA323968 Hs 283631 hypothedcal protein DKFZp547G183 59
433523 H29882 ESTs 59
444165 AL137443 Hs 10441 hypothedcal protein FU11236 59
424343 AW956360 Hs 4748 adenylate cyclase acdvadng polypepdde 59
420156 AW449258 Hs 6187 ESTs 59
422864 AA318323 Hs 12827 gb EST20390 Redna II Homo sapiens cDNA 58
446727 AB011095 Hs 16032 KIAA0523 protein 58
448543 AW897741 Hs 21380 Homo sapiens mRNA cDNA DKFZp586P1124 (f 58
430132 AA204686 Hs 234149 hypothedcal protein FU20647 58
425782 U66468 Hs 159525 cell growth regulatory with EF-hand doma 58
419629 AB020695 Hs 91662 KIAA0888 protein 58
452279 AA286844 Hs 61260 hypothedcal protein FU13164 58
407808 AA663559 Hs 279789 histone deacetylase 3 58
414737 AI160386 Hs 125087 ESTs 58
432154 AI701523 Hs 112577 ESTs 58
410099 AA081630 KIAA0036 gene product 58
411379 AI816344 Hs 12554 ESTs, Weakly similar to NPL4_HUMAN NUCLE 58
440492 R39127 Hs 21433 hypothetical protein DKFZp547J036 57
424560 AA158727 Hs 150555 protein predicted by clone 23733 57
419498 AL036591 Hs 20887 hypothedcal protein FU 10392 57
436643 AA757626 Hs 10941 ESTs, Weakly similar to IPP1_HUMAN PROTE 57
416111 AA033813 Hs 79018 chromadn assembly factor 1 , subunit A ( 57
419088 AI538323 Hs 52620 integnn, beta 8 57
436109 AA922153 Hs 132760 hypothedcal protein MGC15729 57
428588 F12101 Hs 185701 Homo sapiens mRNA full length insert cDN 57
451752 AB032997 Hs 26966 KIAA1171 protein 57
413492 D87470 Hs 75400 KIAA0280 protein 57
414683 S78296 Hs 76888 hypothetical protein MGC12702 56
418079 R40058 Hs 6911 ESTs 56
445873 AA250970 Hs 251946 poly(A)-bιndιng protein, cytoplasmic 1-1 56
437034 AA742643 gb ny91c01 s1 NCI CGAP GCB1 Homo sapiens 56
419544 AI909154 gb QV-BT200-010499-007 BT200 Homo sapien 56
452785 AL359942 Hs 296434 erythroid differendadon and denuclead 56
408081 AW451597 Hs 167409 ESTs 56
436887 AW953157 Hs 193235 hypothedcal protein DKFZp547D155 56
413589 AW452631 Hs 313803 ESTs, Highly similar to AF157833 1 noncl 56
418506 AA084248 Hs 85339 G protein-coupled receptor 39 56
433556 W56321 Hs 111460 calcium/calmodulin-dependent protein k 55
448299 AA497044 Hs 20887 hypothedcal protein FU 10392 55
425154 NM 001851 Hs 154850 collagen, type IX, alpha 1 55
447773 AI423930 Hs 36790 ESTs, Weakly similar to putative p150 (H 55
422421 AA325138 Hs 235873 hypothedcal protein FU22672 55
453128 AW026516 Hs 31791 acylphosphatase 2, muscle type 55
453220 AB033089 Hs 32452 Homo sapiens mRNA for KIAA1263 protein. 55
440866 AI703103 Hs 271360 hypothedcal protein MGC16275 54
428976 AL037824 Hs 194695 ras homolog gene family, member I 54
419723 AL120193 Hs 339810 longevity assurance (LAG1 , S cerevisiae 54
452799 AI948829 Hs 213786 ESTs 54
429038 AL023513 Hs 194766 seizure related gene 6 (mouse)-lιke 54
445255 NM 014841 Hs 12477 synaptosomal-associated protein, 91 kDa 54
424332 AA338919 Hs 101615 ESTs 54
440210 AW674562 Hs 125296 ESTs 54
414825 X06370 Hs 77432 epidermal growth factor receptor (avian 54
448935 AL078596 Hs 22591 nuclear receptor subfamily 2, group E, m 54
452786 R61362 Hs 106642 ESTs, Weakly similar to T09052 hypothed 54
408790 AW580227 Hs 47860 neurotrophic tyrosine kinase, receptor, 54
423476 AL035633 Human DNA sequence from clone RP5-1046G1 54
448507 AL133109 Hs 21333 Homo sapiens mRNA, cDNA DKFZp566N1047 (f 54
419683 AA248897 Hs 48784 ESTs 54
407728 AW071502 Hs 175931 ESTs 54
453313 BE005771 Hs 153746 hypothedcal protein FU22490 54
422094 AF129535 Hs 272027 F-box only protein 5 54
452856 AF034799 Hs 30881 protein tyrosine phosphatase, receptor t 54
434792 AA649253 Hs 132458 ESTs 54
412190 R16180 Hs 274461 ESTs 53
425588 F07396 Hs 46627 ESTs 53
444190 AI878918 Hs 10526 cysteine and glycine-πch protein 2 53
429698 AI685086 Hs 26339 ESTs, Weakly similar to S21348 probable 53
424458 M29273 Hs 1780 myelin associated glycoprotein 53
446997 AA383439 Hs 16758 Spιr-1 protein 53
427302 AA400540 Hs 135282 Homo sapiens cDNA FU11554 fis, clone HE 53
439607 BE540565 Hs 159460 ESTs 53
448499 BE613280 Hs 77550 hypothedcal protein MGC1780 53
410037 AB020725 Hs 58009 KIAA0918 protein 53 451407 AA131376 Hs 343809 fibroblast growth factor 12B 53
430287 AW182459 Hs 125759 ESTs. Weakly similar to LEU5.HUMAN LEUKE 53
428784 Y12851 Hs 193470 puπnergic receptor P2X. Iigand-gated 10 53
418512 AW498974 diacylglycerol kinase, zeta (104kD) 53
435538 AB011540 Hs 4930 low density lipoprotein receptor-related 53
420285 AA258124 Hs 293878 ESTs, Moderately similar to ZN91.HUMAN Z 52
407896 D76435 Hs 41154 Zic family member 1 (odd-paired Drosophi 52
404819 NM.0O2688* Homo sapiens peanut (Drosophi 52
426503 AA380153 gb EST93093 Skin tumor I Homo sapiens cD 52
405348 C7001664 gι|12698061|db)|BAB21849 1| (AB 52
431552 AI815863 Hs 259873 axonal transport of synapdc vesicles 52
418677 S83308 Hs 87224 SRY (sex determining region Y)-box 5 52
427250 R35941 Hs 25418 ESTs 52
428037 N47474 Hs 89230 potassium intermediate/small conductance 52
445740 T78281 Hs 13226 Homo sapiens clone 25181 mRNA sequence 52
430130 AL137311 Hs 234074 Homo sapiens mRNA, cDNA DKFZp761G02121 ( 52
423869 BE409301 Hs 134012 C1q-related factor 52
416220 N49776 Hs 170994 hypothedcal protein MGC10946 52
457005 AJ007421 Hs 172597 sal (Drosophιla)-lιke 3 51
447072 D61594 Hs 17279 tyrosylprotem sulfotransferase 1 51
414372 AA143654 gb zo65a02 r1 Stratagene pancreas (93720 51
410631 AA086469 Hs 47171 ESTs 51
414821 M63835 Hs 77424 Fc fragment of IgG, high affinity la, re 51
420133 AA426117 Hs 155543 ESTs 51
453884 AA355925 Hs 36232 KIAA0186 gene product 5 1
414922 D00723 Hs 77631 glycine cleavage system protein H (ammo 5 1
414727 BE466904 Hs 190162 gb hz28(03 x1 NCI.CGAP.GC6 Homo sapiens 51
441869 NM 003947 Hs 8004 hundngtin-associated protein interacdn 5 1
437387 AI198874 Hs 28847 AD026 protein 50
400533 ENSP00000209376* PRED65 protein (Fragmen 50
430979 AI479755 Hs 129010 ESTs 50
448944 AB014605 Hs 22599 atrophιn-1 interacdng protein 1, acdvi 50
444600 R41398 Hs 6996 ESTs 50
453785 AI368236 Hs 283732 ESTs, Moderately similar to ALU1 HUMAN A 50
428878 AA436884 Hs 48926 ESTs 50
444670 H58373 Hs 332938 hypothedcal protein MGC5370 50
440471 AA886146 Hs 307944 ESTs 50
410434 AF051152 Hs 63668 toll-like receptor 2 50
441390 AI692560 Hs 131175 ESTs 49
448765 R15337 Hs 21958 Homo sapiens mRNA, cDNA DKFZp547D086 (fr 49
422263 AA307639 Hs 129908 KIAA0591 protein 49
431117 AF003522 Hs 250500 delta (Drosophιla)-lιke 1 49
407235 D20569 Hs 169407 SAC2 (suppressor of acdn mutations 2, y 49
417404 NM.007350 Hs 82101 pleckstπn homology like domain, family 49
448548 R13209 Hs 21413 solute earner family 12, (potassium-chl 49
420092 AA814043 Hs 88045 ESTs 49
449571 AW016812 Hs 200266 ESTs 49
412811 H06382 ESTs 49
409100 H98216 Hs 42245 ESTs, Moderately similar to I38022 hypot 49
403142 NM 002706' Homo sapiens protein phosphat 49
414300 AI304870 Hs 188680 ESTs 49
436607 AW661783 Hs 211061 ESTs 49
431553 X78075 Hs 2799 cartilage linking protein 1 49
449328 AI962493 Hs 345303 ESTs 49
420805 L10333 Hs 99947 redculon 1 49
421688 AK000307 Hs 106825 hypothetical protein FU20300 49
452898 AA814497 Hs 78792 ESTs 49
427958 AA418000 Hs 98280 potassium intermediate/small conductance 49
432328 AI572739 Hs 195471 6-phosphofructo-2-kιnase/fructose-2,6-bι 49
408453 AI369838 Hs 45127 chondroidn sulfate proteoglycan 5 (neur 48
428841 AI418430 Hs 104935 ESTs 48
416439 AA180363 Hs 118769 ESTs 48
447458 AI741082 Hs 158961 ESTs 48
429433 AA452899 Hs 213586 ESTs, Weakly similar to KIAA1353 protein 48
409746 NM.004794 Hs 56294 RAB33A, member RAS oncogene family 48
436511 AA721252 Hs 291502 ESTs 48
443392 AI055821 Hs 293420 ESTs 48
423600 AI633559 Hs 310359 ESTs 48
425905 AB032959 Hs 318584 novel C3HC4 type Zinc finger (nng finge 48
414706 AW340125 Hs 76989 KIAA0097 gene product 48
407385 AA610150 Hs 272072 ESTs. Weakly similar to I38022 hypothed 48
439340 AB032436 Hs 6535 brain-specific Na-depeπdent inorganic ph 47
427624 AA406245 Hs 24895 ESTs 47
413248 T64858 Hs 21433 hypothetical protein DKFZp547J036 47
408670 AF160967 Hs 46784 potassium large conductance calcium acd 47
440491 R35252 Hs 130558 ESTs, Weakly similar to 2109260A B cell 47
411555 AF113537 Hs 70669 HMP19 protein 47
430471 AF064845 Hs 241523 hypothedcal protein FU10142 47
413530 AA130158 Hs 19977 ESTs, Moderately similar to ALU8.HUMAN A 47
445900 AF070526 Hs 125036 Homo sapiens clone 24787 mRNA sequence 47
426457 AW894667 Hs 169965 chimenn (chimaenn) 1 47
459527 AW977556 Hs 291735 ESTs, Weakly similar to I78885 senne/th 47
453096 AW294631 Hs 11325 ESTs 47 409125 R17268 Hs 343567 axonal transport of syπapdc vesicles 47
428001 H97428 Hs 219907 ESTs, Moderately similar to Transforming 47
410276 AI554545 Hs 68301 angιopoιetιn-2 47
421637 AF035290 Hs 106300 Homo sapiens done 23556 mRNA sequence 47
421633 AF121860 Hs 106260 sorting nexm 10 47
440052 AI633744 Hs 195648 ESTs, Weakly similar to I38022 hypothed 47
439566 AF086387 gb Homo sapiens full length insert cDNA 47
432890 NM_014442 Hs 279751 sialic acid binding Ig-like lectin 8 46
402145 Target Exon 46
409892 AW956113 Hs 7149 gb EST368183 MAGE resequences, MAGD Homo 46
458760 AI498631 Hs 111334 femdn, light polypepdde 46
453362 H14988 Hs 107375 ESTs 46
436734 AI937612 Hs 273758 hypothedcal protein FU23112 46
426925 NM 001196 Hs 315689 Homo sapiens cDNA FU22373 fis, clone H 46
409041 AB033025 Hs 50081 Hypothedcal protein, XP.051860 (KIAA119 46
428832 AA578229 Hs 324239 ESTs, Moderately similar to ZN91_HUMAN Z 46
423770 AW976766 Hs 132776 Homo sapiens cDNA FU 10077 fis, clone HE 46
410264 AK001853 Hs 61508 Homo sapiens cDNA FU10991 fis. clone PL 46
429149 AW193360 Hs 197962 ESTs, Weakly similar to I38022 hypothed 46
437762 T78028 Hs 154679 synaptotagmin I 46
439249 AF086060 Hs 170053 G-protem coupled receptor 88 46
416426 AA180256 Hs 210473 Homo sapiens cDNA FU14872 fis, clone PL 46
425256 BE297611 Hs 155392 collapsm response mediator protein 1 46
415257 F03016 Hs 27513 ESTs 46
428186 AW504300 Hs 295605 mannosidase, alpha, dass 2A, member 2 46
458814 AI498957 Hs 170861 ESTs, Weakly similar to Z195_HUMAN ZINC 46
451320 AW118072 diacylglycerol kinase, zeta (104kD) 45
424998 U58515 Hs 154138 chidnase 3-lιke 2 45
422709 AA315331 Hs 153485 ESTs 45
420578 AA813546 Hs 99034 GTP-binding protein Rho7 45
421977 W94197 Hs 110165 nbosomal protein 126 homolog 45
457465 AW301344 Hs 122908 DNA replicadon factor 45
427712 AI368024 Hs 283696 ESTs 45
444656 AI277924 Hs 145199 ESTs 45
413409 AI638418 Hs 1440 DEAD/H (Asp-Glu Ala-Asp/His) box polypep 45
429399 AA452244 Hs 16727 ESTs 45
450639 AI703186 Hs 277174 ESTs 45
452106 AI141031 Hs 21342 ESTs 45
424240 AB023185 Hs 143535 calcium/calmodulm-dependent protein k 45
433009 AA761668 gb nz24c08 s1 NCI_CGAP_GCB1 Homo sapiens 45
446657 AI335191 Hs 260702 ESTs, Weakly similar to 2109260A B cell 45
428189 AA424030 Hs 46627 ESTs 45
423178 AI033140 Hs 124983 Homo sapiens mRNA cDNA DKFZp564C142 (fr 45
445133 AW157646 Hs 198689 ESTs 45
418771 AA807881 Hs 25329 ESTs 44
438456 AA913381 Hs 20594 ESTs 44
410386 W26187 Hs 3327 Homo sapiens cDNA FU22219 fis, clone H 44
413834 BE296896 Hs 224179 ESTs, Weakly similar to I38022 hypotheti 44
419103 Z40229 Hs 96423 hypothedcal protein FU23033 44
420560 AW207748 Hs 59115 ESTs 44
439662 H97552 Hs 269060 ESTs 44
408577 H50572 Hs 19515 ESTs, Highly similar to NRG3 HUMAN PRO-N 44
445034 AW293376 Hs 143659 ESTs 44
402605 Target Exon 44
426271 AF026547 Hs 169047 chondroidn sulfate proteoglycan 3 (neur 44
457561 AA331517 Hs 286055 chimeπn (chimaeπn) 2 44
430676 AF084866 gb Homo sapiens envelope protein RIC-3 ( 44
439570 T79925 Hs 269165 ESTs, Weakly similar to ALU1.HUMAN ALU S 44
452752 AW044058 Hs 33578 KIAA0820 protein 44
439108 AW163034 Hs 6467 synaptogynn 3 44
405819 NM.002578 Homo sapiens p21 (CDKNIA)-acd 44
446544 AI631932 Hs 7047 ESTs, Weakly similar to Unknown [H sapie 44
412530 AA766268 Hs 266273 hypothetical protein FU 13346 44
420871 AA702972 Hs 65300 ESTs 44
408622 AA056060 Hs 202577 Homo sapiens cDNA FU 12166 fis, clone MA 44
429269 AA449013 Hs 99203 ESTs 43
427463 AA442224 Hs 97900 ESTs 43
425402 AI215881 Hs 24970 ESTs, Weakly similar to B34323 GTP-bindi 43
412046 Y07847 Hs 73088 RAS-related on chromsome 22 43
427194 AA399018 Hs 250835 ESTs 43
437834 AA769294 Hs 283854 gb nz36g03 s1 NCI CGAP GCB1 Homo sapiens 43
409172 Z99399 Hs 122593 ESTs 43
409953 AA332277 Hs 57691 cadheπn 18, type 2 43
426968 U07616 Hs 173034 amphiphysin (Sdff-Manπ syndrome with br 43
452092 BE245374 Hs 27842 hypothetical protein FU11210 43
438458 AW975186 gb EST387294 MAGE resequences, MAGN Homo 43
446936 H10207 Hs 47314 ESTs 43
433932 AW954599 Hs 169330 neuronal protein 43
424800 AL035588 Hs 153203 MyoD family inhibitor 43
421988 AW450481 Hs 161333 ESTs 43
442832 AW206560 Hs 253569 ESTs 43
416586 D44643 Hs 14144 secreted modular calcium-binding protein 42
408369 R38438 Hs 182575 solute earner family 15 (H"" - transport 42 450530 NM 006668 Hs 25121 cytochrome P450, subfamily 46 (cholester 42
449318 AW236021 Hs 78531 Homo sapiens Similar to RIKEN cDNA 5730 42
438624 AA889055 Hs 123468 ESTs 42
421027 AA761198 Hs 55254 ESTs 42
417632 R20855 Hs 5422 glycoprotein M6B 42
419412 AW161058 Hs 90297 synuclein, beta 42
430228 AW950939 Hs 6382 ESTs, Highly similar to T00391 hypothed 42
450813 AI739625 Hs 203376 ESTs 42
412505 AA974491 Hs 21734 ESTs 42
440168 AA868507 Hs 126141 ESTs 42
441707 R42637 Hs 21963 hypothedcal protein DKFZp761B0514 42
438703 AI803373 Hs 31599 ESTs 42
444127 N63620 Hs 13281 ESTs 42
447397 BE247676 Hs 18442 E-1 enzyme 42
445523 Z30118 Hs 293788 ESTs, Moderately similar to unnamed prot 42
415079 R43179 Hs 22895 hypothedcal prote FU23548 42
416871 H98716 gb yx13d08 s1 Soares melanocyte 2NbHM Ho 42
408838 AI669535 Hs 40369 ESTs 42
425287 R88249 Hs 155524 peanut (Drosophιla)-lιke 2 42
404584 Target Exon 42
436035 AA703679 Hs 106999 ESTs, Weakly similar to SYT5 HUMAN SYNAP 42
409091 AW970386 Hs 269423 ESTs 42
437117 AL049256 Hs 122593 ESTs 42
429643 AA455889 Hs 167279 FYVE-finger-containing Rab5 effector pro 42
439231 AW581935 Hs 141480 Homo sapiens mRNA cDNA DKFZp434N079 (fr 42
408177 AI241733 Hs 43871 ESTs 42
438875 AA827640 Hs 189059 ESTs 42
447877 AI435184 Hs 164252 ESTs 42
415402 AA164687 Hs 177576 mannosyl (alpha- 1,3-)-glycoproteιn beta- 42
434859 BE255080 Hs 299315 collaps response mediator proteιn-5, C 42
449714 AB033015 Hs 23941 KIAA1189 protein 42
427315 AA179949 Hs 175563 Homo sapiens mRNA, cDNA DKFZp564N0763 (f 42
404541 NM.030795 Homo sapiens stathmin-like 4 ( 4 1
449969 AW295142 Hs 180187 Homo sapiens cDNA FU14337 fis, clone PL 4 1
422374 AW732869 Hs 1519 protein kinase, cAMP-dependenL regulato 4 1
422253 W81526 Hs 118329 ESTs, Moderately similar to GAD_HUMAN GA 41
440483 AI200836 Hs 150386 ESTs 4 1
429421 AL031658 Human DNA sequence from clone RP1 -310013 4 1
432882 NM 013257 Hs 279696 serum/glucocorticoid regulated kmase-li 4 1
424001 W67883 Hs 137476 paternally expressed 10 4 1
422170 AI791949 Hs 112432 and Mullenan hormone 4 1
445292 AV653264 Hs 13982 Homo sapiens cDNA FU 14666 fis clone NT 41
450407 NM 000810 Hs 24969 gamma-aminobutync acid (GABA) A recepto 4 1
429401 AW296102 Hs 99272 ESTs, Weakly similar to S32567 A4 protei 4 1
408950 AA707814 Hs 14945 long fatty acyl-CoA synthetase 2 gene 41
415796 R87548 Hs 78854 ATPase, Na9 transporting beta 2 polypep 4 1
446619 AU076643 Hs 313 secreted phosphoprotein 1 (osteopondn, 4 1
457211 AW972565 Hs 32399 ESTs Weakly similar to S51797 vasodilat 41
416547 H62914 Hs 268946 ESTs, Weakly similar to PC4259 femdn 4 1
412777 AI335773 Hs 270123 ESTs 41
445225 AI216555 Hs 202398 ESTs 4 1
408926 AF217525 Hs 49002 Down syndrome cell adhesion molecule 4 1
417873 BE266659 Hs 293659 Homo sapiens, Similar to RIKEN cDNA A430 41
443301 AI733614 Hs 220587 ESTs, Moderately similar to ALU5_HUMAN A 4 1
429281 AA830856 Hs 29808 Homo sapiens cDNA FU21122 fis, clone C 4 1
448966 AW372914 Hs 86149 phosphoinositol 3-phosphate-bιndιng prot 4 1
453857 AL080235 Hs 35861 DKFZP586E1621 protein 41
417355 D13168 Hs 82002 endothelin receptor type B 4 1
410359 R38624 Hs 106313 ESTs 41
426529 AF090100 Hs 170241 Homo sapiens clone IMAGE 23915 4 1
433323 AA805132 Hs 159142 ESTs 4 1
434933 R91095 Hs 4276 KIAA1701 protein 41
453331 AI240665 ESTs 4 1
422661 NM 014700 Hs 119004 KIAA0665 gene product 4 1
424726 AK001007 Hs 138760 Homo sapiens cDNA FU10145 fis, clone HE 40
416805 F13271 Hs 79981 Human clone 23560 mRNA sequence 40
441797 AI936933 Hs 214635 ESTs 40
424282 R76421 Hs 135694 ESTs 40
407792 AI077715 Hs 39384 putadve secreted ligand homologous to f 40
425390 AI092634 Hs 156114 protein tyrosine phosphatase, non-recept 40
435312 AJ243396 Hs 4865 voltage-gated sodium channel beta-3 subu 40
424635 AA420687 Hs 115455 Homo sapiens cDNA FU14259 fis, clone PL 40
423279 AW959861 Hs 290943 ESTs 40
444001 AI095087 Hs 152299 ESTs, Moderately similar to S65657 alpha 40
410768 AF038185 Hs 66187 Homo sapiens clone 23700 mRNA sequence 40
426413 AA377823 gb EST90805 Synovial sarcoma Homo sapien 40
450581 AF081513 Hs 25195 TGF-beta 4 40
435854 AJ278120 Hs 4996 putative ankyπn-repeat containing prote 40
433615 AA732982 Hs 269607 ESTs, Weakly similar to ALU1.HUMAN ALU S 40
432058 AW665996 Hs 130729 ESTs, Weakly similar to ALU1_HUMAN ALU S 40
439774 AL360257 Hs 213493 Homo sapiens mRNA full length insert cDN 40
445666 R59960 Hs 282386 ESTs 40
450582 AI339732 G-πch RNA sequence binding factor 1 40 437814 AI088192 Hs 135474 ESTs, Weakly similar to DDX9_HUMAN ATP-D 40
451468 AW503398 Hs 293663 ESTs, Moderately similar to I38022 hypot 40
449277 AA001064 Hs 43670 ESTs 40
440553 AA889416 Hs 344043 Homo sapiens cDNA FU14459 fis, clone HE 40
445888 AF070564 Hs 13415 Homo sapiens clone 24571 mRNA sequence 40
420111 AA255652 gb zs21h11 r1 NCI_CGAP_GCB1 Homo sapiens 40
407198 H91679 gb yv04a07 s1 Soares fetal liver spleen 40
422564 AI148006 Hs 222120 ESTs 40
443992 AW022228 Hs 322922 ESTs 40
435542 AA687376 ESTs 40
444153 AK001610 Hs 10414 hypothedcal protein FU10748 40
437748 AF234882 Hs 5814 suppression of tumongenicity 7 40
439285 AL133916 hypothedcal protein FU20093 40
449655 AI021987 Hs 59970 ESTs 40
458435 AI418718 Hs 144121 ESTs, Weakly similar to T46916 hypotheti 40
412659 AW753865 Hs 74376 olfadomed related ER localized protei 40
423905 AW579960 Hs 135150 lung type-l cell membrane-associated gly 40
432683 AW995441 Hs 10475 ESTs 40
410765 AI694972 Hs 66180 πucleosome assembly protein 1-lιke 2 40
420649 AI866964 Hs 124704 ESTs, Moderately similar to S65657 alpha 40
450927 AI807804 Hs 134342 TASP for tesds-specific adnamycin sens 40
448985 AA324885 Hs 22777 carbonic anhydrase XI 40
416406 D86961 Hs 79299 lipoma HMGIC fusion partner-like 2 40
412754 AW160375 Hs 74565 amyloid beta (A4) precursor-like protein 39
416340 N31772 Hs 79226 fasciculation and elongadon protein zet 39
428862 NM 000346 Hs 2316 SRY (sex determining region Y)-box 9 (ca 39
413554 AA319146 Hs 75426 secretogranin II (chromogranin C) 39
419687 AI638859 Hs 227699 ESTs, Weakly similar to T2D3 HUMAN TRANS 39
453438 AI469935 Hs 22792 ESTs 39
410082 AA081594 Hs 158311 Musashi (Drosophila) homolog 1 39
424736 AF230877 Hs 152701 microtubule-interacting protein that ass 39
412326 R07566 Hs 73817 small inducible cytokine A3 (homologous 39
411666 AF106564 Hs 71346 neurofilament 3 (150kD medium) 39
439935 S75105 Hs 8358 glutamate receptor, lonotroptc, kainate 39
459278 AW294659 Hs 34054 Homo sapiens cDNA FU22488 fis clone H 39
432809 AA565509 Hs 131703 ESTs 39
450568 AL050078 Hs 25159 Homo sapiens cDNA FU10784 fis, clone NT 39
413951 AW051200 Hs 75640 natπuredc pepdde precursor A 39
435743 T66861 Hs 12962 ESTs 39
447937 AL109716 Hs 20034 Homo sapiens mRNA full length insert cDN 39
417576 AA339449 Hs 82285 phosphoπbosylglycinamide formyltransfer 39
448526 AB028946 Hs 21361 KIAA1023 protein 39
445890 AF055019 Hs 21906 Homo sapiens clone 24670 mRNA sequence 39
425241 AA324624 Hs 155247 aldolase C, fructose-bisphosphate 38
417333 AL157545 Hs 173179 bromodomain and PHD finger containing, 3 38
435832 AA425688 Hs 41641 Bruno (Drosophila) -like 4, RNA binding 38
410592 R94088 Hs 43569 ESTs 38
443361 AI792628 Hs 133273 ESTs 38
403696 C4001100* gι|5852342|gb|AAD54015 1| (AF0 38
437756 AA767537 Hs 197096 ESTs 38
433675 AW977653 Hs 75319 πbonucleodde reductase M2 polypepdde 38
414998 NM 002543 Hs 77729 oxidised low density lipoprotein (lecdn 38
425652 AB021742 Hs 322431 neurogenic differentiation 2 38
437449 AL390153 Hs 208339 Homo sapiens mRNA, cDNA DKFZp762G113 (fr 38
421040 AA715026 Hs 135280 ESTs 38
454171 AW854832 gb QV2-CT0261-201099-011-f05 CT0261 Homo 38
443740 R56434 Hs 21062 ESTs 38
441668 AI611973 Hs 136313 ESTs 38
423175 W27595 Hs 347310 hypothetical protein FU14627 38
457183 H91882 Hs 118569 Dvl-binding protein IDAX (inhibition of 38
438142 T90309 Hs 269651 ESTs 38
408875 NM_015434 Hs 48604 DKFZP434B168 protein 38
436899 AA764852 Hs 291567 ESTs 38
456497 AW967956 Hs 123648 ESTs Weakly similar to AF108460 1 ubinu 38
416892 L24498 Hs 80409 growth arrest and DNA-damage-inducible, 38
413199 M62843 Hs 75236 ELAV (embryonic lethal, abnormal vision, 38
410711 AB002316 Hs 65746 KIAA0318 protein 38
454117 BE410100 Hs 40368 adaptor-related protein complex 1, sigma 38
438944 AA302517 Hs 92732 KIAA1444 protein 38
445078 AI869975 HS 4775 junctophilin 3 38
424330 AW073953 Hs 333396 Homo sapiens cDNA FU13596 fis, clone PL 38
439099 AB037800 Hs 6462 protein kinase C and casein kinase subst 38
449444 AW818436 Hs 23590 solute earner family 16 (monocarboxylic 38
411252 AB018549 Hs 69328 MD-2 protein 37
448275 BE514434 Hs 20830 kinesm-like 2 37
434269 AK001991 Hs 3781 similar to muπne leucine-nch repeat pr 37
400777 NM_007325* Homo sapiens glutamate recept 37
419586 AI088485 Hs 144759 ESTs, Weakly similar to I38022 hypothed 37
458072 AI890347 Hs 271923 Homo sapiens cDNA FU22785 fis, clone K 37
445908 R13580 Hs 13436 Homo sapiens clone 24425 mRNA sequence 37
448451 AW015994 Hs 345433 gb UI-H-BIOp-abh-g-09-O-UI s1 NCI CGAP S 37
430183 BE010038 gb PM3-BN0176-100400-001-g04 BN0176 Homo 37
430147 R60704 Hs 234434 hairγ/enhancer-of-split related with YRP 37 458912 AI911066 ESTs 37
428110 AI312485 Hs 138294 ESTs, Moderately similar to Z195.HUMAN Z 37
448048 BE281291 Hs 170408 ESTs, Moderately similar to A47582 B-cel 37
442326 H92962 Hs 124813 hypothedcal protein MGC14817 37
422798 R92347 Hs 34574 ESTs, Weakly similar to ALU 1. HUMAN ALU S 37
428873 AI701609 Hs 98908 ESTs 37
438208 AL041224 Hs 65379 ESTs 37
414040 N58513 Hs 32171 ESTs 37
407846 AA426202 Hs 40403 Cbp/ρ300-ιnteracdng transacdvator, wit 37
408829 NM 006042 Hs 8384 heparan sulfate (glucosamine) 3-O-sulfot 37
425010 T16837 Hs 4241 ESTs 37
427209 H06509 Hs 92423 KIAA1566 protein 37
407603 AW955705 Hs 62604 Homo sapiens, clone IMAGE 4299322, mRNA, 36
410126 BE169274 KIAA0036 gene product 36
426646 AA382787 Hs 122713 ESTs 36
418329 AW247430 Hs 84152 cystathionme-beta-synthase 36
419390 AI701162 Hs 90207 hypothedcal protein MGC11138 36
441703 AW390054 Hs 192843 leucine zipper protein FKSG14 36
431725 X65724 Hs 2839 Nome disease (pseudoglioma) 36
448425 AI500359 Hs 346112 ESTs 36
423611 AB011163 Hs 129908 KIAA0591 protein 36
438831 BE263273 Hs 6439 synapsm II 36
419235 AW470411 Hs 288433 neurotπmm 36
451027 AW519204 Hs 40808 ESTs 36
428483 AI908539 Hs 184592 KIAA0344 gene product 36
424947 R77952 ESTs, Weakly similar to altemadvely sp 36
404150 Target Exon 36
450297 AW901347 Hs 38592 hypothedcal protein FU 23342 36
443715 AI583187 Hs 9700 cyclin E1 36
435910 AI084152 Hs 21782 ESTs, Weakly similar to ALU7.HUMAN ALU S 36
418064 BE387287 Hs 83384 S100 calcium-binding protein, beta (neur 36
432488 AA551010 Hs 216640 ESTs 36
431342 AW971018 Hs 21659 ESTs 36
437916 BE566249 Hs 20999 hypothedcal protein FU23142 36
412043 BE156622 Hs 333371 Homo sapiens clone TA40 untranslated mRN 36
448448 NM.014954 Hs 21239 KIAA0985 protein 36
447818 W79940 Hs 21906 Homo sapiens clone 24670 mRNA sequence 36
445105 AF238869 Hs 283955 Homo sapiens clone GLSH-2 similar to gli 36
409557 BE182896 Hs 211193 ESTs 36
425202 AW962282 Hs 152049 ESTs, Weakly similar to I38022 hypothed 36
451734 NM.006176 Hs 26944 neurogranin (protein kinase C substrate, 36
425331 AW962128 gb EST374201 MAGE resequences MAGG Homo 36
412799 AI267606 gb aq91h03 x1 Stanley Frontal SB pool 1 36
435040 AI932350 Hs 152825 ESTs 36
434149 Z43829 Hs 244624 hypothedcal protein MGC5469 36
415709 AA649850 Hs 278558 ESTs 36
424051 AL110203 Hs 138411 Homo sapiens mRNA, cDNA DKFZp586J1922 (f 36
437640 AA764893 Hs 272155 ESTs, Weakly similar to I38022 hypotheti 36
445953 AI612775 Hs 145710 ESTs 36
449256 AA059050 Hs 59847 ESTs 36
424687 J05070 Hs 151738 madix metalloproteinase 9 (geladnase B 36
409327 L41162 Hs 53563 collagen, type IX, alpha 3 36
417675 AI808607 Hs 3781 similar to muπne leucine πch repeat pr 36
423641 AL137256 Hs 130489 ATPase, aminophospholipid transporter Ii 36
443912 R37257 Hs 184780 ESTs 36
424572 M19650 2,3-cyclιc nucleotide 3' phosphodieste 35
424899 AL119387 Hs 119062 ESTs 35
439726 AW449893 Hs 293707 ESTs, Weakly similar to I38598 zinc fing 35
416490 AF090116 Hs 79348 regulator of G-protem signalling 7 35
458809 AW972512 Hs 20985 sιn3-assocιated polypepdde, 30kD 35
429084 AJ001443 Hs 195614 splicing factor 3b, subunit 3, 130kD 35
407624 AW157431 Hs 248941 ESTs 35
419038 AW134924 Hs 190325 ESTs 35
451489 NM 005503 Hs 26468 amyloid beta (A4) precursor protein-bind 35
428242 H55~709 Hs 2250 leukemia inhibitory factor (cholinergic 35
411048 AK001742 Hs 67991 hypothetical protein DKFZp434G0522 35
435575 AF213457 Hs 44234 tnggenng receptor expressed on myeloid 35
424340 AA339036 Hs 7033 ESTs 35
425790 AW136286 Hs 288446 ESTs 35
432188 AI362952 Hs 2928 solute earner family 7 (cationic ammo 35
453896 AW293483 Hs 255205 KIAA1853 protein 35
434784 AA649051 Hs 164007 ESTs 35
452449 AW068658 Hs 20943 ESTs 35
425212 AW962253 Hs 171618 ESTs 35
407253 AA411175 Hs 141939 ESTs, Moderately similar to S65657 alpha 35
418049 AA211467 Hs 190488 Homo sapiens. Similar to nuclear locale 35
421247 BE391727 Hs 102910 general transcnpdon factor IIH, polype 35
459311 R40192 Hs 21527 Human DNA sequence from clone GS1-115M3 35
439450 R51613 Hs 125304 ESTs 35
435545 AA687415 Hs 28107 ESTs 35
445729 H21066 Hs 13223 Homo sapiens mRNA full length insert cDN 35
448999 AF179274 Hs 22791 transmembrane protein with EGF-dke and 35
412590 AL134388 Hs 135033 ESTs, Weakly similar to I38022 hypotheti 35 438527 AI969251 Hs 115325 RAB7, member RAS oncogene family-like 1 35
441111 AI806867 Hs 126594 ESTs 35
418630 AI351311 Hs 251946 poly(A)-bιndιng protein, cytoplasmic 1-1 35
439920 H05430 Hs 288433 neurotπmin 35
421268 AI126821 Hs 30514 ESTs 35
432022 AL162042 Hs 272348 Homo sapiens mRNA, cDNA DKFZp761L1212 (f 35
412719 AW016610 Hs 816 ESTs 35
435092 AL137310 Hs 4749 Homo sapiens mRNA. cDNA DKFZp761E13121 ( 35
414178 AW957372 Hs 46791 ESTs, Weakly similar to I38022 hypothed 35
437252 AI433833 Hs 164159 ESTs, Weakly similar to ALU1.HUMAN ALU S 35
452108 AW135982 Hs 203013 hypothetical protein FU 12748 34
421183 AL135740 Hs 102447 TSC-22-lιke 34
441834 AL138034 Hs 7979 KIAA0736 gene product 34
413812 AW188687 Hs 44748 ESTs 34
449932 AI675444 Hs 263024 ESTs 34
447067 R42098 Hs 21964 ESTs 34
408296 AL117452 Hs 44155 DKFZP586G1517 protein 34
447028 AI973128 Hs 167257 brain link protein- 1 34
432715 AA247152 Hs 200483 ESTs, Weakly similar to KIAA1074 protein 34
418358 L02840 Hs 84244 potassium voltage-gated channel, Shab-re 34
417084 H08370 Hs 33067 ESTs 34
444534 AW271626 Hs 42294 ESTs 34
440700 AW952281 Hs 296184 guanine nucleodde binding protein (G pr 34
436637 AI783629 Hs 26766 ESTs 34
412820 BE001236 gb CM3-BN0075-240200-101-d11 BN0075 Homo 34
428138 AA773842 Hs 293799 ESTs 34
453033 AA325869 Hs 31463 KIAA0281 gene product 34
453305 R39224 Hs 267997 EHM2 gene 34
459660 M79082 ESTs 34
418821 AA436002 Hs 183161 ESTs 34
439518 W76326 gb zd60d04 r1 Soares_fetal.heart_NbHH19W 34
400379 NM_018432 Homo sapiens ovarian cancer related prot 34
437085 AA743935 Hs 202329 ESTs 34
419852 AW503756 Hs 286184 hypothedcal protein dJ551D25 34
430694 AA810624 Hs 30936 ESTs, Weakly similar to H2BH_HUMAN HISTO 34
441287 AW293132 Hs 131373 ESTs 34
425870 R13406 Hs 56782 ESTs 34
443672 AA323362 Hs 9667 butyrobetame (gamma), 2-oxoglutarate di 34
448044 AI458682 gb tk13e01 x1 NCI_CGAP_Lu24 Homo sapiens 34
405238 Target Exon 34
440404 AI015881 Hs 324527 mitochondπal πbosomal protein S5 34
453590 AF150278 Hs 33578 KIAA0820 protein 34
450756 AI733488 Hs 144062 ESTs 34
404283 ENSP00000244751' Copine-like protein KIA 34
423257 AW161039 Hs 125878 synapsm III 34
432149 AW614326 Hs 133483 ESTs, Weakly similar to T34549 probable 34
412986 X81120 Hs 75110 cannabinoid receptor 1 (brain) 34
422809 AK001379 Hs 121028 hypothetical protein FU10549 34
420050 AL118615 Hs 94653 neurochondπn 34
431789 H19500 Hs 269222 mitogen-xdvated protein kinase 4 34
408601 U47928 Hs 86122 protein A 34
453740 AL120295 Hs 311809 ESTs, Moderately similar to PC4259 fem 34
449919 AI674685 Hs 200141 ESTs 34
426380 AI291267 Hs 149990 ESTs 34
408554 AA836381 Hs 315111 nuclear receptor co-repressor/HDAC3 comp 33
443257 AI334040 Hs 11614 HSPC065 protein 33
432731 R31178 Hs 287820 fibronectin 1 33
421679 AI475110 Hs 203933 ESTs 33
453169 AB037815 Hs 32156 KIAA1394 protein 33
437397 AA349847 Hs 4221 hypothetical protein DKFZp761H039 33
443310 BE552018 Hs 133152 ESTs 33
423169 BE047009 Hs 21837 ESTs, Weakly similar to KIAA0927 protein 33
433657 AI244368 Hs 8124 PH domain containing protein in redna 1 33
408449 NM 004408 Hs 166161 dynamin 1 33
417402 BE503227 Hs 134759 ESTs 33
416677 T83470 Hs 334840 ESTs, Moderately similar to I78885 seπn 33
439753 BE262233 Hs 7423 hypothetical protein from EUROIMAGE 2168 33
455646 BE064420 gb RC4-BT0311-241199-012-c08 BT0311 Homo 33
450337 AI693256 Hs 202427 ESTs 33
423420 AI571364 Hs 128382 Homo sapiens mRNA cDNA DKFZp761M224 (f 33
433236 NM_004296 Hs 3221 regulator of G-protem signalling 6 33
417868 AI078534 Hs 122592 ESTs 33
436207 AA334774 Hs 12845 hypothedcal protein MGC13159 33
441607 NM 005010 Hs 7912 neuronal cell adhesion molecule 33
449249 T52285 Hs 193115 Homo sapiens mRNA for KIAA1764 protein, 33
418216 AA662240 Hs 283099 AF15q1 protein 33
456060 C14904 Hs 45184 Homo sapiens cDNA FU12284 fis, clone MA 33
449145 AI632122 Hs 198408 ESTs 33
415101 R45531 Hs 144534 ESTs 33
401272 C9000559* gι|12314195|emb|CAB99338 1| (A 33
420297 AI628272 Hs 88323 ESTs, Weakly similar to ALU1.HUMAN ALU S 33
419991 AJ000098 Hs 94210 eyes absent (Drosophila) homolog 1 33
443761 AI525743 Hs 345187 ESTs 33 427317 AB028955 Hs 175780 KIAA1032 protein 33
426920 AA393351 Hs 132121 ESTs 33
433894 AI907682 Hs 243293 ESTs 33
454253 AV660717 Hs 47144 DKFZP586N0819 protein 33
419647 AA348947 Hs 91816 hypothedcal protein 33
439978 BE139460 Hs 124673 Homo sapiens cDNA FU11477 fis, clone HE 33
407881 AW072003 Hs 40968 heparan sulfate (glucosamme) 3-O-sulfot 33
428670 AA431682 Hs 134832 ESTs 33
435375 AI733610 Hs 187832 ESTs 33
419043 T19167 Hs 89566 ets vanant gene 1 33
403341 Target Exon 33
436282 R91913 Hs 272104 ESTs, Moderately similar to ALU1_HUMAN A 33
439627 BE621702 Hs 29076 hypothedcal protein FU21841 33
456209 W60633 Hs 297792 ESTs 33
438810 AW897846 Hs 6421 hypothetical protein DKFZp761N09121 33
411565 AW851728 gb MR2-CT0222-011199-007-d06 CT0222 Homo 33
418203 X54942 Hs 83758 CDC28 protein kinase 2 33
451254 AI571016 Hs 172967 ESTs 33
435056 AW023337 Hs 5422 glycoprotein M6B 33
433842 AI652156 Hs 26346 ESTs 33
433325 AW206986 Hs 143905 ESTs 33
451066 AI758660 Hs 206132 ESTs 33
436114 AA778232 Hs 19515 ESTs, Highly similar to NRG3_HUMAN PRO-N 33
421686 AB011156 Hs 106794 KIAA0584 protein 33
429228 AI553633 Hs 326447 ESTs 33
450325 AI935962 Hs 26289 ESTs 33
412350 AI659306 Hs 73826 protein tyrosine phosphatase, non-recept 33
451778 AI826131 Hs 62954 ESTs, Weakly similar to zinc finger prot 33
435977 AL138079 Hs 5012 bran-specific membrane-anchored protein 32
450475 AW805634 Hs 205015 ESTs 32
418661 NM 001949 Hs 1189 E2F transcnpdon factor 3 32
436480 AJ271643 Hs 87469 putative acid-sensing ion channel 32
407332 AI801565 Hs 200113 Homo sapiens cDNA FU11379 fis, clone HE 32
415131 D61119 gb HUM158C11 B Clontech human fetal brain 32
409248 AB033035 Hs 51965 KIAA1209 protein 32
431462 AW583672 Hs 256311 gramn-like neuroendocnne pepbde precu 32
434834 AF156774 Hs 324020 1-acylglycerol-3-phosphate O-acyltransfe 32
450358 AB010098 Hs 24907 coronin, actin-bindmg protein, 2B 32
438461 AW075485 Hs 286049 phosphoseπne aminotransferase 32
405239 U89281 oxidadve 3 alpha hydroxysteroid dehydro 32
407304 AA565832 Hs 271649 gb πj32b03 s1 NCI_CGAP_AA1 Homo sapiens 32
451697 AW449774 Hs 296380 POM (POM121 rat homolog) and ZP3 fusion 32
435071 D60683 Hs 35495 ESTs 32
420352 BE258835 gb 601117374F1 NIH MGC 16 Homo sapiens c 32
412193 AI684467 Hs 144057 ESTs 32
442320 AI287817 Hs 129636 ESTs 32
407378 AA299264 Hs 57776 ESTs, Moderately similar to I38022 hypot 32
414528 AA148950 Hs 188836 ESTs 32
439764 T26535 Hs 22744 hypothetical protein MGC13105 32
410425 BE278367 Hs 63510 KIAA0141 gene product 32
429876 AB028977 Hs 225974 KIAA1054 protein 32
427627 R87582 Hs 179915 guanine nucleodde binding protein (G pr 32
439039 AI656707 Hs 48713 ESTs 32
447925 AW292271 Hs 250718 ESTs 32
447714 AW296313 Hs 255537 ESTs 32
434574 AI424458 Hs 33470 ESTs 32
437269 AA334384 Hs 149420 ESTs 32
416845 H95279 Hs 293788 gb yu20h02 s1 Soares fetal liver spleen 32
452234 AW084176 Hs 223296 ESTs, Weakly similar to I38022 hypothed 32
440274 R24595 Hs 7122 scrapie responsive protein 1 32
437698 R61837 Hs 7990 ESTs, Moderately similar to I84505 calci 32
414761 AU077228 Hs 77256 enhancer of zeste (Drosophila) homolog 2 32
445828 F05802 Hs 81907 ESTs 32
423779 AW071837 Hs 57971 ESTs 32
403790 NM 001334* Homo sapiens cathepsin O (CTS 32
453792 AL134539 Hs 254129 KIAA1678 32
428167 AA770021 Hs 16332 ESTs 32
445413 AA151342 Hs 12677 CGI- 147 protein 32
415314 N88802 Hs 5422 glycoprotein M6B 32
425115 R44664 Hs 123956 ESTs 32
432625 AI243596 Hs 94830 ESTs, Moderately similar to T03094 A-kin 32
412420 AL035668 Hs 73853 bone morphogenedc protein 2 31
422772 AL119585 Hs 120228 KIAA0749 protein 3 1
437414 AW894071 Hs 48448 hypothedcal protein DKFZp547C176 3 1
427961 AW293165 Hs 143134 ESTs 31
435256 AF193766 Hs 13872 cytokine-like protein C17 3 1
428966 AF059214 Hs 194687 cholesterol 25-hydroxylase 3 1
413995 BE048146 Hs 75671 syntaxin 1A (brain) 31
443431 AI056847 Hs 20654 ESTs 3 1
414217 AI309298 Hs 279898 Homo sapiens cDNA FU23165 fis, clone L 3 1
419617 AL008583 Hs 91622 neuronal pentraxin receptor 3 1
444326 AI939357 Hs 270710 ESTs 3 1
436315 BE390513 Hs 27935 hypothedcal protein MGC4837 3 1 446131 NM 000929 Hs 290 phospholipase A2. group V 31
423858 AL137326 Hs 133483 Homo sapiens mRNA, cDNA DKFZp434B0650 (f 3 1
448475 BE613134 Hs 247474 hypothedcal protein FU21032 3 1
432682 AI376400 Hs 159588 ESTs 31
450661 AW952160 Hs 83849 ESTs 31
417636 R08916 Hs 191212 ESTs 31
417918 AA209205 Hs 163754 hypothedcal protein FU 12606 3 1
454032 W31790 Hs 194293 ESTs, Weak-y similar to 154374 gene NF2 3 1
443150 AI034467 Hs 34650 ESTs 3 1
404632 NMJ322490 Homo sapiens hypothedcal prot 3 1
425537 AB007913 Hs 158291 KIAA0444 protein 3 1
437162 AW005505 Hs 5464 thyroid hormone receptor coacdvadng pr 3 1
400090 Eos Control 3 1
445424 AB028945 Hs 12696 cortacdn SH3 domain-binding protein 3 1
422949 AA319435 gb EST21657 Adrenal gland tumor Homo sap 31
448750 U95020 Hs 21903 calcium channel, voltage-dependent, beta 31
433560 AI925195 Hs 130891 hypothetical protein MGC4400 3 1
433042 AW193534 Hs 281895 Homo sapiens cDNA FU11660 fis, clone HE 31
449722 BE280074 Hs 23960 cyclin B1 31
425480 AB023198 Hs 158135 KIAA0981 protein 31
449670 F07693 Hs 85603 Homo sapiens mRNA, cDNA DKFZp434K2172 (f 31
452619 AW298597 Hs 61884 Homo sapiens, clone IMAGE 4298026, mRNA, 31
428722 U76456 Hs 190787 tissue inhibitor of metalloproteinase 4 3 1
405605 C2001342 gι|127814|sp|P26434|NAH4 RAT SO 3 1
417565 AI203405 Hs 47831 ESTs 31
439538 AA837323 Hs 56407 ESTs 3 1
414117 W88559 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbac 3 1
430818 AI311928 Hs 348156 gb qo89h04 x1 NCI_CGAP_Kιd5 Homo sapiens 31
408508 AI806109 Hs 135736 KIAA1580 protein 31
414884 R54418 Hs 183745 hypothedcal protein FU13456 3 1
439963 AW247529 Hs 6793 platelet-acdvadng factor acetylhydrola 3 1
446636 AC002563 Hs 15767 citron (rho-interacdng, senne/threonin 31
417169 R13550 Hs 246773 ESTs 3 1
450202 AW969756 Hs 34145 ESTs, Weakly similar to B49647 GTP-bindi 3 1
428060 AA420616 Hs 249483 ESTs 31
430526 AF181862 Hs 242407 G protein-coupled receptor, family C, gr 3 1
421458 NM 003654 Hs 104576 carbohydrate (keratan sulfate Gal-6) sul 31
429163 AA884766 gb am20a10 s1 Soares.NFL_T_GBC.S1 Homo s 30
428180 AI129767 Hs 182874 guanine nucleotide binding protein (G pr 30
422631 BE218919 Hs 118793 hypothetical protein FU 10688 30
433290 R20077 Hs 302185 Homo sapiens clone 23618 mRNA sequence 30
412507 L36645 Hs 73964 EphA4 30
415827 H17462 Hs 23079 ESTs 30
429609 AF002246 Hs 210863 cell adhesion molecule with homology to 30
457358 AI479755 Hs 129010 ESTs 30
441732 AW298818 Hs 127341 ESTs 30
459318 NM 000038 gb Homo sapiens adenomatosis polyposis c 30
426384 AI472078 Hs.303662 hypothedcal protein FLJ13189 (FU13189) 30
436267 AW450938 Hs 180115 ESTs 30
450650 T65617 Hs 101257 hypothedcal protein MGC3295 30
414865 AA157155 Hs 274414 hypothedcal protein FU14457 30
459080 AW192083 Hs 290855 ESTs 30
412783 BE276738 Hs 74578 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 30
432593 AW301003 Hs 51483 ESTs, Weakly similar to hypothedcal pro 30
443753 AW367578 Hs 134749 ESTs 30
445921 AW015211 Hs 146181 ESTs 30
427695 R88483 Hs 172862 ESTs 30
438283 AI458931 Hs 37282 ESTs 30
453324 W26592 Hs 232089 ESTs 30
421094 AW978202 Hs 289064 hypothedcal protein FU22251 30
433434 AA588429 gb no22b03 si NCI.CGAP.Pr22 Homo sapiens 30
452850 H23230 Hs 22481 ESTs, Moderately similar to A46010 X-lin 30
416658 U03272 Hs 79432 fibπllin 2 (congenital contractural ara 30
429569 AA454993 Hs 138343 ESTs, Weakly similar to I78885 senne/th 30
428600 AW863261 Hs 242413 hypothetical protein DKFZp434K1421 30
443633 AL031290 Hs 9654 similar to pregnancy-associated plasma p 30
433229 AB040925 Hs 91625 KIAA1492 protein 30
429046 X57436 Hs 194772 oligodendrocyte myelin glycoprotein 30
431431 AL096711 Hs 252953 Human DNA sequence from clone RP3-403A15 30
414430 AI346201 Hs 76118 ubiquitin carboxyl-terminal esterase L1 30
423165 AI937547 Hs 124915 hypothetical protein MGC2601 30
440261 M81886 HS 7117 glutamate receptor, lonotropic AMPA 1 30
441364 AW450466 Hs 126830 ESTs Weakly similar to YD38 YEAST HYPOT 30
437056 AI147061 gb 0k33a11 s1 Soares_NSF_F8_9W_OT_PA_P_S 30
429168 AA984682 Hs 146589 ESTs, Weakly similar to JC5238 gatactosy 30
453739 AL120266 ESTs 30
TABLE 15B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession 410099 117647.1 AA081630 T08671 AI174254 D83874 AW959843 AA364503 AA693467 AW993370 BE327037 AA167714 N79906 AW901977 AW901980 W52882
T07735 AA484549 W60090 D52685 T23811 BE327043 AW901768 BE551237 AA917004 AA716027 AI439658 AA283724 AI805992 AI457096
AA084618 BE467736 AI092635 AI887863 AI697593 AA436618 AI167419 AI418634 T31586 AA436630 AA706191 AI041169 AI422304 T03534
AA211402 AI204899 AI366472 AW827081 AA788593 T32736 AI767935 AA167791 AA747914 AA663870 AI865504
410126 117761 1 BE169274 AW893230 AA210998 H24222 AA081774 BE000935 BE000834 AA334880
411565 12497561 AW851728 AW851607 AW851621 AW851702 AW851647 AW851727 AW851658 AW851617 AW851628
412799 132817.1 AI267606 AA121045 AA126521
412811 132943.1 H06382 AW957730 AA352014 R13591 AA121201 D60420 BE263253 BE047862 Z41952 AI424991 AI693507 AI863108 AA599060 AI091148 AA598689
R39887 AA813482 AW016452 H06383 R41807 AI364268 AA620528 AI241940 AW089149 AW090733 AW088875 Z38240 AA121202 R17734
412820 1330039.1 BE001236 BE001177 BE001180 BE001234
414372 1439091 AA143654 AW753140 AA213770 AW970865 AA569075 AA492132
415131 1523680.1 D61119 D81508 D81734
416871 16267611 H98716 N90792 N24283
418512 176394.1 AW498974 T09332 R58460 AA350990 T33786 T30936 AA350905 T08592 T09274 AA224297 D54678 T08951 R15346 AW953188 AA350 74
AW890649
419544 1857602 AI909154 AA526337 AA244193 AI909153
420111 1907551 AA255652 AA280911 AW967920 AA262684
420352 1929791 BE258835 AW968316 AA258918 AW843305 R14744 AI580388 BE071923 R36280
422949 2231841 AA319435 N56456 AA319377 AW961532 T48452 AA894424
423476 22861 1 AL035633 F11794 F11783 H18042 T66089 H29379 R19493 AW134660 AI299437 AL133995 AA057405 N78357 AA917450 AI002692 T09262 T65008
H29290 AI200874 AA894415 AI732887 AI791768 AI733447 AA988785 N62128 T09261 AW956936
424572 24097.1 M19650 R18810 R18721 AW896146 AW889520 AA192362 AA176814 F12085 BE255264 BE251393 T65248 AA380585 AA380465 BE408684
AA459037 AW498869 AA776107 BE274289 D45269 M61958 AA378818 AW663180 AW672958 H08611 M78164 BE393721 AA348660 R36303
AW498662 AA019090 AA001087 AA054302 AA019775 AA018808 AA019132 AI858240 R73218 H30477 H17776 AA659570 BE276750 AL118657
AA375861 AA352427 AW581695 AI141188 N63474 AA654162 H17659 AL120696 T28867 AW498868 AI355918 AA902349 AA569098 AI088231
AI042604 AA555133 AI183611 AI608822 AI275941 AW316805 AA349486 AI355233 R85117 AW613626 R49234 AA458846 N20669 H18693 AA977567
T15423 AW002084 AI824721 N36242 AI417281 AI018212 AA912337 F09722 AA749449 AW879172 AA885427 AA916639 AI872560 F00482 H45184
AI217251 AA775807 BE390071 AA303517 AA001050 BE515169 N44066 AL133684 AI807085 AA808009 AA915914 F00007 AA019749 AL121560
AW675544 AW090233 AW072071 AI810932 AI089733 AW026222 AA770155 AI089547 AI085733 AW516061 AL037636 AL037635 AI863947 H50420
R11203 AA019133 N94772 N71842 N29047 AA778138 AA554336 AA179865 N59453 T65212 AA054270 AW806630 AA533375 D13146 AA349487
AU077160 BE255671 BE276795 BE250823 AL120301 BE311390 BE252483
424945 245223.1 AI221919 Z19967 AA348780 AW964077 AW166028 BE540193 N94800 AA452368 N99604 AI341345 AW298800 AA724961 AA931158 AI741227
AI806660 AI982626 D81263 D53937 D52496 AA974487 AW043854 N50483 Z39997 AI492961 AI361526 F04002 AA452141 T23551 AI472655
AI193667 AI341984 N92658 T32870 R52664 N50428 AW089291 AI934175 AI423737 D60665
424947 245247.1 R77952 AA348809 AW959960 AW959962 AI565552 AW070702 AA973910 R85973
425331 2501991 AW962128 AA355353 AA427363
426413 2666501 AA377823 AW954494 AI022688
426503 2682831 AA380153 AA380233 AW963529
426919 2735071 AL041228 D82004 D61361 AI203314 AI990307 AW900295 AI018308 AW087473 AW183530 AA393346 H50055 AA935601
428342 290035.2 AI739168 AA426249 AI199636 AW505198 AW977291 AA824583 AA883419 AA724079 AI015524 AI377728 AW293682 AI928140 AA731438 AI092404
AI085630AA731340
429007 298301.1 D80642 AA443145 AL119015 AW904500
429163 3005431 AA884766 AW974271 AA592975 AA447312
429421 30431 1 AL031658 AI693758 AL040619 AW977914 AA811957 AI352198 AW104364 AA648367 AA897604 AW341668 AI201382 AL040620
430183 314122 BE010038 AA676833 AI311783 T86895 W68032 BE064393 BE064394 BE157228 BE183282 AI936370 AA552514 T67280 AA039909
430676 32168.1 AF084866 AF084870 AF084864 AF084867 AF084869 AF084865 AF084868 AW818206 AW812038 BE144813 BE144812 AW812041 AW812040
AW812067 BE061583 BE061604 T05808 AI352469 AA580921 BE141783 BE141782 BE061601 AW814393 AW885029
430968 326269.1 AW972830 AA527647 AA489820 AA570362
433009 357371 1 AA761668 AA573621 R92814 R09670
433434 3660951 AA588429 AI972567 AW504832 AI299694
433523 3688731 H29882 AW665533 AW149901 AI572917 AA598500 AI686466 AI336390 AW864390 AW864320
435542 4077441 AA687376 H74234 AW975503
437034 4317131 AA742643 AA808575 AW976668
437056 4322621 AI147061 AA743380 AA765223 AW976398 AI803927
438458 4578371 AW975186 AA807807 D29548
439285 47065.1 AL133916 N79113 AF086101 N76721 AW950828 AA364013 AW955684 AI346341 AI867454 N54784 AI655270 AI421279 AW014882 AA775552
N62351 N59253 AA626243 AI341407 BE175639 AA456968 AI358918 AA457077
439518 473341 W76326AF086341 W72300
439566 473871 AF086387W77884 W72711
441102 5096041 AA973905 AI299888 AA917019 H63235 T90771
446692 6896231 Z44514 AI352097 AI803984 AW235923 AW196558 AI954637 AI336983
447197 7116231 R36075 AI366546 R36167
448044 7471961 AI458682 H24240 R14537 R18426 AW867082
449625 8113.1 NM.014253 AF100772BE088769 AL0227188E161779 AW863569 BE161640 AL039060 BE168542 AW296554 AA323193 AA235370 AW779760
N48674 AI375997 R45432 D59344 AI203107 F07491 R35360 R25094 AI913631 AI498402 T61382 AI016320 N45526 T61415 AA331486
450375 83327.1 AA009647 AA131254 AA374293 AW954405 H04410 AW606284 AA151166 BE157467 BE157601 H04384 W46291 AW663674 H04021 H01532
AA190993 H03231 H59605 H01642AA852876 AA113758 AA626915AA746952 AI161014 AA099554 R69067
450582 839331 AI339732 AA010300 AW515041 AA768334 N29860 AA425874 AA425118 AA865829 AW936878
451320 86576.1 AW118072 AI631982 T15734 AA224195 AI701458 W20198 F26326 AA890570 N90552 AW071907 AI671352 AI375892 T03517 R88265 AI124088
AA224388 AI084316 AI354686 T33652 AI140719 AI720211 T03490 AI372637 T15415 AW205836 AA630384 T03515 T33230 AA017131 AA443303
T33623 AI222556 T33511 T33785 AI419606055612
453331 96214.1 AI240665 T53681 N77468 H51833 AA147247 R75732 C18450 R73999 AI095755 T49904 H03868 AA411580 R33395 AA410586 T48869 D63292
R31981 H12498 H02668 AA035018 R75957 AI803329 R27528 R36203 AI809932 AI808765 R78948 AA411449 AA976929 AI378760 AI378620 T48870
R73906 R75632 H03612 AA909684 N50695 H02580 H12839 N58781 AA742532 AI360919 H03502 BE208298 R68588 AI350463 R31935 AW069127
AA411621 R25671 R36105 H12451 H03869 H51263 AA035486 R25109 R25110 AA147933
453739 979419.1 AL120266 AW269469 AW890114 454171 1049240.1 AW854832 AW854798 AW854857 AW854816 AW854834 AW854817 455646 1348557.1 BE064420 BE064435 BE064429 BE064414 BE064400 BE064517 458912 823104.1 AI911066 AI933734 AI680888 AJ003599
TABLE 15C Pkey Unique number corresponding to an Eos probeset Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham, et al * refers to the publication endded "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted
Nt_posιdor i Indicates nucleotide positions of predicted exons
Pkey Ref Strand Nt position
400533 6981826 Minus 277132-277595
400777 8131663 Plus 70745-71121
401272 9797373 Minus 98374-98509
402145 8018280 Plus 113086-114800
402604 9909420 Plus 20393-20767
402605 9909420 Minus 47680-47973
402855 9662953 Minus 59763-59909
403142 9444521 Plus 89286-90131
403341 8569175 Plus 30699-30910
403696 3135242 Minus 143467-143634
403790 8084957 Minus 87826-87947,89835-90002
404150 7534008 Plus 165811-165943
404283 2276311 Minus 99460-99564
404541 8318559 Plus 103456-103664
404584 9857511 Plus 138651-139153
404632 9796668 Plus 45096-45229
404819 4678240 Plus 16223-16319,16427-16513,16736-16859,16941-17075,17170-17287,17389-17529,18261-18357,18443-18578
405238 7249119 Minus 51728-51836
405239 7249119 Plus 144345-144464,144690-144836,151750-151883,152407-152484
405348 2914717 Minus 43310-43462
405605 5836195 Minus 117070-117270
405819 4007557 Plus 2830-2967
TABLE 16A ABOUT 859 GENES UP-REGULATED IN GLIOBLASTOMA MULTIFORMA COMPARED TO NORMAL CENTRAL NERVOUS SYSTEM Table 16A lists about 859 genes up-regulated in glioblastoma muldforma (GBM) compared to normal central nervous system (CNS) These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the ratio of 'average* LGG to "average" CNS tissues was greater than or equal to 30 The "average* GBM level was set to the 85* percentile amongst vaπous GBM tumors The "average* normal CNS dssue level was set to the 85* percendle amongst vnous CNS dssues In order to remove gene-specific background levels of non-specific hybπdizadon, the 10* percendle value amongst vaπous non-malignant dssues was subtracted from both the numerator and the denominator before the rado was evaluated
Pkey Unique Eos probese it idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene title
R1 Rado of GLIOBLASTOMA MULTIFORMA to CNS
Pkey ExAccn UnigenelD Unigene Title R1
414555 N98569 Hs 76422 phospholipase A2, group HA (platelets, 47 2
422737 M26939 Hs 119571 collagen, type III, alpha 1 (Ehlers-Danl 449
423961 013666 Hs 136348 penosdn (OSF-2os) 333
433001 AF217513 Hs 279905 clone HQ0310 PRO0310p1 259
449539 W80363 Hs 58446 ESTs 258
417308 H60720 Hs 81892 KIAA0101 gene product 233
424800 AL035588 Hs 153203 MyoD family inhibitor 230
414825 X06370 Hs 77432 epidermal growth factor receptor (avian 196
431941 AK000106 Hs 272227 Homo sapiens cDNA FU20099 fis, clone CO 187
453392 U23752 Hs 32964 SRY (sex determining region Y)-box 11 17 8
444190 AI878918 Hs 10526 cysteine and glycine-πch protein 2 178
428330 L22524 Hs 2256 matπx metalloproteinase 7 (matπlysin 177
417130 AW276858 Hs 81256 S100 calcium-binding protein A4 (calcium 17 5
414217 AI309298 Hs 279898 Homo sapiens cDNA FU23165 fis, clone L 170
428242 H55709 Hs 2250 leukemia inhibitory factor (cholmergic 159
425397 J04088 Hs 156346 topoisomerase (DNA) II alpha (170kD) 156
424635 AA420687 Hs 115455 Homo sapiens cDNA FU 14259 fis, clone PL 152
408243 Y00787 Hs 624 interieukin 8 147
422672 X12784 Hs 119129 collagen, type IV, alpha 1 147
434078 AW880709 Hs 283683 chromosome 8 open reading frame 4 146
409799 D11928 Hs 76845 phosphoseπne phosphatase-like 142
414761 AU077228 Hs 77256 enhancer of zeste (Drosophila) homolog 2 14 2
442432 BE093589 Hs 38178 hypothedcal protein FU23468 14 1
446584 U53445 Hs 15432 downregulated in ovaπan cancer 1 14 0
444969 AI203334 Hs 160628 ESTs 135
430691 C1 187 Hs 103538 ESTs 129
426075 AW513691 Hs 270149 ESTs, Weakly similar to 2109260A B cell 124
445101 T75202 Hs 12314 Homo sapiens mRNA, cDNA DKFZp586C1019 (f 12 1
441269 AW015206 Hs 178784 ESTs 11 9
417426 NM_0O2291 Hs 82124 laminin, beta 1 11 9
430132 AA204686 Hs 234149 hypothedcal protein FU20647 11 8
422163 AF027208 Hs 112360 promimn (mouse)-lιke 1 11 3
411411 AA345241 Hs 55950 ESTs, Weakly similar to KIAA1330 protein 11 3
449722 BE280074 Hs 23960 cyclin B1 11 2
436291 BE568452 Hs 344037 protein regulator of cytokinesis 1 11 0
435020 AW505076 Hs 301855 DiGeorge syndrome cndcal region gene 8 109
412140 AA219691 Hs 73625 RAB6 interacting, kines -like (rabkines 109
419239 AA468183 Hs 184598 Homo sapiens cDNA FLJ23241 fis, clone C 106
417043 NM 004369 Hs 80988 collagen, type VI, alpha 3 106
413929 BE501689 Hs 75617 collagen, type IV, alpha 2 106 420602 AF060877 Hs 99236 regulator of G-protem signalling 20 106
409142 AL136877 Hs 50758 SMC4 (structural maintenance of chromoso 104
406972 M32053 gb Human H19 RNA gene, complete eds 104
412986 X81120 Hs 75110 cannabinoid receptor 1 (brain) 103
419508 AW997938 Hs 90786 ATP-bmding cassette, sub-family C (CFTR 103
449611 AI970394 Hs 197075 ESTs 101
427581 NM 014788 Hs 179703 KIAA0129 gene product 10 1
431512 BE270734 Hs 2795 lactate dehydrogenase A 99
429183 AB014604 Hs 197955 KIAA0704 protein 98
433437 U20536 Hs 3280 caspase 6 apoptosis-related cysteine pr 97
424840 D79987 Hs 153479 extra spindle poles, S cerevisiae, homo 97
433800 AI034361 Hs 135150 lung type-l cell membrane associated gly 97
433647 AA603367 Hs 222294 ESTs 97
414622 AI752666 Hs 76669 mcodnamide N-methyltransferase 95
413719 BE439580 Hs 75498 small inducible cytokine subfamily A (Cy 93
409461 AA382169 Hs 54483 N-myc (and STAT) interactor 93
409902 AI337658 Hs 156351 ESTs 93
450375 AA009647 a dismtegnn and metalloproteinase doma 92
445873 AA250970 Hs 251946 poly(A)-bιndιng protein, cytoplasmic 1-1 9 1
442802 AL133035 Hs8728 hypothedcal protein DKFZp434G171 9 1
452461 N78223 Hs 108106 transcnpdon factor 9 1
434846 AW295389 Hs 119768 ESTs 9 1
422158 L10343 Hs 112341 protease inhibitor 3, skin-deπved (SKAL 90
425187 AW014486 Hs 22509 ESTs 90
443247 BE614387 Hs 333893 c-Myc target JP01 87
458079 AI796870 Hs 54277 DNA segment on chromosome X (unique) 992 87
410276 AI554545 Hs 68301 angιopoιedπ-2 86
402855 NM.001839* Homo sapiens calpon 3, acid 86
439710 AF086543 gb Homo sapiens full length insert cDNA 86
411968 AI207410 Hs 69280 Homo sapiens, clone IMAGE 3636299 mRNA, 86
410102 AW248508 Hs 279727 ESTs, homologue of PEM-3 [Dona savignyi 86
436895 AF037335 Hs 5338 carbonic anhydrase XII 86
418203 X54942 Hs 83758 CDC28 protein kinase 2 86
416892 L24498 Hs 80409 growth aπest and DNA-damage-iπducible, 85
425234 AW152225 Hs 165909 ESTs, Weakly similar to 138022 hypothed 85
449961 AW265634 Hs 133100 ESTs 85
449444 AW818436 Hs 23590 solute earner family 16 (monocarboxylic 84
417061 AI675944 Hs 188691 Homo sapiens cDNA FLJ12033 fis, clone HE 83
453884 AA355925 Hs 36232 KIAA0186 gene product 83
424085 NM.002914 Hs 139226 replicadon factor C (acdvator 1) 2 (40 82
419938 AU076772 Hs 1279 complement component 1, r subcomponent 8 1
411078 AI222020 Hs 182364 CocoaCnsp 8 1
406850 AI624300 Hs 172928 collagen, type I, alpha 1 80
447726 AL137638 Hs 19368 matnlin 2 80
439999 AA115811 Hs 6838 ras homolog gene family, member E 80
416658 U03272 Hs 79432 fibπllin 2 (congenital coπtractural ara 79
439451 AF086270 Hs 278554 heterochromadn-like protein 1 79
458814 AI498957 Hs 170861 ESTs, Weakly similar to Z195 HUMAN ZINC 79
447004 AW296968 Hs 157539 ESTs 79
436140 W87355 Hs 269587 ESTs 79
436607 AW661783 Hs 211061 ESTs 78
422809 AK001379 Hs 121028 hypothedcal protein FU10549 77
440052 AI633744 Hs 195648 ESTs, Weakly similar to I38022 hypothed 77
422106 D84239 Hs 111732 Fc fragment of IgG binding protein 77
418113 AI272141 Hs 83484 SRY (sex determining region Y)-box 4 77
410286 AI739159 Hs 61898 DKFZP586N2124 protein 77
424687 J05070 Hs 151738 matπx metalloproteinase 9 (geladnase B 76
422048 NM.012445 Hs 288126 spondin 2, extracellular matπx protein 76
421988 AW450481 Hs 161333 ESTs 76
452620 AA436504 Hs 119286 ESTs 76
453941 U39817 Hs 36820 Bloom syndrome 75
416737 AF154335 Hs 79691 LIM domain protein 75
425289 AW139342 Hs 155530 interferon, gamma-mducible protein 16 75
418400 BE243026 Hs 301989 KIAA0246 protein 75
437036 AI571514 Hs 133022 ESTs 75
421899 AJ011895 Hs 109281 Nef-associated factor 1 74
409731 AA125985 Hs 56145 thymos , beta identified in neuroblast 74
427528 AU077143 Hs 179565 minichromosome maintenance deficient (S 74
427871 AW992405 Hs 59622 Homo sapiens, clone IMAGE 3507281, mRNA, 73
448935 AL078596 Hs 22591 nuclear receptor subfamily 2, group E, 73
415079 R43179 Hs 22895 hypothedcal protein FLJ23548 73
449571 AW016812 Hs 200266 ESTs 73
427899 AA829286 Hs 332053 serum amyloid A1 73
447458 AI741082 Hs 158961 ESTs 73
430630 AW269920 Hs 2621 cystat A (stefin A) 72
411252 AB018549 Hs 69328 MD-2 protein 72
432731 R31178 Hs 287820 fibronecdn 1 72
454117 BE410100 Hs 40368 adaptor-related protein complex 1, sigma 72
407881 AW072003 Hs 40968 heparan sulfate (glucosamme) 3-O-sulfot 72
428728 NM.016625 Hs 191381 hypothetical protein 7 1
416111 AA033813 Hs 79018 chromatin assembly factor 1 , subunit A ( 7 1
432281 AK001239 Hs 274263 hypothetical protein FLJ10377 7 1
410434 AF051152 Hs 63668 toll like receptor 2 7 1 420018 U56387 Hs 94376 proprotein convertase subdlisin/kexin t 7 1
418293 AI224483 Hs 16063 hypothetical protein FLJ21877 71
424954 NM 000546 Hs 1846 tumor protein p53 (Li-Fraumeni syndrome) 70
445900 AF070526 Hs 125036 Homo sapiens clone 24787 mRNA sequence 70
419741 NM 007019 Hs 93002 ubiquitin earner protein E2-C 70
422283 AW411307 Hs 114311 COC45 (cell division cycle 45, S cerevis 70
434808 AF155108 Hs 256150 Homo sapiens Similar to RIKEN cDNA 2810 69
416847 L43821 Hs 80261 enhancer of filamentatioπ 1 (cas-like o 69
424381 AA285249 Hs 146329 protein kinase Chk2 69
410064 X53416 Hs 195464 filamin A, alpha (acdn-bmdmg protem- 69
415682 AI347128 Hs 191870 ESTs 69
421977 W94197 Hs 110165 πbosomal protein L26 hoπrølog 68
429447 AW812452 Hs 83286 ESTs, Weakly similar to S14747 sphingomy 68
423198 M81933 Hs 1634 cell division cycle 25A 68
413627 BE182082 Hs 246973 ESTs 68
412777 AI335773 Hs 270123 ESTs 68
409829 M33552 Hs 56729 lymphocyte-specific protein 1 68
451129 BE072881 gb RC2-BT0548-200300-012-e09 BT0548 Homo 68
444381 BE387335 Hs 283713 ESTs, Weakly similar to S64054 hypothed 67
446131 NM 000929 Hs 290 phospholipase A2, group V 67
441703 AW390054 Hs 192843 leucine zipper protein FKSG14 67
420311 AW445044 Hs 38207 Human DNA sequence from clone RP4-530I15 67
425202 AW962282 Hs 152049 ESTs, Weakly similar to I38022 hypothed 67
408161 AW952912 Hs 300383 hypothetical protein MGC3032 67
440704 M69241 Hs 162 insulin-like growth factor binding prote 67
407182 AA312551 Hs 230157 ESTs 67
445837 AI261700 Hs 145544 ESTs 66
433376 AI249361 Hs 74122 caspase 4, apoptosis-related cysteine pr 66
431211 M86849 Hs 323733 gapiuπcdon protein, beta 2, 26kD (conn 66
447439 AA313565 Hs 145020 ESTs, Weakly similar to KIAA1205 protein 65
407235 D20569 Hs 169407 SAC2 (suppressor of acdn mutadons 2, y 65
450506 NM 004460 fibroblast acdvadon protein, alpha 65
432593 AW301003 Hs 51483 ESTs Weakly similar to hypothedcal pro 65
418054 NM.002318 Hs 83354 lysyl oxidase-like 2 65
452799 AI948829 Hs 213786 ESTs 65
446657 AI335191 Hs 260702 ESTs, Weakly similar to 2109260A B cell 64
424247 X14008 Hs 234734 lysozyme (renal amyloidosis) 64
443884 N20617 Hs 194397 lepdn receptor 64
420560 AW207748 Hs 59115 ESTs 64
419485 AA489023 Hs 99807 ESTs. Weakly similar to unnamed protein 63
420649 AI866964 Hs 124704 ESTs, Moderately similar to S65657 alpha 63
457465 AW301344 Hs 122908 DNA replicadon fxtor 63
440332 AI218517 Hs 188051 ESTs 63
449246 AW411209 Hs 23363 hypothedcal protein FU10983 63
413063 AL035737 Hs 75184 chidnase 3-lιke 1 (cartilage glycoprote 62
448275 BE514434 Hs 20830 kmesin-like 2 62
440286 U29589 Hs 7138 cholinergic receptor, muscaπnic 3 62
439518 W76326 gb zd60d04 r1 Soares.fetal_heart_NbHH19W 6 1
412567 AI750979 Hs 74034 Homo sapiens clone 24651 mRNA sequence 6 1
426935 NM 000088 Hs 172928 collagen, type I, alpha 1 6 1
456977 AK000252 Hs 169758 hypothedcal protein FLJ20245 6 1
428450 NM 014791 Hs 184339 KIAA0175 gene product 60
412125 Y17114 Hs 73393 eyes absent (Drosophila) homolog 4 60
413786 AW613780 Hs 13500 ESTs 60
410555 U92649 Hs 64311 a dismtegnn and metalloproteinase doma 59
400419 AF084545 Target 59
408380 AF123050 Hs 44532 diubiquidn 59
426108 AA622037 Hs 166468 programmed cell death 5 59
414774 X02419 Hs 77274 plasmmogen acdvator urokinase 59
437695 AA769202 Hs 192142 ESTs 58
409463 AI458165 Hs 17296 hypothetical protein MGC2376 58
411048 AK001742 Hs 67991 hypothetical protein DKFZp434G0522 58
443731 AI083928 Hs 145418 ESTs 58
405558 Target Exon 58
422094 AF129535 Hs 272027 F-box only protein 5 58
429113 D28235 Hs 196384 proslagtandin-endoperox.de synthase 2 (p 58
425882 U83115 Hs 161002 absent in melanoma 1 58
412471 M63193 Hs 73946 endothelial cell growth factor 1 (platel 58
429149 AW193360 Hs 197962 ESTs, Weakly similar to I38022 hypothed 58
436827 H72187 Hs 5322 guanine nucleotide binding protein (G pr 57
425905 AB032959 Hs 318584 novel C3HC4 type Zinc finger (πng finge 57
414053 BE391635 Hs 75725 transgelin 2 57
436805 AA731533 Hs 270751 ESTs 57
442201 AW516704 Hs 208726 ESTs 57
453361 AA035197 Hs 107375 ESTs 56
429083 Y09397 Hs 227817 BCL2-related protein A1 56
426490 NM 001621 Hs 170087 aryl hydrocarbon receptor 56
423081 AF262992 Hs 123159 sperm associated antigen 4 56
407013 U35637 gb Human nebulin mRNA, partial eds 55
406478 Target Exon 55
435937 AA830893 Hs 119769 ESTs 55
453362 H1 988 Hs 107375 ESTs 55
449969 AW295142 Hs 180187 Homo sapiens cDNA FU14337 fis, clone PL 55 442547 AA306997 Hs 217484 ESTs, Weakly similar to ALU1.HUMAN ALU S 55
443883 AA114212 Hs 9930 serine (or cysteine) proteinase iπhibito 55
429643 AA455889 Hs 167279 FYVE-finger-contain g Rab5 effector pro 55
407862 BE548267 Hs 337986 Homo sapiens cDNA FU 10934 fis, clone OV 54
407624 AW157431 Hs 248941 ESTs 54
448769 N66037 Hs 38173 ESTs 54
417124 BE122762 Hs 25338 ESTs 54
422493 AW474183 Hs 250173 hypothedcal protein FU13158 54
457292 AI921270 Hs 281462 hypothetical protein FLJ 14251 53
418596 AW976721 Hs 293327 ESTs 53
410295 AA741357 Hs 5174 mdogen (enacdn) 53
433323 AA805132 Hs 159142 ESTs 53
412326 R07566 Hs 73817 small inducible cytokine A3 (homologous 53
418630 AI351311 Hs 251946 poly(A)-bιndιng protein, cytoplasmic 1-1 53
420075 AF142482 Hs 203846 TEA domain family member 3 52
427676 AA394062 Hs 300772 tropomyosin 2 (beta) 52
407729 T40707 Hs 270862 ESTs 52
416908 AA333990 Hs 80424 coagulation factor XIII, A1 polypepdde 52
414372 AA143654 gb zo65a02 r1 Stratagene pancreas (93720 52
433556 W56321 Hs 111460 calcium calmodulin-dependent protein k 52
424998 U58515 Hs 154138 chidnase 3-lιke 2 52
407603 AW955705 Hs 62604 Homo sapiens, clone IMAGE 4299322, mRNA, 52
445118 AI208762 Hs 345572 ESTs 52
408523 AW833259 Hs 314287 ESTs 52
412530 AA766268 Hs 266273 hypothedcal protein FU 13346 52
449300 AI656959 Hs 346514 ESTs 52
429732 U20158 Hs 2488 lymphocyte cytosolic protein 2 (SH2 doma 52
423757 AL049337 Hs 132571 Homo sapiens mRNA, cDNA DKFZp564P016 (fr 5 1
439570 T79925 Hs 269165 ESTs, Weakly similar to ALU1_HUMAN ALU S 51
415323 BE269352 Hs 949 neutrophil cytosolic factor 2 (65kD, chr 5 1
443604 C03577 Hs 9615 myosin regulatory light chain 2 smooth 5 1
421247 BE391727 Hs 102910 general transcnpdon factor II H, polype 51
416913 AW934714 gb RC1-DT0001-031299-011-a11 DT0001 Homo 5 1
419968 X04430 Hs 93913 interieukin 6 (interferon, beta 2) 50
424009 F11690 gb HSC30D041 normalized infant brain cDN 50
418283 S79895 Hs 83942 cathepsin K (pycnodysostosis) 50
429469 M64590 Hs 27 glycine dehydrogenase (decarboxyladng, 50
417404 NM 007350 Hs 82101 pleckstnn homology-like domain, family 50
408829 NM 006042 Hs 48384 heparan sulfate (glucosamine) 3-O-sulfot 50
418097 R45137 Hs 21868 ESTs 50
453331 AI240665 ESTs 49
429433 AA452899 Hs 213586 ESTs Weakly similar to KIAA1353 protein 49
426044 AA502490 Hs 170290 ESTs 49
444161 N52543 Hs 142940 ESTs 49
428227 AA321649 Hs 2248 small inducible cytokine subfamily B (Cy 49
432242 AW022715 Hs 162160 ESTs Weakly similar to ALU4_HUMAN ALU S 49
447752 M73700 Hs 105938 lactotransferπn 49
439627 BE621702 Hs 29076 hypothetical protein FLJ21841 49
402274 C19000498* gι|4567179|gb|AAD23607 1|AC00 49
444656 AI277924 Hs 145199 ESTs 49
422087 X58968 Hs 111301 matrix metalloproteinase 2 (geladnase A 49
443744 AI084326 Hs 271548 ESTs, Weakly similar to I78885 senne/th 49
416871 H98716 gb yx13d08 s1 Soares melanocyte 2NbHM Ho 49
409112 BE243971 Hs 50649 quinone oxidoreductase homolog 48
403481 Target Exon 48
443740 R56434 Hs 21062 ESTs 48
435005 U80743 Hs 306094 tπnucleodde repeat containing 12 48
429163 AA884766 gb am20a10 s1 Soares_NFL_T_GBC_S1 Homo s 48
451418 BE387790 Hs 26369 hypothedcal protein FU20287 48
428403 AI393048 Hs 326159 leucine nch repeat (in FLU) interacdn 48
430968 AW972830 gb EST384925 MAGE resequences, MAGL Homo 48
425212 AW962253 Hs 171618 ESTs 48
409205 AI952884 Hs 14832 ESTs, Moderately similar to unnamed prot 48
431176 AI026984 Hs 293662 ESTs 48
420092 AA814043 Hs 88045 ESTs 48
437834 AA769294 Hs 283854 gb nz36g03 s1 NCI_CGAP_GCB1 Homo sapiens 48
432363 AA534489 gb nf76g11 s1 NCI_CGAP_Co3 Homo sapiens 48
403011 ENSP00000215330* Probable seπne/threoni 47
405348 C7001664 gι|12698061|db||BAB21849 1| (AB 47
447072 D61594 Hs 17279 tyrosylprotem sulfotransferase 1 47
443318 AI051603 Hs 133141 ESTs 47
421027 AA761198 Hs 55254 ESTs 47
449318 AW236021 Hs 78531 Homo sapiens, Similar to RIKEN cDNA 5730 47
429170 NM 001394 Hs 2359 dual specificity phosphatase 4 47
411852 AA528140 Hs 107515 ESTs Weakly similar to T00329 hypothed 47
450166 AA429504 ESTs 47
438456 AA913381 Hs 20594 ESTs 47
446839 BE091926 Hs 16244 mitodc spindle coiled-coil related prot 47
438527 AI969251 Hs 115325 RAB7, member RAS oncogene family-like 1 47
458946 AA009716 Hs 42311 ESTs 47
454860 AW835767 gb QV4-LT0016-240200-110-M.8 LT0016 Homo 47
424736 AF230877 Hs 152701 microtubule-interactmg protein that ass 47
443426 AF098158 Hs 9329 chromosome 20 open reading frame 1 46 422648 D86983 Hs 118893 Melanoma associated gene 46
431319 AA873350 Hs 302232 ESTs 46
445666 R59960 Hs 282386 ESTs 46
416406 D86961 Hs 79299 lipoma HMGIC fusion partner-like 2 46
422887 AI751848 Hs 49215 ESTs 46
422938 NM 001809 Hs 1594 centromere protein A (17kD) 46
405141 Y14443 zinc finger protein 200 46
440210 AW674562 Hs 125296 ESTs 46
432527 AW975028 Hs 102754 ESTs 46
439726 AW449893 Hs 293707 ESTs, Weakly similar to I38598 zinc fiπg 46
435143 R12375 Hs 194600 ESTs 46
422170 AI791949 Hs 112432 and-Mullenan hormone 46
452874 AK001061 Hs 30925 hypothedcal protein FU10199 46
408996 AI979168 Hs 344096 glycoprotein (transmembrane) nmb 46
412568 AI878826 Hs 74034 caveolin 1, caveolae protein, 22kD 45
426215 AW963419 Hs 155223 stanniocalcin 2 45
413076 U10564 Hs 75188 weel (S pombe) homolog 45
456759 BE259150 Hs 127792 delta (Drosophιla)-lιke 3 45
419735 AW750056 Hs 169577 Homo sapiens cDNA FU14743 fis, clone NT 45
433675 AW977653 Hs 75319 πboπucleodde reductase M2 polypeptide 45
441217 AI922183 Hs 213246 ESTs 45
435542 AA687376 ESTs 45
440435 AL042201 Hs 21273 transcnpdon factor NYD-sp10 45
400288 X06256 Hs 149609 integnn, alpha 5 (fibronecdπ receptor, 45
416114 AI695549 Hs 183868 glucuromdase, beta 45
437323 AA371145 Hs 194397 lepdn receptor 45
425139 AW630488 Hs 25338 protease, senne, 23 45
423678 AW963357 Hs 7847 ESTs 45
403961 Target Exon 45
443462 AI064690 Hs 171176 ESTs 45
418483 W26076 Hs 221847 ESTs 45
428873 AI701609 Hs 98908 ESTs 45
410268 AA316181 Hs 61635 six transmembrane epithelial antigen of 45
408298 AI745325 Hs 271923 Homo sapiens cDNA FU22785 fis, clone K 45
449145 AI632122 Hs 198408 ESTs 44
439574 AI469788 Hs 165190 ESTs 44
423905 AW579960 Hs 135150 lung type-l cell membrane associated gly 44
453387 AI990741 Hs 252809 ESTs 44
447444 AK000318 Hs 18616 hypothedcal protein FU20311 44
433507 AI817336 Hs 191791 ESTs 44
448048 BE281291 Hs 170408 ESTs, Moderately similar to A47582 B-cel 44
421064 AI245432 Hs 101382 tumor necrosis factor, alpha-induced pro 44
402604 Target Exon 44
446291 BE397753 Hs 14623 interferon, gamma-inducible protein 30 44
424503 NM.0O2205 Hs 1 9609 integnn, alpha 5 (fibronecdn receptor, 44
423600 AI633559 Hs 310359 ESTs 44
403361 NM.002210" Homo sapiens integnn, alpha 44
408432 AW195262 gb xn67b05 x1 NCI.CGAP.CML1 Homo sapiens 44
424489 T48851 Hs 274470 D-siglec precursor, 43
442264 AI278777 Hs 263455 ESTs, Weakly similar to ALU1.HUMAN ALU S 43
447247 AW369351 Hs 287955 Homo sapiens cDNA FU 13090 fis, clone NT 43
417018 M16038 Hs 80887 v-yes-1 Yamaguchi sarcoma viral related 43
414020 NM 002984 Hε 75703 small inducible cytokine A4 (homologous 43
439566 AF086387 gb Homo sapiens full length insert cDNA 43
425242 D13635 Hs 155287 KIAA0010 gene product 43
423529 T87318 Hs 120411 ESTs 43
439538 AA837323 Hs 56407 ESTs 43
453682 T79703 gb yd71e08 r1 Soares fetal liver spleen 43
425259 AL049280 Hs 155397 Homo sapiens mRNA, cDNA DKFZp564K143 (fr 43
417918 AA209205 Hs 163754 hypothedcal protein FU 12606 43
426649 AI914936 Hs 97152 ESTs 43
438875 AA827640 Hs 189059 ESTs 43
445868 BE169357 Hs 207428 ESTs 43
426509 M31166 Hs 2050 pentaxin-related gene, rapidly induced b 43
409893 AW247090 Hs 57101 minichromosome maintenance deficient (S 43
432058 AW665996 Hs 130729 ESTs, Weakly similar to ALU1 HUMAN ALU S 43
430694 AA810624 Hs 30936 ESTs, Weakly similar to H2BH.HUMAN HISTO 43
441523 AW514263 Hs 301771 ESTs, Weakly similar to ALUF.HUMAN »» 42
443950 NMJJ01425 Hs 9999 epithelial membrane protein 3 42
419896 Z99362 gb HSZ99362 DKFZphamyl Homo sapiens cDNA 42
452994 AW962597 Hs 31305 KIAA1547 protein 42
420841 AI625251 Hs 94037 hypothedcal protein FU23053 42
441255 R06350 Hs 171635 ESTs 42
416426 AA180256 Hs 210473 Homo sapiens cDNA FLJ 14872 fis, clone PL 42
411789 AF245505 Hs 72157 Adlican 42
409638 AW450420 Hs 21335 ESTs 42
439192 AW970536 Hs 105413 ESTs 42
440684 AI253123 Hs 127356 ESTs, Highly similar to S21424 nesdn (H 42
437470 AL390147 Hs 134742 hypothedcal protein DKFZp547D065 42
432343 NM_002960 HS 2961 SlOOcalcium-binding protein A3 42
401454 NM_014226* Homo sapiens renal tumor and 42
431770 BE221880 Hs 268555 5'-3' exoπbonuclease 2 42
442326 H92962 Hs 124813 hypothedcal protein MGC14817 42 419402 Z68155 Hs 90291 laminin, beta 2 (laminin S) 4 2
435703 AW630133 Hs 83313 GK003 protein 4 2
444609 AW571659 Hs 278081 ESTs 4 2
404407 Target Exon 42
450581 AF081513 Hs 25195 TGF-beta 4 42
407838 BE146411 Hs 40342 putadve nuclear protein 4 1
410407 X66839 Hs 63287 carbonic anhydrase IX 4 1
418883 BE387036 Hs 1211 acid phosphatase 5, tartrate resistant 4 1
438898 AI819863 Hs 106243 ESTs 4 1
421674 T10707 Hs 296355 hypothetical protein FU23138 4 1
445921 AW015211 Hs 146181 ESTs 4 1
453055 AW291436 Hs 31917 Homo sapiens, done MGC 9658 mRNA comp 4 1
413450 Z99716 Hs 75372 N-acetylgalactosaminidase, alpha- 4 1
427463 AA442224 Hs 97900 ESTs 4 1
450639 AI703186 Hs 277174 ESTs 4 1
417576 AA339449 Hs 82285 phosphoπbosylglycinamide formyltransfer 4 1
437269 AA334384 Hs 149420 ESTs 4 1
415688 AA166963 gb zo86d01 s1 Stratagene ovanan cancer 4 1
414300 AI304870 Hs 188680 ESTs 4 1
413278 BE563085 Hs 833 interferon-sdmulated protein, 15 kDa 4 1
415024 AI983981 Hs 189114 ESTs 4 1
408102 U46351 Hs 621 lectin, galactoside-binding, soluble, 3 4 1
448019 AW947164 Hs 195641 ESTs, Moderately similar to I38022 hypot 4 1
451433 AA021140 Hs 269265 ESTs, Weakly similar to A46010 X-lmked 4 1
446523 NM 003063 Hs 334629 sarcolipin 4 1
427700 AA262294 Hs 180383 dual specificity phosphatase 6 4 1
402239 Target Exon 41
423713 AW754182 gb RC2-CT0321-131199-011-c01 CT0321 Homo 4 1
437814 AI088192 Hs 135474 ESTs, Weakly similar to DDX9JHUMAN ATP-D 4 1
414948 C15240 Hs 182155 ESTs 40
421307 BE539976 Hs 103305 Homo sapiens mRNA, cDNA DKFZp434B0425 (f 40
427375 AL035460 Hs 177536 metallocarboxypepddase CPX-1 40
450297 AW901347 Hs 38592 hypothedcal protein FU23342 40
449655 AI021987 Hs 59970 ESTs 40
439978 BE139460 Hs 124673 Homo sapiens cDNA FU 11477 fis, clone HE 40
432842 AW674093 Hs 334822 hypothetical protein MGC4485 40
422282 AF019225 Hs 114309 apolipoprotein L 40
452574 AF127481 Hs 301946 lymphoid blast cnsis oncogene 40
449256 AA059050 Hs 59847 ESTs 40
453385 AW296101 Hs 252806 ESTs 40
443715 AI583187 Hs 9700 cyclin E1 40
451778 AI826131 Hs 62954 ESTs, Weakly similar to zinc finger prot 40
441287 AW293132 Hs 131373 ESTs 40
418661 NM 001949 Hs 1189 E2F transcnpdon factor 3 40
420894 AA744597 Hs 88854 ESTs 40
454120 AB032990 Hs 40719 hypothetical protein KIAA1164 40
441627 AA947552 Hs 58086 branched chain aminotransferase 1, cytos 40
453948 AI970797 Hs 64859 ESTs 40
444170 AW613879 Hs 102408 ESTs 40
427221 L15409 Hs 174007 von Hippel Undau syndrome 40
418821 AA436002 Hs 183161 ESTs 40
418216 AA662240 Hs 283099 AF15q14 protein 40
435106 AA100847 Hs 5978 ESTs Highly similar to AF174600 1 F-box 40
430890 X54232 Hs 2699 glypican 1 39
429490 AI971131 Hs 23889 ESTs, Weakly similar to ALU7.HUMAN ALU S 39
425292 NM 005824 Hs 155545 37 kDa leucine-nch repeat (LRR) protein 39
436265 AA731331 Hs 190668 ESTs 39
407304 AA565832 Hs 271649 gb n|32b03 s1 NCI_CGAP_AA1 Homo sapiens 39
433244 AB040943 Hs 271285 KIAA1510 protein 39
446960 AW294936 Hs 156762 ESTs 39
406627 T64904 Hs 163780 ESTs 39
420552 AK000492 Hs 98806 hypothedcal protein 39
402082 C18000743* gι|6678363|reqNP_033416 1| t 39
419594 AA013051 Hs 91417 topoisomerase (DNA) II binding protein 39
448966 AW37291 Hs 86149 phosphoinositol 3-phosphate-bιndιng prot 39
427527 AI809057 Hs 293441 immunoglobulin heavy constant mu 39
422564 AI148006 Hs 222120 ESTs 39
418781 T41160 Hs 8404 ESTs 39
431820 AW410408 Hs 271167 L-pipecodc acid oxidase 39
413095 AA494359 Hs 30715 potassium voltage-gated channel, Isk-rel 39
430637 BE160081 Hs 256290 SlOO calcium-bmding protein A11 (calgiz 39
443539 AI076182 Hs 134074 ESTs, Moderately similar to ALU6_HUMAN A 39
422173 BE385828 Hs 250619 phorbolin-like protein MDS019 39
433388 AI432672 Hs 288539 hypothedcal protein FU22191 38
403849 Target Exon 38
406646 M33600 Hs 308026 major histocompatibility complex, class 38
445075 AI651827 Hs 344767 ESTs 38
420004 AW975532 Hs 164039 ESTs, Moderately similar to I38022 hypot 38
449670 F07693 Hs 85603 Homo sapiens mRNA, cDNA DKFZp434K2172 (f 38
424479 AF064238 Hs 149098 smoothelin 38
449625 NM 014253 odz (odd Oz/ten-m, Drosophila) homolog 1 38
418641 BE243136 Hs 86947 a dismtegnn and metalloproteinase doma 3 8
439979 AW600291 Hs 6823 hypothedcal protein FU10430 38 427286 AW732802 Hs 2132 epidermal growth factor receptor pathway 38
453920 AI133148 Hs 36602 1 factor (complement) 38
453857 AL080235 Hs 35861 DKFZP586E1621 protein 38
406872 AI760903 gb wι09h08 x1 NCI_CGAP_CLL1 Homo sapiens 38
403696 C4001100* gι|5852342|gb|AAD54015 1| (AF0 38
417791 AW965339 Hs 111471 ESTs 38
418036 Z37976 Hs 83337 latent transforming growth factor beta b 38
404209 Target Exon 38
431454 AW975980 Hs 292918 ESTs 38
410422 AL042014 Hs 63348 Homo sapiens, clone MGC 15203, mRNA, com 38
406739 AI566709 Hs 182426 nbosomal protein S2 38
450810 BE207588 Hs 334360 transforming growth factor beta 1 induce 38
457876 AI821940 ESTs, Moderately similar to ALU8.HUMAN A 38
435718 R06569 Hs 269534 ESTs 38
429716 R25685 Hs 211933 collagen, type XIII, alpha 1 38
442710 AI015631 Hs 23210 ESTs 38
456534 X91195 Hs 100623 phospholipase C, beta 3, neighbor pseudo 38
419764 BE262524 Hs 93183 vasodilator-stimulated phosphoprotein 38
436674 AA725002 Hs 272018 low molecular mass ubiquinone-binding pr 38
408896 AI610447 Hs 48778 niban protein 38
425300 AW601773 Hs 270259 ESTs 38
432886 BE159028 Hs 279704 chromatin accessibility complex 1 38
424090 X99699 Hs 139262 XIAP associated factor-1 37
420202 AL036557 Hs 95910 putadve lymphocyte G0/G1 switch gene 37
427584 BE410293 Hs 179718 v-myb avian myeloblastosis viral oncogen 37
420579 AA278449 Hs 137429 ESTs 37
406038 Y14443 zinc finger protein 200 37
412590 AL134388 Hs 135033 ESTs, Weakly similar to I38022 hypotheti 37
406714 AI219304 Hs 266959 hemoglobin, gamma G 37
412014 AI620650 Hs 43761 ESTs, Weakly similar to A46010 X-lmked 37
419713 AW968058 Hs 92381 nudix (nucleoside diphosphate linked moi 37
449115 AW959952 Hs 37528 ESTs, Weakly similar to AF090944 1 PRO06 37
408955 BE315170 Hs 8087 Target CAT 37
441362 BE614410 Hs 23044 RAD51 (S cerevisiae) homolog (E cod Re 37
413774 AA131782 Hs 182314 ESTs 37
440225 BE295782 Hs 159 tumor necrosis factor receptor superfami 37
414528 AA148950 Hs 188836 ESTs 37
436137 AI056769 Hs 133512 ESTs 37
414733 BE514535 Hs 77171 minichromosome maintenance deficient (S 37
406785 AA588061 gb nk10d03 s1 NCI CGAP Co2 Homo sapiens 37
443361 AI792628 Hs 133273 ESTs 37
434868 R50032 Hs 159263 collagen, type VI, alpha 2 37
409557 BE182896 Hs 211193 ESTs 37
420300 AA258245 Hs 127573 Homo sapiens FKSG41 (FKSG41) mRNA compl 37
427695 R88483 Hs 172862 ESTs 37
407756 AA116021 Hs 38260 ubiquitin specific protease 18 36
437916 BE566249 Hs 20999 hypothetical protein FU23142 36
434563 AW083994 Hs 9469 pleckstnn homology domain-containing, f 36
444371 BE540274 Hs 239 forkhead box M1 36
437816 AI823445 Hs 280699 ESTs 36
405605 C2001342 gι|127814|sp|P26434|NAH4 RAT SO 36
444794 AI419991 Hs 145225 ESTs 36
430540 AW245422 Hs 106357 Homo sapiens cDNA FLJ22105 fis, clone H 36
429747 M87507 Hs 2490 caspase 1 apoptosis-related cysteine pr 36
453785 AI368236 Hs 283732 ESTs, Moderately similar to ALU1.HUMAN A 36
403267 Target Exon 36
440370 AA884000 Hs 8173 hypothetical protein FU10803 36
447497 AW167254 Hs 205722 ESTs 36
428600 AW863261 Hs 242413 hypothetical protein DKFZp434K1421 36
428715 AW293716 Hs 53126 ESTs 36
416097 BE387371 Hs 118964 hypothetical protein FLJ 20085 36
453438 AI469935 Hs 22792 ESTs 36
427299 AA830210 Hs 214263 ESTs, Moderately similar to ALU1.HUMAN A 36
434577 R37316 Hs 179769 Homo sapiens cDNA FU22487 fis, clone H 36
452785 AL359942 Hs 296434 erythroid differentiation and denuclead 36
434467 BE552368 Hs 231853 Homo sapiens cDNA FU13445 fis, clone PL 36
435523 T62849 Hs 11090 membrane-spanning 4-domaιns, subfamily A 36
418287 AI872319 Hs 78935 methionine aminopepddase, elF-2-assocιa 36
422156 N34524 gb yy56d10 s1 Soares.muldple.sclerosis. 36
441224 AU076964 Hs 7753 calumenin 36
458072 AI890347 Hs 271923 Homo sapiens cDNA FU22785 fis, clone K 36
435677 AA6941 2 Hs 293726 ESTs, Weakly similar to TSGA RAT TESTIS 36
433325 AW206986 Hs 143905 ESTs 36
420683 AA830168 Hs 271305 ESTs 36
443206 AB011420 Hs 9075 seπne/threonme kinase 17a (apoptosis-i 36
454078 AA601518 Hs 22209 secreted modular calcium-binding protein 36
404584 Target Exon 35
428311 NM 005651 Hs 183671 tryptophan 23-dιoxygenase 35
425922 AL157466 Hs 162751 Homo sapiens mRNA. cDNA DKFZp761E2423 (f 35
415131 D61119 gb HUM158C11 B Clontech human fetal brain 35
412971 AA889628 Hs 35125 ESTs 35
451593 AF151879 Hs 26706 CGI-121 protein 35
416427 BE244050 Hs 79307 Rac/Cdc42 guanine exchange factor (GEF) 35 427809 M26380 Hs 180878 lipoprotein lipase 35
443303 U67319 Hs 9216 caspase 7, apoptosis-related cysteine pr 35
422765 AW409701 Hs 1578 baculoviral IAP repeat-containing 5 (sur 35
445936 BE543594 Hs 61478 hypothedcal protein FLJ22329 35
411537 BE073250 gb MR0-BT0551 -060300-102-e05 BT0551 Homo 35
432250 AA452088 Hs 274170 Opa-interacdng protein 2 35
458438 AI141520 Hs 151464 ESTs, Weakly similar to ALUC_HUMAN "" 35
407253 AA411175 Hs 141939 ESTs, Moderately similar to S65657 alpha 35
410507 AA355288 Hs 76064 transitional epithelia response protein 35
412436 AA665089 gb nu76d01 s1 NCI.CGAP.Alv1 Homo sapiens 35
416933 BE561850 Hs 80506 small nuclear nbonucleoprotein polypept 35
437681 AI207958 Hs 166556 Homo sapiens, Similar to TEA domain fa i 35
408247 AA053451 Hs 225632 leucine zipper protein 3 35
440074 AA863045 Hs 10669 ESTs, Weakly similar to T00050 hypothed 35
422448 AW372922 Hs 116774 integnn, alpha 1 35
420676 AI434780 Hs 4248 vav 2 oncogene 35
417663 R07483 Hs 180461 ESTs 35
451089 AA903705 Hs 4190 Homo sapiens cDNA FU23269 fis, done C 35
451446 AI826288 Hs 171637 hypothedcal protein MGC2628 35
414727 BE466904 Hs 190162 gb hz28f03 x1 NCI.CGAP.GC6 Homo sapiens 35
421778 AA428000 Hs 283072 acdπ related protein 2/3 complex, subun 35
427413 BE547647 Hs 177781 hypothedcal protein MGC5618 35
414039 M83221 Hs 858 v-rel avian redculoendotheliosis viral 35
456304 AI820973 gb nc21c02 y5 NCI CGAP Pr1 Homo sapiens 35
449162 AI632740 Hs 10476 ESTs 35
437774 AW978199 Hs 291648 ESTs, Weakly similar to I38022 hypothed 35
426827 AW067805 Hs 172665 methylenetetrahydrofolate dehydrogenase 34
452203 X57522 transporter 1. ATP-bindmg cassette, sub 34
450325 AI935962 Hs 26289 ESTs 34
457211 AW972565 Hs 32399 ESTs, Weakly similar to S51797 vasodilat 34
419726 U50330 Hs 1274 bone morphogenedc protein 1 34
417409 BE272506 Hs 82109 syndecan 1 34
412811 H06382 ESTs 34
430758 T91568 Hs 270616 ESTs, Moderately similar to A34087 hypot 34
425769 U72513 Hs 159486 Human RPL13-2 pseudogene mRNA, complete 34
452682 AA456193 Hs 9071 progesterone membrane binding protein 34
429500 X78565 Hs 289114 hexabrachioπ (tenascin C, cytotacdn) 34
447674 BE270640 Hs 19192 cyclm-dependent kinase 2 34
443378 AW392550 Hs 9280 proteasome (proso e, macropain) subunit, 34
446134 AW161234 Hs 13993 TBP-like 1 34
418669 U85992 Hs 87197 Human clone IMAGE 35527 unknown protein 34
425006 R38685 Hs 222746 ESTs 34
435256 AF193766 Hs 13872 cytokme-like protein C17 34
453379 AA035261 Hs 61753 ESTs 34
448224 R48700 Hs 20733 Homo sapiens cDNA FU22356 fis, clone H 34
455899 BE155112 gb PM1-HT0350-151299-003-303 HT0350 Homo 34
422017 NM.003877 Hs 110776 STAT induced STAT ιnhιbιtor-2 34
417395 BE5~64245 Hs 82084 integnn beta 3 binding protein (beta3-e 34
405046 C3000978 gι|9280045|db|lBAB01579 1| (ABO 34
423178 AI033140 Hs 124983 Homo sapiens mRNA cDNA DKFZp564C142 (fr 34
455142 AW861840 gb CMO-CT0337-250200-243-g01 CT0337 Homo 34
418819 AA228776 Hs 191721 ESTs 34
428289 M26301 Hs 2253 complement component 2 34
412799 AI267606 gb aq91h03 x1 Stanley Frontal SB pool 1 34
403108 ENSP00000241415' Hypothedcal 677 kDa p 34
421637 AF035290 Hs 106300 Homo sapiens clone 23556 mRNA sequence 34
419373 NM 003244 Hs 90077 TG-interacdng factor (TALE family homeo 34
424408 AI754813 Hs 146428 collagen, type V, alpha 1 34
451061 AW291487 Hs 213659 ESTs, Weakly similar to KIAA1357 protein 34
433578 BE336886 Hs 3416 adipose differentiation-related protein 34
439867 AA847510 Hs 161292 ESTs 34
449249 T52285 Hs 193115 Homo sapiens mRNA for KIAA1764 protein, 34
420982 AW576160 Hs 100729 KIAA0692 protein 34
440826 AW383618 Hs 346256 ESTs, Moderately similar to ALU2.HUMAN A 34
427687 AW003867 Hs 1570 histamine receptor H1 34
400533 ENSP00000209376' PRED65 protein (Fragmen 33
436314 AI983409 Hs 189226 ESTs 33
418110 R43523 Hs 217754 hypothedcal protein FU22202 33
448140 AF146761 Hs 20450 BCM-like membrane protein precursor 33
402229 BE262804 mitochondπal πbosomal protein S2 33
410687 U24389 Hs 65436 lysyl oxidase-like 1 33
424614 X54486 Hs 151242 senne (or cysteine) proteinase inhibito 33
443338 R99575 Hs 302908 ESTs 33
433062 AK001757 Hs 281348 hypothedcal protein FU10895 33
405303 Target Exon 33
410889 X91662 Hs 66744 twist (Drosophila) homolog (acrocephalos 33
406673 M34996 Hs 198253 mapr histocompatibility complex, class 33
431721 AB032996 Hs 268044 KIAA1170 protein 33
426746 J03626 Hs 2057 undine monophosphate synthetase (orotat 33
425262 D87119 Hs 155418 GS3955 protein 33
424947 R77952 ESTs, Weakly similar to alternatively sp 33
437634 AW293046 Hs 255158 ESTs 33
437014 AA808757 Hs 222531 ESTs, Weakly similar to S59501 interfero 33 411688 AW953440 gb EST365510 MAGE resequences, MAGB Homo 33
447499 AW262580 Hs 147674 protocadheπn beta 16 33
432625 AI243596 Hs 94830 ESTs, Moderately similar to T03094 A-kin 33
435644 AA700867 Hs 269659 ESTs 33
406060 Target Exon 33
425018 BE245277 Hs 154196 E4F transcnpdon factor 1 33
450728 AW162923 Hs 25363 presenilin 2 (Alzheimer disease 4) 33
443105 X96753 Hs 9004 chondroidn sulfate proteoglycan 4 (mela 33
414799 AI752416 Hs 77326 insulin-like growth factor binding prote 33
435375 AI733610 Hs 187832 ESTs 33
432693 AW449630 Hs 293790 ESTs 33
449340 AW235786 Hs 195359 hypothedcal protein MGC10954 33
422530 AW972300 Hs 118110 bone marrow stromal cell andgen 2 33
448002 Y15227 Hs 20149 deleted in lymphocydc leukemia, 1 33
433160 AW207002 Hs 134342 TASP for testis-specific adnamycin sens 33
429125 AA446854 Hs 271004 ESTs, Weakly similar to I38022 hypothed 33
452526 W38537 Hs 280740 hypothedcal protein MGC3040 33
416664 H72780 Hs 20289 ESTs 33
444911 U06117 Hs 250 xanthene dehydrogenase 33
453544 AA831785 Hs 171914 Homo sapiens cONA FU14209 fis, clone NT 33
433042 AW193534 Hs 281895 Homo sapiens cDNA FU 11660 fis, clone HE 33
444046 AI360834 Hs 135094 ESTs 33
411373 BE326276 Hs 8861 ESTs 33
431865 AA521106 Hs 136375 ESTs, Weakly similar to S65824 reverse t 33
408116 AA251393 Hs 289052 Homo sapiens. Similar to RIKEN cDNA 5430 33
410006 AW732308 Hs 57783 eukaryodc translation initiation factor 33
442485 BE092285 Hs 29724 hypothedcal protein FU13187 33
416379 N38857 Hs 203933 ESTs 33
416308 AW291942 Hs 23628 3 beta-hydroxy-delta 5-C27-steroιd oxido 33
427954 J03060 Hs 247551 metaxin 1 33
459660 M79082 ESTs 33
419829 AI924228 Hs 115185 ESTs, Moderately similar to PC4259 fem 33
437945 T78519 gb yd68c08 r1 Soares fetal liver spleen 33
400850 Target Exon 33
457244 AA581385 Hs 162473 ESTs, Weakly similar to I38022 hypothed 33
430462 AI584156 Hs 105640 Homo sapiens, clone IMAGE 4139775, mRNA, 33
457653 AI820719 Hs 154662 DnaJ (Hsp40) homolog, subfamily A, membe 33
431836 AF178532 Hs 271411 beta-site APP-cleaving enzyme 2 32
440933 AI208217 Hs 142879 ESTs 32
418079 R40058 Hs 6911 ESTs 32
414280 BE410769 Hs 75873 zyxin 32
425295 AA431366 Hs 37251 ESTs 32
408872 AI476139 Hs 13291 ESTs 32
416857 AA188775 Hs 292453 ESTs 32
429599 AA806106 Hs 123664 ESTs 32
437437 AA226869 hypothetical protein DKFZp762L0311 32
434274 AA628539 Hs 116252 ESTs, Moderately similar to ALU1.HUMAN A 32
403349 NM 001406 ephπn-B3 32
449385 AI650471 Hs 347290 ESTs 32
431421 AW969118 Hs 108144 ESTs, Weakly similar to unnamed protein 32
419865 NM 007020 Hs 93502 U1-snRNP binding protein homolog (70kD) 32
410700 AA352335 Hs 65641 hypothedcal protein FU20073 32
432044 AW972727 gb EST384819 MAGE resequences MAGL Homo 32
412490 AW803564 Hs 288850 Homo sapiens cDNA FU22528 fis, clone H 32
408431 AI338631 Hs 43266 Homo sapiens cDNA FU22536 fis, clone H 32
430413 AW842182 Hs 241392 small inducible cytokine A5 (RANTES) 32
448789 BE539108 Hs 22051 hypothedcal protein MGC15548 32
439332 AW842747 Hs 300870 Homo sapiens mRNA, cDNA DKFZp547M072 (fr 32
418030 BE207573 Hs 83321 neuromedin B 32
428878 AA436884 Hs 48926 ESTs 32
451527 AF022813 Hs 26518 transmembrane 4 superfamily member 7 32
426406 AI742501 Hs 169756 complement component 1 , s subcomponent 32
448432 AI783586 Hs 208575 ESTs 32
433894 AI907682 Hs 243293 ESTs 32
436210 AI825420 Hs 197824 ESTs 32
433791 AA719352 Hs 112718 ESTs 32
450150 AI754391 Hs 23510 Kruppel-like factor 12 32
427513 AI476318 Hs 192480 ESTs 32
423789 AK002084 Hs 132851 hypothetical protein FLJ 11222 32
451350 AI791447 gb nι13a05 y5 NCI_CGAP_Co4 Homo sapiens 32
429065 AI753247 Hs 29643 Homo sapiens cDNA FLJ 13103 fis, clone NT 32
416784 AA334592 Hs 79914 lumican 32
406851 AA609784 mapr histocompadbility complex, class 32
428032 AW997704 Hs 11493 Homo sapiens cDNA FU 13536 fis, clone PL 32
412646 NM 006825 Hs 74368 transmembrane protein (63kD). endoplasmi 32
432065 AA401039 Hs 2903 protein phosphatase 4 (formeriy X), cata 32
415709 AA649850 Hs 278558 ESTs 32
422798 R92347 Hs 34574 ESTs, Weakly similar to ALU 1 HUMAN ALU S 32
437807 AI017875 Hs 136829 ESTs 32
425171 AW732240 Hs 16365 ESTs 32
448108 AW300021 Hs 170685 ESTs 32
402523 C1001173* gι|9743439|gb|AAF79932 2| (AF2 32
440146 AW014231 Hs 90790 Homo sapiens cDNA FU22930 fis, clone K 32 429415 NM 002593 Hs 202097 procollagen C-endopepddase enhancer 32
422081 AW136820 Hs 196011 ESTs 32
436258 AW867491 Hs 107125 plasmalemma vesicle associated protein 32
410886 AW809324 gb MR4-ST0121-141099-010-G06.1 ST0121 Ho 32
442609 AL020996 Hs 8518 seleπoprotem N 32
416188 BE157260 Hs 79070 v-myc avian myelocytomatosis viral oncog 32
441544 AW300043 Hs 127137 ESTs 32
437860 AA333063 Hs 279898 Homo sapiens cDNA FU23165 fis, clone L 32
419652 AL157485 Hs 91973 hypothetical protein 32
443623 AA345519 Hs 9641 complement component 1, q subcomponent 32
415198 AW009480 Hs 943 natural killer cell transcπpt 4 32
441701 AW339828 Hs 127497 ESTs 32
426384 AI472078 Hs 303662 hypothedcal protein FLJ13189 (FU13189) 32
420886 AA805453 ESTs, Weakly similar to T29012 hypothed 32
428896 AW291932 Hs 98936 ESTs 32
458253 AW296952 Hs 196802 ESTs 32
456895 AA354771 Hs 43047 Homo sapiens cDNA FU 13585 fis, clone PL 32
434818 AA650097 Hs 5996 ESTs 32
424278 AK000723 Hs 144517 hypothetical protein FU20716 32
434131 AI858275 Hs 143659 ESTs 32
447111 AI017574 Hs 17409 cysteine-πch protein 1 (mtesdnal) 31
443021 AA368546 Hs 8904 lg superfamily protein 3 1
416677 T83470 Hs 334840 ESTs, Moderately similar to 178885 senn 31
429973 AI423317 Hs 164680 ESTs 31
422545 X02761 Hs 287820 fibronecdn 1 3 1
444006 BE395085 Hs 10086 type I transmembrane protein Fn14 31
420116 NM.013241 Hs 95231 FH1/FH2 domain-containing protein 31
401841 NM.015113 Homo sapiens KIAA0399 protein 3 1
414416 AW409985 Hs 76084 hypothedcal protein MGC2721 31
431019 NM_005249 Hs 2714 forkhead box G1B 31
453707 AW003879 Hs 126522 Homo sapiens, clone MGC 16722, mRNA, com 3 1
432188 AI362952 Hs 2928 solute earner family 7 (cationic ammo 31
407378 AA299264 Hs 57776 ESTs, Moderately similar to I38022 hypot 3 1
430701 AI760833 Hs 293971 ESTs 3 1
429569 AA454993 Hs 138343 ESTs, Weakly similar to I78885 senne/th 3 1
458918 H56499 Hs 252692 ESTs, Weakly similar to I38022 hypothed 3 1
439764 T26535 Hs 22744 hypothetical protein MGC13105 31
452221 C21322 Hs 288057 hypothedcal protein FU 22242 31
403969 ENSP00000034663 Zinc finger protein 131 3 1
427359 AW020782 Hs 79881 Homo sapiens cDNA FU23006 fis clone L 3 1
414396 BE548266 Hs 76057 galactose-4-epιmerase, UDP- 3 1
444153 AK001610 Hs 10414 hypothedcal protein FU 10748 3 1
414403 AW969551 Hs 76064 πbosomal protein L27a 3 1
444168 AW379879 gb RC1 -HT0256-081199-011 -f01 HT0256 Homo 3 1
410595 AW629223 Hs 64794 zinc finger protein 183 (RING finger, C3 3 1
444881 AI623288 Hs 192805 ESTs 3 1
440381 AA917808 Hs 190495 ESTs 3 1
416207 NM.014745 Hs 79077 Homo sapiens, clone MGC 2908, mRNA, comp 31
439130 AA306090 Hs 124707 ESTs 3 1
457579 AB030816 Hs 36761 HRAS like suppressor 3 1
406736 AI254733 Hs 182426 πbosomal protein S2 31
420172 AA601122 Hs 95655 secreted and transmembrane 1 3 1
428060 AA420616 Hs 249483 ESTs 31
444143 AW747996 Hs 160999 ESTs, Moderately similar to A56194 throm 3 1
409154 U72882 Hs 50842 interferon-induced protein 35 3 1
449426 T92251 Hs 198882 ESTs 31
458760 AI498631 Hs 111334 femdn, light polypepbde 3 1
450811 AI739486 Hs 245497 ESTs 3 1
425331 AW962128 gb EST374201 MAGE resequences, MAGG Homo 31
445211 BE045601 Hs 118248 ESTs, Weakly similar to YC18 HUMAN HYPOT 3 1
441318 AI078234 Hs 176130 ESTs 31
450625 AW970107 gb EST382188 MAGE resequences, MAGK Homo 3 1
437640 AA764893 Hs 272155 ESTs, Weakly similar to I38022 hypotheti 31
444672 Z95636 HS 11669 laminin, alpha 5 3 1
407047 X65965 gb H sapiens SOD-2 gene for manganese su 3 1
413834 BE296896 Hs 224179 ESTs, Weakly similar to I38022 hypotheti 3 1
439755 AW748482 Hs 77873 B7 homolog 3 3 1
435520 AA297990 Hs 9315 HNOEL-iso protein 31
414598 AI094221 Hs 135150 lung type-l cell membrane-associated gly 3 1
440948 AW188311 Hs 128619 ESTs 31
412851 AI826502 Hs 106149 ESTs 3 1
417336 R70429 Hs 81988 disabled (Drosophila) homolog 2 (mitogen 3 1
417944 AU077196 Hs 82985 collagen, type V, alpha 2 31
411671 BE049094 ESTs 3 1
430444 AW296421 Hs 121035 ESTs 31
425843 BE313280 Hs 159627 death associated protein 3 3 1
407721 Y12735 Hs 38018 dual-specificity tyrosιπe-(Y)-phosphoryl 3 1
439093 AA534163 Hs 5476 Homo sapiens, clone IMAGE 3530123 mRNA, 31
449523 NM 000579 Hs 54443 chemokine (C-C modf) receptor 5 31
435664 AI032087 Hs 269819 ESTs 3 1
453085 AW954243 KIAA0251 protein 3 1
430314 AA369601 Hs 239138 pre-B-cell colony-enhancing factor 30
447527 AI702896 Hs 42091 ESTs 30 432682 AI376400 Hs 159588 ESTs 30
416941 BE000150 Hs 48778 mban protein 30
455481 AW948317 gb RC0-MT0015-280300-021-a09 MT0015 Homo 30
445906 N28939 Hs 13434 Homo sapiens clone 24418 mRNA sequence 30
408716 AI567839 Hs 151714 Homo sapiens mRNA for KIAA1769 protein. 30
424308 AW975531 Hs 154443 minichromosome maintenance deficient (S 30
436443 AW138211 Hs 128746 ESTs 30
425421 L11669 Hs 157145 tetracycline transporter-like protein 30
427725 U66839 Hs 180533 mitogen-acdvated protein kinase kinase 30
456816 AK001509 Hs 144391 hypothedcal protein FU10647 30
404632 NM 022490 Homo sapiens hypothetical prot 30
411565 AW851728 gb MR2-CT0222-011199-007-d06 CT0222 Homo 30
428917 AA437337 Hs 16689 ESTs 30
424584 H10692 Hs 13310 ESTs 30
452483 AI903731 Hs 106357 valosin-contaming protein 30
404453 C8000963* gι|6329915|db||BAA86452 1| (AB 30
426931 NM 003416 Hs 2076 zinc finger protein 7 (KOX 4, clone HF 1 30
455646 BE064420 gb RC4-BT0311-241199-012-C08 BT0311 Homo 30
452188 AI864208 Hs 176275 ESTs 30
409703 NM 006187 Hs 56009 2-5'-olιgoadenylate synthetase 3 (100 k 30
413922 AI535895 Hs 221024 ESTs 30
452367 U71207 Hs 29279 eyes absent (Drosophila) homolog 2 30
434070 AF116652 Hs 270087 hypothedcal protein PRO0813 30
406679 AA070786 gb zm66b07 r1 Stratagene neuroepithedum 30
414747 U30872 Hs 77204 centromere protein F (350/400kD, mitosin 30
435472 AW972330 Hs 283022 tnggenng receptor expressed on myeloid 30
429612 AF062649 Hs 252587 pituitary tumor-transforming 1 30
408989 AW361666 Hs 49500 KIAA0746 protein 30
418365 AW014345 Hs 161690 ESTs 30
418677 S83308 Hs 87224 SRY (sex determining region Y)-box 5 30
426765 AA743603 Hs 172108 nucleopoπn 88kD 30
400295 W72838 AI905687 IL-BT095-190199-019 BT095 Homo 30
429751 M55210 Hs 214982 laminin, gamma 1 (formeriy LAMB2) 30
429940 W25215 gb zb87a09 r1 Soares senescent fibroblas 30
412281 AI810054 Hs 14119 ESTs 30
434898 AW500458 Hs 29956 KIAA0460 protein 30
424830 AW270580 Hs 189311 ESTs, Weakly similar to putadve p150 [H 30
459727 AI906494 gb RC-BT113-060499-024 BT113 Homo sapien 30
453900 AW003582 Hs 226414 ESTs, Weakly similar to ALU8.HUMAN ALU S 30
458729 AI364504 Hs 93967 ESTs, Weakly similar to NBHUC8 decoπn p 30
402105 C18000230' gι|12585552|sp|Q9Y2Q1|Z257_HU 30
425248 AW957442 Hs 252766 ESTs 30
440995 T57773 Hs 10263 ESTs 30
441360 AI091713 Hs 106597 Homo sapiens, Similar to RIKEN cDNA 1110 30
432692 AW974944 Hs 200577 ESTs 30
428899 AA744610 Hs 194431 palladin 30
452811 AA937079 Hs 118983 hypothetical protein FLJ12150 30
447183 AI554733 Hs 173182 ESTs 30
429679 NM.006290 Hs 211600 tumor necrosis factor, alpha-induced pro 30
416505 H66470 Hs 16004 ESTs 30
420144 AA811813 Hs 119421 ESTs 30
439184 AW021842 Hs 16533 myosin phosphatase, target subunit 1 30
438033 T26483 Hs 6059 EGF-containing fibulm-like extracellula 30
442476 AF069475 gb AF069475 Homo sapiens astrocytoma lib 30
441035 AI694309 Hs 126458 ESTs 30
458810 BE407125 Hs 231510 ESTs 30
435046 AA662772 Hs 174330 ESTs, Weakly similar to ALU1_HUMAN ALU S 30
414271 AK000275 Hs 75871 protein kinase C binding protein 1 30
450879 AI742685 Hs 210347 ESTs 30
454036 AA374756 Hs 93560 Homo sapiens mRNA for KIAA1771 protein, 30
403780 C4001759 gι|133250|sp|P19474|RO52 HUMAN 30
411543 AW851248 gb IL3-CT0220-160200-066-F01 CT0220 Homo 30
440351 AF030933 Hs 7179 RAD1 (S pombe) homolog 30
452139 AA099969 Hs 16331 Homo sapiens cDNA FU21482 fis, clone C 30
449433 AI672096 Hs 9012 ESTs, Weakly similar to S26650 DNA-bmdi 30
413945 NM_000591 Hs 75627 CD14 andgen 30
433681 AI004377 Hs 200360 Homo sapiens cDNA FU13027 fis, clone NT 30
422605 H16646 Hs 118666 hypothedcal protein PP591 30
443502 AI074528 Hs 133949 ESTs 30
410781 AI375672 Hs 165028 ESTs 30
449428 AI651280 Hs 195685 ESTs 30
436671 AW137159 Hs 146151 ESTs 30
TABLE 16B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
408432 1058667 1 AW195262 R27868 AW811262
410886 1225822 1 AW809324 BE144977 BE144956
411537 1248899 1 BE073250 BE073378 BE073379 AW850533 AW850529
411543 1249127 1 AW851248 AW851425AW850805 AW851021 AW850905 411565 12497561 AW851728 AW851607 AW851621 AW851702 AW851647 AW851727 AW851658 AW851617 AW851628
411671 1253691 BE049094 AA700765 H86770 AA094646 R02483 C03868 N56170
411688 12540761 AW953440 T08189 AW857085
412436 1294391 AA665089 AA135130 AA484059 AA102419 AW877765
412799 1328171 AI267606 AA121045 AA126521
412811 132943.1 H06382 AW957730 AA352014 R13591 AA121201 D60420 BE263253 BE047862 Z41952 AI424991 AI693507 AI863108 AA599060 AI091148 AA598689
R39887 AA813482 AW016452 H06383 R41807 AI364268 AA620528 AI241940 AW089149 AW090733 AW088875 Z38240 AA121202 R17734
414372 1439091 AA143654 AW753140 AA213770 AW970865 AA569075 AA492132
415131 15236801 D61119 D81508 D81734
415688 1546431 AA166963 AW971218 AA493942
416871 1626761 1 H98716 N90792 N24283
416913 163001 1 AW934714 BE161007 BE162500 AW749902 AW749864 BE162498 BE161005 AA190449 AW513465 BE161006 BE162499
419896 18886621 Z99362 Z99363
420886 1973441 AA805453 AA281379
422156 212379.1 N34524 AA305071 AW954803 AA502335 AI433430 AI203597 AW026670 AW265323 AW850787 AA317554 AW993643 AW835572 AW385512
AI334966 W32951 H62656 H53902 R88904 AW835732
423713 2312901 AW754182AW754198 AA329983
424009 2341771 F11690 AW965370 AA333586 D30830
424947 2452471 R77952 AA348809 AW959960 AW959962 AI565552 AW070702 AA973910 R85973
425331 2501991 AW962128 AA355353 AA427363
429163 3005431 AA884766 AW974271 AA592975 AA447312
429940 3108841 W25215 AA461079AA461391
430968 3262691 AW972830 AA527647 AA489820 AA570362
432044 3407731 AW972727 AA524829 AW972733
432363 3454691 AA534489 AW970240 AW970323
435542 4077441 AA687376 H74234 AW975503
437437 43709.1 AA226869 AA296516 AW959753 AA186390 AL359619 AA356195 AA148427 R22748 AI033624 BE548853 H95327 AW579751 8E561649 AA397533
BE617136 AA236444 T89946 AA247450 N55777 W38725AI 743846 AI808406 AA922229 AI051464 W04713 R11251 W19656 AI042319 AA489276
AI224533 H
437945 445801 T78519 H59898 U72516
439518 473341 W76326 AF086341 W72300
439566 47387.1 AF086387 W77884 W72711
439710 475501 AF086543 W96291 W96225
442476 5435471 AF069475 AF069477 AF069476
444168 5938291 AW379879AI126285 H12014
449625 8113.1 NM.014253 AF100772 BE088769 AL022718 BE161779 AW863569 BE161640 AL039060 BE168542 AW296554 AA323193 AA235370 AW779760
N48674 AI375997 R45432059344 AI203107 F07491 R35360 R25094 AI913631 AI498402 T61382 AI016320 N45526 T61415 AA331486
450166 826771 AA429504 R41904 AA279467 H09648 AA007236
450375 83327.1 AA009647 AA131254 AA374293 AW954405 H04410 AW606284 AA151166 BE157467 BE157601 H04384 W46291 AW663674 H04021 H01532
AA190993 H03231 H59605 H01642 AA852876 AA113758 AA626915 AA746952 Al 161014 AA099554 R69067
450506 836.1 NM_004460 U09278 U76833 AW630055 AW471133 C02434 W45237 AW793518 BE070112 AI587479 AI624429 AW190535 AI446661 AI478772
AW022667 AA528235 AA599775 AW613820 AI435793 AW594230 AI051768 AI200109 AI680296 AA436611 AW609728 W42634 AI682584 AA405569
AI685653 AW0
450625 84032.1 AW970107 AA513951 AA010406 451129 859870.1 BE072881 BE072946 AI762181 451350 866945.1 AI791447 AI791327 AW886809 452203 903 2 X57522 AW295947 AI346197 AI304693 L21205 L21206 L21207 L21208 L21204 NM.000593 F06770 F12630 X57521 R18264 T74462 AA346259
AW602508 AA904076 F08426 H23432 AA313737 AA393782 M78052 AA847441 AA487637 AA135770 AA353161 AI819778 AA054458 AI346733
AW361447 AI4
453085 94851.1 AW954243 AA829930 AA412478 AA828434 AA814538 AI927418 AI192435 W52897 AA443666 AA031913 AI683306 AA918481 AI183314 D83907
AI206832 AA876122 D83836 D83838 D82533 AI761290 AI191125 AI143749 AW771909 AI241436 AI767267 W56507 AA847787 AA568692 T10502
AI247870
453331 96214 1 AI240665 T53681 N77468 H51833 AA147247 R75732 C18450 R73999 AI095755 T49904 H03868 AA411580 R33395 AA410586 T48869 D63292
R31981 H12498 H02668 AA035018 R75957 AI803329 R27528 R36203 AI809932 AI808765 R78948 AA411449 AA976929 AI378760 AI378620 T48870
R7390
453682 977454 1 T79703 T96307 AL079725 454860 1237732.1 AW835767 AW835537 BE160187 455142 1254887.1 AW861840 AW858329 AW858192 AW858189 AW858224 AW858351 455481 1293182.1 AW948317 AW948322 AW948329 AW948316 AW948298 AW948330 AW948325 AW948324 455646 1348557.1 BE064420 BE064435 BE064429 BE064414 BE064400 BE064517 455899 1381547.1 BE155112 BE155154 BE155087 BE155247 BE155499 BE155367 BE155452 456304 176820.1 AI820973 AI734077 AI820984 AA225796 AA225060 AA225101 457876 42814.2 AI821940 N67106 AI744264 AA808846 AA643417 AA643416 Z70715
TABLE 16C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham et al " refers to the publication entitled 'The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted Nt_posιdon Indicates nucleodde posidons of predicted exons
Pkey Ref Strand Nt position
400533 6981826 Minus 277132-277595
400850 1927150 Minus 4506-4691
401454 9186923 Minus 114659-114832
401841 7684597 Plus 89868-90006,91920-92085
402082 8117478 Minus 190046-190183
402105 8131588 Minus 22856-24055
402229 9965022 Minus 15739-15951,16166-16779
402239 7690131 Plus 38175-38304,42133-42266
402274 2935596 Plus 5604-6527
402523 9798518 Minus 18729-19283
402604 9909420 Plus 20393-20767 402855 9662953 Minus 59763-59909
403011 6693597 Minus 3468-3623
403108 8980955 Plus 93253-93667
403267 7887182 Plus 116078-121885
403349 8569773 Minus 167815-168374
403361 8570313 Minus 112496-112687
403481 9965004 Plus 93496-93633
403696 3135242 Minus 143467-143634
403780 8076989 Plus 93160-93409
403849 7708855 Plus 95043-96519
403961 7596976 Minus 110393-110603
403969 8569909 Plus 31237-31375,32405-32506
404209 5006246 Minus 11247-11514
-JD4407 7329316 Minus 48154-48499
404453 7657714 Plus 27768-29179
404584 9857511 Plus 138651-139153
404632 9796668 Plus 45096-45229
405046 7596829 Minus 4373-4528
405141 8980911 Plus 99861-100054
405303 2078453 Minus 130607-130802
405348 2914717 Minus 43310-43462
405558 1621110 Plus 4502-4644,5983-6083
405605 5836195 Minus 117070-117270
406038 8389537 Plus 37764-37877
406060 6899623 Minus 20339-20746
406478 9857502 Plus 68314-68523,68853-68950
TABLE 17A ABOUT 1040 GENES UP-REGULATED IN GLIOBLASTOMA MULTIFORMA COMPARED TO NORMAL ADULT TISSUES
Table 17A lists about 1040 genes up-regulated in glioblastoma muldforma (GBM) compared to normal normal adult dssues These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the rado of "average" glioblastoma to "average" normal dssues was greater than or equal to 30 The "average* GBM level was set to the 85"' percendle amongst vaπous GBM tumors The "average" normal dssue level was set to the 85*' percendle amongst vaπous non-malignant adult dssues In order to remove gene specific background levels of non-specific hybπdizadon, the 10* percendle value amongst the vaπous non-malignant dssues was subtracted from both the numerator and the denominator before the rado was evaluated
Pkey Unique Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene due
R1 Rado of GLIOBLASTOMA MULTIFORMA compared to NORMAL ADULT TISSUES
Pkey ExAccn UnigenelD Unigene Title R1
431917 D16181 Hs 2868 penpheral myelin protein 2 579
428321 AI699994 Hs 2868 penpheral myelin protein 2 50 1
427343 AI880044 Hs 176977 protein kinase C binding protein 2 496
413472 BE242870 Hs 75379 solute earner family 1 (glial high affi 439
415817 U88967 Hs 78867 protein tyrosine phosphatase, receptor-t 429
435147 AL133731 Hs 4774 Homo sapiens mRNA cDNA DKFZp761C1712 (f 42 5
430838 N46664 Hs 169395 hypothedcal protein FU12015 379
418375 NM 003081 Hs 84389 syπaptosomal-associated protein, 25kD 37 1
449494 AW237014 Hs 315369 Homo sapiens cDNA FLJ23075 fis, clone L 370
425088 AA663372 Hs 169395 hypothetical protein FU12015 32 7
425842 AI587490 Hs 159623 NK-2 (Drosophila) homolog B 324
419078 M93119 Hs 89584 insulmoma-associated 1 32 1
423849 AL157425 Hs 133315 Homo sapiens mRNA, cDNA DKFZp761J1324 (f 299
409389 AB007979 Hs 301281 Homo sapiens mRNA, chromosome 1 specific 288
413333 M74028 Hs 75297 fibroblast growth factor 1 (acidic) 28 5
417183 R52089 Hs 172717 ESTs 27 6
426325 D28114 Hs 169309 myelin-associated oligodendrocyte basic 276
412733 AA984472 Hs 74554 KIAA0080 protein 259
422656 AI870435 Hs 1569 LIM homeobox protein 2 256
436878 BE465204 Hs 47448 ESTs 249
437204 AL110216 Hs 22826 ESTs, Weakly similar to 155214 salivary 243
429007 D80642 gb HUM092E09B Human fetal brain (TFujiwa 231
429276 AF056085 Hs 198612 G protein-coupled receptor 51 231
409395 U46745 Hs 336678 dystrobrevm, alpha 230
435708 AI362949 Hs 75169 ESTs 22 5
453392 U23752 Hs 32964 SRY (sex determining region Y)-box 11 222
431941 AK000106 Hs 272227 Homo sapiens cDNA FU20099 fis, clone CO 22 1
418110 R43523 Hs 217754 hypothetical protein FU22202 220
416829 AB013805 Hs 80220 catenin (cadhenπ-associated protein), d 21 7
444513 AL120214 HS 7117 glutamate receptor, lonotropic, AMPA 1 209
433551 AI985544 Hs 12450 protocadhenn 9 198
452744 AI267652 Hs 246107 Homo sapiens mRNA cDNA DKFZp434E082 (fr 19 1
425057 AA826434 Hs 1619 achaete-scute complex (Drosophila) homol 190
429903 AL134197 Hs 93597 cyclin-dependent kinase 5, regulatory su 190
447004 AW296968 Hs 157539 ESTs 186
425048 H05468 Hs 164502 ESTs 182
427897 NM.017413 Hs 303084 apelin peptide ligand for APJ receptor 180
421264 AL039123 Hs 103042 microtubule associated protein 1B 180
453642 AI370936 Hs 34074 dipepddylpepddase VI 178
424140 Z48051 Hs 141308 myelin oligodendrocyte glycoprotein 17 7
444471 A8020684 Hs 11217 KIAA0877 protein 176
441350 AB020690 Hs 7782 paraneoplasdc antigen MA2 172
430691 C14187 Hs 103538 ESTs 167 433800 AI034361 Hs 135150 lung type-l cell membrane-associated gly 166
424581 M62062 Hs 150917 catenin (cadheπn associated protein), a 166
408562 AI436323 Hs 31141 Homo sapiens mRNA for KIAA1568 protein, 16 5
423853 AB011537 Hs 133466 slit (Drosophila) homolog 1 164
431019 NM 005249 Hs 2714 forkhead box G1B 164
449539 W80363 Hs 58446 ESTs 164
450133 AW969769 Hs 105201 ESTs 16 1
425799 T08133 Hs 182906 Homo sapiens mRNA for KIAA1872 protein, 160
447359 NM 012093 Hs 18268 adenylate kinase 5 154
415910 U20350 Hs 78913 chemokine (C-X3-C) receptor 1 15 3
459516 AI049662 Hs 246858 EST 149
456759 BE259150 Hs 127792 delta (DrosophilaJ-dke 3 147
429466 M85835 Hs 12827 ESTs 147
439979 AW600291 Hs 6823 hypothetical protein FU 10430 14 7
443785 AW449952 Hs 190125 basic-helix-loop-helix-PAS protein 146
439415 F05538 Hs 4273 ESTs 145
408604 D51408 Hs 21925 ESTs 14 5
444378 R41339 Hs 47860 neurotrophic tyrosine kinase, receptor, 14 3
428392 H10233 Hs 2265 secretory granule, neuroendocnne protei 140
418738 AW388633 Hs 6682 solute earner family 7, (cadonic ammo 140
409799 D11928 Hs 76845 phosphosenne phosphatase- ke 139
439239 AI031540 Hs 235331 ESTs 138
428342 AI739168 Homo sapiens cDNA FU 13458 fis, clone PL 137
448595 AB014544 Hs 21572 KIAA0644 gene product 136
441285 NM.002374 Hs 167 microtubule-associated protein 2 13 5
428982 NM 005097 Hs 194704 leucine-nch, glioma inacdvated 1 134
441440 AI807981 Hs 30495 ESTs 130
412959 D87458 Hs 75090 KIAA0282 protein 128
413597 AW302885 Hs 117183 ESTs 128
441016 AW138653 Hs 25845 ESTs 127
418338 NM 002522 Hs 84154 neuronal pentraxin 1 126
423419 R55336 Hs 23539 ESTs 126
445495 BE622641 Hs 38489 ESTs, Weakly similar to 138022 hypothed 126
441497 R51064 Hs 23172 ESTs 124
424893 AW295112 Hs 153648 Homo sapiens cDNA FU 13303 fis, clone OV 122
453941 U39817 Hs 36820 Bloom syndrome 122
427701 AA411101 Hs 243886 nuclear autoandgenic sperm protein (his 12 2
446782 AI653048 Hs 144006 ESTs 12 1
437268 AI754847 Hs 227571 regulator of G-protem signalling 4 121
411411 AA345241 Hs 55950 ESTs, Weakly similar to KIAA1330 protein 11 9
448302 AI480208 Hs 182906 Homo sapiens mRNA for KIAA1872 protein, 11 9
407034 U84540 gb Human dystrobrevm isoform DTN-3 (DTN 11 9
449625 NM 014253 odz (odd Oz/ten-m, Drosophila) homolog 1 11 7
451099 R52795 Hs 25954 interieukin 13 receptor, alpha 2 11 7
424432 AB037821 Hs 146858 protocadheπn 10 11 6
451996 AW514021 Hs 245510 ESTs 11 4
423678 AW963357 Hs 7847 ESTs 11 4
445041 T64183 Hs 282982 solute earner 11 3
442613 AI004002 Hs 130522 Kv channel-interacting protein 1 11 2
419721 NM 001650 Hs 288650 aquapoπn 4 11 2
446711 AF169692 Hs 12450 protocadhenn 9 11 1
412986 X81120 Hs 75110 cannabinoid receptor 1 (brain) 11 0
412140 AA219691 Hs 73625 RAB6 interacting kmesin-like (rabkines 107
428728 NM 016625 Hs 191381 hypothedcal protein 106
415849 R20529 Hs 6806 ESTs 106
447198 061523 Hs 283435 ESTs 105
420602 AF060877 Hs 99236 regulator of G-protem signalling 20 103
435793 AB037734 Hs 4993 KIAA1313 protein 103
409049 AI423132 Hs 146343 ESTs 102
449611 AI970394 Hs 197075 ESTs 102
402604 Target Exon 10 1
434277 X77748 Hs 3786 glutamate receptor, metabotropic 3 100
440435 AL042201 Hs 21273 transcnpdon factor NYD-sp10 100
438080 AA777381 Hs 291530 ESTs, Weakly similar to ALUC HUMAN »« 100
419271 N34901 Hs 238532 ESTs 99
426344 H41821 Hs 322469 transcπpdonal activator of the c-fos p 98
449605 AW138581 Hs 198416 ESTs 98
408081 AW451597 Hs 167409 ESTs 98
452526 W38537 Hs 280740 hypothetical protein MGC3040 98
411305 BE241596 Hs 69547 myelin basic protein 98
443455 AB001025 Hs 9349 ryanodine receptor 3 98
427540 R12014 Hs 20976 ESTs 97
424790 AL119344 Hs 13326 ESTs Weakly similar to 2004399A chromos 97
416892 L24498 Hs 80409 growth arrest and DNA-damage-inducible, 96
452461 N78223 Hs 108106 transcπption factor 96
449433 AI672096 Hs 9012 ESTs, Weakly similar to S26650 DNA-bindi 96
454027 R40192 Hs 21527 Human DNA sequence from clone GS1-115M3 95
439199 R40373 Hs 26299 ESTs 95
433896 AW294729 Hs 274461 ESTs 93
416072 AL110370 Hs 79000 growth associated protem 43 93
444119 R41231 Hs 184261 ESTs, Weakly similar to T26686 hypotheti 92
435624 AF218942 Hs 24889 formm 2 92
412788 AA120960 Hs 198416 ESTs 92 409902 AI337658 Hs 156351 ESTs 92
427304 AA761526 Hs 163853 ESTs 92
429918 AW873986 Hs 119383 ESTs 91
442910 AI365130 Hs 11307 ESTs, Weakly similar to T19326 hypotheti 9 1
425187 AW014486 Hs 22509 ESTs 9 1
436954 AA740151 Hs 130425 ESTs 91
442710 AI015631 Hs 23210 ESTs 91
411078 AI222020 Hs 182364 CocoaCπsp 90
438209 AL120659 Hs 6111 aryl-hydrocarbon receptor nuclear transl 90
437036 AI571514 Hs 133022 ESTs 90
448672 AI955511 Hs 225106 ESTs 90
451952 AL120173 Hs 301663 ESTs 89
448743 AB032962 Hs 21896 KIAA1136 protein 89
412068 S72043 Hs 73133 metallothionein 3 (growth inhibitory tac 89
439451 AF086270 Hs 278554 heterochromadn-like protein 1 88
419088 AI538323 Hs 52620 integnn, beta 8 88
445873 AA250970 Hs 251946 poly(A)-bιπdιπg protein, cytoplasmic 1-1 88
410102 AW248508 Hs 279727 ESTs, homologue of PEM-3 (Oona savignyi 88
449571 AW016812 Hs 200266 ESTs 87
425354 U62027 Hs 155935 complement component 3a receptor 1 87
452355 N54926 Hs 29202 G protein-coupled receptor 34 87
410276 AI554545 Hs 68301 angιopoιebn-2 87
435501 AW051819 Hs 129908 KIAA0591 protein 86
407728 AW071502 Hs 175931 ESTs 86
415293 R49462 Hs 106541 ESTs 86
416857 AA188775 Hs 292453 ESTs 86
425234 AW152225 Hs 165909 ESTs, Weakly similar to I38022 hypothed 85
450375 AA009647 a dismtegnn and metalloproteinase doma 85
413063 AL035737 Hs 75184 chidnase 3-lιke 1 (cartilage glycoprote 84
438380 T06430 Hs 6194 chondroidn sulfate proteoglycan BEHAB/b 84
421659 NM 014459 Hs 106511 protocadhenn 17 84
418097 R45137 Hs 21868 ESTs 83
429183 AB014604 Hs 197955 KIAA0704 protein 82
424945 AI221919 hypothetical protein FU10582 82
455601 AI368680 Hs 816 SRY (sex determining region Y)-box 2 82
453884 AA355925 Hs 36232 KIAA0186 gene product 82
407881 AW072003 Hs 40968 heparan sulfate (glucosamme) 3-O-sulfot 81
436887 AW953157 Hs 193235 hypothedcal protein DKFZp547D155 81
431721 AB032996 Hs 268044 KIAA1170 protein 8 1
417160 N76497 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbac 8 1
409041 AB033025 Hs 50081 Hypothetical protein, XP J51860 (KIAA119 8 1
424085 NM 002914 Hs 139226 replicadon factor C (acdvator 1) 2 (40 8 1
436039 AW023323 Hs 121070 ESTs 80
449444 AW818436 Hs 23590 solute earner family 16 (monocarboxylic 80
427463 AA442224 Hs 97900 ESTs 80
440184 AB002297 Hs 7022 dedicator of cyto-kmesis 3 79
409731 AA125985 Hs 56145 thymosin, beta, idendfied in neuroblast 78
451621 AI879148 Hs 26770 fatty acid binding protein 7, brain 77
419929 U90268 Hs 93810 cerebral cavernous malformations 1 77
419544 AI909154 gb QV-BT200-010499-007 BT200 Homo sapien 77
448555 AI536697 Hs 159863 ESTs 77
414372 AA143654 gb zo65a02 r1 Stratagene pancreas (93720 77
438527 AI969251 Hs 115325 RAB7, member RAS oncogene family-like 1 77
400293 N51002 Hs 306480 Homo sapiens mRNA, cDNA DKFZp761 E2112 (f 77
420362 U79734 Hs 97206 hundngdn interacting protein 1 76
430132 AA204686 Hs 234149 hypothedcal protein FU20647 75
448543 AW897741 Hs 21380 Homo sapiens mRNA, cONA DKFZp586P1124 (f 75
436140 W87355 Hs 269587 ESTs 74
449340 AW235786 Hs 195359 hypothedcal protein MGC10954 74
446372 AB020644 Hs 14945 long fatty acyl-CoA synthetase 2 gene 74
454117 BE410100 Hs 40368 adaptor-related protein complex 1 , Sigma 74
410434 AF051152 Hs 63668 toll-like receptor 2 74
454048 H05626 Hs 6921 ESTs 74
441523 AW51 263 Hs 301771 ESTs Weakly similar to ALUF_HUMAN «» 74
440074 AA863045 Hs 10669 ESTs, Weakly similar to T00050 hypothed 74
438330 AW450572 Hs 257316 ESTs 74
433556 W56321 Hs 111460 calcium/calmodulin-dependent protein km 73
434808 AF155108 Hs 256150 Homo sapiens, Similar to RIKEN cDNA 2810 73
445900 AF070526 Hs 125036 Homo sapiens clone 24787 mRNA sequence 73
402855 NM_001839* Homo sapiens calponin 3, acid 72
422960 AW890487 Hs 63984 cadheπn 13, H-cadhenn (heart) 72
439772 AL365406 Hs 10268 Homo sapiens mRNA full length insert cDN 72
433447 U29195 Hs 3281 neuronal pentraxin II 72
412709 AL022327 Hs 74518 KIAA0O27 protein 72
445745 A8007924 Hs 13245 KIAA0455 gene product 72
447101 N72185 Hs 44189 ESTs 72
448935 AL078596 Hs 22591 nuclear receptor subfamily 2, group E, m 7 1
409248 AB033035 Hs 51965 KIAA1209 protein 7 1
452785 AL359942 Hs 296434 erythroid differentiation and deπuclead 71
424998 U58515 Hs 154138 chidnase 3-lιke 2 7 1
436607 AW661783 Hs 211061 ESTs 71
447197 R36075 gb yh88b01 s1 Soares placenta Nb2HP Homo 7 1
419249 X14767 Hs 89768 gamma-aminobutync acid (GABA) A recepto 7 1 416111 AA033813 Hs 79018 chromadπ assembly factor 1, subunit A ( 7 1
421633 AF121860 Hs 106260 sorting nexm 10 70
428976 AL037824 Hs 194695 ras homolog gene family, member I 70
444783 AK001468 Hs 62180 anillm (Drosophila Scraps homolog), act 70
408096 BE250162 Hs 83765 dihydrofolate reductase 70
426269 H15302 Hs 168950 Homo sapiens mRNA, cDNA DKFZp566A1046 (f 69
439978 BE139460 Hs 124673 Homo sapiens cDNA FLJ11477 fis, clone HE 69
439570 T79925 Hs 269165 ESTs, Weakly similar to ALU1.HUMAN ALU S 69
422980 N46569 Hs 76722 CCAAT/enhancer binding protein (C/EBP), 69
415279 F04237 Hs 1447 glial fibrillary acidic protein 69
456965 AW131888 Hs 172792 ESTs, Weakly similar to hypothedcal pro 69
447773 AI423930 Hs 36790 ESTs, Weakly similar to putadve p150 [H 69
429927 NM_001115 Hs 2522 adenylate cyclase 8 (brain) 69
447499 AW262580 Hs 147674 protocadheπn beta 16 68
414696 AF002020 Hs 76918 Niemann-Pick disease, type C1 68
441255 R06350 Hs 171635 ESTs 68
429656 X05608 Hs 211584 neurofilament, light polypepdde (68kD) 68
439566 AF086387 gb Homo sapiens full length insert cDNA 68
435191 R15912 Hs 817 Homo sapiens clone 24461 mRNA sequence 68
420285 AA258124 Hs 293878 ESTs, Moderately similar to ZN91.HUMAN Z 68
430968 AW972830 gb EST384925 MAGE resequences, MAGL Homo 68
458332 AI000341 Hs 220491 ESTs 68
449048 Z45051 Hs 22920 similar to S68401 (cattle) glucose indue 67
413627 BE182082 Hs 246973 ESTs 67
415079 R43179 Hs 22895 hypothedcal protein FLJ23548 67
418677 S83308 Hs 87224 SRY (sex determining region Y)-box 5 67
432281 AK001239 Hs 274263 hypothetical protein FU10377 67
425741 AF052152 Hs 159412 Homo sapiens clone 24628 mRNA sequence 67
421141 AW117261 Hs 125914 ESTs 66
408829 NM 006042 Hs 48384 heparan sulfate (glucosamine) 3-O-sulfot 66
432154 AI701523 Hs 112577 ESTs 66
425202 AW962282 Hs 152049 ESTs, Weakly similar to I38022 hypothed 66
434164 AW207019 Hs 148135 seπne/threoπine kinase 33 66
407182 AA312551 Hs 230157 ESTs 66
445034 AW293376 Hs 143659 ESTs 66
410909 AW898161 Hs 53112 ESTs, Moderately similar to ALU8.HUMAN A 66
441102 AA973905 intermediate filament protein syncoiliπ 66
452834 AI638627 Hs 105685 KIAA1688 protein 66
429239 AA448419 Hs 45209 ESTs 66
414175 AI308876 Hs 103849 hypothetical protein DKFZp761D112 65
449300 AI656959 Hs 346514 ESTs 65
446727 AB011095 Hs 16032 KIAA0523 protein 65
429250 H56585 Hs 198308 tryptophan nch basic protein 65
420560 AW207748 Hs 59115 ESTs 65
448321 NM.005883 Hs 20912 adenomatous polyposis cod like 65
441390 AI692560 Hs 131175 ESTs 65
407168 R45175 Hs 117183 ESTs 64
447414 D82343 Hs 74376 neuroblastoma (nerve dssue) protein 64
407235 D20569 Hs 169407 SAC2 (suppressor of acdπ mutadons 2 y 64
433597 AA708205 Hs 100343 ESTs 64
414528 AA148950 Hs 188836 ESTs 64
414214 D49958 Hs 75819 glycoprotein M6A 64
446692 Z44514 Homo sapiens mRNA for KIAA1763 protein, 64
407896 D76435 Hs 41154 Zic family member 1 (odd-paired Drosophi 64
440152 AB002376 Hs 7006 KIAA0378 protein 64
453785 AI368236 Hs 283732 ESTs, Moderately similar to ALU1.HUMAN A 63
412530 AA766268 Hs 266273 hypothedcal protein FU13346 63
448902 Z45998 Hs 22543 Homo sapiens mRNA, cDNA DKFZp761H912 (f 63
452799 AI948829 Hs 213786 ESTs 63
425523 AB007948 Hs 158244 KIAA0479 protein 63
444396 T65213 Hs 4257 ESTs 63
422094 AF129535 Hs 272027 F-box only protein 5 63
420649 AI866964 Hs 124704 ESTs, Moderately similar to S65657 alpha 63
424028 AF055084 Hs 153692 Homo sapiens cDNA FU14354 fis, clone Y7 63
447350 AI375572 Hs 172634 ESTs 62
448148 NM 016578 Hs 20509 HBV pX associated proteιn-8 62
436936 AL134451 Hs 197478 ESTs 62
448243 AW369771 Hs 52620 integnn, beta 8 62
414727 BE466904 Hs 190162 gb hz28f03 x1 NCI CGAP GC6 Homo sapiens 62
420608 BE548277 Hs 103104 ESTs 62
422949 AA319435 gb EST21657 Adrenal gland tumor Homo sap 62
418506 AA084248 Hs 85339 G protein-coupled receptor 39 6 1
428242 H55709 Hs 2250 leukemia inhibitory factor (chol ergic 6 1
423361 AW170055 Hs 47628 ESTs 6 1
417417 F05745 Hs 89512 ATPase, Ca transporting plasma membrane 6 1
447072 D61594 Hs 17279 tyrosylprotem sutfotransferase 1 6 1
415651 AI207162 Hs 3815 slathmιn-lιke-proteιn RB3 60
418030 BE207573 Hs 83321 neuromedin 8 60
429469 M64590 Hs 27 glycine dehydrogenase (decarboxyladng, 60
417873 BE266659 Hs 293659 Homo sapiens Similar to RIKEN cDNA A430 60
429900 AA460421 Hs 30875 ESTs 60
416439 AA180363 Hs 118769 ESTs 60
439845 AL355743 Hs 56663 Homo sapiens EST from clone 41214, full 60 425905 A8032959 Hs 318584 novel C3HC4 type Zinc finger (πng finge 60
439518 W76326 gb zd60d04 r1 Soares_fetal_heart.NbHH19W 60
426919 AL041228 ELAV (embryonic lethal, abnormal vision, 60
440492 R39127 Hs 21433 hypothedcal protein DKFZp547J036 59
432328 AI572739 Hs 195471 6-phosphofructo-2-kιnase/fructose-2,6-bι 59
444190 AI878918 Hs 10526 Cysteine and glyc e-nch protein 2 59
425984 AW836277 Hs 165636 hypothedcal protein DKFZp761C07121 59
425977 R15138 Hs 165570 Homo sapiens clone 25052 mRNA sequence 59
449318 AW236021 Hs 78531 Homo sapiens, Similar to RIKEN cDNA 5730 59
457465 AW301344 Hs 122908 DNA replication factor 59
453362 H14988 Hs 107375 ESTs 59
453924 R49295 Hs 24886 ESTs 59
414825 X06370 Hs 77432 epidermal growth factor receptor (avian 58
433701 AW445023 Hs 15155 ESTs 58
412777 AI335773 Hs 270123 ESTs 58
419723 AL120193 Hs 339810 longevity assurance (LAG1, S cerevisiae 58
438054 AA776626 Hs 169309 ESTs 58
416427 BE244050 Hs 79307 Rac/Cdc42 guanine exchange factor (GEF) 58
400292 AA250737 Hs 72472 BMP-R1B 58
407748 AL079409 Hs 38176 KIAA0606 protein, SCN Orcadian Oscillat 58
453313 BE005771 Hs 153746 hypothedcal protein FU22490 58
430188 AL049242 Hs 234794 Homo sapiens mRNA, cDNA DKFZp564B083 (ft 58
411252 AB018549 Hs 69328 MD-2 protein 58
448986 H42169 Hs 347310 hypothedcal protein FU 14627 57
440052 AI633744 Hs 195648 ESTs, Weakly similar to I38022 hypothed 57
419704 AA429104 Hs 45057 ESTs 57
420077 AW512260 Hs 87767 ESTs 57
448966 AW372914 Hs 86149 phosphoinositol 3-phosphate-bιndιng prot 57
436511 AA721252 Hs 291502 ESTs 57
424560 AA158727 Hs 150555 protein predicted by clone 23733 57
423346 AI267677 Hs 127416 synaploianin 1 57
439249 AF086060 Hs 170053 G-protem coupled receptor 88 57
428588 F12101 Hs 185701 Homo sapiens mRNA full length insert cDN 57
450927 AI807804 Hs 134342 TASP for testis-specific adπamycin sens 57
451752 AB032997 Hs 26966 KIAA1171 protein 57
458814 AI498957 Hs 170861 ESTs, Weakly similar to Z195_HUMAN ZINC 56
416406 D86961 Hs 79299 lipoma HMGIC fusion partner-like 2 56
448275 BE514434 Hs 20830 kmesiπ-like 2 56
413492 D87470 Hs 75400 KIAA0280 protein 56
444600 R41398 Hs 6996 ESTs 56
421988 AW450481 Hs 161333 ESTs 56
443297 AI049864 Hs 133029 ESTs 56
433244 AB040943 Hs 271285 KIAA1510 protein 55
458809 AW972512 Hs 20985 sιn3-assocιated polypepdde, 30kD 55
448499 BE613280 Hs 77550 hypothedcal protein MGC1780 55
447458 AI741082 Hs 158961 ESTs 55
436643 AA757626 Hs 10941 ESTs, Weakly similar to IPP1 HUMAN PROTE 55
407886 AW969688 Hs 100826 ESTs 55
448944 AB014605 Hs 22599 atrophιn-1 iπteracdng protem 1, acdvi 55
418630 AI351311 Hs 251946 poly(A)-bιndιng protein, cytoplasmic 1-1 55
415734 NM 014747 Hs 78748 KIAA0237 gene product 55
410099 AA081630 KIAA0036 gene product 55
453128 AW026516 Hs 31791 acylphosphatase 2 muscle type 55
444670 H58373 Hs 332938 hypothedcal protein MGC5370 55
420345 AW295230 Hs 25231 ESTs 55
420092 AA814043 Hs 88045 ESTs 55
414821 M63835 Hs 77424 Fc fragment of IgG, high affinity la, re 54
429876 AB028977 Hs 225974 KIAA1054 protein 54
41S863 AW952691 Hs 93485 Homo sapiens mRNA, cDNA DKFZp761 D191 (fr 54
429149 AW193360 Hs 197962 ESTs, Weakly similar to I38022 hypotheti 54
415486 H12214 Hs 13284 ESTs, Weakly similar to 2109260A B cell 54
429643 AA455889 Hs 167279 FYVE-finger-containing Rab5 effector pro 54
446657 AI335191 Hs 260702 ESTs, Weakly similar to 2109260A B cell 54
439662 H97552 Hs 269060 ESTs 54
444165 AL137443 Hs 10441 hypothedcal protein FLJ 11236 54
439192 AW970536 Hs 105413 ESTs 53
448769 N66037 Hs 38173 ESTs 53
410555 U92649 Hs 64311 a dismtegnn and metalloproteinase doma 53
424922 BE386547 Hs 217112 hypothetical protein MGC10825 53
423905 AW579960 Hs 135150 lung type-l cell membrane-associated gly 53
429433 AA452899 Hs 213586 ESTs, Weakly similar to KIAA1353 protein 53
427359 AW020782 Hs 79881 Homo sapiens cDNA FU23006 fis, clone L 53
422544 AB018259 Hs 118140 KIAA0716 gene product 53
420547 AF155140 Hs 98738 gonadoUopin-regulated tesdcular RNA he 53
424624 AB032947 Hs 151301 Ca2+dependent activator protein for seer 52
441797 AI936933 Hs 214635 ESTs 52
428832 AA578229 Hs 324239 ESTs, Moderately similar to ZN91 HUMAN Z 52
418079 R40058 Hs 6911 ESTs 52
445740 T78281 Hs 13226 Homo sapiens clone 25181 mRNA sequence 52
416426 AA180256 Hs 210473 Homo sapiens cDNA FU14872 fis, clone PL 52
436109 AA922153 Hs 132760 hypothedcal protein MGC15729 52
433647 AA603367 Hs 222294 ESTs 52
452786 R61362 Hs 106642 ESTs, Weakly similar to T09052 hypotheti 51 436443 AW138211 Hs 128746 ESTs 5 1
408243 Y00787 Hs 624 interieukin 8 51
404819 NM 002688" Homo sapiens peanut (Drosophi 5 1
424914 AA348410 Hs 119065 ESTs 5 1
453331 AI240665 ESTs 5 1
444656 AI277924 Hs 145199 ESTs 5 1
437387 AI198874 Hs 28847 AD026 protein 5 1
421027 AA761198 Hs 55254 ESTs 5 1
410631 AA086469 Hs 47171 ESTs 51
454293 H49739 Hs 134013 ESTs, Moderately similar to HK61_HUMAN H 51
416220 N49776 Hs 170994 hypothedcal protein MGC10946 5 1
419498 AL036591 Hs 20887 hypothedcal protein FU10392 5 1
421040 AA715026 Hs 135280 ESTs 5 1
415170 R44386 Hs 164578 ESTs 51
412590 AL134388 Hs 135033 ESTs, Weakly similar to I38022 hypothed 51
448985 AA324885 Hs 22777 carbonic anhydrase XI 50
433929 AI375499 Hs 27379 ESTs 50
409638 AW450420 Hs 21335 ESTs 50
437916 BE566249 Hs 20999 hypothedcal protein FU23142 50
400533 ENSP00000209376* PRED65 protein (Fragmen 50
430130 AL137311 Hs 234074 Homo sapiens mRNA, cDNA DKFZp761G02121 ( 50
437372 AA323968 Hs 283631 hypothedcal protein DKFZp547G183 50
414737 AI160386 Hs 125087 ESTs 50
422864 AA318323 Hs 12827 gb EST20390 Redna II Homo sapiens cDNA 50
428878 AA436884 Hs 48926 ESTs 50
428841 AI418430 Hs 104935 ESTs 50
428110 AI312485 Hs 138294 ESTs, Moderately similar to Z195.HUMAN Z 50
444170 AW613879 Hs 102408 ESTs 49
448765 R15337 Hs 21958 Homo sapiens mRNA cDNA DKFZp547D086 (fr 49
452106 AI141031 Hs 21342 ESTs 49
417404 NM_007350 Hs 82101 pleckstnn homology-like domain, family 49
414300 AI304870 Hs 188680 ESTs 49
429399 AA452244 Hs 16727 ESTs 49
439726 AW449893 Hs 293707 ESTs, Weakly similar to I38598 zinc fing 49
428873 AI701609 Hs 98908 ESTs 49
451516 AI800515 Hs 12024 ESTs 49
407792 AI077715 Hs 39384 putadve secreted ligand homologous to f 49
416836 D54745 Hs 80247 cholecystokimn 49
447247 AW369351 Hs 287955 Homo sapiens cDNA FLJ 13090 fis, clone NT 49
436805 AA731533 Hs 270751 ESTs 49
423175 W27595 Hs 347310 hypothedcal protein FU14627 49
415402 AA164687 Hs 177576 mannosyl (alpha-1, 3-)-glycoproteιn beta- 49
422263 AA307639 Hs 129908 KIAA0591 protein 48
443715 AI583187 Hs 9700 cyclin EI 48
413248 T64858 Hs 21433 hypothetical protein DKFZp547J036 48
434811 AW971205 Hs 114280 ESTs 48
441287 AW293132 Hs 131373 ESTs 48
428862 NM.000346 Hs 2316 SRY (sex determining region Y)-box 9 (ca 48
413834 BE296896 Hs 224179 ESTs, Weakly similar to 138022 hypothed 48
443740 R56434 Hs 21062 ESTs 48
416871 H98716 gb yx13d08 s1 Soares melanocyte 2NbHM Ho 48
441916 AA993571 Hs 129075 ESTs 48
413530 AA130158 Hs 19977 ESTs, Moderately similar to ALU8.HUMAN A 48
424240 AB023185 Hs 143535 calcium/calmodulin-dependent protein kin 48
414998 NM.002543 Hs 77729 oxidised low density lipoprotein (lecdn 48
448425 AI500359 Hs 346112 ESTs 48
423600 AI633559 Hs 310359 ESTs 48
424687 J05070 Hs 151738 atnx metalloproteinase 9 (geladnase B 48
423869 BE409301 Hs 134012 C1q-related factor 48
425402 AI215881 Hs 24970 ESTs, Weakly similar to B34323 GTP-bindi 47
422809 AK001379 Hs 121028 hypothetical protein FU 10549 47
407808 AA663559 Hs 279789 histone deacetylase 3 47
428748 AW593206 Hs 98785 Ksp37 protein 47
434859 BE255080 Hs 299315 collaps response mediator proteιn-5, C 47
431820 AW410408 Hs 271167 L-pipecolic acid oxidase 47
409100 H98216 Hs 42245 ESTs, Moderately similar to 138022 hypot 47
420133 AA426117 Hs 155543 ESTs 47
420297 AI628272 Hs 88323 ESTs, Weakly similar to ALU1 HUMAN ALU S 47
443462 AI064690 Hs 171176 ESTs 47
424481 R19453 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbac 47
431454 AW975980 Hs 292918 ESTs 47
432682 AI376400 Hs 159588 ESTs 47
434933 R91095 Hs 4276 KIAA1701 protein 47
421247 BE391727 Hs 102910 general transcnpdon factor IIH, polype 47
435538 AB011540 Hs 4930 low density lipoprotein receptor-related 47
441703 AW390054 Hs 192843 leucine zipper protein FKSG14 47
418661 NM 001949 Hs 1189 E2F transcnpdon factor 3 47
412266 N59006 Hs 26133 ESTs 47
417675 AI808607 Hs 3781 similar to unne leucine-nch repeat pr 46
422564 AI148006 Hs 222120 ESTs 46
427250 R35941 Hs 25418 ESTs 46
427695 R88483 Hs 172862 ESTs 46
434269 AK001991 Hs 3781 similar to muπne leucine-nch repeat pr 46 407603 AW955705 Hs 62604 Homo sapiens clone IMAGE 4299322, mRNA, 46
427687 AW003867 Hs 1570 histamine receptor H1 46
427194 AA399018 Hs 250835 ESTs 46
440286 U29589 Hs 7138 chodnergic receptor, muscaπnic 3 46
427099 AB032953 Hs 173560 odd Oz/ten-m homolog 2 (Drosophila, mous 46
458760 AI498631 Hs 111334 fe dn, light polypeptide 46
433675 AW977653 Hs 75319 πbonucleodde reductase M2 polypeptide 46
429170 NM 001394 Hs 2359 dual specificity phosphatase 4 46
427712 AI368024 Hs 283696 ESTs 46
437834 AA769294 Hs 283854 gb nz36g03 s1 NCI.CGAP.GCB1 Homo sapiens 46
408947 AL080093 Hs 49117 Homo sapiens mRNA, cDNA DKFZp564N1662 (f 46
424458 M29273 Hs 1780 myelin associated glycoprotein 46
450568 AL050078 Hs 25159 Homo sapiens cDNA FU10784 fis, clone NT 46
424635 AA420687 Hs 115455 Homo sapiens cDNA FU 14259 fis, clone PL 46
440491 R35252 Hs 130558 ESTs, Weakly similar to 2109260A B cell 46
428409 AW117207 Hs 98523 ESTs 45
423476 AL035633 Human DNA sequence from clone RP5-1046G1 45
421977 W94197 Hs 110165 nbosomal protein L26 homolog 45
440105 AA694010 Hs 6932 Homo sapiens clone 23809 mRNA sequence 45
422411 AW749443 Hs 22511 ESTs 45
443361 AI792628 Hs 133273 ESTs 45
453857 AL080235 Hs 35861 DKFZP586E1621 protein 45
408432 AW195262 gb xn67b05x1 NCI CGAP CML1 Homo sapiens 45
444127 N63620 Hs 13281 ESTs 45
417435 NM 005181 Hs 82129 carbonic anhydrase III, muscle specific 45
422661 NM 014700 Hs 119004 KIAA0665 gene product 45
440684 AI253123 Hs 127356 ESTs, Highly similar to S21424 nesdn [H 45
407385 AA610150 Hs 272072 ESTs, Weakly similar to I38022 hypothed 45
425256 BE297611 Hs 155392 collapsin response mediator protein 1 45
441364 AW450466 Hs 126830 ESTs, Weakly similar to YD38_YEAST HYPOT 45
430471 AF064845 Hs 241523 hypothedcal protein FLJ10142 45
412043 BE156622 Hs 333371 Homo sapiens clone TA40 untranslated mRN 45
426503 AA380153 gb EST93093 Skin tumor I Homo sapiens cD 45
418771 AA807881 Hs 25329 ESTs 44
414706 AW340125 Hs 76989 KIAA0097 gene product 44
424800 AL035588 Hs 153203 MyoD family inhibitor 44
441217 AI922183 Hs 213246 ESTs 44
422421 AA325138 Hs 235873 hypothedcal protein FU22672 44
446619 AU076643 Hs 313 secreted phosphoprotein 1 (osteopontm, 44
444153 AKO01610 Hs 10414 hypothedcal protein FU10748 44
435542 AA687376 ESTs 44
443912 R37257 Hs 184780 ESTs 44
414922 D00723 Hs 77631 glycine cleavage system protein H (ammo 44
432527 AW975028 Hs 102754 ESTs 44
410082 AA081594 Hs 158311 Musashi (Drosophila) homolog 1 44
446936 H10207 Hs 47314 ESTs 44
425212 AW962253 Hs 171618 ESTs 44
426925 NM 001196 Hs 315689 Homo sapiens cDNA FU22373 fis, clone H 44
427221 L15409 Hs 174007 von Hippel-ϋndau syndrome 44
439274 AF086092 Hs 48372 ESTs 44
412799 AI267606 gb aq91h03 x1 Stanley Frontal SB pool 1 44
430676 AF084866 gb Homo sapiens envelope protein RIC-3 ( 44
405348 C7001664 gι|12698061|dbj|BAB21849 1| (AB 44
419412 AW161058 Hs 90297 synuclein, beta 43
447397 BE247676 Hs 18442 E-1 enzyme 43
409125 R17268 Hs 343567 axonal transport of synapdc vesicles 43
433323 AA805132 Hs 159142 ESTs 43
450530 NM 006668 Hs 25121 cytochrome P450, subfamily 46 (cholester 43
428227 AA321649 Hs 2248 small inducible cytokine subfamily B (Cy 43
408622 AA056060 Hs 202577 Homo sapiens cDNA FU12166 fis, clone MA 43
433610 AA806822 Hs 112547 ESTs 43
429281 AA830856 Hs 29808 Homo sapiens cDNA FU21122 fis, clone C 43
451320 AW118072 diacylglycerol kinase, zeta (104kD) 43
430979 AI479755 Hs 129010 ESTs 43
452092 BE245374 Hs 27842 hypothetical protein FU11210 43
438456 AA913381 Hs 20594 ESTs 43
433236 NM 004296 Hs 3221 regulator of G-protem signalling 6 43
445133 AW157646 Hs 198689 ESTs 43
412125 Y17114 Hs 73393 eyes absent (Drosophila) homolog 4 42
432882 NM 013257 Hs 279696 serum/glucocorticoid regulated kinase-li 42
407846 AA426202 Hs 40403 Cbp/p300-ιnteracdng transacdvator, wit 42
417918 AA209205 Hs 163754 hypothedcal protein FU12606 42
424489 T48851 Hs 274470 D-siglec precursor 42
453682 T79703 gb yd71e08 r1 Soares fetal liver spleen 42
445568 H00918 Hs 268744 KIAA1796 protein 42
448526 AB028946 Hs 21361 KIAA1023 protein 42
426457 AW894667 Hs 169965 chimeπn (chimaeπn) 1 42
415796 R87548 Hs 78854 ATPase, Na? transporting, beta 2 polypep 42
438875 AA827640 Hs 189059 ESTs 42
428001 H97428 Hs 219907 ESTs, Moderately similar to Transforming 42
410361 BE391804 Hs 62661 guanylate binding protein 1, iπterferon- 4 2
445921 AW015211 Hs 146181 ESTs 42
412190 R16180 Hs 274461 ESTs 42 445666 R59960 Hs 282386 ESTs 42
439538 AA837323 Hs 56407 ESTs 42
437814 AI088192 Hs 135474 ESTs, Weakly similar to DDX9_HUMAN ATP-D 42
410264 AK001853 Hs 61508 Homo sapiens cDNA FLJ10991 fis, clone PL 42
409091 AW970386 Hs 269423 ESTs 42
459527 AW977556 Hs 291735 ESTs, Weakly similar to I78885 seπneΛh 42
426271 AF026547 Hs 169047 chondroidn sulfate proteoglycan 3 (neur 42
432731 R311 8 Hs 287820 fibronecdn 1 42
423135 N67655 Hs 26411 ESTs 42
446131 NM 000929 Hs 290 phospholipase A2, group V 42
424736 AF230877 Hs 152701 microtubule-interacdng protein that ass 42
408298 AI745325 Hs 271923 Homo sapiens cDNA FU22785 fis, clone K 42
452234 AW084176 Hs 223296 ESTs, Weakly similar to 138022 hypothed 42
451468 AW503398 Hs 293663 ESTs, Moderately similar to 138022 hypot 42
429421 AL031658 Human DNA sequence from clone RP1-310O13 42
422374 AW732869 Hs 1519 protein kinase cAMP-depeπdent, regulate 41
402145 Target Exon 4 1
440483 AI200836 Hs 150386 ESTs 4 1
425018 BE245277 Hs 154196 E4F transcnpdon factor 1 41
448048 BE281291 Hs 170408 ESTs, Moderately similar to A47582 B-cel 4 1
445868 BE169357 Hs 207428 ESTs 41
431725 X65724 Hs 2839 Nome disease (pseudoglioma) 41
435575 AF213457 Hs 44234 tnggeπng receptor expressed on myeloid 41
424726 AK001007 Hs 138760 Homo sapiens cDNA FU10145 fis, clone HE 41
450325 AI935962 Hs 26289 ESTs 4 1
450639 AI703186 Hs 277174 ESTs 4 1
445102 AW204610 Hs 22270 ESTs 41
416547 H62914 Hs 268946 ESTs, Weakly similar to PC4259 femdn 4 1
430387 AW372884 Hs 240770 nuclear cap binding protein subunit 2, 2 41
408296 AL117452 Hs 44155 DKFZP586G1517 protein 4 1
439519 AA837118 Hs 118366 ESTs 41
442326 H92962 Hs 124813 hypothedcal protein MGC14817 41
404150 Target Exon 41
420805 L10333 Hs 99947 redculon 1 41
429125 AA446854 Hs 271004 ESTs, Weakly similar to 138022 hypothed 4 1
427302 AA400540 Hs 135282 Homo sapiens cDNA FU11554 fis, clone HE 41
444534 AW271626 Hs 42294 ESTs 4 1
437414 AW894071 Hs 48448 hypothedcal protein DKFZp547C176 41
418512 AW498974 diacylglycerol kinase, zeta (104kD) 41
414217 AI309298 Hs 279898 Homo sapiens cDNA FU23165 fis, clone L 41
449328 AI962493 Hs 345303 ESTs 41
432683 AW995441 Hs 10475 ESTs 4 1
435312 AJ243396 Hs 4865 voltage-gated sodium channel beta-3 subu 4 1
429163 AA884766 gb am20a10s1 Soares NFL T GBC.S1 Homos 4 1
453096 AW294631 Hs 11325 ESTs 4 1
414683 S78296 Hs 76888 hypothedcal protein MGC12702 40
433523 H29882 ESTs 40
422170 AI791949 Hs 112432 anti-Mulleπan hormone 40
424120 T80579 Hs 290270 ESTs 40
448548 R13209 Hs 21413 solute earner family 12, (potassium-chl 40
433009 AA761668 gb nz24c08 s1 NCI.CGAP.GCB1 Homo sapiens 40
434834 AF156774 Hs 324020 1-acylglycerol-3-phosphate O-acyltransfe 40
439099 AB037800 Hs6462 protein kinase C and casein kinase subst 40
444001 AI095087 Hs 152299 ESTs, Moderately similar to S65657 alpha 40
413554 AA319146 Hs 75426 secretogranin II (chromogranin C) 40
423279 AW959861 Hs 290943 ESTs 40
457211 AW972565 Hs 32399 ESTs, Weakly similar to S51797 vasodilat 40
450581 AF081513 Hs 25195 TGF-beta4 40
435854 AJ278120 Hs 4996 putadve ankyπn-repeat containing prote 40
433615 AA732982 Hs 269607 ESTs, Weakly similar to ALU1_HUMAN ALU S 40
424001 W67883 Hs 137476 paternally expressed 10 40
432058 AW665996 Hs 130729 ESTs, Weakly similar to ALU1 HUMAN ALU S 40
423713 AW754182 gb RC2-CT0321-131199-011-C01 CT0321 Homo 40
419629 AB020695 Hs 91662 KIAA0888 protein 40
439108 AW163034 Hs 6467 synaptogyπn 3 40
440866 AI703103 Hs 271360 hypothedcal protein MGC16275 40
422887 AI751848 Hs 49215 ESTs 40
405331 NM_024560Ηomo sapiens hypothedcal prot 40
457005 AJ007421 Hs 172597 sal (Drosophιla)-lιke 3 40
437948 AA772920 Hs 303527 ESTs 40
440471 AA886146 Hs 307944 ESTs 40
432149 AW614326 Hs 133483 ESTs, Weakly similar to T34549 probable 40
449655 AI021987 Hs 59970 ESTs 40
448299 AA497044 Hs 20887 hypothedcal protein FU10392 40
435743 T66861 Hs 12962 ESTs 40
412659 AW753865 Hs 74376 olfactomedin related ER localized protei 40
430694 AA810624 Hs 30936 ESTs, Weakly similar to H2BH HUMAN HISTO 39
437807 AI017875 Hs 136829 ESTs 39
440085 BE270761 Hs 23158 ESTs 39
449722 BE280074 Hs 23960 cycdn B1 39
445523 Z30118 Hs 293788 ESTs, Moderately similar to unnamed prot 39
420948 AB016898 Hs 100469 myeloid/lymphoid or mixed-lineage leukem 39
407198 H91679 gb yv04a07 s1 Soares fetal liver spleen 39 447519 U46258 Hs 339665 ESTs 39
429038 AL023513 Hs 194766 seizure related gene 6 (mouse)-lιke 39
414761 AU077228 Hs 77256 enhancer of zeste (Drosophila) homolog 2 39
404584 Target Exon 39
449670 F07693 Hs 85603 Homo sapiens mRNA, cDNA DKFZp434K2172 (f 39
414117 W88559 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbac 39
433290 R20077 Hs 302185 Homo sapiens clone 23618 mRNA sequence 39
441707 R42637 Hs 21963 hypothedcal protein DKFZp761B0514 39
431789 H19500 Hs 269222 mitogen-acdvated protein kinase 4 39
434149 Z43829 Hs 244624 hypothedcal protein MGC5469 39
446896 T15767 Hs 22452 Homo sapiens mRNA for KIAA1737 protein, 39
411555 AF113537 Hs 70669 HMP19 protein 39
426646 AA382787 Hs 122713 ESTs 39
450297 AW901347 Hs 38592 hypothedcal protein FU23342 39
429228 AI553633 Hs 326447 ESTs 39
451433 AA021140 Hs 269265 ESTs, Weakly similar to A46010 X-lmked 39
447937 AL109716 Hs 20034 Homo sapiens mRNA full length insert cDN 39
436734 AI937612 Hs 273758 hypothedcal protein FU23112 39
417576 AA339449 Hs 82285 phosphonbosylglycinamide formyltransfer 39
417632 R20855 Hs 5422 glycoprotein M6B 39
414245 BE148072 Hs 75850 WAS protein family, member 1 39
418203 X54942 Hs 83758 CDC28 protein kinase 2 39
453438 AI469935 Hs 22792 ESTs 39
408449 NM 004408 Hs 166161 dynamin 1 38
411048 AK001742 Hs 67991 hypothetical protein DKFZp434G0522 38
405819 NM_002578 Homo sapiens p21 (CDKN1 A)-acb 38
445255 NM 014841 Hs 12477 synaptosomal-associated protein, 91 kDa 38
432715 AA247152 Hs 200483 ESTs, Weakly similar to KIAA1074 protein 38
457292 AI921270 Hs 281462 hypothedcal protein FU14251 38
432593 AW301003 Hs 51483 ESTs, Weakly similar to hypothedcal pro 38
413589 AW452631 Hs 313803 ESTs, Highly similar to AF157833 1 noncl 38
426847 S78723 Hs 298623 5-hydroxytryptamιne (serotonin) receptor 38
410768 AF038185 Hs 66187 Homo sapiens clone 23700 mRNA sequence 38
417791 AW965339 Hs 111471 ESTs 38
454120 AB032990 Hs 40719 hypothetical protein KIAA1164 38
425154 NM 001851 Hs 154850 collagen, type I alpha 1 38
449145 AI632122 Hs 198408 ESTs 38
446997 AA383439 Hs 16758 Spιr-1 protein 38
407304 AA565832 Hs 271649 gb n|32b03s1 NCI CGAP AA1 Homo sapiens 38
437269 AA334384 Hs 149420 ESTs 38
443539 AI076182 Hs 134074 ESTs, Moderately similar to ALU6.HUMAN A 38
426855 AL117427 Hs 172778 Homo sapiens mRNA, cDNA DKFZp566P013 (fr 38
418821 AA436002 Hs 183161 ESTs 38
408875 NM 015434 Hs 48604 DKFZP434B168 protein 38
422175 N79885 Hs 6382 ESTs, Highly similar to T00391 hypothed 38
432488 AA551010 Hs 216640 ESTs 38
450582 AI339732 G-πch RNA sequence binding factor 1 38
426380 AI291267 Hs 149990 ESTs 38
451407 AA131376 Hs 343809 fibroblast growth factor 12B 38
451778 AI826131 Hs 62954 ESTs, Weakly similar to zinc finger prot 38
425652 AB021742 Hs 322431 neurogenic differentiation 2 38
412820 BE001236 gb CM3-BN0075-240200-101-d11 BN0075 Homo 38
412193 AI684467 Hs 144057 ESTs 38
431117 AF003522 Hs 250500 delta (DrosophilaHike 1 38
433042 AW193534 Hs 281895 Homo sapiens cDNA FU 11660 fis, clone HE 38
437756 AA767537 Hs 197096 ESTs 38
451367 AA923729 Hs 26322 cell cycle related kinase 38
425390 AI092634 Hs 156114 protein tyrosine phosphatase, non-recept 38
445292 AV653264 Hs 13982 Homo sapiens cDNA FU14666 fis, clone NT 38
425843 BE313280 Hs 159627 death associated protein 3 38
443301 AI733614 Hs 220587 ESTs, Moderately similar to ALU5 HUMAN A 37
440210 AW674562 Hs 125296 ESTs 37
430287 AW182459 Hs 125759 ESTs, Weakly similar to LEU5.HUMAN LEUKE 37
437252 AI433833 Hs 164159 ESTs, Weakly similar to ALU1.HUMAN ALU S 37
409327 L41162 Hs 53563 collagen, type IX, alpha 3 37
429084 AJ001443 Hs 195614 splicing factor 3b, subunit 3, 130kD 37
457183 H91882 Hs 118569 Dvl-biπding protein IDAX (inhibition of 37
403696 C4001100* gι|5852342|gb|AAD54015 1| (AF0 37
408670 AF160967 Hs 46784 potassium large conductance calcium-acd 37
416677 T83470 Hs 334840 ESTs, Moderately similar to I78885 senn 37
422253 W81526 Hs 118329 ESTs, Moderately similar to GAD.HUMAN GA 37
450154 R15891 Hs 281587 Human (clone CTG-A4) mRNA sequence 37
408453 AI369838 Hs 45127 chondroidn sulfate proteoglycan 5 (neur 37
440553 AA889416 Hs 344043 Homo sapiens cDNA FU14459 fis, clone HE 37
428536 AI143139 Hs 2288 vis in-like 1 37
426413 AA377823 gb EST90805 Synovial sarcoma Homo sapien 37
409172 Z99399 Hs 122593 ESTs 37
441627 AA947552 Hs 58086 branched chain aminotransferase 1, cytos 37
418216 AA662240 Hs 283099 AF15q14 protein 37
408790 AW580227 Hs 47860 neurotrophic tyrosine kinase, receptor, 37
437449 AL390153 Hs 208339 Homo sapiens mRNA, cDNA DKFZp?62G113 (fr 37
436035 AA703679 Hs 106999 ESTs, Weakly similar to SYT5_HUMAN SYNAP 37
451697 AW449774 Hs 296380 POM (POM121 rat homolog) and ZP3 fusion 37 436961 AW375974 Hs 156704 ESTs 37
409953 AA332277 Hs 57691 cadheπn 18, type 2 37
435832 AA425688 Hs 41641 Bruno (Drosophila) -like 4 RNA binding 37
424343 AW956360 Hs 4748 adenylate cyclase acdvadng polypepdde 36
437470 AL390147 Hs 134742 hypothetical protein DKFZp547D065 36
440168 AA868507 Hs 126141 ESTs 36
427624 AA406245 Hs 24895 ESTs 36
418293 AI224483 Hs 16063 hypothetical protein FU21877 36
445888 AF070564 Hs 13415 Homo sapiens clone 24571 mRNA sequence 36
458912 AI911066 ESTs 36
419390 AI701162 Hs 90207 hypothedcal protein MGC11138 36
449256 AA059050 Hs 59847 ESTs 36
425010 T16837 Hs 4241 ESTs 36
412754 AW160375 Hs 74565 amyloid beta (A4) precursor-like protein 36
400777 NM_007325" Homo sapiens glutamate recept 36
438831 BE263273 Hs 6439 synapsin II 36
419235 AW470411 Hs 288433 neurotπmin 36
424947 R77952 ESTs, Weakly similar to alternatively sp 36
407624 AW157431 Hs 248941 ESTs 36
440351 AF030933 Hs 7179 RAD1 (S pombe) homolog 36
440404 AI015881 Hs 324527 mitochondnal πbosomal protein S5 36
439267 AA287747 Hs 173012 ESTs, Weakly similar to A46010 X-lmked 36
424340 AA339036 Hs 7033 ESTs 36
423178 AI033140 Hs 124983 Homo sapiens mRNA, cDNA DKFZp564C142 (fr 36
418064 BE387287 Hs 83384 S100 calcium-binding protein, beta (neur 36
428483 AI908539 Hs 184592 KIAA0344 gene product 36
453875 AW001783 Hs 232711 ESTs 36
430183 BE010038 gb PM3-BN0176-100400-001-g04 BN0176 Homo 36
431552 AI815863 Hs 259873 axonal transport of syπapdc vesicles 36
424278 AK000723 Hs 144517 hypothedcal protein FLJ20716 36
434131 AI858275 Hs 143659 ESTs 36
435923 BE301930 Hs 5010 Homo sapiens clone 24672 mRNA sequence 36
415709 AA649850 Hs 278558 ESTs 36
437640 AA764893 Hs 272155 ESTs, Weakly similar to I38022 hypothed 36
419586 AI088485 Hs 144759 ESTs, Weakly similar to I38022 hypothed 36
414040 N58513 Hs 32171 ESTs 36
427315 AA179949 Hs 175563 Homo sapiens mRNA, cDNA DKFZp564N0763 (f 36
410711 AB002316 Hs 65746 KIAA0318 protein 36
445953 AI612775 Hs 145710 ESTs 36
444794 AI419991 Hs 145225 ESTs 36
411968 AI207410 Hs 69280 Homo sapiens, clone IMAGE 3636299, mRNA, 36
428180 AM 29767 Hs 182874 guanine nucleotide binding protein (G pr 36
415283 R40504 Hs 21245 ESTs 36
433160 AW207002 Hs 134342 TASP for tesds-specific adπamycin sens 35
410386 W26187 Hs 3327 Homo sapiens cDNA FU22219 fis, clone H 35
430818 AI311928 Hs 348156 gb qo89h04 x1 NCI_CGAP_Kιd5 Homo sapiens 35
433932 AW954599 Hs 169330 neuronal protein 35
420578 AA813546 Hs 99034 GTP-binding protein Rho7 35
456723 Z43902 Hs 4748 adenylate cyclase acdvadng polypepdde 35
416340 N31772 Hs 79226 fasciculation and elongation protein zet 35
451455 AI937227 Hs 8821 hepcidin antimicrobial pepdde 35
412719 AW016610 Hs 816 ESTs 35
435910 AI084152 Hs 21782 ESTs, Weakly similar to ALU7.HUMAN ALU S 35
439340 AB032436 Hs 6535 brain-specific Na-dependent inorganic ph 35
458072 AI890347 Hs 271923 Homo sapiens cDNA FU22785 fis, clone K 35
439710 AF086543 gb Homo sapiens full length insert cDNA 35
453896 AW293483 Hs 255205 KIAA1853 protein 35
407253 AA411175 Hs 141939 ESTs, Moderately similar to S65657 alpha 35
449969 AW295142 Hs 180187 Homo sapiens cDNA FU14337 fis, clone PL 35
439231 AW581935 Hs 141480 Homo sapiens mRNA, cDNA DKFZp434N079 (fr 35
424332 AA338919 Hs 101615 ESTs 35
456497 AW967956 Hs 123648 ESTs, Weakly similar to AF108460 1 ubinu 35
442264 AI278777 Hs 263455 ESTs, Weakly similar to ALU1_HUMAN ALU S 35
404295 Target Exon 35
427209 H06509 Hs 92423 KIAA1566 protein 35
439627 BE621702 Hs 29076 hypothedcal protein FU21841 35
427513 AI476318 Hs 192480 ESTs 35
458435 AI418718 Hs 144121 ESTs, Weakly similar to T46916 hypotheti 35
435545 AA687415 Hs 28107 ESTs 35
413199 M62843 Hs 75236 ELAV (embryonic lethal, abnormal vision, 35
441607 NM 005010 Hs 7912 neuronal cell adhesion molecule 35
452449 AW068658 Hs 20943 ESTs 35
443257 AI334040 Hs 11614 HSPC065 protein 35
423641 AL137256 Hs 130489 ATPase, ammophospholipid transporter-li 35
427581 NM 014788 Hs 179703 KIAA0129 gene product 35
424090 X99699 Hs 139262 XIAP associated factor- 1 35
422906 U80773 Hs 121580 Human EST clone 42944 manner transposon 35
429698 AI685086 Hs 26339 ESTs, Weakly similar to S21348 probable 35
439920 H05430 Hs 288433 neurotnmm 35
436899 AA764852 Hs 291567 ESTs 35
414178 AW957372 Hs 46791 ESTs, Weakly similar to I38022 hypotheti 35
418365 AW01 345 Hs 161690 ESTs 34
414598 AI094221 Hs 135150 lung type-l cell membrane-associated gly 34 452571 W31518 Hs 34665 ESTs 34
443633 AL031290 Hs 9654 similar to pregnancy-associated plasma p 34
408955 BE315170 Hs 8087 Target CAT 34
443206 AB011420 Hs 9075 seπne/threoπme kinase 17a (apoptosis-i 34
419617 AL008583 Hs 91622 neuronal pentraxin receptor 34
454171 AW854832 gb QV2-CT0261-201099-011-f05 CT0261 Homo 34
426529 AF090100 Hs 170241 Homo sapiens clone IMAGE 23915 34
440652 AI216751 Hs 143977 ESTs 34
450813 AI739625 Hs 203376 ESTs 34
429323 NM.001649 Hs 2391 apical protein, Xenopus laevis-like 34
439774 AL360257 Hs 213493 Homo sapiens mRNA full length insert cDN 34
409892 AW956113 Hs 7149 gb EST368183 MAGE resequences, MAGD Homo 34
439963 AW247529 Hs 6793 platelet-activating factor acetylhydrola 34
416658 U03272 Hs 79432 fibπllin 2 (congenital contractual ara 34
453740 AL120295 Hs 311809 ESTs, Moderately similar to PC4259 fem 34
435256 AF193766 Hs 13872 cytokine-like protein C17 34
453305 R39224 Hs 267997 EHM2 gene 34
425287 R88249 Hs 155524 peanut (Drosophιla)-lιke 2 34
417663 R07483 Hs 180461 ESTs 34
448533 AL119710 Hs 21365 nucleosome assembly protein 1-lιke 3 34
441834 AL138034 Hs 7979 KIAA0736 gene product 34
457876 AI821940 ESTs, Moderately similar to ALU8_HUMAN A 34
407842 BE410100 Hs 40368 adaptor-related protein complex 1, sig a 34
422676 D28481 Hs 1570 histamine receptor H1 34
408926 AF217525 Hs 49002 Down syndrome cell adhesion molecule 34
430762 AI343652 Hs 105667 ESTs 34
430890 X54232 Hs 2699 glypican 1 34
445078 AI869975 Hs 4775 junctophilin 3 34
423257 AW161039 Hs 125878 synapsin III 34
417402 BE503227 Hs 134759 ESTs 34
410011 AB020641 Hs 57856 PFTAIRE protein kinase 1 34
404541 NM_030795 Homo sapiens stathmm-like 4 ( 34
436291 BE568452 Hs 344037 protein regulator of cytokinesis 1 34
443672 AA323362 Hs 9667 butyrobetaine (gamma), 2-oxoglutarate di 34
432140 AK000404 Hs 272688 hypothetical protein FLJ20397 34
451061 AW291487 Hs 213659 ESTs, Weakly similar to KIAA1357 protein 34
425782 U66468 Hs 159525 cell growth regulatoiy with EF-hand doma 34
420692 AW976345 gb EST388454 MAGE resequences, MAGN Homo 34
410507 AA355288 Hs 76064 fransitional epithelia response protein 34
412436 AA665089 gb nu76d01 s1 NCI_CGAP_Alv1 Homo sapiens 34
448112 AW245919 Hs 34969 hypothedcal protein DKFZp566N034 34
429269 AA449013 Hs 99203 ESTs 34
408037 AW271720 Hs 42233 hypothedcal protem FU 10300 33
418858 AW961605 Hs 21145 hypothedcal protein RG083M052 33
420050 AL118615 Hs 94653 neurochoπdπn 33
436277 R88520 Hs 120917 ESTs 33
430412 AW341754 Hs 189305 ESTs 33
408554 AA836381 Hs 315111 nuclear receptor co-repressor/HDAC3 comp 33
432663 AI984317 Hs 122589 ESTs 33
449919 AI674685 Hs 200141 ESTs 33
438509 R45367 Hs 101191 ESTs 33
429037 X81895 Hs 194765 H sapiens GENX-5624 mRNA 3' UTR 33
445537 AJ245671 Hs 12844 EGF-like-domain, muldple 6 33
425537 AB007913 Hs 158291 KIAA0444 protein 33
408369 R38438 Hs 182575 solute earner family 15 (H"? transport 33
449686 AW072813 Hs 270868 ESTs, Moderately similar to ALU4.HUMAN A 33
417333 AL157545 Hs 173179 bromodomam and PHD finger containing, 3 33
410592 R94088 Hs 43569 ESTs 33
439444 AI277652 Hs 54578 ESTs, Weakly similar to 138022 hypothed 33
435375 AI733610 Hs 187832 ESTs 33
409746 NM 004794 Hs 56294 RAB33A, member RAS oncogene family 33
425588 F07396 Hs 46627 ESTs 33
412155 R38167 Hs 12449 Homo sapiens transmembrane protein HTMP1 33
425242 D13635 Hs 155287 KIAA0010 gene product 33
417280 AW173116 Hs 250103 ESTs 33
423748 AI149048 Hs 30211 hypothetical protein FLJ22313 33
452856 AF034799 Hs 30881 protein tyrosine phosphatase, receptor t 33
419103 Z40229 Hs 96423 hypothedcal protein FU23033 33
435718 R06569 Hs 269534 ESTs 33
449249 T52285 Hs 193115 Homo sapiens mRNA for KIAA1764 protein , 33
423770 AW976766 Hs 132776 Homo sapiens cDNA FLJ10077 fis, clone HE 33
409557 BE182896 Hs 211193 ESTs 33
439285 AL133916 hypothetical protein FU20093 33
421183 AL135740 Hs 102447 TSC-22-lιke 33
433894 AI907682 Hs 243293 ESTs 33
445225 AI216555 Hs 202398 ESTs 33
411379 AI816344 Hs 12554 ESTs, Weakly similar to NPL4.HUMAN NUCLE 33
436207 AA334774 Hs 12845 hypothedcal protein MGC13159 33
436870 AW204219 Hs 155560 calnexin 33
441791 AW372449 Hs 61271 hypothedcal protein FLJ21159 33
408547 AA574291 Hs 57837 ESTs 33
420982 AW576160 Hs 100729 KIAA0692 protein 33
451625 R56793 Hs 106576 alaπine-glyoxylate aminotransferase 2-lι 33 418932 L34059 Hs 89484 cadhenn 4, type 1, R-cadheπn (rednal) 33
453496 AA442103 Hs 33084 solute earner family 2 (facilitated glu 33
423169 BE047009 Hs 21837 ESTs, Weakly similar to KIAA0927 protein 33
418049 AA211467 Hs 190488 Homo sapiens, Similar to nuclear localiz 33
441243 AI767056 Hs 193002 ESTs 33
444427 H25094 Hs 293663 ESTs, Moderately similar to I38022 hypot 33
449115 AW959952 Hs 37528 ESTs, Weakly similar to AF090944 1 PRO06 33
446416 AV658299 Hs 163959 ESTs 33
437762 T78028 Hs 154679 synaptotagmin I 33
450336 AA046814 Hs 288928 Homo sapiens cDNA FU23296 fis, clone H 33
433842 AI652156 Hs 26346 ESTs 33
444124 R43097 Hs 6818 ESTs 33
423858 AL137326 Hs 133483 Homo sapiens mRNA, cDNA OKFZp434B0650 (f 33
454792 AW820794 Hs 252406 hypothetical protein FU 12296 similar to 33
412775 AA709046 Hs 27552 Homo sapiens mRNA, cDNA DKFZp586N2424 (f 33
429609 AF002246 Hs 210863 cell adhesion molecule with homology to 32
413951 AW051200 Hs 75640 natπuredc peptide precursor A 32
433325 AW206986 Hs 143905 ESTs 32
449092 U91641 Hs 22985 alpha2,8-sιalyltransferase 32
422390 AW450893 Hs 121830 ESTs, Weakly similar to T42682 hypothed 32
424899 AL119387 Hs 119062 ESTs 32
454253 AV660717 Hs 47144 DKFZP586N0819 protein 32
410126 BE169274 KIAA0036 gene product 32
456508 AA502764 Hs 123469 ESTs, Weakly similar to AF208855 1 BM-01 32
405303 Target Exon 32
420871 AA702972 Hs 65300 ESTs 32
442432 BE093589 Hs 38178 hypothedcal protein FU23468 32
425769 U72513 Hs 159486 Human RPL13-2 pseudogene mRNA, complete 32
442320 AI287817 Hs 129636 ESTs 32
407378 AA299264 Hs 57776 ESTs, Moderately similar to 138022 hypot 32
439764 T26535 Hs 22744 hypothedcal protein MGC13105 32
410425 BE278367 Hs 63510 KIAA0141 gene product 32
422156 N34524 gb yy56d10 s1 Soares.multiple.sclerosis. 32
451489 NM 005503 Hs 26468 amyloid beta (A4) precursor protein-bind 32
457358 AI479755 Hs 129010 ESTs 32
407721 Y12735 Hs 38018 dual-specificity tyrosme-(Y)-phosphoryl 32
452372 AI885742 Hs 228474 ESTs 32
459660 M79082 ESTs 32
437085 AA743935 Hs 202329 ESTs 32
419852 AW503756 Hs 286184 hypothetical protein dJ551D25 32
440080 AW051597 Hs 143707 ESTs 32
449714 AB033015 Hs 23941 KIAA1189 protein 32
450407 NM 000810 Hs 24969 gamma-aminobutync acid (GABA) A recepto 32
423165 AI937547 Hs 124915 hypothedcal protein MGC2601 32
449961 AW265634 Hs 133100 ESTs 32
454036 AA374756 Hs 93560 Homo sapiens mRNA for KIAA1771 protein, 32
419865 NM 007020 Hs 93502 U1-snRNP binding protein homolog (70kD) 32
423420 AI571364 Hs 128382 Homo sapiens mRNA, cDNA DKFZp761l1224 (f 32
420352 BE258835 gb 601117374F1 NIH.MGC.16 Homo sapiens c 32
424641 AB001106 Hs 151413 glia maturadon factor, beta 32
453544 AA831785 Hs 171914 Homo sapiens cDNA FLJ14209 fis, clone NT 32
447877 AI435184 Hs 164252 ESTs 32
419683 AA248897 Hs 48784 ESTs 32
451026 AA013218 Hs 157492 cer-d4 (mouse) homolog 32
422709 AA315331 Hs 153485 ESTs 32
432809 AA565509 Hs 131703 ESTs 32
446593 W79572 Hs 13277 hypothedcal protein FU22054 32
457728 AW974811 gb EST386916 MAGE resequences, MAGN Homo 32
403790 NM.0O1334* Homo sapiens cathepsin O (CTS 32
445413 AA151342 Hs 12677 CGI-147 protein 32
438703 AI803373 Hs 31599 ESTs 31
434577 R37316 Hs 179769 Homo sapiens cDNA FLJ22487 fis, clone H 31
422772 AL119585 Hs 120228 KIAA0749 protein 31
433434 AA588429 gb no22b03 s1 NCI CGAP P.22 Homo sapiens 31
427961 AW293165 Hs 143134 ESTs 3 1
414430 AI346201 Hs 76118 ubiquitin carboxyl-termmal esterase L1 31
420552 AK000492 Hs 98806 hypothedcal protein 31
456209 W60633 Hs 297792 ESTs 31
418819 AA228776 Hs 191721 ESTs 31
438944 AA302517 Hs 92732 KIAA1444 protein 3 1
439086 AF085947 gb Homo sapiens full length insert cDNA 31
451734 NM 006176 Hs 26944 πeurogranin (protein kinase C substrate 3 1
415257 F03016 Hs 27513 ESTs 31
442789 AW904361 Hs 131191 ESTs, Weakly similar to ALU7.HUMAN ALU S 31
432675 AI791855 Hs 105884 ESTs 3 1
426600 NM 003378 Hs 171014 VGF nerve growth factor inducible 31
435092 AL137310 Hs 4749 Homo sapiens mRNA cDNA DKFZp761E13121 ( 3 1
439039 AI656707 Hs 48713 ESTs 31
450358 AB010O98 Hs 24907 coroniπ, acdn-binding protein, 2B 31
400850 Target Exon 3 1
417636 R08916 Hs 191212 ESTs 31
425790 AW136286 Hs 288446 ESTs 3 1
415314 N88802 Hs 5422 glycoprotein M68 31 436456 AW292677 Hs 248122 G protein-coupled receptor 24 31
408601 U47928 Hs 86122 protein A 31
420886 AA805453 ESTs, Weakly similar to T29012 hypothed 31
437162 AW005505 Hs 5464 thyroid hormone receptor coacdvadng pr 31
445704 AI493742 Hs 167700 ESTs, Moderately similar to I38022 hypot 31
440700 AW952281 Hs 296184 guanine nucleotide binding protein (G pr 3 1
414747 U30872 Hs 77204 centromere protein F (350/400kD, mitosin 31
431553 X78075 Hs 2799 cartilage linking protein 1 3 1
405605 C2001342 gι|127814|sp|P26434|NAH4.RAT SO 3 1
431467 N71831 Hs 256398 Homo sapiens mRNA cDNA DKFZp434E0528 (f 31
457561 AA331517 Hs 286055 chimeπn (chimaeπn) 2 31
412507 L36645 Hs 73964 EphA4 3 1
413448 AL134467 Hs 25307 Homo sapiens clone 24812 mRNA sequence 31
444168 AW379879 gb RC1-HT0256-081199-011-f01 HT0256 Homo 31
400090 Eos Control 3 1
433642 BE466341 Hs 189746 ESTs, Weakly similar to 138022 hypothed 3 1
422938 NM 001809 Hs 1594 centromere protein A ( 17kD) 3 1
426318 AA375125 Hs 147112 Homo sapiens cDNA FU22322 fis, clone H 31
428896 AW291932 Hs 98936 ESTs 3 1
449277 AA001064 Hs 43670 ESTs 3 1
426509 M31166 Hs 2050 pentaxin-related gene, rapidly induced b 31
412216 AW901517 gb RC5-NN1013-310300-021-C03 NN1013 Homo 31
428845 AL157579 Hs 153610 KIAA0751 gene product 3 1
431512 BE270734 Hs 2795 lactate dehydrogenase A 31
418113 AI272141 Hs 83484 SRY (sex determining region Y)-box 4 30
450661 AW952160 Hs 83849 ESTs 30
448448 NM 014954 Hs 21239 KIAA0985 protein 30
422631 BE218919 Hs 118793 hypothedcal protein FU 10688 30
419687 AI638859 Hs 227699 ESTs, Weakly similar to T2D3 HUMAN TRANS 30
450963 AI864668 Hs 48832 ESTs 30
435060 AI422719 Hs 120873 ESTs, Weakly similar to fork head like p 30
440274 R24595 Hs 7122 scrapie responsive protein 1 30
437438 AL359620 Hs 14217 hypothedcal protein DKFZp762P2111 30
435401 R44477 Hs 10056 hypothedcal protein FU14621 30
416737 AF154335 Hs 79691 UM domain protein 30
445314 AI689948 Hs 65489 Homo sapiens cDNA FU21517 fis, clone C 30
425870 R13406 Hs 56782 ESTs 30
425294 AF033827 Hs 155553 HNK-1 sulfotransferase 30
416404 AA180138 Hs 107924 ESTs 30
413995 BE048146 Hs 75671 syntaxin 1A (brain) 30
422798 R92347 Hs 34574 ESTs, Weakly similar to ALU1.HUMAN ALU S 30
426384 AI472078 Hs 303662 hypothedcal protein FU13189 (FU13189) 30
430147 R60704 Hs 234434 hairy/enhancer-of-spht related with YRP 30
425264 AA353953 Hs 20369 ESTs, Weakly similar to gonadotropin ind 30
406917 X65964 gb H sapiens nesdn gene 30
425262 D87119 Hs 155418 GS3955 protein 30
401558 ENSP00000220478* SECRETOGRANIN III 30
439345 AW444759 Hs 146171 ESTs 30
414865 AA157155 Hs 274414 hypothedcal protein FU14457 30
453976 BE463830 Hs 163714 ESTs 30
404283 ENSP00000244751* Copme-like protein KIA 30
432890 NM 014442 Hs 279751 sialic acid binding Ig-like lect 8 30
451491 AI972094 Hs 286221 Homo sapiens cDNA FU13741 fis, clone PL 30
442573 H93366 Hs 7567 branched chain aminotransferase 1, cytos 30
428361 NM 015905 Hs 183858 transcπpdonal intermediary factor 1 30
443753 AW367578 Hs 134749 ESTs 30
417868 AI078534 Hs 122592 ESTs 30
443898 AW804296 Hs 9950 Sec61 gamma 30
438869 AF075009 gb Homo sapiens full length insert cDNA 30
453900 AW003582 Hs 226414 ESTs, Weakly similar to ALU8 HUMAN ALU S 30
447714 AW296313 Hs 255537 ESTs 30
426581 AB040956 Hs 135890 KIAA1523 protein 30
421126 M74587 Hs 102122 insulin-like growth factor binding prote 30
410762 AF226053 Hs 66170 HSKM-B protein 30
431462 AW583672 Hs 256311 granin-like neuroendocnne pepdde precu 30
452221 C21322 Hs 288057 hypothedcal protein FU22242 30
412326 R07566 Hs 73817 small inducible cytokine A3 (homologous 30
428600 AW863261 Hs 242413 hypothedcal protein DKFZp434K1421 30
426501 AW043782 Hs 293616 ESTs 30
405558 Target Exon 30
421483 NM 003388 Hs 104717 hypothedcal protein MGC11333 30
448681 AL109781 Hs 21754 Homo sapiens mRNA full length insert cDN 30
452108 AW135982 Hs 203013 hypothedcal protein FU12748 30
429569 AA454993 Hs 138343 ESTs, Weakly similar to I78885 senne/th 30
450728 AW162923 Hs 25363 presenilm 2 (Alzheimer disease 4) 30
429371 NM.001703 Hs 200586 brain-specific angiogenesis inhibitor 2 30
437435 AA249439 Hs 27027 hypothedcal protein DKFZp762H1311 30
432188 AI362952 Hs 2928 solute earner family 7 (cadonic ammo 30
404632 NM_022490 Homo sapiens hypothetical prot 30
452619 AW298597 Hs 61884 Homo sapiens, clone IMAGE 4298026, mRNA, 30
421458 NM_003654 Hs 104576 carbohydrate (keratan sulfate Gal-6) sul 30
419038 AW134924 Hs 190325 ESTs 30
453563 AW608906 Hs 181163 hypothedcal protein MGC5629 30 405239 U89281 oxidadve 3 alpha hydroxysteroid dehydro 30
TABLE 17B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
408432 1058667.1 AW195262 R27868AW811262
410099 117647.1 AA081630 T08671 AI174254 D83874 AW959843 AA364503 AA693467 AW993370 BE327037 AA167714 N79906 AW901977 AW901980 W52882
T07735 AA484549 W60090 D52685 T23811 BE327043 AW901768 BE551237 AA917004 AA716027 AI439658 AA283724 AI805992 AI457096
AA084618 BE467736 AI092635 AI887863 AI697593 AA436618 AI167419 AI418634 T31586 AA436630 AA706191 AI041169 AI422304 T03534
AA211402 AI204899 AI366472 AW827081 AA788593 T32736 AI767935 AA167791 AA747914 AA663870 AI865504
410126 117761.1 BE169274 AW893230 AA210998 H24222 AA081774 BE000935 BE000834 AA334880 412216 1283670.1 AW901517 AW901523 AW901521 AW901547 412436 129439 1 AA665089 AA135130 AA484059 AA102419 AW877765 412799 132817 1 AI267606 AA121045 AA126521 412820 1330039.1 BE001236 BE001177 BE001180 BE001234 414372 143909.1 AA143654 AW753140AA213770AW970865AA569075 AA492132 416871 1626761 1 H98716 N90792 N24283 418512 176394.1 AW498974 T09332 R58460 AA350990 T33786 T30936 AA350905 T08592 T09274 AA224297 D54678 T08951 R15346 AW953188 AA350074
AW890649
419544 185760.2 AI909154 AA526337 AA244193 AI909153 420352 192979.1 BE258835 AW968316 AA258918 AW843305 R14744 AI580388 BE071923 R36280 420692 195649.1 AW976345 AA279423 AA761070 420886 197344 1 AA805453AA281379 422156 212379.1 N34524 AA305071 AW954803 AA502335 AI433430 AI203597 AW026670 AW265323 AW850787 AA317554 AW993643 AW835572 AW385512
AI334966 W32951 H62656 H53902 R88904 AW835732
422949 223184.1 AA319435 N56456 AA319377 AW961532 T48452 AA894424 423476 22861.1 AL035633 F11794 F11783 H18042 T66089 H29379 R19493 AW134660 AI299437 AL133995 AA057405 N78357 AA917450 AI002692 T09262 T65008
H29290 AI200874 AA894415 AI732887 AI791768 AI733447 AA988785 N62128 T09261 AW956936
423713 231290 1 AW754182 AW754198 AA329983 424945 245223 1 AI221919 Z19967 AA348780 AW964077 AW166028 BE540193 N94800 AA452368 N99604AI341345AW298800 AA724961 AA931158 AI741227
AI806660 AI982626 D81263 D53937 D52496 AA974487 AW043854 N50483 Z39997 AI492961 AI361526 F04002 AA452141 T23551 AI472655
AI193667 AI341984 N92658 T32870 R52664 N50428 AW089291 AI934175 AI423737 D60665
424947 245247 1 R77952 AA348809 AW959960 AW959962 AI565552 AW070702 AA973910 R85973 426413 266650.1 AA377823 AW954494 AI022688 426503 268283.1 AA380153 AA380233 AW963529 426919 273507.1 AL041228082004 D61361 AI203314 AI990307 AW900295 AI018308 AW087473 AW183530 AA393346 H50055 AA935601 428342 290035.2 AI739168 AA426249 AI199636 AW505198 AW977291 AA824583 AA883419 AA724079 AI015524 AI377728 AW293682 AI928140 AA731438 AI092404
AI085630 AA731340
429007 298301.1 D80642 AA443145 AU 19015 AW904500 429163 300543.1 AA884766 AW974271 AA592975 AA447312 429421 30431.1 AL031658 AI693758 AL040619 AW977914 AA811957 AI352198 AW104364 AA648367 AA897604 AW341668 AI201382 AL040620 430183 31412.2 BE010038 AA676833 AI311783 T86895 W68032 BE064393 BE064394 BE157228 BE183282 AI936370 AA552514 T67280 AA039909 430676 32168.1 AF084866AF084870 AF084864 AF084867 AF084869AF084865AF084868 AW818206 AW812038 BE144813 BE144812 AW812041 AW812040
AW812067 BE061583 BE061604 T05808 AI352469 AA580921 BE141783 BE141782 BE061601 AW814393 AW885029
430968 326269.1 AW972830 AA527647 AA489820 AA570362 433009 357371.1 AA761668 AA573621 R92814 R09670 433434 366095.1 AA588429 AI972567 AW504832 AI299694 433523 368873.1 H29882 AW665533 AW149901 AI572917 AA598500 AI686466 AI336390 AW864390 AW864320 435542 407744.1 AA687376 H74234 AW975503 438869 46651 1 AF075009 R63109 R63068 439086 46852.1 AF085947 H70981 H78989 439285 47065.1 AL133916 N79113AF086101 N76721 AW950828 AA364013 AW955684 AI346341 AI867454 N54784 AI655270 AI421279 AW014882 AA775552
N62351 N59253 AA626243 AI341407 BE175639 AA456968 AI358918 AA457077
439518 47334.1 W76326 AF086341 W72300 439566 47387.1 AF086387 77884 72711 439710 47550.1 AF086543 W96291 W96225 441102 509604.1 AA973905 Al 299888 AA917019 H63235 T90771 444168 593829.1 AW379879 AI126285 H12014 446692 689623.1 Z44514 AI352097 AI803984 AW235923 AW196558 AI954637 AI336983 447197 711623.1 R36075 AI366546 R36167 449625 8113.1 NM.014253 AF100772 BE088769 AL022718 BE161779 AW863569 BE161640 AL039060 BE168542 AW296554 AA323193 AA235370 AW779760
N48674 AI375997 R45432 D59344 AI203107 F07491 R35360 R25094 AI913631 AI498402 T61382 AI016320 N45526 T61415 AA331486
450375 83327.1 AA009647 AA131254 AA374293 AW954405 H04410 AW606284 AA151166 BE157467 BE157601 H04384 W46291 AW663674 H04021 H01532
AA190993 H03231 H59605 H01642 AA852876 AA113758 AA626915 AA746952 AI161014 AA099554 R69067
450582 83933.1 AI339732 AA010300 AW515041 AA768334 N29860 AA42S874 AA425118 AA865829 AW936878 451320 86576.1 AW118072 AI631982 T15734 AA224195 AI701458 W20198 F26326 AA890570 N90552 AW071907 AI671352 AI375892 T03517 R88265 AI124088
AA224388 AI084316 AI354686 T33652 AI140719 AI720211 T03490 AI372637 T15415 AW205836 AA630384 T03515 T33230 AA017131 AA443303
T33623 AI222556 T33511 T33785 AI419606 D55612
453331 96214.1 AI240665 T53681 N77468 H51833 AA147247 R75732 C18450 R73999 AI095755 T49904 H03868 AA411580 R33395 AA410586 T48869 D63292
R31981 H12498 H02668 AA035018 R75957 AI803329 R27528 R36203 AI809932 AI808765 R78948 AA411449 AA976929 AI378760 AI378620 T48870
R73906 R75632 H03612 AA909684 N50695 H02580 H12839 N58781 AA742532 Al 360919 H03502 BE208298 R68588 AI350463 R31935 AW069127
AA411621 R25671 R36105 H12451 H03869 H51263 AA035486 R25109 R25110 AA147933
453682 977454.1 T79703 T96307 AL079725 454171 1049240.1 AW854832 AW854798 AW854857 AW854816 AW854834 AW854817 457728 393853.1 AW974811 AA651634 AA650072 457876 42814.2 AI821940 N67106 AI744264 AA808846 AA643417 AA643416 Z70715 458912 823104.1 AI911066 AI933734 AI680888 AJ003599
TABLE 17C Pkey Unique number corresponding to an Eos probeset Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al * refers to the publication endded 'The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted
Nt.posidor i Indicates nucleodde posidons of predicted exons
Pkey Ref Strand Nt_posιdon
400533 6981826 Minus 277132-277595
400777 8131663 Plus 70745-71121
400850 1927150 Minus 4506-4691
401558 7139678 Plus 103510-104090
402145 8018280 Plus 113086-114800
402604 9909420 Plus 20393-20767
402855 9662953 Minus 59763-59909
403696 3135242 Minus 143467-143634
403790 8084957 Minus 87826-87947,89835-90002
404150 7534008 Plus 165811-165943
404283 2276311 Minus 99460-99564
404295 9856663 Minus 75747-75947
404541 8318559 Plus 103456-103664
404584 9857511 Plus 138651-139153
404632 9796668 Plus 45096-45229
404819 4678240 Plus 16223-16319,16427-16513,16736-16859,16941-17075,17170-17287,17389-17529,18261-18357,18443-18578
405239 7249119 Plus 144345-144464,144690-144836,151750-151883,152407-152484
405303 2078453 Minus 130607-130802
405331 3236226 Minus 32502 32690
405348 2914717 Minus 43310-43462
405558 1621110 Plus 45024644,5983-6083
405605 5836195 Minus 117070-117270
405819 4007557 Plus 2830-2967
TABLE 18A ABOUT 446 CNS-ENRICHED GENES SIGNIFICANTLY DOWN REGULATED IN GLIOBLASTOMA MULTIFORMA COMPARED TO NORMAL ADULT CNS Table 18A lists about 446 CNS-enπched genes significantly down-regulated in glioblastoma muldforma (GBM) compared to normal adult CNS tissues These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the rado of "average* normal CNS to "average" GBM was greater than or equal to 2 The "average" normal CNS level was set to the βS*1 percentile amongst vaπous normal CNS dssues The "average" GBM level was set to the 85°' percentile amongst vaπous tumor samples To ennch for CNS specific genes, the ratio of "average" CNS to "average" non-CNS normal adult dssues was calculated to be greater than or equal to 3 The "average" CNS level was set to the 85"' percendle amongst vanous CNS dssues The "average" normal non-CNS adult dssue level was set to the 95"' percendle amongst vanous non-CNS normal dssues In order to remove gene-specific background levels of non-specific hybndizadon, the lO" percendle value amongst vaπous non-malignant dssues was subtracted from both the numerator and the denominator before the rados were evaluated
Pkey Unique Eos probeset idendfier number ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene due
R1 Ratio of CNS to GLIOBLASTOMA MULTIFORMA
R2 Ratio of CNS to NON-CNS NORMAL ADULT TISSUES
Pkey ExAccn UnigenelD Unigene Title R1 R2
425489 M58594 Hs 1905 prolactm 388 10 5
410330 AW023630 Hs 159425 ESTs 234 23 4
430538 AB032435 Hs 242821 differendadon-associated Na-dependent 226 226
417275 X63578 Hs 295449 parvalbumin 224 60
453590 AF150278 Hs 33578 KIAA0820 protein 223 223
428505 AL035461 Hs 2281 chromogranm B (secretogranin 1) 21 8 21 8
453220 AB033089 Hs 32452 Homo sapiens mRNA for KIAA1263 protein. 199 199
411498 NM 014210 Hs 70499 ecotropic viral integradon site 2A 194 194
408040 AI266496 Hs 22905 ESTs, Weakly similar to RHG6 HUMAN RHO-G 194 19 4
435145 AI277259 Hs 116631 ESTs 185 38
407039 X00368 gb Human prolactm gene 5' region 181 181
409263 AA069573 Hs 50319 ESTs 168 16 8
449078 AK001256 Hs 22975 KIAA1576 protein 16 1 16 1
426968 U07616 Hs 173034 amphiphysin (Sdff-Mann syndrome with br 153 153
432298 AU 18812 Hs 274293 Homo sapiens mRNA, cDNA DKFZp761G1111 (f 15 1 15 1
424645 NM.014682 Hs 151449 KIAA0535 gene product 15 1 15 1
450590 AI701507 Hs 273740 ESTs 149 38
417175 R44558 Hs 940O2 ESTs 146 89
423449 AI497900 Hs 33067 ESTs 14 5 14 5
441869 NM 003947 Hs 8004 hundngtin-associated protein interacdn 144 149
405560 AW887701 hypothedcal protein FU20628 140 80
440209 H05049 Hs 247837 neurexin 3 139 187
439238 N47305 Hs 302161 ESTs 139 53
452022 AW072330 Hs 293875 ESTs 138 138
459080 AW192083 Hs 290855 ESTs 13 5 13 5
425649 U30930 Hs 158540 UDP glycosyltransferase 8 (UDP-galactose 134 386
413324 V00571 Hs 75294 corticotropin releasing hormone 13 2 13 2
443992 AW022228 Hs 322922 ESTs 13 1 13 1
410635 D58863 Hs 334372 choπonic somatomammotropin hormone 1 (p 129 66
420156 AW449258 Hs 6187 ESTs 125 125
416490 AF090116 Hs 79348 regulator of G-protem signalling 7 125 125
450757 BE081050 Hs 31570 ESTs, Weakly similar to KIAA1324 protein 122 32
410037 AB020725 Hs 58009 KIAA0918 prote 122 122
433940 H05129 cyclic AMP-regulated phosphoprotein, 21 120 120
434367 AB020700 Hs 3830 KIAA0893 protein 11 6 56
410657 AF063228 Hs 65248 dynein, cytoplasmic, intermediate polype 11 5 11 5 431988 AC002302 Hs 77202 protein kinase C, beta 1 11 2 105
451783 R42554 Hs 210862 T-box, brain, 1 11 2 11 2
453165 S74727 Hs 32042 aspartoacylase (aminoacylase 2, Canavan 107 107
452238 F01811 Hs 345757 ESTs 106 38
417167 AW206437 Hs 4290 ESTs 104 104
420033 D59502 Hs 292590 ESTs 104 104
427224 AL135554 Hs 101937 sine oculis homeobox (Drosophila) homolo 104 39
424153 AA451737 Hs 141496 MAGE-like 2 10 3 5 1
413293 AL047483 Hs 302498 GTP-binding protein homologous to Saccha 100 100
400438 AF185611 Hs 115352 Target 99 51
447750 AI422234 Hs 143434 contacdn 1 98 98
419347 C15944 Hs 90005 supeπorcervical ganglia, neural specifi 98 222
418207 C14685 Hs 34772 ESTs 98 98
413409 AI638418 Hs 1440 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 94 94
447746 AW015920 Hs 161359 ESTs 92 99
406311 NM 021979* Homo sapiens heat shock 70kD 9 1 11 5
444330 AI597655 Hs 49265 Esfs 91 91
426365 AA376667 Hs 10283 RNA binding odf protein 8B 90 41
427322 AK002017 Hs 176227 hypothetical protein FU11155 89 89
439450 R51613 Hs 125304 ESTs 87 83
429096 AB011106 Hs 196012 KIAA0534 protein 86 66
428652 AA584272 Hs 336224 transmembrane protein with EGF-like and 86 86
408814 N62499 Hs 176227 hypothedcal protein FU11155 86 86
410309 BE043077 Hs 278153 ESTs 85 85
408950 AA707814 Hs 14945 long fatty acyl-CoA synthetase 2 gene 85 85
426814 AF036943 Hs 172619 myelin transcnpdon factor 1-lιke 85 142
416851 AW963951 Hs 85618 ESTs 85 85
430004 U27768 Hs 227571 regulator of G-protem signalling 4 84 157
412155 R38167 Hs 12449 Homo sapiens transmembrane protein HTMP1 84 279
427061 AB032971 Hs 173392 KIAA1145 protein 84 84
412049 N53437 Hs 18268 adenylate kinase 5 83 107
452752 AW044058 Hs 33578 KIAA0820 protein 82 134
414699 AI815523 Hs 76930 synuclein, alpha (non A4 component of am 82 45
422756 AA441787 Hs 119689 glycoprotein hormones, alpha polypeptide 8 1 58
435648 H24347 Hs 27524 ESTs 8 1 8 1
429470 AI878901 Hs 203862 guanine nucleotide binding protein (G pr 80 80
416133 NM 001683 Hs 89512 ATPase, Ca transporting, plasma membrane 80 80
438208 AL041224 Hs 65379 ESTs 79 58
436427 AI344378 Hs 143399 ESTs 78 78
441005 Z41305 Hs 303172 Homo sapiens mRNA, cDNA DKFZp547G133 (fr 77 77
442023 AI187878 Hs 144549 ESTs 77 56
444458 BE041526 Hs 31746 hypothetical protein DKFZp547F072 77 77
429033 NM 007374 Hs 194756 sine oculis homeobox (Drosophila) homolo 76 55
450642 R39773 Hs 7130 copme IV 76 56
446544 AI631932 Hs 7047 ESTs, Weakly similar to Unknown [H sapie 75 124
438283 AI458931 Hs 37282 ESTs 75 75
437073 AI885608 Hs 94122 ESTs 75 75
408577 H50572 Hs 19515 ESTs, Highly similar to NRG3.HUMAN PRO-N 74 74
424264 D80400 Hs 239388 Human DNA sequence from clone RP1-304B14 73 73
441264 AA927170 Hs 23290 ESTs 73 73
450474 AW872844 Hs 117494 ESTs 72 72
425352 NM 000939 Hs 1897 proopiomelanocortm (adreπocorticotropin 72 6 1
450715 AI266484 Hs 31570 ESTs, Weakly similar to KIAA1324 protein 72 72
450181 H05254 Hs 201198 ESTs 72 72
415076 NM 000857 Hs 77890 guanylate cyclase 1 , soluble, beta 3 7 1 48
419318 AW969742 Hs 291005 ESTs 7 1 3 1
423003 AL120077 Hs 122967 kelch (Drosophιla)-lιke 2 (Mayven) 70 70
434460 AA478486 Hs 3852 KIAA0368 protein 70 48
433921 AA618174 gb nq14f01 s1 NCI_CGAP_Thy1 Homo sapiens 70 70
418940 H17739 Hs 288513 Human DNA sequence from clone RP5-899C1 70 70
410765 AI694972 Hs 66180 nucleosome assembly protein 1-lιke 2 70 80
457012 R41480 Hs 302754 ESTs 69 69
416018 AW138239 Hs 78977 proprotein convertase subdlism/kexin t 69 140
445898 AF070623 Hs 13423 Homo sapiens clone 24468 mRNA sequence 69 69
415669 NM 005025 Hs 78589 senne (or cysteine) proteinase inhibito 69 10 2
433558 AA833757 Hs 201769 ESTs, Weakly similar to T24435 hypothed 69 69
409031 AA376836 Hs 288856 ESTs 68 68
409339 AB020686 Hs 54037 ectonucleodde pyrophosphatase/phosphodi 68 36
436568 H12049 Hs 91564 ESTs 68 68
442593 R39804 Hs 31961 ESTs 67 67
437948 AA772920 Hs 303527 ESTs 67 248
412266 N59006 Hs 26133 ESTs 66 309
422980 N46569 Hs 76722 CCAAT/enhancer binding protein (C/EBP), 66 45 2
442026 AI243749 Hs 8074 brain specific angiogenesis inhibitor 3 65 65
429946 R49390 Hs 254129 KIAA1678 64 45
445279 R41900 Hs 22245 ESTs 64 64
428414 AL049980 Hs 184216 DKFZP564C152 protein 64 64
407868 NM 000950 Hs 40637 prolme-nch Gla (G-carboxyglutamic acid 64 33
434104 AF116691 Hs 116459 hypothedcal protein PR02198 64 40
443244 AI457235 Hs 166479 ESTs 63 30
442042 AI990506 Hs 8077 Homo sapiens mRNA, cDNA DKFZp547E184 (fr 62 62
444783 AK001468 Hs 62180 anillm (Drosophila Scraps homolog), act 62 432
428536 AI143139 Hs 2288 vιsιnιπ ιke 1 60 22 1 415114 D60468 Hs 94181 ESTs 60 60
448958 AB020651 Hs 22653 KIAA0844 protein 59 59
431467 N71831 Hs 256398 Homo sapiens mRNA, cDNA DKFZp434E0528 (f 59 60
447138 AI439112 Hs 93828 ESTs, Weakly similar to 2109260A B cell 58 58
414545 AA149287 Hs 76605 ESTs 58 36
418202 N48521 Hs 26549 KIAA1708 protein 58 58
410389 AW954049 Hs 8177 ESTs Weakly similar to PIHUB6 salivary 57 96
444124 R43097 Hs 6818 ESTs 57 93
408065 AW954272 gb EST366342 MAGE resequences, MAGC Homo 56 56
448533 AL119710 Hs 21365 nucleosome assembly protein 1-lιke 3 56 96
425523 AB007948 Hs 158244 KIAA0479 protein 56 350
459697 AA406062 Hs 98002 ESTs 56 54
408428 NM 014787 Hs 44896 DnaJ (Hsp40) homolog, subfamily B, membe 56 56
420111 AA255652 gb zs21h11 r1 NCI.CGAP.GCBI Homo sapiens 55 32
450149 AW969781 Hs 132863 Zic family member 2 (odd-paired Drosophi 54 54
424918 R13982 Hs 169309 myelm-associated oligodendrocyte basic 53 53
438202 AW169287 Hs 22588 ESTs 53 53
448605 AL109678 Hs 21597 Homo sapiens mRNA full length insert cDN 53 53
425580 L11144 Hs 1907 galanin 53 35
418866 T65754 gb yd 1c07 s1 Stratagene lung (937210) H 53 38
430091 AB032958 Hs 233023 KIAA1132 protein 53 49
448786 BE048842 Hs 179075 Homo sapiens cDNA FU11881 fis, clone HE 52 52
427283 AL119796 Hs 174185 ectonudeodde pyrophosphatase/phosphodi 52 30
415666 H72693 gb u03c11 r1 Soares fetal liver spleen 52 52
410240 AL157424 Hs 61289 synaptojamn 2 52 46
428784 Y12851 Hs 193470 puπnergic receptor P2X, ligand-gated to 52 77
446692 Z44514 Homo sapiens mRNA for KIAA1763 protein, 52 330
428508 BE252383 Hs 184668 SBBI31 protein 52 4 1
446353 AI290919 Hs 153661 ESTs 5 1 5 1
423135 N67655 Hs 26411 ESTs 5 1 82
437331 AL353933 Hs 21710 hypothetical protein DKFZp761G0313 5 1 51
413988 M81883 Hs 324784 glutamate decarboxylase 1 (brain, 67kD) 5 1 5 1
429859 NM 007050 Hs 225952 protein tyrosine phosphatase, receptor t 5 1 5 1
411379 AI8?6344 Hs 12554 ESTs, Weakly similar to NPL4 HUMAN NUCLE 50 11 2
408068 AW148652 Hs 167398 ESTs 50 50
415734 NM_014747 Hs 78748 KIAA0237 gene produd 50 274
439607 BE540565 Hs 159460 ESTs 50 56
425984 AW836277 Hs 165636 hypothedcal protein DKFZp761C07121 49 293
414631 AW970130 Hs 65406 ESTs 49 49
437117 AL049256 Hs 122593 ESTs 49 38
418527 AA450386 Hs 7149 Homo sapiens cDNA FLJ21950 fis, clone H 49 49
425073 W39609 Hs 22003 solute earner family 6 (neurotransmitte 49 49
455364 H72176 Hs 4273 hypothetical protein FU13159 49 49
443150 AI034467 Hs 34650 ESTs 49 76
422411 AW749443 Hs 22511 ESTs 49 120
414931 AK000342 Hs 77646 Homo sapiens mRNA, cD A DKFZp761M0223 (f 49 34
430456 AA314998 Hs 241503 hypothedcal protein 48 47
428186 AW504300 Hs 295605 mannosidase, alpha, class 2A, member 2 48 39
433516 AA595802 Hs 33410 ESTs, Weakly similar to T17279 hypotheti 48 48
427287 NM 014903 Hs 174188 KIAA0938 protein 48 48
416101 R24854 Hs 268806 ESTs 48 33
447252 R90916 Hs 12449 Homo sapiens transmembrane protein HTMP1 48 32
458268 AA428403 Hs 106131 ESTs 47 39
440105 AA694010 Hs 6932 Homo sapiens clone 23809 mRNA sequence 47 82
445102 AW204610 Hs 22270 ESTs 47 19 2
419643 F06066 Hs 91791 chromosome 11 open reading frame 25 47 47
414949 C15314 Hs 323349 ESTs 47 38
453534 NM 014796 Hs 33187 KIAA0748 gene product 47 47
445729 H21066 Hs 13223 Homo sapiens mRNA full length insert cDN 47 40
451032 W03692 Hs 323079 Homo sapiens mRNA, cDNA DKFZp564P116 (fr 47 49
434792 AA649253 Hs 132458 ESTs 47 38
447104 R19085 Hs 210706 Homo sapiens cDNA FU13182 fis, clone NT 47 30
430537 X62692 Hs 2593 phosphodiesterase 6B, cGMP-specific rod 46 46
453431 AF094754 Hs 32973 glycine receptor, beta 46 46
453302 NM 000838 Hs 32945 glutamate receptor, metabotropic 1 46 46
429876 AB028977 Hs 225974 KIAA1054 protein 46 168
451516 AI800515 Hs 12024 ESTs 46 63
433670 AA604405 gb no87h09 s1 NCLCGAP AA1 Homo sapiens 46 39
437380 AL359577 Hs 112198 Homo sapiens mRNA, cDNA DKFZp547M073 (fr 45 38
410366 AI267589 Hs 302689 hypothedcal protein 45 10 4
419191 U17195 Hs 89666 A kinase (PRKA) anchor protein 6 45 45
429290 AF203032 Hs 198760 neurofilament, heavy polypepdde (200kD) 45 33
424932 R14070 Hs 315369 Homo sapiens cDNA FU23075 fis, clone L 45 102
432736 AA788898 Hs 179902 transporter-like protein 44 40
421952 AA300900 Hs 98849 ESTs, Moderately similar to AF161511 1 H 44 32
428963 AW382682 Hs 258208 Homo sapiens clone MGC 15606, mRNA, com 43 33
435040 AI932350 Hs 152825 ESTs 43 47
451301 AI769514 Hs 209890 EST 43 43
452381 H23329 Hs 290880 ESTs, Weakly similar to ALU1.HUMAN ALU S 43 43
410305 AF030409 Hs 62185 solute earner family 9 (sodium/hydrogen 43 78
433109 N58907 Hs 162430 EST 43 39
431342 AW971018 Hs 21659 ESTs 43 80
447163 AW292770 Hs 5542 DnaJ (Hsp40) homolog, subfamily C, membe 43 34 422414 AW875237 Hs 13701 ESTs 42 53
439274 AF086092 Hs 48372 ESTs 42 18 3
423589 AA328082 Hs 209569 ESTs 42 42
429956 AI374651 Hs 22542 ESTs 42 32
427317 AB028955 Hs 175780 KIAA1032 protein 42 53
426847 S78723 Hs 298623 5-hydroxytryptamιne (serotonin) receptor 4 1 79
408206 AF041853 Hs 43670 kinesin family member 3A 4 1 4 1
433803 AI823593 Hs 27688 ESTs 4 1 4 1
413024 AF036268 Hs 75149 SH3-domaιn GRB2-lιke 2 4 1 40
448117 H49129 Hs 172982 ESTs 4 1 4 1
450600 BE079478 Hs 24880 ESTs 4 1 39
429550 AW293055 Hs 119357 ESTs 4 1 64
448681 AL109781 Hs 21754 Homo sapiens mRNA full length insert cDN 40 72
458694 F12832 Hs 3610 ESTs 40 40
452197 AW023595 Hs 232048 ESTs 40 40
423728 AW891294 Hs 132136 solute earner family 4, sodium bicarbon 40 79
429656 X05608 Hs 211584 neurofilament, light polypeptide (68kD) 40 13 1
448583 NM_015239 Hs 21542 KIAA1035 protein 40 40
419863 AW952691 Hs 93485 Homo sapiens mRNA, cDNA DKFZp7610191 (ft 39 21 4
442412 R77677 Hs 346644 ESTs 39 39
424001 W67883 Hs 137476 paternally expressed 10 39 54
440293 AI004193 Hs 22123 ESTs 39 39
422890 Z43784 ankyπn 3, node of Ranvier (ankyπn G) 39 36
426054 U12431 Hs 166109 ELAV (embryonic lethal, abnormal vision. 39 39
412949 AI471639 Hs 71913 ESTs 38 37
427457 AW779105 Hs 164682 ESTs 38 11 1
416530 U62801 Hs 79361 kallikrein 6 (neurosm, zyme) 38 44
442676 AI733585 Hs 130897 ESTs 38 38
434998 AW975157 Hs 26037 ESTs 37 37
424945 AI221919 hypothedcal protein FU 10582 37 305
415257 F03016 Hs 27513 ESTs 37 86
407886 AW969688 Hs 100826 ESTs 37 20 2
400844 NM 003105* Homo sapiens sortilin-related 37 3 1
456765 AI497900 Hs 33067 ESTs 37 37
430287 AW182459 Hs 125759 ESTs, Weakly similar to LEU5 HUMAN LEUKE 36 76
452667 T87219 Hs 13219 ESTs 36 36
436773 AW078629 PC4 and SFRS1 interacting protein 1 36 36
424120 T80579 Hs 290270 ESTs 36 14 7
446574 AI310135 Hs 335933 ESTs 36 35
432453 AI885537 Hs 27172 ESTs, Moderately similar to PC4259 fern 36 39
408119 W26213 Hs 101672 ESTs, Weakly similar to T00331 hypothed 36 36
449093 AB035356 Hs 22998 neurexin 1 36 36
439239 AI031540 Hs 235331 ESTs 36 49 5
451625 R56793 Hs 106576 alamne-glyoxylate aminotransferase 2-lι 36 4 1
435059 Z45270 Hs 235873 hypothedcal protein FU22672 36 48
423346 AI267677 Hs 127416 synaptoianin 1 36 20 1
442738 AW002370 Hs 131055 ESTs, Weakly similar to NPM HUMAN NUCLEO 35 35
442106 AW205881 Hs 326728 ESTs 35 32
449117 AW449310 Hs 210262 ESTs, Weakly similar to HSS2JHUMAN HEPAR 35 35
405819 NM 002578 Homo sapiens p21 (CDKNIA)-actι 35 135
452311 AW304029 Hs 252744 ESTs 35 35
448902 Z45998 Hs 22543 Homo sapiens mRNA, cDNA DKFZp761H912 (f 35 21 8
410224 M55513 Hs 150208 potassium voltage-gated channel, shaker- 34 34
400098 Eos Control 34 34
428001 H97428 Hs 219907 ESTs, Moderately similar to Transforming 34 59
437268 AI754847 Hs 227571 regulator of G-protem signalling 4 34 140
443682 AI383061 Hs 47248 ESTs, Highly similar to similar to Cdc14 34 33
417417 F05745 Hs 89512 ATPase, Ca transporting, plasma membrane 33 17 1
419629 AB020695 Hs 91662 KIAA0888 protein 33 134
419852 AW503756 Hs 286184 hypothedcal protein dJ551D25 33 4 1
417063 N50515 Hs 45061 ESTs 33 33
435071 D60683 Hs 35495 ESTs 33 33
446377 AW014022 Hs 170953 ESTs 33 33
412453 R20205 Hs 75236 ESTs 33 33
450561 R49674 Hs 25909 ESTs 33 33
423829 R44107 Hs 240905 ESTs 33 44
415527 F11624 gb HSC2ZD101 normalized infant brain cDN 33 33
427386 AW836261 Hs 6727 ESTs 33 33
425121 AI797511 Hs 154579 synaptotagmin I 32 39
452856 AF034799 Hs 30881 protein tyrosine phosphatase, receptor t 32 107
442879 AF032922 Hs 8813 syntaxin binding protein 3 32 32
417284 N62889 Hs 107242 Homo sapiens cDNA FU12965 fis, clone NT 32 32
416805 F13271 Hs 79981 Human clone 23560 mRNA sequence 32 67
429477 AI275514 Hs 6658 ESTs 32 32
453169 AB037815 Hs 32156 KIAA1394 protein 32 57
408039 AA131424 Hs 336636 ESTs 32 32
426269 H15302 Hs 168950 Homo sapiens mRNA, cDNA DKFZp566A1046 (f 3.2 22 1
409746 NM 004794 . Hs 56294 RAB33A, member RAS oncogene family 32 106
416874 H98752 Hs 42568 ESTs 32 60
453919 AW959912 Hs 7076 KIAA1705 protein 32 32
444861 R46789 Hs 76118 ubiquitin carboxyl-terminal esterase L1 32 32
433315 R96754 Hs 239706 GRB2-assocιated binding protein 1 32 3 1
419103 Z40229 Hs 96423 hypothedcal protein FU23033 32 84 424140 Z48051 Hs 141308 myelin oligodendrocyte glycoprotein 32 560
421790 AW896201 Hs 22654 sodium channel, voltage-gated, type I, a 32 41
432809 AA565509 Hs 131703 ESTs 3 1 99
445225 AI216555 Hs 202398 ESTs 3 1 55
424087 N69333 Hs 143434 contactin 1 31 3 1
437924 AI935344 Hs 164118 ESTs, Weakly similar to SL51 HUMAN SODIU 3 1 32
419683 AA248897 Hs 48784 ESTs 3 1 59
420173 AA256151 Hs 22999 ESTs 31 41
411666 AF106564 Hs 71346 neurofilament 3 (150kD medium) 31 66
416220 N49776 Hs 170994 hypothedcal protein MGC10946 3 1 45
425138 H08849 Hs 167464 glutamate receptor, lonotropic, N-methyl 31 42
422234 AF119818 Hs 113287 discs, large (Drosophila) homolog-associ 31 3 1
445194 AI215667 Hs 175044 ESTs 3 1 3 1
438054 AA776626 Hs 169309 ESTs 31 102
432149 AW614326 Hs 133483 ESTs, Weakly similar to T34549 probable 31 122
445725 AK000956 Hs 13209 hypothetical protein FU 10094 30 30
414245 BE148072 Hs 75850 WAS protein family, member 1 30 11 7
447673 AI823987 Hs 182285 ESTs 30 30
428392 H10233 Hs 2265 secretory granule, neuroendocnne protei 30 423
418410 AA811441 Hs 107393 chromosome 3 open reading frame 4 30 39
429024 AI652297 Hs 119302 complement-c1q tumor necrosis factor-rel 30 37
426919 AL041228 ELAV (embryonic lethal, abnormal vision, 30 90
424724 T06532 Hs 287709 Homo sapiens cDNA FU22674 fis, clone H 30 30
410011 AB020641 Hs 57856 PFTAIRE protein kinase 1 30 100
408947 AL080093 Hs 49117 Homo sapiens mRNA, cDNA DKFZp564N1662 (f 30 135
426325 028114 Hs 169309 myelm-associated oligodendrocyte basic 29 81 1
429006 AA443143 Hs 50929 hypothedcal protein FU13842 29 66
410711 AB002316 Hs 65746 KIAA0318 protein 29 6 1
415486 H12214 Hs 13284 ESTs, Weakly similar to 2109260A B cell 29 157
424474 AA308883 Hs 148680 ealcyon, D1 dopamine receptor-interacdn 29 36
448299 AA497044 Hs 20887 hypothetical protein FU 10392 29 11 5
419518 U79289 Hs 90798 Human clone 23695 mRNA sequence 29 36
426529 AF090100 Hs 170241 Homo sapiens clone IMAGE 23915 29 5 1
430347 NM 002039 Hs 239706 GRB2-assocιated binding protein 1 29 32
429401 AW296102 Hs 99272 ESTs, Weakly similar to S32567 A4 protei 29 61
450154 R15891 Hs 281587 Human (clone CTG-A4) mRNA sequence 29 59
434277 X77748 Hs 3786 glutamate receptor, metabotropic 3 28 285
424790 AL119344 Hs 13326 ESTs, Weakly similar to 2004399A chromos 28 231
416836 D54745 Hs 80247 cholecystokmin 28 68
449277 AA001064 Hs 43670 ESTs 28 85
451952 AL120173 Hs 301663 ESTs 27 192
408554 AA836381 Hs 315111 nuclear receptor co-repressor/HDAC3 comp 27 37
413408 R51793 Hs 1440 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 27 30
410343 AA084273 Hs 76561 ESTs, Weakly similar to S47072 finger pr 27 32
420489 AA815089 Hs 193513 ESTs 27 4 1
447359 NM 012093 Hs 18268 adenylate kinase 5 27 17 2
423731 T08814 gb EST06706 Infant Brain, Bento Soares H 27 40
409953 AA332277 Hs 57691 cadheπn 18, type 2 27 55
424481 R19453 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbac 27 11 5
449714 AB033015 Hs 23941 KIAA1189 protein 27 75
424922 BE386547 Hs 217112 hypothetical protein MGC10825 27 37
432447 X92681 Hs 2998 contactin 2 (axonal) 27 41
420071 AB028985 Hs 94806 ATP binding cassette, sub-family A (ABC1 27 51
438068 AI927209 Hs 306210 Homo sapiens cDNA FU23133 fis, clone L 26 5 1
418512 AW498974 diacylglycerol kinase, zeta (104kD) 26 79
447761 AF061573 Hs 19492 protocadheπn 8 26 63
448743 AB032962 Hs 21896 KIAA1136 protein 26 232
408547 AA574291 Hs 57837 ESTs 26 40
426380 AI291267 Hs 149990 ESTs 26 69
420898 AB002379 Hs 100113 KIAA0381 protein 26 37
440357 AA379353 Hs 20950 phospholysme phosphohisdd e inorganic 26 37
424572 M19650 2\3'-cyclιc nucleotide 3' phosphodieste 26 59
418338 NM 002522 Hs 84154 neuronal pentraxin I 25 6 1
427658 H61387 Hs 30868 nogo receptor 25 30
410359 R38624 Hs 106313 ESTs 25 63
449717 AB040935 Hs 23954 cerebral cell adhesion molecule 25 45
424458 M29273 Hs 1780 myelin associated glycoprotein 25 10 1
450133 AW969769 Hs 105201 ESTs 25 405
428976 AL037824 Hs 194695 ras homolog gene family, member I 25 17 4
454293 H49739 Hs 134013 ESTs, Moderately similar to HK61_HUMAN H 25 95
408447 AK002089 Hs 45080 Homo sapiens cDNA FU11227 fis, clone PL 25 39
414683 S78296 Hs 76888 hypothedcal protein MGC12702 25 7 1
422927 AW247388 Hs 301423 calcium binding protein 1 (calbra ) 25 30
449568 AL157479 Hs 23740 KIAA1598 protein 25 36
454053 AW023006 Hs 27172 ESTs, Moderately similar to PC4259 fern 25 36
428495 NM 013279 Hs 184640 hypothetical protein MGC10781 25 32
431096 AA324358 Hs 249227 Homo sapiens DNA, cosmid clones TN62 and 24 36
452371 R40990 Hs 21658 ESTs 24 33
424997 AL138167 Hs 96920 ESTs 24 62
450310 N62341 Hs 94116 ESTs 24 36
452898 AA814497 Hs 78792 ESTs 24 39
436734 AI937612 Hs 273758 hypothetical protein FU23112 24 47
421931 NM_000814 Hs 1440 gamma-aminobutync acid (GABA) A recepto 24 3 1 439428 AA835825 Hs 190490 ESTs 24 30
445255 NM 014841 Hs 12477 synaptosomal-associated protein, 91 kDa 24 8 1
436420 AA443966 Hs 31595 ESTs 24 37
408822 AW500715 Hs 57079 Homo sapiens cDNA FU 13267 fis, clone OV 24 30
451407 AA131376 Hs 343809 fibroblast growth factor 12B 24 72
419757 AA773820 Hs 63970 ESTs 24 33
446100 AW967109 Hs 13804 hypothetical protein dJ4620232 24 36
439199 R40373 Hs 26299 ESTs 23 95
427627 R87582 Hs 179915 guanine nucleodde binding protein (G pr 23 56
454048 H05626 Hs 6921 ESTs 23 99
412675 AA460716 Hs 9788 hypothedcal protein MGC10924 similar to 23 33
434811 AW971205 Hs 114280 ESTs 23 67
431677 AK000496 Hs 306989 hypothedcal protein FU20489 23 31
451386 AB029006 Hs 26334 spastic paraplegia 4 (autosomal dominant 23 31
447028 AI973128 Hs 167257 brain link proteιn-1 23 56
451050 AW937420 Hs 69662 ESTs 23 44
437397 AA349847 Hs 4221 hypothedcal protein DKFZp761H039 23 48
408838 AI669535 Hs 40369 ESTs 23 30
408777 U71204 Hs 47626 Ric (Drosophιla)-lιke, expressed in neur 23 38
453924 R49295 Hs 24886 ESTs 23 134
422709 AA315331 Hs 153485 ESTs 23 44
438911 AF085841 Hs 301920 ESTs 23 33
439108 AW163034 Hs 6467 synaptogyπn 3 22 69
420297 AI628272 Hs 88323 ESTs, Weakly similar to ALU1_HUMAN ALU S 22 41
404819 NM.002688* Homo sapiens peanut (Drosophi 22 58
422544 AB018259 Hs 118140 KIAA0716 gene product 22 11 8
433597 AA708205 Hs 100343 ESTs 22 11 0
440152 AB002376 Hs 7006 KIAA0378 protein 22 142
418375 NM 003081 Hs 84389 synaptosomal associated protein, 25kD 22 829
409892 AW956113 Hs 7149 gb EST368183 MAGE resequences, MAGD Homo 22 42
425287 R88249 Hs 155524 peanut (Drosophιla)-lιke 2 22 60
433657 AI244368 Hs 8124 PH domain containing protein in redna 1 22 50
438703 AI803373 Hs 31599 ESTs 22 62
428845 AL157579 Hs 153610 KIAA0751 gene product 22 67
417865 AW086059 Hs 6529 ESTs, Weakly similar to 178885 senne/th 22 35
425897 AA935315 Hs 48965 Homo sapiens cDNA FLJ21693 fis, clone C 22 32
419271 N34901 Hs 238532 ESTs 22 75
448548 R13209 Hs 21413 solute earner family 12, (potassium-chl 22 73
439415 F05538 Hs 4273 ESTs 22 31 3
415170 R44386 Hs 164578 ESTs 22 109
423641 AL137256 Hs 130489 ATPase, aminophospholipid traπsporter-li 2 1 62
443728 AI083876 Hs 148383 ESTs 21 4 1
452108 AW135982 Hs 203013 hypothetical protein FU12748 2 1 57
429037 X81895 Hs 194765 H sapiens GENX-5624 mRNA, 3' UTR 2 1 7 1
418900 BE207357 Hs 3454 KIAA1821 protein 2 1 43
421268 AI126821 Hs 30514 ESTs 2 1 42
446372 AB020644 Hs 14945 long fatty acyl-CoA synthetase 2 gene 2 1 156
425741 AF052152 Hs 159412 Homo sapiens clone 24628 mRNA sequence 2 1 65
450214 BE439763 Hs 227571 regulator of G-protem signalling 4 2 1 33
452738 AL133800 Hs 7086 hypothedcal protein MGC12435 2 1 35
447877 AI435184 Hs 164252 ESTs 2 1 51
422421 AA325138 Hs 235873 hypothetical protein FU 22672 2 1 83
432882 NM 013257 Hs 279696 serum glucocorticoid regulated kinase Ii 2 1 42
410631 AA086469 Hs 47171 ESTs 2 1 58
407808 AA663559 Hs 279789 histone deacetylase 3 21 57
424379 Z42034 Hs 93597 cycl -dependent kinase 5, regulatory su 2 1 32
448410 AK000227 Hs 21126 hypothetical protein FU20220 2 1 30
433932 AW954599 Hs 169330 neuronal protein 2 1 69
425130 AA448208 Hs 99163 ESTs 21 31
402027 Target Exon 20 35
435191 R15912 Hs 4817 Homo sapiens clone 24461 mRNA sequence 20 75
420547 AF155140 Hs 98738 gonadotropm-regulated tesdcular RNA he 20 107
404541 NM_030795 Homo sapiens stathmin like 4 ( 20 60
420050 AL118615 Hs 94653 neurochondπn 20 65
417868 AI078534 Hs 122592 ESTs 20 56
416602 NM 006159 Hs 79389 nel (chιcken)-lιke 2 20 32
436315 BE390513 Hs 27935 hypothetical protein MGC4837 20 42
439340 AB032436 Hs 6535 brain-specific Na-dependent inorganic ph 20 63
429900 AA460421 Hs 30875 ESTs 20 42
437762 T78028 Hs 154679 synaptotagmin I 20 46
425172 AA447729 Hs 12714 ESTs 20 31
419587 S62907 Hs 91343 gamma-aminobutync acid (GABA) A recepto 20 31
451734 NM 006176 Hs 26944 neurogranin (protein kinase C substrate, 20 49
423603 AB007880 Hs 129883 Homo sapiens KIAA0420 mRNA, complete eds 20 43
438277 AL022326 Hs 6139 syπaptogyπn 1 20 34
423767 H18283 Hs 132753 F-box only protein 2 20 32
434933 R91095 Hs 4276 KIAA1701 protein 20 61
426575 M74826 Hs 170808 glutamate decarboxylase 2 (pancreadc is 20 46
TABLE 188
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank accession numbers Pkey CAT Number Accession
408065 103646 AW954272 AI003154 AA059300 AA046911
415527 1539393 F11624 Z43212 H08936 R56332 H09256 R52303 R13075
415666 1543492 1 H72693 R08673 H72694 F20990 R08580
418512 176394.Ϊ AW498974 T09332 R58460 AA350990 T33786 T30936 AA350905 T08592 T09274 AA224297 D54678 T08951 R15346 AW953188 AA350074
AW890649
418866 179788J T65754 AA229857 AA229658 420111 190755J AA255652 AA280911 AW967920 AA262684 422890 222707 1 Z43784 R13382 AW572911 AA449369 H17037 R19603 AI632565 AW004030 BE502530 Z25032 AA805324 AA449241 AI651825 AI264863 AW196918
AA948267 AI953735 AI263703 AA319159 AW964436 AI903440 AW594171 AI867447 AW204071 AW956110 C15616 D81142 H17038 AW162343
T87230 AI3
423731 231466.1 T08814 H19198 AL120536 AA330218 AW961552 N47159 424572 24097 1 M19650 R18810 R18721 AW896146 AW889520 AA192362 AA176814 F12085 BE255264 BE251393 T65248 AA380585 AA380465 BE408684
AA459037 AW498869 AA776107 BE274289 D45269 M61958 AA378818 AW663180 AW672958 H08611 M78164 BE393721 AA348660 R36303
AW498662 AA019090 AA001
424945 245223 1 AI221919 Z19967 AA348780 AW964077 AW166028 BE540193 N94800 AA452368 N99604 AI341345 AW298800 AA724961 AA931158 AI741227
AI806660 AI982626 D81263 D53937 D52496 AA974487 AW043854 N50483 Z39997 AI492961 AI361526 F04002 AA452141 T23551 AI472655
AI193667 AI341
426919 273507.1 AL041228 D82004 D61361 AI203314 AI990307 AW900295 AI018308 AW087473 AW183530 AA393346 H50055 AA935601 433670 372721.1 AA604405 BE062234 AW748386 433921 377350.1 AA618174 AI114549 R36464 R36465 433940 37787 1 H05129 N63433 AI651350 AA984734 AI368716 N40915 AI989705 F09042 T03905 R88588 AF112220 436773 426857.1 AW078629 AI857375 N64357 AA731069 446692 689623_1 Z44514 AI352097 AI803984 AW235923 AW196558 AI954637 AI336983
TABLE 18C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al * refers to the pub cadon endded "The DNA sequence of human chromosome 22* Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons
Pkey Ref Strand NLposition
400844 9188605 Plus 24746-24872,25035-25204
402027 7622350 Plus 51645-51888,52917-53005
404541 8318559 Plus 103456-103664
404819 4678240 Plus 16223-16319,16427-16513,16736-16859,16941-17075,17170-17287,17389-17529,18261-18357,18443-18578
405560 183148 Plus 5495-5655,6077-6241 ,6495-6692
405819 4007557 Plus 2830-2967
406311 9211559 Minus 137114-139033
TABLE 19A ABOUT 356 CNS-ENRICHED GENES SIGNIFICANTLY DOWN-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS Table 19A lists about 356 CNS-ennched genes significantly down-regulated in glioblastoma compared to normal adult CNS tissues These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the ratio of "average" normal CNS to "average" glioblastoma was greater than or equal to 2 The "average" normal CNS level was set to the 85* percendle amongst vanous normal CNS dssues The "average* glioblastoma level was set to the 85l percendle amongst vaπous tumor samples To enπch for CNS specific genes, the rado of 'average* CNS to "average" non CNS normal adult dssues was calculated to be greater than or equal to 3 The "average" CNS level was set to the 85°' percentile amongst various CNS tissues The "average" normal non-CNS adult dssue level was set to the 95m percendle amongst vaπous non-CNS normal dssues In order to remove gene-specific background levels of non-specific hybndization, the 10" percentile value amongst non-malignant tissues was subtracted from both the numerator and the denominator before the rados were evaluated
Pkey Unique Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Tide Unigene gene dtle
R1 Ratio of CNS to Glioblastoma
R2 Ratio of CNS to NON-CNS NORMAL ADULT TISSUES
Pkey ExAccn UnigenelD Unigene Title R1 R2
425489 M58594 Hs 1905 prolacdπ 248 105
410330 AW023630 Hs 159425 ESTs 234 234
430538 AB032435 Hs 242821 differendadon-assoαated Na-dependent 226 226
417275 X63578 Hs 295449 parv albumin 224 60
428505 AL035461 Hs 2281 chromogranin B (secretogranin 1) 21 8 21 8
408040 AI266496 Hs 22905 ESTs Weakly similar to RHG6 HUMAN RHO-G 194 194
435145 AI277259 Hs 116631 ESTs 185 38
407039 X00368 gb Human prolacdn gene 5' region 18 1 18 1
409263 AA069573 Hs 50319 ESTs 168 168
432298 AL118812 Hs 274293 Homo sapiens mRNA, cDNA DKFZp761 G1111 (f 151 151
424645 NM.014682 Hs 151449 KIAA0535 gene product 15 1 151
416018 AWΪ38239 Hs 78977 proprotein convertase subdlisin/kexin t 140 140
405560 AW887701 hypothedcal protem FU 20628 139 80
452022 AW072330 Hs 293875 ESTs 138 138
413324 V00571 Hs 75294 corticotropin releasing hormone 132 132
411498 NM.014210 Hs 70499 ecotropic viral mtegradon site 2A 129 194
423449 AI497900 Hs 33067 ESTs 124 145
433940 H05129 cyclic AMP-regulated phosphoprotein, 21 120 120
410657 AF063228 Hs 65248 dynem cytoplasmic, intermediate polype 11 5 11 5
449078 AK001256 Hs 22975 KIAA1576 protein 11 0 161
410635 D58863 Hs 334372 choπonic somatomammotropin hormone 1 (p 11 0 66
453165 S74727 Hs 32042 aspartoacylase (aminoacylase 2, Canavan 107 107
417167 AW206437 Hs 4290 ESTs 104 104
420033 D59502 Hs 292590 ESTs 104 104
413293 AL047483 Hs 302498 GTP-binding protein homologous to Saccha 100 100 418207 C14685 Hs 34772 ESTs 98 98
417175 R44558 Hs 94002 ESTs 96 89
444330 AI597655 Hs 49265 ESTs 91 9 1
427322 AK002017 Hs 176227 hypothetical protein FU 11155 89 89
429096 AB011106 Hs 196012 KIAA0534 protein 86 86
428652 AA584272 Hs 336224 transmembrane protein with EGF- ke and 86 86
419347 C15944 Hs 90005 supeπorcervical ganglia, neural specifi 86 222
410309 BE043077 Hs 278153 ESTs 85 85
416851 AW963951 Hs 85618 ESTs 85 85
427061 AB032971 Hs 173392 KIAA1145 protein 84 84
400438 AF185611 Hs 115352 Target 83 51
440209 H05049 Hs 247837 neurexin 3 82 18 7
422756 AA441787 Hs 119689 glycoprotein hormones, alpha polypeptide 81 58
435648 H24347 Hs 27524 ESTs 81 8 1
429470 AI878901 Hs 203862 guanine nucleotide binding protein (G pr 80 80
416133 NM 001683 Hs 89512 ATPase, Ca transporting, plasma membrane 80 80
408814 N62499 Hs 176227 hypothedcal protein FU11155 79 86
430004 U27768 Hs 227571 regulator of G-protem signalling 4 79 157
436427 AI344378 Hs 143399 ESTs 78 78
434367 AB020700 Hs 3830 KIAA0893 protein 78 56
429876 AB028977 Hs 225974 KIAA1054 protein 78 168
441005 Z41305 Hs 303172 Homo sapiens mRNA, cDNA DKFZp547G133 (fr 77 77
442023 AI187878 Hs 144549 ESTs 77 56
429033 NM 007374 Hs 194756 sine oculis homeobox (Drosophila) homolo 76 55
450642 R39773 Hs 7130 copine IV 76 56
437073 AI885608 Hs 94122 ESTs 75 75
441264 AA927170 Hs 23290 ESTs 73 73
424153 AA451737 Hs 141496 MAGE-like 2 73 51
450474 AW872844 Hs 117494 ESTs 72 72
450715 AI266484 Hs 31570 ESTs, Weakly similar to KIAA1324 protein 72 72
415076 NM 000857 Hs 77890 guanylate cyclase 1, soluble, beta 3 7 1 48
423003 AL120077 Hs 122967 kelch (Drosophιla)-lιke 2 (Mayven) 70 70
433921 AA618174 gb nq14f01 s1 NCI_CGAP_Thy1 Homo sapiens 70 70
425352 NM 000939 Hs 1897 proopiomelanocortin (adrenocorticotropin 69 6 1
457012 R 1480 Hs 302754 ESTs 69 69
445898 AF070623 Hs 13423 Homo sapiens clone 24468 mRNA sequence 69 69
433558 AA833757 Hs 201769 ESTs, Weakly similar to T24435 hypotheti 69 69
409031 AA376836 Hs 288856 ESTs 68 68
453590 AF150278 Hs 33578 KIAA0820 protein 66 223
450181 H05254 Hs 201198 ESTs 66 72
425580 L11144 Hs 1907 galanm 65 35
445279 R41900 Hs 22245 ESTs 64 64
428414 AL049980 Hs 184216 DKFZP564C152 protein 64 64
434104 AF116691 Hs 116459 hypothetical protein PR02198 64 40
443244 AI457235 Hs 166479 ESTs 63 30
447750 AI422234 Hs 143434 contactin 1 62 98
415114 D60468 Hs 94181 ESTs 60 60
450600 BE079478 Hs 24880 ESTs 59 39
444458 BE041526 Hs 31746 hypothetical protein DKFZp547F072 59 77
448958 AB020651 Hs 22653 KIAA0844 protein 59 59
447138 AI439112 Hs 93828 ESTs, Weakly similar to 2109260A B cell 58 58
414545 AA149287 Hs 76605 ESTs 58 36
410389 AW954049 Hs 8177 ESTs, Weakly similar to PIHUB6 salivary 56 96
450590 AI701507 Hs 273740 ESTs 56 38
408428 NM 014787 Hs 44896 DnaJ (Hsp40) homolog subfamily B membe 56 56
442026 AI243749 Hs 8074 brain-specific angiogenesis inhibitor 3 55 65
450149 AW969781 Hs 132863 Zic family member 2 (odd-paired Drosophi 54 54
414699 AI815523 Hs 76930 synuclein, alpha (non A4 component of am 53 45
438202 AW169287 Hs 22588 ESTs 53 53
448605 AL109678 Hs 21597 Homo sapiens mRNA full length insert cDN 53 53
418866 T65754 gb yd 1c07 s1 Stratagene lung (937210) H 53 38
448786 BE048842 Hs 179075 Homo sapiens cDNA FU11881 fis, clone HE 52 52
406311 NM_021979* Homo sapiens heat shock 70kD 52 11 5
443682 AI383061 Hs 47248 ESTs, Highly similar to similar to Cdc14 52 33
415666 H72693 gb yu03c11 r1 Soares fetal liver spleen 52 52
416101 R24854 Hs 268806 ESTs 52 33
428508 BE252383 Hs 184668 SBBI31 protein 52 4 1
419318 AW969742 Hs 291005 ESTs 52 3 1
439238 N47305 Hs 302161 ESTs 5 1 53
446353 AI290919 Hs 153661 ESTs 5 1 5 1
412049 N53437 Hs 18268 adenylate kinase 5 5 1 107
437331 AL353933 Hs 21710 hypothetical protein DKFZp761G0313 5 1 5 1
413988 M81883 Hs 324784 glutamate decarboxylase 1 (brain, 67kD) 5 1 51
408068 AW148652 Hs 167398 ESTs 50 50
414631 AW970130 Hs 65406 ESTs 49 49
418527 AA450386 Hs 7149 Homo sapiens cDNA FU21950 fis, clone H 49 49
425073 W39609 Hs 22003 solute earner family 6 (neurotransmitte 49 49
427224 AL135554 Hs 101937 sine oculis homeobox (Drosophila) homolo 49 39
433516 AA595802 Hs 33410 ESTs, Weakly similar to T17279 hypotheti 48 48
427287 NM 014903 Hs 174188 KIAA0938 protein 48 48
447252 R90916 Hs 12449 Homo sapiens transmembrane protein HTMP1 48 32
424932 R14070 Hs 315369 Homo sapiens cDNA FU23075 fis clone L 47 10 2
419643 F06066 Hs 91791 chromosome 11 open reading frame 25 47 47 414949 C15314 Hs 323349 ESTs 47 38
453534 NM 014796 Hs 33187 KIAA0748 gene product 47 47
430537 X62692 Hs 2593 phosphodiesterase 6B, cGMP-specific, rod 46 46
453431 AF094754 Hs 32973 glycine receptor beta 46 46
453302 NM_000838 Hs 32945 glutamate receptor, metabotropic 1 46 46
447104 R19085 Hs 210706 Homo sapiens cDNA FU13182 fis, clone NT 46 30
418202 N48521 Hs 26549 KIAA1708 protein 46 58
419191 U17195 Hs 89666 A kinase (PRKA) anchor protein 6 45 45
459080 AW192083 Hs 290855 ESTs 45 135
451783 R42554 Hs 210862 T-box, brain, 1 44 11 2
421952 AA3009OO Hs 98849 ESTs, Moderately similar to AF161511 1 H 44 32
451050 AW937420 Hs 69662 ESTs 44 44
423728 AW891294 Hs 132136 solute earner family 4, sodium bicaitoon 44 79
447746 AW015920 Hs 161359 ESTs 43 99
451301 AI769514 Hs 209890 EST 43 43
452381 H23329 Hs 290880 ESTs, Weakly similar to ALU1 HUMAN ALU S 43 43
433109 N58907 Hs 162430 EST 43 39
412155 R38167 Hs 12449 Homo sapiens transmembrane protein HTMP1 43 279
426365 AA376667 Hs 10283 RNA binding odf protein 88 43 4 1
423589 AA328082 Hs 209569 ESTs 42 42
432453 AI885537 Hs 27172 ESTs, Moderately similar to PC4259 fern 42 39
420489 AA815089 Hs 193513 ESTs 4 1 4 1
427457 AW779105 Hs 164682 ESTs 4 1 11 1
408206 AF041853 Hs 43670 kinesin family member 3A 41 4 1
433803 AI823593 Hs 27688 ESTs 4 1 4 1
407868 NM 000950 Hs 40637 proliπe-πch Gla (G-carboxyglutamic acid 4 1 33
448117 H49129 Hs 172982 ESTs 41 41
442106 AW205881 Hs 326728 ESTs 4 1 32
450757 BE081050 Hs 31570 ESTs, Weakly similar to KIAA1324 protein 40 32
442042 AI990506 Hs 8077 Homo sapiens mRNA, cDNA DKFZp547E184 (fr 40 62
458694 F12832 Hs 3610 ESTs 40 40
452197 AW023595 Hs 232048 ESTs 40 40
448583 NM 015239 Hs 21542 KIAA1035 protein 40 40
418940 H17739 Hs 288513 Human DNA sequence from clone RP5-899C14 39 70
442412 R77677 Hs 346644 ESTs 39 39
440293 AI004193 Hs 22123 ESTs 39 39
433670 AA604405 gb no87h09 s1 NCI CGAP AA1 Homo sapiens 39 39
459697 AA406062 Hs 98002 ESTs 39 54
429290 AF203032 Hs 198760 neurofilament, heavy polypeptide (200kD) 39 33
426054 U12431 Hs 166109 ELAV (embryonic lethal, abnormal vision, 39 39
424001 W67883 Hs 137476 paternally expressed 10 38 54
442676 AI733585 Hs 130897 ESTs 38 38
410240 AL157424 Hs 61289 synaptoianin 2 38 46
409339 AB020686 Hs 54037 ectonudeodde pyrophosphatase/phosphodi 37 36
434998 AW975157 Hs 26037 ESTs 37 37
439450 R51613 Hs 125304 ESTs 37 83
455364 H72176 Hs 4273 hypothedcal protein FLJ13159 37 49
400844 NM 003105* Homo sapiens sortilin-related 37 3 1
456765 AI497900 Hs 33067 ESTs 37 37
452667 T87219 Hs 13219 ESTs 36 36
436773 AW078629 PC4 and SFRS1 interacting protein 1 36 36
453220 AB033089 Hs 32452 Homo sapiens mRNA for KIAA1263 protein, 36 199
432149 AW614326 Hs 133483 ESTs, Weakly similar to T34549 probable 36 122
408119 W26213 Hs 101672 ESTs, Weakly similar to T00331 hypotheti 36 36
449093 AB035356 Hs 22998 neurexin 1 36 36
426968 U07616 Hs 173034 amphiphysin (Sdff-Mann syndrome with br 36 153
410011 AB020641 Hs 57856 PFTAIRE protein kinase 1 36 100
442738 AW002370 Hs 131055 ESTs, Weakly similar to NPM_HUMAN NUCLEO 35 35
451032 W03692 Hs 323079 Homo sapiens mRN A, cDNA DKFZp564P116 (fr 35 49
449117 AW449310 Hs 210262 ESTs, Weakly similar to HSS2.HUMAN HEPAR 35 35
416490 AF090116 Hs 79348 regulator of G-protem signalling 7 35 125
412266 N59006 Hs 26133 ESTs 35 309
452311 AW304029 Hs 252744 ESTs 35 35
425649 U30930 Hs 158540 UDP glycosyltransferase 8 (UDP-galactose 35 386
410224 M55513 Hs 150208 potassium voltage-gated channel, shaker- 34 34
451516 AI800515 Hs 12024 ESTs 34 63
400098 Eos Control 34 34
424918 R13982 Hs 169309 myelm-associated oligodendrocyte basic 34 53
452238 F01811 Hs 345757 ESTs 33 38
417063 N50515 Hs 45061 ESTs 33 33
443992 AW022228 Hs 322922 ESTs 33 13 1
412453 R20205 Hs 75236 ESTs 33 33
450561 R49674 Hs 25909 ESTs 33 33
415527 F11624 gb HSC2ZD101 normalized infant brain cDN 33 33
427386 AW836261 Hs 6727 ESTs 33 33
423346 AI267677 Hs 127416 synaptoianin 1 32 20 1
431342 AW971018 Hs 21659 ESTs 32 80
448533 AL119710 Hs 21365 nucleosome assembly protein 1 -like 3 32 96
442879 AF032922 Hs 8813 syntaxin binding protein 3 32 32
417284 N62889 Hs 107242 Homo sapiens cDNA FLJ12965 fis clone NT 32 32
429477 AI275514 Hs 6658 ESTs 32 32
410343 AA084273 Hs 76561 ESTs, Weakly similar to S47072 finger pr 32 32
427317 AB028955 Hs 175780 KIAA1032 protein 32 53 408039 AA131424 Hs 336636 ESTs 32 32
428976 AL037824 Hs 194695 ras homolog gene family, member I 32 174
420297 AI628272 Hs 88323 ESTs, Weakly similar to ALU1_HUMAN ALU S 32 4 1
453919 AW959912 Hs 7076 KIAA1705 protein 32 32
428963 AW382682 Hs 258208 Homo sapiens clone MGC 15606, mRNA com 32 33
423829 R44107 Hs 240905 ESTs 31 44
424087 N69333 Hs 143434 contacdn 1 3 1 3 1
419852 AW503756 Hs 286184 hypothedcal protein dJ551D25 3 1 41
444783 AK001468 Hs 62180 anillin (Drosophila Scraps homolog), act 31 43 2
422234 AF119818 Hs 113287 discs, large (Drosophila) homolog-associ 31 31
446692 Z44514 Homo sapiens mRNA for KIAA1763 protein 31 330
437117 AL049256 Hs 122593 ESTs 31 38
405819 NM.002578 Homo sapiens p21 (CDKN1 A)-acd 3 1 135
452752 AW044058 Hs 33578 KIAA0820 protein 31 134
416220 N49776 Hs 170994 hypothedcal protein MGC10946 31 45
437380 AL359577 Hs 112198 Homo sapiens mRNA, cDNA OKFZp547M073 (fr 30 38
428001 H97428 Hs 219907 ESTs, Moderately similar to Transforming 30 59
445725 AK000956 Hs 13209 hypothedcal protein FU 10094 30 30
447673 AI823987 Hs 182285 ESTs 30 30
427283 AL119796 Hs 174185 ectonucleotide yrophosphatase/phosphodi 30 30
424724 T06532 Hs 287709 Homo sapiens cDNA FU22674 fis, clone H 30 30
408547 AA574291 Hs 57837 ESTs 30 40
433315 R96754 Hs 239706 GRB2-assocιated binding protein 1 30 31
439274 AF0860-2 Hs 48372 ESTs 30 183
410765 AI694972 Hs 66180 nucleosome assembly protein 1-lιke 2 30 80
458268 AA428403 Hs 106131 ESTs 30 39
424641 AB001106 Hs 151413 glia maturadon factor, beta 30 56
441869 NM 003947 Hs 8004 hundngdn-associated protein interacdn 30 149
442593 R39804 Hs 31961 ESTs 29 67
426380 AI291267 Hs 149990 ESTs 29 69
428536 AI143139 Hs 2288 visinin-like 1 29 22 1
417417 F05745 Hs 89512 ATPase. Ca transporting, plasma membrane 29 17 1
411379 AI816344 Hs 12554 ESTs, Weakly similar to NPL4 HUMAN NUCLE 29 11 2
422414 AW875237 Hs 13701 ESTs 29 53
428186 AW504300 Hs 295605 mannosidase, alpha, class 2A, member 2 29 39
419518 U79289 Hs 90798 Human clone 23695 mRNA sequence 29 36
426919 AL041228 ELAV (embiγonic lethal, abnormal vision, 29 90
446544 AI631932 Hs 7047 ESTs, Weakly similar to Unknown [H sapie 28 124
422411 A 749443 Hs 22511 ESTs 28 120
416874 H98752 Hs 42568 ESTs 28 60
448902 Z45998 Hs 22543 Homo sapiens mRNA, cDNA DKFZp761l1912 (f 28 21 8
430456 AA314998 Hs 241503 hypothetical protein 28 47
429859 NM 007050 Hs 225952 protein tyrosine phosphatase, receptor t 28 51
429656 X05608 Hs 211584 neurofilament light polypeptide (68kD) 28 13 1
437948 AA772920 Hs 303527 ESTs 28 248
440105 AA694010 Hs 6932 Homo sapiens clone 23809 mRNA sequence 28 82
414931 AK000342 Hs 77646 Homo sapiens mRNA, cDNA DKFZp761M0223 (f 28 34
416530 U62801 Hs 79361 kallikrein 6 (neurosm, zy e) 28 44
446574 AI310135 Hs 335933 ESTs 28 35
422890 Z43784 ankyπn 3, node of Ranvier (ankyπn G) 28 36
410711 AB002316 Hs 65746 KIAA0318 protein 27 6 1
422980 N46569 Hs 76722 CCAAT/enhancer binding protein (C/EBP), 27 452
408554 AA836381 Hs 315111 nuclear receptor co-repressor/HDAC3 comp 27 37
434460 AA478486 Hs 3852 KIAA0368 protein 27 48
431988 AC002302 Hs 77202 protein kinase C, beta 1 27 10 5
447163 AW292770 Hs 5542 DnaJ (Hsp40) homolog, subfamily C, membe 27 34
437924 AI935344 Hs 164118 ESTs, Weakly similar to SL51.HUMAN SODIU 26 32
424945 AI221919 hypothedcal protein FU10582 26 305
425984 AW836277 Hs 165636 hypothetical protein DKFZp761C07121 26 293
447761 AF061573 Hs 19492 protocadheπn 8 26 63
425138 H08849 Hs 167464 glutamate receptor, lonotropic, N methyl 26 42
436568 H12049 Hs 91564 ESTs 26 68
408065 AW954272 gb EST366342 MAGE resequences, MAGC Homo 26 56
430287 AW182459 Hs 125759 ESTs, Weakly similar to LEU5.HUMAN LEUKE 26 76
408777 U71204 Hs 47626 Ric (Drosophιla)-lιke expressed in neur 26 38
420173 AA256151 Hs 22999 ESTs 26 4 1
429550 AW293055 Hs 119357 ESTs 26 64
438068 AI927209 Hs 306210 Homo sapiens cDNA FU23133 fis, clone L 26 5 1
424264 D80400 Hs 239388 Human DNA sequence from clone RP1-304B14 26 73
432809 AA565509 Hs 131703 ESTs 26 99
407886 AW969688 Hs 100826 ESTs 25 202
445225 AI216555 Hs 202398 ESTs 25 55
415257 F03016 Hs 27513 ESTs 25 86
423135 N67655 Hs 26411 ESTs 25 82
438283 AI458931 Hs 37282 ESTs 25 75
454053 AW023006 Hs 27172 ESTs, Moderately similar to PC4259 fern 24 36
443150 AI034467 Hs 34650 ESTs 24 76
429956 AI374651 Hs 22542 ESTs 24 32
428392 H10233 Hs 2265 secretory granule, neuroendocnne protei 24 423
437268 AI754847 Hs 227571 regulator of G-protem signalling 4 24 140
426529 AF090100 Hs 170241 Homo sapiens clone IMAGE 23915 24 5 1
430347 NM_002039 Hs 239706 GRB2-assocιated binding protein 1 24 32
422949 AA319435 gb EST21657 Adrenal gland tumor Homo sap 24 74 451952 AL120173 Hs 301663 ESTs 24 192
434277 X77748 Hs 3786 glutamate receptor, metabotropic 3 24 285
422927 AW247388 Hs 301423 calcium binding protein 1 (calbram) 24 30
425121 AI797511 Hs 154679 synaptotagmin 1 24 39
435059 Z45270 Hs 235873 hypothedcal protein FU22672 24 48
446377 AW014022 Hs 170953 ESTs 24 33
452371 R40990 Hs 21658 ESTs 24 33
419103 Z40229 Hs 96423 hypothetical protein FU23033 24 84
427658 H61387 Hs 30868 nogo receptor 24 30
446100 AW967109 Hs 13804 hypothedcal protein dJ4620232 23 36
439607 BE540565 Hs 159460 ESTs 23 56
412949 AI471639 Hs 71913 ESTs 23 37
419757 AA773820 Hs 63970 ESTs 23 33
410037 AB020725 Hs 58009 KIAA0918 protein 23 122
451386 AB029006 Hs 26334 spasdc paraplegia 4 (autosomal dominant 23 31
409953 AA332277 Hs 57691 cadhenn 18, type 2 23 55
419629 AB020695 Hs 91662 KIAA0888 protein 23 134
434792 AA649253 Hs 132458 ESTs 23 38
429006 AA443143 Hs 50929 hypothedcal protein FU13842 23 66
445194 AI215667 Hs 175044 ESTs 23 31
422491 AA338548 Hs 117546 neuronadn 23 36
415734 NM.014747 Hs 78748 KIAA0237 gene product 23 274
434933 R91095 Hs 4276 KIAA1701 protein 22 61
424922 BE386547 Hs 217112 hypothedcal protein MGC10825 22 37
426325 D28114 Hs 169309 myelin-associated oligodendrocyte basic 22 81 1
424140 Z48051 Hs 141308 myelin oligodendrocyte glycoprotein 22 560
418410 AA811441 Hs 107393 chromosome 3 open reading frame 4 22 39
409746 NM 004794 Hs 56294 RAB33A, member RAS oncogene family 22 106
439239 AI031540 Hs 235331 ESTs 22 495
450310 N62341 Hs 94116 ESTs 22 36
453924 R49295 Hs 24886 ESTs 22 134
411666 AF106564 Hs 71346 neurofilament 3 (150kD medium) 22 66
404819 NM_002688* Homo sapiens peanut (Drosophi 22 58
449568 AL157479 Hs 23740 KIAA1598 protein 22 36
419271 N34901 Hs 238532 ESTs 22 75
424474 AA308883 Hs 148680 ealcyon, D1 dopamine receptor-interacdn 22 36
438208 AL041224 Hs 65379 ESTs 22 58
424458 M29273 Hs 1780 myelin associated glycoprotein 22 101
421790 AW896201 Hs 22654 sodium channel, voltage-gated, type I, a 22 4 1
432882 NMJ13257 Hs 279696 serum/glucocorticoid regulated kinase Ii 2 1 42
419863 AW952691 Hs 93485 Homo sapiens mRNA cDNA DKFZp761 D191 (fr 21 21 4
449277 AA001064 Hs 43670 ESTs 2 1 85
420156 AW449258 Hs 6187 ESTs 2 1 125
452738 AL133800 Hs 7086 hypothetical protein MGC 12435 21 35
410366 AI267589 Hs 302689 hypothetical protein 2 1 104
452106 AI141031 Hs 21342 ESTs 21 34
413409 AI638418 Hs 1440 DEAD/H (Asp-Glu Ala-Asp/His) box polypep 2 1 94
423641 AL137256 Hs 130489 ATPase, aminophospholipid transporter-li 2 1 62
410909 AW898161 Hs 53112 ESTs Moderately similar to ALU8 HUMAN A 2 1 125
410631 AA086469 Hs 47171 ESTs 2 1 58
412675 AA460716 Hs 9788 hypothetical protein MGC10924 similar to 2 1 33
448299 AA497044 Hs 20887 hypothetical protein FU10392 2 1 11 5
444124 R43097 Hs 6818 ESTs 2 1 93
408950 AA707814 Hs 14945 long fatty acyl-CoA synthetase 2 gene 2 1 85
432736 AA788898 Hs 179902 transporter-like protein 2 1 40
429024 AI652297 Hs 119302 complement-c1q tumor necrosis factor-rel 2 1 37
420071 AB028985 Hs 94806 ATP-bindmg cassette, sub-family A (ABC1 2 1 5 1
408822 AW500715 Hs 57079 Homo sapiens cDNA FU13267 fis, clone OV 2 1 30
424790 AL119344 Hs 13326 ESTs, Weakly similar to 2004399A chromos 21 231
426814 AF036943 Hs 172619 myelin transcnpdon factor 1-lιke 2 1 14 2
425130 AA448208 Hs 99163 ESTs 2 1 3 1
449714 AB033015 Hs 23941 KIAA1189 protein 20 75
439108 AW163034 Hs 6467 synaptogynn 3 20 69
415669 NM_005025 Hs 78589 serine (or cysteine) proteinase inhibito 20 102
435040 AI932350 Hs 152825 ESTs 20 47
440152 AB002376 Hs 7006 KIAA0378 protein 20 14 2
445102 AW204610 Hs 22270 ESTs 20 192
436734 AI937612 Hs 273758 hypothedcal protein FU23112 20 47
437414 AW894071 Hs 48448 hypothetical protein DKFZp547C176 20 64
418512 AW498974 diacylglycerol kinase, zeta (104kD) 20 79
453169 AB037815 Hs 32156 KIAA1394 protein 20 57
420050 AL118615 Hs 94653 neurochondπn 20 65
429900 AA460421 Hs 30875 ESTs 20 42
432447 X92681 Hs 2998 contactin 2 (axonal) 20 4 1
431677 AK000496 Hs 306989 hypothetical protein FLJ20489 20 3 1
452856 AF034799 Hs 30881 protein tyrosine phosphatase, receptor t 20 10 7
448681 AL109781 Hs 21754 Homo sapiens mRNA full length insert cDN 20 72
453754 AW972580 Hs 172753 ESTs 20 34
422544 AB018259 Hs 118140 KIAA0716 gene product 20 11 8
416836 D54745 Hs 80247 cholecystokinin 20 68
454048 H05626 Hs 6921 ESTs 20 99
425741 AF052152 Hs 159412 Homo sapiens clone 24628 mRNA sequence 20 65 TABLE 19B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
408065 103646.1 AW954272 AI003154 AA059300 AA046911
415527 1539393.1 F11624 Z43212 H08936 R56332 H09256 R52303 R13075
415666 1543492.1 H72693 R08673 H72694 F20990 R08580
418512 176394.1 AW498974 T09332 R58460 AA350990 T33786 T30936 AA350905 T08592 T09274 AA224297 D54678 T08951 R15346 AW953188 AA350074
AW890649
418866 179788 1 T65754 AA229857 AA229658 422890 222707.1 Z43784 R13382 AW572911 AA449369 H17037 R19603 AI632565 AW004030 BE502530 Z25032 AA805324 AA449241 AI651825 AI264863AW196918
AA948267 AI953735 AI263703 AA319159 AW964436 AI903440AW594171 AI867447 AW204071 AW956110 C15616 D81142 H17038 AW162343
T87230 AI3
422949 223184.1 AA319435 N56456 AA319377 AW961532 T48452AA894424 424945 245223.1 AI221919 Z19967 AA348780 AW964077 AW166028 BE540193 N94800 AA452368 N99604 AI341345 AW298800 AA724961 AA931158 AI741227
AI806660 AI982626 D81263 D53937 D52496 AA974487 AW043854 N50483 Z39997 AI492961 AI361526 F04002 AA452141 T23551 AI472655
AI193667 AI341
426919 273507.1 AL041228 D82004 D61361 AI203314 AI990307 AW900295 AI018308 AW087473 AW183530 AA393346 H50055 AA935601 433670 372721.1 AA604405 BE062234 AW748386 433921 377350 1 AA618174 Al 11 549 R36464 R36465 433940 37787.1 H05129 N63433 AI651350 AA984734 AI368716 N40915 AI989705 F09042 T03905 R88588 AF112220 436773 426857.1 AW078629 AI857375 N64357 AA731069 446692 689623.1 Z44514 AI352097 AI803984 AW235923 AW196558 AI954637 AI336983
TABLE 19C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publicadon endded "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Sfrand Indicates DNA strand from which exons were predicted NLposition Indicates nucleodde positions of predicted exons
Pkey F Ref Strand NLposition
400844 9188605 Plus 24746-24872,25035-25204
404819 4678240 Plus 16223-16319,16427-16513,16736-16859,16941-17075,17170-17287,17389-17529,18261-18357,18443-18578
405560 183148 Plus 5495-5655,6077-6241 ,6495-6692
405819 4007557 Plus 2830-2967
406311 9211559 Minus 137114-139033
TABLE 20A ABOUT 328 CNS-ENRICHED GENES SIGNIFICANTLY DOWN-REGULATED IN LOWER GRADE GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS Table 20A lists about 328 CNS-ennched genes significantly down-regulated in lower grade glioblastoma (LGG) compared to nomial adult CNS dssues These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the ratio of "average" normal CNS to "average" LGG was greater than or equal to 2 The "average" normal CNS level was set to the βS* percendle amongst various normal CNS dssues The "average" LGG level was set to the 85* percendle amongst vanous tumor samples To ennch for CNS specific genes the ratio of "average" CNS to "average" non-CNS no ial adult tissues was calculated to be greater than or equal to 3 The "average" CNS level was set to the 85* percendle amongst vaπous CNS dssues The "average" nomial non-CNS adult dssue level was set to the 95* percendle amongst various non-CNS normal dssues In order to remove gene-specific background levels of non-specific hybndizadon, the 10* percentile value amongst various non-malignant dssues was subtracted from both the numerator and the denominator before the rados were evaluated
Pkey Umqi ιe Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dtle
R1 Rado of CNS compared to LOWER GRADE GLIOBLASTOMA
R2 Rado of CNS compared to NON-CNS NORMAL ADULT TISSUE
Pkey ExAccn UnigenelD Unigene Tide R1 R2
425580 L11144 Hs 1907 galanm 33 1 35
425489 M58594 Hs 1905 prolactm 247 105
430538 AB032435 Hs 242821 differentiation-associated Na-dependent 226 226
417275 X63578 Hs 295449 parvalbumm 22 4 60
428505 AL035461 Hs 2281 chromogranin B (secretogranin 1) 21 8 21 8
408040 AI266496 Hs 22905 ESTs. Weakly similar to RHG6 HUMAN RHO-G 194 194
435145 AI277259 Hs 116631 ESTs 185 38
407039 X0O368 gb Human prolactm gene 5' region 18 1 18 1
428976 AL037824 Hs 194695 ras homolog gene family, member I 174 174
409263 AA069573 Hs 50319 ESTs 168 168
424645 NM 014682 Hs 151449 KIAA0535 gene product 15 1 15 1
416018 AW138239 Hs 78977 proprotein convertase subdlisin/kex t 140 14 0
405560 AW887701 hypothedcal protein FU20628 139 80
452022 AW072330 Hs 293875 ESTs 138 138
433940 H05129 cyclic AMP-regulated phosphoprotein, 21 120 120
413324 V00571 Hs 75294 corticotropin releasing hormone 120 132
410657 AF063228 Hs 65248 dynem cytoplasmic, intermediate polype 11 5 11 5
410330 AW023630 Hs 159425 ESTs 11 1 234
453165 S74727 Hs 32042 aspartoacylase (amiπoacylase 2. Canavaπ 10 7 10 7
420297 AI628272 Hs 88323 ESTs, Weakly similar to ALU1 HUMAN ALU S 105 4 1
417167 AW206437 Hs 290 ESTs 104 104
420033 D59502 Hs 292590 ESTs 104 104
413293 AL047483 Hs 302498 GTP-binding protein homologous to Saccha 100 100
426380 AI291267 Hs 149990 ESTs 98 69
410635 D58863 Hs 334372 choπoπic somatomammotropin hormone 1 (p 95 66
422756 AA441787 Hs 119689 glycoprotein hormones, alpha polypeptide 9 1 58 444330 AI597655 Hs 49265 ESTs 9 1 91
427322 AK002017 Hs 176227 hypothedcal protein FLJ 11155 89 89
421633 AF121860 Hs 106260 sorting nexin 10 86 67
429096 AB011106 Hs 196012 KIAA0534 protein 86 86
428652 AA584272 Hs 336224 transmembrane protein with EGF-like and 86 86
410309 BE043077 Hs 278153 ESTs 85 85
424932 R14070 Hs 315369 Homo sapiens cDNA FU 23075 fis, clone L 85 102
417175 R44558 Hs 94002 ESTs 84 89
427061 AB032971 Hs 173392 KIAA1145 protein 84 84
400438 AF185611 Hs 115352 Target 83 51
418207 C14685 Hs 34772 ESTs 82 98
440209 H05049 Hs 247837 neurexin 3 81 187
429876 AB028977 Hs 225974 KIAA1054 protein 8 1 168
429470 AI878901 Hs 203862 guanine nucleotide binding protein (G pr 80 80
430004 U27768 Hs 227571 regulator of G-protem signalling 4 79 157
436427 AI344378 Hs 143399 ESTs 78 78
408814 N62499 Hs 176227 hypothedcal protein FU11155 78 86
434367 AB020700 Hs 3830 KIAA0893 protein 77 56
441005 Z41305 Hs 303172 Homo sapiens mRNA, cDNA DKFZp547G133 (fr 77 77
416851 AW963951 Hs 85618 ESTs 77 85
429033 NM.007374 Hs 194756 sine oculis homeobox (Drosophila) homolo 76 55
437073 AI885608 Hs 94122 ESTs 75 75
441264 AA927170 Hs 23290 ESTs 73 73
450715 AI266484 Hs 31570 ESTs, Weakly similar to KIAA1324 protein 72 72
415076 NM 000857 Hs 77890 guanylate cyclase 1, soluble, beta 3 7 1 48
410011 AB020641 Hs 57856 PFTAIRE protein kinase 1 7 1 100
423003 AL120077 Hs 122967 kelch (Drosophιla)-lιke 2 (Mayven) 70 70
433921 AA618174 gb nq14f01 s1 NCI CGAP Thy1 Homo sapiens 70 70
457012 R41480 Hs 302754 ESTs 69 69
445898 AF070623 Hs 13423 Homo sapiens clone 24468 mRNA sequence 69 69
425352 NM 000939 Hs 1897 proopiomelanocortin (adrenocorticotropin 69 61
433558 AA833757 Hs 201769 ESTs, Weakly similar to T24435 hypothed 69 69
409031 AA376836 Hs 288856 ESTs 68 68
419347 C15944 Hs 90005 supenorcervical ganglia, neural specifi 65 222
445279 R41900 Hs 22245 ESTs 64 64
437414 AW894071 Hs 48448 hypothedcal protein DKFZp547C176 64 64
428414 AL049980 Hs 184216 DKFZP564C152 protein 64 64
434104 AF116691 Hs 116459 hypothedcal protein PR02198 64 40
443244 AI457235 Hs 166479 ESTs 63 30
447761 AF061573 Hs 19492 protocadheπn 8 63 63
450600 BE079478 Hs 24880 ESTs 62 39
427457 AW779105 Hs 164682 ESTs 62 11 1
416133 NM.001683 Hs 89512 ATPase, Ca transporting plasma membrane 61 80
432453 AI885537 Hs 27172 ESTs, Moderately similar to PC4259 fern 60 39
432298 AL118812 Hs 274293 Homo sapiens mRNA, cDNA DKFZp761 G1111 (f 60 151
415114 D60468 Hs 94181 ESTs 60 60
416101 R24854 Hs 268806 ESTs 59 33
448958 AB020651 Hs 22653 KIAA0844 protein 59 59
447138 AI439112 Hs 93828 ESTs, Weakly similar to 2109260A B cell 58 58
414545 AA149287 Hs 76605 ESTs 58 36
424153 AA451737 Hs 141496 MAGE-like 2 57 51
424641 AB001106 Hs 151413 glia maturation factor, beta 56 56
410389 AW954049 Hs 8177 ESTs, Weakly similar to PIHUB6 salivary 56 96
432149 AW61 326 Hs 133483 ESTs, Weakly similar to T34549 probable 56 122
408428 NM 014787 Hs 44896 DnaJ (Hsp40) homolog, subfamily B, membe 56 56
443912 R37257 Hs 184780 ESTs 55 6 1
442023 AI187878 Hs 144549 ESTs 55 56
450642 R39773 Hs 7130 copine IV 54 56
439772 AL365406 Hs 10268 Homo sapiens mRNA full length insert cDN 54 98
450149 AW969781 Hs 132863 Zic family member 2 (odd-paired Drosophi 54 54
438202 AW169287 Hs 22588 ESTs 53 53
448605 AL109678 Hs 21597 Homo sapiens mRNA full length insert cDN 53 53
418866 T65754 gb yd 1c07 s1 Stratagene lung (937210) H 53 38
448786 BE048842 Hs 1 9075 Homo sapiens CDNA FU11881 fis, clone HE 52 52
443682 AI383061 Hs 47248 ESTs, Highly similar to similar to Cdc14 52 33
415666 H72693 gb yu03c11 r1 Soares fetal liver spleen 52 52
428508 BE252383 Hs 184668 S8BI31 protein 52 4 1
446353 AI290919 Hs 153661 ESTs 5 1 5 1
442106 AW205881 Hs 326728 ESTs 5 1 32
437331 AL353933 Hs 21710 hypothedcal protein DKFZp761G0313 5 1 5 1
419318 AW969742 Hs 291005 ESTs 50 31
408068 AW148652 Hs 167398 ESTs 50 50
434149 Z43829 Hs 244624 hypothedcal protein MGC5469 50 50
439238 N47305 Hs 302161 ESTs 49 53
414631 AW970130 Hs 65406 ESTs 49 49
447104 R19085 Hs 210706 Homo sapiens cDNA FU13182 fis, clone NT 49 30
418527 AA450386 Hs 7149 Homo sapiens cDNA FU21950 fis, clone H 49 49
425073 W39609 Hs 22003 solute earner family 6 (neurotransmitte 49 49
433516 AA595802 Hs 33410 ESTs, Weakly similar to T17279 hypotheti 48 48
427287 NM 014903 Hs 174188 KIAA0938 protein 48 48
447252 R90916 Hs 12449 Homo sapiens transmembrane protein HTMP1 48 32
419643 F06066 Hs 91791 chromosome 11 open reading frame 25 47 47
414949 C15314 Hs 323349 ESTs 47 38 429900 AA460421 Hs 30875 ESTs 47 42
422949 AA319435 gb EST21657 Adrenal gland tumor Homo sap 47 74
430537 X62692 Hs 2593 phosphodiesterase 6B, cGMP-specific, rod 46 46
419191 U17195 Hs 89666 A kinase (PRKA) anchor protein 6 45 45
421952 AA300900 Hs 98849 ESTs, Moderately similar to AF161511 1 H 44 32
406311 NM 021979* Homo sapiens heat shock 70kD 44 11 5
451050 AW937420 Hs 69662 ESTs 44 44
423728 AW891294 Hs 132136 solute earner family 4, sodium bicarbon 44 79
411498 NM 014210 Hs 70499 ecotropic viral integradon site 2A 43 194
451301 AI769514 Hs 209890 EST 43 43
452381 H23329 Hs 290880 ESTs, Weakly similar to ALU1 HUMAN ALU S 43 43
433109 N58907 Hs 162430 EST 43 39
423589 AA328082 Hs 209569 ESTs 42 42
427224 AL135554 Hs 101937 sine oculis homeobox (Drosophila) homolo 42 39
420489 AA815089 Hs 193513 ESTs 4 1 4 1
408206 AF041853 Hs 43670 kinesin family member 3A 41 4 1
418202 N48521 Hs 26549 KIAA1708 protein 41 58
448117 H49129 Hs 172982 ESTs 41 4 1
412155 R38167 Hs 12449 Homo sapiens transmembrane protein HTMP1 40 279
458694 F12832 Hs 3610 ESTs 40 40
452197 AW023595 Hs 232048 ESTs 40 40
408547 AA574291 Hs 57837 ESTs 40 40
433447 U29195 Hs 3281 neuronal pentraxin II 40 37
448583 NM 015239 Hs 21542 KIAA1035 protein 40 40
442412 R77677 Hs 346644 ESTs 39 39
440293 AI004193 Hs 22123 ESTs 39 39
426365 AA376667 Hs 10283 RNA binding odf protein 8B 39 4 1
400844 NM_003105* Homo sapiens sordlin-related 39 3 1
426054 U12431 Hs 166109 ELAV (embryonic lethal, abnormal vision, 39 39
429290 AF203032 Hs 198760 neurofilament, heavy polypeptide (200kD) 38 33
408777 U71204 Hs 47626 Ric (Drosophιla)-lιke, expressed in neur 38 38
442676 AI733585 Hs 130897 ESTs 38 38
414699 AI815523 Hs 76930 synudein, alpha (non A4 component of am 38 45
436476 AA326108 Hs 33829 bHLH protein DEC2 38 33
434998 AW975157 Hs 26037 ESTs 37 37
412049 N53437 Hs 18268 adenylate kinase 5 37 107
416220 N49776 Hs 170994 hypothedcal protein MGC10946 37 45
459697 AA406062 Hs 98002 ESTs 37 54
435648 H24347 Hs 27524 ESTs 37 8 1
442042 AI990506 Hs 8077 Homo sapiens mRNA, cDNA DKFZp547E184 (fr 37 62
456765 AI497900 Hs 33067 ESTs 37 37
434933 R91095 Hs 4276 KIAA1701 protein 36 6 1
419518 U79289 Hs 90798 Human clone 23695 mRNA sequence 36 36
452667 T87219 Hs 13219 ESTs 36 36
436773 AW078629 PC4 and SFRS1 interacdng protein 1 36 36
408119 W26213 Hs 101672 ESTs, Weakly similar to T00331 hypothed 36 36
453534 NM 014796 Hs 33187 KIAA0748 gene product 36 47
449093 AB035356 Hs 22998 neurexin 1 36 36
442738 AW002370 Hs 131055 ESTs, Weakly similar to NPM HUMAN NUCLEO 35 35
447746 AW015920 Hs 161359 ESTs 35 99
449117 AW449310 Hs 210262 ESTs, Weakly similar to HSS2_HUMAN HEPAR 35 35
447750 AI422234 Hs 143434 contacdπ 1 35 98
453590 AF150278 Hs 33578 KIAA0820 protein 35 223
409339 AB020686 Hs 54037 ectonucleodde pyrophosphatase/phosphodi 35 36
410240 AL157424 Hs 61289 synaptojanin 2 35 46
410224 M55513 Hs 150208 potassium voltage-gated channel, shaker- 34 34
400098 Eos Control 34 34
450181 H05254 Hs 201198 ESTs 34 72
459080 AW192083 Hs 290855 ESTs 34 135
417063 N50515 Hs 45061 ESTs 33 33
424918 R13982 Hs 169309 myelin associated oligodendrocyte basic 33 53
453431 AF094754 Hs 32973 glycine receptor, beta 33 46
412453 R20205 Hs 75236 ESTs 33 33
450561 R49674 Hs 25909 ESTs 33 33
415527 F11624 gb HSC2ZD101 normalized infant brain cDN 33 33
426968 U07616 Hs 173034 amphiphysin (Sdff-Mann syndrome with br 33 153
427386 AW836261 Hs 6727 ESTs 33 33
424001 W67883 Hs 137476 paternally expressed 10 32 54
439450 R51613 Hs 125304 ESTs 32 83
442879 AF032922 Hs 8813 syntaxin binding protein 3 32 32
417284 N62889 Hs 107242 Homo sapiens cDNA FU12965 fis, clone NT 32 32
410343 AA084273 Hs 76561 ESTs, Weakly similar to S47072 finger pr 32 32
410909 AW898161 Hs 53112 ESTs, Moderately similar to ALU8JHUMAN A 32 125
453919 AW959912 Hs 7076 KIAA1705 protein 32 32
424087 N69333 Hs 143434 contactin 1 31 3 1
428963 AW382682 Hs 258208 Homo sapiens, clone MGC 15606, mRNA, com 3 1 33
419852 AW503756 Hs 286184 hypothedcal protein dJ551D2 5 3 1 4 1
422234 AF119818 Hs 113287 discs, large (Drosophila) homolog-associ 3 1 3 1
423829 R44107 Hs 240905 ESTs 31 44
443297 AI049864 Hs 133029 ESTs 31 3 1
453302 NM.000838 Hs 32945 glutamate receptor, metabotropic 1 3 1 46
405819 NM_002578 Homo sapiens p21 (CDKNIA)-acd 3 1 135
445725 AK000956 Hs 13209 hypothedcal protein FU 10094 30 30 447673 AI823987 Hs 182285 ESTs 30 30
433670 AA604405 gb no87h09 s1 NCI_CGAP_AA1 Homo sapiens 30 39
450757 BE081050 Hs 31570 ESTs, Weakly similar to KIAA 1324 protein 30 32
424724 T06532 Hs 287709 Homo sapiens cDNA FU22674 fis, clone H 30 30
433315 R96754 Hs 239706 GRB2-assocιated binding protein 1 30 3 1
451032 W03692 Hs 323079 Homo sapiens mRNA, cDNA DKFZp564P116 (fr 30 49
423346 AI267677 Hs 127416 synaptoianin 1 30 201
439274 AF086092 Hs 48372 ESTs 30 183
425649 U30930 Hs 158540 UDP glycosyltransferase 8 (UDP-galactose 29 386
441869 NM 003947 Hs 8004 hundngdn-associated protein interacdn 29 149
407868 NM 000950 Hs 40637 proline-nch Gla (G-carboxyglutamic acid 29 33
410765 AI694972 Hs 66180 nucleosome assembly protein 1-lιke 2 29 80
428001 H97428 Hs 219907 ESTs, Moderately similar to Transforming 28 59
448533 AL119710 Hs 21365 nucleosome assembly protein 1-lιke 3 28 96
425130 AA448208 Hs 99163 ESTs 28 31
408554 AA836381 Hs 315111 nuclear receptor co-repressor/HDAC3 comp 28 37
452238 F01811 Hs 345757 ESTs 28 38
446544 AI631932 Hs 7047 ESTs, Weakly similar to Unknown (H sapie 28 124
433803 AI823593 Hs 27688 ESTs 28 4 1
407728 AW071502 Hs 175931 ESTs 27 102
414931 AK000342 Hs 77646 Homo sapiens mRNA cDNA DKFZp761M0223 (f 27 34
410711 AB002316 Hs 65746 KIAA0318 protein 27 61
452738 AL133800 Hs 7086 hypothedcal protein MGC12435 27 35
451516 AI800515 Hs 12024 ESTs 27 63
454053 AW023006 Hs 27172 ESTs, Moderately similar to PC4259 fern 27 36
450474 AW872844 Hs 117494 ESTs 27 72
422414 AW875237 Hs 13701 ESTs 27 53
428186 AW504300 Hs 295605 mannosidase, alpha, dass 2A, member 2 27 39
431342 AW971018 Hs 21659 ESTs 27 80
423449 AI497900 Hs 33067 ESTs 26 145
427283 AL119796 Hs 174185 ectonucleodde pyrophosphatase/phosphodi 26 30
426919 AL041228 ELAV (embryonic lethal, abnormal vision, 26 90
437117 AL049256 Hs 122593 ESTs 26 38
422491 AA338548 Hs 117546 neuronadn 26 36
438068 AI927209 Hs 306210 Homo sapiens cDNA FU23133 fis, clone L 26 5 1
432809 AA565509 Hs 131703 ESTs 25 99
433551 AI985544 Hs 12450 protocadheπn 9 25 181
444783 AK001468 Hs 62180 anillm (Drosophila Scraps homolog), act 25 432
417417 F05745 HS 89512 ATPase, Ca transporting plasma membrane 25 17 1
413554 AA3191 6 Hs 75426 secretogranin II (chromograniπ C) 25 57
448902 Z45998 Hs 22543 Homo sapiens mRNA, cDNA DKFZp761H912 (f 25 21 8
442910 AI365130 Hs 11307 ESTs, Weakly similar to T19326 hypothed 25 145
423135 N67655 Hs 26411 ESTs 25 82
452311 AW304029 Hs 252744 ESTs 25 35
418940 H17739 Hs 288513 Human DNA sequence from clone RP5-899C14 25 70
432882 NM 013257 Hs 279696 serum/glucocorticoid regulated kmase-li 25 42
422411 AW749443 Hs 22511 ESTs 25 120
451386 AB029006 Hs 26334 spasdc paraplegia 4 (autosomal dominant 24 31
404819 NM.0O2688* Homo sapiens peanut (Drosophi 24 58
429656 X05608 Hs 211584 neurofilament light polypepdde (68kD) 24 13 1
431988 AC002302 Hs 77202 protein kinase C, beta 1 24 105
411379 AI816344 Hs 12554 ESTs, Weakly similar to NPL4.HUMAN NUCLE 24 11 2
422980 N46569 Hs 76722 CCAAT/enhancer binding protein (CEBP), 24 452
429859 , NM 007050 Hs 225952 protein tyrosine phosphatase receptor t 24 5 1
430287 AW182459 Hs 125759 ESTs, Weakly similar to LEU5.HUMAN LEUKE 24 76
422890 Z43784 aπkyπn 3, node of Ranvier (ankyππ G) 24 36
427658 H61387 Hs 30868 nogo receptor 24 30
446100 AW967109 Hs 13804 hypothedcal protein dJ4620232 23 36
412266 N59006 Hs 26133 ESTs 23 309
435059 Z45270 Hs 235873 hypothedcal protein FU22672 23 48
420173 AA256151 Hs 22999 ESTs 23 4 1
452371 R40990 Hs 21658 ESTs 23 33
430456 AA314998 Hs 241503 hypothetical protein 23 47
409953 AA332277 Hs 57691 cadhenn 18, type 2 23 55
429006 AA443143 Hs 50929 hypothedcal protein FU13842 23 66
445194 AI215667 Hs 175044 ESTs 23 3 1
428392 H10233 Hs 2265 secretory granule, neuroendocnne protei 23 423
434460 AA478486 Hs 3852 KIAA0368 protein 23 48
416490 AF090116 Hs 79348 regulator of G-protem signalling 7 23 125
437924 AI935344 Hs 164118 ESTs, Weakly similar to SL51.HUMAN SODIU 23 32
418738 AW388633 Hs 6682 solute earner family 7, (cationic ammo 22 169
424945 AI221919 hypothedcal protein FU10582 22 305
416530 U62801 Hs 79361 kailikrein 6 (neurosin, zyme) 22 44
422927 AW247388 Hs 301423 calcium binding protein 1 (calbra ) 22 30
438831 BE263273 Hs 6439 synapsm II 22 34
449078 AK001256 Hs 22975 KIAA1576 protein 22 16 1
410631 AA086469 Hs 47171 ESTs 22 58
419271 N34901 Hs 238532 ESTs 22 75
452752 AW044058 Hs 33578 KIAA0820 protein 22 134
446574 AI310135 Hs 335933 ESTs 22 35
452106 AI141031 Hs 21342 ESTs 22 34
415910 U20350 Hs 78913 chemokine (C-X3-C) receptor 1 22 289
444458 BE041526 Hs 31746 hypothetical protein DKFZp547F072 22 77 446692 Z44514 Homo sapiens mRNA for KIAA1763 protein, 22 330
412788 AA120960 Hs 198416 ESTs 22 85
419103 Z40229 Hs 96423 hypothetical protein FU23033 22 84
424474 AA308883 Hs 148680 ealcyon, D1 dopamine receptor-interacdn 22 36
451783 R42554 Hs 210862 T-box, brain, 1 2 1 11 2
434792 AA649253 Hs 132458 ESTs 2 1 38
424922 BE386547 Hs 217112 hypothedcal protein MGC10825 21 37
455364 H72176 Hs 4273 hypothetical protein FU13159 2 1 49
413988 M81883 Hs 324784 glutamate decarboxylase 1 (brain, 67kD) 2 1 51
452744 AI267652 Hs 246107 Homo sapiens mRNA cDNA DKFZp434E082 (fr 21 36
443150 AI034467 Hs 34650 ESTs 2 1 76
453220 A8033089 Hs 32452 Homo sapiens mRNA for KIAA1263 protein, 21 199
420050 AL118615 Hs 94653 neurochondπn 21 65
408449 NM.004408 Hs 166161 dynamin 1 21 51
423641 AL137256 Hs 130489 ATPase, aminophospholipid transporter-li 2 1 62
430347 NM 002039 Hs 239706 GRB2-assocιated binding protein 1 21 32
449568 AL157479 Hs 23740 KIAA1598 protein 21 36
412675 AA460716 Hs 9788 hypothedcal protein MGC10924 similar to 2 1 33
429550 AW293055 Hs 119357 ESTs 21 64
446782 AI653048 Hs 144006 ESTs 2 1 90
453924 R49295 Hs 24886 ESTs 2 1 134
437948 AA772920 Hs 303527 ESTs 21 248
451952 AL120173 Hs 301663 ESTs 20 19 2
453754 AW972580 Hs 172753 ESTs 20 34
448765 R15337 Hs 21958 Homo sapiens mRNA cDNA DKFZp547D086 (fr 20 39
447163 AW292770 Hs 5542 DnaJ (Hsp40) homolog, subfamily C, membe 20 34
448299 AA497044 Hs 20887 hypothedcal protein FLJ 10392 20 11 5
411666 AF106564 Hs 71346 neurofilament 3 (150kD medium) 20 66
424458 M29273 Hs 1780 myelin associated glycoprotein 20 10 1
434277 X77748 Hs 3786 glutamate receptor, metabotropic 3 20 285
440152 AB002376 Hs 7006 KIAA0378 protein 20 14 2
429956 AI374651 Hs 22542 ESTs 20 32
450590 AI701507 Hs 273740 ESTs 20 38
429024 AI652297 Hs 119302 complement-c1q tumor necrosis factor-rel 20 37
430643 AW970065 Hs 287425 MEGF10 protein 20 41
415734 NM 014747 Hs 78748 KIAA0237 gene product 20 27 4
419757 AA773820 Hs 63970 ESTs 20 33
421264 AL039123 Hs 103042 microtubule-associated protein 1B 20 238
439607 BE540565 Hs 159460 ESTs 20 56
435624 AF218942 Hs 24889 formin 2 20 12 2
425121 AI797511 Hs 154679 synaptotagmin I 20 39
431677 AK000496 Hs 306989 hypothedcal protem FU20489 20 31
442593 R39804 Hs 31961 ESTs 20 67
410366 AI267589 Hs 302689 hypothedcal protein 20 104
426575 M74826 Hs 170808 glutamate decarboxylase 2 (pancreatic is 20 46
452856 AF034799 Hs 30881 protein tyrosine phosphatase, receptor t 20 107
437380 AL359577 Hs 112198 Homo sapiens mRNA, cDNA DKFZp547M073 (fr 20 38
424893 AW295112 Hs 153648 Homo sapiens cDNA FU13303 fis, clone OV 20 38
436734 AI937612 Hs 273758 hypothedcal protein FU23112 20 47
422544 AB018259 Hs 118140 KIAA0716 gene product 20 11 8
440105 AA694010 Hs 6932 Homo sapiens clone 23809 mRNA sequence 20 82
425741 AF052152 Hs 159412 Homo sapiens clone 24628 mRNA sequence 20 65
450310 N62341 Hs 94116 ESTs 20 36
TABLE 20B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
415527 1539393.1 F11624 Z43212 H08936 R56332 H09256 R52303 R13075
415666 1543492.1 H72693 R08673 H72694 F20990 R08580
418866 179788.1 T65754 AA229857 AA229658
422890 222707.1 Z43784 R13382 AW572911 AA449369 H17037 R19603 AI632565 AW004030 BE502530 Z25032 AA805324 AA449241 AI651825 AI264863 AW196918
AA948267 AI953735 AI263703 AA319159 AW964436 AI903440 AW594171 AI867447 AW204071 AW956110 C15616 D81142 H17038 AW162343
T87230 AI3
422949 223184.1 AA319435 N56456 AA319377 AW961532 T48452 AA894424 424945 245223.1 AI221919 Z19967 AA348780 AW964077 AW166028 BE540193 N94800 AA452368 N99604 AI341345 AW298800 AA724961 AA931158 AI741227
AI806660 AI982626 D81263 D53937 D52496 AA974487 AW043854 N50483 Z39997 AI492961 AI361526 F04002 AA4521 1 T23551 AI472655
AI193667 AI341
426919 273507.1 AL041228 D82004 061361 AI203314 AI990307 AW900295 AI018308 AW087473 AW183530 AA393346 H50055 AA935601 433670 372721.1 AA604405 BE062234 AW748386 433921 377350.1 AA618174 AI114549 R36464 R36465 433940 37787.1 H05129 N63433 AI651350 AA984734 AI368716 N40915 AI989705 F09042 T03905 R88588 AF112220 436773 426857.1 AW078629 AI857375 N64357 AA731069 446692 689623.1 Z44514 AI352097 AI803984 AW235923 AW196558 AI954637 AI336983
TABLE 20C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publicadon entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted Nt_posidon Indicates nucleotide posidons of predicted exons Pkey Ref Strand Nt.posιdon
400844 9188605 Plus 24746-24872,25035-25204
404819 4678240 Plus 16223-16319 16427-16513,16736-16859,16941-17075 17170-17287,17389-17529,18261-18357,18443-18578
405560 183148 Plus 5495-5655,6077-6241 ,6495-6692
405819 4007557 Plus 2830-2967
406311 9211559 Minus 137114-139033 TABLE 21A ABOUT 410 GENES SIGNIFICANTLY DOWN-REGULATED IN GLIOBLASTOMA MULTIFORMA COMPARED TO NORMAL ADULT CNS
Table 21 A lists about 410 genes significantly down-regulated in glioblastoma multiforma (GBM) compared to normal adult CNS dssues These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the rado of "average" normal CNS to "average" GBM was greater than or equal to 2 The "average" normal CNS level was set to the 75* percendle amongst vanous normal CNS dssues The "average" GBM level was set to the 95* percendle amongst vaπous tumor samples In order to remove gene-specific background levels of non-specific hybπdizadon, the 10* percendle value amongst vanous non-malignant dssues was subtracted from both the numerator and the denominator before the rado was evaluated
Pkey Unique Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene title R1 Rado of CNS to GLIOBLASTOMA MULTIFORMA
Pkey ExAccn UnigenelD Unigene Tide R1
417275 X63578 Hs 295449 parvalbumin 186
428505 AL035461 Hs 2281 chromogranin B (secretogramn 1) 138
415672 N53097 Hs 193579 ESTs 135
459080 AW192083 Hs 290855 ESTs 129
432298 AL118812 Hs 274293 Homo sapiens mRNA, cDNA DKFZp761G1111 (f 11 7
400302 N48056 Hs 1915 folate hydrolase (prostate-specific memb 109
418318 U47732 Hs 84072 transmembrane 4 superfamily member 3 10 1
424645 NM 014682 Hs 151449 KIAA0535 gene product 82
415274 AF001548 Hs 78344 myosin, heavy polypeptide 11, smooth mus 75
413324 V00571 Hs 75294 corticotropin releasing hormone 75
417167 AW206437 Hs 4290 ESTs 73
422728 AW937826 Hs 103262 ESTs, Weakly similar to ZN91 HUMAN ZINC 68
410330 AW023630 Hs 159425 ESTs 65
450590 AI701507 Hs 273740 ESTs 65
453165 S74727 Hs 32042 aspartoacylase (aminoacylase 2, Canavan 65
454076 AW204712 Hs 61957 ESTs 63
419956 AL137939 Hs 40096 ESTs 63
416851 AW963951 Hs 85618 ESTs 62
428874 W32133 Hs 194366 transthyredn (prealbumin, amyloidosis t 60
409743 N48721 Hs 183506 hypothetical protein FU14213 59
449078 AK001256 Hs 22975 KIAA1576 protein 56
448072 AI459306 Hs 24908 ESTs 56
412622 AW664708 Hs 171959 ESTs 56
428414 AL049980 Hs 184216 DKFZP564C152 protein 55
427322 AK002017 Hs 176227 hypothetical protein FU 11155 55
411498 NM 014210 Hs 70499 ecotropic viral integration site 2A 54
453344 BE349075 Hs 44571 ESTs 54
441790 AW294909 Hs 132208 ESTs 53
443037 AW500305 Hs 8906 syntaxin 7 53
445529 H14421 Hs 180513 ATP-bmding cassette, sub-family A (ABC1 52
447750 AI422234 Hs 143434 contactin 1 52
444409 AI792140 Hs 49265 ESTs 52
409031 AA376836 Hs 288856 ESTs 5 1
453220 AB033089 Hs 32452 Homo sapiens mRNA for Kl AA1263 protein, 50
452022 AW072330 Hs 293875 ESTs 49
408428 NM 014787 Hs 44896 DnaJ (Hsp40) homolog, subfamily B, membe 48
444922 AI921750 Hs 144871 Homo sapiens cDNA FU13752 fis, clone PL 48
443622 AI911527 Hs 11805 ESTs 48
442023 AI187878 Hs 144549 ESTs 47
445618 H79667 Hs 237642 Homo sapiens cDNA FU 12052 fis, clone HE 46
429611 AI889077 Hs 211388 Homo sapiens BAC clone CTB-60N22 from 7q 45
414290 AI568801 Hs 71721 ESTs 44
450715 AI266484 Hs 31570 ESTs, Weakly similar to KIAA1324 protein 44
428508 BE252383 Hs 184668 SB8I31 protein 44
425649 U30930 Hs 158540 UDP glycosyltransferase 8 (UDP-galactose 43
459247 N46243 Hs 110373 ESTs, Highly similar to T42626 secreted 43
434064 AL049045 Hs 180758 hypothetical protein PRO0082 43
414602 AW630088 Hs 76550 Homo sapiens mRNA. cONA OKFZp564B1264 (f 43
416133 NM_001683 Hs 89512 ATPase, Ca transporting plasma membrane 43
426471 M22440 Hs 170009 transforming growth factor alpha 42
409231 AA446644 Hs 692 GA733-2 andgen, epithelial glycoprotein 42
448958 AB020651 Hs 22653 KIAA0844 protein 42
410657 AF063228 Hs 65248 dynem, cytoplasmic intermediate polype 4 1
447138 AI439112 Hs 93828 ESTs, Weakly similar to 2109260A B cell 4 1
440736 D56919 Hs 265848 myomegalm 4 1
407245 X90568 Hs 172004 ddn 4 1
441976 AA428403 Hs 106131 ESTs 4 1
450642 R39773 Hs 7130 copme IV 4 1
432799 NM.016161 Hs 278960 alpha-1 4-N-acelylglucosamιnyltransferas 40
428465 AW970976 Hs 293653 ESTs 40
407868 NM.000950 Hs 40637 proline-πch Gla (G-carboxyglutamic acid 40 433558 AA833757 Hs 201769 ESTs, Weakly similar to T24435 hypothed 40
429470 AI878901 Hs 203862 guanine nucleotide binding protein (G pr 40
415666 H72693 gb yu03c11 r1 Soares fetal liver spleen 39
407988 N47760 Hs 285107 hypothedcal protein FU13397 39
427061 AB032971 Hs 173392 KIAA1145 protein 39
430261 AA305127 Hs 237225 hypothedcal protein HT023 39
440624 AF017987 Hs 7306 secreted fπzzled-related protein 1 38
431668 AW969610 Hs 151179 ESTs 38
446692 Z44514 Homo sapiens mRNA for KIAA1763 protein, 38
408739 W01556 Hs 238797 ESTs, Moderately similar to I38022 hypot 38
426716 NM 006379 Hs 171921 sema domain, immunoglobulin domain (lg) 38
450103 R08665 Hs 17244 hypothedcal protein FU13605 37
426775 AA384564 Hs 3628 ESTs 37
403469 Target Exon 37
450181 H05254 Hs 201198 ESTs 37
438202 AW169287 Hs 22588 ESTs 37
445279 R41900 Hs 22245 ESTs 37
422546 AB007969 Hs 301478 KIAA0500 protein 37
435712 AA694607 Hs 176956 ESTs 36
417620 R02530 Hs 191198 ESTs 36
421952 AA300900 Hs 98849 ESTs, Moderately similar toAF161511 1 H 36
453655 AW960427 Hs 342874 transforming growth factor, beta recepto 36
426365 AA376667 Hs 10283 RNA binding odf protein 8B 36
416982 J05401 Hs 80691 creadne kinase, mitochondπal 2 (sarcom 36
438086 AA336519 Hs 83623 nuclear receptor subfamily 1 , group I, m 36
424704 AI263293 Hs 152096 cytochrome P450, subfamily IIJ (arachido 36
414631 AW970130 Hs 65406 ESTs 36
453698 AA037615 Hs 42746 ESTs 36
438704 AI435060 Hs 32825 ESTs 35
437073 AI885608 Hs 94122 ESTs 35
434460 AA478486 Hs 3852 KIAA0368 protein 35
414541 BE293116 Hs 76392 aldehyde dehydrogenase 1 family, member 35
423665 BE167153 Hs 24380 ESTs 35
446390 AA233393 Hs 14992 hypothedcal protein FU11151 35
441264 AA927170 Hs 23290 ESTs 35
433629 R13140 Hs 13359 ESTs 35
411811 AW864370 gb PM4-SN0016-100500-004-h09 SN0016 Homo 35
410140 AL134435 Hs 247837 neurexin 3 34
415114 D60468 Hs 94181 ESTs 34
455649 BE065051 gb RC1-BT0313-110500-017-C04 BT0313 Homo 34
433670 AA604405 gb no87h09 s1 NCI CGAP AA1 Homo sapiens 34
417175 R44558 Hs 94002 ESTs 34
427176 AW381569 Hs 40334 ESTs 34
448519 AW175665 Hs 278695 Homo sapiens prostem mRNA, complete eds 34
457012 R41480 Hs 302754 ESTs 33
405354 CX000321 gι|6671579|ref|NP_031518 1| an 33
445872 AI681573 Hs 288671 Homo sapiens cDNA FU11997 fis, clone HE 33
433803 AI823593 Hs 27688 ESTs 33
449017 AW002425 Hs 224142 ESTs 33
414545 AA149287 Hs 76605 ESTs 33
409010 AI648675 Hs 103441 Homo sapiens, Similar to RIKEN cDNA 1700 33
426158 NM_001982 Hs 199067 v-erb-b2 avian erythroblastic leukemia v 33
422411 AW749443 Hs 22511 ESTs 33
428850 AA934975 Hs 185076 ESTs 33
406922 S70284 Hs 119597 gb stearoyl-CoA desaturase [human, adipo 32
429556 AW139399 Hs 98988 ESTs 32
434104 AF116691 Hs 116459 hypothedcal protein PR02198 32
427229 AI799751 Hs 5635 ESTs 32
444458 BE041526 Hs 31746 hypothedcal protein DKFZp547F072 32
433328 AW298159 Hs 23644 ESTs, Weakly similar to S65824 reverse t 32
412786 AW900654 Hs 285729 ESTs, Weakly similar to unnamed protein 32
440808 AK001339 Hs 7432 hypothedcal protein FU10477 32
442117 AW664964 Hs 128899 ESTs, hypothetical protein for IMAGE 447 3 1
429876 AB028977 Hs 225974 KIAA1054 protein 3 1
450757 BE081050 Hs 31570 ESTs, Weakly similar to KIAA1324 protein 3 1
414327 BE408145 Hs 185254 ESTs, Weakly similar to T24435 hypothed 3 1
459399 BE407712 Hs 153998 creadne kinase, mitochondrial 1 (ubiqui 3 1
433582 BE548749 Hs 148016 ESTs 3 1
452752 AW044058 Hs 33578 KIAA0820 protein 30
439165 AA029517 Hs 95162 KCNQ1 overiapping transcnpt 1 30
409403 AA668224 Hs 6634 Homo sapiens cDNA FU22547 fis, clone H 30
422414 AW875237 Hs 13701 ESTs 30
407173 T64349 gb yc10d08 s1 Stratagene lung (937210) H 30
448583 NM 015239 Hs 21542 KIAA1035 protein 30
429043 AI824977 Hs 145319 ESTs 30
452990 AA887428 Hs 246970 mitogen-activated protein kmase kinase 30
412258 AA376768 Hs 324841 hypothedcal protein FU22622 30
429968 AA322503 Hs 227011 G-substrate 30
434348 BE393191 Hs 181795 putadve b,b-carotene-9',10'-dιoxygenase 29
427115 AW972853 Hs 112237 ESTs 29
430538 AB032435 Hs 242821 differendadon-associated Na-dependeπt 29
449561 AI022240 Hs 1 924 ESTs, Moderately similar to ALU1_HUMAN A 29
405403 Target Exon 29 452197 AW023595 Hs 232048 ESTs 29
437357 AL359559 Hs 331666 Homo sapiens mRNA, cDNA DKFZp76202215 (f 29
436427 AI344378 Hs 143399 ESTs 29
417787 R1 948 Hs 23883 ESTs 29
439272 AA832474 Hs 25851 ESTs 29
454247 AJ243950 Hs 46735 deafness locus associated putadve guani 29
415839 R40611 Hs 94694 ESTs 29
408814 N62499 Hs 176227 hypothedcal protein FU 11155 29
408468 AI909712 Hs 93837 phosphaddylinositol transfer protein, m 29
431304 BE157283 gb RC4-HT0373-130200-011-a03 HT0373 Homo 29
410240 AL157424 Hs 61289 synaptojanm 2 29
444783 AK001468 Hs 62180 anillin (Drosophila Scraps homolog), act 28
408438 AB011180 Hs 100960 KIAA0608 protein 28
458793 N80159 Hs 121849 microtubule-associated proteins 1A/1B Ii 28
429788 U87791 Hs 221040 HBS1 (S cerevιsιae)-lιke 28
424264 D80400 Hs 239388 Human DNA sequence from clone RP1-304B14 28
433109 N58907 Hs 162430 EST 28
427974 BE093023 Hs 188767 ESTs 28
432266 AK000385 Hs 274222 hypothedcal protein FU20378 28
414764 AW013887 Hs 31522 ESTs 28
411918 AW876354 gb PM4-PT0019-141299-009-F08 PT0019 Homo 28
404563 Target Exon 28
446468 AI765890 Hs 16341 MAWD binding protein 28
444755 AA431791 Hs 113823 ClpX (caseiπolytic protease E coli) 28
445898 AF070623 Hs 13423 Homo sapiens clone 24468 mRNA sequence 27
427283 AL119796 Hs 174185 ectonucleodde pyrophosphatase phosphodi 27
400138 Eos Control 27
458676 AI692464 Hs 202263 ESTs 27
459697 AA406062 Hs 98002 ESTs 27
444420 AI148157 Hs 146766 ESTs 27
430371 D87466 Hs 240112 KIAA0276 protein 27
449117 AW449310 Hs 210262 ESTs, Weakly similar to HSS2_HUMAN HEPAR 27
424994 AW954525 gb EST366595 MAGE resequences, MAGC Homo 27
400339 X57131 Hs 248209 H2A histone family, member F, pseudogene 27
417494 AI369494 Hs 222137 ESTs 27
427166 AA431576 Hs 99154 ESTs 27
404746 CX000138* gι|7512767|pιr||T12477 hypothe 27
411361 AW839073 gb CM2 LT0066-O30100-109-d06 LT0066 Homo 27
428358 AA993222 Hs 101915 Stargardt disease 3 (autosomal dominant) 27
406625 Y13647 Hs 119597 stearoyl-CoA desaturase (delta-9-desatur 27
416101 R24854 Hs 268806 ESTs 27
404606 Target Exon 27
433921 AA618174 gb nq14f01 s1 NCI CGAP Thy1 Homo sapiens 27
414272 AI651603 Hs 46988 ESTs 27
418047 R37633 Hs 4847 ESTs 27
421089 AB037771 Hs 101799 KIAA1350 protein 27
412244 AW948175 gb RCO-MT0O13-28O3OO-021-C10 MT0013 Homo 27
432434 AL161977 Hs 2994 PCTAIRE protein kinase 3 26
424153 AA451737 Hs 141496 MAGE-like 2 26
427189 H82453 Hs 5635 ESTs 26
454454 AW612264 Hs 131705 ESTs 26
426747 AA535210 Hs 171995 kallikrein 3, (prostate specific andgen 26
456791 H05202 Hs 133968 FGF receptor acdvadng protein 1 26
405715 ENSP00000005198' Mixed lineage kinase ML 26
425494 N55540 Hs 78026 ESTs, Weakly similar to similar to ankyr 26
430865 AI073424 Hs 5232 HSPC125 protein 26
435767 H73505 Hs 117874 ESTs 26
410119 F07841 Hs 13926 ESTs 26
432146 AW081072 Hs 115960 KIAA0939 protein 26
448871 BE616709 Hs 159265 kruppel-related zinc finger protein hcKr 26
414516 AI307802 Hs 135560 ESTs Weakly similar to T43458 hypothed 26
429477 AI275514 Hs 6658 ESTs 26
400269 Eos Control 25
443992 AW022228 Hs 322922 ESTs 25
451926 AW134519 Hs 96125 Homo sapiens, Similar to clone FLB3816, 25
435145 AI277259 Hs 116631 ESTs 25
420309 AW043637 Hs 21766 ESTs, Weakly similar to ALU5.HUMAN ALU S 25
449709 BE410592 Hs 23918 hypothedcal protein PP5395 25
416530 U62801 Hs 79361 kallikrein 6 (neurosin, zyme) 25
411678 AI907114 Hs 71465 squalene epoxidase 25
408119 W26213 Hs 101672 ESTs, Weakly similar to T00331 hypothed 25
436624 T64297 fatty acid binding protein 1, liver 25
458268 AA428403 Hs 106131 ESTs 25
451336 AI264643 Hs 3610 ESTs 25
456924 AI631510 Hs 196956 ESTs, Highly similar to match to EST AA3 25
455040 AW852286 gb QVO-CT0225-100400-187-d08 CT0225 Homo 25
420033 D59502 Hs 292590 ESTs 25
448786 BE048842 Hs 179075 Homo sapiens cDNA FU 11881 fis, clone HE 25
432251 AW972983 Hs 232165 polycythemia rubra vera 1 , cell surface 25
408206 AF041853 Hs 43670 kinesin family member 3A 25
440205 T86950 Hs 105448 ESTs, Weakly similar to B34087 hypotheti 25
442138 AA445973 Hs 13303 Homo sapiens cDNA FU21784 fis, clone H 25
420912 AW853156 Hs 90787 ESTs 24 439180 AI393742 Hs 199067 v-erb-b2 avian erythroblastic leukemia v 24
421025 AW958975 Hs 29397 Homo sapiens cDNA FLJ 13226 fis, clone OV 24
439973 AI733308 Hs 124663 ESTs 24
446847 T51454 Hs 82845 Homo sapiens cDNA FU21930 fis, clone H 24
414672 AI218038 Hs 48504 ESTs, Moderately similar to ALU5_HUMAN A 24
451522 BE565817 Hs 26498 hypothedcal protein FU21657 24
433068 NM 006456 Hs 288215 sialyltransferase 24
446620 AA128808 Hs 179902 transporter-like protein 24
423803 NM 005709 Hs 132945 PDZ-73 protein 24
407978 AW385129 Hs 1717 phosphodiesterase 1A, calmodulm-depende 24
425907 AA365752 Hs 155965 ESTs 24
433819 AW511097 Hs 112765 ESTs 24
446066 AI343931 Hs 149383 ESTs 24
430573 AA744550 Hs 136345 ESTs 24
444992 R37658 Hs 21375 ESTs 24
434975 AA657884 Hs 314413 ESTs 24
458227 Z40670 Hs 181340 ESTs 24
443244 AI457235 Hs 166479 ESTs 24
432408 N39127 ESTs, Weakly similar to A46010 X-linked 24
401600 BE247275 US snRNP-specific protein, 116 kD 23
419066 Z98492 Hs 6975 PR01073 protein 23
424823 NM_006226 Hs 153322 phospholipase C, epsilon 23
402124 NM 031891 Homo sapiens cadheπn 20, type 23
416678 N80448 Hs 269106 ESTs 23
444897 AW137088 Hs 144857 ESTs 23
425111 BE018485 Hs 30977 ESTs, Weakly similar to B34087 hypothed 23
400536 NM.000681* Homo sapiens adrenergic, alph 23
427544 AI767152 Hs 181400 ESTs, Weakly similar to I78885 senne/th 23
459511 AI142379 gb qg64c01 r1 Soares tesds NHT Homo sap 23
415111 R39039 Hs 279041 EST 23
433331 AI738815 Hs 117323 ESTs 23
440293 AI004193 Hs 22123 ESTs 23
411770 NM 014278 Hs 71992 heat shock protein (hspl 10 family) 23
416964 D87467 Hs 80620 guanine nucleodde exchange factor for R 23
419386 AA236867 ESTs, Weakly similar to 138022 hypothed 23
402493 AI743260 mannosidase, alpha, class 1A, member 1 23
401783 NM 003771* Homo sapiens keradn, hair, a 23
420548 AA278246 Hs 920 ESTs 23
419763 AI039691 Hs 127486 ESTs 23
421750 AK000768 Hs 107872 hypothetical protein FLJ20761 23
406023 Target Exon 23
454024 AA993527 Hs 293907 hypothetical protein FU23403 23
401586 Target Exon 23
404091 Target Exon 23
456773 AI038192 Hs 129764 EGF-hke repeats and discoidin l-like do 23
414106 BE300325 Hs 77135 RNA binding protein 23
454288 BE222648 Hs 241432 ESTs, Highly similar to c380A1 1b (H sap 23
441879 AI521936 Hs 107149 novel protein similar to archaeal, yeast 23
424724 T06532 Hs 287709 Homo sapiens cDNA FU22674 fis, clone H 23
415692 N51935 Hs 47374 Homo sapiens cDNA FLJ13561 fis clone PL 23
416282 R86664 Hs 167257 brain link protem-1 22
404659 ENSP0O00O239999* HYPOTHETICAL 347 kDa P 22
429956 AI374651 Hs 22542 ESTs 22
429670 L01087 Hs 211593 protein kinase C, theta 22
429655 U48959 Hs 211582 myosin, light polypeptide kinase 22
458921 AI682088 Hs 79375 holocarboxylase synthetase (bιodn-(prop 22
436463 H06502 Hs 6656 ESTs 22
408994 AW299520 Hs 43052 ESTs 22
413303 AW836130 Hs 75277 hypothedcal protein FU13910 22
418154 BE165866 nuclear receptor subfamily 1, group I, m 22
418407 AL044818 Hs 84928 nuclear transcnpdon factor Y, beta 22
422907 AI879263 Hs 77273 Human glucose transporter pseudogene 22
446377 AW014022 Hs 170953 ESTs 22
429290 AF203032 Hs 198760 neurofilament heavy polypepdde (200kD) 22
449714 AB033015 Hs 23941 KIAA1189 protein 22
408480 AI350337 Hs 164568 fibroblast growth factor 7 (keradnocyte 22
410066 AL117664 Hs 58419 DKFZP586L2024 protein 22
410912 AW810224 gb MR4-ST0125-021199-017-e07 ST0125 Homo 22
447163 AW292770 Hs 5542 DnaJ (Hsp40) homolog, subfamily C, membe 22
421709 AA159394 Hs 107056 CED-6 protein 22
403728 Target Exon 22
453359 AA448787 Hs 24872 ESTs 22
411379 AI816344 Hs 12554 ESTs, Weakly similar to NPL4.HUMAN NUCLE 22
413427 U31120 Hs 845 intedeukin 13 22
409028 AB014513 Hs 49998 Z-band alternatively spliced PDZ-modf 22
413924 AL119964 Hs 75616 seladιn-1 22
403463 Target Exon 22
408068 AW148652 Hs 167398 ESTs 22
407819 R42185 Hs 102720 ESTs 22
414203 BE262170 Hs 78629 ATPase, Na' transporting, beta 1 polypep 22
448045 AJ297436 Hs 20166 prostate stem cell andgen 22
449835 AW979300 Hs 293813 ESTs 22
458547 AW204314 Hs 170784 ESTs 22 414276 BE297862 gb 601174780F1 NIH_MGC_17 Homo sapiens c 22
427493 H09037 Target CAT 22
458441 AW842283 Hs 288232 cyclin I 21
410705 BE004107 gb CMO-BN0102-150300-288-1128N0102 Homo 2 1
444647 H14718 Hs 11506 Human done 23589 mRNA sequence 2 1
405502 C7000609* gι|628012|pιr||A53933 myosin I 2 1
400818 Target Exon 21
435059 Z45270 Hs 235873 hypothedcal protein FU22672 21
426559 AB001914 Hs 170414 paired basic ammo acid cleaving system 2 1
445200 AA084460 Hs 12409 somatostadn 2 1
453396 AW162768 Hs 22620 ESTs 21
443819 AB033076 Hs 9873 likely homolog of rat kinase D-mteracd 2 1
401929 C17001690 gι|6005701|reflNP_009099 1| AT 2 1
451032 W03692 Hs 323079 Homo sapiens mRNA cDNA DKFZp564P116 (fr 21
433862 D86960 Hs 3610 KIAA0205 gene product 21
458694 F12832 Hs 3610 ESTs 2 1
417063 N50515 Hs 45061 ESTs 21
416935 AA190712 gb zp87f09 r 1 Stratagene HeLa cell s393 21
414446 AA147534 Hs 142019 ESTs, Weakly similar to 1207289A reverse 21
434681 AA642402 Hs 59142 ESTs 21
413835 AI272727 Hs 249163 fatty acid hydroxylase 21
426137 AL040683 Hs 167031 DKFZP566D133 protein 2 1
424481 R19453 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbac 21
454339 AW381980 gb QV4-HT0316-091199-02fW05 HT0316 Homo 2 1
407786 AA687538 Hs 38972 tetraspan 1 21
421296 NM 002666 Hs 103253 penlipin 21
444200 AA327113 Hs 149057 ESTs 21
409339 AB020686 Hs 54037 ectonucleodde pyrophosphatase/phosphodi 2 1
418410 AA811441 Hs 107393 chromosome 3 open reading frame 4 2 1
414759 AW295157 Hs 47587 ESTs 2 1
449511 AI436187 Hs 296261 guanine nucleotide binding protein (G pr 2 1
451606 AA018791 Hs 7945 AIE-75 binding protein protein 2 1
437924 AI935344 Hs 164118 ESTs, Weakly similar to SL51 HUMAN SODIU 21
449119 AI631195 Hs 232193 ESTs 2 1
431568 AW972316 Hs 283703 ESTs 2 1
447932 AA837474 Hs 20021 vesicle-associated membrane protein 1 (s 21
433516 AA595802 Hs 33410 ESTs, Weakly similar to T17279 hypotheti 2 1
441987 AW452234 Hs 128293 ESTs 2 1
414055 AW818687 Hs 5366 hypothetical protein FU21522 2 1
445066 BE178734 Hs 197422 ESTs 2 1
455546 AW994075 gb RC3-BN0036-090200-011-g06 BN0036 Homo 2 1
413607 T64741 gb yc48f11 r1 Stratagene liver (937224) 2 1
456401 W28146 gb 43f 11 Human retina cDNA randomly pπrti 20
407341 AA918886 Hs 204918 ESTs, Weakly similar to ALU8 HUMAN ALU S 20
425055 AW961959 Hs 96940 ESTs 20
426917 AA913814 Hs 172854 DKFZP586B0923 protein 20
419647 AA348947 Hs 91816 hypothedcal protein 20
412266 N59006 Hs 26133 ESTs 20
449658 AI964033 Hs 195730 ESTs, Weakly similar to CTXN RAT CORTEXI 20
424505 AA446131 Hs 124918 KIAA1795 protein 20
438219 AI916151 Hs 257194 ESTs 20
425068 AL048716 Hs 154387 KIAA0103 gene product 20
412949 AI471639 Hs 71913 ESTs 20
418866 T65754 gb yd 1c07 s1 Stratagene lung (937210) H 20
445071 AI280246 Hs 149504 ESTs 20
456529 AF014643 Hs 100072 connexιn466 20
406475 C15000508* gι|2558825|gb|AAC53387 1| (AF 20
429656 X05608 Hs 211584 neurofilament, light polypeptide (68kD) 20
431542 H63010 Hs 5740 ESTs 20
452625 AA724771 Hs 61425 ESTs 20
410378 R23324 Hs 41693 DnaJ (Hsp40) homolog, subfamily B membe 20
409767 AW501470 gb UI-HF-BP0p-a|d-b-03-0-UI r1 NIH MGC 5 20
446873 AI554439 Hs 30724 ESTs 20
453938 AF082569 Hs 36794 D-type cyclin-interacdng protein 1 20
423605 AF047826 Hs 129887 cadheππ 19 type 2 20
420061 AW024937 Hs 29410 ESTs 20
439559 AW364675 Hs 173921 ESTs, Weakly similar to 2109260A B cell 20
449901 AI674072 gb wd15h01 x1 Soares NFL T GBC.S1 Homo s 20
428304 AI743177 Hs 98422 ESTs 20
432278 AL137506 Hs 274256 hypothetical protein FLJ23563 20
458480 AI792298 p30 D8C protein 20
404559 Target Exon 20
445831 NM 006055 Hs 13351 LanC (bactenal landbiotic synthetase c 20
427523 BE242779 Hs 179526 upregulated by 1,25-dιhydroxyvιtamιn D-3 20
413055 AV655701 Hs 75183 cytochrome P450, subfamily HE (ethanol- 20
444904 AW452054 Hs 161139 ESTs 20
443713 AI082810 Hs 204934 ESTs 20
448743 AB032962 Hs 21896 KIAA1136 protein 20
428186 AW504300 Hs 295605 mannosidase, alpha, class 2A, member 2 20
448770 AA326683 Hs 21992 likely ortholog of mouse vanant polyade 20
453994 BE180964 Hs 165590 πbosomal protein S13 20
420290 AW977318 Hs 194480 ESTs 20
431467 N71831 Hs 256398 Homo sapiens mRNA, cDNA DKFZp434E0528 (f 20 447965 AW292577 Hs 94445 ESTs 20
423073 BE252922 Hs 123119 MAD (mothers against decapeπtaplegic, Dr 20
459256 AW967468 Hs 99821 hypothetical protein FU14547 20
411906 AW875765 gb QV2-PT0012-020500-186-a08 PT0012 Homo 20
441984 AB037763 Hs 8059 synaptotagmin IV 20
437900 AI763301 Hs 107331 ESTs 20
436092 AI345995 Hs 127383 ESTs 20
416529 AW009370 Hs 115772 ESTs 20
414320 U13616 Hs 75893 ankyπn 3, node of Ranvier (ankyπn G) 20
444749 AI190672 Hs 65926 ESTs 20
446277 AI284218 Hs 159204 ESTs 20
452550 AA026735 Hs 326048 Homo sapiens mRNA, cDNA DKFZp434M0420 (f 20
445725 AK000956 Hs 13209 hypothedcal protein FU10094 20
409265 T78737 Hs 321062 ESTs 20
426736 AA431615 Hs 130722 ESTs 20
447098 AI939409 Hs 157803 ESTs 20
403582 Target Exon 20
TABLE 21 B
Pkey Unique Eos probeset idendfier number
CAT number Gene duster number
Accession Genbank accession numbers
Pkey CAT Number Accession
409767 1154015.1 AW501470 AW502931 AW499500
410705 1217235.1 BE004107 BE004105 AW901093 AW797879 AW901094 AW797881 AW797880 BE004108
410912 1226543.1 AW810224 AW810337 AW810295 AW810333 AW810335 AW810296 AW816053
411361 1240611 1 AW839073 AW839234 AW839230 AW878302 AW839109 AW843897
411811 1259427.1 AW864370 AW864319 AW864504
411906 1265204.1 AW875765 H50294 AW875444
411918 1265807 1 AW876354 AW876179 AW876318 AW876290 AW876234 AW876125 AW876199 AW876198
412244 1284692.1 AW948175 AW947637 AW902869 AW947537 AW947531 AW947532 AW947530
413607 1379911.1 T64741 BE158393 BE152805
414276 1432115.-1 BE297862
415666 1543492.1 H72693 R08673 H72694 F20990 R08580
416935 163179.1 AA190712 AA190665AA252564
418154 17249.1 BE165866 BE165832 AA319621 AA401166 AI811901 H78857 X56199 R93797 AW896675 AA401072 AW374411 H52942 AW896685 AA348138
AI399764 AA010244 W90159 N90874 AA339496 AW967136 W38705 AA029093 AW444647 BE175700 AV651656 AV651847 AA332039 AV649227
AV649164 AV649491 N87956 AA332262 BE001561 H75493 BE218742 AA333298 AA095633 AA091968 M78602 T05342 W17094 AA126501
AW374665 AI452905 AW316900 AI185080 AI202928 AI651843 AA693541 AI681019 AV658257 AV658133 BE045335 BE089546 AA300830 AA361376
BE218739 AW207622 AA765340 AW612733 BE348741 AI806054 AI871563 AA808652 AI500693 AW342032 AA147066
418866 179788.1 T65754 AA229857 AA229658 419386 184356.1 AA236867 AA237066 AA354236 AW957759 H08961 424994 245786.1 AW954525 AI372685 AA349501 AI372687 H10564 427493 279541.2 H09037 AW974937 AA657521 H86138 H86513 H09016 AA404410 AA404454 431304 331286.1 BE157283 BE157287 AA502438 432408 346286.2 N39127 F20776 AI082691 AA865520 F36964 F33894 433670 372721.1 AA604405 BE062234 AW748386 433921 377350.1 AA618174 AI114549 R36464 R36465 436624 4237.5 T64297 AA894931 NM.001443 M10050 AW843109 AI698516 T53219 T48785 T64166 AA706930 R29613 T55913 T56518 T64679 R29666 M10617
AI768596 AA101894 W90338 AI742193 AW752206 AA099433 T53220 AW082135 AW272775 T29562 T55862 AI343047 AI345671 T68235 T68121
AW842284
446692 689623.1 Z44514 AI352097 AI803984 AW235923ΑW196558 AI954637 AI336983 449901 818599 1 AI674072 BE268487 454339 1122972.1 AW381980 BE152244 BE152235 BE152238 BE152232 455040 1250028.1 AW852286 AW851934 AW852096 AW852274 455546 1324614.1 AW994075 AW994386 455649 1348708 1 BE065051 BE155165 BE064764 BE155231 BE064648 BE064671 BE064636 456401 1844649.2 W28146 W28187 458480 59843 1 AI792298 H14121 AI375113 AA960851 AA744592AV648739AI298360 AW293609
TABLE 21C
Pkey Unique number conesponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham, et al " refers to the publicadon endded "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted Nt.position Indicates nucleotide positions of predicted exons
Pkey Ref Strand Nt position
400536 9797380 Minus 170994-172025
400818 8569994 Plus 172644-172765,173085-173200
401586 9838242 Minus 93974-94099
401600 4388746 Minus 27363-27518,28727-28891,29526-29731
401783 7249190 Plus 139369-139827,140509-140591,140834-140990,141496-141657,141757-141882,142063-142283
401929 3810670 Minus 3167-3286,4216-4310
402124 4033680 Plus 164206-164459
402493 9797670 Minus 205146-205240,205428-205542
403463 9929538 Plus 102596-102879
403469 9929739 Minus 4831-7707
403582 8101186 Plus 18308-18458
403728 7534291 Minus 34481-34671
404091 7684554 Minus 82121-83229
404559 8748893 Minus 73499-73651,89575-89739 404563 9838310 Plus 100136-100343
404606 9212936 Minus 22310-23269
404659 9797068 Minus 65026-67930
404746 7219894 Minus 32643-32834
405354 2642452 Plus 52213-53089
405403 6850244 Minus 37491-37670,40951-41031
405502 9211311 Minus 50360-50584
405715 4156209 Plus 26293-26706
406023 8272661 Plus 205623-205936
406475 9797684 Plus 125417-125563,128052-128180
TABLE 22A ABOUT 301 GENES SIGNIFICANTLY DOWN-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS
Table 22A lists about 301 genes significanϋy down-regulated in glioblastoma compared to normal adult CNS dssues These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the rado of "average* normal CNS to "average" glioblastoma was greater than or equal to 2 The "average" noimal CNS level was set to the 75* percendle amongst vaπous normal CNS dssues The "average" glioblastoma level was set to the 95* percendle amongst vanous tumor samples In order to remove gene- specific background levels of non-specific hybndizadon, the 10* percendle value amongst various non-malignant dssues was subtracted from both the numerator and the denominator before the rado was evaluated
Pkey Unique Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigε me number
Unigene Title Unigene gene dtle
R1 Rado of CNS to GLIOBLASTOMA
Pkey ExAccn UnigenelD Unigene Tide R1
418318 U47732 Hs 84072 transmembrane 4 superfamily member 3 10 1
445529 H14421 Hs 180513 ATP-bindmg cassette, sub-family A (ABC1 94
415274 AF001548 Hs 78344 myosin, heavy polypeptide 11, smooth mus 75
417167 AW206437 Hs 4290 ESTs 73
453165 S74727 Hs 32042 aspartoacylase (aminoacylase 2, Canavan 65
454076 AW204712 Hs 61957 ESTs 63
417275 X63578 Hs 295449 parvalbumin 62
412636 NM 004415 desmoplakin (DPI, DPII) 60
409743 N48721 Hs 183506 hypothedcal protein FU14213 59
424645 NM 014682 Hs 151449 KIAA0535 gene product 56
427322 AK002017 Hs 176227 hypothetical protein FU11155 55
446390 AA233393 Hs 14992 hypothedcal protein FU 11151 52
444409 AI792140 Hs 49265 ESTs 52
409031 AA376836 Hs 288856 ESTs 51
408428 NM 014787 Hs 44896 DnaJ (Hsp40) homolog, subfamily B, membe 48
428414 AL049980 Hs 184216 DKFZP564C152 protein 48
428874 W32133 Hs 194366 traπsthyredn (prealbumin, amyloidosis t 46
420605 BE391491 Hs 99291 HSPC156 protein 46
445618 H79667 Hs 237642 Homo sapiens cDNA FU12052 fis, clone HE 46
450715 AI266484 Hs 31570 ESTs, Weakly similar to KIAA1324 protein 44
428508 BE252383 Hs 184668 SBBI31 protein 44
434064 AL049045 Hs 180758 hypothetical protein PRO0082 43
410330 AW023630 Hs 159425 ESTs 42
426471 M22440 Hs 170009 transforming growth factor, alpha 42
409231 AA446644 Hs 692 GA733-2 antigen, epithelial glycoprotein 42
448958 AB020651 Hs 22653 KIAA0844 protein 42
428465 AW970976 Hs 293653 ESTs 40
429470 AI878901 Hs 203862 guanine nucleotide binding protein (G pr 40
432298 AL118812 Hs 274293 Homo sapiens mRNA, cDNA DKFZp761G1111 (f 39
427061 AB032971 Hs 173392 KIAA1145 protein 39
430261 AA305127 Hs 237225 hypothedcal protein HT023 39
435145 AI277259 Hs 116631 ESTs 38
416101 R24854 Hs 268806 ESTs 38
426716 NM 006379 Hs 171921 sema domain, immunoglobulin domain (lg), 38
438202 AW1692S7 Hs 22588 ESTs 38
433558 AA833757 Hs 201769 ESTs, Weakly similar to T24435 hypotheti 37
419956 AL137939 Hs 40096 ESTs 37
430573 AA744550 Hs 136345 ESTs 37
422546 AB007969 Hs 301478 KIAA0500 protein 37
453344 BE349075 Hs 44571 ESTs 36
417620 R02530 Hs 191198 ESTs 36
421952 AA300900 Hs 98849 ESTs, Moderately similar to AF161511 1 H 36
414631 AW970130 Hs 65406 ESTs 36
437073 AI885608 Hs 94122 ESTs 35
441264 AA927170 Hs 23290 ESTs 35
433629 R13140 Hs 13359 ESTs 35
415114 D60468 Hs 94181 ESTs 34
411770 NM 014278 Hs 71992 heat shock protein (hspl 10 family) 34
415666 H72693 gb yu03c11 rl Soares fetal liver spleen 34
416851 AW963951 Hs 85618 ESTs 34
443037 AW500305 Hs 8906 syntaxin 7 34
449511 AI436187 Hs 296261 guanine nucleotide binding protein (G pr 34
427176 AW381569 Hs 40334 ESTs 34
438704 AI435060 Hs 32825 ESTs 33
417175 R44558 Hs 94002 ESTs 33
430865 AI073424 Hs 5232 HSPC125 protein 33
457012 R41480 Hs 302754 ESTs 33
405354 CX00O321 gι|6671579|reflNP.031518 1| an 33
432799 NM.016161 Hs 278960 alpha- 1 ,4-N-acetylglucosamιnyltransferas 33 429876 AB028977 Hs 225974 KIAA1054 protein 33
434348 BE393191 Hs 181795 putative b.b-carotene-ΘMO'-dioxygenase 33
441071 D79550 Hs 149 Homo sapiens cDNA FU21950 fis, clone H 33
445279 R41900 Hs 22245 ESTs 32
414541 BE293116 Hs 76392 aldehyde dehydrogenase 1 family, member 32
448072 AI459306 Hs 24908 ESTs 32
402429 Target Exon 32
433328 AW298159 Hs 23644 ESTs, Weakly similar to S65824 reverse 1 32
400138 Eos Control 31
414327 BE408145 Hs 185254 ESTs, Weakly similar to T24435 hypothed 3 1
459399 BE407712 Hs 153998 creadne kinase, mitochondrial 1 (ubiqui 31
433582 BE548749 Hs 148016 ESTs 31
434104 AF116691 Hs 116459 hypothedcal protein PR02198 30
404606 Target Exon 30
407173 T64349 gb yc10d08 s1 Stratagene lung (937210) H 30
415672 N53097 Hs 193579 ESTs 30
448583 NM 015239 Hs 21542 KIAA1035 protein 30
429043 AI824977 Hs 145319 ESTs 30
439165 AA029517 Hs 95162 KCNQ1 overlapping transcπpt 1 29
449561 AI022240 Hs 17924 ESTs, Moderately similar to ALU1 HUMAN A 29
436427 AI344378 Hs 143399 ESTs 29
405403 Target Exon 29
452197 AW023595 Hs 232048 ESTs 29
437357 AL359559 Hs 331666 Homo sapiens mRNA cDNA DKFZp76202215 (f 29
439272 AA832474 Hs 25851 ESTs 29
415839 R40611 Hs 94694 ESTs 29
411906 AW875765 gb QV2-PT0012-020500-186-a08 PT0012 Homo 29
409403 AA668224 Hs 6634 Homo sapiens cDNA FU22547 fis, clone H 29
412258 AA376768 Hs 324841 hypothedcal protein FU22622 28
435836 AW292532 Hs 343667 homolog of yeast long chain polyuπsatura 28
433109 N58907 Hs 162430 EST 28
404563 Target Exon 28
427974 BE093023 Hs 188767 ESTs 28
413324 V00571 Hs 75294 corticotropin releasing hormone 27
409263 AA069573 Hs 50319 ESTs 27
454247 AJ243950 Hs 46735 deafness locus associated putadve guani 27
449180 AI633836 Hs 195649 ESTs 27
416004 D11880 Hs 299254 Homo sapiens cDNA FU23597 fis clone L 27
424994 AW954525 gb EST366595 MAGE resequences, MAGC Homo 27
430371 D87466 Hs 240112 KIAA0276 protein 27
449117 AW449310 Hs 210262 ESTs, Weakly similar to HSS2 HUMAN HEPAR 27
451007 H38108 Hs 32759 ESTs 27
414502 AL133721 Hs 224680 ESTs 27
458793 N80159 Hs 121849 microtubule-associated proteins 1A/1B Ii 27
459053 AI807052 Hs 210361 ESTs 27
427229 AI799751 Hs 5635 ESTs 27
425649 U30930 Hs 158540 UDP glycosyltransferase 8 (UDP-galactose 27
444922 AI921750 Hs 144871 Homo sapiens cDNA FU13752 fis, clone PL 27
433921 AA618174 gb nq14f01 s1 NCI CGAP Thy1 Homo sapiens 27
414272 AI651603 Hs 46988 ESTs 27
418047 R37633 Hs 4847 ESTs 27
421089 AB037771 Hs 101799 KIAA1350 protein 27
416498 U33632 Hs 79351 potassium channel, subfamily K, member 1 26
414290 AI568801 Hs 71721 ESTs 26
433703 AA210863 Hs 3532 nemo-like kinase 26
408739 W01556 Hs 238797 ESTs, Moderately similar to I38022 hypot 26
414602 AW630088 Hs 76550 Homo sapiens mRNA, cDNA DKFZp564B1264 (f 26
422137 AJ236885 Hs 112180 zinc finger protein 148 (pHZ-52) 26
442023 AI187878 Hs 144549 ESTs 26
421709 AA159394 Hs 107056 CED-6 protein 26
426747 AA535210 Hs 171995 kallikrein 3, (prostate specific andgen 26
412244 AW948175 gb RCO-MT0013-280300-021-C10 MT0013 Homo 26
419386 AA236867 ESTs, Weakly similar to I38022 hypothed 26
423665 BE167153 Hs 24380 ESTs 26
430320 BE245290 Hs 239218 uncharacteπzed hypothalamus protein HCD 26
408468 AI909712 Hs 93837 phosphahdylinositol transfer protein, m 26
410657 AF063228 Hs 65248 dynem, cytoplasmic, intermediate polype 26
448871 BE616709 Hs 159265 kruppel-related zinc finger protein hcKr 26
414516 AI307802 Hs 135560 ESTs, Weakly similar to T43458 hypothed 26
459080 AW192083 Hs 290855 ESTs 25
455040 AW852286 gb QVO-CT0225-100400-187-d08 CT0225 Homo 25
435712 AA694607 Hs 176956 ESTs 25
431662 AA513406 Hs 152307 ESTs 25
435902 AA701867 Hs 297726 ESTs 25
436624 T64297 fatty acid binding protein 1, liver 25
443155 R54485 Hs 23772 ESTs 25
439183 AW970600 Hs 303261 ESTs 25
426365 AA376667 Hs 10283 RNA binding modf protein 88 25
420033 D59502 Hs 292590 ESTs 25
408438 AB011180 Hs 100960 KIAA0608 protein 25
440205 T86950 Hs 105448 ESTs, Weakly similar to B34087 hypothed 25
448786 BE048842 Hs 179075 Homo sapiens cDNA FU11881 fis, clone HE 25
432251 AW972983 Hs 232165 polycythemia rubra vera 1, cell surface 25 427115 AW972853 Hs 112237 ESTs 24
433670 AA604405 gb no87h09 s1 NO CGAP AA1 Homo sapiens 24
452022 AW072330 Hs 293875 ESTs 24
408814 N62499 Hs 176227 hypothetical protein FU 11155 24
403469 Target Exon 24
450374 AA397540 Hs 60293 Homo sapiens clone 122482 unknown mRNA 24
451926 AW134519 Hs 96125 Homo sapiens, Similar to clone FLB3816, 24
443622 AI911527 Hs 11805 ESTs 24
456791 H05202 Hs 133968 FGF receptor acdvadng protein 1 24
414672 AI218038 Hs 48504 ESTs Moderately similar to ALU5_HUMAN A 24
451522 BE565817 Hs 26498 hypothetical protein FU21657 24
422414 AW875237 Hs 13701 ESTs 24
425383 D83407 Hs 156007 Down syndrome cπdcal region gene 1-lιk 24
438086 AA336519 Hs 83623 nuclear receptor subfamily 1 , group 1, m 24
410240 AL157424 Hs 61289 synaptoianin 2 24
432408 N39127 ESTs, Weakly similar to A46010 X-linked 24
458227 Z40670 Hs 181340 ESTs 24
431325 AW026751 Hs 5794 ESTs, Weakly similar to 2109260A B cell 24
401600 BE247275 U5 snRNP-specific protein, 116 kD 23
422963 M79141 Hs 13234 ESTs 23
444897 AW137088 Hs 144857 ESTs 23
418207 C14685 Hs 34772 ESTs 23
445071 AI280246 Hs 149504 ESTs 23
407868 NM 000950 Hs 40637 proline-πch Gla (G-carboxyglutamic acid 23
433331 AI738815 Hs 117323 ESTs 23
440293 AI004193 Hs 22123 ESTs 23
428850 AA934975 Hs 185076 ESTs 23
401783 NM 003771* Homo sapiens keradn, hair, a 23
419763 AI039691 Hs 127486 ESTs 23
416018 AW138239 Hs 78977 proprotein convertase subtilisin/kexin t 23
420912 AW853156 Hs 90787 ESTs 23
442097 AW015799 Hs 128474 ESTs 23
425907 AA365752 Hs 155965 ESTs 23
404091 Target Exon 23
414106 BE300325 Hs 77135 RNA binding protein 23
454288 BE222648 Hs 241432 ESTs, Highly similar to c380A1 1b [H sap 23
441040 AW449782 Hs 178803 ESTs 23
424724 T06532 Hs 287709 Homo sapiens cDNA FU22674 fis, clone H 23
441879 AI521936 Hs 107149 novel protein similar to archaeal, yeast 23
407988 N47760 Hs 285107 hypothetical protein FU13397 22
452420 BE564871 Hs 29463 centπn EF-hand protein, 3 (CDC31 yeast 22
458676 AI692464 Hs 202263 ESTs 22
418407 AL044818 Hs 84928 nuclear transcnpdon factor Y, beta 22
453938 AF082569 Hs 36794 D-type cyclin-interacting protein 1 22
407978 AW385129 Hs 41717 phosphodiesterase 1A, calmodulin-depende 22
420548 AA278246 Hs 920 ESTs 22
422907 AI879263 Hs 77273 Human glucose transporter pseudogene 22
446351 AW444551 Hs 35380 x 001 protein 22
442117 AW664964 Hs 128899 ESTs, hypothetical protein for IMAGE 447 22
429598 AA811257 Hs 269710 ESTs 22
408480 AI350337 Hs 164568 fibroblast growth factor 7 (keradnocyte 22
411361 AW839073 gb CM2 LT0066-O3O10O-1OMO6 LT0066 Homo 22
459697 AA406062 Hs 98002 ESTs 22
409856 AW502082 gb UI-HF-BROp-ajq-g-04-O-UI r1 NIH MGC 5 22
444760 AI796296 Hs 208062 ESTs 22
443258 AF169301 Hs 9098 sulfate transporter 1 22
428206 AB020643 Hs 183006 KIAA0836 protein 22
410119 F07841 Hs 13926 ESTs 22
413427 U31120 Hs 845 interieukin 13 22
438021 AV653790 Hs 324275 WW domain-containing protein 1 22
428652 AA584272 Hs 336224 transmembrane protein with EGF-like and 22
429655 U48959 Hs 211582 myosin, light polypeptide kinase 22
424153 AA451737 Hs 141496 MAGE-dke 2 22
413303 AW836130 Hs 75277 hypothedcal protein FU13910 22
427287 NM 014903 Hs 174188 KIAA0938 protein 22
449658 AI964033 Hs 195730 ESTs, Weakly similar to CTXN RAT CORTEXI 22
441984 AB037763 Hs 8059 synaptotagmin IV 22
449709 BE410592 Hs 23918 hypothetical protein PP5395 22
408068 AW148652 Hs 167398 ESTs 22
407819 R42185 Hs 102720 ESTs 22
414203 BE262170 Hs 78629 ATPase, Na9 transporting, beta 1 polypep 22
454339 AW381980 gb QV4-HT0316-091199-028005 HT0316 Homo 22
448045 AJ297436 Hs 20166 prostate stem cell andgen 22
458480 AI792298 p30 DBC protein 22
449835 AW979300 Hs 293813 ESTs 22
458547 AW204314 Hs 170784 ESTs 22
411678 AI907114 Hs 71465 squalene epoxidase 2 1
444783 AK001468 Hs 62180 anillin (Drosophila Scraps homolog), act 21
424632 AB014523 Hs 151406 KIAA0623 gene product 2 1
449901 AI674072 gb wd15h01 x1 Soares_NFL_T_GBC.S1 Homo s 2 1
431583 AL042613 Hs 262476 S-adenosylmethionine decarboxylase 1 2 1
410538 AW753115 gb PM0-CT0248-131099-001-h12 CT0248 Homo 2 1
426775 AA384564 Hs 3628 ESTs 2 1 433862 D86960 Hs 3610 KIAA0205 gene product 2 1
458694 F12832 Hs 3610 ESTs 2 1
417063 N50515 Hs 45061 ESTs 2 1
416935 AA190712 gb zp87f09 r1 Stratagene HeLa cell s393 21
436489 AJ272269 Hs 121429 zinc-binding protein Rbcc728 2 1
431128 AI203545 Hs 296169 S-phase response (cydin-related) 2 1
442310 AF033199 Hs 8198 zinc finger protein 204 2 1
432434 AL161977 Hs 2994 PCTAIRE protein kinase 3 21
400339 X57131 Hs 248209 H2A histone family, member F, pseudogene 2 1
432266 AK000385 Hs 274222 hypothedcal protein FLJ20378 2 1
414759 AW295157 Hs 47587 ESTs 21
438219 AI916151 Hs 257194 ESTs 2 1
451336 AI264643 Hs 3610 ESTs 2 1
430538 AB032435 Hs 242821 differendation-associated Na-dependent 2 1
413493 BE144444 gb MR0-HT0168-141199-002-f09 HT0168 Homo 21
428501 AL041162 Hs 98587 ESTs 21
431568 AW972316 Hs 283703 ESTs 21
456177 NM 012391 Hs 79414 prostate epithelium-specific Ets franscr 2 1
441976 AA428403 Hs 106131 ESTs 2 1
421311 N71848 Hs 283609 hypothedcal protein PRO2032 21
428358 AA993222 Hs 101915 Staigardt disease 3 (autosomal dominant) 2 1
439973 AI733308 Hs 124663 ESTs 2 1
446185 AI279191 Hs 149454 ESTs, Weakly similar to DSR6.HUMAN DOWN 21
451606 AA018791 Hs 7945 AIE-75 binding protein protein 21
433516 AA595802 Hs 33410 ESTs. Weakly similar to T17279 hypothed 2 1
441987 AW452234 Hs 128293 ESTs 2 1
457140 AI279960 Hs 178140 ESTs 21
414055 AW818687 Hs 5366 hypothedcal protein FU21522 2 1
445066 BE178734 Hs 197422 ESTs 2 1
459265 AJ003616 gb AJ003616 Selected chromosome 21 cDNA 20
425337 AA355442 Hs 169054 ESTs 20
409339 AB020686 Hs 54037 ectoπucleodde pyrophosphatase/phosphodi 20
453023 AW028733 Hs 31439 senne protease inhibitor, Kunitz type, 20
425055 AW961959 Hs 96940 ESTs 20
425068 AL048716 Hs 154387 KIAA0103 gene product 20
444700 NM 003645 Hs 11729 fatty acid-Coenzyme A ligase very loπg- 20
424823 NM 006226 Hs 153322 phosphodpase C, epsilon 20
450103 R08665 Hs 17244 hypothedcal protein FU 13605 20
448519 AW175665 Hs 278695 Homo sapiens prostein mRNA, complete eds 20
440808 AK001339 Hs 7432 hypothedcal protein FU10477 20
429968 AA322503 Hs 227011 G-substrate 20
429290 AF203032 Hs 198760 neurofilament, heavy polypeptide (200kD) 20
433068 NM 006456 Hs 288215 sialyltransferase 20
416982 J05401 Hs 80691 creadne kinase, mitochondnal 2 (sarcom 20
423479 NM 014326 Hs 129208 death-associated protein kinase 2 20
407341 AA918886 Hs 204918 ESTs, Weakly similar to ALU8 HUMAN ALU S 20
452625 AA724771 Hs 61425 ESTs 20
410378 R23324 Hs 41693 DnaJ (Hsp40) homolog, subfamily B, merttbe 20
409767 AW501470 gb UI-HF-BPOp-ajd-b-03-O-UI r1 NIH_MGC_5 20
415925 H09474 Hs 202341 Homo sapiens cDNA FU23573 fis, clone L 20
405670 C2000627* gι|12034653|gb|AAG45951 1|AF22 20
408206 AF041853 Hs 43670 kinesin family member 3A 20
458660 AI299739 Hs 99601 hypothedcal protein FU 12553 20
432278 AL137506 Hs 274256 hypothedcal protein FU23563 20
404559 Target Exon 20
403728 Target Exon 20
413055 AV655701 Hs 75183 cytochrome P450, subfamily HE (ethanol- 20
407786 AA687538 Hs 38972 tetraspan 1 20
413266 BE300352 gb 600944231F1 NIH.MGC.17 Homo sapiens c 20
453994 BE180964 Hs 165590 πbosomal protein S13 20
451583 AI653797 Hs 24133 ESTs 20
443244 AI457235 Hs 166479 ESTs 20
453396 AW162768 Hs 22620 ESTs 20
415694 AW194301 Hs 339283 Human DNA sequence from clone RP1-187J11 20
459511 AI142379 gb qg64c01 r1 Soares esds.NHT Homo sap 20
450757 BE081050 Hs 31570' ESTs, Weakly similar to KIAA1324 protein 20
451032 W03692 Hs 323079 Homo sapiens mRNA cDNA DKFZp564P116 (fr 20
440509 BE410132 Hs 134202 ESTs, Weakly similar to T17279 hypotheti 20
444647 H14718 Hs 11506 Human clone 23589 mRNA sequence 20
447932 AA837474 Hs 20021 vesicle-associated membrane protein 1 (s 20
444749 AI190672 Hs 65926 ESTs 20
446277 AI284218 Hs 159204 ESTs 20
452550 AA026735 Hs 326048 Homo sapiens mRNA, cDNA DKFZp434M0420 (f 20
453843 D25215 Hs 35804 hect domain and RLD 3 20
445725 AK000956 Hs 13209 hypothetical protein FLJ 10094 20
409265 T78737 Hs 321062 ESTs 20
TABLE 22B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession 409767 1154015J AW501470 AW502931 AW499500 409856 1156268 AW502082 AW502979 AW502807 AW501876 410538 1207341.1 AW753115 AW753113 R45779 411361 1240611.1 AW839073 AW839234 AW839230 AW878302 AW839109 AW843897 411906 1265204.1 AW875765 H50294 AW875444 412244 1284692 1 AW948175 AW947637 AW902869 AW947537 AW947531 AW947532 AW947530 412636 13165 1 NM.004415AL031058 M77830 BE149760AW752599AW848723AW376697AW376817 AW376699AW848371 AW376782AW848789AW361413
AW849074 AW997139 AW799304 AW799309 BE077020 BE077017 BE185187 AW997196 BE156621 BE179915 BE006561 BE143155 AW890985
BE002107 AW103521 AA857316AW383133 BE011378AW170253 BE185750AW886475 BE160433J05211 BE082576BE082584 BE004047
AW607238 AW377700 AW377699 BE082526 BEO82505 BE082507 BE082514 AW178000 AW177933AI905935 AW747877 AW748114 BE148516
AW265328 AW847678 AW847688 AW365151 AW365148 AW365153 AW365156 AW365175 AW365157 AW365154 AW068840 BE005272 AW365145
BE001925 BE182166 BE144243 BE0O1923 AI951766 AI434518 BE1849208E184933 AI284090 BE184941 AW804674 BE184924 C04715 W39488
AW995615 BE184948 BE159646AW606653AA099891 AA131128AA337270AA340777AW384371 AA852212 R58704AW366566AW364859
AA025851 AA025852 AA455100 AA719958 AW352220 AW996245 BE165351 BE073467 AA377127 AW890264 AW609750 AW391912 AW849690
T87267 AW853812 AA852213W74149 BE009090AA056401 H91011 AW368529AW390272 C18467AW674920 N57176AA026480AW576767
H93284 AA026863 AW177787 AA026654 AW177786 BE092134 BE092137 BE092136 AW177784 AI022862 BE091653 AW376811 AW848592
AA040018 BE185331 BE182164 AA368564 AW951576T29918 AA131077 W95048 W25458 AW205789 H90899 N29754 W32490 R20904 BE167181
BE167165 N84767 H27408 H30146 AI190590 C03378 AI554403 AI205263 AA128470 AI392926 AF139065 AW370813 AW370827 AW798417
AW798780 AW798883 AW798569 R33557 AA149190 C03029 AW177783 AA088866 AW370829 AA247685 BE002273 AI760816 AI439101 AW879451
AI700963 AA451923 AI340326 AI590975 T48793 AI568096 AI142882 AA039975 AI470146 AA946936 BE067737 BE067786 W19287 AA644381
AA702424 AI417612 AI306554 AI686869 AI568892 AW190555 AI571075 AI220573 AA056527 AI471874 AI304772 AW517828 AI915596 AI627383
AI270345 AW021347 AW166807 AW105614 AI346078 AA552300 W95070 AI494069 AI911702 AA149191 AA026864 AI830049 AI887258 AW780435
AI910434 AI819984 AI858282 AI078449 AI025932 AI860584 AI635878 AA026047 AA703232 D12062 AW192085 AA658154 AW514597 AW591892
T87181 AA782066 AW243815 AW150038 AW268383 AW004633 AI927207 AA782109 AW473233 AI804485 AW169216 AI572669 AA602182
AW015480 AW771865 AI270027 AA961816 AA283207 AI076962 AI498487 AI348053 AI783914 H44405 AW799118 AA128330 AA515500 AA918281
W02156 AI905927 AA022701 W38382 R20795 T77861 AW860878
413266 1356260.1 BE300352 BE299274 BE075351 BE297444 413493 1373555.1 BE144444BE144430 415666 1543492.1 H72693 R08673 H72694 F20990 R08580 416935 163179.1 AA190712 AA190665 AA252564 419386 184356.1 AA236867 AA237066 AA354236 AW957759 H08961 424994 245786.1 AW954525 AI372685 AA349501 AI372687 H10564 432408 346286.2 N39127 F20776 AI082691 AA865520 F36964 F33894 433670 372721.1 AA604405 BE062234 AW748386 433921 377350.1 AA618174 Al 114549 R36464 R36465 436624 4237.5 T64297 AA894931 NM_001443 M10050 AW843109 AI698516 T53219 T48785 T64166 AA706930 R29613T55913 T56518 T64679 R29666 M10617
AI768596 AA101894 W90338 AI742193 AW752206 AA099433 T53220 AW082135 AW272775 T29562 T55862 AI343047 AI345671 T68235 T68121
AW842284
449901 818599.1 AI674072 BE268487 454339 1122972.1 AW381980 BE152244 BE152235 BE152238 BE152232 455040 1250028.1 AW852286 AW851934 AW852096 AW852274 458480 59843.1 AI792298 H14121 AI375113 AA960851 AA744592 AV648739 AI298360 AW293609 459265 966590 1 AJ003616 AJ003654 AJ003617
TABLE 22C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham, et al * refers to the publicadon entitled 'The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons
Pkey Ref Strand NLposition
401600 4388746 Minus 27363-2751828727-28891,29526-29731
401783 7249190 Plus 139369-139827,140509-140591,140834-140990,141496-141657,141757-141882,142063-142283
402429 9796372 Minus 57622-57793,59282-59402,59624-59827
403469 9929739 Minus 4831-7707
403728 7534291 Minus 34481-34671
404091 7684554 Minus 82121-83229
404559 8748893 Minus 73499-73651,89575-89739
404563 9838310 Plus 100136-100343
404606 9212936 Minus 22310-23269
405354 2642452 Plus 52213-53089
405403 6850244 Minus 37491-37670,40951-41031
405670 4662655 Plus 96543-96870
TABLE 23A ABOUT 441 GENES SIGNIFICANTLY DOWN-REGULATED IN LOWER GRADE GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS
Table 23A lists about 441 genes significantly down-regulated in lower grade glioblastoma (LGG) compared to normal adult CNS tissues These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the rado of "average* normal CNS to "average* LGG was greater than or equal to 25 The "average* normal CNS level was set to the 75* percentile amongst various normal CNS tissues The 'average* LGG level was set to the 95* percendle amongst vanous tumor samples In order to remove gene-specific background levels of non-specific hybndization, the 10* percentile value amongst vaπous non-malignant tissues was subtracted from both the numerator and the denominator before the rado was evaluated
Pkey Unique Eos probeset identifier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dtle
R1 Rado of CNS to LOWER GRADE GLIOBLASTOMA Pkey ExAccn UnigenelD Unigene Tide R1 415388 AF018081 Hs 78409 collagen, type XVIII, alpha 1 103
418318 U47732 Hs 84072 transmembrane 4 superfamily member 3 10 1
445529 H14421 Hs 180513 ATP-bindmg cassette, sub-family A (ABC1 99
417433 8E270266 Hs 82128 5T4 oncofetal trophoblast glycoprotein 78 422746 NM 004484 Hs 119651 glypican 3 77
448362 AA641767 Hs 21015 hypothedcal protein DKFZp564L0864 simil 77
430573 AA744550 Hs 136345 ESTs 76
415274 AF001548 Hs 78344 myosin, heavy polypeptide 11, smooth mus 75
419290 AI128114 Hs 112885 spinal cord-deπved growth factor-B 74
424670 W61215 Hs 116651 epithelial V-like antigen 1 73
417167 AW206437 Hs 4290 ESTs 73
416018 AW138239 Hs 78977 proprotein convertase subdlisin/kexm t 73
424632 AB014523 Hs 151406 KIAA0623 gene product 69
453165 S74727 Hs 32042 aspartoacylase (ammoacylase 2, Canavan 65
411770 NM 014278 Hs 71992 heat shock protein (hspl 10 family) 65
439272 AA832474 Hs 25851 ESTs 65
414831 M31158 Hs 77439 protein kinase, cAMP-dependent regulato 64
454076 AW204712 Hs 61957 ESTs 63
446390 AA233393 Hs 14992 hypothedcal protein FU11151 63
430865 AI073424 Hs 5232 HSPC125 protein 63
434064 AL049045 Hs 180758 hypothedcal protein PRO0082 62
417458 NM.005655 Hs 82173 TGFB inducible early growth response 6 1
412636 NM 004415 desmoplakin (DPI, DPII) 60
409743 N48721 Hs 183506 hypothetical protein FU14213 59
430998 AF128847 Hs 204038 indolethylamine N-methyltransferase 58
434725 AK000796 Hs 4104 hypothedcal protein 56
417175 R44558 Hs 94002 ESTs 56
417275 X63578 Hs 295449 parvalbumin 55
427322 AK002017 Hs 176227 hypothetical protein FU11155 55
431009 BE149762 Hs 48956 gap junction protein, beta 6 (connexiπ 3 54
420297 AI628272 Hs 88323 ESTs, Weakly similar to ALU1 HUMAN ALU S 54
412472 AW975398 Hs 293836 ESTs 54
443258 AF169301 Hs 9098 sulfate transporter 1 53
427210 BE396283 Hs 173987 eukaryodc translation inidadon factor 53
442064 AI422867 Hs 88594 ESTs 52
438868 AW246243 Hs 334800 hypothedcal protein FU20974 52
444409 AI792140 Hs 49265 ESTs 52
442310 AF033199 Hs 8198 zinc finger protein 204 5 1
409031 AA376836 Hs 288856 ESTs 5 1
438460 AB020702 Hs 6224 KIAA0895 protein 51
411939 AI365585 Hs 146246 ESTs 50
448429 D17408 Hs 21223 calponin 1, basic, smooth muscle 50
413293 AL047483 Hs 302498 GTP-binding protein homologous to Saccha 50
408968 AI652236 Hs 49376 hypothetical protein FU20644 50
443491 AW499665 Hs 9456 SWI/SNF related, matrix associated acd 49
448960 AF006513 Hs 22670 chromodomam helicase DNA binding protei 49
416101 R24854 Hs 268806 ESTs 49
433558 AA833757 Hs 201769 ESTs, Weakly similar to T24435 hypothed 49
424645 NM 014682 Hs 151449 KIAA0535 gene product 48
437679 NM.014214 Hs 5753 ιnosιtol(myo)-1(or 4)-monophosphatase 2 48
408428 NM 014787 Hs 44896 DnaJ (Hsp40) homolog, subfamily B, membe 48
414502 AL133721 Hs 224680 ESTs 48
442572 AI001922 Hs 135121 hypothetical protein FU22415 48
412700 BE222433 Hs 239208 ESTs, Weakly similar to I38022 hypothed 48
422603 BE242587 Hs 118651 hematopoiedcally expressed homeobox 48
420605 BE391491 Hs 99291 HSPC156 protein 47
422482 AI439905 Hs 344476 gb tι57g08 x1 NCI_CGAP_Lym12 Homo sapien 47
416636 N32536 Hs 42645 solute earner family 16 (monocarboxylic 47
409263 AA069573 Hs 50319 ESTs 47
410657 AF063228 Hs 65248 dynein, cytoplasmic, intermediate polype 46
457216 AA452554 Hs 283697 ESTs Weakly similar to A41796 neural re 46
433423 BE407127 Hs 8997 heat shock 70kD protein 1 A 46
449901 AI674072 gb wd15h01 x1 Soares.NFL_T_GBC.S1 Homo s 46
445618 H79667 Hs 237642 Homo sapiens cDNA FU12052 fis, clone HE 46
431582 F07136 Hs 261828 G protein-coupled receptor kinase 7 45
424675 NM 005512 Hs 151641 glycoprotein A repeddons predominant 45
449511 AI436187 Hs 296261 guanine nucleotide binding protein (G pr 45
401600 BE247275 U5 snRNP-specific protein, 116 kD 45
447135 T58148 gb yb98g06 s1 Stratagene lung (937210) H 45
426689 BE245550 Hs 171825 basic helix-loop-helix domain containing 44
429598 AA811257 Hs 269710 ESTs 44
428206 AB020643 Hs 183006 KIAA0836 protein 44
450715 AI266484 Hs 31570 ESTs, Weakly similar to KIAA1324 protein 44
428508 BE252383 Hs 184668 SBBI31 protein 44
435145 AI277259 Hs 116631 ESTs 44
405670 C2000627* gι|12034653|gb|AAG45951 1|AF22 44
442321 AF207664 Hs 8230 a disintegnn-like and metalloprotease ( 43
427670 BE612888 Hs 180224 myosin regulatory light chain 43
428465 AW970976 Hs 293653 ESTs 43
449180 AI633836 Hs 195649 ESTs 43
402364 AV653231 CCAAT/enhancer binding protein (C/EBP), 43
426471 M22440 Hs 170009 transforming growth factor, alpha 4 2
419386 AA236867 ESTs, Weakly similar to I38022 hypothed 42
441408 AI733249 Hs 126897 ESTs 42
419631 AW188117 Hs 303154 popeye protein 3 42
409231 AA446644 Hs 692 GA733-2 antigen, epithelial glycoprotein 42
448958 AB020651 Hs 22653 KIAA0844 protein 42 421878 AA299652 Hs 111496 Homo sapiens cDNA FU11643 fis, clone HE 42
422278 AF072873 Hs 114218 frizzled (Drosophila) homolog 6 42
459053 AI807052 Hs 210361 ESTs 4 1
450600 BE079478 Hs 24880 ESTs 4 1
415839 R40611 Hs 94694 ESTs 4 1
450374 AA397540 Hs 60293 Homo sapiens clone 122482 unknown mRNA 4 1
422270 AF114494 Hs 114062 protein tyrosine phosphatase-like (proli 4 1
405674 NM 022775 Homo sapiens hypothedcal prot 4 1
453906 AW444952 Hs 257054 ESTs 41
419318 AW969742 Hs 291005 ESTs 40
456382 NM.001126 Hs 90011 adenylosuccinate synthase 40
435902 AA701867 Hs 297726 ESTs 40
449483 AK001971 Hs 23607 hypothedcal protein FU 11109 40
434228 Z42047 Hs 283978 Homo sapiens PR02751 mRNA, complete eds 40
403890 C5002036" gι|10241574|emb|CAC09416 1| (A 40
429470 AI878901 Hs 203862 guanine nucleotide binding protein (G pr 40
409856 AW502082 gb UI-HF-BROp-ajq-g-04-O-UI rl NIH_MGC_5 40
443682 AI383061 Hs 47248 ESTs, Highly similar to similar to Cdc14 40
420230 AL034344 Hs 284186 forkhead box C1 40
410509 AW840743 gb QV1-CN0002-080300-102-f07 CN0002 Homo 40
428414 AL049980 Hs 184216 DKFZP564C152 protein 39
400138 Eos Control 39
451522 BE565817 Hs 26498 hypothedcal protein FU21657 39
436521 AW203986 Hs 213003 ESTs 39
401507 C15000810" gι|11131272|sp|P79331|ATS2_BO 39
449785 AI225235 Hs 288300 hypothedcal protein FLJ23231 39
434815 AF155582 Hs 46744 Corel UDP-galactose N acetylgalactosamm 39
411906 AW875765 gb QV2-PT0012-020500-186-a08 PT0012 Homo 39
440509 BE410132 Hs 134202 ESTs, Weakly similar to T17279 hypothed 39
427061 AB032971 Hs 173392 KIAA1145 protein 39
430261 AA305127 Hs 237225 hypothetical protein HT023 39
449658 AI964033 Hs 195730 ESTs, Weakly similar to CTXN RAT CORTEXI 38
429876 AB028977 Hs 225974 KIAA1054 protein 38
410330 AW023630 Hs 159425 ESTs 38
431369 BE184455 Hs 251754 secretory leukocyte protease inhibitor ( 38
437659 AB007944 Hs 5737 KIAA0475 gene product 38
438171 AW976507 Hs 293515 ESTs 38
418394 AF132818 Hs 84728 Kruppel-like factor 5 (intestinal) 38
405586 NM_000299 Homo sapiens plakophilm 1 (ec 38
432298 AL118812 Hs 274293 Homo sapiens mRNA, cDNA DKFZp761 G1111 (f 38
426716 NM_006379 Hs 171921 sema domain, immunoglobulin domain (lg), 38
438202 AW169287 Hs 22588 ESTs 38
404606 Target Exon 38
425329 AI961644 Hs 145444 Homo sapiens cDNA FLJ 11494 fis clone HE 38
407604 AW191962 Hs 288061 collagen, type VIII, alpha 2 38
416498 U33632 Hs 79351 potassium channel, subfamily K, member 1 37
430868 W93178 Hs 5232 HSPC125 protein 37
457008 AA410446 Hs 112011 ESTs, Weakly similar to unknown [H sapie 37
458660 AI299739 Hs 99601 hypothedcal protein FU12553 37
408732 AL117490 Hs 47225 Ras associated protein Rap1 37
436281 AW411194 Hs 85195 myeloid leukemia fxtor 1 37
413493 BE144444 gb MR0-HT0168-141199-002-f09 HT0168 Homo 37
418407 AL044818 Hs 84928 nuclear transcπption factor Y, beta 37
445797 AI253414 gb aq14f04 x1 Stanley Frontal NS pool 2 37
457121 AI743770 Hs 180513 ESTs, Weakly similar to KIAA0822 protein 36
417620 R02530 Hs 191198 ESTs 36
421952 AA300900 Hs 98849 ESTs, Moderately similar to AF161511 1 H 36
454247 AJ243950 Hs 46735 deafness locus associated putadve guam 36
431662 AA513406 Hs 152307 ESTs 36
426908 AW815163 Hs 172851 arg ase, type II 36
438519 AI186033 Hs 147025 ESTs, Weakly similar to C57785 zinc fing 36
415606 W70022 gb zd51e10 r1 Soares fetal heart_NbHH19W 36
444859 AW449137 Hs 157487 ESTs 36
414631 AW970130 Hs 65406 ESTs 36
428897 AJ245719 Hs 194385 hypothedcal protein FLJ20234 35
437073 AI885608 Hs 94122 ESTs 35
427287 NM 014903 Hs 174188 KIAA0938 protein 35
415927 AL120168 Hs 78919 Kell blood group precursor (McLeod pheno 35
450235 AA007512 Hs 17538 ESTs 35
447263 AW965667 Hs 322406 hypothedcal protein FU 14494 35
419440 AB020689 Hs 90419 KIAA0882 protein 35
427254 AL121523 Hs 97774 ESTs 35
434348 BE393191 Hs 181795 putadve b,b-carotene-9\10'-dιoxygenase 35
441264 AA927170 Hs 23290 ESTs 35
433629 R13140 Hs 13359 ESTs 35
446494 AA463276 Hs 288906 WW Domain-Containing Gene 35
441585 AI760755 Hs 202383 ESTs 35
438704 AI435060 Hs 32825 ESTs 34
445279 R41900 Hs 22245 ESTs 34
415114 D60468 Hs 94181 ESTs 34
449561 AI022240 Hs 17924 ESTs, Moderately similar to ALU1 HUMAN A 34
452420 BE564871 Hs 29463 centπn EF-hand protein 3 (CDC31 yeast 34
416517 AA775987 Hs 79357 proteasome (prosome, macropain) 26S subu 34 441134 W29092 Hs 346950 cellular retinoic acid-bindmg protein 1 34
427176 AW381569 Hs 40334 ESTs 34
415668 AW957684 Hs 306814 hypothedcal protein FU21889 34
450928 AI744417 gb tr10h12 x1 NCI CGAP Ov23 Homo sapiens 34
457012 R41480 Hs 302754 ESTs 33
405354 CX000321 gι|6671579|reflNP.031518 1| an 33
408855 T83061 Hs 319946 Homo sapiens mRNA for KIAA1727 protein, 33
418525 AW450369 Hs 86937 ESTs 33
420174 AI824144 Hs 23912 ESTs 33
437124 AA554458 Hs 279860 KIAA0666 protein 33
419211 BE270817 Hs 37617 ESTs, Weakly similar to A53933 myosin I 33
424335 AW021508 Hs 28170 ESTs 33
453344 BE349075 Hs 44571 ESTs 33
428065 AI634046 Hs 157313 ESTs 33
417248 AA329449 Hs 247302 twisted gastruladon 33
429415 NM.002593 Hs 202097 procollagen C-endopepddase enhancer 33
411393 AW797437 Hs 69771 B-factor, properdm 33
406976 M60299 gb Human alpha-1 collagen type II gene, 33
441071 D79550 Hs 7149 Homo sapiens cDNA FU21950 fis, clone H 33
414327 BE408145 Hs 185254 ESTs, Weakly similar to T24435 hypothed 33
433703 AA210863 Hs 3532 nemo-like kinase 33
418880 N87353 Hs 89421 CBF1 interacdng corepressor 33
445947 AW612084 Hs 298494 ESTs 33
437334 AL353947 Hs 283780 hypothedcal protein OKFZp761N1814 33
434795 BE620794 Hs 4147 translocadng cham-associadng membrane 32
400127 Eos Control 32
414602 AW630088 Hs 76550 Homo sapiens mRNA, cDNA DKFZp564B1264 (f 32
402429 Target Exon 32
428695 AI355647 Hs 189999 puπnergic receptor (family A group 5) 32
427699 AW965076 Hs 180378 hypothetical protein 669 32
403442 Target Exon 32
419272 AA663904 Hs 89862 TNFRSF1 A-associated via death domain 32
456614 AV653110 Hs 106650 hypothetical protein FU20533 32
407581 R48402 Hs 173508 P3ECSL 32
412633 AF001691 Hs 74304 peπplakin 32
433328 AW298159 Hs 23644 ESTs, Weakly similar to S65824 reverse t 32
449294 AI651786 Hs 195045 ESTs 3 1
442799 AI564739 Hs 68505 ESTs 3 1
434045 AI065133 Hs 152316 hypothetical protein PRO0971 31
409403 AA668224 Hs 6634 Homo sapiens cDNA FU22547 fis, clone H 3 1
420033 D59502 Hs 292590 ESTs 3 1
422137 AJ236885 Hs 112180 zinc finger protein 1 8 (pHZ-52) 3 1
444760 AI796296 Hs 208062 ESTs 3 1
403488 ENSP00000201948 KARYOPHERIN BETA2B HOMOL 3 1
411359 H86088 Hs 22635 ESTs 3 1
443037 AW500305 Hs 8906 syntaxin 7 3 1
407127 R45970 Hs 236349 EST 3 1
416851 AW963951 Hs 85618 ESTs 3 1
416838 D84109 Hs 80248 RNA-bmding protein gene with muldple s 3 1
443030 R68048 Hs 9238 hypothetical protein FLJ23516 3 1
410389 AW954049 Hs 8177 ESTs, Weakly similar to PIHUB6 salivary 3 1
459399 BE407712 Hs 153998 creadne kinase mitochondnal 1 (ubiqui 3 1
433582 BE548749 Hs 148016 ESTs 3 1
431128 AI203545 Hs 296169 S phase response (cyclin-related) 3 1
420411 AI581085 Hs 24678 sphιngosιπe-1-phosphatase 3 1
459584 AI910884 Hs 346429 ESTs 3 1
449883 AI004464 Hs 344156 gb Ot56e06 s1 Soares_testιs_NHT Homo sap 3 1
445320 AA503887 Hs 167011 Homo sapiens cDNA FU21362 fis, clone C 3 1
410786 AW803340 gb IL2-UM0079-090300-050-D02 UM0079 Homo 3 1
418207 C14685 Hs 34772 ESTs 30
420521 AI915734 Hs 87298 ESTs 30
425890 H24530 Hs 273294 hypothedcal protein FU20069 30
416749 AW068550 comp Hs 79732 fibulin 1 30
412258 AA376768 Hs 324841 hypothedcal protein FU22622 30
407173 T64349 gb yc10d08 s1 Stratagene lung (937210) H 30
415672 N53097 Hs 193579 ESTs 30
448583 NM 015239 Hs 21542 KIAA1035 protein 30
429043 AI824977 Hs 145319 ESTs 30
404091 Target Exon 30
406085 Target Exon 30
438825 BE327427 Hs 79953 ESTs 30
457441 BE467737 Hs 146125 ESTs 30
403512 C3000579* gι|12643308|sp|Q9Y4K1|AIM1_HUM 30
416866 AA297356 Hs 80324 seπne/threomne protein phosphatase cat 30
439877 H39685 Hs 250700 tryptase beta 1 30
441984 AB037763 Hs 8059 synaptotagmin IV 30
436765 AB028952 Hs 5307 synaptopodin 30
445071 AI280246 Hs 149504 ESTs 30
404333 C7001735* gι|7768636|db||BAA95483 1| (AB 30
422907 AI879263 Hs 77273 Human glucose transporter pseudogene 30
413266 BE300352 gb 600944231F1 NIH_MGC_17 Homo sapiens c 30
429393 AA383024 Hs 201603 Homo sapiens mRNA, cDNA DKFZp434D0917 (f 30
415337 Z44881 Hs 9012 ESTs, Weakly similar to S26650 DNA-bindi 30 415044 AA419108 Hs 77840 annexin A4 29
403469 Target Exon 29
416928 AA190573 Hs 85902 ESTs, Weakly similar to MCHU calmodulm 29
430195 AW969308 Hs 188594 ESTs 29
458544 AI631036 Hs 196843 ESTs 29
440667 BE076969 Hs 7337 hypothetical protein FU10936 29
424641 AB001106 Hs 151413 glia maturation factor, beta 29
428820 AA436187 Hs 172631 integnn, alpha M (complement component 29
405403 Target Exon 29
452197 AW023595 Hs 232048 ESTs 29
437357 AL359559 Hs 331666 Homo sapiens mRNA, cDNA DKFZp76202215 (f 29
423479 NM.014326 Hs 129208 death-associated protein kinase 2 29
404559 Target Exon 29
406270 Target Exon 29
422190 H17399 Hs 11506 Human clone 23589 mRNA sequence 29
431300 AA502346 gb ne26b03 s1 NCI.CGAP Co3 Homo sapiens 29
420286 AI796395 Hs 111377 ESTs 29
422964 AW439476 Hs 256895 ESTs 29
431583 AL042613 Hs 262476 S-adenosylmethionme decarboxylase 1 29
428595 AB037795 Hs 186547 KIAA1374 protein 29
402198 NM_024323 Homo sapiens hypothedcal prot 29
416246 U47413 Hs 79101 cyclm G1 29
427593 AK001132 Hs 179752 Homo sapiens cDNA FU10270 fis, clone HE 29
446351 AW444551 Hs 35380 x 001 protein 29
440432 AI239637 Hs 202653 ESTs, Weakly similar to T14267 Xin prote 29
446525 AW967069 Hs 211556 hypothedcal protein MGC5487 28
400965 C11002190" gι|12737279|ref|XP_012163 1| 28
436489 AJ272269 Hs 121429 zinc-binding protein Rbcc728 28
458793 N80159 Hs 121849 microtubule-associated proteins 1A/1B Ii 28
406810 U82275 Hs 94498 leukocyte immunoglobulm-like receptor, 28
445577 N40696 Hs 137064 cytoplasmic polyadenyladon element bind 28
428874 W32133 Hs 194366 transthyredn (prealbumin, amyloidosis t 28
418745 AW882645 Hs 88044 sprouty (Drosophila) homolog 1 (antagoni 28
433095 AK001092 Hs 302480 Homo sapiens cDNA FU1O230 fis, clone HE 28
425580 L11144 Hs 1907 galamn 28
416233 AA176633 gb zp13g01 s1 Stratagene fetal redna 93 28
438219 AI916151 Hs 257194 ESTs 28
404661 C9000306* gι|12737280|ref|XP_0066822| k 28
435836 AW292532 Hs 343667 homolog of yeast long chain polyunsatura 28
423665 BE167153 Hs 24380 ESTs 28
430320 BE245290 Hs 239218 uncharactenzed hypothalamus protein HCD 28
401783 NM 003771* Homo sapiens keradn, hair, a 28
423837 AW937063 Hs 275150 gb PM3-DT0037-231299-001 -g 11 DT0O37 Homo 28
447271 AL041747 Hs 170261 ESTs 28
438913 AI380429 Hs 172445 ESTs 28
441962 AW972542 Hs 289008 Homo sapiens cDNA FU21814 fis, clone H 28
444385 BE278964 Hs 11085 CGI-111 protein 28
432278 AL137506 Hs 274256 hypothedcal protein FU23563 28
415666 H72693 gb yu03c11 r1 Soares fetal liver spleen 28
452345 AA293279 Hs 29173 hypothetical protein FLJ20515 28
445898 AF070623 Hs 13423 Homo sapiens clone 24468 mRNA sequence 28
439556 AI623752 Hs 163603 ESTs 28
405474 NM 001093* Homo sapiens acetyl Coenzyme 28
426208 AI370379 Hs 132216 ESTs 28
419461 AI452601 Hs 288869 nuclear receptor subfamily 2, group F, m 28
428501 AL041162 Hs 98587 ESTs 28
413427 U31120 Hs 845 interieukin 13 28
433109 N58907 Hs 162430 EST 28
427974 BE093023 Hs 188767 ESTs 28
455040 AW852286 gb QVO-CT0225-100400-187-d08 CT0225 Homo 28
453994 BE180964 Hs 165590 nbosomal protein S13 28
459171 AW967801 Hs 64783 ESTs, Weakly similar to T42705 hypotheti 28
404845 C22000163* gι|10242166|gb|AAG15318 1|AF2 28
408182 AA047854 gb zf49g04 r1 Soares redna N2b4HR Homo 28
427111 AA351026 Hs 1 3594 serine (or cysteine) proteinase inhibito 27
414541 BE293116 Hs 76392 aldehyde dehydrogenase 1 family, member 27
432815 Z30045 Hs 293676 ESTs 27
404036 Target Exon 27
418157 W99382 Hs 283709 lipopolysacchaπde specific response-7 p 27
426403 NM 000361 Hs 2030 thrombomodulin 27
439659 AW970780 Hs 59483 Homo sapiens cDNA FLJ14471 fis clone MA 27
443932 AW888222 Hs 9973 tensin 27
444930 BE185536 Hs 301183 molecule possessing ankynn repeats indu 27
419269 AA235838 gb zs41b04 s1 Soares.NhHMPu.S1 Homo sapi 27
416004 D11880 Hs 299254 Homo sapiens cDNA FLJ 23597 fis, clone L 27
430371 D87466 Hs 240112 KIAA0276 protein 27
449117 AW449310 Hs 210262 ESTs, Weakly similar to HSS2 HUMAN HEPAR 27
451007 H38108 Hs 32759 ESTs 27
421202 AF193339 Hs 102506 eukaiγodc translation midadon factor 27
406308 NM.025192 Homo sapiens hypothedcal prot 27
413208 BE071799 gb RC0-BT0522-071299-011-b10 BT0522 Homo 27
421420 AI024236 Hs 123296 ESTs, Weakly similar to PEC1.HUMAN PLATE 27
445693 AW800444 Hs 76507 LPS-induced TNF-alpha factor 27 452351 AA025647 gb ze85d01 r1 Soares_fetal_heart.NbHH19W 27
410538 AW753115 gb PM0-CT0248-131099-001-h12 CT0248 Homo 27
448072 AI459306 Hs 24908 ESTs 27
420912 AW853156 Hs 90787 ESTs 27
453830 AA534296 Hs 20953 ESTs 27
457791 AW117431 Hs 191906 ESTs 27
417735 AA188175 Hs 82506 KIAA1254 protein 27
411773 NM 006799 Hs 72026 protease, senne, 21 (tesdsin) 27
417076 AW973454 Hs 238442 ESTs. Moderately similar to ALU7.HUMAN A 27
436476 AA326108 Hs 33829 bHLH protein DEC2 27
440945 AW505345 HS 7540 f-box and leucine-nch repeat protein 3A 27
425826 U97698 mucin 6, gastric 27
422795 AB033109 Hs 120866 KIAA1283 protein 27
433921 AA618174 gb nq14f01 s1 NO CGAP Thy1 Homo sapiens 27
414272 AI651603 Hs 46988 ESTs 27
418047 R37633 Hs 4847 ESTs 27
421089 AB037771 Hs 101799 KIAA1350 protein 27
419763 AI039691 Hs 127486 ESTs 27
459265 AJ003616 gb AJ003616 Selected chromosome 21 cDNA 27
410970 AW812151 gb RC5-ST0178-081099-011-A06 ST0178 Homo 27
401925 N98378 sialyltransferase 1 (bet---galactos.de al 27
418504 BE159718 Hs 85335 Homo sapiens mRNA cDNA DKFZp564D1462 (f 26
433789 AA220977 gb zr01a08 r1 Stratagene NT2 neuronal pr 26
418308 AA215738 Hs 182514 ESTs, Weakly similar to A46010 X-lmked 26
444618 AV653785 Hs 173334 ELL-RELATED RNA POLYMERASE II, ELONGATIO 26
406299 Taiget Exon 26
422963 M79141 Hs 13234 ESTs 26
441244 BE612935 Hs 184052 PP1201 protein 26
439954 AL046748 Hs 6790 DnaJ (Hsp40) homolog, subfamily B, membe 26
405088 Taiget Exon 26
404741 Target Exon 26
451927 AL355687 Hs 27261 Homo sapiens mRNA full length insert cDN 26
439103 AF085959 Hs 38705 ESTs 26
437241 AL137318 Hs 306450 Homo sapiens mRNA, cDNA DKFZp434L171 (fr 26
442379 NM 004613 Hs 8265 transglutaminase 2 (C polypepdde, prote 26
457394 M86528 Hs 266902 neurotrophin 5 (neurotrophm 4/5) 26
427229 AI799751 HS 5635 ESTs 26
414630 BE410857 Hs 16064 gb 601301177F1 NIH_MGC.21 Homosapiens c 26
406744 AA554082 Hs 279860 tumor protein, traπslationally-confrolle 26
443984 AI424415 Hs 143719 ESTs 26
421221 AW276914 Hs 326714 Homo sapiens clone IMAGE 713177, mRNA se 26
421709 AA159394 Hs 107056 CEO-6 protein 26
426747 AA535210 Hs 171995 kallikrein 3, (prostate specific andgen 26
439480 AL038511 Hs 125316 ESTs, Weakly similar to S33990 finger pr 26
419567 AW339890 Hs 128187 ESTs 26
421922 AW295043 Hs 109590 genethomn 1 26
421859 AA356620 Hs 108947 KIAA0050 gene product 26
431441 U81961 Hs 2794 sodium channel, nonvoltage-gated 1 alpha 26
444843 AA400172 gb zu69e01 r1 Soares_testιs_NHT Homo sap 26
416729 U46165 Hs 1027 Ras-related associated with diabetes 26
439238 N47305 Hs 302161 ESTs 26
439183 AW970600 Hs 303261 ESTs 26
408739 W01556 Hs 238797 ESTs, Moderately similar to 138022 hypot 26
412061 AA833763 Hs 330211 ESTs 26
432114 AL036021 Hs 8934 ESTs 26
425337 AA355442 Hs 169054 ESTs 26
424299 AK000377 Hs 82294 homolog of mouse C2PA 26
448871 BE616709 Hs 159265 krυppel related zinc finger protein hcKr 26
414516 AI307802 Hs 135560 ESTs, Weakly similar to T43458 hypothed 26
456235 AA203637 gb zx58b12 r1 Soares.fetal.liver.spleen. 26
410429 AA310600 Hs 63657 peptide N-glycanase similar to yeast PNG 26
449251 AW151660 Hs 31444 ESTs 26
436546 AW023329 Hs 132743 ESTs 26
450546 AA010200 Hs 175551 ESTs 26
437255 R58970 Hs 9887 ESTs 26
409041 AB033025 Hs 50081 Hypothetical protein, XP_051860 (KIAA119 26
427983 M17706 Hs 2233 colony sdmuladng factor 3 (granulocyte 25
413341 H78472 Hs 191325 ESTs, Weakly similar to T18967 hypothed 25
423763 R98203 Hs 132724 nuclear transcπption factor Y, alpha 25
413282 BE078159 gb CMO-BT0615-140200-175-e06 BT0615 Homo 25
415590 T74068 Hs 170081 gb yc81(07 r1 Soares infant bran 1NIB H 25
406215 Target Exon 25
453938 AF082569 Hs 36794 D-type cyclin-mteracdng protein 1 25
424310 AA338648 Hs 50334 testes development-related NYD-SP22 25
442097 AW015799 Hs 128474 ESTs 25
456650 AA620501 Hs 106773 ESTs, Weakly similar to T42689 hypotheti 25
413231 D87461 Hs 75244 BCL2-lιke 2 25
457297 AW968188 gb EST380383 MAGE resequences, MAGJ Homo 25
444942 AW293458 Hs 283807 chromosome 11 open reading frame 16 25
425764 AW996009 Hs 112572 Homo sapiens cDNA FU14130 fis, clone MA 25
435712 AA694607 Hs 176956 ESTs 25
436624 T64297 fatty acid binding protein 1, liver 25
443155 R54485 Hs 23772 ESTs 25 425907 AA365752 Hs 155965 ESTs 25
414759 AW295157 Hs 47587 ESTs 25
414699 AI815523 Hs 76930 synuclem, alpha (non A4 component of am 25
411426 BE141714 gb QVO-HT0101-061099-032-C04 HT0101 Homo 25
404492 C8000067* gι|10432400|emb|CAC10290 1| (A 25
425153 AW023193 Hs 27046 ESTs 25
426372 BE304680 Hs 169531 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 25
434803 AW974640 Hs 303413 ESTs 25
425694 U51333 Hs 159237 hexok ase 3 (white cell) 25
433069 X76732 Hs 3164 nucleobmdin 2 25
428054 AI948688 Hs 266619 ESTs 25
424823 NM.006226 Hs 153322 phospholipase C, epsilon 25
456972 AI054347 Hs 2017 nbosomal protein L38 25
431405 AI470895 Hs 334895 nbosomal protein L10a 25
427982 NM 016156 Hs 181326 KIAA1073 protein 25
412831 AA121352 Hs 143314 ESTs 25
437114 AA836641 Hs 163085 ESTs 25
426157 AA370977 Hs 345728 STAT induced STAT inhibitor 3 25
448786 BE048842 Hs 179075 Homo sapiens cDNA FU 11881 fis, done HE 25
432251 AW972983 Hs 232165 polycythemia rubra vera 1, cell surface 25
449239 T24653 Hs 23360 likely ortholog of yeast ARV1 25
453572 AA382590 Hs 46366 KIAA0948 protein 25
TABLE 23B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accessior i numbers
Pkey CAT Number Accession
408182 104479 1 AA047854 AA057506 AA053841
409856 1156268 1 AW502O82 AW502979 AW502807 AW501876
410509 1206699 1 AW840743 AW752404 H43469
410538 1207341 1 AW753115 AW753113 R45779
410786 1221063 1 AW803340 AW803280 AW803275 AW803415 AW803343 AW803422
410970 1228131 1 AW812151 AW812186 AW812166
411426 1245515.1 BE141714 AW845993 AW845989
411906 1265204 1 AW875765 H50294 AW875444
412636 13165 1 NM 004415 AL031058 M77830 BE149760 AW752599 AW848723 AW376697 Al /V3768'
AW849074 AW997139 AW799304 AW799309 BE077020 BE077017 BE185187 AW997196 BE156621 BE179915 BE006561 BE143155 AW890985
BE002107 AW103521 AA857316 AW383133 BE011378 AW170253 BE185750 AW886475 BE160433 J05211 BE082576 BE082584 BE004047
AW607238 AW377700 AW377699 BE082526 BE082505 BE082507 BE082514 AW178000 AW177933 AI905935 AW747877 AW748114 BE148516
AW265328 AW847678 AW847688 AW365151 AW365148 AW365153 AW365156 AW365175 AW365157 AW365154 AW068840 BE005272 AW365145
BE001925 BE182166 BE144243 BE001923 AI951766 AI434518 BE184920 BE184933 AI284090 BE184941 AW804674 BE184924 C04715 W39488
AW995615 BE1849488E159646 AW606653 AA099891 AA131128 AA337270 AA340777 AW384371 AA852212 R58704 AW366566 AW364859
AA025851 AA025852 AA455100 AA719958 AW352220 AW996245 BE165351 BE073467 AA377127 AW890264 AW609750 AW391912 AW849690
T87267 AW853812 AA852213 W74149 BE009090 AA056401 H91011 AW368529 AW390272 C18467 AW674920 N57176 AA026480AW576767
H93284 AA026863 AW177787 AA026654 AW177786 BE092134 BE092137 BE092136 AW177784 AI022862 BE091653 AW376811 AW848592
AA040018 BE185331 BE182164 AA368564 AW951576 T29918 AA131077 W95048 W25458 AW205789 H90899 N29754 W32490 R20904 BE167181
BE167165 N84767 H27408 H30146 AI190590 C03378 AI554403 AI205263 AA128470 AI392926 AF139065 AW370813 AW370827 AW798417
AW798780 AW798883 AW798569 R33557 AA149190 C03029 AW177783 AA088866 AW370829 AA247685 BE002273 AI760816 AI439101 AW879451
AI700963 AA451923 AI340326 AI590975 T48793 AI568096 AI142882 AA039975 AI470146 AA946936 BE067737 BE067786 W19287 AA644381
AA702424 AI417612 AI306554 AI686869 AI568892 AW190555 AI571075 Al 220573 AA056527 AI471874 AI304772 AW517828 AI915596 AI627383
AI270345 AW021347 AW166807 AW105614 AI346078 AA552300 W95070 AI494069 AI911702 AA149191 AA026864 AI830049 AI887258 AW780435
AI910434 AI819984 AI858282 AI078449 AI025932 AI860584 AI635878 AA026047 AA703232 D12062 AW192085 AA658154 AW514597 AW591892
T87181 AA782066 AW243815 AW150038 AW268383 AW004633 AI927207 AA782109 AW473233 AI804485 AW169216 AI572669 AA602182
AW015480 AW771865 AI270027 AA961816 AA283207 AI076962 AI498487 AI348053 AI783914 H44405 AW799118 AA128330 AA515500 AA918281
W02156 AI905927 AA022701 W38382 R20795 T77861 AW860878
413208 1353610 1 BE071799 BE071804 BE071798
413266 1356260 1 BE300352 BE299274 BE075351 BE297444
413282 1358147.1 BE078159 BE078276 BE078163 BE078277 BE078279 BE078158
413493 1373555.1 BE144444 BE144430
415606 1540470 1 W70022 R35201 F12763 T74725 H63485 Z45782 H61126
415666 1543492 1 H72693 R08673 H72694 F20990 R08580
416233 158010 1 AA176633 AW961842 AA309418
419269 183444 1 AA235838 BE180775
419386 184356 1 AA236867 AA237066 AA354236 AW957759 H08961
425826 25682 1 U97698 AW815264 AI791966 AI732669 AA588236 AI521662 AI804760 AI955717 AW292169 AI468227 AI420483 AA603459 AI868225 AI919551
431300 331217.1 AA502346 BE159863
433789 37421 1 AA220977 AF091029 AA701227
433921 377350 1 AA6181 4 Al 114549 R36464 R36465
436624 4237.5 T64297 AA894931 NM.001443 M10050 AW843109 AI698516 T53219 T48785 T64166 AA706930 R29613 T55913 T56518 T64679 R29666 M10617
AI768596 AA101894 W90338 AI742193 AW752206 AA099433 T53220 AW082135 AW272775 T29562 T55862 AI343047 AI345671 T68235 T68121
AW842284
444843 62260.1 AA400172 AA400146 AV651691
445797 650943 1 AI253414 AI366014 R34822
447135 70963 1 T58148 AW516579 AW059603
449901 818599 1 AI674072 BE268487
450928 851593 1 AI744417 R91614 H77365
452351 91233 1 AA025647 R45716 AW753786
455040 1250028 1 AW852286 AW851934 AW852096 AW852274
456235 168686 1 AA203637 AA832266 H67452
457297 313764 1 AW968188 AA468196 AA468269 AA468298
459265 966590 1 AJ003616 AJ003654 AJ003617 TABLE 23C
Pkey Uniqt iβ number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to th sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted
NLposidoπ i Indicates nucleodde positions of predicted exons
Pkey Ref Strand NLposrtion
400965 7770576 Minus 173043-173564
401507 7534110 Plus 71055-71259
401600 4388746 Minus 27363-27518,28727-28891 ,29526-29731
401783 7249190 Plus 139369-139827,140509-140591,140834-140990,141496-141657,141757-141882,142063-142283
401925 3892083 Minus 138252-138469,140239-140364,140437-140598,141037-141193,141925-142007,142787-143230
402198 8576116 Plus 79041-79191
402364 9454515 Minus 54983-55240,56507-56785,56982-57365
402429 9796372 Minus 57622-57793,59282-59402,59624-59827
403442 7210003 Plus 174560-175270
403469 9929739 Minus 4831-7707
403488 9966615 Minus 12450-12753
403512 7656757 Minus 114487-114610
403890 7710561 Plus 83165-83350
404036 8567760 Minus 65247-67529,112537-114863
404091 7684554 Minus 82121-83229
404333 9802821 Minus 137948-138024,138111-138300
404492 8123400 Minus 138612-138803
404559 8748893 Minus 73499-73651,89575-89739
404606 9212936 Minus 22310-23269
404661 9797073 Plus 33374-33675,33769-34008
404741 8574139 Plus 143025-143467
404845 7958980 Minus 47174-47326,52928-5314653312-53602
405088 8072518 Minus 115690-117621
405354 2642452 Plus 52213-53089
405403 6850244 Minus 37491-37670.40951-41031
405474 8439781 Plus 172005-172175
405586 5002511 Plus 38810-39017
405670 4662655 Plus 96543-96870
405674 4589984 Plus 68302-68429
406085 9123888 Plus 18665-18843
406215 7342161 Plus 310-432
406270 7534217 Plus 13136-13591
406299 5686278 Minus 35655-36119
406308 9211532 Plus 358408-358651
TABLE 24A ABOUT 1260 GENES UP-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT TISSUES
Table 24A lists about 1260 genes up-regulated in glioblastoma compared to normal adult tissues These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip anay such that the rado of "average" glioblastoma to "average" normal adult dssues was greater than or equal to 25 The "average" glioblastoma level was set to the 75* percendle amongst vaπous glioblastoma tumors The "average" normal adult dssue level was set to the 85* percendle amongst vanous non-malignant dssues In order to remove gene-specific background levels of non-specific hybndization, the 10* percendle value amongst the vaπous non-malignant dssues was subtracted from both the numerator and the denominator before the ratio was evaluated
Pkey Unique Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Tide Unigene gene title
R1 Ratio of 75* percentile tumor to 85* percendle nomial body dssue
Pkey ExAccn UnigenelD Unigene Title R1
431917 D16181 Hs 2868 penpheral myelin protein 2 75 2
427343 AI880044 Hs 176977 protein kinase C binding protein 2 746
455601 AI368680 Hs 816 SRY (sex determining region Y)-box 2 742
428321 AI699994 Hs 2868 penpheral myelin protein 2 71 6
412719 AW016610 Hs 129911 ESTs 707
449494 AW237014 Hs 315369 Homo sapiens cDNA FLJ23075 fis, clone L 663
415817 U88967 Hs 78867 protein tyrosine phosphatase, receptor-t 643
413472 BE242870 Hs 75379 solute earner family 1 (glial high affi 60 1
456759 BE259150 Hs 127792 delta (Drosophιla)-lιke 3 523
435147 AL133731 Hs 4774 Homo sapiens mRNA, cDNA DKFZp761C1712 (f 467
425842 AI587490 Hs 159623 NK-2 (Drosophila) homolog B 401
412733 AA984472 Hs 74554 KIAA0080 protein 390
418375 NM 003081 Hs 84389 synaptosomal-associated protein, 25kO 387
453392 U23752 Hs 32964 SRY (sex determining region Y)-box 11 37 2
423849 AL157425 Hs 133315 Homo sapiens mRNA. cDNA DKFZp761J1324 (f 368
413333 M74028 Hs 75297 fibroblast growth factor 1 (acidic) 328
416829 AB013805 Hs 80220 catenin (cadheπn-associated protein) d 31 8
431941 AK000106 Hs 272227 Homo sapiens cDNA FU20099 fis. clone CO 31 8
436878 BE465204 Hs 47448 ESTs 31
426325 D28114 Hs 169309 myelin-associated oligodendrocyte basic 309
425057 AA826434 Hs 1619 achaete-scute complex (Drosophila) homol 304
446711 AF169692 Hs 12450 protocadheπn 9 302
439415 F05538 Hs 12825 ESTs 283
430838 N46664 Hs 169395 hypothedcal protein FLJ 12015 269
429466 M85835 Hs 12827 ESTs 259 447004 AW296968 Hs 157539 ESTs 253
424581 M62062 Hs 150917 catenin (cadheπn-associated protein), a 248
452744 AI267652 Hs 30504 Homo sapiens mRNA, cDNA DKFZp434E082 (fr 24 8
441285 NM 002374 Hs 167 microtubule-associated protein 2 243
453642 AI370936 Hs 34074 dipepddylpepddase VI 24 3
424140 Z48051 Hs 141308 myelin oligodendrocyte glycoprotein 242
450133 AW969769 Hs 105201 ESTs 242
408562 AI436323 Hs 31141 Homo sapiens mRNA for KIAA1568 protein, 2 3
448672 AI955511 Hs 225106 ESTs 227
435708 AI362949 Hs 75169 ESTs 220
407034 U84540 gb Human dystrobrevm isoform DTN-3 (DTN 21 9
407168 R45175 Hs 117183 ESTs 21 7
431019 NM 005249 Hs 2714 forkhead box G1B 21 5
409049 AI423132 Hs 146343 ESTs 21 4
433896 AW294729 Hs 274461 ESTs 21 1
445041 T64183 Hs 282982 solute earner 21 0
418738 AW388633 Hs 6682 solute earner family 7, (cadonic ammo 204
444378 R41339 Hs 12569 ESTs 200
411305 BE241596 Hs 69547 myelin basic protein 199
437414 AW894071 Hs 48448 hypothedcal protein DKFZp547C176 198
441016 AW138653 Hs 25845 ESTs 196
440435 AL042201 Hs 21273 transcπption fador NYD-sp10 185
438209 AL120659 Hs 6111 aryl-hydrocarboπ receptor nuclear transl 184
452461 N78223 Hs 108106 transcnpdon factor 18 1
409395 U46745 Hs 54435 dystrobrevm, alpha 18 1
417183 R52089 Hs 172717 ESTs 180
409638 AW450420 Hs 21335 ESTs 180
428392 H10233 Hs 2265 secretory granule, neuroendocnne protei 180
449611 AI970394 Hs 197075 ESTs 170
446692 Z44514 Hs 156829 Homo sapiens mRNA for KIAA1763 protein. 169
425088 AA663372 Hs 169395 hypothedcal protein FU12015 169
444471 AB020684 Hs 11217 KIAA0877 protein 168
421659 NM 014459 Hs 106511 protocadhenn 17 167
431725 X65724 Hs 2839 Nome disease (pseudoglioma) 166
429276 AF056085 Hs 198612 G protein-coupled receptor 51 166
416892 L24498 Hs 80409 growth arrest and DNA-damage-iπducible, 165
441440 AI807981 Hs 30495 ESTs 157
449433 AI672096 Hs 9012 ESTs, Weakly similar to S26650 DNA-bmdi 15 7
421264 AL039123 Hs 103042 microtubule-associated protein 1B 155
415910 U20350 Hs 78913 chemokine (C-X3-C) receptor 1 153
413597 AW302885 Hs 117183 ESTs 15 1
424945 AI221919 Hs 173438 hypothedcal protein FU10582 149
447414 D82343 Hs 18551 neuroblastoma (nerve dssue) protein 149
426269 H15302 Hs 168950 Homo sapiens mRNA, cDNA DKFZp566A1046 (f 14 8
416857 AA188775 Hs 292453 ESTs 14 7
419721 NM 001650 Hs 288650 aquaponn 4 146
411078 AI222020 Hs 182364 CocoaCnsp 144
453924 R49295 Hs 24886 ESTs 144
409389 AB007979 Hs 301281 Homo sapiens mRNA, chromosome 1 specific 14 3
430130 AL137311 Hs 234074 Homo sapiens mRNA cDNA DKFZp761G02121 ( 14 1
410909 AW898161 Hs 53112 ESTs, Moderately similar to ALU8 HUMAN A 140
412266 N59006 Hs 26133 ESTs 140
412986 X81120 Hs 75110 cannabinoid receptor 1 (brain) 14 0
424790 AL119344 Hs 13326 ESTs, Weakly similar to 2004399A chromos 140
439239 AI031540 Hs 235331 ESTs 140
441497 R51064 Hs 23172 ESTs 140
445495 BE622641 Hs 38489 ESTs, Weakly similar to I38022 hypothed 140
414245 BE148072 Hs 75850 WAS protein family, member 1 137
429900 AA460421 Hs 30875 ESTs 136
448595 AB014544 Hs 21572 KIAA0644 gene product 136
449605 AW138581 Hs 198416 ESTs 136
452526 W38537 Hs 280740 hypothedcal protein MGC3040 13 6
420547 AF155140 Hs 98738 gonadotropin-regulated tesdcular RNA he 133
441350 AB020690 Hs 7782 paraneoplasdc andgen MA2 13 3
420077 AW512260 Hs 87767 ESTs 132
424120 T80579 Hs 290270 ESTs 13 2
456965 AW131888 Hs 172792 ESTs, Weakly similar to hypothetical pro 132
423361 AW170055 Hs 47628 ESTs 13 1
428409 AW117207 Hs 98523 ESTs 129
417160 N76497 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbac 126
451621 AI879148 Hs 26770 fatty acid binding protein 7 brain 12 5
411379 AI816344 Hs 12554 ESTs. Weakly similar to NPL4_HUMAN NUCLE 125
436954 AA740151 Hs 130425 ESTs 124
430691 C14187 Hs 103538 ESTs 124
433551 AI985544 Hs 12450 protocadheπn 9 124
422544 AB018259 Hs 118140 KIAA0716 gene product 122
427540 R12014 Hs 20976 ESTs 12 1
435624 AF218942 Hs 24889 formin 2 12 1
415849 R20529 Hs 6806 ESTs 12 1
428845 AL157579 Hs 153610 KIAA0751 gene product 11 9
442671 AI005668 Hs 134779 EST 11 9
444396 T65213 Hs 4257 ESTs 11 8
452752 AW044058 Hs 33578 KIAA0820 protein 11 8 425523 AB007948 Hs 158244 KIAA0479 protein 11 8
416072 AL110370 Hs 79000 growth associated protein 43 11 7
440184 AB002297 Hs 7022 dedicator of cyto-kmesis 3 11 7
428976 AL037824 Hs 194695 ras homolog gene family, member I 11 6
444783 AK001468 Hs 62180 anillin (Drosophila Scraps homolog), act 11 6
448299 AA497044 Hs 20887 hypothedcal protein FU 10392 11 6
414214 049958 Hs 75819 glycoprotein M6A 11 5
428982 NM_005097 Hs 194704 leucme-πch, glioma inacdvated 1 11 5
405238 11 4
420362 U79734 Hs 97206 hundngtin interacting protein 1 11 4
422980 N46569 Hs 76722 CCAAT/enhancer binding protein (C/EBP), 11 4
424918 R13982 Hs 169309 myelin-associated oligodendrocyte basic 11 4
434277 X77748 Hs 3786 glutamate receptor, metabotropic 3 11 4
451952 AL120173 Hs 301663 ESTs 11 3
408829 NM 006042 Hs 48384 heparan sulfate (glucosamme) 3-O-sulfot 11 3
424278 AKθ.0723 Hs 144517 hypothedcal protein FLJ20716 11 3
429418 AI381028 Hs 118769 ESTs 11 3
429918 AW873986 Hs 119383 ESTs 11 3
443912 R37257 Hs 184780 ESTs 11 3
448743 AB032962 Hs 21896 KIAA1136 protein 11 3
420092 AA814043 Hs 88045 ESTs 11 2
408081 AW451597 Hs 167409 ESTs 11 2
411642 NM 014932 Hs 71132 neuroligm 1 109
415170 R44386 Hs 164578 ESTs 109
426320 W47595 Hs 169300 transforming growth factor, beta 2 108
450568 AL050078 Hs 25159 Homo sapiens cDNA FU10784 (is, clone NT 108
425799 T08133 Hs 182906 Homo sapiens mRNA for KIAA1872 protein. 108
423853 AB011537 Hs 133466 slit (Drosophila) homolog 1 107
400293 N51002 Hs 306480 Homo sapiens mRNA, cDNA DKFZp761E2112 (f 107
447773 AI423930 Hs 36790 ESTs, Weakly similar to putadve p150 (H 107
448321 NM_005883 Hs 20912 adenomatous polyposis cod like 105
448533 AL119710 Hs 21365 nucleosome assembly protein 1-lιke 3 105
440684 AI253123 Hs 127356 ESTs, Highly similar to S21424 nesdn [H 103
444017 U04840 Hs 214 neuro-oncological ventral andgen 1 10 3
438380 T06430 Hs 6194 chondroidn sulfate proteoglycan BEHAB/b 103
440471 AA886146 Hs 307944 ESTs 102
413063 AL035737 Hs 75184 chidnase 3-lιke 1 (cartilage glycoprote 10 1
439978 BE139460 Hs 124673 Homo sapiens cDNA FLJ 11477 fis, clone HE 10 1
448902 Z45998 Hs 22543 Homo sapiens mRNA, cDNA DKFZp761M912 (f 101
424932 R14070 Hs 315369 Homo sapiens cDNA FU23075 fis, clone L 99
431721 AB032996 Hs 268044 KIAA1170 protein 99
419088 AI538323 Hs 52620 integnn, beta 8 98
420602 AF060877 Hs 99236 regulator of G-protem signalling 20 98
436511 AA721252 Hs 291502 ESTs 98
414696 AF0O2020 Hs 76918 Niemann-Pick disease, type C1 97
449539 W80363 Hs 58446 ESTs 97
412959 D87458 Hs 75090 KIAA0282 protein 96
412811 H06382 Hs 21400 ESTs 96
449300 AI656959 Hs 222165 ESTs 96
426344 H41821 Hs 322469 transcπpdonal acdvator of the c-fos p 95
419271 N34901 Hs 238532 ESTs 95
419078 M93119 Hs 89584 ιnsulιnoma-3Ssocιated 1 94
451516 AI800515 Hs 12024 ESTs 94
422656 AI870435 Hs 1569 LIM homeobox protein 2 93
449318 AW236021 Hs 78531 Homo sapiens, Similar to RIKEN cDNA 5730 93
414175 AI308876 Hs 103849 hypothetical protein DKFZp761D112 93
415279 F04237 Hs 1447 glial fibnllary acidic protein 92
428784 Y12851 Hs 193470 punnergic receptor P2X, ligand-gated 92
429903 AL134197 Hs 93597 cyclm-dependent kinase 5, regulatory su 92
424641 AB001106 Hs 151413 glia maturation factor, beta 9 1
417435 NM 005181 Hs 82129 carbonic anhydrase III muscle specific 91
449448 D60730 Hs 57471 ESTs 91
408508 AI806109 Hs 135736 KIAA1580 protein 90
452785 AL359942 Hs 296434 erythroid differentiation and denuclead 90
448986 H42169 Hs 18653 hypothedcal protein FLJ14627 89
447072 061594 Hs 17279 tyrosylprotem sulfotransferase 1 89
433800 AI034361 Hs 135150 lung type-l cell membrane-associated gly 89
408926 AF21 525 Hs 49002 Down syndrome cell adhesion molecule 88
449625 NM 014253 Hs 23796 odz (odd OzΛen-m. Drosophila) homolog 1 88
400292 AA250737 Hs 72472 ESTs 87
417404 NM_0O7350 Hs 82101 pleckstnn homology-like domain, family 87
420345 AW295230 Hs 25231 ESTs 87
429927 NM_001115 Hs 2522 adenylate cyclase 8 (brain) 87
437528 N59646 Hs 169745 crumbs (Drosophila) homolog 1 87
440152 AB002376 Hs 7006 KIAA0378 protein 87
451099 R52795 Hs 25954 mtedeukin 13 receptor, alpha 2 86
400780 86
434891 AA814309 Hs 123583 ESTs 86
449277 AA001064 Hs 172976 ESTs 86
415709 AA649850 Hs 278558 ESTs 85
439947 AB006627 Hs 6788 astrotacdn 85
447197 R36075 gb yh88b01 s1 Soares placenta Nb2HP Homo 85
433042 AW193534 Hs 281895 Homo sapiens cDNA FU11660 fis, clone HE 84 416370 N90470 Hs 203697 ESTs, Weakly similar to 138022 hypothed 84
452786 R61362 Hs 106642 ESTs, Weakly similar to T09052 hypothed 84
415796 R87548 Hs 78854 ATPase, Na+/K- transporting beta 2 poly 83
426271 AF026547 Hs 169047 chondroidn sulfate proteoglycan 3 (neur 83
408947 AL080093 Hs 49117 Homo sapiens mRNA, cDNA DKFZp564N1662 (f 83
419863 AW952691 Hs 93485 Homo sapiens mRNA, cDNA DKFZp761D191 (fr 83
433447 U29195 Hs 3281 neuronal pentraxin II 83
431467 N71831 Hs 256398 Homo sapiens mRNA, cONA DKFZp434E0528 (f 83
409327 L41162 Hs 53563 collagen, type IX, alpha 3 83
414300 Al304870 Hs 188680 ESTs 82
407728 AW071502 Hs 175931 ESTs 82
422798 R92347 Hs 34574 ESTs, Weakly similar to ALU1_HUMAN ALU S 82
419704 AA429104 Hs 45057 ESTs 82
429007 D80642 gb HUM092E09B Human fetal brain (TFu|iwa 81
442710 AI015631 Hs 23210 ESTs 81
425048 H05468 Hs 164502 ESTs 81
429149 AW193360 Hs 197962 ESTs, Weakly similar to I38022 hypothed 80
445740 T78281 Hs 13226 Homo sapiens done 25181 mRNA sequence 80
418771 AA807881 Hs 25329 ESTs 79
422728 AW937826 Hs 103262 ESTs, Weakly similar to ZN91.HUMAN ZINC 79
425984 AW836277 Hs 165636 hypothedcal protein DKFZp761C07121 79
448408 AA322866 Hs 21107 neuroligin 79
455364 H72176 Hs4273 hypothedcal protein FU13159 79
446619 AU076643 Hs313 secreted phosphoprotein 1 (osteopondn, 79
435501 AW051819 Hs 129908 KIAA0591 protein 78
423600 AI633559 Hs 310359 ESTs 78
450625 AW970107 gb EST382188 MAGE resequences, MAGK Homo 78
415314 N88802 Hs5422 glycoprotein M6B 77
420036 R60336 Hs 52792 Homo sapiens mRNA, cDNA DKFZp586l1823 (f 77
427687 AW003867 Hs 1570 histamine receptor H1 77
449328 AI962493 Hs 197647 ESTs 77
419249 X14767 Hs 89768 gamma-aminobutync acid (GABA) A recepto 77
407896 D76435 Hs 41154 Zic family member 1 (odd-paired Drosophi 77
419103 Z40229 Hs96423 hypothedcal protein FU 23033 76
438779 NM.003787 Hs 6414 nucleolar protein 4 76
433532 AW975367 gb EST387475 MAGE resequences, MAGN Homo 76
448555 AI536697 Hs 159863 ESTs 75
439662 H97552 Hs 269060 ESTs 75
448543 AW897741 Hs 21380 Homo sapiens mRNA, cDNA DKFZp586P1124 (f 75
410099 AA081630 Hs 169387 KIAA0036 gene product 75
431592 R69016 Hs 213194 hypothetical protein MGC10895 74
409731 AA125985 Hs 56145 thymosin, beta, identified in neuroblast 74
405819 74
407886 AW969688 Hs 100826 ESTs 74
437416 AL359605 Hs 283851 Homo sapiens mRNA, cDNA DKFZp547G036 (fr 74
437698 R61837 Hs 7990 ESTs, Moderately similar to I84505 calci 74
408604 D51408 Hs 21925 ESTs 74
418506 AA084248 Hs 85339 G protein-coupled receptor 39 73
447499 AW262580 Hs 147674 protocadheπn beta 16 73
454036 AA374756 Hs93560 Homo sapiens mRNA for KIAA1771 protein, 73
409746 NM_004794 Hs 56294 RAB33A, member RAS oncogene family 72
410037 AB020725 Hs 58009 KIAA0918 protein 72
419318 AW969742 Hs 291005 ESTs 72
424051 AU10203 Hs 138411 Homo sapiens mRNA, cDNA DKFZp586J1922 (f 72
442026 AI243749 Hs 8074 brain-specific angiogenesis inhibitor 3 72
448243 AW369771 Hs 52620 integnn, beta 8 72
436281 AW411194 Hs 85195 myeloid leukemia factor 1 72
426429 X73114 Hs 169849 myosin-binding protein C, slow-type 72
4Q7182 AA312551 Hs 230157 ESTs 71
415293 R49462 Hs 106541 ESTs 71
422764 AI767727 Hs 47522 ESTs 71
451592 AI805416 Hs 213897 ESTs 71
429469 M64590 Hs27 glycine dehydrogenase (decarboxyladng, 70
415734 NM 014747 Hs 78748 KIAA0237 gene product 70
434149 Z43829 Hs 19574 hypothedcal protein MGC5469 70
436726 AA324975 Hs 128993 ESTs, Weakly similar to T00079 hypotheti 70
417632 R20855 Hs 5422 glycoprotein M6B 70
422421 AA325138 Hs 235873 hypothedcal protein FU22672 69
435267 N23797 Hs 110114 ESTs 69
437117 AL049256 Hs 122593 ESTs 69
445523 230118 Hs 293788 ESTs, Moderately similar to unnamed prot 69
445900 AF070526 Hs 13429 Homo sapiens clone 24787 mRNA sequence 69
445745 AB007924 Hs 13245 KIAA0455 gene product 69
424085 NM 002914 Hs 139226 replicadon factor C (acdvator 1) 2 (40 69
428588 F12101 Hs 185701 Homo sapiens mRNA full length insert cDN 68
421723 AA620400 Hs 300717 sodium channel, voltage gated, type III, 68
447342 AI199268 Hs 19322 Homo sapiens, Similar to RIKEN cDNA 2010 67
443297 AI049864 Hs 133029 ESTs 67
443992 AW022228 Hs 322922 ESTs 67
453096 AW294631 Hs 11325 ESTs 67
453857 AL080235 Hs 35861 DKFZP586E1621 protein 67
443761 AI525743 Hs 160603 ESTs 66
429609 AF002246 Hs 210863 cell adhesion molecule with homology to 66 435056 AW023337 HS 5422 glycoprotein M6B 65
453431 AF094754 Hs 32973 glycine receptor, beta 65
444190 AI878918 Hs 10526 cysteine and glycine-πch protein 2 65
418110 R43523 Hs 217754 hypothedcal protein FU22202 65
413988 M81883 Hs 324784 glutamate decarboxylase 1 (brain, 67kD) 65
420805 L10333 Hs 99947 redculon 1 64
429125 AA446854 Hs 271004 ESTs, Weakly similar to I38022 hypothed 64
435256 AF193766 Hs 13872 cytokine-like protem C1 64
407866 AW088232 Hs 89506 paired box gene 6 (aniπdia, keradds) 63
440700 AW952281 Hs 296184 guanine nudeodde binding protein (G pr 63
427701 AA411101 Hs 243886 nuclear autoandgenic sperm protein (his 63
422949 AA319435 gb EST21657 Adrenal gland tumor Homo sap 62
445102 AW204610 Hs 22270 ESTs 62
452401 NM 007115 Hs 29352 tumor necrosis factor, alpha-induced pro 62
435538 AB011540 Hs 4930 low density lipoprotein receptor-related 62
410102 AW248508 Hs 279727 Homo sapiens cDNA FU 14035 fis, clone HE 62
416871 H98716 gb yx13d08 s1 Soares melanocyte 2NbHM Ho 6 1
416702 AA186428 Hs 85591 ESTs 6 1
419347 C15944 Hs 90005 supeπorcervical ganglia, neural spectfi 6 1
424997 AL138167 Hs 96920 ESTs 6 1
438660 U95740 Hs 6349 Homo sapiens, clone IMAGE 3010666, mRNA, 61
453649 Y07494 Hs 34114 ATPase, Na+/K+ transporting, alpha 2 (+) 61
449444 AW818436 Hs 23590 solute earner family 16 (monocarboxylic 61
414117 W88559 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbac 60
425517 AF121179 gb AF121179 Homo sapiens liver (Chang L- 60
427457 AW779105 Hs 164682 ESTs 60
437034 AA742643 gb ny91c01 s1 NCI CGAP GCB1 Homo sapiens 60
444170 AW613879 Hs 102408 ESTs 60
457183 H91882 Hs 118569 Dvl-bind g protein IDAX (inhibition of 60
448999 AF179274 Hs 22791 transmembrane protein with EGF-hke and 60
454048 H05626 Hs 6921 ESTs 60
439772 AL365406 Hs 10268 Homo sapiens mRNA full length insert cDN 59
448944 AB014605 Hs 22599 atrophιn-1 interacting protein 1, acdvi 59
410011 AB020641 Hs 57856 PFTAIRE protein kinase 1 59
415486 H12214 Hs 13284 ESTs, Weakly similar to 2109260A B cell 59
438993 AA828995 gb od77b08 s1 NCI CGAP Ov2 Homo sapiens 59
447350 AI375572 Hs 172634 ESTs 59
451783 R42554 Hs 210862 T-box, brain, 1 59
447101 N72185 Hs 44189 ESTs 59
440492 R39127 Hs 21433 hypothedcal protein DKFZp547J036 59
440274 R24595 Hs 7122 scrapie responsive protein 1 59
438461 AW075485 Hs 286049 phosphoseπne aminotransferase 59
418064 BE387287 Hs 83384 S100 calcium-binding protein, beta (neur 58
437036 AI571514 Hs 133022 ESTs 57
412225 AW902042 gb QVO-NN1022-170400-193-Λ2 NN1022 Homo 57
426342 AF093419 Hs 169378 muldple PDZ domain protein 57
444218 AF070641 Hs 10684 Homo sapiens clone 24421 mRNA sequence 57
445828 F05802 Hs 81907 ESTs 57
447198 D61523 Hs 283435 ESTs 57
427897 NM 017413 Hs 303084 apelm, pepdde ligand for APJ receptor 57
448499 BE613280 Hs 77550 hypothedcal protein MGC1780 57
443672 AA323362 Hs 9667 butyrobeta e (gamma), 2-oxoglutarate di 56
412155 R38167 Hs 12449 Homo sapiens transmembrane protein HTMP1 56
435718 R06569 Hs 269534 ESTs 56
449340 AW235786 Hs 195359 hypothedcal protein MGC10954 56
424481 R19453 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbac 56
451996 AW514021 Hs 245510 ESTs 56
422411 AW749443 Hs 22511 ESTs 56
438328 AI492261 Hs 32450 ESTs 56
433244 AB040943 Hs 271285 KIAA1510 protein 56
435191 R15912 Hs 4817 Homo sapiens clone 24461 mRNA sequence 55
418677 S83308 Hs 87224 SRY (sex determining region Y)-box 5 55
400859 55
413625 AW451103 Hs 71371 ESTs 55
421863 AI952677 Hs 108972 Homo sapiens mRNA, cDNA DKFZp434P228 (fr 55
434933 R91095 Hs 4276 KIAA1701 protein 55
438702 AI879064 Hs 54618 ESTs 55
452055 AI377431 Hs 141693 hypothedcal protein MGC10858 55
430979 AI479755 Hs 129010 ESTs 55
412709 AL022327 Hs 74518 KIAA0027 protein 55
439920 H05430 Hs 288433 neurotπmin 55
424343 AW956360 Hs 4748 adenylate cyclase activating polypepdde 54
407846 AA426202 Hs 40403 Cbp/p300-ιnteractιng transacdvator, wit 54
419235 AW470411 Hs 288433 neurotπmin 54
418030 BE207573 Hs 83321 neuromedm B 54
410330 AW023630 Hs 46786 ESTs 54
410781 AI375672 Hs 165028 ESTs 54
420658 AW965215 Hs 336656 ESTs 54
421308 AA687322 Hs 192843 leucine zipper protein FKSG14 54
443740 R56434 Hs 21062 ESTs 54
426457 AW894667 Hs 169965 chimeπn (chimaenn) 1 54
450375 AA009647 Hs 8850 a dismtegnn and metalloproteinase doma 54
412494 AL133900 Hs 792 ADP-πbosylation factor domain protem 1 54 426600 NM 003378 Hs 171014 VGF neive growth factor inducible 54
424432 AB037821 Hs 146858 protocadhenn 10 54
429250 H56585 Hs 198308 tryptophan nch basic protein 54
443785 AW449952 Hs 190125 basic-helix-loop-helix-PAS protein 54
436282 R91913 Hs 272104 ESTs, Moderately similar to ALU1.HUMAN A 54
404584 53
430091 AB032958 Hs 233023 KIAA1132 protein 53
439845 AL355743 Hs 56663 Homo sapiens EST from clone 41214, full 53
424001 W67883 Hs 137476 paternally expressed 10 53
425073 W39609 Hs 22003 solute earner family 6 (neurotransmitte 53
426625 T78300 Hs 300642 serologically defined colon cancer andg 53
428137 AA421792 Hs 170999 ESTs 53
428679 AA431765 gb zw80c03 s1 Soares tesds NHT Homo sap 53
438176 AW138970 Hs 122113 ESTs 53
440138 AB033023 Hs 318127 hypothedcal protein FU10201 53
451018 AW965599 Hs 247324 mitochondπal πbosomal protein S14 53
416340 N31772 Hs 79226 fasciculadon and elongation protein zet 53
435244 N77221 Hs 187824 ESTs 53
446035 NM 006558 Hs 13565 Sam68-lιke phosphotyrosine protein, T-ST 53
424624 AB032947 Hs 151301 Ca2- lependent acdvator protein for sec 53
407748 AL079409 Hs 38176 KIAA0606 protein, SCN Orcadian Oscillat 53
430437 AI768801 Hs 169943 Homo sapiens cDNA FU13569 fis, clone PL 53
414825 X06370 Hs 77432 epidermal growth factor receptor (avian 52
453941 U39817 Hs 36820 Bloom syndrome 52
424998 U58515 Hs 154138 chi nase 3-lιke 2 52
423419 R55336 Hs 23539 ESTs 52
424922 BE386547 Hs 217112 hypothetical protein MGC10825 52
447359 NM 012093 Hs 18268 adenylate kinase 5 52
408206 AF041853 Hs 43670 kinesin family member 3A 52
421013 M62397 Hs 1345 mutated in colorectal cancers 52
429443 AB028967 Hs 202687 potassium voltage-gated channel, Shal re 52
434367 AB020700 Hs 3830 KIAA0893 protein 52
444861 R46789 Hs 76118 ubiquitin carboxyl-terminal esterase L1 52
446142 AI754693 Hs 145968 ESTs 52
448816 AB033052 Hs 22151 KIAA1226 protein 52
451050 AW937420 Hs 69662 ESTs 52
451106 BE382701 Hs 25960 v-myc avian myelocytomatosis viral relat 52
439285 AL133916 Hs 172572 hypothedcal protein FU20093 52
416737 AF154335 Hs 79691 LIM domain protein 52
424800 AL035588 Hs 153203 MyoD family inhibitor 52
443695 AW204099 Hs 337720 ESTs, Weakly similar to AF126780 1 redn 52
415257 F03016 Hs 27513 ESTs 52
433929 AI375499 Hs 27379 ESTs 5 1
415651 AI207162 Hs 3815 stathmin-like-protein RB3 5 1
451027 AW519204 Hs 40808 ESTs 51
409172 Z99399 Hs 118145 ESTs 5 1
423343 AA324643 Hs 246106 ESTs 5 1
429172 AA447417 Hs 285491 ESTs 5 1
437268 AI754847 Hs 227571 regulator of G-protem signalling 4 5 1
451270 AW341392 Hs 235795 ESTs 5 1
452904 AL157581 Hs 30957 Homo sapiens mRNA, cDNA DKFZp434E0626 (f 5 1
420560 AW207748 Hs 59115 ESTs 5 1
418097 R45137 Hs 21868 ESTs 5 1
442910 AI365130 Hs 11307 ESTs, Weakly similar to T19326 hypothed 5 1
434849 AW292765 Hs 8053 ESTs 5 1
413554 AA319146 Hs 75426 secretogranm II (chromogranin C) 5 1
414217 AI309298 Hs 279898 Homo sapiens cDNA FU23165 fis, clone L 5 1
412068 S72043 Hs 73133 metallothionein 3 (growth inhibitory fac 50
413627 BE182082 Hs 246973 ESTs 50
418661 NM 001949 Hs 1189 E2F transcnpdon factor 3 50
422438 AA445925 Hs 270896 ESTs, Moderately similar to Z195_HUMAN Z 50
423728 AW891294 Hs 132136 solute earner family 4, sodium bicarbon 50
431431 AL096711 Hs 252953 Human DNA sequence from clone RP3-403A15 50
435087 AW975241 Hs 23567 ESTs 50
452097 AB002364 Hs 27916 a dismtegπn-like and metalloprotease ( 50
410434 AF051152 Hs 63668 toll-like receptor 2 49
408692 AL040127 Hs 34074 dipeptidylpepddaseVI 49
407808 AA663559 Hs 279789 histone deacetylase 3 49
418940 H17739 Hs 288513 Human DNA sequence from clone RP5-899C14 49
425977 R15138 Hs 165570 Homo sapiens clone 25052 mRNA sequence 49
426814 AF036943 Hs 172619 myelin transcnpdon factor 1 -tike 49
447112 H17800 HS 154 ESTs 49
449574 F05048 Hs 175373 ESTs 49
453652 AW009640 Hs 28368 ESTs, Moderately similar to S65657 alpha 49
423869 BE409301 Hs 134012 C1q-related factor 49
413248 T64858 Hs 21433 hypothedcal protein DKFZp547J036 49
449176 AI633545 Hs 198072 ESTs 49
448451 AW015994 gb UI-H-BIOp-abh-g-09-O-UI s1 NCLCGAP.S 48
402604 48
436039 AW023323 Hs 121070 ESTs 48
448769 N66037 Hs 38173 ESTs 48
423678 AW963357 Hs 7847 ESTs 48
439451 AF086270 Hs 278554 heterochromadn-like protein 1 48 425870 R13406 Hs 56782 ESTs 48
408777 U71204 Hs 47626 Ric (Drosophila) like expressed in neur 48
413409 AI638418 Hs 78580 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 48
413623 AA825721 Hs 246973 ESTs 48
417246 AI760098 Hs 21411 ESTs 48
420900 AL045633 Hs 44269 ESTs 48
424153 AA451737 Hs 141496 MAGE-like 2 48
443539 AI076182 Hs 134074 ESTs, Moderately similar to ALU6_HUMAN A 48
448750 U95020 Hs 21903 calcium channel, voltage-dependent beta 48
454030 AW021429 Hs 231980 ESTs 48
424458 M29273 Hs 1780 myelin associated glycoprotein 48
444119 R41231 Hs 184261 ESTs, Weakly similar to T26686 hypothed 48
407792 AI077715 Hs 39384 putadve secreted ligand homologous to f 48
431462 AW583672 Hs 256311 granin-like neuroendocnne pepdde precu 47
431103 M57399 Hs 44 pleiotrophin (hepann binding growth tac 47
429956 AI374651 Hs 22542 ESTs 47
435060 AI422719 Hs 233349 ESTs, Weakly similar to fork head like p 4 7
436203 BE384982 Hs 5076 Homo sapiens cDNA FU22128 fis, clone H 47
448475 BE613134 Hs 247474 hypothetical protein FU21032 47
422222 AI699372 Hs 193247 hypothedcal protein DKFZp434A171 47
431733 AW298410 Hs 21475 ESTs 47
449353 AA001220 Hs 271369 ESTs 47
452022 AW072330 Hs 293875 ESTs 47
454269 AI961060 Hs 129908 KIAA0591 protein 47
404541 47
428189 AA424030 Hs 46627 ESTs 47
409125 R17268 Hs 259873 axonal transport of synapdc vesicles 47
458435 AI418718 Hs 144121 ESTs, Weakly similar to T46916 hypothed 46
425745 U44060 Hs 14427 Homo sapiens cDNA FU21800 fis, clone H 46
413492 D87470 Hs 75400 KIAA0280 protein 46
419629 AB020695 Hs 91662 KIAA0888 protein 46
407638 AJ404672 Hs 334483 hypothedcal protein FU23571 46
436140 W87355 Hs 269587 ESTs 46
439169 AI912122 Hs 41095 ESTs 46
443150 AI034467 Hs 34650 ESTs 46
451073 AI758905 Hs 206063 ESTs 46
451659 BE379761 Hs 14248 ESTs 46
452106 AI141031 Hs 21342 ESTs 46
451407 AA131376 Hs 326401 fibroblast growth factor 12B 46
448765 R15337 Hs 21958 Homo sapiens mRNA, cDNA DKFZp547D086 (fr 46
430147 R60704 Hs 234434 hairy/enhancer-of-spht related with YRP 46
437204 AL110216 Hs 12285 ESTs, Weakly similar to 155214 salivary 46
431117 AF003522 Hs 250500 delta (Drosophιla)-lιke 1 45
422175 N79885 Hs 6382 ESTs, Highly similar to T00391 hypothed 45
407889 R34556 Hs 30800 ESTs, Weakly similar to S65657 alpha-1 C- 45
419343 AA456245 Hs 85603 down regulated by Ctnnbl, a 45
421790 AW896201 Hs 22654 sodium channel, voltage-gated, type 1, a 45
429399 AA452244 Hs 16727 ESTs 45
450149 AW969781 Hs 132863 Zic family member 2 (odd-paired Drosophi 45
453118 AW195849 Hs 252757 ESTs 45
443455 AB001025 Hs 9349 ryanodme receptor 3 44
442613 AI004002 Hs 130522 Kv channel interacdng protein 1 44
429643 AA455889 Hs 167279 FYVE-finger-containing Rab5 effector pro 44
416209 AA236776 Hs 79078 MAD2 (mitodc aπest deficient, yeast, h 44
418845 AA852985 Hs 89232 chromobox homolog 5 (Drosophila HP1 alph 44
435202 AI971313 Hs 170204 KIAA0551 protein 44
437496 AA452378 Hs 170144 Homo sapiens mRNA, cDNA DKFZp547J125 (fr 44
451254 AI571016 Hs 172967 ESTs 44
439039 AI656707 Hs 48713 ESTs 44
439979 AW600291 Hs 6823 hypothedcal protein FU10430 44
441607 NM 005010 Hs 7912 neuronal cell adhesion molecule 44
424983 AI742434 Hs 169911 ESTs 44
410611 AW954134 Hs 20924 KIAA1628 protein 44
402605 44
409248 AB033035 Hs 51965 KIAA1209 protein 44
442222 AI061301 Hs 164773 ESTs 44
454027 R40192 Hs 21527 Human DNA sequence from clone GS1-115M3 44
454293 H49739 Hs 134013 ESTs, Moderately similar to HK61 HUMAN H 44
442832 AW206560 Hs 253569 ESTs 44
407304 AA565832 gb n|32b03 s1 NCI CGAP AA1 Homo sapiens 44
423279 AW959861 Hs 290943 ESTs 43
427194 AA399018 Hs 250835 ESTs 43
419723 AL120193 Hs 92614 longevity assurance (LAG1, S cerevisiae 43
445810 AW265700 Hs 155660 ESTs 43
409734 BE161664 Hs 56155 hypothedcal protein 43
410389 AW954049 Hs 8177 ESTs, Weakly similar to PIHUB6 salivary 43
411571 AA122393 Hs 70811 hypothedcal protein FLJ20516 43
433024 AA573847 Hs 26549 KIAA1708 protein 43
453202 AW085781 Hs 26270 hypothedcal protein FLJ 11588 43
425264 AA353953 Hs 20369 ESTs, Weakly similar to gonadotropin ind 43
416427 BE244050 Hs 79307 Rac/Cdc42 guanine exchange factor (GEF) 43
431789 H19500 Hs 269222 mitogen-acdvated protein kinase 4 43
444600 R41398 Hs 6996 ESTs 43 454042 H22570 Hs 172572 hypothetical protein FU20093 43
441899 AI372588 Hs 8022 TU3A protein 43
425256 BE297611 Hs 155392 collapsin response mediator protein 1 43
410358 AW975168 Hs 13337 ESTs, Weakly similar to unnamed protein 42
430291 AV660345 Hs 238126 CGI-49 protein 42
433597 AA708205 Hs 100343 ESTs 42
444127 N63620 Hs 13281 ESTs 42
448507 AL133109 Hs 21333 Homo sapiens mRNA, cDNA DKFZp566N1047 (f 42
413589 AW452631 Hs 313803 ESTs, Highly similar to AF157833 1 noncl 42
408577 H50572 Hs 19515 ESTs, Highly similar to NRG3.HUMAN PRO-N 42
409719 AI769160 Hs 108681 Homo sapiens brain tumor associated prot 42
428536 AI143139 Hs 2288 visinm-like 1 42
429118 H20669 Hs 35406 ESTs, Highly similar to unnamed protein 42
432865 AI753709 Hs 152484 ESTs, Weakly similar to I38022 hypothed 42
447138 AI439112 Hs 93828 ESTs, Weakly similar to 2109260A B cell 42
450648 AI703366 Hs 26766 ESTs 42
451459 AI797515 Hs 270560 ESTs, Moderately similar to ALU7_HUMAN A 42
421686 AB011156 Hs 106794 KIAA0584 protein 42
452776 AA194540 Hs 13522 ESTs, Weakly similar to I38022 hypothed 42
436421 AI678031 Hs 122813 ESTs, Weakly similar to ZN22.HUMAN ZINC 42
423858 AL137326 Hs 133483 Homo sapiens mRNA, cDNA DKFZp434B0650 (f 42
434001 AW950905 Hs 3697 senne (or cysteine) proteinase inhibito 42
437380 AL359577 Hs 112198 Homo sapiens mRNA, cDNA DKFZp547M073 (fr 42
432328 AI572739 Hs 195471 6-phosphofructo-2-kιπase/fructose-2,6-bι 4 1
439607 BE540565 Hs 159460 ESTs 41
424028 AF055084 Hs 153692 Homo sapiens cDNA FU 14354 fis, done Y7 4 1
446936 H10207 Hs 47314 ESTs 4 1
424240 AB023185 Hs 143535 calcium/calmodulin-depεπdent protein km 41
412446 AI768015 Hs 92127 ESTs 41
409953 AA332277 Hs 57691 cadheπn 18, type 2 4 1
416220 N49776 Hs 170994 hypothedcal protein MGC10946 41
419683 AA248897 Hs 48784 ESTs 41
426071 AW138057 Hs 163835 ESTs 4 1
428743 AL080060 Hs 301549 Homo sapiens mRNA, cDNA DKFZp564H172 (fr 41
432809 AA565509 Hs 131703 ESTs 41
440105 AA694010 Hs 6932 Homo sapiens clone 23809 mRNA sequence 4 1
452039 AI922988 Hs 172510 ESTs 4 1
425905 AB032959 Hs 318584 novel C3HC4 type Zinc finger (πng finge 41
457561 AA331517 Hs 286055 chimenn (chimaeπn) 2 4 1
429038 AL023513 Hs 194766 seizure related gene 6 (mouse) like 41
433932 AW954599 Hs 169330 neuronal protein 41
436637 AI783629 Hs 26766 ESTs 4 1
439231 AW581935 Hs 141480 Homo sapiens mRNA, cDNA DKFZp434N079 (fr 41
450530 NM 006668 Hs 25121 cytochrome P450, subfamily 46 (cholester 41
407721 Y12735 Hs 38018 dual-specificity tyrosιne-(Y)-phosphoryl 4 1
407881 AW072003 Hs 40968 heparan sulfate (glucosamine) 3-O-sulfot 4 1
410486 AW235094 Hs 69233 zinc finger protein 40
413916 N49813 Hs 75615 apolipoprotein C-ll 40
438703 AI803373 Hs31599 ESTs 40
424726 AK001007 Hs 138760 Homo sapiens cDNA FU10145 fis, clone HE 40
405771 40
418841 NM_002332 Hs 89137 low density lipoprotein-related protein 40
421764 AI681535 Hs 148135 senne/threonine kinase 33 40
424176 AL137273 Hs 142307 hypothetical protein 40
425773 N21279 Hs 237749 ESTs 40
427304 AA761526 Hs 163853 ESTs 40
428882 AA436915 Hs 131748 ESTs, Moderately similar to ALU7.HUMAN A 40
452834 AI638627 Hs 105685 KIAA1688 protein 40
453745 AA952989 Hs 63908 hypothedcal protein MGC14726 40
405239 U89281 Hs 11958 oxidadve 3 alpha hydroxysteroid dehydro 40
413801 M62246 Hs 35406 ESTs, Highly similar to unnamed protein 40
429698 AI685086 Hs 26339 ESTs, Weakly similar to S21348 probable 40
435854 AJ278120 Hs 4996 putadve ankynn-repeat containing prote 40
439199 R40373 Hs 26299 ESTs 40
439450 R51613 Hs 125304 ESTs 40
446782 AI653048 Hs 144006 ESTs 40
419687 AI638859 Hs 227699 ESTs, Weakly similar to T2D3 HUMAN TRANS 39
402408 39
453362 H14988 Hs 107375 ESTs 39
414219 W20010 Hs 75823 ALL1-fused gene from chromosome 1q 39
420578 AA813546 Hs 99034 GTP-binding protein Rho7 39
425010 T16837 Hs 4241 ESTs 39
444230 H95537 Hs 146067 ESTs 39
441736 AW292779 Hs 169799 ESTs 39
418951 F07809 Hs 89506 paired box gene 6 (anindia, keradds) 39
406311 39
408460 AA054726 Hs 285574 ESTs 39
410658 AW105231 Hs 192035 ESTs 39
414699 AI815523 Hs 76930 synuclein. alpha (non A4 component of am 39
418849 AW474547 Hs 53565 Homo sapiens PIG-M mRNA for maπnosyltran 39
429477 AI275514 Hs 6658 ESTs 39
433766 AA609234 Hs 112669 ESTs 39
436190 AK0O1059 gb Homo sapiens cDNA FU10197 fis, clone 39 447891 R41754 Hs 6496 ESTs 39
450221 AA328102 Hs 24641 cytoskeleton associated protein 2 39
404283 39
453919 AW959912 Hs 7076 KIAA1705 protein 39
429656 X05608 Hs 211584 neurofilament, light polypeptide (68kD) 39
412754 AW160375 Hs 74565 amyloid beta (A4) precursor-like protein 39
445314 AI689948 Hs 65489 Homo sapiens cDNA FU21517 fis, clone C 39
435652 N32388 Hs 334370 uncharacteπzed hypothalamus protein HBE 39
407378 AA299264 Hs 57776 ESTs, Moderately similar to I38022 hypot 39
438054 AA776626 Hs 62183 ESTs 39
436420 AA443966 Hs 31595 ESTs 39
445133 AW157646 Hs 153506 ESTs 39
432590 AI609273 Hs 110783 ESTs 39
453331 AI240665 Hs 8895 ESTs 39
410227 AB009284 Hs 61152 exostoses (muldple)-lιke 2 38
424635 AA420687 Hs 115455 Homo sapiens cDNA FU 14259 fis, clone PL 38
451489 NM 005503 Hs 26468 amyloid beta (A4) precursor protein-bind 38
447247 AW369351 Hs 287955 Homo sapiens cDNA FU 13090 fis, done NT 38
448302 AI480208 Hs 182906 Homo sapiens mRNA for KIAA1872 protein, 38
415669 NM 005025 Hs 78589 senne (or cysteine) proteinase inhitxto 38
417355 D13168 Hs 82002 endothelin receptor type B 38
446727 AB011095 Hs 16032 KIAA0523 protein 38
424340 AA339036 Hs 7033 ESTs 38
423346 AI267677 Hs 127416 synaptoianin 1 38
412788 AA120960 Hs 198416 ESTs 38
404593 38
416856 N27833 Hs 269028 ESTs, Weakly similar to I38022 hypothed 38
429896 AA460367 Hs 224223 ESTs, Moderately similar to I38022 hypot 38
439619 AW975998 Hs 58595 ESTs, Weakly similar to 138022 hypothed 38
439634 W79377 Hs 167 microtubule-associated protein 2 38
440322 AA879430 gb O)91d08 s1 Soares_NFL_T_GBC_S1 Homo s 38
447761 AF061573 Hs 19492 protocadheπn 8 38
452453 AI902519 gb QV-BT009-101198-051 BT009 Homo sapien 38
439671 AW162840 Hs 6641 kinesin family member 5C 38
447937 AL109716 Hs 20034 Homo sapiens mRNA full length insert cDN 38
459278 AW294659 Hs 34054 Homo sapiens cDNA FU22488 fis, clone H 38
447028 AI973128 Hs 167257 brain link proteιn-1 38
449458 AI805078 Hs 208261 ESTs 38
445888 AF070564 Hs 13415 Homo sapiens clone 24571 mRNA sequence 38
407385 AA610150 Hs 272072 ESTs, Weakly similar to I38022 hypothed 38
428841 AI418430 Hs 104935 ESTs 38
430643 AW970065 Hs 287425 MEGF10 protein 38
422263 AA307639 Hs 129908 KIAA0591 protein 38
451625 R56793 Hs 106576 alamne-glyoxylate aminotransferase 2-lι 38
439236 BE160952 Hs 247117 ESTs, Moderately similar to ALUF HUMAN ι 38
441928 AI370188 Hs 211454 ESTs 38
441797 AI936933 Hs 214635 ESTs 37
414922 D00723 Hs 77631 glycine cleavage system protein H (ammo 37
425588 F07396 Hs 46751 ESTs 37
437007 AA741300 Hs 202599 ESTs, Weakly similar to I38022 hypothed 37
435793 AB037734 Hs 4993 KIAA1313 protein 37
443682 AI383061 Hs 47248 ESTs, Highly similar to similar to Cdc14 37
425741 AF052152 Hs 159412 Homo sapiens clone 24628 mRNA sequence 37
418211 BE244746 Hs 247474 hypothedcal protein FU21032 37
440080 AW051597 Hs 143707 ESTs 37
452898 AA814497 Hs 78792 ESTs 37
435575 AF213457 Hs 44234 tnggenng receptor expressed on myeloid 37
409234 AI879419 Hs 27206 ESTs 37
420489 AA815089 Hs 193513 ESTs 37
426890 AA393167 Hs 41294 ESTs 37
438849 W28948 Hs 10762 ESTs 37
441869 NM 003947 Hs 8004 hundngtm-associated protein interacdn 37
448796 AA147829 Hs 301431 endothelial zinc finger protein induced 37
459318 NM 000038 gb Homo sapiens adenomatosis polyposis c 37
459518 AI937419 Hs 294069 Homo sapiens cDNA FLJ13384 fis clone PL 37
434444 AI765276 Hs 101257 hypothetical protein MGC3295 37
421183 AL135740 Hs 102447 TSC-22-lιke 37
410555 U92649 Hs 64311 a dismtegnn and metalloproteinase doma 37
421637 AF035290 Hs 106300 Homo sapiens clone 23556 mRNA sequence 37
418522 AA605038 Hs 7149 Homo sapiens cDNA FU21950 fis, clone H 37
420807 AA280627 Hs 57846 ESTs 37
449961 AW265634 Hs 133100 ESTs 37
422634 NM 016010 Hs 118821 CGI-62 protein 37
421030 AW161357 Hs 101174 microtubule-associated protein lau 37
427099 AB032953 Hs 173560 odd Ozften-m homolog 2 (Drosophila, mous 37
452355 N54926 Hs 29202 G protein-coupled receptor 34 37
440483 Al 200836 Hs 150386 ESTs 37
429597 NM 003816 Hs 2442 a dismtegnn and metalloproteinase doma 37
423756 AA828125 gb od71a09s1 NCI CGAP Ov2 Homo sapiens 36
425187 AW014486 Hs 22509 ESTs 36
434859 BE255080 Hs 299315 collapsin response mediator proteιn-5, C 36
413199 M62843 Hs 75236 ELAV (embryonic lethal, abnormal vision, 36
445729 H21066 Hs 13223 Homo sapiens mRNA full length insert cDN 36 416120 H46739 gb yo14h02 s1 Soares adult brain N2b5HB5 36
429239 AA448419 Hs 45209 ESTs 36
419086 NM 000216 Hs 89591 Kall ann syndrome 1 sequence 36
446659 AI335361 Hs 226376 ESTs 36
426757 AW205640 Hs 158206 ESTs 36
418819 AA228776 Hs 191721 ESTs 36
458332 AI000341 Hs 220491 ESTs 36
408826 AF216077 Hs 48376 Homo sapiens clone HB-2 mRNA sequence 36
410343 AA084273 Hs 76561 ESTs, Weakly similar to S47072 finger pr 36
410507 AA355288 Hs 40834 transidoπal epithelia response protein 36
422977 AA631498 gb πp83h04 s1 NCI_CGAP_Thy1 Homo sapiens 36
425305 AA363025 Hs 155572 Human done 23801 mRNA sequence 36
428002 AA418703 gb zv98c03 s1 Soares_NhHMPu_S1 Homo sapi 36
428505 AL035461 Hs 2281 chromogranin B (secretogranin 1) 36
430530 AA480870 Hs 47660 ESTs 36
436425 AI913146 Hs 318725 CGI-72 protein 36
438078 AI016377 Hs 131693 ESTs 36
442927 AI024347 Hs 131519 ESTs 36
446242 N66336 Hs 7360 ESTs 36
448831 AL080123 Hs 22182 zinc finger protein 23 (KOX 16) 36
450474 AW872844 Hs 201919 ESTs 36
452198 AI097560 Hs 61210 ESTs, Weakly similar to I38022 hypothed 36
455800 R22479 Hs 167073 Homo sapiens cDNA FU13047 fis, clone NT 36
436443 AW138211 Hs 128746 ESTs 36
426514 BE616633 Hs 170195 bone morphogenedc protein 7 (osteogenic 36
456038 AA203285 Hs 294141 ESTs, Weakly similar to altemadvely sp 36
408902 AW014869 Hs 5510 ESTs 36
442950 AI500417 Hs 46764 ESTs 36
423905 AW579960 Hs 135150 lung type-l cell membrane-associated gly 36
425478 AB007953 Hs 268840 ESTs 36
453884 AA355925 Hs 36232 KIAA0186 gene product 36
404721 36
408453 AI369838 Hs 5127 chondroidn sulfate proteoglycan 5 (neur 36
440553 AA889416 Hs 295362 Homo sapiens cDNA FU14459 fis, clone HE 35
446372 A8020644 Hs 14945 long fatty acyl-CoA synthetase 2 gene 35
413999 N46124 Hs 34460 ESTs 35
421458 NM 003654 Hs 104576 carbohydrate (keratan sulfate Gal-6) sul 35
425017 AL119305 Hs 288405 ESTs 35
435958 H98180 Hs 117975 ESTs 35
415101 R45531 Hs 144534 ESTs 35
451320 AW118072 Hs 89981 diacylglycerol kinase, zeta (104kD) 35
430290 AI734110 Hs 136355 ESTs 35
416836 D54745 Hs 80247 cholecystokinin 35
414821 M63835 Hs 77424 Fc fragment of IgG, high affinity la, re 35
419412 AW161058 Hs 90297 synuclein, beta 35
437860 AA333063 Hs 279898 Homo sapiens cDNA FLJ23165 fis ctone L 35
452689 F33868 Hs 284176 transfer™ 35
416661 AA634543 Hs 79440 IGF-II mRNA-bindmg protein 3 35
427491 R43279 Hs 22574 ESTs Weakly similar to I38022 hypotheti 35
428037 N47474 Hs 89230 potassium intermediate/small conductance 35
444584 AI168422 gb ok30e11 x1 Soares_NSF_F8_9W.OT_PA.P_S 35
408296 AL117452 Hs 44155 DKFZP586G1517 protein 35
453775 NM 002916 Hs 35120 replication factor C (activator 1) 4 (37 35
412659 AW753865 Hs 74376 olfactomedin related ER localized protei 35
429077 AB028983 Hs 2352 adenylate cyclase 2 (brain) 35
436887 AW953157 Hs 193235 hypothedcal protein DKFZp547D155 35
450784 AW246803 Hs 47289 ESTs 35
446827 AW451243 Hs 157069 ESTs 35
436434 N50465 Hs 92927 putative 47 kDa protein 35
412777 AI335773 Hs 270123 ESTs 35
436476 AA326108 Hs 33829 bHLH protein DEC2 35
408601 U47928 Hs 86122 protein A 34
429401 AW296102 Hs 99272 ESTs, Weakly similar to S32567 A4 protei 34
448425 AI500359 Hs 233401 ESTs 34
418727 AA227609 Hs 94834 ESTs 34
451729 AW160725 Hs 312469 ESTs 34
435910 AI084I52 Hs 21782 ESTs, Weakly similar to ALU7.HUMAN ALU S 34
434577 R37316 Hs 179769 Homo sapiens cDNA FU22487 fis. clone H 34
414598 AI094221 Hs 135150 lung type-l cell membrane-associated gly 34
439627 BE621702 Hs 29076 hypothedcal protein FU21841 34
413293 AL047483 Hs 302498 GTP-binding protein homologous to Saccha 34
423992 AW898292 Hs 137206 Homo sapiens mRNA, cDNA DKFZp564H1663 (f 34
426249 F05422 Hs 168352 nucleopoπn-like protein 1 34
426968 U07616 Hs 173034 amphiphysin (Sdff-Mann syndrome with br 34
430388 AA356923 Hs 240770 nuclear cap binding protein subunit 2, 2 34
435061 AI651474 Hs 163944 ESTs 34
452291 AF015592 Hs 28853 CDC7 (cell division cycle 7, S cerevisi 34
449714 AB033015 Hs 23941 KIAA1189 protein 34
443392 AI055821 Hs 293420 ESTs 34
410082 AA081594 Hs 158311 Musashi (Drosophila) homolog 1 34
445337 NM 013280 Hs 12523 fibronectin leucine πch transmembrane p 34
408493 BE206854 Hs 46039 phosphoglycerate mutase 2 (muscle) 34
432731 R31178 Hs 287820 fibronecdπ 1 34 448758 AB018311 Hs 21917 KIAA0768 protein 34
432613 AW081698 Hs 80712 KIAA0202 protein 34
434164 AW207019 Hs 148135 seπne/threonine kinase 33 34
425294 AF033827 Hs 155553 HNK-1 sulfotransferase 34
410108 AA081659 Hs 318775 OSBP-related protein 6 34
406815 AA833930 Hs 288036 tRNA isopentenylpyrophosphate transferas 34
402855 33
422170 AI791949 Hs 112432 and-MulIeπan hormone 33
445034 AW293376 Hs 143659 ESTs 33
424378 W28020 Hs 167988 neural cell adhesion molecule 1 33
423611 AB011163 Hs 129908 KIAA0591 protein 33
435593 R88872 Hs 4964 DKFZP586J1624 protein 33
404819 33
436607 AW661783 Hs 211061 ESTs 33
427315 AA179949 Hs 175563 Homo sapiens mRNA, cDNA DKFZp564N0763 (f 33
452693 T79153 Hs 48589 zinc finger protein 228 33
454996 AW850180 gb IL3-CT0219-271099-022-C09 CT0219 Homo 33
406927 M26460 gb Homo sapiens (ctone 104) rednoblasto 33
409045 AA635062 Hs 50094 Homo sapiens mRNA, cDNA DKFZp434O0515 (f 33
415238 R37780 Hs 21422 ESTs 33
417845 AL117461 Hs 82719 Homo sapiens mRNA, cDNA DKFZp586F1822 (f 33
421192 AA833718 Hs 204529 KIAA1806 protein 33
426695 AW118191 Hs 112729 ESTs 33
438885 AI886558 Hs 184987 ESTs 33
451762 AF222980 Hs 26985 disrupted in schizophrenia 1 33
452103 R42764 Hs 339654 ESTs, Weakly similar to 138022 hypothed 33
453590 AF150278 Hs 33578 KIAA0820 protein 33
453616 NM 003462 Hs 33846 dynein, axonemal, light intermediate pol 33
457285 AI038858 Hs 130522 Kv channel-interacting protein 1 33
436045 AB037723 Hs 5028 DKFZP564O0423 protein 33
437470 AL390147 Hs 134742 hypothedcal protein DKFZp547D065 33
448520 AB002367 Hs 21355 doublecordn and CaM kinase-like 1 33
436480 AJ271643 Hs 87469 putadve acid-sensing ion channel 33
432656 NM 000246 Hs 3076 MHC class II transacdvator 33
443898 AW804296 Hs 9950 Sec61 gamma 33
423582 BE000831 Hs 23837 Homo sapiens cDNA FLJ11812 fis clone HE 33
445953 AI612775 Hs 145710 ESTs 33
427940 AA417812 Hs 38775 ESTs 33
414683 S78296 Hs 76888 hypothedcal protein MGC12702 33
428484 AF104032 Hs 184601 solute earner family 7 (cationic ammo 33
420649 AI866964 Hs 124704 ESTs, Moderately similar to S65657 alpha 33
419498 AL036591 Hs 20887 hypothedcal protein FLJ10392 33
457579 AB030816 Hs 36761 HRAS-like suppressor 33
436556 AI364997 Hs 7572 ESTs 32
424369 R87622 Hs 26714 KIAA1831 protein 32
457065 AI476318 Hs 192480 ESTs 32
440210 AW674562 Hs 125296 ESTs 32
444513 AL120214 Hs 7117 glutamate receptor, lonotropic, AMPA 1 32
434353 AA630863 Hs 131375 ESTs, Moderately similar to ALUB.HUMAN ' 32
414430 AI346201 Hs 76118 ubiquitin carboxyl terminal esterase L1 32
439924 AI985897 Hs 125293 ESTs 32
411505 AF155659 Hs 70565 molybdenum cofactor synthesis 2 32
423175 W27595 Hs 18653 hypothetical protein FU 14627 32
415115 AA214228 Hs 127751 hypothedcal protein 32
407878 D87468 Hs 40888 acdvity-regulated cytoskeleton-associat 32
410274 AA381807 Hs 61762 hypoxia-mducible protein 2 32
437762 T78028 Hs 154679 synaptotagmin I 32
438944 AA302517 Hs 92732 KIAA1444 protein 32
450313 AI038989 Hs 332633 Bardet-Biedl syndrome 2 32
409459 D86407 Hs 54481 low density lipoprotein receptor-related 32
410953 AW811766 Hs 334858 hypothetical protein MGC12250 32
418527 AA450386 Hs 7149 Homo sapiens cDNA FU21950 fis, clone H 32
420081 AW510776 Hs 94958 tubulin tyrosine dgase-like 1 32
429496 AA453800 Hs 192793 ESTs 32
430099 AW194988 Hs 20537 hypothedcal protein FU13942 32
434928 AW015595 Hs 4267 Homo sapiens clones 24714 and 24715 mRNA 32
435532 AW291488 Hs 117305 Homo sapiens, clone IMAGE 3682908, mRNA 32
438306 AW188266 Hs 163645 ESTs 32
439274 AF086092 Hs 48372 ESTs 32
440847 AA907511 Hs 130178 ESTs 32
447750 AI422234 Hs 143434 contactin 1 32
455350 AW901809 gb QVO-NN1020-170400-195-I.02 NN1020 Homo 32
430890 X54232 Hs 2699 glypican 1 32
420568 F09247 Hs 247735 protocadheπn alpha 10 32
410768 AF038185 Hs 66187 Homo sapiens ctone 23700 mRNA sequence 32
427450 ' AB014526 Hs 178121 KIAA0626 gene product 32
430456 AA314998 Hs 241503 hypothedcal protein 32
430181 AF065314 Hs 234785 cyclic nucleotide gated channel alpha 3 32
418512 AW498974 Hs 89981 diacylglycerol kinase, zeta (104kD) 32
419912 AF249745 Hs 6066 Rho guanine nudeodde exchange factor ( 32
450689 AI369275 Hs 243010 Homo sapiens cDNA FU14445 fis, clone HE 32
424899 AL119387 Hs 119062 ESTs 32
436277 R88520 Hs 120917 ESTs 32 451455 AI937227 Hs 8821 hepcidm andmicrobial pepdde 32
445078 AI869975 Hs 4775 lunctophilin 3 32
447746 AW015920 Hs 161359 ESTs 32
435458 F11872 Hs 4892 Homo sapiens clone 24841 mRNA sequence 32
427729 AB033100 Hs 300646 KIAA protein (similar to mouse paladin) 32
417417 F05745 Hs 89512 ATPase, Ca->→ transporting, plasma membra 3 1
438810 AW897846 Hs 6421 hypothedcal protein DKFZp761N09121 31
439570 T79925 Hs 269165 ESTs, Weakly similar to ALU1 HUMAN ALU S 3 1
432527 AW975028 Hs 102754 ESTs 31
416801 X98834 Hs 79971 sal (Drosophιla)-lιke 2 3 1
421988 AW450481 Hs 161333 ESTs 3 1
426509 M31166 Hs 2050 pentaxin-related gene, rapidly induced b 31
408786 AA773187 Hs 294027 ESTs 3 1
433494 AB029396 Hs 3353 beta-1,3-glucuronyltransferase 1 (glucur 31
412723 AA648459 Hs 335951 hypothedcal protein AF301222 31
418329 AW247430 Hs 84152 cystathionine-beta-synthase 31
439456 AI752409 Hs 109314 hypothedcal protein FU20980 31
428832 AA578229 Hs 324239 ESTs, Moderately similar to ZN91.HUMAN Z 31
452780 BE171598 Hs 13522 ESTs, Weakly similar to I38022 hypothed 31
438192 AI859065 Hs 337620 Homo sapiens AFG3L1 isoform 1 mRNA, part 31
424939 AK000059 Hs 153881 Homo sapiens NY-REN-62 andgen mRNA, par 31
403053 R58624 Hs 2186 eukaryodc translation elongation factor 31
404299 3 1
407864 AF069291 Hs 40539 chromosome 8 open reading frame 1 31
410181 AI468210 Hs 261285 pleiotropic regulator 1 (PRL1, Arabidops 31
418852 BE537037 Hs 273294 hypothedcal protein FLJ20069 3 1
449101 AA205847 Hs 23016 G protein-coupled receptor 31
453240 AI969564 Hs 166254 hypothedcal protein DKFZp566M33 3 1
440486 BE243513 Hs 7212 hypothetical protein PP1044 31
408096 BE250162 Hs 83765 dihydrofolate reductase 31
439864 AI720078 Hs 291997 ESTs, Weakly similar to A47582 B-cell gr 3 1
414706 AW340125 Hs 76989 KIAA0097 gene product 3 1
436315 BE390513 Hs 27935 hypothedcal protem MGC4837 31
426855 AL117427 Hs 172778 Homo sapiens mRNA, cDNA DKFZp566P013 (fr 31
425683 AB037813 Hs 159200 hypothetical protein DKFZp762K222 3 1
410126 BE169274 Hs 169387 KIAA0036 gene product 31
435312 AJ243396 Hs 4865 voltage-gated sodium channel beta-3 subu 31
425491 AA883316 Hs 255221 ESTs 31
456273 AF154846 Hs 1148 zinc finger protein 31
412140 AA219691 Hs 73625 RAB6 interacting, kinesin-like (rabkines 3 1
445255 NM 014841 Hs 12477 synaptosomal-associated protein, 91 kDa 3 1
432154 AI701523 Hs 112577 ESTs 31
453128 AW026516 Hs 31791 acylphosphatase 2, muscle type 3 1
438458 AW975186 gb EST387294 MAGE resequences, MAGN Homo 3 1
448616 AF035621 Hs 21611 kinesin family member 3C 30
429281 AA830856 Hs 29808 Homo sapiens cDNA FU21122 fis, clone C 30
443906 AA348031 Hs 7913 ESTs 30
417318 AW953937 Hs 12891 ESTs 30
452619 AW298597 Hs 61884 Homo sapiens, clone IMAGE 4298026, mRNA, 30
444153 AK001610 Hs 10414 hypothetical protein FU10748 30
408790 AW580227 Hs 47860 neurotrophic tyrosine kinase, receptor, 30
426327 W03242 Hs 44898 Homo sapiens clone TCCCTA00151 mRNA sequ 30
451468 AW503398 Hs 293663 ESTs Moderately similar to I38022 hypot 30
422758 AF152329 Hs 284180 protocadheπn gamma subfamily C, 3 30
421633 AF121860 Hs 106260 sorting nexin 10 30
428361 NM 015905 Hs 183858 transcπpdonal intermediary factor 1 30
418932 L34059 Hs 89484 cadheπn 4, type 1 , R-cadhenn (rednal) 30
416805 F13271 Hs 79981 Human clone 23560 mRNA sequence 30
419518 U79289 Hs 90798 Human clone 23695 mRNA sequence 30
422709 AA315331 Hs 153485 ESTs 30
423135 N67655 Hs 26411 ESTs 30
424901 Z11933 Hs 182505 POU domain, class 3, transcnpdon facto 30
426617 W58006 Hs 266258 endonuclease G-like 1 30
427386 AW836261 Hs 337717 ESTs 30
429859 NM 007050 Hs 225952 protein tyrosine phosphatase, receptor t 30
435071 D60683 Hs 35495 ESTs 30
435092 AL137310 Hs 4749 Homo sapiens mRNA, cDNA DKFZp761E13121 ( 30
436211 AK001581 Hs 334828 hypothetical protein FLJ10719, KIAA1794 30
436936 AU 34451 Hs 197478 ESTs 30
445855 BE247129 Hs 145569 ESTs 30
452294 AI871925 Hs 117895 ESTs. Moderately similar to A47582 B-cel 30
433980 AA137152 Hs 286049 phosphosenne aminotransferase 30
430228 AW950939 Hs 6382 ESTs Highly similar to T00391 hypotheti 30
451026 AA013218 Hs 157492 cer-d4 (mouse) homolog 30
435232 NM.0O1262 Hs 4854 cyclm-dependent kinase inhibitor 2C (p1 30
439566 AF086387 gb Homo sapiens full length insert cDNA 30
425782 U66468 Hs 159525 cell growth regulatory with EF-hand doma 30
416586 D44643 Hs 14144 secreted modular calcium-binding protein 30
416874 H98752 Hs 42568 ESTs 30
410386 W26187 Hs 3327 Homo sapiens cDNA FU22219 fis, clone H 30
411411 AA345241 Hs 55950 ESTs Weakly similar to KIAA1330 protein 30
424066 Z99348 Hs 112461 ESTs, Weakly similar to I38022 hypothed 30
404048 30 429163 AA884766 gb am20a10 s1 Soares_NFL_T_GBC_S1 Homo s 30
454117 BE410100 Hs 40368 adaptor-related protein complex 1, Sigma 30
418196 AI745649 Hs 26549 KIAA1708 protein 30
434131 AI858275 Hs 143659 ESTs 30
441255 R06350 Hs 171635 ESTs 29
453900 AW003582 Hs 226414 ESTs, Weakly similar to ALU8.HUMAN ALU S 29
453905 NM 002314 Hs 36566 LIM domain kinase 1 29
416602 NM 006159 Hs 79389 nel (chιcken)-lιke 2 29
431173 AW971198 Hs 294068 ESTs 29
425599 AW366745 Hs 214140 ESTs, Weakly similar to ALU1 HUMAN ALU S 29
436401 AI087958 Hs 29088 ESTs 29
422960 AW890487 Hs 63984 cadheππ 13, H-cadhenn (heart) 29
451558 NM 001089 Hs 26630 ATP-bindmg cassette, sub-family A (ABC1 29
412490 AW803564 Hs 288850 Homo sapiens cDNA FU22528 fis, clone H 29
433149 BE257672 Hs 42949 hypothedcal protein HES6 29
434811 AW971205 Hs 114280 ESTs 29
425897 AA935315 Hs48965 Homo sapiens cDNA. FU21693 fis, clone C 29
452092 BE245374 Hs 27842 hypothedcal protein FU11210 29
453496 AA442103 Hs 33084 solute earner family 2 (facilitated glu 29
411124 AW196937 Hs 53929 ESTs, Weakly similar to ALUB.HUMAN «« 29
419227 BE537383 Hs 89739 cholmergic receptor, nicodnic. beta po 29
427651 AW405731 Hs 18498 Homo sapiens cDNA FU 12277 fis, done MA 29
441707 R42637 Hs 21963 hypothedcal protein DKFZp761B0514 29
435741 AI240668 Hs 113099 ESTs 29
437273 AL137451 Hs 120873 ESTs, Highly similar to T46266 hypothed 29
422939 AW394055 Hs 98427 ESTs, Weakly similar to I38022 hypothed 29
439376 AA883521 Hs 222064 ESTs 29
439935 S75105 Hs 301676 glutamate receptor, lonotropic, kainate 29
437267 AW511443 Hs 258110 ESTs 29
453740 AL120295 Hs 311809 ESTs, Moderately similar to PC4259 fem 29
400250 29
400992 29
408814 N62499 Hs 176227 hypothedcal protein FU11155 29
411849 AW964970 Hs 18861 ESTs, Moderately similar to KIAA1276 pro 29
414853 U31116 Hs 77501 sarcoglycan, beta (43kD dystrophin-assoc 29
423751 AW235633 Hs 46525 ESTs 29
426910 AA470023 Hs 190089 ESTs, Moderately similar to ALU1.HUMAN A 29
450203 AF097994 Hs 301528 L-kyπurenine/alpha-ammoadipate ammotra 29
459311 R40192 Hs 21527 Human DNA sequence from clone GS1-115M3 29
425304 AA463844 Hs 31339 fibroblast growth factor 11 29
428500 AI815395 Hs 184641 fatty acid desaturase 2 29
421641 AI638184 Hs 106334 Homo sapiens clone 23836 mRNA sequence 29
421141 AW117261 Hs 125914 ESTs 29
407870 AB032990 Hs40719 hypothedcal protein KIAA1164 29
456723 Z43902 Hs4748 adenylate cyclase acdvadng polypeptide 29
436456 AW292677 Hs 248122 G protein-coupled receptor 24 29
421483 NM 003388 Hs 104717 hypothedcal protein MGC11333 29
412190 R16180 Hs 274461 ESTs 29
446131 NM 000929 Hs290 phospholipase A2, group V 29
441668 AI611973 Hs 127525 ESTs 29
437387 AI198874 Hs 28847 AD026 protein 29
423420 AI571364 Hs 128382 Homo sapiens mRNA, cDNA DKFZp761l1224 (f 29
427958 AA418000 Hs 98280 potassium intermediate/small conductance 29
429084 AJ001443 Hs 195614 splicing factor 3b, subunit 3, 130kD 29
447067 R42098 Hs 21964 ESTs 29
430887 N66801 Hs 260287 KIAA1841 protein 29
441824 AB007871 Hs7977 KIAA0411 gene product 29
424126 AA335635 Hs 96917 ESTs 29
408739 W01556 Hs 238797 ESTs, Moderately similar to I38022 hypot 29
447422 BE618703 Hs 98258 orthopedia (Drosphila) homolog 29
435615 Y15065 Hs 4975 potassium voltage-gated channel, KQT-lik 29
446997 AA383439 Hs 16758 Spιr-1 protein 29
433573 AF234887 Hs 57652 cadhenn, EGF LAG seven-pass G-type rece 29
408447 AK002089 Hs45080 Homo sapiens cDNA FU11227 fis, clone PL 29
419586 AI088485 Hs 144759 ESTs, Weakly similar to I38022 hypothed 28
417022 NM 014737 Hs 80905 Ras association (RalGDS/AF-6) domain fam 28
408432 AW^95262 gb n67b05 x1 NCI.CGAP.CML1 Homo sapiens 28
420320 AB002361 Hs 96633 KIAA0363 protein 28
425241 AA324624 Hs 155247 aldolase C, fructose-bisphosphate 28
428670 AA431682 Hs 134832 ESTs 28
424415 NM.001975 Hs 146580 enolase 2, (gamma, neuronal) 28
409185 AW961601 Hs 252406 hypothedcal protein FU 12296 similar to 28
411555 AF113537 Hs 70669 HMP19 protein 28
426847 S78723 Hs 298623 5-hydroxytryptamme (serotonin) receptor 28
458809 AW972512 Hs 20985 sιn3-assocιated polypeptide, 30kD 28
420071 AB028985 Hs 94806 ATP-bindmg cassette, sub-family A (ABC1 28
424572 M19650 Hs 150741 2,3-cyclιc nudeodde 3 phosphodieste 28
444670 H58373 Hs 332938 hypothedcal protein MGC5370 28
411089 AA456454 Hs 183418 cell division cycle 2-lιke 1 (PITSLRE pr 28
416111 AA033813 Hs 79018 chromatin assembly factor 1 , subunit A ( 28
440637 AW900115 Hs 7309 Homo sapiens clone 23741 mRNA sequence 28
408554 AA836381 Hs 315111 nuclear receptor cc-repressor/HDAC3 comp 28
403056 R58624 Hs 2186 eukarγodc transladon elongation factor 28 423449 AI497900 Hs 33067 ESTs 28
424188 AW954552 Hs 142634 zinc finger protein 28
429006 AA443143 Hs 50929 hypothetical protein FU13842 28
434981 AW182577 Hs 293077 ESTs 28
437435 AA249439 Hs 27027 hypothetical protein DKFZp762H1311 28
442748 AI016713 Hs 135787 ESTs 28
443312 N52025 Hs 46616 ESTs 28
450940 AI744943 Hs 143209 ESTs, Weakly similar to I38022 hypothed 28
452738 AL133800 Hs 7086 hypothedcal protein MGC12435 28
409182 AA064970 Hs 118145 ESTs 28
439793 AA018825 Hs 7934 Kruppel-like factor 4 (gut) 28
432683 AW995441 Hs 10475 ESTs 28
434269 AK001991 HS 3781 similar to muπne leucine-nch repeat pr 28
429500 X78565 Hs 289114 hexabrachion (tenascin C cytotacdn) 28
433290 R20077 Hs 302185 Homo sapiens clone 23618 mRNA sequence 28
434276 AF123659 Hs 93605 teucine zipper, putative tumor suppresso 28
435977 AL138079 Hs 5012 bram-specific membrane-anchored protein 28
430294 AI538226 Hs 32976 guanine nucleotide binding protein 4 28
425168 R96366 gb yq37d04 s1 Soares fetal liver spleen 28
428180 AI129767 Hs 182874 guanine nudeodde binding protein (G pr 28
409348 AI401535 Hs 146090 ESTs 28
409887 AL137534 Hs 56876 Homo sapiens mRNA, cDNA DKFZp434H1419 (f 28
457211 AW972565 Hs 32399 ESTs, Weakly similar to S51797 vasodilat 28
430039 BE253012 Hs 153400 ESTs, Weakly similar to ALUI.HUMAN ALU S 28
417642 BE302665 Hs 105461 hypothedcal protein FU 20357 28
419169 AW851980 Hs 262346 ESTs, Weakly similar to S72482 hypotheti 28
434008 AA740878 Hs 112982 ESTs 28
446776 AW293417 Hs 156455 ESTs 28
408838 AI669535 Hs 40369 ESTs 28
422565 BE259035 Hs 118400 singed (Drosophila) like (sea urchin fas 28
447397 BE247676 Hs 18442 E-1 enzyme 28
412530 AA766268 Hs 266273 hypothedcal protein FU13346 28
424330 AW073953 Hs 333396 Homo sapiens cDNA FU13596 fis, clone PL 28
446377 AW014022 Hs 170953 ESTs 28
458924 BE242158 Hs 24427 DKFZP56601646 protein 28
447710 AI420523 Hs 328241 ESTs 28
404049 28
416913 AW934714 gb C1-DT0001-031299-011-a11 DT0001 Homo 28
426400 M78361 Hs 169743 Homo sapiens clone 25121 neuronal olfact 28
413264 W26456 Hs 134757 hypothetical protein FU20033 28
458997 AW937420 Hs 69662 ESTs 27
422864 AA318323 gb EST20390 Retina II Homo sapiens cDNA 27
430526 AF181862 Hs 242407 G protein-coupled receptor, family C, gr 27
452023 AB032999 Hs 27566 KIAA1173 protein 27
432022 AL162042 Hs 272348 Homo sapiens mRNA, cDNA DKFZp761L1212 (f 27
452438 BE514230 Hs 29595 JM4 protein 27
435408 H07897 Hs 4302 ESTs, Weakly similar to T29299 hypothed 27
418791 AA935633 Hs 194628 ESTs 27
438821 AA826425 Hs 291829 ESTs 27
423464 NM 016240 Hs 128856 CSR1 protein 27
442091 AW770493 Hs 182874 guanine nudeodde binding protein (G pr 27
442242 AV647908 Hs 90424 Homo sapiens cDNA FU23285 fis, clone H 27
412436 AA665089 gb nu76d01 s1 NCI_CGAP_Alv1 Homo sapiens 27
432821 BE170702 Hs 279005 solute earner family 21 (organic anion 27
416404 AA180138 Hs 107924 ESTs 27
441364 AW450466 Hs 126830 ESTs, Weakly similar to YD38.YEAST HYPOT 27
450202 AW969756 Hs 34145 ESTs, Weakly similar to B49647 GTP-bindi 27
426304 AA374532 Hs 124673 Homo sapιens cDNA FU11477 fis, clone HE 27
428722 U76456 Hs 190787 dssue inhibitor of metalloproteinase 4 27
449701 AW952323 Hs 129908 KIAA0591 protein 27
420372 AW960049 Hs 293660 Homo sapiens, clone IMAGE 3535476 mRNA, 27
410318 AA084050 Hs 269259 ESTs, Weakly similar to S23650 retroviru 27
414603 R58394 Hs 25119 ESTs, Weakly similar to YEX0.YEAST HYPOT 27
416096 H18577 Hs 88974 cytochrome b-245, beta polypeptide (chro 27
420896 AW149342 Hs 24444 Homo sapiens cDNA FLJ22165 fis, clone H 27
424856 AA347746 Hs 9521 ESTs, Weakly similar to ZN43 HUMAN ZINC 27
436304 AA339622 Hs 108887 ESTs 27
441027 AI911412 Hs 126444 ESTs 27
452545 N31940 Hs 14434 ESTs, Weakly similar to I38022 hypothed 27
454201 AB023191 Hs 44131 KIAA0974 protein 27
448560 BE613183 Hs 23213 ESTs 27
426807 AA385315 Hs 156682 ESTs 27
425825 AI929508 Hs 159590 lymphocyte andgen 6 complex, locus H 27
440351 AF030933 Hs 7179 RAD1 (S pombe) homolog 27
425390 AI092634 Hs 156114 protein tyrosine phosphatase, non-recept 27
427624 AA406245 Hs 24895 ESTs 27
426413 AA377823 gb EST90805 Synovial sarcoma Homo sapien 27
422491 AA338548 Hs 117546 neuronatin 27
424560 AA158727 Hs 150555 protein predicted by clone 23733 27
432415 T16971 Hs 289014 ESTs, Weakly similar to A43932 mucin 2 p 27
414865 AA157155 Hs 274414 hypothetical protein FLJ14457 27
415827 H17462 Hs 23079 ESTs 27
445568 H00918 Hs 268744 KIAA1796 protein 27 433315 R96754 Hs 239706 GRB2-assocιated binding protein 1 27
428862 NM 000346 Hs 2316 SRY (sex determining region Y)-box 9 (ca 27
447959 AI452784 Hs 270270 ESTs, Weakly similar to 2109260A B cell 27
426420 BE383808 Hs 322430 NDRG family, member 4 27
436899 AA764852 Hs 291567 ESTs 27
444100 AA383343 Hs 22116 COC14 (cell division cycle 14, S cerevi 27
426501 AW043782 Hs 293616 ESTs 27
449092 U91641 Hs 22985 alphaZ.β-sialyltransferase 27
427311 AB020672 Hs 175411 KIAA0865 protein 27
453313 BE005771 Hs 153746 hypothedcal protein FU22490 27
404029 27
416289 W26333 Hs 337438 ESTs 27
439108 AW163034 Hs 6467 synaptogyπn 3 26
418746 AI955289 Hs 300759 πbosomal protein L36 26
412046 Y07847 Hs 73088 RAS-related on chromsome 22 26
435040 AI932350 Hs 152825 ESTs 26
453083 U87223 Hs 31622 contactin associated protein 1 26
428167 AA770021 Hs 16332 ESTs 26
420028 AB014680 Hs 8786 carbohydrate (N-acetylglucosamιne-6-O) s 26
443715 AI583187 Hs 9700 cyclin E1 26
421247 BE391727 Hs 102910 general transcnpdon fador HH, polype 26
424687 J05070 Hs 151738 matπx metalloproteinase 9 (geladnase B 26
415056 AB004662 Hs 77867 adenosine A1 receptor 26
451697 AW449774 Hs 296380 POM (POM121 rat homolog) and ZP3 fusion 26
433701 AW445023 Hs 15155 ESTs 26
457358 AI479755 Hs 129010 ESTs 26
430347 NM 002039 Hs 239706 GRB2-assocιated binding protein 1 26
418027 AB037807 Hs 83293 hypothedcal protein 26
440491 R35252 Hs 24944 ESTs, Weakly similar to 2109260A B cell 26
425171 AW732240 Hs 16365 ESTs 26
459335 AW298545 Hs 250726 EST 26
425402 AI215881 Hs 24970 ESTs, Weakly similar to B34323 GTP-bindi 26
453169 AB037815 Hs 32156 KIAA1394 protein 26
433647 AA603367 Hs 222294 ESTs 26
450414 AI907735 Hs 21446 KIAA1716 protein 26
446233 AI282028 Hs 25205 ESTs 26
415446 F08898 Hs 66075 ESTs 26
445873 AA250970 Hs 251946 poly(A)-bmdmg protein, cytoplasmic 1-1 26
413012 D83777 Hs 75137 KIAA0193 gene product 26
428671 BE297851 Hs 189482 zinc finger protein 179 26
427158 AA935603 Hs 166231 ESTs 26
408988 AL119844 Hs 49476 Homo sapiens clone TUA8 Cπ-du-chat regi 26
459516 AI049662 Hs 246858 EST 26
402693 26
408039 AA131424 Hs 50340 ESTs 26
422896 AW961489 Hs 154116 ESTs 26
423130 AW897586 Hs 21213 ESTs 26
438796 W67821 Hs 109590 genethon 1 26
439871 R88518 Hs 46736 hypothedcal protein FU23476 26
440192 AA872282 Hs 190596 ESTs 26
419708 AK000753 Hs 92374 hypothetical protein 26
449436 AA860329 Hs 279307 hypothetical protein DKFZp434l2117 26
436870 AW204219 Hs 155560 calnexin 26
448424 AW009892 Hs 31924 ESTs 26
401324 26
414136 AA812434 Hs 119023 SMC2 (structural maintenance of chromoso 26
433943 AA992805 Hs 44865 lymphoid enhancer-binding factor 1 26
428001 H97428 Hs 219907 ESTs, Moderately similar to Transforming 26
429139 F09092 Hs 66087 ESTs 26
423073 BE252922 Hs 123119 MAD (mothers against decapentaplegic, Dr 26
448966 AW372914 Hs 86149 phosphoinositol 3-phosphate-bιndιng prot 26
444001 AI095087 Hs 152299 ESTs, Moderately similar to S65657 alpha 26
412049 N53437 Hs 18268 adenylate kinase 5 26
441783 BE313412 Hs 7961 Homo sapiens clone 25012 mRNA sequence 26
425287 R88249 Hs 155524 peanut (Drosophιla)-lιke 2 26
432149 AW614326 Hs 157022 ESTs, Weakly similar to T34549 probable 26
452234 AW084176 Hs 223296 ESTs, Weakly similar to I38022 hypothed 26
453478 AF083898 Hs 33021 neuro-oncological ventral andgen 2 26
418962 AA714835 Hs 271863 ESTs 26
418858 AW961605 Hs 21145 hypothedcal protein RG083M052 26
443257 AI334040 Hs 11614 HSPC065 protein 26
428748 AW593206 Hs 98785 Ksp37 protein 26
444984 H15474 Hs 132898 fatty acid desaturase 1 26
433404 T32982 Hs 102720 ESTs 26
434779 AF153815 Hs 50151 potassium inwardly-rectifying channel, s 26
420582 BE047878 Hs 99093 Homo sapiens chromosome 19, cosmid R2837 26
452856 AF034799 Hs 30881 protein tyrosine phosphatase, receptor t 26
436440 AI471862 Hs 196008 Homo sapiens cDNA FU 11723 fis, clone HE 26
438527 AI969251 Hs 115325 RAB7, member RAS oncogene family-like 1 26
433216 AF217412 Hs 47320 neuroligin 3 26
435380 AA679001 Hs 192221 ESTs 26
428966 AF05921 Hs 194687 cholesterol 25-hydroxylase 26
439653 AW021103 Hs 6631 hypothedcal protein FU 20373 26 419304 AI271326 Hs 146101 ESTs, Weakly similar to T45070 protein k 26
422991 H10940 Hs 48965 Homo sapiens cDNA FU21693 fis, clone C 26
448548 R13209 Hs 21413 solute earner family 12, (potassium-chl 26
435370 AI964074 Hs 225838 ESTs 26
408875 NM 015434 Hs 48604 DKFZP434B168 protein 25
457005 AJ007421 Hs 172597 sal (Drosophιla)-lιke 3 25
430154 AW583058 Hs 234726 senne (or cysteine) proteinase iπhibito 25
438549 BE386801 Hs 21858 tππucleodde repeat containing 3 25
427951 AI826125 Hs 43546 ESTs 25
411800 N39342 Hs 103042 microtubule-associated protein 1B 25
457683 AI821877 Hs 140002 ESTs, Moderately similar to ALU7.HUMAN A 25
451422 AB002336 Hs 26395 erythrocyte membrane protein band 41-lι 25
430713 AA351647 Hs 2642 eukaryodc transladon elongadon factor 25
428826 AL048842 Hs 194019 attractin 25
428963 AW382682 Hs 258208 Homo sapiens, clone MGC 15606, mRNA com 25
428141 D50402 Hs 182611 solute earner family 11 (proton-coupled 25
429550 AW293055 Hs 119357 ESTs 25
438662 AA223599 Hs 6351 cleavage and polyadenylation specific fa 25
435760 AF231922 Hs 213004 chromosome 21 open reading frame 62 25
427513 AI476318 Hs 192480 ESTs 25
430061 AB037817 Hs 230188 KIAA1396 protein 25
435923 BE301930 Hs 5010 Homo sapiens clone 24672 mRNA sequence 25
417123 BE326521 Hs 159450 ESTs 25
439699 AF086534 Hs 187561 ESTs, Moderately similar to ALU1.HUMAN A 25
412980 AI815750 Hs 20977 hypothedcal protein MGC3129 similar to 25
427209 H06509 Hs 92423 KIAA1566 prote 25
424327 AA431707 Hs 31209 ESTs 25
436340 R42246 Hs 21606 ESTs 25
450650 T65617 Hs 101257 hypothedcal protein MGC3295 25
439444 AI277652 Hs 54578 ESTs, Weakly similar to 138022 hypothed 25
400777 25
439478 AF049460 Hs 6574 deformed epidermal autoregulatory factor 25
450407 NM 000810 Hs 24969 gamma-aminobutync acid (GABA) A recepto 25
450385 AI631024 Hs 24948 synuclein, alpha interacdπg protein (sy 25
432558 R97268 Hs 177269 ESTs 25
400860 25
410361 BE391804 Hs 62661 guanylate binding protein 1, interferon- 25
416063 BE047699 Hs 93454 ESTs 25
414998 NM 002543 Hs 77729 oxidised low density lipoprotein (lectn 25
452823 AB012124 Hs 30696 transcnpdon factor like 5 (basic helix 25
417791 AW965339 Hs 111471 ESTs 25
418079 R40058 Hs 6911 ESTs 25
408495 W68796 Hs 237731 ESTs 25
442104 L20971 Hs 188 phosphodiesterase 4B, cAMP-specilic (dun 25
437370 AL359567 Hs 161962 Homo sapiens mRNA, cDNA DKFZp547D023 (fr 25
429803 W81489 Hs 223025 RAB31 , member RAS oncogene family 25
424959 NM 005781 Hs 153937 acdvated p21cdc42Hs kinase 25
427413 BE547647 Hs 177781 hypothetical protein MGC5618 25
408955 BE315170 Hs 8087 NAG-5 protein 25
415261 T40928 Hs 8346 ESTs 25
415716 N59294 Hs 179662 nucleosome assembly protein 1 like 1 25
417873 BE266659 Hs 293659 Homo sapiens, Similar to RIKEN cDNA A430 25
418388 R72332 Hs 29258 Homo sapiens cDNA FLJ 11364 fis, clone HE 25
421002 AF116030 Hs 100932 transcnpdon factor 17 25
423244 AL039379 Hs 209602 ESTs, Weakly similar to ubiquitous TPR m 25
423553 AA405635 Hs 96854 ESTs, Weakly similar to DYLX HUMAN CYTOP 25
427961 AW293165 Hs 143134 ESTs 25
428301 AW628666 Hs 98440 ESTs, Weakly similar to 138022 hypothed 25
428508 BE252383 Hs 184668 SBBI31 protein 25
428858 AA436760 gb zv67d11 r1 Soares_t0tal_fetus_Nb2HF8_ 25
428943 AW086180 Hs 37636 ESTs, Weakly similar to KIAA1392 protein 25
432427 AL037630 Hs 6638 Homo sapiens cDNA FU 11602 fis clone HE 25
435347 AW014873 Hs 116963 ESTs 25
437949 U78519 Hs 41654 ESTs, Weakly similar to A46010 X-lmked 25
438208 AL041224 Hs 65379 ESTs 25
440286 U29589 Hs 7138 cholinergic receptor, muscaπnic 3 25
441523 AW514263 Hs 301771 ESTs, Weakly similar to ALUF.HUMAN mi 25
441805 AA285136 Hs 301914 neuronal specific transcnpdon factor D 25
442337 AI371029 Hs 129257 ESTs, Weakly similar to TC17 HUMAN TRANS 25
442789 AW904361 Hs 131191 ESTs, Weakly similar to ALU7.HUMAN ALU S 25
445556 AI910241 Hs 12887 acdn-related protein 3-beta 25
449086 AI628357 Hs 208037 ESTs 25
459583 AI907673 gb IL-BT 152-080399-004 BT152 Homo sapien 25
TABLE 24B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Numbei ' Accession
408432 1058667 1 AW195262 R27868 AW811262
412225 1284108 AW902042 N77591
412436 129439.1 AA665089 AA135130 AA484059 AA102419 AW877765 416120 1571266 1 H46739 H51513 H19779
416871 1626761 1 H98716N90792 N24283
416913 163001 T AW934714 BE161007 BE162500 AW749902 AW749864 BE162498 BE161005 AA190449 AW513465 BE161006 BE162499
422864 222336 1 AA318323 H11145 R15289AA451945AA476690AA436954 Z43802F11753T65491 D81821
422949 223184 1 AA319435 N56456 AA319377 AW961532 T48452 AA894424
422977 223410J AA631498 AI017191 AA491211 AA761823 AA714555 AA768099 AA808286 AI934069 AA570223 AA574389 AA582438 AI745346 AW964510 AA319642
AW853758 H56414
423756 231725 1 AA828125 AA834883 AA330555
425168 247552 1 R96366 AL133929 AA351636 H78818 AA477084 Z28957 H80194
425517 252729 1 AF121179 BE162736AA358827
426413 266650 1 AA377823 AW954494 AI022688
428002 285602 1 AA418703AA418711 BE071915 BE071920BE071912
428679 294049 1 AA431765AA432015
428858 296453 1 AA436760 AW237453 BE327496 N47347 N56967
429007 298301 1 080642 AA443145 AL119015 AW904500
429163 300543 1 AA884766 AW974271 AA592975 AA447312
433532 368950 1 AW975367 AA598607 AA742735
436190 41555 1 AK001059AA633055
437034 431713 1 AA742643 AA808575 AW976668
438458 457837 1 AW975186 AA807807 D29548
438993 467651 1 AA828995 AA834879 AI926361
439566 47387 1 AF086387W77884W72711
440322 491966 1 AA879430 BE070262 BE070493 BE070272 BE070484 BE070397 BE070395 BE070201 BE070198 BE070404 BE070270 BE070400
444584 611496 1 Al 168422 D80113 T59074
447197 711623 1 R36075AI366546 R36167
448451 764066 1 AW015994 R39898AW000978AI598202AI521706
450625 84032 1 AW970107 AA513951 AA010406
452453 918300 1 AI902519 AI902518 A1902516
454996 1248640 1 AW850180 AW850326
455350 1283853 1 AW901809 AW901787 AW901795 AW901792 AW901744 AW901753 AW901807 AW901798
TABLE 24C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publication endtled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted Nt_posιdon Indicates nucleotide posidons of predicted exons
Pkey Ref Strand Nt position
400777 8131663 Plus 70745-71121
400780 8131663 Minus 118372-118619
400859 9757499 Minus 91888-92018,98131-98294,99474-99570
400860 9757499 Minus 151830-152104,152649-152744
400992 8096828 Plus 140390-140822
401324 9863791 Plus 234057-234174
402408 9796239 Minus 110326-110491
402604 9909420 Plus 20393-20767
402605 9909420 Minus 47680-47973
402693 8569863 Minus 82366-82515
402855 9662953 Minus 59763-59909
404029 7671252 Plus 108716-111112
404048 3688074 Minus 54421-56808
404049 3688074 Minus 75765-78155
404283 2276311 Minus 99460-99564
404299 5738652 Minus 3826-4025
404541 8318559 Pius 103456-103664
404584 9857511 Plus 138651-139153
404593 9944086 Minus 74922-75788
404721 9856648 Minus 173763-174294
404819 4678240 Plus 16223-16319,16427-16513,16736-16859,16941-17075,17170-17287,17389-17529,18261-18357,18443-18578
405238 7249119 Minus 51728-51836
405771 7018349 Plus 91191-91254,91510-91589
405819 4007557 Plus 2830-2967
406311 9211559 Minus 137114-139033
TABLE 25A ABOUT 1202 GENES UP-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CENTRAL NERVOUS SYSTEM (CNS)
Table 25A lists about 1202 genes up-regulated in glioblastoma compared to normal adult central nervous system (CNS) These were selected from 59680 probesets on the
Affymetnx/Eos Hu03 GeneChip array such that the rado of "average* glioblastoma to 'average* normal adult CNS tissues was greater than or equal to 20 The "average" glioblastoma level was set to the 75* percendle amongst various glioblastoma tumors The "average" normal adult CNS dssue level wβs set to the 95* percendle amongst vanous non-malignant dssues In order to remove gene-specific background levels of non-specific hybπdizadon the lO" percendle value amongst vaπous non-malignant dssues was subtracted from both the numerator and the denominator before the rado was evaluated
Pkey Unique Eos probeset identifier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Tide Unigene gene title
R1 Ratio of 75* percendle tumor to 95* percendle normal adult nervous system dssue
Pkey ExAccn UnigenelD Unigene Title R1 452461 N78223 Hs 108106 transcnpdon factor 20 1
436895 AF037335 Hs 5338 carbonic anhydrase XII 152
453941 U39817 Hs 36820 Bloom syndrome 142
443247 BE614387 Hs 333893 c-Myc target JP01 124 428330 L22524 Hs 2256 matπx metalloproteinase 7 (matπlysin, 120
447342 AI199268 Hs 19322 Homo sapiens, Similar to RIKEN cDNA 2010 11 7
422163 AF027208 Hs 112360 prominin (mouse)-lιke 1 11 4
439451 AF086270 Hs 278554 heterochromadn-like protein 1 11 2
424800 AL035588 Hs 153203 MyoD family inhibitor 10 2
416111 AA033813 Hs 79018 chromadn assembly factor 1 , subunit A ( 100
444190 AI878918 Hs 10526 cysteine and glycine-nch protein 2 99
412140 AA219691 Hs 73625 FtAB6 interacdng, kinesin-dke (rabkmes 99
449340 AW235786 Hs 195359 hypothedcal protein MGC10954 98
409731 AA125985 Hs 56145 thymosm, beta, idendfied in neuroblast 94
439978 BE139460 Hs 124673 Homo sapiens cDNA FU11477 fis, clone HE 89
411411 AA345241 Hs 55950 ESTs, Weakly similar to KIAA1330 protein 89
456516 BE172704 Hs 222746 KIAA1610 protein 82
420092 AA814043 Hs 88045 ESTs 79
422631 BE218919 Hs 118793 hypothedcal protein FU 10688 79
453392 U23752 Hs 32964 SRY (sex determining region Y)-box 11 79
438527 AI969251 Hs 115325 RAB7, member RAS oncogene family-like 1 79
427581 NM 014788 Hs 179703 KIAA0129 gene product 78
418661 NM 001949 Hs 1189 E2F transcnpdon factor 3 78
440684 AI253123 Hs 127356 ESTs, Highly similar to S21424 nesdn [H 78
429643 AA455889 Hs 167279 FYVE-finger-contaiπing Rab5 effector pro 77
409638 AW450420 Hs 21335 ESTs 75
444665 BE613126 Hs 47783 B aggressive lymphoma gene 75
456759 BE259150 Hs 127792 delta (Drosophιla)-lιke 3 75
412777 AI335773 Hs 270123 ESTs 74
436607 AW661783 Hs 211061 ESTs 73
432058 AW665996 Hs 130729 ESTs, Weakly similar to ALU1JHUMAN ALU S 73
417061 AI675944 Hs 188691 Homo sapiens cDNA FLJ12033 fis, clone HE 73
428976 AL037824 Hs 194695 ras homolog gene family, member I 72
433244 AB040943 Hs 271285 KIAA1510 protein 7 1
436726 AA324975 Hs 128993 ESTs. Weakly similar to T00079 hypothed 71
408432 AW195262 gb xn67b05 x1 NCI_CGAP_CML1 Homo sapiens 7 1
434164 AW207019 Hs 148135 seπne/threomne kinase 33 70
445873 AA250970 Hs 251946 poly(A)-bιndιng protein, cytoplasmic 1-1 70
439726 AW449893 Hs 293707 ESTs, Weakly similar to 138598 zinc fing 70
432656 NM 000246 Hs 3076 MHC class II transacdvator 68
431117 AF003522 Hs 250500 delta (Drosophιla)-lιke 1 68
453387 AI990741 Hs 252809 ESTs 68
418821 AA436002 Hs 183161 ESTs 66
437034 AA742643 gb ny91c01 s1 NCI_CGAP_GCB1 Homo sapiens 66
411252 AB018549 Hs 69328 MD-2 protein 65
424687 J05070 Hs 151738 matπx metalloproteinase 9 (geladnase B 64
452953 AI932884 Hs 271741 ESTs, Weakly similar to A46010 X-linked 63
433532 AW975367 gb EST387475 MAGE resequences, MAGN Homo 63
420311 AW445044 Hs 38207 Human DNA sequence from clone RP4-530I15 63
418097 R45137 Hs 21868 ESTs 62
407304 AA565832 gb πj32b03 s1 NCI_CGAP_AA1 Homo sapiens 62
435256 AF193766 Hs 13872 cytokiπe-like protein C17 6 1
449448 D60730 Hs 57471 ESTs 6 1
403790 60
425517 AF121179 gb AF 121179 Homo sapiens liver (Chang L- 60
420674 NM 000055 Hs 1327 butyiylcholinesterase 60
435542 AA687376 Hs 269533 ESTs 59
418216 AA662240 Hs 283099 AF15q14 protem 58
439086 AF085947 gb Homo sapiens full length insert cDNA 58
408037 AW271720 Hs 42233 hypothedcal protein FU10300 57
412225 AW902042 gb QV0-NN1022-170400-193-C02 NN1022 Homo 57
436109 AA922153 Hs 132760 hypothedcal protein MGC15729 57
435005 U80743 Hs 306094 tπnucleodde repeat containing 12 57
429149 AW193360 Hs 197962 ESTs, Weakly similar to I38022 hypothed 57
418113 AI272141 Hs 83484 SRY (sex determining region Y)-box 4 56
405558 56
442432 BE093589 Hs 38178 hypothedcal protein FU23468 56
442547 AA306997 Hs 217484 ESTs, Weakly similar to ALU1_HUMAN ALU S 56
413063 AL035737 Hs 75184 chidnase 3-lιke 1 (cartilage glycoprote 55
420560 AW207748 Hs 59115 ESTs 55
408096 BE250162 Hs 83765 dihydrofolate reductase 55
443539 AI076182 Hs 134074 ESTs, Moderately similar to ALU6.HUMAN A 54
426318 AA375125 Hs 147112 Homo sapiens cDNA FU22322 fis, clone H 54
429115 AA446728 Hs 289020 Homo sapiens cDNA FU 14098 fis clone MA 53
453900 AW003582 Hs 226414 ESTs, Weakly similar to ALU8 HUMAN ALU S 53
444168 AW379879 gb RC1-HT0256-081199-011-f01 HT0256 Homo 53
432789 D26361 Hs 3104 KIAA0042 gene product 53
437036 AI571514 Hs 133022 ESTs 52
421247 BE391727 Hs 102910 general transcnpdon factor MH. polype 52
441523 AW514263 Hs 301771 ESTs, Weakly similar to ALUF_HUMAN "" 52
451106 BE382701 Hs 25960 v-myc avian myelocytomatosis viral relat 5 1
457211 AW972565 Hs 32399 ESTs, Weakly similar to S51797 vasodilat 5 1
454157 AW162906 Hs 312481 ESTs, Weakly similar to S66668 hydrogen 51
423343 AA324643 Hs 246106 ESTs 5 1
425292 NM 005824 Hs 155545 37 kDaleucme-πch repeat (LRR) protein 5 1
406679 AA070786 gb zm66b07 r1 Stratagene neuroepithelium 5 1
442671 AI005668 Hs 134779 EST 5 1 433001 AF217513 Hs 279905 clone HQ0310 PRO0310p1 50
418819 AA228776 Hs 191721 ESTs 50
432946 U60899 Hs 279854 mannosidase, alpha, class 28, member 1 49
420730 NM 002691 Hs 99890 polymerase (DNA directed), delta 1, cata 49
441217 AI922183 Hs 213246 ESTs 49
453385 AW296101 Hs 252806 ESTs 48
418203 X54942 Hs 83758 CDC28 protein kinase 2 47
450813 AI739625 Hs 203376 ESTs 47
444006 BE395085 Hs 10086 type I transmembrane protein Fn14 47
412530 AA766268 Hs 266273 hypothedcal protein FU13346 47
431070 AW408164 Hs 249184 transcnpdon factor 19 (SC1) 47
429786 AL080232 Hs 220696 Homo sapiens mRNA, cDNA DKFZp586A061 (fr 47
405771 46
457065 AI476318 Hs 192480 ESTs 46
436190 AK001059 gb Homo sapiens cDNA FU10197 fis, clone 46
400859 46
435267 N23797 Hs 110114 ESTs 46
443454 AI057494 Hs 133421 ESTs 45
452811 AA937079 Hs 118983 hypothedcal protein FU12150 45
437267 AW511443 Hs 258110 ESTs 45
435020 AW505076 Hs 301855 DiGeorge syndrome cπdcal region gene 8 45
454269 AI961060 Hs 129908 KIAA0591 protein 45
422106 D84239 Hs 111732 Fc fragment of IgG binding protein 45
422765 AW409701 Hs 1578 baculoviral IAP repeat-containing 5 (sur 45
456534 X91195 Hs 100623 phospholipase C, beta 3, neighbor pseudo 45
423756 AA828125 gb od71 a09 s 1 NCI_CGAP_Ov2 Homo sapiens 45
417308 H60720 Hs 81892 KIAA0101 gene product 45
422170 AI791949 Hs 112432 and-Mullenan hormone 44
429500 X78565 Hs 289114 hexabrachion (tenascin C, cytotacdn) 44
406568 AF088886 Hs 11590 cathepsin F 44
426812 AF105365 Hs 172613 solute earner family 12 (potassium chlo 44
402516 44
432865 AI753709 Hs 152484 ESTs, Weakly similar to I38022 hypotheti 44
413625 AW451103 Hs 71371 ESTs 44
436098 R20597 Hs 9739 glycerol-3-phosphate dehydrogenase 1 (so 44
418333 W92113 gb zh48e01 r1 Soares_fetal_lιver_spleen_ 44
416933 BE561850 Hs 80506 small nuclear nbonucleoprotein polypept 44
438192 AI859065 Hs 337620 Homo sapiens AFG3L1 isoform 1 mRNA, part 43
457374 AA493662 gb nh05d12 s1 NCI_CGAP.Thy1 Homo sapiens 43
433159 AB035898 Hs 150587 kinesin-like protein 2 43
444386 BE065183 gb RC1-BT0314-020200-012-C04 BT0314 Homo 43
453202 AW085781 Hs 26270 hypothedcal protem FU11588 43
441020 W79283 Hs 35962 ESTs 43
414733 BE514535 Hs 77171 minichromosome maintenance deficient (S 43
407902 AL117474 Hs 41181 Homo sapiens mRNA, cDNA DKFZp727C191 (fr 43
405701 43
451659 BE379761 Hs 14248 ESTs 43
418845 AA852985 Hs 89232 chromobox homolog 5 (Drosophila HP1 alph 42
433323 AA805132 Hs 30701 ESTs 42
439811 AA135332 Hs 71608 ESTs 42
415406 T26510 gb AB282F8R Infant brain, LLNL array of 42
436282 R91913 Hs 272104 ESTs, Moderately similar to ALU1.HUMAN A 41
441269 AW015206 Hs 178784 ESTs 41
418727 AA227609 Hs 94834 ESTs 41
433006 BE242758 Hs 190223 ESTs, Moderately similar to T29285 hypot 41
436480 AJ271643 Hs87469 putadve acid-sensing ion channel 41
430786 AA486144 Hs 31293 ESTs 41
445372 N36417 Hs 144928 ESTs 41
410555 U92649 Hs 64311 3 dismtegnn and metalloproteinase doma 40
457465 AW301344 Hs 122908 DNA replicadon factor 40
422094 AF129535 Hs 272027 F-box only protein 5 40
442029 AW956698 Hs 14456 neural precursor cell expressed, develop 40
459321 AW044477 Hs 299538 ESTs 40
421308 AA687322 Hs 192843 leucine zipper protem FKSG14 40
420567 AK000812 Hs 98874 similar to prolme-πch protein 48 40
447004 AW296968 Hs 157539 ESTs 40
448295 AI381911 Hs 334859 KIAA1814 protein 39
439699 AF086534 Hs 187561 ESTs, Moderately similar to ALU1.HUMAN A 39
440704 M69241 Hs162 insulin-like growth factor binding prote 39
453096 AW294631 Hs 11325 ESTs 39
457026 AA397620 Hs 48692 ESTs 39
404642 39
450375 AA009647 Hs 8850 a dismtegnn and metalloproteinase doma 39
430132 AA204686 Hs 234149 hypothedcal protein FU20647 39
437718 AI927288 Hs 196779 ESTs 39
438490 AW593272 Hs 301299 ESTs 39
429919 AA460692 Hs 278945 hypothedcal protein FU 23024 39
413604 R51767 gb yg73g11 r1 Soares infant brain 1NIB H 39
425599 AW366745 Hs 214140 ESTs, Weakly similar to ALU1 HUMAN ALU S 39
448796 AA147829 Hs 301431 endothelial zinc finger protein induced 39
449300 AI656959 Hs 222165 ESTs 38
452203 X57522 Hs 158164 transporter 1, ATP-bindmg cassette, sub 38
425769 U72513 Hs 159486 Human RPL13-2 pseudogene mRNA, complete 38 404295 38
410361 BE391804 Hs 62661 guanylate binding protein 1, interferon- 38
428728 NM 016625 Hs 191381 hypothedcal protein 38
409142 AL136877 Hs 50758 SMC4 (structural maintenance of chromoso 38
430172 AA468591 Hs 161889 ESTs 38
447499 AW262580 Hs 147674 protocadhenn beta 16 38
405884 38
437236 AW137817 Hs 244353 ESTs 37
418883 BE387036 Hs 1211 acid phosphatase 5, tartrate resistant 37
444143 AW747996 Hs 160999 ESTs, Moderately similar to A56194 throm 37
425529 NM 014656 Hs 158282 KIAA0040 gene product 37
425502 R98895 Hs 125823 ESTs 37
419741 NM_007019 Hs 93002 ubiquitin earner protein E2-C 37
402424 37
429469 M64590 Hs 27 glycine dehydrogenase (decarboxyladng, 37
434072 H70854 Hs 283059 Homo sapiens PRO1082 mRNA, complete eds 37
414872 U82010 Hs 77513 COX10 (yeast) homolog, cytochrome c oxid 37
426071 AW138057 Hs 163835 ESTs 37
419078 M93119 Hs 89584 insulinoma-associated 1 37
428037 N47474 Hs 89230 potassium intermediate/small conductance 37
416547 H62914 Hs 268946 ESTs, Weakly similar to PC4259 femdn 37
436899 AA764852 Hs 291567 ESTs 36
436722 AW975977 gb EST388086 MAGE resequences, MAGN Homo 36
440652 AI216751 Hs 143977 ESTs 36
428450 NM 014791 Hs 184339 KIAA0175 gene product 36
452103 R42764 Hs 339654 ESTs, Weakly similar to 138022 hypothed 36
409048 H59990 Hs 37699 ESTs 36
439546 AF088056 gb Homo sapiens full length insert cDNA 36
443544 AI076315 Hs 16359 ESTs 36
418478 U38945 Hs 1174 cyclin-dependent kinase inhibitor 2A (me 36
435889 AI249107 Hs 269901 ESTs 36
420301 AA767526 Hs 22030 paired box gene 5 (B-cell lineage specif 36
438078 AI016377 Hs 131693 ESTs 36
408420 NM 006915 Hs 44766 retinitis pigmentosa 2 (X-linked recessi 36
416871 H98716 gb yx13d08 s1 Soares melanocyte 2NbHM Ho 35
424085 NM 002914 Hs 139226 replicadon factor C (acdvator 1) 2 (40 35
446291 BE397753 Hs 14623 interferon gamma-induαble protein 30 35
432281 AK0O1239 Hs 274263 hypothedcal protein FU10377 35
436123 AA057484 Hs 35406 ESTs, Highly similar to unnamed protein 35
411256 AW834039 gb QV0-TT0010-091199-053-e09 TT0010 Homo 35
419239 AA468183 Hs 184598 Homo sapiens cDNA FU23241 fis, clone C 35
435065 BE064391 gb RC4-BT0310-110300-015-b08 BT0310 Homo 35
435532 AW291488 Hs 117305 Homo sapiens, clone IMAGE 3682908, mRNA 35
447101 N72185 Hs 44189 ESTs 35
410530 M25809 Hs 64173 ATPase, H+ transporting, lysosomal (vacu 35
422156 N34524 gb yy56d10 s1 Soares.muldple.sclerosis. 35
453616 NM 003462 Hs 33846 dynein, axonemal, light intermediate pol 35
439743 AL389956 Hs 283858 Homo sapiens mRNA full length insert cDN 35
453884 AA355925 Hs 36232 KIAA0186 gene product 35
424954 NM_O00546 Hs 1846 tumor protein p53 (Li-Fraumeni syndrome) 35
420721 AA927802 Hs 159471 ZAP3 protein 35
426764 AA732524 Hs 151464 ESTs, Weakly similar to ALUC.HUMAN «« 34
420649 AI866964 Hs 124704 ESTs, Moderately similar to S65657 alpha 34
448831 AL080123 Hs 22182 zinc finger protein 23 (KOX 16) 34
444371 BE540274 Hs 239 forkhead box M1 34
402604 34
442407 AW469584 Hs 32353 mitogen-acdvated protein kinase kinase 34
414300 AI304870 Hs 188680 ESTs 34
444670 H58373 Hs 332938 hypothedcal protein MGC5370 34
414550 BE379808 gb 601159567T1 IH MGC 53 Homo sapiens c 34
452211 AI985513 Hs 233420 ESTs 34
414416 AW409985 Hs 76084 hypothedcal protein MGC2721 34
449961 AW265634 Hs 133100 ESTs 34
413257 BE075035 gb PM3-BT0584-260300-002-g05 BT0584 Homo 34
453857 AL080235 Hs 35861 DKFZP586E1621 protein 34
417404 NM.007350 Hs 82101 pleckstnn homology-like domain, family 34
422846 BE513934 Hs 1583 neutrophil cytosolic factor 1 (47kD, chr 34
446189 H85224 Hs 214013 ESTs 34
437385 AA757055 Hs 164060 ESTs 34
453652 AW009640 Hs 28368 ESTs Moderately similar to S65657 alpha 34
408298 AI745325 Hs 271923 Homo sapiens cDNA FU22785 fis, clone K 34
455778 BE088746 gb CM2-BT0693-210300-123-J09 BT0693 Homo 33
417546 H65569 Hs 18845 ESTs 33
412471 M63193 Hs 73946 endothelial cell growth factor 1 (platel 33
454631 AW811324 gb IL3-ST0141-131099-017-A02 ST0141 Homo 33
454294 AB000734 Hs 50640 JAK binding protein 33
457131 ACO02310 Hs 301463 Human Chromosome 16 BAC clone CIT987SK-A 33
410102 AW248508 Hs 279727 Homo sapiens cDNA FLJ14035 fis, clone HE 33
449676 AW380579 Hs 209657 ESTs 33
436211 AK001581 Hs 334828 hypothetical protein FU10719, KIAA1794 33
453746 AL120611 gb DKFZp761H119.r1 761 (synonym hamy2) 33
452799 AI948829 Hs 213786 ESTs 33
435380 AA679001 Hs 192221 ESTs 33 426746 J03626 Hs 2057 uπdme monophosphate synthetase (orolat 33
453362 H1 988 Hs 107375 ESTs 33
456473 AI202788 Hs 25682 Homo sapiens mRNA for KIAA1863 protem, 33
416426 AA180256 Hs 210473 Homo sapiens cDNA FLJ14872 fis, clone PL 33
445777 AI580371 Hs 145384 ESTs 33
423757 AL049337 Hs 132571 Homo sapiens mRNA, cDNA DKFZp564P016 (fr 33
431941 AK000106 Hs 272227 Homo sapiens cDNA FU20099 fis, clone CO 33
404299 33
404108 33
425189 H16622 gb ym26c07 r1 Soares infant brain 1NIB H 33
449318 AW236021 Hs 78531 Homo sapiens. Similar to RIKEN cDNA 5730 33
450193 AI916071 Hs 15607 Homo sapiens Faπconi anemia complemeπtat 32
427725 U66839 Hs 180533 mitogen-acdvated protein kinase kinase 32
424051 AL110203 Hs 138411 Homo sapiens mRNA, cDNA DKFZp586J1922 (f 32
418968 NM 000078 Hs 89538 cholesteiyl ester transfer protein, plas 32
449248 M33782 Hs 23391 Homo sapiens, Similar to transcnpdon f 32
439416 W58294 Hs 56254 ESTs 32
401596 AA172106 Hs 110950 Rag C protein 32
408380 AF123050 Hs 44532 diubiquitin 32
450325 AI935962 Hs 26289 ESTs 32
428730 AA625947 Hs 25750 ESTs 32
457536 AA305233 Hs 278712 eukaiyodc translation midadon fader 32
426836 N41720 Hs 172684 vesicle-associated membrane protein 8 (e 32
442710 AI015631 Hs 23210 ESTs 32
435232 NM 001262 Hs 4854 cycl -dependent kinase inhibitor 2C (p1 32
430970 AI018210 Hs 144083 ESTs 32
416192 NM 005036 Hs 998 peroxisome proliferative activated recep 32
446676 H09380 Hs 300965 ESTs 32
451459 AI797515 Hs 270560 ESTs, Moderately similar to ALU7.HUMAN A 32
407603 AW955705 Hs 62604 Homo sapiens, clone IMAGE 4299322, mRNA, 32
413840 AI301558 Hs 146381 RNA binding modf protein, X chromosome 32
448751 BE551203 Hs 201792 ESTs 32
432593 AW301003 Hs 51483 ESTs, Weakly similar to hypothedcal pro 32
458786 AI457098 Hs 280848 ESTs 32
455909 BE156417 Hs 278798 ESTs 32
419311 AA689591 gb nv66a12 s1 NCI_CGAP_GCB1 Homo sapiens 32
439710 AF086543 gb Homo sapiens full length insert cDNA 32
434559 AF147315 gb Homo sapiens full length insert cDNA 3 1
455800 R22479 Hs 167073 Homo sapiens cDNA FU 13047 fis, clone NT 31
436703 AW880614 Hs 146381 RNA binding odf protein, X chromosome 3 1
414799 AI752416 Hs 77326 insulin-like growth factor binding prote 31
437860 AA333063 Hs 279898 Homo sapiens cDNA FU23165 fis, clone L 3 1
434182 W20309 Hs 118520 G-protem gamma-12 subunit 3 1
417900 BE250127 Hs 82906 CDC20 (cell division cycle 20, S cerevi 3 1
434769 AA648884 Hs 134278 Homo sapiens cDNA FU12676 fis, clone NT 31
414825 X06370 Hs 77432 epidermal growth factor receptor (avian 3 1
426413 AA377823 gb EST90805 Synovial sarcoma Homo sapien 3 1
447959 AI452784 Hs 270270 ESTs, Weakly similar to 2109260A B cell 3 1
404589 3 1
421764 AI681535 Hs 148135 seπne/threonme kinase 33 3 1
419986 AI345455 Hs 78915 GA-bindmg protein transcnpdon factor, 3 1
416941 BE000150 Hs 48778 niban protein 3 1
414761 AU077228 Hs 77256 enhancer of zeste (Drosophila) homolog 2 3 1
449611 AI970394 Hs 197075 ESTs 31
434746 AA648368 Hs 295368 ESTs 3 1
434274 AA628539 Hs 116252 ESTs, Moderately similar to ALU1_HUMAN A 31
427899 AA829286 Hs 332053 serum amyloid A1 3 1
417642 BE302665 Hs 105461 hypothedcal protein FU20357 31
452472 AW957300 Hs 294142 ESTs, Weakly similar to C55663 oligodeπd 31
446131 NM 000929 Hs 290 phospholipase A2, group V 31
440052 AI633744 Hs 195648 ESTs. Weakly similar to I38022 hypotheti 3 1
426531 AA381071 gb EST94100 Acbvated T-cells XII Homo s 3 1
422158 L10343 Hs 112341 protease inhibitor 3, skm-denved (SKAL 3 1
406267 3 1
447039 AV661798 Hs 282915 ESTs 3 1
404802 3 1
406927 M26460 gb Homo sapiens (clone 104) rednoblasto 31
419314 AW971924 Hs 87280 ESTs 30
435894 AI076667 Hs 188011 ESTs 30
432140 AK000404 Hs 272688 hypothedcal protein FU20397 30
443426 AF098158 Hs 9329 chromosome 20 open reading frame 1 30
425202 AW962282 Hs 152049 ESTs, Weakly similar to I38022 hypotheti 30
407047 X65965 gb H sapiens SOD-2 gene for manganese su 30
418241 M26682 Hs 1149 LIM domain only 1 (rhombodn 1) 30
446599 Z97832 Hs 15476 differentially expressed in FDCP (mouse 30
412950 BE018581 Hs 245342 hypothetical protein FU 14642 30
428670 AA431682 Hs 134832 ESTs 30
446975 BE246446 Hs 16695 ubiquidn-acdvadng enzyme E1 -like 30
437756 AA767537 Hs 197096 ESTs 30
416084 L16991 Hs 79006 deoxythy idylate kinase (thymidylate kin 30
402374 AL135225 Hs 301865 dopachrome tautomerase (dopachrome delta 30
443885 H91806 Hs 15284 ESTs 30
434008 AA740878 Hs 112982 ESTs 30 452568 AA805634 Hs 300870 Homo sapiens mRNA. cDNA DKFZp547M072 (fr 30
414239 AI288330 Hs 182330 ESTs 30
421013 M62397 Hs 1345 mutated in colorectal cancers 30
424635 AA420687 Hs 115455 Homo sapiens cDNA FU14259 fis, clone PL 30
410276 AI554545 Hs 68301 ESTs 30
433865 N29862 Hs 44104 ESTs 30
406028 30
401626 30
415949 H10562 Hs 21691 ESTs 30
418583 AA604379 Hs 86211 hypothedcal protein 30
417933 X02308 Hs 82962 thymidylate synthetase 30
434577 R37316 Hs 179769 Homo sapiens cDNA FU22487 fis, done H 30
430437 AI768801 Hs 169943 Homo sapiens cDNA FLJ 13569 fis, clone PL 30
427940 AA417812 Hs 38775 ESTs 29
456060 C14904 Hs 45184 Homo sapiens cDNA FU12284 (is, clone MA 29
421988 AW450481 Hs 161333 ESTs 29
448775 AB025237 Hs 388 nudix (nucleoside diphosphate linked oi 29
438598 AI805943 Hs 326067 hypothedcal protein MGC5178 29
429612 AF062649 Hs 252587 pituitary tumor-transforming 1 29
451189 AA016019 Hs 40905 ESTs 29
401558 29
426207 BE390657 Hs 30026 HSPC182 protein 29
404721 29
401384 29
417288 AI984792 Hs 108812 hypothedcal protein FU22004 29
427648 AI376722 Hs 180062 proteasome (prosome, macropain) subunit. 29
435928 H64345 Hs 183961 ESTs 29
431740 N75450 Hs 183412 ESTs, Moderately similar to AF116721 67 29
428242 H55709 Hs 2250 leukemia inhibitory factor (cholinergic 29
439972 AI348100 Hs 124662 ESTs 29
433112 AA973801 Hs 144553 ESTs, Weakly similar to unnamed protein 29
423751 AW235633 Hs 46525 ESTs 29
406748 AW339106 Hs 217493 annexin A2 29
422154 T79045 Hs 126927 ESTs 29
405588 29
440911 AA909536 Hs 143562 ESTs 29
412420 AL035668 Hs 73853 bone morphogenedc protein 2 29
445043 AW014413 Hs 196066 ESTs 29
410114 AW590540 Hs 271280 ESTs 29
419217 AA504571 gb aa60e12 r1 NCI CGAP.GCB1 Homo sapiens 29
415849 R20529 Hs 6806 ESTs 29
448140 AF146761 Hs 20450 BCM-like membrane protein precursor 29
453331 AI240665 Hs 8895 ESTs 29
432065 AA401039 Hs 2903 protein phosphatase 4 (formerly X), cata 29
438380 T06430 Hs 6194 chondroidn sulfate proteoglycan BEHAB/b 29
454377 AA076811 gb 7B03C12 Chromosome 7 Fetal Brain cDNA 29
421491 H99999 Hs 42736 ESTs 29
452291 AF015592 Hs 28853 CDC7 (cell division cycle 7, S cerevisi 28
415446 F08898 Hs 66075 ESTs 28
439518 W76326 gb zd60d04 r1 Soares_fetal_heart_NbHH19W 28
427221 L15409 Hs 174007 von Hippel-Lindau syndrome 28
422493 AW474183 Hs 250173 hypothedcal protein FLJ13158 28
419451 AI907117 Hs 90535 syntaxin binding protein 2 28
448789 BE539108 Hs 22051 hypothetical protein MGC15548 28
424126 AA335635 Hs 96917 ESTs 28
458695 AV660159 Hs 282284 ESTs, Weakly similar to I38022 hypothed 28
418973 AA233056 Hs 191518 ESTs 28
440471 AA886146 Hs 307944 ESTs 28
421016 AA504583 Hs 101047 transcnpdon factor 3 (E2A immunoglobul 28
433647 AA603367 Hs 222294 ESTs 28
415817 U88967 Hs 78867 protein tyrosine phosphatase, receptor-t 28
421723 AA620400 Hs 300717 sodium channel, voltage-gated, type III, 28
434964 AI638850 Hs 130746 ESTs 28
432022 AL162042 Hs 272348 Homo sapiens mRNA cDNA DKFZp761 L1212 (f 28
400517 AF242388 Hs 149585 lengsm 28
433023 AW864793 Hs 87409 thrombospondin 1 28
448734 BE614070 Hs 326416 Homo sapiens mRNA, cDNA DKFZp564H1916 (f 28
406736 AI254733 Hs 182426 nbosomal protein S2 28
409207 AW373564 Hs 194637 BANP homolog SMAR1 homolog 28
440196 N72847 Hs 125221 ESTs 28
403961 28
425193 AW965689 Hs 22509 ESTs 28
425268 AI807883 Hs 180059 Homo sapiens cDNA FU20653 (is, clone KA 28
440483 AI200836 Hs 150386 ESTs 28
412391 AW947710 gb RCO-MT0004-130300-011-e07 MT0004 Homo 28
448769 N66037 Hs 38173 ESTs 28
411632 AW854829 gb QV2-CT0261-201099-011-f01 CT0261 Homo 28
438221 AI798853 Hs 122224 ESTs, Weakly similar to ALU5 HUMAN ALU S 28
457578 AA578027 gb nl20h01 s1 NCI_CGAP_HSC1 Homo sapiens 28
455510 AA422029 Hs 143640 ESTs, Weakly similar to hyperpolanzado 28
447769 AW873704 Hs 320831 Homo sapiens cDNA FU14597 fis, clone NT 28
427701 AA411101 Hs 243886 nuclear autoantigeπic sperm protein (his 28
433800 AI034361 Hs 135150 lung type-l cell membrane-associated gly 28 439662 H97552 Hs 269060 ESTs 28
425694 U51333 Hs 159237 hexokmase 3 (white cell) 28
414747 U30872 Hs 77204 centromere protein F (350/400kD, mitosiπ 28
414598 AI094221 Hs 135150 lung type-l cell membrane-associated gly 28
447752 M73700 Hs 105938 lactotraπsfemn 28
408761 AA057264 Hs 238936 ESTs, Weakly similar to (defline not ava 28
453350 AI917771 Hs 61790 hypothedcal protein FU 23338 27
456629 AW891965 Hs 279789 histone deacetylase 3 27
439538 AA837323 Hs 164047 ESTs 27
458814 AI498957 Hs 170861 ESTs, Weakly similar to Z195.HUMAN ZINC 27
456029 BE255990 Hs 218329 hypothetical protein 27
451129 BE072881 gb RC2-8T0548-200300-0!2-e09 BT0548 Homo 27
456412 AW749617 Hs 280776 tankyrase, TRF1-ιnteracdng ankyπn-rela 27
453536 AA137000 Hs 62578 ESTs 27
438378 AW970529 Hs 86434 hypothedcal protein FU21816 27
425745 U44060 Hs 14427 Homo sapiens cDNA FU2180O (is, clone H 27
446322 N23033 Hs 155814 ESTs 27
451592 AI805416 Hs 213897 ESTs 27
429466 M85835 Hs 12827 ESTs 27
429747 M87507 Hs 2490 caspase 1, apoptosis-related cysteine pr 27
455514 AW983871 gb RC1-HN0003-220300-021-h07 HN0003 Homo 27
414732 AW410976 Hs 77152 minichromosome maintenance deficient (S 27
444207 AI565004 Hs 79572 cathepsin D (lysosomal aspartyl protease 27
427421 AA402414 Hs 3059 coatomer protein complex, subunit beta 27
449655 AI021987 Hs 59970 ESTs 27
422648 086983 Hs 118893 Melanoma associated gene 27
428494 AA233439 Hs 184634 hypothedcal protein FU20005 27
406895 X60648 Hs 172550 polypyπmidine tract binding protein (he 27
453255 AA278167 Hs 19215 Homo sapiens, clone IMAGE 3605822, mRNA 27
427348 NM 014137 Hs 177258 PRO0650 protein 27
435370 AI964074 Hs 225838 ESTs 27
407862 BE548267 Hs 50724 Homo sapiens cDNA FU10934 fis, clone OV 27
411874 AA096106 Hs 20403 ESTs 27
421192 AA833718 Hs 204529 KIAA1806 protein 27
435899 W89093 Hs 189914 ESTs 27
414603 R58394 Hs 25119 ESTs, Weakly similar to YEX0 YEAST HYPOT 27
453462 AL037291 Hs 236605 ESTs, Moderately similar to ALU4 HUMAN A 27
436554 AI985810 Hs 301173 ESTs 27
427528 AU077143 Hs 179565 minichromosome maintenance deficient (S 27
403881 27
431779 AW971178 Hs 268571 apolipoprotein C-l 27
404984 27
448275 BE514434 Hs 20830 kmesin-like 2 27
446839 BE091926 Hs 16244 mitotic spindle coiled-coil related prot 27
411927 BE274009 Hs 772 glycogen synthase 1 (muscle) 27
404756 27
447072 D61594 Hs 17279 tyrosylprotem sulfotransferase 1 27
422176 H80977 gb yu89a11 s1 Soares fetal liver spleen 27
439627 BE621702 Hs 29076 hypothetical protein FU21841 27
436532 AA721522 gb nv54h12 r1 NCI_CGAP_Ew1 Homo sapiens 27
412833 AW960547 Hs 298262 πbosomal protem S 19 27
457245 AI745498 Hs 204579 ESTs 27
446861 AI696519 Hs 14427 Homo sapiens cDNA FLJ21800 fis, clone H 27
453263 R91778 Hs 99369 ESTs 27
459385 BE380047 gb 601159362F2 NIH MGC 53 Homo sapiens c 27
438764 AA824524 Hs 336452 ESTs 27
429285 AI971081 Hs 20432 ESTs, Weakly similar to I38022 hypothed 27
424853 BE549737 Hs 132967 Human EST clone 122887 manner transposo 27
430037 BE409649 Hs 227789 itogen-acdvated protein kinase-acdvat 27
449892 N73608 Hs 50309 ESTs 27
454201 AB023191 Hs 44131 KIAA0974 protein 27
452279 AA286844 Hs 61260 hypothetical protein FU13164 27
427954 J03060 Hs 247551 metaxin 1 27
400371 U80740 27
452449 AW068658 Hs 20943 ESTs 27
431114 AA492400 Hs 291015 ESTs 27
417088 M54915 Hs 81170 pιm-1 oncogene 27
447674 8E270640 Hs 19192 cyclm-dependent kinase 2 27
403680 27
454679 AW813110 gb CM4-ST0189-051099-021-.05 ST0189 Homo 27
411968 AI207410 Hs 69280 Homo sapiens, clone IMAGE 3636299, mRNA, 26
422240 R60594 Hs 29002 KIAA1706 protein 26
424368 AB037766 Hs 146085 KIAA1345 protein 26
405808 26
419700 AF084935 Hs 92357 galactokinase 1 26
435972 W95088 Hs 114198 ESTs 26
453568 S70782 Hs 557 adrenergic, alpha-1 D-, receptor 26
443725 AW245680 Hs 9701 growth aπest and DNA-damage-inducible, 26
444156 AW500059 Hs 86437 ESTs, Highly similar to AF219140 1 gastr 26
428209 AA424197 Hs 98947 ESTs Weakly similar to S33496 tiypsin [ 26
437640 AA764893 Hs 272155 ESTs, Weakly similar to I38022 hypothed 26
453948 AI970797 Hs 64859 ESTs 26
415402 AA164687 Hs 177576 mannosyl (alpha-1,3-)-glycoproteιn beta- 26 425397 J04088 Hs 156346 topoisomerase (DNA) II alpha (170kD) 26
418228 AA962181 Hs 111219 ESTs, Moderately similar to ALU1.HUMAN A 26
26
425234 AW152225 Hs 165909 ESTs, Weakly similar to I38022 hypothed 26
443210 AI692649 Hs9451 hypothetical protein MGC13168 26
457244 AA581385 Hs 162473 ESTs, Weakly similar to 138022 hypothed 26
417144 AA382104 Hs81337 lecdn galactoside-bindmg, soluble, 9 26
433933 AI754389 Hs 133494 Homo sapiens clone TCCCIA00164 mRNA sequ 26
437437 AA226869 Hs 16520 hypothedcal protein DKFZp762L0311 26
434206 AW136973 Hs 288516 ESTs, Weakly similar to S69890 mitogen i 26
400992 26
455530 AW984744 gb RC1-HN0015-040400-011-d03 HN0015 Homo 26
436139 AA765786 Hs 120936 ESTs 26
448330 AL036449 Hs 207163 ESTs 26
412942 AL120344 Hs 75074 mitogen-acdvated protein kinase-acdvat 26
432753 NM 014075 Hs 336938 Homo sapiens PRO0593 mRNA, complete eds 26
433430 AI863735 Hs 186755 ESTs 26
436693 AW973223 Hs 303197 B-cell CLL/lymphoma 7C 26
429482 AF076974 Hs 203952 fransformation/transcπpdon domam-asso 26
432715 AA247152 Hs 200483 ESTs, Weakly similar to KIAA1074 protein 26
414217 AI309298 Hs 279898 Homo sapiens cDNA FU23165 fis, done L 26
434165 AA971328 Hs 95361 myosin VIIA (Usher syndrome 1B (autosoma 26
414835 AA156720 Hs 185342 ESTs 26
424489 T48851 Hs 149250 D-siglec precursor, 26
436496 AA281959 Hs5210 glia maturadon factor, gamma 26
403797 26
434573 AW372340 Hs 159717 ESTs 26
418841 NM 002332 Hs 89137 low density lipoprotein-related protein 26
415785 R82419 Hs 23603 ESTs, Moderately similar to ALU8_HUMAN A 26
450608 AA010365 Hs 193229 ESTs 26
425304 AA463844 Hs 31339 fibroblast growth factor 11 26
432268 BE311856 Hs 274230 3'-phosphoadenosιne 5'-phosphosulfate sy 26
410507 AA355288 Hs 40834 traπsidonal epithelia response protein 26
427343 AI880044 Hs 176977 protein kinase C binding protein 2 26
420917 AW135716 Hs 117330 ESTs 26
414399 L47345 Hs 155202 transcπption elongation factor β (Sill) 26
446089 AI860021 Hs 270651 ESTs, Moderately similar to A47582 B-cel 26
440829 AF136407 Hs7446 chromosome 6 open reading frame 5 26
408475 AA315514 Hs 47986 hypothedcal protein MGC10940 26
450946 AA374569 Hs 127698 ESTs, Moderately similar to 2109260A B c 26
421462 AF016495 Hs 104624 aquapoπn 9 26
434846 AW295389 Hs 119768 ESTs 26
422887 AI751848 Hs49215 ESTs 26
417435 NM 005181 Hs 82129 carbonic aπhydrase III, muscle specific 26
437389 AL359587 Hs 271586 hypothedcal protein OKFZp762M115 25
408981 AW500797 Hs 49427 Gem-interacdπg protein 25
432180 Y18418 Hs 272822 RuvB (E coli homolog)-lιke 1 25
418079 R40058 Hs6911 ESTs 25
437820 AA769062 Hs 323836 ESTs, Weakly similar to alternatively sp 25
439685 AW956781 Hs 293937 ESTs Weakly similar to FXD2_HUMAN FORKH 25
425681 AB018297 Hs 159183 KIAA0754 protein 25
435177 AI018174 Hs 42936 ESTs 25
437323 AA371145 Hs 226627 leptiπ receptor 25
422114 AW194851 Hs 111801 arsenate resistance protein ARS2 25
448478 AI523218 Hs 203456 ESTs 25
426623 AA382826 Hs 132793 ESTs 25
448764 AI568607 Hs 182112 ESTs 25
458385 AI051489 Hs 246214 ESTs 25
403726 N28939 Hs 13434 Homo sapiens ctone 24418 mRNA sequence 25
444888 AI651039 Hs 148559 ESTs 25
456179 H75490 Hs 271930 ESTs 25
424840 D79987 Hs 153479 extra spindle poles, S cerevisiae, homo 25
406273 NM 000919 Hs 83920 pepddylglycme alpha-amidadng monooxyg 25
418054 NM 002318 Hs 83354 lysyl oxidase-hke 2 25
445936 BE543594 Hs 61478 hypothedcal protein FU 22329 25
454967 AW848276 gb IL3-CT0214-150200-074-E06 CT0214 Homo 25
442303 AA989289 Hs 129169 ESTs 25
456583 AF179897 Hs 104105 Meis (mouse) homolog 2 25
434263 N34895 Hs 44648 ESTs 25
416892 L24498 Hs 80409 growth aπest and DNA-da age-inducible, 25
424528 AW073971 Hs 238954 ESTs, Weakly similar to KIAA1204 protein 25
406038 Y14443 Hs 88219 zinc finger protein 200 25
413495 Y12395 Hs 315177 interferon-related developmental regulat 25
423098 AA321980 Hs 204682 ESTs 25
410817 AI262789 Hs 93659 protein disulfide isomerase related prot 25
439841 AF038961 Hs6710 mannose-P-dolichol udtizadon defect 1 25
453828 AW970960 Hs 293821 ESTs 25
445034 AW293376 Hs 143659 ESTs 25
449620 BE407797 Hs 23794 checkpoint with forkhead and nng finger 25
406876 AI382286 Hs 180842 nbosomal protein L13 25
412370 AW946614 gb RC2-ET0021-280400-011-C05 ET0021 Homo 25
423642 AW452650 Hs 157148 hypothedcal protein MGC13204 25
430357 AW976789 Hs 165607 ESTs 25 414853 U31116 Hs 77501 sarcoglycan, beta (43kD dystroph -assoc 25
416097 BE387371 Hs 118964 hypothedcal protein FLJ20085 25
428619 AK002140 Hs 187378 hypothedcal protein FLJ11278 25
413976 BE295452 Hs 75655 procollagen-proline, 2-oxoglutarate 4-dι 25
445223 AW291553 Hs 254983 ESTs 25
423926 X03833 Hs 1722 interieukin 1, alpha 25
410165 BE560228 Hs 71869 apoptosis-associated speck-like protein 25
406474 25
433908 AW298141 Hs 157975 ESTs 25
439755 AW748482 Hs 77873 B7 homolog 3 25
437528 N59646 Hs 169745 cπimbs (Drosophila) homolog 1 25
420734 AW972872 Hs 293736 ESTs 25
415346 Z43108 gb HSC13E071 normalized infant brain cDN 25
419337 AW291112 Hs 209978 ESTs 25
444606 R09478 Hs 18041 ESTs 25
430061 AB037817 Hs 230188 KIAA1396 protein 25
413407 AI356293 Hs 75339 inositol polyphosphate phosphatase-like 25
411965 BE467339 Hs 280115 ESTs 25
409278 AA346683 Hs 52763 anaphase-promodng complex subunit 7 25
403142 25
401714 25
425081 X74794 Hs 154443 minichromosome maintenance deficient (S 25
416505 H66470 Hs 16004 ESTs 25
431518 AA743462 Hs 165337 ESTs 25
448623 BE613468 Hs 107515 ESTs, Weakly similar to T00329 hypothed 25
428301 AW628666 Hs 98440 ESTs, Weakly similar to I38022 hypothed 25
404366 25
449733 R74546 Hs 29438 Homo sapiens cDNA FLJ12094 fis, clone HE 25
459583 AI907673 gb IL-BT152-080399-004 BT152 Homo sapien 25
402856 AW939659 gb RCO-DT0076-110100-031-C09 DT0076 Homo 25
420751 J03019 Hs 99913 adrenergic, beta-1-, receptor 24
436805 AA731533 Hs 270751 ESTs 24
420285 AA258124 Hs 293878 ESTs, Moderately similar to ZN91_HUMAN Z 24
453496 AA442103 Hs 33084 solute earner family 2 (facilitated glu 24
453853 AL040600 Hs 188083 ESTs 24
407909 AW103986 gb xd63e06 x1 NCI CGAP Ov23 Homo sapiens 24
454630 BE142075 gb CM3-HT0137-170999-012-f02 HT0137 Homo 24
451026 AA013218 Hs 157492 cer-d4 (mouse) homolog 24
420779 L12398 Hs 99922 dopamine receptor D4 24
438322 AA804170 Hs 221349 ESTs 24
455908 BE156306 gb QVO-HT0367-150200-114-h04 HT0367 Homo 24
419625 U91616 Hs 91640 nuclear factor of kappa light polypepdd 24
440773 AA352702 Hs 332541 Homo sapiens, Similar to RIKEN cDNA 2700 24
450823 T81223 Hs 22011 complemeπt-c1q tumor necrosis factor-rel 24
447247 AW369351 Hs 287955 Homo sapiens cDNA FU13090 fis clone NT 24
429109 AL008637 Hs 196352 neutrophil cytosolic factor 4 (40kD) 24
451802 AI817711 Hs 209374 ESTs 24
419417 R92491 Hs 39429 ESTs 24
407094 AF000574 Hs 22405 leukocyte immunoglobulin like receptor, 24
423567 BE252949 Hs 69331 hypothedcal protein FU13633 24
427501 AI369280 Hs 131743 ESTs 24
451773 Z42044 Hs 26996 KIAA1278 protein 24
436845 AA732297 Hs 113928 ESTs 24
431584 AW296121 Hs 266263 Homo sapiens cDNA FLJ14115 fis, clone MA 24
440614 AA781530 Hs 127236 hypothedcal protein FLJ 12879 24
423721 AF176911 Hs 132004 cardiotrophin-like cytokine, neurotrophi 24
452125 BE312642 Hs 28077 GDP-manπose pyrophosphorylase B 24
419508 AW997938 Hs 90786 ATP-bindmg cassette, sub-family C (CFTR 24
453446 BE299996 gb 600944574F1 NIH MGC 17 Homo sapiensc 24
419792 AA250890 Hs 190037 ESTs 24
452786 R61362 Hs 106642 ESTs, Weakly similar to T09052 hypothed 24
410447 AW816134 gb MR3-ST0220-290100-016-e04 ST0220 Homo 24
438662 AA223599 Hs 6351 cleavage and polyadenylation specific fa 24
402408 24
443950 NM_001425 Hs 9999 epithelial membrane protein 3 24
414625 AA335738 Hs 76686 glutathione peroxidase 1 24
403048 24
432088 AA525454 gb nι85c09 s1 NCI_CGAP_Pr20 Homo sapiens 24
431692 AL021331 Hs 267749 unc93 (C elegans) homolog A 24
455023 AW850907 gb IL3-CT0220-310100-065-H11 CT0220 Homo 24
426249 F05422 Hs 168352 nucleoponn-like protein 1 24
446795 AI797713 Hs 156471 ESTs 24
414774 X02419 Hs 77274 plasminogen acdvator, urok ase 24
414252 AA346483 Hs 126191 ESTs 24
417918 AA209205 Hs 163754 hypothedcal protein FU 12606 24
427550 BE242818 Hs 179606 nuclear RNA helicase, DECD vanant of DE 24
404020 24
407846 AA426202 Hs 40403 Cbp/p300-ιnteracdng fransactivator, wit 24
417222 AI525424 Hs 42053 hypothedcal protein MGC2383 24
443639 BE269042 Hs 9661 proteasome (prosome, macropam) subunit 24
452706 AW449390 Hs 257150 ESTs, Moderately similar to SUR1.HUMAN S 24
401676 24
428882 AA436915 Hs 131748 ESTs. Moderately similar to ALU7_HUMAN A 24 436277 R88520 Hs 120917 ESTs 24
426271 AF026547 Hs 169047 chondroidn sulfate proteoglycan 3 (neur 24
405353 24
409193 AA131483 gb zo08e05 π Stratagene neuroepithelium 24
431431 AL096711 Hs 252953 Human DNA sequence from clone RP3-403A15 24
407889 R34556 Hs 30800 ESTs, Weakly similar to S65657 alpha-1C- 24
453335 AW857376 Hs 169238 fucosyltransferase 3 (galactoside 3(4)-L 24
450621 AW297288 Hs 55918 hypothedcal protein FU11354 24
419652 AL157485 Hs 91973 hypothetical protein 24
421151 BE174431 Hs 63386 ESTs 24
437846 AA773866 Hs 244569 esophagus cancer-related gene-2 24
420681 AA847602 Hs 106510 ESTs, Moderately similar to ALU2.HUMAN A 24
405288 24
453527 R49570 Hs 180236 ESTs 24
429875 AI091815 gb qa58b06 s1 Soares NhHMPu S1 Homo sapi 24
436360 AI962796 Hs 136754 ESTs 24
418592 X99226 Hs 284153 Faπconi anemia, complementadon group A 24
419991 AJ000098 Hs 94210 eyes absent (Drosophila) homolog 1 24
449539 W80363 Hs 58446 ESTs 24
419870 AW403911 Hs 266175 phosphoprotein associated with GEMs 24
404584 24
454276 AW294996 Hs 255374 ESTs 24
423746 AW361817 Hs 132370 NADPH oxidase 1 24
415558 AA885143 Hs 125719 ESTs 24
428141 D50402 Hs 182611 solute earner family 11 (proton-coupled 24
406953 L36847 gb Human (clone p17/90) rearranged iduro 24
444471 AB020684 Hs 11217 KIAA0877 protein 24
451031 AI360187 Hs 4254 ESTs 24
455302 AW997641 gb RC6-8N0052-170200-011-D06 BN0052 Homo 24
449063 AI627352 Hs 236547 Homo sapiens, clone IMAGE 2905978, mRNA, 24
401048 24
434420 AA688278 Hs 194864 hypothedcal protein FU22578 24
425848 BE242709 Hs 159637 valyl-tRNA synthetase 2 24
449086 AI628357 Hs 208037 ESTs 24
415238 R37780 Hs 21422 ESTs 24
448337 AW206453 Hs 3782 ESTs 24
416991 N36389 Hs 141296 KIAA0226 gene product 23
412600 1-28824 Hs 74101 spleen tyrosine kinase 23
418385 AW590613 Hs 301040 Homo sapiens, clone IMAGE 3357127, mRNA, 23
440769 BE561793 Hs 21446 KIAA1716 protein 23
450437 X13956 Hs 24998 hypothedcal protein MGC10471 23
412035 N78559 Hs 293629 hypothedcal protein MGC3121 23
406739 AI566709 Hs 182426 πbosomal protein S2 23
418506 AA084248 Hs 85339 G protein-coupled receptor 39 23
410286 AI739159 Hs 61898 DKFZP586N2124 protein 23
443740 R56434 Hs 21062 ESTs 23
405605 23
416913 AW934714 gb RC1 DT0001-031299-011-a11 DT0001 Homo 23
426509 M31166 Hs 2050 peπtaxm related gene, rapidly induced b 23
445828 F05802 Hs 81907 ESTs 23
457195 AB011099 Hs 196647 KIAA0527 protein 23
420372 AW960049 Hs 293660 Homo sapiens, clone IMAGE 3535476, mRNA, 23
423198 M81933 Hs 1634 cell division cycle 25A 23
457730 AW753613 gb RC1-CT0268-060100-013^01 CT0268 Homo 23
412014 AI620650 Hs 43761 ESTs, Weakly similar to A46010 X-linked 23
447131 NM_004585 Hs 17466 retinoic acid receptor responder (tazaro 23
446288 AW189209 Hs 149708 ESTs 23
436954 AA740151 Hs 130425 ESTs 23
411658 AW855598 gb CM1-CT0278-031199-032-e08 CT0278 Homo 23
404240 23
456094 H95091 gb yw57a09 r1 Soares_placenta_8to9weeks_ 23
416951 AA190926 Hs 190785 ESTs, Moderately similar to S65657 alpha 23
406737 AI356586 gb qy15h09 x1 NCI.CGAP Brn23 Homo sapien 23
458453 AI097452 Hs 135095 ESTs 23
452330 AI879127 Hs 191979 KIAA1733 protein 23
408523 AW833259 Hs 314287 ESTs 23
455470 AW947992 gb PMO-MT0011-240300-001-C09 T0011 Homo 23
436323 R17697 Hs 140963 ESTs, Weakly similar to 138022 hypothed 23
450000 AI952797 Hs 10888 hypothedcal protein FU21709 23
416171 H23896 Hs 125790 leucine-nch repeat-containing 2 23
419134 T89863 Hs 221771 ESTs 23
445933 AV655733 Hs 293860 spinster-like protein 23
422089 AA523172 Hs 103135 ESTs, Weakly similar to SFR4 HUMAN SPLIC 23
449911 AI262106 Hs 12653 ESTs 23
417079 U65590 Hs 81134 interieukin 1 receptor antagonist 23
411742 AW247593 Hs 71819 eukaryodc transladon initiation factor 23
435615 Y15065 Hs 4975 potassium voltage-gated channel, KQT-lik 23
423491 AA191765 Hs 129673 eukaryotic translation initiation factor 23
407182 AA312551 Hs 230157 ESTs 23
411448 AA178955 Hs 271439 ESTs, Weakly similar to I38022 hypothed 23
438644 AI126162 Hs 129037 ESTs 23
432691 U29725 Hs 3080 mitogeπ-acdvated protein kinase 7 23
452198 AI097560 Hs 61210 ESTs, Weakly similar to 138022 hypothed 23 411125 AA151647 Hs 68877 cytochrome b-245, alpha polypepdde 23
404054 23
430458 AA479300 Hs 225706 ESTs, Weakly similar to I38022 hypotheti 23
440210 AW674562 Hs 125296 ESTs 23
446727 AB011095 Hs 16032 KIAA0523 protein 23
453775 NM 002916 Hs 35120 replication factor C (activator 1) 4 (37 23
438379 N23018 Hs 171391 C-terminal binding protein 2 23
449919 AI674685 Hs 200141 ESTs 23
415293 R49462 Hs 106541 ESTs 23
441126 NM.000429 Hs 323715 methionine adenosyltransferase I, alpha 23
408203 AA053137 Hs 42390 nasopharyngeal carcinoma susceptibility 23
434941 AW073202 Hs 334825 Homo sapiens cDNA FU 14752 fis, done NT 23
450748 AI733093 Hs 130016 ESTs 23
404185 23
418327 U70370 Hs 84136 paired-like homeodomain transcnpdon fa 23
451370 AI791929 Hs 300782 ESTs 23
400034 23
407723 AW071161 Hs 252873 ESTs 23
431320 AW969474 Hs 183070 ESTs 23
429271 AF039850 Hs 198515 dead πnger (Drosophιla)-lιke 1 23
453707 AW003879 Hs 126522 Homo sapiens, clone MGC 16722, mRNA, com 23
419225 U70073 gb HSU70073 Human Homo sapiens cDNA don 23
444656 AI277924 Hs 145199 ESTs 23
405741 23
400917 23
432567 AA736777 Hs 293770 ESTs 23
437949 U78519 Hs 41654 ESTs, Weakly similar to A46010 X-linked 23
450514 AC005785 Hs 25059 A kinase (PRKA) anchor protein 8 23
418400 BE243026 Hs 301989 KIAA0246 protein 23
444019 BE173977 Hs 10098 putadve nucleolar RNA helicase 23
406326 23
412077 N51107 Hs 47199 ESTs, Weakly similar to FLJ00004 protein 23
427647 W19744 Hs 180059 Homo sapiens cONA FU20653 fis, clone KA 23
414528 AA148950 Hs 188836 ESTs 23
414854 BE546797 Hs 51483 ESTs, Weakly similar to hypothetical pro 23
420352 BE258835 gb 601117374F1 NIH MGC 16 Homo sapiens c 23
439467 AW292275 Hs 158365 ESTs 23
402627 23
451711 AK000461 Hs 26890 cat eye syndrome chromosome region, cand 23
424308 AW975531 Hs 154443 minichromosome maintenance deficient (S 23
423869 BE409301 Hs 134012 C1q-related factor 23
405915 23
431503 NM 012129 Hs 258576 claudin 12 23
423306 W88562 Hs 108198 ESTs 23
443232 AF161521 Hs 9081 phenylalanyl-tRNA synthetase beta-subuni 23
433064 D79991 Hs 30002 SH3oontaιnιng protein SH3GLB2, KIAA1848 23
434437 AI912566 Hs 187813 ESTs 23
436191 BE407866 Hs 170253 hypothedcal protein FLJ23282 23
420006 H14429 Hs 94300 serologically defined colon cancer andg 23
447942 F12628 Hs 334786 hypothedcal protein MGC16040 23
403166 23
422119 AI277829 Hs 111862 KIAA0590 gene product 23
403751 23
426451 AI908165 Hs 169946 GATA-bmding protein 3 23
427413 BE547647 Hs 177781 hypothetical protein MGC5618 23
409091 AW970386 Hs 269423 ESTs 23
440491 R35252 Hs 24944 ESTs, Weakly similar to 2109260A B cell 23
427722 AK000123 Hs 180479 hypothetical protein FU20116 23
405747 23
438210 AA780519 Hs 311601 EST 23
404652 23
423524 AF055989 Hs 129738 potassium voltage-gated channel, Shaw-re 22
426793 X89887 Hs 172350 HIR (histone cell cycle reguladon defec 22
44-1424 AI654684 Hs 196377 ESTs 22
434031 BE384165 Hs 23723 pseudouπdylate synthase 1 22
427650 AW501245 Hs 252259 πbosomal protein S3 22
435220 D50030 Hs 104 HGF acdvator 22
438279 AA805166 Hs 154762 HIV-1 rev binding protein 2 22
424668 D83702 Hs 151573 cryptochrome 1 (photolyase-like) 22
429961 BE246829 Hs 226770 DKFZP566C0424 protein 22
442065 AI831229 Hs 128417 hypothetical protein FU14009 22
415198 AW009480 Hs 943 natural killer cell transcπpt 4 22
420536 AL117455 Hs 275438 histone deacetylase 7A 22
411263 BE297802 Hs 69360 kmesin-like 6 (mitodc centromere-assoc 22
443753 AW367578 Hs 134749 ESTs 22
423243 AA351938 Hs 23964 sιπ3-assocιated polypepdde, 18kD 22
446572 AV659151 Hs 282961 ESTs 22
412247 AF022375 Hs 73793 vascular endothelial growth factor 22
421040 AA715026 Hs 135280 ESTs 22
426212 S71824 Hs 167988 neural cell adhesion molecule 1 22
455584 BE007420 gb PM3-BN0142-200300-001-C04 BN0142 Homo 22
406851 AA609784 Hs 180255 maior histocompadbility complex, class 22
444153 AK001610 Hs 10414 hypothedcal protein FU10748 22 419575 U43431 Hs 91175 topoisomerase (DNA) III alpha 22
418672 L44284 Hs 159743 ESTs 22
456261 AA210718 Hs 104157 ESTs. Weakly similar to KIAA0694 protein 22
415737 AA167626 Hs 118743 ESTs 22
447554 AI391598 Hs 36119 ESTs, Weakly similar to ALU1.HUMAN ALU S 22
405159 22
442177 AW661820 Hs 211413 ESTs 22
446139 H77395 Hs 39749 ESTs 22
458339 AW976853 Hs 172843 ESTs 22
401876 22
439566 AF086387 gb Homo sapiens full length insert cDNA 22
425079 H09963 Hs 2257 vitronecdn (serum spreading factor, som 22
441837 AA361743 Hs 179881 core-binding factor, beta subunit 22
430644 AB015419 Hs 247710 preproprolacdn-releasiπg peptide 22
431474 AL133990 Hs 190642 ESTs 22
407739 NM.002285 Hs 38070 lymphoid nuclear protein related to AF4 22
424244 AV647184 Hs 143601 hypothedcal protein hCLA-iso 22
438057 AW294544 Hs 125785 ESTs, Weakly similar to CORB MOUSE CORNI 22
412715 NM 000947 Hs 74519 pnmase, polypepdde 2A (58kD) 22
422365 AF035537 Hs 115521 REV3 (yeast homolog)-lιke, catalydc sub 22
404170 22
406902 M32074 gb Human rednoic acid receptor gamma 2 22
437902 AA770599 Hs 144055 ESTs 22
401012 22
446502 AI302654 Hs 208024 ESTs 22
442554 AW467376 Hs 129640 ESTs 22
443021 AA368546 Hs 8904 lg superfamily protein 22
421141 AW117261 Hs 125914 ESTs 22
443070 BE388662 Hs 8984 Homo sapiens chromosome 14 BAC 98L12 22
446566 H95741 Hs 17914 membrane-spanning 4-domaιns, subfamily A 22
427695 R88483 Hs 172862 ESTs 22
426503 AA380153 gb EST93093 Skin tumor I Homo sapiens cD 22
431468 AW248431 Hs 256526 nuclear prelamm A recognidon factor 22
416185 AW975861 Hs 47367 KIAA1785 protem 22
437319 BE410958 Hs 56406 Homo sapiens cDNA FU 13549 fis, clone PL 22
402064 22
413335 AI613318 Hs 48442 ESTs 22
408212 AA297567 Hs 43728 hypothedcal protein 22
406169 22
451099 R52795 Hs 25954 interieukin 13 receptor, alpha 2 22
407335 AA631047 Hs 158761 Homo sapiens cDNA FU13054 fis, clone NT 22
409715 W42591 Hs 23892 ESTs 22
431921 N46466 Hs 58879 ESTs 22
443823 BE089782 Hs 9877 hypothedcal protein 22
432458 AI968598 Hs 78768 malignant cell expression enhanced gene/ 22
419726 U50330 Hs 1274 bone morphogenedc protein 1 22
423178 AI033140 Hs 124983 Homo sapiens mRNA, cDNA DKFZp564C142 (fr 22
451089 AA903705 Hs 4190 Homo sapiens cDNA FU23269 fis, clone C 22
415216 AI825905 Hs 193211 Homo sapiens cDNA FU 11421 fis, ctone HE 22
442242 AV647908 Hs 90424 Homo sapiens cDNA FLJ23285 fis, clone H 22
441830 AA383104 Hs 42954 hypothetical protein DKFZp564D0372 22
406660 X65371 Hs 172550 polypynmidme tract binding protein (he 22
443378 AW392550 Hs 9280 proteasome (prosome, macropam) subunit. 22
432558 R97268 Hs 1 7269 ESTs 22
408146 R45621 Hs 81057 hypothedcal protein MGC2718 22
419865 NM 007020 Hs 93502 U1-snRNP binding protein homolog (70kD) 22
439444 AI277652 Hs 54578 ESTs, Weakly similar to I38022 hypothed 22
438407 AI457122 Hs 129673 eukaryotic translation initiation factor 22
450184 W31096 Hs 237617 Homo sapiens, clone IMAGE 3447394, mRNA, 22
409130 BE076601 Hs 75658 phosphorylase, glycogen, brain 22
428844 AW972635 Hs 301904 hypothetical protein FU12671 2 2
429489 AF008203 Hs 204039 aπstaless-like homeobox 3 22
433042 AW193534 Hs 281895 Homo sapiens cDNA FU 11660 fis clone HE 2 2
440658 H29142 Hs 143032 ESTs, Weakly similar to neuronal thread 22
408204 AA454501 Hs 43666 protein tyrosine phosphatase type IVA, 22
427498 NM 003926 Hs 178728 methyl-CpG binding domain protein 3 22
408006 H57654 Hs 303345 ESTs, Weakly similar to I38022 hypotheti 22
445703 AV654845 Hs 27 glycine dehydrogenase (decarboxyladng, 22
431446 AW294929 Hs 255369 Homo sapiens cDNA FU10265 fis, clone HE 22
456660 AA909249 Hs 112282 solute earner family 30 (zinc transport 22
433099 NM 002504 Hs 3187 nuclear transcnpdon factor, X-box bind 22
415857 AA866115 Hs 127797 Homo sapiens CDNA FU11381 fis, clone HE 22
415245 N59650 Hs 27252 ESTs 22
443657 R14973 gb yf42f10 s1 Soares fetal liver spleen 22
402521 AW501216 Hs 108945 KIAA0515 protein 22
414819 BE177320 Hs 1561 8 hypothedcal protein FU13231 22
446530 AV658909 Hs 282642 ESTs 22
415797 AI291896 Hs 72800 ESTs 22
414812 X72755 Hs 77367 monokine induced by gamma interferon 22
453028 AB006532 Hs 31442 RecQ protein-like 4 22
412133 U83460 Hs 73614 solute earner family 31 (copper transpo 22
407881 AW072003 Hs 40968 heparan sulfate (glucosamine) 3-O-sulfot 22
437033 AW248364 Hs 5409 RNA polymerase 1 subunit 22 422732 AA577455 Hs 24937 traπsfonner-2 alpha (htra-2 alpha) 22
416388 AI417358 Hs 73677 ESTs 22
452849 AF044924 Hs 30792 hook2 protein 22
446615 BE513202 Hs 15589 PPAR binding protein 22
428361 NM 015905 Hs 183858 transcπptional intermediaiγ factor 1 22
446279 AA490770 Hs 182382 ESTs 22
422938 NM.001809 Hs 1594 centromere protein A (17kD) 22
403969 22
410423 AW402432 Hs 63489 protein tyrosine phosphatase, non-recept 22
429736 AF125304 Hs 212680 tumor necrosis factor receptor superfami 22
447091 AW089648 Hs 157779 ESTs, Weakly similar to CA17.HUMAN COLLA 22
422017 NM.003877 Hs 110776 STAT induced STAT ιnhιbιtor-2 22
426728 NM 007118 Hs 171957 tπple fuπcdonal domain (PTPRF interact 22
438726 AB033103 Hs 6385 KIAA1277 protein 22
453315 BE544203 Hs 24831 ESTs 22
423244 AL039379 Hs 209602 ESTs, Weakly similar to ubiquitous TPR m 22
433610 AA806822 Hs 112547 ESTs 22
429451 BE409861 Hs 202833 heme oxygenase (decycling) 1 22
417980 R32235 gb yh67f08 r1 Soares placenta Nb2HP Homo 22
406347 22
414406 BE297904 gb 601177814F1 NIH_MGC.17 Homo sapiens c 22
401827 22
446913 AA430650 Hs 16529 transmembrane 4 superfamily member (tetr 22
452294 AI871925 Hs 117895 ESTs, Moderately similar to A47582 B-cel 22
404084 22
456786 AK002084 Hs 132851 hypothedcal protein FU 11222 22
435031 AI632091 Hs 116877 ESTs 22
442609 AL020996 Hs 8518 selenoprotein N 21
439732 AW629604 Hs 167641 hypothedcal protein from EUROIMAGE 1703 21
421506 BE302796 Hs 105097 thymidine kinase 1 soluble 2 1
439253 AF086064 Hs 332252 ESTs 21
409669 AW177551 Hs 220255 hypothedcal protein MGC13098 21
429574 BE268321 Hs 208912 hypothetical protein MGC861 2 1
437470 AL390147 Hs 134742 hypothedcal protein DKFZp547D065 21
408945 AW015089 Hs 4964 DKFZP586J1624 protein 2 1
447687 AI627947 Hs 150186 hypothedcal protein DKFZp566K1946 2 1
459584 AI910884 Hs 207898 ESTs 21
439130 AA306090 Hs 124707 ESTs 2 1
428180 AI129767 Hs 182874 guanine nudeodde binding protein (G pr 2 1
442028 AI239437 Hs 48945 ESTs 2 1
430968 AW972830 gb EST384925 MAGE resequences, MAGL Homo 2 1
443609 AV650231 Hs 282941 ESTs, Highly similar to A Chain A, Human 21
417164 AA338283 Hs 81361 heterogeneous nuclear πbonucleoprotein 2 1
444534 AW271626 Hs 42294 ESTs 2 1
438391 AI262248 Hs 25027 ESTs 2 1
442003 AW297497 Hs 201891 ESTs 2 1
456278 BE300369 Hs 289038 hypothetical protein MGC4126 2 1
416976 BE243985 Hs 80680 mapr vault protein 2 1
417810 D28419 Hs 82609 hydroxymethylbilane synthase 2 1
445242 BE156478 Hs 21108 ESTs, Weakly similar to ALU1 HUMAN ALU S 21
452712 AW838616 gb RC5-LT0054-140200-013-O01 LT0054 Homo 2 1
434926 BE543269 Hs 50252 mitochondπal nbosomal protein L32 2 1
421564 AB007864 Hs 105850 KIAA0404 protein 2 1
424927 AW973666 Hs 153850 hypothedcal protein C321D24 2 1
432742 AA564453 Hs 162339 ESTs 2 1
435958 H98180 Hs 117975 ESTs 2 1
421531 AA713505 Hs 291769 ESTs 21
410431 BE261320 Hs 158196 traπscπpdonal adaptor 3 (ADA3, yeast h 2 1
420503 AI570943 Hs 337546 ESTs 21
448127 AI478416 Hs 282883 ESTs, Weakly similar to ALU1.HUMAN ALU S 2 1
452897 BE066058 Hs 269233 ESTs, Moderately similar to I78885 seπn 2 1
447112 H17800 Hs 7154 ESTs 21
406577 2 1
437162 AW005505 Hs 5464 thyroid hormone receptor coacdvadng pr 2 1
451460 AI797550 Hs 209652 ESTs 2 1
447402 H54520 Hs 18490 hypothedcal protein FU20452 2 1
435828 AA700705 Hs 13852 ESTs 2 1
436396 AI683487 Hs 152213 wingless-type MMTV mtegradon site fami 2 1
420582 BE047878 Hs 99093 Homo sapiens chromosome 19, cosmid R2837 2 1
452020 AA722012 Hs 255757 ESTs, Weakly similar to AT2A_HUMAN POTEN 2 1
415586 Z45481 gb HSC2QE041 normalized infant brain cDN 2 1
452620 AA436504 Hs 119286 ESTs 2 1
457066 BE244613 Hs 158272 ESTs, Weakly similar to CA13 MOUSE COLLA 2 1
435472 AW972330 Hs 283022 tπggeπng receptor expressed on myeloid 2 1
431741 AA514783 Hs 191701 ESTs 2 1
446840 AW294828 Hs 209203 ESTs 21
440818 AI147060 Hs 146726 ESTs 2 1
410174 AA306007 Hs 59461 DKFZP434C245 protein 2 1
400822 2 1
412760 AW379030 Hs 41324 ESTs 2 1
410653 BE383768 Hs 65238 95 kDa rednoblastoma protein binding pr 2 1
426925 NM 001196 Hs 315689 Homo sapiens cONA FU22373 (is, clone H 2 1
424242 AA337476 Hs 293984 hypothetical protein MGC13102 2 1 452560 BE077084 Hs 336432 ESTs 21
456437 AI924228 Hs 115185 ESTs, Moderately similar to PC4259 fern 2 1
458922 BE501831 Hs 282053 ESTs 21
439231 AW581935 Hs 141480 Homo sapiens mRNA, cONA DKFZp434N079 (fr 2 1
419488 AA316241 Hs 90691 nucleophosmin/nucleoplasmin 3 21
411829 AW865749 gb QV3-SN0021-100500-185-C03 SN0021 Homo 2 1
457192 AL135682 Hs 22452 Homo sapiens mRNA for KIAA1737 protein, 21
422128 AW881145 gb QV0-OT0033-010400-182 a07 OT0033 Homo 21
452571 W31518 Hs 34665 ESTs 21
423699 H41850 Hs 131846 PCAF associated factor 65 alpha 2 1
406610 21
453638 AW814996 gb MR1-ST0206-170400-024-h09 ST0206 Homo 2 1
418856 AA362858 gb EST72900 Ovary II Homo sapiens cDNA 5 21
437623 D63880 Hs 5719 chromosome condensadon-related SMC-asso 2 1
410908 AA121686 Hs 10592 ESTs 21
420221 N25991 Hs 43725 ESTs 2 1
424739 AA346108 Hs 221610 ESTs 21
425398 AL049689 Hs 156369 hypothedcal protein similar to tenascin 21
424901 Z11933 Hs 182505 POU domain, class 3, transcnpdon facto 21
411096 U80034 Hs 68583 mitochondπal intermediate pepddase 21
415635 F13168 gb HSC3JF101 normalized infant brain cDN 2 1
418181 U37012 Hs 83727 cleavage and polyadenyladon specific fa 21
407103 AA424881 Hs 256301 hypothedcal protein MGC13170 2 1
454389 AW752571 gb IL3-CT0213-170100-055-F02 CT0213 Homo 21
400021 21
439228 N51700 gb y72d01 s1 Soares muldple sclerosis 21
456505 AA504595 Hs 111418 ESTs 2 1
405258 21
444645 AI184564 Hs 101654 ESTs 2 1
430246 AI269069 Hs 109268 hypothetical protein FU 12552 21
458687 AW024815 Hs 170088 GLUT4 enhancer factor 2 1
403857 21
400258 21
422221 AA306649 Hs 169370 FYN oncogene related to SRC, FGR, YES 2 1
441054 AA913591 Hs 126480 ESTs 2 1
452700 AI859390 Hs 288940 five-span transmembrane protein M83 21
454606 AW809752 gb MR4-ST0124-181299-020-b06 ST0124 Homo 2 1
448954 AB014564 Hs 22616 KIAA0664 protein 2 1
443148 AI034357 Hs 211194 ESTs, Weakly similar to ALU8_HUMAN ALU S 21
453486 AL039201 Hs 173554 ubiquinol-cytochrome c reductase core pr 21
437695 AA769202 Hs 192142 ESTs 2 1
425449 X52056 Hs 157441 spleen focus forming virus (SFFV) provir 2 1
447270 AC002551 Hs 331 general transcnpdon factor IIIC, polyp 2 1
435677 AA694142 Hs 293726 ESTs, Weakly similar to TSGA RAT TESTIS 2 1
436382 AW977063 Hs 250181 ESTs 2 1
435837 AI689210 Hs 187276 Homo sapiens cDNA FU 11431 fis, clone HE 21
458287 AA987556 Hs 12867 ESTs 2 1
423794 BE551781 Hs 231895 ESTs 21
408049 AW076098 Hs 74316 desmoplakin (DPI, DPII) 21
402721 21
451999 AW176401 Hs 27424 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 2 1
417541 AI992191 Hs 180040 hypothetical protein FLJ22439 21
414857 AW402389 Hs 920 modulator recognidon factor 1 2 1
435760 AF231922 Hs 213004 chromosome 21 open reading frame 62 21
428086 AL110193 Hs 224137 hypothetical protein 21
447853 AI434204 Hs 164285 ESTs, Weakly similar to AFG1_YEAST AFG1 21
419034 NM 002110 Hs 89555 hemopotetic cell kinase 2 1
431019 NM 005249 Hs 2714 forkhead box GIB 21
421064 AI245432 Hs 101382 tumor necrosis factor, alpha-induced pro 2 1
416435 AI431301 Hs 179703 KIAA0129 gene product 21
437014 AA808757 Hs 222531 ESTs, Weakly similar to S59501 interfero 2 1
459369 T83080 gb yd40e03 r1 Soares fetal liver spleen 21
402239 21
412280 AW205116 Hs 272814 hypothetical protein DKFZp434E1723 21
426012 AA367507 Hs 75874 pregnancy-associated plasma protein A 2 1
438885 AI886558 Hs 184987 ESTs 21
426076 AW962714 gb EST374787 MAGE resequences, MAGG Homo 2 1
404561 21
442932 AA457211 Hs 8858 bromodomain adjacent to zinc finger doma 21
408175 W29089 Hs 19066 hypothetical protein DKFZp66702416 21
423867 AA331886 gb EST35757 Embryo, 8 week I Homo sapien 2 1
458604 W37944 Hs 4007 Sarcolemmal-associated protein 21
409650 T08490 Hs 288969 HSCARG protein 2 1
401729 21
433675 AW977653 Hs 5319 πbonucleodde reductase M2 polypepdde 2 1
456741 W37608 Hs 184492 ESTs 21
417037 BE083936 Hs 80976 antigen identified by monoclonal andbod 2 1
415079 R43179 Hs 22895 hypothetical protein FLJ23548 21
439262 AA832333 Hs 333045 ESTs 2 1
403108 21
436718 AW015227 Hs 289053 hypothedcal protein FLJ 14733 2 1
440696 AI762757 Hs 187660 putative Rab5 GDP/GTP exchange factor ho 21
409745 AA077391 gb 7B14E12 Chromosome 7 Fetal Brain cDNA 2 1 453485 BE620712 Hs 33026 hypothetical protein PP2447 2 1
418177 N44967 Hs 5663 ESTs 2 1
457292 AI921270 Hs 334882 hypothedcal protein FU14251 2 1
454434 AA083558 Hs 261286 ESTs 2 1
406085 2 1
424441 X14850 Hs 147097 H2A histone family, member X 2 1
422726 U11690 Hs 1572 faciogenital dysplasia (Aarskog-Scott sy 2 1
424576 BE154142 Hs 96833 ESTs 2 1
423660 AL045228 Hs 130831 Homo sapiens mRNA, cDNA DKFZp434L137 (fr 2 1
403509 AF231919 Hs 18759 KIAA0539 gene product 2 1
441940 AW298115 Hs 128152 ESTs 2 1
439190 AW978693 Hs 293811 ESTs 2 1
417791 AW965339 Hs 111471 ESTs 2 1
423701 AA329856 Hs 143022 ESTs 2 1
427239 BE270447 Hs 174070 ubiquitin earner protein 2 1
459642 BE243103 gb TCAAP2E0949 Pediatπc acute myelogeno 2 1
450385 AI631024 Hs 24948 synuclein, alpha interacting protein (sy 2.1
425159 NM_004341 Hs 154868 carbamoyl-phosphate synthetase 2, aspart 2 1
425591 AW294734 Hs 279727 Homo sapiens cDNA FU 14035 fis, clone HE 2 1
445101 T75202 Hs 12314 Homo sapiens mRNA, cDNA DKFZp586C1019 (f 2 1
412811 H06382 Hs 21400 ESTs 2 1
426369 AF134157 Hs 169487 Kreisler (mouse) maf-related leucine zip 2 1
435924 AW029203 Hs 191952 ESTs 2 1
418388 R72332 Hs 29258 Homo sapiens cDNA FU 11364 fis, done HE 2 1
452235 AL039743 Hs 28514 testes development-related NYD-SP21 2 1
452313 Y00486 Hs 28914 adenine phosphoπbosyltransferase 2 1
450704 H85157 Hs 40696 ESTs 2 1
427539 AA405205 Hs 97960 ESTs, Weakly similar to T51146 nng-box 2 1
402028 2 1
405362 2 1
414718 H95348 Hs 107987 ESTs 2 1
433424 R68252 Hs 163566 ESTs 21
444875 AI200759 Hs 44737 ESTs 20
449523 NM 000579 Hs 54443 chemokine (C-C modf) receptor 5 20
456072 H54381 gb yq89a03 s 1 Soares fetal liver spleen 20
436331 AI239495 Hs 120189 ESTs 20
448418 Z43704 Hs 21192 Homo sapiens clone 25155 mRNA sequence 20
447250 AI878909 Hs 17883 protein phosphatase 1G (formerly 2C), a 20
448192 R43915 Hs 4958 ESTs 20
448966 AW372914 Hs 86149 phosphoinositol 3-phosphate-bιndιng prot 20
408605 AF025374 Hs 46465 T-cell, immune regulator 1 20
410790 AW803357 gb IL2-UM0079O90300-050-A08 UM0O79 Homo 20
436872 X15624 gb Human H1 RNA 20
432238 AL133057 Hs 274135 Homo sapiens mRNA, cONA OKFZp434K1815 (f 20
446307 T50083 Hs 9094 ESTs 20
436588 AA759233 Hs 126506 ESTs 20
452487 AW207659 Hs 6630 Homo sapiens cDNA FU 13329 (is, clone OV 20
430420 AW140027 Hs 26373 Homo sapiens cDNA FU23449 fis, clone H 20
432036 AF224266 Hs 272373 interieukin 20 20
414460 L00727 Hs 898 dystrophia myotonica-proteiπ kinase 20
433507 AI817336 Hs 191791 ESTs 20
427964 AA418082 Hs 98286 ESTs, Weakly similar to T20655 hypothed 20
443108 W86975 Hs 203707 ESTs 20
434504 AI887341 Hs 121590 hypothedcal protein FU12827 20
454310 AW818390 Hs 175613 homolog of Xenopus Claspin 20
443566 AI290284 Hs 159872 ESTs 20
449722 BE280074 Hs 23960 cyclin B1 20
452682 AA456193 Hs 9071 progesterone membrane binding protein 20
412362 AW945484 Hs 184252 ESTs, Weakly similar to ALU8_HUMAN ALU S 20
429341 X73874 Hs 2393 phosphorylase kinase, alpha 1 (muscle) 20
435863 AF255346 Hs 62919 Jun dimenzadon protein p21SNFT 20
400774 R58624 Hs 2186 eukaryodc translation elongation factor 20
453944 AW975369 Hs 292570 Homo sapiens, clone IMAGE 3502107, mRNA, 20
419227 BE537383 Hs 89739 cholinergic receptor, nicodnic, beta po 20
448529 T26460 Hs 22550 ESTs 20
443206 AB011420 Hs 9075 senne/threonme kinase 17a (apoptosis-i 20
439360 AA448488 Hs 336629 πbosomal protein L44 20
436660 AI658870 Hs 184513 ESTs 20
449030 AI365582 Hs 57100 Homo sapiens mRNA for FU00016 protein, 20
411048 AK001742 Hs 67991 hypothedcal protein DKFZp434G0522 20
406624 AF052762 gb Homo sapiens clone csneg8-1 immunoglo 20
450666 T99968 Hs 18799 ESTs, Weakly similar to I38022 hypothed 20
446143 BE245342 Hs 306079 sec61 homolog 20
437698 R61837 Hs 7990 ESTs Moderately similar to 184505 calci 20
426607 AA382330 Hs 124223 ESTs 20
449246 AW411209 Hs 23363 hypothedcal protein FU10983 20
422564 AI148006 Hs 222120 ESTs 20
432682 AI376400 Hs 159588 ESTs 20
422140 BE295918 Hs 112193 utS (E coli) homolog 5 20
408215 BE614290 Hs 43812 syntaxin 10 20
417129 AI381800 Hs 300684 calcitonin gene-related pepdde-receptor 20
442772 AW503680 Hs 5957 Homo sapiens clone 24416 mRNA sequence 20
434928 AW015595 Hs 4267 Homo sapiens clones 24714 and 24715 mRNA 20 411380 AW841619 gb RC1-CN0017-120200-012-b09 CN0017 Homo 20 430603 AA148164 Hs 247280 HBV associated factor 20 425905 AB032959 Hs 318584 novel C3HC4 type Zinc finger (πng finge 20 401125 20 412939 AW411491 Hs 2186 eukaryodc transladon elongation factor 20 448740 BE250632 Hs 8026 sestnn 2 20 454390 AB020713 Hs 56966 KIAA0906 protein 20 415012 NM_004383 Hs 77793 c-src tyrosine kinase 20 410407 X66839 Hs 63287 carbonic anhydrase IX 20 403478 20 456485 AI393037 Hs 97871 Homo sapiens, done IMAGE 3845253, mRNA, 20 430294 AI538226 Hs 32976 guanine nudeodde binding protein 4 20 411669 BE612676 Hs 303116 tromal cell-derived factor 2-lιke 1 20 451944 AW445218 Hs 210876 ESTs 20 436395 AJ22790O gb Homo sapiens partial mRNA, ID EE2-16B 20 456457 AA252905 Hs 194477 E3 ubiquidn ligase SMURF2 20 449123 D50920 Hs 23106 KIAA0130 gene product 20 409214 AW405967 Hs 333388 Homo sapiens, done IMAGE 3957135, mRNA, 20 437619 AW351491 Hs 334853 hypothedcal protein FU23544 20 453348 BE272318 Hs 8595 hypothedcal protem FU12438 20 424382 AA351898 Hs 23539 ESTs 20 447079 AA280057 Hs 105280 ESTs, Weakly similar to dJ963K232 [H sa 20 449501 AI652924 Hs 231942 ESTs 20 422893 X98411 Hs 121555 myosin IF 20 412125 Y17114 Hs 73393 eyes absent (Drosophila) homolog 4 20 434845 BE267057 Hs 325321 hypothedcal protein R32184 20 410422 AL042014 Hs 334698 Homo sapiens, clone MGC 15203, mRNA, com 20 430255 AK000703 Hs 323822 Homo sapiens mRNA for KIAA1551 protein, 20 451656 BE327088 Hs 212752 ESTs 20 442068 BE312873 Hs 314932 ESTs 20 446846 AW197626 Hs 271901 ESTs, Moderately similar to S08686 finge 20 442690 AI014727 Hs 160047 ESTs, Weakly similar to B28096 lιne-1 pr 20 454277 AW295069 Hs 31743 ESTs, Weakly similar to Z157_HUMAN ZINC 20 426910 AA470023 Hs 190089 ESTs Moderately similar to ALU1.HUMAN A 20 402798 20 404554 20
TABLE 25B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
407909 1025254.1 AW103986 BE156395 BE156391 BE156190 BE156184 BE156388 BE156394
408432 1058667.1 AW195262 R27868AW811262
409193 110747.1 AA131483 AA065156 AA076448
409745 115237.1 AA077391 AI347618AI361453AI088754AW207491 AW960912AA921874AA286833AA150722 BE152353AW188822 BE152450
410447 1203929.1 AW816134 BE063456 AW748795 BE150839
410790 1221131.1 AW803357 AW803423 AW812233 R06814
411256 1236790.1 AW834039 AW834040 AW834047 AW845410 BE003128 AW852479
411380 1242343.1 AW841619 AW851958 AW851851 AW851985
411632 1252361.1 AW854829 AW854805 AW854841 AW854825 AW854822 AW854830 AW854835 AW854826
411658 1252987.1 AW855598 AW855608 BE148763 BE148764 AW855645 AW855615 AW855596 AW855610 AW855601 AW855605
411829 1260309.1 AW865749 BE179419 BE179492
412225 1284108.1 AW902042 N77591
412370 1291952.1 AW946614 AW946622 AW946663 AW946667 AW946615 AW946619
412391 1292625.1 AW947710 AW947698 AW947697 AW947713
413257 1355963 1 BE075035 BE074999 BE075006 BE075005 BE075032 BE07S008 BE075037
413604 1379715.1 R51767 BE152515 Z44834 H23397
414406 1443333.1 BE297904 BE294312
414550 1460990.-1 BE379808
415346 1534581.1 Z43108 F06295 R13085
415406 1536026.1 T26510 F07926 R53367
415586 1540116.1 Z45481 F12393 T74437
415635 1540853 1 F13168 R21289 T77628
416871 1626761.1 H98716 N90792 N24283
416913 163001.1 AW934714 BE161007 BE162500 AW749902 AW749864 BE162498 BE161005 AA190449 AW513465 BE161006 BE162499
417980 1712954.1 R32235 R32247 R32219
418333 173 2 W92113 AA702794 BE044316 W91984 AA679375 T94184 AA679335 BE503126 AW502118 BE467367 AA584550 AW139964 R93353 AW088477
AI887846 AW502624 W81697 W81696 AA447817 AA447667 F13631 AW268271 AA055366 AW629027 AA677404 AA831618 AI124782 AA889402
AA765804 AA765530 AA055698 AA594019 AI267368 AA456946 R93354 AF264624 AW668618 AA601493
418856 179649.1 AA362858 AW863761 AA229428 419217 182954.1 AA504571 AA235243 AA411737 AW969068 AA406543 419225 1830274.-1 U70073 419311 183793.1 AA689591 AW974261 AA236240 AI077451 AA631399AW974262 420352 192979.1 BE258835 AW968316 AA258918 AW843305 R14744 AI580388 BE071923 R36280 422128 211994 1 AW881145 AA490718 M85637 AA304575 T06067 AA331991 422156 212379.1 N34524 AA305071 AW954803 AA502335 AI433430 AI203597 AW026670 AW265323 AW850787 AA317554 AW993643 AW835572 AW385512
AI334966 W32951 H62656 H53902 R88904 AW835732
422176 212714.1 H80977 BE147695 AA305496 AW962366 AA436754 423756 231725.1 AA828125 AA834883 AA330555 423867 232732.1 AA331886 AW962659 AW962655 T89841 425189 247825.1 H16622 R17322 AA351959 425517 2527291 AF121179 BE162736 AA358827
426076 2605041 AW962714 AA369277 AA369278
426413 2666501 AA377823 AW954494 AI022688
426503 2682831 AA380153 AA380233 AW963529
426531 2687601 AA381071 AA381084 AA380862
429875 3100341 AI091815 AA460162 AA460761
430968 3262691 AW972830 AA527647 AA489820 AA570362
432088 3411951 AA525454 H74039 R89502 T77379
433532 3689501 AW975367 AA598607 AA742735
434559 388891 AF147315 AW173079 T53029
435065 3993291 BE064391 BE064395 AA663613 N99644
436190 415551 AK001059 AA633055
436395 419051 AJ227900 AI094933 AW051119 F00947
436532 4218021 AA721522 AW975443 T93070
436722 4257581 AW975977 AA729469 AA747132
436872 42851 -1 X15624
437034 4317131 AA742643 AA808575 AW976668
439086 468521 AF085947 H70981 H78989
439228 47001 1 N51700AF086051 N51792
439518 473341 W76326AF086341 W72300
439546 473601 AF088056 W76297 W72448
439566 473871 AF086387 W77884 W72711
439710 475501 AF086543 W96291 W96225
443657 5766851 R14973 R14967 AI081006
444168 5938291 AW379879 AI126285 H12014
444386 604004.1 BE065183 AI144398 BE065367
451129 8598701 8E072881 BE072946 AI762181
452712 9283091 AW838616 AW838660 BE144343 AI914520 AW888910 BE184854 BE184784
453446 9675331 BE299996 BE297115 BE270415 BE295214 BE296526
453638 9756491 AW814996AL047199AW850979
453746 979731 1 AL120611 BE006190 BE006189
454377 114761 1 AA076811 AW814764
454389 1156821 AW752571 AW847602 AA077979
454606 12261492 AW809752 AW810271 AW809944 AW810319 AW810215 AW810368 AW810167
454630 1227352.1 BE142075 BE142148 BE142189 AW816249 BE142147 BE142002 BE142406 BE142094 BE142020 BE142074 BE142347 BE142000 BE142375
AW811189 BE142133
454631 12274431 AW811324AW811325AW811326 AW811333 AW811329 AW811328 AW811332AW811339 AW811335
454679 12289291 AW813110 AW813113
454967 1247021 1 AW848276 AW848416 AW848160 AW847945 AW847947 AW848063 AW848113
455023 12491881 AW850907 AW850901 AW850877
455302 12765421 AW997641 AW891777
455470 1292849.1 AW947992 AW947967 AW947950 AW947957 AW947953 AW947973 AW947966 AW947971 AW947947 AW947970 AW947995 AW947979 AW947952
AW947956
455514 13216491 AW983871 BE090302 AW983867 AW983845 AW983860 AW983853 AW983852
455530 1322298.1 AW984744 AW984759
455584 1334741 1 BE007420 BE007419 BE007421 BEO07422
455778 13645061 BE088746 BE088802 BE088755 BE088876 BE088947 BE088881 BE088952
455908 1382301 1 BE156306 BE156188 BE156298 BE156377 BE156374
456072 14702561 H54381 H54463 BE393262
456094 1504780.1 H95091 C01228
457374 3287581 AA493662 AW897396 BE154814
457578 359618 -1 AA578027
457730 3939051 AW753613 AW753857 BE150374 BE150693 BE150394 AA808851 AA650159 AA654653 BE150419
TABLE 25C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publication endded "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposition Indicates nudeodde posidons of predicted exons
Pkey Ref Strand Nt_posιdon
400822 7465000 Plus 186223-186402,186878-187275
400859 9757499 Minus 91888-9201898131-98294,99474-99570
400917 7283186 Minus 173258-173631
400992 8096828 Plus 140390-140822
401012 7230838 Minus 736-1137
401048 7232177 Plus 132430-132761
401125 8570296 Minus 126863-126984
401324 9863791 Plus 234057-234174
401384 6850939 Minus 58360-58545
401558 7139678 Plus 103510-104090
401626 8575943 Minus 238100-238432
401676 9965536 Plus 3891-4691
401714 6715702 Plus 96484-96681
401729 8134856 Minus 90651-90878
401827 2262095 Plus 94725-94860,98452-98660
401876 8099107 Plus 95913-96641
402028 7139781 Plus 88749-89237
402064 8117294 Plus 100159-100350,100445-100912
402239 7690131 Plus 38175-38304,42133-42266
402408 9796239 Minus 110326-110491
402424 9796344 Minus 64925-65073 402516 9798099 Minus 195342-195511
402604 9909420 Plus 20393-20767
402627 9931216 Plus 12136-12272,16487-16628,17654-17798,18494-18621,18933-19089,20669-2079021134-21298,22866-22973,23686-23820,26626- 2689529279-29469
402721 8969253 Minus 144428-144715
402798 3355547 Plus 23596-23867
402856 9801288 Minus 90119-90411
403048 4210991 Plus 44275-44592,49656-49955
403108 8980955 Plus 93253-93667
403142 9444521 Plus 89286-90131
403166 9838127 Minus 67762-67940,68695-68856,70394-70507
403478 9958258 Plus 116458-116564
403680 7331517 Minus 157184-157415
403751 7229815 Minus 158794-160929
403790 8084957 Minus 87826-87947,89835-90002
403797 8099896 Minus 123065-125008
403857 7708910 Minus 2524-3408
403881 7710245 Minus 107250-107685,108924-109213
403961 7596976 Minus 110393-110603
403969 8569909 Plus 31237-31375,32405-32506
404020 8655966 Minus 174449-174663
404054 3548785 Plus 66713-69175
404084 9944055 Plus 2795-2969
404108 8247074 Minus 63603-64942
404170 9930793 Plus 168836-169248
404185 4572584 Minus 129171-129327
404240 5002624 Minus 116132-116407,116653-116922
404295 9856663 Minus 75747-75947
404299 5738652 Minus 3826-4025
404366 9964977 Plus 96589-96801
404554 7243881 Plus 42637-42839
404561 9795980 Minus 69039-70100
404584 9857511 Plus 138651-139153
404589 9931665 Minus 32824-32985
404642 9796810 Plus 102999-103145
404652 9796969 Minus 108172-108296
404721 9856648 Minus 173763-174294
404756 7706327 Plus 82849-83627
404802 4581357 Minus 30093-30600
404984 6939882 Plus 87221-87505
405159 9966252 Plus 79659-79804
405258 7329310 Plus 129930-130076
405288 6139075 Minus 126268-126436
405353 2811095 Plus 118525-118892
405362 2337862 Minus 105008-105142,105980-106091,140445-140556,142519-142641
405558 1621110 Plus 4502-4644,5983-6083
405588 5002511 Plus 46180-46366
405605 5836195 Minus 117070-117270
405701 4263751 Plus 93243-93364
405741 9966947 Minus 156747-156875,156936-157208
405747 8469069 Minus 153933-154060
405771 7018349 Plus 91191-91254,91510-91589
405808 9929207 Plus 109758-111166
405884 6758747 Plus 62383-62583
405915 7712162 Minus 43717-43859
406028 8312303 Minus 177469-177829
406085 9123888 Plus 18665-18843
406169 6684220 Minus 12620-14251
406267 7528342 Minus 2570-2731
406326 9212385 Plus 84508-84655
406347 9255981 Plus 90900-91091
406474 9795567 Plus 52758-53211
406577 7711730 Plus 11377-11509
406610 8312226 Plus 13096-13334
TABLE 26A ABOUT 582 GENES SIGNIFICANTLY DOWN-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS TISSUES Table 26A lists about 582 genes significantly down-regulated in glioblastoma compared to nomial adult CNS dssues These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip anay such that the rado of "average* normal CNS to "average" glioblastoma was greater than or equal to 3 The "average* normal CNS level was set to the 75°' percendle amongst vanous normal CNS dssues The 'average* glioblastoma level was set to the βS* percendle amongst vaπous tumor samples In order to remove gene- specific background levels of non-specific hybndization, the 10 percendle value amongst vaπous non-malignant dssues was subtracted from both the numerator and the denominator before the ratio was evaluated Pkey Unique Eos probeset identifier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dde
R1 Ratio of 75"1 percendle normal central nervous system dssue to 851" percendle tumor
Pkey ExAccn UnigenelD Unigene Tide R1
453655 AW960427 Hs 79059 transforming growth factor, beta recepto 136 7
417275 X63578 Hs 295449 parvalbumin 290
430829 AW451999 Hs 194024 ESTs 257
410657 AF063228 Hs 65248 dynem, cytoplasmic intermediate polype 226 419954 D14720 Hs 93883 myelin protein zero (Charcot-Maπe-Tooth 21 2
459247 N46243 Hs 110373 ESTs, Highly similar to T42626 secreted 18 5
416133 NM 001683 Hs 89512 ATPase. Ca++ transporting, plasma membra 155
416018 AW138239 Hs 78977 proprote convertase subdlisin/kexin t 15 2
417167 AW206437 Hs 4290 ESTs 148
433940 H05129 Hs 7459 cyclic AMP-regulated phosphoprotein, 21 134
413324 V00571 Hs 75294 corticotropin releasing hormone 13 1
439830 AA846666 Hs 151489 ESTs, Weakly similar to XE7 HUMAN PROTEI 126
408068 AW148652 Hs 167398 ESTs 126
412636 NM 004415 Hs 74316 desmoplakiπ (DPI, DPII) 12 5
429096 AB011106 Hs 196012 KIAA0534 protein 12 2
412638 AA910199 Hs 203838 ESTs 122
423690 AA329648 Hs 23804 ESTs, Weakly similar to PN0099 son3 prot 12 1
456844 AI264155 Hs 152981 CDP-diacykjIycerol synthase (phosphadda 11 9
418318 U47732 Hs 84072 transmembrane 4 superfamily member 3 109
442593 R39804 Hs 31961 ESTs 108
446353 AI290919 Hs 153661 ESTs 104
420290 AW977318 Hs 194480 ESTs 103
414220 BE298094 gb 601118231F1 NIH MGC 17 Homo sapiens c 103
414290 AI568801 Hs 71721 ESTs 10 2
426365 AA376667 Hs 10283 RNA binding modf protein 8B 100
414937 R38698 Hs 12382 ESTs 100
419643 F06066 Hs 91791 chromosome 11 open reading frame 25 95
407173 T64349 gb yc10d08 s1 Stratagene lung (937210) H 95
412454 R55745 Hs 167330 ESTs 95
439366 AF100143 Hs 6540 fibroblast growth factor 13 94
415315 F12240 Hs 250655 prothymosin, alpha (gene sequence 28) 93
441790 AW294909 Hs 132208 ESTs 92
448117 H49129 Hs 172982 ESTs 9 1
400661 90
433558 AA833757 Hs 201769 ESTs. Weakly similar to T24435 hypothed 90
412453 R20205 Hs 167330 ESTs 90
408920 AL120071 Hs 48998 fibronecdn leucine πch transmembrane p 89
409031 AA376836 Hs 76728 ESTs 87
428106 BE620016 Hs 182470 PTD010 protein 83
446544 AI631932 Hs 7047 ESTs, Weakly similar to Unknown (H sapie 82
423479 NM.014326 Hs 129208 death-associated protein kinase 2 82
439480 AL038511 Hs 125316 ESTs, Weakly similar to S33990 finger pr 82
418036 Z37976 Hs 83337 latent transforming growth factor beta b 80
456490 U83171 Hs 97203 small inducible cytokine subfamily A (Cy 80
410200 AA082557 Hs 101915 Stargardt disease 3 (autosomal dominant) 80
414602 AW630088 Hs 76550 Homo sapiens mRNA, cONA DKFZp564B1264 (f 80
408428 NM 014787 Hs 44896 DnaJ (Hsp40) homolog, subfamily B, membe 79
437073 AI885608 Hs 94122 ESTs 79
408434 AW195317 Hs 107716 hypothetical protein FLJ22344 79
438150 AA037534 Hs 79059 transforming growth factor, beta recepto 79
440209 H05049 Hs 22269 neurexin 3 78
408119 W26213 Hs 101672 ESTs, Weakly similar to T00331 hypothed 78
417421 AL138201 Hs 82120 nuclear receptor subfamily 4, group A, m 78
410587 AA370706 Hs 86412 chromosome 9 open reading frame 5 78
429611 AI889077 Hs 211388 Homo sapiens BAC clone CTB-60N22 from 7q 77
405800 77
421750 AK000768 Hs 107872 hypothetical protein FLJ20761 77
426356 BE536836 Hs 98682 hypothedcal protein FKSG32 77
423440 R25234 Hs 143434 contacdn 1 77
445148 AI214510 Hs 146304 ESTs 76
416294 D86980 Hs 79170 KIAA0227 protein 76
424087 N69333 Hs 143434 contacdn 1 76
437479 R61866 Hs 101277 ESTs 75
405071 75
421224 AW402154 Hs 125812 ESTs 74
442025 AW887434 Hs 11810 CDA11 protein 74
459476 BE185844 gb IL5-HT0731-110500-087-c08 HT0731 Homo 72
430573 AA744550 Hs 136345 ESTs 7 1
401836 7 1
448958 AB020651 Hs 22653 KIAA0844 protein 7 1
430152 AB001325 Hs 234642 aquapoπn 3 7 1
419474 AW968619 Hs 155849 ESTs 7 1
401780 7 1
446052 AA358760 gb EST67699 Fetal lung II Homo sapiens c 70
423605 AF047826 Hs 129887 cadheπn 19, type 2 70
433098 AW190593 Hs 151143 ESTs 70
449511 AI436187 Hs 296261 guanine nudeodde binding protein (G pr 69
451285 AW137912 Hs 227583 Homo sapiens chromosome X map Xp11 23 L- 68
428414 AL049980 Hs 184216 DKFZP564C152 protein 68
419273 BE271180 Hs 293490 ESTs, Weakly similar to I38022 hypothed 68
443155 R54485 Hs 23772 ESTs 68
450561 R49674 Hs 25909 ESTs 68
433068 NM 006456 Hs 288215 sialyltransferase 68
440729 AA904739 Hs 128204 ESTs 68
448426 BE018315 Hs 280776 taπkyrase, TRF1-ιnteracdng ankynn-rela 67
423589 AA328082 Hs 209569 ESTs 66
415681 AI379882 Hs 72630 ESTs 65 413510 F13044 gb HSC3HH101 normalized infant brain cDN 64
427992 Y15014 Hs 181353 UDP-Gal betaGlcNAc beta 1,3-galactosyltr 64
453344 BE349075 Hs 44571 ESTs 64
450642 R39773 Hs 7130 copme IV 64
432251 AW972983 Hs 232165 polycythemia rubra vera 1, cell surface 64
429322 D86984 Hs 199243 KIAA0231 protein 64
444927 AW016637 Hs 199425 ESTs 64
447482 AB033059 Hs 18705 KIAA1233 protein 64
400332 S66407 Hs 248032 FLT4 63
440703 AL137663 Hs 7378 Homo sapiens mRNA, cDNA DKFZp434G227 (fr 63
446129 AW244073 Hs 145946 ESTs 63
454076 AW204712 Hs 61957 ESTs 63
425526 AA359933 gb EST69040 Fetal lung II Homo sapiens c 63
421913 AI934365 Hs 109439 osteoglycin (osteomducdve factor, mime 63
434273 AA913143 Hs 26303 ESTs 62
408480 AI350337 Hs 164568 fibroblast growth factor 7 (keradnocyte 62
451301 AI769514 Hs 209890 EST 62
430754 AW862610 Hs 157068 ESTs 62
438356 AA805530 Hs 48527 ESTs 62
422743 BE304678 Hs 119598 πbosomal protein L3 62
453355 AW295374 Hs 31412 Homo sapiens cDNA FU 11422 fis, clone HE 62
426388 AW081394 Hs 97103 ESTs 62
452502 AI904296 gb PM-BT046-220199-286.1 BT046 Homo sapi 6 1
402546 61
457534 AI761307 Hs 232226 ESTs 6 1
408165 AL137573 Hs 43143 Homo sapiens mRNA, cDNA DKFZp564A2463 (f 6 1
404958 6 1
432501 BE546532 Hs 25682 Homo sapiens mRNA for KIAA1863 protein, 6 1
442979 AW440782 Hs 174743 ESTs 6 1
422262 AL022315 Hs 113987 lecdn, galactoside-bindmg, soluble, 2 60
408713 NM 001248 Hs 47042 ectonucleoside tophosphate diphosphohyd 60
454065 BE394588 gb 601311808F1 NIH.MGC_44 Homo sapiens c 60
430004 U27768 Hs 227571 regulator of G-protem signalling 4 59
401521 59
425087 R62424 Hs 126059 ESTs 59
446298 AF187813 Hs 14637 kidney- and liver-specific gene 59
417761 R13727 Hs 21435 ESTs 59
424806 AA382523 Hs 105689 MSTP031 protein 59
441695 T12411 Hs 183745 hypothedcal protein FU 13456 59
457483 AB034694 Hs 272558 endomucιn-1 59
417175 R44558 Hs 94002 ESTs 58
437483 AL390174 gb Homo sapiens mRNA cDNA DKFZp547J184 58
436427 AI344378 Hs 143399 ESTs 58
411939 AI365585 Hs 146246 ESTs 58
459053 AI807052 Hs 210361 ESTs 57
411052 AW814950 gb MR1-ST0206-130400-023-d06 ST0206 Homo 57
431063 Z98949 Hs 326843 hypothetical protein bk125H2 1 57
450382 AA397658 Hs 60257 Homo sapiens cDNA FLJ13598 fis, clone PL 57
408478 NM 000806 Hs 45740 gamma-aminobutync acid (GABA) A recepto 57
442676 AI733585 Hs 130897 ESTs 57
446443 AV659082 Hs 134228 ESTs 57
400865 57
459080 AW192083 Hs 290855 ESTs 56
407952 AI215902 Hs 88845 ESTs, Highly similar to T50835 hypothed 56
431984 AL080239 Hs 272284 Human DNA sequence from clone GS1-256022 56
425705 AF007833 Hs 159265 kruppel-related zinc finger protein hcKr 56
442238 AW135374 Hs 270949 ESTs, Moderately similar to F41925 hypot 56
422994 AW891802 Hs 296276 ESTs 56
457148 AF091035 Hs 184627 KIAA0118 protein 56
428356 AL046991 Hs 10338 ESTs 56
415927 AL120168 Hs 78919 Kell blood group precursor (McLeod pheno 55
402092 55
440526 AI832243 Hs 211471 ESTs 55
444409 AI792140 Hs 49265 ESTs 55
417877 AI025829 Hs 86320 ESTs 54
458238 AW071521 Hs 333541 beta-amyloid binding protein precursor 54
430702 U56979 Hs 250651 H factor 1 (complement) 54
456189 H91010 Hs 44940 ESTs 54
427424 AA402453 Hs 113011 ESTs 54
437354 AA749215 Hs 291886 ESTs 54
455617 BE078070 gb CM1-BT0614-160300-149-f02 BT0614 Homo 54
429290 AF203032 Hs 198760 neurofilament, heavy polypepdde (200kD) 53
427861 AA813185 Hs 98183 ESTs 53
408556 U49516 Hs 46362 5-hydroxytryptamιne (serotonin) receptor 53
444209 AI753134 Hs 1 6494 ESTs 53
422831 R02504 Hs 332943 ESTs S 3
403180 53
418026 BE379727 Hs 83213 fatty acid binding protein 4, adipocyte 53
430339 W28608 Hs 239625 integral membrane protein 2B 52
431596 T34708 Hs 272927 Sec23 (S cerevisiae) homolog A 52
431930 AB035301 Hs 272211 cadhenn 7, type 2 52
437403 AI208149 Hs 121196 ESTs 52
438285 AA782845 Hs 22790 ESTs 52 439901 N73885 Hs 124169 ESTs 52
438507 AA809052 Hs 211275 ESTs 52
449222 AW293984 Hs 197621 ESTs 52
402834 AK001507 Hs 306084 Homo sapiens clone FLB6914 PR01821 mRNA, 52
419042 T81429 Hs 221065 ESTs 52
436777 AA731199 Hs 293130 ESTs 52
445071 AI280246 Hs 149504 ESTs 5 1
408016 AW136827 Hs 256096 ESTs 5 1
412047 AA934589 Hs 49696 ESTs 5 1
436953 AW959074 Hs 23648 Homo sapiens cDNA FU 13097 fis, clone NT 51
436773 AW078629 Hs 82110 PC4 and SFRS1 interacdng protein 1 5 1
409263 AA069573 Hs 50319 ESTs 51
453830 AA534296 Hs 20953 ESTs 5 1
459580 AA022888 Hs 176065 ESTs 51
417616 R07728 Hs 268668 ESTs 51
423457 F08208 Hs 283844 similar to rat tπcarboxylate camer-li 51
441535 AL135735 Hs 7885 phosphaddylmositol binding clathπn as 50
416490 AF090116 Hs 79348 regulator of G-protem signalling 7 50
417284 N62889 Hs 107242 Homo sapiens cDNA FU12965 fis, clone NT 50
447135 T58148 gb yb98g06 s1 Stratagene lung (937210) H 50
448605 AL109678 Hs 21597 Homo sapiens mRNA full length insert cDN 50
442240 AI791883 Hs 292719 ESTs 49
459399 BE407712 Hs 153998 creadne kinase, mitochondπal 1 (ubiqui 49
427972 AA864870 Hs 181304 putadve gene product 49
432944 AA570687 Hs 38512 ESTs 49
440198 BE560093 gb 601345159F1 NIH MGC 8 Homo sapiens cD 49
444047 AI097452 Hs 135095 ESTs 49
416040 AW819158 Hs 289044 Homo sapiens cDNA FU12048 fis, clone HE 49
444922 AI921750 Hs 144871 Homo sapiens cDNA FU13752 fis, clone PL 48
436670 AI690021 Hs 201536 ESTs 48
448072 AI459306 Hs 24908 ESTs 48
408936 AL138043 Hs 293549 ESTs 48
412622 AW664708 Hs 171959 ESTs 48
414943 D80647 Hs 124193 ESTs 48
429254 H10133 Hs 91846 hypothetical protein DKFZp761C121 48
453567 AI742835 Hs 33368 hypothetical protein FU11175 48
407906 AA369665 Hs 41185 Homo sapiens mRNA, cDNA DKFZp56401262 (f 48
441028 AI333660 Hs 17558 Homo sapiens cDNA FU14446 fis, clone HE 47
405130 47
455225 AW996689 gb QV3-BN0046-150400-151-g09 BN0046 Homo 47
446218 AV657159 gb AV657159 GLC Homo sapiens cDNA ctone 47
443347 AI052543 Hs 133244 melanoma-denved leucine zipper, extra-n 47
402176 47
416577 BE063207 Hs 79381 grancalcin 47
436221 AK001781 Hs 296543 Homo sapiens cDNA FU10919 fis, clone OV 47
420480 AL137361 Hs 98173 hypothetical protein 47
400800 Y10262 Hs 46925 eyes absent (Drosophila) homolog 3 46
435161 AF124150 Hs 272091 ESTs 46
404793 46
430895 U66581 Hs 248121 G protein-coupled receptor 22 46
438571 AW020775 Hs 56022 ESTs 46
445924 AI264671 Hs 164166 ESTs 46
444585 AW170015 Hs 6594 ESTs 46
421044 AF061871 Hs 311736 Human DNA sequence from clone RP1-238D15 46
418274 AI458587 Hs 128677 Human DNA sequence from clone RP1-50O24 46
425475 W56339 Hs 107057 ESTs 46
434311 BE543469 Hs 266263 Homo sapiens cDNA FU14115 fis, clone MA 45
414272 AI651603 Hs 46988 ESTs 45
445235 AI564022 Hs 138207 ESTs 45
414327 BE408145 Hs 185254 ESTs, Weakly similar to T24435 hypothed 45
414630 BE410857 gb 601301177F1 NIH.MGC.21 Homo sapiens c 45
414456 H74314 gb yu56e10 r1 Soares fetal liver spleen 45
401024 45
414699 AI815523 Hs 76930 synuclem, alpha (non A4 component of am 45
423449 AI497900 Hs 33067 ESTs 45
405138 45
413544 BE147225 gb PM2-HT0225-031299-003-f 11 HT0225 Homo 45
453880 AI803166 Hs 28462 ESTs, Weakly similar to I38022 hypothed 45
433521 T66087 Hs 112482 Homo sapiens unknown mRNA sequence 44
441184 AA922009 Hs 150269 ESTs 44
429876 AB028977 Hs 225974 KIAA1054 protein 44
445481 AW661846 Hs 148836 ESTs 44
452340 NM.002202 Hs 505 ISL1 transcnpdon factor, LIM/homeodoma 44
404769 44
444331 AW193342 Hs 24144 ESTs 44
429726 AW628326 Hs 27151 ESTs 44
449093 AB035356 Hs 22998 neurexin 1 44
451959 AA056203 Hs 27337 hypothedcal protein FU20623 44
415716 N59294 Hs 179662 nucleosome assembly protein 1-lιke 1 44
417888 R23053 gb yh31a05 r1 Soares placenta Nb2HP Homo 44
419656 AB002314 Hs 92025 KIAA0316 gene product 44
425864 U56420 Hs 159903 olfactory receptor, family 5, subfamily 44
435078 AW518888 Hs 40937 ESTs 44 413493 BE144444 gb MR0-HT0168-141199-002-f09 HT0168 Homo 43
432712 AB016247 Hs 288031 sterol-C5-desaturase (fungal ERG3, delta 43
459650 R25754 Hs 301185 ESTs 43
404828 43
423782 AI472209 Hs 323117 ESTs 43
426867 AA460967 Hs 22668 ESTs 43
426802 AA385182 Hs 46699 ESTs 43
457353 X65633 Hs 248144 melanocortin 2 receptor (adrenocorticotr 43
412112 BE180342 gb RC3-HT0622-130400-012-a07 HT0622 Homo 43
401522 N47812 Hs 306198 CGI-35 protein 43
419055 AI365384 Hs 11571 Homo sapiens cDNA FU11570 fis, clone HE 43
410171 H07892 Hs 12431 ESTs 43
419564 U08989 Hs 91139 solute earner family 1 (neuronal/epithe 43
458789 AL157468 Hs 325825 Homo sapiens cDNA FU20848 fis, clone AD 43
455040 AW852286 gb QVO-CT0225-100400-187-d08 CT0225 Homo 43
438533 AI440266 Hs 170673 ESTs, Weakly similar to T24832 hypothed 43
459005 AA447679 Hs 144558 ESTs, Weakly similar to ALU1.HUMAN ALU S 42
418489 U76421 Hs 85302 adenosine deaminase, RNA-specific, B1 (h 42
433389 AF038171 gb Homo sapiens clone 23671 mRNA sequenc 42
454356 AW390363 Hs 11522 hypothedcal protein from Xq28 42
442339 BE299668 Hs 227591 ESTs, Weakly similar to 1901303A Leu zιp 42
421249 AA285362 gb HTH277 HTCDL1 Homo sapiens cDNA 5'0 42
443998 AI620661 Hs 296276 ESTs 42
452197 AW023595 Hs 232048 ESTs 42
451117 AA015752 Hs 205173 ESTs 42
404501 AW247252 Hs 75514 nucleoside phosphorylase 42
410378 R23324 Hs 41693 DnaJ (Hsp40) homolog, subfamily B, membe 42
422528 AB011182 Hs 118087 KIAA0610 protein 42
440323 AA970614 Hs 127992 ESTs 4 1
425767 AF054176 Hs 159483 chromosome 1 open reading frame 7 4 1
434460 AA478486 Hs 3852 KIAA0368 protein 41
410362 H04811 Hs 93164 proprotein convertase subdlisin/kexm t 4 1
413121 T96090 Hs 142678 ESTs 41
409403 AA668224 Hs 6634 Homo sapiens cDNA FU22547 fis, clone H 4 1
450235 AA007512 Hs 17538 ESTs 4 1
449754 H00820 Hs 30977 ESTs, Weakly similar to B34087 hypothed 41
421813 BE048255 gb tz49b05 y1 NCI CGAP Bm52 Homo sapien 4 1
408496 AI683802 Hs 136182 ESTs 4 1
430261 AA305127 Hs 237225 hypothedcal protein HT023 4 1
434101 AA625205 Hs 259599 KIAA1622 protein 4 1
451837 T92157 Hs 16970 ESTs 4 1
411772 BE170301 gb QV4-HT0536-040500-193-f05 HT0536 Homo 41
437630 AI252782 Hs 153026 SWAP-70 protein 4 1
430212 AA469153 gb nc67(04s1 NCI.CGAP.Pr1 Homo sapiens 40
400216 40
429830 AI537278 Hs 225841 DKFZP434D193 protein 40
453165 S74727 Hs 32042 aspartoacylase (ammoacylase 2, Canavan 40
418047 R37633 Hs 4847 ESTs 40
405354 40
427931 AW206512 Hs 186996 ESTs 40
428775 AA434579 Hs 143691 ESTs 40
449422 AA001373 Hs 59821 ESTs 40
453864 AW021407 Hs 21068 hypothedcal protein 40
456407 AW968614 gb EST380690 MAGE resequences, MAGJ Homo 40
441869 NM 003947 Hs 8004 hundngdn-associated protein inter actin 40
420784 T65158 Hs 102399 ESTs, Moderately similar to S65657 alpha 40
425195 AA352026 Hs 94319 VPS10 domain receptor protein 40
429628 H09604 Hs 13268 ESTs 40
410087 F12079 Hs 332579 ESTs 40
409840 AW502122 gb UI-HF-BROp-aιr-c-08-O-UI r1 NIH.MGC.5 40
452854 AA437061 Hs 14060 prokinedcin 1 precursor 40
419910 AA662913 Hs 190173 ESTs, Weakly similar to A46010 X-lmked 40
427443 AA402713 Hs 97872 ESTs 40
414990 C17758 Hs 221652 Homo sapiens cDNA FU 14323 fis, clone PL 39
412678 AA115575 Hs 114914 ESTs 39
405629 39
420299 AI056871 Hs 15276 ESTs 39
453098 Z25935 Hs 86379 ESTs 39
435752 AF230801 gb Homo sapiens growth hormone receptor 39
441005 Z41305 Hs 303172 Homo sapiens mRNA, cDNA DKFZp547G133 (fr 39
414516 AI307802 Hs 135560 ESTs, Weakly similar to T43458 hypothed 39
442257 AW503831 Hs 323370 Human EST clone 25267 manner transposon 39
422563 BE299342 Hs 19348 hypothedcal protein FU13119 39
406697 M21388 Hs 123017 Human unproducdvely rearranged lg mu-ch 39
443850 AW014723 Hs 334612 ESTs 39
412677 AW029608 Hs 17384 ESTs 39
422788 AL117352 Hs 120828 Human DNA sequence from clone RP5-876B10 39
405377 39
414376 BE393856 Hs 66915 ESTs, Weakly similar to 167Kd protein [ 39
453341 AI758912 Hs 296341 adenylyl cycl3se-assocιated protein 2 39
431960 AW241821 Hs 301927 c61A 39
416854 H40164 Hs 80296 Purkinje cell protein 4 39
427264 AA400117 Hs 125747 ESTs 39 422746 NM 004484 Hs 119651 glypican 3 39
452346 BE243534 gb TCBAP1D0885 Pediatnc pre-B cell acut 39
414666 NM 004466 Hs 76828 glypican 5 38
418217 AI910647 Hs 13442 ESTs 38
419118 AA234223 Hs 139204 ESTs 38
445017 AI205493 Hs 176860 ESTs 38
405867 38
422760 BE409561 gb 601299865F1 NIH_MGC_21 Homo sapiens c 38
453863 X02544 Hs 572 orasomucoid 1 38
457821 H47166 Hs 124322 ESTs, Weakly similar to A47582 B-cell gr 38
457330 AB013818 Hs 247220 peroxisome biogenesis factor 10 38
435600 AL047034 Hs 119747 ESTs 38
456083 U46922 Hs 77252 fragile histidine toad gene 38
413341 H78472 Hs 191325 ESTs, Weakly similar to T18967 hypothed 38
449057 AB037784 Hs 22941 KIAA1363 protein 38
421855 F06504 Hs 27384 ESTs, Moderately similar to ALU4 HUMA A 38
414764 AW013887 Hs 72047 ESTs 38
404391 37
433629 R13140 Hs 13359 ESTs 37
424738 AI963740 Hs 46826 ESTs 37
401315 37
407706 AA191085 Hs 26612 ESTs, Moderately similar to S23650 retro 37
440530 AA888646 Hs 174187 ESTs 37
433930 AA620338 Hs 273781 ESTs 37
409662 AW452320 Hs 279726 ESTs 37
437268 AI754847 Hs 227571 regulator of G-protem signalling 4 37
445688 AI248205 Hs 153244 ESTs 37
408593 R19566 Hs 197617 ESTs 37
417091 AA193283 Hs 291990 ESTs 37
448556 AW885606 Hs 5064 ESTs 37
423135 N67655 Hs 26411 ESTs 37
400135 37
459150 BE155356 gb PM1-HT0350-160300-009-d06 HT0350 Homo 37
457221 AW383197 Hs 218260 ESTs 37
451660 AI807927 Hs 249601 ESTs 37
401600 BE247275 Hs 151787 U5 sπRNP-specific protein, 116 kD 37
446818 AI342668 Hs 279765 ESTs 37
447795 AW295151 Hs 163612 ESTs 37
427562 R56424 Hs 26534 ESTs 36
412258 AA376768 Hs 324841 hypothedcal protein FU22622 36
454339 AW381980 gb QV4-HT0316-091199-028-d05 HT0316 Homo 36
439274 AF086092 Hs 48372 ESTs 36
452381 H23329 Hs 290880 ESTs, Weakly similar to ALU1 HUMAN ALU S 36
422897 AA679784 Hs 4290 ESTs 36
429656 X05608 Hs 211584 neurofilament light polypepdde (68kD) 36
421908 AW935200 Hs 285814 sprouty (Drosophila) homolog 4 36
407978 AW385129 Hs 41717 phosphodiesterase 1A, calmodulin-depende 36
426452 AW614271 Hs 121647 ESTs, Highly similar to AC0060148 Simil 36
400685 36
417154 AI674701 Hs 21388 ESTs 36
447176 Z42549 Hs 160893 ESTs 36
423893 AL031709 Hs 134846 Human DNA sequence from clone 316G12 on 36
449231 BE410360 Hs 298573 KIAA1720 protein 36
411607 AW853498 gb RC1-CT0252-170200-025-h02 CT0252 Homo 36
405977 36
441470 BE503874 Hs 301986 ESTs 36
423568 NM.O05256 Hs 129818 growth arrest-specific 2 36
441235 AI884586 Hs 135570 Homo sapiens cDNA FU21268 fis, clone C 36
450236 AW162998 Hs 24684 KIAA1376 protein 36
425364 AF052150 Hs 155959 Homo sapiens clone 24533 mRNA sequence 36
426775 AA384564 Hs 108829 ESTs 36
414831 M31158 Hs 77439 protein kinase, cAMP-dependent, regulate 36
416876 AW501916 Hs 117897 ESTs 36
400878 36
425153 AW023193 Hs 27046 ESTs 36
432222 AI204995 gb an03c03 x1 Stratagene schizo brain S1 35
415047 F13142 gb HSC3JD031 normalized infant brain cDN 35
401532 35
446495 D60923 Hs 153460 ESTs 35
431325 AW026751 Hs 5794 ESTs, Weakly similar to 2109260A B cell 35
445898 AF070623 Hs 13423 Homo sapiens clone 24468 mRNA sequence 35
455901 BE155527 gb PM1-HT0350-19040C-013-b08 HT0350 Homo 35
416421 AA134006 Hs 79306 eukaiyodc translation initiation factor 35
455697 BE067952 gb CM0-BT0365-061299-122-g09 BT0365 Homo 35
405678 35
418207 C14685 Hs 34772 ESTs 35
425383 D83407 Hs 156007 Down syndrome cndcal region gene 1-lιk 35
417027 AA192306 Hs 23926 tπadm 35
408367 AK001178 Hs 44424 homolog of rat orphan transporter v7-3 35
417702 R09935 Hs 191146 ESTs 35
445687 W80382 Hs 149297 ESTs 35
408776 AA057365 Hs 63356 ESTs, Weakly similar to I38022 hypothed 35
413164 BE068494 gb MR1 -BT0371-050500-009-312 BT0371 Homo 35 414593 BE386764 gb 601273249F1 NIH_MGC_20 Homo sapiens c 35
453220 AB033089 Hs 32452 Homo sapiens mRNA for KIAA1263 protein, 35
415621 AI648602 Hs 55468 ESTs 35
454437 AI248173 Hs 191460 hypothedcal protein MGC12936 35
446066 AI343931 Hs 149383 ESTs 35
423374 AB037770 Hs 127656 KIAA1349 protein 35
419347 C15944 Hs 90005 supeπorcervical ganglia, neural specifi 35
418516 NM 006218 Hs 85701 phosphoιnosιtιde-3-kιnase, catalydc, al 35
451776 W45679 Hs 169854 hypothedcal protein SP192 35
432305 M62402 Hs 274313 insulin like growth factor binding prote 35
456995 T89832 Hs 170278 ESTs 35
403323 35
425022 M95724 Hs 154207 centromere protein C 1 35
439394 AA149250 Hs 56105 ESTs 34
433803 AI823593 Hs 27688 ESTs 34
450715 AI266484 Hs 31570 ESTs, Weakly similar to KIAA1324 protein 34
411474 AW848427 gb IL3-CT0214-150200-075-H10 CT0214 Homo 34
415076 NM 000857 Hs 77890 guanylate cyclase 1, soluble, beta 3 34
423826 U20325 Hs 1707 cocaine- and amphetamine-regulated trans 34
459495 BE544158 gb 601076707F1 NIH MGC 12 Homo sapiens c 34
427173 BE255017 Hs 97540 ESTs 34
408112 AW451982 Hs 248613 ESTs 34
446092 N33522 Hs 145894 ESTs 34
416868 AI656856 Hs 292597 ESTs 34
458234 BE551408 Hs 127196 ESTs 34
419555 AA244416 gb nc07 11 s1 NCI.CGAP Prl Homo sapiens 34
414314 BE312991 gb 601150275F1 NIH_MGC_19 Homo sapiens c 34
400425 AY0O4252 Hs 287385 PR domain containing 12 34
414366 BE549143 gb 601076456F1 IH MGC 12 Homo sapiens c 34
434053 AW445136 Hs 134946 ESTs 34
449997 AI683052 Hs 201577 KIAA1829 protein 34
433461 AI636047 Hs 197623 ESTs 34
428006 AA418743 Hs 98306 KIAA1862 protein 34
424695 U58331 Hs 151899 sarcoglycan, delta (35kD dystrophiπ asso 34
443294 AI733625 Hs 133053 ESTs 34
428212 AW444451 Hs 134812 ESTs 34
457673 AA551569 Hs 272034 hypothetical protein PR02822 34
446390 AA233393 Hs 14992 hypothedcal protein FU11151 33
428536 AI143139 Hs 2288 visinm-like 1 33
426597 AA382250 Hs 145601 ESTs 33
410366 AI267589 Hs 302689 hypothedcal protein 33
458258 AW406546 Hs 127971 ESTs 33
401738 33
409038 T97490 Hs 50002 small inducible cytokine subfamily A (Cy 33
425785 T27017 Hs 159528 Homo sapiens clone 24400 mRNA sequence 33
433328 AW298159 Hs 23644 ESTs, Weakly similar to S65824 reverse t 33
414541 BE293116 Hs 76392 aldehyde dehydrogenase 1 family, member 33
434998 AW975157 Hs 26037 ESTs 33
456359 AI967991 Hs 93574 homeo box D3 33
426527 NM 001037 Hs 170238 sodium channel, voltage-gated, type I. b 33
454267 AA437199 Hs 656 cell division cycle 25C 33
400302 N48056 Hs 1915 folate hydrolase (prostate-specific memb 33
434077 AF116659 Hs 321151 Homo sapiens PR01412 mRNA, complete eds 33
436602 AI793222 Hs 166817 ESTs 33
449204 AB000099 Hs 23251 Down syndrome cndcal region gene 4 33
417935 R53697 Hs 170044 ESTs 33
423310 AA325225 Hs 124023 Homo sapiens cDNA FLJ14218 (is clone NT 33
436624 T64297 Hs 5241 fatty acid binding protein 1, liver 33
453406 AI192987 Hs 61784 hypothetical protein FU14451 33
420164 AW339037 Hs 24908 ESTs 33
447826 AW779317 Hs 258556 ESTs 33
419875 AA853410 Hs 93557 proenkephal 33
444612 AW138111 Hs 22902 ESTs 33
418504 BE159718 Hs 85335 Homo sapiens mRNA, cDNA DKFZp564D1462 (f 32
415242 R45986 Hs 295014 ESTs 32
418188 AW139413 Hs 151880 ESTs 32
430355 NM 006219 Hs 239818 phosphoιnosιdde-3-kιnase, catalydc, be 32
421640 AW966652 gb EST378726 MAGE resequences, MAGI Homo 32
432359 AA076049 Hs 274415 Homo sapiens cDNA FU10229 fis, clone HE 32
408806 AW847814 Hs 289005 Homo sapiens cDNA FU21532 fis, clone C 32
400409 AF153341 Hs 283954 Homo sapiens winged helix/forWiead trans 32
446015 T30968 Hs 13531 hypothetical protein FLJ10971 32
425495 AA358454 Hs 78026 ESTs, Weakly similar to similar to ankyr 32
403092 32
452971 AI873878 Hs 91789 ESTs 32
454186 BE141030 gb MR0-HT0067-201099-002-h11 HT0067 Homo 32
401485 32
401949 32
457452 AW972675 gb EST384766 MAGE resequences, MAGL Homo 32
454100 AI693231 Hs 126043 chromosome 21 open reading frame 51 32
448440 AA173467 Hs 62402 p21/Cdc42/Rac1-actιvated kinase 1 (yeast 32
421200 AA284811 Hs 264433 ESTs 32
430142 NM.000437 Hs 234392 platelet-acdvadng factor acetylhydrola 32 433197 AB040889 Hs 281022 KIAA1456 protein 32
443509 AV645470 gb AV645470 GLC Homo sapiens cDNA clone 32
440827 AI733110 Hs 128128 ESTs 32
432799 NM 016161 Hs 278960 alpha-1 ,4-N-acetylglucosammyltransferas 32
409257 AW370362 gb RC1-BT0255-181099-012-d07 BT0255 Homo 32
459235 BE246010 Hs 271468 Homo sapiens mRNA for FLJ00038 protein, 32
416789 AA223439 Hs 79933 cydm l 32
429809 AL162010 Hs 223603 Homo sapiens mRNA, cDNA DKFZp761D09121 ( 32
420156 AW449258 Hs 6187 ESTs 32
455577 BE006341 gb RC2-BN0127-240300-011-b05 BN0127 Homo 32
400617 AF151064 Hs 36069 hypothetical protein 32
437129 AL049327 Hs 302057 Homo sapiens mRNA, cDNA DKFZp564E016 (fr 32
451820 AW058357 Hs 337353 ESTs 32
457535 AA609685 Hs 278672 membrane component chromosome 11 , surfa 32
419956 AL137939 Hs 40096 ESTs 3 1
456235 AA203637 gb zx58b12 r1 Soares fetal liver spleen 3 1
423930 AA332697 Hs 42721 ESTs 3 1
403796 31
414085 AA114016 Hs 75746 aldehyde dehydrogenase 1 family, member 31
445886 AI793176 Hs 145596 ESTs 3 1
414401 AI760159 Hs 124833 ESTs 31
441573 BE563966 Hs 6529 ESTs, Weakly similar to 178885 senne/th 3 1
450725 R71389 Hs 175951 ESTs 3 1
458805 AI282933 Hs 23294 hypothedcal protein FU 14393 31
417868 AI078534 Hs 122592 ESTs 3 1
458391 AI792628 Hs 133273 ESTs 31
423346 AI267677 Hs 127416 synaptoianin 1 31
454486 AW857077 gb RC1-CT0302-140300-016-f04 CT0302 Homo 3 1
408341 AW182952 Hs 249957 ESTs 3 1
410669 AW805749 Hs 318885 superoxide dismutase 2, mi.ochondn.-l 3 1
404907 31
434910 AI333863 Hs 215474 ESTs, Moderately similar to alternative! 31
436990 AI149729 Hs 120557 ESTs 31
441921 AI733376 Hs 164478 hypothedcal protein FU21939 similar to 3 1
454673 AW812807 gb RC3-ST0186-070100-016-C04 ST0186 Homo 3 1
429470 AI878901 Hs 203862 guanine nudeodde binding protein (G pr 3 1
404345 AA730407 Hs 159156 protocadhenn 11 3 1
408217 AI433201 Hs 279860 tumor protein, transladonally-coπtrolle 3 1
417313 AA195602 gb zr32f09 r1 Soares.NhHMPu.S1 Homo sapi 31
427322 AK0O2017 Hs 176227 hypothetical protein FU11155 31
411003 AA181018 Hs 13056 hypothetical protein FU 13920 3 1
425339 AA936330 Hs 198113 ESTs 3 1
426716 NM_006379 Hs 171921 sema domain, immunoglobulin domain (lg) 31
449078 AK001256 Hs 22975 KIAA1576 protein 3 1
429608 U49250 Hs 210862 T-box, brain, 1 3 1
442308 AA989402 Hs 111 fibroblast growth factor 9 (glia-acdvat 3 1
428465 AW970976 Hs 293653 ESTs 31
411666 AF106564 Hs 1346 neurofilament 3 (150kD medium) 3 1
447965 AW292577 Hs 94445 ESTs 31
413918 AW015898 Hs 71245 ESTs 3 1
419682 H13139 Hs 92282 paired-like homeodomain transcnpdon fa 3 1
425810 AI923627 Hs 31903 ESTs 31
427865 AA416931 Hs 126065 ESTs 31
429060 AW139155 Hs 194995 hypothedcal protein DKFZp434O0320 3 1
430708 U78308 Hs 278485 oifactoiy receptor, family 1, subfamily 31
448084 AI467800 Hs 271000 ESTs, Weakly similar to I38022 hypothed 31
454506 AW847346 gb RCO-CT0205-240999-021-e01 CT0205 Homo 3 1
414629 AA345824 Hs 76688 carboxylesterase 1 (monocyte/macrophage 30
422963 M79141 Hs 13234 ESTs 30
417696 BE241624 Hs 82401 CD69 antigen (p60, eariy T-cell acdvad 30
448175 BE296174 Hs 225160 hypothedcal protein FU13102 30
414686 BE409757 Hs 23189 ESTs, Moderately similar to TBB2 HUMAN T 30
458360 AI027207 Hs 132253 ESTs 30
451829 AW964081 Hs 247377 ESTs 30
445179 AI949743 Hs 224768 ESTs 30
433090 AI720050 Hs 145362 immortalization-upregulated protein 30
432018 AA524447 Hs 152377 ESTs 30
407988 N47760 Hs 285107 hypothedcal protein FU 13397 30
405911 30
418808 AI821836 Hs 10359 ESTs 30
431900 AW972048 Hs 192534 ESTs 30
452893 H18017 Hs 22869 ESTs, Moderately similar to KIAA1395 pro 30
423952 AW877787 Hs 136102 KIAA0853 protein 30
412000 AW576555 Hs 15780 ATP-bindmg cassette sub-family A (ABC1 30
405793 30
410711 AB002316 Hs 65746 KIAA0318 protein 30
411279 AW884776 gb QV4-OT0067-010300-121-d01 OT0067 Homo 30
423957 AW978309 Hs 136235 Homo sapiens cDNA FU13542 fis, clone PL 30
427071 AA397958 Hs 192719 ESTs 30
434961 AW974956 gb EST387061 MAGE resequences MAGN Homo 30
TABLE 26B
Pkey Unique Eos probeset idendfier number CAT number Gene cluster number Accession Genbank accession numbers
Pkey CAT Number Accession
409257 1112994.1 AW370362 AW809101
409840 1156071 1 AW502122 AW502125 AW501663 AW501720
411052 1230374 1 AW814950 R98513 H69459 BE176242 H54583
411279 1237516 1 AW884776 AW935737 AW835261 AW835247 AW835246 AW835263 AW835240 AW835258
411474 1247047.2 AW848427 AW848890 AW848159 AW848118 AW848634 AW848285 AW848086 AW848485 AW848283 AW848162
411607 1251251 1 AW853498 AW853442 AW853590 AW853433 AW853592
411772 1257386 1 BE170301 AW861539 AW904851 BE154336 BE154090 BE154275
412112 1277883 1 BE180342 BE180347 AW901900 BE180222 BE180218 BE180226 BE180413 BE180416 AW901899 BE180228 AW901897 BE180224 AW901898
BE180223 BE180219 BE180346 BE180343 BE180418 BE180225 BE180221 BE180341 AW901894 BE180217 BE180227 AW901891 BE180345
AW893614 AW893615 H85799 H83501 BE180220
413164 1351422.1 BE068494 BE068414 BE068332 BE068347 BE068706 BE068623 BE068450 BE068480 BE068350 BE068295 BE068498 BE068765 BE068328
BE068778 BE068671 BE068526 BE068493 BE068433 BE068740 BE068306 BE068631 BE068580 BE068445 BE068567 BE068521 BE068549
BE068392 BE068307 BE068692 BE068473 BE068754 BE068476 BE068685 BE068626 BE068591 BE068745 BE068434 BE068759 BE068628
BE068723 BE068529 BE068689 BE068383 BE068422 BE068470 BE068522 BE068618 BE068354 BE068748 BE068683 BE068303 BE068602
BE068739 BE068374 BE068302 BE068625 BE068596 BE068663 BE068429 BE068605 BE068693 BE068672 BE068401 BE068579 BE068329
BE06839O BE068419 BE068393 BE068447 BE068675 BE068311 BE068540 BE068301 BE068543 BE0687198E068369 BE068324 BE068588
BE068568 BE068317 BE068384 BE068547 BE068674 BE068436 BE068321 BE068361 BE068676 BE068499 BE068299 BE068352 BE068410
BE068293 BE068418 BE068552 BE068598 BE068327 BE068550 BE068712 BE068661 BE068733 BE068525 BE068752 BE068357 BE068330
BE068565 BE068538 BE068340 BE068537 BE068761 BE068632 BE068758
413493 1373555 1 BE144444 BE144430 413510 1374377.1 F13044 T77009 BE145525 BE145493 413544 1375671.1 BE147225 BE147205 BE147234 414220 1426940.1 BE298094 BE267860 414314 1435028.1 BE312991 8E272945 414366 1438636.1 BE549143 BE390613 BE277344 414456 1447655.1 H74314 BE299593 414593 1464909.1 BE386764 BE387560 414630 1468083.1 BE410857 BE390605 415047 1517450.1 F13142 Z42926 F06135 F06147 H08517 D51360 T75341 417313 166644.1 AA195602 W01148 N40632 417888 1706092.1 R23053 R79884 R76271 419555 185884.1 AA244416 AA244401 421249 200649.1 AA285362 AW752386 AW847156 AA285373 AW879575 AW879558 421640 204833.1 AW966652 AW966653 AA294989 AA385977 421813 207654.1 BE048255 AA313083 AA298419 422760 221034 1 BE409561 BE 162756 AW732798 425526 252776.1 AA359933 AA358889 AW955306 AW962995 AW837746 AW837755 AW837697 430212 314437 1 AA469153 AI718503 AA469225 432222 343347.1 AI204995 AW827539 AW969908 AW440776 AA528756 433389 36497.1 AF038171 Z43209 F07347 434961 396357.1 AW974956 AA781075 AA654944 435752 41050.1 AF230801 AF230800AA401795 AA398260 437483 43756.1 AL390174 AW898817 440198 48824.-2 BE560093 443509 57199.1 AV645470 T84636 T82805 446052 65988 1 AA358760 AA158850 AW062737 AW062738 AV656291 446218 66686.1 AV657159 BE145509 BE145512 BE145505 BE145507 447135 70963.1 T58148 AW516579 AW059603 452346 912206.1 BE243534 BE243752 A1880228 L44326 452502 919733 1 AI904296 BE007223 R30687 454065 998401.1 BE394588 AW024754 BE183166 BE183167 454186 1049791.1 BE141030 BE141474 BE141467 BE141753 BE141024 BE141761 AW177583 AW177579 AW177582AW177585 AW177587 AW807582 AW177581
BE141477 BE141520 BE141456 BE141492 BE141028 BE141775 BE141489 BE141751 AW177599 BE141750 AW177597 BE141512 BE141460
BE141749 AW177598
454339 1122972.1 AW381980 BE152244 BE152235 BE152238 BE152232 454486 1215703 1 AW857077 AW861268 AW847383 AW795787 454506 1219857.1 AW847346 AW847395 AW847408 AW847385 AW847342 AW847396 AW847339 AW801718 AW801787 454673 1228669.1 AW812807 AW812815 AW812802 455040 1250028.1 AW852286 AW851934 AW852096 AW852274 455225 1262318.1 AW996689 AW996380 AW996453 BE085650 AW868687 BE085595 455577 1333898.1 BE006341 BE006307 BE006311 455617 1346117.1 BE078070 BE061030 BE077927 455697 1351148 1 BE067952 BE067945 BE067942 BE067943 BE067949 BE067954 BE067944 BE067953 BE067956 BE067946 455901 1381569.1 BE155527 BE155503 BE155188 BE155126 456235 168686.1 AA203637 AA832266 H67452 456407 184986.1 AW96861 AA243209 AA281411 457452 339381.1 AW972675 AA541366 AA523039 459150 919196 1 BE155356 BE153488 BE153461 BE155059 BE155210 BE155413 BE153577 BE153688 BE155063 BE155347 AI903640 BE155492
TABLE 26C
Pkey t Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers 'Dunham, et al " refers to the publication entitled 'The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand I Indicates DNA strand from which exons were predicted Nt_posιdon I Indicates nudeodde posidons of predicted exons
Pkey Ref Strand Nt_posidon
400661 8118474 Plus 84912-85187
400685 8118768 Minus 72969-73050,73713-73800 400865 1945037 Minus 44482-45526
400878 9864757 Plus 31493-32842
401024 8117489 Plus 60551-60802
401315 9212516 Minus 198960-199619
401485 7341723 Plus 68009-68209,68841-69077
401521 7705251 Plus 9127-9234
401532 7798785 Plus 124414 124950,125050-125418
401738 2982169 Minus 41547-41757
401780 7249190 Minus 28397-28617,28920-2904529135-29296,29411-29567,29705-29787,30224-30573
401836 7534063 Plus 71981-72084
401949 3492889 Plus 160728-161660
402092 7249154 Minus 107533-108094
402176 7543687 Minus 10-750
402546 7637348 Plus 24673-25170
403092 8954241 Plus 174720-175016,175104-175406,175508-175813
403180 7523976 Minus 63603-63759
403323 8348082 Minus 120366-120845
403796 8099896 Minus 75073-77664
404391 3135305 Minus 26030-26173,27852-27997
404769 8099713 Minus 175801-176823
404793 7232206 Minus 61087-61590
404828 6580415 Minus 26291-27253
404907 7331453 Minus 102880-103828
404958 7407941 Minus 2731-4531
405071 7708797 Minus 11115-11552
405130 8516045 Plus 150235-150449
405138 8576241 Plus 90303-90516
405354 2642452 Plus 62213-53089
405377 5649375 Plus 216656-216848
405629 4508116 Minus 101678-101866
405678 4079670 Plus 151821-152027
405793 1405887 Minus 89197-89453
405800 2791346 Plus 19271 19813
405867 6758731 Minus 74553-75173
405911 6758795 Plus 101008-101643
405977 8247789 Minus 135548-136177
TABLE 27A ABOUT 533 CNS-ENRICHED GENES SIGNIFICANTLY DOWN-REGULATED IN GLIOBLASTOMA COMPARED TO NORMAL ADULT CNS TISSUES
Table 27A lists about 533 CNS-ennched genes significanUy down-regulated in glioblastoma compared to normal adult CNS dssues These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the rado of "average" noπnal CNS to "average" glioblastoma was greater than or equal to 2 The "average" normal CNS level was set to the 75* percendle amongst vanous normal CNS dssues The "average* glioblastoma level was set to the 85* percendle amongst vaπous tumor samples To enπch for CNS specific genes, the ratio of "average* CNS to "average" non-CNS normal adult tissues wβs calculated to be greater than or equal to 2 The "average" CNS level was set to the 85* percendle amongst vaπous CNS dssues The "average" normal non-CNS adult dssue level was set to the 85* percendle amongst vaπous non-CNS normal dssues In order to remove gene-specific background levels of non specific hybndization, the 10* percendle value amongst vanous non-malignant tissues was subtracted from both the numerator and the denominator before the rados were evaluated
Pkey Unique Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dtle
R1 Ratio of 75* percendle normal central nervous system tissue to 85* percendle tumor
R2 Ratio of 85* percendle central nervous system tissue to 85* percendle normal body dssue
Pkey ExAccn UnigenelD Unigene Title R1 R2
417275 X63578 Hs 295449 parvalbumin 290 300
430829 AW451999 Hs 194024 ESTs 257 62
410657 AF063228 Hs 65248 dynem, cytoplasmic, intermediate polype 226 258
419954 014720 Hs 93883 myelin protein zero (Charcot-Maπe-Tooth 21 2 303
416133 NM 001683 Hs 89512 ATPase Ca** transporting, plasma membra 155 168
416018 AW138239 Hs 78977 proprotein coπvertase subdlisin/kexin t 15 2 180
417167 AW206437 Hs 4290 ESTs 148 177
433940 H05129 Hs 7459 cyclic AMP-regulated phosphoprotein, 21 134 18 1
413324 V00571 Hs 75294 corticotropin releasing hormone 131 180
439830 AA846666 Hs 151489 ESTs, Weakly similar to XE7 HUMAN PROTEI 126 16 5
408068 AW148652 Hs 167398 ESTs 126 169
429096 AB011106 Hs 196012 KIAA0534 protem 122 21 1
412638 AA910199 Hs 203838 ESTs 122 160
442593 R39804 Hs 31961 ESTs 108 150
446353 AI290919 Hs 153661 ESTs 104 132
426365 AA376667 Hs 10283 RNA binding modf protein 8B 100 59
414937 R38698 Hs 12382 ESTs 100 108
419643 F06066 Hs 91791 chromosome 11 open reading frame 25 95 109
412454 R55745 Hs 167330 ESTs 95 14 1
439366 AF100143 Hs 6540 fibroblast growth factor 13 94 123
441790 AW294909 Hs 132208 ESTs 92 32
448117 H49129 Hs 172982 ESTs 9 1 128
433558 AA833757 Hs 201769 ESTs. Weakly similar to T24435 hypothed 90 147
412453 R20205 Hs 167330 ESTs 90 13 7
408920 AL120071 Hs 48998 fibronectin leucine πch transmembrane p 89 173
409031 AA376836 Hs 76728 ESTs 87 86
446544 AI631932 Hs 7047 ESTs, Weakly similar to Unknown [H sapie 82 200
439480 AL038511 Hs 125316 ESTs, Weakly similar to S33990 finger pr 82 83
410200 AA082557 Hs 101915 Stargardt disease 3 (autosomal dominant) 80 89 408428 NM.014787 Hs 44896 DnaJ (Hsp40) homolog subfamily B membe 79 96
437073 AI885608 Hs 94122 ESTs 79 11 3
408434 AW195317 Hs 107716 hypothetical protein FU 22344 79 164
440209 H05049 Hs 22269 neurexin 3 78 343
408119 W26213 Hs 101672 ESTs Weakly similar to T00331 hypotheti 78 90
429611 AI889077 Hs 211388 Homo sapiens BAC clone CTB-60N22 from 7q 77 50
423440 R25234 Hs 143434 contactin 1 77 99
445148 AI214510 Hs 146304 ESTs 76 9 1
416294 D86980 Hs 79170 KIAA0227 protein 76 76
424087 N69333 Hs 143434 contactin 1 76 103
437479 R61866 Hs 101277 ESTs 75 93
430573 AA744550 Hs 136345 ESTs 7 1 28
448958 AB020651 Hs 22653 KIAA0844 protein 7 1 104
419474 AW968619 Hs 155849 ESTs 7 1 30
423605 AF047826 Hs 129887 cadheπn 19, type 2 70 69
433098 AW190593 Hs 151143 ESTs 70 92
449511 AI436187 Hs 296261 guanine nudeodde binding protein (G pr 69 3 1
428414 AL049980 Hs 184216 DKFZP564C152 protein 68 50
443155 R54485 Hs 23772 ESTs 68 35
450561 R49674 Hs 25909 ESTs 68 8 1
433068 NM 006456 Hs 288215 sialyltransferase 68 20
423589 AA328082 Hs 209569 ESTs 66 105
415681 AI379882 Hs 72630 ESTs 65 90
413510 F13044 gb HSC3HH101 normalized infant brain cDN 64 7 1
427992 Y15014 Hs 181353 UDP-Gal betaGlcNAc beta 1,3-galactosyltr 64 95
450642 R39773 Hs 7130 copine IV 64 57
429322 D86984 Hs 199243 KIAA0231 protein 64 82
447482 AB033059 Hs 18705 KIAA1233 protein 64 23
446129 AW244073 Hs 145946 ESTs 63 83
421913 AI934365 Hs 109439 osteoglycin (osteoinducdve factor, mime 63 2 1
434273 AA913143 Hs 26303 ESTs 62 103
408480 AI350337 Hs 164568 fibroblast growth factor 7 (keratinocyte 62 35
451301 AI769514 Hs 209890 EST 62 124
438356 AA805530 Hs 48527 ESTs 62 81
426388 AW081394 Hs 97103 ESTs 62 86
452502 AI904296 gb PM BT046-220199-286J BT046 Homo sapi 6 1 28
408165 AL137573 Hs 43143 Homo sapiens mRNA cDNA 0KFZp564A2463 (f 6 1 63
442979 AW440782 Hs 174743 ESTs 6 1 63
408713 NM 001248 Hs 47042 ectonucleoside tπphosphate diphosphohyd 60 38
430004 U27768 Hs 227571 regulator of G-protem signalling 4 59 21 4
425087 R62424 Hs 126059 ESTs 59 8 1
441695 T12411 Hs 183745 hypothetical protein FLJ13456 59 3 1
417175 R44558 Hs 94002 ESTs 58 125
437483 AL390174 gb Homo sapiens mRNA, cONA DKFZp547J184 58 22
436427 AI344378 Hs 143399 ESTs 58 138
450382 AA397658 Hs 60257 Homo sapiens cDNA FU13598 fis, clone PL 57 44
408478 NM 000806 Hs 45740 gamma-aminobutync acid (GABA) A recepto 57 125
442676 AI733585 Hs 130897 ESTs 57 68
446443 AV659082 Hs 134228 ESTs 57 64
459080 AW192083 Hs 290855 ESTs 56 156
431984 AL080239 Hs 272284 Human DNA sequence from clone GS1-256022 56 82
428356 AL046991 Hs 10338 ESTs 56 62
417877 AI025829 Hs 86320 ESTs 54 49
429290 AF203032 Hs 198760 neurofilament, heavy polypepdde (200kD) 53 13 1
408556 U49516 Hs 46362 5-hydroxytryptamme (serotonin) receptor 53 66
431930 AB035301 Hs 272211 cadhenn 7, type 2 52 60
438285 AA782845 Hs 22790 ESTs 52 73
439901 N73885 Hs 124169 ESTs 52 27
449222 AW293984 Hs 197621 ESTs 52 8 1
408016 AW136827 Hs 256096 ESTs 5 1 25
436953 AW959074 Hs 23648 Homo sapiens cDNA FU13097 fis, clone NT 5 1 30
436773 AW078629 Hs 82110 PC4 and SFRS1 interacting protein 1 5 1 73
409263 AA069573 Hs 50319 ESTs 5 1 129
453830 AA534296 Hs 20953 ESTs 5 1 34
441535 AL135735 Hs 7885 phosphaddylinositol binding clathnn as 50 48
416490 AF090116 Hs 79348 regulator of G-protem signalling 7 50 20 1
417284 N62889 Hs 107242 Homo sapiens cDNA FU12965 fis, clone NT 50 39
448605 AL109678 Hs 21597 Homo sapiens mRNA full length insert cDN 50 6 1
442240 AI791883 Hs 292719 ESTs 49 67
427972 AA864870 Hs 181304 putadve gene product 49 52
416040 AW819158 Hs 289044 Homo sapiens cDNA FU 12048 fis, clone HE 49 28
444922 AI921750 Hs 144871 Homo sapiens cDNA FLJ13752 fis, clone PL 48 37
408936 AL138043 Hs 293549 ESTs 48 66
414943 D80647 Hs 124193 ESTs 48 3 1
429254 H10133 Hs 91846 hypothedcal protein DKFZp761C121 48 23
407906 AA369665 HS 41185 Homo sapiens mRNA, cDNA DKFZp56401262 (f 48 9 1
416577 BE063207 Hs 79381 grancalcin 47 22
420480 AL137361 Hs 98173 hypothetical protein 47 28
404793 46 22
430895 U66581 Hs 248121 G protein-coupled receptor 22 46 74
438571 AW020775 Hs 56022 ESTs 46 54
444585 AW170015 Hs 6594 ESTs 46 60
414272 AI651603 Hs 46988 ESTs 45 22 414699 AI815523 Hs 76930 synuclein, alpha (non A4 component of am 4 5 309
423449 AI497900 Hs 33067 ESTs 4 5 208
433521 T66087 Hs 112482 Homo sapiens unknown mRNA sequence 4 4 20
429876 AB028977 Hs 225974 KIAA1054 protein 44 192
429726 AW628326 Hs 27151 ESTs 4 4 102
449093 AB035356 Hs 22998 neurexin 1 44 94
415716 N59294 Hs 179662 nucleosome assembly protein 1-lιke 1 44 151
419656 AB02314 Hs 92025 KIAA0316 gene product 4 4 82
425864 U56420 Hs 159903 olfactory receptor, family 5, subfamily 44 24
435078 AW518888 Hs 40937 ESTs 44 57
432712 AB016247 Hs 288031 sterol-C5-desaturase (fungal ERG3, delta 43 59
426867 AA460967 Hs 22668 ESTs 4 3 60
412112 BE180342 gb RC3-HT0622-130400-012-a07 HT0622 Homo 43 32
410171 H07892 Hs 12431 ESTs 43 53
442339 BE299668 Hs 227591 ESTs, Weakly similar to 1901303A Leu zip 4 2 50
421249 AA285362 gb HTH277 HTCDL1 Homo sapiens cDNA 513 42 35
422528 AB011182 Hs 118087 KIAA0610 protein 42 39
434460 AA478486 Hs 3852 KIAA0368 protein 4 1 83
410362 H04811 Hs 93164 proprotein convertase subd sin/kexin t 4 1 70
449754 H00820 Hs30977 ESTs, Weakly similar to B34087 hypothed 4 1 39
408496 AI683802 Hs 136182 ESTs 4 1 47
434101 AA625205 Hs 259599 KIAA1622 protein 4 1 63
430212 AA469153 gb πc67f04 s1 NCI.CGAP.Pr1 Homo sapiens 40 25
453165 S74727 Hs 32042 aspartoacylase (aminoacyl-.se 2, Canavan 40 74
456407 AW968614 gb EST380690 MAGE resequences, MAGJ Homo 40 51
441869 NM 003947 Hs8004 hunbngdn-associated protein interacdn 40 323
429628 H09604 Hs 13268 ESTs 40 45
410087 F12079 Hs 332579 ESTs 40 69
419910 AA662913 Hs 190173 ESTs, Weakly similar to A46010 X-linked 40 26
441005 Z41305 Hs 303172 Homo sapiens mRNA cDNA DKFZp547G133 (fr 39 217
412677 AW029608 Hs 17384 ESTs 39 22
453341 AI758912 Hs 296341 adenylyl cyclase-associated protein 2 39 72
416854 H40164 Hs 80296 Purkinie cell protein 4 39 22
414666 NM 004466 Hs 76828 glypican 5 38 62
418217 AI910647 Hs 13442 ESTs 38 32
421855 F06504 Hs 27384 ESTs. Moderately similar to ALU4.HUMAN A 38 22
414764 AW013887 Hs 72047 ESTs 38 107
433629 R13140 Hs 13359 ESTs 37 27
424738 AI963740 Hs46826 ESTs 37 21
407706 AA191085 Hs 26612 ESTs, Moderately similar to S23650 retro 37 53
437268 AI754847 Hs 227571 regulator of G-protem signalling 4 37 537
423135 N67655 Hs 26411 ESTs 37 217
446818 AI342668 Hs 279765 ESTs 37 26
427562 R56424 Hs 26534 ESTs 36 36
439274 AF086092 Hs 48372 ESTs 36 345
452381 H23329 Hs 290880 ESTs, Weakly similar to ALU1.HUMAN ALU S 36 60
422897 AA679784 Hs4290 ESTs 36 51
429656 X05608 Hs 211584 neurofilament, light polypepdde (68kD) 36 246
417154 AI674701 Hs 21388 ESTs 36 58
447176 Z42549 Hs 160893 ESTs 36 64
405977 36 39
423568 NM.005256 Hs 129818 growth arrest specific 2 36 25
441235 AI884586 Hs 135570 Homo sapiens cDNA FLJ21268 fis, clone C 36 54
426775 AA384564 Hs 108829 ESTs 36 34
414831 M31158 Hs 77439 protein kinase, cAMP-dependent regulato 36 28
425153 AW023193 Hs 27046 ESTs 36 49
446495 D60923 Hs 153460 ESTs 35 98
445898 AF070623 Hs 13423 Homo sapiens done 24468 mRNA sequence 3 5 166
416421 AA134006 Hs 79306 eukaryodc translation inidadon factor 35 50
418207 C14685 Hs 34772 ESTs 35 160
425383 D83407 Hs 156007 Down syndrome cntical region gene 1 lik 3 5 62
417027 AA192306 Hs 23926 tnadm 35 25
408367 AK001178 Hs44424 homolog of rat orphan transporter v7-3 3 5 53
408776 AA057365 Hs 63356 ESTs, Weakly similar to I38022 hypothed 35 55
453220 AB033089 Hs 32452 Homo sapiens mRNA for KIAA1 63 protein, 35 236
419347 C15944 Hs90005 supeπorcervical ganglia, neural specifi 35 423
433803 AI823593 Hs 27688 ESTs 34 36
450715 AI266484 Hs31570 ESTs, Weakly similar to KIAA1324 protein 34 41
415076 NM 000857 Hs 77890 guanylate cyclase 1 , soluble, beta 3 34 98
423826 U20325 Hs 1707 cocaine- and amphetamine-regulated trans 34 47
427173 BE255017 Hs 97540 ESTs 34 24
446092 N33522 Hs 145894 ESTs 34 35
416868 AI656856 Hs 292597 ESTs 34 45
458234 BE551408 Hs 127196 ESTs 34 45
434053 AW445136 Hs 134946 ESTs 34 39
428536 AI143139 Hs2288 visimn-like 1 33 423
410366 AI267589 Hs 302689 hypothedcal protein 33 144
425785 T27017 Hs 159528 Homo sapiens clone 24400 mRNA sequence 3 3 46
434998 AW975157 Hs 26037 ESTs 33 47
456359 AI967991 Hs93574 homeo box D3 33 44
426527 NM 001037 Hs 170238 sodium channel, voltage-gated, type I, b 33 52
400302 N48056 HS1915 folate hydrolase (prostate-specific memb 33 90
419875 AA853410 Hs93557 proenkephalm 33 36 444612 AW138111 Hs 22902 ESTs 33 30
415242 R45986 Hs 295014 ESTs 32 22
421640 AW966652 gb EST378726 MAGE resequences, MAGI Homo 32 38
408806 AW847814 Hs 289005 Homo sapiens cDNA FU21532 fis, clone C 32 24
446015 T30968 Hs 13531 hypothedcal protein FU10971 32 32
425495 AA358454 Hs 78026 ESTs, Weakly similar to similar to ankyr 32 22
403092 32 29
452971 AI873878 Hs 91789 ESTs 32 45
454100 AI693231 Hs 126043 chromosome 21 open reading frame 51 32 27
448440 AA173467 Hs 62402 p21/Cdc42/Rac1-actιvated kinase 1 (yeast 32 28
421200 AA284811 Hs 264433 ESTs 32 27
440827 AI733110 Hs 128128 ESTs 32 2 1
429809 AL162010 Hs 223603 Homo sapiens mRNA, cDNA DKFZp761 D09121 ( 32 43
420156 AW449258 Hs 6187 ESTs 32 190
457535 AA609685 Hs 278672 membrane component chromosome 11, surfa 32 20
419956 AL137939 Hs 40096 ESTs 3 1 87
423930 AA332697 Hs 42721 ESTs 31 27
417868 AI078534 Hs 122592 ESTs 3 1 126
423346 AI267677 Hs 127416 synaptojanin 1 31 120
441921 AI733376 Hs 164478 hypothetical protein FU21939 similar to 3 1 43
429470 AI878901 Hs 203862 guanine nudeodde binding protein (G pr 3 1 53
408217 AI433201 Hs 279860 tumor protein, transladonally-controlle 31 7 1
427322 AK002017 Hs 176227 hypothedcal protein FU11155 31 63
449078 AK001256 Hs 22975 KIAA1576 protein 31 30 1
429608 U49250 Hs 210862 T-box, brain, 1 31 22
442308 AA989402 Hs 111 fibroblast growth factor 9 (glia-acdvat 3 1 30
411666 AF106564 Hs 71346 neurofilament 3 (150kD medium) 31 109
427865 AA416931 Hs 126065 ESTs 31 75
430708 U78308 Hs 278485 olfactory receptor, family 1, subfamily 31 34
451829 AW964081 Hs 247377 ESTs 30 62
405911 30 24
418808 AI821836 Hs 10359 ESTs 30 62
452893 H18017 Hs 22869 ESTs, Moderately similar to KIAA1395 pro 30 51
423952 AW877787 Hs 136102 KIAA0853 protein 30 2 1
412000 AW576555 Hs 15780 ATP-bindmg cassette, sub-family A (ABC1 30 2 1
405793 30 27
410711 AB002316 Hs 65746 KIAA0318 protein 30 143
427071 AA397958 Hs 192719 ESTs 30 2 1
453534 NM 014796 Hs 33187 KIAA0748 gene product 30 14 5
413903 AA496493 Hs 23136 ESTs 30 22
426866 U02330 Hs 172816 neuregulm 1 30 11 3
434945 AB033065 Hs 4280 KIAA1239 protein 30 35
412639 AW961284 Hs 296235 ESTs 29 49
453590 AF150278 Hs 33578 KIAA0820 protein 29 33 1
414502 AL133721 Hs 224680 ESTs 29 23
434367 AB02070O Hs 3830 KIAA0893 protein 29 23 1
425121 AI797511 Hs 154679 synaptotagmin I 29 8 1
412494 AL133900 Hs 792 ADP-nbosyladon factor domain protein 1 29 208
401213 29 32
401028 AW673312 Hs 50848 hypothetical protein FLJ20331 29 34
415191 AA190381 Hs 120810 ESTs 29 30
449275 AW450848 Hs 205457 penaxin 29 56
419863 AW952691 Hs 93485 Homo sapiens mRNA, cDNA DKFZp761D191 (fr 29 350
411421 BE272110 Hs 21177 ESTs 29 20
430865 AI073424 Hs 5232 HSPC125 protein 29 11 4
437486 AW952089 Hs 5636 RAB6A, member RAS oncogene family 29 22
442357 AI458586 Hs 135706 ESTs 29 60
408274 R17315 gb yg12g11 r1 Soares infant brain 1NIB H 29 22
444185 AW298350 Hs 66020 ESTs 28 50
420173 AA256151 Hs 22999 ESTs 28 51
428358 AA993222 Hs 101915 Stargardt disease 3 (autosomal dominant) 28 70
447252 R90916 Hs 12449 Homo sapiens transmembrane protein HTMP1 28 44
440260 AI972867 Hs 7130 copme IV 28 106
417084 H08370 Hs 33067 ESTs 28 84
438257 AW474419 Hs 224794 ESTs 28 28
441934 T23939 Hs 7344 ESTs 28 62
447885 F11528 Hs 303172 Homo sapiens mRNA, cDNA DKFZp547G133 (fr 28 35
423552 AF107028 Hs 129783 sodium channel, voltage-gated, type II, 28 34
450940 AI744943 Hs 143209 ESTs, Weakly similar to I38022 hypothed 28 144
410011 AB020641 Hs 57856 PFTAIRE protein kinase 1 28 21 7
445887 AI263105 Hs 145597 ESTs 28 5 1
425494 N55540 Hs 78026 ESTs, Weakly similar to similar to ankyr 28 24
438202 AW169287 Hs 22588 ESTs 28 11 9
436199 R38946 Hs 127951 hypothetical protein FU 14503 28 60
434826 AF155661 Hs 22265 pyruvate dehydrogenase phosphatase 28 24
415462 R52692 Hs 12698 ESTs 28 34
418070 NM 000844 Hs 83407 glutamate receptor, metabotropic 7 28 45
432149 AW614326 Hs 157022 ESTs, Weakly similar to T34549 probable 28 95
430371 D87466 Hs 240112 KIAA0276 protein 28 70
437357 AL359559 Hs 331666 Homo sapiens mRNA, cDNA DKFZp76202215 (f 27 25
415838 R44336 Hs 7093 ESTs 27 36
438675 AA813725 Hs 213568 ESTs 27 25
419558 AW953679 gb EST365749 MAGE resequences, MAGC Homo 27 31 446318 AI949389 Hs 18067 ESTs 27 4 1
445183 AB007877 Hs 12385 KIAA0417 gene product 27 53
457012 R41480 Hs 127630 ESTs 27 19 0
431988 AC002302 Hs 77202 protein kinase C, beta 1 27 72
430223 NM 002514 Hs 235935 nephroblastoma overexpressed gene 27 28
447932 AA8~37474 Hs 20021 vesicle-associated membrane protein 1 (s 27 38
450214 BE439763 Hs 227571 regulator of G-protem signalling 4 27 69
434731 AA648049 Hs 121518 ESTs 27 50
428839 AI767756 Hs 82302 Homo sapiens cDNA FU14814 fis, clone NT 27 52
407709 AA456135 Hs 23023 ESTs 27 25
422420 U03398 Hs 1524 tumor necrosis factor (ligand) superfami 27 33
443305 AI050693 Hs 133318 ESTs 27 59
435648 H24347 Hs 27524 ESTs 27 150
418407 AL044818 Hs 84928 nuclear transcnpdon factor Y, beta 27 27
436771 AW975687 Hs 292979 ESTs 27 60
428689 NM 014351 Hs 189810 sulfortranferase family 4A, member 1 27 48
440503 NM 006539 Hs 7235 calcium channel, voltage-dependent gamm 27 44
441006 AW605267 Hs 7627 CGI-60 protein 27 3 1
410330 AW023630 Hs 46786 ESTs 26 295
434398 AA121098 Hs 3838 serum-mducible kinase 26 26
438831 BE263273 Hs 6439 synaps II 26 78
419066 Z98492 Hs 6975 PR01073 protein 26 34
412643 AW971239 Hs 293982 ESTs 26 22
430456 AA314998 Hs 241503 hypothedcal protein 26 17 9
416498 U33632 Hs 79351 potassium channel, subfamily K, member 1 26 29
401421 26 20
419530 X98330 Hs 90821 ryanodine receptor 2 (cardiac) 26 42
441817 AW969706 Hs 293332 ESTs 26 38
439203 AA448930 Hs 8453 KIAA1587 protein 26 42
426054 U12431 Hs 166109 ELAV (embryonic lethal, abnormal vision, 26 5 1
444583 AW994403 Hs 100861 hypothedcal protein FLJ 14600 26 37
417919 AI928203 Hs 86379 ESTs 26 30
434293 NM.004445 Hs 3796 EphB6 26 32
431716 D89053 Hs 268012 fatty-aαd-Coenzyme A ligase, long-chain 26 64
443037 AW500305 Hs 299166 syntaxin 7 26 22
440736 D56919 Hs 265848 myomegalin 26 7 1
404648 26 30
429995 AA463571 gb zx72e09 r1 Soares_total_fetus_Nb2HF8_ 26 35
436508 AW604381 Hs 121121 ESTs, Weakly similar to S00755 plecksto 26 39
441190 H09073 Hs 25046 ESTs 26 3 1
432278 AL137506 Hs 274256 hypothetical protein FU23563 26 29
442731 AI868167 Hs 131044 ESTs 26 41
416836 D54745 Hs 80247 cholecystokinm 26 149
449071 NM_005872 Hs 22960 breast carcinoma amplified sequence 2 25 24
436321 AA709133 Hs 180144 ESTs 25 28
439693 AI741816 Hs 125897 ESTs 25 36
443212 AW269515 Hs 102500 hypothedcal protein FLJ20481 25 28
423981 AL122104 Hs 136664 Homo sapiens mRNA, cDNA DKFZp434A1627 (f 25 38
407868 NM 000950 Hs 40637 proline-πch Gla (G-carboxyglutamic acid 25 3 1
443992 AW022228 Hs 322922 ESTs 25 279
444124 R43097 Hs 6818 ESTs 25 53
411379 AI816344 Hs 12554 ESTs, Weakly similar to NPL4.HUMAN NUCLE 25 380
440474 AI207936 Hs 7195 gamma-aminobutync acid (GABA) A recepto 25 38
446277 AI284218 Hs 159204 ESTs 25 22
410111 AI620206 Hs 189647 ESTs 25 35
445162 AB011131 Hs 12376 piccolo (presynapdc cytomatπx protein) 25 48
410718 AI920783 Hs 191435 ESTs 25 45
417201 T60432 Hs 269084 ESTs, Moderately similar to AF097994 1 L 25 29
420274 AW968000 Hs 143389 ESTs, Weakly similar to T14318 ubiquitin 25 28
433496 AF064254 Hs 49765 VLCS-H1 protein 25 47
437331 AL353933 Hs 21710 hypothetical protein DKFZp761G0313 25 33
437368 AI471969 Hs 182606 ESTs 25 30
441985 BE047625 Hs 169815 ESTs 25 36
410025 BE220489 Hs 113592 ESTs, Moderately similar to I54374 gene 25 92
414680 AA743331 Hs 272572 hemoglobin, alpha 2 25 36
429956 AI374651 Hs 22542 ESTs 25 239
429028 AA443439 Hs 48797 ESTs 25 28
438109 AI076621 HS 71367 ESTs, Moderately similar to ALU7_HUMAN A 25 31
439780 AL109688 gb Homo sapiens mRNA full length insert 25 23
440888 N45600 Hs 326880 ESTs 25 39
445246 AI217713 Hs 147586 ESTs 25 26
440152 AB002376 Hs 70O6 KIAA0378 protein 24 236
432740 AF061034 Hs 278898 tumor necrosis factor alpha-mducible ce 24 2 1
415122 D60708 Hs 22245 ESTs 24 39
432298 AL118812 Hs 274293 Homo sapiens mRNA, cDNA DKFZp761 G1111 (f 24 98
437948 AA772920 Hs 303527 ESTs 24 98
421360 AA297012 Hs 103839 erythrocyte membrane protein band 4 1-lι 24 28
427115 AW972853 Hs 112237 ESTs 24 22
452074 BE299035 Hs 27747 G protein-coupled receptor 37 (endotheli 24 100
436639 D14838 Hs 111 fibroblast growth factor 9 (glia-acdvat 24 35
434520 AA205273 Hs 177011 hypothedcal protein 24 3 1
411529 AA430348 Hs 317596 Homo sapiens cDNA FU12927 fis, clone NT 24 30
442272 AA988302 Hs 129172 ESTs 24 21 422927 AW247388 Hs 301423 calcium binding protein 1 (calbrain) 24 27
444647 H14718 Hs 11506 Human clone 23589 mRNA sequence 24 28
415827 H17462 Hs 23079 ESTs 24 150
451397 AA017432 Hs 84529 ESTs, Weakly similar to Z202.HUMAN ZINC 24 39
445200 AA084460 Hs 12409 somatostadn 24 37
451062 AL110125 Hs 25910 Homo sapiens mRNA, cDNA DKFZp564C1416 (f 24 24
420328 Y19062 Hs 96870 staufeπ (Drosophila, RNA-bmding protein 24 43
432122 AA526514 gb nι60f02 s1 NCI CGAP Ov2 Homo sapiens 24 43
444125 AI124882 Hs 118121 ESTs 24 35
430538 AB032435 Hs 242821 differendadon-associated a-dependent 24 108
457519 X69438 Hs 3052 earty growth response 4 24 24
409371 R51736 Hs 12381 ESTs 24 2 1
456303 AA224872 Hs 115088 ESTs 24 32
440105 AA694010 Hs 6932 Homo sapiens clone 23809 mRNA sequence 24 234
400979 24 4 1
435296 R49685 Hs 24980 ESTs 24 65
408950 AA707814 Hs 14945 long fatty acyl-CoA synthetase 2 gene 24 185
452032 BE244005 Hs 27610 rednoic acid- and interferon-inducible 24 22
432098 AF252297 Hs 91546 cytochrome P450 rednoid metabolizing pr 24 27
408974 AW015458 Hs 297017 ESTs 24 25
412177 Z23091 Hs 73734 glycoprotein V (platelet) 24 28
413153 N94205 gb za27a08 r1 Soares fetal liver spleen 24 25
417583 AA668782 Hs 191284 ESTs, Weakly similar to ALU1_HUMAN ALU S 24 26
452034 F12234 Hs 75893 ankyπn 3, node of Ranvier (ankyπn G) 23 30
424940 AA985308 Hs 194327 ESTs 23 63
431706 AI816086 Hs 296341 adenylylcyclase-associated protein 2 23 41
419125 AA642452 Hs 130881 B-cell CLL/lymphoma 11 A (zinc finger pro 23 29
423641 AL137256 Hs 130489 ATPase, ammophospholipid transporter-li 23 87
436407 T88803 Hs 271507 ESTs, Weakly similar to TIM.HUMAN PROBAB 23 32
448681 AL109781 Hs 21754 Homo sapiens mRNA full length insert cDN 23 52
415669 NM 005025 Hs 78589 senne (or cysteine) proteinase inhibito 23 547
410765 AI694972 Hs 66180 nucleosome assembly protein 1-lιke 2 23 9 1
422386 AF105374 Hs 115830 heparan sulfate (glucosamine) 3-O-sulfot 23 50
414828 AA156651 gb zl05h05 r1 Soares_pregnant_uterus_NbH 23 24
445556 AI910241 Hs 12887 acdn-related protein 3-beta 23 85
426968 U07616 Hs 173034 amphiphysm (Sdff-Mann syndrome with br 23 263
444562 AA186715 Hs 336429 RIKEN cDNA 9130422N19 gene 23 25
423420 AI571364 Hs 128382 Homo sapiens mRNA, cDNA DKFZp761l1224 (f 23 76
439450 R51613 Hs 125304 ESTs 23 263
427127 AW802282 Hs 22265 pyruvate dehydrogenase phosphatase 23 22
447179 AW015633 Hs 157299 ESTs 23 38
414711 AI310440 Hs 288735 Homo sapiens cDNA FU 13522 fis, clone PL 23 23
433449 AW772282 gb hn71b05 x1 NCI_CGAP_Kι 11 Homo sapien 23 38
414320 U13616 Hs 75893 ankynn 3, node of Ranvier (ankyππ G) 23 25
416778 M16505 Hs 79876 steroid sulfatase (microsomal), arγlsulf 23 78
425130 AA448208 Hs 99163 ESTs 23 4 1
456664 AW963354 Hs 334409 metallothionein 1G 23 25
438283 AI458931 Hs 37282 ESTs 23 42
417455 AW007066 Hs 18949 ESTs, Weakly similar to CA2B_HUMAN COLLA 23 30
412100 AW892731 gb CMO-NN0005-100300-279-C02 NN0005 Homo 23 37
448981 AI968719 Hs 195387 ESTs 23 32
416101 R24854 Hs 268806 ESTs 23 65
439731 AI953135 Hs 45140 hypothedcal protein FLJ14084 23 17 8
415734 NM 014747 Hs 78748 KIAA0237 gene product 23 40 1
424596 AB020639 Hs 151017 estrogen-related receptor gamma 23 29
420230 AL034344 Hs 284186 forkhead box C1 23 24
451559 AL119980 Hs 20935 hypothedcal protein DKFZp761D221 23 57
404835 23 21
456765 AI497900 Hs 33067 ESTs 23 4 1
455517 AW984068 gb RCO-HN0006-160300-011-e06 HN0006 Homo 23 24
408206 AF041853 Hs 43670 kinesin family member 3A 22 18 5
411770 NM 014278 Hs 71992 heal shock protein (hspl 10 family) 22 39
430105 X70297 Hs 2540 chol ergic receptor, nicotmic, alpha p 22 26
458694 F12832 Hs 13298 ESTs 22 49
415091 AL044872 Hs 77910 3-hydroxy-3-methylglutaryl-Coenzyme A sy 22 44
439642 W81441 Hs 153967 ESTs 22 24
450138 AW152104 Hs 200879 ESTs 22 49
454222 BE144344 Hs 7589 ESTs Weakly similar to A46010 X-lιnked 22 37
405326 22 27
431342 AW971018 Hs 21659 ESTs 22 52
453101 AW952776 Hs 94943 ESTs 22 33
408897 N50204 Hs 283709 lipopolysacchande specific response-7 p 22 28
451398 AI793124 Hs 144479 ESTs 22 46
438208 AL041224 Hs 65379 ESTs 22 104
408449 NM 004408 Hs 166161 dynamm 1 22 6 1
414130 AI670831 Hs 71592 Homo sapiens cDNA FLJ21893 fis, clone H 22 3 1
445016 U79716 Hs 12246 reelin 22 39
424375 AF070547 Hs 146312 Homo sapiens clone 24820 mRNA sequence 22 23
424645 NM 014682 Hs 151449 KIAA0535 gene product 22 11 7
409729 D51315 Hs 106289 ESTs 22 49
432809 AA565509 Hs 131703 ESTs 22 199
422890 Z43784 Hs 75893 ankyπn 3 node of Ranvier (ankyπn G) 22 104
428532 AF157326 Hs 184786 TBP-interacdng protein 22 65 413074 AI871368 Hs 8417 hypothedcal protein DKFZp761M0423 22 34
414442 AA156238 Hs 32501 ESTs 22 32
452768 AW069459 Hs 61539 ESTs 22 20
450440 AB024334 Hs 25001 tyrosine 3-monooxygenase/tryptophan 5-mo 22 32
426281 AK000987 Hs 169111 oxidadon resistance 1 22 23
428411 AW291464 Hs 10338 ESTs 22 23
413787 AI352558 Hs 75544 tyrosine 3-monooxygenase/tryptophan 5-mo 22 3.1
451734 NM 006176 Hs 26944 neurogranin (protein kinase C substrate, 22 85
439108 Aw!δ3034 Hs 6467 synaptogyπn 3 22 79
405385 22 24
447285 AI371849 Hs 200696 ATPase, Class VI, type 11C 22 22
452667 T87219 Hs 13219 ESTs 22 3 1
422234 AF119818 Hs 113287 discs, large (Drosophila) homolog-associ 2 1 83
410339 AI916499 Hs 298258 ESTs 2 1 32
413231 D87461 Hs 75244 BCL2-lιke 2 2 1 45
447104 R19085 Hs 210706 Homo sapiens cDNA FU13182 fis, clone NT 21 22
451952 AL120173 Hs 301663 ESTs 2 1 365
415841 Z45637 Hs 7093 ESTs 2 1 24
441086 AI928489 Hs 213490 ESTs, Weakly similar to N33.HUMAN N33 PR 21 22
450407 NM.000810 Hs 24969 gamma-aminobutync acid (GABA) A recepto 21 66
427627 R87582 Hs 179915 guanine nudeodde binding protein (G pr 2 1 53
449712 R56545 Hs 6100 ESTs 21 45
409660 AW452065 Hs 258905 ESTs 21 21
430434 AL049548 Hs 241420 Homo sapiens mRNA for KIAA1756 protein, 2 1 54
434138 AA625804 gb zu86h01 s1 Soares_tesds_NHT Homo sap 2 1 30
448610 NM 006157 Hs 21602 nel (chιcken)-lιke 1 21 48
418948 AI217097 gb qd43h07 x1 Soares_fetal.heart_NbHH19W 2 1 29
414876 AW950925 Hs 924 crγstallin, mu 2 1 34
440426 AI15980O Hs 7181 Homo sapiens cDNA FU13663 fis, clone PL 2 1 37
451249 AA016227 Hs 27280 ESTs 2 1 4 1
451475 T19093 Hs 26450 KIAA0725 protein 21 21
448743 AB032962 Hs 21896 KIAA1136 protein 2 1 297
430814 U89336 Hs 247993 NG5 protein 2 1 27
426990 AL044315 Hs 173094 Homo sapiens mRNA for KIAA1750 protein. 2 1 23
426642 AW068223 Hs 171581 ubiquitin C-terminal hydrolase UCH37 2 1 45
427335 AA448542 Hs 251677 G andgen 7B 2 1 22
459089 F13036 Hs 27373 Homo sapiens mRNA, cDNA DKFZp56401763 (f 2 1 23
435832 AA425688 Hs 41641 Bruno (Drosophila) -like 4, RNA binding 2 1 59
446383 T05816 Hs 92511 ESTs 2 1 29
412768 AW996044 Hs 26239 Human DNA sequence from clone RP11-438B2 21 21
453976 BE463830 Hs 163714 ESTs 2 1 42
415111 R39039 Hs 328455 EST 2 1 33
452238 F01811 Hs 187931 ESTs 21 49
445279 R41900 Hs 22245 ESTs 2 1 98
448799 AI937094 Hs 179080 ESTs 2 1 3 1
418338 NM 002522 Hs 84154 neuronal pentraxin I 21 83
445725 AK000956 Hs 13209 hypothedcal protein FU10094 2 1 54
443537 D13305 Hs 203 cholecystokinin B receptor 2 1 4 1
454066 X00356 Hs 37058 calcitonin/calcitonin-related polypepdd 2 1 64
429954 AI918130 Hs 21374 ESTs 2 1 72
415292 H29016 Hs 200576 ESTs 2 1 39
423563 R34734 Hs 75209 protein kinase (cAMP-dependent, catalyd 2 1 3 1
424906 AI566086 Hs 153716 Homo sapiens mRNA for Hmob33 protein, 3 2 1 47
459309 AA040620 Hs 5672 hypothetical protein AF140225 2 1 22
439340 AB032436 Hs 6535 brain specific Na-dependent inorganic ph 21 47
402598 BE314624 Hs 3128 polymerase (RNA) II (DNA directed) polyp 2 1 54
435406 F26698 Hs 4884 calcium/calmoduliπ-dependent protein km 2 1 66
448792 R42550 Hs 12826 ESTs 2 1 4 1
449500 AW956345 Hs 12926 ESTs 2 1 24
441134 W29092 Hs 7678 cellular retinoic acid-binding protein 1 21 58
433361 AW469373 Hs 300141 πbosomal protein L39 2 1 27
452946 X95425 Hs 31092 EphA5 2 1 50
426167 AF039023 Hs 167496 RAN binding protein 6 20 22
453666 AW015681 Hs 135229 ESTs, Weakly similar to A2BP_HUMAN ATAXI 20 3 1
424632 AB014523 Hs 151406 K1AA0623 gene product 20 35
448589 AF017090 Hs 21554 KIAA1107 protein 20 4 1
430416 AC005531 Hs 57806 Homo sapiens PAC clone RP4-701O16 from 7 20 23
445627 AW818475 Hs 7363 ESTs 20 2 1
417092 H97508 Hs 181165 eukaryotic translation elongadon factor 20 25
453653 AW505554 Hs 144559 ESTs 20 47
435850 AF250847 Hs 283514 mitochondnal ceramidase 20 37
435086 AW975243 Hs 122596 ESTs 20 2 1
423191 D61506 Hs 8417 hypothetical protein DKFZp761M0423 20 2 1
411562 AL050201 Hs 70769 hypothetical protein DKFZp586E1923 20 28
431645 AF078849 Hs 266483 dynein light cham-A 20 25
429834 AI929645 Hs 225936 synaps I 20 36
439607 BE540565 Hs 159460 ESTs 20 17 5
408033 AW138045 Hs 242256 ESTs 20 40
430317 AB020645 Hs 239189 glutaminase 20 27
419631 AW188117 Hs 303154 popeye protein 3 20 26
432660 AI288430 Hs 64004 ESTs 20 23
454048 H05626 Hs 6921 ESTs 20 159
426917 AA913814 Hs 172854 DKFZP586B0923 protein 20 3 1 423246 AL119114 Hs 77196 spectπn, alpha, non-erythrocydc 1 (alp 20 29
415989 AI267700 Hs 317584 ESTs 20 48
420276 AA290938 Hs 190561 ESTs. Highly similar to SORL HUMAN SORTI 20 5 1
424983 AI742434 Hs 169911 ESTs 20 159
446296 AA985662 Hs 63131 Homo sapiens cDNA FLJ13155 fis. clone NT 20 27
450006 AI241555 Hs 60171 ESTs 20 35
TABLE 27B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession 408274 104999 R17315 Z43964AA053547 412100 1277224.1 AW892731 H08502 Z45826 412112 1277883 1 BE180342 BE180347 AW9019O0 BE180222 BE180218 BE180226 BE180413 BE180416 AW901899 BE180228 AW901897 BE180224 AW901898
BE180223 BE180219 BE180346 BE180343 BE180418 BE180225 BE180221 BE180341 AW901894 BE180217 BE180227 AW901891 BE180345
AW893614 AW893615 H85799 H83501 BE180220
413153 1350849.1 N94205 BE067565 BE067556 413510 1374377 1 F13044 T77009 BE145525 BE145493 414828 149563.1 AA156651 AA156622 R14472 418948 180808 1 AI217097 AW886090 W38035 W38792 AA232835 AW936043 419558 185904.1 AW953679 AW953680 AA244436 H82527 AA361046 AA244483 H82526 421249 200649.1 AA285362 AW752386 AW847156 AA285373 AW879575 AW879558 421640 204833.1 AW966652 AW966653 AA294989 AA385977 429995 311738.1 AA463571 AI277645 AL118763 430212 314437.1 AA469153 AI718503 AA469225 432122 341756 1 AA526514 AW973343 AA554293 433449 366532.1 AW772282 AA592974 434138 380572.1 AA625804 AW418787 AW074833 AI675642 AI393368 437483 43756.1 AL390174 AW898817 439780 47673.1 AL109688 R23665 R26578 452502 919733.1 AI904296 BE007223 R30687 455517 1321782.1 AW984068 AW984072 AW984077 456407 184986.1 AW968614 AA243209 AA281411
TABLE 27C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers 'Dunham, et al * refers to the publication endded "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted Nt_posιdon Indicates nucleotide posidons of predicted exons
Pkey Ref Strand Nt_posιdon
400979 8072554 Plus 160842-161028
401213 9858408 Plus 98243-98380,98489-98619
401421 7452889 Minus 142291-142461
403092 8954241 Plus 174720-175016,175104-175406,175508-175813
404648 9796894 Minus 115334-116020
404793 7232206 Minus 61087-61590
404835 6970743 Plus 85462-85684,88139-88287,90338-91018,94827-94990
405326 4375975 Plus 10633-1070930805-3089338078-3825355112-55327,57718-57818,66696-66841
405385 6552772 Plus 48332-48454
405793 1405887 Minus 89197-89453
405911 6758795 Plus 101008 101643
405977 8247789 Minus 135548-136177
TA8LE 28A About 139 genes up-regulated in glioma compared to no ial adult dssues
Table 28A lists about 139 genes up-regulated in glioma compared to normal adult dssues In order to idendfy new genes that are associated with glioma, a non redundant set of 6614 genes that have been previously identified were removed from the starting collection of 59680 probesets on the Affymetπx/Eos-Hu03 GeneChip® array Genes associated with glioma were selected from the remaining 53005 probesets such that the rado of "average" glioma to "average" normal adult dssues was greater than or equal to 25. and the "average" glioma value was greater than or equal to 50 units (this selects for the most abundant of the up-regulated genes) The "average" glioma level was set to the 94th percentile value amongst vanou glioblastoma, astrocytoma, and oligodendroglioma specimens the "average" normal adult tissue level was set to the 85th percentile value amongst vaπous non malignant organs and tissues and other non-malignant bran dssues In order to remove gene-specific background levels of non-specific hybπdizadon, the 15th percendle value amongst vaπous non malignant dssues was subtracted from both Ihe numerator and the denominator before the rado was evaluated Predicted protein domains are noted
Pkey Unique Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene title
Prot Doms i Predicted Protein Domains
R1 glioma vs normal adult dssues
Pkey ExAccn UπiGene ID Unigene Tide Protein Domains R1
443902 W28470 Hs 12600 N-ethylmaleimide-sensitive factor a 40
441476 R44566 Hs 173134 ESTs 40
446048 AI272364 Hs 182081 KIAA1811 protein 38
407061 X97748 gb H sapiens PTX3 gene promotor reg 37
414323 NM 014759 Hs 334688 KIAA0273 gene product fn3,TM, 36
439769 AA448828 Hs 30596 Homo sapiens mRNA full length inser lactamase.B.Rhomboid.TPR 36
429319 AL023754 Hs 199068 similar to calαum/calmodulin depen pkmase TM.SS 36
443412 W84893 Hs 9305 angiotensin receptor-like 1 35
425533 T47802 Hs 9305 angiotens receptor-like 1 35 408610 AW026692 Hs 285050 ESTs ιon_trans.K_tetra,Kv2chan 34
450678 AL109703 Hs 25314 Homo sapiens mRNA full length inser 34
419171 NM 002846 Hs 89655 protein tyrosine phosphatase. recep Y_phosphatase,ART,TM,SS 34
445875 AF070524 Hs 13410 Homo sapiens clone 24453 mRNA seque 34
412581 AA224244 Hs 182704 ESTs, Moderately similar to alterna 33
424911 AA984364 Hs 7913 ESTs 33
452753 AA028049 Hs 277728 SEC14 (S cerevιsιae)-lιke 2 CRALJRIO 33
436648 R18656 Hs 352385 ESTs pkιnase,pkιnase_C,PMP22_C 32
452130 AW248349 Hs 28088 SGC32445 protein TB2_DP1_HVA22,TM,SS 32
448848 AF131851 Hs 22241 hypothetical protein 32
426470 AA528794 Hs 128644 ESTs 32
419344 U94905 Hs 277445 diacylglycerol kinase, zeta (104kD) ank,DAGKa,DAGKc,DAG_PE-bι 32
439783 AI125760 Hs 24835 hypothetical protein FU 14594 ιg,LRR,LRRNT,LRRCT,TM,S 32
411358 R47479 Hs 94761 KIAA1691 protem TM.SS 32
409433 AA074382 Hs 135255 ADAMTS14 32
456940 H46986 Hs 31861 ESTs 31
423744 D26158 Hs 1701 ELAV (embryonic lethal, abnormal vi rπτι,Gene66, 31
432227 U28389 Hs 274122 erythrocyte membrane protein band 4 VHPJM, 31
449181 X96783 Hs 23179 synaptotagmin V C2,TM,SS 31
422274 NM 015564 Hs 114169 KIAA0416 protein LRR,LRRNT,LRRCT,TM,SS 31
424607 NM 016848 Hs 151123 neuronal She PID.SH2, 31
416898 BE219510 Hs 234074 Homo sapiens mRNA cDNA DKFZp761G02 EGF,Rhabd_glycop,TM,SS= 31
438162 NM 014618 Hs 6090 deleted in bladder cancer chromosom TM.SS 31
439892 AL043463 Hs 6755 RaP2 interacdng protein 8 RUN.SS 31
445330 R52656 Hs 21691 ESTs 7tm_1 30
451766 NM 001406 Hs 26988 ephπn-B3 Ephnn,TM,SS 30
444457 AI204146 Hs 92556 ESTs Forkjiead 30
458247 R14439 Hs 209194 ESTs 30
424616 U72671 Hs 151250 intercellular adhesion molecule 5, ιg,ICAM_N,TM,SS 30
408971 R38990 Hs 13485 ESTs 30
423940 NM 012429 Hs 277728 SEC14 (S cerevιsιae)-lιke 2 CRAL.TRIO M, 30
458124 AW005548 Hs 124590 ESTs 30
410491 AA465131 Hs 64001 Homo sapiens clone 25218 mRNA seque 30
444808 H20O19 Hs 286084 ESTs ank,ras,PH,ArfGap,HC03_co 30
437696 Z83844 Hs 5790 hypothedcal protein dJ37E16 5 Hydrolase.TM, 29
424016 AW163729 Hs 6140 hypothedcal protein MGC15730 ig.SS 29
421680 AL031186 Hs 289106 Human DNA sequence from clone CTA-9 Collagen.TM.SS 29
418055 R18516 Hs 351299 ESTs, Weakly similar to I38022 hypo ZZ.ZZ 29
444819 AI697836 Hs 148433 ESTs 29
420524 AB010575 Hs 98547 amiloπde-sensidve cation channel ASC.TM, 29
416237 H30684 Hs 159863 ESTs 29
432270 AK001008 Hs 274233 Homo sapiens cDNA FU10146 fis, do 29
405569 NM.031481* Homo sapiens solute carr mιto_carr;TM,SS 29
428950 BE311879 Hs 194673 phosphoprotein enπched in astrocyt DEO.TM, 29
426128 NM 001471 Hs 167017 gamma-aminobutync acid (GABA) B re 7tm_3,sushι,ANF receptor, 29
447758 H17302 Hs 93967 ESTs, Weakly similar to NBHUC8 deco LRR,LRRNT,LRRCT,TM,SS 29
445331 H04489 Hs 12520 Homo sapiens clone 23568, 23621, 23 PC.rep 29
431010 BE251246 Hs 248214 complexin 1 TM, 29
433065 N62902 Hs 343660 Homo sapiens PAC clone RP4-651 K2 fr ,SS 29
426845 AB025186 Hs 172740 microtubule-associated protein, RP/ EB1,CH,TM, 29
454360 L78207 Hs 54470 ATP-bindmg cassette, sub-family C ABC_tran,ABC_membrane,PRK 29
438859 AI559626 Hs 93522 Homo sapiens mRNA for KIAA1647 prot bZIP,K-box.7tm 2,EGF,cadh 29
410515 F12086 Hs 4257 ESTs PID,SH2,PID,SH2 28
434022 R18374 Hs 117956 ESTs hormone.rec,zf-C4 28
428960 AF052224 Hs 194684 bassoon (presynaptic cytomatπx pro Carta_C4,RPH3A_effector,T 28
426290 AB007918 Hs 169182 KIAA0449 protein WD40.TM, 28
417287 AI831678 Hs 285714 KIAA1599 protein C2.TM, 28
422575 AK000546 Hs 118552 hypothedcal protein FU20539 PTR2 M.SS 28
417941 AI056049 Hs 96297 ESTs Band_41,ERM 28
452707 AI093823 Hs 45070 ESTs 28
424873 AB018294 Hs 153610 KIAA0751 gene product C2,PDZ,TM, 28
408209 NM 004454 Hs 43697 ets vanant gene 5 (ets-related mol EtsJM, 28
415935 H09663 Hs 106490 ESTs PID 28
437999 AW905038 Hs 90242 ESTs ιon_trans 28
428248 AI126772 Hs 40479 ESTs 28
414001 AI610347 Hs 103812 ESTs, Moderately similar to ALU1_HU Gelsolιn,VHP,p450 28
406634 AA386235 Hs 74576 GDP dissociadon inhibitor 1 GDI.TM, 28
453439 AI572438 Hs 32976 guanine nudeodde binding protein G-gamma.TM, 28
433320 D60647 Hs 250879 ESTs, Highly similar to CTXN RAT CO nm 28
420888 AB006713 Hs 100058 dihydropynmidinase-like 4 Dihydroorotase.TM, 27
440001 AI740721 Hs 128292 ESTs 27
417622 AW298163 Hs 82318 WAS protein family, member 3 WH2.TM, 27
438626 AI198059 Hs 26370 ESTs 27
404439 ENSP00000067222* Mitochondnal 28S OLF.SS 27
448375 NM 004644 Hs 21022 adaptor-related protein complex 3, Adapdn.N.TM, 27
420989 ABM2372 Hs 323833 syntaphilm TM, 27
419651 NM 007023 Hs 91971 cAMP-regulated guanine nucleotide e cNMP_bιndιng,DEP,RasGEF,R 27
414562 AW955734 Hs 112195 ESTs, Weakly similar to 2108402A ca 27
410865 T16342 Hs 66727 ESTs, Weakly similar to T31613 hypo IRK 27
421146 AI082215 Hs 97993 ESTs, Moderately similar to SERP1 ( 27
419087 AI671245 Hs 24835 hypothedcal protein FU14594 ιg,LRR,LRRNT,LRRCT,TM,S 27
421499 AI271438 Hs 236131 homeodomain-mteracdng protein kin pkιnase,Pepddase_M1,TM 27
425014 AI251449 Hs 171939 ESTs PID.PDZ 27 448655 AL035289 Hs 21708 hypothetical protein from clone 248 TM.SS 27
424410 W79027 Hs 271762 ESTs 27
447117 AI362798 Hs 40183 ESTs 27
447478 BE618843 Hs 28144 fibronecdn type 3 and SPRY doman- fn3 SPRY.TM, 27
437645 R20728 Hs 21164 ESTs 27
433698 H24201 Hs 247423 adducin 2 (beta) AldolaseJI.TM, 27
419701 AA248999 Hs 7913 ESTs 27
410510 AW294625 Hs 64064 potassium voltage-gated channel, su cNMP binding ion traπs.PA 27
452869 AB014534 Hs 30898 KIAA0634 protein fn3,SS 27
428045 T15465 Hs 182231 thyrotropin releasing hormone ,SS 27
425218 NM 014909 Hs 155182 KIAA1036 protein TM 27
425558 AF040723 Hs 158300 hundngtin-associated protein 1 (ne TM, 26
440789 AB007857 Hs 7416 KIAA0397 gene product TBC.RUN.TM, 26
418423 NM 014732 Hs 301658 KIAA0513 gene product TM, 26
450400 AI694722 Hs 279744 ESTs lecdn.c 26
413566 AW604451 Hs 285814 sprouty (Drosophila) homolog 4 SH2,SH3,TM,SS 26
443759 BE390832 Hs 134729 FXYD domain-containing ion transpor ATP1G1.PLM_MAT8,TM,SS 26
425069 AA687465 Hs 298184 potassium voltage-gated channel, sh aldo_ket_red 26
429291 AI933057 Hs 349189 annosyl (alpha-1,3-)-glycoproteιn 26
424798 AW016523 Hs 182850 ESTs 26
447455 H38335 Hs 6750 Homo sapiens mRNA for FU00058 prot TM.SS 26
417212 AW952823 Hs 351547 NS1-bmdιng protein E2_N,E2_C,DNA_mιs_repaιr, 26
432265 BE382679 Hs 285753 SCG10-lιke-proteιπ StathminJM.SS 26
417005 C21115 Hs 26612 ESTs, Moderately similar to S23650 26
421091 W22821 Hs 351612 nbosomal protein L26 TM, 26
445472 AB006631 Hs 12784 Homo sapiens mRNA for KIAA0293 gene homeobox, CUT.TM, 26
431967 AJ243653 Hs 373498 organic cation transporter sugar_tr;TM,SS 26
439151 AW135066 Hs 283110 carbonic anhydrase X cart anhydrase.TM.SS 26
424134 AF070637 Hs 140950 hypothedcal protein DUF176.SS 26
430213 AW993446 Hs 235445 hypothetical protein FLJ21313 GRAMJM, 26
445954 AA148926 Hs 27836 hypothetical protein FU22362 fn3.TM 26
445084 H38914 Hs 250848 hypothedcal protein FU 14761 TM.SS 26
446236 NM_006293 Hs 301 TYR03 protein tyrosine kinase fn3,ιg pkinase.TM, 26
433706 AW947250 Hs 283645 ESTs PH.RhoGAP 26
423606 AB011094 Hs 129892 KIAA0522 protein PH bZIP.IQ Sec7,TM, 25
438915 AA280174 Hs 285681 Williams-Beuren syndrome chromosome 25
448923 AL034562 Hs 22584 prodynorphiπ Opiods.neuropep SS 25
408115 AB033107 Hs 42796 KIAA1281 protein 25
446772 AW294404 Hs 144515 Homo sapiens cDNA FU 11672 (is, do 25
427989 H85525 Hs 40479 gb yv88h06 r1 Soares melanocyte 2Nb TM.SS 25
435833 BE259178 Hs 41641 Bruno (Drosophila) -like 4, RNA bin πm.TM, 25
423797 BE259364 Hs 132898 fatty acid desaturase 1 heme_1,FA_desaturase,TM 25
448277 BE622827 Hs 99486 hypothetical protein FU13044 mιto_caπ,TM,SS 25
417298 AW665639 Hs 37958 ESTs 25
415577 AF257770 Hs 20930 poly(rC)-bιndιng protein 4 KH-domaιn,TM, 25
420742 U79251 Hs 99902 opioid-bmding protein/cell adhesio ιg,TM SS 25
419109 BE169157 Hs 172717 ESTs pkιnase,LRRCT,ιg,LRR LRRN 25
TABLE 28C
Pkey Umq ue number conesponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers 'D Duunnhhaamm,, eett aall ' " refers to the publication entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted
NLposition Indicates nucleotide positions of predicted exons
Pkey Ref Strand Nt.posidon
405569 6006906 Plus 99719-99873
404439 7139680 Plus 5531655585
TABLE 29A ABOUT 362 GENES UP-REGULATED IN GLIOMA COMPARED TO NON-MALIGNANT ADULT BRAIN TISSUE
Table 29A lists about 362 genes up-regulated in glioma compared to non-malignant adult bran tissue These were selected as for Table 28A, except that the ratio of "average" glioma to "average" normal brain was greater than or equal to 30, the "average" glioma level was set to the 99th percendle value amongst vaπous glioma specimens, the "average" normal adult dssue level was set to the 90th percentile value amongst vaπous non-malignant adult bran specimens, the "average" glioma value was greater than or equal to 50 units Predicted protein domains are noted
Pkey Unique Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Tide Unigene gene title
Protein Domains Predicted Protein Domains
R1 glioma vs non-malignant adult bran tissue
Pkey ExAccn Unigene ID Unigene Title Protein Domains R1
414477 U41635 Hs 76228 amplified in osteosarcoma pkmase.LRR.TM.SS 112
407241 M34516 gb Human omega light chan protein TM 109
408972 AL050100 Hs 49378 DKFZP586D0919 protein TM 70
417512 X76534 Hs 82226 glycoprotein (dansmembrane) nmb PKD.TM.SS 69
414001 AI610347 Hs 103812 ESTs Moderately similar to ALU 1 HU Gelsolm,VHP,p450 63
428847 AI954833 Hs 98881 ESTs 62
407061 X97748 gb H sapiens PTX3 gene promoter reg 54
440020 AI480204 Hs 177131 ESTs 54
408832 AW085690 Hs 63428 ESTs, Weakly similar to Z195.HUMAN 53
406837 R70292 Hs 156110 immunoglobulin kappa constant 52
407607 NM 001887 Hs 37135 ciystallin, beta B1 crystall.TM 51 435013 H91923 Hs 110024 NM 020142 Homo sapiens NADH ubiquin 51
424916 AW867440 Hs 23096 ESTs mm 51
409659 AW970843 Hs 55682 eukaryotic translation initiation f ,SS 51
432576 AW157424 Hs 165954 ESTs, Weakly similar to 138022 hypo rrm 51
406621 X57809 Hs 181125 immunoglobulin lambda locus ιg,HSP70,Ppx-GppA,TM SS 51
430418 R98852 Hs 36029 heart and neural crest denvadves HLH 51
441633 AW958544 Hs 112242 normal mucosa of esophagus specific TM SS 50
429707 W76631 Hs 211819 matπx metalloproteinase 23B ιg,Pepddase_M10,TM,SS= 50
438915 AA280174 Hs 285681 Willia s-Beuren syndrome chromosome 50
441321 H17182 Hs 7771 B-cell associated protein Band_7,TM, 50
406848 AI264844 Hs 275865 nbosomal protein S18 Rιbosomal_S13, 49
423505 AF064090 Hs 129708 tumor necrosis factor (ligand) supe TNF.TM SS 48
433848 AF095719 Hs 93764 carboxypepddase A4 Zπ_carbOpept,Propep_M14 T 48
431882 NM 001426 Hs 271977 engrailed homolog 1 homeobox.TM, 48
446295 AI355029 Hs 101660 ESTs, Weakly similar to T14171 atax LIM 48
409170 W91994 Hs 16145 ESTs rrm 48
421155 H87879 Hs 102267 lysyl oxidase Lysyl_oxιdase,Aldose_epιm 47
409202 AA236881 Hs 51043 hexosaminidase B (beta polypepdde) Glyco hydro 20,Glyco hydr 47
412115 AK001763 Hs 73239 hypothedcal protein FU10901 ,SS 47
450463 AW952018 Hs 201398 G protein coupled receptor interact C1q,Collagen,TM,SS 47
445960 AI268399 Hs 140489 ESTs, Weakly similar to UN1.HUMAN zf-C2H2,bZIP 47
406807 AA057605 Hs 180920 πbosomal protein S9 Rιbosomal_S4,S4,tRNA_ιπt_ 46
409190 AU076536 Hs 50984 sarcoma amplified sequence transmembrane4,TM,SS 46
401699 Target Exon TM, 46
408901 AK001330 Hs 48855 hypothedcal protein FU 10468 TM, 46
441669 R78195 Hs 29692 Homo sapiens cDNA FU11436 fis, do 46
406868 AA505445 Hs 300697 immunoglobulin heavy constant gamma ..TM, 46
406699 L06505 Hs 182979 πbosomal protein L12 Ribosomal L11.TM, 46
406663 U24683 immunoglobulin heavy constant mu ,SS 46
427714 AF119850 Hs 2186 eukaryotic transladon elongadon f COX8,SHMT,MIF,GST.C EF1G. 46
407260 L09095 gb Homo sapiens mRNA fragment 45
406803 H42321 Hs 163593 πbosomal protein L18a Rιbosomal_L18ae,TM, 45
430397 AI924533 Hs 105607 bicarbonate transporter related pro HC03_cotransp,TM, 45
414044 BE614194 Hs 75721 profilin 1 protilin M 45
424238 AA337401 Hs 137635 ESTs TM.SS 45
421532 AW138207 Hs 146170 hypothedcal protein FU22969 Armadillo.seg.HEAT.TM.S 44
421241 X91817 Hs 102866 transketolase-like 1 transketol3se,transket_py 44
436398 H87136 Hs 5174 nbosomal protein S17 Ribosomal.SI 7e,PolyA_pol 44
428479 Y00272 Hs 334562 cell division cycle 2, G1 to S and pkιπase,ICE_p10,ICE p20 T 44
446921 AB012113 Hs 16530 small inducible cytokine subfamily IL8.SS 43
433271 BE621697 Hs 14317 nucleolar protein family A, member , 43
406964 M21305 FGENES predicted novel secreted pro 43
432191 AA043193 Hs 273186 hypothedcal protein, clone Teletho A8C1.TM, 43
420890 AA434058 Hs 100071 6-phosphogluconolactonase Glucosaminejso TM 43
413053 AW963263 Hs 65377 ESTs, Moderately similar to KIAA139 TM, 43
406687 M31126 Hs 352054 matnx metalloproteinase 11 (strome hemopexm Pepddase M10 T 42
425157 NM 006227 Hs 283007 phospholipid transfer protein LBP.BPI.CETP.LBP.BPI.CETP 42
426386 AA748850 Hs 125830 bladder cancer overexpressed protei 42
446490 AK000706 Hs 15125 hypothetical protein FU20699 TM, 42
431750 AA514986 Hs 283705 ESTs cpn60.TCP1 42
428327 AW206236 Hs 28773 ESTs cystatm.Coprogen oxidas 42
417342 W40277 Hs 81994 glycophoπn C (Gerbich blood group) TM, 41
433688 AA628467 Hs 112572 Homo sapiens CDNA FU14130 fis do 41
433170 AB037816 Hs 8982 KIAA1395 TM, 41
423084 AU076474 Hs 123178 translocase of inner mitochondπal rrm 41
407926 AW956382 Hs 59771 ESTs TΥA.SS 41
445636 AW105401 Hs 350068 πbosomal protein 129 41
418689 AI360883 Hs 375584 hypothedcal protein FU11029 filament,GTP EFTU.EFG C,G 41
450690 AA296696 Hs 333418 FXYD doman-contaning ion transpor ATP1G1_PLM_MAT8 TM,SS 41
419092 J05581 Hs 89603 mucin 1, transmembrane SEA M SS 40
447813 AI394345 Hs 238513 hypothetical protein MGC5442 ubiquitin TM.SS 40
436419 AI948626 Hs 171356 ESTs AT hoo ATHILA 40
458147 AW752597 gb IL3-CT0214-161299-045-B06 CT0214 PMM 40
443402 U77846 Hs 356316 elasdn (supravalvular aortic steno PDZ,LIM,pkιnase 40
433435 BE545277 Hs 340959 Ts translation elongadon factor, m EF_TS,UBA 40
413595 AW235215 Hs 16145 ESTs rrm 40
412607 Z33642 Hs 74115 immunoglobulin superfamily, member ig.TM.SS 40
419913 AW270040 Hs 34455 ESTs EPH_lbdfπ3,pkιnase, 40
415209 F00183 Hs 172004 ddn 40
439310 AF086120 Hs 102793 ESTs casein_kappa.pkinase.ig n 39
421777 BE562088 Hs 108196 HSPC037 protein TM, 39
409485 S80990 Hs 252136 ficolin (collagen/fibπnogen domain Collagen.fibπnogeπ C,TM= 39
402241 Target Exon p450,TM SS 39
432716 AI762964 Hs 205180 ESTs LRRUPAR.LY6.TM 39
418140 BE613836 Hs 83551 microfibπllar associated protein 2 TM.SS 39
434214 AF119871 Hs 155860 hypothedcal protein PR02268 ,SS 39
406855 AA902829 gb ok72e06 s1 NC l_CGAP_GC4 Homo sap 39
421567 AJ272137 Hs 198265 matπx metalloproteinase 25 hemopexιn,Peptιdase_M10 T 39
403364 Target Exon SH2,Y_phosphatase 39
412339 BE151267 Hs 314466 ESTs tubulin 38
423007 AA320134 Hs 196029 Homo sapiens mRNA for KIAA1657 prot TIMP 38
427600 AW630918 Hs 179774 proteasome (prosome, macropan) act PA28_alpha.PA28.beta 38
405201 Target Exon mιto_carr,SH2,SH3,Alpha_a 38 436906 H95990 Hs 181244 major histocompadbility complex, c ιg MHC_I,TM,SS 38
407319 AI743332 Hs 257729 ESTs, Moderately similar to ALU7_HU rrm,Lιpoproteιn_2 38
400290 H18836 Hs 31608 hypothedcal protein FU20041 Cys_knot 38
430240 BE303038 Hs 236547 Homo sapiens, clone IMAGE 2905978, HEAT_PBS,TM 38
442487 AF191019 Hs 8361 hypothedcal protein, estradiol-md LRR,LRRNT,TM,SS 38
408135 AA317248 Hs 42957 methyltransferase-like 1 Methyltransf_4 TM 38
419942 U25138 Hs 93841 potassium large conductance calcium CaKB.TM.SS 38
410584 AB011112 Hs 64742 KIAA0540 protein 38
440676 NM 004987 Hs 112378 LIM and senescent cell antigen-like LIM.SS 38
406874 AW161706 Hs 180842 nbosomal protein L13 Rιbosomal_L13e,SS 37
429249 X81479 Hs 2375 egf-like module containing mucιn-l 7tm 2,EGF,GPS,S_locusjly 37
430799 C19035 Hs 164259 ESTs FKBPJPR 37
453099 H62087 Hs 31659 thyroid hormone receptor-associated WD40JM, 37
421794 X86096 Hs 108371 E2F transcnpdon factor 4, p107/p1 E2F.TDP,KOW,Rιbosomal.L14 37
444795 A1193356 Hs 160316 ESTs Tropomyosιn,ACOX 37
443834 AI741510 Hs 173548 ESTs CUB,MAM,F5_F8 type.C 37
429731 AK001592 Hs 212172 beta-carotene 15,15'-dιoxygenase RPE65.SS 37
426433 L38969 Hs 169875 thrombospondin 3 TSPN,tsp.3,EGF,toxιn,TM 37
426395 BE151985 Hs 355669 hypothedcal protein FU23316 pkmase 37
406704 M21665 Hs 929 myosin, heavy polypepdde 7, cardia myosιn_head,IQ,Myosιn_ta 37
447860 AF193807 Hs 131835 Rhesus blood group, B glycoprotein Ammonιum_transp,FecCD,TM= 37
430281 AI878842 Hs 237924 CGI-69 protein mιto_carr,homeot)ox.TM,S 37
448360 AL117560 Hs 306352 Homo sapiens mRNA cDNA DKFZp566P23 37
446057 AI420227 Hs 366053 Trp-p8 transient receptor potendal 37
432078 BE314877 Hs 24553 hypothedcal protein FU12541 simil TM.SS 37
406854 AA613705 Hs 252259 nbosomal protein S3 KH-doman,Rιbosomal_S3_C, 37
422532 AL008726 Hs 118126 protecdve protein for beta-galacto senne_carbpeptGalP_UDP_ 37
428171 AA489323 Hs 182825 πbosomal protein L35 Rιbosomal_L29, 36
442285 W28729 Hs 356072 uncharactenzed hypothalamus protei 36
411281 BE392792 Hs 4786 Homo sapiens cDNA FU22849 fis, cl cadhenn 36
457657 AW411509 Hs 352567 hypothedcal protein PR02121 UQ_con,TM 36
414624 BE389320 Hs 23628 3 beta-hydroxy-delta 5-C27-steroιd 36
451564 AU076698 Hs 132760 hypothetical protein MGC15729 sugar r.Condensadoπ TM= 36
445411 AL137255 Hs 12646 hypothedcal protein FU22693 hormone rec.zf-CCCH.TM, 36
400785 C11000861 gι!9938016|reflNP_064687 TM.SS 36
413343 BE392026 Hs 334346 hypothedcal protein MGC13045 TM, 36
427380 NM 005534 Hs 177559 interferon gamma receptor 2 (interf fn3,TM SS 36
427818 AW511222 Hs 193765 ESTs 36
449957 D31365 Hs 24220 hypothedcal protein TM, 36
451529 AI917901 Hs 208641 ESTs actin 36
446528 AU076640 Hs 15243 nucleolar protein 1 (120kD) Nol1_Nop2_Sun TM 36
431659 AA031875 Hs 266940 t-complex-associated-tesds-express Tctex-1,TM, 36
433350 BE563152 Hs 10362 Homo sapiens cDNA FLJ20944 fis, cl zf-C3HC4,SPRY 36
412896 AW804157 Hs 375570 major histocompadbility complex, c ιg,MHC_ll_beta,TM,SS 36
441748 R14439 Hs 209194 ESTs 36
406853 AA614553 Hs 252259 hypothedcal protein FU23059 KH-domaιn,Rιbosomal_S3_C, 35
457464 AW972234 Hs 126680 ESTs 35
429619 AL120751 Hs 211568 eukaryodc translation iπidadon f 35
423309 BE006775 Hs 126782 sushi-repeat protein sushι,HYR,SS 35
438682 AA354489 Hs 375594 EBP50 PDZ teractor of 64 kD 35
453022 AA031499 Hs 118489 ESTs Amιno_oxιdase 35
434042 AI589941 Hs 8254 Homo sapiens. Similar to tumor diff 35
424867 AI024860 Hs 153591 Not56 (D melanogaster)-lιke protei TM SS 35
417298 AW665639 Hs 37958 ESTs 35
403943 C5000355 gι|4503225|ref|NP_000765 1 35
429497 AB028953 Hs 204121 KIAA1030 protein fn3,TM, 35
426613 U96132 Hs 171280 hydroxyacyl-Coenzyme A dehydrogenas adh_short,TM,SS 35
428343 AL043021 Hs 12705 ESTs WD40.SS 35
456376 AA663904 Hs 89862 TNFRSF1 A-associated via death doma death TM, 35
400348 AJ251708 Hs 352588 Target 35
404854 Target Exon ,SS 35
427930 AA417696 Hs 372121 ESTs 35
453143 AA382234 Hs 356289 protein tyrosine phosphatase, recep serpin.SS 35
406806 AW088535 Hs 350108 nbosomal protein, large P0 TM, 35
406793 AW264291 Hs 5662 guanine nucleotide binding protein WD40 TM, 35
414525 C14904 Hs 45184 Homo sapiens cDNA FU 12284 fis, do 35
419950 AK001645 Hs 93871 hypothetical protein FU 10783 Glyco_hydro_47,TM,SS 35
404243 NM.006778 Homo sapiens πng finger Z.-C3HC4 zf-B_box,TM SS 34
424611 NM 001421 Hs 151139 E74-lιke factor 4 (ets domain trans Ets.SS 34
432831 AI821702 Hs 115959 ESTs, Weakly similar to I38022 hypo 34
413943 AW294416 Hs 144687 Homo sapiens cDNA FLJ12981 fis, do TM, 34
418558 AW082266 Hs 86131 Fas (TNFRSF6)-assocιated via death death.DED.SS 34
408930 AA146721 Hs 334686 hypothetical protein FU21588 CUE.TM 34
403246 Target Exon HMG_box,SS 34
416330 AU077101 Hs 79222 galactosidase, beta 1 Glyco_hydro_35,TM SS 34
404864 NM.025204* Homo sapiens hypothedca 34
441384 AA447849 Hs 288660 Homo sapiens cDNA FU22182 fis, cl 7tm_3 34
430284 AI693534 Hs 293196 ESTs 34
433669 AL047879 Hs 194251 ESTs. Weakly similar to ALU2_HUMAN RNA_pol_L,RNA_pol_L,R3sGA 34
456050 R79445 Hs 76230 nbosomal protein S10 S10_plecdn TM 34
422311 AF073515 Hs 114948 cytokine receptor-like factor 1 fn3,TM, 34
408909 AW502034 Hs 287379 ESTs. Weakly similar to T26022 hypo 34
428028 U52112 Hs 182018 ιnterteukιn-1 receptor-associated k death.pkinase.TM, 34 424213 BE390125 Hs 143187 hypothedcal protein DEAD,helicase_C,TM 34
416432 BE391767 Hs 79322 glutaminyl-tRNA synthetase 34 400233 Eos Control Rιbosomal_S9, 34
403252 Target Exon TM.SS 34
409433 AA074382 Hs 135255 ADAMTS14 34
426053 U68105 Hs 172182 poly(A)-bιndιng protein, cytoplasmi rrm.PABP.TM 34
448222 AI648587 Hs 20725 Mov10 (Moloney leukemia virus 10, m TM, 34
432982 AA531058 Hs 182248 truncated calcium binding protein OP ZZ.TM, 34
453914 NM_000507 Hs 574 fructose-1,6-bιsphosphatase 1 FBPase.TM, 34
444626 AA320893 Hs 117062 hypothedcal protein FLJ14497 pyr_redox,TM,SS 34
427751 AF000152 Hs 355816 consen ed gene amplified in osteosa NIFJM, 34
416971 R34657 Hs 80658 uncoupling protein 2 (mitochondrial mito.carr.TM, 34
428046 AW812795 Hs 337534 ESTs, Moderately similar to I38022 ank 34
456575 AW063659 Hs 191649 ESTs Myosiπ.tail 34
407366 AF026942 Hs 17518 gb Homo sapiens cιg33 mRNA, partial IBR 34
414738 L24038 Hs 77183 v-raf muπne sarcoma 3611 viral one pkιnase,DAG_PE-bιnd,RBD,T 34
456356 M74715 Hs 89560 iduronidase, alpha-L- Glyco_hydro_39,SS 33
429668 AA626142 Hs 179991 ESTs, Weakly similar to S28942 prot 33
404913 NM_024408* Homo sapiens Notch (Dros EGF,ank,notch,metalthιo,E 33
426059 BE292842 Hs 166120 interferon regulatory factor 7 IRF.SS 33
451619 AA018854 Hs 353196 glutathione peroxidase 3 (plasma) PH.SS 33
410225 AW608964 Hs 12030 ESTs 33
402534 Target Exon 33
433750 H15448 Hs 31330 Homo sapiens clone HQ0319 GLFV dehydrog,GLFV_dehydr 33
421712 AK000140 Hs 107139 hypothetical protein TM.SS 33
433333 AI016521 Hs 71816 v-akt munne thymoma viral oncogene pkιnase,PH,pkιnase_C 33
424915 R42755 Hs 23096 ESTs rnn 33
408494 AA554714 Hs 187578 Homo sapiens cONA FU 11639 fis, do 33
445084 H38914 Hs 250848 hypothedcal protein FU 14761 TM.SS 33
446478 AI950021 Hs 370306 ESTs TM, 33
425274 BE281191 Hs 155462 minichromosome mantenance deficieπ MCM.TM, 33
456655 AI376736 Hs 111779 secreted protein, acidic, cysteine- kazal.SS 33
438912 AF085843 gb Homo sapiens full length insert 33
428396 U70539 Hs 184161 exostoses (multiple) 1 Exostosin.TM.SS 33
437546 AW074836 Hs 173984 T-box 1 T-box,WD40,TM, 33
410693 BE044206 gb ho40c08x1 Soares_NFL_T.GBC_S1 H C1q Collagen.cystati 33
414961 U27266 Hs 927 myosin-bmding protein H fn3.ιg,TM, 33
422766 AA334108 Hs 159572 heparan sulfate (glucosamine) 3-O-s 33
426120 AA325243 Hs 166887 copine I C2,rrm,TM, 33
452383 T70900 Hs 27189 ESTs zf-C2H2,PRK 33
456799 AC004923 Hs 135187 uπc93 (C elegans) homolog B TM, 33
409227 AA806165 Hs 130323 Homo sapiens, clone IMAGE 3960432, NA.NA 33
432659 AA281633 Hs 278586 KIAA1108 protein TBC M, 33
448997 AA130390 Hs 25549 hypothedcal protein FU20898 TM.SS 33
446990 AI354717 Hs 223908 ESTs transmembraπe4 33
437259 AI377755 Hs 120695 ESTs MHC_ll_alpha,ιg 33
423461 AB020527 Hs 128827 solute earner family 17 (sodium ph sugar.tπTM, 33
421563 NM 006433 Hs 105806 graπulysm ,SS 33
453804 AA300204 Hs 35276 KIAA0852 protein TM, 33
428810 AF068236 Hs 193788 mtπc oxide synthase 2A (inducible NAD.bmding.fiavodoxiπ.FA 33
453933 AI452933 Hs 65377 ESTs EF.TS.UBAtransmembr 33
449267 AI638640 Hs 220624 ESTs 33
418165 R45959 Hs 6637 ESTs mιto_carr 33
446673 NM.016361 Hs 15871 LPAP for lysophosphatidic acid phos acιd_phosphat,TM,SS 33
402475 ubiquitin specific protease 18 32
404233 Target Exon HIT 32
406655 M21533 Hs 277477 major histocompadbility complex, c ιg,MHC_l,TM,SS 32
414556 AW975063 Hs 343443 πbosomal protein L36 Rιbosomal_L36e, 32
450191 AW137243 Hs 248074 ESTs homeobox.TM, 32
435906 AI686379 Hs 110796 SAR1 protein arf.ras.TM, 32
412540 C18341 Hs 73999 thyroid hormone receptor mteractor SH3,FCH,SS 32
422562 AI962060 Hs 118397 AE-biπdmg protein 1 Zn_carbOpept,F5_F8_type_C 32
431051 AA491143 Hs 283374 ESTs. Weakly similar to CA15 HUMAN TM, 32
407984 AW134708 Hs 243569 ESTs 32
441494 AW452344 Hs 129977 ESTs 32
423114 AU076497 Hs 1614 cholmergic receptor, ntcodnic, al Neur_chan_LBD,Neur_chan_m 32
419833 AA251131 Hs 220697 ESTs WHEP-TRS.tRNA-syntJb.non 32
419036 T80967 Hs 372603 gb yd23f12 s1 Soares fetal liver sp 32
431222 X56777 Hs 273790 zona pellucida glycoprotein 3A (see zona_pellucιda,TM,SS 32
453094 AA740928 Hs 27356 ESTs 32
426989 AI815206 Hs 367644 ESTs BAG.ubiquidn 32
445033 AV652402 Hs 72901 cyclin-depeπdenl kinase inhibitor 2 ank, 32
446272 BE268912 Hs 14601 hematopoietic cell-specific Lyn sub SH3.HS1 rep.TM, 32
438930 AW843633 Hs 343261 hypothedcal protein AL110115 HLH 32
438183 BE263252 Hs 6101 hypothedcal protein MGC3178 thiored.TM, 32
421310 AW630087 Hs 103315 tnnucleodde repeat containing 1 PHD 32
409293 R02673 Hs 110156 ESTs 32
407115 AA084921 Hs 76230 πbosomal protein S10 S10_plecdn,TM, 32
401174 Target Exon transmembrane4,EF_TS,UBA 32
400217 Eos Control ras.SS 32
408676 AI815189 Hs 57475 sex comb on midleg homolog 1 32
418245 AA088767 Hs 83883 transmembrane, prostate androgen in TM.SS 32
403694 Target Exon UDPGT 32 414265 BE410411 Hs 75864 endoplasmic redculum glycoprotein 32
451118 AI862096 Hs 60640 ESTs EGF,vwc,TIL,SS 32
422624 BE616678 Hs 76152 KDEL (Lys-Asp-Glu-Leu) endoplasmic ERJumen.recept 32
437388 AL359586 Hs 14478 Homo sapiens mRNA, cDNA DKFZp762H18 32
429150 AF120103 Hs 197366 smoothened (Drosophila) homolog COX8,SHMT,MIF,GST.C,EF1G. 32
430379 AF134149 Hs 240395 potassium channel, subfamily K, mem ion trans.T SS 32
434956 8E266566 Hs4288 hypothedcal protein DKFZp434K046 Cullm M, 32
422166 W72424 Hs 112405 S100 calcium-binding protein A9 (ca efhand,S_100,TM, 32
452493 AI904031 Hs 106826 KIAA1696 protein PHD,Myc-LZ,DC1 ,AT_hook,TM 32
413100 BE065208 gb RC1-8T0314-310300-015-b09 BT0314 32
420764 BE250676 Hs 19928 hypothetical protein SP329 F-box,TM, 32
421680 AL031186 Hs 289106 Human DNA sequence from clone CTA-9 Collagen,TM,SS 32
406738 AA587983 gb nj30b09 s1 NCI_CGAP_AA1 Homo sap TIM.Ribosomal S5,TM,SS= 3 1
434288 AW189075 Hs 116265 fibnllιn3 EGF,granulιn,TB,EB,TIL,TM 3 1
438264 T86773 Hs 6133 calpain 5 Calpaιn_lll,Pepddase.C2, 3 1
436819 AA731746 Hs 120232 ESTs nm 3 1
459298 R86701 gb ym86d09 r! Soares adult bran N2 TM, 31
452127 BE562126 Hs 28081 eukaryotic translation initiation f rnn,7tm_1,SNF,TM, 3 1
422305 AI928242 Hs 293438 ESTs, Highly similar to AF198488 1 3 1
414393 AA146855 gb zo41h10 r1 Stratagene endothelia 3 1
423369 BE219099 Hs 279513 ESTs 3 1
429457 BE243065 Hs 202955 hypothedcal protein FU 20507 Cys-protease-3C,TM, 31
409124 AW292809 Hs 50727 N-acetylglucosaminidase, alpha- (Sa TM.SS 3 1
429615 AF258627 Hs 211562 ATP-bindmg cassette, sub-family A ABC tran,TM,SS 3 1
445519 AI635202 Hs 170132 hypothetical protein FLJ22494 TM, 3 1
410007 AW950887 Hs 57813 zinc ribbon domain containing, 1 TFIISJM, 3 1
407228 M2S079 Hs 155376 hemoglobin, beta globiπ.TM, 31
411573 AB029000 Hs 70823 KIAA1077 protein Sulfatase.TM, 3 1
406654 M90686 Hs 73885 HLA-G histocompadbility andgen, c ιg,MHCJ,TM,SS 3 1
435072 AW592176 Hs 116932 ESTs zf-RanBP,MDM2 3 1
456642 AW451623 Hs 109752 putative c-Myc-respoπsive ,SS 3 1
445457 AF168793 Hs 12743 carnitine O-octanoyltransferase Carn.acyltransf M, 31
448389 AW188950 Hs 345838 ESTs 20G-Fell_Oxy,rrm,SH3 ras 3 1
458248 BE407379 Hs 108082 ESTs, Weakly similar to T31636 hypo C1q,Collagen,TM,SS 3 1
451310 AW250651 Hs 26213 Human DNA sequence from clone RP3-4 TM, 3 1
414688 AI750246 Hs 76901 for protein disulfide isomerase-rel thiored.SS 3 1
428797 AA496205 Hs 193700 Homo sapiens mRNA, cDNA DKFZp586l03 LIM,Ran_BP1,GRIP,TPR,pro_ 31
425067 BE223071 Hs 169142 ESTs 3 1
410639 BE269047 Hs 65234 hypothedcal protein FU20596 DEAD.helicase C.PRK.AIP3, 3 1
413011 AW068115 Hs 821 biglycan LRR.LRRNT.SS 3 1
421502 AF111856 Hs 105039 solute earner family 34 (sodium ph Rιbosomal_L20,Na_Pι_cotra 3 1
447164 AF026941 Hs 17518 vipmn, similar to inflammatory r MoaA.NifB.PqqE.TM 3 1
414907 X90725 Hs 77597 polo (Drosophιa)-lιke kinase Ribosomal L37ae,pkιnase,P 3 1
418613 AA744529 Hs 86575 mitogen-acdvated protein kinase ki pkιnase,CNH,TM, 3 1
406734 AI565616 gb to16h12 x1 NCI_CGAP_Ut2 Homo sap 3 1
410188 AL096739 Hs 107260 hypothedcal protein DKFZp586H0623 Ricin B lecdn.Glycos tra 3 1
437959 AI472068 Hs 375604 KIAA1856 protein elF5_elF2B,W2,TM, 31
406764 AA429825 Hs 343443 nbosomal protein L36 Rιbosomal_L36e, 3 1
406637 U14966 Hs 180946 πbosomal protein L5 Ribosomal _L18p, 3 1
451080 H41082 Hs 271783 ESTs 3 1
414875 H42679 Hs 77522 major histocompadbility complex, c ig.MHC II alpha,TM,SS 3 1
416365 U15131 Hs 79265 suppression of tumongenicity 5 DENN dDENN,uDENN,TM,SS= 3 1
400261 Eos Control ig.MHC.II.beta M SS 3 1
412270 AC005262 Hs 73797 guanine nudeodde binding protein G-alpha arf.TM, 3 1
456843 BE301883 Hs 152707 glioblastoma amplified sequence 3 1
443071 AL080021 Hs 8986 complement component 1, q subcompon C1q,Collageπ,SS 3 1
426196 BE272095 Hs 167791 reticulocalbin 1, EF-hand calcium b efhand SS 3 1
424010 AL080188 Hs 137556 Homo sapiens mRNA, cDNA DKFZp434A13 cadhenn M.SS 3 1
439975 AW328081 HS 6817 inosme tπphosphatase (nucleoside Ham1p.like.TM, 3 1
450761 R75930 Hs 174838 Homo sapiens cDNA FLJ14192 fis, do 3 1
418322 AA284166 Hs 84113 cyclin-dependent kinase inhibitor 3 Y_phosphatase,DSPc,TM,S 3 1
432396 AW295956 Hs 11900 hypothedcal protein FU14972 Xlιnk,zf-CCCH,G-patch,non 3 1
407904 W44735 Hs 107260 Homo sapiens cDNA FLJ21278 fis, cl 3 1
452500 AW373011 Hs 54558 hypothedcal protein FU22222 3 1
432171 AI202503 Hs 343661 ESTs, Weakly similar to ALUB.HUMAN WD40 3 1
416768 AA363733 Hs 1032 regeneradng islet-denved 1 alpha lecdπ_c,TM,SS 31
442492 AA528489 Hs 234518 nbosomal protein L23 Ribosomal L14, 30
421210 U80016 Hs 102598 mucosal vascular addressin cell adh TM.SS 30
439429 AF150286 gb AF150286 Human mRNA from cd34 st RA,Band_7,M80AT 30
447463 AW378685 Hs 18625 Mitochondπal Acyl-CoA Thioesterase Acyl-CoA hydro.TM, 30
448352 AA337951 Hs 20991 SET domain, bifurcated 1 AhpC-TSA,SET,MBD,TM,SS= 30
428291 AA534009 Hs 183487 interferon sdmulated gene (20kD) 30
445669 AI570830 Hs 174870 ESTs 30
452862 AW378065 Hs 8687 ADAMTS2 (a dismtegπn-like and me Pep M12B_propep tsp_1,Rep 30
430069 AI219293 Hs 293660 Homo sapiens, clone IMAGE 3535476, SPRY,zf-B_box,zf-C3HC4,TM 30
451028 AA021258 Hs 123073 ESTs 30
446021 BE389213 Hs 286 nbosomal protem L4 Ribosomal ATM, 30
434652 AF148713 Hs 125830 bladder cancer overexpressed protei WD40.DUF6, 30
425829 AL133079 Hs 134126 crystallin, gamma S ctystall M, 30
424909 S78187 Hs 153752 cell division cycle 25B Rhodanese.SS 30
423579 NM 004121 Hs 1675 gamma-gluta yltraπsferase-like acd G_glu.transpepLTM,SS 30
444652 BE513613 Hs 11538 acdn related protein 2/3 complex, WD40JM, 30
441283 AA927670 Hs 131704 ESTs CUB,MAM,F5.F8_type.C 30 437415 AL137400 Hs 306456 pre-mRNA processing factor 18 Band.41,hormone2,Prp18,TM 30
444542 AI161293 Hs 280380 aminopepddase NAD binding.flavodoxin.FA 30
442426 AI373062 Hs 332938 hypothetical protein MGC5370 zf RanBP,MDM2 30
447910 AL137679 Hs 20000 Homo sapiens mRNA, cDNA DKFZp434D24 Exonuclease.SS 30
426858 NM.004182 Hs 172791 ubiquitously-expressed transcπpt DUF232.SS 30
445417 AK001058 Hs 12680 a dismtegπn-like and metalloprote tsp_1,Reprolysin,Pep M12B 30
430482 AF131810 Hs 241545 hypothedcal protein TM.SS 30
427661 AA410292 Hs 104761 ESTs wnt 30
451876 T63141 gb yb99a1 s1 Stratagene lung (9372 SH3 30
453862 AL137493 Hs 35945 Homo sapiens mRNA, cDNA DKFZp434B12 ig.TM, 30
452965 AI904779 Hs 247525 Human DNA sequence from clone RP11- C2.PHD.RPH3A effector.zf- 30
441455 AJ271671 Hs 7854 zmc/iron regulated transporter-lik Zip.TM.SS 30
452600 AI910842 Hs 103381 ESTs Exo_endo_phos 30
450775 AA902384 Hs 73853 bone morphogenedc protein 2 TGFb_propeptιde,TGF-beta 30
417634 W27202 Hs 82327 glutathione synthetase GSH.synthase.TM, 30
415152 W22644 Hs 278712 Homo sapiens cDNA FU11074 fis, do 30
410093 AW589558 Hs 299883 ESTs, Weakly similar to KIAA0970 pr 30
412404 AW075995 Hs 86228 TRIAD3 protein 30
443466 BE243123 Hs 321045 IKK-related kinase epsilon, inducib pkmase.RIOUM, 30
TABLE 29B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
458147 1030220 1 AW848781 AW848490 AW849062 AW752597 AW752699
406855 0 0 AA902829
400233 11259 1 BC004324 NM 001020 BC007977 M60854 BM050628 BG829809 BE385504 BG744451 BI826914 E
BE255792 BI194169 BI668218 BI194376 BG716213 BG714408 BE392513 AV722219 AW328077 BM424171 BI828267 AW958606 BG831252
BE392943 BE394033 BI858915 BI668334 8E621019 BG706995 BE791985 BF967484 BI193635 BG761859 BM466537 BG747165 BG827488 AI133550
BM011511 BI227282 BG489212 BG478388 BE727789 BI160880 BG831707 BG324692 BM470427 BI083889 BG831605 BG754114 BG420536
BF308210 BE384213 BG832271 BG828032 BG481641 BF205675 BE899041 BE271558 BI193807 BI159866 BG473786 BG397178 BI19442881117210
BG768326 BG759507 BF975645 BF343657 BM020598 BG831082 BG829943 BG829501 BF306557 BE562511 BM050145 BM017978 BI193934
BI160764 BI160371 BG754991 BF973348 BF663234 BF032537 BE388168 BM009051 BI192794 BG831002 BG830459 BG764737 BG761808
BG481705 BG104314 BM464565 BI261500 BG831857 BG8316848G829852 BG765030 BG760419 BG760268 BG749762 BG480900 BG419627
BG248771 BF975542 BM042233 BI161149 BG831302 BG830033 BG829626 BM050064 BI193014 BI161360 BG822729 BG110091 BG106500
BI258369 BG831982 BM458301 BM019513 BI161350 BI114178 BG481969 BG474870 BF974048 BF971122 BE741405 BE395269 BG832027
BG831469 BG490895 BM413638 BG943529 BG831012 BG829471 BG686284 BG337575 BG336551 BF206677 BI258301 BI160946 BG105893
BF183072 BM459542 BI193881 BG832043 BG831323 BI194545 BI160968 BG755930 BG706018 BE743865 BM465145 BG831227 BG774290
BF683451 BE907161 BM045391 BI194396 BI161269 BG747091 BG546643 BF984863 BI160206 BI226402 BI226336 AW328236 BG339458 BF972634
BE909808 BI160988 BM60251 BG828764 BG826860 BG758360 BF568228 BI818282 BI457127 BG831491 BG759864 AI830010 BF568381 BE907238
BI161172 BI116773 BG827153 BG825088 BG335419 BG 109404 AI929068 BE906354 BE408564 BM045000 BG339617 BG282794 BG335767
BE907263 BF568921 BG829961 BG479305 BG260397 AI922228 BE301975 AW516055 BG480919 BG480626 AW196817 BG336261 BE906157
BE395717 BE391427 BI192954 BG829757 BG476379 BE301536 BE394727 BE257695 BE905344 AI433577 BE894416 BE886992 BE409223
BF034756 BE904077 BG830886 BE909153 BE907998 BE395767 AI871751 BE744523 BI192663 BG831669 AI000225 BE743836 BE272515 AA628078
BM463802 BE393375 BE393033 AW170187 BE730961 BE395410 BE744572 BE392297 BE391448 BE390780 BE388821 BE258477 BE905970
BE901567 BE898833 BE880326 BF726889 BE910504 BE390753 BE390131 AA650542 BE744156 BE394125 BE742207 BE395265 BE392942
BE894336 BE378222 BE906926 BE904650 BE393704 BE620999 BE515162 BE378753 BE272370 BE907458 BE612801 BE392484 BE907636
BE907353 BE910491 BE909796 BE905331 AW248173 AI683576 BE908826 BE620180 BF037570 BE908312 BE615015 BE256977 BE746875
BE394133 BE391478 BE910068 BE907185 BE742109 AA995746 BE561195 BE908825 BE906472 BE906509 BE906017 BE910442 BE514657
BI261969 BE741707 BE392216 BM042793 BF570283 BI262119 BE395707 BE378298 AW327827 BE394422 BF569178 BE263240 AI700512
BG830290 BF569308 BF569156 BI194587 BE390831 BG745096 AI681675 BE395674 AA136372 BE279892 AA442822 BE384898 AA313519 AI878866
AA305904 F33366 BE394852 F29153 F33618 AI133637 AA300009 F34063 F29455 AU099691 AI905085 AI906656 AA343249 BE388691 AW404280
AA379888 F29022 BF089981 F31013 F24305
438912 4071J AF085843 R70623 R70523 410693 1054267 BE044206 AW797320 BE161676 AW797356AW797352 413100 1490226 1 BE065224 BE065168 BE065313 BE065208 406738 0_0 AA587983 459298 90831 2 AL157655 BF802216 R86701 BF802224 R84600 BF356151 BG982935 414393 15833.3 AL532972 BI092731 AI765546 AA393801 AI129669 AI393538 AW519008 AI432598 AW295856 AI650941 AI470541 AL550388 AA146856 AI074762
BE895187 AA393867 BI052082
406734 0.0 AI565616 AI190141 400261 23110.1 BC006097 X03066 NM.002120 M26040 AW469119 AW469127 AI299772 AW518149 AI144456 AW628070 AI629032 AI358810 AI880433 AI440472
AI357070 AI865365 AW014799 AI767973 AW518041 AA909398 AW768606
439429 452694 1 AF150286 AV739062 AA835857 451876 2328579.1 T63141 AI821021 BF370092 BF370127 BF370060 T62998
TABLE 29C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publicadon endtled The DNA sequence of human chromosome 22* Dunham, et al (1999) Nature 402489-495 Strand Indicates DNA strand from which exons were predicted
Nt.posidon Indicates nudeodde posidons of predicted exons
Pkey Ref Strand Nt_posιtιon
401699 3176654 Minus 33285-34084
402241 7690131 Minus 125073-125206,130996-131125
403364 8571785 Plus 120351-120465
405201 7230116 Plus 36934-37314
400785 8131682 Plus 43113-43967
403943 7711864 Plus 100742-100904,101322-101503
404854 7143420 Plus 14260-14537 404243 5672609 Plus 74695-75123
403246 7637831 Minus 143547-143654,143741-143900
404864 5263010 Plus 94495-94661.95055-95195,97396-97506,9760
403252 7677983 Plus 102214-102692
404913 7341740 Plus 97717-97976
402534 9801061 Plus 58989-59457
402475 7547191 Plus 65363-65725
404233 8218045 Minus 84791-85123
401174 9438414 Minus 132847-133917
403694 7107765 Plus 142925-143080,165505-166186,167486-16763
TABLE 30A ABOUT 282 GENES UP-REGULATED IN GLIOMA COMPARED TO NON-MALIGNANT ADULT BRAIN TISSUES THAT ARE LIKELY TO ENCODE EXTRACELLULAR OR CELL-SURFACE PROTEINS
Table 30A lists about 282 genes up-regulated in glioma compared to non-malignant adult bran dssues that are likely to encode extracellular or cell-surface proteins These were selected as for Table 28A, except that the rado of "average" glioma to "average" normal adult dssues was greater than or equal to 40, the "average" glioma level was set to the 99th percendle value amongst vaπous glioma specimens, the "average" noπnal adult bran dssue level was set to the 75th percendle value amongst vaπous non-malignant bran dssues, the 'average' glioma value was greater than or equal to 50 units (this selects for the most abundant of the up-regulated genes), and the predicted protein contained a structural domain that is indicative of extracellular localization (e g tg, fn3, efg, 7tm domains, signal sequences, transmembrane domains) Predicted protein domans are noted
Pkey Unique Eos probese it idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dtle
Protein Domains Predicted Protein Domans
R1 glioma vs non-malignant adult bran dssues likely to encode extracellular or cell-surface proteins
Pkey Accession UniGene ID Unigene Tide Protein Domains R1
406868 AA505445 Hs 300697 immunoglobulin heavy constant gamma ιg,TM, 376
407241 M34516 gb Human omega light chain protein TM, 227
414477 U41635 Hs 76228 amplified in osteosarcoma pkιnase,LRRJM,SS 227
417512 X76534 Hs 82226 glycoprotein (transmembrane) nmb PKD,TM,SS 154
406803 H42321 Hs 163593 πbosomal protein L18a Rιbosomal_L18ae,TM, 142
429707 W76631 Hs 211819 matπx metalloproteinase 23B ig Pepddase M10,TM,SS= 128
419092 J05581 Hs 89603 mucin 1, transmembrane SEA,TM,SS 128
414738 L24038 Hs 77183 v-raf munne sarcoma 3611 viral one pkιnase,DAG_PE-bιnd,RBD;T 124
441384 AA447849 Hs 288660 Homo sapiens cDNA. FU22182 fis, cl 7tm 3,none 11 6
406621 X57809 Hs 181125 immunoglobulin lambda locus ιg,HSP70,Ppx-GppATM,SS 11 0
410584 AB011112 Hs 64742 KIAA0540 protein none 11 0
426395 BE151985 Hs 355669 hypothedcal protein FU23316 pkinase.none 107
425184 BE278288 Hs 155048 Lutheran blood group (Auberger b an ιg,TM,SS 107
430379 AF134149 Hs 240395 potassium channel, subfamily K, mem ion trans.TM.SS 10 3
408972 AL050100 Hs 49378 DKFZP586D0919 protein TM, 99
446921 AB012113 Hs 16530 small inducible cytokine subfamily IL8.SS 99
452862 AW378065 Hs 8687 ADAMTS2 (a disintegπn-like and me Pep_M12B_propep,tsp_1 ,Rep 97
418101 AL047476 Hs 296310 gap juncdon protein, alpha 4, 37kD connexιn,TM,SS 85
400290 H18836 Hs 31608 hypothetical protein FU20041 Cys knot 84
401699 Target Exon TM, 81
423309 BE006775 Hs 126782 sushi-repeat protein sushι,HYR,SS 81
427600 AW630918 Hs 179774 proteasome (prosome, macropan) act PA28 alpha.PA28.beta, 79
436906 H95990 Hs 181244 major histocompadbility complex, c ig MHC_I,TM,SS 78
425335 BE394327 Hs 296267 follistadn like 1 efhand,kazal,arf,r3s,7tm 77
413011 AW068115 Hs 821 biglycan LRR,LRRNT,SS 77
446295 AI355029 Hs 101660 ESTs, Weakly similar to T14171 atax LIM 77
436398 H87136 Hs 5174 πbosomal protein S17 Rιbosomal_S17e,PolyA_pol, 76
435013 H91923 Hs 110024 NM_020142 Homo sapiens NAOH ubiquin none 74
431809 AI623488 Hs 333488 Homo sapiens, clone IMAGE 3603998, TM.SS 74
424608 X80695 Hs 151134 oxidase (cytochrome c) assembly 1-1 60KO.IMP M, 73
438560 AA481690 Hs 300697 immunoglobulin heavy constant gamma 19 73
429297 X82494 Hs 198862 fibulin 2 EGF,ANATO,TIL,spιdertoxιn 73
450463 AW952018 Hs 201398 G protein coupled receptor interact C1q Cdlagen.TM.SS 72
417342 W40277 Hs 81994 glycophoπn C (Gerbich blood group) TM, 72
414688 AI750246 Hs 76901 for protein disulfide isomerase-rel thiored.SS 72
414044 BE614194 Hs 75721 profilin 1 profilm M, 71
404864 NM_025204* Homo sapiens hypothetica , 71
452127 BE562126 Hs 28081 eukaryotic translation initiation f rrm,7tm 1,SNF,TM, 70
412115 AK0O1763 Hs 73239 hypothedcal protein FU10901 ,SS 70
409826 AW501112 Hs 353013 hypothetical protein FU23412 none 69
434343 AW956705 Hs 3804 DKFZP564C1940 protein Idl recept a,TM, 69
427714 AF119850 Hs 2186 eukaryotic translation elongation f COX8,SHMT,MIF,GST_C,EF1 G_ 69
437259 AI377755 Hs 120695 ESTs MHC II alpha,ιg,none 69
429212 NM 001504 Hs 198252 G protein-coupled receptor 9 7tm_1,TM, 68
448988 Y09763 Hs 22785 gamma-aminobutync acid (GABA) A re Neur chan LBD.Neur chan m 68
423505 AF064090 Hs 129708 tumor necrosis factor (ligand) supe TNFJM.SS 68
413053 AW963263 Hs 65377 ESTs, Moderately similar to KIAA139 TM, 67
430542 AI557486 Hs 119122 nbosomal protein L13a Rιbosomal_L13,LACT,arf,ra 67
435906 AI686379 Hs 110796 SAR1 protein arf.ras.TM, 66
429307 AU076592 Hs 198951 jun B proto-oncogene bZIP.TM, 64
437388 AL359586 Hs 14478 Homo sapiens mRNA, cDNA DKFZp762H18 none 64
415714 NM 002290 Hs 78672 laminin, alpha 4 lamιnιn_EGF,lamιnιn_G,Tro 63
406733 AA976565 Hs 297753 vimendn filament,bZIP,Apdιpoprot 63
411296 BE207307 Hs 10114 growth suppressor 1 20G-Fell_Oxy,TM SS 63
441321 H17182 Hs 7771 B-cell associated protein 8and_7,TM, 63
444637 T19101 Hs 11494 fibulin 5 EGF,TIL,SS 63 413731 BE243845 Hs 75511 connecdve dssue growth factor Cys_knot,tsp_1 ,vwc,IGFBP, 62
422901 R81936 Hs 374568 nbosomal protein L44 sushi.none 62
430397 AI924533 Hs 105607 bicarbonate transporter related pro HC03.cotransp,TM, 6 1
429630 M85289 Hs 211573 heparan sulfate proteoglycan 2 (per EGF.ig laminin.B.laminm. 6 1
434867 AF159442 Hs 103382 phospholipid scramblase 3 SAPA,Scramblase,TM,SS~ 6 1
431449 M55994 Hs 256278 tumor necrosis fxtor receptor supe TNFR.c6,TM,SS 6 1
440676 NM 004987 Hs 112378 LIM and senescent cell andgen-like LIM.SS 60
424658 NM 002406 Hs 151513 mannosyl (alpha-1 ,3-}-glycoproteιn GNT-l,Glycos_transf_2,TM= 59
439310 AF086120 Hs 102793 ESTs casein kappa, kinase.ig.n 59
410169 AI373741 Hs 59384 hypothedcal protein MGC3047 ig.TM. 58
423007 AA320134 Hs 196029 Homo sapiens mRNA for KIAA1657 prot TIMP.none 58
414265 BE410411 Hs 75864 endoplasmic redculum glycoprotein none 58
427715 BE245274 Hs 180428 KIAA1181 protein TM, 58
409220 BE243323 Hs 51233 tumor necrosis fxtor receptor supe TNFR_c6,death,Lιpoproteιn 58
450690 AA296696 Hs 333418 FXYD doman-contanmg ion transpor ATP1G1_PLM_MAT8,TM,SS 58
433848 AF095719 Hs 93764 carboxypepddase A4 Zn_carbOpepLPropep_M14,T 57
446404 AA019961 Hs 26216 LOC50627 none 57
441641 AI650417 Hs 247068 ESTs, Moderately similar to ALU8 HU Pteππ_4a,fibnnogen_C,Co 57
418875 W19971 Hs 233459 ESTs Xlinknone 57
424748 AA346257 Hs 134933 ESTs none 57
439737 AI751438 Hs 41271 Homo sapiens collagen, type VIII, a C1q,Collagen,none 57
448950 AF288687 Hs 9275 CGI-152 protein E1-E2 ATPase.Hydrolase.TM 56
406654 M90686 Hs 73885 HLA-G histocompadbility andgen, c ιg,MHC_l,TM,SS 56
423084 AU076474 Hs 123178 translocase of inner mitochondnal rrm 56
402241 Target Exon p450,TM,SS 56
425157 NM 006227 Hs 283007 phospholipid transfer protein LBP_BPI CETP.LBP BPI CETP 56
428343 AL043021 Hs 12705 ESTs WD40.SS 56
447990 BE048821 Hs 20144 small inducible cytokine subfamily IL8.SS 56
412607 Z33642 Hs 74115 immunoglobulin superfamily, member ig TM.SS 55
447625 AW505364 Hs 19074 LATS (large tumor suppressor, Droso pkιnase,pkιnase_C,UBA,Pol 55
408056 AA312329 Hs 42331 ephπn-A4 Ephπn,TM,SS 55
445960 AI268399 Hs 140489 ESTs, Weakly similar to LIN1.HUMAN zf-C2H2,bZIP,none 55
406874 AW161706 Hs 180842 nbosomal protein L13 Rιbosomal_L13e,SS 54
418558 AW082266 Hs 86131 Fas (TNFRSF6)-assocιated via death death.DED.SS 54
414638 W03516 Hs 76698 stress-associated endoplasmic rede TM.SS 54
409190 AU076536 Hs 50984 sarcoma amplified sequence transmembrane4,TM,SS 54
429150 AF120103 Hs 197366 smoothened (Drosophila) homolog COX8,SHMT,MIF,GST C.EF1G 53
453099 H62087 Hs 31659 thyroid hormone receptor-associated WD40.TM, 53
414443 AU077268 Hs 76144 platelet-denved growth factor rece ig pk ase.TM, 53
441283 AA927670 Hs 131704 ESTs CUB.MAM.F5.F8 type_C,none 53
414249 AI797994 Hs 279929 gp25L2 protein Sulfαtraπsfer,EMP24_GP25L 53
451154 AA015879 Hs 33536 ESTs TIMP.none 52
406655 M21533 Hs 277477 maior histocompadbility complex, c ig MHC_I.TM.SS 52
406656 M16714 Hs 89643 major histocompadbility complex, c fransketolase,transket_py 52
449224 AW995911 Hs 299883 hypothetical protein FLJ 23399 fn3,TM, 52
422562 AI962060 Hs 118397 AE-binding protein 1 Zn carbOpept,F5 F8 type C 52
436127 W94824 Hs 11565 RIKEN cDNA 2010100012 gene TM.SS 52
428327 AW206236 Hs 28773 ESTs cystatm.Coprogen.oxidas, 52
427080 AW068287 Hs 301175 ras-related C3 botulmum toxin subs ras.TM, 52
414624 BE389320 Hs 23628 3 beta hydroxy-delta 5-C27-steroιd none 52
430281 AI878842 Hs 237924 CGI-69 protein mito carr,homeobox,TM,S 52
426433 L38969 Hs 169875 thrombospondin 3 TSPN.tsp 3 EGF.toxm TM 51
432716 AI762964 Hs 205180 ESTs LRR,UPAR_LY6,TM, 5 1
451564 AU076698 Hs 132760 hypothedcal protein MGC15729 sugar_tr,Condensadon,TM= 51
409340 BE174629 Hs 321130 hypothetical protein MGC2771 aa_permeases,pyπdoxal de 5 1
432680 T47364 Hs 278613 interferon, alpha- ducible protein TM.SS 5 1
404913 NM_024408" Homo sapiens Notch (Dros EGF,ank,notch,metalthιo,E 5 1
409485 S80990 Hs 252136 ficoliπ (collagen/fibπnogen domain Collagen.fibπnogen C,TM= 51
432078 BE314877 Hs 24553 hypothetical protein FU 12541 simil TM.SS 5 1
406687 M31126 Hs 352054 matrix metalloproteinase 11 (strome hemopexιn,Pepddase_M10,T 51
423712 W46802 Hs 81988 disabled (Drosophila) homolog 2 (mi PID,MACPF,ldl_recept.a,ts 50
441595 AW206035 Hs 356457 ESTs sugar r.noπe 50
450435 AI695975 Hs 201805 ESTs EGF.Iaminin B.lamin EGF 50
443177 BE268461 Hs 202 benzodiazapine receptor (penpheral TspO MBR.TM.SS 50
433435 BE545277 Hs 340959 Ts Iransladon elongadon factor, m EF.TS.UBA, 50
426386 AA748850 Hs 125830 bladder cancer overexpressed protei none 50
419913 AW270040 Hs 34455 ESTs EPH_lbd,fn3,pkιnase, 50
446696 AF279265 Hs 298476 solute earner family 26, member 6 Sulfate transp,STAS,xan_u 50
448997 AA130390 Hs 25549 hypothetical protem FLJ 20898 TM.SS 50
413891 BE271020 Hs 355753 tumor suppressor deleted in oral ca none 50
453143 AA382234 Hs 356289 protein tyrosine phosphatase, recep serpin.SS 50
448249 AW855331 Hs 337124 ESTs carb anhydrase,UCH-1,UCH- 50
412819 T25829 Hs 24048 FK506 binding protein precursor FKBP.TM.SS 50
426059 BE292842 Hs 166120 interferon regulatory factor 7 IRF.SS 50
432295 BE091049 Hs 343665 πbosomal protein s 15a Rιbosoma!_S8,RNase_PH,KH- 50
412540 C18341 Hs 73999 thyroid hormone receptor interactor SH3.FCH.SS 50
414465 AW270645 Hs 76194 πbosomal protein S5 Rιbosomal_S7, 50
456655 AI376736 Hs 111779 secreted protein acidic, cyste e- kazal.SS 50
421794 X86096 Hs 108371 E2F transcnpdon factor 4, p107/p1 E2F_TDP,KOW,Rιbosomal_L14 49
444824 AA843575 Hs 12056 asialoglycoprote receptor 1 lecdn c.Tropomyosin.TM 49
438278 BE409248 Hs 57988 hypothetical protein FU22357 simil TFIIS,RNA_POL_M_15KD.UPF0 49
418140 BE613836 Hs 83551 mtcrofibrillar-associated protein 2 TM.SS 49
429457 BE243065 Hs 202955 hypothetical protein FU20507 Cys-protease-3C,TM, 49 449475 AI348027 Hs 108557 hypothedcal protein PP1057 transmembrane4,TM,SS 49
425274 BE281191 Hs 155462 minichromosome maintenance deficien MCM.TM, 49
442110 AF113008 Hs 8102 nbosomal protein S20 Rιbosomal_S10,TM, 49
415209 F00183 Hs 172004 ddn none 49
451849 AI199261 Hs 27191 hypothedcal protein from clone 247 TM, 49
421567 AJ272137 Hs 198265 matπx metalloproteinase 25 hemopexm.Pepddase M10YT 49
427380 NM.005534 Hs 177559 interferon gamma receptor 2 (interf fn3,TM,SS 49
431303 AW241605 Hs 253928 ESTs none 49
432396 AW295956 Hs 11900 hypothedcal protein FU14972 Xlιnk,zf-CCCH,G-patch,non 49
415021 R54409 Hs 301693 Homo sapiens, clone IMAGE 3638994, none 48
430498 X02910 Hs 241570 tumor necrosis factor (TNF superfam TNF.TM.SS 48
449957 D31365 Hs 24220 hypothetical protein TM, 48
419603 BE262579 Hs 91566 PL6 protein OMPdecase,TM,SS 48
427588 L25081 Hs 179735 ras homolog gene family, member C ras.none 48
421502 AF111856 Hs 105039 solute earner family 34 (sodium ph Ribosomal L20,Na Pi cotra 48
404854 Target Exon •SS 47
411281 BE392792 Hs 4786 Homo sapiens cONA FU22849 fis, cl cadheπn 47
414045 NM 002951 Hs 75722 nbophoπn II gpdh.gpdh Cpili assembly 47
431830 Y16645 Hs 271387 small inducible cytokine subfamily IL8.SS 47
412896 AW804157 Hs 375570 major histocompadbility complex, c ig MHC.I l_beta,TM,SS 47
429305 AF095727 Hs 287832 myelin protein zero-like 1 ιg,fransmembrane4,TM,SS 47
451698 Y16187 Hs 26880 endothelin converting enzyme-like 1 Pepddase_M13,TM, 47
422687 AW068823 Hs 119206 insulin-like growth factor binding zf-C2H2,ιg,none 47
444542 AI161293 Hs 280380 aminopeptidase NAD binding.flavodoxin.FA 47
429833 NM 012079 Hs 288627 diacylglycerol O-acyltransferase (m ACAT.TM, 47
456376 AA663904 Hs 89862 TNFRSF1 A-associated via death doma death.TM, 47
438568 R98865 Hs 11135 major histocompadbility complex, c MHC_ll_alpha,ιg,none 47
456356 M74715 Hs 89560 iduronidase, alpha-L- Glyco.hydro_39,SS 47
420486 AF036365 Hs 98303 caveolin 3 Caveolin.TM, 46
425123 AW205274 Hs 154695 phosphomannomutase 2 PMM.SS 46
439512 AA418287 Hs 58093 Homo sapiens, done IMAGE 3163559, lamιnιn_EGF,TM, 46
418424 Y13622 Hs 85087 latent transforming growth factor b EGF,TB,spιdertoxιn,granul 46
433350 BE563152 Hs 10362 Homo sapiens cDNA FU 20944 fis, cl zf-C3HC4,SPRY,none 46
432659 AA281633 Hs 278586 KIAA1108 protein TBC TM 46
445417 AK001058 Hs 12680 a dismtegπn-like and melalloprote tsp_ 1. Reprolysιn,Pep_M 12B 46
437408 AL359598 Hs 36606 Homo sapiens mRNA, cDNA DKFZp547B08 none 46
427349 AA360154 Hs 177415 Finkel-Biskis-Reilly muππe sarcoma ubiquitin, TM, 46
418918 X07871 Hs 89476 CD2 andgen (p50), sheep red blood ig.TM.SS 46
421310 AW630087 Hs 103315 tπnucleodde repeat containing 1 PHD 46
427969 NM 001963 Hs 2230 epidermal growth factor (beta-uroga EGF,ldl_recept.b,EB,TM. 46
447860 AF193807 Hs 131835 Flhesus blood group, B glycoprotein Ammonιum_transp,FecCD,TM= 46
418916 BE392781 Hs 89474 ADP-πbosyladon factor 6 arf.ras.TM, 46
425720 AA362394 Hs 293984 hypothedcal protein MGC13102 TM.SS 46
419942 U25138 Hs 93841 potassium large conductance calcium CaKB M.SS 46
403105 Target Exon ISK_Channel,TM,SS 46
418067 AI127958 Hs 83393 cystadn E/M cystadn.SS 46
427863 AF189712 Hs 181002 MLL sepdn- ke fusion GTP CDCTM, 45
458147 AW752597 gb IL3-CT0214-161299-045-B06 CT0214 PMM.none 45
456799 AC004923 Hs 135187 unc93 (C elegans) homolog B TM, 45
427136 AU 17415 Hs 173716 a dismtegnn and metalloproteinase . 45
458766 AW183618 Hs 55610 solute earner family 30 (zinc tran Catιon_efflux,TM,SS 45
445033 AV652402 Hs 72901 cyclin-dependent kinase inhibitor 2 ank, 45
441281 BE501247 Hs 144084 ESTs Collagen,C4,none 45
439720 AI935202 Hs 31181 Homo sapiens cDNA FU23230 fis, cl SDF sugar tr 45
410184 AW503667 Hs 59545 πng finger protein 15 SPRY,zf-B_box,zf-C3HC4,TM 45
431760 NM 005317 Hs 268531 granzyme M (lymphocyte met-ase 1) trypsin.TM.SS 45
446990 AI354717 Hs 223908 ESTs transmembrane4 45
407366 AF026942 Hs 17518 gb Homo sapiens cιg33 mRNA, partial IBR 45
426156 BE244537 Hs 167382 natnuredc pepdde receptor A/guan ANF.receptor.guanylate.cy 45
442941 AU076728 Hs 8867 cysteine-πch, angiogenic mducer, Cys knot,tspJ,vwc,IGFBP, 45
451118 AI862096 Hs 60640 ESTs EGF,vwc,TIL,SS 45
457657 AW411509 Hs 352567 hypothetical protein PR02121 UQ con.TM, 44
437016 AU076916 Hs 5398 guanine monphosphate synthetase PHD.SET zf-CXXC,EGF,ank,n 44
429497 AB028953 Hs 204121 KIAA1030 protein fn3 TM, 44
444090 S69115 Hs 10306 natural killer cell group 7 sequenc PMP22 Claudιn,TM,SS 44
454005 AF039237 Hs 288600 hypothetical protein MGC3123 TM SS 44
412270 AC005262 Hs 73797 guanine nucleotide binding protein G-alpha,arf,TM, 44
406729 AA069711 gb zm52b11 s1 Stratagene fibroblast filamentbZIP,Apolιpoprot 44
404610 Homo sapiens cDNA FU11027 fis, o EGF.Iammin B.lammin EGF 44
422311 AF073515 Hs 114948 cytokine receptor-like factor 1 fn3,TM, 44
406973 M34996 Hs 198253 major histocompadbility complex, c ig MHC II alpha,TM,SS 44
407196 D11747 Hs 177415 Finkel-Biskis-Reilly muπne sarcoma ERG4 ERG24,none 44
404243 NM 006778 Homo sapiens nng finger zf-C3HC4,zf-B_box,TM,SS 44
443834 AI741510 Hs 1 3548 ESTs CUB.MAM,F5_F8_type_C,none 44
446057 AI420227 Hs 366053 Trp-p8 transient receptor potendal none 44
413661 AA071146 Hs 343354 nbosomal protein L18 Rιbosomal.L18e,L15,TM,S 44
414875 H42679 Hs 77522 major histocompadbility complex, c ιg.MHC_ll.alpha,TM,SS 44
439730 AF035292 Hs 6654 KIAA0657 protem fn3,ιg, 43
406257 Target Exon 7tm 1,none 43
434025 AF114264 Hs 216381 Homo sapiens clone HH409 unknown mR ig.TM, 43
414961 U27266 HS 927 myosin-bmding protein H frι3.ιg,TM, 43
430265 L36033 Hs 237356 stromal cell-deπved factor 1 IL8.SS 43
429249 X81479 Hs 2375 egf-like module containing, mucιn-l 7tm_2,EGF,GPS,S_locus_gly 43 433541 AW081538 Hs 220324 hypothedcal protein FU13052 NAD_kιnase,TM, 43
400575 NM 022146 Homo sapiens neuropepdde 7tm_1,TM,SS 43
427661 AA410292 Hs 104761 ESTs wnt,none 43
452056 AW955065 Hs 101150 Homo sapiens, clone IMAGE 4054156, TM, 43
433669 AL047879 Hs 194251 ESTs, Weakly similar to ALU2.HUMAN RNA_pol_L,RNA_pol_L RasGA 43
422624 BE616678 Hs 76152 KDEL (Lys-Asp-Glu-Leu) endoplasmic ER lumen receptnone 43
421680 AL031186 Hs 289106 Human DNA sequence from clone CTA-9 Collagen,TM,SS 43
422766 AA334108 Hs 159572 heparan sulfate (glucosamme) 3-O-s none 43
437596 AA761490 Hs 351250 ESTs, Moderately similar to S65657 pkιnase,WD40 4 3
419285 D31887 Hs 89868 KIAA0062 protein Zip,TM,SS 43
453082 H18835 Hs 31608 hypothedcal protein FU20041 ιon_frans,TM,SS 4 2
410693 BE044206 gb ho40c08x1 Soares_NFL T_GBC S1 H C1q,Collagen,cystad 42
413100 BE065208 gb RC1-BT0314-310300-015-b09 BT0314 none 4 2
432497 AA551104 ESTs, Moderately similar to ALUC_HU none 42
423041 BE170842 Hs 123059 chlonde channel Kb CBS.voltage.CLC M.SS 4 2
449799 AI143466 Hs 125060 ESTs none 4 2
438472 AW974907 Hs 86228 TRIAD3 protein none 4 2
432179 X75208 Hs 2913 EphB3 EPH.Ibd,fn3,pkιnase,SAM,T 4 2
424488 AK000413 Hs 149227 hypothetical protein FU20406 Xlιnk,zf-CCCH,G-patch,TM= 42
406809 AF000574 Hs 22405 leukocyte immunoglobulin-like recep ιg.Gemιnι_mov,TM,SS 4 2
407586 Z37544 Hs 37121 phospholipase C, beta 3 (phosphadd C2,PI-PLC-Y,PI-PLC-X M 42
407228 M25079 Hs 155376 hemoglobin, beta globin.TM, 42
450900 H61005 Hs 37902 ESTs none 42
410188 AL096739 Hs 107260 hypothedcal protein DKFZp586H0623 Ricin.B.ledin.Glycos tra 4 2
458248 BE407379 Hs 108082 ESTs. Weakly similar to T31636 hypo C1q,Collagen,TM,SS 4 2
403138 NM W6056 Homo sapiens G protem-co 7tm_1,HECT,TM,SS 4 2
432074 AA525248 Hs 149723 ESTs Y_phosphatase,none 4 2
438682 AA354489 Hs 375594 EBP50-PDZ interactor of 64 kD none 42
401908 C17000154 gι|12003980|gblAAG43830 1 TM.SS 4 2
451287 AK002158 Hs 26194 likely homolog of mouse immunity-as TM, 4 2
407904 W44735 Hs 107260 Homo sapiens cDNA FU21278 fis, cl none 4 1
403694 Target Exon UDPGT- 4 1
423461 AB020527 Hs 128827 solute earner family 17 (sodium ph sugar πTM, 4 1
425603 U52219 Hs 158329 G protein-coupled receptor 50 7tm_1,TM,SS 1
421485 AA243499 Hs 104800 hypothedcal protein FU 10134 TM.SS 4 1
414509 AW161311 Hs 76294 CD63 andgen (melanoma 1 andgen) transmembrane4,TM,SS 1
423313 NM.014269 Hs 126838 a dismtegnn and metalloproteinase disintegnn.Reprolysin.Pe 4 1
432171 AI202503 Hs 343661 ESTs, Weakly similar to ALUBJHUMAN WD40 1
434652 AF148713 Hs 125830 bladder cancer overexpressed protei WD40.DUF6, 4 1
429592 AB029041 Hs 209646 KIAA1118 protein Troponm,Exo_endo_phos,IQ 4 1
432982 AA531058 Hs 182248 truncated calcium binding protein OPR,ZZ,TM, 4 1
424867 AI024860 Hs 153591 Not56 (D melaπogaster)-lιke protei TM.SS 4 1
441455 AJ271671 Hs 7854 zinc/iron regulated transporter-lik Zιp,TM,SS 4 1
400785 C11000861 gι|9938016|reflNP_064687 TM.SS 4 1
447232 AW499834 Hs 327 interieukin 10 receptor, alpha TM.SS 4 1
450785 AA852713 Hs 108885 Homo sapiens, alpha-1 (VI) collagen vwa.Collagen.TM.SS 4 1
424027 AW337575 Hs 201591 ESTs 7tm_2,HRM,none 4 1
435857 AF253468 Hs 3736 delta-like 4 homolog (Drosophila) EGF,DSL,EB,TM,SS 4 1
437118 AB037857 Hs 300591 CD9 partner 1 none 4 1
411410 R20693 Hs 69954 laminin, gamma 3 lamιnm_B,lamιnιn_EGF,lam 4 1
413902 AU076743 Hs 75613 CD36 andgen (collagen type I recep E2F_TDP,CD36,SS 4 1
428938 AC002425 Hs 194660 ceroid lipofuscmosis, neuronal 3, CLN3,TM,SS 4 1
453094 AA740928 Hs 27356 ESTs none 4 1
440811 BE384713 Hs 74655 ESTs, Weakly similar to T34482 hypo hormone_rec,zf-C4 none 40
407287 AI678812 Hs 345139 gb tu59d08 x1 NCI_CGAP_Gas4 Homo sa ras.cadhenn 40
428028 U52112 Hs 182018 ιnterteukιn-1 receptor-associated k death pkinase.TM, 40
428469 BE549205 Hs 184488 flodllin 2 none 40
423114 AU076497 Hs 1614 cholinergic receptor, nicodmc, al Neur_chan_LBD,Neur chan_m 40
426858 NM.004182 Hs 172791 ubiquitously-expressed transcript OUF232.SS 40
444626 AA320893 Hs 117062 hypothedcal protein FLJ14497 pyr_redox,TM,SS 40
TABLE 30B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
4581 7 1030220J AW848781 AW848490 AW849062 AW752597 AW752699
406729 0 0 AA069711
410693 1054267J BE044206 AW797320 BE161676 AW797356 AW797352
413100 1490226J BE065224 8E065168 BE065313 BE065208
432497 852 71 AW874688 R94134 AA551104 AA777322 AI033094 BE247143
TABLE 30C
Pkey Unique number corresponding to an Eos probeset
Ret Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publication eπdtled 'The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Sfrand Indicates DNA strand from which exons were predicted Nt_posιdon Indicates nucleotide posidoπs of predicted exons
Pkey Ref Strand Nt_posιtιon
401699 3176654 Minus 33285-34084
404864 5263010 Plus 94495-94661,95055-95195,97396-97506,9760 402241 7690131 Minus 125073-125206,130996-131125
404913 7341740 Plus 97717-97976
404854 7143420 Plus 14260-14537
403105 8980016 Minus 145287-145744
404610 9588566 Minus 89583-89725,90402-90555,91428-91673
404243 5672609 Plus 74695-75123
406257 7417784 Plus 55821-56037
400575 9886575 Plus 131603-132095
403138 9211494 Minus 164684-165066,167757-168651
401908 8698760 Minus 126888-127024
403694 7107765 Plus 142925-143080,165505-166186,167486-16763
400785 8131682 Plus 43113-43967
TABLE 31 A ABOUT 189 GENES DOWN-REGULATED IN GLIOMA COMPARED TO NON-MALIGNANT ADULT BRAIN TISSUE
Table 31A lists about 189 genes down-regulated in glioma compared to non-malignant adult bran dssue These were selected as for Table 30A, except that the numerator was set to the 90th percendle amongst vanous non-malignant bran specimens, the denominator was set to the 90th percendle value amongst vanous gliomas, the numerator was greater than or equal to 50 units, and the rado was greater than or equal to 25 (i e 21. fold downreguladon in bran tumor vs normal bran)
Pkey Unique Eos probeset identifier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dde
Protein Domains Predicted Protein Domans
R1 non-malignant adult bran dssue vs glioma
Pkey ExAccn UniGene ID Unigene Tide Protein Domains Rl
412524 AA417813 Hs 44208 hypothedcal protein FU23153 F420 oxιdored,TM,SS 145
432874 W94322 Hs 279651 melanoma inhibitory activity SH3,TM,SS 83
452669 AA216363 Hs 262958 hypothedcal protein DKFZp434B044 SCP,LCCL,TM,SS 82
426300 U15979 Hs 169228 delta-like homolog (Drosophila) EGF.Iaminm EGFJM.SS 82
447990 BE048821 Hs 20144 small inducible cytokine subfamily IL8 SS 73
439477 W69813 Hs 58042 ESTs, Moderately similar to GFR3.HU GDNF.TPR 71
411602 L01406 Hs 767 growth hormone releasing hormone re 7tm_2,HRM,TM,SS 6 1
417067 AJ001417 Hs 81086 solute earner family 22 (extraneur sugar_tr,TM,SS 60
426488 X03350 Hs4 alcohol dehydrogenase 18 (class I), adh ziπc.TM, 59
447656 NM.003726 Hs 19126 src kinase-associated phosphoprotei SH3.PH M, 53
436950 L05779 Hs 113 epoxide hydrolase 2, cytoplasmic abhydrolase,Hydrolase,TM= 52
406837 R70292 Hs 156110 immunoglobulin kappa constant 49
410387 AI277367 Hs 47094 ESTs 48
432855 AF017988 Hs 279565 secreted frizzled-related protein 5 Fz,NTR,TM,SS 47
441499 AW298235 Hs 101689 ESTs 46
421481 AW391972 Hs 104696 KIAA1324 protein TM.SS 45
420255 NM 007289 HS 1298 membrane metallo-endopepddase (neu Pepddase_M13TM,SS 45
407230 AA157857 Hs 182265 keradn 19 fil3meπtbZIP,SS 44
412445 X51362 Hs 73893 dopamine receptor D2 7tm.1,TM,SS 43
413966 AA133935 Hs 173704 ESTs, Moderately similar to A53959 42
415165 AW887604 Hs 78065 complement component 7 ldl_recept_a,sushι,tsp 1, 42
420103 AA382259 Hs 95197 aldehyde dehydrogenase 1 family, me aldedhJM, 42
426723 AW003069 Hs 183860 ESTs GNT-I,TM,SS 4 1
409081 AJ010277 Hs 50403 T-box 19 T-box,TM, 40
407142 AA412535 gb zt99b10 s1 Soares_tesds_NHT Horn Na sulph.symp.TM, 40
414449 AA557660 Hs 76152 decoπn LRRNT,LRR,LRR,LRRNT 40
444784 D12485 Hs 11951 ectonucleodde pyrophosphatase/phos Somatomedm.B, Endonucleas 39
420321 D78761 Hs 96657 hyothedcal protein tsp 1.SS 38
401700 Target Exon TM, 38
418807 NM 004944 Hs 88646 deoxyπbonuclease 1-lιke 3 Exo endo_phos,TM,SS 38
406746 AA580395 Hs 279860 tumor protein, transladonally-cont TCTP.TM, 37
449077 AW262836 Hs 252844 ESTs 37
415718 F30631 Hs 200237 ESTs isoamylase.N 37
402449 Target Exon pkmase,LRR,LRRCT,TM,SS 36
457489 AI693815 Hs 127179 cryptic gene TM.SS 36
406743 AA911568 Hs 279860 tumor protein, translationally-cont TCTP.TM, 36
416950 AL049798 Hs 80552 dermatopondn 36
451554 AI474866 Hs 193237 ESTs 36
440708 AF038962 Hs 7381 voltage-dependent anion channel 3 Euk.ponn,Enterotoxιn_A,P 35
426095 AI278023 Hs 89986 ESTs WD40,none 35
406742 AI468091 Hs 279860 tumor protein, transladonally-cont TCTP.TM, 35
429343 AK000785 Hs 199480 Homo sapiens, Similar to epsin 3, c VHS,ENTH,UIM,SS 34
439457 AF086274 gb Homo sapiens full length insert 34
408796 AA688292 Hs 170345 ESTs hormone rec,zf-C4 34
440659 AF134160 Hs 7327 claudin 1 PMP22 Claudιn,TM,SS 34
415042 NM 006759 Hs 77837 UDP-glucose pyrophosphorylase 2 UOPGP.SS 34
417967 BE244373 Hs 1119 nuclear receptor subfamily 4, group hormone_rec,zf-C4,none 33
445234 AW137636 Hs 146059 ESTs 14-3-3,none 33
430511 BE018156 Hs 2575 calpain 1 , (mu/l) large subunit efhand.Peptidase C2,Calpa 33
420485 AF218586 Hs 288835 cell death-inducing DFFA-like effec 7tm 1,CIDE-N,TM,SS 33
413687 AI522318 Hs 103819 ESTs TM.SS 33
428928 BE409838 Hs 194657 cadheπn 1, type 1, E-cadhenn (epi cadheπn,Cadheπn_C_term, 33
409738 BE222975 Hs 56205 insulin induced gene 1 33
442046 AA974575 Hs 287385 ESTs zf-C2H2,SET,TM, 32
413127 BE066529 gb RC3-BT0333-300300-017-a12 BT0333 32
429350 AI754634 Hs 131987 ESTs MAM M, 32
427980 AA418305 Hs 303205 EST LRRnone 32 424498 AB033043 Hs 149377 hypothedcal protein DKFZp761L0424 AIP3.TM.SS 32
435684 NM_001290 Hs 4980 LIM domain binding 2 UM_bιnd.TM, 32
402632 Target Exon ιg,TM.SS 3 1
431130 NM 006103 Hs 2719 HE4, epididymis-specific, whey-acid wap,TM,SS 3 1
410636 AA088177 Hs 172870 ESTs TM.SS 3 1
452658 N88604 Hs 30212 thyroid receptor interacdng protei PCI.TM, 3 1
453180 N46243 Hs 110373 ESTs, Highly similar to T42626 seer laminin G.LRRCT.πone 3 1
430319 AI480214 Hs 356075 ninjurin 2 TM.SS 3 1
438424 AI912498 Hs 25895 hypothedcal protein FU14996 C2TM 3 1
456063 NM 006744 Hs 76461 retinol-bindmg protein 4, intersd lipocalin,TGF-beta,TGFb p 3 1
429798 AL117578 Hs 222909 DKFZP434C128 protein TM, 31
417677 NM_016055 Hs 82389 CGI-118 protein 3 1
443792 AI763073 Hs 204873 ESTs 3 1
445861 BE293423 Hs 11809 single Ig IL-1R-related molecule TIR.TM, 3 1
407815 AW373860 Hs 183860 hypothedcal protein FU20277 LRR,none 3 1
456689 NM 002251 Hs 117780 potassium voltage-gated channel, de ion frans.K tetra.TM.SS 3 1
446492 AW205115 Hs 161287 ESTs SPRY,zf-B_box,PAAD_D 3 1
427706 AW971225 Hs 293800 ESTs, Weakly similar to ALU1 HUMAN 30
458008 AA809314 Hs 123295 ESTs SCAN,zf-C2H2,none 30
449708 AI694598 Hs 202126 ESTs 30
410132 NM.003480 Hs 300946 Microfibπl-associated glycoprotein TM.SS 30
423778 Y09267 Hs 132821 flavin containing monooxygenase 2 FMO-lιke,pyr_redox,TM,S 30
425280 U31519 Hs 1872 phosphoenolpyπjvate carboxykinase 1 PEPCK M, 30
453177 AW389509 Hs 223747 ESTs zf-C2H2,none 30
416781 AF072928 Hs 79877 myotubulaπn related protein 6 30
447582 BE293520 Hs 18910 prostate cancer overexpressed gene sugar_tr;TM,SS 30
417365 D50683 Hs 82028 transforming growth factor, beta re pkιnase,WD40,TM, 30
452540 AW161048 Hs 150549 ESTs, Weakly similar to T33997 hypo 29
430233 AW367902 Hs 236443 Homo sapiens mRNA, cDNA DKFZp564N10 PH,Ets,CH,spectnn,Ca_cha 29
418127 BE243982 Hs 83532 membrane cofactor protein (CD46, fr sushi M.SS 29
404445 Target Exon 29
423323 AI951628 Hs 127007 potassium channel, subfamily K, mem ιon_trans,TM,SS 29
452093 AA447453 Hs 27860 Homo sapiens mRNA, cDNA DKFZp586M07 7tm_1,none 29
427981 BE275986 Hs 181311 asparaginyl-tRNA synthetase tRNA-synt_2,tRNA_and,tRN 29
452242 R50956 Hs 159993 gycosyltransferase 29
440232 AI766925 Hs 112554 ESTs 29
444634 AW611988 Hs 197813 ESTs CKS 29
445889 BE465186 Hs 266958 ESTs TM, 29
414483 R25513 Hs 10683 ESTs 29
453500 AI478427 Hs 43125 esophageal cancer related gene 4 pr TM.SS 29
419768 T72104 Hs 93194 apolipoprotein A I Apolipoprotein, SS 29
427804 AL049654 Hs 180871 protein kinase C, alpha binding pro PDZ.SS 29
423753 Y11312 Hs 132463 phosphomosιdde-3-kιnase, class 2, C2,PI3_PI4_kιnase,PI3Ka,P 29
430699 AW969847 Hs 292718 ESTs Weakly similar to RET2.HUMAN lipocahn.SS 29
427842 AW936961 gb RC1-DT0029-160200-013-a12 DT0029 efhand,mιto_carr,none 28
432834 F06459 Hs 289113 cytochrome b5 reductase 1 (B5R 1) NAD_bιndιng FAD_bmdmg_6 28
421435 AW972072 Hs 372167 ESTs 28
402458 C1002064 gι|11993050|gb|AAG4257 1| TM.SS 28
410036 R57171 Hs 57975 calsequestπn 2 (cardiac muscle) Calsequestnn SS 28
412570 AA033517 Hs 74047 electron-transfer-flavoprotein, bet ETF_beta,SS 28
459439 AW402931 Hs 352411 gb UI-HF-BKO-abd-a-01-O-UI r1 NIH_M 28
438622 L03151 gb Homo sapiens cell type T-cell im 28
417023 AA192278 Hs 301596 ESTs Moderately similar to S65657 28
453281 W46280 Hs 55940 ESTs, Weakly similar to A25704 syna 28
403028 Target Exon trγpsin.trefoil 28
449029 N28989 Hs 22891 solute carrier family 7 (cadonic a aa_permeases,TM,SS 28
425483 AF231022 Hs 158159 FAT tumor suppressor (Drosophila) h EGF,cadheππ,lammιn G,TM 28
406918 M88357 gb Homo sapiens DNA-binding protein zf-C2H2,KRAB,zf-BED,TM, 27
435213 AA092510 Hs 5985 non-kmase Cdc42 effector protein S TM, 27
443990 AW205085 Hs 39557 ESTs 27
451698 Y16187 Hs 26880 endothelin converting enzyme-like 1 Pepddase M13 TM, 27
431713 AK000388 Hs 267997 EHM2 gene Band 41, TM 27
431469 N49424 Hs 124159 ESTs SH3 27
400386 AF075290 gap juncdon protein, alpha 3, 46kD connexin.TM.SS 27
406684 X16354 Hs 50964 carciπoembryonic andgen-related ce ιg,TM,SS 27
449874 AA135688 Hs 10083 Homo sapiens clone IMAGE 4139786, TM 27
403213 NM M9595 Homo sapiens mtersecdn SH3,efhand,C2,PH,RhoGEF,T 27
459665 BE159784 Hs 47647 gb MRO-HT0408-220300-001-h06 HT0408 27
421823 N40850 Hs 28625 ESTs 27
422693 BE300073 Hs 279860 tumor protein, transladonally-cont TCTP.none 27
454906 AI219323 Hs 101077 ESTs, Weakly similar to T22363 hypo TM 27
447075 AV662037 Hs 124740 ESTs, Weakly similar to I38022 hypo TM, 27
450273 AW296454 Hs 24743 hypothedcal protein FU20171 rrm none 27
434340 AI193043 Hs 128685 ESTs, Weakly similar to T17226 hypo 27
436972 AA284679 Hs 25640 claudin 3 PMP22_Claudm,TM,SS 27
441379 AW175787 Hs 334841 selenium binding protein 1 TM 27
421143 AB024536 Hs 102171 immunoglobulin superfamily contani ιg,LRR,LRRNT,LRRCT,TM,S 27
422558 NM 006420 Hs 118249 brefeldiπ A-inhibited guanine nude Sec7,none 27
428900 AA437189 Hs 352324 Human DNA sequence from clone RP1-6 SS 27
421153 AF009267 Hs 102238 Homo sapiens clone FBA1 Cπ-du-chat 27
427074 AA527435 Hs 178589 hepatocellular carcinoma antigen ge efhand TM, 26
448133 AA723157 Hs 73769 folate receptor 1 (adult) Folate_rec,MIP,TM,SS 26
419158 AF031475 Hs 89648 arginine vasopressm (neurophysm I hoππone5,hormoπe4,SS 26 448406 AW772298 Hs 21103 Homo sapiens mRNA, cDNA DKFZp564B07 26
437176 AW176909 Hs 42346 calcineunn-binding protein calsarc GalactosyLT.TM.SS 26
435075 R51094 Hs 12400 ESTs 26
403153 Target Exon 26
400387 AF133131 double homeobox, 5 26
425940 AB023184 Hs 163990 KIAA0967 protein PDZ.SS 26
416157 NM 003243 Hs 342874 transforming growth factor, beta re zona_pellucιda,TM,SS 26
452554 AW452434 Hs 58006 ESTs, Weakly similar to ALU5 HUMAN HLH,PAC,PAS,none 26
453247 T80198 Hs 111806 ESTs vwa.Cache.none 26
407744 AB020629 Hs 38095 ATP-binding cassette, sub-family A ABC_tran,PRK,TM,SS 26
432877 AW974111 Hs 292477 ESTs Ets.SAM.PNT.none 26
450115 AI591038 Hs 38132 ESTs 26
406337 C14000021 gιl7242973|db||BAA92547 1 Pepddase M22 26
430877 NM 005269 Hs 2693 glioma-associated oncogene homolog zf-C2H2,SS 26
453874 AW591783 Hs 36131 collagen, type XIV, alpha 1 (unduli 26
450493 M93718 Hs 166373 nitnc oxide synthase 3 (endothelia NAD.binding.flavodoxin.FA 26
427620 NM 003705 Hs 179866 solute earner family 25 (mitochond efhand,mιto_carr,TM,SS= 26
446585 AV659397 Hs 299668 ESTs, Weakly similar to I38022 hypo 26
427223 . BE208189 Hs 174031 cytochrome c oxidase subunit Vlb tubulιn,FKBP,COX6B,7tm_1, 26
428111 S7661 Hs 2243 B lymphoid tyrosine kinase SH2,SH3,pkιnase,SS 26
440133 AI056255 Hs 133349 ESTs 26
419693 AA133749 Hs 301350 FXYD doman-contanmg ion transpor ATP1G1 PLM.MAT8,TM,SS 26
417103 Z33905 Hs 81218 hypothetical protein MGC3597 TPR,zf-C3HC4,PHD,TM,SS= 26
419100 AA464362 Hs 6748 hypothedcal protein PP1665 squash.GDPD M, 26
449925 AI342493 Hs 24192 Homo sapiens cDNA FU20767 fis, do 26
430937 X53463 Hs 2704 glutathione peroxidase 2 (gastroint GSHPx,SS 26
425640 U34051 Hs 158460 cyd -dependent kinase 5, regulato CDK5_acdvatoπTM, 26
409021 AA156640 Hs 49881 fatty acid binding protein 3, muscl lipocalin.none 26
400538 ENSP00000239776* BA425A6 2 (similar TM.SS 26
446947 AF146747 Hs 232165 polycythemia rυbra vera 1, cell sur TM.SS 26
408310 AW179023 Hs 191705 gb PM3-ST0036-170899-001-e08 ST0036 26
433032 AI084066 Hs 20072 myosin regulatory light chan inter Band_41, 26
419389 AI074951 Hs 319095 ESTs DPPIV N term none 26
453145 R63438 Hs 183454 Homo sapiens cDNA FLJ14883 fis, o STT3 M,SS 26
443460 AL050275 Hs 9383 DKFZP566D213 protein EGF.Iamimn EGF,EB,TM,S 26
421903 AW079940 Hs 15951 ESTs, Weakly simila to S32436 coll SS 25
421757 Z20897 Hs 296259 paraoxonase 3 Arylesterase.SS 25
428475 AF172940 Hs 184542 CGI-127 protein 25
424657 AA344719 gb EST50901 Gall bladder II Homo sa 25
432862 AW004958 Hs 236720 ammonless protein TM.SS 25
427195 W27230 Hs 173912 eukaryotic traπsladon inidadon f DEAD,helιcase_C, 25
447770 AB032417 Hs 19545 frizzled (Drosophila) homolog 4 Fz,Fπzzled,7tm_2,TM,SS 25
456523 AI083668 Hs 50601 hypothedcal protein MGC10986 pkinase none 25
451846 T65840 Hs 11762 ESTs 25
432906 BE265489 Hs 3123 lethal giant larvae (Drosophila) ho WD40.TM, 25
453876 AW021748 Hs 110406 ESTs, Weakly similar to I38022 hypo 25
441488 AW450935 Hs 7862 hypothetical protem FU20312 TM, 25
444669 F18939 Hs 153827 ESTs 25
452497 AA732153 Hs 27865 Homo sapiens cDNA FU21333 fis cl 25
TABLE 31 B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
439457 23338 1 AF086274W69434 W6951
413127 151610.1 BG007296 BF330853 BF747375 BE066356 BE066292BF330900 BF747142 BE066419 BF742510 BE066529 BE06
BE066274 BF334312
427842 1164138 1 AW936960 AW936961 AA416706 R29415
438622 46171 1 L03151 L03155 L03161
424657 896375 1 AW963487 AA365077 AA344719
TABLE 31 C
Pkey Unic |ue number conesponding to an Eos probeset
Ref Seq uence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al ' ' refers to the p sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted
Nt_posιdon Indicates nudeodde posidoπs of predicted exons
Pkey Ref Strand Nt_posιdon
401700 3176654 Minus 3541635534
402449 9796674 Plus 59867-60039,62588-62828,63465-636236492
402632 9931268 Plus 101166-101419
404445 7596866 Minus 31112-31423
402458 9796782 Plus 170479-171134
403028 7670577 Minus 114150-114272
403213 7630897 Minus 162572-162739,164442-164540
403153 9799871 Minus 42232-43389
406337 9213455 Plus 90117-90337
400538 9797838 Plus 8752-9822 TABLE 32A ABOUT 68 GENES UP-REGULATED IN GLIOMA COMPARED TO NORMAL ADULT TISSUES AND TO NON MALIGNANT BRAIN TISSUES THAT ARE LIKELY TO ENCODE PROTEINS AMENABLE TO MODULATION BY SMALL MOLECULES, PEPTIDES, OR ANTIBODIES
Table 32A lists about 68 genes up-regulated in glioma compared to normal adult tissues and to non malignant brain dssues that are likely to encode protems amenable to modulation by small molecules, pepddes, or andbodies These were selected from the starting collecdon of 59680 probesets on the Affymetnx/Eos-Hu03 GeneChip® array as follows the ratio of "average" glioma to "average" normal adult dssues was greater than or equal to 25, the rado of "average" glioma to "average* non-malignant brain dssues was greater than or equal to 20, the "average" glioma level was set to the 98th percendle value amongst vanous glioma specimens, the "average" normal adult dssue level was set to the 85th percendle value amongst vaπous non-malignant dssues, the "average* non-malignant bran dssues level was set to the 90th percendle value amongst vanous non-malignant bran dssues the "average* glioma value was greater than or equal to 50 units, and the predicted protein contained a structural domain that is indicative of having an oncogenic funcdon or of transducing an intracellular signal, or of being modulatable by small molecules, pepddes, or andbodies (e g pkinase, death-domain, 7tm, phosphatase, or lon.transporter) Predicted protein domains are noted
Pkey Unique Eos probese t identifier number
ExAccn Exempla Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dde
Protein Domains Predicted Protein Domains
R1 glioma vs normal adult dssues and non-malignant bran tissues that are likely to encode proteins
Pkey ExAccn UmGene ID Unigene Tide Protein Domans R1
424343 AW956360 Hs 4748 adenylate cyclase activating polype 7tm.2,HRM 88
418506 AA084248 Hs 85339 Unknown protein for MGC 29643 (form 78
456723 Z43902 Hs 4748 adenylate cyclase acdvadng polype 7tm_2,HRM 75
430228 AW950939 Hs 6382 ESTs, Highly similar to T00391 hypo 7 1
436480 AJ271643 Hs 87469 putative acid-sensing ion channel ASC M, 63
407603 AW955705 Hs 62604 Homo sapiens, clone IMAGE 4299322, TM, 60
414825 X06370 Hs 77432 epidermal growth factor receptor (a Funn-lιke,pkιnase,Recep 60
423779 AW071837 Hs 57971 ESTs TNFR.C6 55
409638 AW450420 Hs 21335 ESTs 7tm_2,HRM 53
442613 AI004002 Hs 130522 Kv channel-interacdng protein 1 Neur_chan_LBD,Neur_c 52
436456 AW292677 Hs 248122 G protein-coupled receptor 24 51
424340 AA339036 Hs 7033 ESTs lig chan.ANF receptor.non 50
425115 R44664 Hs 123956 ESTs 7tm.1 47
446809 AW590171 Hs 101413 ESTs CaMBD,SK_channel.CaMBD,SK 44
413278 BE563085 Hs 833 interferon-sdmulated protein, 15 k ubiquitin, SS 44
454360 L78207 Hs 54470 ATP-bindmg cassette, sub-family C ABC.tran.ABC membrane.PRK 42
414821 M63835 Hs 77424 Fc fragment of IgG, high affinity I ig.TM.SS 42
428141 D50402 Hs 182611 sdute earner family 11 (proton-co Nramp.TM, 4 1
435472 AW972330 Hs 283022 tπggeπng receptor expressed on my -g,TM,SS 41
435615 Y15065 Hs 4975 potassium voltage-gated channel, KQ ιon_trans,KCNQ1.channel.T 38
448204 AI475124 Hs 170561 ESTs lιg_chan,SBP_bac_3 37
433290 R20077 Hs 302185 Homo sapiens ctone 23618 mRNA seque lig chan.SBP bac 3.ANF re 36
408243 Y00787 Hs 624 interieukin 8 HLH,PAS,IL8 TM, 36
415849 R20529 Hs 6806 ESTs 7tm 2,GPS,Gal Lecdn.HRM, 35
451099 R52795 Hs 25954 interieukin 13 receptor, alpha 2 fπ3,TM,SS 34
445070 NM_000677 Hs 258 adenosine A3 receptor 7tm_1,TM,SS 34
428037 N47474 Hs 89230 potassium intermediate/small conduc CaMBD.SK channel 32
444006 BE395085 Hs 10086 type 1 transmembrane protein Fn14 ldl_recept_a,PKD.MHC_l,TM 31
447143 AW292408 Hs 152290 ESTs, Highly similar to JC2463 vaso 30
418054 NM 002318 Hs 83354 lysyl oxidase-like 2 SRCR.Lysyl oxidase.TM.S 30
424441 X14850 Hs 147097 H2A histone family, member X histoπe.CBFD.NFYB.HMF.TM- 30
446057 AI420227 Hs 366053 Trp-p8 transient receptor potential 29
438204 AI589645 Hs 128690 ESTs 7tm 1 29
431674 AA098901 Hs 301642 G-protem coupled receptor GCV_H 29
424028 AF055084 Hs 153692 Homo sapiens CDNA FU14354 fis do 29
415209 F00183 Hs 172004 ddn 28
438537 AK000511 Hs 6294 hypothetical protein DKFZp434L1435 tRNA-synt_1,TM, 28
431053 S40369 Hs 249141 Glutamate receptor subunit l.g_chan,ANF_receptor,TM= 28
408482 NM 000676 Hs 45743 adenosine A2b receptor 7tm.1,TM,SS 28
414774 X02419 Hs 77274 plasmmogen activator, urokmase kπngle.tiypsin plantjhi 28
426865 D63476 Hs 172813 PAK-interacdng exchange factor bet SH3,PH,RhoGEF,Terpeπe_syn 28
430897 U71092 Hs 248122 G protein-coupled receptor 24 7tm_1,TM, 27
438993 AA828995 gb Od77b08 s1 NCI_CGAP_Ov2 Homo sap EGF,metalthιo,ιntegnn_B, 27
409552 AL119675 Hs 54929 phosphorylase kinase, gamma 1 (muse pkmase.Bac DNA bindmg.T 27
412817 AL037159 Hs 74619 proteasome (prosome, macropain) 26S PC rep.TM, 27
429150 AF120103 Hs 197366 smoothened (Drosophila) homolog COX8,SHMT,MIF,GST_C,EF1G_ 27
419508 AW997938 Hs 90786 ATP-bindmg cassette, sub-family C ABC_tran,ABC_membrane,TM= 27
417880 BE241595 Hs 82848 selecdn L (lymphocyte adhesion mol EGF,lectιn_c sushi TM S 27
432074 AA525248 Hs 149723 ESTs Y_phosphatase 26
402154 NM_031896* Homo sapiens calcium cha PMP22_Claudιn,TM,SS 26
431222 X56777 Hs 273790 zona pellucida glycoprotein 3A (spe zona_pellucιda,TM,SS 26
419913 AW270040 Hs 34455 ESTs EPHJbd,fn3,pkιnase 26
412802 U41518 Hs 74602 aquaponn 1 (channel-forming integr MIP.TM.SS 26
412070 AW893260 gb CM2-NN0010-100300-111-e09 NN0010 7tm_2,HRM 26
422676 D28481 Hs 1570 histamme receptor H1 7tm 1,TM,SS 26
422311 AF073515 Hs 114948 cytokine receptor-like factor 1 fn3 TM, 26
444381 BE387335 Hs 283713 hypothedcal protein BC014245 Collagen.TM.SS 26
419972 AL041465 Hs 182982 golgιn-67 26
418526 BE019020 Hs 85838 solute caner family 16 (monocarbo TM SS 26
421997 R66740 Hs 110613 KIAA0220 protein aa_permeases,pyπdoxal_de 26
430181 AF065314 Hs 234785 cyclic nudeodde gated channel alp cNMP_bιndιπg,ιoπ_trans,TM 25
426318 AA375125 Hs 147112 Homo sapiens cDNA FU22322 fis. cl EPH lbd,pkιnase,fπ3,SAM,n 25
434808 AF155108 Hs 256150 NY-REN-41 antigen TM, 25
418843 AJ251016 Hs 89230 potassium intermediate/small conduc CaMBD SK.channel.TM SS= 25
410290 AA402307 Hs 322844 hypothetical protein DKFZp564A176 Sema PSI,TIG,ιntegπn_B,T 25 424909 S78187 Hs 153752 cell division cycle 25B Rhodanese.SS 25
408369 R38438 Hs 182575 SLC15A2 Solute earner family 15 (H PTR2.TM, 25
414561 AI064813 Hs 195155 Homo sapiens ammo acid transport s Aa rans.TM, 25
TABLE 32B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession
438993 2580163.1 AI926361 AA834879 AA828995
412070 287551.1 BG820657 AW890808 BF904755 AW893260 BI034684 BF963423 BF961550 M85689
TABLE 32C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham, et al " refers to the publicadon endtled 'The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposidon Indicates nudeodde positions of predicted exons
Pkey Ref Strand Nt_posιdon 402154 8516165 Minus 125299-125494 TABLE 33A ABOUT 798 GENES UP-REGULATED IN KIDNEY CANCER
Table 33A lists about 798 genes up-regulated in kidney cancer compared to normal adult dssues These were selected from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the rado of "average" kidney cancer to "average* normal adult dssues was greater than or equal to 30 The "average" kidney cancer level was set to the 90th percentile amongst vaπous kidney cancers The "average" normal adult dssue level was set to the 90th percendle amongst vaπous non-malignant tissues In order to remove gene- specific background levels of non-specific hybridization, the 15th percendle value amongst the vaπous non-malignant dssues was subtracted from both the numerator and the denominator before the ratio was evaluated
Pkey Unique Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dfle R1 Ratio of tumor to noπnal dssue
Pkey ExAccn UniGenelD Unigene Tide R1
421471 U90545 Hs 104635 solute earner family 17 (sodium phospha 10074
445178 AI792241 Hs 129614 kidney-specific membrane protein 4380
452401 NM 007115 Hs 29352 tumor necrosis factor, alpha-induced pro 3364
421727 Y13153 Hs 107318 kynurenine 3-moπooxygenase (kynuremne 3 3236
440304 BE159984 Hs 125395 ESTs 2950
436878 BE465204 Hs 47448 ESTs 2588
452795 AW392555 Hs 18878 hypothedcal protein FLJ21620 2586
421155 H87879 Hs 102267 lysyl oxidase 251 8
426471 M22440 Hs 170009 transforming growth fxtor alpha 2246
421478 AI683243 Hs 97258 ESTs 2126
424086 AI351010 Hs 102267 lysyl oxidase 1992
428296 NM.003058 Hs 183572 solute earner family 22 (organic cation 1864
426890 AA393167 Hs 41294 ESTs 1834
441031 AI110684 Hs 7645 fibnnogen, B beta polypeptide 1740
411642 NM 014932 Hs 71132 neuroligin 1 1724
452838 U65011 Hs 30743 preferentially expressed antigen in mela 161 4
425984 AW836277 Hs 165636 hypothetical protein DKFZp761C07121 151 0
438966 AW979074 gb EST391184 MAGE resequences, MAGP Homo 1350
453165 S74727 Hs 32042 aspartoxylase (aminoxylase 2, Canavan 1348
453160 AI263307 Hs 146228 ESTs 1326
452431 U88879 Hs 29499 toll-like receptor 3 1306
423508 AW604297 Hs 129711 hepadds A virus cellular receptor 1 1204
420642 AK001520 Hs 99545 Homo sapiens cDNA FU 10658 fis clone NT 1126
407975 X89426 Hs 41716 endothelial cell-specific molecule 1 (NO 111 8
431708 AI698136 Hs 108873 ESTs 1098
446460 AW013999 Hs 150164 ESTs 1036
443450 N66045 Hs 133529 ESTs 1030
432865 AI753709 Hs 152484 ESTs 101 4
442438 AA995998 gb os26b03 s1 NCI.CGAP.Kid5 Homo sapiens 988
433447 U29195 Hs 3281 neuronal pentraxin II 985
440311 AI733079 Hs 125407 ESTs, Moderately similar to ALUE.HUMAN ι 982
415076 NM 000857 Hs 77890 guanylate cyclase 1, soluble, beta 3 970
437157 BE048860 Hs 120655 ESTs 944
453319 AI985369 Hs 20117 ESTs 91 4
447046 AA326187 Hs 17170 G protein-coupled receptor 4 902
439169 AI912122 Hs 41095 ESTs 866
431870 AW449902 Hs 105500 ESTs 844
438993 AA828995 gb od77b08s1 NCI CGAP Ov2 Homo sapiens 838
445279 R41900 Hs 22245 ESTs 824
451592 AI805416 Hs 213897 ESTs 794
422966 AV648419 Hs 122613 dimethylglycine dehydrogenase precursor 788
423109 M59305 Hs 123655 natnuredc pepdde receptor C/guanylate 780
415989 AI267700 HS 111128 ESTs 770
422544 AB018259 Hs 118140 KIAA0716 gene product 748
425878 AW964806 Hs 38085 ESTs, Weakly similar to putative glycine 748
429352 AK001512 Hs 200097 hypothedcal protein FU 10650 730 453392 U23752 Hs 32964 SRY (sex determining region Y)-box 11 72 2
441665 AI301355 Hs 151285 ESTs 71 6
435094 AI560129 Hs 277523 EST 71 2
403345 696
430440 X52599 Hs 2561 nerve growth fxtor, beta polypepdde 690
440482 AA886658 Hs 50873 ESTs 676
457100 AA417878 Hs 48401 ESTs, Weakly simila to ALU8JHUMAN ALU S 670
420637 AW976153 gb EST388262 MAGE resequences. MAGN Homo 65 2
407905 AW103655 Hs 252905 ESTs 63 2
422998 AK000588 Hs 122939 hypothetical protein FU20581 61 8
432267 AK000872 Hs 274227 Homo sapiens cDNA FU 10010 fis, clone HE 61 2
449448 D60730 Hs 57471 ESTs 606
431941 AK000106 Hs 272227 Homo sapiens cDNA FU20099 fis, clone CO 59 8
419752 AA249573 Hs 152618 ESTs 584
449579 AW207260 Hs 134014 prostate cancer associated protein 6 582
408609 AA330431 Hs 640 calcitonin receptor 574
451009 AA013140 Hs 115707 ESTs 57 2
435610 AI862767 Hs 114157 ESTs, Weakly simila to putadve p150 [H 564
411893 R82845 Hs 273789 ESTs 562
415227 AW821113 Hs 72402 ESTs 552
433859 AW896758 Hs 163925 ESTs 550
450459 AI697193 Hs 299254 ESTs 544
400302 N48056 Hs 1915 folate hydrolase (prostate-specific memb 534
421831 AA298836 Hs 22026 ESTs 528
438817 AI023799 Hs 163242 ESTs 52 1
449101 AA205847 Hs 23016 G protein-coupled receptor 520
410025 BE220489 Hs 113592 ESTs 51 8
423685 BE350494 Hs 49753 Homo sapiens mRNA for KIAA1561 protein, 480
436751 AA732217 Hs 294054 ESTs 466
445424 A8028945 Hs 12696 cortxtin SH3 domain-binding protein 454
444059 R69743 Hs 75442 albumin 448
442671 AI005668 Hs 134779 EST 444
445657 AW612141 Hs 279575 ESTs 443
452891 N75582 Hs 212875 ESTs, Weakly similar to KIAA0357 [H sapi 440
423735 AA330259 gb EST33963 Embryo, 12 week II Homo sapi 438
422553 AI697720 Hs 171455 ESTs 436
452461 N78223 Hs 108106 transcπption fxtor 428
408430 S79876 Hs 44926 dipepddylpepddase IV (CD26, adenosine 42 6
452240 AI591147 Hs 61232 ESTs 41 7
445186 AW614544 Hs 123641 protein tyrosine phosphatase, receptor t 41 4
452788 AW294571 Hs 136040 ESTs 41 4
419287 X91906 Hs 89872 chlonde channel 5 (nephrolithiasis 2, X 406
428822 W28418 Hs 301148 potassium voltage-gated channel. Isk-rel 402
412359 AW837985 gb QV3-LT0048-140200-083^05 LT0048 Homo 400
434208 T92641 Hs 127648 hypothetical protein PR02176 39 2
442168 AI253165 Hs 146022 ESTs 388
400792 AA635062 Hs 50094 Homo sapiens mRNA, cDNA DKFZp434O0515 (f 386
445900 AF070526 Hs 13429 Homo sapiens clone 24787 mRNA sequence 384
444743 AA045648 Hs 11817 nudix (nucleoside diphosphate linked moi 384
428795 R45503 Hs 97469 ESTs Weakly similar to I49698 alpha-1,3 37 6
406411 37 6
423657 AL045128 Hs 1691 glucan (1,4-alpha-), branching enzyme 1 375
417218 AA005247 Hs 285754 met proto-oncogene (hepatocyte growth fa 372
448788 AI570286 Hs 107070 ESTs 37 2
441826 AW503603 Hs 129915 phosphotπesterase related 370
409263 AA069573 Hs 50319 ESTs 368
425577 BE464496 Hs 280977 ESTs 36 2
452249 BE394412 Hs 61252 ESTs 348
435986 AA703158 Hs 187848 ESTs 344
417236 AI908497 Hs 170737 Homo sapiens cDNA FU23251 fis, clone C 338
440234 AW117264 Hs 126252 ESTs 338
435334 R94223 Hs 117747 ESTs 332
410153 BE311926 Hs 15830 Homo sapiens cDNA FU12691 fis. clone NT 33 1
424871 NM 004525 Hs 153595 low density lipoprotein-related protein 328
420908 AL049974 Hs 100261 Homo sapiens mRNA, cDNA DKFZp564B222 (fr 324
423992 AW898292 Hs 137206 Homo sapiens mRNA, cDNA DKFZp564H1663 (f 324
451050 AW937420 Hs 69662 ESTs 320
449034 AI624049 gb ts41a09 1 NCI CGAP_Ut1 Homo sapiens 31 6
434539 AW748078 Hs 214410 ESTs 31 0
431595 AA508196 gb nh60f07 s1 NCI_CGAP.Pr8 Homo sapiens 306
449625 NM 014253 Hs 23796 odz (odd Oz/ten-m, Drosophila) homolog 1 305
448243 AW369771 Hs 77496 small nuclear πbonucleoprotein polypept 304
413573 AI733859 Hs 149089 ESTs 30 2
421037 AI684808 Hs 197653 ESTs 302
449353 AA001220 Hs 271369 ESTs 302
416548 H62953 gb yr47f06 r1 Soares fetal liver spleen 296
423020 AA383092 Hs 1608 replication protein A3 (14kD) 296
422420 U03398 Hs 1524 tumor necrosis fxtor (ligand) superfami 296
459508 R83265 Hs 205956 ESTs 292
414245 BE148072 Hs 75850 WAS protein family, member 1 288
424565 AW102723 Hs 75295 guanylate cyclase 1 , soluble, alpha 3 286
445925 AI733820 Hs 145664 ESTs 284
412616 AW970584 Hs 291033 ESTs 280 424638 AI472106 Hs 49303 Homo sapiens cDNA FU 11663 fis clone HE 276
445885 AI734009 Hs 127699 KIAA1603 protein 276
410247 AF181721 Hs 61345 RU2S 274
406414 27 2
435951 AF269162 Hs 41267 c21orf7 form A-D 27 2
458680 N73773 Hs 282950 ESTs 270
419948 AB041035 Hs 93847 NADPH oxidase 4 264
423276 AC003034 Hs 126261 Homo sapiens Chromosome 16 BAC done CIT 263
427457 AW779105 Hs 164682 ESTs, Weakly similar to ORF2 consensus s 260
446346 AI290205 gb ql79g06 x1 Soares.NhHMPu.S1 Homo sapi 260
448595 AB014544 Hs 21572 KIAA0644 gene product 258
419569 AI971651 Hs 91143 jagged 1 (Alagille syndrome) 256
433242 AB040938 Hs 113940 KIAA1505 protein 256
453118 AW195849 Hs 252757 ESTs 256
412209 AW901456 gb RCO-NN1012-270300-031-C07 NN1012 Homo 252
429710 AI337113 Hs 146025 Homo sapiens cDNA FU23594 fis, clone L 252
444783 AK001468 Hs 62180 anillin (Drosophila Scraps homolog), xt 246
436788 AA766908 Hs 259047 ESTs 244
427660 AI741320 Hs 114121 Homo sapiens cDNA FU23228 fis, clone C 244
419172 AW338625 Hs 22120 ESTs 24 3
436061 AI248584 Hs 190745 Homo sapiens cONA FU21326 fis, done C 242
413623 AA825721 Hs 246973 ESTs 240
407615 AW753085 gb PM1-CT0247-151299-005-303 CT0247 Homo 238
452466 N84635 Hs 29664 Human DNA sequence from clone 682J15 on 238
432809 AA565509 Hs 131703 ESTs 237
440102 AI672443 Hs 131190 ESTs 236
451559 AL119980 Hs 128857 ESTs 23 2
410811 AW805687 Hs 300648 ESTs 230
416778 M16505 Hs 79876 steroid sulfatase (microsomal), arylsulf 230
453628 AW243307 Hs 170187 ESTs 22 8
401352 226
451561 N52812 Hs 177403 ESTs 226
401976 224
410658 AW105231 Hs 192035 ESTs 224
416220 N49776 Hs 121773 ESTs 222
424073 U03493 Hs 138959 gap junction protein, alpha 7, 45kD (con 22 0
444575 AI264847 Hs 22545 Homo sapiens cDNA FU 12935 fis, clone NT 220
444144 BE159397 Hs 7736 hypothedcal protein 21 8
438504 AW665281 Hs 224625 ESTs 21 2
439157 AA912737 Hs 20160 ESTs 208
429006 AA443143 Hs 50929 Homo sapiens cDNA FLJ13842 fis, clone TH 20 5
442006 AW975183 Hs 292663 ESTs 20 2
409569 AW573153 Hs 256216 ESTs 19 8
421160 AL080215 Hs 102301 Homo sapiens mRNA, cDNA DKFZp586J0323 (f 198
404200 196
446591 H44186 Hs 15456 PDZ domain containing 1 19 2
420218 AW958037 Hs 22437 Homo sapiens cDNA FU23366 fis, clone H 18 9
408390 AA054222 Hs 40400 ESTs 188
444038 AW134509 Hs 135077 ESTs 188
446443 AV659082 Hs 134228 ESTs 188
442204 AI635450 Hs 21914 ESTs 184
451177 AI969716 Hs 13034 ESTs 18 2
453931 AL121278 Hs 25144 ESTs 18 1
437212 AI765021 Hs 210775 ESTs 18 1
431806 AF186114 Hs 270737 tumor necrosis fxtor (ligand) superfami 180
451659 BE379761 Hs 14248 ESTs, Weakly similar to ALU8.HUMAN ALU S 178
423909 AJ223183 Hs 135194 immunoglobulin superfamily, member 6 17 6
441082 AW444804 Hs 202655 ESTs 176
446259 AA425204 Hs 42278 Homo sapiens cDNA FU13391 fis, clone PL 176
423609 AA328348 Hs 218289 ESTs 174
428301 AW628666 Hs 98440 ESTs 17 4
446364 AB006624 Hs 14912 KIAA0286 protein 174
419983 W55956 Hs 94030 Homo sapiens mRNA, cDNA DKFZp586E1624 (f 170
424929 AI640761 Hs 224988 ESTs 17 0
425695 NM 005401 Hs 159238 protein tyrosine phosphatase, non recept 170
449122 AI631310 Hs 196955 ESTs 170
409519 AA075368 gb zm86h10 r1 Stratagene ovanan cancer 168
410947 AK000305 Hs 67055 hypothetical protein FU20298 16 8
418053 AA211493 gb zn55d06 s1 Stratagene muscle 937209 H 168
433225 AW816515 Hs 173540 ATPase, Class V, type 10D 16 8
443204 AW205878 Hs 29643 Homo sapiens cDNA FU13103 fis, clone NT 166
421002 AF116030 Hs 100932 transcπption fxtor 17 16 5
419296 AA236115 Hs 120785 ESTs 16 2
421659 NM 014459 Hs 106511 protocadheπn 17 160
417589 T82075 Hs 13911 ESTs 160
446057 AI420227 Hs 149358 ESTs 158
434636 AA083764 Hs 241334 ESTs 15 6
446797 AI682536 Hs 163495 Homo sapiens cDNA FU 13608 fis, clone PL 156
443718 AI083580 Hs 221373 ESTs 154
409748 AI670776 Hs 20961 ESTs 152
443211 AH 28388 Hs 143655 ESTs 150
428911 Z43846 Hs 194478 Homo sapiens mRNA, cDNA DKFZp43401572 (f 149
444692 AW779922 Hs 145047 ESTs 14 8 445436 AI224105 Hs 151408 ESTs 146
408684 R61377 Hs 12727 hypothedcal protein FU21610 145
405943 144
406291 144
458679 AW975460 Hs 143563 ESTs 144
450152 AI138635 Hs 22968 ESTs 144
403899 14 2
454490 AW797778 gb CM2-UM0041-250200-104-d02 UM0041 Homo 14 2
451807 W52854 Hs 27099 DKFZP564J0863 protein 140
452453 AI902519 gb QV-BT009-101198-051 BT009 Homo sapien 138
447499 AW262580 Hs 147674 KIAA1621 protein 138
406598 136
430939 AI269471 Hs 187018 ESTs 134
443316 AI478463 Hs 18443 ESTs 13,4
408034 N26639 Hs 42192 Human EST clone 251800 manner transposo 132
428508 BE252383 Hs 184668 SBBI31 protein 132
447934 AW631440 Hs 165596 ESTs 132
406671 AA129547 Hs 285754 met proto-oncogene (hepatocyte growth fa 131
438199 AW016531 Hs 122147 ESTs 130
415511 AI732617 Hs 182362 ESTs 129
426920 AA393351 Hs 132121 ESTs 128
447311 R37010 Hs 33417 Homo sapiens cDNA FU22806 fis, ctone K 126
423321 AB013885 Hs 126926 beta-ureidopropionase 125
403622 124
439759 AL359055 Hs 67709 Homo sapiens mRNA full length insert cDN 124
422317 NM 001147 Hs 115181 angiopoiedn 2 122
428637 AW979268 gb EST391378 MAGE resequences, MAGP Homo 122
445717 AW664658 Hs 149332 ESTs 122
418413 R95735 Hs 117753 ESTs, Weakly similar to andgen of the m 12 1
405336 120
437100 AI761073 Hs 14535 Homo sapiens cDNA FU22314 (is, clone H 120
428227 AA321649 Hs 2248 small inducible cytokine subfamily B (Cy 120
414923 AW445008 Hs 77637 homeo box A4 11 9
432009 AL137424 gb Homo sapiens mRNA, cDNA DKFZp761G2123 11 8
433326 AI379486 Hs 159430 ESTs 11 8
453955 AW579207 gb RC1-DT0029-120100-011- 01 DT0029 Homo 11 8
407510 U96191 gb Human trophoblast hypoxia-regulated f 11 6
433231 AB040926 Hs 143552 KIAA1493 protein 11 6
451651 AI097337 Hs 88977 hypothetical protein dJ511E162 11 6
443672 AA323362 Hs 9667 butyrobetane (gamma), 2-oxoglutarate di 11 4
405609 11 4
418912 NM 000685 Hs 89472 angiotensm receptor 1 11 4
421306 AA806207 Hs 125889 ESTs 11 4
428721 X02158 Hs 2303 erythropoietin 11 4
419255 AA235672 Hs 87491 ESTs 11 4
450006 AI241555 Hs 60171 ESTs 11 3
435420 A1928513 Hs 59203 ESTs 11 2
449802 AW901804 Hs 23984 hypothedcal protein FU20147 11 2
424647 W67751 Hs 137308 ESTs 11 0
435758 AI242163 Hs 22670 chromodomain helicase DNA binding protei 11 0
404347 108
438664 AI911173 Hs 213722 ESTs 10 8
429125 AA446854 Hs 271004 ESTs 107
416560 R02818 Hs 14102 ESTs 106
429945 NM 006729 Hs 226483 diaphanous (Drosophila homolog) 2 106
435085 AW130284 Hs 192752 ESTs, Moderately similar to NSD1 protein 106
442409 BE208843 Hs 129544 ESTs, Weakly similar to ORF YLL027w [S c 106
450644 AW505496 Hs 281215 ESTs 106
448298 AW137134 Hs 187203 ESTs 104
404115 102
406242 10 2
420757 X78592 Hs 99915 androgen receptor (dihydrotestosterone r 102
452588 AA889120 Hs 110637 homeo box A10 10 2
457233 AI355009 Hs 221698 ESTs 102
416185 AW975861 Hs 291995 ESTs 102
446152 AI292036 Hs 150028 ESTs 101
446298 AF187813 Hs 14637 kidney- and liver-specific gene 101
423637 AL137279 Hs 130187 Homo sapiens mRNA, cDNA DKFZp43401214 (f 100
442405 BE465247 Hs 129530 ESTs 99
419213 AW7491 6 gb PMO-BT0340-170100-004-e03 BT0340 Homo 98
420840 AI915836 Hs 294008 ESTs 98
423355 AA324856 Hs 257510 ESTs 98
444929 AI685841 Hs 161354 ESTs 98
423811 AW299598 Hs 50895 homeo box C4 98
433527 AW235613 Hs 133020 ESTs 96
429975 AI167145 Hs 165538 ESTs 96
439979 AW600291 Hs 6823 hypothedcal protein FU10430 95
433703 AA210863 Hs 3532 nemo-like kinase 92
417404 NM 007350 Hs 82101 pleckstnn homology like doman, family 92
451621 AI879148 Hs 26770 fatty xid binding protein 7, brain 92
406992 S82472 gb beta -pol=DNA polymerase beta (exon a 92
419699 AA248998 Hs 31246 ESTs 92
443740 R56434 Hs 21062 ESTs 92 422728 AW937826 Hs 103262 ESTs 92
436961 AW375974 Hs 156704 ESTs 92
431385 BE178536 Hs 11090 high affinity immunoglobulin epsilon rec 9 1
411411 AA345241 Hs 55950 ESTs, Weakly similar to KIAA1330 protein 9 1
424115 AA335497 Hs 293965 ESTs 90
402045 90
433426 H69125 Hs 133525 ESTs 90
425493 AW363582 Hs 75323 prohibidn 90
447641 BE619186 gb 601472933F1 NIH.MGC .68 Homo sapiens c 90
403095 88
407942 AA378608 Hs 5894 hypothedcal protein FLJ 10305 88
423126 AA322245 Hs 290165 ESTs 88
408134 AK000184 Hs 42945 xid sphingomyelmase-like phosphodieste 87
450375 AA009647 Hs 8850 a dismtegnn and metalloproteinase doma 86
443647 AV653846 Hs 126261 Homo sapiens Chromosome 16 BAC clone CIT 86
401439 86
449532 W74653 Hs 271593 ESTs 86
453197 AI916269 Hs 109057 ESTs. Weakly similar to ALU5_HUMAN ALU S 86
448450 BE612490 gb 601451884F1 NIH_MGC_66 Homo sapiens c 85
425176 AW015644 Hs 301430 ESTs. Moderately simila to TEF1.HUMAN T 84
407721 Y12735 Hs 38018 dual-specificity tyrosιne-(Y)-phosphorγl 84
402921 84
428133 AW167727 Hs 11873 ESTs 84
419503 AA243642 Hs 137422 ESTs 84
452644 AW452616 Hs 212481 ESTs 84
452259 AA317439 Hs 28707 signal sequence receptor, gamma (translo 84
409695 AA296961 gb EST112514 Adrenal gland tumor Homo sa 83
418076 R61388 Hs 6724 ESTs 83
402696 83
423099 NM.002837 Hs 123641 protein tyrosine phosphatase, receptor t 83
413998 AW103807 Hs 243933 ESTs 82
410008 AA079552 gb zm20h12 s1 Stratagene pancreas (93720 82
416623 N74925 Hs 38761 Homo sapiens cDNA FU21564 fis, clone C 82
450001 NM 001044 Hs 406 solute earner family 6 (neurotransmitte 8 1
435496 AW840171 Hs 265398 ESTs Weakly similar to transformadoπ-r 80
413627 BE182082 Hs 246973 ESTs 80
415713 AW968573 gb EST380649 MAGE resequences, MAGJ Homo 80
426695 AW118191 Hs 112729 ESTs 80
452284 AW451426 Hs 252740 ESTs 80
454933 BE141714 gb QV0-HT0101 061099-032-c04 HT0101 Homo 80
426269 H15302 Hs 168950 Homo sapiens mRNA, cDNA DKFZp566A1046 (f 80
418882 NM 004996 Hs 89433 ATP-bmding cassette, sub-family C (CFTR 80
444107 T46839 Hs 10319 UDP glycosyltransferase 2 family, polype 79
445740 T78281 Hs 13226 Homo sapiens clone 25181 mRNA sequence 79
433190 M26901 Hs 3210 renin 78
432777 AA564991 Hs 269477 ESTs 78
449444 AW818436 Hs 23590 solute earner family 16 (monocarboxylic 77
444042 NM 004915 Hs 10237 ATP-b ding cassette, sub-family G (WHIT 77
434032 AW009951 Hs 206892 ESTs 77
419750 AL079741 Hs 183114 Homo sapiens cDNA FU 14236 fis, clone NT 76
439024 R96696 Hs 35598 ESTs 76
437205 AL110232 gb Homo sapiens mRNA, cDNA DKFZp564D2071 74
446030 AF131805 Hs 13544 Homo sapiens clone 24850 mRNA sequence 74
446311 AW007294 Hs 149795 ESTs Weakly similar to ALU 1 HUMAN ALU S 74
452883 X80031 Hs 150318 ESTs 74
448253 H25899 Hs 201591 ESTs 74
406030 74
437084 AI911516 Hs 127811 ESTs 73
435013 H91923 Hs 110024 NADH ubiquinone oxidoreductase MLRO subu 73
432143 AL040183 Hs 123484 ESTs Weakly similar to The KIAA0149 gen 73
409594 AA076118 gb zm18e06 s1 Stratagene pancreas (93720 72
425151 AA351814 Hs 298678 ESTs 72
448582 AI538880 Hs 94812 ESTs 72
455068 AI807894 Hs 27910 cendosomal protein 2 7 2
406504 72
428395 AA427992 Hs 104885 ESTs Weakly similar to zinc finger prot 72
421102 AI470093 Hs 89217 ESTs 72
423161 AL049227 Hs 124776 Homo sapiens mRNA, cDNA DKFZp564N1116 (f 71
410534 AW905138 gb QV0-NN1071-28040O-2O7-g07 NN1071 Homo 7 1
415084 M19267 Hs 77899 tropomyosin 1 (alpha) 70
410274 AA381807 Hs 61762 hypoxia-mducible protein 2 70
439416 W58294 Hs 56254 ESTs 69
420036 R60336 Hs 52792 Homo sapiens mRNA, cDNA DKFZp586l1823 (f 68
423349 AF010258 Hs 127428 homeo box A9 68
413070 AA126776 gb zπ88c11 s1 Stratagene lung carcinoma 68
449361 AW207890 Hs 201918 ESTs 68
459309 AA040620 Hs 109144 ESTs 68
408771 AW732573 Hs 47584 potassium voltage-gated channel, delayed 68
416462 W92845 gb zh80f05 r1 Soares fetal liver spleen 68
447835 AW591623 Hs 164129 ESTs 67
403563 67
427897 NM_017413 Hs 181060 apelm, peptide ligand for APJ receptor 66
422063 BE156476 gb QVO-HT0368-040100-082-C05 HT0368 Homo 66 455275 AW977806 gb EST389810 MAGE resequences, MAGO Homo 66
441350 AB020690 Hs 7782 paraneoplasdc andgen MA2 66
445575 Z25368 Hs 172004 ddn 66
446075 AW451457 Hs 279179 ESTs 66
405963 66
423049 X59373 Hs 188023 ESTs 66
436456 AW292677 Hs 65909 ESTs 65
420273 AI652864 Hs 197257 ESTs 65
420831 AA280824 Hs 190035 ESTs 64
423739 AA398155 Hs 97600 ESTs 64
441559 AA938448 Hs 259733 ESTs 64
433999 AA778212 Hs 191869 ESTs 64
439703 AF086538 Hs 196245 ESTs 64
433757 AI949974 Hs 152670 ESTs 63
422095 AI868872 Hs 288966 ceruloplasmin (feπoxidase) 63
415138 C18356 Hs 78045 dssue fxtor pathway inhibitor 2 63
448515 H68441 Hs 13528 Homo sapiens cDNA FU 14054 fis clone HE 63
443595 AF169312 Hs 9613 PPAR(gamma) angiopoiedn related protein 63
429357 AA779725 Hs 164589 ESTs 63
404939 63
417071 N58820 Hs 275133 ESTs 62
436209 AW850417 Hs 254020 ESTs, Moderately similar to unnamed prot 62
403111 62
448796 AA147829 Hs 33193 ESTs, Highly simila to AC0072283 BC372 62
442353 BE379594 Hs 49136 ESTs 62
451110 AI955040 Hs 301584 ESTs 61
420092 AA814043 Hs 88045 ESTs 61
441801 AW242799 Hs 211874 ESTs 60
407500 U43279 gb Human nucleopoπn nup 36 mRNA, comple 60
450864 R64139 Hs 205225 ESTs 60
455711 BE069465 gb RC2-BT0388-290100-012-a11 BT0388 Homo 60
405394 60
436476 AA326108 Hs 53631 ESTs, Weakly similar to enhancer-of-spli 60
454392 BE260893 gb 601150677F1 NIH MGC 19 Homo sapiens c 60
414575 H11257 Hs 295233 ESTs 59
435767 H73505 Hs 117874 ESTs 59
445495 BE622641 Hs 38489 ESTs 59
428372 AK000684 Hs 183887 hypothetical protein FU22104 59
436464 AI016176 Hs 269783 ESTs, Weakly similar to ALU1JHUMAN ALU S 59
415910 U20350 Hs 8913 chemokine (C-X3-C) receptor 1 59
402421 58
417038 T85230 gb yd33f02 r1 Soares fetal liver spleen 58
436461 AW511956 Hs 293261 ESTs 58
440870 AI687284 Hs 150539 Homo sapiens cDNA FU 13793 fis, ctone TH 58
452281 T9350O Hs 28792 Homo sapiens cDNA FU11041 fis clone PL 58
417280 AW173116 Hs 262206 ESTs 57
437259 AI377755 Hs 120695 ESTs 57
425717 X07282 Hs 171495 retinoic xid receptor, beta 57
443614 AV655386 Hs 7645 fibnnogen, B beta polypeptide 57
450625 AW970107 gb EST382188 MAGE resequences, MAGK Homo 56
425305 AA363025 Hs 155572 Human clone 23801 mRNA sequence 56
430371 087466 Hs 240112 KIAA0276 protein 56
430499 AW969408 Hs 231991 ESTs 56
427920 Z11502 Hs 181107 annexin A13 56
449318 AW236021 Hs 108788 ESTs Weakly similar to zeste [D melanog 56
407864 AF069291 Hs 40539 chromosome 8 open reading frame 1 55
410754 T63840 gb yc16b10 s1 Stratagene lung (937210) H 55
415286 AW249540 Hs 72548 ESTs 55
443297 AI049864 Hs 133029 ESTs 55
440138 AB033023 Hs 6982 hypothetical protein FLJ10201 55
441006 AW605267 Hs 7627 CGI 60 protem 54
409348 AI401535 Hs 146090 ESTs 54
449679 AI823951 Hs 296668 Homo sapiens cDNA FU 11846 fis, clone HE 54
408938 AA059013 Hs 22607 ESTs 54
456411 AA603305 gb np12d11 s1 NCI CGAP Pr3 Homo sapiens 54
443756 AW089799 Hs 153665 ESTs 54
422232 043945 Hs 113274 transcnpdon fxtor EC 54
424574 BE408618 Hs 150748 malonyl-CoA decarboxylase 53
424834 AK0O1432 Hs 153408 Homo sapiens cDNA FU10570 fis, clone NT 53
440589 BE397763 Hs 194478 Homo sapiens mRNA, cDNA DKFZp43401572 (f 53
425782 U66468 Hs 159525 cell growth regulatory with EF-hand doma 53
450236 AW162998 Hs 24684 KIAA1376 protein 53
418110 R43523 Hs 217754 Homo sapiens cON A FU 22202 fis, ctone H 53
427061 AB032971 Hs 173392 KIAA1145 protein 53
413841 M34276 Hs 75576 plasminogen 53
432358 AI093491 Hs 72830 ESTs 52
416805 F13271 Hs 79981 Human clone 23560 mRNA sequence 52
438475 W03856 Hs 13188 ESTs. Highly similar to Gene product wit 52
443305 AI050693 Hs 133318 ESTs 52
413930 M86153 Hs 75618 RA811 A. member RAS oncogene family 51
451859 H44491 Hs 252938 ESTs, Weakly similar to ALU1 HUMAN ALU S 51
429826 N93266 Hs 40747 ESTs 51
436032 AA150797 Hs 109276 latexin protein 51 447081 Y13896 Hs 17287 potassium inwardly rectifying channel s 5 1
438297 AW515196 Hs 258238 ESTs, Moderately similar to ALU1.HUMAN A 5 1
421126 M74587 Hs 102122 insulin-like growth fxtor binding prote 5 1
440238 AW451970 Hs 155644 paired box gene 2 5 1
426651 AU076646 Hs 171683 nuclear receptor subfamily 1, group H, m 50
425813 AA364136 Hs 210553 ESTs, Weakly similar to hypothedcal pro 50
432328 AI572739 Hs 195471 6-phosphofructo-2-kinase/fructose-2,6-bi 50
430682 AW971949 Hs 291252 ESTs 50
410049 AW579475 gb RCO-DT0076-110100-031-d10 DT0076 Homo 50
429222 AI457692 Hs 99164 ESTs 50
446317 AI287367 Hs 150906 ESTs 50
409506 NM 006153 Hs 54589 NCK adaptor protein 1 50
407768 AW002841 Hs 29475 ESTs 50
437938 AI950087 gb wq05c02 x1 NCI_CGAP_Kιd12 Homo sapien 50
430403 AF039390 Hs 241382 tumor necrosis fxtor (ligand) superfami 49
426215 AW963419 Hs 155223 stanniocalcm 2 49
448570 AI923944 Hs 30913 ESTs 49
445034 AW293376 Hs 160323 ESTs 49
410361 BE391804 Hs 62661 guanylate binding protein 1, interferon- 48
453891 AB037751 Hs 36353 Homo sapiens mRNA full length insert cDN 48
438492 AW340048 Hs 293188 ESTs 48
446417 AI299050 gb qn14d12 x1 NCI_CGAP_Lu5 Homo sapiens 48
409578 BE041386 gb hk88c02 x1 NCI_CGAP_Lu21 Homo sapiens 48
447269 NM 004861 Hs 17958 cεrebroside (3'-phosphoadenylylsulfate g 48
413795 AL040178 Hs 142003 ESTs 48
422357 AF016272 Hs 115418 cadheπn 16, KSP-cadheπn 48
452208 AA024792 Hs 31895 ESTs, Weakly similar to B9 [H sapiens] 47
422711 D60641 Hs 21739 Homo sapiens mRNA, cDNA DKFZp586H518 (f 47
441392 AW451831 Hs 222119 ESTs, Weakly similar to K1CQ HUMAN KERAT 47
439221 AA737106 Hs 32250 ESTs 47
431956 AK0O2032 Hs 272245 Homo sapiens cDNA FU11170 fis, clone PL 47
417355 D13168 Hs 82002 endothelin receptor type B 47
414700 H63202 Hs 38163 ESTs 47
402739 46
403170 46
443486 NM 003428 Hs 9450 zinc finger protein 84 (HPF2) 46
408380 AF123050 Hs 44532 diubiquidn 46
427899 AA829286 Hs 181062 serum amyloid A1 45
446302 AI285848 Hs 149757 ESTs 45
414812 X72755 Hs 77367 monokme induced by gamma interferon 44
424063 NM 002019 Hs 138671 fms-related tyrosine kinase 1 (vascular 44
413384 NM 000401 Hs 75334 exostoses (muldple) 2 44
421298 AWΪ72431 Hs 13012 ESTs 44
420789 AI670057 Hs 199882 ESTs 44
453558 AI417023 Hs 40478 ESTs 44
453745 AA952989 Hs 63908 Homo sapiens HSPC316 mRNA, partial eds 44
451762 AF222980 Hs 26985 disrupted in schizophrenia 1 44
410334 AW979261 Hs 291993 ESTs 44
457030 AI301740 Hs 173381 dihydropynmidinase-like 2 44
452194 AI694413 Hs 298262 ESTs Weakly similar to dJ88J8 1 [H sapi 43
410407 X66839 Hs 63287 carbonic anhydrase IX 43
401157 43
432004 BE018302 Hs 2894 plxental growth fxtor, vascular endoth 43
426866 U02330 Hs 172816 neuregulm 1 43
446115 AI733075 Hs 292682 ESTs, Weakly similar to S69913 hypertens 43
424704 AI263293 Hs 152096 cytochrome P450, subfamily IIJ (arxhido 42
446619 AU076643 Hs 313 secreted phosphoprotein 1 (osteopondn 42
433578 BE336886 Hs 3416 adipose differentiation-related protein 42
407065 Y10141 gb H sapiens DAT1 gene, partial, VNTR 42
407182 AA312551 Hs 230157 ESTs 42
416565 AW000960 Hs 44970 ESTs 42
442230 BE219088 Hs 279547 ESTs 42
440680 AA903098 gb ok46f08s1 NCI CGAP Leι2 Homo sapiens 42
413802 AW964490 Hs 32241 ESTs 42
438370 AA843242 Hs 48523 ESTs 42
432731 R31178 Hs 287820 fibronectin 1 42
409745 AA077391 gb 7B14E12 Chromosome 7 Fetal Bran cDNA 42
441484 AA935481 Hs 58972 ESTs 42
411213 AA676939 Hs 69285 neuropilin 1 42
453045 AW418979 Hs 224502 ESTs 42
407999 AI126271 Hs 49433 ESTs, Weakly simila to HYPOTHETICAL PRO 42
409770 AW499536 gb UI-HF-BR0p-a|i-c-12-0-UI r1 NIH MGC 5 4 1
449856 AA203155 Hs 18200 ESTs 4 1
430806 S69377 Hs 247978 T-cell xute lymphocydc leukemia 2 4 1
412872 BE006341 gb RC2-B N0127-240300-011 -b05 BN0127 Homo 4 1
430719 AA488988 Hs 293796 ESTs 4 1
409637 AA323948 Hs 55407 Homo sapiens mRNA, cDNA DKFZp434K0621 (f 4 1
414696 AF0O2020 Hs 76918 Niemann-Pick disease, type C1 4 1
444670 H58373 Hs 37494 ESTs 4 1
448090 AI608821 Hs 270289 ESTs 4 1
408830 AK001709 Hs 48403 hypothetical protein FU 10847 4 1
419088 AI538323 Hs 77496 small nuclear nbonucleoprotein polypept 4 1
416655 AW968613 Hs 79428 BCL2/adenovιrus E1B 19kD-ιnterxdng pro 4 1 436772 AW975688 Hs 250867 zona pellucida glycoprotein 3A (sperm re 4 1
442556 AL137761 Hs 8379 Homo sapiens mRNA, cDNA 0KFZp586L2424 (f 41
459595 AL040421 gb DKFZp434B0714_r1 434 (synonym htes3) 4 1
438859 AI559626 Hs 164973 ESTs, Weakly similar to AF231024 1 proto 40
423279 AW959861 Hs 290943 ESTs 40
441592 AW137071 Hs 127211 ESTs 40
411836 AW901879 gb QVO-NN1021-280400-212-f10 NN1021 Homo 40
426384 AI472078 gb t|85h03 x1 Soares.NSF.F8_9W_OT_PA_P.S 40
412494 AL133900 Hs 792 ADP-πbosyladon fxtor do an protein 1 40
413583 AL120806 Hs 5888 ESTs 40
415610 L44319 gb HUMEST1D10 Human thymus NSTH II Homo 40
430009 AA894564 Hs 22242 ESTs 40
449539 W80363 Hs 58446 ESTs 40
438929 AW195515 Hs 253177 ESTs 40
416000 R82342 Hs 79856 ESTs 40
429616 AI982722 Hs 120845 ESTs 40
458471 AV648609 Hs 194240 ESTs 40
453195 BE241876 Hs 32352 hypothedcal protein DKFZp434K1210 40
459046 AA910339 Hs 26216 Homo sapiens cDNA FU22811 fis, done K 39
438177 BE327015 Hs 281391 ESTs 39
422438 AA445925 Hs 270896 ESTs 39
450382 AA397658 Hs 60257 Homo sapiens cDNA FU13598 fis, clone PL 39
449611 AI970394 Hs 197075 ESTs 39
452030 AL137578 Hs 27607 Homo sapiens mRNA cDNA DKFZp564N2464 (f 39
452881 AW135220 Hs 241921 ESTs 39
414729 BE466928 Hs 281901 ESTs 39
428816 AA004986 Hs 193852 ATP-bindmg cassette, sub-family C (CFTR 39
405908 38
445452 H92975 Hs 246046 ESTs, Weakly simila to RET1 HUMAN RETIN 38
447961 W32791 Hs 170405 ESTs 38
446639 AI016826 Hs 132501 ESTs 38
401189 38
429548 AW138872 Hs 135288 ESTs 38
431523 N55759 Hs 163674 ESTs 38
430014 H59354 Hs 182485 xdnm, alpha 4 38
429250 H56585 Hs 198308 tryptophan πch basic protein 38
451988 AF263928 Hs 27410 papillomavirus regulatory fxtor PRF-1 38
437939 AW298600 Hs 141840 ESTs, Weakly similar to S59501 interfero 38
427510 Z47542 Hs 179312 small nuclear RNA xtivadng complex, po 38
433522 AI821730 Hs 116524 ESTs 38
443843 AW878864 Hs 13528 Homo sapiens cDNA FU14054 fis, clone HE 37
407305 AA715284 gb nv35f03 r1 NCI.CGAP Br5 Homo sapiens 37
434613 AI821826 Hs 187786 ESTs, Moderately similar to ALUB HUMAN ' 37
410276 AI554545 Hs 68301 ESTs 37
422504 AA311407 gb EST182167 Jurkat T-cells V Homo sapie 37
421013 M62397 Hs 1345 mutated in colorectal cancers 37
437949 U78519 Hs 41654 ESTs 37
431840 AA534908 Hs 2860 POU doman, class 5, transcnpdon fxto 37
409446 AI561173 Hs 67688 ESTs 37
415263 AA948033 Hs 130853 ESTs 37
450206 AI796450 Hs 201600 ESTs 37
439444 AI277652 Hs 54578 ESTs 37
437828 AW976806 Hs 291805 ESTs 37
453238 AA033991 Hs 269234 ESTs 37
420041 AB005142 Hs 94592 klotho 37
448458 AW614367 Hs 171054 ESTs 37
435080 AI831760 Hs 155111 ESTs 37
444249 T87398 Hs 205816 ESTs 37
426595 AW971980 Hs 62402 p21/Cdc42/Rx1-xtιvated kinase 1 (yeast 37
417715 AW969587 Hs 86366 ESTs 37
432579 AF043244 Hs 278439 nucleolar protein 3 (apoptosis repressor 36
440048 AA897461 Hs 158469 ESTs Weakly similar to envelope protein 36
430091 AB032958 Hs 233023 KIAA1132 protein 36
438030 X98427 Hs 122634 ESTs 36
453496 AA442103 Hs 33084 solute carrier family 2 (facilitated glu 36
446636 AC002563 Hs 15767 citron (rho-interxting, seππe/threonin 36
417860 AW408557 Hs 235498 Homo sapiens cDNA FU14075 fis clone HE 36
435794 H72108 Hs 13704 ESTs 36
449695 AA164569 Hs 34550 ESTs 36
411485 AW848125 gb IL3-CT0214-301299-048-GO4 CT0214 Homo 36
426274 D38122 Hs 2007 tumor necrosis fxtor (ligand) superfami 36
458201 AI989961 Hs 233477 ESTs, Moderately similar to A Chain A, S 36
440987 AA911705 Hs 130229 ESTs 36
425178 H16097 Hs 161027 ESTs 36
419080 AW150835 Hs 18878 hypothetical protein FU21620 36
436091 AA704705 Hs 181044 ESTs Weakly simila to A Chan A, Human 36
452671 AW861074 Hs 225833 ESTs 36
437222 AL117588 Hs 299963 ESTs 36
437809 AL137723 Hs 5855 Homo sapiens mRNA cDNA DKFZp434D0818 (f 35
411545 AW850818 gb IL3-CT0220-091199-026-A03 CT0220 Homo 35
414799 AI752416 Hs 77326 insulin-like growth fxtor binding prote 35
439882 AA847856 Hs 124565 ESTs 35
419229 AI827237 Hs 282884 ESTs 35 431889 AA521277 Hs 124946 ESTs 35
422660 AW297582 Hs 237062 ESTs 35
415122 D60708 Hs 22245 ESTs 35
444127 N63620 Hs 13281 ESTs 35
416913 AW934714 gb RC1-DT0001-031293-011 -a11 DT0001 Homo 35
409044 AI129586 Hs 33033 ESTs 35
453365 AA035211 Hs 17404 ESTs 35
452355 N54926 Hs 29202 G protein-coupled receptor 34 35
423246 AL119114 Hs 23107 ESTs 35
434131 AI858275 Hs 143659 ESTs 35
425304 AA463844 Hs 31339 fibroblast growth fxtor 11 35
453775 NM 002916 Hs 35120 replication fxtor C (xdvator 1) 4 (37 34
426559 AB001914 Hs 170414 paired basic ammo xid cleaving system 34
456311 AA225632 Hs 190016 ESTs 34
420737 L08096 Hs 99899 tumor necrosis fxtor (ligand) superfami 34
448733 NM.005629 Hs 187958 solute earner family 6 (neurotransmitte 34
401811 34
404021 34
447175 AI365208 Hs 293606 ESTs 34
453743 AL120480 gb DKFZp761K098_r1 761 (synonym hamy2) 34
455070 AW854675 gb MR1-CT0258-290300-206-a01 CT0258 Homo 34
419546 AA244199 gb nc06c05 s1 NO CGAP PM Homo sapiens 34
449441 AI656040 Hs 196532 ESTs 34
441606 R37263 Hs 21065 ESTs 34
446594 AI311917 Hs 16292 ESTs 34
424664 AI432572 Hs 164221 ESTs 34
413719 BE439580 Hs 75498 small inducible cytokine subfamily A (Cy 34
427914 AA417350 Hs 20575 ESTs 34
438257 AW474419 Hs 224794 ESTs 34
412642 BE244598 Hs 809 hepatocyte growth fxtor (hepapoiedπ A, 34
454690 AW854639 gb MR1-CT0258-140100-203-d10 CT0258 Homo 33
428046 AW812795 Hs 155381 ESTs, Moderately simila to 138022 hypot 33
407331 AI570416 Hs 99910 phosphofructokinase, platelet 33
440472 AA886169 Hs 169071 ESTs 33
421893 NM_001078 Hs 109225 vascular cell adhesion molecule 1 33
403797 33
417924 AU077231 Hs 82932 cyclin D1 (PRAD1 parathyroid adenomatos 33
410623 AW958932 Hs 293833 ESTs 33
449338 H73444 Hs 394 adrenomedullin 33
441024 AW081530 Hs 137088 ESTs 33
405257 33
450396 AU077002 Hs 24950 regulator of G-protem signalling 5 33
416892 L24498 Hs 80409 growth aπest and DNA-damage-mducible, 33
444471 AB020684 Hs 11217 KIAA0877 protein 33
431689 AA305688 Hs 267695 UDP-Gal betaGlcNAc beta 1,3-galxtosyltr 33
452093 AA447453 Hs 27860 Homo sapiens mRNA, cDNA DKFZp586M0723 (f 33
425236 AW067800 Hs 155223 stanniocalc 2 33
428824 W23624 Hs 173059 ESTs 32
450101 AV649989 Hs 24385 Human hbc647 mRNA sequence 32
425260 L47726 Hs 1870 phenylalanine hydroxylase 32
443830 AI142095 Hs 143273 ESTs 32
415245 N59650 Hs 27252 ESTs 32
405953 32
430812 L10405 Hs 247992 DNA binding protein for surfxtant prote 32
418946 AI798841 Hs 132103 ESTs 32
424750 D29956 Hs 152818 ubiquitin specific protease 8 32
435342 AW979168 Hs 163270 ESTs 32
458860 AW873557 Hs 212739 ESTs 32
430172 AA468591 Hs 161889 ESTs 32
431842 NM_005764 Hs 271473 epithelial protein up-regulated in carci 32
451221 AI949701 Hs 210589 ESTs 32
436211 AK001581 Hs 80961 polymerase (DNA directed), gamma 32
433727 C16221 Hs 112608 ESTs 32
424897 063216 Hs 153684 fπzzled-related protein 32
414821 M63835 Hs 77424 Fc fragment of IgG, high affinity la, re 3 1
418030 BE207573 Hs 83321 neuromedin B 31
417919 AI928203 Hs 86379 ESTs 3 1
430437 AI768801 Hs 169943 Homo sapiens cDNA FLJ 13569 fis, clone PL 3 1
409663 AI743750 Hs 65862 ESTs 3 1
454024 AA993527 Hs 16281 hypothedcal protein FU23403 3 1
424980 L42172 Hs 154078 lipopolysacchande-bindmg protein 3 1
421633 AF121860 Hs 106260 sorting nexin 10 3 1
436002 R68529 Hs 120967 ESTs 3 1
437682 AA476652 Hs 94952 Homo sapiens cDNA FU23371 fis, clone H 31
439451 AF086270 Hs 278554 heterochromatin-like protein 1 3 1
430183 BE010038 gb PM3-BN0176-100400-001-g04 BN0176 Homo 3 1
428479 Y00272 Hs 184572 cell division cycle 2, G1 to S and G2 to 3 1
441285 NM 002374 Hs 167 microtubule-associated protein 2 3 1
456386 W28481 gb 47e1 Human redna cDNA randomly pnme 31
451130 AI762250 Hs 211347 ESTs 3 1
439702 AW085525 Hs 134182 ESTs 3 1
453331 AI240665 Hs 8895 ESTs 3 1
428841 AI418430 Hs 104935 ESTs 3 1 449899 AI610700 Hs 103280 ESTs 3 1
436009 H57130 Hs 120925 ESTs 31
448966 AW37291 Hs 287462 Homo sapiens CDNA FU11875 fis clone HE 3 1
408239 AA053401 Hs 271827 ESTs Moderately similar to ALU7.HUMAN A 3 1
418526 BE019020 Hs 85838 solute earner family 16 (monocarboxylic 31
401260 3 1
450705 U90304 Hs 25351 iroquois-class homeodo an protein 31
447233 AW246333 Hs 17901 Homo sapiens cDNA FU21974 fis clone H 31
424415 NM_0O1975 Hs 146580 enolase 2, (gamma, neuronal) 30
403346 30
446319 AW207590 Hs 160711 ESTs 30
432757 AF113013 Hs 278919 PRO0806 protein 30
407921 AI378617 Hs 23100 Homo sapiens cDNA FU 12592 fis, ctone NT 30
414618 AI204600 Hs 96978 ESTs 30
434398 AA121098 Hs 3838 serum-inducible kinase 30
440113 AI916532 Hs 188272 ESTs 30
424539 L02911 Hs 150402 xdvin A receptor, type I 30
428945 AW192803 Hs 98974 ESTs 30
458297 R54033 Hs 21245 ESTs 30
424405 AI076838 Hs 12967 ESTs 30
411290 AW835544 gb QV4-LT0016-271299-068-f03 LT0016 Homo 30
459068 BE464396 Hs 118468 ESTs 30
459065 AI373532 Hs 157910 ESTs 30
437693 AI754443 Hs 185951 ESTs 30
429418 AI381028 Hs 99283 ESTs 30
406117 30
415492 R41674 Hs 16491 ESTs 30
419854 AW664873 Hs 87836 Homo sapiens PAC clone RP5-1087M19 from 30
453688 AW381270 Hs 194110 Homo sapiens mRNA, cDNA DKFZp434C0814 (f 30
408119 W26213 gb 22d 10 Human retina cDNA randomly pπm 30
438358 AL035992 Hs 210278 ESTs 30
412372 R65998 Hs 118615 ESTs 30
431984 AL080239 Hs 272284 Human DNA sequence from clone GS1-256022 30
403782 30
443183 R16258 Hs 6217 Homo sapiens cDNA FU12521 fis, clone NT 30
456388 W28557 gb 48d8 Human redna cDNA randomly pnme 30
447922 Z92910 Hs 20019 hemochromatosis 30
428857 AF008192 Hs 194283 putadve GR6 protein 30
406991 S82185 (NONE) 30
432596 AJ224741 Hs 278461 matπlin 3 30
453202 AW085781 Hs 26270 Homo sapiens cDNA FU11588 fis, clone HE 30
414132 AI801235 Hs 48480 ESTs 30
409122 W07089 Hs 297873 ESTs 30
405547 30
422219 AW978073 gb EST390182 MAGE resequences, MAGO Homo 30
417227 T57776 Hs 191094 ESTs 30
448592 N69546 Hs 141706 ESTs 30
421477 AI904743 Hs 104650 hypothedcal protem FU 10292 30
400368 BE779978 Hs 69149 prolme-senne-threonme phosphatase int 30
455362 AW902635 gb QV3-NN1024-100500-181-b02 NN1024 Homo 30
443578 R97191 Hs 134106 ESTs 30
419348 AA236645 Hs 98274 ESTs 30
439138 AI742605 Hs 193696 ESTs 30
449547 H93543 Hs 117963 ESTs 30
455180 AW863503 gb MR3-SN0009-180400 110-C12 SN0009 Homo 30
444228 AV648612 Hs 282396 ESTs 30
423496 U91963 Hs 129700 tolloid-like 1 30
401707 30
419276 BE165909 Hs 134682 Homo sapiens cDNA FU23161 fis, clone L 30
441677 AW271702 Hs 93739 ESTs 30
459587 AA031956 gb zk15e04 s1 Soares pregnant uterus NbH 30
431311 AA502552 Hs 188980 ESTs 30
426326 BE165753 Hs 250528 ESTs, Weakly similar to unnamed protein 30
412685 BE092186 gb IL2-BT0734-200400-075-H05 BT0734 Homo 30
414752 BE503505 Hs 248689 ESTs 30
403144 30
407539 X91103 gb H sapiens mRNA for Hr44 protein 30
412379 AW947581 gb RCO-MT0004-140300-031-d08 MT0004 Homo 30
407937 AW297944 Hs 242811 ESTs 30
456976 AI681882 Hs 270428 ESTs 30
417066 AA329572 Hs 172004 ddn 30
406007 30
416940 N75620 Hs 43157 ESTs 30
433322 H50621 Hs 134156 ESTs 30
406088 30
416573 R10356 Hs 18865 ESTs, Weakly similar to AC0072282 BC372 30
423130 AW897586 Hs 21213 ESTs 30
412721 AW183165 Hs 95600 ESTs 30
418375 NM 003081 Hs 84389 synaptosomal-associated protein, 25kD 30
422992 AF016833 Hs 122785 altase-glucoamylase (alpha-glucosidase) 30
406506 30
413472 BE242870 Hs 75379 solute earner family 1 (glial high affi 30
422650 D42055 Hs 1565 neural precursor cell expressed develop 30 400325 M85292 Hs 247924 Homo sapiens endogenous HIV-1 related se 30 401078 30 446645 AI336596 Hs 156294 ESTs 30 446704 AI337228 Hs 197083 ESTs 30 427072 H38046 gb yp58c 10 r1 Soares fetal liver spleen 30
TABLE 33B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT number Accession
407615 1005404.1 AW753085 AW753082 AW054744 AW753107 AW753087
408119 1040172 1 W26213 H08055244031 AW954559 R17434
409519 113722.1 AA075368 AA075369
409578 1140976.1 BE041386 AW419449 AW663595
409594 114249.1 AA076118 AA975618 AA076220
409695 114876.1 AA296961 AA296889 AA076945 AA077528 AA077497
409745 115237.1 AA077391 AI347618 AI361453AI088754 AW207491 AW960912 AA921874 AA286833AA150722 BE152353AW188822BE152450
409770 1154048 1 AW499536 AW499553 AW502138 AW499537 AW502136 AW501743
410008 116812.1 AA079552 BE142525 BE142527
410049 1172307.1 AW579475 AW939654 AW939655
410534 1207247.1 AW905138 AW753008 R13818 Z43519
410754 1219733.1 T63840 AW801569 AW801568
411290 1237738.1 AW835544 AW835613 AW835711 AW835697 AW835703 BE092535 BE092199411485 1247181.1AW848125 AW848124 AW848203 AW848695
AW848633 AW848693 BE350771
411545 1249138.1 AW850818 AW850833 AW851100 411836 1260619.1 AW901879 AW901875 AW866247 BE011294 BE504813 412209 1283610.1 AW901456 AW901450 AW901441 412359 129085.1 AW837985 AW837938 AA101955 AW837913 AW837935 412379 1292479.1 AW947581 AW947546 AW947545 AW947544 412685 1321663 1 BE092186 BE092157 AW983859 412872 1333898.1 BE006341 BE006307 BE006311 413070 134815.1 AA126776 AA133984 BE148613 BE063475 AA358219 415610 1540554.1 L44319 F12851 T75057 415713 154859.1 AW968573 AA167225 AA491129 416462 1595954.1 W92845 H57479 416548 1600181 1 H62953 N76608 N72413 416913 163001 1 AW934714 BE161007 BE162500 AW749902 AW749864 BE162498 BE161005 AA190449 AW513465 BE161006 BE162499 417038 164390.1 T85230 AA192508 T89190 418053 171810.1 AA211493 AW817839 AW817836 419213 182860.1 AW749146 AW749138 AW749123 AW749130 AA235142 419546 185766.1 AA244199 AA244272 H57440 420637 195241.1 AW976153 AA278945 AA747691 422063 210852.1 BE156476 BE156473 BE156474 BE156475 AA302839 422219 213547.1 AW978073 AW978072 AA807550 AA306567 422504 217160.1 AA311407 AW958321 N23583 R70050 423735 231498.1 AA330259 AA661806 AA502431 AW974633 AA649496 426384 266211.1 AI472078 AA377209 AA865807 427072 274884.1 H38046 W69645 AA397968 H38047 428637 293660.1 AW979268 AA878419 AA431342 AA431628 430183 31412.2 BE010038 AA676833 AI311783 T86895 W68032 BE064393 BE064394 BE157228 BE183282 AI936370 AA552514 T67280 AA039909 431595 335512.1 AA508196 BE142920 AI280311 AI205616 D61709 432009 34025 1 AL137424 BE007148 T52277 437205 43463 1 AL110232 N94765 437938 44573 2 AI950087 N70208 R97040 N36809 AI308119 AW967677 N35320 AI251473 H59397 AW971573 R97278 W01059 AW967671 AA908598 AA251875
AI820501 AI820532 W87891 T85904 U71456 T82391 BE328571 T75102 R34725 AA884922 BE328517 AI219788 AA884444 N92578 F13493 AA927794
AI560251 AW874068 AL134043 AW235363 AA663345 AW008282 AA488964 AA283144 AI890387 AI950344 AI741346 AI689062 AA282915 AW102898
AI872193 AI763273 AW173586 AW150329 AI653832 AI762688 AA988777 AA488892 AI356394 AW103813 AI539642 AA642789 AA856975 AW505512
AI961530 AW629970 BE612881 AW276997AW513601 AW512843 AA044209AW856538 AA180O09 AA337499 AW961101 AA251669 AA251874
AI819225 AW205862 AI683338 AI858509 AW276905 AI633006 AA972584 AA908741 AW072629 AW513996 AA293273 AA969759 N75628 N22388
H84729 H60O52 T92487 AI022058 AA780419 AA551005 W80701 AW613456 AI373032 AI564269 F00531 H83488 W37181 W78802 R66056 AI0O2839
R67840 AA3OO207 AW959581 T63226 F04005
438966 4674361 AW979074 AA834841 AA828650
438993 467651 1 AA828995 AA834879 AI926361
440680 500121 1 AA903098 AW836693 BE160824 AW606818 AW582699 AW836766
442438 5424691 AA995998 AI916584 R61781 T77332 F07756 F08149 F07647
446346 6735451 AI290205 AW235762 AI651268
446417 6763841 AI299050 BE256910
447641 730431 BE619186 BE264952 R26042
448450 76399.1 BE612490 T05205 AA481187
449034 7948171 AI624049 AW117770AI858360
450625 840321 AW970107 AA513951 AA010406
452453 918300.1 AI902519 AI902518 AI902516
453743 979613.1 AL120480 AW836448 AW176802
453955 9898771 AW579207 AW936883 AW008026 N88905
454392 1158821 BE260893 AA078319 R85057 AW803024 H85811 AA078293
454490 12171721 AW797778 AW797781 AW797780
454690 12291061 AW854639 AW854719 AW854718 BE145880 AW854692 BE145866 AW816154 AW854698 AW854654 AW813335 AW854699
454933 12455151 BE141714 AW845993 AW845989
455070 12522091 AW854675 AW854685 AW854716 AW854690 AW854615 AW854624 AW854623 AW854641 AW854632 AW854695 AW854661
455180 12586581 AW863503 AW863362
455275 12722551 AW977806 AW887923 AW886321 455362 1284507 1 AW902635 AW902574 BE011167 BE011329 AW902808 AW902651
455711 1352369 1 BE069465 BE069505
456386 1842693 -1 W28481
456388 1842839 -1 W28557
456411 185688 1 AA603305 AA244095 AA244183
459587 94893 T AA031956
459595 969956 1 AL040421
TABLE 33C
Pkey Unique number conesponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, el al * refers to the publicadon endtled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted
NLpositior i Indicates nudeodde posidons of predicted exons
Pkey Ref Strand Nt_posιdon
401078 3687273 Plus 105052-105171
401157 9438289 Minus 114133-114247,114567-114645
401189 9690246 Minus 90815-90929
401260 8076883 Minus 86008-86355
401352 9931258 Minus 26064-26208
401439 8246737 Plus 92993-94026
401707 2951946 Plus 21972-22104
401811 6730720 Plus 107002-107209
401976 3095020 Minus 17594-17709,21068-21175
402045 7923943 Plus 5964-6128
402421 9796341 Minus 46609-46662,46758-46811 ,86293-86346,89776-89829,90048-90101 ,102817-102924
402696 7328818 Minus 23600-23731
402739 9212192 Plus 60456-61019
402921 7981303 Minus 52242-52384,55599-55858,57124-57309,59633-59761 ,59957-60123
403095 8954339 Plus 150025-150240, 151564-151690
403111 8980970 Plus 175012-175159
403144 9454649 Minus 166200-166628
403170 9838134 Plus 40955-41356
403345 8569726 Plus 77890-78069
403346 8569726 Plus 92752-93015
403563 8101139 Plus 2800-3501
403622 8569879 Plus 1941-2388,2580-2761
403782 8078608 Plus 41326-41633
403797 8099896 Minus 123065-125008
403899 7381715 Minus 9144-9350
404021 8655966 Plus 192534-193489
404115 9621489 Plus 232707-232982
404200 6010176 Minus 7066-7210
404347 9838195 Plus 74493-74829
404939 6862697 Plus 175318-175476
405257 7329310 Plus 73121-73273
405336 6094635 Plus 33267-33563
405394 6624123 Minus 31900-32373
405547 1054740 Plus 124361-124520,124914-125050
405609 5757553 Minus 42814-43010,43583-43783,44863-45033,46429-46554,47815-48018,49961-50153,51624-51727,51823-51959,52702-52918,55469- 55601 ,57111 -57307,58169-58296,60215-60332,61482-61727
405908 6758795 Plus 97969-98715
405943 6758796 Plus 20605-20812
405953 7960374 Minus 65101-65574
405963 8247786 Plus 4056-4699
406007 8247802 Minus 13484-13829
406030 8312328 Minus 96123-96547
406088 9123919 Minus 65772-66270
406117 9142932 Plus 54304-54584
406242 7417725 Minus 36736-36951
406291 5686274 Plus 9562-9867
406411 9256407 Plus 7400-7527
406414 9256407 Plus 49593-49850
406504 7711360 Minus 107068-107277
406506 7711374 Minus 6843-8077
406598 8248614 Plus 56373-56849
TABLE 34A ABOUT 197 GENES UP-REGULATED IN KIDNEY CANCER
Table 34A lists about 197 genes up-regulated in kidney cancer compared to normal adult tissues that are likely to be extrxellular or cell-surfxe proteins These were selected as for
Table 33A and the predicted protein contained a structural domain that is indicative of extrxellular locahzadon (e g ig, fn3, egf, 7tm domans) Predicted protein domains are noted
Pkey Unique Eos probeset identifier number
ExAccn Exemplar Accession number, Genbank xcessioπ number
UnigenelD Unigene number
Unigene Title Unigene gene dtle
PSDomain Protein Structural Domain
R1 Ratio of tumor to normal dssue
Pkey ExAccn UnigenelD UπigeneTitle PSDoman R1
421471 U90545 i Hs 104635 solute earner TM.SS 10074
452401 NM 007115 Hs 29352 tumor necrosis TM,SS,Xlmk,CUB 3364
421727 Y13153 Hs 107318 kynurenme 3-mo TM.SS.Monooxygenase 3236 426471 M22440 Hs 170009 transforming gr TM.SS.EGF 2246
441031 AH 10684 Hs 7645 fibπnogen, B b fibπnogeπ.C 1740
411642 NM_014932 Hs 71132 neuroligm 1 TM.SS.COesterase 1724
452838 U65011 Hs 30743 prefereπdally TM 161 4
425984 AW836277 Hs 165636 hypothedcal pr TM 151 0
453165 S74727 Hs 32042 aspartoxylase TM 1348
452431 U88879 Hs 29499 toll-like recep TM,SS,TIR,LRRCT 1306
423508 AW604297 Hs 129711 hepatitis A vir TM,SS,ιg 1204
407975 X89426 Hs 41716 endothelial cel SS.IGFBP 111 8
415076 NM_000857 Hs 77890 guanylate cycla TM,guanylate_cyc 970
447046 AA326187 Hs 17170 G protein-coupl TM,7tm_1 902
423109 M59305 Hs 123655 natnuredc pep TM,SS,ANF_receptor 780
422544 AB018259 Hs 118140 KIAA0716 gene p TM 748
429352 AK001512 Hs 200097 hypothedcal pr TM 730
453392 U23752 Hs 32964 SRY (sex determ TM,HMG_box 722
403345 TM.alpha-amylase 696
430440 X52599 Hs 2561 nerve growth fa TM,SS,NGF 690
408609 AA330431 Hs 640 calcitonin rece TM,SS,7tm_2 574
449101 AA205847 Hs 23016 G protein-coupl TM,7tm_1 520
423685 BE350494 Hs 49753 Homo sapiens mR TM.Myos tail 480
452891 N75582 Hs 212875 ESTs, Weakly si SS 440
408430 S79876 Hs 44926 dipepddylpepd TM,SS,DPPIV_N_term,Pepddase_S9 426
419287 X91906 Hs 89872 chlonde channe TM.CBS.voltage CLC 406
428822 W28418 Hs 301148 potassium volta TM 402
434208 T92641 Hs 127648 hypothedcal pr TM.SS 392
400792 AA635062 Hs 50094 Homo sapiens mR TM,BIR,CARD,zf-C3HC4 386
444743 AA045648 Hs 11817 nudix (nucleosi TM. utT 384
406411 TM,vwa,FG-GAP 376
423657 AL045128 HS 1691 glucan (1,4-alp TM.alpha-amylase 37 5
424871 NM 004525 Hs 153595 low density lip TM.SS.EGF.WI recept a,ldl_recept_b 328
449625 NM 014253 Hs 23796 odz (odd Oz/ten SH2.EGF 305
423020 AA383092 Hs 1608 replication pro TM 296
422420 U03398 Hs 1524 tumor necrosis TM.TNF 296
414245 BE148072 Hs 75850 WAS protein fam TM WH2 28 8
410247 AF181721 Hs 61345 RU2S TM 274
406414 TM,vwa,FG-GAP 272
435951 AF269162 Hs 41267 c21orf7form A- TM 27 2
419948 AB041035 Hs 93847 NADPH oxidase 4 TM,SS,Femc_reduct 264
448595 AB014544 Hs 21572 KIAA0644 gene p TM,SS,LRRCT,LRR 258
419569 AI971651 Hs 91143 jagged 1 (Alagi TM,SS,DSL,EGF 256
433242 AB040938 Hs 113940 KIAA1505 protei SS 256
416778 M16505 Hs 79876 steroid sulfata TM.Sulfatase 230
401352 TM 226
404200 SS 196
446591 H44186 Hs 15456 PDZ domain cont TM.PDZ 19 2
431806 AF186114 Hs 270737 tumor necrosis TM.SS 180
423909 AJ223183 Hs 135194 immunoglobulin TM.SS ig 176
446364 AB006624 Hs 14912 KIAA0286 protei TM 174
425695 NM .05401 Hs 159238 protein tyrosm TM Band_41,Y_phosphatase 170
410947 AK000305 Hs 67055 hypothedcal pr TM 168
421002 AF116030 Hs 100932 transcnpdon f TM,KRAB,zf-C2H2 16 5
421659 NM 014459 Hs 106511 protocadhenn 1 TM SS cadhenn 160
458679 AW975460 Hs 143563 ESTs SS 144
406598 SS 136
428508 BE252383 Hs 184668 SBBI31 protein TM.PX 132
423321 AB013885 Hs 126926 beta-ureidoprop TM,SS,CN_hydrolase 125
422317 NM 001147 Hs 115181 angiopoiedn 2 fibπnogen C 122
428227 AA321649 Hs 2248 small inducible IL8 120
414923 AW445008 Hs 77637 homeo box A4 TM.homeobox 11 9
433231 AB040926 Hs 143552 KIAA1493 protei SS 11 6
443672 AA323362 Hs 9667 butyrobetane ( TM 11 4
405609 TM,Myosm_taιl myosm.head 11 4
418912 NM 000685 Hs 89472 angioteπsin rec TM,7tm 1 11 4
449802 AW901804 Hs 23984 hypothedcal pr TM 11 2
404347 SS 108
429945 NM 006729 Hs 226483 diaphanous (Dro TM.FH2 106
435085 AW130284 Hs 192752 ESTs, Moderatel TM 106
404115 SS 10 2
420757 X78592 Hs 99915 androgen recept TM,Androgen_recep,hormone_rec,zf-C4 102
446298 AF187813 Hs 14637 kidney- and liv TM,Acetyltransf 10 1
433703 AA210863 Hs 3532 nemo-like kinas TM.pkmase 92
417404 NM 007350 Hs 82101 plxkstπn homo TM 92
451621 AI879148 Hs 26770 fatty xid bind TM SS.Iipocalm 92
402045 TM.SS 90
403095 SS PAX.homeobox 88
401439 TM 86
407721 Y12735 Hs 38018 dual-specificit TM.pk ase 84
402921 TM 84
419503 AA243642 Hs 137422 ESTs TM 84
452259 AA317439 Hs 28707 signal sequence TM 84
402696 TM 83
450001 NM 001044 Hs 406 solute earner TM,SS,SNF 81
433190 M26901 Hs 3210 renin SS.asp 78 449444 AW818436 Hs 23590 solute earner TM.MCT 77
444042 NM.004915 Hs 10237 ATP-bindmg eas TM,ABC_tran 77
452883 X80031 Hs 150318 ESTs TM,C4,Collagen 74
425151 AA351814 Hs 298678 ESTs TM 72
455068 AI807894 Hs 27910 centrosomal pro TM.SS 72
406504 TM 72
410274 AA381807 Hs 61762 hypoxia-inducib SS 70
423349 AF010258 Hs 127428 homeo box A9 TM.homeobox 68
408771 AW732573 Hs 47584 potassium volta TM,K tetra.ion rans 68
445575 Z25368 Hs 172004 ddn TM 66
415138 C18356 Hs 78045 dssue fxtor p Kuπιtz_BPTI,G-gamma 63
443595 AF169312 Hs 9613 PPAR(gamma) ang TM,SS,fibπnogen_C 63
404939 TM 63
436209 AW850417 Hs 254020 ESTs, Moderatel TM.SS 62
403111 TM 62
405394 TM 60
454392 BE260893 gb 601150677F1 TM.SS 60
415910 U20350 Hs 78913 chemokine (C-X3 TM,7tm_1 59
402421 TM 58
425717 X07282 Hs 171495 rednoic xid r TM,hormone_rec,zf-C4 57
427920 Z11502 Hs 181107 annexin A13 TM, annexin 56
407864 AF069291 Hs 40539 chromosome 8 op TM,FHA,BRCT 55
441006 AW605267 Hs 7627 CGI-60 protein TM 54
422232 D43945 Hs 113274 transcπption f TM.HLH 54
425782 U66468 Hs 159525 cell growth reg SS 53
450236 AW162998 Hs 24684 KIAA1376 protei TM.SS 53
413841 M34276 Hs 75576 plasmmogen SS.trypsm.kπngle.PAN 53
436032 AA150797 Hs 109276 latexin protein TM 5 1
447081 Y13896 Hs 17287 potassium inwa TM.IRK 51
421126 M74587 Hs 102122 insulin-like gr SS,thyroglobulιn.1,IGFBP 5 1
426651 AU076646 Hs 171683 nuclear recepto TM,zf-C4,hormone rx 50
432328 AI572739 Hs 195471 6-phosphofructo TM,6PF2K,PGAM 50
409506 NM 006153 Hs 54589 NCK adaptor pro TM.SH2.SH3 50
410361 BE391804 Hs 62661 guanylate bmdi TM.SS.GBP 48
453891 AB037751 Hs 36353 Homo sapiens mR TM 48
447269 NM 004861 Hs 17958 cerebroside (3 TM.SS 48
422357 AF016272 Hs 115418 cadhenn 16, KS TM.cadhenn 48
417355 013168 Hs 82002 endothelin rece TM,SS,7tm_1,zf-C3HC4 47
402739 SS 46
443486 NM 003428 Hs 9450 zinc finger pro TM,KRAB,zf-C2H2 46
408380 AF123050 Hs 44532 diubiquidn TM,ubιquιdn,7tm 3.ANF receptor,sushι,7tm 1 46
414812 X72755 Hs 77367 monokme induce SS.IL8 44
424063 NM 002019 Hs 138671 fins-related tyr TM.SS.pkmase.ig 44
413384 NM 000401 Hs 75334 exostoses (mult TM 44
457030 AI301740 Hs 173381 dihydropyπmidi TM.SS.Dihydroorotase 44
410407 X66839 Hs 63287 carbonic anhydr TM,SS,carb_anhydrase 43
401157 TM.citrate synt 43
432004 BE018302 Hs 2894 plxental growt SS.PDGF 43
424704 AI263293 Hs 152096 cytochrome P450 SS,p450 42
407065 Y10141 gb H sapiens DA TM,SS,SNF 42
411213 AA676939 Hs 69285 neuropilin 1 TM,CUB,F5_F8 type.CMAM 42
430806 S69377 Hs 247978 T-cell xute ly TM.HLH 4 1
414696 AF002020 Hs 76918 Nie ann-Pick di TM.SS.Patched 4 1
408830 AK001709 Hs 48403 hypothetical pr TM.UPF0013 4 1
416655 AW968613 Hs 79428 BCL2/adenovιrus TM 4 1
412494 AL133900 Hs 792 ADP-πbosylado TM,arf,zf-B_box,zf-C3HC4 40
453195 BE241876 Hs 32352 hypothedcal pr TM 40
428816 AA004986 Hs 193852 ATP-bindmg eas TM.ABC membrane.ABC tran,COX15-CtaA 39
401189 TM,SET,PHD,HMG_box 38
451988 AF263928 Hs 27410 papillomavirus TM 38
421013 M62397 Hs 1345 mutated in colo TM 37
420041 AB005142 Hs 94592 klotho TM.SS.GIyco hydro 37
432579 AF043244 Hs 278439 nucleolar prote TM 36
453496 AA442103 Hs 33084 solute caπer TM.SS.sugar.tr 36
446636 AC002563 Hs 15767 citron (rho-int TM.CNH.DAG PE-bιnd,PH,pkιnase.pkιn3se C 36
426274 D38122 Hs 2007 tumor necrosis TM NF 36
452355 N54926 Hs 29202 G protein-coupl TM,7tm 1 35
453775 NM 002916 Hs 35120 replication fx TM,SS,AAA 34
426559 AB001914 Hs 170414 pared basic am TM.Pepddase S8.P 34
420737 L08096 Hs 99899 tumor necrosis TMJNF 34
448733 NM 005629 Hs 187958 solute carrier TM.SNF.ABC tran,ιsodh,pkιnase,Rιbosomal_L18ae 34
413719 BE439580 Hs 75498 small inducible SS.IL8 34
427914 AA417350 Hs 20575 ESTs TM.GAS2 34
412642 BE244598 Hs 809 hepatocyte grow knngle,PAN,trypsιn 34
421893 NM.001078 Hs 109225 vascular cell a TM,SS,ιg 33
417924 AU077231 Hs 82932 cyclin D1 (PRAD TM.cyclin 33
405257 TM 33
450396 AU077002 Hs 24950 regulator of G- TM.RGS 33
416892 L24498 Hs 80409 growth arest a TM.Ribosomal L7Ae 33
425236 AW067800 Hs 155223 stanniocalcin 2 SS 33
430812 L10405 Hs 247992 DNA binding pro TM.SS 32
431842 NM 005764 Hs 271473 epithelial prot TM.SS 32
424897 D63216 Hs 153684 fπzzled-relate TM,Fz,NTR 32 414821 M63835 Hs 77424 Fc fragment of TM.SS ig 3 1
418030 BE207573 Hs 83321 neuromediπ B SS 3 1
421633 AF121860 Hs 106260 sorting nexin 1 TM.PX 31
441285 NM 002374 Hs 167 microtubule-ass SS.tubulm-binding 31
418526 BE019020 Hs 85838 solute earner TM.MCT 3 1
401260 TM.SS 31
450705 U90304 Hs 25351 iroquois-dass TM.homeobox 3 1
424415 NM_001975 Hs 146580 enolase 2, (gam TM,SS,enolase 30
403346 TM.alpha-amylase 30
432757 AF113013 Hs 278919 PRO0806 protein TM 30
434398 AA121098 HS 3838 serum-mducible TM,pkιπase,POLO_box 30
424539 L02911 Hs 150402 xdvin A recep TM,Acdvιn recp pkinase 30
406117 SS 30
408119 W26213 gb 22d10 Human TM.SS 30
431984 AL080239 Hs 272284 Human DNA seque TM 30
403782 TM 30
447922 Z92910 Hs 20019 hemochromatosis TM,SS,ιg,MHC l,hιstone,SPRY,zf-B box,zf-C3HC4 30
428857 AF008192 Hs 194283 putadve GR6 pr SS 30
432596 AJ224741 Hs 278461 matπlin 3 SS 30
453202 AW085781 Hs 26270 Homo sapiens cD TM 30
405547 TM,SS,ABC membrane,ABC tran 30
423496 U91963 Hs 129700 tolloid-like 1 TM,SS,EGF,CUB,Astxιn 30
401707 SS 30
403144 TM.ion.trans.K.tetra 30
418375 NM 003081 Hs 84389 synaptosomal-as TM.NA 30
422992 AF016833 Hs 122785 maltase-glucoam TM.Glyco.hydro 31, trefoil 30
406506 TM 30
413472 BE242870 Hs 75379 solute earner TM.SDF 30
TABLE 34B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT number Accession
408119 1040172.1 W26213 H08055 Z44031 AW954559 R17434
454392 115882.1 BE260893 AA078319 R85057 AW803024 H85811 AA078293
TABLE 34C
Pkey Unique number conesponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham, et al " refers to the publicadon endded "The DNA sequence of human chromosome 22" Dunham et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted
Nt_posιdor i Indicates nucleotide positions of predicted exons
Pkey Ref Strand Nt position
401157 9438289 Minus 114133-114247,114567-114645
401189 9690246 Minus 90815-90929
401260 8076883 Minus 86008-86355
401352 9931258 Minus 26064-26208
401439 8246737 Plus 92993-94026
401707 2951946 Plus 21972-22104
402045 7923943 Plus 5964-6128
402421 9796341 Minus 46609-46662,46758-46811,86293-36346,89776-89829,90048-90101,102817-102924
402696 7328818 Minus 23600-23731
402739 9212192 Plus 60456-61019
402921 7981303 Minus 52242-52384,55599-5585857124-57309,59633-59761 ,59957-60123
403095 8954339 Plus 150025-150240,151564-151690
403111 8980970 Plus 175012-175159
403144 9454649 Minus 166200-166628
403345 8569726 Plus 77890-78069
403346 8569726 Plus 92752-93015
403782 8078608 Plus 41326-41633
404115 9621489 Plus 232707-232982
404200 6010176 Minus 7066-7210
404347 9838195 Plus 74493-74829
404939 6862697 Plus 175318-175476
405257 7329310 Plus 73121-73273
405394 6624123 Minus 31900-32373
405547 1054740 Plus 124361-124520,124914-125050
405609 5757553 Minus 42814-43010,43583-43783,4486345033,46429-46554,47815-48018,49961-50153,51624-51727,51823-51959 52702-5291855469- 55601,57111-57307,58169-5829660215-60332,61482-61727
406117 9142932 Plus 54304-54584
406411 9256407 Plus 7400-7527
406414 9256407 Plus 49593-49850
406504 7711360 Minus 107068-107277
406506 7711374 Minus 6843-8077
406598 8248614 Plus 56373-56849
TABLE 35A ABOUT 532 GENES UP-REGULATED IN KIDNEY CANCER
Table 35A lists about 532 genes up-regulated in kidney cancer compared to normal kidney These were selxted as for Table 33A except using an "average" of the 70th pxendle for both the numerator and the denominator and using non-malignant kidney specimens in determining the denominator value Pkey Unique Eos probeset identifier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dtle
R1 Ratio of tumor to normal dssue
Pkey ExAccn UnigenelD UnigeneTide R1
424704 AI263293 Hs 152096 cytochrome P450, subfamily IIJ (arxhido 409
426559 AB001914 Hs 170414 paired basic ammo xid cleaving system 356
458079 AI796870 Hs 54277 ESTs 346
433447 U29195 Hs 3281 neuronal pentraxin II 320
439979 AW600291 Hs 6823 hypothedcal protein FU 10430 293
446921 AB012113 Hs 16530 small inducible cytokine subfamily A (Cy 259
435359 T60843 Hs 189679 ESTs 254
450152 AI138635 Hs 22968 ESTs 252
452401 NM 007115 Hs 29352 tumor nxrosis fxtor, alpha-induced pro 248
440304 BE159984 Hs 125395 ESTs 245
414821 M63835 Hs 77424 Fc fragment of IgG, high affinity la, re 234
421155 H87879 Hs 102267 lysyl oxidase 224
452795 AW392555 Hs 18878 hypothedcal protein FU21620 222
414812 X72755 Hs 77367 monokine induced by gamma interferon 22 1
426471 M22440 Hs 170009 transforming growth fxtor, alpha 21 3
427897 NMJ17413 Hs 181060 apelm, pepdde ligand for APJ receptor 21 3
449523 NM_0OO579 Hs 54443 chemokine (C-C modf) receptor 5 207
436961 AW375974 Hs 156704 ESTs 205
447499 AW262580 Hs 147674 KIAA1621 protein 204
438817 AI023799 Hs 163242 ESTs 204
430630 AW269920 Hs 2621 cystadn A (stefin A) 198
428227 AA321649 Hs 2248 small inducible cytokine subfamily B (Cy 195
424086 AI351010 Hs 102267 lysyl oxidase 18 7
425289 AW139342 Hs 155530 interferon, gamma-inducible protein 16 187
436476 AA326108 Hs 53631 ESTs, Weakly simila to enhancer-of spli 187
415286 AW249540 Hs 72548 ESTs 182
428157 AI738719 Hs 298668 ESTs 18 1
456804 AI421645 Hs 139851 caveolm 2 178
429490 AI971131 Hs 293684 ESTs, Weakly similar to alternatively sp 175
429732 U20158 Hs 2488 lymph∞yte cytosolic protein 2 (SH2 doma 17 1
433757 AI949974 Hs 152670 ESTs 168
400419 AF084545 Hs 81800 chondroidn sulfate proteoglycan 2 (vers 164
428046 AW812795 Hs 155381 ESTs, Moderately similar to I38022 hypot 163
411642 NM_014932 Hs 71132 neuroligin 1 16 2
444381 BE387335 Hs 283713 ESTs Weakly similar to CA54 HUMAN COLLA 160
435767 H73505 Hs 117874 ESTs 157
427581 NM 014788 Hs 179703 KIAA0129 gene product 156
448019 AW947164 Hs 195641 ESTs 156
406671 AA129547 Hs 285754 met proto-oncogene (hepatocyte growth fa 155
447835 AW591623 Hs 164129 ESTs 154
448520 AB002367 Hs 21355 doublecordn and CaM kinase-like 1 14 8
417308 H60720 Hs 81892 KIAA0101 gene product 148
432731 R31178 Hs 287820 fibronxtin 1 147
421566 NMJ00399 Hs 1395 early growth response 2 (Krox-20 (Drosop 146
419235 AW470411 Hs 288433 neurotnmin 14 6
426490 NM.001621 Hs 170087 aryl hydrocarbon receptor 14 4
421485 AA243499 Hs 104800 hypothetical protein FLJ10134 144
422603 BE242587 Hs 118651 hematopoietically expressed homeobox 14 4
418110 R43523 Hs 217754 Homo sapiens cDNA FU 22202 fis clone H 14 2
425984 AW836277 Hs 165636 hypothetical protein DKFZp761C07121 142
432606 NM_002104 Hs 3066 granzyme K (senne protease, granzyme 3, 14 1
436772 AW975688 Hs 250867 zona pellucida glycoprotein 3A (sperm re 140
444969 AI203334 Hs 160628 ESTs 139
426890 AA393167 Hs 41294 ESTs 138
437330 AL353944 Hs 50115 Homo sapiens mRNA, cDNA DKFZp761 J1112 (f 138
458809 AW972512 Hs 20985 sιn3-assocιated polypepdde, 30kD 137
446627 AI973016 Hs 15725 hypothedcal protein SBBI48 136
452960 AK001335 Hs 31137 Homo sapiens cDNA FU22681 fis, clone H 133
417280 AW173116 Hs 262206 ESTs 13 1
422173 BE385828 Hs 250619 phortoolin-like protein MDS019 130
420552 AK000492 Hs 98806 hypothetical protein 130
425188 AK002052 Hs 155071 hypothedcal protein FU11190 126
427871 AW992405 Hs 59622 ESTs, Weakly simila to unknown [H sapie 126
446152 AI292036 Hs 150028 ESTs 125
426560 AA381661 Hs 119878 ESTs 124
419034 NM_002110 Hs 89555 hemopotedc cell kinase 123
456508 AA502764 Hs 123469 ESTs, Weakly similar to AF208855 1 BM-01 123
452281 T93500 Hs 28792 Homo sapiens cDNA FLJ11041 fis, clone PL 123
442932 AA457211 Hs 8858 bromodoman adjxent to zinc finger doma 123
426075 AW513691 Hs 270149 ESTs 122
434398 AA121098 Hs 3838 serum-inducible kinase 122
450506 NM 004460 Hs 418 fibroblast xdva on protein, alpha 12 1
425782 U66468 Hs 159525 cell growth regulatory with EF-hand doma 120
426108 AA622037 Hs 166468 programmed cell death 5 11 9
416000 R82342 Hs 79856 ESTs 11 8
450236 AW162998 Hs 24684 KIAA1376 protein 11 7 449679 AI823951 Hs 296668 Homo sapiens cDNA FU11846 fis, clone HE 11 6
441350 AB020690 Hs 7782 paraneoplasdc andgen MA2 11 4
442227 AW771958 Hs 175437 ESTs 11 4
414004 AA737033 Hs 7155 ESTs Weakly simila to 2115357A TYKi pr 11 4
447056 N67879 Hs 157695 ESTs 11 3
444863 AW384082 Hs 301323 ESTs 11 3
452838 U65011 Hs 30743 preferentially expressed antigen in mela 11 2
426780 BE242284 Hs 172199 adenylate cyclase 7 11 1
453160 AI263307 Hs 146228 ESTs 11 1
449539 W80363 Hs 58446 ESTs 11 1
415323 BE269352 Hs 949 neutrophil cytosdic fxtor 2 (65kD, chr 11 0
423508 AW604297 Hs 129711 hepadds A virus cellular receptor 1 11 0
408380 AF123050 Hs 44532 diubiquidn 11 0
448410 AK000227 Hs 21126 hypothedcal protein FU20220 11 0
451277 AK001123 Hs 26176 hypothedcal protein FU10261 108
453165 S74727 Hs 32042 aspartoxylase (ammoxylase 2, Caπavan 108
435380 AA679001 Hs 192221 ESTs 107
447183 AI554733 Hs 173182 ESTs 107
438330 AW450572 Hs 257316 ESTs 106
441392 AW451831 Hs 222119 ESTs, Weakly similar to K1CQ HUMAN KERAT 105
418036 Z37976 Hs 83337 latent transforming growth fxtor beta b 105
452862 AW378065 Hs 8687 ESTs 104
431512 BE270734 Hs 2795 lactate dehydrogenase A 103
421478 AI683243 Hs 97258 ESTs 103
413879 AA132961 Hs 212533 Homo sapiens cDNA FU22572 fis, ctone H 103
411800 N39342 Hs 5184 TH1 drosophila homolog 103
433862 D86960 Hs 3610 KIAA0205 gene product 103
440594 AW445167 Hs 126036 ESTs 102
414504 AW069181 Hs 293523 ESTs, Weakly similar to traπsformadon-r 102
431211 M86849 Hs 5566 gap juncdon protein, beta 2, 26kD (conn 10 2
437682 AA476652 Hs 94952 Homo sapiens cDNA FU23371 fis, clone H 101
430097 AI523245 Hs 127638 ESTs 10 1
432579 AF043244 Hs 278439 nucleolar protein 3 (apoptosis repressor 100
434927 H46612 Hs 293815 Homo sapiens HSPC285 mRNA partial eds 99
424113 AI743880 Hs 12876 ESTs 99
439981 AI348408 Hs 124675 ESTs, Weakly simila to unnamed protein 99
411937 AW876626 gb RC3-PT0028-120200-013-d08 PT0028 Homo 99
439653 AW021103 Hs 6631 hypothedcal protein FU20373 99
428862 NM 000346 Hs2316 SRY (sex-determ mg region Y)-box 9 (ca 98
424623 AW963062 Hs 165809 ESTs 98
410762 AF226053 Hs 66170 HSKM-B protein 98
433285 AW975944 Hs 237396 ESTs 97
413795 AL040178 Hs 142003 ESTs 96
434392 AW983709 Hs 268051 ESTs 96
435542 AA687376 Hs 269533 ESTs 96
430887 N66801 Hs 260287 ESTs Weakly similar to ALU7 HUMAN ALU S 95
410339 AI916499 Hs 298258 ESTs 95
452431 U88879 Hs 29499 toll like receptor 3 95
405121 AB028989 Hs 88500 mitogen-xtivated protein kinase 8 inter 95
408134 AK000184 Hs 42945 xid sphingomyelinase-like phosphodieste 94
438966 AW979074 gb EST391184 MAGE resequences, MAGP Homo 94
449625 NM 014253 Hs 23796 odz (odd Oz/ten-m, Drosophila) homolog 1 94
441024 AW081530 Hs 137088 ESTs 93
445900 AF070526 Hs 13429 Homo sapiens clone 24787 mRNA sequence 92
433001 AF217513 Hs 279905 clone HQ0310 PRO0310p1 92
440074 AA863045 Hs 199057 ESTs Weakly similar to T00050 hypothed 92
421659 NM 014459 Hs 106511 protocadhenn 17 92
434542 AA769310 Hs 61260 hypothedcal protein FU13164 9 1
427283 AL119796 Hs 174185 ectonucleodde pyrophosphatase/phosphodi 91
428820 AA436187 Hs 172631 integnn, alpha M (complement component 9 1
419441 AW023731 Hs 274368 Homo sapiens mRNA cDNA DKFZp586l1524 (f 90
407856 AA045281 Hs 266175 phosphoprotein associated with GEMs 90
431941 AK000106 Hs 272227 Homo sapiens cDNA FU20099 fis, clone CO 90
446460 AW013999 Hs 150164 ESTs 89
452598 AI831594 Hs 68647 ESTs, Weakly simila to ALU7_HUMAN ALU S 89
407975 X89426 Hs 41716 endothelial cell-specific molecule 1 (NO 89
437259 AI377755 Hs 120695 ESTs 87
420235 AA256756 Hs 31178 ESTs 87
436959 AL133076 Hs5354 hypothedcal protein FU12716 87
413554 AA319146 Hs 75426 sxretogranin II (chromogranin C) 86
435894 AI076667 Hs 188011 ESTs 86
418693 AI750878 Hs 87409 thrombospondm 1 86
425770 NM 014363 i Hs 159492 spastic ataxia of Charlevoix-Saguenay (s 86
456249 AI206144 Hs 82508 HRIHFB2206 protein 86
437672 AW748265 Hs 5741 flavohemoprotein b5*b5R 86
430268 AK000737 Hs 237480 hypothedcal protein FU 20730 85
417225 AA815048 Hs 24078 Homo sapiens cDNA FU 12649 fis, clone NT 85
435266 AK001942 Hs 4863 Homo sapiens cDNA FU11080 fis, clone PL 84
447974 R76886 gb yι64b03 s1 Soaes plxenta Nb2HP Homo 84
447850 AB018298 Hs 19822 SEC24 (S cerevisiae) related gene famil 84
429525 N92540 Hs 205353 ectonucleoside tophosphate diphosphohyd 83
435717 AF227905 Hs 105794 UDP-glucose glycoprotein glucosyltransfe 83
445784 AI253155 Hs 146065 . ESTs 83 454024 AA993527 Hs 16281 hypothetical protein FU23403 83
443885 H91806 Hs 15284 ESTs 83
403713 83
433376 AI249361 Hs 74122 caspase 4, apoptosis-related cysteine pr 82
419490 NM.006144 Hs 90708 granzyme A (granzyme 1, cytotoxic T-lymp 82
444670 H58373 Hs 37494 ESTs 82
408761 AA057264 Hs 238936 ESTs 82
453033 AA325869 Hs 31463 KIAA0281 gene product 82
441224 AU076964 Hs 7753 calumemn 8 1
441689 AH 23705 Hs 106932 ESTs 81
440283 AI732892 Hs 190489 ESTs 8 1
429598 AA811257 Hs 269710 ESTs 81
424775 AB014540 Hs 153026 SWAP-70 protein 81
451292 AB037716 Hs 26204 KIAA1295 protein 80
453951 AI676235 Hs 24789 ESTs 80
416200 AI188972 Hs 44257 Homo sapiens mRNA, cDNA DKFZp76202215 (f 80
431087 H12723 Hs 290791 ESTs 80
432328 AI572739 Hs 195471 6-phosphofnιdo-2-kιnase/fructose-2,6-bι 79
419474 AW968619 Hs 155849 ESTs 79
418342 BE002723 Hs 293504 ESTs, Moderately similar to ALU1.HUMAN A 79
408088 AW157022 Hs 4947 Homo sapiens cDNA FU22584 fis, ctone H 79
413719 BE439580 Hs 75498 small inducible cytokine subfamily A (Cy 79
440987 AA911705 Hs 130229 ESTs 79
412448 L12964 Hs 73895 tumor necrosis fxtor receptor superfami 79
415737 AA167626 Hs 118743 ESTs 79
412959 087458 Hs 75090 KIAA0282 protein 78
424247 X14008 Hs 234734 lysozyme (renal amyloidosis) 78
453331 AI240665 Hs 8895 ESTs 78
421991 NM 014918 Hs 110488 KIAA0990 protein 78
443450 N66045 Hs 133529 ESTs 78
431876 AA521183 Hs 269678 ESTs 78
432582 AI623817 Hs 168457 ESTs 77
445800 AA126419 Hs 301632 ESTs 77
424636 AA453734 Hs 10198 ESTs 77
432134 AI816782 Hs 122583 Homo sapiens cDNA FU21934 fis, clone H 77
446873 AI554439 Hs 30724 ESTs 77
400793 AA635062 Hs 50094 Homo sapiens mRNA, cONA DKFZp434O0515 (f 77
436061 AI248584 Hs 190745 Homo sapiens cDNA FU21326 fis, clone C 77
442028 AI239437 Hs 48945 ESTs 77
442760 BE075297 Hs 10067 ESTs, Weakly similar to KIAA1205 protein 77
442152 R39246 Hs 239666 Homo sapiens cDNA FLJ13495 fis, clone PL 77
427944 AA417878 Hs 48401 ESTs, Weakly similar to ALU8.HUMAN ALU S 76
414646 AA353776 Hs 901 CD48 antigen (B-cell membrane protein) 76
407634 AW016569 Hs 301280 ESTs, Highly similar toΛF24183! 1 intra 76
418372 AA311833 Hs 84318 replicadon protein A1 (70kO) 76
434666 AF151103 Hs 112259 T cell receptor gamma locus 76
442432 8E093589 Hs 38178 Homo sapiens cDNA FU23468 fis clone H 76
408418 AW963897 Hs 44743 KIAA1435 protein 76
418805 AI829520 Hs 227513 ESTs 75
425354 U62027 Hs 155935 complement component 3a receptor 1 75
408743 AU 10246 Hs 47367 hypothedcal protein from EUROIMAGE 7836 75
444836 AI589825 Hs 173504 ESTs, Weakly similar to JC5238 galxtosy 75
421810 AK001718 Hs 108530 hypothedcal protein FU 10856 74
432753 NM 014075 Hs 278915 PRO0593 protein 74
420061 AW024937 Hs 29410 ESTs 74
432865 AI753709 Hs 152484 ESTs 74
419070 AW979068 Hs 182503 ESTs 74
430172 AA468591 Hs 161889 ESTs 74
446343 AW771414 Hs 8314 ESTs 74
424125 M31669 Hs 1735 inhibin, beta B (xhvin AB beta polypep 74
453818 BE256832 Hs 10711 Homo sapiens cDNA FU13449 fis, clone PL 74
447046 AA326187 Hs 17170 G protein-coupled rxeptor 4 74
410577 X91911 Hs 64639 glioma pathogenesis-related protein 74
452240 AI591147 Hs 61232 ESTs 73
450375 AA009647 Hs 8850 a dismtegnn and metalloproteinase doma 73
422631 BE218919 Hs 118793 hypothetical protem FU 10688 73
450205 AI219748 Hs 11356 ESTs 73
437212 AI765021 Hs 210775 ESTs 73
440193 AW902312 Hs 7037 pallid (mouse) homolog pallidin 72
417022 NM 014737 Hs 80905 Ras association (RalGDS/AF-6) domain fam 72
451818 AI819018 gb ts54f01 x1 NCI.CGAP.Kid8 Homo sapiens 72
453013 AA031407 gb zk15g12 r1 Soares _pregnant_uterus_NbH 72
430105 X70297 Hs 2540 cholinergic receptor, nicodnic, alpha p 72
451621 AI879148 Hs 26770 fatty xid binding protein 7, brain 72
442438 AA995998 gb os26b03 s1 NCI_CGAP_Kιd5 Homo sapiens 72
415138 C18356 Hs 78045 tissue fxtor pathway inhibitor 2 72
407305 AA715284 gb nv35f03 r1 NCI_CGAP_Br5 Homo sapiens 72
452814 A1092790 Hs 55016 hypothedcal protein FLJ21935 72
426028 NM 001110 Hs 172028 a dismtegnn and metalloproteinase doma 72
443462 AI064690 Hs 171176 ESTs 72
422060 R20893 Hs 75613 CD36 antigen (collagen type 1 receptor, 72
434096 AW662958 Hs 75825 pleiomorphic adenoma gene-like 1 7 1
443161 AI038316 gb ox48c08 x1 Soares otaLfetus Nb2HF8 7 1 458725 AW970192 Hs 171942 ras responsive element binding protein 1 7 1
426423 NM 012446 Hs 169833 single-stranded-DNA-binding protein 7 1
412783 BE276738 Hs 74578 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 71
435664 AI032087 Hs 269819 ESTs 70
431708 AI698136 Hs 108873 ESTs 70
426501 AW043782 Hs 293616 ESTs 70
453548 AL079983 Hs 75442 albumin 70
426595 AW971980 Hs 62402 p21/Cdc42/Rx1-xdvated kinase 1 (yeast 70
412490 AW803564 Hs 288850 Homo sapiens cDNA FU22528 fis, clone H 70
431556 AF016028 Hs 260039 sarcospan (Kras oncogene-associated gene 69
420018 U56387 Hs 94376 proprotein convertase subdlisiπ/kexin t 69
418986 AI123555 Hs 81796 ESTs 69
430290 AI734110 Hs 136355 ESTs 69
427472 AA522539 Hs 131250 transposon-deπved Buster3 transposase-l 69
444042 NM 004915 Hs 10237 ATP-bmding cassette, sub-family G (WHIT 69
414737 Al 160386 Hs 125087 ESTs 69
420479 AW183695 Hs 186572 ESTs 69
432656 NM 000246 Hs 3076 MHC class II transxdvator 69
414217 AI309298 Hs 279898 Homo sapiens cDNA FU23165 fis, clone L 69
431870 AW449902 Hs 105500 ESTs 69
415788 AW628686 Hs 78851 KIAA0217 protein 69
430066 AI929659 Hs 237825 signal recognition particle 72k0 69
437156 AI916600 Hs 121194 Homo sapiens cDNA FU21569 fis, clone C 68
401539 68
412782 AI189211 Hs 173044 ESTs 68
416058 L08895 Hs 78995 MADS box transcπption enhancer fxtor 2 68
437205 AL110232 gb Homo sapiens mRNA, cDNA DKFZp564D2071 67
458814 AI498957 Hs 170861 ESTs 67
452106 AI141031 Hs 21342 ESTs 67
413249 AF167160 Hs 75251 DEAD/H (Asp-Glu Ala-Asp/His) box binding 67
420910 AL049437 Hs 100292 Homo sapiens mRNA, cDNA DKFZp586E1120 (f 67
445527 W39694 Hs 83286 ESTs 67
424063 NM 002019 Hs 138671 fms-related tyrosine kinase 1 (vascular 67
421977 W94197 Hs 110165 nbosomal protein L26 homolog 67
430280 AA361258 Hs 237868 interieukin 7 rxeptor 67
415989 AI267700 Hs 111128 ESTs 67
418026 BE379727 Hs 83213 fatty xid binding protein 4, adipocyte 66
425295 AA431366 Hs 37251 ESTs 66
438619 AB032773 Hs 6341 TU12B1-TY protein 66
424916 AW867440 Hs 23096 ESTs 66
429697 AW296451 Hs 24605 ESTs 66
408741 M73720 Hs 646 carboxypepddase A3 (mast cell) 66
403549 66
449008 AW578003 Hs 22826 tropomodul 3 (ubiquitous) 66
435798 BE395289 Hs 12720 elF4E-trans porter 66
447217 BE465754 Hs 17778 neuropilin 2 66
453070 AK001465 Hs 31575 SEC63, endoplasmic reticulum translocon 66
410276 AI554545 Hs 68301 ESTs 66
435391 AA704588 Hs 58934 ESTs 66
421878 AA299652 Hs 111496 Homo sapiens cDNA FLJ 11643 fis, clone HE 66
452092 BE245374 Hs 27842 hypothetical protem FU11210 65
448789 BE539108 Hs 22051 Homo sapiens mRNA, cDNA DKFZp4340119 (fr 65
425331 AW962128 gb EST374201 MAGE resequences, MAGG Homo 65
431956 AK0O2O32 Hs 272245 Homo sapiens cDNA FLJ11170 fis clone PL 65
444880 AW118683 Hs 154150 ESTs 65
434131 AI858275 Hs 143659 ESTs 65
446658 AI440137 Hs 164989 ESTs 65
408150 BE620274 Hs 43112 Homo sapiens mRNA, cDNA DKFZp434B1620 (f 65
403790 65
417129 AI381800 Hs 143275 Homo sapiens cDNA FU 13233 fis. clone OV 65
452119 AI656378 Hs 33461 ESTs 64
437396 BE140396 Hs 21621 hypothetical protein DKFZp762O076 64
458946 AA009716 Hs 42311 ESTs 64
452110 T47667 Hs 28005 Homo sapiens mRNA, cDNA DKFZp564G2463 (f 64
449318 AW236021 Hs 108788 ESTs, Weakly similar to zeste (D melanog 64
408308 AL033377 Hs 44197 hypothetical protein DKFZp564D0462 64
402474 64
430712 AW044647 Hs 196284 ESTs 64
418299 AA279530 Hs 83968 integnn, beta 2 (andgen CD18 (p95), ly 64
432683 AW995441 Hs 10475 ESTs 64
423764 AF054589 Hs 132739 ESTs 64
409571 AA504249 Hs 187585 ESTs 64
401600 BE247275 Hs 151787 U5 snRNP-spxific protein, 116 kD 64
415076 NM 000857 Hs 77890 guanylate cyclase 1 , soluble beta 3 64
432925 AA878324 Hs 192734 ESTs 64
427528 AU077143 Hs 179565 minichromosome mantenance deficient (S 64
453894 AW937825 Hs 56847 Homo sapiens cDNA FU12874 fis, clone NT 64
430335 D80007 Hs 239499 KIAA0185 protem 63
453370 AI470523 Hs 182356 ESTs. Moderately similar to translation 63
421327 AA837295 Hs 188802 ESTs 63
450654 AJ245587 Hs 25275 Kruppel-type zinc finger protein 63
413497 BE177661 gb RC1-HT0598-020300-011-h02 HT0598 Homo 63
445279 R41900 Hs 22245 ESTs 63 429747 M87507 Hs 2490 caspase 1 , apoptosis-related cysteine pr 63
421252 AA765930 Hs 130878 ESTs 63
432140 AK000404 Hs 272688 hypothedcal protein FU 20397 63
434203 BE262677 Hs 283558 hypothetical protein PR01855 62
419436 AA991639 Hs 15036 ESTs Highly similar to AF161358 1 HSPC0 62
430287 AW182459 Hs 125759 ESTs, Weakly similar to tumor suppressor 62
409690 W45393 Hs 94642 ESTs, Highly similar to ATFa [H sapiens] 62
420101 AW500529 Hs 95180 Homo sapiens mRNA, cDNA DKFZp434A205 (fr 6 1
435889 AI249107 Hs 269901 ESTs 6 1
417259 AW903838 Hs 81800 chondroidn sulfate proteoglycan 2 (vers 61
448030 N30714 Hs 20161 HDCME31P protein 6 1
442571 C06338 Hs 165464 ESTs 61
421202 AF193339 Hs 102506 eukaiyodc translation initiation fxtor 6 1
415558 AA885143 Hs 125719 ESTs 61
408042 AL049233 Hs 42244 Homo sapiens mRNA, cDNA DKFZp564A023 (fr 61
438086 AA336519 Hs 301167 Homo sapiens cDNA FU21545 fis, done C 6 1
427390 AI432163 Hs 268231 Homo sapiens cDNA FU23111 fis, clone L 60
440749 W22335 Hs 7392 Homo sapiens mRNA cDNA DKFZp761E0323 (f 60
448822 BE149845 Hs 289038 Homo sapiens cDNA FU20994 fis, clone C 60
424806 AA382523 Hs 105689 ESTs 60
435185 AA669490 Hs 289109 dimethylarginine dimethylaminohydrolase 60
452235 AL039743 Hs 28514 Homo sapiens mRNA, cDNA DKFZp434H092 (fr 60
432415 T16971 Hs 289014 ESTs 60
436345 AA873008 Hs 121572 ESTs 60
439451 AF086270 Hs 278554 heterochromadπ-like protein 1 60
434674 AA831879 Hs 136985 ESTs 60
429653 NM 005955 Hs 211581 metal-regulatory transcπption fxtor 1 60
446822 AB037794 Hs 16229 KIAA1373 protein 60
423590 AW952412 Hs 65874 ESTs 60
424026 AI798295 Hs 123218 ESTs 59
423246 AL119114 Hs 23107 ESTs 59
420982 AW576160 Hs 100729 KIAA0692 protein 59
435008 AF150262 Hs 162898 ESTs 59
420092 AA814043 Hs 88045 ESTs 59
444484 AK002126 Hs 11260 hypothedcal protein FU11264 59
410193 AJ132592 Hs 59757 zinc finger protein 281 59
450534 AI570189 Hs 25132 KIAA0470 gene product 59
440146 AW01 231 Hs 90790 Homo sapiens cDN A FU 22930 fis, clone K 59
425361 AA355933 Hs 132221 Homo sapiens CDNA FU12401 fis, clone MA 59
425174 D87450 Hs 154978 KIAA0261 protein 59
458287 AA987556 Hs 12867 ESTs 59
433793 AW975959 Hs 107513 ESTs, Moderately simila to KIAA1058 pro 58
443228 W24781 Hs 293798 ESTs 58
419983 W55956 Hs 94030 Homo sapiens mRNA, cDNA DKFZp586E1624 (f 58
410361 BE391804 Hs 62661 guanylate binding protein 1, mterferon- 58
415714 NM 002290 Hs 78672 laminm, alpha 4 58
421689 N87820 Hs 106826 hypothetical protein 58
431176 AI026984 Hs 293662 ESTs 58
443837 AI984625 Hs 9884 spindle pole body protein 58
410623 AW958932 Hs 293833 ESTs 58
421298 AW172431 Hs 13012 ESTs 58
449052 AW029507 Hs 161102 ESTs 58
433043 W57554 Hs 125019 ESTs, Highly similar to KIAA0886 protein 58
439444 AI277652 Hs 54578 ESTs 57
428698 AA852773 Hs 297939 ESTs, Weakly similar to T17344 hypothed 57
411928 AA888624 Hs 19121 adaptor-related protein complex 2, alpha 57
442242 AV647908 Hs 90424 Homo sapiens cDNA FU23285 fis, clone H 57
417315 AI080042 Hs 180450 nbosomal protein S24 57
422544 AB018259 Hs 118140 KIAA0716 gene product 57
412584 X54870 Hs 74085 DNA segment on chromosome 12 (unique) 24 57
433505 AW504027 Hs 15301 Homo sapiens NY-REN-25 antigen mRNA, par 57
410425 BE278367 Hs 63510 KIAA0141 gene product 57
457292 AI921270 Hs 214178 Homo sapiens cDNA FU14251 fis, clone OV 57
457100 AA417878 Hs 48401 ESTs, Weakly similar to ALU8 HUMAN ALU S 57
436995 AI160015 Hs 118112 ESTs 57
426283 NM 003937 Hs 169139 kynuremnase (L-kynurenine hydrolase) 57
441518 AW161697 Hs 294150 ESTs 57
448807 AI571940 Hs 7549 ESTs 57
449656 AA002008 Hs 188633 ESTs 57
439211 AI890347 Hs 271923 Homo sapiens cDNA FU22785 (is, clone K 57
430440 X52599 Hs 2561 nerve growth fxtor, beta polypepdde 57
413551 BE242639 Hs 75425 ubiquitin associated protein 57
441633 AW958544 Hs 112242 ESTs 57
427093 AA398118 Hs 97579 ESTs 56
418250 U29926 Hs 83918 adenosine moπophosphate deaminase (isofo 56
432267 AK000872 Hs 274227 Homo sapiens cDNA FU10010 fis, clone HE 56
419839 U24577 Hs 93304 phospholipase A2, group VII (platelet-x 56
430253 AK001514 Hs 236844 hypothedcal protein FU 10652 56
450447 AF212223 Hs 25010 hypothetical protein P15-2 56
434623 AB023163 Hs 4014 KIAA0946 protein, Hundngdn interxdng 56
420642 AK001520 Hs 99545 Homo sapiens cDNA FU 10658 fis, clone NT 56
414020 NM 002984 Hs 75703 small inducible cytokine A4 (homologous 56
420825 AI656727 gb tt53f12 x1 NCI.CGAP.GC6 Homo sapiens 56 422363 T55979 Hs 115474 replication fxtor C (xdvator 1) 3 (38 56
452046 AB018345 Hs 27657 KIAA0802 protein 56
408911 AW294772 Hs 98321 Homo sapiens cDNA FLJ14103 fis, clone MA 56
414844 AA296874 Hs 77494 deoxyguanosine kinase 56
416498 U33632 Hs 79351 potassium channel, subfamily K, member 1 56
430512 AF182294 Hs 241578 U6 snRNA-assoαated Sm-like protein LSm8 56
430339 W28608 Hs 239625 integral membrane protein 2B 56
420153 N22120 Hs 75277 hypothedcal protein FU13910 56
420892 AW975076 Hs 172589 nuclear phosphoprotein similar to S cer 56
441568 AI733322 Hs 127176 ESTs 55
414575 H11257 Hs 295233 ESTs 55
419929 U90268 Hs 93810 cerebral cavernous malformations 1 55
438613 C05569 Hs 243122 hypothedcal protein FU 13057 similar to 55
453064 R40334 Hs 301395 Homo sapiens cDNA FU21204 fis, clone C 55
433409 AI278802 Hs 25661 ESTs 55
407094 AF000574 Hs 22405 leukocyte immunoglobulin-like receptor, 55
425234 AW152225 Hs 165909 ESTs 55
447644 AW861622 Hs 108646 Homo sapiens cDNA FLJ 12534 fis, clone NT 55
411653 AF070578 Hs 71168 Homo sapiens clone 24674 mRNA sequence 55
446534 AI307356 Hs 175225 ESTs 55
452355 N54926 Hs 29202 G protein-coupled receptor 34 55
434715 BE005346 Hs 116410 ESTs 55
440486 BE243513 Hs 7212 hypothedcal protein PP1044 55
444825 AW167613 Hs 248 mitogen-xdvated protein kinase kinase 55
419172 AW338625 Hs 22120 ESTs 54
444931 AV652066 Hs 75113 general transcnpdon fxtor IIIA 54
413940 AI633205 Hs 159914 ESTs 54
410480 R97457 Hs 63984 cadheπn 13, H-cadhenn (heart) 54
447072 D61594 Hs 17279 tyrosylprotem sulfotransferase 1 54
434361 AF129755 Hs 117772 ESTs 54
453392 U23752 Hs 32964 SRY (sex determining region Y) box 11 54
445175 AV652851 Hs 300846 ESTs 54
411213 AA676939 Hs 69285 neuropilin 1 54
412530 AA766268 Hs 266273 Homo sapiens cDNA FLJ13346 fis, clone OV 54
422667 H25642 Hs 133471 ESTs 54
434064 AL049045 Hs 180758 hypothedcal protein PRO0082 54
429688 BE245169 Hs 211610 CUG tπplet repeat RNA-bmding protein 54
452060 W26980 Hs 153612 ATP-bindmg cassette, sub-family F (GCN2 54
419093 AI804054 Hs 112885 ESTs 54
436267 AW450938 Hs 180115 ESTs 54
405257 54
431154 AW971228 Hs 290259 ESTs 54
415511 AI732617 Hs 182362 ESTs 54
419175 AW270037 Hs 179507 KIAA0779 protein 53
454117 BE410100 Hs 40368 adaptor-related protein complex 1 , sigma 53
423720 AL044191 Hs 23388 Homo sapiens cDNA FLJ21310 fis, clone C 53
409995 AW960597 Hs 30164 ESTs 53
414911 NM 000107 Hs 77602 damage-specific DNA binding protein 2 (4 53
455716 BE070263 gb QV4-BT0407-280100-090-e0? BT0407 Homo 53
430598 AK001764 Hs 247112 hypothedcal protein FU10902 53
419985 H66373 Hs 15973 ESTs. Highly similar to bA393J16 3 [H sa 53
428753 AW939252 Hs 192927 hypothetical protein FLJ20251 53
423099 NM.002837 Hs 123641 protein tyrosine phosphatase, receptor t 53
404176 53
431475 AI567669 Hs 287316 ESTs 53
406625 Y13647 Hs 119597 stearoyl-CoA desaturase (delta-9-desatur 53
405475 53
430180 AA331406 Hs 75456 A kinase (PRKA) anchor protein 10 53
446183 AA354991 Hs 14222 Homo sapiens mRNA, cDNA DKFZp761P019 (fr 53
417381 AF164142 Hs 82042 solute earner family 23 (nucleobase tra 53
433029 NM.014322 Hs 279926 opsin 3 (eπcephalopsin) 53
442837 AI022082 Hs 50492 ESTs 53
437140 AA312799 Hs 283689 xdvator of CREM in tesds 53
408989 AW361666 Hs 49500 KIAA0746 protein 53
417355 D13168 Hs 82002 endothelin receptor type B 53
407361 AA744622 Hs 292645 ESTs, Weakly similar to ALU5JHUMAN ALU S 53
437734 AA693951 Hs 180284 ESTs 53
452234 AW084176 Hs 223296 ESTs 53
423057 AW961597 Hs 130816 ESTs 53
439593 BE073597 Hs 124863 ESTs 53
446501 AI302616 Hs 150819 ESTs 53
416406 D86961 Hs 79299 lipoma HMGIC fusion partner-like 2 52
427164 AB037721 Hs 173871 KIAA1300 protein 52
416815 U41514 Hs 80120 UDP-N-acetyl-alpha-D-galxtosamme polyp 52
448212 AI475858 gb tc87d07 x1 NCI.CGAP.CLL1 Homo sapiens 52
412420 AL035668 Hs 73853 bone morphogenedc protem 2 52
416975 NM.0O4131 Hs 1051 granzyme B (granzyme 2 cytotoxic T-lymp 52
406815 AA833930 Hs 288036 tRNA isopentenylpyroptiosphate transferas 52
451418 BE387790 Hs 26369 hypothedcal protein FU20287 52
425322 U63630 Hs 155637 protein kmase, DNA-xdvated, catalytic 52
451156 AI983569 Hs 232042 ESTs 52
415910 U20350 Hs 78913 chemokine (C-X3-C) receptor 1 52
423024 AA593731 Hs 75613 CD36 andgen (collagen type I receptor, 52 428593 AW207440 Hs 185973 degenerative spermatocyte (homolog Droso 52
451149 AL047586 Hs 10283 ESTs 52
429458 BE161832 Hs 292689 ESTs 52
422241 Y00062 Hs 170121 protein tyrosine phosphatase, receptor t 52
432383 AK000144 Hs 274449 Homo sapiens cDNA FU20137 fis clone CO 52
417696 BE241624 Hs 82401 CD69 antigen (p60, earty T-cell xdvad 52
442991 BE281238 Hs 8886 hypothedcal protein FU20424 52
426711 AA383471 Hs 180669 conserved gene amplified in osteosarcoma 52
438995 AI277986 Hs 164875 ESTs 51
438582 AI521310 Hs 283365 ESTs, Weakly simila to ALU5.HUMAN ALU S 51
424859 U92014 Hs 153527 Homo sapiens pTM5 manner-like transpose 51
445563 AW873606 Hs 149006 ESTs 51
416852 AF283776 Hs 80285 Homo sapiens mRNA, cDNA DKFZp586C1723 (f 51
420567 AK000812 Hs 98874 similar to proline-nch protein 48 51
420630 AL133101 Hs 99508 Homo sapiens mRNA cDNA DKFZp434O0921 (f 51
455510 AA422029 Hs 143640 ESTs, Weakly similar to hyperpolaπzatio 51
412676 NM 000165 Hs 74471 gap juncdon protein, alpha 1, 43kD (con 51
438146 Z36842 Hs 57548 ESTs 51
423430 AF112481 Hs 128501 RAD54, S cerevisiae, homolog of, B 51
421633 AF121860 Hs 106260 sorting nexin 10 51
447197 R36075 gb yh88b01 s1 Soares placenta Nb2HP Homo 51
436943 AA773838 Hs 5353 caspase 10, apoptosis-related cysteine p 51
456210 N49729 Hs 156875 ESTs 51
411893 R82845 Hs 273789 ESTs 51
432331 W37862 Hs 274368 Homo sapiens mRNA, cDNA DKFZp586l1524 (f 51
414696 AFO02O20 Hs 76918 Niemann-Pick disease, type C1 51
426822 W78950 Hs 220823 ESTs 51
444269 AI590346 Hs 146220 ESTs 51
437204 AL110216 Hs 12285 ESTs 51
443180 R15875 Hs 70945 ESTs 51
431510 AA580082 Hs 112264 ESTs 50
446312 BE087853 gb QV1-BT0681-290400-181-h05 BT0681 Homo 50
449870 AI672487 Hs 15423 hypothetical protein HDCMC04P 50
430462 AI584156 Hs 105640 ESTs 50
457452 AW972675 gb EST384766 MAGE resequences, MAGL Homo 50
420397 NM 007018 Hs 97437 centrosomal protein 1 50
408750 BE294069 Hs 93581 hypothetical protein FU10512 50
426874 N67325 Hs 247132 ESTs 50
419746 AW867943 Hs 127216 Homo sapiens cDNA FU 13465 fis clone PL 50
434237 AF119908 Hs 235516 hypothetical protein PR02955 50
410274 AA381807 Hs 61762 hypoxia-mducible protein 2 50
T TAABBLLEE 3355BB
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT number Accession 411937 1266219 AW876626 AW876622 AW876624 413497 1373771 1 BE177661 H06215 BE144709 BE144829 420825 196769 T AI656727 AI697887 AI802122 AA910877 Z28718 T16711 AA651731 AL047264 BE000621 R68736 AW992695 AI768764 AW271284 AW974653
AI308951 AW055146 R93609 AW467031 AI096866 AI371871 AI126182 AI564756 AI361460 AI358914 AI419231 AW439733 R87059 AA628064
AW088970 AW008695 R68682 AI719136 R97752 AW196262
425331 250199.1 AW962128 AA355353 AA427363 437205 43463.1 AL110232 N94765 438966 467436.1 AW979074AA834841 AA828650 442438 542469.1 AA995998 AI916584 R61781 T77332 F07756 F08149 F07647 443161 561305.1 AI038316AI344631 AI261653 446312 671114.1 BE087853 AI286184 447197 711623 1 R36075 AI366546 R36167 447974 745643.1 R76886 AI453674 R77049 448212 755099.1 AI475858 AW969013 451818 887271 1 AI819018 R05492W27615 453013 94390.Ϊ AA031407 N85751 AW974119 AA031408AA572965 455716 1352695J BE070263 BE070195 BE070265 BE070202 BE070233 BE070399 BE0702O3 457452 339381.1 AW972675 AA541366 AA523039 407305 312657 AA715284
TABLE 35C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham, et al * refers to the publicadon endtled 'The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495 Strand Indicates DNA strand from which exons were predicted
NLposition Indicates nudeodde positions of predicted exons
Pkey Ref Strand NLposition
401539 8072433 Minus 62028-62608
402474 7547175 Minus 53526-53628,55755-55920,57530-57757
403549 8081591 Minus 137150-137362
403713 6573831 Minus 152769-153155
403790 8084957 Minus 87826-87947,89835-90002
404176 9931122 Plus 52685-52800
405257 7329310 Plus 73121-73273 405475 1931025 Plus 1548-1702
TABLE 36A ABOUT 169 GENES UP-REGULATED IN KIDNEY CANCER
Table 36A lists about 169 genes up-regulated in kidney cancer compared to normal kidney that are likely to be extrxellular or cell surfxe proteins These were selxted as for Table
35A and the predicted protein contained a structural domain that is indicadve of surface or extracellular localization (e g ig fn3, egf 7tm domains) Predicted protein domains are noted
Pkey Unique Eos probeset identifier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Tide Unigene gene dfle
PSDoman Protein Structural Domain
R1 Rado of tumor to normal dssue
Pkey ExAccn UnigenelD Unigene Title PSDoman Rl
424704 AI263293 Hs 152096 cytochrome P450 SS,p450 409
426559 AB001914 Hs 170414 paired basic am TM,Pepddase.S8,P 356
458079 AI796870 Hs 54277 ESTs TM 346
446921 AB012113 Hs 16530 small inducible SS.IL8 259
452401 NM 007115 Hs 29352 tumor necrosis TM,SS,Xlιnk,CUB 248
414821 M63835 Hs 77424 Fc fragment of TM.SS ig 234
414812 X72755 Hs 77367 monokine induce SS.IL8 221
426471 M22440 Hs 170009 transforming gr TM.SS.EGF 21 3
449523 NM 000579 Hs 54443 chemokine (C-C TM,7tm 1 207
428227 AA321649 Hs 2248 small inducible IL8 195
456804 AI421645 Hs 139851 caveoliπ 2 TM.Caveolm 178
411642 NM 014932 Hs 71132 neuroligin 1 TM.SS.COesterase 16 2
427581 NM 014788 Hs 179703 KIAA0129 gene p TM 156
448520 AB002367 Hs 21355 doublecortin an TM.pkmase 148
417308 H60720 Hs 81892 KIAA0101 gene p TM 14 8
421566 NM 000399 Hs 1395 early growth re TM,zf-C2H2 146
422603 BE242587 Hs 118651 hematopoiedcal TM.SS.homeobox 14 4
425984 AW836277 Hs 165636 hypothedcal pr TM 14 2
432606 NM 002104 Hs 3066 granzyme K (ser TM SS trypsin 14 1
458809 AW972512 Hs 20985 sιπ3-assocιated SS 137
446627 AI973016 Hs 15725 hypothedcal pr TM 136
452960 AK001335 Hs 31137 Homo sapiens cD TM,Y_phosphatase 133
420552 AK000492 Hs 98806 hypothedcal pr TM.SS 130
425188 AK002052 Hs 155071 hypothetical pr TM 126
419034 NM 002110 Hs 89555 hemopoiedc cel TM,pkιnase,SH2 SH3 123
442932 AA457211 Hs 8858 bromodomain ad| TM.bromodomam PHD 12 3
434398 AA121098 Hs 3838 serυm-mducible TM,pkιnase,POLO_box 122
450506 NM 004460 Hs 418 fibroblast xd SS.DPPIV N term.Pepddase S9 12 1
425782 U66468 Hs 159525 cell growth reg SS 120
426108 AA622037 Hs 166468 programmed cell TM.DUF122 11 9
450236 AW162998 Hs 24684 KIAA1376 protei TM.SS 11 7
452838 U65011 Hs 30743 preferentially TM 11 2
426780 BE242284 Hs 172199 adenylate cycla TM.guanylate eye 11 1
415323 BE269352 Hs 949 neutrophil cyto TM.SH3.TPR 11 0
423508 AW604297 Hs 129711 hepatitis A vir TM.SS ig 11 0
408380 AF123050 Hs 44532 diubiquidn TM,ubιquιtιn,7tm 3.ANF receptor,sushι,7tm_1 11 0
448410 AK000227 Hs 21126 hypothetical pr TM 11 0
451277 AK001123 Hs 26176 hypothedcal pr TM 10 8
453165 S74727 Hs 32042 aspartoxylase TM 108
418036 Z37976 Hs 83337 latent transfer SS.TB EGF 105
431512 BE270734 Hs 2795 Ixtate dehydro TM,ldh 103
433862 D86960 Hs 3610 KIAA0205 gene p TM.SS 103
431211 M86849 Hs 5566 gap junction pr TM.connexin 102
432579 AF043244 Hs 278439 nucleolar prote TM 100
439653 AW021103 Hs 6631 hypothedcal pr TM.SS 99
428862 NM 000346 Hs 2316 SRY (sex-determ TM.HMG box 98
410762 AF226053 Hs 66170 HSKM-B protein SS zf-MYND 98
452431 U88879 Hs 29499 toll-like recep TM SS TIRLRRCT 95
405121 AB028989 Hs 88500 mitogen-xtivat SS.vwa vwd.TIL.Cys knotvwc 95
449625 NM 014253 Hs 23796 odz (odd Oz/ten SH2.EGF 94
421659 NM 014459 Hs 106511 protocadhenn 1 TM.SS.cadheππ 92
427283 AU 19796 Hs 174185 xtonucleotide TM.SS.Phosphodiest.Somatomedin B 9 1
407975 X89426 Hs 41716 endothelial cel SS.IGFBP 89
413554 AA319146 Hs 75426 sxretogranm I TM.SS.Granm 86
418693 AI750878 Hs 87409 thrombospondin EGF,TSPN,tsp_1,tsp_3,vwc 86
437672 AW748265 Hs 5741 flavohemoprotei TM.heme 1,oxιdored fad.Cyt reductase 86
430268 AK000737 Hs 237480 hypothetical pr TM SS 85
447850 AB018298 Hs 19822 SEC24 (S cerev TM 84
435717 AF227905 Hs 105794 UDP-glucose gly TM.GIyco.transf 8 83
433376 AI249361 Hs 74122 caspase 4, apop TM,ICE_p20,ICE_p10.CARD 82
419490 NM.006144 Hs 90708 granzyme A (gra TM,SS,trγpsιn 82
453033 AA325869 Hs 31463 KIAA0281 gene p TM 82
432328 AI572739 Hs 195471 6-phosphofructo TM.6PF2K.PGAM 79
413719 BE439580 Hs 75498 small inducible SS.IL8 79
412448 L12964 Hs 73895 tumor necrosis TM.SS.TNFR c6 79
424247 X14008 Hs 234734 lysozyme (renal SS Iys 78
421991 NM.01 918 Hs 110488 KIAA0990 protei SS 78
400793 AA635062 Hs 50094 Homo sapiens mR TM,BIR,CARDzf C3HC4 77 414646 AA353776 Hs 901 CD48 andgen (B TM,ιg 76
418372 AA311833 Hs 84318 replication pro TM 76
408418 AW963897 Hs 44743 KIAA1435 protei TM,WD40,FYVE 76
425354 U62027 Hs 155935 complement comp TM,7tm.1 75
432753 NM_014075 Hs 278915 PRO0593 protein TM.pkmase 74
447046 AA326187 Hs 17170 G protein-coupl TM,7tm_1 74
410577 X91911 Hs 64639 glioma pathogen TM.SCP 74
422631 BE218919 Hs 118793 hypothedcal pr TM 73
417022 NM 014737 Hs 80905 Ras association TM.RA 72
430105 X70297 Hs 2540 chotinergic rx TM,neur_chan 72
451621 AI879148 Hs 26770 fatty xid bind TM,SS,lιpocalιn 72
415138 C18356 Hs 78045 dssue fxtor p Kunιtz_BPTI,G-gamma 72
426028 NM 001110 Hs 172028 a dismtegnn a TM.SS,dιsιntegπn,Reprolysιn 72
434096 AW662958 Hs 75825 pleiomorphic ad TM,zf-C2H2 7 1
426423 NM 012446 Hs 169833 single-stranded TM 7 1
412783 BE276738 Hs 74578 DEAD/H (Asp-Glu TM,dsrm,helιcase C 7 1
431556 AF016028 Hs 260039 sarcospan (Kras TM 69
420018 U56387 Hs 94376 proprotein conv TM,SS,Peptιdase S8.P 69
444042 NM 004915 Hs 10237 ATP-bmding eas TM,ABC_traπ 69
432656 NM 000246 Hs 3076 MHC class II tr TM.LRR 69
430066 AI929659 Hs 237825 signal recognit TMJPR 69
401539 TM,SS,zf-B box,zf-C3HC4,Lysyl oxidase 68
416058 L08895 Hs 78995 MADS box transc TM.SRF-TF 68
413249 AF167160 Hs 75251 DEAD/H (Asp-Glu TM.SAP 67
424063 NM 002019 Hs 138671 fms-related tyr TM,SS,pkιnase,ιg 67
418026 BE379727 Hs 83213 fatty xid bind TM,SS,lιpocalιn 66
438619 AB032773 Hs 6341 TU12B1-TY prote TM 66
408741 M73720 Hs 646 carboxypepddas SS,Zn_carbOpeptPropep_M14 66
403549 TM.pkmase 66
435798 BE395289 Hs 12720 elF4E-fransport TM 66
453070 AK001465 Hs 31575 SEC63, endoplas TM.SS.DπaJ 66
452092 BE245374 Hs 27842 hypothedcal pr TM.SS.Acyltransferase 65
437396 BE140396 Hs 21621 hypothedcal pr TM 64
402474 TM.Pepddase C1 64
401600 BE247275 Hs 151787 U5snRNP-spxιf TM.SS.HECT 64
415076 NM 000857 Hs 77890 guanylate cycla TM.guanylate eye 64
430335 D80007 Hs 239499 KIAA0185 protei TM.S1 63
434203 BE262677 Hs 283558 hypothedcal pr TM 62
430287 AW182459 Hs 125759 ESTs, Weakly si TM.SS 62
417259 AW903838 Hs 81800 chondroidn sul TM,Xlιnk,tecdn c,sushι,EGF,ιg 61
421202 AF193339 Hs 102506 eukaryodc tran TM.SS 6 1
452235 AL039743 Hs 28514 Homo sapiens mR TM 60
429653 NM 005955 Hs 211581 metal-regulator TM,zf-C2H2 60
444484 AK002126 Hs 11260 hypothetical pr TM 59
410193 AJ132592 Hs 59757 zinc finger pro TM,zf-C2H2 59
425361 AA355933 Hs 132221 Homo sapiens cD TM 59
410361 BE391804 Hs 62661 guanylate bindi TM.SS.GBP 58
415714 NM 002290 Hs 78672 laminin, alpha TM.SS.Iaminm G.laminin EGF 58
421689 N87820 Hs 106826 hypothetical pr TM.SS.PHD 58
443837 AI984625 Hs 9884 spindle pole bo SS 58
422544 AB018259 Hs 118140 KIAA0716 gene p TM 57
412584 X54870 Hs 74085 DNA segment on TM,lecdπ_c 57
410425 BE278367 Hs 63510 KIAA0141 gene p TM 57
426283 NM 003937 Hs 169139 kynurenmase (L TM 57
430440 X52599 Hs 2561 nerve growth fa TM.SS.NGF 57
413551 BE242639 Hs 75425 ubiquitin assoc TM,SS,UBA 57
418250 U29926 Hs 83918 adenosine monop TM,A deaminase 56
419839 U24577 Hs 93304 phospholipase A SS 56
430253 AK001514 Hs 236844 hypothedcal pr TM 56
450447 AF212223 Hs 25010 hypothedcal pr TM.ANF receptor.guanylate cyc.pkinase 56
414020 NM 002984 Hs 75703 small inducible SS.IL8 56
414844 AA296874 Hs 77494 deoxyguanosme SS.dNK 56
416498 U33632 Hs 79351 potassium chann TM 56
430512 AF182294 Hs 241578 U6 sπRNA-assoα SS 56
419929 U90268 Hs 93810 cerebral cavern SS.ank.Band 41 55
407094 AF000574 Hs 22405 leukxyte immun TM,SS,ιg 55
411653 AF070578 HS 71168 Homo sapiens cl TM,SS,Aa trans 55
452355 N54926 Hs 29202 G protein-coupl TM,7tm_1 55
440486 BE243513 Hs 7212 hypothetical pr TM 55
444825 AW167613 Hs 248 mitogen-xdvat TM.SS.pk ase 55
447072 D61594 Hs 17279 tyrosylprotem SS 54
453392 U23752 Hs 32964 SRY (sex determ TM.HMG box 54
411213 AA676939 Hs 69285 neuropilin 1 TM,CUB,F5.F8_type_C,MAM 54
429688 BE245169 Hs 211610 CUG triplet rep TM.rrm 54
405257 TM 54
414911 NM 000107 Hs 77602 damage-specific TM.WD40 53
430598 AKG01764 Hs 247112 hypothetical pr TM 53
428753 AW939252 Hs 192927 hypothedcal pr TM.SS 53
406625 Y13647 Hs 119597 stearoyl-CoAde TM.Desaturase 53
405475 TM.suga tr 53
430180 AA331406 Hs 75456 A kinase (PRKA) TM 53
417381 AF164142 Hs 82042 solute earner TM,xan_ur_permease 53
433029 NM 014322 Hs 279926 opsin 3 (enceph TM,7tm_1 53 417355 D13168 Hs 82002 endothelin rece TM,SS,7tm_1,zf-C3HC4 53
412420 AL035668 Hs 73853 bone morphogene SS,TGFb_propepdde,TGF-beta 52
416975 NM 004131 Hs 1051 granzyme B (gra SS.tiγpsm 52
451418 BE387790 Hs 26369 hypothetical pr TM 52
425322 U63630 Hs 155637 protem kinase, TM,MCM,FAT,FATC,PI3.PI4.kιnase 52
415910 U20350 Hs 78913 chemokine (C-X3 TM,7tm_1 52
428593 AW207440 Hs 185973 degeneradve sp TM 52
417696 BE241624 Hs 82401 CD69 antigen (p TM.Ixdn c 52
442991 BE281238 Hs 8886 hypothetical pr TM 52
420567 AK000812 Hs 98874 similar to prol TM 5 1
412676 NM 000165 Hs 74471 gap juncdon pr TM.connexin 5 1
423430 AF112481 Hs 128501 RAD54, S cerev TM.SNF2 N,helιcase_C 5 1
421633 AF121860 Hs 106260 sorting nexin 1 TM.PX 5 1
436943 AA773838 Hs 5353 caspase 10, apo TM,ICE_p10,ICE_p20,DED 5 1
414696 AF002020 Hs 76918 Niemann-Pick di TM.SS.Patched 5 1
446312 BE087853 gb QV1-BT0681-2 TM 50
420397 NM 007018 Hs 97437 centrosomal pro TM 50
410274 AA381807 Hs 61762 hypoxia-inducib SS 50
TABLE 36B"
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT number Accession
446312 671114.1 BE087853 AI286184
TABLE 36C
Pkey Unique number coi responding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham et al " i sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted
NLposidon Indicates nudeodde positions of predicted exons
Pkey Ref Strand NLposidon
401539 8072433 Minus 62028-62608
402474 7547175 Minus 53526 53628,55755-5592057530-57757
403549 8081591 Minus 137150-137362
405257 7329310 Plus 73121-73273
405475 1931025 Plus 1548-1702
TABLE 37A ABOUT 280 GENES DOWN-REGULATED IN KIDNEY CANCER
Table 37A lists about 280 genes significantly down regulated in kidney cancer φmpared to normal kidney These were selxted as for Table 35A except that the numerator and denominator were switched
Pkey Unique Eos probeset identifier number
ExAccn Exemplar Accession number Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dde R1 Ratio of normal to tumor tissue
Pkey ExAccn UnigenelD UnigeneTitle R1
425260 L47726 Hs 1870 phenylalanine hydroxylase 5020
445635 AI769774 Hs 209831 ESTs Weakly similar to ALU 1 HUMAN ALU S 48 14
440243 BE301029 Hs 226422 ESTs 42 54
431657 AI345227 Hs 105448 ESTs, Weakly similar to B34087 hypotheti 40 14
441120 AI632015 Hs 164492 ESTs 3456
432488 AA551010 Hs 216640 ESTs 33 16
416854 H40164 Hs 80296 Purkmje cell protein 4 3206
438452 AI220911 Hs 288959 Homo sapiens cDNA FU20920 fis, clone A 29 54
414523 AU076633 Hs 76353 serine (or cysteine) proteinase iπhibito 2826
430250 NM 016929 Hs 283021 chloride intrxellular channel 5 28 16
446795 AI797713 Hs 156471 ESTs 27 23
451949 U03884 Hs 463 potassium inwardly-recdfying channel, s 2698
432128 AA127221 Hs 117037 ESTs 2654
448178 AI479482 Hs 170789 ESTs 2542
436639 D14838 Hs 111 fibroblast growth fxtor 9 (glia-xdvat 2399
426770 AI948618 Hs 150178 ESTs 2378
428839 AI767756 Hs 82302 ESTs 2304
431124 AF284221 Hs 59506 doublesex and mab-3 related franscnpdo 22 38
413333 M74028 Hs 75297 fibroblast growth fxtor 1 (xidic) 22 28
437575 AW954355 Hs 36529 ESTs 22 14
451062 AU 10125 Hs 25910 Homo sapiens mRNA, cDNA DKFZp564C1416 (f 22 12
447350 AI375572 Hs 172634 ESTs 2040
425920 AL049977 Hs 162209 claudin 8 2030
446293 AI420213 Hs 149722 ESTs 1948
425075 AA506324 Hs 1852 xid phosphatase prostate 19 10
418318 U47732 Hs 84072 transmembrane 4 superfamily member 3 1874
430130 AU 37311 Hs 234074 Homo sapiens mRNA, cDNA DKFZp761G02121 ( 18 56
441560 F13386 Hs 7888 Homo sapiens clone 23736 mRNA sequence 17 40
434880 U02388 Hs 101 cytochrome P450, subfamily IVF, polypept 1730
406667 M12523 Hs 75442 albumin 1706
414602 AW630088 Hs 76550 Homo sapiens mRNA, cDNA DKFZp564B1264 (f 1654 418021 M15881 Hs 1137 uromodul (uromucoid, Tamm-Horsfall gly 16 11
410681 AW246890 Hs 65425 calbmdin 1, (28kD) 1584
443324 R44013 Hs 164225 ESTs 1568
421285 NM 000102 Hs 1363 cytochrome P450, subfamily XVII (steroid 1546
436637 AI783629 Hs 26766 ESTs 15 18
448406 AW772298 Hs 21103 Homo sapiens mRNA, cDNA DKFZp564B076 (fr 14 52
434874 N62448 Hs 135906 ESTs 1446
407744 AB020629 Hs 38095 ATP-bmding cassette, sub-family A (ABC1 1384
453685 AL110309 gb DKFZp564L0278_r1 564 (synonym hfbr2) 1348
451939 U80456 Hs 27311 single-minded (Drosophila) homolog 2 1324
436624 T64297 Hs 5241 fatty xid binding protein 1, liver 1305
428931 AA994979 Hs 98967 ATPase H(ι-)-transpordng, lysosomal, no 1297
424823 NM 006226 Hs 153322 phospholipase C, epsilon 1266
431713 AK0 0388 Hs 267997 EHM2 gene 1266
436679 AI127483 Hs 120451 ESTs, Weakly simila to unnamed protein 1236
413859 AW992356 Hs 8364 pyruvate dehydrogenase kinase, isoenzyme 12 32
425707 AF115402 Hs 11713 E74-lιke fxtor 5 (ets doman transcπpt 11 92
440504 AI948966 Hs 130017 ESTs, Weakly simila to VATX_HUMAN VACUO 11 66
417275 X63578 Hs 81849 pan/albumin 11 48
410929 H47233 Hs 30643 ESTs 11 40
427167 AI239607 Hs 99196 ESTs 11 34
445591 AI471866 Hs 149095 ESTs 11 30
443622 AI911527 Hs 11805 ESTs 11 23
438935 H40665 Hs 31564 ESTs 11 16
438461 AW075485 Hs 286049 phosphoseπne aminotransferase 11 00
415539 AI733881 Hs 72472 ESTs 1084
438081 H49546 Hs 298964 ESTs 976
421688 AK000307 Hs 106825 hypothedcal protein FU20300 974
407280 AI241296 Hs 145609 ESTs 971
427969 NM 001963 Hs 2230 epidermal growth fador (beta-urogastron 961
442448 AI733144 Hs 129611 ESTs 9 52
442308 AA989402 Hs 45194 ESTs 951
410467 AF102546 Hs 63931 dachshund (Drosophila) homolog 935
429469 M64590 Hs 27 glycine dehydrogenase (dxaboxylatmg. 9 32
418068 AW971155 Hs 293902 ESTs, Weakly similar to prolyl 4-hydroxy 931
459247 N46243 Hs 110373 ESTs 920
423629 AW021173 Hs 18612 Homo sapiens cDNA FLJ21909 fis, clone H 9 16
410247 AF181721 Hs 61345 RU2S 9 10
430573 AA744550 Hs 136345 ESTs 908
457411 AW085961 Hs 130093 ESTs 899
443790 NM 003500 Hs 9795 xyl-Coenzyme A oxidase 2, branched cha 892
435024 AI863518 Hs 127743 ESTs, Weakly similar to V-ATPase G-subun 876
435056 AW023337 Hs 5422 glycoprotein M6B 874
426451 AI908165 Hs 169946 GATA-biπdmg protein 3 850
450648 AI703366 Hs 26766 ESTs 838
426255 BE262530 Hs 2006 glutathione S-transferase M3 (brain) 831
431820 AW410408 Hs 271167 L-pipecolic xid oxidase 8 28
451027 AW519204 Hs 40808 ESTs 8 10
435823 R07856 Hs 16355 ESTs 806
429269 AA449013 Hs 99203 ESTs 802
438199 AW016531 Hs 122147 ESTs 794
442176 AA983764 Hs 128910 ESTs 794
450164 AI239923 Hs 30098 ESTs 786
445627 AW818475 Hs 7363 ESTs 785
445779 AI253104 Hs 189267 ESTs 7 82
407178 AA195651 Hs 104106 ESTs 768
426966 AI493134 Hs 159125 ESTs 768
445659 AW3OO508 Hs 149229 ESTs 7 50
403204 746
448037 AW195634 Hs 170401 ESTs 730
413589 AW452631 Hs 258811 coatomer protein complex subunit gamma 7 26
446063 AI720140 Hs 151079 ESTs 7 26
424626 AA344308 Hs 128427 ESTs 725
403381 7 16
414807 AI738616 Hs 77348 hydroxyprostaglandin dehydrogenase 15-(N 7 12
432102 AW015506 Hs 130730 ESTs 7 12
442315 AA173992 Hs 7956 ESTs 7 10
453698 AA037615 Hs 42746 ESTs 702
415003 M11437 Hs 77741 kinmogen 695
426418 M90464 Hs 169825 collagen, type IV, alpha 5 (Alport syndr 692
452883 X80031 Hs 150318 ESTs 688
408621 AI970672 Hs 46638 chromosome 11 open reading frame 8 676
410781 AI375672 Hs 165028 ESTs 6 74
424596 AB020639 Hs 151017 estrogen-related rxeptor gamma 666
441031 AI110684 Hs7645 fibππogen, B beta polypeptide 666
451099 R52795 Hs 25954 interieukin 13 rxeptor, alpha 2 664
437553 AI829935 Hs 130497 ESTs, Weakly similar to MAT8.HUMAN CHLOR 663
445286 U03886 Hs 264 GS2 gene 654
408427 AW194270 Hs 177236 ESTs 652
410442 X73424 Hs 63788 propionyl Coenzyme A carboxylase, beta p 646
457001 J03258 Hs 2062 vitamin D (1,25 dihydroxyvitamin D3) re 646
420205 AA256395 Hs 88156 ESTs 642
441364 AW450466 Hs 126830 i ESTs 636 425649 U30930 Hs 158540 UDP glycosyltransferase 8 (UDP-galxtose 634
405373 632
431322 AW970622 gb EST382704 MAGE resequences MAGK Homo 632
440094 AI651558 Hs 270372 ESTs 627
442764 AI762254 Hs 131122 ESTs 6 21
424433 H04607 Hs 9218 ESTs 620
415025 AW207091 Hs 72307 ESTs 6 16
428927 AA441837 Hs 90250 ESTs 616
439145 H67346 Hs 269187 ESTs 606
424683 N87519 Hs 27196 ESTs 604
415314 N88802 Hs 5422 glycoprotein M6B 594
424025 AI701852 Hs 301296 ESTs 590
445911 AI985987 Hs 145645 ESTs, Moderately similar to ALU1_HUMAN A 589
417332 AW972717 Hs 288462 Homo sapiens cDNA FU21511 fis, clone C 586
440102 AI672443 Hs 131190 ESTs 584
429609 AF002246 Hs 210863 cell adhesion molecule with homology to 582
411666 AF106564 Hs 71346 neurofilament 3 (150kD medium) 582
446224 AW450551 Hs 13308 ESTs 574
422305 AI928242 Hs 293438 ESTs, Highly similar to AF198488 1 trans 572
436802 N34486 Hs 170504 ESTs 572
412452 AA215731 Hs 283446 ESTs, Weakly similar to ALAT HUMAN ALANI 570
445611 AW418497 Hs 145583 ESTs 566
440038 AA861627 Hs 243989 ESTs 566
424028 AF055084 Hs 153692 KIAA0686 protein 561
410530 M25809 Hs 64173 ESTs, Highly simila to VAB1 HUMAN VACUO 560
425907 AA365752 Hs 155965 ESTs 560
428523 AW974540 Hs 98626 ESTs 558
429918 AW873986 Hs 119383 ESTs 558
408369 R38438 Hs 182575 solute earner family 15 (H+/pepdde tra 556
446163 AA026880 Hs 25252 Homo sapiens cDNA FU 13603 fis, clone PL 5 56
427398 AW390020 Hs 20415 chromosome 21 open reading frame 11 552
418504 BE159718 Hs 85335 Homo sapiens mRNA cDNA DKFZp564D1462 (f 551
440666 AA902650 Hs 192742 Homo sapiens cDNA FU 12785 fis, clone NT 550
432286 AW327432 Hs 255843 ESTs 548
451236 AI767406 Hs 207026 ESTs, Weakly similar to B56205 transcπp 546
422746 NM 004484 Hs 119651 glypican 3 543
416426 AA180256 Hs 210473 ESTs, Weakly simila to GELS_HUMAN GELSO 537
414449 AA557660 Hs 76152 dxoπn 536
445898 AF070623 Hs 13423 Homo sapiens clone 24468 mRNA sequence 534
451835 T63643 Hs 209715 ESTs, Weakly similar to ALU7.HUMAN ALU S 532
424566 M16801 Hs 1790 nuclear receptor subfamily 3, group C m 5 22
408604 D51408 Hs 21925 ESTs 518
456576 AA287443 gb zs52c10 r1 NCI CGAP GCB1 Homo sapiens 5 18
433212 BE218049 Hs 121820 ESTs 5 16
452114 N22687 Hs 8236 ESTs 5 14
458072 AI890347 Hs 271923 Homo sapiens cDNA FU22785 fis clone K 5 14
443005 AI027184 Hs 200918 ESTs 5 14
408554 AA836381 Hs 7323 ESTs 512
438609 T62870 Hs 291991 ESTs 5 10
429343 AK000785 Hs 199480 epsm 3 510
452223 AA425467 Hs 8035 ESTs 5 10
446925 AW974605 Hs 176669 ESTs 509
407664 AW063476 Hs 279080 ESTs 508
414664 AA587775 Hs 66295 Homo sapiens HSPC311 mRNA, partial eds 506
407978 AW385129 Hs 41717 phosphodiesterase 1A, calmodulin-depende 504
435343 AW194962 Hs 199028 ESTs 504
419150 T29618 Hs 89640 TEK tyrosine kinase endothelial (venous 504
442317 AI915599 Hs 129225 ESTs 502
404319 502
433637 AW024214 Hs 135405 ESTs 492
440205 T86950 Hs 188465 ESTs 484
432029 D31628 Hs 2899 4-hydroxyphenylpyruvate dioxygenase 483
453125 AW779544 Hs 115497 Homo sapiens cDNA FU22655 fis, clone H 480
407788 BE514982 Hs 38991 S100 calcium-binding protein A2 478
439750 AL359053 Hs 57664 Homo sapiens mRNA full length insert cDN 475
443633 AL031290 Hs 9654 similar to pregnancy-associated plasma p 4 74
449050 AW302858 Hs 187333 ESTs 469
422237 M13149 Hs 1498 hisddme-πch glycoprotein 467
442476 AF069475 gb AF069475 Homo sapiens astrocytoma lib 464
431130 NM 006103 Hs 2719 epididymis specific, whey-xidic protein 458
440624 AF017987 Hs 306 sxreted fπzzled-related protein 1 458
403046 451
450838 R65841 Hs 28653 ESTs 448
455887 BE154173 gb P 1 -HT0340-201299-004-f 12 HT0340 Homo 447
453500 AI478427 Hs 43125 ESTs 4 40
405701 437
426657 NM 015865 Hs 171731 solute earner family 14 (urea transport 437
451032 W03692 Hs 25832 Homo sapiens mRNA, cDNA DKFZp564P116 (fr 437
426200 AA371876 Hs 234786 KIAA0707 protein 4 35
418836 AI655499 Hs 161712 ESTs 434
447754 AW073310 Hs 163533 Homo sapiens cDNA FU14142 fis, clone MA 432
438209 AL120659 Hs 6111 KIAA0307 gene product 4 23
404559 422 413272 AA127923 Hs 293256 ESTs 421
423068 M25629 Hs 123107 kallikrein 1 renal/pancreas/salivary 4 19
416982 J05401 Hs 80691 creatine kinase, mitochondnal 2 (sarcom 418
445512 AI241246 Hs 148903 EST 4 17
445177 AI215070 Hs 16135 ESTs 4 16
448475 BE613134 Hs 247474 Homo sapiens cDNA FU21032 fis, clone C 4 14
402072 409
439285 AL133916 Hs 298998 ESTs 402
429621 AI823386 Hs 130874 Homo sapiens cDNA FU14181 fis, clone NT 399
450273 AW296454 Hs 24743 hypothetical protein FU20171 397
453511 AL031224 Hs 33102 transcnpdon fxtor AP-2 beta (xdvad 394
452620 AA436504 Hs 119286 ESTs 392
425642 X91220 Hs 158462 solute earner family 12 (sodium/chloπd 391
435884 AA701443 Hs 192868 ESTs 3.90
416889 AW250318 Hs 80395 mal, T-cell differentiation protein 389
419677 N77342 Hs 21851 Homo sapiens cDNA FU12900 fis, clone NT 388
431958 X63629 Hs 2877 cadheπn 3, type 1 , P-cadheπn (plxenta 384
456844 AI264155 Hs 152981 CDP-dixylglycerol synthase (phosphadda 382
442306 AI820660 Hs 129205 ESTs 382
438453 D17056 Hs 288959 Homo sapiens cDNA FU20920 fis, clone A 381
407198 H91679 gb yv04a07 s1 Soaes fetal liver spleen 380
431441 U81961 Hs 2794 sodium channel, nonvoltage-gated 1 alpha 379
413841 M34276 Hs 75576 plasmmogen 377
431161 AA493591 gb nh01a12s1 NCI CGAP Thy1 Homo sapiens 376
428544 AA430034 Hs 191611 ESTs 374
453903 AW299606 Hs 232777 ESTs 374
434061 AW024973 Hs 283675 NPD0O9 protein 373
444805 AB007899 Hs 1201 KIAA0439 protein, homolog of yeast ubiqu 373
440080 AW051597 Hs 143707 ESTs 371
440230 AI732970 Hs 126246 ESTs 370
428735 AJ279246 Hs 192657 NPHS2 gene (podocin) 368
421832 NM 016098 Hs 108725 HSPC040 protein 366
430135 NM 000035 Hs 234234 aldolase B, fructose-bisphosphate 365
453055 AW291436 Hs 31917 ESTs 365
450696 AI654223 Hs 16026 Homo sapiens cDNA FU23191 fis clone L 359
440232 AI766925 Hs 112554 ESTs 357
432099 U20760 Hs 272429 calcium-sensing rxeptor (hyp∞alciuπc 357
445924 AI264671 Hs 164166 ESTs 356
411356 H45377 gb yn99h03 r1 Soares adult brain N2b5HB5 356
431103 M57399 Hs 44 pleiotrophm (hepann binding growth fx 3 55
413752 BE161807 gb MR3-HT0446-300300-203-h01 HT0446 Homo 353
416298 NM 003891 Hs 1011 protein Z, vitamin K-dependent plasma gl 353
423603 AB007880 Hs 129883 KIAA0420 gene product 353
436610 AW611912 Hs 120414 ESTs 350
425905 AB032959 Hs 161700 KIAA1133 protein 348
403625 347
425210 AA054679 Hs 155150 πbonuclease P (14kD) 345
430168 AW968343 Hs 300896 ESTs, Highly similar to AF128113 1 promi 342
448877 AI583696 Hs 253313 ESTs 340
456686 AI554303 Hs 35982 Homo sapiens cDNA FLJ12776 fis, clone NT 338
414725 AA769791 Hs 120355 Homo sapiens cDNA FU13148 fis, clone NT 337
453574 AI767947 Hs 50841 ESTs, Weakly similar to tuftelin [M muse 332
438535 L09078 gb Homo sapiens mRNA fragment 331
414040 N58513 Hs 32171 ESTs 330
451416 AW631469 Hs 203213 ESTs 330
444564 AI167877 Hs 143716 ESTs 329
408001 AA046458 Hs 95296 ESTs 3 27
406666 V00495 Hs 75442 albumin 324
421750 AK000768 Hs 107872 hypothedcal protein FU20761 324
445337 NM 013280 Hs 12523 fibronectin leucine πch transmembrane p 323
423968 AF098277 Hs 136529 solute earner family 23 (nucleobase tra 321
427209 H06509 Hs 92423 KIAA1566 protein 320
403442 320
419713 AW968058 Hs 92381 nudix (nucleoside diphosphate linked moi 3 19
425548 AA890023 Hs 1906 prolxtin rxeptor 317
414502 AL133721 Hs 224680 ESTs 316
427811 M81057 Hs 180884 cartooxypepbdase B1 (dssue) 3 14
436330 NM 004413 Hs 109 dipeptidase 1 (renal) 311
433942 AW272166 Hs 123465 ESTs 3 11
408692 AL040127 Hs 34074 dipepddylpepddase VI 310
448819 AI589190 Hs 188372 ESTs 3 10
423041 BE170842 Hs 123123 chlonde channel Ka 3 10
454554 AW847505 gb RC0-CT0210-280999-021-C10 CT0210 Homo 3 10
406664 L34041 Hs 25478 glyeerol-3-phosphate dehydrogenase 1 (so 310
449850 AW206292 Hs 199751 ESTs 308
427450 AB014526 Hs 178121 KIAA0626 gene product 308
454788 AW820691 gb RC5-ST0300-300100-012-H06 ST0300 Homo 306
444895 AI674383 Hs 301192 ESTs 306
457782 N54493 gb yv40g05 s1 Soares fetal liver spleen 305
429023 NM 000312 Hs 2351 protein C (inxdvator of coagulation fa 305
427041 AI693661 Hs 97557 ESTs 301
434788 AF154121 Hs 102867 sodium-dependent high-affinity dicaboxy 301
419003 T78640 Hs 268595 ESTs 301 TABLE 37B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank xcession numbers
Pkey CAT number Accession
411356 1240273 1 H45377H21137AW838640
413752 1386338 1 BE161807 BE161584 BE161700 BE161748
431161 328713 1 AA493591 AA829120AA533792
431322 331543 1 AW970622 AA503009 AA502998 AA502989 AA502805 T92188
438535 45946.1 L09078 L03145 L09094 L09098 L03165 L09102
442476 543547 1 AF069475 AF069477 AF069476
453685 977734 1 AL110309 AW088119 H22881
454554 1223842 1 AW847505 AW811792 BE061442 BE061433 AW847506 AW806999AW806996 BE061436 BE061430 BE142460 BE146499 AW806994 AW809156
AW806991 AW814082 AW806992 BE061669 AW807002 BE146659 AW806995 AW807000 AW845743 AW845747 AW847504 BE142458 BE061431
BE061435 AW847507 BE146650 BE142470 AW814096 AW807012 BE061438 AW807011 AW806993 BE142465 BE142459 BE142462 AW854330
AW854331 BE061434 BE061731 BE142464 AW847501 AW807001 BE142463 AW811800 BE061437 AW811802 BE061440 AW806997 AW806998
BE061745 BE061753
454788 1234694 -1 AW820691
455887 1380836 1 BE154173 BE154098BE154096
456576 201378 1 AA287443 AA419385 BE084078 AI47834
457782 405265 1 N54493AA679039 76605
407198 H91679
TABLE 37C
Pkey Unique Eos probeset idendfier number
Ref reference gi ID
Strand strand identification
NLposidon i chromosomal nudeodde position
Pkey Ref Strand Nt position
402072 8117363 Plus 71983-72128
403046 3540153 Minus 55707-55859,56369-56511
403204 7622392 Plus 16214-16439
403381 9438267 Minus 26009-26178
403442 7210003 Plus 174560-175270
403625 8569879 Plus 6551-7111
404319 9211467 Plus 54436-54608
404559 8748893 Minus 73499-73651,89575-89739
405373 2076718 Plus 21294-21575
405701 4263751 Plus 93243-93364 TABLE 38A ABOUT 860 GENES UP-REGULATED IN KIDNEY CANCER COMPARED TO NORMAL ADULT TISSUES
Table 38A lists about 860 genes up-regulated in kidney cancer compared to normal adult tissues These were selxted from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip anay such that the rado of 'average* kidney cancer to "average* normal adult dssues was greater than or equal to 30 The "average* kidney cancer level was set to the 90th percendle amongst vanous kidney cancers The "average* normal adult dssue level was set to the 70th percendle amongst vaπous non malignant tissues In order to remove gene- specific bxkground levels of non-spxific hybndizadon, the 15th percendle value amongst vanous non-malignant tissues was subtrxted from both the numerator and the denominator before the rado was evaluated
Pkey Unique Eos probeset idendfier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Tide Unigene gene title R1 Rado of tumor to normal adult dssues
Pkey ExAccn UnigenelD Unigene Title R1
435013 H91923 Hs 110024 1571
447768 X86400 Hs 19520 Hs 19520 FXYD domain-containing ion tran 1407
445178 AI792241 Hs 129614 Hs 129614 kidney-specific membrane prote 1256
432542 AW083920 Hs 16098 Hs 16098 claudin 2 1241
443595 AF169312 Hs 9613 NM_016109 Homo sapiens angiopoiedn-like 11 77
413719 BE439580 Hs 75498 NM.004591 Homo sapiens small inducible c 1039
436878 BE465204 Hs 7448 Hs 47448 ESTs 1018
440304 BE159984 Hs 125395 Hs 125395 ESTs 995
407065 Y10141 958
413049 NM.002151 Hs 823 NM.002151 Homo sapiens hepsin (transmemb 951
425983 AK000226 Hs 165619 Hs 165619 mucin and cadhenπ-like 888
423161 AL049227 Hs 124776 Hs 124776 Homo sapiens mR, cD DKFZp564N1 877
430569 AF241254 Hs 178098 Hs 178098 angiotensm I converting eπzym 845
416768 AA363733 Hs 1032 NM.002909 Homo sapiens regenerating isle 794
422357 AF016272 Hs 115418 NM.004062 Homo sapiens cadheπn 16, KSP- 778
420737 L08096 Hs 99899 NM.001252 Homo sapiens tumor nxrosis fa 778
409745 AA077391 AA077391 7B14E 12 Chromosome 7 Fetal Bra 774
413936 AF113676 Hs 297681 NM.000295 Homo sapiens senne (or cystei 732
426682 AV660038 Hs 2056 Hs 2056 UDP glycosyltransferase 1 family 720
406851 AA609784 Hs 352392 Hs 352392 mapr histocompadbility compl 703
419508 AW997938 Hs 90786 Hs 90786 ATP-bmding cassette, sub-famil 657
428953 AA306610 Hs 348183 NM.003823 Homo sapiens tumor nxrosis fa 636
436895 AF037335 Hs 5338 NM_001218 Homo sapiens carbonic anhydras 631
431842 NM 005764 Hs 271473 NM_005764 Homo sapiens epithelial protei 620
430014 H59354 Hs 374303 Hs 374303 hypothetical protein MGC20576 620
423803 NM 005709 Hs 132945 NM_005709 Homo sapiens PDZ-73 protein (P 619 434779 AF153815 Hs 50151 Hs 50151 potassium inwardly-recdfying c 6 11
435767 H73505 Hs 117874 Hs 117874 ESTs 608
422664 AA315933 Hs 120879 Hs 120879 Homo sapiens, done MGC 32871 602
425280 U31519 Hs 1872 Hs 1872 phosphoenolpyruvate carboxykise 581
426559 AB001914 Hs 170414 NM.002570 Homo sapiens paired basic amm 573
451564 AU076698 Hs 132760 NM_001467 Homo sapiens glucose-6-phospha 569
418526 BE019020 Hs 85838 NM.0O4207 Homo sapiens solute earner fa 568
444151 AW972917 Hs 128749 Hs 128749 alpha-methylxyl-CoA rxemase 566
426471 M22440 Hs 170009 NM_003236 Homo sapiens transforming grow 548
432579 AF043244 Hs 278439 NM_003946 Homo sapiens πucleolar protein 545
448733 NM_005629 Hs 187958 NM_005629 Homo sapiens solute earner fa 542
446650 AB016625 Hs 15813 NM_003060 Homo sapiens solute earner fa 536
417089 H52280 Hs 18612 Hs 18612 Homo sapiens ct FU21909 fis, 535
437848 AI906419 Hs 284380 Hs 284380 gamma-glutamyltransferase 1 532
423081 AF262992 Hs 123159 Hs 123159 sperm associated andgen 4 530
421893 NM 001078 Hs 109225 NM_0O1078 Homo sapiens vascular cell adh 523
435886 BE265839 Hs 12126 Hs 12126 hepatocellula caranoma-ass∞i 520
410276 AI554545 Hs 359201 Hs 359201 ESTs 520
429451 BE409861 Hs 202833 NM_002133 Homo sapiens heme oxygese (dx 5 14
446404 AA019961 Hs 26216 Hs 26216 Homo sapiens cD FU22811 fis, 5 13
423445 NM.014324 Hs 128749 NM_014324 Homo sapiens alpha-methylxyl- 509
449444 AW818436 Hs 351306 NM_004696 Homo sapiens solute earner fa 505
438106 BE245551 Hs 6079 NM_014863 Homo sapiens B cell RAG associ 502
400419 AF084545 AF084545 Homo sapiens versican Vint isof 501
453920 AI133148 Hs 36602 NM_0O0204 Homo sapiens I fxtor (complem 499
447881 BE620886 Hs 355279 Hs 355279 Homo sapiens cD FU23711 fis, 497
422253 W81526 Hs 113882 NM_000815 Homo sapiens gamma-ammobutyπ 493
439024 R96696 Hs 35598 Hs 35598 ESTs 488
414799 AI752416 Hs 77326 NM_000598 Homo sapiens insulin-like grow 480
426530 U24578 Hs 278625 NM_000592 Homo sapiens complement compon 477
410055 AJ250839 Hs 58241 Hs 58241 gene for seπne/threonine prote 4 72
404240 4 71
414617 AI339520 Hs 288817 Hs 288817 hypothetical protein FLJ22761 4 68
448249 AW855331 Hs 337124 Hs 337124 ESTs 467
447818 W79940 Hs 21906 Hs 21906 Homo sapiens clone 24670 mR seq 4 66
449057 AB037784 Hs 22941 Hs 22941 KIAA1363 protein 466
422424 AI186431 Hs 296638 NM_004864 Homo sapiens prostate differen 462
417336 R70429 Hs 81988 NM_001343-Homo sapiens disabled homolog 4 62
425873 NM 013390 Hs 160417 NM_013390 Homo sapiens transmembrane pro 4 58
444700 NM_003645 Hs 11729 NM_0O3645 Homo sapiens fatty-xid-Coenzy 458
414998 NM 002543 Hs 77729 NM.002543 Homo sapiens oxidised low dens 456
414763 U97276 Hs 77266 NM_0O2826 Homo sapiens quiescm Q6 (QSCN 448
443358 H65417 Hs 17757 Hs 17757 pleckstnn homology doman-cont 445
440091 AI767388 Hs 37890 Hs 37890 Homo sapiens, clone IMAGE 48275 443
447131 NM 004585 Hs 17466 NM_004585 Homo sapiens rednoic xid rx 443
406973 M34996 Hs 198253 Hs 198253 major histocompadbility compl 442
427740 BE242604 Hs 180616 NM.005505 Homo sapiens CD36 antigen (col 4 40
436258 AW867491 Hs 107125 Hs 107125 plasmalemma vesicle associated 438
452884 C05964 Hs 31841 Hs 31841 ESTs 437
444006 BE395085 Hs 10086 NM.016639 Homo sapiens type I transmembr 436
422627 BE336857 Hs 118787 NM.000358 Homo sapiens transforming grow 435
418054 NM 002318 Hs 83354 NM.002318 Homo sapiens lysyl oxidase- k 434
419011 H56244 Hs 89552 NM_O00846 Homo sapiens glutathione S-tra 434
404277 4 33
435563 AF210317 Hs 95497 Hs 95497 solute earner family 2 (fxili 430
431779 AW971178 Hs 268571 NM_001645 Homo sapiens apolipoprotein C- 4 29
406645 M57466 Hs 814 Hs 814 major histocompadbility complex, 4 28
421485 AA243499 Hs 104800 Hs 104800 hypothetical protein FU10134 426
426812 AF105365 Hs 172613 NM_006598 Homo sapiens solute earner fa 4 25
407910 AA650274 Hs 41296 NM 013281 Homo sapiens fibronxtin leuci 422
438030 X98427 Hs 122634 Hs 122634 ESTs 4 22
430661 AC005551 Hs 130714 Hs 130714 ESTs, Moderately similar to AF 4 21
444381 BE387335 Hs 283713 Hs 283713 hypothedcal protein BC014245 420
438203 BE540090 Hs 7345 Hs 7345 MAD1 mitodc arest deficient-li 4 16
411358 R47479 Hs 94761 Hs 94761 KIAA1691 protein ,4 15
418323 NM.002118 Hs 1162 NM.002118 Homo sapiens major histocompat 4 12
449853 AF006823 Hs 24040 NM_002246 Homo sapiens potassium channel 4 11
415198 AW009480 Hs 943 NM_004221 Homo sapiens tural killer cell 4 11
418751 BE389014 Hs 372548 Hs 372548 phosphoιnosιdde-3-kιse, regul 409
414166 AW888941 Hs 75789 NM_006096 Homo sapiens N-myc downstream 407
424125 M31669 Hs 1735 Hs 1735 mhibiπ, beta B (xdvm AB beta 400
416926 H03109 Hs 263395 Hs 263395 sema domain, transmembrane dom 392
419175 AW270037 Hs 362996 Hs 362996 KIAA0779 protein 392
424218 AF031824 Hs 143212 NM.003650 Homo sapiens cystadn F (leuko 391
412870 N22788 Hs 82407 Hs 82407 chemokine (C-X-C modf) hgand 388
452203 X57522 Hs 352018 NM.000593 Homo sapiens transporter 1, AT 387
446872 X97058 Hs 16362 NM_004154 Homo sapiens pyπmidinergic re 387
449961 AW265634 Hs 133100 Hs 133100 ESTs 387
424517 AI539443 Hs 137447 Hs 137447 Homo sapiens cD FU12169 fis, 386
425262 D87119 Hs 155418 Hs 155418 GS3955 protein 383
443639 BE269042 Hs 9661 NM.0O2801 Homo sapiens proteasome (proso 382
448133 AA723157 Hs 73769 NM.000802 Homo sapiens folate rxeptor 1 381
418030 BE207573 Hs 83321 Hs 83321 neuromedm B 381 412939 AW411491 Hs 75069 NM.005412 Homo sapiens senne hydroxymet 380
409162 H25530 Hs 50868 NM.002555 Homo sapiens solute earner fa 379
427715 BE245274 Hs 180428 Hs 180428 KIAA1181 protein 378
412006 AW451618 Hs 290216 Hs 290216 ESTs 377
430413 AW842182 Hs 241392 NM.002985 Homo sapiens small inducible c 376
422282 AF019225 Hs 114309 Hs 114309 apolipoprotein L, 1 376
420747 BE294407 Hs 99910 Hs 99910 phosphofructokise, platelet 376
414875 H42679 Hs 77522 NM_006120 Homo sapiens major hist∞ompat 375
418793 AW382987 Hs 88474 Hs 88474 prostaglandin-endoperoxide syπt 374
446291 BE397753 Hs 14623 NM_0O6332 Homo sapiens interferon, gamma 371
417289 D86962 Hs 81875 Hs 81875 growth fxtor receptor-bound pr 369
422672 X12784 Hs 119129 NM W1845 Homo sapiens collagen, type IV 368
448569 BE382657 Hs 21486 NM_007315 Homo sapiens sigl transducer a 368
437270 R18087 Hs 323769 Hs 323769 cispladn resistance related p 367
408452 AA054683 Hs 192455 Hs 192455 ESTs, Moderately simila to hy 367
443986 AI381750 Hs 283437 Hs 283437 HTGN29 protein 366
418869 AW516565 AW516565 xq01d05 x1 Soaes_NHCeC_ceιvιca 365
425998 AU076629 Hs 165950 NM_002011 Homo sapiens fibroblast growth 362
428699 AW578252 Hs 190161 NM_014020 Homo sapiens LR8 protein (LR8) 362
418299 AA279530 Hs 83968 NM.000211 Homo sapiens integnn, beta 2 361
432593 AW301003 Hs 51483 Hs 51483 Homo sapiens, Similar to RIKEN 359
415765 NM_005424 Hs 78824 NM.005424 Homo sapiens tyrosine kise wit 358
445985 BE621800 Hs 29444 Hs 29444 putadve small membrane protein 357
424893 AW295112 Hs 153648 Hs 153648 protein tyrosine phosphatase, 357
426046 AA833655 Hs 206868 Hs 206868 Homo sapiens cD FU14056 fis, 357
424415 NM 001975 Hs 146580 NM_001975 Homo sapiens enolase 2, (gamma 357
412612 NM_000047 Hs 74131 NM_000047 Homo sapiens arylsulfatase E ( 356
443834 AI741510 Hs 173548 Hs 173548 ESTs 354
431630 NM 002204 Hs 265829 NM.002204 Homo sapiens integnn, alpha 3 353
418371 M13560 Hs 84298 Hs 84298 CD74 andgen (invaπant polypep 352
444838 AV651680 Hs 208558 Hs 208558 ESTs 352
449378 AW664026 Hs 59892 Hs 59892 ESTs, Weakly similar to alpha 5 352
411393 AW797437 Hs 69771 NM_001710 Homo sapiens B-fxtor, properd 350
414311 AI693547 Hs 71746 Hs 71746 aminopepddase-like 1 350
415149 X12451 Hs 78056 NM_001912 Homo sapiens cathepsin L (CTSL 350
424321 W74048 Hs 1765 Hs 1765 lymph∞yte-spxific protein tyro 349
414825 X06370 Hs 77432 NM_0O5228 Homo sapiens epidermal growth 348
408194 AA601038 Hs 191797 Hs 191797 ESTs 348
410600 AW575742 Hs 351676 Hs 351676 ESTs, Weakly similar to T02670 347
416899 BE262645 Hs 8O420 NM.002996 Homo sapiens small inducible c 347
436856 AI469355 Hs 127310 Hs 127310 hypothedcal protein BC014917 347
419660 BE280337 Hs 194693 NM_003982 Homo sapiens solute earner fa 347
413566 AW604451 Hs 285814 Hs 285814 growth fxtor receptor-bound p 347
412104 AW205197 Hs 240951 Hs 240951 ked cuticle homolog 2 (Drosoph 346
444488 AW192879 Hs 355660 Hs 355660 pepdde-hisddme transporter 3 6
449475 AI348027 Hs 108557 Hs 108557 hypothedcal protein PP1057 346
412276 BE262621 Hs 73798 NM_002415 Homo sapiens mxrophage migrat 345
449338 H73444 Hs 394 NM_001124 Homo sapiens adreπomedullin (A 344
430304 AL122071 Hs 238927 Hs 238927 Homo sapiens mR, cD DKFZp434H1 343
415388 AF018081 Hs 78409 (lxuslmk)NM_030582 Homo sapiens collag 343
432210 AI567421 Hs 273330 Hs 273330 agnn 343
418177 N44967 Hs 351554 Hs 351554 Homo sapiens cD FU32092 fis, 342
414888 AL039185 Hs 77558 Hs 77558 thyroid hormone rxeptor intera 342
452445 AB002438 Hs 29596 Hs 29596 Homo sapiens mR from chromosome 341
414803 X03100 Hs 914 Hs 914 ma|or histocompadbility complex, 341
419201 M22324 Hs 1239 NM_001150 Homo sapiens alanyl (membrane) 341
445139 AB037848 Hs 12365 Hs 12365 syptotagmm XIII 341
435021 AA922192 Hs 73962 Hs 73962 EphA7 341
417259 AW903838 Hs 81800 Hs 81800 chondroidn sulfate proteoglyca 340
439737 AI751438 Hs 41271 Hs 41271 Homo sapiens mR full length ins 339
410636 AA088177 Hs 172870 Hs 172870 KIAA1913 protein 339
431590 AB037789 Hs 263395 Hs 263395 sema domain, transmembrane dom 338
415000 AW025529 Hs 239812 Hs 239812-serologιcally defined breast c 336
416700 AW498958 Hs 343475 NM_001909 Homo sapiens cathepsin D (lyso 336
440516 S42303 Hs 161 NM_001792 Homo sapiens cadhenn 2, type 335
423720 AL044191 Hs 23388 Hs 23388 hypothedcal protein DKFZp434F0 332
421902 BE392717 BE392717 601307571F1 NIH.MGC.44 Homo sap 332
409220 BE243323 Hs 51233 Hs 51233 tumor nxrosis fxtor rxeptor 332
421502 AF111856 Hs 105039 NM_006424 Homo sapiens solute caπer fa 332
416729 U46165 Hs 1027 NM_0 4165 Homo sapiens Ras-related assx 330
430302 AL137502 Hs 238679 Hs 238679 Rag D protein 330
445084 H38914 Hs 250848 Hs 250848 Homo sapiens cD FU14761 fis, 329
406825 AI982529 Hs 84298 Hs 84298 CD74 antigen (mvanaπt polypep 329
446272 BE268912 Hs 14601 NM_005335 Homo sapiens hematopoietic cel 328
437145 AF007216 Hs 5462 NM 003759 Homo sapiens solute earner fa 327
444071 AI627808 Hs 110524 Hs Ϊ10524 ESTs 327
414662 AL036058 Hs 76807 Hs 76807 major histxompatibility comple 3 27
436576 AI458213 Hs 77542 Hs 77542 ESTs. Weakly similar to S26650 326
424675 NM 005512 Hs 151641 NM_005512 Homo sapiens glycoprotein A re 325
437897 . 70561 Hs 146170 Hs 146170 hypothetical protein FU22969 325
449703 H61001 Hs 171802 Hs 171802 Homo sapiens, clone IMAGE 3956 325
414788 X78342 Hs 77313 NMJW3674 Homo sapiens cyclin-dependent 325
414249 AI797994 Hs 279929 Hs 279929 gp25L2 protein 324 430396 D49742 Hs 241363 NM.004132 Homo sapiens hyaluron binding 323
424456 AA341017 Hs 25549 Hs 25549 hypothetical protein FU20898 3 23
452303 R27257 Hs 57734 Hs 57734 G protein-coupled rxeptor kise 322
425390 AI092634 Hs 156114 NM.004648 Homo sapiens protein tyrosine 321
416033 NM 012201 Hs 78979 NM.O12201 Homo sapiens golgi apparatus p 3 19
450931 N25156 Hs 25648 Hs 25648 tumor nxrosis fxtor rxeptor 3 19
428065 AI634046 Hs 157313 Hs 157313 ESTs 3 18
422616 BE300330 Hs 118725 NM_012248 Homo sapiens selenophosphate s 3 18
439318 AW837046 Hs 6527 Hs 6527 G protein-coupled receptor 56 3 17
427640 AF058293 Hs 180015 NM_001355 Homo sapiens D-dopxhrome taut 3 17
409936 AK001691 Hs 57655 Hs 57655 dudulιn 2 3 16
436001 AW903849 Hs 173840 Hs 173840 similar to endothelial cell-se 3 16
451154 AA015879 Hs 33536 Hs 33536 ESTs 3 16
420256 U84722 Hs 76206 NM_001795 Homo sapiens cadheπn 5, type 3 16
407584 W25945 Hs 8173 Hs 8173 hypothetical protein FU10803 3 15
428593 AW207440 Hs 185973 NM_003676 Homo sapiens degeπeradve sper 3 15
410026 AI912061 Hs 55016 Hs 55016 EPS8-related protein 2 3 15
445333 BE537641 Hs 44278 Hs 44278 RA817, member RAS oncogene farm 3 14
448143 AF039704 Hs 20478 NM.000391 Homo sapiens ceroid-lipofuscin 314
423007 AA320134 Hs 196029 Hs 196029 Homo sapiens mR for KIAA1657 p 3 14
416511 NM 006762 Hs 79356 NM_006762 Homo sapiens Lysosomal-ass∞ia 3 14
439237 AW408158 Hs 318893 Hs 318893 ESTs, Weakly simila to Z195_H 3 13
446899 NM 005397 Hs 16426 NM_005397 Homo sapiens podxalyxin-like 3 13
413916 N49813 Hs 75615 NM_000483 Homo sapiens apolipoprotein C- 3 13
434398 AA121098 Hs 3838 NM_O06622 Homo sapiens serum-inducible k 3 12
441283 AA927670 Hs 131704 Hs 131704 ESTs 3 12
418945 BE246762 Hs 89499 NM.000698 Homo sapiens arxhidote 5-lιpo 3 12
418458 AA332941 Hs 85226 NM.000235 Homo sapiens lipase A, lysosom 3 12
408989 AW361666 Hs 49500 Hs 49500 KIAA0746 protein 3 11
436906 H95990 Hs 181244 Hs 181244 major histocompadbility compl 3 11
411089 AA456454 Hs 355702 Hs 355702 ESTs, Weakly simila to AC0048 3 11
432990 AL036071 Hs 279899 NM_003820 Homo sapiens tumor nxrosis fa 3 11
425009 X58288 Hs 154151 NM_002845 Homo sapiens protein tyrosine 310
443601 AI078554 Hs 42658 Hs 42658 Homo sapiens cD FU30167 fis, c 3 10
430603 AA148164 Hs 247280 Hs 247280 chromosome 20 open reading fra 3 10
413672 BE156536 Hs 353632 Hs 353632 ESTs, Moderately simila to hy 309
407786 AA687538 Hs 38972 NM.005727 Homo sapiens tetraspan 1 (TSPA 309
414586 AA306160 Hs 16488 NM.002298 Homo sapiens lymph∞yte cytoso 308
423712 W46802 Hs 81988 Hs 81988 disabled homolog 2, mitogen-res 308
438552 AJ245820 Hs 6314 NM.012410 Homo sapiens type I transmembr 306
448364 T08958 Hs 297214 Hs 297214 HSPC141 protein 306
426437 BE076537 Hs 169895 NM.004223 Homo sapiens ubiquidn-conjuga 306
437679 NM 014214 Hs 5753 NM.014214 Homo sapiens ιnosιtol(myo)-1(o 306
422262 AL022315 Hs 113987 NM.006498 Homo sapiens Ixdn, galxtosi 306
410480 R97457 Hs 63984 NM.001257 Homo sapiens cadhenn 13, H-ca 305
435818 AA700553 Hs 368614 Hs 368614 ESTs 305
418883 BE387036 Hs 1211 NM.001611 Homo sapiens xid phosphatase 305
453613 F06838 Hs 374476 Hs 374476 ESTs 305
408051 AI623351 Hs 172148 Hs 172148 ESTs 305
432278 AL137506 Hs 274256 Hs 274256 hypothetical protein FU23563 304
407949 W21874 Hs 247057 Hs 247057 ESTs Weakly similar to 210926 304
418090 U57059 Hs 83429 NM.O03810 Homo sapiens tumor nxrosis fa 304
433165 AA578904 Hs 292437 Hs 292437 ESTs 303
425809 AA370362 Hs 57958 Hs 57958 EGF-TM7-latrophιlιn-related pro 303
443884 N20617 Hs 194397 Hs 194397 ESTs, Moderately similar to 22 303
447831 AI433293 Hs 164115 Hs 164115 ESTs 302
413278 BE563085 Hs 833 NM.005101 Homo sapiens iπterferon-sdmul 301
418870 AF147204 Hs 89414 Hs 89414 chemokine (C-X-C modf), rxept 300
456376 AA663904 Hs 89862 Hs 89862 TNFRSF1 A-ass∞iated via death d 300
439738 BE246502 Hs 9598 Hs 9598 sema doman, immunoglobulin doma 300
444416 AW288085 Hs 11156 NM.016494 Homo sapiens hypothedcal prot 300
406656 M16714 Hs 89643 Hs 89643 transketolase (Wernicke-Korsako 300
406826 AW516005 Hs 84298 Hs 84298 CD74 andgen (mvanant polypep 299
418707 U97502 Hs 87497 Hs 87497 butyrophilin subfamily 3, memb 299
421742 AW970004 Hs 107528 NM.016108 Homo sapiens androgen induced 299
406824 AW515961 Hs 84298 Hs 84298 CD74 antigen (mvanant polypep 299
435605 AF151815 Hs 4973 NM_015680 Homo sapiens hypothedcal prot 298
410491 AA465131 Hs 64001 Hs 64001 Homo sapiens clone 25218 mR seq 298
427648 AI376722 Hs 180062 NM_004159 Homo sapiens proteasome (proso 298
411125 AA151647 Hs 68877 NM.000101 Homo sapiens cytochrome b-245, 298
435550 AI224456 Hs 324507 Hs 324507 hypothedcal protein FU20986 298
429373 NM 014694 Hs 200594 NM.014694 Homo sapiens KIAA0605 gene pro 298
445701 AF055581 Hs 13131 NM.005475 Homo sapiens lymph∞yte adapto 297
414649 AI672727 Hs 76753 NM.000118 Homo sapiens endoglm (Osler-R 297
444207 AI565004 Hs 374415 Hs 374415 ESTs 297
423225 AA852604 Hs 125359 NM_006288 Homo sapiens Thy-1 cell surfx 297
407792 AI077715 Hs 39384 NM_014344 Homo sapiens four |θinted box 297
445707 AI248720 Hs 114390 Hs 114390 ESTs 296
452888 AW955454 Hs 30942 NM.004093 Homo sapiens ephnn-B2 (EFNB2) 296
418478 U38945 Hs 1174 Hs 1174 cyclm-dependent kise inhibitor 295
411441 AL042355 Hs 70202 Hs 70202 WD repeat domain 10 295
443426 AF098158 Hs 9329 Hs 9329 chromosome 20 open reading frame 294
450876 AF189062 Hs 285976 Hs 285976 LAG1 longevity assurance homol 294 426359 AA376409 Hs 10862 Hs 10862 Homo sapiens cD FU23313 fis 294
425421 L11669 Hs 157145 NM_001120 Homo sapiens tetrxyclme tran 293
449879 H03573 Hs 287830 Hs 287830 Homo sapiens mR, cD DKFZp434E1 293
454075 R43826 Hs 16313 Hs 16313 Kruppel-like zinc finger protei 293
421595 AB014520 Hs 301685 Hs 301685 KIAA0620 protein 293
457949 W69171 Hs 334814 Hs 334814 hypothetical protein FLJ14868 292
443987 AW163123 Hs 10071 NM_016551 Homo sapiens seven transmembra 292
430259 BE550182 Hs 375142 Hs 375142 RalGEF-like protein 3, mouse h 292
415906 AI751357 Hs 288741 Hs 288741 Homo sapiens cD FU22256 fis, 291
429762 AI346255 Hs 216354 NM_0O6913 Homo sapiens nπg finger prote 291
451527 AF022813 Hs 26518 NM_003271 Homo sapiens transmembrane 4 s 291
425356 BE244879 Hs 155939 NM_005541 Homo sapiens inositol polyphos 291
427080 AW068287 Hs 301175 NM.002872 Homo sapiens ras-related C3 bo 291
426432 AF001601 Hs 169857 NM_000305 Homo sapiens parxxose 2 (PON2 290
431476 BE612705 Hs 256697 Hs 256697 histidine toad nucleotide bin 289
406659 AA663985 Hs 277477 Hs 277477 major histocompadbility compl 289
451144 AW956103 Hs 61712 Hs 61712Homo sapiens cD FU31548 fis, c 289
456362 AW973003 Hs 179909 Hs 179909 nuclea receptor coxdvator 6 288
426440 BE382756 Hs 169902 NM_006516 Homo sapiens solute earner fa 288
456974 M12529 Hs 169401 NM_000041 Homo sapiens apolipoprotein E 288
418174 L20688 Hs 83656 Hs 83656 Rho GDP dissxiadon inhibitor 288
446055 AI815981 Hs 12909 Hs 12909 ucolιpιn 1 288
423184 NM 004428 Hs 1624 NM.004428 Homo sapiens ephπn-A1 (EF1), 2 87
427700 AA262294 Hs 180383 NM_001946 Homo sapiens dual specificity 287
410668 BE379794 Hs 159651 NM_016629 Homo sapiens hypothedcal prot 287
444143 AW747996 Hs 160999 Hs 160999 ESTs, Weakly similar to I78885 2 87
407151 H25836 Hs 301527 Hs 301527 ESTs, Moderately simila to un 286
449349 AI825386 Hs 352579 Hs 352579 Homo sapiens, chromosome 20 op 286
436997 AA741151 Hs 137323 Hs 137323 ESTs 286
446143 BE245342 Hs 306079 NM_013336 Homo sapiens protein transport 286
417355 D13168 Hs 82002 Hs 82002 endothelin rxeptor type B 286
431685 AW296135 Hs 267659 NM_006113 Homo sapiens vav 3 oncogene (V 286
408877 AA479033 Hs 130315 Hs 130315 ESTs 285
429615 AF258627 Hs 211562 NM_005502 Homo sapiens ATP-bindmg casse 2 85
412014 AI620650 Hs 43761 Hs 43761 gapjuncdon protein, alpha 7, 284
436749 AA584890 Hs 5302 NM_006149 Homo sapiens Ixdn, galxtosi 284
419625 U91616 Hs 182885 NM_004556 Homo sapiens nuclea fxtor of 284
439941 AI392640 Hs 18272 Hs 18272 solute earner family 38, membe 284
436496 AA281959 Hs 5210 NM_004877 Homo sapiens glia maturation f 284
422100 AI096988 Hs 111554 NM_005737 Homo sapiens AOP-πbosyladon 283
439730 AF035292 Hs 6654 Hs 6654 KIAA0657 protein 283
447217 BE465754 Hs 17778 NM_003872Homo sapiens neuropilin 2 (NRP 283
428343 AL043021 Hs 12705 Hs 12705 similar to HYPOTHETICAL 43 1 KD 282
440524 R71264 Hs 16798 Hs 16798 Homo sapiens mR, cD DKFZp564024 282
415523 AL042003 Hs 296847 NM.003119 Homo sapiens spasdc paraplegi 281
439668 AI091277 Hs 302634 Hs 302634 fπzzled homolog 8 (Drosophila 281
414570 Y00285 Hs 76473 NM_000876 Homo sapiens insulin-like grow 2 80
426535 AU077012 Hs 288582 NM.006287 Homo sapiens tissue fxtor pat 280
409649 AA159216 Hs 55505 Hs 55505 hypothedcal protein FU20442 280
406655 M21533 Hs 277477 Hs 277477 major histocompadbility compl 279
415323 BE269352 Hs 949 NM.0O0433 Homo sapiens neutrophil cytoso 279
443195 BE148235 Hs 193063 Hs 193063 Homo sapiens cD FU14201 fis, 2 78
451356 AA748418 Hs 164577 Hs 164577 ESTs 278
450708 AA376654 Hs 350065 Hs 350065 Homo sapiens cD FU30634 fis 2 78
433681 AI004377 Hs 200360 Hs 200360 Homo sapiens cD FU 13027 fis, 277
442599 AF078037 Hs 324051 NM_006663 Homo sapiens RelA-associated i 276
414509 AW161311 Hs 76294 NM_001780 Homo sapiens CD63 andgen (mei 276
431394 AK000692 Hs 252351 Hs 252351 HERV-H LTR-associadng 2 276
417331 AW411297 Hs 81972 Hs 81972 SHC (Src homology 2 domain cont 2 76
415995 NM 004573 Hs 355888 NM_0O4573 Homo sapiens phospholipase C, 275
414911 NM 000107 Hs 77602 NM.000107 Homo sapiens damage-spxific D 2 75
425976 C75094 Hs 334514 Hs 334514 chromosome 6 open reading fram 275
407893 BE408359 Hs 43621 Hs 43621 hypothedcal protein MBC3205 275
407903 AI287341 Hs 154029 Hs 154029 bHLH fxtor Hes4 2 75
416062 AA724811 Hs 334791 Hs 334791 simila to neurol tetraspanin 2 75
428494 AA233439 Hs 184634 Hs 184634 hypothetical protein FLJ20005 2 75
421506 BE302796 Hs 105097 NM.003258 Homo sapiens thymidine kise 1. 274
427581 NM 014788 Hs 179703 NM.014788 Homo sapiens tnpartite modf- 2 74
424527 AW138558 Hs 334873 Hs 334873 carboxypepddase M 2 74
439578 AW263124 Hs 350547 Hs 350547 nuclea receptor co-repressor/ 2 74
425188 AK002052 Hs 155071 Hs 155071 chromosome 20 open reading fra 274
428013 AF151020 Hs 181444 NM.016456 Homo sapiens hypothetical prot 2 73
439333 AW384710 Hs 132986 Hs 132986 Homo sapiens cD FU31588 fis, 273
450935 BE514743 Hs 355753 NM_005851 Homo sapiens tumor suppressor 2 73
421532 AW138207 Hs 146170 Hs 146170 hypothetical protein FU22969 2 73
440502 AI824113 Hs 78281 Hs 78281 regulator of G-protem siglling 2 73
444981 AW855398 Hs 12210 Hs 12210 tumor endothelial marker 6 2 72
439219 N33883 Hs 41322 Hs 41322 ESTs 2 72
416847 L43821 Hs 80261 NM_006403 Homo sapiens enhancer of filam 2 72
433179 AW362945 Hs 162459 Hs 162459 ESTs 2 72
424528 AW073971 Hs 238954 Hs 238954 ESTs, Weakly similar to putati 2 71
411213 AA676939 Hs 69285 NM_0 3873 Homo sapiens neuropilin 1 (NRP 2 70
433012 NM 004045 i Hs 279910 NM_004045.Ho.no sapiens ATX1 andoxidant 270 425345 AU077297 Hs 155894 NM.002827 Homo sapiens protein tyrosine 269
428923 BE047698 Hs 188785 Hs 188785 ESTs 269
427923 AW274357 Hs 301406 Hs 301406 hypothetical protein PP3501 269
446644 NM.003272 Hs 15791 NM.003272 Homo sapiens transmembrane 7 s 269
421743 T35958 Hs 107614 Hs 107614 DKFZP564I1171 protein 268
416207 NM.014745 Hs 79077 NM.014745 Homo sapiens KIAA0233 gene pro 268
420372 AW960049 Hs 293660 Hs 293660 gene overexpressed in astrocyt 268
420542 NM 000505 Hs 1321 NM.000505 Homo sapiens coaguladon fxto 267
425069 AA687465 Hs 298184 Hs 298184 potassium voltage-gated channe 267
418558 AW082266 Hs 86131 NM.0O3824 Homo sapiens Fas (TNFRSF6)-ass 267
426251 M24283 Hs 168383 NM_000201 Homo sapiens intercellular adh 266
406701 AA780613 Hs 62954 Hs 62954 femdn, heavy polypepdde 1 266
431681 AK0O0378 Hs 267566 Hs 267566 hypothedcal protein FU20371 266
412833 AW960547 Hs 298262 Hs 298262 πbosomal protein S19 266
433101 AW572317 Hs 12082 HS 12082 TIGA1 266
414774 X02419 Hs 77274 NM_002658 Homo sapiens plasminogen xdv 266
427868 AI360119 Hs 181013 NM_002629 Homo sapiens phosphoglycerate 266
413929 BE501689 Hs 75617 Hs 75617 collagen, type IV, alpha 2 266
424762 AU 19442 Hs 183684 Hs 183684 eukaryodc transladon imdat 266
422048 NM_012445 Hs 288126 NM.012445 Homo sapiens spondin 2, extrx 265
431350 AI192528 Hs 164537 Hs 164537 ESTs 265
450184 W31096 Hs 237617 Hs 237617 dipepddylpepddase 9 265
419285 D31887 Hs 89868 Hs 89868 KIAA0062 protein 265
414217 AI309298 Hs 279898 Hs 279898 Homo sapiens CD FU23165fis, 264
451253 H48299 Hs 26126 NM.006984 Homo sapiens claudin 10 (CLDN1 264
435905 AW997484 Hs 5003 Hs 5003 SLIT-ROBO Rho GTPase-xdvadng 264
432581 AU076465 Hs 278441 NM_014634 Homo sapiens KIAA0015 gene pro 263
415782 AA169345 Hs 123177 Hs 123177 hypothedcal protein BC011406 263
430223 NM 002514 Hs 235935 NM.002514 Homo sapiens nephroblastoma ov 263
417526 AA568906 Hs 82240 NM.004177 Homo sapiens syntaxin 3A (STX3 263
409956 AW103364 Hs 727 NM_002192 Homo sapiens inhibin, beta A ( 263
449843 R85337 Hs 24030 NM_001860 Homo sapiens solute earner fa 262
417389 BE260964 Hs 82045 NM_O02391 Homo sapiens midkme (neunte 262
446312 BE087853 Hs 171802 Hs 171802 Homo sapiens, clone IMAGE 3956 262
435099 AC004770 Hs 4756 Hs 4756 flap structure-spxific eπdoπucl 262
417920 S47833 Hs 82927 NM_004037 Homo sapiens adenosine monopho 262
435702 AI033647 Hs 121001 Hs 121001 Homo sapiens, clone MGC 45521 262
422959 AV647015 Hs 349256 Hs 349256 paired immunoglobulin-like rx 262
419938 AU076772 Hs 1279 NM_001733 Homo sapiens complement compoπ 262
450954 AI904740 Hs 25691 NM_005856 Homo sapiens receptor (calcito 261
421753 BE314828 Hs 107911 Hs 107911 ATP-bindmg cassette, sub-fami 261
443577 AI078033 Hs 177170 Hs 177170 ESTs, Weakly similar to ALU8_H 261
453886 R66282 Hs 20247 Hs 20247 ESTs 261
421883 X55079 Hs 1437 NM_000152 Homo sapiens glucosidase, alph 260
440457 BE387593 Hs 21321 Hs 21321 granule cell differentiation pr 260
410295 AA741357 Hs 356624 Hs 356624 ESTs 259
420679 X57152 Hs 99853 NM_001436 Homo sapiens fibπllann (FBL) 259
451558 NM 001089 Hs 26630 NMJ01089 Homo sapiens ATP-bmding casse 259
444672 Z95636 Hs 11669 Hs 11669 laminin, alpha 5 259
408669 AI493591 Hs 78146 Hs 78146 platelet/endothelial cell adhes 259
426194 T50872 Hs 2001 Hs 2001 thromboxane A synthase 1 (platel 259
421814 L12350 Hs 108623 NM_003247 Homo sapiens thrombospondin 2 259
456371 S76825 Hs 89695 Hs 89695 insulin rxeptor 259
429098 AF030249 Hs 196176 NM_001398 Homo sapiens enoyl Coenzyme A 259
414443 AU077268 Hs 76144 NM_002609 Homo sapiens platelet derived 259
428484 AF104032 Hs 184601 NM.003486 Homo sapiens solute earner fa 259
453309 AI791809 Hs 32949 NM.005218 Homo sapiens defensin beta l 259
412867 AU076861 Hs 74637 NM_003217 Homo sapiens tesds enhanced g 258
432827 Z68128 Hs 3109 Hs 3109 Rho GTPase xdvadng protein 4 258
412669 AW880841 Hs 96908 NM_006034 Homo sapiens p53-ιnduced prote 258
412115 AK001763 Hs 73239 Hs 73239 hypothetical protein FU10901 258
452866 R26969 Hs 268016 Hs 268016 Homo sapiens cD FLJ21243 fis, 258
435129 AI381659 Hs 267086 Hs 267086 ESTs 257
424482 BE268621 Hs 149155 NM_003374 Homo sapiens voltage-dependent 257
410494 M36564 Hs 64016 NM.000313 Homo sapiens protein S (alpha) 256
433895 AI287912 Hs 3628 NM_004834 Homo sapiens mitogen-xdvated 256
442566 R37337 Hs 12111 Hs 12111 ESTs 256
417640 D30857 Hs 82353 NM_006404 Homo sapiens protein C recepto 256
442622 NM_000435 Hs 8546 NM_000435 Homo sapiens Notch homolog 3 ( 256
430346 AK000331 Hs 297641 Hs 297641 rednoblastoma-ass∞iated fxt 255
419344 U94905 Hs 277445 Hs 277445 diacylglycerol kise, zeta (104 255
426500 NM.014638 Hs 170156 NM.01 638 Homo sapiens KIAA0450 gene pro 255
408048 NM 007203 Hs 42322 NM.007203 Homo sapiens A kise (PRKA) anc 255
450700 AW732799 Hs 25348 NM.005860 Homo sapiens follistadn-like 254
417018 M16038 Hs 80887 NM.002350 Homo sapiens v-yes-1 Yamaguchi 254
419378 R24922 Hs 90078 Hs 90078 nucleodde-suga transporter si 254
422451 AA310753 Hs 42491 Hs 42491 ESTs. Moderately similar to hyp 253
435906 AI686379 Hs 110796 Hs 110796 SAR1 protein 253
400231 253
417849 AW291587 Hs 82733 NM_007361 Homo sapiens nidogen 2 (NID2), 253
427380 NM 005534 Hs 177559 NM.0 5534 Homo sapiens interferon gamma 252
428385 AF112213 Hs 184062 Hs 184062 chromosome 20 open reading fra 252
438000 AI825880 Hs 5985 Hs 5985 non-kise Cdc42 effector protein 252 448719 AA033627 Hs 21858 Hs 21858 senne (or cysteine) proteise i 252
422396 W21872 Hs 7907 Hs 7907 L-fucose kise 252
420787 AA564248 Hs 351292 Hs 351292-Homo sapiens cD FU32605 fis, 251
430590 AW383947 Hs 246381 NM.001251 Homo sapiens CD68 andgen (CD6 251
447026 BE313144 Hs 324844 Hs 324844 hypothetical protein IMAGE3455 2 51
439223 AW238299 Hs 250618 Hs 250618 UL16 binding protein 2 250
435151 AA348482 Hs4788 Hs 4788 nicastπn 2 50
448202 AB002292 Hs 20695 NM_014629 Homo sapiens Rho guanine nude 250
449943 AF104266 Hs 24212 Hs 24212 latrophilin 250
425743 BE396495 Hs 159428 Hs 159428 BCL2-assocιated X protein 2 50
444681 AJ243937 Hs 288316 Hs 288316 chromosome 6 open reading fram 250
421643 BE281170 Hs 106357 NM_007126 Homo sapiens valosin-containin 250
426865 D63476 Hs 172813 NM_003899 Homo sapiens Rho guanine nude 250
432306 Y18207 Hs 303090 NM_0O5398 Homo sapiens protein phosphate 249
421846 AA017707 Hs1432 NM_002743 Homo sapiens protein kise C su 249
421905 AI660247 Hs 32699 Hs 32699 Homo sapiens, Similar to RIKEN 249
419493 AF001212 Hs 90744 NM.0O2815 Homo sapiens proteasome (proso 249
422530 AW972300 Hs 118110 NM_004335 Homo sapiens bone marrow strom 248
442821 BE391929 Hs 8752 NM_014255 Homo sapiens transmembrane pro 248
416919 T97839 Hs 80464 NM_006402 Homo sapiens hepadds B virus 248
443105 X96753 Hs9004 NM.001897 Homo sapiens chondroidn sulfa 248
430040 AW503115 Hs 227823 NM_014287 Homo sapiens pM5 protein (PM5) 248
428028 U52112 Hs 182018 NM_0O1569 Homo sapiens interieukin- 1 rx 247
424307 AW293399 Hs356377 Hs 356377 Homo sapiens, clone IMAGE 3633 246
434511 R28982 Hs 18106 Hs 18106 ESTs, Weakly similar to T06291 246
454390 AB020713 Hs56966 Hs 56966 KIAA0906 protein 246
417785 X59812 Hs82568 NM.000784 Homo sapiens cytxhrome P450, 246
424673 AA345051 Hs 294092 Hs 294092 Homo sapiens mR full length in 246
422003 AA361760 Hs 296326 Hs 296326 ESTs, Weakly similar to A33533 246
432126 AA865239 Hs 37196 Hs 37196 putative G protein coupled rxe 246
445937 AI452943 Hs 321231 NM.003779 Homo sapiens UDP-Gal betaGlcc 246
409354 N68188 Hs 159472 Hs 159472 Homo sapiens cD FU22224 fis, 246
401179 246
418151 AA864238 Hs 83583 NM_005731 Homo sapiens xdn related pro 245
422648 D86983 Hs 118893 Hs 118893 Melanoma associated gene 245
427759 BE245578 Hs220O NM_O05041 Homo sapiens perfoπn 1 (prefo 245
431222 X56777 Hs 273790 NM.00 155 Homo sapiens zo pellucida glyc 245
411529 AA430348 Hs 317596 Hs 317596 Homo sapiens cD FU12927 fis, 2 45
426825 AL133415 Hs 297753 NM.003380 Homo sapiens vimendn (VIM), m 245
422242 AJ251760 Hs 273385 NM 016592 Homo sapiens GS complex Ixus 245
408105 AW152207 Hs 270977 Hs 270977 ESTs 244
426410 BE298446 Hs 305890 Hs 305890 BCL2-lιke 1 244
421064 AI245432 Hs 101382 NM_006291 Homo sapiens tumor nxrosis fa 244
428157 AI738719 Hs 198427 NM_000189 Homo sapiens hexokise 2 (HK2) 244
424398 BE397787 Hs 146393 NM_014685 Homo sapiens homxysteine-indu 2 44
424825 AF207069 Hs 153357 NM.001084 Homo sapiens procollagen-lysin 244
426031 AA295251 Hs 166066 Hs 166066 cisplatin resistance associate 243
409817 BE295464 Hs 56607 Hs 56607 Willia s-Beuren syndrome chroπvo 243
429359 W0O482 Hs 2399 NM_004995 Homo sapiens matπx metallopro 243
426761 AI015709 Hs 172089 Hs 172089 pro-oncosis rxeptor inducing 243
429332 AF030403 Hs 199263 NM_013233 Homo sapiens senne threonine 243
425923 NM 005026 Hs 162808 NM_O05026 Homo sapiens phosphomositide- 243
432211 BE274530 Hs 273333 Hs 273333 hypothedcal protein FU10986 243
433339 AF019226 Hs 8036 Hs 8036 RAB3D, member RAS oncogene famil 2 42
420539 AA282735 Hs 44004 Hs 44004 AD031 protein 242
413243 AA769266 Hs 193657 Hs 193657 ESTs 242
435029 AF167706 Hs 19280 Hs 19280 cyste e-nch motor neuron 1 242
422374 AW732869 Hs 1519 Hs 1519 protein kise, cAMP-dependent, re 242
444501 AW247624 Hs 11342 NM 004148 Homo sapiens πmjuπn 1 (NINJ1 242
414919 AW087337 Hs 194461 Hs Ϊ94461 ESTs 242
419355 AA428520 Hs90061 NM_006667 Homo sapiens progesterone rece 242
436042 AF284422 Hs 119178 Hs 119178 cadon-chlonde cotransporter- 242
418245 AA088767 Hs 83883 Hs 83883 transmembrane, prostate androge 242
444215 AB033075 Hs 10669 Hs 10669 development and differentiation 241
408683 R58665 Hs 46847 NMJ16614 Homo sapiens TRAF and TNF rxe 241
423701 AA329856 Hs 143022 Hs 143022 ESTs 241
441783 BE313412 Hs 7961 Hs 7961 Homo sapiens clone 25012 mR sequ 2 41
428072 BE258602 Hs 182366 NM.016292 Homo sapiens heat shxk protei 241
434599 AB002313 Hs 3989 Hs 3989 plexm B2 240
442351 W52642 Hs8261 Hs 8261 SPRY doman-contanmg SOCS box 240
407894 AJ278313 Hs41143 Hs 41143 phospholipase C. beta 1 (phosph 240
453449 W16752 Hs 32981 Hs 32981 sema doman, immunoglobulin dom 240
408688 AI634522 Hs 152925 Hs 152925 KIAA1268 protein 240
422448 AW372922 Hs 116774 Hs 116774 integnn, alpha 1 239
416269 AA177138 Hs 161671 Hs 161671 ESTs 239
452679 Z42387 Hs 83883 Hs 83883 transmembrane. prostate androge 238
432981 NM 002733 Hs3136 NM_002733 Homo sapiens protein kise. AMP 238
419846 NM 015977 Hs 285681 Hs 285681 Williams Beuren syndrome chrom 2 38
422110 AI376736 Hs 111779 Hs 111779 sxreted protein xidic, cyst 238
413092 AA126856 Hs 118665 Hs 118665 ESTs 2 38
433969 AW207279 Hs 271786 Hs 271786 ESTs Weakly simila to PC4395 237
451267 AI033894 Hs 117865 Hs 117865 solute earner family 17 (aπio 2 37
447526 AL048753 Hs 303649 NM_002982 Homo sapiens small inducible c 237 441623 AA315805 Hs 348710 Hs 348710 Homo sapiens, ctone IMAGE 4242 237
420255 NM 007289 Hs 1298 NM_007289 Homo sapiens membrane metallo- 237
409274 NM 003930 Hs 52644 NM.003930 Homo sapiens src family ass∞i 236
422801 AF125672 Hs 287994 Hs 287994 nuclear rxeptor co-repressor 236
407887 AA579668 Hs 41072 Hs 41072 serine (or cysteine) proteise i 236
408212 AA297567 Hs 43728 NM_015696 Homo sapiens weakly similar to 236
430478 NM.014349 Hs 241535 NM_014349 Homo sapiens apolipoprotein L, 236
405102 235
423583 AL122055 Hs 129836 Hs 129836 KIAA1028 protein 235
426125 X87241 Hs 166994 NM_005245 Homo sapiens FAT tumor suppres 235
425204 NM 002436 Hs 1861 NMJ02436 Homo sapiens membrane protein, 235
420676 AI434780 Hs 4248 Hs 4248 Homo sapiens PP3781 mR, complete 235
421079 AW404994 Hs 101695 Hs 101695 NCK adaptor protein 2 235
410039 AF207989 Hs 58014 Hs 58014 G protein-coupled rxeptor, fam 234
412958 BE391579 Hs 75087 NM.006712 Homo sapiens FAST kise (FASTK) 234
430363 M28713 Hs 274464 NM_000398 Homo sapiens diaphorase (DH) ( 234
425397 J04088 Hs 156346 NM_001067 Homo sapiens topoisomerase (D) 234
451035 AU076785 Hs 430 NM_002670 Homo sapiens plasdn 1 (I isof 234
449027 AJ271216 Hs 22880 Hs 22880 dipepddylpepddase III 234
429457 BE243065 Hs 202955 Hs 202955 hypothedcal protein FLJ20507 234
417709 D87434 Hs 82426 NM_014734 Homo sapiens KIAA0247 gene pro 234
412805 AW954569 Hs 278675 Hs 278675 bromodoman-containing 4 234
427647 W19744 Hs 180059 Hs 180059 Homo sapiens cD FU31360 fis, 234
430702 U56979 Hs 278568 NM_000186 Homo sapiens H fxtor 1 (compl 233
456804 AI421645 Hs 139851 NM_001233 Homo sapiens caveolm 2 (CAV2) 233
453648 W21493 Hs 28329 Hs 28329 protein phosphatase 1, regulate 233
450812 AB002360 Hs 25515 Hs 25515 MCF 2 cell line denved transfo 233
402575 233
424670 W61215 Hs 116651 NM_005797 Homo sapiens epithelial V-like 232
452960 AK001335 Hs 31137 NM_006504 Homo sapiens protein tyrosine 232
442968 AK000606 Hs 8868 NM.004871 Homo sapiens golgi SP rxeptor 232
410639 BE269047 Hs 65234 Hs 65234 DEAD/H (Asp-Glu-Ala-Asp/His) bo 232
415169 W42913 Hs 78089 NM_004231 Homo sapiens ATPase, H+ transp 232
450160 BE048099 Hs 183738 Hs 183738 FERM, RhoGEF (ARHGEF) and plx 232
407223 H96850 H96850 yw03b12 s1 Soares melan∞yte 2NbH 232
426780 BE242284 Hs 172199 NM 001114 Homo sapiens adenylate cyclase 232
434987 AW975114 Hs 371677 Hs 371677 ESTs 232
416354 NM 000633 Hs 79241 NM.000633 Homo sapiens B-cell CLL/lympho 231
453107 NM 016113 Hs 279746 NM.016113 Homo sapiens transient rxepto 231
422963 M79141 Hs 13234 Hs Ϊ3234 ESTs, Weakly simila to hypothe 231
433618 AA602539 Hs 345494 Hs 345494 ESTs, Moderately similar to ZN 231
438584 AA811347 AA811347 ob81h06 s1 NCI.CGAP.GCB1 Homo s 231
446126 AW085909 Hs 356618 Hs 356618 ESTs, Weakly similar to PC4259 231
408716 AI567839 Hs 151714 Hs 151714 peroxisomal proliferator-xdv 230
433230 AW136134 Hs 220277 Hs 220277 ESTs, Weakly similar to expres 230
410168 AW834050 Hs 351432 Hs 351432 tensm 230
446342 BE298665 Hs 14846 Hs 14846 Homo sapiens mR, cD DKFZp564D01 230
418452 BE379749 Hs 85201 NMJW5127 Homo sapiens C-type (calcium d 230
453175 NM.006834 Hs 32217 NM.006834 Homo sapiens RAB32, member RAS 229
409012 AL117435 Hs 49725 Hs 49725 DKFZP434I216 protein 229
452848 AI417193 Hs 288912 Hs 288912 BBP-like protein 2 229
418838 AW385224 Hs 35198 Hs 35198 xtonucl∞dde pyrophosphatase/ 229
422562 AI962060 Hs 118397 NM.001129 Homo sapiens AE binding protei 228
432828 AB042326 Hs 287402 Hs 287402 chondroidn 4-sulfotransferase 228
412948 BE243313 Hs 334851 NM_006148 Homo sapiens LIM and SH3 prote 228
426068 AF029778 Hs 166154 NM_002226 Homo sapiens lagged 2 (JAG2), 228
456919 NM 003900 Hs 182248 NM_003900 Homo sapiens sequestosome 1 (S 228
452806 AW014549 Hs 58373 Hs 58373 ESTs 228
453983 H94997 Hs 16450 Hs 16450 ESTs 228
407736 N41744 Hs 349326 Hs 349326 Homo sapiens cD FLJ30677 fis. 228
413211 AW967107 Hs 109274 Hs 109274 hypothetical protein MGC4365 228
422051 AW327546 Hs 111024 Hs 111024 solute earner family 25 (mito 227
438438 AA257992 Hs 50651 Hs 50651 Janus kise 1 (a protein tyrosin 227
436278 BE396290 Hs 5097 NM_004710 Homo sapiens syptogyπn 2 (SYN 227
454080 AI199711 Hs 576 NM_0001 7 Homo sapiens fucosidase, alpha 227
426542 AF190746 Hs 170310 NM_017424 Homo sapiens cat eye syndrome 227
417115 AW952792 Hs 334612 NM_003094 Homo sapiens small nuclear nb 227
402901 226
412898 AI129903 Hs 74669 NM_006634 Homo sapiens vesicle-ass∞iate 226
413020 R98736 R98736 yr31h09 r1 Soares fetal liver spl 226
413939 AL047051 Hs 199961 Hs 199961 ESTs, Weakly similar to hypoth 226
408681 AW953853 Hs 281462 Hs 281462 hypothetical protein FLJ14251 225
412330 NM 005100 Hs 788 NM_005100 Homo sapiens A kise (PRKA) anc 225
442083 R50192 Hs 165062 Hs 165062 ESTs 225
418271 NM 000919 Hs 83920 NM.000919 Homo sapiens pepddylglycine a 225
433376 AI249361 Hs 74122 NM_001225 Homo sapiens caspase 4, apopto 225
438562 AI566826 Hs 25890 Hs 25890 ESTs, Weakly similar to transdu 225
443883 AA114212 Hs 9930 NM_0O1235 Homo sapiens serine (or cystei 225
416976 BE243985 Hs 80680 Hs 80680 major vault protein 224
416914 AA344481 Hs 80426 Hs 80426 bran and reproductive organ-ex 224
400288 X06256 Hs 149609 NM.0 2205 Homo sapiens integnn alpha 5 224
407904 W44735 Hs 107260 Hs 107260 putative UDP-Galc polypepdde 224
429690 AW956329 Hs 23721 Hs 23721 ESTs 224 443813 AA876372 Hs 93961 Hs 93961 Homo sapiens mR, cD DKFZp667D09 224
427458 BE208364 Hs 29283 Hs 29283 ESTs, Weakly similar to LKHU pr 224
454294 AB000734 Hs 50640 NM_003745 Homo sapiens JAK binding prote 224
407192 AA609200 Hs 366318 Hs 366318 ESTs 223
425751 T19239 Hs 1940 NM_0 1885 Homo sapiens ciystallm, alpha 2 23
456437 AI924228 Hs 115185 Hs 115185 ESTs 223
413019 BE281604 Hs 75140 NM_002337 Homo sapiens low density lipop 2 23
418862 BE550964 Hs 89399 Hs 89399 ATP synthase, H+ transporting, 223
435284 AA879470 Hs 96849 Hs 96849 Homo sapiens cD FU11492 fis, c 223
429630 M85289 Hs 211573 NM_005529 Homo sapiens heparan sulfate p 223
427609 AK000436 Hs 179791 Hs 179791 RAB20, member RAS oncogene fam 223
421917 AB028943 Hs 109445 Hs 109445 hypermethylated in cancer 2 223
446616 R65964 Hs 334873 Hs 334873 carboxypepddase M 223
407232 X04526 X04526 Human liver R for beta-subunit s 223
423798 AF047033 Hs 132904 Hs 132904 solute earner family 4, sodiu 223
446755 AW451473 Hs 16134 NM_005990 Homo sapiens seπne/threonme 222
452865 AI924046 Hs 119567 Hs 119567 ESTs, Weakly similar to ALU1_H 222
431393 AW971493 Hs 134269 Hs 134269 ESTs, Weakly simila to 200439 222
431890 X17033 Hs 271986 NM_002203 Homo sapiens integnn, alpha 2 2 22
428782 X12830 Hs 193400 NM_000565.Homo sapiens interieukin 6 rx 222
446006 NM 004403 Hs 13530 NMJ304403 Homo sapiens deafness, autosom 222
436418 AJ245874 Hs 4245 Hs 4245 chromosome 11 hypothetical prote 222
423869 BE409301 Hs 134012 NM_006688 Homo sapiens C1q-related fxto 221
437730 AW071087 Hs 239176 Hs 239176 insulin-like growth fxtor 1 r 221
444020 R92962 Hs 35052 Hs 35052 ESTs 2 21
413882 AA132973 Hs 184492 Hs 184492Homo sapiens mR, cD DKFZp667B0 221
412654 AI093480 Hs 374319 Hs 374319 ESTs 221
448988 Y09763 Hs 22785 NM_004961 Homo sapiens gamma-ammobutyπ 221
426841 AI052358 Hs 131741 Hs 131741 ESTs 221
408196 AL034548 Hs 43627 NM.006943 Homo sapiens SRY (sex determm 2 21
451711 AK000461 Hs 26890 Hs 26890 cat eye syndrome chromosome reg 220
414325 AA251929 Hs 355341 Hs 355341 Homo sapiens, ctone IMAGE 3536 220
424512 X53002 Hs 149846 NM_002213 Homo sapiens integnn, beta 5 2 20
448883 BE614989 Hs 7503 Hs 7503 hypothedcal protein FU14153 220
411296 BE207307 Hs 10114 Hs 10114 growth suppressor 1 220
452268 NM 003512 Hs 28777 NM_003512 Homo sapiens H2A histone famil 220
416810 AF035606 Hs 80019 NM.013232 Homo sapiens programmed cell d 220
441415 H21497 Hs 7471 Hs 7471 BBP-like protein 1 220
444212 AW503976 Hs 10649 NM.004848 Homo sapiens basement membrane 2 19
428044 AA093322 Hs 301404 NMJW6743 Homo sapiens R binding motif p 2 19
430017 AA263172 Hs 35 NM_002832 Homo sapiens protein tyrosine 2 19
424490 AJ278016 Hs 55565 Hs 55565 ankyπn repeat domain 3 2 19
431193 AW749505 Hs 296770 Hs 296770 KIAA1719 protein 2 19
453686 AL110326 Hs 304679 Hs 304679 ESTs, Weakly simila to Z195_H 2 19
448262 AW880830 Hs 186273 Hs 186273 ESTs 2 19
416065 BE267931 Hs 78996 NM_002592 Homo sapiens proliferating cel 2 19
442045 C05768 Hs 8078 Hs 8078 Homo sapiens clone FBD3 Cπ-du-c 2 19
423804 AW403448 Hs 1706 NM.0 6084 Homo sapiens interferon-sdmul 2 19
428024 Z29067 Hs 2236 Hs 2236 NIMA (never in mitosis gene a)-r 2 19
424503 NM 002205 Hs 149609 NM.002205 Homo sapiens integnn, alpha 5 2 19
437696 Z83844 Hs 5790 Hs 5790 hypothedcal protein dJ37E165 2 18
405204 2 18
426158 NM 001982 Hs 199067 NM.001982 Homo sapiens v-erb-b2 erythrob 218
417418 NM 002468 Hs 82116 NM.002468 Homo sapiens myeloid different 2 18
412773 H15785 Hs 74573 NM.012268 Homo sapiens similar to vaxm 2 18
409402 AF208234 Hs 695 NM_0O0100 Homo sapiens cystatin B (stefi 2 18
443791 N64458 Hs 143345 Hs 143345 ESTs 2 18
435049 AL122067 Hs 4746 Hs 4746 hypothedcal protein FU21324 2 18
418389 AA830613 Hs 293849 Hs 293849 ESTs 2 18
450712 AI732130 Hs 270496 Hs 270496 ESTs, Weakly similar to ALUB_H 2 18
422007 AI739435 Hs 39168 Hs 39168 ESTs, Weakly similar to T17340 2 18
453676 AW853745 Hs 286035 Hs 286035 hypothetical protein FU22686 2 18
415718 F30631 Hs 200237 Hs 200237 ESTs 2 18
452688 AA721140 Hs 49930 Hs 49930 ESTs, Weakly similar to B34087 2 18
415988 BE407713 Hs 78943 NM_000386 Homo sapiens bleomycin hydrola 2 18
409453 AI885516 Hs 95612 Hs 95612 ESTs 2 17
417512 X76534 Hs 82226 NM_002510 Homo sapiens glycoprotein (tra 2 17
427202 BE272922 Hs 173936 NM_O00628 Homo sapiens interieukin 10 re 2 17
440983 M20681 Hs 7594 NM.006931 Homo sapiens solute earner fa 2 17
416084 L16991 Hs 79006 NM_012145 Homo sapiens deoxythymidylate 2 17
429642 X68264 Hs 211579 NM_006500 Homo sapiens melanoma adhesion 2 17
427213 AW007211 Hs 348389 Hs 348389 hypothedcal protein FU12876 2 17
437763 AA469369 Hs 5831 NM.003254 Homo sapiens dssue inhibitor 2 17
454000 AA040620 Hs 5672 Hs 5672 golgi membrane protein SB 140 2 17
424247 X14008 Hs 234734 NM_O00239 Homo sapiens lysozyme (rel amy 2 16
403857 2 16
406648 AA563730 Hs 277477 Hs 277477 ma|or histxompadbility compl 2 16
400265 2 16
442379 NM 004613 Hs 8265 NM_004613 Homo sapiens transglutamise 2 2 16
441892 AB028981 Hs 8021 Hs 8021 KIAA1058 protein 2 16
417446 AL118671 Hs 82163 NM.000898 Homo sapiens monoamine oxidase 2 16
418386 AA361739 Hs 84549 NM.002494 Homo sapiens DH dehydrogese (u 2 16
414053 BE391635 Hs 75725 NM_003564 Homo sapiens fransgelin 2 (TAG 2 16 440906 AW161556 Hs 240170 Hs 240170 hypothetical protein MGC2731 2 16
447660 AW160386 Hs 163667 Hs 163667 ESTs, Weakly simila to CA1H_H 2 16
408279 AF216965 Hs 44095 Hs 44095 cyclιn M3 2 16
426152 BE299190 Hs 167246 Hs 167246 P450 (cytochrome) oxidoreducta 2 16
437952 D63209 Hs 5944 NM_014585 Homo sapiens solute earner fa 2 16
415661 AF057307 Hs 78575 Hs 78575 prosaposm (vanant Gaucher dis 2 15
425302 U79115 Hs 155566 NM 003805 Homo sapiens CASP2 and RIPK1 d 2 15
425996 W67330 Hs 374451 Hs 374451 ESTs 2 15
413745 AW247252 Hs 75514 NM_O00270 Homo sapiens nucleoside phosph 2 15
422070 AF149785 Hs 111126 Hs 111126 pituitary tumor-transforming 1 2 15
448424 AW009892 Hs 31924 Hs 31924 ESTs 2 15
430035 NM.003463 Hs 227777 NM_003463 Homo sapiens protein tyrosine 2 15
438407 AI457122 Hs 129673 Hs 129673 eukaryodc transladon initiat 2 15
435551 AF212365 HS 5470 Hs 5470 interieukin 17B receptor 2 15
437741 BE561610 Hs 5809 Hs 5809 putadve transmembrane protem, 2 15
441192 AA526626 Hs 7736 NM.016504 Homo sapiens mit∞hondnal nb 2 15
435750 AB029012 Hs 4990 Hs 4990 KIAA1089 protein 2 15
411165 NM 000169 Hs 69089 NM.000169 Homo sapiens galxtosidase, al 2 14
425252 AW391162 Hs 349306 Hs 349306 hypothedcal protein FU31951 2 14
427600 AW630918 Hs 179774 NM.002818 Homo sapiens proteasome (proso 2 14
426818 AA554827 Hs 292996 Hs 292996 postmeiodc segregation increa 2 14
442110 AF113008 Hs 8102 NM.001023 Homo sapiens πbosomal protein 2 14
407797 AK000524 Hs 39850 Hs 39850 undine kise-like 1 2 14
443044 N28522 Hs 8935 NM 014298 Homo sapiens quinolite phospho 2 14
437103 AW139408 Hs 152940 Hs Ϊ52940 ESTs 2 14
442069 AW664144 Hs 297007 Hs 297007 Homo sapiens cD FU32174 fis, 2 14
424954 NM 000546 Hs 1846 NM.000546 Homo sapiens tumor protein p53 214
458097 AW341135 Hs 58104 Hs 58104 Homo sapiens, clone IMAGE 47309 2 14
411925 AW014588 Hs 72925 NM.O03475 Homo sapiens chromosome 11 ope 2 14
449644 AW960707 Hs 148324 Hs 148324 ESTs 2 14
422675 BE018517 Hs 119140 NM.001970 Homo sapiens eukaryodc fransl 2 14
428586 M36712 Hs 2299 Hs 2299 CD8 andgen, beta polypeptide 1 2 14
429379 NM 014840 Hs 200598 NM.014840 Homo sapiens KIAA0537 gene pro 2 13
410290 AA402307 Hs 322844 Hs 322844 hypothedcal protein OKFZp564A 2 13
443895 AW979048 Hs 292565 Hs 292566 YEA4 protein 2 13
428145 BE243327 Hs 182626 NM.012264 Homo sapiens chromosome 22 ope 2 13
453518 AW503205 Hs 27268 Hs 27268 Homo sapiens cD FU21933fis, 2 13
456534 X91195 Hs 100623 Hs 100623 protein phosphatase 1, regulat 2 13
419972 AL041465 Hs 182982 Hs 182982golgιn-67 2 13
424950 AA602917 Hs 156974 Hs 156974 ESTs 2 13
427557 NM 002659 Hs 179657 NM.002659 Homo sapiens plasminogeπ xtiv 2 13
431449 M55994 Hs 256278 NM_ 01066 Homo sapiens tumor nxrosis fa 2 13
418758 AW959311 Hs 172012 Hs 172012 hypothetical protein DKFZp434J 2 13
434202 BE382411 Hs 3764 NM.000858 Homo sapiens guanylate kise 1 2 13
433233 AB040927 Hs 301804 Hs 301804 KIAA1494 protein 2 12
452700 AI859390 Hs 288940 Hs 288940 transmembrane protein 8 (five 2 12
438033 T26483 Hs 6059 NM.016938 Homo sapiens EGF-containmg fi 2 12
400847 2 12
447547 NM 007229 Hs 18842 NM.007229 Homo sapiens protein kise C an 2 12
417052 NM 000712 Hs 81029 NM.000712 Homo sapiens biliverdm reduct 2 12
413284 AU077055 Hs 289107 NM.001166 Homo sapiens bxuloviral IAP r 2 11
434558 AW264102 Hs 39168 Hs 39168 ESTs, Weakly similar to T17340 2 11
404030 2 11
410801 BE275469 Hs 66493 Hs 66493 Down syndrome cndcal region g 2 11
418613 AA744529 Hs 86575 Hs 86575 mitogen-xdvated protein kise 2 11
447087 AW403870 Hs 301872 Hs 301872 hypothedcal protein MGC4840 2 11
433026 AW160616 Hs 279921 NM.016127 Homo sapiens hypothedcal prot 2 11
426433 L38969 Hs 169875 NM.007112 Homo sapiens thrombospondin 3 2 11
442439 U09759 Hs 246857 NM.002752 Homo sapiens mitogen-xdvated 2 11
437379 AL359575 Hs 23765 Hs 23765 membrane metallo-endopepddase- 2 11
400208 2 11
455705 AW161061 Hs 356580 Hs 356580 ESTs, Weakly similar to zinc f 2 11
417599 AA204688 Hs 62954 Hs 62954 femdn, heavy polypeptide 1 2 10
416728 AB024597 Hs 79658 NM_001894 Homo sapiens casein kise 1, ep 2 10
439920 H05430 Hs 288433 Hs 288433 πeurotnmin 2 10
422309 U79745 Hs 114924 NM_004694 Homo sapiens solute earner fa 2 10
436114 AA778232 Hs 19515 Hs 19515 ESTs, Highly similar to NRG3_HU 2 10
405517 2 10
421872 AA359753 Hs 22824 Hs 22824 MYB binding protein (P160) 1a 2 10
437712 X04588 Hs 85844 Hs 85844 πeurotrophic tyrosine kise, rx 2 10
431214 AA294921 Hs 348024 NM_002881 Homo sapiens v-ral simian leuk 2 10
412856 BE386745 Hs 74631 NM_001728 Homo sapiens basigm (BSG), mR 2 10
442064 AI422867 Hs 88594 Hs 88594 Homo sapiens, clone IMAGE 43329 2 10
434845 BE267057 Hs 325321 Hs 325321 WD repeat domain 18 2 10
426728 NM 007118 Hs 367689 NM.007118 Homo sapiens tnple funcdol d 2 10
419596 BE379320 Hs 91448 NM.007026 Homo sapiens dual spxificity 209
448913 AA194422 Hs 22564 NM.004999 Homo sapiens myosin VI (MY06), 209
414721 X90392 Hs 77091 NM_O06730 Homo sapiens deoxyπbonuclease 209
424658 NM 002406 Hs 151513 NM.002406 Homo sapiens mannosyl (alpha-1 209
432805 X94630 Hs 3107 Hs 3107 CD97 antigen 209
447032 AK000310 Hs 17138 Hs 17138 hypothetical protein FU20303 209
447484 AA464839 Hs 292566 Hs 292566 YEA4 protein 209
440188 AK001812 Hs 7036 Hs 7036 N acetylglucosamine kise 209 209
402559 209
418043 AW377752 Hs 83341 Hs 83341 AXL receptor tyrosine kise 209
448888 AW196663 Hs 200242 Hs 200242 caspase recruitment doman fam 209
436910 AA926944 Hs 261587 Hs 261587 GCN2 elF2alpha kise 209
422573 AW297985 Hs 295726 Hs 295726 integnn, alpha V (vitronxdn 208
416448 L13210 Hs 79339 NM.005567 Homo sapiens Ixdn, galxtosi 208
428727 AF078847 Hs 191356 NM.001515 Homo sapiens general franxπp 208
410301 AW502935 Hs 740 Hs 740 PTK2 protein tyrosine kise 2 208
449538 AI559444 Hs 104679 Hs 104679 Homo sapiens, clone MGC 18216 208
421205 AL137540 Hs 102541 Hs 102541 netππ 4 208
411779 AA292811 Hs 72050 NM_003551 Homo sapiens non-metastatic ce 208
427704 AW971063 Hs 292882 Hs 292882 ESTs 207
413518 BE149455 Hs 75415 NM.004048 Homo sapiens beta-2-mιcroglobu 207
447345 BE247767 Hs 18166 Hs 18166 KIAA0870 protein 207
407143 C14076 Hs 332329 Hs 332329 EST 207
448431 BE613061 Hs 337772 Hs 337772 hypothedcal protein BC009331 207
412760 AW379030 Hs 41324 Hs 41324 ESTs 207
446859 AI494299 Hs 16297 NM.005694 Homo sapiens C0X17 homolog, cy 207
403966 207
409115 AI223335 Hs 50651 NM_002227 Homo sapiens Janus kise 1 (a p 207
436823 AW749865 Hs 117077 Hs 117077 zinc finger protein 264 207
414045 NM 002951 Hs 75722 NM_002951 Homo sapiens nbophoπn II (RP 206
413980 NM 002437 Hs 75659 NM_002437 Homo sapiens MpV17 transgene, 206
439414 NM 001183 Hs 65S1 NM_001183 Homo sapiens ATPase, H+ fransp 206
426059 BE292842 Hs 166120 NM_001572 Homo sapiens interferon regula 206
429849 U33053 Hs 2499 NM.002741 Homo sapiens protein kise C-li 206
402424 206
406626 X04526 Hs 215595 Hs 215595 guanine nucleotide binding pro 206
458911 AA373131 Hs 24322 Hs 24322 ATPase, H* transporting, lysoso 205
426086 T94907 Hs 188572 Hs 188572 ESTs 205
419726 U50330 Hs 1274 NM.006129 Homo sapiens bone orphogened 205
452344 AI264357 Hs 55405 Hs 55405 hypothetical protein MGC16212 205
442498 U54617 Hs 8364 NM.002612 Homo sapiens pyruvate dehydrog 205
422114 AW194851 Hs 111801 NM.015908 Homo sapiens arsete resistance 205
413420 AW410235 Hs 75348 NM_006263 Homo sapiens proteasome (proso 205
409430 R21945 Hs 346735 Hs 346735 Homo sapiens, clone IMAGE 3881 205
409932 AI376750 Hs 57600 Hs 57600 adaptor-related protein complex 205
434848 BE256304 Hs 32148 Hs 32148 AD-015 protein 204
453852 AW961818 Hs 374424 Hs 374424 ESTs 204
427637 AK000816 Hs 179986 NM_005803 Homo sapiens flotillm 1 (FLOT 204
400264 204
430016 NM 004736 Hs 227656 NM.004736 Homo sapiens xenotropic and po 204
410134 U68140 Hs 58927 Hs 58927 nuclear VCP-like 204
440975 AW499914 Hs 7579 Hs 7579 importin 9 204
432280 BE440142 Hs 2943 NM_003135 Homo sapiens sigl recogmdon 204
409504 AA304961 Hs 699 NM_000942 Homo sapiens pepddylprolyl is 204
412146 M92444 Hs 73722 NM.001641 Homo sapiens APEX nuclease (mu 204
434203 BE262677 Hs 283558 Hs 283558 hypothetical protein PR01855 204
422754 AA316476 Hs 171811 Hs 171811 adenylate kise 2 204
406729 AA069711 AA069711 zm52b11 s1 Stratagene fibroblas 204
413086 AA126841 Hs 183834 Hs 183834 ESTs 203
424340 AA339036 Hs 7033 Hs 7033 ESTs 203
450440 AB024334 Hs 25001 NM_012479 Homo sapiens tyrosine 3-monoox 203
424662 NM 002870 Hs 151536 NM_002870 Homo sapiens RAB13, member RAS 203
415740 N80486 Hs 39911 Hs 39911 Homo sapiens mR for FLJ00089 pr 203
412749 AA378417 Hs 74564 NM.0031 5 Homo sapiens sigl sequence rx 203
408393 AW015318 Hs 23165 Hs 23165 ESTs 203
421295 AW081061 Hs 103180 Hs 103180 DC2 protein 203
445417 AK001058 Hs 12680 Hs 12680 Homo sapiens cD FU10196 fis, c 203
414883 AA926960 Hs 348669 NM.001826 Homo sapiens CDC28 protein kis 203
447298 BE617527 Hs 239818 Hs 239818 phosphoιnosιtιde-3-kιse, catal 202
459580 AA022888 Hs 176065 Hs 176065 ESTs 202
422785 AI824114 Hs 289088 Hs 289088 heat shxk 90kD protein 1, alp 202
452696 AI826645 Hs 211534 Hs 211534 Homo sapiens cD FLJ31665fis, 202
452056 AW955065 Hs 101150 Hs 101150 KIAA1949 protein 202
450690 AA296696 Hs 333418 NM_014164 Homo sapiens FXYD doman-conta 202
423527 AI206965 Hs 105861 Hs 105861 engulfment and cell modlity 3 201
429545 AI824164 Hs 356130 Hs 356130 ESTs 201
439180 AI393742 Hs 199067 Hs 199067 v-erb-b2 erythroblastic leukem 201
437193 BE259190 Hs 289721 Hs 289721 growth aπest-spxific 5 201
436014 AF281134 Hs 283741 Hs 283741 exosome component Rrp46 201
453329 T97205 Hs 193400 Hs 193400 interieukin 6 rxeptor 201
407347 AA829847 T23514 seq3329 1-NIB Homo sapiens cD do 201
435370 AI964074 Hs 225838 Hs 225838 ESTs 201
430657 AA482910 Hs 370602 Hs 370602 ESTs, Weakly similar to hypoth 201
427157 U51166 Hs 173824 NM_003211 Homo sapiens thymine-D glycosy 201
424833 NM.003894 Hs 153405 NM_0O3894 Homo sapiens peπod homolog 2 201
440086 NM 005402 : Hs 6906 NM_005402 Homo sapiens v-ral simian leuk 201
438543 AA810141 Hs 192182 Hs 192182 ESTs 201
417426 NM.002291 Hs 82124 NM_002291 Homo sapiens laminin, beta 1 ( 201
412790 NM 014767 ' Hs 74583 NMJ514767 Homo sapiens KIAA0275 gene pro 201
445892 AV655500 Hs 93961 Hs 93961 Homo sapiens mR, cD DKFZp667D09 201 TABLE 38B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT Number Accession 409745 MH1944_5 BI030997 AA921874 AW188822 BI027862 AI347618 AI361453 AI088754 AW207491 AA077391 BG012775 BG997382 AA286833 AA150722 BI007625
BI027864 BI009100 BI00627S BI006270 BI031000 BI029864 BI006277 BI007627 BI006266 BI006991 BI006990 BI007763 BI0O7762 BG997377
AA150780 BI033518 BI027818 BG015789 BI033807 AA341445
419671 253275 1 N64410 AA248866 AA248779 W02010 437495 65231 J AL390180 AA359908 BE177778 BE177779 AW893733 BF756318 418869 12789 14 AA229762 AA230035 432648 129028J AA677593 AA618150AA557952 421902 276321 BG171436 BE079601 BE079534 AA299964 BE392717 BE883402 BE079532 BE018148 BF889427 W00396 414667 MH1944 5 BI030997 AA921874 AW188822 BI027862 AI347618 AI361453 AI088754 AW207491 AA077391 BG012775 BG997382 AA286833 AA150722 BI007625
BI027864 BI009100 BI006275 BI006270 BI031000 BI029864 BI006277 BI007627 BI006266 BI006991 BI006990 BI007763 BI007762 BG997377
AA150780 BI033518 BI027818 BG015789 BI033807 AA341445
435185 127115.1 AW173494 AI804346 AA669490 411331 1076355.1 AW837178 T77002 F13038 451876 2328579.1 T63141 AI821021 BF370092 BF370127 BF370060 T62998 400261 23110.1 BC006097 X03066 NM.002120 M26040 AW469119 AW469127 AI299772 AW518149 AI144456 AW628070 AI629032 AI358810 AI880433 AI440472
AI357070 AI865365 AW014799 AI767973 AW518041 AA909398 AW768606
439195 21979 1 AF086037 H89360 H89546 454694 1066666.1 AW936378 AW936544 AW813513 416913 924456.1 AW934714 AW749864 AW749902 BE162498 BE161005 BE162499 BE161006 AA190449 AW513465 BE162500 BE161007 459362 1238130.1 AW974073 T56957
TABLE 38C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column ae Genbank Identifier (Gl) numbers "Dunham, et al * refers to the publicadon endtled "The DNA sequence of human chromosome 22* Dunham, et al (1999) Nature 402489-495 Strand Indicates DNA strand from which exons were predicted
NLposition Indicates nucleotide positions of predicted exons
Pkey Ref Strand NLposidon
403346 8569726 Plus 92752-93015
401621 8570184 Minus 193-608
403344 8569726 Plus 70823-70990
404240 5002624 Minus 116132-116407,116653-116922
401964 3126781 Minus 13510-13725,13847-14015
404277 1834458 Minus 91665-91946
405121 8102330 Minus 35816-36004,36587-36684
402493 9797670 Minus 205146-205240,205428-205542
402121 9188523 Plus 25692-25895
402474 7547175 Minus 53526-53628,55755-55920,57530-57757
403887 7710553 Minus 69533-69868
403328 8469086 Minus 120428-120703
401241 4827300 Minus 30503-30844,31056-31248
401736 3219338 Bus 1771-1894
405029 7533975 Minus 37929-38224
404171 9930793 Plus 173667-173783,176876-177055
401797 6730720 Plus 6973-7118
401234 9929642 Plus 120173-120337
404170 9930793 Plus 168836-169248
406122 9144087 Minus 30940-31386
TABLE 39A 856 GENES UP-REGULATED IN RENAL CANCER COMPARED TO NORMAL ADULT TISSUES AND TO NON-MALIGNANT RENAL TISSUES THAT ARE LIKELY TO ENCODE PROTEINS AMENABLE TO MODULATION BY SMALL MOLECULES, PEPTIDES, OR ANTIBODIES
Table 39A lists about 856 genes up-regulated in renal cancer compared to normal adult dssues and to non-malignant renal tissues that are likely to encode proteins amenable to modulation by small molxules, peptides, or antibodies These were selxted from the starting collxdon of 59680 probesets on the Affymetnx/Eos-Hu03 GeneChip® array as follows the ratio of 'average* renal cancer to 'average* normal adult tissues was greater than or equal to 20, the ratio of "average" renal cancer to "average' non-malignant renal tissues was greater than or equal to 20, Ihe 'average' renal cancer level was set to the 90th percendle value amongst vanous renal spximens, the "average* normal adult dssue level was set to the 70th percendle value amongst vanous non-malignant tissues, the "average* non-malignant renal tissues level was set to the 50th percendle value amongst various non-malignant renal tissues, the 'average* renal cancer value was greater than or equal to 50 units, and the predicted protein contained a structural domain that is indicative of having an oncogenic function or of transducing an intracellular signal, or of being modulatable by small molxules, pepddes, or andbodies (e g pkinase, death-domain, 7tm, phosphatase, or lon.transporter)
Pkey Uniqi ιe Eos probeset identifier number
ExAccn Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dde
R1 Ratio of tumor to normal adult dssues
Pkey ExAccn UnigenelD Unigene Tide R1
435013 H91923 Hs 110024 1571
447768 X86400 Hs 19520 Hs 19520 FXYD doman-contanmg ion tran 1407
445178 AI792241 Hs 129614 Hs 129614 kidπey-spxific membrane prote 1256
432542 AW083920 Hs 16098 Hs 16098 claudin 2 1241
443595 AF169312 Hs 9613 NM.016109 Homo sapiens angiopoiedn-like 1177
413719 BE439580 Hs 75498 NM 004591 Homo sapiens small inducible c 1039
436878 BE465204 Hs 47448 Hs 47448 ESTs 1018
440304 BE159984 Hs 125395 Hs 125395 ESTs 995
407065 Y10141 958 413049 NM 002151 HS 823 NM.002151 Homo sapiens hepsin (transme b 951
425983 AK000226 Hs 165619 Hs 165619 mucin and cadheπn-like
423161 AL049227 Hs 124776 Hs 124776 Homo sapiens mR, cD DKFZp564N1 877
430569 AF241254 Hs 178098 Hs 178098 angiotensm I converting enzym 845
416768 AA363733 Hs 1032 NM_0O2909 Homo sapiens regenerating isle 794
422357 AF016272 Hs 115418 NM.004062 Homo sapiens cadhenn 16, KSP- 778
420737 L08096 Hs 99899 NM 001252 Homo sapiens tumor nxrosis fa 778
409745 AA077391 AA077391 7B14E 12 Chromosome 7 Fetal Bra 774
413936 AF113676 Hs 297681 NM.000295 Homo sapiens senne (or cystei 732
426682 AV660038 Hs 2056 Hs 2056 UDPglycosyltransferase 1 family 720
406851 AA609784 Hs 352392 Hs 352392 major histocompadbility compl 703
419508 AW997938 Hs 90786 Hs 90786 ATP-bindmg cassette, sub-famil 6 57
428953 AA306610 Hs 348183 NM.003823 Homo sapiens tumor nxrosis fa 636
436895 AF037335 Hs 5338 NM_001218 Homo sapiens carbonic anhydras 631
431842 NM 005764 Hs 271473 NM_0O5764 Homo sapiens epithelial protei 6 20
430014 H59354 Hs 374303 Hs 374303 hypothedcal protein MGC20576 620
423803 NM 005709 Hs 132945 NM_005709 Homo sapiens PDZ-73 protein (P 6 19
434779 AF153815 Hs 50151 Hs 50151 potassium inwardly-rxdfying c 6 11
435767 H73505 Hs 117874 Hs 117874 ESTs 608
422664 AA315933 Hs 120879 Hs 120879 Homo sapiens, clone MGC 32871 602
425280 U31519 Hs 1872 Hs 1872 phosphoenolpyruvate carboxykise 581
426559 AB001914 Hs 170414 NM_002570 Homo sapiens paired basic amm 573
451564 AU076698 Hs 132760 NM.001467 Homo sapiens glucose-6-phospha 569
418526 BE019020 Hs 85838 NM.004207 Homo sapiens solute earner fa 568
444151 AW972917 Hs 128749 Hs 128749 alpha-methylxyl-CoA rxemase 566
426471 M22440 Hs 170009 NM.003236 Homo sapiens transforming grow 548
432579 AF043244 Hs 278439 NM.003946 Homo sapiens nucleolar protein 545
448733 NM 005629 Hs 187958 NM_005629 Homo sapiens solute earner fa 542
446650 AB016625 Hs 15813 NM.0O3060 Homo sapiens solute earner fa 536
417089 H52280 Hs 18612 Hs 18612 Homo sapiens cD FU21909 fis, 5 35
437848 AI906419 Hs 284380 Hs 284380 gamma-glutamyltransferase 1 5 32
423081 AF262992 Hs 123159 Hs 123159 sperm assxiated andgen 4 530
421893 NM 001078 Hs 109225 NM.001078 Homo sapiens vascular cell adh 523
435886 BE265839 Hs 12126 Hs 12126 hepatxellular carcmoma-assxi 520
410276 AI554545 Hs 359201 Hs 359201 ESTs 5 20
429451 BE409861 Hs 202833 NM_ 02133 Homo sapiens heme oxygese (dx 5 14
446404 AA019961 Hs 26216 Hs 26216 Homo sapiens cD FU22811 fis 5 13
423445 NM.014324 Hs 128749 NM_014324 Homo sapiens alpha-methylxyl- 509
449444 AW818436 Hs 351306 NM_004696 Homo sapiens solute earner fa 505
438106 BE245551 Hs 6079 NM_014863 Homo sapiens B cell RAG assxi 502
400419 AF084545 AF084545 Homo sapiens versican Vint isof 501
453920 AI133148 Hs 36602 NM.000204 Homo sapiens I fxtor (complem 499
447881 BE620886 Hs 355279 Hs 355279 Homo sapiens cD FU23711 fis, 497
422253 W81526 Hs 113882 NM_000815 Homo sapiens gamma-aminobutyπ 493
439024 R96696 Hs 35598 Hs 35598 ESTs 4 88
414799 AI752416 Hs 77326 NM_O0O598 Homo sapiens iπsulm-like grow 480
426530 U24578 Hs 278625 NM_000592 Homo sapiens complement compon 4 77
410055 AJ250839 Hs 58241 Hs 58241 gene for seπne/threon e prote 4 72
404240 471
414617 AI339520 Hs 288817 Hs 288817 hypothetical protein FLJ22761 468
448249 AW855331 Hs 337124 Hs 337124 ESTs 467
447818 W79940 Hs 21906 Hs 21906 Homo sapiens clone 24670 mR seq 466
449057 AB037784 Hs 22941 Hs 22941 KIAA1363 protein 466
422424 AI186431 Hs 296638 NM_004864 Homo sapiens prostate difleren 462
417336 R70429 Hs 81988 NM_001343 Homo sapiens disabled homolog 4 62
425873 NM 013390 Hs 160417 NM_013390 Homo sapiens transmembrane pro 4 58
444700 NM 003645 Hs 11729 NM_003645 Homo sapiens fatty-xid-Coenzy 4 58
414998 NM 002543 Hs 77729 NM_002543 Homo sapiens oxidised low dens 4 56
414763 U97276 Hs 77266 NM_002826 Homo sapiens quiesciπ 06 (QSCN 4 48
443358 H65417 Hs 17757 Hs 17757 plxkstnn homology doman-coπt 445
440091 AI767388 Hs 37890 Hs 37890 Homo sapiens, clone I AGE 48275 443
447131 NM 004585 Hs 17466 NM_004585 Homo sapiens rednoic xid rx 443
406973 M34996 Hs 198253 Hs 198253 maior histocompadbility compl 442
427740 BE242604 Hs 180616 NM_005505 Homo sapiens CD36 antigen (col 4 40
436258 AW867491 Hs 107125 Hs 107125 plasmatemma vesicle assxiated 4 38
452884 C05964 Hs 31841 Hs 31841 ESTs 437
444006 BE395085 Hs 10086 NM_016639 Homo sapiens type I fransmembr 436
422627 BE336857 Hs 118787 NM.000358 Homo sapiens transforming grow 4 35
418054 NM 002318 Hs 83354 NM_002318 Homo sapiens lysyl oxidase-lik 434
419011 H56244 Hs 89552 NM_000846 Homo sapiens glutathione S-tra 4 34
404277 433
435563 AF210317 Hs 95497 Hs 95497 solute earner family 2 (fxili 4 30
431779 AW971178 Hs 268571 NM.001645 Homo sapiens apolipoprotein C- 429
406645 M57466 Hs 814 Hs 814 major histocompadbility complex, 4 28
421485 AA243499 Hs 104800 Hs 104800 hypothetical protein FU10134 4 26
426812 AF105365 Hs 172613 NM_006598 Homo sapiens solute earner fa 4 25
407910 AA650274 Hs 41296 NMJ513281 Homo sapiens fibronxtin leuci 4 22
438030 X98427 Hs 122634 Hs 122634 ESTs 4 22
430661 AC005551 Hs 130714 Hs 130714 ESTs, Moderately simila to AF 421
444381 BE387335 Hs 283713 Hs 283713 hypothedcal protein BC014245 4 20
438203 BE540090 Hs 7345 Hs 7345 MAD1 mitodc arrest delicient-li 4 16
411358 R47479 Hs 94761 Hs 94761 KIAA1691 protein 4 15
418323 NM.002118 Hs 1162 NM_002118 Homo sapiens major histocompat 4 12 449853 AF006823 Hs 24040 NM_0O2246 Homo sapiens potassium channel 4 11
415198 AW009480 Hs 943 NM.004221 Homo sapiens tural killer cell 411
418751 BE389014 Hs 372548 Hs 372548 phosphomosιdde-3-kιse, regul 409
414166 AW888941 Hs 75789 NM.006096 Homo sapiens N-myc downstream 407
424125 M31669 Hs 1735 Hs 1735 inhibm, beta B (xdvin AB beta 400
416926 H03109 Hs 263395 Hs 263395 sema domain, transmembrane dom 392
419175 AW270037 Hs 362996 Hs 362996 KIAA0779 protein 392
424218 AF031824 Hs 143212 NM.0 3650 Homo sapiens cystadn F (leuko 391
412870 N22788 Hs 82407 Hs 82407 chemokine (C-X-C modf) ligand 388
452203 X57522 Hs 352018 NM_000593 Homo sapiens transporter 1 , AT 387
446872 X97058 Hs 16362 NM 004154 Homo sapiens pyπmidinergic re 387
449961 AW265634 Hs 133100 Hs Ϊ33100 ESTs 387
424517 AI539443 Hs 137447 Hs 137447 Homo sapiens cD FLJ12169 fis, 386
425262 D87119 Hs 155418 Hs 155418 GS3955 protein 383
443639 BE269042 Hs 9661 NM.002801 Homo sapiens proteasome (proso 382
448133 AA723157 Hs 73769 NM.000802 Homo sapiens folate receptor 1 381
418030 BE207573 Hs 83321 Hs 83321 neuromedin B 381
412939 AW411491 Hs 75069 NM.005412 Homo sapiens senne hydroxymet 380
409162 H25530 Hs 50868 NM_002555 Homo sapiens solute earner fa 379
427715 BE245274 Hs 180428 Hs 180428 KIAA1181 protein 378
412006 AW451618 Hs 290216 Hs 290216 ESTs 377
430413 AW842182 Hs 241392 NM.002985 Homo sapiens small inducible c 376
422282 AF019225 Hs 114309 Hs 114309 apolipoprotein L 1 376
420747 BE294407 Hs 99910 Hs 99910 phosphoftuctokise, platelet 376
414875 H42679 Hs 77522 NM_006120 Homo sapiens major histocompat 375
418793 AW382987 Hs 88474 Hs 88474 prostaglaπdm-endoperoxide synt 374
446291 BE397753 Hs 14623 NM_006332 Homo sapiens interferon, gamma 371
417289 D86962 Hs 81875 Hs 81875 growth fxtor receptor-bound pr 369
422672 X12784 Hs 119129 NM_O01845 Homo sapiens collagen, type IV 368
448569 BE382657 Hs 21486 NM_007315 Homo sapiens sigl transducer a 368
437270 R18087 Hs 323769 Hs 323769 cisplatin resistance related p 367
408452 AA054683 Hs 192455 Hs 192455 ESTs, Moderately similar to hy 367
443986 AI381750 Hs 283437 Hs 283437 HTGN29 protein 366
418869 AW516565 AW516565 xq01d05 x1 Soares_NHCeC_cervιca 365
425998 AU076629 Hs 165950 NM.002011 Homo sapiens fibroblast growth 362
428699 AW578252 Hs 190161 NM_014020 Homo sapiens LR8 protein (LR8) 362
418299 AA279530 Hs 83968 NM_000211 Homo sapiens integnn, beta 2 361
432593 AW301003 Hs 51483 Hs 51483 Homo sapiens. Similar to RIKEN 359
415765 NM 005424 Hs 78824 NM_005424 Homo sapiens tyrosine kise wit 3 58
445985 BE621800 Hs 29444 Hs 29444 putadve small membrane protein 357
424893 AW295112 Hs 153648 Hs 153648 protein tyrosine phosphatase, 3 57
426046 AA833655 Hs 206868 Hs 206868 Homo sapiens cD FU 14056 fis, 357
424415 NM 001975 Hs 146580 NM.001975 Homo sapiens enolase 2, (gamma 357
412612 NM_000047 Hs 74131 NM_000047 Homo sapiens arγlsulfatase E ( 356
443834 AI741510 Hs 173548 Hs 173548 ESTs 354
431630 NM 002204 Hs 265829 NM_002204 Homo sapiens integnn, alpha 3 353
418371 M13560 Hs 84298 Hs 84298 CD74 antigen (mvanant polypep 352
444838 AV651680 Hs 208558 Hs 208558 ESTs 352
449378 AW664026 Hs 59892 Hs 59892 ESTs, Weakly similar to alpha 5 352
411393 AW797437 Hs 69771 NM_001710 Homo sapiens B-fxtor, properd 350
414311 AI693547 Hs 71746 Hs 71746 aminopepddase-like 1 350
415149 X12451 Hs 78056 NM.001912 Homo sapiens cathepsin L (CTSL 350
424321 W74048 Hs 1765 Hs 1765 lymphxyte-spxific protein tyro 349
414825 X06370 Hs 77432 NM.0O5228 Homo sapiens epidermal growth 348
408194 AA601038 Hs 191797 Hs 191797 ESTs 348
410600 AW575742 Hs 351676 Hs 351676 ESTs, Weakly similar to T02670 347
416899 BE262645 Hs 80420 NM_002996 Homo sapiens small inducible c 347
436856 AI469355 Hs 127310 Hs 127310 hypothedcal protein BC014917 347
419660 BE280337 Hs 194693 NM_003982 Homo sapiens solute earner fa 347
413566 AW604451 Hs 285814 Hs 285814 growth fxtor receptor-bound p 347
412104 AW205197 Hs 240951 Hs 240951 ked cuticle homolog 2 (Drosoph 346
444488 AW192879 Hs 355660 Hs 355660 peptide-hisddme transporter 346
449475 AI348027 Hs 108557 Hs 108557 hypothetical protein PP1057 346
412276 BE262621 Hs 73798 NM_O02415 Homo sapiens xrophage migrat 345
449338 H73444 Hs 394 NM_001124 Homo sapiens adrenomedullm (A 344
430304 AL122071 Hs 238927 Hs 238927 Homo sapiens mR, cD DKFZp434H1 343
415388 AF018081 Hs 78409 (lxuslιnk)NM_030582 Homo sapiens collag 343
432210 AI567421 Hs 273330 Hs 273330 agπn 343
418177 N44967 Hs 351554 Hs 351554 Homo sapiens cD FLJ32092 fis, 342
414888 AL039185 Hs 77558 Hs 77558 thyroid hormone rxeptor mtera 342
452445 AB002438 Hs 29596 Hs 29596 Homo sapiens mR from chromosome 341
414803 X03100 Hs 914 Hs 914 major histocompadbility complex, 341
419201 M22324 Hs 1239 NM_001150 Homo sapiens alanyl (membrane) 341
445139 AB037848 Hs 12365 Hs 12365 syptotagmm XIII 341
435021 AA922192 Hs 73962 Hs 73962 EphA7 341
417259 AW903838 Hs 81800 Hs 81800 chondroidn sulfate proteoglyca 340
439737 AI751438 Hs 41271 Hs 41271 Homo sapiens mR full length ins 339
410636 AA088177 Hs 172870 Hs 172870 KIAA1913 protein 339
431590 AB037789 Hs 263395 Hs 263395 sema domain, transmembrane dom 338
415000 AW025529 Hs 239812 Hs 239812 serologically defined breast c 336
416700 AW498958 Hs 343475 NM_001909 Homo sapiens cathepsin D (lyso 336
440516 S42303 Hs 161 NM.001792 Homo sapiens cadheπn 2, type 335
423720 AL044191 Hs 23388 Hs 23388 hypothetical protein DKFZp434F0 332 421902 BE392717 BE392717601307571F1 NIH.MGC.44 Homo sap 332
409220 BE243323 Hs 51233 Hs 51233 tumor nxrosis fxtor rxeptor 332
421502 AF111856 Hs 105039 NM_0 6424 Homo sapiens solute earner fa 332
416729 U46165 Hs 1027 NM_O04165 Homo sapiens Ras-related ass∞ 330
430302 AL137502 Hs 238679 Hs 238679 Rag D protein 330
445084 H38914 Hs 250848 Hs 250848 Homo sapiens cD FU14761 fis, 329
406825 AI982529 Hs84298 Hs 84298 CD74 andgen (mvanant polypep 329
446272 BE268912 Hs 14601 NM.005335 Homo sapiens hematopoiedc cel 328
437145 AF007216 Hs5462 NM 003759 Homo sapiens solute earner fa 327
444071 AI627808 Hs 110524 Hs Ϊ10524 ESTs 327
414662 AL036058 Hs 76807 Hs 76807 maior histxompadbility comple 327
436576 AI458213 Hs 77542 Hs 77542ESTs, Weakly similar to S26650 326
424675 NM 005512 Hs 151641 NM_005512 Homo sapiens glycoprotein A re 325
437897 AA770561 Hs 146170 Hs 146170 hypothedcal protein FU22969 325
449703 H61001 Hs 171802 Hs 171802-Homo sapiens, clone IMAGE 3956 325
414788 X78342 Hs77313 NM_003674 Homo sapiens cyclm-dependent 325
414249 AI797994 Hs 279929 Hs 279929 gp25L2 protein 324
430396 D49742 Hs 241363 NM_004132Homo sapiens hyaluron binding 323
424456 AA341017 Hs 25549 Hs 25549 hypothedcal protein FU20898 323
452303 R27257 Hs 57734 Hs 57734 G protein-coupled rxeptor kise 322
425390 AI092634 Hs 156114 NM_004648 Homo sapiens protein tyrosine 321
416033 NM 012201 Hs78979 NM.012201 Homo sapiens golgi apparatus p 319
450931 N25156 Hs 25648 Hs 25648 tumor nxrosis fxtor receptor 319
428065 AI634046 Hs 157313 Hs 157313 ESTs 318
422616 BE300330 Hs 118725 NM.012248 Homo sapiens selenophosphate s 318
439318 AW837046 Hs6527 Hs 6527 G protein-coupled receptor 56 317
427640 AF058293 Hs 180015 NM.001355 Homo sapiens D-dopxhrome taut 317
409936 AK001691 Hs57655 Hs 57655dudulιn 2 316
436001 AW903849 Hs 173840 Hs 173840 simila to endothelial cell-se 3 16
451154 AA015879 Hs 33536 Hs 33536 ESTs 316
420256 U84722 Hs 76206 NM.001795 Homo sapiens cadheπn 5, type 3 16
407584 W25945 Hs8173 Hs 8173 hypothedcal protein FU 10803 3 15
428593 AW207440 Hs 185973 NM.003676 Homo sapiens degeneradve sper 3 15
410026 AI912061 Hs 55016 Hs 55016 EPS8-related protein 2 3 15
445333 BE537641 Hs44278 Hs 44278 RAB17, member RAS oncogene fami 3 14
448143 AF039704 Hs 20478 NM.000391 Homo sapiens ceroid-lipofusciπ 3 14
423007 AA320134 Hs 196029 Hs Ϊ96029 Homo sapiens R for KIAA1657 p 3 14
416511 NM.006762 Hs 79356 NM_006762 Homo sapiens Lysosomal-assxia 3 14
439237 AW408158 Hs 318893 Hs 318893 ESTs, Weakly similar to Z195_H 3 13
446899 NM 005397 Hs 16426 NM_005397 Homo sapiens podxalyxm-like 313
413916 N49813 Hs 75615 NM_000483 Homo sapiens apolipoprotein C- 3 13
434398 AA121098 HS3838 NM_006622 Homo sapiens senjm-inducible k 3 12
441283 AA927670 Hs 131704 Hs 131704 ESTs 3 12
418945 BE246762 Hs 89499 NM_000698 Homo sapiens arxhidote 5-lιpo 3 12
418458 AA332941 Hs 85226 NM_000235 Homo sapiens lipase A, lysosom 3 12
408989 AW361666 Hs 49500 Hs 49500 KIAA0746 protein 3 11
436906 H95990 Hs 181244 Hs 181244 maior histocompadbility compl 3 11
411089 AA456454 Hs 355702 Hs 355702 ESTs, Weakly similar to AC0048 3 11
432990 AL036071 Hs 279899 NM.OO3820 Homo sapiens tumor nxrosis fa 3 11
425009 X58288 Hs 154151 NM_002845 Homo sapiens protein tyrosine 3 10
443601 AI078554 Hs 42658 Hs 42658 Homo sapiens cD FU30167 fis, c 3 10
430603 AA148164 Hs 247280 Hs 247280 chromosome 20 open reading fra 3 10
413672 BE156536 Hs 353632 Hs 353632 ESTs, Moderately similar to hy 309
407786 AA687538 Hs 38972 NM_005727 Homo sapiens tetraspaπ 1 (TSPA 309
414586 AA306160 Hs 16488 NM_002298 Homo sapiens lymphxyte cytoso 308
423712 W46802 Hs 81988 Hs 81988 disabled homolog 2, mitogen-res 308
438552 AJ245820 Hs 6314 NM_012410 Homo sapiens type I transmembr 306
448364 T08958 Hs 297214 Hs 297214 HSPC141 protein 306
426437 BE076537 Hs 169895 NM_004223 Homo sapiens ubiquidn-coπjuga 306
437679 NM 014214 Hs5753 NM.014214 Homo sapiens ιnosιtol(myo)-1(o 306
422262 AL022315 Hs 113987 NM.006498 Homo sapiens tectin, galxtosi 306
410480 R97457 Hs 63984 NM_001257 Homo sapiens cadheπn 13, H-ca 305
435818 AA700553 Hs 368614 Hs 368614 ESTs 305
418883 BE387036 Hs 1211 NM_001611 Homo sapiens xid phosphatase 305
453613 F06838 Hs 374476 Hs 374476 ESTs 305
408051 AI623351 Hs 172148 Hs 172148 ESTs 305
432278 AL137506 Hs 274256 Hs 274256 hypothedcal protein FU23563 304
407949 W21874 Hs 247057 Hs 247057-ESTs, Weakly similar to 210926 304
418090 U57059 Hs 83429 NM.003810 Homo sapiens tumor nxrosis fa 304
433165 AA578904 Hs 292437 Hs 292437ESTS 303
425809 AA370362 Hs 57958 Hs 57958 EGF-TM7-latrophιlιn-related pro 303
443884 N20617 Hs 194397 Hs 194397 ESTs, Moderately similar to 22 303
447831 AI433293 Hs 164115 Hs 164115 ESTs 302
413278 BE563085 Hs833 NM.005101 Homo sapiens inteiferon-sdmul 301
418870 AF147204 Hs 89414 Hs 89414 chemokine (C-X-C modf), recept 300
456376 AA663904 Hs89862 Hs 89862 TNFRSF1 A-assxiated via death d 300
439738 BE246502 Hs9598 Hs 9598 sema domain, immunoglobulin doma 300
444416 AW288085 Hs 11156 NM.016494 Homo sapiens hypothedcal prot 300
406656 M16714 Hs 89643 Hs 89643 transketolase (Wemicke-Korsako 300
406826 AW516005 Hs 84298 Hs 84298 CD74 andgen (mvanant polypep 299
418707 U97502 Hs 87497 Hs 87497 butyrophilin, subfamily 3, memb 299
421742 AW970004 Hs 107528 NM.016108 Homo sapiens androgen induced 299
406824 AW515961 Hs 84298 Hs 84298 CD74 andgen (mvanant polypep 299 435605 AF151815 Hs 4973 NM.015680 Homo sapiens hypothedcal prot 298
410491 AA465131 Hs 64001 Hs 64001 Homo sapiens clone 25218 mR seq 298
427648 AI376722 Hs 180062 NM_004159 Homo sapiens proteasome (proso 298
411125 AA151647 Hs 68877 NM.000101 Homo sapiens cytochrome b-245, 298
435550 AI224456 Hs 324507 Hs 324507 hypothedcal protein FU20986 298
429373 NM 014694 Hs 200594 NM.014694 Homo sapiens KIAA0605 gene pro 298
445701 AF055581 Hs 13131 NM.005475 Homo sapiens lymphxyte adapto 297
414649 AI672727 Hs 76753 NM_000118 Homo sapiens endoglm (Osler-R 297
444207 AI565004 Hs 374415 Hs 374415 ESTs 297
423225 AA852604 Hs 125359 NM_006288 Homo sapiens Thy-1 cell surfx 297
407792 AI077715 Hs 39384 NM_014344 Homo sapiens four jointed box 297
445707 AI248720 Hs 114390 Hs 114390 ESTs 296
452888 AW955454 Hs 30942 NM.004093 Homo sapiens ephπn-B2 (EFNB2) 296
418478 U38945 Hs 1174 Hs 1174 cydin-dependent kise inhibitor 295
411441 AL042355 Hs 70202 Hs 70202 WD repeat doman 10 295
443426 AF098158 Hs 9329 Hs 9329 chromosome 20 open reading frame 294
450876 AF189062 Hs 285976 Hs 285976 LAG1 longevity assurance homol 294
426359 AA376409 Hs 10862 Hs 10862 Homo sapiens cD FU23313 fis, 294
425421 L11669 Hs 157145 NM_001120 Homo sapiens tetrxyclme tran 293
449879 H03573 Hs 287830 Hs 287830 Homo sapiens mR, cD DKFZp434E1 293
454075 R43826 Hs 16313 Hs 16313 Kruppel-like zinc finger protei 293
421595 AB014520 Hs 301685 Hs 301685 KIAA0620 protein 293
457949 W69171 Hs 334814 Hs 334814 hypothedcal protein FU14868 292
443987 AW163123 Hs 10071 NM_016551 Homo sapiens seven transmembra 292
430259 BE550182 Hs 375142 Hs 375142 RalGEF-like protein 3, mouse h 292
415906 AI751357 Hs 288741 Hs 288741 Homo sapiens cD FU22256 fis, 291
429762 AI346255 Hs 216354 NM_006913 Homo sapiens πng finger prote 291
451527 AF022813 Hs 26518 NM.003271 Homo sapiens transmembrane 4 s 291
425356 BE244879 Hs 155939 NM.0O5541 Homo sapiens inositol polyphos 291
427080 AW068287 Hs 301175 NM_002872 Homo sapiens ras-related C3 bo 291
426432 AF001601 Hs 169857 NM.000305 Homo sapiens par∞xose 2 (PON2 290
431476 BE612705 Hs 256697 Hs 256697 histidine toad nudeodde bin 289
406659 AA663985 Hs 277477 Hs 277477 ma|or histocompadbility compl 289
451144 AW956103 Hs 61712 Hs 61712 Homo sapiens cD FU31548 fis c 289
456362 AW973003 Hs 179909 Hs 179909 nuclea rxeptor coxdvator 6 288
426440 BE382756 Hs 169902 NM_006516 Homo sapiens solute earner fa 288
456974 M12529 Hs 169401 NM_000041 Homo sapiens apolipoprotein E 288
418174 L20688 Hs 83656 Hs 83656 Rho GDP dissxiadon inhibitor 288
446055 AI815981 Hs 12909 Hs 12909 mucolipin l 288
423184 NM 004428 Hs 1624 NM_0O4428 Homo sapiens ephπn-A1 (EF1), 287
427700 AA262294 Hs 180383 NM_001946 Homo sapiens dual spxificity 2 87
410668 BE379794 Hs 159651 NM_016629 Homo sapiens hypothedcal prot 287
444143 AW747996 Hs 160999 Hs 160999 ESTs, Weakly simila to I78885 287
407151 H25836 Hs 301527 Hs 301527 ESTs, Moderately similar to un 2 86
449349 AI825386 Hs 352579 Hs 352579 Homo sapiens, chromosome 20 op 286
436997 AA741151 Hs 137323 Hs 137323 ESTs 2 86
446143 BE245342 Hs 306079 NM_013336 Homo sapiens protein transport 286
417355 D13168 Hs 82002 Hs 82002 endothelin rxeptor type B 2 86
431685 AW296135 Hs 267659 NM_006113 Homo sapiens vav 3 oncogene (V 286
408877 AA479033 Hs 130315 Hs 130315 ESTs 2 85
429615 AF258627 Hs 211562 NM_005502 Homo sapiens ATP-bmding casse 285
412014 AI620650 Hs 43761 Hs 43761 gap juncdon protein, alpha 7, 284
436749 AA584890 Hs 5302 NM_006149 Homo sapiens tecdn, galxtosi 2 84
419625 U91616 Hs 182885 NM_004556 Homo sapiens nuclear fxtor of 284
439941 AI392640 Hs 18272 Hs 18272 solute earner family 38, membe 2 84
436496 AA281959 Hs 5210 NM_004877 Homo sapiens glia maturadon f 284
422100 AI096988 Hs 111554 NM.005737 Homo sapiens ADP-πbosyladon 283
439730 AF035292 Hs 6654 Hs 6654 KIAA0657 protein 283
447217 BE465754 Hs 17778 NM.003872 Homo sapiens neuropilin 2 (NRP 283
428343 AL043021 Hs 12705 Hs 12705 simila to HYPOTHETICAL 43 1 KD 282
440524 R71264 Hs 16798 Hs 16798 Homo sapiens mR, cD DKFZp564024 282
415523 AL042003 Hs 296847 NM.003119 Homo sapiens spastic paraplegi 281
439668 AI091277 Hs 302634 Hs 302634 frizzled homolog 8 (Drosophila 281
414570 Y00285 Hs 76473 NM_000876 Homo sapiens insulin-like grow 280
426535 AU077012 Hs 288582 NM.006287 Homo sapiens dssue fxtor pat 2 80
409649 AA159216 Hs 55505 Hs 55505 hypothetical protein FU20442 280
406655 M21533 Hs 277477 Hs 277477 ma|or histocompadbility compl 2 79
415323 BE269352 Hs 949 NM_000433 Homo sapiens neutrophil cytoso 279
443195 BE148235 Hs 193063 Hs Ϊ93063 Homo sapiens cD FU 14201 fis, 278
451356 AA748418 Hs 164577 Hs 164577 ESTs 278
450708 AA376654 Hs 350065 Hs 350065 Homo sapiens cD FU30634 fis, 278
433681 AI004377 Hs 200360 Hs 200360 Homo sapiens cD FU 13027 fis, 277
442599 AF078037 Hs 324051 NM_006663 Homo sapiens RelA-ass∞iated i 2 76
414509 AW161311 Hs 76294 NM.001780 Homo sapiens CD63 andgen (mei 276
431394 AK000692 Hs 252351 Hs 252351 HERV-H LTR-assxiatmg 2 276
417331 AW411297 Hs 81972 Hs 81972 SHC (Src homology 2 domain cont 2 76
415995 NM 004573 Hs 355888 NM_004573 Homo sapiens phospholipase C, 275
414911 NM 000107 Hs 77602 NM_000107 Homo sapiens damage-spxific D 2 75
425976 C75094 Hs 334514 Hs 334514 chromosome 6 open reading fram 275
407893 BE408359 Hs 43621 Hs 43621 hypothetical protein MBC3205 275
407903 AI287341 Hs 154029 Hs 154029 bHLH fxtor Hes4 2 75
416062 AA724811 Hs 334791 Hs 334791 similar to neurol tetraspaπin 275
428494 AA233439 Hs 184634 Hs 184634 hypothedcal protein FU20005 275 421506 BE302796 Hs 105097 NM.003258 Homo sapiens thymidine kise 1, 274
427581 NM 014788 Hs 179703 NM.014788 Homo sapiens bipartite modf- 274
424527 AW138558 Hs 334873 Hs 334873 carboxypepddase M 274
439578 AW263124 Hs 350547 Hs 350547 nuclear rxeptor co-repressor/ 274
425188 AK002052 Hs 155071 Hs 155071 chromosome 20 open reading fra 274
428013 AF151020 Hs 181444 NM.016456 Homo sapiens hypothetical prot 273
439333 AW384710 Hs 132986 Hs 132986 Homo sapiens cD FU31588 fis, 273
450935 BE514743 Hs 355753 NM.005851 Homo sapiens tumor suppressor 273
421532 AW138207 Hs 146170 Hs Ϊ46170 hypothedcal protein FU22969 273
440502 AI824113 Hs 78281 Hs 78281 regulator of G-protem siglling 273
444981 AW855398 Hs 12210 Hs 12210 tumor endothelial marker 6 272
439219 N33883 Hs 41322 Hs 41322 ESTs 272
416847 L43821 Hs 80261 NM_006403 Homo sapiens enhancer of diam 272
433179 AW362945 Hs 162459 Hs 162459 ESTs 272
424528 AW073971 Hs 238954 Hs 238954 ESTs, Weakly similar to putad 271
411213 AA676939 Hs 69285 NM_003873 Homo sapiens neuropilin 1 (NRP 270
433012 NM 004045 Hs 279910 NM_0 4045 Homo sapiens ATX1 andoxidant 270
425345 AU077297 Hs 155894 NM.002827 Homo sapiens protein tyrosine 269
428923 BE047698 Hs 188785 Hs 188785 ESTs 269
427923 AW274357 Hs 301406 Hs 301406 hypothedcal protein PP3501 269
446644 NM 003272 Hs 15791 NM.003272 Homo sapiens transmembrane 7 s 269
421743 T35958 Hs 107614 Hs 107614 DKFZP564I1171 protein 268
416207 NM 014745 Hs 79077 NM.014745 Homo sapiens KIAA0233 gene pro 268
420372 AW960049 Hs 293660 Hs 293660 gene overexpressed in astrocyt 268
420542 NM 000505 Hs 1321 NM.000505 Homo sapiens coagulation fxto 267
425069 AA687465 Hs 298184 Hs 298184 potassium voltage-gated channe 267
418558 AW082266 Hs 86131 NM_003824 Homo sapiens Fas (TNFRSF6)-ass 267
426251 M24283 Hs 168383 NM_O00201 Homo sapiens intercellular adh 266
406701 AA780613 Hs 62954 Hs 62954 femdn, heavy polypepdde 1 266
431681 AK000378 Hs 267566 Hs 267566 hypothedcal protein FLJ20371 266
412833 AW960547 Hs 298262 Hs 298262 πbosomal protein S19 266
433101 AW572317 Hs 12082 Hs 12082 TIGA1 266
414774 X02419 Hs 77274 NM.002658 Homo sapiens plasmmogen xdv 266
427868 AI360119compHs 181013 NM.002629 Homo sapiens phosphoglycerate 266
413929 BE501689 Hs 75617 Hs 75617 collagen, type IV, alpha 2 266
424762 AU 19442 Hs 183684 Hs 183684 eukaryodc translation inidat 266
422048 NM 012445 Hs 288126 NM_012445 Homo sapiens spondin 2, extrx 265
431350 AI192528 Hs 164537 Hs 164537 ESTs 265
450184 W31096 Hs 237617 Hs 237617 dipepddylpeptidase 9 265
419285 D31887 Hs 89868 Hs 89868 KIAA0O62 protein 265
414217 AI309298 Hs 279898 Hs 279898 Homo sapiens cD FU23165 fis, 264
451253 H48299 Hs 26126 NM_006984 Homo sapiens claudin 10 (CLDN1 264
435905 AW997484 HS 5003 Hs 5003 SUT-ROBO Rho GTPase-xdvadng 264
432581 AU076465 Hs 278441 NM.014634 Homo sapiens KIAA0015 gene pro 263
415782 AA169345 Hs 123177 Hs 123177 hypothedcal protein BC011406 263
430223 NM 002514 Hs 235935 NM.002514 Homo sapiens nephroblastoma ov 263
417526 AA568906 Hs 82240 NM.004177 Homo sapiens syntaxin 3A (STX3 263
409956 AW103364 Hs 727 NM_002192 Homo sapiens inhibin, beta A ( 263
449843 R85337 Hs 24030 NM.001860 Homo sapiens solute earner fa 262
417389 BE260964 Hs 82045 NM.002391 Homo sapiens midkiπe (neuπte 262
446312 BE087853 Hs 171802 Hs 171802 Homo sapiens, clone IMAGE 3956 262
435099 AC004770 Hs 4756 Hs 4756 flap stru ure-spxific endonucl 262
417920 S47833 Hs 82927 NM.004037 Homo sapiens adenosine monopho 262
435702 AI033647 Hs 121001 Hs 121001 Homo sapiens done MGC 45521 262
422959 AV647015 Hs 349256 Hs 349256 paired immunoglobulm-like rx 262
419938 AU076772 Hs 1279 NM.001733 Homo sapiens complement com pon 262
450954 AI904740 Hs 25691 NM_0 5856 Homo sapiens receptor (calcito 261
421753 BE314828 Hs 107911 Hs 107911 ATP-b ding cassette, sub-fami 261
443577 AI078033 Hs 177170 Hs 177170 ESTs, Weakly simila to ALU8_H 261
453886 R66282 Hs 20247 Hs 20247 ESTs 261
421883 X55079 Hs 1437 NMJJ00152 Homo sapiens glucosidase, alph 260
440457 BE387593 Hs 21321 Hs 21321 granule cell differentiation pr 260
410295 AA741357 Hs 356624 Hs 356624 ESTs 259
420679 X57152 Hs 99853 NM_001436 Homo sapiens fibπllaπn (FBL) 259
451558 NM 001089 Hs 26630 NM_001089 Homo sapiens ATP-bindmg casse 259
444672 Z95636 Hs 11669 Hs 11669 laminin, alpha 5 259
408669 AI493591 Hs 78146 Hs 78146 platelet/endothelial cell adhes 259
426194 T50872 Hs 2001 Hs 2001 thromboxane A synthase 1 (platel 259
421814 L12350 Hs 108623 NM_003247 Homo sapiens thrombospondin 2 259
456371 S76825 Hs 89695 Hs 89695 insulin rxeptor 259
429098 AF030249 Hs 196176 NM.001398 Homo sapiens enoyl Coenzyme A 259
414443 AU077268 Hs 76144 NM_002609 Homo sapiens platelet-denved 2 59
428484 AF104032 Hs 184601 NM_003486 Homo sapiens solute caπer fa 259
453309 AI791809 Hs 32949 NM.0 5218 Homo sapiens defensin, beta 1 2 59
412867 AU076861 Hs 74637 NM.003217 Homo sapiens tesds enhanced g 258
432827 Z68128 Hs 3109 Hs 3109 Rho GTPase xdvadng protein 4 258
412669 AW880841 Hs 96908 NM_006034 Homo sapiens p53-ιnduced prote 258
412115 AK001763 Hs 73239 Hs 73239 hypothetical protein FLJ 10901 258
452866 R26969 Hs 268016 Hs 268016 Homo sapiens cD FU21243 fis, 2 58
435129 AI381659 Hs 267086 Hs 267086 ESTs 257
424482 BE268621 Hs 149155 NM_003374 Homo sapiens voltage-dependent 257
410494 M36564 Hs 64016 NM_000313 Homo sapiens protein S (alpha) 256
433895 AI287912 Hs 3628 NM_004834 Homo sapiens mitogen-xdvated 256 442566 R37337 Hs 12111 Hs 12111 ESTs 2 56
417640 D30857 Hs 82353 NM.006404 Homo sapiens protein C recepto 256
442622 NM 000435 Hs 8546 NM.0 0435 Homo sapiens Notch homolog 3 ( 256
430346 AK000331 Hs 297641 Hs 297641 rednoblastoma-ass∞iated fxt 255
419344 U94905 Hs 277445 Hs 277445 dixylglycerol kise, zeta (104 255
426500 NM 014638 Hs 170156 NM.014638 Homo sapiens KIAA0450 gene pro 2 55
408048 NM 007203 Hs 42322 NM.C 7203 Homo sapiens A kise (PRKA) anc 255
450700 AW732799 Hs 25348 NM.005860 Homo sapiens follistadn-like 254
417018 M16038 Hs 80887 NM.002350 Homo sapiens v-yes-1 Yamaguchi 254
419378 R24922 Hs 90078 Hs 90078 nucleodde-suga transporter si 254
422451 AA310753 Hs 42491 Hs 42491 ESTs. Moderately simila to hyp 253
435906 AI686379 Hs 110796 Hs 110796 SA 1 protein 253
400231 253
417849 AW291587 Hs 82733 NM_007361 Homo sapiens nidogeπ 2 (NID2), 253
427380 NM 005534 Hs 177559 NM_005534 Homo sapiens interferon gamma 252
428385 AF112213 Hs 184062 Hs 184062 chromosome 20 open reading fra 252
438000 AI825880 Hs 5985 Hs 5985 non-kise Cdc42 effxtor protein 252
448719 AA033627 Hs 21858 Hs 21858 senne (or cysteine) proteise i 252
422396 W21872 Hs 7907 Hs 7907 L-fucose kise 252
420787 AA564248 Hs 351292 Hs 351292 Homo sapiens cD FU32605 fis, 251
430590 AW383947 Hs 246381 NM_001251 Homo sapiens CD68 andgen (CD6 251
447026 BE313144 Hs 324844 Hs 324844 hypothedcal protein IMAGE3455 251
439223 AW238299 Hs 250618 Hs 250618 UL16 binding protein 2 250
435151 AA348482 Hs 4788 Hs 4788 nicastπn 250
448202 AB002292 Hs 20695 NM.014629 Homo sapiens Rho guanine nude 2 50
449943 AF104266 Hs 24212 Hs 24212 latrophilm 250
425743 BE396495 Hs 159428 Hs 159428 BCL2-assxιated X protein 250
444681 AJ243937 Hs 288316 Hs 288316 chromosome 6 open reading fram 2 50
421643 BE281170 Hs 106357 NM_007126 Homo sapiens valosin-contanin 250
426865 063476 Hs 172813 NM.003899 Homo sapiens Rho guanine nude 250
432306 Y18207 Hs 303090 NM_005398 Homo sapiens protein phosphata 249
421846 AA017707 Hs 1432 NM_002743 Homo sapiens protein kise C su 249
421905 AI660247 Hs 32699 Hs 32699 Homo sapiens, Simila to RIKEN 249
419493 AF001212 Hs 90744 NM_0O2815 Homo sapiens proteasome (proso 249
422530 AW972300 Hs 118110 NM.004335 Homo sapiens bone maπow strom 248
442821 BE391929 Hs 8752 NM_014255 Homo sapiens transmembrane pro 248
416919 T97839 Hs 80464 NM_006402 Homo sapiens hepadds 8 virus 248
443105 X96753 Hs 9004 NM_001897 Homo sapiens chondroidn sulfa 248
430040 AW503115 Hs 227823 NM_014287 Homo sapiens pM5 protein (PM5) 248
428028 U52112 Hs 182018 NM_0O1569 Homo sapiens ιnterleukιn-1 rx 247
424307 AW293399 Hs 356377 Hs 356377 Homo sapiens, clone IMAGE 3633 246
434511 R28982 Hs 18106 Hs 18106 ESTs, Weakly similar to T06291 246
454390 AB020713 Hs 56966 Hs 56966 KIAA0906 protem 246
417785 X59812 Hs 82568 NM.00 784 Homo sapiens cytochrome P450, 246
424673 AA345051 Hs 294092 Hs 294092 Homo sapiens mR full length in 246
422003 AA361760 Hs 296326 Hs 296326 ESTs, Weakly similar to A33533 246
432126 AA865239 Hs 37196 Hs 37196 putadve G protein coupled rxe 246
445937 AI452943 Hs 321231 NM.003779 Homo sapiens UDP-Gal betaGlcc 246
409354 N68188 Hs 159472 Hs 159472 Homo sapiens cD FU22224 fis, 246
401179 246
418151 AA864238 comp Hs 83583 NM.005731 Homo sapiens xdn related pro 245
422648 D86983 Hs 118893 Hs 118893 Melanoma assxiated gene 245
427759 BE245578 Hs 2200 NM.005041 Homo sapiens perfoπn 1 (prefo 245
431222 X56777 Hs 273790 NM.007155 Homo sapiens zo pellucida glyc 245
411529 AA430348 Hs 317596 Hs 317596 Homo sapiens cD FU 12927 fis, 245
426825 AL133415 Hs 297753 NM_003380 Homo sapiens vimentiπ (VIM) m 245
422242 AJ251760 Hs 273385 NMJ16592 Homo sapiens GS complex tocus 245
408105 AW152207 Hs 270977 Hs 270977 ESTs 244
426410 BE298446 Hs 305890 Hs 305890 BCL2-lιke 1 244
421064 AI245432 Hs 101382 NM_006291 Homo sapiens tumor nxrosis fa 244
428157 AI738719 Hs 198427 NM_000189 Homo sapiens hexokise 2 (HK2), 244
424398 BE397787 Hs 146393 NM_014685 Homo sapiens homxysteine-indu 244
424825 AF207069 Hs 153357 NM_0O1084 Homo sapiens procollagen-lysin 244
426031 AA295251 Hs 166066 Hs 166066 cisplatin resistance assxiate 243
409817 BE295464 Hs 56607 Hs 56607 Williams-Beuren syndrome chromo 243
429359 W00482 Hs 2399 NM.004995 Homo sapiens matπx metallopro 243
426761 AI015709 Hs 172089 Hs 172089 pro-oncosts rxeptor inducing 243
429332 AF030403 Hs 199263 NMJJ13233 Homo sapiens senne threonine 243
425923 NM 005026 Hs 162808 NM.005026 Homo sapiens phospho osidde- 243
432211 BE274530 Hs 273333 Hs 273333 hypothetical protein FU10986 243
433339 AF019226 Hs 8036 Hs 8036 RAB3D, member RAS oncogene famil 242
420539 AA282735 Hs 44004 Hs 44004 AD031 protein 242
413243 AA769266 Hs 193657 Hs 193657 ESTs 242
435029 AF167706 Hs 19280 Hs 19280 cysteme πch motor neuron 1 242
422374 AW732869 Hs 1519 Hs 1519 protein kise, cAMP-dependent, re 242
444501 AW247624 Hs 11342 NM.004148 Homo sapiens πmjuπn 1 (NINJ1 242
414919 AW087337 Hs 194461 Hs 194461 ESTs 242
419355 AA428520 Hs 90061 NM_006667 Homo sapiens progesterone rxe 242
436042 AF284422 Hs 119178 Hs 119178 cation-chloπde cotransporter- 242
418245 AA088767 Hs 83883 Hs 83883 transmembrane, prostate androge 242
444215 AB033075 Hs 10669 Hs 10669 development and differentiadon 241
408683 R58665 Hs 46847 NMJ16614 Homo sapiens TRAF and TNF rxe 241
423701 AA329856 Hs 143022 Hs 143022 ESTs 241 441783 BE313412 Hs 7961 Hs 7961 Homo sapiens clone 25012 mR sequ 241
428072 BE258602 Hs 182366 NM_016292 Homo sapiens heat sh∞k protei 241
434599 AB002313 Hs 3989 Hs 3989 plexm B2 240
442351 W52642 Hs 8261 Hs 8261 SPRY doman-contanmg SOCS box 240
407894 AJ278313 HS 41143 Hs 41143 phospholipase C beta 1 (phosph 240
453449 W16752 Hs 32981 Hs 32981 sema domain, immunoglobulin dom 240
408688 AI634522 Hs 152925 Hs 152925 KIAA1268 protein 240
422448 AW372922 Hs 116774 Hs 116774 integnn, alpha 1 239
416269 AA177138 Hs 161671 Hs 161671 ESTs 239
452679 Z42387 Hs 83883 Hs 83883 transmembrane, prostate androge 2 38
432981 NM 002733 Hs 3136 NM_ 02733 Homo sapiens protein kise, AMP 238
419846 NM 015977 Hs 285681 Hs 285681 Williams Beuren syndrome chrom 238
422110 AI376736 Hs 111779 Hs 111779 sxreted protein, xidic, cyst 238
413092 AA126856 Hs 118665 Hs 118665 ESTs 238
433969 AW207279 Hs 271786 Hs 271786 ESTs, Weakly simila to PC4395 237
451267 AI033894 Hs 117865 Hs 117865 solute earner family 17 (anio 237
447526 AL048753 Hs 303649 NM_002982 Homo sapiens small inducible c 2 37
441623 AA315805 Hs 348710 Hs 348710 Homo sapiens, done IMAGE 4242 237
420255 NM 007289 Hs 1298 NM.007289 Homo sapiens membrane metallo- 237
409274 NM 003930 Hs 52644 NM.003930 Homo sapiens src family ass∞i 236
422801 AF125672 Hs 287994 Hs 287994 nuclear rxeptor co-repressor 236
407887 AA579668 Hs 41072 Hs 41072 senne (or cysteine) proteise i 236
408212 AA297567 Hs 43728 NM.015696 Homo sapiens weakly simila to 236
430478 NM_014349 Hs 241535 NM.014349 Homo sapiens apolipoprotein L, 236
405102 235
423583 AL122055 Hs 129836 Hs 129836 KIAA1028 protein 235
426125 X87241 Hs 166994 NM.005245 Homo sapiens FAT tumor suppres 235
425204 NM_002436 Hs 1861 NM_002436 Homo sapiens membrane protein, 235
420676 AI434780 Hs 4248 Hs 4248 Homo sapiens PP3781 mR, complete 235
421079 AW404994 Hs 101695 Hs 101695 NCK adaptor protein 2 235
410039 AF207989 Hs 58014 Hs 58014 G protein-coupled rxeptor, fam 234
412958 BE391579 Hs 75087 NM.006712 Homo sapiens FAST kise (FASTK) 2 34
430363 M28713 Hs 274464 NM.000398 Homo sapiens diaphorase (DH) ( 234
425397 J04088 Hs 156346 NM_001067 Homo sapiens topoisomerase (D) 234
451035 AU076785 Hs 430 NM.002670 Homo sapiens plasdn 1 (I isof 234
449027 AJ271216 Hs 22880 Hs 22880 dipepddylpepddase III 234
429457 BE243065 Hs 202955 Hs 202955 hypothedcal protein FLJ20507 234
417709 D87434 Hs 82426 NM.014734 Homo sapiens KIAA0247 gene pro 234
412805 AW954569 Hs 278675 Hs 278675 bromodomaπ-containing 4 234
427647 W19744 Hs 180059 Hs 180059 Homo sapiens cD FLJ31360 fis, 234
430702 U56979 Hs 278568 NM.000186 Homo sapiens H fxtor 1 (compl 233
456804 AI421645 Hs 139851 NM.001233 Homo sapiens caveolin 2 (CAV2) 233
453648 W21493 Hs 28329 Hs 28329 protein phosphatase 1, regulato 2 33
450812 AB002360 Hs 25515 Hs 25515 MCF 2 cell line denved transfo 233
402575 233
424670 W61215 Hs 116651 NM.005797 Homo sapiens epithelial V-like 232
452960 AK001335 Hs 31137 NM.006504 Homo sapiens protein tyrosine 232
442968 AK000606 Hs 8868 NM.004871 Homo sapiens golgi SP rxeptor 232
410639 BE269047 Hs 65234 Hs 65234 DEAD/H (Asp-Glu-Ala-Asp/His) bo 232
415169 W42913 Hs 78089 NM.004231 Homo sapiens ATPase, H+ transp 232
450160 BE048099 Hs 183738 Hs 183738 FERM, RhoGEF (ARHGEF) and plec 2 32
407223 H96850 H96850 yw03b12 s1 Soares melanxyte 2NbH 232
426780 BE242284 Hs 172199 NM.001114 Homo sapiens adenylate cyclase 2 32
434987 AW975114 Hs 371677 Hs 371677 ESTs 232
416354 NM_000633 Hs 79241 NM.000633 Homo sapiens B-cell CLUlympho 231
453107 NM 016113 Hs 279746 NM.016113 Homo sapiens transient rxepto 2 31
422963 M79141 Hs 13234 Hs 13234 ESTs, Weakly similar to hypothe 231
433618 AA602539 Hs 345494 Hs 345494 ESTs, Moderately similar to ZN 231
438584 AA811347 AA811347 ob81h06 s1 NCI.CGAP.GCB1 Homo s 231
446126 AW085909 Hs 356618 Hs 356618 ESTs, Weakly simila to PC4259 231
408716 AI567839 Hs 151714 Hs 151714 peroxisomal proliferator-xdv 2 30
433230 AW136134 Hs 220277 Hs 220277 ESTs, Weakly simila to expres 230
410168 AW834O50 Hs 351432 Hs 351432 tensm 230
446342 BE298665 Hs 14846 Hs 14846 Homo sapiens mR, cD DKFZp564D01 230
418452 BE379749 Hs 85201 NM_005127Homo sapiens C-type (calcium d 230
453175 NM 006834 Hs 32217 NM_006834 Homo sapiens RAB32, member RAS 229
409012 AL117435 Hs 49725 Hs 49725 DKFZP434I216 protein 229
452848 AI417193 Hs 288912 Hs 288912-BBP-hke protein 2 2 29
418838 AW385224 Hs 35198 Hs 35198 xtonucl∞dde pyrophosphatase/ 229
422562 AI962060 Hs 118397 NM_001129 Homo sapiens AE binding protei 2 28
432828 AB042326 Hs 287402 Hs 287402 chondroidn 4-sulfotransferase 228
412948 BE243313 Hs 334851 NM_006148 Homo sapiens LIM and SH3 prote 228
426068 AF029778 Hs 166154 NM.002226 Homo sapiens jagged 2 (JAG2). 2 28
456919 NM_003900 Hs 182248 NM_00390 Homo sapiens sequestosome 1 (S 228
452806 AW014549 Hs 58373 Hs 58373 ESTs 2 28
453983 H94997 Hs 16450 Hs 16450 ESTs 228
407736 N41744 Hs 349326 Hs 349326 Homo sapiens cD FU30677 fis 228
413211 AW967107 Hs 109274 Hs 109274 hypothedcal protein MGC4365 2 28
422051 AW327546 Hs 111024 Hs 111024 solute earner family 25 (mito 227
438438 AA257992 Hs 50651 Hs 50651 Janus kise 1 (a protein tyrosm 227
436278 BE396290 Hs 5097 NM_004710 Homo sapiens syptogyπn 2 (SYN 2 27
454080 AI199711 Hs 576 NM_O00147 Homo sapiens fucosidase, alpha 2 27
426542 AF190746 Hs 170310 NM_017424 Homo sapiens cat eye syndrome 227 417115 AW952792 Hs 334612 2 27
402901 226
412898 AI129903 Hs 74669 NM.006634 Homo sapiens vesicle-associate 2 26
413020 R98736 R98736 yr31h09 r1 Soares fetal liver spl 226
413939 AL047051 Hs 199961 Hs 199961 ESTs, Weakly similar to hypoth 2 26
408681 AW953853 Hs 281462 Hs 281462 hypothedcal protein FU14251 2 25
412330 NM 005100 HS 788 NM.0O5100 Homo sapiens A kise (PRKA) anc 225
442083 R50192 Hs 165062 Hs 165062 ESTs 2 25
418271 NM_000919 Hs 83920 NM.000919 Homo sapiens pepddylglycine a 2 25
433376 AI249361 Hs 74122 NM_001225 Homo sapiens caspase 4, apopto 225
438562 AI566826 Hs 25890 Hs 25890 ESTs, Weakly similar to transdu 225
443883 AA114212 Hs 9930 NM_001235 Homo sapiens senne (or cystei 2 25
416976 BE243985 Hs 80680 Hs 80680 major vault protein 224
416914 AA344481 Hs 80426 Hs 80426 brain and reproducdve organ-ex 224
400288 X06256 Hs 149609 NM.002205 Homo sapiens integnn, alpha 5 2 24
407904 W44735 Hs 107260 Hs 107260 putadve UDP-Galc polypepdde 224
429690 AW956329 Hs 23721 Hs 23721 ESTs 224
443813 AA876372 Hs 93961 Hs 93961 Homo sapiens mR, cD DKFZp667D09 2 24
427458 BE208364 Hs 29283 Hs 29283 ESTs, Weakly simila to LKHU pr 224
454294 AB000734 Hs 50640 NM.003745 Homo sapiens JAK binding prote 224
407192 AA609200 Hs 366318 Hs 366318 ESTs 223
425751 T19239 Hs 1940 NM 001885 Homo sapiens ciγstallm, alpha 223
456437 AI924228 Hs 115185 Hs U5185 ESTs 223
413019 BE281604 Hs 75140 NM_002337 Homo sapiens low density lipop 223
418862 BE550964 Hs 89399 Hs 89399 ATP synthase, H+ transporting, 223
435284 AA879470 Hs 96849 Hs 96849 Homo sapiens cD FU11492fis, c 223
429630 M85289 Hs 211573 NM_005529 Homo sapiens heparan sulfate p 2 23
427609 AK000436 Hs 179791 Hs 179791 RAB20, member RAS oncogene fam 2 23
421917 AB028943 Hs 109445 Hs 109445 hypermethylated in cancer 2 223
446616 R65964 Hs 334873 Hs 334873 caboxypepddase M 223
407232 X04526 X04526 Human liver mR for beta-subunit s 2 23
423798 AF047033 Hs 132904 Hs 132904 solute earner family 4, sodiu 223
446755 AW451473 Hs 16134 NM_005990 Homo sapiens seπnefthreonine 2 22
452865 AI924046 Hs 119567 Hs 119567 ESTs, Weakly similar to ALU1_H 2 22
431393 AW971493 Hs 134269 Hs 134269 ESTs, Weakly simila to 200439 222
431890 X17033 Hs 271986 NM J02203 Homo sapiens integnn, alpha 2 2 22
428782 X12830 Hs 193400 NM.000565 Homo sapiens terteukm 6 rx 222
446006 NM_004403 Hs 13530 NM.004403 Homo sapiens deafness, autosom 222
436418 AJ245874 Hs 4245 Hs 4245 chromosome 11 hypothedcal prote 222
423869 BE409301 Hs 134012 NM.006688 Homo sapiens C1q-related fxto 221
437730 AW071087 Hs 239176 Hs 239176 insulin-like growth fxtor 1 r 221
444020 R92962 Hs 35052 Hs 35052 ESTs 221
413882 AA132973 Hs 184492 Hs 184492 Homo sapiens mR, cD DKFZp667B0 221
412654 AI093480 Hs 374319 Hs 374319 ESTs 221
448988 Y09763 Hs 22785 NM_004961 Homo sapiens gamma-ammobutyπ 221
426841 AI052358 Hs 131741 Hs 131741 ESTs 221
408196 AL034548 Hs 43627 NM_006943 Homo sapiens SRY (sex determin 221
451711 AK000461 Hs 26890 Hs 26890 cat eye syndrome chromosome reg 220
414325 AA251929 Hs 355341 Hs 355341 Homo sapiens, clone IMAGE 3536 220
424512 X53002 Hs 149846 NM.002213 Homo sapiens integnn beta 5 220
448883 BE614989 Hs 7503 Hs 7503 hypothetical protein FU14153 220
411296 BE207307 Hs 10114 Hs 10114 growth suppressor 1 2 20
452268 NM_003512 Hs 28777 NM_003512Homo sapiens H2A histone famil 220
416810 AF035606 Hs 80019 NM.013232 Homo sapiens programmed ceil d 220
441415 H21497 Hs 7471 Hs 7471 BBP-like protein 1 220
444212 AW503976 Hs 10649 NM.004848 Homo sapiens basement membrane 2 19
428044 AA093322 Hs 301404 NM_006743 Homo sapiens R binding motif p 2 19
430017 AA263172 Hs 35 NM_002832 Homo sapiens protein tyrosine 2 19
424490 AJ278016 Hs 55565 Hs 55565 ankyπn repeat domain 3 2 19
431193 AW749505 Hs 296770 Hs 296770 KIAA1719 protein 2 19
453686 AL110326 Hs 304679 Hs 304679 ESTs. Weakly similar to Z195_H 2 19
448262 AW880830 Hs 186273 Hs 186273 ESTs 2 19
416065 BE267931 Hs 78996 NM_002592 Homo sapiens proliferating cel 2 19
442045 C05768 Hs 8078 Hs 8078 Homo sapiens clone FBD3 Cn-du-c 2 19
423804 AW403448 Hs 1706 NM_006084 Homo sapiens mterferon-sdmul 2 19
428024 Z29067 Hs 2236 Hs 2236 NIMA (never in mitosis gene a)-r 2 19
424503 NM 002205 Hs 149609 NM_002205 Homo sapiens integnn, alpha 5 2 19
437696 Z83844 Hs 5790 Hs 5790 hypothetical protein dJ37E165 2 18
405204 2 18
426158 NM.001982 Hs 199067 NM_001982 Homo sapiens v-erb-b2 erythrob 2 18
417418 NM 002468 Hs 82116 NM_0O2468 Homo sapiens myeloid different 2 18
412773 H15785 Hs 74573 NM.012268 Homo sapiens similar to vaxm 2 18
409402 AF208234 Hs 695 NM.000100 Homo sapiens cystadn B (stefi 2 18
443791 N64458 Hs 143345 Hs 143345 ESTs 2 18
435049 AL122067 Hs 4746 Hs 4746 hypothedcal protein FU21324 2 18
418389 AA830613 Hs 293849 Hs 293849 ESTs 2 18
450712 AI732130 Hs 270496 Hs 270496 ESTs, Weakly simila to ALUB_H 2 18
422007 AI739435 Hs 39168 Hs 39168 ESTs Weakly simila to T17340 2 18
453676 AW853745 Hs 286035 Hs 286035 hypothedcal protein FU22686 2 18
415718 F30631 Hs 200237 Hs 200237 ESTs 2 18
452688 AA721140 Hs 49930 Hs 49930 ESTs. Weakly similar to B34087 2 18
415988 BE407713 Hs 78943 NM_0O0386 Homo sapiens bleomyc hydrola 2 18
409453 AI885516 Hs 95612 Hs 95612 ESTs 2 17 417512 X76534 Hs 82226 NM_002510 Homo sapiens glycoprotein (tra 2 17
427202 BE272922 Hs 173936 NM_000628 Homo sapiens interieukin 10 re 2 17
440983 M20681 Hs 7594 NM.006931 Homo sapiens solute earner fa 2 17
416084 L16991 Hs 79006 NM_012145 Homo sapiens deoxythymidylate 2 17
429642 X68264 Hs 211579 NM_006500 Homo sapiens melanoma adhesion 2 17
427213 AW007211 Hs 348389 Hs 348389 hypothedcal protein FU12876 2 17
437763 AA469369 Hs 5831 NM.003254 Homo sapiens dssue inhibitor 2 17
454000 AA040620 Hs 5672 Hs 5672 golgi membrane protein SB 140 2 17
424247 X14008 Hs 234734 NM_000239 Homo sapiens lysozyme (rel amy 2 16
403857 2 16
406648 AA563730 Hs 277477 2 16
400265 2 16
442379 NM 004613 Hs8265 NM_004613 Homo sapiens fransglutamise 2 2 16
441892 AB028981 Hs 8021 Hs 8021 KIAA1058 protein 2 16
417446 AU 18671 Hs 82163 NM_000898 Homo sapiens monoamine oxidase 2 16
418386 AA361739 Hs 84549 NM J02494 Homo sapiens DH dehydrogese (u 2 16
414053 BE391635 Hs 75725 NM.003564 Homo sapiens transgelm 2 (TAG 2 16
440906 AW161556 Hs 240170 Hs 240170 hypothedcal protein MGC2731 2 16
447660 AW160386 Hs 163667 Hs 163667 ESTs, Weakly simila to CA1H_H 2 16
408279 AF216965 Hs 44095 Hs 44095 cyclιn M3 2 16
426152 BE299190 Hs 167246 Hs 167246 P450 (cytxhrome) oxidoreducta 2 16
437952 D63209 Hs5944 NM_014585 Homo sapiens solute earner fa 2 16
415661 AF057307 Hs 78575 Hs 78575 prosaposin (vanant Gaudier dis 2 15
425302 U79115 Hs 155566 NM_003805 Homo sapiens CASP2 and RIPK1 d 2 15
425996 W67330 Hs 374451 Hs 374451 ESTs 2 15
413745 AW247252 Hs 75514 NM_000270 Homo sapiens nucleoside phosph 2 15
422070 AF149785 Hs 111126 Hs 111126 pituitary tumor-transforming 1 2 15
448424 AW009892 Hs 31924 Hs 31924 ESTs 2 15
430035 NM 003463 Hs 227777 NM_003463 Homo sapiens protein tyrosine 2 15
438407 AI457122 Hs 129673 Hs 129673 eukaryodc translation initial 2 15
435551 AF212365 Hs 5470 Hs 5470 interieukin 17B receptor 2 15
437741 BE561610 Hs 5809 Hs 5809 putadve transmembrane protein, 2 15
441192 AA526626 Hs 7736 NM_016504 Homo sapiens mitxhondπal πb 2 15
435750 AB029012 Hs 4990 Hs 4990 KIAA1089 protein 2 15
411165 NM 000169 Hs 69089 NM_000169 Homo sapiens galxtosidase, al 2 14
425252 AW391162 Hs 349306 Hs 349306 hypothedcal protein FU31951 2 14
427600 AW630918 Hs 179774 NM.002818 Homo sapiens proteasome (proso 2 14
426818 AA554827 Hs 292996 Hs 292996 post eiodc segregadon increa 2 14
442110 AF113008 Hs8102 NM.001023 Homo sapiens πbosomal protein 2 14
407797 AK000524 Hs 39850 "" Hs 39850 undine kise-like 1 2 14
443044 N28522 Hs 8935 NM_014298 Homo sapiens quinolite phospho 2 14
437103 AW139408 Hs 152940 Hs 152940 ESTs 2 14
442069 AW664144 Hs 297007 Hs 297007 Homo sapiens cD FU32174 fis, 2 14
424954 NM 000546 Hs 1846 NM_000546 Homo sapiens tumor protein p53 2 14
458097 AW341135 Hs 58104 Hs 58104 Homo sapiens, clone IMAGE 47309 2 14
411925 AW014588 Hs 72925 NM_003475 Homo sapiens chromosome 11 ope 2 14
449644 AW960707 Hs 148324 Hs 148324 ESTs 2 14
422675 BE018517 Hs 119140 NM_001970 Homo sapiens eukaryotic transl 2 14
428586 M36712 Hs 2299 Hs 2299 CD8 andgen, beta polypepdde 1 2 14
429379 NM 014840 Hs 200598 NM_014840 Homo sapiens KIAA0537 gene pro 2 13
410290 AA402307 Hs 322844 Hs 322844 hypothetical protein DKFZp564A 2 13
443895 AW979048 Hs 292566 Hs 292566 YEA4 protein 2 13
428145 BE243327 Hs 182626 NM.012264 Homo sapiens chromosome 22 ope 2 13
453518 AW503205 Hs 27268 Hs 27268 Homo sapiens cD FLJ21933 fis, 2 13
456534 X91195 Hs 100623 Hs 100623 protein phosphatase 1, regulat 2 13
419972 AL041465 Hs 182982 Hs 182982 gdgιn-67 2 13
424950 AA602917 Hs 156974 Hs 156974 ESTs 2 13
427557 NM 002659 Hs 179657 NM.002659 Homo sapiens plasminogen xdv 2 13
431449 M55994 Hs 256278 NM_O01066 Homo sapiens tumor nxrosis fa 2 13
418758 AW959311 Hs 172012 Hs 172012 hypothetical protein DKFZp434J 2 13
434202 BE382411 Hs 3764 NM.000858 Homo sapiens guanylate kise 1 2 13
433233 AB040927 Hs 301804 Hs 301804 KIAA1494 protein 2 12
452700 AI859390 Hs 288940 Hs 288940 transmembrane protein 8 (five 2 12
438033 T26483 Hs 6059 NM_016938 Homo sapiens EGF-contanmg fi 2 12
400847 2 12
447547 NM 007229 Hs 18842 NM_007229 Homo sapiens protein kise C an 2 12
417052 NM 000712 Hs 81029 NM_O00712 Homo sapiens biliverdin reduct 2 12
413284 AU077055 Hs 289107 NM_001166 Homo sapiens bxuloviral IAP r 2 11
434558 AW264102 Hs 39168 Hs 39168 ESTs, Weakly similar to T17340 2 11
404030 2 11
410801 BE275469 Hs 66493 Hs 66493 Down syndrome cπdcal region g 2 11
418613 AA744529 Hs 86575 Hs 86575 mitogen-xdvated protein kise 2 11
447087 AW403870 Hs 301872 Hs 301872hypothedcal protein MGC4840 2 11
433026 AW160616 Hs 279921 NM.016127 Homo sapiens hypothedcal prot 2 11
426433 L38969 Hs 169875 NM.007112 Homo sapiens thrombospondin 3 2 11
442439 U09759 Hs 246857 NM.002752 Homo sapiens mitogen-xdvated 2 11
437379 AL359575 Hs 23765 Hs 23765 membrane metallo-endopeptidase- 2 11
400208 2 11
455705 AW161061 Hs 356580 Hs 356580 ESTs, Weakly simila to zinc f 2 11
417599 AA204688 Hs 62954 Hs 62954 femdn, heavy polypepdde 1 2 10
416728 AB024597 Hs 79658 NM.001894 Homo sapiens casein kise 1, ep 2 10
439920 H05430 Hs 288433 Hs 288433 neurotπmin 2 10
422309 U79745 Hs 114924 NM.004694 Homo sapiens solute earner fa 2 10 436114 AA778232 Hs 19515 Hs 19515 ESTs Highly similar to NRG3.HU 2 10
405517 2 10
421872 AA359753 Hs 22824 Hs 22824 MYB binding protein (P160) 1a 2 10
437712 X04588 Hs 85844 Hs 85844 neurotrophic tyrosine kise, rx 210
431214 AA294921 Hs 348024 NM.002881 Homo sapiens v-ral simian leuk 2 10
412856 BE386745 Hs 74631 NM_001728 Homo sapiens basigm (BSG), mR 2 10
442064 AI422867 Hs 88594 Hs 88594 Homo sapiens, clone IMAGE 43329 210
434845 BE267057 Hs 325321 Hs 325321 WD repeat domain 18 210
426728 NM 007118 Hs 367689 NM_007118 Homo sapiens tuple funcdol d 2 10
419596 BE379320 Hs 91448 NM_007O26 Homo sapiens dual spxificity 209
448913 AA194422 Hs 22564 NM.004999 Homo sapiens myosin VI (MY06), 209
414721 X90392 Hs 77091 NM.006730 Homo sapiens deoxyπbonuclease 209
424658 NM 002406 Hs 151513 NM.002406 Homo sapiens mannosyl (alpha-1 209
432805 X94630 Hs 3107 Hs 3107 CD97 andgen 209
447032 AK000310 Hs 17138 Hs 17138 hypothedcal protein FU20303 209
447484 AA464839 Hs 292566 Hs 292566 YEA4 protein 209
440188 AK001812 HS 7036 Hs 7036 N-acetylglucosamine kise 209
445584 AF217518 Hs 8360 Hs 8360 PTD012 protein 209
402559 209
418043 AW377752 Hs 83341 Hs 83341 AXL rxeptor tyrosine kise 209
448888 AW196663 Hs 200242 Hs 200242 caspase recruitment domain fam 209
436910 AA926944 Hs 261587 Hs 261587 GCN2 elF2alpha kise 209
422573 AW297985 Hs 295726 Hs 295726 integnn, alpha V (vitronxdn 208
416448 L13210 Hs 79339 NM.005567 Homo sapiens Ixdn, galxtosi 208
428727 AF078847 Hs 191356 NM_O01515 Homo sapiens general transcπp 208
410301 AW502935 Hs 740 Hs 740 PTK2 protein tyrosine kise 2 208
449538 AI559444 Hs 104679 Hs 104679 Homo sapiens, clone MGC 18216 208
421205 AL137540 Hs 102541 Hs 102541 netπn 4 208
411779 AA292811 Hs 72050 NM 003551 Homo sapiens non-metastadc ce 208
427704 AW971063 Hs 292882 Hs 292882 ESTs 207
413518 BE149455 Hs 75415 NM_004048 Homo sapiens beta-2-mιcroglobu 207
447345 BE247767 Hs 18166 Hs 18166 KIAA0870 protein 207
407143 C14076 Hs 332329 Hs 332329 EST 207
448431 BE613061 Hs 337772 Hs 337772 hypothedcal protein BC009331 207
412760 AW379030 Hs 41324 Hs 41324 ESTs 207
446859 AI494299 Hs 16297 NM_005694 Homo sapiens COX17 homolog. cy 207
403966 207
409115 AI223335 Hs 50651 NM_002227 Homo sapiens Janus kise 1 (a p 207
436823 AW749865 Hs 117077 Hs 117077 zinc finger protein 264 207
414045 NM 002951 Hs 75722 NM.002951 Homo sapiens πbophoπn II (RP 206
413980 NM 002437 Hs 75659 NM.0 2437 Homo sapiens MpV17 transgene, 206
439414 NM 001183 Hs 6551 NM_001183 Homo sapiens ATPase, H+ transp 206
426059 BE292842 Hs 166120 NM_001572 Homo sapiens interferon regula 206
429849 U33053 Hs 2499 NM_002741 Homo sapiens protein kise C-li 206
402424 206
406626 X04526 Hs 215595 Hs 215595 guanine nucl∞dde binding pro 206
458911 AA373131 Hs 24322 Hs 24322 ATPase, H+ transporting, lysoso 205
426086 T94907 Hs 188572 Hs 188572 ESTs 205
419726 U50330 Hs 1274 NM_0061 9 Homo sapiens bone morphogeneti 205
452344 AI264357 Hs 55405 Hs 55405 hypothedcal protein MGC16212 205
442498 U54617 Hs 8364 NM_002612 Homo sapiens pyruvate dehydrog 205
422114 AW194851 Hs 111801 NM_015908 Homo sapiens arsete resistance 205
413420 AW410235 Hs 75348 NM.006263 Homo sapiens proteasome (proso 205
409430 R21945 Hs 346735 Hs 346735 Homo sapiens, clone IMAGE 3881 205
409932 AI376750 Hs 57600 Hs 57600 adaptor-related protein complex 205
434848 BE256304 Hs 32148 Hs 32148 AD-015 protein 204
453852 AW961818 Hs 374424 Hs 374424 ESTs 204
427637 AK000816 Hs 179986 NM.005803 Homo sapiens flodllin 1 (FLOT 204
400264 204
430016 NM 004736 Hs 227656 NM_004736 Homo sapiens xenotropic and po 204
410134 U68140 Hs 58927 Hs 58927 nuclear VCP-like 204
440975 AW499914 Hs 7579 Hs 7579 importm 9 204
432280 BE440142 Hs 2943 NM_003135 Homo sapiens sigl recognidon 204
409504 AA304961 Hs 699 NM_000942 Homo sapiens pepddylprolyl is 204
412146 M92444 Hs 73722 NMJ301641 Homo sapiens APEX nuclease (mu 204
434203 BE262677 Hs 283558 Hs 283558 hypothetical protein PR01855 204
422754 AA316476 Hs 171811 Hs 171811 adenylate kise 2 204
406729 AA069711 AA069711 zm52b11 s1 Stratagene fibroblas 204
413086 AA126841 Hs 183834 Hs 183834 ESTs 203
424340 AA339036 Hs 7033 Hs 7033 ESTs 203
450440 AB024334 Hs 25001 NM_012479 Homo sapiens tyrosine 3-monoox 203
424662 NM 002870 Hs 151536 NM_002870 Homo sapiens RAB13, member RAS 203
415740 N80486 Hs 39911 Hs 39911 Homo sapiens mR for FU0 089 pr 203
412749 AA378417 Hs 74564 NM.003145 Homo sapiens sigl sequence rx 203
408393 AW015318 Hs 23165 Hs 23165 ESTs 203
421295 AW081061 Hs 103180 Hs 103180 DC2 protein 203
445417 AK001058 Hs 12680 Hs 12680 Homo sapiens cD FLJ10196 fis. c 203
414883 AA926960 Hs 348669 NM_001826 Homo sapiens CDC28 protein kis 203
447298 BE617527 Hs 239818 Hs 239818 phosphomosιtιde-3-kιse, catal 202
459580 AA022888 Hs 176065 Hs 176065 ESTs 202
422785 AI824114 Hs 289088 Hs 289088 heat slrock 90kD protein 1, alp 202
452696 AI826645 Hs 211534 Hs 211534 Homo sapiens cD FU31665 fis, 202
452056 AW955065 Hs 101150 Hs 101150 KIAA1949 protein 202 450690 AA296696 Hs 333418 NM_014164 Homo sapiens FXYD doman-conta 202
423527 AI206965 Hs 105861 Hs 105861 engulfment and cell modlity 3 201
429545 AI824164 Hs 356130 Hs 356130 ESTs 201
439180 AI393742 Hs 199067 Hs 199067 v-erb-b2 erγthroblasdc leukem 201
437193 8E259190 Hs 289721 Hs 289721 growth arτest-spxιfic 5 201
436014 AF281134 Hs 283741 Hs 283741 exosome component Rrp46 201
453329 T97205 Hs 193400 Hs 193400 interieukin 6 receptor 201
407347 AA829847 T23514 seq3329 1-NIB Homo sapiens cD do 201
435370 AI964074 Hs 225838 Hs 225838 ESTs 201
430657 AA482910 Hs 370602 Hs 370602-ESTs, Weakly similar to hypoth 201
427157 U51166 Hs 173824 NM_003211 Homo sapiens thymine-D glycosy 201
424833 NM 003894 Hs 153405 NM.003894 Homo sapiens penod homolog 2 201
440086 NM 005402 Hs 6906 NM_005402Ηomo sapiens v-ral simian leuk 201
438543 AA810141 Hs 192182 Hs 192182 ESTs 201
417426 NM 002291 Hs 82124 NM_002291 Homo sapiens laminin, beta 1 ( 201
412790 NM_014767 Hs 74583 NM_014767 Homo sapiens KIAA0275 gene pro 201
445892 AV65550O Hs 93961 Hs 93961 Homo sapiens R, cD DKFZp667D09 201
TABLE 39B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank a∞ession numbers
Pkey CAT Number Accession 409745 MH1944_5 BI030997 AA921874 AW188822 B1027862 AI347618 AI361453 AI088754 AW207491 AA077391 BG012775 BG997382 AA286833 AA150722 BI007625
BI027864 BI009100 BI006275 BI006270 BI031000 BI029864 BI006277 BI007627 BI006266 BI006991 BI006990 BI007763 BI007762 BG997377
AA150780 BI033518 BI027818 BG015789 BI033807 AA341445
418869 12789J4 AA229762 AA230035 421902 276321.1 BG171436 BE079601 BE079534 AA299964 BE392717 BE883402 BE079532 BE018148 BF889427 W00396 400231 MH494.5 BC013310 AF261085 BC004109 AY007133 BC009081 BC001601 NM.002046 M33197 BC020308 J02642 M36164 BE794233 AV721080 BE255459
BG926429 BG389312 BG477333 AI031799 BI763443 BI260432 AA989106 AV728576 BI091380 AA402499 AI200513 AI284734 AI223995 AI289749
BG283291 BM013814 AW438544 BM450203 F35435 F33262 BE890952 AA401181 BG939668 F35525 BI088182 F34674 F33506 BM471326 F34677
AW276712AA187508 F34866 AA114245AA522581 N23935 AI076923 AI018505 BE879774 BM465637 AI753078 BG222159 AA5959478F970917
BI094125 AA719841 BE893087 BG775178 BE793983 BE797071 BF339134 BE409272 BE266456 BE796770 BE745957 BG755835 BE266758
BE259342 BM450181 BG748174 BE299322 BM423587 BM467637 BM452667 BM479516 BM452420 BE273297 BM466364 BM450640 BM478743
BM459094 BM455306 BM472001 BM478247 BM478771 BM480379 BM459071 BM450106 BM467584 BM464548 BM465044 BM450176 BF569359
BM462924 BM455329 BM471815 BI862301 BG331736 H04903 AA374894 BE902964
438584 1241536.1 AW977949 AA811347 D79715 413020 1485885.1 BE048113 R98736 Z42904 400265 11451 X58141 NM.001119 AI246786 BE645243 AI685698 AI208590 BE222576 AI191715 AI423108 BF064068 BG057819 AI208589 AI880535 AI262890
AI246261 BF939926 AI282848 AI802409 BE301053 AI884624 AI160385 AI335983 BF440017 BG231884 AI343699 Al 280745 AI871338 AI123739
AI871126 AW080375 AI350160 AI300855 AI818598 AI085263 AI306653 AW571658 BF109839 AW273280 AI888380 AI571860 AI357126 AW194105
Al 131474 AW316548 AW128942 AW571682 AI583962 AW300674 BF509394 AI891077 BF221538 AI651874 F25731 AW881176 AI685962 D44936
AI753874 BF593905 BE832830 AI637970 BE834103 BE464301 AI908017 AI378261 AA975416 R16732 H47612 H45402 AA668719 AA722441
AA991443 T51951 AW514058 AI277763 AA421907 AI083831 H40630 NM 014190 BM469282 AL524786 AL527067 BF313768 AL042441 AL037806
BI195013 BE219292 BF055534 T95785 BE833037 AV648052 AA382588 W67987 H46049 R92289 H47699 AA380016 AL532433 BG958742 AI292151
H26003 R62487 BG766512 BE815124 AW136122 H96767 R39407 BI044500 H18771 H22071 R09985 R75803 H42172 BE770251 AL529310 F03180
R92185 H18680 R43192 AA401390 AA977941 AI091944 AA993369 AA617840 H14351 AI866242 AI915028 AA780787 AA506995 AA827496 AA634305
AA846358 AA470463 AA618163 AA601963 W74212 AA021520 AA421274 AA903521 AA411402 AA044448 AA983449 AA076114 AA633470 AA581793
AA019060 AA814222 AA693469 N99931 N67840 R26834 BF342340 AA976636 AA360268 AA976223 T95786 AA527774 AI620298 AA180888
AA149218 AA565201 BI001597 BE676565 AW169797 AW190994 AA299572 AI092819 AI291438 AA459586 AA136373 R50213 BE622752 AA401414
AA180973 AA766800 W96432 BI550308 H52236 AA491029 BG420468 BG827522
400208 16640.1 X78817 NM.001666 D50921 AW002308 AW575456 BF507511 AW467767 AI910663 BF905778 BG251264 AL562106 AI890538 AW769258 AI590391
AI913055 AW083235 AI078474 AI925022 AW504628 AW 129725 BE466589 AW002786 AW591760 AI968816 AW006268 AW593787 BG236814
AW769893 AW407608 AW075982 AI248207 AI762509 AI812070 AI249937 AW083561 AW080697 BF663046 BG745612 BG979546 AW793245
BI014177 AL519126 BE675314 AW806520 BI870778 BF879549 BE714919 BF847786 BG684161 AV695278 BG491029 BE793244 BE830893
BE798121 09703 BI013066
400264 1145.1 X58141 NM_001119 AI246786 BE645243 AI685698 AI208590 BE222576 AI191715 AI423108 BF064068 BG057819 AI208589 AI880535 AI262890
AI246261 BF939926 AI282848 AI802409 BE301053 AI884624 AI160385 AI335983 BF440017 BG231884 AI343699 AI280745 AI871338 AI123739
AI871126 AW080375 AI350160 AI300855 AI818598 AI085263 AI306653 AW571658 BF109839 AW273280 AI888380 AI571860 AI357126 AW194105
AI131474 AW316548 AW128942 AW571682 AI583962 AW300674 BF509394 AI891077 BF221538 AI651874 F25731 AW881176 AI685962 D44936
AI753874 BF593905 BE832830 AI637970 BE834103 BE464301 AI908017 AI378261 AA975416 R16732 H47612 H45402 AA668719 AA722441
AA991443T51951 AW514058 AI277763 AA421907 AI083831 H40630 NM_014190 BM469282AL524786 AL527067 BF313768 AL042441 AL037806
BI195013 BE219292 BF055534 T95785 BE833037 AV648052 AA382588 W67987 H46049 R92289 H47699 AA380016 AL532433 BG958742 AI292151
H26003 R62487 BG766512 BE815124 AW136122 H96767 R39407 BI044500 H18771 H22071 R09985 R75803 H42172 BE770251 AL529310 F03180
R92185 H18680 R43192 AA401390AA977941 AI091944 AA993369 AA617840 H14351 AI866242AI915028 AA780787AA506995 AA827496 AA634305
AA846358 AA470463 AA618163 AA601963 W74212 AA021520 AA421274 AA903521 AA411402 AA044448 AA983449 AA076114 AA633470 AA581793
AA019060 AA814222 AA693469 N99931 N67840 R26834 BF342340 AA976636 AA360268 AA976223 T95786 AA527774 AI620298 AA180888
AA149218 AA565201 BI001597 BE676565 AW169797 AW190994 AA299572 AI092819 AI291438 AA459586 AA136373 R50213 BE622752 AA401414
AA180973 AA766800 W96432 BI550308 H52236 AA491029 BG420468 BG827522
406729 0.0 AA069711 407347 810943.1 T23514 AI655785
TABLE 39C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al * refers to the publication endtled The DNA sequence of human chromosome 22* Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposidon Indicates nudxtide positions of predicted exons
Pkey Ref Strand Nt position
404240 5002624 Minus 116132-116407,116653-116922
404277 1834458 Minus 9166591946 401179 9438647 Plus 113477-113893
405102 8076881 Minus 120922-121296
402575 9884830 Minus 109742-109883
402901 8894222 Minus 175426-175667
405204 7230116 Plus 126569-126754
403857 7708910 Minus 2524-3408
400847 9188605 Plus 44643-44835
404030 7671252 Plus 149362-151749
405517 9454624 Plus 114757-114877
402559 9864273 Plus 33539-33715
403966 8568881 Plus 158193-158277,160116-160290
402424 9796344 Minus 64925-65073
TABLE 40A ABOUT 977 GENES UP-REGULATED IN STOMACH CANCER
Table 40A lists about 977 genes up-regulated in stomxh cancer compaed to normal adult dssues These were selxted from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the ratio of 'average* stomxh cancer to "average" normal adult dssues was greater than or equal to 20 The "average" stomxh cancer level was set to the 90th percendle amongst vanous stomxh cancers The "average* normal adult dssue level was set to the 90th percendle amongst vanous non-malignant dssues In order to remove gene-spxific bxkground levels of non-spxific hybπdizadon, the 15th percendle value amongst vanous non-malignant dssues was subtrxted from both the numerator and the denominator before the ratio was evaluated
Pkey Unique Eos probeset identifier number
ExAccn , Exemplar Accession number, Genbank accession number
UnigenelD Unigene number
Unigene Tide. Unigene gene dde
R1 Rado of tumor to normal adult dssues
Pkey ExAccn UnigenelD Unigene Tide R1
411243 AB039886 Hs 69319 CA11 3066
418007 M13509 Hs 83169 matrix metalloproteinase 1 (interstitial 1694
444325 AW152618 Hs 16757 ESTs 13 51
445891 AW391342 Hs 199460 ESTs 11 92
448811 AI590371 Hs 174759 ESTs 11 08
431723 AW058350 Hs 16762 Homo sapiens mRNA, cDNA DKFZp564B2062 (f 1084
409757 NM_001898 Hs 123114 cystadn SN 1038
421110 AJ250717 Hs 1355 cathepsin E 911
428368 BE440042 Hs 83326 matπx metalloproteinase 3 (stromelysm 866
446998 N99013 Hs 16762 Homo sapiens mRNA cONA DKFZp564B2062 (f 850
406687 M31126 Hs 272620 pregnancy spxific beta-1-glycoproteιn 9 7 11
428651 AF196478 Hs 188401 annexin A10 686
425211 M18667 Hs 1867 progastncsin (pepsmogen C) 651
423673 BE003054 Hs 1695 matnx metalloproteinase 12 (mxrophage 649
409683 U33317 Hs 711 defensin, alpha 6, Paneth cell-spxific 639
422260 AA315993 Hs 105484 ESTs, Weakly similar to UTB.HUMAN LITHO 631
428664 AK001666 Hs 189095 similar to SALL1 (sal (Drosophila) like 625
409041 AB033025 Hs 50081 KIAA1199 protein 572
408380 AF123050 Hs 44532 diubiquidn 572
428953 AA306610 Hs 194676 DKFZP434C013 protein 546
450685 L15533 Hs 423 pancreatitis-associated protein 540
409187 AF154830 Hs 50966 carbamoyl phosphate synthetase 1, mitoch 534
434206 AW136973 Hs 288516 ESTs, Weakly similar to S69890 mitogen i 516
421346 Z34277 Hs 103707 apomucm 5 14
427585 D31152 Hs 179729 collagen, type X, alpha 1 (Sch id metaph 506
425679 X05997 Hs 159177 lipase, gastπc 494
421582 AI910275 Hs 1406 trefoil fxtor 1 (breast cancer, estroge 493
434414 AI798376 gb tr34b07 x1 NCI_CGAP_O 23 Homo sapiens 492
422956 BE545072 Hs 122579 hypothedcal protein FU10461 489
448105 AW591433 Hs 170675 ESTs, Weakly similar to TMS2_HUMAN TRANS 484
423575 C18863 Hs 163443 Homo sapiens cDN A FU 11576 fis, clone HE 472
413385 M34455 Hs 840 indoleamine-pyrrole 2,3 dioxygenase 472
417866 AW067903 Hs 82772 collagen, type XI, alpha 1 468
448693 AW004854 Hs 228320 Homo sapiens cDNA FU23537 fis, clone L 453
441377 BE218239 Hs 202656 ESTs 4 51
419278 AU076799 Hs 1247 apolipoprotein A-IV 448
407811 AW190902 Hs 40098 cysteine knot superfamily 1, BMP antagon 447
403422 438
403776 432
418478 U38945 Hs 1174 cyclm-dependent kinase inhibitor 2A (me 432
428242 H55709 Hs 2250 leukemia inhibitory fxtor (cholmergic 430
421341 AJ243212 Hs 279611 deleted in malignant brain tumors 1 430
451181 AI796330 Hs 207461 ESTs 4 26
432168 AK000563 Hs 272805 hypothetical protein FLJ20556 423
454464 AW811606 Hs 271819 Homo sapiens cDNA FLJ22751 fis clone K 420
448844 AI581519 Hs 177164 ESTs 414
428434 AW363590 Hs 65551 ESTs, Weakly similar to AF172993 1 PLUNC 413
452461 N78223 Hs 108106 transcnpdon fxtor 408
409420 Z15008 Hs 54451 laminin, gamma 2 (nicem (100kD) kalini 404
431611 U58766 Hs 264428 dssue spxific transplantation antigen 404
413719 BE439580 Hs 75498 small inducible cytokine subfamily A (Cy 403
430044 AA464510 Hs 152812 ESTs 402
409956 AW103364 Hs 727 hibin, beta A (xdvin A, activin AB a 401
422420 U03398 Hs 1524 tumor nxrosis fxtor (ligand) superfami 400
420159 AI572490 Hs 99785 Homo sapiens cDNA FLJ21245 fis clone C 398
428227 AA321649 Hs 2248 small inducible cytokine subfamily B (Cy 391 422168 AA586894 Hs 112408 SlOOcalcium-binding protein A7 (psonas 387
452304 AA025386 Hs 61311 ESTs, Weakly similar to S10590 cysteine 384
412140 AA219691 Hs 73625 RAB6 interxdng, kinesm-like (rabkmes 382
414812 X72755 Hs 77367 monokiπe induced by gamma interferon 381
419833 AA251131 Hs 220697 ESTs 381
446232 AI281848 Hs 165547 ESTs 374
432398 AA307808 Hs 2979 trefoil fxtor 2 (spasmolytic protein 1) 3 70
451105 AI761324 gb wι60b11 x1 NCI CGAP Co16 Homo sapiens 367
413281 AA861271 Hs 34396 ESTs 3.66
432867 AW016936 Hs 233364 ESTs 366
424046 AF027866 Hs 138202 senne (or cyste e) proteinase inhibito 365
457465 AW301344 Hs 195969 ESTs 365
414918 AI219207 Hs 72222 Homo sapiens cDNA FU 13459 fis, clone PL 361
418738 AW388633 Hs 6682 ESTs 360
427778 AA412323 Hs 105323 ESTs 360
454293 H49739 Hs 134013 ESTs. Moderately similar to NK homeobox 359
452194 AI694413 Hs 298262 ESTs, Weakly simila to dJ88J8 1 [H sapi 357
442577 AA292998 Hs 163900 ESTs 357
426174 AA547959 Hs 115838 ESTs 353
452862 AW378065 Hs 8687 ESTs 351
418869 AW516565 Hs 258279 ESTs 348
430178 AW449612 Hs 152475 ESTs 348
430397 AI924533 Hs 105607 ESTs 346
418054 NM 002318 Hs 83354 lysyl oxidase-like 2 345
442295 AI827248 Hs 224398 Homo sapiens cDNA FU 11469 fis, ctone HE 344
425921 NM.007231 Hs 162211 solute earner family 6 (neurotraπsmttte 344
431764 AA515212 Hs 271819 Homo sapiens cDNA FU22751 fis, clone K 343
421948 L42583 Hs 111758 keratin 6A 343
444381 BE387335 Hs 283713 ESTs, Weakly similar to CA54 HUMAN COLLA 341
442896 R37725 Hs 261108 ESTs 3.41
452281 T93500 Hs 28792 Homo sapiens cDNA FLJ11041 (is. clone PL 339
444783 AK001468 Hs 62180 anillin (Drosophila Scraps homolog), xt 339
408832 AW085690 Hs 63428 ESTs 339
406685 M18728 gb Human nonspecific crossrexdng andg 337
437527 AI241019 Hs 145644 ESTs 337
433084 M18079 Hs 282265 fatty xid binding protein 2, intesdnal 337
452401 NM.007115 Hs 29352 tumor nxrosis fxtor, alpha-induced pro 336
441318 AI078234 Hs 176130 ESTs 335
458897 U85642 Hs 138506 ESTs 333
413808 J00287 Hs 182183 catdesmon 1 333
411274 NM 002776 Hs 69423 kallikrein 10 332
418406 X73501 Hs 84905 cytokeradn 20 332
419559 Y07828 Hs 91096 nng finger protein 332
423217 NM.000094 Hs 1640 collagen, type VII, alpha 1 (epidermolys 331
423271 W47225 Hs 126256 interieukin 1, beta 331
411558 AA102670 Hs 70725 gamma-aminobutync xid (GABA) A rxepto 330
427722 AK000123 Hs 180479 hypothedcal protein FLJ 20116 330
422310 AA316622 Hs 98370 cyt∞hrome P540 family member predicted 330
430704 AW813091 gb RC3-ST0186-240400-111-d07 ST0186 Homo 329
411263 BE297802 Hs 69360 kinesm-like 6 (mitodc centromere-assx 329
443211 AH 28388 Hs 143655 ESTs 329
443426 AF098158 Hs 9329 chromosome 20 open reading frame 1 3 28
441085 AW136551 Hs 181245 Homo sapiens cDNA FU12532 fis, clone NT 328
452121 NM 004081 Hs 70936 deleted in azoospermia 327
408633 AW963372 Hs 46677 PRO2000 protein 327
447342 AI199268 Hs 19322 ESTs 325
419229 AI827237 Hs 282884 ESTs 324
443957 AA521049 Hs 34487 hypothedcal protein FLJ23412 323
452699 AW295390 Hs 213062 ESTs 323
425188 AK002052 Hs 155071 hypothedcal protein FLJ11190 323
400289 X07820 Hs 2258 atnx metalloproteinase 10 (stromelysin 321
408524 D87942 Hs 46328 fucosyltransferase 2 (sxretor status in 320
437897 AA770561 Hs 146170 hypothetical protein FLJ22969 320
453922 AF053306 Hs 36708 budding uninhibited by benzimidazdes 1 319
453160 AI263307 Hs 146228 ESTs 319
406690 M29540 Hs 220529 carcinoembryonic andgen-related cell ad 319
430187 AI799909 Hs 158989 ESTs 318
416209 AA236776 Hs 79078 MAD2 (mitodc arrest deficient, yeast, h 316
447048 AW393080 Hs 228320 Homo sapiens cDNA FU23537 fis, ctone L 314
408113 T82427 Hs 194101 Homo sapiens cDNA FU20869 fis, clone A 314
425465 L18964 Hs 1904 protein kinase C, iota 3 13
425826 U97698 Hs 159593 mucin 6, gastπc 3 13
431662 AA513406 Hs 152307 ESTs 313
419216 AU076718 Hs 164021 small inducible cytokine subfamily B (Cy 313
418203 X54942 Hs 83758 CDC28 protein kinase 2 312
417315 AI080042 Hs 180450 nbosomal protem S24 311
433001 AF217513 Hs 279905 clone HQ0310 PRO0310p1 311
459587 AA031956 gb zk15e04 s1 Soaes_pregnant_utenjs NbH 311
450159 AI702416 Hs 200771 ESTs, Weakly similar to CAN2.HUMAN CALPA 311
434370 AF130988 Hs 58346 downless (mouse) homolog 310
421190 U95031 Hs 102482 mucin 5, subtype β, trxheobronchial 310
421379 Y15221 Hs 103982 small inducible cytokine subfamily B (Cy 310
420380 AA640891 Hs 102406 ESTs 310 414774 X02419 Hs 77274 plasm ogen xdvator, urokmase 310
415989 AI267700 Hs 111128 ESTs 309
407137 T97307 Hs 199067 v-erb-b2 avian erythroblasdc leukemia v 309
407289 AA135159 Hs 203349 Homo sapiens cDNA FLJ12149 fis, clone MA 309
420297 AI628272 Hs 88323 ESTs 308
447519 U46258 Hs 23448 ESTs 308
448045 AJ297436 Hs 20166 prostate stem cell antigen 307
431956 AK002032 Hs 272245 Homo sapiens cDNA FU11170 fis, clone PL 306
410286 AI739159 Hs 61898 DKFZP586N2124 protein 305
409632 W74001 Hs 55279 senne (or cysteine) proteinase inhibito 305
454034 NM 000691 Hs 575 aldehyde dehydrogenase 3 305
436481 AA379597 Hs 5199 HSPC150 protein similar to ubiquidn-con 305
430573 AA744550 Hs 136345 ESTs 305
428987 NM 004751 Hs 194710 glucosammyl (N-acetyl) transferase 3. m 304
424252 AK000520 Hs 143811 hypothedcal protein FU20513 304
436291 BE568452 Hs 5101 protein regulator of cytokinesis 1 303
415992 C05837 Hs 145807 Homo sapiens cDNA FU13593 fis, clone PL 303
411789 AF245505 Hs 72157 Homo sapiens adlican mRNA, complete eds 302
417956 AA210704 Hs 190465 ESTs 302
408908 BE296227 Hs 8915 seπne/threonme kinase 15 301
422330 D30783 Hs 115263 epiregulin 301
425071 NM 013989 Hs 154424 deiodmase, lodothyronine, type II 300
425761 AW664214 Hs 196729 ESTs 299
432978 AF126743 Hs 279884 DNAJ doman-contanmg 299
418546 AA224827 gb nc32g04 s1 NCI_CGAP_Pr2 Homo sapiens 299
425371 D49441 Hs 155981 mesothelin 299
422440 NM 004812 Hs 116724 aldo-keto reductase family 1. member B11 298
439453 BE264974 Hs 6566 thyroid hoππone rxeptor interxtor 13 298
413278 BE563085 Hs 833 interferon-sdmulated protein, 15 kDa 297
428450 NM_014791 Hs 184339 KIAA0175 gene product 295
424345 AK001380 Hs 145479 Homo sapiens cDNA FU10518 fis clone NT 295
433133 AB027249 Hs 104741 PDZ-bindmg kinase, T-cell oπgmated pr 294
432269 NM 002447 Hs 2942 mxrophage sdmuladng 1 rxeptor (c-met 294
432917 NM 014125 Hs 279812 PRO0327 protein 294
433384 AI021992 Hs 124244 ESTs 293
432731 R31178 Hs 287820 fibronxtin 1 293
420552 AK000492 Hs 98806 hypothetical protein 292
428303 AW974476 Hs 183601 regulator of G-protem signalling 16 292
409687 T51125 Hs 8493 ESTs 291
434377 AW137148 Hs 136348 osteoblast spxific fxtor 2 (fasciclin 289
417791 AW965339 Hs 111471 ESTs 289
457288 AA521458 Hs 192738 ESTs 289
456181 L36463 Hs 1030 ras inhibitor 289
450190 T51387 gb yb20e08 r1 Stratagene fetal spleen (9 288
411573 AB029000 Hs 70823 KIAA1077 protein 288
430204 AA618335 Hs 146137 ESTs, Weakly similar to putative [C eleg 288
434808 AF155108 Hs 256150 ESTs, Highly simila to NY-REN-41 aidge 287
450983 AA305384 Hs 25740 ER01 (S cerevιsιae)-lιke 287
418670 AA601036 Hs 285083 ESTs 287
416661 AA634543 Hs 79440 IGF-II mRNA-bmding protein 3 287
409723 AW885757 Hs 257862 ESTs 287
435099 AC004770 Hs 4756 flap structure-spxific endonuclease 1 286
408660 AA525775 Hs 292523 ESTs 286
434032 AW009951 Hs 206892 ESTs 285
418216 AA662240 Hs 283099 AF15q 14 protein 285
453331 AI240665 Hs 8895 ESTs 285
450221 AA328102 Hs 24641 cytoskeleton assxiated protein 2 284
402075 284
410145 AW886300 gb RC5-OT0078-100400-023-C11 OT0078 Homo 283
410681 AW246890 Hs 65425 calbindin 1 , (28kD) 283
439867 AA847510 Hs 161292 ESTs 283
443715 AI583187 Hs 9700 cyclm E1 283
420005 AW271106 Hs 133294 ESTs 283
417366 BE185289 Hs 1076 small prolme-πch protein 1B (comifiπ) 283
422283 AW411307 Hs 114311 CDC45 (cell division cycle 45 S cerevis 282
404567 2 82
422158 L10343 Hs 112341 protease inhibitor 3, skm-deπved (SKAL 282
449224 AW995911 Hs 299883 hypothetical protein FLJ23399 281
407584 W25945 Hs 18745 ESTs 281
453884 AA355925 Hs 36232 KIAA0186 gene product 281
449032 AA045573 Hs 22900 nuclear fxtor (erythroid-deπved 2)-lιk 280
422809 AK001379 Hs 121028 hypothetical protein FU10549 279
449722 BE280074 Hs 23960 cyclm B1 279
445676 AI247763 Hs 16928 ESTs 279
424308 AW975531 Hs 154443 minichromosome maintenance deficient (S 278
453028 AB0O6532 Hs 31442 RxQ protein-like 4 278
421777 BE562088 Hs 108196 HSPC037 protein 278
452571 W31518 Hs 34665 ESTs 2 77
420759 T11832 Hs 127797 ESTs 277
422675 BE018517 Hs 119140 eukaryodc translation initiation fxtor 277
412723 AA648459 Hs 179912 ESTs 276
439670 AF088076 Hs 59507 ESTs, Weakly similar to AC0048583 U1 sm 276
400298 AA032279 Hs 61635 six transmembrane epithelial antigen of 276 414569 AF109298 Hs 118258 prostate cancer assxiated protein 1 276
449378 AW664026 Hs 59892 ESTs 2 75
423903 M57765 Hs 1721 interieukin 11 275
412059 AA317962 Hs 249721 ESTs 275
431104 AW970859 Hs 269109 ESTs 275
439759 AL359055 Hs 67709 Homo sapiens mRNA full length insert cDN 275
450701 H39960 Hs 288467 Homo sapiens cDNA FU12280 fis, clone MA 275
452940 AA029722 Hs 20279 ESTs 274
408690 AW864542 gb PM4-SN0016120500-003-h02 SN0016 Homo 274
407777 AA161071 Hs 71465 squalene epoxidase 273
432201 AI538613 Hs 135657 ESTs 273
414416 AW409985 Hs 76084 lamm B2 273
414617 AI339520 Hs 20524 ESTs, Moderately simila to hexokinase I 273
432407 AA221036 Hs 285026 HERV-H LTR-assxiadng 1 273
444301 AK000136 Hs 10760 hypothedcal protein FU20129 272
450375 AA009647 Hs 8850 a dismtegnn and metalloproteinase doma 272
441362 BE614410 Hs 23044 RAD51 (S cerevisiae) homolog (E coli Re 272
408298 AI745325 Hs 271923 Homo sapiens cDNA FU22785 fis, clone K 272
426711 AA383471 Hs 180669 conserved gene amplified in osteosarcoma 271
429432 AI678059 Hs 202676 synaptonemal complex protein 2 271
450506 NM 004460 Hs 418 fibroblast xbvadon protein, alpha 271
427528 AU077143 Hs 179565 minichromosome mantenance deficient (S 271
418801 AA228366 Hs 115122 ESTs 271
440283 AI732892 Hs 190489 ESTs 271
429486 AF155827 Hs 203963 hypothedcal protein FU10339 271
408366 AW511255 Hs 258082 ESTs 270
406399 269
434217 AW01 795 Hs 23349 ESTs 268
449785 AI225235 Hs 288300 Homo sapiens cDNA FU 23231 fis, clone C 268
446269 AW263155 Hs 14559 hypothedcal protein FLJ10540 268
443349 AI052572 Hs 269864 ESTs 268
426514 BE616633 Hs 301122 bone morphogenedc protein 7 (osteogenic 267
417079 U65590 Hs 81134 interieukin 1 receptor antagonist 267
444754 T83911 Hs 11881 transmembrane 4 superfamily member 4 267
424687 J05070 Hs 151738 matnx metalloproteinase 9 (geladnase B 266
439979 AW600291 Hs 6823 hypothedcal protein FLJ10430 265
424408 AI754813 Hs 146428 collagen, type V, alpha 1 265
430832 AI073913 Hs 100686 ESTs, Weakly similar to sxreted cement 265
427217 AA399272 Hs 144341 ESTs 265
429170 NM.001394 Hs 2359 dual spxificity phosphatase 4 264
450400 AI694722 Hs 279744 ESTs 264
435380 AA679001 Hs 192221 ESTs 264
432375 BE536069 Hs 2962 S100 calcium-binding protein P 263
453700 AB009426 Hs 560 apolipoprotein B mRNA edidπg enzyme ca 263
422938 NM_001809 Hs 1594 centromere protein A (17kD) 263
453134 AA032211 Hs 118493 ESTs 263
420727 H75701 Hs 99886 complement component 4-bιndιng protein, 262
408868 AW292286 Hs 255058 ESTs 262
414972 BE263782 Hs 77695 KIAA0008 gene product 262
440255 AI932285 Hs 160569 ESTs 262
403055 262
443247 BE614387 Hs 47378 ESTs, Moderately similar to hypothetical 262
447400 AK000322 Hs 18457 hypothetical protein FLJ20315 261
413753 U17760 Hs 301103 Human DNA sequence from clone 272L16 on 261
445114 AW991959 Hs 254664 ESTs 261
422397 AJ223366 Hs 116051 myeloma overexpressed gene(ιπ a subset o 260
407366 AF026942 gb Homo sapiens cιg33 mRNA, partial sequ 260
432009 AL137424 gb Homo sapiens mRNA cDNA DKFZp761G2123 260
440249 AI246590 Hs 125325 ESTs 260
433220 AI076192 Hs 131933 ESTs 260
438533 AI440266 Hs 170673 ESTs, Weakly similar to AF126780 1 redn 260
436251 BE515065 Hs 5092 nucleolar protein (KKE D repeat) 260
424717 H03754 Hs 152213 wingless-type MMTV mtegradon site fami 260
448988 Y09763 Hs 22785 gamma-aminobutync xid (GABA) A recepto 260
425463 AK000740 Hs 157986 hypothetical protein FU20733 260
435370 AI964074 Hs 225838 ESTs 259
432215 AU076609 Hs 2934 πbonucleodde reductase M1 polypepdde 259
409142 AL136877 Hs 50758 chromosome-assxiated polypeptide C 259
443919 AI091284 Hs 135224 ESTs 258
413268 AL039079 Hs 75256 regulator of G-protem signalling 1 258
404519 258
414998 NM 002543 Hs 77729 oxidised low density lipoprotein (Ixdn 257
429597 NM 003816 Hs 2442 a dismtegnn and metalloproteinase doma 257
426841 AI052358 Hs 193726 ESTs 2 57
416768 AA363733 Hs 1032 regenerating islet-deπved 1 alpha (pane 257
417933 X02308 Hs 82962 thymidylate synthetase 256
433675 AW977653 Hs 110771 Homo sapiens cDNA FU21904 fis, clone H 256
441384 AA447849 Hs 288660 protease senne 23 256
451939 U80456 Hs 27311 single-minded (Drosophila) homolog 2 256
418867 031771 Hs 89404 msh (Drosophila) homeo box homolog 2 255
449042 AW294985 Hs 301148 potassium voltage-gated channel, Isk-rel 2 55
416065 BE267931 Hs 78996 proliferating ceH nuclear andgen 2 55
414132 AI801235 Hs 48480 ESTs 255 431890 X17033 Hs 271986 integnn. alpha 2 (CD49B, alpha 2 subum 255
407830 NM 001086 Hs 587 arylacetamide dexetylase (esterase) 255
434815 AF155582 Hs 46744 Corel UDP-galxtose N-xetylgalxtosamin 254
415250 F02614 Hs 27319 ESTs 254
435647 AI653240 Hs 49823 ESTs 254
459306 AW578452 Hs 232988 ESTs, Weakly similar to mucin [H sapiens 254
414361 AI086138 Hs 204044 ESTs 254
425782 U66468 Hs 159525 cell growth regulatory with EF-hand doma 253
416984 H38765 Hs 80706 diaphorase (NADH/NADPH) (cytochrome b-5 253
431183 NM 006855 Hs 250696 KDEL (Lys-Asp-Glu-Leu) endoplasmic retic 253
436043 AW963838 Hs 168830 Homo sapiens cDNA FU12136 fis, clone MA 253
456743 AI630124 Hs 7434 ESTs 253
410268 AA316181 Hs 61635 six transmembrane epithelial andgen of 252
424905 NM 002497 Hs 153704 NIMA (never in mitosis gene a)-related k 252
411734 AW374954 Hs 71779 Homo sapiens DNA from chromosome 19, cos 252
432657 AA831815 Hs 270940 ESTs 2 51
434080 AI820719 Hs 154662 hypothedcal protein PR01472 251
438190 AA780020 Hs 136798 ESTs 251
418969 W33191 Hs 28907 hypothedcal protein FU20258 251
446405 AW451259 Hs 57851 ESTs 251
450002 AI679524 Hs 201629 ESTs, Moderately similar to ALU8_HUMAN A 251
431808 M30703 Hs 270833 amphiregulm (schwannoma-deπved growth 251
429093 NM 000253 Hs 195799 microsomal tnglyceπde transfer protein 250
447634 AW967902 Hs 5152 Homo sapiens cDNA FU22618 fis, done H 250
436393 AW022213 Hs 143617 ESTs 250
453751 R36762 Hs 101282 Homo sapiens mRNA, cDNA DKFZp434B102 (fr 249
445669 AI570830 Hs 174870 ESTs 249
445865 AI262584 Hs 145575 ESTs 249
448437 AW470125 gb xw60c04 x1 NC l_CGAP_Pan1 Homo sapiens 249
414883 AA926960 Hs 77550 CDC28 protein kinase 1 249
406747 AI925153 Hs 217493 annexin A2 249
446921 AB012113 Hs 16530 small inducible cytokine subfamily A (Cy 249
426322 J05068 Hs 2012 transcobalamin I (vitamin B12 binding pr 248
412903 BE007967 Hs 155795 ESTs 248
422515 AW500470 Hs 117950 multifuncdonal polypeptide simila to S 248
447030 AW444659 Hs 232184 ESTs 248
448454 NM 005879 Hs 21254 TRAF mterxdng protein 248
419092 J05581 Hs 89603 mucin 1, transmembrane 248
406671 AA129547 Hs 285754 met proto-oncogene (hepatocyte growth fa 248
409640 U78722 Hs 55481 zinc finger protein 165 248
424639 AI917494 Hs 131329 ESTs 248
404171 247
414747 U30872 Hs 77204 centromere protein F (350/400kD, mitosin 247
407839 AA045144 Hs 161566 ESTs 247
410406 AI969703 Hs 301842 ESTs 247
452220 BE158006 Hs 212296 ESTs 246
427691 AW194426 Hs 20726 ESTs 246
421493 BE300341 Hs 104925 xtodermal-neural cortex (with BTB-like 246
444838 AV651680 Hs 208558 ESTs 246
413816 AW958181 Hs 189998 ESTs 246
408296 AL117452 Hs 44155 DKFZP586G1517 protein 246
436613 AA972691 Hs 192974 Homo sapiens cDNA FU12735 fis, clone NT 245
445417 AK001058 Hs 12680 Homo sapiens cDNA FU10196 fis clone HE 245
432874 W94322 Hs 279651 melanoma inhibitory xdvity 245
425268 AI807883 Hs 156932 ESTs 245
425397 J04088 Hs 156346 topoisomerase (DNA) II alpha (170kD) 245
408308 AL033377 Hs 44197 hypothedcal protein DKFZp564O0462 245
427961 AW293165 Hs 143134 ESTs 245
422363 T55979 Hs 115474 replicadon fxtor C (xdvator 1) 3 (38 245
433083 AL042759 Hs 191762 ESTs 2 45
439848 AW979249 gb EST391359 MAGE resequences, MAGP Homo 244
431924 AK000850 Hs 272203 Homo sapiens cDNA FU20843 fis, clone AD 244
431457 NM 012211 Hs 256297 integnn, alpha 11 244
443949 AW827419 Hs 235070 ESTs 244
416498 U33632 Hs 79351 potassium channel, subfamily K, member 1 244
428484 AF104032 Hs 184601 solute caπer family 7 (cationic ammo 243
431958 X63629 Hs 2877 cadheππ 3, type 1 , P-cadheπn (plxenta 243
413833 Z15005 Hs 75573 centromere protein E (312kD) 243
407243 AA058357 Hs 74466 carcinoembryonic andgen-related cell ad 243
410044 BE566742 Hs 58169 highly expressed in cancer, nch in leuc 243
424273 W4046O Hs 144442 phospholipase A2, group X 242
409533 AW969543 Hs 21291 mitogen-xdvated protein kinase kinase 242
453966 BE148734 Hs 252833 ESTs 242
427043 AA397679 Hs 298460 ESTs 242
419741 NM_007019 Hs 93002 ubiquitin earner protein E2-C 242
449987 AW079749 Hs 184719 ESTs, Weakly similar to AF116721 112 PRO 242
433159 AB035898 Hs 150587 kinesm-like protein 2 242
439396 BE562958 Hs 74346 ESTs. Weakly simila to /predicdon 242
426427 M86699 Hs 169840 TTK protein kinase 241
434725 AK000796 HS 4104 hypothetical protein 241
427719 AI393122 Hs 134726 ESTs 241
433312 AI241331 Hs 131765 ESTs 241
432615 AA557191 Hs 55028 ESTs 241 407047 X65965 gb H sapiens SOD-2 gene for manganese su 2 41
419220 AA811938 Hs291759 ESTs 240
416530 U62801 Hs 79361 kallikrein 6 (neurosin, zyme) 240
435219 AA676349 Hs 190331 ESTs 240
447164 AF026941 Hs 17518 Homo sapiens cιg5 mRNA partial sequence 240
416713 T70174 gb yc18b03 s1 Stratagene lung (937210) H 240
418322 AA284166 Hs 84113 cyclm-dependent kinase inhibitor 3 (CDK 240
409902 AI337658 Hs 156351 ESTs 240
443597 AI078418 gb oz05e03 x1 Soares fetal liver spleen_ 240
404253 240
428970 BE276891 Hs 194691 retinoic xid induced 3 240
443462 AI064690 Hs 171176 ESTs 239
418693 AI750878 Hs 87409 thrombospondin 1 239
451237 AW600293 gb EST00049 pGEM-T library Homo sapiens 239
407756 AA116021 Hs 38260 ubiquihn spxific protease 18 239
437935 AW939591 HS5940 hypothetical protein FU20063 239
445625 BE246743 Hs 288529 Homo sapiens cDNA FU22635 fis, clone H 2 39
435937 AA830893 Hs 119769 ESTs 239
438993 AA828995 gb od77b08 s1 NCI_CGAP_Ov2 Homo sapiens 238
422082 AA016188 Hs 111244 hypothetical protein 2 38
435849 BE305242 Hs 112442 ESTs. Weakly similar to CLDE.HUMAN CLAUD 238
407242 M18728 gb Human nonspecific crossreacdng andg 238
450396 AU077002 Hs 24950 regulator of G-protem signalling 5 238
430354 AA954810 Hs 239784 human homolog of Drosophila Scπbble 238
422578 AF239666 Hs1545 caudal type homx box transcnpdon fxt 238
446342 BE298665 Hs 14846 Homo sapiens mRNA cDNA OKFZp564D016 (fr 238
450737 AW007152 Hs 203330 ESTs 238
428070 T63918 Hs 182313 retinol-binding protein 2, cellular 238
416111 AA033813 Hs 79018 chromadn assembly fxtor 1 , subunit A ( 2 37
433345 AI681545 Hs 152982 Homo sapiens cDNA FU 13117 fis, clone NT 2 37
427557 NM 002659 Hs 179657 plasmmogen xdvator, urokinase rxepto 237
423554 M90516 Hs1674 glutamme-fructose-6-phosphate traπsamin 2 37
453204 R10799 Hs 191990 ESTs 2 37
453876 AW021748 Hs 110406 ESTs 236
425081 X74794 Hs 154443 minichromosome maintenance deficient (S 236
434682 AA827165 Hs 191958 ESTs 236
439737 AI751438 Hs41271 Homo sapiens mRNA full length insert cDN 236
414108 AI267592 Hs 75761 SFRS protein kinase 1 2 36
417900 BE250127 Hs 82906 CDC20 (cell division cycle 20, S cerevi 236
428046 AW812795 Hs 155381 ESTs, Moderately similar to I38022 hypot 2 36
448826 AI580252 Hs 293246 ESTs, Weakly similar to putative p150 (H 2 36
441020 W79283 Hs 35962 ESTs 236
448019 AW947164 Hs 195641 ESTs 236
431753 X76029 Hs 2841 neuromedin U 236
441703 AW390054 Hs 192843 ESTs 236
410361 BE391804 Hs62661 guanylate binding protein 1, interferon- 236
418526 BE019020 Hs 85838 solute earner family 16 (monxarboxyhc 236
444478 W07318 Hs240 M-phase phosphoprotein 1 2 36
421878 AA299652 Hs 111496 Homo sapiens cDNA FLJ11643 fis, clone HE 235
428388 AA729827 Hs 101265 Homo sapiens cDNA FU22593 fis, clone H 2 35
436961 AW375974 Hs 156704 ESTs 2 35
408194 AA601038 Hs 191797 ESTs 235
438578 AA811244 Hs 164168 ESTs 235
429183 AB014604 Hs 197955 KIAA0704 protein 235
435663 AI023707 Hs 134273 ESTs 235
430290 AI734110 Hs 136355 ESTs 234
423441 R68649 Hs 278359 absent in melanoma 1 like 234
453900 AW003582 Hs 226414 ESTs, Weakly similar to ALU8.HUMAN ALU S 233
450378 AW249181 Hs 19954 ESTs, Weakly simila to cDNA EST yk386e1 233
432877 AW974111 Hs 292477 ESTs 233
451928 AI823801 Hs 30315 ESTs 233
426227 U67058 Hs 168102 Human proteinase xdvated rxeptor 2 mR 233
418245 AA088767 Hs83883 transmembrane, prostate androgen induced 233
415083 AI632683 Hs 27179 Homo sapiens cDNA FLJ12933 fis, clone NT 2 33
435106 AA100847 Hs 193380 ESTs, Highly similar to AF174600 1 F-box 2 33
432193 AA372264 Hs 273193 hypothetical protein FU10706 233
458531 AA367718 Hs 159083 ESTs 2 33
449532 W74653 Hs 271593 ESTs 233
446354 AW449650 Hs 202249 ESTs 233
409703 NM 006187 Hs 56009 ?-5'olιgoadenylate synthetase 3 233
419373 NM 003244 Hs 90077 TG-interxdng fxtor (TALE family homeo 232
435607 W73428 Hs8750 uncharxtenzed bone marrow protein BM04 2 32
405818 232
423132 AF070647 Hs 124126 Homo sapiens clone 24438 mRNA sequence 2 32
444371 BE540274 Hs239 forkhead box M1 232
432675 AI791855 Hs 105884 ESTs 232
411773 NM 006799 Hs 72026 protease senne, 21 (testism) 2 31
448569 BE382657 Hs 21486 signal transducer and xdvator of trans 2 31
434775 AA648983 Hs 212911 ESTs 231
407378 AA299264 gb EST11752 Uterus Homo sapiens cDNA S 2 31
442353 BE379594 Hs 49136 ESTs 2 31
422611 AA158177 Hs 118722 fucosyltransferase 8 (alpha (1,6) fucosy 231
409965 AA079229 gb zm95f04 r1 Stratagene colon HT29 (937 2 31 421677 H64092 Hs 38282 ESTs 231
419493 AF001212 Hs 90744 proteasome (prosome, mxropain) 26S subu 231
424435 AB011167 Hs 146957 KIAA0595 protein 230
446880 AI811807 Hs 108646 Homo sapiens cDNA FU12534 fis, clone NT 230
452795 AW392555 Hs 18878 hypothetical protein FU21620 230
452834 AI638627 Hs 105685 ESTs 230
409262 AK000631 Hs 52256 hypothedcal protein FU20624 230
428125 AA393071 Hs 182579 leucine aminopeptidase 230
417655 AA780791 Hs 14014 ESTs, Weakly similar to KIAA0973 protein 229
407287 AI678812 Hs 201658 ESTs, Weakly similar to ALU4 HUMAN ALU S 229
428923 BE047698 Hs 188785 ESTs 229
452203 X57522 Hs 158164 ATP-b ding cassette, sub-family B (MDR/ 229
409402 AF208234 Hs 695 cystadn B (stefin 8) 229
419359 AL043202 Hs 90073 chromosome segregadon 1 (yeast homolog) 229
451999 AW176401 Hs 27424 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 2 29
400811 AF219139 Hs 87726 Kl AA0154 protein. ADP-πbosyladon fxto 229
436396 AI683487 Hs 299112 Homosapιens cDNA FU11441 fis, clone HE 228
442152 R39246 Hs 239666 Homo sapiens cDN A FU 13495 fis, done PL 228
420931 AF044197 Hs 100431 small inducible cytokine B subfamily (Cy 228
410174 AA306007 Hs 59461 DKFZP434C245 protein 228
425247 NM_005940 Hs 155324 matπx metalloproteinase 11 (stromelysin 2 28
438170 AI916685 Hs 194601 ESTs 228
445378 AV653564 Hs 226946 ESTs 228
428048 AA705745 Hs 185070 ESTs 228
414696 AF0O2O20 Hs 76918 Niemann-Pick disease, type C1 227
444665 BE613126 Hs 47783 ESTs, Weakly similar to T12540 hypothed 227
427660 AI741320 Hs 114121 Homo sapiens cDNA FU23228 fis, clone C 227
422128 AW881145 gb QV0-OT0033-010400-182-a07 OT0033 Homo 227
433535 AF111106 Hs 3382 protein phosphatase 4, regulatory subuni 227
415857 AA866115 Hs 301646 Homo sapiens cDNA FU11381 fis, clone HE 2 27
421155 H87879 Hs 102267 lysyl oxidase 227
405545 227
449467 AW205006 Hs 197042 ESTs 2 27
445537 AJ245671 Hs 12844 EGF-like-doman, muldple 6 227
450680 AF131784 Hs 25318 Homo sapiens clone 25194 mRNA sequence 2 26
423634 AW959908 Hs 1690 hepaπn-bmding growth fxtor binding pr 226
443868 W88483 Hs 293650 ESTs 2 26
407742 AF186252 Hs 38084 sulfotransferase family, cytosolic 1C, 226
428330 L22524 Hs 2256 matπx metalloproteinase 7 (matnlysm 2 26
432655 AA832195 Hs 292266 ESTs 226
429731 AK001592 Hs 212172 beta,beta-carotene 15,15'-dιoxygenase ho 2 26
400514 2 26
431846 BE019924 Hs 271580 uroplakm lB 2 26
439521 AI808955 Hs 58248 ESTs 2 26
426010 AA136563 Hs 1975 Homo sapiens cDNA FU21007 fis clone C 226
437641 AA811452 Hs 291911 ESTs 226
418982 AI348838 Hs 13073 ESTs 226
411393 AW797437 Hs 69771 B-fxtor, properdin 2 26
414809 AI434699 Hs 77356 transferπn rxeptor (p90 CD71) 225
419488 AA316241 Hs 90691 nucleophosmm/nucleoplasmin 3 2 25
434540 NM.016045 Hs 5184 TH1 drosophila homolog 225
449962 AA004879 Hs 187820 ESTs 225
410196 AI936442 Hs 59838 hypothedcal protein FU 10808 225
456844 AI264155 Hs 152981 CDP-dixylglycerol synthase (phosphadda 2 25
414368 W70171 Hs 75939 undine monophosphate kinase 225
408353 BE439838 Hs 44298 hypothedcal protein 2 25
439223 AW238299 Hs 23945 ESTs 225
448753 AL048858 Hs 224355 ESTs, Weakly similar to A39650 protein k 225
428479 Y00272 Hs 184572 cell division cycle 2, G1 to S and G2 to 224
432403 AA550815 Hs 124840 ESTs 2 24
424971 AA479005 Hs 154036 tumor suppressing subtransferable candid 224
432673 AB028859 Hs 278605 ER-assxiated DNAJ, ER assxiated Hsp40 224
446887 AI346656 Hs 156652 Homo sapiens cDNA FU22800 fis, clone K 2 24
452833 BE559681 Hs 30736 K1AA0124 protein 224
409432 D49372 Hs 54460 small inducible cytokine subfamily A (Cy 224
422039 BE567832 Hs 82148 hypothedcal protein 224
429925 NM.OO0786 Hs 226213 cytochrome P450, 51 (lanosterol 14-alpha 2 24
445413 AA151342 Hs 12677 CGI-147 protein 2 23
423645 AI215632 Hs 147487 ESTs 223
447532 AK000614 Hs 18791 hypothedcal protein FU20607 223
423515 AA327017 Hs 162204 ESTs 2 23
444743 AA045648 Hs 11817 nudix (nucleoside diphosphate linked moi 223
434518 H56995 Hs 37372 Homo sapiens DNA binding pepdde mRNA, p 2 23
435602 AF217515 Hs 283532 uncharxtenzed bone marrow protein BM03 223
449974 AW970948 Hs 269403 ESTs 2 23
424927 AW973666 Hs 153850 hypothedcal protein C321D24 223
457982 AW856093 Hs 183617 ESTs 223
414420 AA043424 Hs 76095 immediate early response 3 223
449019 AI949095 Hs 67776 ESTs Weakly simila to ALU7_HUMAN ALU S 223
431840 AA534908 Hs 2860 POU domain, class 5, transcnpdon fxto 2 23
452930 AW195285 Hs 194097 ESTs 223
436391 AJ227892 Hs 146274 ESTs 223
439186 AI697274 Hs 6487 Xq28, 2000bp sequence contg ORF 223 427254 AL121523 Hs 97774 ESTs 222
424517 AI539443 Hs 137447 Homo sapiens cDNA FU 12169 fis, clone MA 222
414732 AW410976 Hs 77152 minichromosome maintenance deficient (S 222
411835 U29343 Hs 72550 hyaluronan-mediated modlity receptor (R 2 22
427647 W19744 Hs 180059 Homo sapiens cDNA FLJ 20653 fis, clone KA 222
438223 AA781171 gb aj24d05 s1 Soares.testis.NHT Homo sap 2 22
434504 AI887341 Hs 121590 Homo sapiens cDNA FU12827 fis. clone NT 222
450149 AW969781 Hs 293440 ESTs, Moderately similar to ZIC2 protein 222
439211 AI890347 Hs 271923 Homo sapiens cDNA FU22785 fis, done K 222
401519 222
441794 AW197794 Hs 253338 ESTs 222
412108 AA100293 Hs 185043 ESTs 222
431849 AI670823 Hs 85573 Homo sapiens mRNA, cDNA DKFZp566N034 (fr 222
444969 AI203334 Hs 160628 ESTs 221
408901 AK001330 Hs 48855 hypothedcal protein FU 10468 2 21
434423 NM 006769 Hs 3844 LIM domain only 4 221
439328 W07411 Hs 118212 ESTs, Moderately similar to ALU3 HUMAN A 221
400021 AFFX control STAT1 221
432140 AK000404 Hs 272688 hypothedcal protein FU20397 221
434170 AA626509 Hs 122329 ESTs 221
423453 AW450737 Hs 128791 CGI-09 protein 221
428438 NM.001955 Hs 2271 endothelin 1 221
433102 AI343966 Hs 158528 ESTs 221
421470 R27496 Hs 1378 annexin A3 221
425499 T62489 gb yc03f09 r1 Stratagene lung (937210) H 221
438280 AW015534 Hs 217493 annexin A2 221
440381 AA917808 Hs 190495 ESTs 2 20
453779 N35187 Hs 43388 ESTs 220
433627 AF078866 Hs 284296 Homo sapiens cDNA FU22993 fis, clone K 220
417944 AU077196 Hs 82985 collagen, type V, alpha 2 220
452299 AW206330 Hs 73239 hypothedcal protein FU10901 220
422689 AW856665 gb RC3-CT0297-290100-013-J03 CT0297 Homo 220
448457 H65629 Hs 245997 ESTs 2 20
416221 BE513171 Hs 79086 mitochondnal nbosomal protein L3 220
426125 X87241 Hs 166994 FAT tumor suppressor (Drosophila) homolo 220
430603 AA148164 Hs 247280 HBV assxiated fxtor 220
425274 BE281191 Hs 155462 minichromosome maintenance deficient (mi 220
452679 Z42387 Hs 4299 Homo sapiens cDNA FU20965 fis, clone A 2 20
410619 BE512730 Hs 65114 keratin 18 220
424332 AA338919 Hs 101615 ESTs 2 20
442490 AW965078 Hs 30212 thyroid rxeptor interxdng protein 15 220
418661 NM_001949 Hs 1189 Human mRNA for KIAA0075 gene, partial cd 2 20
419341 N71463 Hs 118888 ESTs, Weakly similar to ALU1_HUMAN ALU S 2 20
427920 Z11502 Hs 181107 annexin A13 2 19
413879 AA132961 Hs 212533 Homo sapiens cONA FLJ22572 fis clone H 2 19
419752 AA249573 Hs 152618 ESTs 2 19
441436 AW137772 Hs 185980 ESTs 2 19
413095 AA494359 Hs 30715 ESTs 219
403208 2 19
422596 AF063611 Hs 118633 2 5Olιgoadenylate syπthetase-like 2 19
444261 AA298958 Hs 10724 MDS023 protein 2 19
419474 AW968619 Hs 155849 ESTs 2 19
453883 AI638516 Hs 77448 aldehyde dehydrogenase 4 (glutamate gamm 2 18
423401 NM 001992 Hs 128087 coagulation fxtor II (thrombin) rxepto 2 18
453450 AW797627 Hs 89474 ADP-πbosylation fxtor 6 2 18
440250 AA876179 Hs 134650 ESTs 2 18
444334 BE296785 Hs 10848 KIAA0187 gene product 2 18
437616 AI797163 Hs 207954 ESTs 2 18
451807 W52854 Hs 27099 OKFZP564J0863 protein 2 18
430441 BE398091 Hs 6880 DKFZP434D156 protein 2 18
414602 AW630088 Hs 76550 Homo sapiens mRNA, cDNA DKFZp564B1264 (f 2 18
411678 AI907114 Hs 71465 squalene epoxidase 2 18
453735 AI066629 Hs 125073 ESTs 2 18
450499 AA235207 Hs 250456 hypothetical protein DKFZp762F2011 2 18
452291 AF015592 Hs 28853 CDC7 (cell division cycle 7, S cerevisi 218
421532 AW138207 Hs 146170 hypothedcal protein FU22969 2 18
444342 NM.014398 Hs 10887 simila to lysosome-ass∞iated membrane 2 18
451099 R52795 Hs 25954 interieukin 13 rxeptor, alpha 2 2 18
444207 AI565004 Hs 79572 cathepsin D (lysosomal aspartyl protease 218
425873 NM.013390 Hs 160417 transmembrane protein 2 2 17
417404 NM.007350 Hs 82101 plxkstnn homology-like domain, family 2 17
449437 AI702038 Hs 100057 Homo sapiens cDNA FU22902 fis, clone K 2 17
446995 AI355012 gb qu16d10 x1 NCI.CGAP.Ov23 Homo sapiens 2 17
431548 AI834273 Hs9711 Homo sapiens cDNA FLJ 13018 fis, clone NT 217
411127 AA668995 Hs 218329 hypothedcal protein 2 17
439961 AA857451 Hs 269696 ESTs 2 17
429125 AA446854 Hs 271004 ESTs 2 17
407103 AA424881 Hs 256301 ESTs 2 17
435990 AI015862 Hs 131793 ESTs 2 17
415116 AA160363 Hs 269956 ESTs 2 17
440052 AI633744 Hs 195648 ESTs 2 17
423961 D13666 Hs 136348 osteoblast spxific fxtor 2 (fasciclm 2 17
431070 AW408164 Hs 249184 transcπption fador 19 (SC1) 2 16 443599 AI079559 Hs 134125 ESTs 2 16
423623 AB011117 Hs 129943 KIAA0545 protein 2 16
427258 AA400091 Hs 39421 ESTs 2 16
418113 AI272141 Hs 83484 SRY (sex determining region Y)-box 4 2 16
450835 BE262773 Hs 25584 hypothetical protein FLJ10767 2 16
428698 AA852773 Hs 297939 ESTs, Weakly similar to T17344 hypotheti 2 16
421408 AI688223 Hs 104114 H sapiens HCG 1 mRNA 2 16
449057 AB037784 Hs 22941 KIAA1363 protein 2 16
408947 AL080093 Hs 9117 Homo sapiens mRNA, cDNA DKFZp564N1662 (f 2 16
443552 N65982 Hs 109434 ESTs 2 16
448153 Y10805 Hs 20521 HMT1 (hnRNP methyltransferase, S cerevi 2 16
424653 AW977534 Hs 151469 calcium/calmodulm-dependent senne prot 2 16
431341 AA307211 Hs 251531 proteasome (prosome, mxropan) subunit 2 16
452865 AI924046 Hs 119567 ESTs 2 16
432789 D26361 Hs 3104 KIAA0042 gene product 2 16
438580 AA811262 Hs 299202 ESTs 2 16
422192 AA305159 Hs 113019 Λs485 2 15
425607 U09860 Hs 158333 protease, senne, 7 (eπterokmase) 2 15
447289 AW24701 Hs 36978 melanoma andgen, family A 3 2 15
447674 BE270640 Hs 19192 cyclin-dependent kinase 2 2 15
441021 AW578716 Hs 7644 H1 histone family, member 2 2 15
442432 BE093589 Hs 38178 Homo sapiens cDNA FU23468 fis, clone H 2 15
426471 M22440 Hs 170009 transforming growth fxtor, alpha 2 15
431941 AK000106 Hs 272227 Homo sapiens cDNA FU20099 fis, clone CO 2 15
414761 AU077228 Hs 77256 enhancer of zeste (Drosophila) homolog 2 2 15
447033 AI357412 Hs 157601 ESTs 2 15
410407 X66839 Hs 63287 carbonic anhydrase IX 2 15
446077 BE251048 Hs 22579 Homo sapiens clone CDABP0036 mRNA sequen 2 15
420900 AL045633 Hs 44269 ESTs 2 15
411975 AI916058 Hs 144583 ESTs, Weakly similar to gag (H sapiens] 2 15
419239 AA468183 Hs 184598 Homo sapiens cDNA FU23241 fis, clone C 2 15
449571 AW016812 Hs 200266 ESTs 2 15
452721 AJ269529 Hs 30377 Homo sapiens EST from clone 470080, full 215
410491 AA465131 Hs 64001 Homo sapiens clone 25218 mRNA sequence 2 14
410664 NM.006033 Hs 65370 lipase, endothelial 2 14
435730 AB020635 Hs 4984 KIAA0828 protein 2 14
452835 AK001269 Hs 30738 hypothedcal protein FU10407 2 14
452092 BE245374 Hs 27842 hypothedcal protein FU11210 2 14
401708 2 14
411400 AA311919 Hs 69851 GAR1 protein 2 14
448526 AB028946 Hs 21361 KIAA1023 protein 2 14
421175 AI879099 Hs 102397 GIOT-3 for gonadotropin inducible transc 2 14
412338 AA151527 Hs 69485 Homo sapiens cDNA FU 12436 fis, clone NT 2 14
420894 AA744597 Hs 88854 ESTs 2 14
409235 AA188827 Hs 7988 ESTs, Weakly similar to endo-alpha-D-man 2 14
412870 N22788 Hs 82407 Homo sapiens HSPC296 mRNA, partial eds 2 14
447760 AI431328 Hs 291179 ESTs, Weakly similar to topoisomerase I 2 14
413511 AI627178 Hs 75412 Arginme-πch protein 2 13
432945 AL043683 Hs 271357 ESTs, Weakly similar to unnamed protein 2 13
418592 X99226 Hs 284153 Fanconi anemia, comple entadon group A 2 13
441790 AW294909 Hs 132208 ESTs 2 13
425298 AK000209 Hs 155556 hypothedcal protein FU20202 2 13
450956 AW193531 Hs 205647 ESTs, Moderately similar to ALU1.HUMAN A 2 13
419569 AI971651 Hs 91143 jagged 1 (Alagille syndrome) 2 13
421508 NM.004833 Hs 105115 absent in melanoma 2 2 13
453975 AW009808 Hs 270829 ESTs 2 13
413670 AB000115 Hs 75470 hypothedcal protein, expressed in osteo 2 13
422783 AA598956 Hs 120439 ethanolamine kinase 2 13
444542 AI161293 Hs 146862 ESTs, Weakly simila to KIAA0525 protein 2 13
410418 D31382 Hs 63325 transmembrane protease, senne 4 2 13
419791 AI579909 Hs 105104 ESTs 2 13
414860 BE255593 Hs 77502 methionine adenosyltransferase II, alpha 2 13
425860 L29339 Hs 1964 solute earner family 5 (sodium/glucose 2 13
414839 X63692 Hs 77462 DNA (cytosme-5-)-methyltransferase 1 2 13
437050 AA766420 Hs 291606 ESTs 2 13
430217 N47863 Hs 180450 nbosomal protein S24 2 13
420923 AF097021 Hs 273321 differentially expressed in hematopoied 2 12
409012 AU 17435 Hs 49725 DKFZP434I216 protein 2 12
450645 AL117441 Hs 25264 DKFZP434N126 protem 2 12
431322 AW970622 gb EST382704 MAGE resequences, MAGK Homo 2 12
451356 AA748418 Hs 164577 ESTs 2 12
429534 AW976987 Hs 163327 ESTs 2 12
428365 AA295331 Hs 183861 Homo sapiens cDNA FU20042 fis, clone CO 2 12
441495 AW294603 Hs 127039 ESTs 2 12
443564 AI921685 Hs 199713 ESTs 2 12
410839 NM 006849 Hs 66581 protein disulfide isomerase 2 12
433640 AW390125 Hs 240443 Homo sapiens cDNA FU23538 fis, clone L 2 12
442947 R40800 Hs 21303 ESTs 2 12
414987 AA524394 Hs 165544 ESTs 2 12
450510 AA010056 Hs 242998 ESTs 2 12
427475 AA403151 Hs 191605 ESTs 2 12
444670 H58373 Hs 37494 ESTs 2 12
452099 BE612992 Hs 27931 hypothetical protein FU10607 similar to 2 12 433748 R12244 gb yf33c12 r1 Soares fetal liver spleen 2 12
415138 C18356 Hs 78045 dssue fxtor pathway inhibitor 2 2 11
438138 R98299 Hs 177502 ESTs 211
414788 X78342 Hs 77313 cyclm-dependent kinase (CDC2-lιke) 10 2 11
415474 NM 014252 Hs 78457 solute earner family 25 (mitxhoπdπal 2 11
416472 AA180756 Hs 193094 ESTs, Moderately similar to ALU4.HUMAN A 2 11
412490 AW803564 Hs 288850 Homo sapiens cDNA FU22528 fis, clone H 2 11
410718 AI920783 Hs 191435 ESTs 211
425811 AL039104 Hs 159557 karyophenn alpha 2 (RAG cohort 1 , impor 2 11
433344 AI741506 Hs 186753 ESTs, Weakly similar to ALU 1.HUMAN ALU S 2 11
447197 R36075 gb yh_8b01 s1 Soares plxenta Nb2HP Homo 211
431621 AW292329 Hs 163481 ESTs 211
418522 AA605038 Hs 7149 Homo sapiens cDNA FU21950 fis, ctone H 2 11
433849 BE465884 Hs 280728 ESTs 211
438038 AI732629 Hs 194161 ESTs, Weakly simila to TA2R HUMAN, BETA 211
422032 AA476966 Hs 110857 polymerase (RNA) III (DNA directed) poly 2 11
409717 AW452871 Hs 56043 CGI-115 protein 211
410566 AA373210 Hs 43047 Homo sapiens cDNA FU 13585 fis, clone PL 211
445837 AI261700 Hs 145544 ESTs 2 11
414334 AA824298 Hs 21331 hypothetical protein FU 10036 211
436326 BE085236 Hs 181244 major histocompadbility complex, class 210
423880 BE278111 Hs 134200 DKFZP564C186 protein 2 10
421574 AJ000152 Hs 105924 defensin, beta 2 210
437103 AW139408 Hs 152940 ESTs 210
435550 AI224456 Hs 4934 H sapiens polyA site DNA 210
450747 AI064821 Hs 48306 ESTs, Highly similar to EWS.HUMAN RNA-BI 210
437033 AW248364 Hs 5409 RNA polymerase I subunit 2 10
417640 030857 Hs 82353 protein C receptor, endothelial (EPCR) 210
431120 AA492588 gb πg99c08 s1 NCI_CGAP_Thy1 Homo sapiens 2 10
430510 AW162916 Hs 241576 hypothetical protein PR02577 2 10
429669 BE185499 Hs 2471 KIAA0020 gene product 210
407881 AW072003 Hs 40968 hepaan sulfate (glucosamine) 3-O-sulfot 2 10
436124 AA705012 Hs 269584 ESTs 2 10
436415 BE265254 Hs 5181 proliferadon-assxiated 2G4, 38kD 210
451121 AW973795 Hs 128927 Homo sapiens cDNA FU 13903 fis, clone TH 210
453968 AA847843 Hs 62711 ESTs 2 10
437549 AA759149 gb ah70e03 s1 Soares_tesds_NHT Homo sap 210
407887 AA579668 Hs 41072 senne (or cysteine) proteinase inhibito 210
447720 AL038765 Hs 161304 ESTs 209
434769 AA648884 Hs 134278 Homo sapiens cDNA FLJ12676 fis, clone NT 209
429743 AA804398 Hs 288995 hypothetical protein FU20813 209
447815 AI432199 Hs 247084 ESTs 209
441675 AI914329 Hs 5461 ESTs 209
434274 AA628539 Hs 116252 ESTs, Moderately similar to ALU1.HUMAN A 209
411571 AA122393 Hs 70811 hypothetical protein FU20516 209
442525 AF150282 Hs 145945 ESTs 209
423750 AF165883 Hs 132415 prefoldm 2 209
449199 AI990122 Hs 196988 ESTs 209
415363 AI670947 Hs 78406 phosphatιdylιnosιtol-4-p osptιate 5-kιnas 209
432543 AA552690 Hs 152423 Homo sapiens cDNA FU21274 fis, clone C 209
418462 BE001596 Hs 85266 integnn, beta 4 209
432093 H28383 gb yl52c03 r1 Soares breast 3NbHBst Homo 209
407862 BE548267 Hs 50724 Homo sapiens cDNA FLJ10934 fis, clone OV 209
434442 AA737415 Hs 152826 ESTs 209
442671 AI005668 Hs 134779 EST 209
428771 AB028992 Hs 193143 KIAA1069 protein 209
430335 D80007 Hs 239499 KIAA0185 protein 208
425087 R62424 Hs 126059 ESTs 208
412530 AA766268 Hs 266273 Homo sapiens cDNA FU13346 fis, clone OV 208
443450 N66045 Hs 133529 ESTs 208
418753 BE217818 Hs 87016 Homo sapiens cDNA FLJ22938 fis clone K 208
432204 AI916132 Hs 121593 Homo sapiens cDNA FU13123 fis, clone NT 208
439018 AW300887 Hs 26638 ESTs, Weakly similar to unnamed protein 208
418300 AI433074 Hs 86682 Homo sapiens cDNA FU21578 fis, clone C 208
431628 AF146277 Hs 265561 CD2-assxιated protein 208
446528 AU076640 Hs 15243 nucleola protein 1 (120kD) 208
432284 AA532807 Hs 105822 ESTs 208
411372 AI147861 Hs 213289 low density lipoprotein rxeptor (famili 208
459319 NM 000059 gb Homo sapiens breast cancer 2, early o 208
408730 AV660717 Hs 47144 DKFZP586N0819 protein 208
443607 AI452512 Hs 134069 ESTs 208
422058 AA862231 gb oe13g03 s1 NCI_CGAP_Ov2 Homo sapiens 208
409220 BE243323 Hs 51233 tumor nxrosis fxtor receptor superfami 208
429504 X99133 Hs 204238 lipxalm 2 (oncogene 24p3) 208
409686 AK000002 Hs 55879 Homo sapiens mRNA for FLJ00036 protein. 208
438394 BE379623 Hs 27693 CGI-124 protein 208
413092 AA126856 Hs 118665 ESTs 208
413715 AW851121 Hs 75497 Homo sapiens cDNA FLJ22139 (is, clone H 208
423020 AA383092 Hs 1608 replication protein A3 (14kD) 207
438378 AW970529 Hs 86434 Homo sapiens cDNA FU21816 fis, clone H 207
453379 AA035261 Hs 61753 ESTs 207
432125 AW972667 Hs 287510 Homo sapiens cDNA FU12300 fis, clone MA 207
449370 AK002114 Hs 23495 hypothedcal protein FU11252 207 449318 AW236021 Hs 108788 ESTs, Weakly similar to zeste [D melanog 207
450096 AI682088 Hs 223368 ESTs 207
454011 M31008 Hs 37009 alkaline phosphatase, intestinal 207
427876 AI494291 Hs 111977 ESTs 207
422901 R81936 Hs 121576 aspartate beta-hydroxylase 207
419235 AW470411 Hs 288433 neurotπmin 207
449207 AL044222 Hs 23255 nucleoponn 155kD 207
408243 Y00787 Hs 624 interieukin 8 207
415652 T79213 Hs 272073 ESTs 207
446546 BE167687 Hs 156628 ESTs 207
411765 H43346 gb yp09a04 r1 Soaes breast 3NbHBst Homo 207
423472 AF041260 Hs 129057 breast carcinoma amplified sequence 1 207
436211 AK001581 Hs 80961 polymerase (DNA dirxted), gamma 207
456157 AW979153 gb EST391263 MAGE resequences, MAGP Homo 206
407143 C14076 Hs 248968 EST 206
454269 AI961060 Hs 296411 ESTs, Moderately similar to KF1A.HUMAN K 206
432440 X63597 Hs 2996 sxrase-isomaltase 206
410668 BE379794 Hs 65403 hypothedcal protein 206
422765 AW409701 Hs 1578 bxuloviral IAP repeat-contaning 5 (sur 206
450434 AA166950 Hs 18645 ESTs, Weakly similar to partial CDS [C e 206
439832 T81829 Hs 14870 ESTs 206
456264 AW974175 Hs 105251 ESTs 206
431201 AA678405 Hs 8854 Human transcnpdon unit PVT gene, exons 206
445021 AK002025 Hs 12251 Homo sapiens cDNA FU11163 fis, clone PL 206
438714 AA814859 Hs 294112 ESTs 206
445318 AW500652 Hs 200885 ESTs 206
439951 AI347067 Hs 124636 ESTs 206
433681 AI004377 Hs 200360 Homo sapiens cDNA FU 13027 fis, clone NT 206
428307 W27393 Hs 183648 protein tyrosine phosphatase, rxeptor t 206
426874 N67325 Hs 247132 ESTs 206
451295 AI557212 Hs 17132 ESTs 206
432584 AA928829 Hs 47099 Homo sapiens cDNA FU21212 fis, done C 206
433027 AF191018 Hs 279923 putative nudeodde binding protein, est 206
433716 AA608808 Hs 225118 ESTs 206
429412 NM 006235 Hs 2407 POU domain, class 2, ass∞iadng fxtor 206
426235 AI631964 Hs 34447 ESTs 206
449026 BE500946 Hs 209105 ESTs 206
437016 AU076916 Hs 5398 guanine monphosphate synthetase 206
400019 AFFX control STAT1 206
408873 AL046017 Hs 23247 ESTs 206
442547 AA306997 Hs 268362 ESTs, Weakly similar to hypothedcal pro 206
455778 BE088746 gb CM2-BT0693-210300-123-d09 BT0693 Homo 206
439975 AW328081 Hs 6817 Homo sapiens putadve oncogene protein 206
433037 NM.014158 Hs 279938 HSPC067 protein 206
440086 NM 005402 Hs 288757 v-ral simian leukemia viral oncogene hom 206
436414 BE264633 Hs 143638 WD repeat domain 4 205
411770 NM 014278 Hs 71992 heat shxk protein (hspl 10 family) 205
407293 AA602234 Hs 270551 ESTs, Weakly similar to ALU1_HUMAN ALU S 205
409459 D86407 Hs 54481 low density lipoprotein rxeptor-related 205
436238 AK002163 Hs 301724 ESTs, Highly simila to unnamed protein 205
400517 AF242388 Hs 149585 lengs 205
439943 AW083789 Hs 124620 ESTs 205
421904 BE143533 Hs 109309 hypothetical protein FLJ 20035 205
417850 AA215724 Hs 82741 pπmase, polypepdde 1 (49kO) 205
417491 AW376842 Hs 1085 guanylate cyclase 2C (heat stable entero 205
453775 NM 002916 Hs 35120 replicadon fxtor C (xdvator 1) 4 (37 205
435525 AI831297 Hs 123310 ESTs 205
412627 BE391959 Hs 74276 chlonde mtrxellula channel 1 205
439702 AW085525 Hs 134182 ESTs 205
440006 AK000517 Hs 6844 hypothedcal protein FU20510 205
432979 AA573263 Hs 120860 ESTs 205
417308 H60720 Hs 81892 KIAA0101 gene product 205
432925 AA878324 Hs 192734 ESTs 205
446311 AW007294 Hs 149795 ESTs, Weakly similar to ALU1_HUMAN ALU S 205
427871 AW992405 Hs 59622 ESTs, Weakly simila to unknown (H sapie 205
453804 AA300204 Hs 35276 KIAA0852 protein 205
449939 T86420 Hs 272139 ESTs 205
455666 BE065813 gb RC2-BT0318-110100-012-a08 BT0318 Homo 205
417819 AI253112 Hs 133540 ESTs 204
427747 AW411425 Hs 180655 seπne/threomne kinase 12 204
415009 C75253 Hs 220950 ESTs 204
437829 AI358522 Hs 270188 ESTs 204
435381 AW136397 Hs 247572 ESTs 204
439778 AL109729 Hs 18948 ESTs Highly simila to HPS1_HUMAN PROTE 204
428753 AW939252 Hs 192927 hypothedcal protein FU20251 204
446475 A.908188 Hs 209245 ESTs 204
431394 AK0O0692 Hs 252351 HERV-H LTR-assxiadng 2 204
423701 AA329856 Hs 143022 ESTs 204
430680 AW138724 Hs 168974 ESTs, Highly simila to ALU7_HUMAN ALU S 204
422369 AF005216 Hs 115541 Janus kinase 2 (a protein tyrosine kinas 204
432481 AW451645 Hs 151504 Homo sapiens cDNA FU11973 fis, clone HE 204
443746 AW861379 Hs 160602 ESTs 204
400792 AA635062 Hs 50094 Homo sapiens mRNA, cDNA DKFZp434O0515 (f 204 432393 AW205863 Hs 133988 ESTs. Weakly similar to I52825 gene MAC2 204
430785 Z30201 gb HHEA22G Atnum cDNA library Human hea 204
428343 AL043021 Hs 12705 ESTs, Weakly similar to plakophidn 2b ( 204
419329 AY007220 Hs 288998 S100-type calcium binding protein A14 204
452488 N74921 Hs 184389 ESTs 204
403485 204
413313 NM.002047 Hs 75280 glycyl-tRNA synthetase 204
407634 AW016569 Hs 301280 ESTs, Highly similar to AF241831 1 infra 204
433326 AI379486 Hs 159430 ESTs 203
451129 BE072881 gb RC2-BT0548-200300-012-e09 BT0548 Homo 203
429165 AW009886 Hs 118258 prostate cancer assxiated protein 1 203
422963 M79141 Hs 13234 ESTs 203
418684 U82987 Hs 87246 Bcl-2 binding component 3 203
407824 AA147884 Hs 9812 ESTs 203
434551 BE387162 Hs 280858 ESTs, Highly similar to XPB HUMAN DNA-RE 203
440246 W52010 Hs 191379 ESTs 203
444006 BE395085 Hs 10086 type 1 transmembrane protein Fn14 203
431301 AA502384 Hs 151529 ESTs 203
452705 H49805 Hs 246005 ESTs 203
421724 AB037832 Hs 107287 KIAA1411 protein 203
420637 AW976153 gb EST388262 MAGE resequences MAGN Homo 203
450200 AW975625 Hs 173088 ESTs 203
447474 AW614220 Hs 189402 ESTs 203
418852 BE537037 Hs 273294 hypothedcal protein FU20069 203
445019 A1205540 Hs 281295 ESTs 203
435202 AI971313 Hs 170204 KIAA0551 protein 203
431842 NM 005764 Hs 271473 epithelial protein up-regulated in carci 203
436198 AK001125 Hs 300922 Homo sapiens cDNA FU10263 fis, clone HE 203
440773 AA352702 Hs 37747 hypothedcal protein FU 12484 203
443425 AI056776 Hs 133397 ESTs 203
454166 AW993356 Hs 2055 ubiquidn-xdvadng enzyme E1 (A1S9T an 203
407975 X89426 Hs 41716 endothelial cell-spxific molxule 1 (NO 203
428299 AL038004 Hs 29419 ESTs 203
418735 N48769 Hs 44609 ESTs 203
442053 R35343 Hs 24968 Human DNA sequence from clone RP1-233G16 203
415757 AA830854 Hs 187810 ESTs 203
432559 AW452948 Hs 257631 ESTs 203
425912 AL137629 Hs 162189 seπne/threonme kinase with Dbl- and pi 202
419395 BE268326 Hs 90280 5-amιnoιmιdazole-4-carboxamιde nboπucle 202
417576 AA339449 Hs 82285 phosphoπbosylglycinamide formyltransfer 202
418559 AA225048 Hs 104207 ESTs 202
410855 X97795 Hs 66718 RAD54 (S cerevisiae) like 202
433906 AI167816 Hs 43355 ESTs 202
422072 A8018255 Hs 111138 KIAA0712 gene product 202
419546 AA244199 gb nc06c05 s1 NCI_CGAP.Pr1 Homo sapiens 202
446229 AI744964 Hs 14449 KIAA1609 protein 202
450516 AA902656 Hs 21943 NIF3 (Ngg1 interxdng fxtor 3, S pombe 202
431721 AB032996 Hs 268044 KIAA1170 protein 202
419807 R77402 gb yι75f11 s1 Soares plxenta Nb2HP Homo 202
438192 AI859065 Hs 16808 ESTs, Weakly similar to paraplegm-like 202
401866 202
443129 R16075 Hs 21668 ESTs 202
426991 AK001536 Hs 285803 Homo sapiens cDNA FU 12852 fis clone NT 201
414731 AI890434 Hs 77135 Homo sapiens mRNA, cDNA DKFZp586A191 (fr 201
424783 AA913909 Hs 153088 TATA box binding protein (TBP) assxiate 201
413293 AL047483 Hs 75270 GTP-binding protein homologous to Saxha 201
435787 AW162767 Hs 100914 hypothetical protein FU 10352 201
422599 BE387202 Hs 118638 non-metastadc cells 1, protein (NM23A) 201
442660 AW138174 Hs 130651 ESTs 201
456553 AA721325 Hs 189058 ESTs, Weakly similar to cAMP-regulated g 201
431630 NM.002204 Hs 265829 integnn, alpha 3 (andgen CD49C, alpha 201
431300 AA502346 gb ne26b03 s1 NCI CGAP Co3 Homo sapiens 201
443180 R15875 Hs 70945 ESTs 201
450914 AI743761 Hs 142528 ESTs 201
448275 BE51 434 Hs 20830 synaptic Ras GTPase xdvadng protein 1 201
405484 201
436469 AK001455 Hs 5198 Down syndrome critical region gene 2 201
451273 NM 014811 Hs 26163 KIAA0649 gene product 201
439696 W95298 Hs 171882 ESTs 201
432378 AI493046 Hs 146133 ESTs 201
417975 AA641836 Hs 30085 Homo sapiens cDNA FU23186 fis, clone L 201
453665 AA6262S0 Hs 181165 eukaryodc translation elongadon fxtor 201
419981 AA897581 Hs 128773 ESTs 201
445808 AV655234 Hs 298083 ESTs 201
435767 H73505 Hs 117874 ESTs 201
430466 AF052573 Hs 241517 polymerase (DNA dirxted), theta 201
452747 BE153855 Hs 61460 ESTs 201
422790 AA809875 Hs 25933 ESTs 201
443303 U67319 Hs 9216 caspase 7 apoptosis-related cysteine pr 201
433929 AI375499 Hs 27379 ESTs 201
410008 AA079552 gb zm20h12 s1 Stratagene pancreas (93720 201
448954 AB014564 Hs 22616 KIAA0664 protein 200
440774 AI420611 Hs 127832 ESTs 200 451351 AW058261 Hs 168213 ESTs, Weakly similar to ALU1.HUMAN ALU S 200
442961 BE614474 Hs 289074 Homo sapiens cDNA FLJ 13986 (is, clone Y7 200
424420 BE614743 Hs 146688 prostaglandm E synthase 200
407154 H79677 gb yu76g10 s1 Soares fetal liver spleen 200
410240 AL157424 Hs 61289 synaptojanin 2 200
426830 AA385751 Hs 160392 ESTs 200
435014 BE560898 Hs 10026 πbosomal protein L17 isolog 200
408620 AI918693 Hs 81848 RAD21 (S pombe) homolog 200
432829 W60377 Hs 57772 ESTs 200
406752 AI285598 Hs 217493 annexin A2 200
TABLE 40A
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank axession numbers
Pkey CAT number Axession
408690 107490J AW864542 AA056567 AW882724
409965 116301J AA079229 AA079201 AA078874
410008 116812J AA079552 BE142525 BE142527
410145 1178960.1 AW886300 AW887902 AW887893 AW886291 AW592641
411765 125700.1 H43346 AA248302 AA095182
416713 1610889.1 T70174 H79244 T69850 H79151
418546 176677.1 AA224827 T59708 T59843 BE156903
419546 185766.1 AA244199 AA244272 H57440
419807 188252.1 R77402 AA262462 AA250988 R06794
420637 195241.1 AW976153 AA278945 AA747691
422058 210815.1 AA862231 AA659033 AA302799 AA302798
422128 211994.1 AW881145 AA490718 M85637 AA304575 T06067 AA331991
422689 219896.1 AW856665 AA315006 AW954733
425499 252539.1 T62489 T62634 AA828581 AA358569
430704 322217.1 AW813091 AW206655AA484440
430785 323486.1 Z30201 AA486132 T72025
431120 328264.1 AA492588 AA492498 AA492571
431300 331217.1 AA502346 BE159863
431322 331543.1 AW970622 AA503009 AA502998 AA502989 AA502805 T92188
432009 34025.1 AL137424 BE007148 T52277
432093 341283.1 H28383 AW972670 H28359 AA525808
433748 37385.1 R12244 H71290 AI110858 AF090916 AF075357 AA011531
434414 38585.1 AI798376 S46400 AW811617 AW811616 W00557 BE142245 AW858232 AW861851 AW858362 AA232351 AA218567 AA055556 AW858231
AW857541 AW814172 H66214 AW814398 AF134164 AA243093 AA173345 AA199942 AA223384 AA227092 AA227080 T12379 AA092174 T61139
AA149776 AA699829 AW879188 AW813567 AW813538 AI267168 AA157718 AA157719 AA10O472 AA100774 AA130756 AA157705 AA157730
AA157715 AA053524 AW849581 AW854566 C05254 AW882836 T92637 AW812621 AA206583 AA209204 BE156909 AA226824 AI829309 AW991957
N66951 AA527374 H66215 AA045564 AI694265 H60808 AA149726 AW195620 BE081333 BE073424 AW817662 AW817705 AW817703 AW817659
BE081531 H59570
437549 438403.1 AA759149 AW751066 AW844938 438223 452646.1 AA781171 AI202139 AI202098 438993 467651.1 AA828995 AA834879 AI926361 439848 477806.1 AW979249 D63277 AA846968 443597 574739.1 AI078418 W80626 AW387769 446995 702707.1 AI355012 AW812856 447197 711623.1 R36075 AI366546 R36167 448437 763310.1 AW470125 AI734872 AI749559 AW856504 AI583942 AW779036 AW843429 AW844876 AI520713 AW847236 450190 827655.1 T51387 AW191595 T51271 AI686285 451105 859083.1 AI761324 AW880941 AW880937 451129 859870.1 BE072881 BE072946 AI762181 451237 863269.1 AW600293AI767468 455666 1349545.1 BE065813 BE065788 BE065889 BE065832 455778 1364506.1 BE088746 BE088802 BE088755 BE088876 BE088947 BE088881 BE088952 456157 158261.1 AW979153 AA176967 AA826015
TABLE 40C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham, et al " refers to the publicadon entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted Nt.posidon Indicates nuclxdde posidons of predicted exons
Pkey Ref Strand Nt position
400514 9796594 Minus 78844-79025,80850-80991 ,89754-89941 ,93750-93891
401519 6649315 Plus 157315157950
401708 2951946 Plus 154511-155298
401866 8018106 Plus 73126-73623
402075 8117407 Plus 121907-122035,122804-122921,124019-124161,124455-124610,125672 126076
403055 8748904 Minus 109532-110225
403208 7630829 Minus 147706-147903,148667-148804
403422 9665041 Minus 151169-151561
403485 9966528 Plus 2888-3001 ,3198-3532,36554117
403776 7770611 Minus 1414-1513,1624-1756
404171 9930793 Plus 173667-173783,176876-177055
404253 9367202 Minus 55675-56055 404519 8152000 Plus 12817-13000
404567 7249169 Minus 101320-101501
405484 5922025 Plus 199214-199579,199672-199920,200262-200495
405545 1054740 Plus 118677-118807,119091-119296,121626-121823
405818 4071056 Plus 29055-29196
406399 9256288 Minus 63448-63554
TABLE 41A ABOUT 634 SEQUENCES UP-REGULATED IN STOMACH CANCER
Table 41 A lists about 634 genes up-regulated in stomxh cancer compared to normal adult dssues that are likely to be extrxellula or cell-surfxe proteins These were selxted as for Table 40A and the predicted protein contaned a structural doman that is indicadve of exfracellula tocalizadon (e g ig, ftι3, egf, 7tm domains) Predicted protein domains are noted
Pkey Unique Eos probeset idendfier number
ExA∞n Exempter Axession number, Genbank accession number
UnigenelD Unigene number
Unigene Tide Unigene gene dde
PSDoman Protein Structural Domain
R1 Rado of tumor to normal adult dssues
Pkey ExAccn UnigenelD Unigene Tide PSDoman R1
411243 AB039886 Hs 69319 CA11 SS 3066
418007 M13509 Hs 83169 matrix metallop hemopexin.Peptidase M10.SS 1694
448811 AI590371 Hs 174759 ESTs TM 11 08
409757 NM 001898 Hs 123114 cystadn SN cystadn.SS 1038
421110 AJ250717 HS 1355 cathepsin E asp.SS 911
428368 BE440042 Hs 83326 matnx metallop hemopexιn,Pepddase_M10,SS 866
406687 M31126 Hs 272620 pregnancy spxi hemopexin.TM, 7 11
428651 AF196478 Hs 188401 annexin A10 annexin.TM, 686
425211 M18667 Hs 1867 progastncsin ( asp.TM.SS 651
423673 BE003054 Hs 1695 matπx metallop hemopexιn,Peptιdase_M10,SS 649
409683 U33317 Hs 11 defensin alpha defensιns,Defensιn_propep,SS 639
428664 AK001666 Hs 189095 similar to SALL zf-C2H2,TM,SS 6 25
408380 AF123050 Hs 44532 diubiquidn ubιquιdn,7tm 3.ANF receptor,sushι,7tm_1,TM, 572
428953 AA306610 Hs 194676 DKFZP434C013 pr arf,TNFR_c6,DEAD,Stathmιπ,TM,SS 546
450685 L15533 Hs 423 pancreatids-as lxdn_c,TM,SS 540
409187 AF154830 Hs 50966 carbamoyl-phosp GATase.CPSase L chaιn,CPSase_sm_chaιn,MGS,TM, 534
434206 AW136973 Hs 288516 ESTs, Weakly si PH M, 5 16
421346 Z34277 Hs 103707 apomucin Cys.knot.vwd, 514
427585 D31152 Hs 179729 collagen, type C1q,Collagen,TM,SS 506
425679 X05997 Hs 159177 lipase, gastπc abhydrolase.SS 494
421582 AI910275 Hs 1406 trefoil fxtor trefoιl,trypsιn,TM,SS 493
422956 BE545072 Hs 122579 hypothedcal pr TM 489
448105 AW591433 Hs 170675 ESTs, Weakly si trypsin.TM, 484
413385 M34455 Hs 840 mdoleamine-pyr IDO M, 472
417866 AW067903 Hs 82772 collagen, type TSPN,Collagen,COLFI,SS 468
419278 AU076799 Hs 1247 apolipoprotein Apolipoprotem.SS 448
407811 AW190902 Hs 40098 cysteine knot s SS 447
403422 SS 438
403776 IL8.TM.SS 432
418478 U38945 Hs 1174 cyclin-dependen ank,TM,SS 432
428242 H55709 Hs 2250 leukemia inhibi LIF OSM.SS 430
421341 AJ243212 Hs 279611 deleted in mail SS 430
428434 AW363590 Hs 65551 ESTs Weakly si SS 413
409420 Z15008 Hs 54451 laminin, gamma lamιnιn_EGF,lamιnιn_B,SS 404
431611 U58766 Hs 264428 dssue spxific Epimerase.TM.SS 404
413719 BE439580 Hs 75498 small inducible IL8.SS 403
409956 AW103364 Hs 727 mhibin, beta A TGF-beta,TGFb propepdde.SS 401
422420 U03398 Hs 1524 tumor nxrosis TNF M, 400
428227 AA321649 Hs 2248 small inducible IL8,TM,SS 391
422168 AA586894 Hs 112408 S100calcιum-bι efhand.TM, 387
412140 AA219691 Hs 73625 RAB6 interxhn kmesin M.SS 382
414812 X72755 Hs 77367 monokme induce IL8.SS 381
419833 AA251131 Hs 220697 ESTs WHEP-TRS TM 381
446232 AI281848 Hs 165547 ESTs 7tm_3,TM, 374
432398 AA307808 Hs 2979 trefoil fxtor trefoιl,TM,SS 370
432867 AW016936 Hs 233364 ESTs GSHPx,TM,SS 366
424046 AF027866 Hs 138202 senne (or cyst serpin.TM, 365
414918 AI219207 Hs 72222 Homo sapiens cD TM 361
454293 H49739 Hs 134013 ESTs, Moderatel TM 359
442577 AA292998 Hs 163900 ESTs TM 357
426174 AA547959 Hs 115838 ESTs SS 3 53
418869 AW516565 Hs 258279 ESTs Sema.TM, 348
418054 NM 002318 Hs 83354 lysyl oxιdase-l Lysy Loxidase SRCR.SS 345
442295 AI827248 Hs 224398 Homo sapiens cD Collagen,COLFI,vwc,TM SS 344
425921 NM 007231 Hs 162211 solute earner SNF.TM, 344
421948 L42583 Hs 111758 keratin 6A filamentTM, 343
444783 AK001468 Hs 62180 amllin (Drosop PHJM, 339
437527 AI241019 Hs 145644 ESTs PIP5K.TM.SS 3 37
433084 M18079 Hs 282265 fatty xid bind hp∞alin SS 337
452401 NM 007115 Hs 29352 tumor nxrosis Xlιnk,CUB,TM,SS 3 36
458897 U85642 Hs 138506 ESTs TM 333
413808 J00287 Hs 182183 caldesmon 1 asp.TM.SS 333
411274 NM 002776 Hs 69423 kallikrein 10 trypsin.TM, 332 418406 X73501 Hs 84905 cytokeradn 20 filamentJM, 332
419559 Y07828 Hs 91096 πng finger pro zf-C3HC4,zf-B_box,TM, 332
423217 NM.000094 HS 1640 collagen, type fn3 Collagen Kunιtz_BPTI,vwa SS 331
411558 AA102670 Hs 70725 gamma-ammobuty neur chan.TM.SS 330
427722 AK000123 Hs 180479 hypothedcal pr PH.SS 330
422310 AA316622 Hs 98370 cytxhrome P540 p450,SS 330
411263 BE297802 Hs 69360 kinesm-like 6 kmesin.TM, 329
443426 AF098158 Hs 9329 chromosome 20 o TM 328
452121 NM 004081 Hs 70936 deleted in azoo TM 327
447342 AI199268 Hs 19322 ESTs TM.SS 325
452699 AW295390 Hs 213062 ESTs TM 323
425188 AK002052 Hs 155071 hypothedcal pr TM 323
400289 X0782O Hs 2258 matπx metallop hemopexm.SS 321
408524 D87942 Hs 46328 fucosyltransfer Qyco transf 11, TM.SS 320
437897 AA770561 Hs 146170 hypothedcal pr TM 320
453922 AF053306 Hs 36708 budding umnhib TM 3 19
406690 M29540 Hs 220529 carcinoembryoni I9.TM.SS 3 19
416209 AA236776 Hs 79078 MAD2 (mitodc a HORMASS 316
408113 T82427 Hs 194101 Homo sapiens cD 7tm_3,TM, 314
425465 L18964 Hs 1904 protein kinase Ski Sno.DAG PE-bmd,OPR,pkιse,pkιse_C,TM,SS 313
419216 AU076718 Hs 164021 small inducible IL8,TM,SS 3 13
418203 X54942 Hs 83758 CDC28 protein k CKSJM, 312
417315 AI080042 Hs 180450 nbosomal prote TM.SS 311
433001 AF217513 Hs 279905 done HQ0310 PR TM.SS 311
459587 AA031956 gb zk15e04 s1 S LIM.TM, 311
421379 Y15221 Hs 103982 small inducible IL8.TM.SS 3 10
414774 X02419 Hs 77274 plasminogen xt kπngle.trypsm.SS 3 10
407289 AA135159 Hs 203349 Homo sapiens cD TM 309
447519 U46258 Hs 23448 ESTs hιstone,Rιbosomal_L22e,TM, 308
448045 AJ297436 Hs 20166 prostate stem c TM.SS 307
431956 AK002032 Hs 272245 Homo sapiens cD RA.SS 306
409632 W74001 Hs 55279 senne (or cyst serpin.TM, 305
454034 NM 000691 Hs 575 aldehyde dehydr aldedh.TM, 305
436481 AA379597 Hs 5199 HSPC150 protein UQ_con,TM, 305
428987 NM 004751 Hs 194710 glucosammyl (N Branch.TM.SS 304
424252 AK000520 Hs 143811 hypothedcal pr casein kappa.SS 304
436291 BE568452 Hs 5101 protein regulat TM 303
411789 AF245505 Hs 72157 Homo sapiens ad ig.LRRCT.SS 302
417956 AA210704 Hs 190465 ESTs sushi.SS 302
408908 BE296227 Hs 48915 seπne/threonin pkιse,TM,SS 301
422330 D30783 Hs 115263 epiregulm EGF.TM.SS 301
425071 NM 013989 Hs 154424 deiod ase, lod T4 deiodise.TM SS 300
425761 AW664214 Hs 196729 ESTs SH3JM, 299
432978 AF126743 Hs 279884 DNAJ doman-con DJ.TM, 299
418546 AA224827 gb nc32g04 s1 N vwa.integπn A,FG-GAP,TM,SS 299
425371 D49441 Hs 155981 mesothelin TM.SS 299
422440 NM 004812 Hs 116724 aldo-keto reduc aldo ket_red,TM, 298
439453 BE264974 Hs 6566 thyroid hormone AAATM, 298
413278 BE563085 Hs 833 interferon-sdm ubiquidnJM, 297
428450 NM_014791 Hs 184339 KIAA0175 gene p pkιse,KA1,TM, 295
424345 AK001380 Hs 145479 Homo sapiens cD TM.SS 295
433133 AB027249 Hs 104741 PDZ-bmding k pkise TM, 294
432269 NM_002447 Hs 2942 mxrophage sdm pkιse,Sema,Plexιn_repeat,TIG,TM SS 294
432917 NM 014125 Hs 279812 PRO0327 protein TM 294
432731 R31178 Hs 287820 fibronxdn 1 SS 293
420552 AK000492 Hs 98806 hypothedcal pr SS 292
428303 AW974476 Hs 183601 regulator of G- RGS.TM, 292
409687 T51125 Hs 8493 ESTs Ets.SAM PNTJM, 291
457288 AA521458 Hs 192738 ESTs TM 289
456181 L36463 Hs 1030 ras inhibitor RA,VPS9,TM,SS 289
450190 T51387 gb yb20e08 r1 S SH3.TM, 288
430204 AA618335 Hs 146137 ESTs, Weakly si TM 288
434808 AF155108 Hs 256150 ESTs, Highly si TM 287
450983 AA305384 Hs 25740 ER01 (S cerevi SS 287
418670 AA601036 Hs 285083 ESTs TM 2 87
416661 AA634543 Hs 79440 IGF-II mRNA-bin KH-domaιn,TM, 287
435099 AC004770 Hs 4756 flap structure- XPG.I XPG.N.TM, 286
402075 serpm TM, 284
410681 AW246890 Hs 65425 calbmdin 1, (2 efhand,FHA,BRCT,adh_short.adh_short_C2,TM, 283
439867 AA847510 Hs 161292 ESTs TM 283
443715 AI583187 Hs 9700 cyclm E1 cycliπ.TM.SS 283
417366 BE185289 Hs 1076 small prolme-r Comifin.TM, 283
422283 AW411307 Hs 114311 CDC45 (cell dιv CDC45 TM.SS 282
404567 HECT,zf-UBR1,TM 282
422158 L10343 Hs 112341 protease inhibi wap.SS 282
449224 AW995911 Hs 299883 hypothedcal pr fn3,TM 281
407584 W25945 Hs 18745 ESTs PK.SS 281
453884 AA355925 Hs 36232 KIAA0186 gene ρ TM 2 81
449032 AA045573 Hs 22900 nuclea fxtor bZIP,Chromo_shadow,TM,SS 280
422809 AK001379 Hs 121028 hypothetical pr IQ TM, 2 79
449722 BE280074 Hs 23960 cyclm B1 cyclm.TM, 279
453028 AB0O6532 Hs 31442 RxQ proteiπ-li DEAD,helιcase_C,TM, 278
421777 BE562088 Hs 108196 HSPC037 protein TM 2 78 452571 W31518 Hs 34665 ESTs TM 277
422675 BE018517 Hs 119140 eukaiyodc tran elF-5a TM, 277
400298 AA032279 Hs 61635 six transmembra TM 276
414569 AF109298 Hs 118258 prostate cancer TM 276
449378 AW664026 Hs 59892 ESTs TM 275
423903 M57765 Hs 1721 interieukin 11 TM.SS 275
431104 AW970859 Hs 269109 ESTs Sema,TM,SS 275
452940 AA029722 Hs 20279 ESTs 7tm_1,TM,SS 274
432201 AI538613 Hs 135657 ESTs trypsin.TM, 273
414617 AI339520 Hs 20524 ESTs, Moderatel hexokise.TM, 273
444301 AKO0O136 Hs 10760 hypothetical pr LRR.TM, 272
426711 AA383471 Hs 180669 conserved gene TM 271
429432 AI678059 Hs 202676 synaptonemal co TM 271
450506 NM 004460 Hs 418 fibroblast xd Pepbdase S9,DPPIV_N_term,SS 271
427528 AU077143 Hs 179565 minichromosome MCM,TM,SS 271
418801 AA228366 Hs 115122 ESTs integnn A,FG-GAP,TM,SS 271
429486 AF155827 Hs 203963 hypothedcal pr SNF2 N.helicase C,TM, 271
408366 AW511255 Hs 258082 ESTs SS 270
406399 kazal,TM,SS 269
446269 AW263155 Hs 14559 hypothedcal pr TM 268
426514 BE616633 Hs 301122 bone morphogene TGF-beta,TGFb_propeptιde,TM,SS 267
417079 U65590 Hs 81134 interieukin 1 r IL1.SS 267
444754 T83911 Hs 11881 transmembrane 4 TM.SS 267
424687 J05070 Hs 151738 matπx metallop fn2,hemopexιn,Pepddase_M10.SS 266
439979 AW600291 Hs 6823 hypothedcal pr TM 265
430832 AI073913 Hs 100686 ESTs, Weakly si TM.SS 265
429170 NM 001394 Hs 2359 dual spxificit DSPc.Rhodanese.TM 264
450400 AI694722 Hs 279744 ESTs TM 264
435380 AA679001 Hs 192221 ESTs Oxludιn,TM,SS 264
432375 BE536069 Hs 2962 S100calcιum-bι S_100,efhand,TM,SS 263
453700 AB009426 Hs 560 apolipoprotein dCMP_cyt_deam,sugar_tr,TM SS 263
422938 NM 001809 Hs 1594 centromere prot histoneJM, 263
453134 AA032211 Hs 118493 ESTs adh_short,TM,SS 263
420727 H75701 Hs 99886 complement romp sushi, 262
408868 AW292286 Hs 255058 ESTs TM 262
414972 BE263782 Hs 77695 KIAA0008 gene p TM 262
403055 filamentJM.SS 262
447400 AK000322 Hs 18457 hypothedcal pr zf-C3HC4,TM, 261
413753 U17760 Hs 301103 Human DNA seque laminin EGF,lamιnιn_Nterm,SS 261
433220 AI076192 Hs 131933 ESTs TM 260
436251 BE515065 Hs 5092 nucleolar prote Nop.TM.SS 260
448988 Y09763 Hs 22785 gamma-ammobuty neur chan.TM.SS 260
425463 AK000740 Hs 157986 hypothetical pr TM 260
435370 AI964074 Hs 225838 ESTs EGF,fn3,fibππogen.C,TM,SS 2 59
432215 AU076609 Hs 2934 nbonucleotide πbonucleo.red.πboπuc.redjg TM, 259
409142 AL136877 Hs 50758 chromosome-asso SMC_N,TM,SS 259
443919 AI091284 Hs 135224 ESTs adh short,TM,SS 258
413268 AL039079 Hs 75256 regulator of G- RGS.TM, 258
404519 defensins, SS 258
414998 NM 002543 Hs 77729 oxidised low de TM 257
429597 NM 003816 Hs 2442 a dismtegnn a TM.SS 257
426841 AI052358 Hs 193726 ESTs asp.TM.SS 257
416768 AA363733 Hs 1032 regenerating is tecbn_c,SS 257
417933 X02308 Hs 82962 thymidylate syn thymidylat syntSS 256
441384 AA447849 Hs 288660 protease, seπn TM 256
451939 U80456 Hs 27311 single-minded ( PAC,PAS,BPL,BPL_C,TM, 2 56
418867 D31771 Hs 89404 msh (Drosophila homeoboxJM, 255
416065 BE267931 Hs 78996 proliferating c TM 255
431890 X17033 Hs 271986 integnn, alpha vwa,ιntegπn_A,FG-GAP,TM,SS 255
407830 NM 001086 Hs 587 arylacetamide d COesterase,7tm 1.TM.SS 255
434815 AF155582 Hs 46744 Corel UDP-galx SS 254
435647 AI653240 Hs 49823 ESTs TM 254
459306 AW578452 Hs 232988 ESTs, Weakly si TM.SS 254
414361 AI086138 Hs 204044 ESTs TM 254
425782 U66468 Hs 159525 cell growth reg SS 2 53
416984 H38765 Hs 80706 diaphorase (NAD TM 2 53
431183 NM 006855 Hs 250696 KDEL (Lys-Asp-G ER lumeπ_rxepLIRK,OEAD,helιcase_C,TM,SS 253
456743 AI630124 Hs 7434 ESTs TM 2 53
410268 AA316181 Hs 61635 six transmembra TM 252
424905 NM 002497 Hs 153704 NIMA (never in pkise.TM, 2 52
432657 AA831815 Hs 270940 ESTs TM 251
434080 AI820719 Hs 154662 hypothedcal pr DJ CXXCXGXGJM.SS 2 51
418969 W33191 Hs 28907 hypothedcal pr SH3.TM, 2 51
431808 M30703 Hs 270833 amphiregutin (s EGF.TM.SS 251
429093 NM 000253 Hs 195799 microsomal tπg Vιtellogenιn_N,TM SS 250
447634 AW967902 Hs 5152 Homo sapiens cD TM 250
436393 AW022213 Hs 143617 ESTs Galxtosy l_T_2,TM SS 250
453751 R36762 Hs 101282 Homo sapiens mR TM 249
445865 AI262584 Hs 145575 ESTs SS 249
414883 AA926960 Hs 77550 CDC28 protein k CKS.TM, 249
406747 AI925153 Hs 217493 annexin A2 TM 249
446921 AB012113 Hs 16530 small inducible IL8.SS 249
426322 J05068 Hs 2012 transcobalamm Cobalamιn_bιnd,TM,SS 248 422515 AW500470 Hs 117950 multifunctional AIRCSAICAR.syntTM, 248
447030 AW444659 Hs 232184 ESTs TM 248
448454 NM 005879 Hs 21254 TRAF interxdn zf-C3HC4,TM, 248
419092 J05581 Hs 89603 mucin 1, transm SEA TM.SS 248
409640 U78722 Hs 55481 zinc finger pro zf-C2H2,SCAN,TM, 248
404171 sodfe TM, 247
414747 U30872 Hs 77204 centromere prot SS 247
410406 AI969703 Hs 301842 ESTs FGGY.TM, 247
452220 BE158006 Hs 212296 ESTs FG-GAPJM.SS 246
421493 BE300341 Hs 104925 xtodermal-neur BTB.Kelch.TM, 246
444838 AV651680 Hs 208558 ESTs ιntegπn_A,FG-GAP,TM,SS 246
413816 AW958181 Hs 189998 ESTs AMP-bιndιng,G_glu_transpept,TM, 246
436613 AA972691 Hs 192974 Homo sapiens cD TM.SS 245
432874 W94322 Hs 279651 melanoma inhibi SH3.SS 245
425397 J04088 Hs 156346 topoisomerase ( HATPase_c,SS 245
422363 T55979 Hs 115474 replication fx TM 245
431924 AK000850 Hs 272203 Homo sapiens cD SH3.TM, 244
431457 NM 012211 Hs 256297 integnn, alpha FG-GAP,vwa,TM,SS 244
416498 U33632 Hs 79351 potassium chann TM 244
428484 AF104032 Hs 184601 solute earner aa_permeases TM, 243
431958 X63629 Hs 2877 cadheπn 3, typ cadheπn,Cadheπn_C_term,TM,SS 243
413833 Z15005 Hs 75573 centromere prot kmesin.TM, 243
407243 AA058357 Hs 74466 cacinoembryoni TM.SS 243
410044 BE566742 Hs 58169 highly expresse TM.SS 243
424273 W40460 Hs 144442 phospholipase A phoslip.TM.SS 242
409533 AW969543 Hs 21291 mitogen-xdvat TM.SS 242
419741 NM 007019 Hs 93002 ubiquitin cam UQ.coπ,efhand,TM,SS 242
449987 AW079749 Hs 184719 ESTs, Weakly si ABC_tran,ABC_membrane,TM, 242
433159 AB035898 Hs 150587 kinesm-like pr kιπesιn,Myosιn_taιl,TM,SS 242
439396 BE562958 Hs 74346 ESTs, Weakly si SS 242
426427 M86699 Hs 169840 TTK protein km pkise.TM, 241
434725 AK000796 Hs 4104 hypothetical pr TM 241
433312 AI241331 Hs 131765 ESTs zf-C2H2,SS 241
407047 X65965 gb H sapiens SO sodfe.TM 241
419220 AA811938 Hs 291759 ESTs TM.SS 240
416530 U62801 Hs 79361 kallikrein 6 (n trypsm,pro_ιsomerase,TM,SS 240
435219 AA676349 Hs 190331 ESTs TM 240
418322 AA284166 Hs 84113 cyclin-dependen SS 240
404253 histone TM SS 240
428970 BE276891 Hs 194691 retinoic xid i 7tm_3,TM 240
418693 AI750878 Hs 87409 thrombospondin EGF,TSPN,tsp_1,tsp_3,vwc SS 239
451237 AW600293 gb EST00049 pGE TM 239
407756 AA116021 Hs 38260 ubiquitin spxi UCH-1.UCH-2.SS 239
437935 AW939591 Hs 5940 hypothetical pr TM SS 239
445625 BE246743 Hs 288529 Homo sapiens cD TM 239
435937 AA830893 Hs 119769 ESTs TM 239
438993 AA828995 gb od77b08 s1 N ιntegπn_B,TM,SS 238
422082 AA016188 Hs 111244 hypothetical pr TM 238
450396 AU0770O2 Hs 24950 regulator of G- RGS M, 238
422578 AF239666 Hs 1545 caudal type hom homeobox.SS 238
428070 T63918 Hs 182313 rednol-binding lip∞alin.TM, 2 38
416111 AA033813 Hs 79018 chromadn assem TM.SS 237
433345 AI681545 Hs 152982 Homo sapiens cD TM 237
427557 NM 002659 Hs 179657 plasminogen xt UPAR LY6.SS 237
423554 M90516 Hs 1674 glutamme-fruct GATase_2,SIS,TM,SS 237
453204 R10799 Hs 191990 ESTs TM 237
425081 X74794 Hs 154443 minichromosome MCM TM, 236
434682 AA827165 Hs 191958 ESTs TM 236
414108 AI267592 Hs 75761 SFRS protein ki pkise.TM, 236
417900 BE250127 Hs 82906 CDC20 (cell dιv WD40.TM, 236
428046 AW812795 Hs 155381 ESTs, Moderatel ank,SS 236
448019 AW947164 Hs 195641 ESTs TM 236
431753 X76029 Hs 2841 neuromedm U NMU.TM.SS 236
410361 BE391804 Hs 62661 guanylate bindi GBP.TM.SS 236
418526 BE019020 Hs 85838 solute earner MCT.TM.SS 236
444478 W07318 Hs 240 M-phase phospho k esin.SS 236
436961 AW375974 Hs 156704 ESTs TM 235
408194 AA601038 Hs 191797 ESTs TM 235
438578 AA811244 Hs 164168 ESTs formyl_traιsf,AIRS,GARS,TM, 235
429183 AB014604 Hs 197955 KIAA0704 protei TM 235
453900 AW003582 Hs 226414 ESTs Weakly si TM 233
432877 AW974111 Hs 292477 ESTs Els.SAM.PNTJM, 233
451928 AI823801 Hs 30315 ESTs TM 233
418245 AA088767 Hs 83883 transmembrane, ldl_rxept_aTM,SS 233
435106 AA100847 Hs 193380 ESTs, Highly si TM 233
432193 AA372264 Hs 273193 hypothetical pr TM.SS 233
449532 W74653 Hs 271593 ESTs TM 233
409703 NM 006187 Hs 56009 2-5'olιgoadeny NTP_transf_2,TM,SS 233
419373 NM 003244 Hs 90077 TG-interxdng hom∞box.SS 232
435607 W73428 Hs 8750 uncharxteπzed SS 232
405818 TM.SS 232
444371 8E540274 Hs 239 forkhead box M1 Fori<_head,SS 232
432675 AI791855 Hs 105884 ESTs PDEaseJM, 232 411773 NM 006799 Hs 72026 protease seπn trypsm.SS 231
434775 AA648983 Hs 212911 ESTs TM.SS 231
422611 AA158177 Hs 118722 fucosyltransfer SS 2 31
419493 AF001212 Hs 90744 proteasome (pro SS 231
424435 AB011167 Hs 146957 KIAA0595 protei TM 230
409262 AK000631 Hs 52256 hypothedcal pr WD40,TM,SS 230
428125 AA393071 Hs 182579 leucine aminope Pepddase_M17,TM,SS 230
417655 AA780791 Hs 14014 ESTs, Weakly si TM 229
407287 AI678812 Hs 201658 ESTs, Weakly si ras,TM,SS 229
428923 BE047698 Hs 188785 ESTs TM.SS 229
452203 X57522 Hs 158164 ATP-biπding eas ABC_tran,ABC_membrane,TM, 229
409402 AF208234 Hs 695 cystadn B (ste cystadn.SS 229
419359 AL043202 Hs 90073 chromosome segr TM.SS 229
451999 AW176401 Hs 27424 DEAD/H (Asp-Glu TM.SS 229
400811 AF219139 Hs 87726 KIAA0154 protei Cobalamin bind.SS 229
420931 AF044197 Hs 100431 small inducible IL8,TM,SS 228
425247 NM 005940 Hs 155324 matπx metallop hemopexιn,Pepddase_M1 O M.SS 228
438170 AI916685 Hs 194601 ESTs 2-Hxιd DH.TM, 228
445378 AV653564 Hs 226946 ESTs TM 228
428048 AA705745 Hs 185070 ESTs AMP-bιndιng,TM 2 28
414696 AF0O2O20 Hs 76918 Niemann-Pick di Patched.TM.SS 227
433535 AF111106 Hs 3382 protein phospha TM 227
421155 H87879 Hs 102267 lysyl oxidase LysyLoxidase.SS 227
405545 ABC tran.ABC membrane.TM.SS 227
445537 AJ245671 Hs 12844 EGF-like-doman EGF.SS 227
423634 AW959908 Hs 1690 hepaπn-bmding TM.SS 226
407742 AF186252 Hs 38084 sulfotransferas Sulfotransfer.SS 226
428330 L22524 Hs 2256 matnx metallop Pepddase M10.SS 2 26
429731 AK001592 Hs 212172 beta.beta-carot TM 226
400514 p450,TM,SS 226
431846 BE019924 Hs 271580 uroplakin 1B transmembrane4,TM,SS 2 26
426010 AA136563 Hs 1975 Homo sapiens cD TM 226
437641 AA811452 Hs 291911 ESTs TM 226
411393 AW797437 Hs 69771 B-fxtor, prope sushι,trypsιn,vwa,DEAD rrm,EGF,fn3,fibππogen_C SS 226
414809 AI434699 Hs 77356 transfer™ rx PA,Rιbosomal S2.TM, 2 25
419488 AA316241 Hs 90691 nucleophosmin/n SS 225
434540 NM 016045 HS 5184 TH1 drosophila TM 225
410196 AI936442 Hs 59838 hypothedcal pr UBACT_repeat,TM, 2 25
456844 AI264155 Hs 152981 CDP-dixylglyce CyddylyϊtransJM, 225
408353 BE439838 Hs 44298 hypothedcal pr Ribosomal S17JM, 2 25
448753 AL048858 Hs 224355 ESTs, Weakly si TM 2 25
428479 Y00272 Hs 184572 cell division c pkise.TM SS 224
424971 AA479005 Hs 154036 tumor suppressi ion trans.PH.TM, 224
432673 AB028859 Hs 278605 ER-assxiated D DJ.DJ CJM.SS 2 24
409432 D49372 Hs 54460 small inducible IL8,TM,SS 224
429925 NM 000786 Hs 226213 cytxhrome P450 p450,TM,SS 2 24
445413 AA151342 Hs 12677 CGI-147 protein UPF0099,TM,SS 2 23
447532 AK000614 Hs 18791 hypothedcal pr TM 223
423515 AA327017 Hs 162204 ESTs SS 2 23
444743 AA045648 Hs 11817 nudix (nucleosi mutT.TM, 223
434518 H56995 Hs 37372 Homo sapiens DN TM 223
435602 AF217515 Hs 283532 uncharxtenzed TM.SS 223
449974 AW970948 Hs 269403 ESTs TM.SS 223
424927 AW973666 Hs 153850 hypothedcal pr TM 223
414420 AA043424 Hs 76095 immediate early TM 223
431840 AA534908 Hs 2860 POU domain da hom∞box,pou,TM,SS 2 23
452930 AW195285 Hs 194097 ESTs SS 223
436391 AJ227892 Hs 1 6274 ESTs SS 223
439186 AI697274 HS 6487 Xq28, 2000bp se Epimerase.SS 223
414732 AW410976 Hs 77152 minichromosome MCM.TM, 2 22
411835 U29343 Hs 72550 hyaluronaπ-medi TM 222
438223 AA781171 gb a|24d05 s1 S myosin head.TM, 2 22
450149 AW969781 Hs 293440 ESTs, Moderatel TM 222
401519 filamentJM, 2 22
441794 AW197794 Hs 253338 ESTs ank,TM, 222
408901 AK001330 Hs 48855 hypothetical pr TM 221
434423 NM.006769 Hs 3844 LIM domain only LIMJM, 221
432140 AK000404 Hs 272688 hypothetical pr SS 221
423453 AW450737 Hs 128791 CGI-09 protein Granιn,CDP-OH_P_transf,TM, 221
428438 NM 001955 Hs 2271 endothelin 1 endothelm.TM.SS 2 21
421470 R27496 Hs 1378 annexin A3 annexιn,TM,SS 221
440381 AA917808 Hs 190495 ESTs TM.SS 220
453779 N35187 Hs 43388 ESTs TM SS 220
433627 AF078866 Hs 284296 Homo sapiens cD SURF4.TM 220
417944 AU077196 Hs 82985 collagen, type COLFI.Collagen.vwc TM SS 220
422689 AW856665 gb RC3-CT0297-2 SNF2.NJM, 220
448457 H65629 Hs 245997 ESTs TM.SS 220
426125 X87241 Hs 166994 FAT tumor suppr EGF.cadheπn.lammin GJM.SS 2 20
430603 AA148164 Hs 247280 HBV assxiated zf-C3HC4,TM, 220
425274 BE281191 Hs 155462 minichromosome MCM.TM, 220
452679 Z42387 Hs 4299 Homo sapiens cD TM 220
410619 BE512730 HS 65114 keratin 18 filamentJM, 2 20
424332 AA338919 Hs 101615 ESTs SS 220 418661 NM 001949 Hs 1189 Human mRNA for E2F TDP.TM.SS 220
419341 N71463 Hs 118888 ESTs. Weakly si UPF0016.TM.SS 2 20
427920 Z11502 Hs 181107 annexin A13 annexmJM, 219
403208 lectιn_c,TM,SS 2 19
422596 AF063611 Hs 118633 ?-5'olιgoadeny ubiquidn.SS 2 19
444261 AA298958 Hs 10724 MDS023 protein TM 219
423401 NM.001992 Hs 128087 coagulation fx 7tm 1.TM.SS 2 18
453450 AW797627 Hs 89474 ADP-πbosylado SS 2 18
444334 BE296785 Hs 10848 KIAA0187 gene p SS 218
437616 AI797163 Hs 207954 ESTs SMC N.TM.SS 218
451807 W52854 Hs 27099 DKFZP564J0863 p TM 2 18
430441 BE398091 Hs 6880 DKFZP434D156 pr TM 218
411678 AI907114 Hs 71465 squalene epoxid Mon∞xygese.TM, 2 18
452291 AF015592 Hs 28853 COC7 (cell divi pkise.TM, 218
444342 NM 014398 Hs 10887 simila to lyso LampJM.SS 218
451099 R52795 Hs 25954 interieukin 13 fn3,TM,SS 218
425873 NM 013390 Hs 160417 transmembrane p TM 2 17
417404 NM 007350 Hs 82101 pteckstπn homo TM 217
446995 AI355012 gbqu16d10x1 TM 217
439961 AA857451 Hs 269696 ESTs TM 217
429125 AA446854 Hs 271004 ESTs TM 2 17
407103 AA424881 Hs 256301 ESTs TM 217
415116 AA160363 Hs 269956 ESTs ER lumen receptTM.SS 2 17
440052 AI633744 Hs 195648 ESTs PAC.TM.SS 217
423961 D13666 Hs 136348 osteoblast spx FasciclmJM.SS 217
431070 AW408164 Hs 249184 transcnpdon f FHASS 2 16
443599 AI079559 Hs 134125 ESTs TM 216
427258 AA400091 Hs 39421 ESTs TM 216
418113 AI272141 Hs 83484 SRY (sex detenu HMG.box TM, 216
450835 BE262773 Hs 25584 hypothedcal pr ArfGap SS 216
449057 AB037784 Hs 22941 KIAA1363 protei TM 2 16
448153 Y10805 Hs 20521 HMT1 (hnRNP met TM.SS 2 16
424653 AW977534 Hs 151469 calcium/calmodu Guanylate_kιn,PDZ,pkιse,SH3,TM, 2 16
431341 AA307211 Hs 251531 proteasome (pro proteasome.TM, 2 16
452865 AI924046 Hs 119567 ESTs PMP22 Claudιn,TM,SS 2 16
432789 D26361 Hs 3104 KIAA0042 gene p TM 2 16
438580 AA811262 Hs 299202 ESTs pkise.TM, 2 16
422192 AA305159 Hs 113019 fls485 SS 2 15
425607 U09860 Hs 158333 protease, senn ldl_recept_a,trypsιn,CUB,SRCR,MAM,SEA,TM,SS 2 15
447289 AW247017 Hs 36978 melanoma andge 3Beta_HSD,Epιmerase,MAGE,TM, 215
447674 BE270640 Hs 19192 cyclin-dependen pkise.TM, 2 15
441021 AW578716 Hs 7644 H1 histone fami linker histone.TM, 2 15
426471 M22440 Hs 170009 transforming gr EGFJM.SS 215
431941 AK000106 Hs 272227 Homo sapiens cD pkιse,Fuπn-lιke,TM,SS 2 15
414761 AU077228 Hs 77256 enhancer of zes SET.TM, 215
410407 X66839 Hs 63287 carbonic anhydr carb_aπhydrase,TM,SS 2 15
420900 AL045633 Hs 44269 ESTs Ald.Xan_dh_C,FAD_bιndιng_5,TM, 2 15
419239 AA468183 Hs 184598 Homo sapiens cD TM 2 15
452721 AJ269529 Hs 30377 Homo sapiens ES TM 2 15
410664 NM.006033 Hs 65370 Iφase, endothe Rιbosomal_L22,lιpase,PLAT,TM,SS 2 14
452835 AK001269 Hs 30738 hypothetical pr TM 2 14
452092 BE245374 Hs 27842 hypothetical pr AcyltransferaseJM.SS 2 14
401708 SS 2 14
411400 AA311919 Hs 69851 GAR1 protein TM 2 14
448526 AB028946 Hs 21361 KIAA1023 protei TM 2 14
421175 AI879099 Hs 102397 GIOT-3 for gona zf-C2H2,KRAB,TM,SS 2 14
413511 AI627178 Hs 75412 Arginine-πch p TM 2 13
432945 AL043683 Hs 271357 ESTs, Weakly si PK.SS 2 13
418592 X99226 Hs 284153 Fanconi anemia. TM 213
425298 AK00O2O9 Hs 155556 hypothetical pr TM 2 13
450956 AW193531 Hs 205647 ESTs, Moderatel pkise.TM.SS 2 13
419569 AI971651 Hs 91143 jagged 1 (Alagi EGF.DSLJM.SS 2 13
421508 NM.004833 Hs 105115 absent in melan TM 2 13
413670 AB000115 Hs 75470 hypothedcal pr TM 2 13
422783 AA598956 Hs 120439 ethanolamine ki Cholιne_kιse,TM, 2 13
410418 D31382 Hs 63325 transmembrane p tr psιn,ldl_rxept_a,TM,SS 2 13
414860 BE255593 Hs 77502 methionine aden S-AdoMet_syπt,SS 2 13
425860 L29339 Hs 1964 solute earner SSF,Rιbosomal_S17e,TM, 2 13
414839 X63692 Hs 77462 DNA (cytosιne-5 zf-CXXC,BAH,TM,SS 2 13
437050 AA766420 Hs 291606 ESTs TM 213
430217 N47863 Hs 180450 πbosomal prote TM.SS 213
409012 AL117435 Hs 49725 DKFZP434l216 pr RhoGEFJM, 2 12
428365 AA295331 Hs 183861 Homo sapiens cD TM 2 12
410839 NM.006849 Hs 66581 protein disulfi thioredJM, 2 12
450510 AA010056 Hs 242998 ESTs TM.SS 2 12
427475 AA403151 Hs 191605 ESTs SS 2 12
433748 R12244 gb yf33c12 r1 S AMP-bιndιng,TM, 2 12
415138 C18356 Hs 78045 tissue fxtor p Kunιtz_BPTI,G-gamma,TM,SS 2 11
414788 X78342 Hs 77313 cyclm-dependen pkise.TM.SS 2 11
415474 NM 014252 Hs 78457 solute earner mito carr.TM, 2 11
416472 AA180756 Hs 193094 ESTs, Moderatel TM 2 11
410718 AI920783 Hs 191435 ESTs SQS_PSY,TM,SS 2 11
425811 AL039104 Hs 159557 karyopheπn alp Armadιllo_seg,IBB,TM,SS 2 11 447197 R36075 gb yh88b01 s1 S SDFJM, 2 11
431621 AW292329 Hs 163481 ESTs PH.Band 41,TM,SS 2 11
433849 BE465884 Hs 280728 ESTs SS 2 11
438038 AI732629 Hs 194161 ESTs. Weakly si Cyddylyltrans TM, 2 11
422032 AA476966 Hs 110857 polymerase (RNA TFIIS TM SS 2 11
409717 AW452871 Hs 56043 CGI-115 protein TM 2 11
445837 AI261700 Hs 145544 ESTs TM 2 11
423880 BE278111 Hs 134200 DKFZP564C186 pr TM 210
421574 AJ000152 Hs 105924 defensin, beta Defensιn_beta,TM,SS 2 10
437103 AW139408 Hs 152940 ESTs Cholιne_kιse,TM, 210
450747 AI064821 Hs 48306 ESTs, Highly si rππJM, 2 10
437033 AW248364 Hs 5409 RNA polymerase TM 210
417640 D30857 Hs 82353 protein C recep TM.SS 210
431120 AA492588 gb ng99c08 s1 N TM.SS 2 10
430510 AW162916 Hs 241576 hypothedcal pr TM 210
429669 BE185499 Hs 2471 KIAA0020 gene p TM 210
407881 AW072003 Hs 40968 heparan sulfate SS 2 10
436415 BE265254 Hs 5181 proliferadon-a Pepddase_M24,TM,SS 210
407887 AA579668 Hs 41072 senne (or cyst serpiπJM, 2 10
447815 AI432199 Hs 247084 ESTs LIMJM, 209
434274 AA628539 Hs 116252 ESTs, Moderatel rrm.TM.SS 209
411571 AA122393 Hs 70811 hypothedcal pr SS 209
442525 AF150282 Hs 145945 ESTs pkise.TM, 209
423750 AF165883 Hs 132415 prefoldin 2 TM 209
449199 AI990122 Hs 196988 ESTs ras,TM, 209
415363 AI670947 Hs 78406 phosphaddydno PIP5K,pkιse,TM,SS 209
418462 BE001596 Hs 85266 integnn, beta integnn B,fn3,TM,SS 209
430335 D80007 Hs 239499 KIAA0185 protei S1.TM 208
443450 N66045 Hs 133529 ESTs TM 208
418753 BE217818 Hs 87016 Homo sapiens cD TM 208
439018 AW300887 Hs 26638 ESTs, Weakly si TM.SS 208
431628 AF146277 Hs 265561 CD2-assxιated SH3.SS 208
446528 AU076640 Hs 15243 nucleolar prote Nol1_Nop2_Sun,TM 208
411372 AI147861 Hs 213289 low density lip EGF,ldl_recept_a,ldl_rxept_b,TM,SS 208
459319 NM 000059 gb Homo sapiens BRCA2 repeatJM, 208
408730 AV660717 Hs 47144 DKFZP586N0819 p TM.SS 208
409220 BE243323 Hs 51233 tumor nxrosis TNFR_c6,death,TM, 208
429504 X99133 Hs 204238 lipxalin 2 (on lipocalin.SS 208
409686 AK000002 Hs 55879 Homo sapiens mR ABC tran,ABC membraπeJM, 208
413092 AA126856 Hs 118665 ESTs EGFJM.SS 208
413715 AW851121 Hs 75497 Homo sapiens cD cyclinJM, 208
423020 AA383092 Hs 1608 replicadon pro TM 207
438378 AW970529 Hs 86434 Homo sapiens cD TM.SS 207
432125 AW972667 Hs 287510 Homo sapiens cD Band 41JM.SS 207
449370 AK002114 Hs 23495 hypothetical pr TM.SS 207
454011 M31008 Hs 37009 alkaline phosph alk phosphatase.TM.SS 207
427876 AI494291 Hs 111977 ESTs TM 207
422901 R81936 Hs 121576 aspartate beta- SS 207
449207 AL044222 Hs 23255 nucleopoπn 155 TM.SS 207
408243 Y00787 Hs 624 interieukin 8 IL8.TM.SS 207
446546 BE167687 Hs 156628 ESTs Sulfotransfer,TM,SS 2 07
423472 AF041260 Hs 129057 breast cacinom TM 207
436211 AK001581 Hs 80961 polymerase (DNA TM 207
456157 AW979153 gb EST391263 MA transmembrane4,TM, 206
407143 C14076 Hs 248968 EST TM 206
432440 X63597 Hs 2996 sucrase-isomalt Glyco hydro 31,trefoιl,TM,SS 206
410668 BE379794 Hs 65403 hypothetical pr TM 206
422765 AW409701 Hs 1578 bxuloviral IAP BIR.TM, 206
439832 T81829 Hs 14870 ESTs SS 206
445318 AW500652 Hs 200885 ESTs TM 206
439951 AI347067 Hs 124636 ESTs T SS 206
428307 W27393 Hs 183648 protein tyrosin TM 206
432584 AA928829 Hs 47099 Homo sapiens cD SS 206
433027 AF191018 Hs 279923 putative nucleo MMR.HSR1JM, 206
433716 AA608808 Hs 225118 ESTs TM 206
429412 NM.006235 Hs 2407 POU domain, da TM 206
449026 BE500946 Hs 209105 ESTs TM 206
437016 AU076916 Hs 5398 guanine monphos GATase.GMP synt_C,TM, 206
442547 AA306997 Hs 268362 ESTs, Weakly si SS 206
455778 BE088746 gb CM2-BT0693-2 TM 206
439975 AW328081 Hs 6817 Homo sapiens pu TM.SS 206
433037 NM 014158 Hs 279938 HSPC067 protein TM 206
440086 NM 005402 Hs 288757 v-ral simian le ras TM 206
436414 BE264633 Hs 143638 WD repeat domai WD40.TM 205
411770 NM.014278 Hs 71992 heat shxk prot HSP70.TM, 205
409459 D86407 Hs 54481 low density lip EGF.Idl.recept a Idl.recept.bJM SS 205
436238 AK002163 Hs 301724 ESTs, Highly si MMR HSR1 TM, 205
400517 AF242388 Hs 149585 lengsin TM 205
421904 BE143533 Hs 109309 hypothedcal pr SS 205
417850 AA215724 Hs 82741 pnmase, polype SS 205
417491 AW376842 Hs 1085 guanylate cycla pkise guanylate cycANF rxeptor TM.SS 205
453775 NM.002916 Hs 35120 replication fx AAA.TM.SS 205
435525 AI831297 Hs 123310 ESTs TM 205 412627 BE391959 Hs 74276 chlonde intrx G-patch,ιg,MutS_C,TM, 205
439702 AW085525 Hs 134182 ESTs A2M SS 205
440006 AK000517 Hs 6844 hypothedcal pr TM 205
417308 H60720 Hs 81892 KIAA0101 geπe p TM 205
446311 AW007294 Hs 1 9795 ESTs, Weakly si pkise TM, 205
427871 AW992405 Hs 59622 ESTs, Weakly si SS 205
453804 AA300204 Hs 35276 KIAA0852 protei TM.SS 205
449939 T86420 Hs 272139 ESTs DIL,myosιn_head,TM,SS 205
417819 AI253112 Hs 133540 ESTs TM 204
427747 AW411425 Hs 180555 seπne/threonm pkise.TM, 204
415009 C75253 Hs 220950 ESTs TM 204
437829 AI358522 Hs 270188 ESTs TM 204
428753 AW939252 Hs 192927 hypothedcal pr TM 204
446475 AI908188 Hs 209245 ESTs OPRJM 204
431394 AK000692 Hs 252351 HERV-H LTR-asso ig TM.SS 204
423701 AA329856 Hs 143022 ESTs TM 204
422369 AF005216 Hs 115541 Janus kinase 2 SH2,pkιse,TM, 204
432481 AW451645 Hs 151504 Homo sapiens cD TSPN,Collagen,TM,SS 204
443746 AW861379 Hs 160602 ESTs TM 204
400792 AA635062 Hs 50094 Homo sapiens mR zf C3HC4 CARD.BIRJM, 204
428343 AL043021 Hs 12705 ESTs, Weakly si TM 204
419329 AY007220 Hs 288998 S100-type calcι TM 204
403485 filamentTM, 204
413313 NM 002047 Hs 75280 glycyl-tRNAsyn WHEP-TRS,7tm 2JM.SS 204
433326 AI379486 Hs 159430 ESTs TM 203
440246 W52010 Hs 191379 ESTs serpin.TM, 203
444006 BE395085 Hs 10086 type I transmem TM.SS 203
452705 H49805 Hs 246005 ESTs TM 203
421724 AB037832 Hs 107287 KIAA1411 protei TM 203
447474 AW614220 Hs 189402 ESTs SS 203
418852 BE537037 Hs 273294 hypothetical pr TM 203
431842 NM_005764 Hs 271473 epithelial prot TM.SS 203
440773 AA352702 Hs 37747 hypothedcal pr TM 203
443425 AI056776 Hs 133397 ESTs TM.SS 203
407975 X89426 Hs 41716 endothelial cel IGFBP.SS 203
428299 AL038004 Hs 29419 ESTs TM SS 203
415757 AA830854 Hs 187810 ESTs TM 203
432559 AW452948 Hs 257631 ESTs PACJM SS 203
425912 AL137629 Hs 162189 senne/threonin frι3,ιg PH,RhoGEF,TM,SS 202
419395 BE268326 Hs 90280 5-amιnoιmιdazol AICARFT_IMPCHas,MGS,TM, 202
417576 AA339449 Hs 82285 phosphoπbosylg AIRS,formyl_transf,GARS TM, 202
418559 AA225048 Hs 104207 ESTs TM 202
410855 X97795 Hs 66718 RAD54 (S cerevi SNF2_N helicase.CJM, 202
422072 A8018255 Hs 111138 KIAA0712gene p TM 202
419546 AA244199 gb nc06c05 s1 N Y_phosphatase,TM. 202
450516 AA902656 Hs 21943 NIF3 (Ngg1 inte DUF34 TM, 202
419807 R77402 gb yι75f11 s1 S TM 202
438192 AI859065 Hs 16808 ESTs, Weakly si TM.SS 202
401866 filament,TM,SS 202
443129 R16075 Hs 21668 ESTs TM.SS 202
424783 AA913909 Hs 153088 TATA box bmdin TM 201
413293 AL047483 Hs 75270 GTP-binding pro ras.TM SS 201
435787 AW162767 Hs 100914 hypothetical pr SS 201
422599 BE387202 Hs 118638 non-metastatic NDK.SS 201
431630 NM 002204 Hs 265829 integnn, alpha FG-GAP,ιntegnn_A,TM,SS 201
448275 BE514434 Hs 20830 synaptic Ras GT kιnesιn,PHD,abhydrolase_2,TM,SS 201
405484 filament,SS 201
436469 AK001455 Hs 5198 Down syndrome c TM 201
451273 NM 014811 Hs 26163 KIAA0649 gene p TM 201
432378 AI493046 Hs 146133 ESTs TM 201
419981 AA897581 Hs 128773 ESTs Ski.Sno.SS 201
445808 AV655234 Hs 298083 ESTs sushι,TM,SS 201
435767 H73505 Hs 117874 ESTs Pepddase S8.PJM, 201
430466 AF052573 Hs 241517 polymerase (DNA TM 201
422790 AA809875 Hs 25933 ESTs TM 201
443303 U67319 Hs 9216 caspase 7, apop ICE plO.lCE 201
410008 AA079552 gb zm20h12 s1 S FG-GAP TM.SS 201
440774 AI420611 Hs 127832 ESTs zf-MYND,TM,SS 200
442961 BE614474 Hs 289074 Homo sapiens cD TM 200
424420 BE614743 Hs 146688 prostaglandin E MAPEGJM.SS 200
410240 AL157424 Hs 61289 synaptojanm 2 TM 200
435014 BE560898 Hs 10026 nbosomal prote Ribosomal L17JM. 200
406752 AI285598 Hs 217493 annexin A2 TM 200
TABLE 41B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank accession numbers
Pkey CAT number Axession
410008 116812.1 AA079552 BE142525 BE142527
418546 176677 1 AA224827 T59708 T59843 BE156903
419546 185766.1 AA244199 AA244272 H57440 419807 188252 1 R77402 AA262462 AA250988 R06794
422689 219896 1 AW856665 AA315006 AW954733
431120 328264 1 AA492588 AA492498 AA492571
433748 37385 ϊ Rl 2244 H 1290 Al 110858 AF090916 AF075357 AA011531
438223 452646 1 AA781171 AI202139 AI202098
438993 467651 1 AA828995 AA834879 AI926361
446995 702707 1 AI355012 AW812856
447197 711623 1 R36075AI366546 R36167
450190 827655 1 T51387 AW191595 T51271 AI686285
451237 863269 1 AW600293AI767468
455778 1364506 1 BE088746 BE088802 BE088755 BE088876 BE088947 BE088881 BE088952
456157 158261 1 AW979153 AA1 6967 AA826015
TABLE 41 C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this ∞lumn are Genbank Idendfier (Gl) numbers "Dunham, et al * refers to the publicadon endded The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495 Strand Indicates DNA strand from which exons were predicted
NLposidon Indicates nudeodde posidons of predicted exons
Pkey Ref Strand NLposition
400514 9796594 Minus 78844-79025,80850-80991,89754-89941,93750-93891
401519 6649315 Plus 157315-157950
401708 2951946 Plus 154511-155298
401866 8018106 Plus 73126-73623
402075 8117407 Plus 121907-122035.122804-122921,124019-124161,124455124610,125672-126076
403055 8748904 Minus 109532-110225
403208 7630829 Minus 147706-147903,148667-148804
403422 9665041 Minus 151169-151561
403485 9966528 Plus 2888-3001 ,3198-3532,3655-4117
403776 7770611 Minus 1414-1513,1624-1756
404171 9930793 Plus 173667-173783,176876-177055
404253 9367202 Minus 55675-56055
404519 8152000 Plus 12817-13000
404567 7249169 Minus 101320-101501
405484 5922025 Plus 199214-199579,199672-199920,200262-200495
405545 1054740 Plus 118677-118807,119091-119296,121626-121823
405818 4071056 Plus 29055-29196
406399 9256288 Minus 63448-63554
TABLE 42A ABOUT 561 GENES UP-REGULATED IN STOMACH CANCER
Table 42A lists about 561 genes up-regulated in stomxh cancer compared to normal stomxh These were selxted as for Table 40A except using vaπous non-malignant stomxh spximens in detemiining the denominator value
Pkey Unique Eos probeset idendfier number
ExAxn Exemplar Axession number, Genbank xcession number
UnigenelD Unigene number
Unigene Tide Unigene gene dtle
R1 Rado of tumor to normal dssue
Pkey ExAxn UnigenelD Unigene Title R1
428368 BE440042 Hs 83326 matnx metalloproteinase 3 (stromelysiπ 604
448693 AW004854 Hs 228320 Homo sapiens cDNA FU23537 fis, clone L 286
428664 AK001666 Hs 189095 similar to SALL1 (sal (Drosophιla)-lιke 268
422330 D30783 Hs 115263 epiregulm 220
415989 AI267700 Hs 111128 ESTs 21 2
439979 AW600291 Hs 6823 hypothedcal protein FU 10430 190
451099 R52795 Hs 25954 interieukin 13 rxeptor, alpha 2 17 1
403776 149
424905 NM.002497 Hs 153704 NIMA (never in mitosis gene a)-related k 148
414132 AI801235 Hs 48480 ESTs 142
450375 AA009647 Hs 8850 a dismtegnn and metalloproteinase doma 140
453922 AF053306 Hs 36708 budding uninhibited by benzimidazo.es 1 138
436032 AA150797 Hs 109276 latexin protein 13 1
427585 D31152 Hs 179729 collagen, type X, alpha 1 (Schmid metaph 125
416661 AA634543 Hs 79440 IGF-II mRNA binding protein 3 122
414972 BE263782 Hs 77695 KIAA0008 gene product 106
445900 AF070526 Hs 13429 Homo sapiens clone 24787 mRNA sequence 105
446619 AU076643 Hs 313 sxreted phosphoprotein 1 (osteopondn, 10 5
441377 BE218239 Hs 202656 ESTs 102
419423 D26488 Hs 90315 KIAA0007 protein 98
415138 C18356 Hs 78045 dssue fxtor pathway inhibitor 2 96
424639 AI917494 Hs 131329 ESTs 94
412472 AW975398 Hs 293836 ESTs 92
447048 AW393080 Hs 228320 Homo sapiens cDNA FLJ23537 fis, one L 89
418379 AA218940 Hs 137516 fidgetiπ-like 1 88
423020 AA383092 Hs 1608 replication protein A3 (14kD) 86
408908 BE296227 Hs 48915 seπne/threon e kinase 15 85
419948 AB041035 Hs 93847 NAOPH oxidase 4 83
411750 BE562298 Hs 71827 KIAA0112 protein, homolog of yeast nbos 83
411479 AW848047 gb IL3-CT0214-291299-052-A12 CT0214 Homo 8 1
420900 AL045633 Hs 44269 ESTs 80
449347 AV649748 Hs 295901 ESTs 80 409041 AB033025 Hs 50081 KIAA1199 protein 80
450480 X82125 Hs 25040 zinc finger protein 239 76
417655 AA780791 Hs 14014 ESTs, Weakly similar to KIAA0973 protein 76
453878 AW964440 Hs 19025 ESTs 76
430403 AF039390 Hs 241382 tumor nxrosis fxtor (ligand) superfami 75
427961 AW293165 Hs 143134 ESTs 74
428330 L22524 Hs 2256 matnx metalloproteinase 7 (matπlysm, 73
426235 AI631964 Hs 34447 ESTs 71
452291 AF015592 Hs 28853 CDC7 (cell division cycle 7, S cerevisi 70
418205 L21715 Hs 83760 troponin 1. skeletal, fast 70
409757 NM 001898 Hs 123114 cystadn SN 69
430044 AA464510 Hs 152812 ESTs 66
444783 AK001468 Hs 62180 anillin (Drosophila Scraps homolog), xt 65
416209 AA236776 Hs 79078 MAD2 (mitodc aπest deficient, yeast, h 65
449020 AI621170 Hs 192699 ESTs 63
431958 X63629 Hs 2877 cadheπn 3, type 1, P-cadhenn (plxenta 58
434699 AA643687 Hs 149425 Homo sapiens cDNA F 11980 fis, clone HE 57
424345 AK001380 Hs 145479 Homo sapiens cDNA FU10518 fis, done NT 56
428227 AA321649 Hs 2248 small inducible cytokine subfamily B (Cy 54
434551 BE387162 Hs 280858 ESTs, Highly simila to XPB_HUMAN DNA-RE 53
427660 AI741320 Hs 114121 Homo sapiens cDNA FU23228 fis, clone C 50
424960 BE245380 Hs 153952 S nucleoddase (CD73) 49
400268 48
408427 AW194270 Hs 177236 ESTs 47
453785 AI368236 Hs 283732 ESTs 47
411274 NM_002776 Hs 69423 kallikrein 10 47
424717 H03754 Hs 152213 wingless-type MMTV mtegradon site fami 47
415752 BE314524 Hs 78776 putadve transmembrane protein 46
434370 AF130988 Hs 58346 downless (mouse) homolog 46
431806 AF186114 Hs 270737 tumor nxrosis fxtor (ligand) superfami 46
400205 46
422938 NM 001809 Hs 1594 centromere protein A (17kD) 45
406687 M31126 Hs 272620 pregnancy spxific beta-1-glycoproteιn 9 44
453160 AI263307 Hs 146228 ESTs 44
423871 AA331906 gb EST35805 Embryo, 8 week 1 Homo sapien 44
431211 M86849 Hs 5566 gap junction protein, beta 2, 26kD (conn 44
446638 AL133063 Hs 15783 Homo sapiens mRNA, cDNA DKFZp434P1115 (f 43
406741 AA058357 Hs 74466 carcmoembryonic antigen-related cell ad 43
411560 AW851186 gb IL3-CT0220-150200-071-H05 CT0220 Homo 4 1
433159 AB035898 Hs 150587 kinesm-like protein 2 41
446142 AI754693 Hs 145968 ESTs 4 1
414727 BE466904 gb hz28f03 x1 NCI_CGAP_GC6 Homo sapiens 4 1
422285 AI803103 gb tc14e06 x1 Soares NhHMPu.SI Homo sapi 41
451807 W52854 Hs 27099 DKFZP564J0863 protein 41
411558 AA102670 Hs 70725 gamma-aminobutync xid (GABA) A recepto 40
415701 NM 003878 Hs 78619 gamma-glutamyl hydrolase (coπjugase, fol 40
409420 Z15008 Hs 54451 laminin, gamma 2 (nicein (100kD), kalmi 39
452909 NM_015368 Hs 30985 pannexm 1 39
443211 AI128388 Hs 143655 ESTs 39
442896 R37725 Hs 261108 ESTs 38
407788 BE514982 Hs 38991 S100 calcium binding protein A2 38
406671 AA 129547 Hs 285754 met proto-oncogene (hepatxyte growth fa 38
421155 H87879 Hs 102267 lysyl oxidase 38
420552 AK000492 Hs 98806 hypothedcal protein 38
420727 H75701 Hs 99886 complement component 4-bιπdmg protein. 37
422665 AJ011812 Hs 119018 transcnpdon fxtor NRF 37
447425 AI963747 Hs 18573 xylphosphatase 1, erythrocyte (common) 37
417715 AW969587 Hs 86366 ESTs 37
406076 AL390179 Hs 137011 Homo sapiens mRNA, cDNA DKFZp547P134 (fr 36
452281 T93500 Hs 28792 Homo sapiens CDNA FU11041 fis, clone PL 36
412723 AA648459 Hs 179912 ESTs 36
452461 N78223 Hs 108106 transcπption fxtor 36
453331 AI240665 Hs 8895 ESTs 36
406434 36
417956 AA210704 Hs 190465 ESTs 36
410102 AW248508 Hs 279727 Homo sapiens cDNA FU14035 fis, clone HE 36
426471 M22440 Hs 170009 transforming growth fxtor, alpha 35
425782 U66468 Hs 159525 cell growth regulatory with EF-hand doma 35
442556 AL137761 Hs 8379 Homo sapiens mRNA, cDNA DKFZp586L2424 (f 35
426957 AA393676 Hs 97459 ESTs, Weakly similar to KIAA0819 protein 35
448105 AW591433 Hs 170675 ESTs, Weakly similar to TMS2.HUMAN TRANS 35
414998 NM 002543 Hs 77729 oxidised low density lipoprotein (Ixdn 35
442942 AW167087 Hs 131562 ESTs 34
416391 AI878927 Hs 79284 mesoderm spxific transcπpt (mouse) horn 34
420230 AL034344 Hs 298020 Homo sapiens cDNA FU11796 fis, clone HE 34
408243 Y0O787 Hs 624 interieukin 8 34
412978 AI431708 Hs 820 homeo box C6 34
412851 AI826502 Hs 106149 ESTs 34
417720 AA205625 Hs 208067 ESTs 34
414812 X72755 Hs 77367 monokine induced by gamma interferon 34
453884 AA355925 Hs 36232 KIAA0186 gene product 34
436396 AI683487 Hs 299112 Homo sapiens cDNA FU 11441 fis, clone HE 34
425921 NM.007231 Hs 162211 solute earner family 6 (neurotransmitte 34 420092 AA814043 Hs 88045 ESTs 33
423441 R68649 Hs 278359 absent in melanoma 1 like 33
421787 AA227068 Hs 108301 nuclear receptor subfamily 2, group C. 3 3
447342 AI199268 Hs 19322 ESTs 33
430178 AW449612 Hs 152475 ESTs 3 3
452826 BE245286 Hs 301636 ESTs, Moderately similar to PEX6.HUMAN P 33
414821 M63835 Hs 77424 Fc fragment of IgG, high affinity la, re 33
413339 AI818080 Hs 194290 ESTs 3 3
448756 AI739241 Hs 171480 ESTs 33
421948 L42583 Hs 111758 keradn 6A 33
431453 AW753917 gb RCO-CT0299-291199-031-F02 CT0299 Homo 3 3
438538 AA832203 Hs 291955 ESTs 33
439759 AL359055 Hs 67709 Homo sapiens mRNA full length insert cDN 33
431721 AB032996 Hs 268044 KIAA1170 protein 3 3
436391 AJ227892 Hs 146274 ESTs 33
442025 AW887434 Hs 11810 ESTs, Weakly similar to CD42 [C elegans 33
418007 M13509 Hs 83169 matnx metalloproteinase 1 (interstitial 32
411678 AI907114 Hs 71465 squalene epoxidase 32
422956 BE545072 Hs 122579 hypothedcal protein FU10461 32
450400 AI694722 Hs 279744 ESTs 32
453857 AL080235 Hs 35861 DKFZP586E1621 protein 32
423528 AB011137 Hs 129740 KIAA0565 gene product 32
440659 AF134160 Hs 7327 claudin 1 32
441085 AW136551 Hs 181245 Homo sapiens CDNA FU12532 fis, clone NT 32
412022 AI005043 Hs 24143 ESTs 3 2
418203 X54942 Hs 83758 CDC28 protein kinase 2 3 1
416111 AA033813 Hs 79018 chromadn assembly fxtor 1, subunit A ( 3 1
408633 AW963372 Hs 46677 PRO2000 protein 3 1
445808 AV655234 Hs 298083 ESTs 3 1
414618 AI204600 Hs 96978 ESTs 3 1
421340 F07783 Hs 1369 dxay axeleradng fxtor for complement 3 1
422689 AW856665 gb RC3-CT0297-290100-013O03 CT0297 Homo 3 1
456508 AA502764 Hs 123469 ESTs, Weakly similar to AF208855 1 BM-01 3 1
420759 T11832 Hs 127797 ESTs 3 1
452637 AW971231 Hs 291020 ESTs 3 1
415857 AA866115 Hs 301646 Homo sapiens cDNA FU11381 fis, clone HE 3 1
439451 AF086270 Hs 278554 heterochromadn like protein 1 3 1
424051 AL110203 Hs 138411 Homo sapiens mRN A, cDNA DKFZp586J 1922 (f 3 1
440138 AB033023 Hs 6982 hypothetical protein FU10201 3 1
454456 AW850984 gb IL3-CT0220-150200-068-H08 CT0220 Homo 30
429125 AA446854 Hs 271004 ESTs 30
408031 AA081395 Hs 42173 Homo sapiens cDNA FU10366 fis, clone NT 30
438394 BE379623 Hs 27693 CGI-124 protein 30
409361 NM 005982 Hs 54416 sine xulis homeobox (Drosophila) homolo 30
439453 BE264974 Hs 6566 thyroid hormone rxeptor interxtor 13 30
414696 AF002020 Hs 76918 Niemann-Pick disease, type C1 30
422746 NM.004484 Hs 119651 glypican 3 30
424947 R77952 Hs 239625 integral membrane protein 2B 30
453775 NM_002916 Hs 35120 replication fxtor C (xdvator 1) 4 (37 30
449386 AA001308 Hs 193213 ESTs 30
430687 BE274217 Hs 249247 heterogeneous nuclear protein similar to 29
428862 NM.000346 Hs 2316 SRY (sex-determining region Y)-box 9 (ca 29
401747 29
429682 NM 006306 Hs 211602 SMC1 (structural maintenance of chromoso 29
444735 BE019923 Hs 243122 hypothedcal protein FU 13057 similar to 29
413385 M34455 Hs 840 mdoleamine-pyrrole 2,3 dioxygenase 29
436222 AI208737 Hs 122810 Homosapιens cDNA FLJ11489fιs clone HE 29
442961 BE614474 Hs 289074 Homo sapiens cDNA FU13986 fis, clone Y7 29
454798 AW821295 gb PM3-ST0307-241299-002-g03 ST0307 Homo 29
421650 AA781795 Hs 122587 ESTs 29
434398 AA121098 Hs 3838 serum-inducible kinase 29
420153 N22120 Hs 75277 hypothedcal protein FU13910 29
435706 W31254 Hs 7045 GL004 protein 29
416065 BE267931 Hs 78996 proliferating cell nuclea andgen 29
423250 BE061916 Hs 125849 chromosome 8 open reading frame 2 28
423493 AI815965 Hs 129683 ubiquitm-coniugadng enzyme E2D 1 (homo 28
430242 U66669 Hs 236642 3-hydroxyιsobutyryl-Coenzyme A hydrolase 28
436411 AW674352 gb ba63c07 y1 NIH.MGC.12 Homo sapiens cD 28
411770 NM.014278 Hs 71992 heat shxk protein (hspl 10 family) 2 8
437834 AA769294 gb πz36g03 s1 NCI_CGAP_GCB1 Homo sapiens 28
400440 X83957 Hs 83870 nebul 28
444743 AA045648 Hs 11817 nudix (nucleoside diphosphale linked moi 28
428725 AI565937 Hs 98692 ESTs 28
417771 AA804698 Hs 82547 retinoic xid rxeptor responder (tazao 28
449420 AI654852 Hs 196562 ESTs, Highly similar to TS24 MOUSE PROTE 28
433929 AI375499 Hs 27379 ESTs 28
430287 AW182459 Hs 125759 ESTs, Weakly similar to tumor suppressor 28
423346 AI267677 Hs 127416 synaptojanin 1 28
407824 AA147884 Hs 9812 ESTs 28
408482 NM 000676 Hs 45743 adenosine A2b rxeptor 28
425188 AK002052 Hs 155071 hypothetical protein FU 11190 28
456999 AA319798 Hs 172247 eukaryotic transladon elongadon fxtor 28
408875 NM 015434 Hs 48604 DKFZP434B168 protein 28 407839 AA045144 Hs 161566 ESTs 27
409012 AU 17435 Hs 49725 DKFZP434I216 protein 27
410762 AF226053 Hs 66170 HSKM-8 protein 27
426925 NM 001196 Hs 172894 BH3 interxdng domain death agonist 27
410116 AW630671 Hs 58636 squamous cell carcinoma andgen recogniz 27
428398 AI249368 Hs 98558 ESTs 27
400048 AFFX control YEL002c/WBP1 27
412140 AA219691 Hs 73625 RAB6 interxdng, kinesm-like (rabkines 27
435664 AI032087 Hs 269819 ESTs 27
405695 27
456655 AI376736 Hs 111779 sxreted protein, xidic, cysteme-πch 27
408670 AF160967 Hs 46784 potassium large conductance calcium-xd 27
422576 BE548555 Hs 118554 CGI-83 protein 27
431379 AA504264 Hs 182937 peptidylprolyl isomerase A (cyclophilm 27
429540 M85776 gb EST02297 Fetal bran, Stratagene (cat 27
426874 N67325 Hs 247132 ESTs 27
433183 AF231338 Hs 222024 fraπscπptioπ fxtor BMAL2 27
409902 AI337658 Hs 156351 ESTs 27
422336 AI761322 Hs 115285 dihydrolipoamide S-xetyltransferase (E2 27
408434 AW195317 Hs 107716 Homo sapiens cDNA FU22344 fis, done H 27
432328 AI572739 Hs 195471 6-phosphofructo-2-kιnase/fructose-2,6-bι 27
407633 NM 007069 Hs 37189 simila to rat HREV107 26
419216 AU076718 Hs 164021 small inducible cytokine subfamily B (Cy 26
422363 T55979 Hs 115474 replication fxtor C (xdvator 1) 3 (38 26
445564 AB028957 Hs 12896 KIAA1034 protein 26
401644 26
417479 AI057052 Hs 133554 ESTs 26
434217 AW014795 Hs 23349 ESTs 26
426514 BE616633 Hs 301122 bone morphogenedc protein 7 (osteogenic 26
414800 BE538690 gb 601064676F1 NIH.MGCJ0 Homo sapiens c 26
400289 X07820 Hs 2258 matπx metalloproteinase 10 (stromelysm 26
418478 U38945 Hs 1174 cyclin-dependent kinase inhibitor 2A (me 26
421246 AW582962 Hs 300961 ESTs, Highly similar to AF151805 1 CGI-4 26
430397 AI924533 Hs 105607 ESTs 26
428048 AA705745 Hs 185070 ESTs 26
452092 BE245374 Hs 27842 hypothetical protein FU11210 26
440052 AI633744 Hs 195648 ESTs 26
433077 AA314262 Hs 289008 Homo sapiens cDNA FLJ21814 fis, ctone H 26
432407 AA221036 Hs 285026 HERV-H LTR-assxiating 1 26
452401 NM 007115 Hs 29352 tumor nxrosis fxtor, alpha-induced pro 26
451813 NM 016117 Hs 27182 phospholipase A2-xdvadng protein 26
410889 X91662 Hs 66744 twist (Drosophila) homolog (xrxephalos 26
440100 BE382685 Hs 158549 ESTs 26
413746 AA133243 Hs 171553 ESTs 26
414737 AI160386 Hs 125087 ESTs 26
422063 BE156476 gb QVO-HT0368-040100-082-C05 HT0368 Homo 26
418250 U29926 Hs 83918 adenosine monophosphate deaminase (isofo 26
437641 AA811452 Hs 291911 ESTs 26
436027 AI864053 Hs 39972 ESTs, Weakly similar to I38588 reverse t 26
444381 BE387335 Hs 283713 ESTs, Weakly similar to CA54 HUMAN COLLA 26
452571 W31518 Hs 34665 ESTs 26
452862 AW378065 Hs 8687 ESTs 26
411984 NM 005419 Hs 72988 signal transducer and xdvator of trans 26
446440 AV658411 Hs 42656 Homo sapiens cDNA FLJ12667 fis, clone NT 26
448663 BE614599 Hs 106823 H sapiens gene from PAC 426I6, similar t 26
426427 M86699 Hs 169840 TTK protein kinase 26
445848 AA774824 Hs 13377 Homo sapiens ctone 23649 and 23755 unkno 26
420022 AA256253 Hs 120817 ESTs 26
451418 BE387790 Hs 26369 hypothetical protein FU20287 26
428953 AA306610 Hs 194676 DKFZP434C013 protein 26
424008 R02740 Hs 137555 putative chemokine rxeptor, GTP-binding 26
417863 AB000450 Hs 82771 vaccinia related kinase 2 26
414987 AA524394 Hs 165544 ESTs 26
440249 AI246590 Hs 125325 ESTs 26
407966 AA295052 Hs 38516 ESTs 25
406685 M18728 gb Human noπspxific crossrexting antig 25
403204 25
436961 AW375974 Hs 156704 ESTs 25
422260 AA315993 Hs 105484 ESTs, Weakly simila to UTB_HUMAN LITHO 25
444471 AB020684 Hs 11217 KIAA0877 protein 25
430290 AI734110 Hs 136355 ESTs 25
413670 AB000115 Hs 75470 hypothetical protein, expressed in osteo 25
421928 AF013758 Hs 109643 polyadenylate binding protein-interxtin 25
439580 AF086401 Hs 293847 ESTs 25
439963 AW247529 Hs 6793 platelet-xdvadng fxtor xetylhydrola 25
457065 AI476318 Hs 192480 ESTs 25
439521 AI808955 Hs 58248 ESTs 25
426711 AA383471 Hs 180669 conserved gene amplified in osteosarcoma 25
422631 BE218919 Hs 118793 hypothedcal protein FU10688 25
417866 AW067903 Hs 82772 collagen, type XI, alpha 1 25
416975 NM 004131 Hs 1051 granzyme B (granzyme 2, cytotoxic T-lymp 25
415947 U04045 Hs 78934 mutS (E coli) homolog 2 (colon cancer, 25
454678 AW813089 gb RC3-ST0186-240400- 111 -b05 ST0186 Homo 25 424080 AW189983 Hs 139119 Homo sapiens cDNA FU10967 fis, clone PL 25
426572 AB037783 Hs 170623 hypothedcal protein FU11183 25
440594 AW445167 Hs 126036 ESTs 25
428264 AA424839 Hs 98484 ESTs, Weakly similar to ALU1.HUMAN ALU S 25
408750 BE294069 Hs 93581 hypothedcal protein FU10512 25
451177 AI969716 Hs 13034 ESTs 25
449318 AW236021 Hs 108788 ESTs, Weakly simila to zeste (D melanog 25
434414 AI798376 gb tr34b07 x1 NCI_CGAP_0v23 Homo sapiens 25
400240 25
410519 AW612264 Hs 131705 ESTs 25
440953 AI683036 Hs 124135 KIAA1618 protein 25
421190 U95031 Hs 102482 mucin 5, subtype B, trxheobronchial 25
444478 W07318 Hs 240 M-phase phosphoprotein 1 25
442295 AI827248 Hs 224398 Homo sapiens cDNA FU 11469 fis, clone HE 25
420894 AA744597 Hs 88854 ESTs 25
410094 BE147897 Hs 58593 general transcnption fxtor IIF, polype 24
413998 AW103807 Hs 243933 ESTs 24
412281 AI810054 Hs 14119 ESTs 24
418105 AW937488 Hs 178000 ESTs 24
447335 BE617695 Hs 286192 protein phosphatase 1, regulatory (inhib 24
446852 AW451643 Hs 257479 ESTs, Weakly similar to AF147747 1 BOG25 24
408915 NM 016651 Hs 48950 heptacellular cac oma novel gene-3 pro 24
442991 BE281238 Hs 8886 hypothedcal protein FU20424 24
410193 AJ132592 Hs 59757 zinc finger protein 281 24
410664 NM.006033 Hs 65370 lipase, endothelial 24
449264 AI637649 Hs 196105 ESTs 24
423453 AW450737 Hs 128791 CGI-09 protein 24
433757 AI949974 Hs 152670 ESTs 24
411598 BE336654 Hs 70937 H3 histone family, member K 24
431657 AI345227 Hs 105448 ESTs, Weakly similar to B34087 hypothed 24
429663 M68874 Hs 211587 phospholipase A2, group IVA (cytosolic, 24
428242 H55709 Hs 2250 leukemia inhibitory fxtor (cholmergic 24
419559 Y07828 Hs 91096 πng finger protem 24
419839 U24577 Hs 93304 phospholipase A2, group VII (platelet-x 24
419713 AW968058 Hs 92381 nudix (nucleoside diphosphate linked moi 24
413281 AA861271 Hs 34396 ESTs 24
402819 24
431457 NM 012211 Hs 256297 integnn, alpha 11 24
422564 AI148006 Hs 222120 ESTs 24
443683 BE241717 Hs 9676 uncharxteπzed hypothalamus protein HT0 24
407242 M18728 gb Human nonspxific crossrexdng andg 24
409235 AA188827 Hs 7988 ESTs, Weakly similar to endo-alpha-D-man 24
408938 AA059013 Hs 22607 ESTs 24
422158 L10343 Hs 112341 protease inhibitor 3, skm-denved (SKAL 24
423217 NM 000094 Hs 1640 collagen, type VII, alpha 1 (epidermolys 24
408321 AW405882 Hs 44205 cortistatm 24
419086 NM 000216 Hs 89591 Kallmann syndrome 1 sequence 24
452945 AW978187 Hs 31086 Homo sapiens mRNA for cytxhrome b5, pa 24
452234 AW084176 Hs 223296 ESTs 24
427722 AK000123 Hs 180479 hypothedcal protein FU20116 24
430399 AI916284 Hs 199671 ESTs 24
450737 AW007152 Hs 203330 ESTs 24
428513 BE220806 Hs 184697 Homo sapiens clone 23785 mRNA sequence 24
405454 24
422168 AA586894 Hs 112408 S100 calcium-binding protein A7 (psonas 23
421462 AF016495 Hs 104624 aquapoπn 9 23
403416 AI744626 Hs 301506 ESTs, Highly similar to KIAA0564 protein 23
422039 BE567832 Hs 82148 hypothedcal protein 23
448988 Y09763 Hs 22785 gamma-aminobutync xid (GABA) A recepto 23
429145 AI694923 Hs 49031 ESTs 23
423198 M81933 Hs 1634 cell division cycle 25A 23
442914 AW188551 Hs 99519 Homo sapiens cDNA FU14007 fis, clone Y7 23
449042 AW294985 Hs 301148 potassium voltage-gated channel, Isk-rel 23
421308 AA687322 Hs 192843 ESTs 23
419926 AW900992 Hs 93796 DKFZP586D2223 protein 23
429992 AL050053 Hs 227397 Homo sapiens mRNA, cDNA DKFZp566E103 (fr 23
440601 N62409 Hs 126688 ESTs 23
446232 AI281848 Hs 165547 ESTs 23
410174 AA306007 Hs 59461 DKFZP434C245 protein 23
452110 T47667 Hs 28005 Homo sapiens mRNA, cDNA DKFZp564G2463 (f 23
422493 AW474183 Hs 233816 ESTs 23
407047 X65965 gb H sapiens SOD-2 gene for manganese su 23
411096 U80034 Hs 68583 mitxhondnal intermediate pepddase 23
426457 AW894667 Hs 169965 chime m (chimxnn) 1 23
442029 AW956698 Hs 14456 neural precursor cell expressed, develop 23
446545 AI431798 Hs 164192 ESTs Weakly similar to Y161_HUMAN HYPOT 23
422094 AF129535 Hs 272027 F-box only protein 5 23
421933 R98881 Hs 109655 sex comb on midleg (Drosophιla)-lιke 1 23
430001 AI580056 Hs 98992 ESTs 23
420802 U22376 Hs 1334 v-myb avian myeloblastosis viral oncogen 23
402053 23
415666 H72693 gb yu03c11 r1 Soares fetal liver spleen 23
432743 AI146966 Hs 101656 ESTs 23 433409 AI278802 Hs 25661 ESTs 23
408330 AW182602 Hs 249954 ESTs 23
407807 AL031427 Hs 40094 Human DNA sequence from ctone 167A19 on 23
436972 AA284679 Hs 25640 claudin 3 23
436747 AW977192 Hs 291343 ESTs 23
433730 AK002135 Hs 3542 hypothedcal protein FU11273 23
414839 X63692 Hs 77462 DNA (cytosιne-5-)-methyltransferase 1 23
438192 AI859065 Hs 16808 ESTs, Weakly similar to paraplegm-like 23
415339 NM 015156 Hs 78398 KIAA0071 protein 23
449539 W80363 Hs 58446 ESTs 22
412651 AA115333 Hs 107968 ESTs 22
450956 AW193531 Hs 205647 ESTs, Moderately similar to ALU1.HUMAN A 22
430335 D80O07 Hs 239499 KIAA0185 protein 22
417849 AW291587 Hs 82733 nidogen 2 22
454946 AW846376 gb QVO-CT0179-090200-090-.09 CT0179 Homo 22
412326 R07566 Hs 73817 small inducible cytokine A3 (homologous 22
408349 BE546947 Hs 44276 hom∞ box C10 22
424704 AI263293 Hs 152096 cytxhrome P450, subfamily IIJ (axhido 22
419433 AA814807 Hs 7395 hypothetical protein FU23182 22
409632 W74001 Hs 55279 senne (or cysteine) proteinase mhibito 22
415323 BE269352 Hs 949 neutrophil cytosolic fxtor 2 (65kD, chr 22
417531 NM_003157 Hs 1087 seπne/threonine kinase 2 22
403137 22
428479 Y00272 Hs 184572 cell division cycle 2, G1 to S and G2 to 22
430200 BE613337 Hs 234896 geminin 22
433745 AF075320 Hs 28980 Homo sapiens clone HQ0270 22
425390 AI092634 Hs 156114 protein tyrosine phosphatase, non-rxept 22
408380 AF123050 Hs 44532 diubiquidn 22
422424 AI186431 Hs 116577 prostate differentiation fxtor 22
431548 AI834273 Hs 9711 Homo sapiens cDNA FU13018 fis, clone NT 22
400298 AA032279 Hs 61635 six transmembrane epithelial antigen of 22
428771 A8028992 Hs 193143 KIAA1069 protein 22
411571 AA122393 Hs 70811 hypothedcal protein FU20516 22
442573 H93366 Hs 7567 Homo sapiens cDNA FLJ21962 fis, clone H 22
412802 U41518 Hs 74602 aquaponn 1 (channel-forming integral pr 22
412530 AA766268 Hs 266273 Homo sapiens cDNA FU13346 fis, clone OV 22
414761 AU077228 Hs 77256 enhancer of zeste (Drosophila) homolog 2 22
408432 AW195262 gb xn67b05 x1 NCI CGAP CML1 Homo sapiens 22
440283 AI732892 Hs 190489 ESTs 22
429568 AI088691 Hs 208414 Homo sapiens mRNA, cDNA DKFZp564D0472 (f 22
424003 BE274717 Hs 137506 Homo sapiens BAC clone RP11-120J2 from 7 22
425300 AW601773 Hs 270259 ESTs 22
448568 AA149121 Hs 71947 ESTs 22
419229 AI827237 Hs 282884 ESTs 22
420982 AW576160 Hs 100729 KIAA0692 protein 22
403258 22
439653 AW021103 Hs 6631 hypothedcal protein FLJ20373 22
426827 AW067805 Hs 172665 methylenetetrahydrofolate dehydrogenase 22
444514 AI682905 Hs 270431 ESTs, Weakly similar to ALU1_HUMAN ALU S 22
426298 AW965058 Hs 111583 ESTs 22
425322 U63630 Hs 155637 protein kinase, DNA-xdvated, catalytic 22
421662 NM.014141 Hs 106552 cell recognidon molxule Caspr2 22
412505 AA974491 Hs 21734 ESTs 22
438788 AA825716 gb od29e10 s1 NCI_CGAP_GCB1 Homo sapiens 22
429058 AF138863 Hs 194827 hypothedcal protein FLB6421 22
423104 AJ005273 Hs 123647 andgenic determinant of recA protein (m 22
410406 AI969703 Hs 301842 ESTs 22
443180 R15875 Hs 70945 ESTs 22
419235 AW470411 Hs 288433 neurotπmin 22
421379 Y15221 Hs 103982 small inducible cytokine subfamily B (Cy 22
422809 AK001379 Hs 121028 hypothedcal protein FU 10549 22
415058 AW902848 Hs 273829 ESTs 22
418049 AA211467 Hs 190488 hypothedcal protein FU10120 22
436209 AW850417 Hs 254020 ESTs, Moderately similar to unnamed prot 22
408042 AL049233 Hs 42244 Homo sapiens mRNA, cDNA DKFZp564A023 (tr 22
425692 D90041 Hs 155956 N-xetyltransferase 1 (arylamine N-xety 22
409665 NM.006731 Hs 55777 Fukuyama type congenital muscular dystro 22
428157 AI738719 Hs 298668 ESTs 22
410480 R97457 Hs 63984 cadhenn 13, H-cadheπn (heart) 22
429732 U20158 Hs 2488 lymphxyte cytosolic protein 2 (SH2 doma 22
414747 U30872 Hs 77204 centromere protein F (350/400kD. mitosin 22
425843 BE313280 Hs 159627 death assxiated protein 3 22
445299 AI910382 Hs 118727 Homo sapiens cDNA FLJ 13692 fis, clone PL 21
436251 BE515065 Hs 5092 nucleolar protein (KKE/D repeat) 21
430066 AI929659 Hs 237825 signal recognition particle 72kD 21
422516 BE258862 Hs 117950 muldfunctional polypepdde similar to S 21
407870 AB032990 Hs 0719 hypothetical protein KIAA1164 21
416109 AI420311 Hs 126550 suppressor of K+ transport detect 1 21
427528 AU077143 Hs 179565 minichromosome maintenance deficient (S 21
448089 AI467945 Hs 173696 ESTs 21
441790 AW294909 Hs 132208 ESTs 21
400022 AFFX control STAT1 21
428728 NM.016625 Hs 191381 hypothetical protein 21 414366 BE549143 gb 601076456F1 NIH.MGC.12 Homo sapiens c 21
409929 R38772 Hs 172619 KIAA1106 protein 2 1
405264 21
445625 BE246743 Hs 288529 Homo sapiens cDNA FU22635 fis clone H 2 1
408949 AF189011 Hs 49163 putadve ribonuclease III 2 1
424513 BE385864 Hs 149894 mitochondrial translational initiation f 2 1
433683 AI817723 Hs 22678 hypothedcal protein FU21832 2 1
442952 AI743261 Hs 131860 ESTs 2 1
441020 W79283 Hs 35962 ESTs 2 1
446770 AV660309 Hs 154986 ESTs, Weakly similar to AF137386 1 plasm 2 1
432378 AI493046 Hs 146133 ESTs 2 1
447769 AW873704 Hs 48764 ESTs 2 1
412654 AI093480 Hs 29263 Homo sapiens cONA FLJ11896 (is, clone HE 2 1
445669 AI570830 Hs 174870 ESTs 2 1
417979 AU077284 Hs 83081 GTP cyclohydrolase 1 feedbxk regulatory 21
433849 BE465884 Hs 280728 ESTs 21
437928 NM 005476 Hs 5920 UOP-N-acety(glucosamme-2-epιmerase/N-x 21
457341 BE181716 gb QV1-HT0639-150500-198<03 HT0639 Homo 21
452833 BE559681 Hs 30736 KIAA0124 protein 21
403055 2 1
414581 AA256213 Hs 72010 ESTs 2 1
432840 AK001403 Hs 279521 hypothedcal protein FU20530 21
418994 AA296520 Hs 89546 selxdn E (endothelial adhesion molxul 2 1
440908 AI915225 Hs 126735 ESTs 21
417621 AV654694 Hs 82316 interferon-induced. hepatitis C-associat 21
436895 AF037335 Hs 5338 cartraπic aπhydrase XII 2 1
455716 BE070263 gb QV4-BT0407-280100-090-eO7 BT0407 Homo 2 1
408420 NM 006915 Hs 299481 Homo sapiens mRNA cDNA DKFZp586B0118 (f 21
435849 BE305242 Hs 112442 ESTs, Weakly similar to CLDE.HUMAN CLAUD 2 1
424308 AW975531 Hs 154443 minichromosome mantenance deficient (S 2 1
433644 AW342028 Hs 256112 ESTs 2 1
400020 AFFX control STAT1 2 1
434064 AL049045 Hs 180758 hypothetical protein PRO0082 21
410660 AI061118 Hs 65328 Fancom anemia complementation group F 2 1
404076 2 1
441362 BE614410 Hs 23044 RAD51 (S cerevisiae) homolog (E cod Re 2 1
422515 AW500470 Hs 117950 multifunctional polypepdde similar to S 2 1
444863 AW384082 Hs 301323 ESTs 2 1
445867 AF272663 Hs 13405 gephynn 21
441021 AW578716 Hs 7644 H1 histone family, member 2 2 1
446595 T57448 Hs 15467 hypothetical protein FU20725 2 1
417515 L24203 Hs 82237 ataxia-telangixtasia group D-assxiated 2 1
412429 AV650262 Hs 75765 GR02 oncogene 2 1
449207 AL044222 Hs 23255 nucleopoπn 155kD 2 1
412095 AI624707 Hs 5921 Homo sapiens cDNA FLJ21592 fis clone C 2 1
400861 2 1
448826 AI580252 Hs 293246 ESTs, Weakly similar to putative p150 (H 2 1
440591 AA431599 Hs 132799 Homo sapiens cDNA FU23451 fis, clone H 2 1
426181 AA371422 Hs 69844 ESTs, Weakly simila to dJ191N21 1 [H sa 21
452880 AA029332 Hs 87549 ESTs 21
421878 AA299652 Hs 111496 Homo sapiens cDNA FU 11643 fis, clone HE 2 1
442104 1-20971 Hs 188 phosphodiesterase 4B, cAMP-spxific (dun 21
427224 AL135554 Hs 101937 sine xulis homeobox (Drosophila) homolo 2 1
446921 AB012113 Hs 16530 small inducible cytokine subfamily A (Cy 21
432487 AA550988 Hs 221472 ESTs 21
429534 AW976987 Hs 163327 ESTs 2 1
446051 BE048061 Hs 153315 ESTs 21
447760 AI431328 Hs 291179 ESTs, Weakly simila to topoisomerase I 2 1
422675 BE018517 Hs 119140 eukaryotic translation initiation fxtor 2 1
415173 AW501735 Hs 253015 ESTs 21
425170 AU077315 Hs 154970 transcnpdon fxtor CP2 2 1
453751 R36762 Hs 101282 Homo sapiens mRNA, cDNA DKFZp434B102 (fr 21
426283 NM 003937 Hs 169139 kynurenmase (L-kynurenme hydrolase) 2 1
417874 BE616160 Hs 82829 protein tyrosine phosphatase, non-rxept 21
449555 AW450288 Hs 195390 ESTs 2 1
439699 AF086534 Hs 187561 ESTs, Moderately similar to ALU1.HUMAN A 2 1
427413 BE547647 Hs 177781 superoxide dismutase 2, mitxhondnal 2 1
424673 AA345051 Hs 294092 ESTs 2 1
407802 D84145 Hs 39913 novel RGO-contaning protein 20
452834 AI638627 Hs 105685 ESTs 20
438895 AW007021 Hs 82894 ESTs 20
446035 NM 006558 Hs 13565 Sam68-lιke phosphotyrosine protein, T-ST 20
406981 S71129 Hs 296844 Acetylcholinesterase (I4-E5 doman) [huma 20
427001 NM 006482 Hs 173135 dual-spxificity tyrosme-(Y)-phosphoryl 20
439223 AW238299 Hs 23945 ESTs 20
432343 NM 002960 Hs 2961 SlOOcalcium-biπdmg protein A3 20
414890 BE281095 Hs 77573 undine phosphoiylase 20
423019 AI640185 Hs 225816 ESTs 20
435905 AW997484 Hs 5003 KIAA0456 protein 20
422278 AF072873 Hs 114218 frizzled (Drosophila) homolog 6 20
439608 AW864696 Hs 26198 Homo sapiens cDNA FU23363 fis, clone H 20
432114 AL036021 Hs 225597 ESTs 20
405545 20 418201 AA214345 Hs 98445 Homo sapiens cDNA FU21652 fis, clone C 20
442528 AF150317 Hs 134217 ESTs 20
446237 AW270515 Hs 149596 ESTs 20
428074 BE387770 Hs 182378 colony sdmulatmg fxtor 2 rxeptor, al 20
423430 AF112481 Hs 128501 RAD54, S cerevisiae, homolog of B 20
435767 H73505 Hs 117874 ESTs 20
432945 AL043683 Hs 271357 ESTs, Weakly similar to unnamed protein 20
428792 BE535955 Hs 193602 chromosome condensation protein G 20
404170 20
410286 AI739159 Hs 61898 DKFZP586N2124 protein 20
434565 T52172 gb yb22d01 s1 Stratagene fetal spleen (9 20
422610 AF153820 HS 1547 potassium mwardly-recdfyiπg channel, s 20
417933 X02308 Hs 82962 thymidylate synthetase 20
441384 AA447849 Hs 288660 protease, senne, 23 20
437403 AI208149 Hs 121196 ESTs 20
412673 AL042957 Hs 31845 ESTs 20
414020 NM 002984 Hs 75703 small inducible cytokine A4 (homologous 20
438426 AA835936 Hs 269763 ESTs 20
413943 AW294416 Hs 144687 ESTs 20
449001 AI619957 Hs 189854 ESTs 20
427674 NM 003528 Hs 2178 H2B histone family, member Q 20
435425 H16263 Hs 31416 ESTs 20
433364 AI075407 Hs 296083 ESTs 20
429782 NM 005754 Hs 220689 Ras-GTPase-xdvadng protein SH3-doman 20
417366 BE185289 Hs 1076 small prolme-πch protein 1B (comifin) 20
426746 J03626 Hs 2057 undine monophosphate synthetase (orotat 20
411943 BE502436 Hs 7962 ESTs, Weakly similar to putadve [C eleg 20
414266 BE267834 gb 601124428F1 NIH.MGC.8 Homo sapiens cD 20
432677 NM 004482 Hs 278611 UDP-N-xetyl-alpha-D-galxtosamine polyp 20
450534 AI570189 Hs 25132 KIAA0470 gene product 20
446715 AI337735 Hs 173919 ESTs 20
TABLE 42B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank axession numbers
Pkey CAT number Axession
408432 1058667.1 AW195262 R27868AW811262
411479 1247077.1 AW848047 AW848202 AW848631 AW848142 AW848702 AW848121 AW848632 AW848140 AW848571 AW848009 AW848067 AW848069 AW848905
AW848214
411560 1249443.1 AW851186 AW996967 BE143456 414266 1430984.1 BE267834 BE514180 BE514096 414366 1438636.1 BE549143 BE390613 BE277344 414727 1481204.1 BE466904W28721 414800 1491863.1 BE538690T40217 415666 1543492.1 H72693 R08673 H72694 F20990 R08580 422063 210852.1 BE156476 BE156473 BE156474 BE156475AA302839 422285 214669.1 AI803103 AI885143 AW470793 AW450703 AI090784 AW271587 AW236950 AW242783 422689 219896.1 AW856665 AA315006 AW954733 423871 232749.1 AA331906 AA332484 429540 305828.1 M85776 AA454535 AA456208 H90189 431453 333457.1 AW753917 BE152926 AA505333 BE155673 434414 38585.1 AI798376 S46400 AW811617 AW811616 W00557 BE142245 AW858232 AW861851 AW858362 AA232351 AA218567 AA055556 AW858231
AW857541 AW814172 H66214 AW814398 AF134164 AA243093 AA173345 AA199942 AA223384 AA227092 AA227080 T12379 AA092174 T61139
AA149776 AA699829 AW879188 AW813567 AW813538 AI267168 AA157718 AA157719 AA100472 AA100774 AA130756 AA157705 AA157730
AA157715 AA053524 AW849581 AW854566 C05254 AW882836 T92637 AW812621 AA206583 AA209204 BE156909 AA226824 AI829309 AW991957
N66951 AA527374 H66215 AA045564 AI694265 H60808 AA149726 AW195620 BE081333 BE073424 AW817662 AW817705 AW817703 AW817659
BE081531 H59570
434565 38898 1 T52172 AF147324 T52248 436411 419334.1 AW674352 AA715374 Z25205 437834 443674.1 AA769294 AW749299 AW749302 AW749295 AW749304 AW749293 AW749298 AW749294 AW749288 AW749291 AW749297 AW749292 AW749296
AW749289 AW7492878E535498
438788 465159.1 AA825716 AW978859 AA828841 454456 1207088.1 AW850984 AW752836 M86124 454678 1228915.1 AW813089W28102 454798 1235104.1 AW821295 AW821272 AW821282 454946 1245753.1 AW846376 AW846375 AW846434 AW846287 AW846365 AW846554 AW846384 AW846290 AW846356 AW846474 455716 1352695.1 BE070263 BE070195 BE070265 BE070202 BE070233 BE070399 BE070203 457341 322221 1 BE181716 AW948314 AW801848 AW948320 AW983981 AA484444
TABLE 42C
Pkey Unique number conesponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column ae Genbank Idendfier (Gl) numbers "Dunham, et al * refers to the publication endtled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposidon Indicates nudeodde positions of predicted exons
Pkey Ref Strand NLposition 400861 9757506 Plus 163855-164016
401644 8576138 Plus 82655-83959
401747 9789672 Minus 118596-118816,119119-119244,119609-119761,120422-120990,130161-130381,130468-130593.131097-131258,131866-31932132451-
132575,133580-134011 402053 8083229 Plus 62703-63179
402819 6729581 Plus 29217-29422
403055 8748904 Minus 109532-110225
403137 9211494 Minus 92349-92572,92958-93084,93579-93712,93949-94072,94591-94748.95214-95337
403204 7622392 Plus 16214-16439
403258 7770439 Minus 156251-156619
403776 7770611 Minus 1414-1513,1624-1756
404076 9931752 Minus 3848-3967
404170 9930793 Plus 168836-169248
405264 7329374 Plus 28556-28684
405454 7656675 Plus 133807-134053
405545 1054740 Plus 118677-118807,119091-119296,121626-121823
405695 4309958 Plus 51860-52162
406434 9256651 Minus 17803-17931
TABLE 43A ABOUT 339 GENES UP-REGULATED IN STOMACH CANCER
Table 43A lists about 339 genes up-regulated in stomxh cancer compared to normal stomxh that are likely to be extrxellular or cell-surface proteins These were selxted as for Table 42A and the predicted protein contained a structural domain that is indicadve of surfxe or extrxellular Ixalizadon (e g ig, fn3, egf, 7tm domains) Predicted protein domains are noted
Pkey Unique Eos probeset idendfier number
ExAxn Exemplar Axession number, Genbank aα
UnigenelD Unigene number
Unigene Title Unigene gene dtle
PSDoman Protein Structural Doman
R1 Ratio of tumor to normal dssue
Pkey ExAxn UnigenelD Unigene Tide PSDoman R1
428368 BE440042 Hs 83326 matnx metallop hemopexιn,Pepddase_M10„SS 604
428664 AK001666 Hs 189095 similar to SALL zf-C2H2,TM,SS 268
422330 D30783 Hs 115263 epiregulm EGF.TM SS 220
439979 AW600291 Hs 6823 hypothedcal pr TM 190
451099 R52795 Hs 25954 interieukin 13 fn3,TM,SS 171
403776 IL8.TM.SS 149
424905 NM 002497 Hs 153704 NIMA (never in pkinase.TM, 148
453922 AF053306 Hs 36708 budding uniπhib TM 138
436032 AA150797 Hs 109276 latexin protein TM 131
427585 D31152 Hs 179729 collagen, type C1q,Collagen,TM SS 125
416661 AA634543 Hs 79440 IGF-II mRNA-bin KH-doman TM, 122
414972 BE263782 Hs 77695 KIAA0008 gene p TM 106
446619 AU076643 Hs 313 sxreted phosph Osteopondn.TM SS 105
415138 C18356 Hs 78045 dssue fxtor p Kunitz.BPTI G-gamma TM SS 96
423020 AA383092 Hs 1608 replicadon pro TM 86
408908 BE296227 Hs 48915 seπne/threonm pkinase.TM SS 85
419948 AB041035 Hs 93847 NADPH oxidase 4 Ferπc.reduct TM SS 83
411750 BE562298 Hs 71827 KIAA0112 protei SS 83
420900 AL045633 Hs 44269 ESTs Ald_Xan_dh.C.FAD_bιndιng_5,TM, 80
450480 X82125 Hs 25040 zinc finger pro zf-C2H2 TM,SS 76
417655 AA780791 Hs 14014 ESTs, Weakly si TM 76
430403 AF039390 Hs 241382 tumor nxrosis TM.SS 75
428330 L22524 Hs 2256 matnx metallop Pepddase_M10„SS 73
452291 AF015592 Hs 28853 CDC7 (cell ivi pkinase.TM, 70
418205 L21715 Hs 83760 troponin I, ske Troponιn„SS 70
409757 NM 001898 Hs 123114 cystadπ SN cystatιn„SS 69
444783 AK001468 Hs 62180 anillm (Drosop PHJM, 65
416209 AA236776 Hs 79078 MAD2 (mitodc a HORMA„SS 65
431958 X63629 Hs 2877 cadheπn 3, typ cadhenn,Cadhenn_C_term TM.SS 58
424345 AK00138O Hs 145479 Homo sapiens cD TM.SS 56
428227 AA321649 Hs 2248 small inducible IL8.TM.SS 54
424960 BE245380 Hs 153952 5' nucleoddase 5_nuclxddase,TM,SS 49
400268 Myosm_taιl„SS 48
411274 NM 002776 Hs 69423 kallikrein 10 trypsin.TM, 47
415752 BE314524 Hs 78776 putadve transm TM 46
431806 AF186114 Hs 270737 tumor nxrosis TM.SS 46
400205 SS 46
422938 NM 001809 Hs 1594 centromere prot histone.TM 45
406687 M31126 Hs 272620 pregnancy spxi hemopexin.TM, 44
423871 AA331906 gb EST35805 Emb TM 44
431211 M86849 Hs 5566 gap juncdon pr connexin.TM, 44
446638 AL133063 Hs 15783 Homo sapiens mR TM 43
406741 AA058357 Hs 74466 carcinoembryoni ig.TM.SS 43
411560 AW851186 gb IL3-CT0220-1 TM 41
433159 AB035898 Hs 150587 kinesm-like pr kinesin Myosm.tail.TM SS 41
422285 AI803103 gb tc14e06 1 S TM.SS 41
451807 W52854 Hs 27099 OKFZP564J0863 p TM 41
411558 AA102670 Hs 70725 gamma-ammobuty neur_chan,TM,SS 40
415701 NM 003878 Hs 78619 gamma-glutamyl TM.SS 40
409420 Z15008 Hs 54451 laminin, gamma laminin.EGF.Iammin.B ,SS 39
452909 NM 015368 Hs 30985 pannexm 1 TM 39
407788 BE514982 Hs 38991 S100 calcium-bi efhand,S_100,TM,SS 38
421155 H87879 Hs 102267 lysyl oxidase Lysyl_oxιdase„SS 38
420552 AK00O492 Hs 98806 hypothetical pr SS 38
420727 H75701 Hs 99886 complement ∞mp sushi,, 37 422665 AJ011812 Hs 119018 transcnpdon f R3H,G-patch,GTP.CDC,TM,SS 37
447425 AI963747 Hs 18573 acylphosphatase Acylphosphatase.TM, 37
406076 AL390179 Hs 137011 Homo sapiens mR TM 36
406434 heme_1,TM, 36
417956 AA210704 Hs 190465 ESTs sushi, ,SS 36
410102 AW248508 Hs 279727 Homo sapiens cD TM.SS 36
426471 M22440 Hs 170009 transforming gr EGF.TM.SS 35
425782 U66468 Hs 159525 cell growth reg SS 35
426957 AA393676 Hs 97459 ESTs, Weakly si SS 35
448105 AW591433 Hs 170675 ESTs, Weakly si hγpsin.TM, 35
414998 NM 002543 Hs 77729 oxidised low de TM 35
442942 AW167087 Hs 131562 ESTs pkmase.TM.SS 34
416391 AI878927 Hs 79284 mesoderm spxif abhydrdase.TM.SS 34
420230 AL034344 Hs 298020 Homo sapiens cO Fork head.TM, 34
408243 Y00787 Hs 624 interieukin 8 IL8.TM.SS 34
412978 AI431708 Hs 820 homeo box C6 hom∞box.TM, 34
412851 AI826502 Hs 106149 ESTs TM.SS 34
414812 X72755 Hs 77367 monokine induce IL8..SS 34
453884 AA355925 Hs 36232 KIAA0186 gene p TM 34
425921 NM 007231 Hs 162211 solute earner SNFJM, 34
421787 AA227068 Hs 108301 nuclear recepto TM 33
447342 AI199268 Hs 19322 ESTs TM.SS 33
452826 BE245286 Hs 301636 ESTs, Moderatel AAAJM, 33
414821 M63835 Hs 77424 Fc fragment of ιg,TM,SS 33
448756 AI739241 Hs 171480 ESTs TM 33
421948 L42583 Hs 111758 keradn 6A filamenLTM, 33
438538 AA832203 Hs 291955 ESTs TM 33
436391 AJ227892 Hs 146274 ESTs SS 33
418007 M13509 Hs 83169 matπx metallop hemopexιn,Peptιdase_M10„SS 32
411678 AI907114 Hs 71465 squalene epoxid Moπ∞xygenase.TM, 32
422956 BE545072 Hs 122579 hypothetical pr TM 32
450400 AI694722 Hs 279744 ESTs TM 32
440659 AF134160 Hs 7327 claudin 1 PMP22 Claudιn,TM,SS 32
418203 X54942 Hs 83758 CDC28 protein k CKS.TM, 31
416111 AA033813 Hs 79018 chromadn assem TM.SS 31
445808 AV655234 Hs 298083 ESTs sushi.TM.SS 3 1
421340 F07783 Hs 1369 dxay axelerat sushι„SS 31
422689 AW856665 gb RC3-CT0297-2 SNF2.N.TM, 3 1
439451 AF086270 Hs 278554 heterxhromadn chromo.Chromo shadow„SS 31
454456 AW850984 gb IL3-CT0220-1 fn3,TM,SS 30
429125 AA446854 Hs 271004 ESTs TM 30
409361 NM 005982 Hs 54416 sine oculis horn homxbox„SS 30
439453 BE264974 Hs 6566 thyroid hormone AAAJM, 30
414696 AF002020 Hs 76918 Niemann-Pick di PatchedJM.SS 30
422746 NM.004484 Hs 119651 glypican 3 GlypicanJM.SS 30
453775 NM 002916 Hs 35120 replicadon fx AAAJM.SS 30
428862 NM.000346 Hs 2316 SRY (sex-determ HMG_box,TM, 29
401747 filamentJM, 29
429682 NM.006306 Hs 211602 SMC1 (strudura SMC CSMC.NJM, 29
413385 M34455 Hs 840 doleamine-pyr IDOJM, 29
442961 BE614474 Hs 289074 Homo sapiens cD TM 29
421650 AA781795 Hs 122587 ESTs TM 29
434398 AA121098 Hs 3838 serum-mducible pkinase.POLO.box.TM, 29
435706 W31254 Hs 7045 GL004 protein PDEaseJM, 29
416065 BE267931 Hs 78996 proliferating c TM 29
423493 AI815965 Hs 129683 ubiquitm-conju UQ con„SS 28
430242 U66669 Hs 236642 3-hydroxyιsobut TM 28
411770 NM.014278 Hs 71992 heat shxk prot HSP70JM, 28
400440 X83957 Hs 83870 nebulm TM 28
444743 AA045648 Hs 11817 nudix (nucleosi mutTJM, 28
417771 AA804698 Hs 82547 retinoic xid r TM 28
430287 AW182459 Hs 125759 ESTs. Weakly si TM.SS 28
408482 NM 000676 Hs 45743 adenosine A2b r 7tm 1,TM,SS 28
425188 AK002052 Hs 155071 hypothetical pr TM 28
456999 AA319798 Hs 172247 eukaryodc tran SS 28
408875 NM.015434 Hs 48604 DKFZP434B168 pr TM 28
409012 AL117435 Hs 49725 DKFZP434l216 pr RhoGEFJM, 27
410762 AF226053 Hs 66170 HSKM-B protein zf-MYND„SS 27
426925 NM 001196 Hs 172894 BH3 interxdng TM 27
410116 AW630671 Hs 58636 squamous cell c TM.SS 27
428398 AI249368 Hs 98558 ESTs SS 27
412140 AA219691 Hs 73625 RAB6 iπterxtin kinesmJM.SS 27
456655 AI376736 Hs 111779 sxreted protei kazal„SS 27
408670 AF160967 Hs 46784 potassium large TM.SS 27
422576 BE548555 Hs 118554 CGI-83 protein Ixtamase B„SS 27
431379 AA504264 Hs 182937 peptidylprolyl TM 27
433183 AF231338 Hs 222024 transcnpdon f HLH.PASJM.SS 27
432328 AI572739 Hs 195471 6-phosphofructo PGAM.6PF2KJM, 27
407633 NM 007069 Hs 37189 similar to rat TM.SS 26
419216 AU076718 Hs 164021 small inducible IL8JM.SS 26
422363 T55979 Hs 115474 replication fx TM 26
401644 zf-C2H2,TM, 26
417479 AI057052 Hs 133554 ESTs CARD.TM, 26 426514 BE616633 Hs 301122 bone morphogene TGF-beta TGFb_propepdde,TM,SS 26
400289 X07820 Hs 2258 matπx metallop hemopexιn„SS 26
418478 U38945 Hs 1174 cyclm-dependen ank,TM,SS 26
421246 AW582962 Hs 300961 ESTs, Highly si PolyA _pol,TM, 26
428048 AA705745 Hs 185070 ESTs AMP-bindmgJM, 26
452092 BE245374 Hs 27842 hypothedcal pr AcyltransferaseJM.SS 26
440052 AI633744 Hs 195648 ESTs PACJM.SS 26
452401 NM 007115 Hs 29352 tumor nxrosis Xlιnk,CUB,TM,SS 26
451813 NM 016117 Hs 27182 phosphdipase A WD40..SS 26
410889 X91662 Hs 66744 twist (Drosophi HLHJM. 26
422063 BE156476 gb QV0-HT0368-0 SS 26
418250 U29926 Hs 83918 adenosine onop A deammaseJM, 26
437641 AA811452 Hs 291911 ESTs TM 26
452571 W31518 Hs 34665 ESTs TM 26
411984 NM 005419 Hs 72988 signal fransduc SH2,STAT„SS 26
426427 M86699 Hs 169840 TTK protein kin pkinase.TM, 26
445848 AA774824 Hs 13377 Homo sapiens cf TM 26
420022 AA256253 Hs 120817 ESTs SS 26
451418 BE387790 Hs 26369 hypothedcal pr TM 26
428953 AA306610 Hs 194676 DKFZP434C013 pr arf,TNFR_c6,DEAD,Stathmιn,TM,SS 26
424008 R02740 Hs 137555 putadve chemok 7tm_1,TM, 26
417863 AB000450 Hs 82771 vxcmia relate pkinase.TM.SS 26
436961 AW375974 Hs 156704 ESTs TM 25
413670 AB000115 Hs 75470 hypothedcal pr TM 25
421928 AF013758 Hs 109643 polyadenylate b SS 25
439963 AW247529 Hs 6793 platelet-xtiva PAF-AH,HMG.box,pkιnase,TM, 25
426711 AA383471 Hs 180669 conserved gene TM 25
422631 BE218919 Hs 118793 hypothedcal pr TM 25
417866 AW067903 Hs 82772 collagen, type TSPN,Collagen,COLFI„SS 25
416975 NM.004131 Hs 1051 granzyme B (gra trγpsιn„SS 25
415947 U04045 Hs 78934 mutS (E cod) MutS_C,MutS_N,TM, 25
454678 AW813089 gb RC3-ST0186-2 TPR Ribosomal S5JM.SS 25
426572 AB037783 Hs 170623 hypothedcal pr PH.FYVE.TM, 25
428264 AA424839 Hs 98484 ESTs, Weakly si TM 25
444478 W07318 Hs 240 M-phase phospho kinesin,, SS 25
442295 AI827248 Hs 224398 Homo sapiens cD Collagen,COLFI,vwc,TM,SS 25
410094 BE147897 Hs 58593 general traπscr TFIIF betaJM, 24
413998 AW103807 Hs 243933 ESTs TPRTM.SS 24
412281 AI810054 Hs 14119 ESTs Ribosomal S7e,TM, 24
446852 AW451643 Hs 257479 ESTs, Weakly si TM 24
408915 NM 016651 Hs 48950 heptacellular c TM.SS 24
442991 BE281238 Hs 8886 hypothedcal pr TM 24
410193 AJ132592 Hs 59757 zinc finger pro zf-C2H2,TM, 24
410664 NM_006033 Hs 65370 lipase, eπdolhe Rιbosomal_L22,lιpase PLATJM.SS 24
423453 AW450737 Hs 128791 CGI-09 protein Granιn,CDP-OH_P_traπsf,TM, 24
411598 BE336654 Hs 70937 H3 histone fami hιstone„SS 24
429663 M68874 Hs 211587 phospholipase A C2.PLA2 B,TM, 24
428242 H55709 Hs 2250 leukemia mhibi LIF OSM„SS 24
419559 Y07828 Hs 91096 πng finger pro zf-C3HC4,zf-B boxJM, 24
419839 U24577 Hs 93304 phospholipase A SS 24
402819 IBRJM, 24
431457 NM 012211 Hs 256297 integnn, alpha FG-GAP,vwa,TM,SS 24
443683 BE241717 Hs 9676 uncharxtenzed DUF157JM, 24
422158 L10343 Hs 112341 protease mhibi wap„SS 24
423217 NM.0O0094 Hs 1640 collagen, type fn3,Collagen,Kunιtz BPTI,vwa„SS 24
408321 AW405882 Hs 44205 cortistadn TM 24
419086 NM 000216 Hs 89591 Kallmann syndro fn3 wap„SS 24
427722 AK0O0123 Hs 180479 hypothedcal pr PH„SS 24
405454 TM 24
422168 AA586894 Hs 112408 S100calcιum-bι efhand.TM, 23
421462 AF016495 Hs 104624 aquapoπn 9 MIPJM 23
403416 AI744626 Hs 301506 ESTs, Highly si SS 23
448988 Y09763 Hs 22785 gamma-ammobuty neur_chan,TM,SS 23
423198 M81933 Hs 1634 cell division c Rhodanese„SS 23
419926 AW900992 Hs 93796 DKFZP586D2223 p SS 23
429992 AL050053 Hs 227397 Homo sapiens mR fn3,TM SS 23
446232 AI281848 Hs 165547 ESTs 7tm.3,TM 23
422493 AW474183 Hs 233816 ESTs TM 23
407047 X65965 gb H sapiens SO sodfeJM, 23
411096 U80034 Hs 68583 mitxhondπal i Peptιdase_M3„ 23
426457 AW894667 Hs 169965 chimeπn (chima DAG.PE-bind.RhoGAPJM, 23
446545 AI431798 Hs 164192 ESTs, Weakly si TM 23
422094 AF129535 Hs 272027 F-box only prot TM 23
421933 R98881 Hs 109655 sex comb on mid SAMJM, 23
430001 AI580056 Hs 98992 ESTs TM 23
420802 U22376 Hs 1334 v-myb avian mye TM 23
402053 gpdh SS 23
432743 AH 46966 Hs 101656 ESTs SS 23
433409 AI278802 Hs 25661 ESTs PWWP,PHD,bromodoman,TM, 23
408330 AW182602 Hs 249954 ESTs TM.SS 23
407807 AL031427 Hs 40094 Human DNA seque T4_deιodιnase,TM 23
436972 AA284679 Hs 25640 claudin 3 PMP22 Claudιn,TM,SS 23
433730 AK002135 Hs 3542 hypothedcal pr TM SS 23 414839 X63692 Hs 77462 DNA (cytosιne-5 zf-CXXC BAH TM.SS 23
438192 AI859065 Hs 16808 ESTs, Weakly si TM SS 23
415339 NM.015156 Hs 78398 KIAA0071 protei ELM2JM 23
449539 W80363 Hs 58446 ESTs pkmase.Fuπn like.Rxep.L.domainJM.SS 22
450956 AW193531 Hs 205647 ESTs, Moderatel pkiπase.TM.SS 22
430335 D80007 Hs 239499 KIAA0185 protei SUM 22
417849 AW291587 Hs 82733 nidogen 2 EGF.Idl recept b thyroglobulin 1JM.SS 22
412326 R07566 Hs 73817 small inducible IL8..SS 22
408349 BE546947 Hs 44276 homeo box C10 homeoboxJM, 22
424704 AI263293 Hs 152096 cytxhrome P450 p450„SS 22
409632 W74001 Hs 55279 senne (or cyst serpm.TM, 22
415323 BE269352 Hs 949 neutrophil cyto SH3.TPR.TM 22
417531 NM.003157 Hs 1087 seπne/threonm pkinase.TM, 22
403137 rrm.TM.SS 22
428479 Y00272 Hs 184572 cell division c pkinase TM.SS 22
430200 BE613337 Hs 234896 gemimn TM.SS 22
425390 AI092634 Hs 156114 protein tyrosiπ ιg,Opιods_neuropep,TM,SS 22
408380 AF123050 Hs 44532 diubiquitm ubιquιbn,7tm_3,ANF_receptor,sushι,7tm_1,TM, 22
422424 AI186431 Hs 116577 prostate differ TGF-beta ,SS 22
400298 AA032279 Hs 61635 six transmembra TM 22
411571 AA122393 Hs 70811 hypothedcal pr SS 22
412802 U41518 Hs 74602 aquaponn 1 (ch MIPJM, 22
414761 AU077228 Hs 77256 enhancer of zes SETJM, 22
408432 AW195262 gb n67b05 x1 N TM.SS 22
429568 AI088691 Hs 208414 Homo sapiens mR mito carrJM, 22
425300 AW601773 Hs 270259 ESTs TM 22
439653 AW021103 Hs 6631 hypothedcal pr TM.SS 22
426827 AW067805 Hs 172665 methylenetetrah THF DHG.CYH.FTHFSJM, 22
444514 AI682905 Hs 270431 ESTs, Weakly si cNMP bιndιng,TM,SS 22
425322 U63630 Hs 155637 protein kinase, MCMJM. 22
421662 NM 014141 Hs 106552 cell recognido lammin.G TM.SS 22
438788 AA825716 gb od29e10 s1 N aπk,death,RHD,TM, 22
429058 AF138863 Hs 194827 hypothetical pr TM 22
423104 AJ005273 Hs 123647 antigenic deter TM 22
410406 AI969703 Hs 301842 ESTs FGGYJM, 22
421379 Y15221 Hs 103982 small inducible IL8.TM SS 22
422809 AK001379 Hs 121028 hypothetical pr IQJM 22
418049 AA211467 Hs 190488 hypothedcal pr TM 22
436209 AW850417 Hs 254020 ESTs, Moderatel TM.SS 22
408042 AL049233 Hs 42244 Homo sapiens mR TM 22
425692 D90041 Hs 155956 N-xetyltransfe Acetyltransf2,TM, 22
409665 NM 006731 Hs 55777 Fukuyama type c SS 22
428157 AI738719 Hs 298668 ESTs hexokinase.TM, 22
410480 R97457 Hs 63984 cadhenn 13, H- cadheπn.TM.SS 22
429732 U20158 Hs 2488 lymphxyte cyto SH2.TM, 22
414747 U30872 Hs 77204 centromere prot SS 22
425843 BE313280 Hs 159627 death assxiate TM 22
445299 AI910382 Hs 118727 Homo sapiens cD HLHJM 21
436251 BE515065 Hs 5092 nudeolar prote Nop TM.SS 2 1
430066 AI929659 Hs 237825 signal recognit TPR ,SS 21
427528 AU077143 Hs 179565 minichromosome MCMJM SS 2 1
448089 AI467945 Hs 173696 ESTs TM SS 2 1
428728 NM_016625 Hs 191381 hypothetical pr TM 21
409929 R38772 Hs 172619 KIAA1106 protei TM 2 1
405264 SS 21
445625 BE246743 Hs 288529 Homo sapiens cD TM 2 1
408949 AF189011 Hs 49163 putadve nbonu Rιbonuclease_3,TM,SS 2 1
424513 BE385864 Hs 149894 mitochondrial t GTP EFTU.IF2JM, 21
433683 AI817723 Hs 22678 hypothetical pr SS 21
442952 AI743261 Hs 131860 ESTs TM 2 1
432378 AI493046 Hs 146133 ESTs TM 21
417979 AU077284 Hs 83081 GTP cyclohydrol TM SS 2 1
433849 BE465884 Hs 280728 ESTs SS 21
437928 NM_005476 Hs 5920 UDP-N-xetylglu ROK,Epιmerase_2 TM, 21
403055 filamentJM.SS 2 1
432840 AK001403 Hs 279521 hypothetical pr TM 21
418994 AA296520 Hs 89546 selxdn E (end EGF,lxtιn_c,sushι,TM,SS 2 1
440908 AI915225 Hs 126735 ESTs TM 21
417621 AV654694 Hs 82316 interferon-mdu TM 2 1
436895 AF037335 Hs 5338 carbonic anhydr cartj anhydrase.TM.SS 21
408420 NM.006915 Hs 299481 Homo sapiens mR TM 2 1
434064 AL049045 Hs 180758 hypothedcal pr cadhenn.TM.SS 2 1
404076 RmaADJM, 21
422515 AW500470 Hs 117950 muldfuncdonal AIRC SAICAR.synt ,TM 2 1
445867 AF272663 Hs 13405 gephyπn MoCF.biosynthJM, 2 1
441021 AW578716 Hs 7644 H1 histone fami Imker iistoneJM, 2 1
446595 T57448 Hs 15467 hypothetical pr TM SS 2 1
417515 L24203 Hs 82237 ataxia-telangie zf-B box„SS 2 1
412429 AV650262 Hs 75765 GR02 oncogene IL8JM.SS 2 1
449207 AL044222 Hs 23255 nucleopoπn 155 TM.SS 2 1
412095 AI624707 Hs 5921 Homo sapiens cD TM.SS 2 1
400861 pkinase.TM, 2 1
440591 AA431599 Hs 132799 Homo sapiens cO TM 21 442104 1-20971 Hs 188 phosphodiestera PDEaseJM, 2 1
446921 AB012113 Hs 16530 small inducible IL8„SS 2 1
446051 BE048061 Hs 153315 ESTs Reprolysιn,Pep_M12B_propep,TM SS 2 1
422675 BE018517 Hs 119140 eukaryodc tran elF-5a ,TM 2 1
425170 AU077315 Hs 154970 transcπption f TM 2 1
453751 R36762 Hs 101282 Homo sapiens mR TM 21
426283 NM 003937 Hs 169139 kynureninase (L TM 2 1
417874 BE616160 Hs 82829 protein tyrosin Y_phosphatase,TM, 2 1
449555 AW450288 Hs 195390 ESTs TM 2 1
439699 AF086534 Hs 187561 ESTs, Moderatel TM 2 1
427413 BE547647 Hs 177781 superoxide dism sodfe.TM, 21
407802 D84145 Hs 39913 novel RGD-conta hexapepJM.SS 20
446035 NM 006558 Hs 13565 Sam68-lιke phos TM 20
406981 S71129 Hs 296844 Acetylcholinest COesterase.TM.SS 20
432343 NM.002960 Hs 2961 S100 calciuπvbi S_100,efhand,TM SS 20
414890 BE281095 Hs 77573 undine phospho PNP UDP_1,TM,SS 20
423019 AI640185 Hs 225816 ESTs SS 20
422278 AF072873 Hs 114218 frizzled (Droso Fz,Fnzzled,TM,SS 20
405545 ABC Iran BC membraneJM.SS 20
446237 AW270515 Hs 149596 ESTs bZIP.TM, 20
428074 BE387770 Hs 182378 colony stimulat SS 20
423430 AF112481 Hs 128501 RAD54, S cerev SNF2_N,helιcase_C,TM, 20
435767 H73505 Hs 117874 ESTs Peptdase_S8,P,TM, 20
432945 AL043683 Hs 271357 ESTs, Weakly si PK„SS 20
404170 sodfe.TM, 20
422610 AF153820 Hs 1547 potassium iπwar IRKJM, 20
417933 X02308 Hs 82962 thymidylate syn thymιdylat_synt SS 20
441384 AA447849 Hs 288660 protease, seπn TM 20
414020 NM.002984 Hs 75703 small inducible IL8..SS 20
427674 NM 003528 Hs 2178 H28 histone fam histoneJM.SS 20
435425 H16263 Hs 31416 ESTs TM 20
429782 NM 005754 Hs 220689 Ras-GTPase-xd rrm,NTF2„SS 20
417366 BE185289 Hs 1076 small proline r Cornifin.TM, 20
426746 J03626 Hs 2057 undine monopho Pnbosyltraπ.OMPdxaseJM, 20
432677 NM 004482 Hs 278611 UDP-N-xetyl-al Glycos_transf_2,Ricm_B_lxdnJM, 20
TABLE 43B
Pkey Uniq ue Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank xcession numbers
Pkey CAT number Axession
408432 1058667.1 AW195262 R27868 AW811262
411560 1249443 1 AW851186 AW996967 BE143456
422063 210852 ϊ BE156476 BE156473 BE156474 BE156475 AA302839
422285 214669 1 AI803103 AI885143 AW470793 AW450703 AI090784 AW271587 AW236950 AW242783
422689 219896 1 AW856665 AA315006 AW954733
423871 232749 1 AA331906 AA332484
438788 465159.1 AA825716 AW978859 AA828841
454456 1207088 1 AW850984 AW752836 M86124
454678 1228915 1 AW813089W28102
TABLE 43C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publication endtled 'The DNA . human chromosome 22* Dunham et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted
NLposition Indicates nucleotide positions of predicted exons
Pkey Ref Strand NLposition
400861 9757506 Plus 163855164016
401644 8576138 Plus 8265583959
401747 9789672 Minus 118596-118816,119119-119244,119609-119761,120422-120990 130161-130381 130468-130593,131097-131258.131866-
131932,132451-132575.133580-134011
402053 8083229 Plus 62703-63179
402819 6729581 Plus 29217-29422
403055 8748904 Minus 109532-110225
403137 9211494 Minus 92349-92572,92958-93084,93579-9371293949-9407294591-94748,95214-95337
403776 7770611 Minus 1414-1513,1624-1756
404076 9931752 Minus 3848-3967
404170 9930793 Plus 168836-169248
405264 7329374 Plus 2855628684
405454 7656675 Plus 133807-134053
405545 1054740 Plus 118677-118807,119091-119296,121626121823
406434 9256651 Minus 17803-17931
TABLE 44A ABOUT 314 GENES DOWN-REGULATED IN STOMACH CANCER
Table 44A lists about 314 genes significandy down-regulated in stomxh cancer compared to normal stomxh These were selxted as for Table 42A, except that the numerator and denominator were switched
Pkey Unique Eos probeset identifier number
ExAccn Exemplar Axession number, Genbank accession number
UnigenelD Unigene number Unigene Title Unigs me gene dtle
R1 Rado of tumor to normal dssue
Pkey ExAxn UnigenelD Unigene Title R1
412859 NM 000705 Hs 813 ATPase, H+/K+ exchanging, beta polypepd 001
415447 Z97171 Hs 78454 y∞iliπ, trabxular meshwork inducible 005
427469 AA403084 Hs 269347 ESTs 005
407486 S69741 gb hSCG-3=stomxh cancer gene-3 (oncogen 006
428602 AL137479 Hs 186655 Homo sapiens mRNA, cDNA DKFZp434M0223 (f 006
402761 8E387621 Hs 108809 chaperonin contaπing TCP1, subunit 7 (e 007
443547 AW271273 Hs 23767 Homo sapiens cDNA FLJ12666 fis, clone NT 007
430130 AL137311 Hs 234074 Homo sapiens mRNA, cDNA DKFZp761G02121 ( 007
435473 N53550 Hs 260881 ESTs 007
455826 BE144228 gb MRO-HT0165-140200-009-d04 HT0165 Homo 007
402015 008
430664 AW969834 gb EST381912 MAGE resequences, MAGK Homo 009
444515 AW204908 Hs 169979 ESTs 009
429201 X03178 Hs 198246 group-spxific component (vitamin D bind 010
434424 AI811202 Hs 125365 Homo sapiens cDNA FU23523 fis, clone L 010
450940 ' AI744943 Hs 300744 ESTs, Moderately simila to ALU7_HUMAN A 010
400811 AF219139 Hs 87726 KIAA0154 protein, ADP-nbosylation fxto 0 10
424596 AB020639 Hs 151017 estrogen-related rxeptor gamma 011
403670 011
410234 NM 003837 Hs 61255 fπιctose-1,6-bιsphosphatase 2 012
407462 AJ 252011 gb Homo sapiens partial mRNA for amiloπ 013
405110 0 13
402760 013
408947 AL080093 Hs 49117 Homo sapiens mRNA, cONA DKFZp564N1662 (f 013
413724 AA131466 Hs 23767 Homo sapiens cDNA FU 12666 fis, clone NT 0 14
431514 AW972363 gb EST384454 MAGE resequences, MAGL Homo 0 14
451103 R52804 Hs 25956 DKFZP564D206 protein 0 14
452033 AW273741 Hs 246977 ESTs 016
440058 AI932662 Hs 164073 ESTs 016
405645 0 17
429093 NM 000253 Hs 195799 microsomal tπglycende transfer protein 017
445627 AW818475 Hs 7363 ESTs 0 19
425679 X05997 Hs 159177 lipase, gastnc 019
417296 L36196 Hs 81884 sulfotransferase family, cytosolic 2A, 0 19
443537 D13305 Hs 203 cholxystokinin 8 rxeptor 020
435654 AW139612 Hs 131041 ESTs 020
406326 0 20
454120 AB032990 Hs 0719 hypothetical protein KIAA 1164 020
455541 AW993005 gb RC2-BN0032-160200-013-d04 BN0032 Homo 0 21
453989 M63962 Hs 36992 ATPase, H+/K+ exchanging, alpha polypept 023
407261 L03172 gb Homo sapiens cell-type T-cell immunog 0 23
451062 AL110125 Hs 25910 Homo sapiens mRNA, cDNA DKFZp564C1416 (f 023
429350 AI754634 Hs 131987 ESTs 0 23
411021 F00055 Hs 172004 ddn 024
441212 AW242447 Hs 146182 ESTs, Weakly similar to Ixtase phloπzi 024
450572 AI700863 Hs 202494 Homo sapiens cDNA FU13245 fis, clone OV 0 25
444922 AI921750 Hs 144871 Homo sapiens cDNA FU13752 fis, clone PL 026
421562 AA530994 Hs 105803 ghrelm precursor 026
457432 NM 005136 Hs 268538 potassium voltage-gated channel, Isk-rel 0 26
418421 R58620 Hs 85050 phospholamban 026
424104 AA669515 Hs 144950 ESTs 026
422582 AA312660 gb EST183335 Jurtat T-cells VI Homo sapi 0 26
417332 AW972717 Hs 288462 Homo sapiens cDNA FU21511 fis, clone C 027
432440 X63597 Hs 2996 sucrase-isomaltase 027
448520 AB002367 Hs 21355 doublecortin and CaM kinase-like 1 0 28
401989 0 28
452528 AA742457 Hs 291479 ESTs 0 28
412569 H63789 Hs 296288 ESTs Weakly similar to KIAA0638 protein 028
434779 AF153815 Hs 50151 potassium inwardly-rectifying channel, s 0 28
406255 029
419293 AA746282 Hs 255659 ESTs 029
428649 AL045716 Hs 188228 Homo sapiens cDNA FLJ11003 fis, clone PL 029
410036 R57171 Hs 57975 calsequesfrm 2, cardix muxle 0 29
414502 AL133721 Hs 224680 ESTs 029
432113 AA935065 Hs 152385 ESTs 029
413808 J00287 Hs 182183 caldesmon 1 029
451406 AI694320 Hs 6295 ESTs, Weakly similar to T17248 hypothed 029
434745 AW974445 Hs 185155 ESTs, Weakly similar to HuEMAP [H sapien 030
420444 AI905985 Hs 111805 ESTs 0 30
445200 AA084460 Hs 12409 somatostatin 030
415314 N88802 HS 5422 glycoprotein M6B 030
427019 AA001732 Hs 1 3233 hypothedcal protem FU10970 030
431152 AW970998 gb EST383083 MAGE resequences, MAGK Homo 030
432306 Y18207 Hs 274315 protein phosphatase 1, regulatoiy ( hib 031
401775 031
440059 AW467335 Hs 257676 ESTs 0 31
436089 AA804957 Hs 119840 ESTs 031
447071 AW236867 Hs 244376 ESTs 032
435604 AA625279 Hs 26892 uncharxteπzed bone maπow protein BM04 032 423968 AF098277 Hs 136529 solute caπer family 23 (nucleobase tra 032
445487 AI806287 Hs 201217 ESTs 032
421296 NM 002666 Hs 103253 peπlipin 032
427138 N77624 Hs 173717 phosphaddic xid phosphatase type 2B 033
449916 T60525 Hs 299221 ESTs 033
446393 AW014174 Hs 151707 ESTs 033
446632 AI333565 Hs 159073 diacylglycerol kinase, eta 033
428070 T63918 Hs 182313 rednol-binding protein 2, cellula 033
421451 AA291377 Hs 50831 ESTs 033
405817 033
454790 AW820852 gb RC2-ST0301-120200-011-f12 ST0301 Homo 033
413679 BE156765 gb RC1-HT0370-120100-012-C09 HT0370 Homo 034
404121 034
433084 M18079 Hs 282265 fatty xid binding protein 2, intestinal 034
413079 BE064382 gb RC4-8T0310-110300-015<12 BT0310 Homo 034
403059 035
458987 AW750067 Hs 205386 ESTs 035
429609 AF002246 Hs 210863 cell adhesion molecule with homology to 035
423371 AU076819 Hs 1650 solute earner family 26, member 3 035
424765 AA428211 Hs 284256 hypothedcal protein FLJ 14033 simila to 035
451818 AI819018 gb ts54f01 x1 NCI_CGAP_Kιd8 Homo sapiens 035
438380 T06430 HS 6194 chondroidn sulfate proteoglycan BEHAB/b 035
405742 035
403429 035
443622 AI911527 Hs 11805 ESTs 036
404973 036
444567 AV654020 Hs 184261 ESTs, Weakly similar to putadve type II 036
412228 AW503785 Hs 73792 complement component (3d/Epsteιn Barr vi 036
407110 AA018042 Hs 95078 ESTs 036
411671 BE049094 Hs 278567 ESTs 036
430800 NM 000805 Hs 2681 gastπn 036
454560 AW807281 gb MR4-ST0062-240300-003-g01 ST0062 Homo 036
444536 AI161068 Hs 14780 ESTs 036
454042 H22570 Hs 172572 hypothedcal protein FU20093 0 37
444102 AV647953 Hs 282379 ESTs 037
424122 AA335593 Hs 116147 ESTs 037
452093 AA447453 Hs 27860 Homo sapiens mRNA, cDNA DKFZp586M0723 (f 037
436277 R88520 Hs 120917 ESTs 037
456350 BE246762 Hs 89499 arxhidonate 5-lιpoxygenase 037
451027 AW519204 Hs 40808 ESTs 037
426784 U03749 Hs 172216 chromogranm A (parathyroid sxretory pr 038
410023 AB017169 Hs 57929 slit (Drosophila) homolog 3 038
436802 N34486 Hs 170504 ESTs 038
448142 AI521768 Hs 164586 ESTs 038
442378 R54033 Hs 21245 ESTs 038
446406 AI553681 Hs 25248 ESTs 038
455753 BE075124 gb PM1-BT0585-110200-003-h028T0585 Homo 038
424903 T26477 Hs 22883 ESTs, Weakly similar to ALU8JHUMAN ALU S 038
406714 AI219304 Hs 283108 hemoglobin, gamma G 039
434340 Al 193043 Hs 128685 ESTs 039
406036 0 39
431078 U82827 Hs 249195 homeo box A13 039
-457663 AW371946 Hs 116119 ESTs 0 39
451880 AI821032 Hs 209387 ESTs 039
419219 AW583139 Hs 89717 carboxypepddase A2 (pancreatic) 0 39
446414 W93246 Hs 59187 ESTs 039
442317 AI915599 Hs 129225 ESTs 039
447261 NM 006691 Hs 17917 lymphadc vessel endothelial hyaluronan 039
439569 AW602166 Hs 222399 CEGP1 protein 039
433485 AI493076 Hs 78183 aldo-keto reductase family 1, member C1 040
432753 NM 014075 Hs 278915 PRO0593 protein 040
420200 AI271429 Hs 88142 ESTs 040
421863 AI952677 Hs 108972 Homo sapiens mRNA, cDNA DKFZp434P228 (fr 040
453950 AA156998 Hs 211568 eukaryodc transladon initiation fxtor 040
407408 AF054830 gb Homo sapiens ιnterieukιn-1 type I rx 040
410732 AW984328 gb PM3-HN0010-050400-001-h12 HN0010 Homo 040
458272 AI797360 Hs 264899 ESTs, Weakly simila to ALU3.HUMAN ALU S 040
401514 AF147186 gb AF147186 Homo sapiens library (Schere 040
436363 AA843926 Hs 124434 ESTs 040
434445 AI349306 Hs 11782 ESTs 040
413272 AA127923 Hs 293256 ESTs 040
409681 N51508 Hs 143718 ESTs 040
454554 AW847505 gb RCO-CT0210-280999-021-C10 CT0210 Homo 040
450891 AI743118 Hs 238914 ESTs, Weakly similar to neuregulm-4 sho 040
452078 AA022620 Hs 52170 ESTs 041
419278 AU076799 Hs 1247 apolipoprotein A-IV 041
433637 AW024214 Hs 135405 ESTs 041
449923 BE258051 gb 601111034F1 NIH_MGC_16 Homo sapiens c 041
416982 J05401 Hs 80691 creadne kinase, itxhondπal 2 (sar∞m 041
453139 AA330620 Hs 240559 ESTs 041
408614 AL137698 Hs 46531 Homo sapiens mRNA, cDNA DKFZp434C1915 (f 041
437931 AI249468 Hs 145274 ESTs 041
402759 041 450888 AW021446 Hs 80714 ESTs 041
417318 AW953937 Hs 12891 ESTs 041
407244 M10014 Hs 75431 fibπnogen gamma polypeptide 041
424884 AW299437 Hs 225717 ESTs 041
439024 R96696 Hs 35598 ESTs 042
423732 AF058056 Hs 132183 solute earner family 16 (monxarboxylic 042
409300 AA126190 gb zm78f03 r1 Stratagene neuroepithelium 042
444237 AA336878 Hs 9842 Human DNA sequence from clone RP4-788L20 042
425860 L29339 Hs 1964 solute earner family 5 (sodium/glucose 042
447021 AI356564 Hs 161406 ESTs 042
422270 AF114494 Hs 114062 protein tyrosine phosphatase-like (proli 042
407850 AW086230 Hs 244912 ESTs 042
449884 AI673110 Hs 222195 ESTs 042
436327 AA813075 Hs 120181 ESTs 042
415972 H11436 Hs 260201 ESTs 042
400917 043
435309 AW089050 Hs 187993 ESTs 043
424410 W79027 Hs 271762 ESTs 043
445577 N40696 Hs 146077 ESTs 043
411069 AL133092 Hs 68055 hypothedcal protein DKFZp434l0428 043
440286 U29589 Hs 7138 cholinergic receptor, muscaπnic 3 043
451123 AI927224 Hs 213480 ESTs 043
457151 AW206116 Hs 253538 ESTs 043
459185 AI908222 gb RC-BT165300399-020 BT165 Homo sapien 043
411607 AW853498 gb RC1-CT0252-170200-025h02 CT0252 Homo 043
424815 AA347287 Hs 104573 ESTs 043
429704 AA584440 Hs 185812 ESTs 043
411067 AI6810O6 Hs 301543 ESTs 043
430172 AA468591 Hs 161889 ESTs 043
435124 AA725362 Hs 120456 ESTs 043
445966 L17330 Hs 280 pre-T/NK cell assxiated protein 043
443741 AW451759 Hs 145420 ESTs 043
416275 H42823 Hs 155742 glyoxylate reductase/hydroxypyruvate red 044
451138 W92287 Hs 40268 ESTs 044
409038 T97490 Hs 50002 small inducible cytokine subfamily A (Cy 044
426730 AL040738 gb DKFZp434B1615 434 (synonym htes3) 044
410066 AL117664 Hs 58419 DKFZP586L2024 protein 044
427965 D00306 Hs 183864 elastase 3B 044
418026 BE379727 Hs 83213 fatty xid binding protein 4, adipxyte 044
408479 BE047329 Hs 144483 ESTs 044
457994 AW136239 Hs 132922 ESTs 044
435564 AF210652 Hs 16614 5(3)-deoxynbonuclxddase (dNT-2), nucl 045
435869 AF255910 Hs 54650 vascular endothelial junction-associated 045
434399 AA878845 Hs 125769 ESTs 045
415797 AI291896 Hs 72800 ESTs 045
430264 AA470519 gb nc7K10 s1 NCI CGAP PM Homo sapiens 045
409435 AI810721 Hs 95424 ESTs 045
433542 AA598869 Hs 173770 ESTs 045
455400 AW936342 gb QV4-DT0021-281299-070-h12 DT0021 Homo 045
412047 AA934589 Hs 49696 ESTs 045
443948 T56148 Hs 9997 Homo sapiens mRNA full length insert cDN 045
450307 AW450336 Hs 201783 ESTs 045
434500 AF143877 Hs 215047 Homo sapiens clone IMAGE 113431 mRNA seq 045
420460 AA262331 Hs 135503 ESTs 045
450752 AA012986 Hs 60466 ESTs 045
418138 AA213626 Hs 136204 EST 045
441088 AA916546 Hs 126546 ESTs 046
410990 AW812929 gb RC3-ST0186-250200-01&O05 ST0186 Homo 046
438211 T08401 gb EST06292 Infant Brain, Bento Soares H 046
434349 NM.015678 Hs 3821 neurobexhm 046
409824 AW501063 gb UI-HF-BPOp-az-c-01-O-UI r1 NIH.MGC.5 046
403279 046
434882 AW974752 Hs 269497 ESTs 046
404629 046
427393 AB029018 Hs 177635 KIAA1095 protein 046
454651 AW812091 gb RC4-ST0173-191099-032 .04 ST0173 Homo 046
401992 046
457275 AA463422 Hs 209431 ESTs 046
403710 046
419728 L36861 Hs 92858 guanylate cyclase xdvator 1A (retina) 046
401075 046
421387 AF059566 Hs 103983 solute earner family 5 (sodium iodide s 046
453404 AA035446 Hs 261224 ESTs 046
407208 T10695 Hs 102948 enigma (LIM domain protein) 046
440681 AW449696 Hs 166547 ESTs 046
454206 AW810279 gb MR4-ST0125151299-029-a09 ST0125 Homo 047
402466 047
429996 N90822 Hs 48969 ESTs 047
403680 047
428151 AA422028 gb zv26g06 r1 Soares_NhHMPu_S1 Homo sapi 047
410495 N95428 gb zb80d09 s1 Soares_senescent_fibroblas 047
402851 047
438421 AA806907 Hs 194451 ESTs 047 454661 BE244138 gb TCBAP1E1218 Pediatnc pre-B cell ut 047
408753 AI337192 Hs 47438 SH3 domain binding glutamic xid-πch pr 047
409106 AW337854 Hs 177386 ESTs 047
413199 M62843 Hs 75236 ELAV (embryonic lethal, abnormal vision, 047
442799 AI564739 Hs 68505 ESTs 047
457955 AI208986 Hs 143945 ESTs 047
458147 AW752597 gb IL3-CT0214-161299-045B06 CT0214 Homo 047
407938 AA905097 Hs 85050 phospholamban 047
414141 BE255083 gb 601111390F1 NIH MGC 16 Homo sapiens c 047
448869 AI792798 Hs 12496 ESTs 047
400749 047
458745 AW207347 Hs 211101 ESTs 048
418437 AA771738 Hs 295351 ESTs 048
452286 AI358570 Hs 123933 ESTs 048
430369 AA477631 Hs 119484 ESTs 048
453572 AA382590 Hs 31848 ESTs, Weakly similar to hypothedcal pro 048
455175 AW993247 gb RC2-BN0033-180200-014-h09 BN0033 Homo 048
445765 AV655102 Hs 117266 ESTs 048
400322 AF045576 Hs 247758 olfxtorγ receptor, family 5, subfamily 048
412526 M90366 Hs 73982 zona pelluαda glycoprotein 2 (sperm rx 048
407986 U32659 Hs 41724 interieukin 17 (cytotoxic T-lymphocyte-a 048
455479 AW948312 gb RCO-MT0015-280300-021-h04 MT0015 Homo 048
450308 AI692571 Hs 201681 ESTs 048
411149 N68715 Hs 269128 ESTs 048
453982 AW014252 Hs 252837 ESTs 048
410971 AW812258 gb RC0-ST0174-191099-031-M-2 ST0174 Homo 048
410839 NM_O06849 Hs 66581 protein disulfide isomerase 048
421553 AA536080 Hs 97302 ESTs 048
442376 W95588 Hs 129982 Homo sapiens cDNA FU 12228 fis, clone MA 048
454754 AW819191 gb CM1-ST0283Λ)71299-061-d08 ST0283 Homo 048
447858 AW080339 Hs 211911 ESTs 049
422639 AI929377 Hs 173724 creadne kinase, brain 049
402449 049
420440 NM_002407 Hs 97644 mammaglobin 2 049
435056 AW023337 Hs 5422 glycoprotein M6B 049
419543 AA244170 Hs 188719 ESTs 049
407033 U78628 gb Human leukemia inhibitory fxtor rxe 049
437468 AA457619 gb aa89d11 r1 Stratagene fetal redna 93 049
412639 AW961284 Hs 296235 ESTs 049
406109 049
404519 049
410285 AA083609 gb zm63d05 r1 Stratagene fibroblast (937 049
406014 049
400938 049
414290 AI568801 Hs 71721 ESTs 049
432433 AW014734 Hs 157969 ESTs 049
405273 049
454738 BE072139 gb PM1-BT0533-291299-002-b05 BT0533 Homo 049
414383 BE279406 gb 601157981F1 NIH.MGC.21 Homo sapiens c 049
445911 AI985987 Hs 145645 ESTs, Moderately similar to ALU1 HUMAN A 049
451241 AI767545 Hs 209572 ESTs 049
428336 AA503115 Hs 183752 microsemmoprotein, beta- 049
418310 AA814100 Hs 86693 ESTs 049
452152 AL046755 Hs 28219 protein phosphatase 2 (formerly 2A), reg 049
454869 AW836004 gb P 0-LT0019- 1 0200-001 -d 11 LT0019 Homo 049
400332 S66407 Hs 248032 FLT4 049
425280 U31519 Hs 1872 phosphoenolpyruvate carboxyk ase 1 (sol 049
408221 AA912183 Hs 7447 ESTs 049
440179 AI990151 Hs 125904 ESTs 050
425360 BE547704 gb 601076309F1 NIH.MGC.12 Homo sapiens c 050
406600 050
418594 AI732083 Hs 187619 ESTs 050
432128 AA127221 Hs 117037 ESTs 050
458611 AI268407 Hs 211458 ESTs 050
426495 NM 001151 Hs 2043 solute earner family 25 (mitxhondnal 050
441068 AA913897 Hs 233559 ESTs 050
428108 AA421452 Hs 164851 ESTs 050
400803 050
439996 AA916565 Hs 221675 ESTs 050
TABLE 44B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank xcession numbers
Pkey CAT number Accession
409300 111676 1 AA126190 AA074486 AA074707 AA070059 AA084886
409824 1155499J AW501063AW503034 AW501523
410285 119128 1 AA083609 AA083790 AA112048
410495 1205826 1 N95428 W24040AW751366 H81987
410732 1218556 1 AW984328 AW984322 AW984318 AW984330 R58427 AW984332 AW799807 A\ IV98432
410971 1228216 1 AW812258 AW812252 AW812261 AW812263 AW812285 AW812277 AW812264 I
410990 1228649 1 AW812929 AW812779 AW813088 411607 1251251 1 AW853498 AW853442 AW853590 AW853433 AW853592
413079 1348528 1 BE064382 BE064387 BE064385 BE064381 BE153367 BE153366 BE153401 BE153385 BE064372
413679 1382784.1 BE156765 BE156770 BE156767 BE156769 BE156803 BE156802 BE156847 BE156853 BE156780 BE156836 BE156792 BE156834 BE156779
BE156789 BE156833 BE156844 BE156831 BE156849 BE156797 BE156784 BE156801 BE156843 BE156793 BE156852
414141 1420715 1 BE255083 BE257634
414383 1440279 1 BE279406 BE280100
422582 218132 ϊ AA312660AI474863
425360 250631 1 BE547704 AA355909
426730 271055 1 AL040738 AA383683
428151 287658 1 AA422028 W79191
430264 315008 1 AA470519 BE303010 BE302954 BE384120
430664 321423 1 AW969834 AA528493 AA483165 AW969842
431152 328675 1 AW970998 AW971004 AA574217 AA493538
431514 334213 1 AW972363 AA506335 AI077445
437468 43743 1 AA457619 AL390167
438211 45225 1 T08401 Z83934T16897
449923 81926 1 BE258051 R45758 AA004732 BE255126
451818 887271 1 AI819018 R05492 W27615
454206 1050848 1 AW810279 BE146684 BE146693 BE146694 BE146679 AW810472 AW810208 AW810356 AW810193 AW178838 AW178837 AW178857 AW810515
AW810330 AW810514 AW810441 AW810358 AW178852 AW810359 AW810322 AW810327 AW810211 AW178835 AW810635 AW810288 AW810263
AW810325 AW810443 AW810198 AW810321 AW810265 AW810567 AW810447 AW810328 AW810513 BE146674 AW810257 AW810185 AW810281
AW810258 BE062400 AW810323 AW810293 BE146652 AW810516 BE146689 AW810289 AW810566 AW810636 AW178842 BE062434 BE146653
AW810536 AW846649
454554 1223842 1 AW847505 AW811792 BE061442 BE061433 AW847506 AW806999 AW806996 BE061436 BE061430 BE142460 BE146499 AW806994 AW809156
AW806991 AW814082 AW806992 BE061669 AW8070028E146659 AW806995 AW807000 AW845743 AW845747 AW847504 BE142458 BE061431
BE061435 AW847507 BE146650 BE142470 AW814096 AW807012 BE061438 AW807011 AW806993 BE142465 BE142459 BE142462 AW854330
AW854331 BE061434 BE061731 BE142464 AW847501 AW807001 BE142463AW811800 BE061437 AW811802 BE061440 AW806997 AW806998
BE061745 BE061753
454560 1223940.1 AW807281 AW807092 AW807425 AW807330 AW807174 AW807171 AW807274 AW807278 AW807367 454651 1228069.1 AW812091 AW812228 AW812106 AW938581 AW812080 454661 1228527.1 BE244138 BE244727 AW812636 AW812647 454738 1232449.1 BE072139 BE157977 BE157974 AW857974 AW817778 454754 1233580.1 AW819191 AW819252 AW819183 AW819175 AW819177 AW819186 AW819180 BE158470 AW819242 AW819269 AW819244 AW819190 AW819265
AW819268 AW819246 BE152602 AW819249 AW819251 AW819263 AW819194
454790 1234752.1 AW820852 AW820773 AW821088 454869 1238137.1 AW836004 AW836087 AW836163 AW836162 AW836085 AW836084 AW836079 AW836083 AW836082 AW836086 AW836088 AW836166 AW836164
AW836002 AW836078 AW836161 AW862135 AW836165 AW836003
455175 1257335.1 AW993247 AW861464 455400 1288135.1 AW936342 AW936366 455479 1293163.1 AW948312 AW948286 AW948289 AW948297 AW948279 AW948295 455541 1323705.1 AW993005 AW993285 AW993290 455753 1356070.1 BE075124 BE075229 BE075278 455826 1373392.1 BE144228 BE144291 458147 488021.1 AW752597 AW848781 AW849062 AW848490 AW752699 AW752604 AW752700 459185 922823.1 AI908222 AI908224 AI908217
TABLE 44C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham, et al * refers to the publicadon endded "The DNA sequence of human chromosome 22* Dunham et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposidon Indicates nudeodde posidons of predicted exons
Pkey Ref Strand Nt posidon
400749 7331445 Minus 9162-9293
400803 8567875 Minus 18267-19088
400917 7283186 Minus 173258-173631
400938 7652890 Minus 92074-92423
401075 3687273 Plus 81218-81395
401514 7622355 Plus 93224-93292,94913-95065,95163-95334
401775 9966311 Minus 110228-110340
401989 4309964 Minus 118611-118821
401992 4153858 Plus 31452-31649
402015 7417802 Minus 48791-49043,50038-50205,51530-5167254448-54565,55933-56073
402449 9796674 Plus 59867-60039,62588-62828,6346563623,64923-65108
402466 9796919 Plus 57659-57866,58839-58908
402759 9213869 Plus 134117-134281
402760 9213869 Plus 136829-136952,137336-137521
402851 9650753 Minus 63022-63136,63683-63783
403059 8954192 Minus 69553-69702
403279 8072597 Plus 162569-162768,163918-164168
403429 9719566 Minus 52789-52917
403670 7259739 Minus 88377-88537
403680 7331517 Minus 157184-157415
403710 6437516 Plus 27413-28978
404121 9796219 Plus 59256-59401
404519 8152000 Plus 12817-13000
404629 9796665 Plus 55584-55796
404973 3213020 Plus 101602-102591
405110 8096888 Minus 118940-119100
405273 4156137 Minus 98141-98754
405645 4926864 Minus 92231-92380,92724-92869
405742 7283744 Minus 54424-55488 405817 4071056 Plus 19914-20112,2565525810
406014 6758904 Minus 23738-24076
406036 6758919 Plus 17942-18163
406109 9127147 Minus 58328-58485
406255 7417729 Plus 2959-3200
406326 9212385 Plus 84508-84655
406600 8248616 Minus 36296-36610
TABLE 45A ABOUT 947 GENES UP-REGULATED IN STOMACH CANCER COMPARED TO NORMAL ADULT TISSUES
Table 45A lists about 947 genes up-regulated in stomxh cancer compared to normal adult dssues These were selxted from 59680 probesets on the Affymetnx/Eos Hu03 GeneChip array such that the rado of "average* stomxh cancer to "average" nomial adult dssues was greater than or equal to 25 The "average" stomxh cancer level was set to the 90th percendle amongst vaπous stomxh cancers The "average" normal adult dssue level was set to the 90th percendle amongst vaπous non-malignant dssues In order to remove gene-spxific bxkground levels of non-spxific hybndizadon, the 15th percendle value amongst vaπous non-malignant dssues was subtrxted from both the numerator and the denominator before the rado was evaluated
Pkey Unique Eos probese it idendfier number
ExAxn Exemplar Axession number, Genbank accession number
UnigenelD Unigene number
Unigene Tide Unigene gene dde
R1 Rado of stomxh caicer compared to normal stomxh
Pkey ExAxn UnigenelD Unigene Tide R1
418007 M13509 Hs 83169 matπx metalloproteinase 1 (iπtersddal 6680
411243 AB039886 Hs 69319 CA11 61 16
428368 BE440042 Hs 83326 matπx metalloproteinase 3 (stromelysin 4236
427585 D31152 Hs 179729 collagen, type X, alpha 1 (Schmid metaph 3580
425679 X05997 Hs 159177 lipase, gastric 28 34
409041 AB033025 Hs 50081 KIAA1199 protein 2691
452121 NM.004081 Hs 70936 deleted in azoospermia 2622
403776 NA 2500
444783 AK001468 Hs 62180 anillin (Drosophila Scraps homolog), xt 2390
422956 BE545072 Hs 122579 hypothedcal protein FU 10461 2390
409187 AF154830 Hs 50966 carbamoyl-phosphate synthetase 1, mitxh 2335
424252 AK000520 Hs 143811 hypothedcal protein FU20513 2226
439759 AL359055 Hs 67709 Homo sapiens mRNA full length insert cDN 21 06
415989 AI267700 Hs 317584 ESTs 2072
416209 AA236776 Hs 79078 MAD2 (mitodc aπest deficient, yeast, h 1984
452401 NM 007115 Hs 29352 tumor nxrosis fxtor, alpha-induced pro 1550
438639 AI278360 Hs 31409 ESTs 15 16
426427 M86699 Hs 169840 TTK protein kinase 1454
449032 AA045573 Hs 22900 nuclear fxtor (erythroid denved 2)-lιk 1426
443211 AI128388 Hs 143655 ESTs 14 22
421470 R27496 Hs 1378 annexin A3 1396
400792 AA635062 Hs 50094 Homo sapiens mRNA, cDNA DKFZp434O0515 (f 1394
424086 AI351010 Hs 102267 lysyl oxidase 1373
437789 AI581344 Hs 127812 ESTs, Weakly similar to T17330 hypothed 1338
409757 NM_001898 Hs 123114 cystadn SN 1333
447033 AI357412 Hs 157601 ESTs 1320
447164 AF026941 Hs 17518 Homo sapiens cιg5 mRNA, partial sequence 1280
420159 AI572490 Hs 99785 Homo sapiens cDNA FU21245 fis, clone C 1266
432596 AJ224741 Hs 278461 matolin 3 1264
424905 NM 002497 Hs 153704 NIMA (never in mitosis gene a)-related k 1246
413582 AW295647 Hs 71331 hypothetical protein MGC5350 1232
423020 AA383092 Hs 1608 replication protein A3 (14kD) 1218
448693 AW004854 Hs 228320 hypothetical protein FU23537 11 74
442660 AW138174 Hs 130651 ESTs 11 73
441693 AA384673 Hs 7943 RPB5medιatιng protein 11 16
450221 AA328102 Hs 24641 cytoskeleton assxiated protein 2 11 08
414142 AW368397 Hs 150042 Homo sapiens cDNA FU 14438 fis, clone HE 1090
424717 H03754 Hs 152213 wingless-type MMTV integration site fami 1048
443715 AI583187 Hs 9700 cyclm E1 1044
420900. AL045633 Hs 44269 ESTs 1038
453922 AF053306 Hs 36708 budding uninhibited by benzimidazoles 1 1036
415076 NM 000857 Hs 77890 guanylate cyclase 1 , soluble, beta 3 1020
452291 AF015592 Hs 28853 CDC7 (cell division cycle 7, S cerevisi 10 18
410566 AA373210 Hs 43047 Homo sapiens cDNA FU13585 fis, clone PL 1014
414422 AA147224 Hs 337232 ESTs 10 12
409269 AA576953 Hs 22972 hypothedcal protein FU 13352 1002
414972 BE263782 Hs 77695 KIAA0008 gene product 1002
418882 NM 004996 Hs 89433 ATP-bindmg cassette, sub-family C (CFTR 980
428365 AA295331 Hs 183861 Homo sapiens cDNA FLJ20042 fis clone CO 972
416661 AA634543 Hs 79440 IGF-II mRNA-bmdmg protein 3 968
400195 NA NA 966
418738 AW388633 Hs 6682 solute earner family 7, (cationic ammo 964
420170 U43374 Hs 95631 Human noπnal keradπxyte mRNA 960
414259 W44633 Hs 301296 Homo sapiens cDNA FU23131 fis. clone L 958
417517 AF0O1176 Hs 82238 POP4 (prxessing of precursor S cerev 934
446998 N99013 Hs 16762 Homo sapiens mRNA, cDNA DKFZp564B2062 (f 926
429486 AF155827 Hs 203963 hypothetical protein FLJ 10339 9 16
428227 AA321649 Hs 2248 small inducible cytokine subfamily B (Cy 895
431810 X67155 Hs 270845 kinesin like 5 (mitodc kinesm-like pro 884
419261 X07876 Hs 89791 wingless type MMTV integration site fami 880
425921 NM_0O7231 Hs 162211 solute earner family 6 (neurotransmitte 878 424834 AK001432 Hs 153408 Homo sapiens cDNA FU10570 fis clone NT 869
413268 AL039079 Hs 75256 regulator of G-protem signalling 1 868
417801 AA417383 Hs 82582 integnn, beta-like 1 (with EGF-like rep 868
452461 N78223 Hs 108106 transcnpdon fxtor 868
425916 NM 006786 Hs 162200 urotensin 2 864
422805 AA436989 Hs 121017 H2A histone family, member A 854
438394 BE379623 Hs 27693 pepddylprolyl isomerase (cyclophιlιn)-l 852
441377 BE218239 Hs 202656 ESTs 841
445891 AW391342 Hs 199460 ESTs 831
408771 AW732573 Hs 47584 potassium voltage-gated channel, delayed 830
439521 AI808955 Hs 58248 ESTs 830
425087 R62424 Hs 126059 ESTs 828
424653 AW977534 Hs 151469 calcium/calmodulin-dependent senne prot 822
441795 N58115 Hs 21137 AD024 protein 802
427878 C05766 Hs 181022 CGI-07 protein 800
413583 AL120806 Hs 5888 ESTs 798
407853 AA336797 Hs 40499 dickkopf (Xenopus laevis) homolog 1 798
426269 H15302 Hs 168950 Homo sapiens mRNA cDNA DKFZp566A1046 (f 797
404996 NA 796
400289 X07820 Hs 2258 matrix metalloproteinase 10 (stromelysin 796
410044 BE566742 Hs 58169 highly expressed in cancer, πch in leuc 794
417655 AA780791 Hs 14014 hypothedcal protein FU14813 792
452838 U65011 Hs 30743 preferendally expressed andgen in mela 791
418895 AA894638 Hs 14600 ESTs 790
446155 AI553695 Hs 159422 Homo sapiens cDNA FU13997 fis, clone Y7 786
423123 NM 012247 Hs 124027 SELENOPHOSPHATE SYNTHETASE , Human selen 782
434539 AW748078 Hs 214410 ESTs, Weakly simila to MUC2_HUMAN MUCIN 780
447505 AL049266 Hs 18724 Homo sapiens mRNA, cDNA DKFZp564F093 (fr 772
418763 AK0OO219 Hs 88367 hypothetical protein FU20212 770
447289 AW247017 Hs 36978 melanoma antigen, family A, 3 770
443354 AW970672 Hs 9247 protein kinase, AMP-xdvated, alpha 1 c 769
427718 AI798680 Hs 25933 ESTs 766
434032 AW009951 Hs 206892 ESTs 760
427738 NM 000318 Hs 180612 peroxisomal membrane protein 3 (35kD, Ze 758
450480 X82125 Hs 25040 zinc finger protein 239 751
418678 NM.001327 Hs 167379 cancer/tesds andgen 749
431494 AA991355 Hs 298312 hypothetical protein DKFZp434A1315 744
452705 H49805 Hs 246005 ESTs 736
443646 AI085198 Hs 164226 ESTs 732
425420 BE536911 Hs 234545 hypothetical protein NUF2R 730
420617 AK001652 Hs 99423 ATP-dependent RNA helicase 728
421155 H87879 Hs 102267 lysyl oxidase 724
450715 AI266484 Hs 31570 ESTs Weakly similar to KIAA1324 protein 7 24
447254 NM 004153 Hs 17908 origin rxognidoπ complex, subunit 1 (y 722
435473 N53550 Hs 260881 ESTs 7 20
413293 AL047483 Hs 302498 GTP-binding protein homologous to Sa∞ha 714
449347 AV649748 Hs 295901 KIAA0493 protein 7 11
452281 T93500 Hs 28792 Homo sapiens cDNA FU11041 fis, clone PL 7 11
408908 BE296227 Hs 250822 senne/threonine kinase 15 7 11
408660 AA525775 Hs 292523 ESTs, Moderately similar to PC4259 fem 7 10
453688 AW381270 Hs 194110 hypothetical protein PRO2730 702
426890 AA393167 Hs 41294 ESTs 698
404440 NA 697
426642 AW068223 Hs 171581 ubiquitin C-terminal hydrolase UCH37 696
431723 AW058350 Hs 16762 Homo sapiens mRNA, cDNA DKFZp564B2062 (f 695
413833 Z15005 Hs 75573 centromere protein E (312kD) 694
426249 F05422 Hs 168352 nucleopoπn-like protein 1 694
441421 AA356792 Hs 334824 hypothedcal protein FU 14825 692
400298 AA032279 Hs 61635 six transmembrane epithelial andgen of 685
423903 M57765 Hs 1721 interieukin 11 684
431041 AA490967 Hs 197955 KIAA0704 protein 674
417256 U94332 Hs 81791 tumor nxrosis fxtor rxeptor superfami 6 74
426921 AA037145 Hs 172865 cleavage sdmuladon fxtor, 3' pre-RNA, 670
407771 AL138272 Hs 62713 ESTs 669
433393 AF038564 Hs 98074 itchy (mouse homolog) E3 ubiquitin prote 6 66
407162 N63855 Hs 142634 zinc finger protein 664
411343 U77949 Hs 69563 CDC6 (cell division cycle 6, S cerevisi 664
427920 Z11502 Hs 181107 annexin A13 659
450159 AI702416 Hs 200771 ESTs, Moderately simila to A Chan A, T 658
427401 U20582 Hs 2149 xtm like protein 655
447102 BE167434 Hs 98471 ESTs, Weakly simila to T18712 hypothed 654
431806 AF186114 Hs 270737 tumor nxrosis fxtor (ligand) superfami 654
435159 AA668879 Hs 116649 ESTs 654
440209 H05049 Hs 22269 neurexin 3 654
418134 AA397769 Hs 86617 ESTs 650
451807 W52854 Hs 27099 hypothetical protein FLJ 23293 simila to 647
434894 AW977850 Hs 23856 hypothedcal protein MGC5297 640
422505 AL120862 Hs 124165 ESTs 634
426010 AA136563 Hs 1975 hypothetical protem FU210O7 6 32
414696 AF002020 Hs 76918 Niemann-Pick disease, type C1 6 31
408380 AF123050 Hs 44532 diubiquidn 631
420218 AW958037 Hs 286 nbosomal protein L4 6 29
405817 NA NA 6 28 406747 AI925153 Hs 217493 annexin A2 624
448743 AB032962 Hs 21896 KIAA1136 protein 6 24
434636 AA083764 Hs 6101 hypothetical protein MGC3178 6 20
424602 AK002055 Hs 151046 hypothetical protein FU11193 617
412661 N32860 Hs 24611 ESTs, Weakly simila to I54374 gene NF2 6 17
401644 NA 616
423248 AA3801 7 Hs 125845 nbulose-5phosphate-3-epιmerase 613
427335 AA448542 Hs 251677 G andgen 78 6 12
450375 AA009647 Hs 8850 a dismtegnn and metalloproteinase doma 607
422420 U03398 Hs 1524 tumor nxrosis fxtor (ligand) superfami 606
419752 AA249573 Hs 152618 ESTs, Moderately simila to ZN91 HUMAN Z 606
413573 AI733859 Hs 149089 ESTs 606
408758 NM 003686 Hs 47504 exonuclease 1 602
444188 AI393165 Hs 699 pepddylprolyl isomerase B (cyctophilin 602
407746 AK001962 Hs 38114 hypothedcal protein FU11100 600
446364 AB006624 Hs 14912 KIAA0286 protein 598
418939 AW630803 Hs 89497 lamm B1 590
424639 AI917494 Hs 9812 Homo sapiens cDNA FU14388 fis, clone HE 588
434377 AW137148 Hs 306593 Homo sapiens cDN A FU 11382 fis, clone HE 586
419863 AW952691 Hs 93485 Homo sapiens mRNA, cDNA DKFZp761D191 (fr 584
430849 AI940727 Hs 270556 ESTs, Highly simila to AF156779 1 ASB-4 582
428822 W28418 Hs 30715 potassium voltage-gated channel, Isk-rel 580
448776 BE302464 Hs 30057 MRS2 (S cerevιsιae)-lιke, magnesium hom 574
442957 AI949952 Hs 49397 ESTs 572
444577 AI207721 Hs 11393 RAD51 (S cerevisiae) homolog C 5 2
424565 AW102723 Hs 75295 guanylate cyclase 1 , soluble, alpha 3 571
433330 AW207084 Hs 132816 hypothedcal protein MGC14801 568
428618 AA885360 Hs 160199 NADPH oxidase, EF hand calcium-binding d 568
432867 AW016936 Hs 233364 ESTs 564
412140 AA219691 Hs 73625 RAB6 interxdng, kinesm-like (rabkmes 563
433133 AB027249 Hs 104741 PDZ-bindmg kinase, T-cell oπgmated pr 562
418379 AA218940 Hs 137516 fidgetin-like 1 557
434551 BE387162 Hs 280858 ESTs, Highly similar to A35661 DNA excis 557
442353 BE379594 Hs 49136 ESTs, Moderately similar to ALU7 HUMAN A 556
427386 AW836261 Hs 337717 ESTs 554
425650 NM 001944 Hs 1925 desmoglem 3 (pemphigus vulgans antigen 552
428479 Y00272 Hs 184572 cell division cycle 2, G1 to S and G2 to 551
449370 AK002114 Hs 23495 hypothedcal protein FLJ 11252 550
431118 BE264901 Hs 250502 carbonic anhydrase VIII 550
423673 BE003054 Hs 1695 matπx metalloproteinase 12 (mxrophage 550
453931 AL121278 Hs 25144 ESTs 549
409044 AI129586 Hs 33033 hypothedcal protein FU14623 548
436291 BE568452 Hs 5101 protein regulator of cytokinesis 1 545
448336 R53848 Hs 44976 ESTs 544
454018 AW016892 Hs 100855 ESTs 542
457030 AI301740 Hs 173381 dihydropynmidmase-like 2 542
412246 AI160873 Hs 69233 zinc finger protein 540
432193 AA372264 Hs 273193 hypothetical protein FLJ 10706 540
437319 BE410958 Hs 56406 Homo sapiens cDNA FLJ13549 fis, clone PL 540
427660 AI741320 Hs 114121 Homo sapiens cDNA FU23228 fis clone C 540
452862 AW378065 Hs 8687 ESTs 538
409327 L41162 Hs 53563 collagen, type IX, alpha 3 536
412811 H06382 Hs 21400 ESTs 534
448390 AL035414 Hs 21068 hypothedcal protein 532
428187 AI687303 Hs 285529 G protein-coupled rxeptor 49 530
450434 AA166950 Hs 195870 hypothedcal protein FU14991 529
434265 AA846811 Hs 130554 Homo sapiens cDNA FU23089 fis, clone L 528
407811 AW190902 Hs 40098 cysteine knot superfamily 1, BMP antagoπ 527
446638 AL133063 Hs 15783 Homo sapiens mRNA, cDNA DKFZp434P1115 (f 526
444743 AA045648 Hs 301957 nudix (nucleoside diphosphate linked moi 525
424902 NM_003866 Hs 153687 inositol polyphosphate-4-phosphatase ty 524
452150 W42490 Hs 260844 ESTs 524
432865 AI753709 Hs 152484 ESTs, Weakly similar to I38022 hypothed 5 24
453382 AA709285 Hs 5997 hypothedcal protein FU13078 522
447048 AW393O80 Hs 228320 hypothedcal protein FU23537 522
426518 Z43039 Hs 170198 KIAA0009 gene product 522
453884 AA355925 Hs 36232 KIAA0186 gene product 520
429625 AA455568 Hs 193814 ESTs 520
413472 BE242870 Hs 75379 solute earner family 1 (glial high affi 520
449318 AW236021 Hs 78531 Homo sapiens, Simila to RIKEN cDNA 5730 5 19
444059 R69743 Hs 116774 integnn, alpha 1 5 18
409432 D49372 Hs 54460 small inducible cytokine subfamily A (Cy 517
412719 AW016610 Hs 129911 ESTs 5 15
444342 NM 014398 Hs 10887 similar to lysosome-assxiated membrane 514
425739 T19016 Hs 159410 molybdopterin synthase suffurylase 5 12
452198 AI097560 Hs 61210 ESTs, Weakly simila to I38022 hypothed 5 12
445657 AW612141 Hs 279575 Homo sapiens G-protem coupled rxeptor 5 10
434699 AA643687 Hs 149425 Homo sapiens cDNA FU11980 fis clone HE 509
424296 AI631874 Hs 155140 casein kinase 2, alpha 1 polypepdde 508
441645 AI222279 Hs 201555 ESTs, Weakly similar to T23406 hypotheti 506
412723 AA648459 Hs 335951 hypothetical protein AF301222 506
448811 AI590371 Hs 174759 ESTs 505
447342 AI199268 Hs 19322 Homo sapiens, Similar to RIKEN cDNA 2010 504 411835 U29343 Hs 72550 hyaluronan-mediated odlity rxeptor (R 504
421373 AA808229 Hs 167771 ESTs 504
448991 AW771565 Hs 189594 ESTs 502
429370 C19097 Hs 89709 glutamate-cysteme ligase modifier subu 500
454036 AA374756 Hs 93560 Homo sapiens mRNA for KIAA1771 protein. 498
405770 NA 496
421110 AJ250717 Hs 1355 cathepsin E 496
452588 AA889120 Hs 110637 homeo box A10 492
433159 AB035898 Hs 150587 kinesm-like protein 2 491
420952 AA282067 Hs 88972 ESTs, Moderately similar to A46010 X-lin 488
408321 AW405882 Hs 44205 cortistadn 487
441801 AW242799 Hs 86366 ESTs 484
450568 AL050078 Hs 25159 Homo sapiens cDNA FU10784 fis, clone NT 483
452909 NM 015368 Hs 30985 pannexin 1 482
409799 D11928 Hs 76845 phosphoseπne phosphatase-like 482
451105 AI761324 gb wι60b11 x1 NCI CGAP_Co16 Homo sapiens 480
417168 AL133117 Hs 81376 Homo sapiens mRNA, cDNA OKFZp586L1121 (f 480
418203 X54942 Hs 83758 CDC28 protein kinase 2 480
418994 AA296520 Hs 89546 selxdn E (endothelial adhesion molxul 478
436982 AB018305 Hs 5378 spondin 1, (f-spondm) extrxellular mat 478
432874 W94322 Hs 279651 melanoma inhibitory activity 478
440351 AF030933 Hs 7179 RAD1 (S pombe) homolog 478
431956 AK002032 Hs 272245 Homo sapiens cDNA FU11170 fis, clone PL 477
442980 AA857025 Hs 8878 kinesm-like 1 476
432437 W07088 Hs 293685 ESTs 476
414869 AA157291 Hs 21479 ubinuclein 1 474
446254 BE179829 Hs 179852 Homo sapiens cDNA FLJ12832 fis, ctone NT 474
418380 AA425473 Hs 84429 KIAA0971 protein 474
419343 AA456245 Hs 85603 down-regulated by Ctnnbl, a 474
418478 U38945 Hs 1174 cyclin-dependent kinase inhibitor 2A (me 472
425813 AA364136 Hs 210553 hypothetical protein DKFZp761H72 4 71
425071 NM 013989 Hs 154424 deiodmase todothyronine, type II 4 71
412733 AA984472 Hs 74554 KIAA0080 protein 468
444325 AW152618 Hs 16757 ESTs 466
407638 AJ404672 Hs 334483 hypothetical protein FU23571 466
430345 AK000282 Hs 239681 hypothedcal protein FU20275 4 66
428330 L22S24 Hs 2256 matπx metalloproteinase 7 (matnlysm, 464
449448 D60730 Hs 57471 ESTs 462
409732 NM 016122 Hs 56148 NY-REN-58 antigen 462
432415 T16971 Hs 289014 ESTs, Weakly similar to A43932 mucin 2 p 462
421987 AI133161 Hs 286131 CGI-101 protein 460
430217 N47863 Hs 336901 πbosomal protein S24 4 58
429597 NM 003816 Hs 2442 a dismtegnn and metalloproteinase doma 457
425932 M81650 Hs 1968 εemeπogelin I 4 57
408728 AL137379 Hs 47125 hypothedcal protein FLJ 13912 456
428434 AW363590 Hs 65551 Homo sapiens, Simila to DNA segment, Ch 4 55
451254 AI571016 Hs 172967 ESTs 454
422426 W79117 Hs 58559 ESTs 454
439483 T69980 Hs 58323 Homo sapiens cDNA FU11613 fis, clone HE 453
435420 AI928513 Hs 59203 ESTs 4 53
447519 U46258 Hs 339665 ESTs 452
424176 AL137273 Hs 142307 hypothedcal protein 4 52
414812 X72755 Hs 77367 monokine induced by gamma interferon 4 51
438069 N80701 Hs 33790 ESTs 4 50
450096 AI682088 Hs 79375 holxaboxylase synthetase (bιodn-[prop 450
438159 Z83947 gb H sapiens mRNA, ctone CD 117 450
433925 AI183551 Hs 26481 SBBI26 protein 448
417866 AW067903 Hs 82772 collagen, type XI, alpha 1 448
433384 AI021992 Hs 124244 ESTs 447
421863 AI952677 Hs 108972 Homo sapiens mRNA cDNA DKFZp434P228 (fr 447
453941 U39817 Hs 36820 Bloom syndrome 445
423401 NM 001992 Hs 128087 ∞aguladon fxtor II (thrombin) recepto 444
430510 AWΪ62916 Hs 241576 hypothetical protein PR02577 443
424084 AI940675 Hs 20914 hypothetical protein FU 23056 442
459587 AA031956 gb zk15e04 s1 Soares_pregnant uterus NbH 442
417956 AA210704 Hs 190465 ESTs 442
449433 AI672096 Hs 9012 ESTs, Weakly similar to S26650 DNA-bmdi 442
421477 AI904743 Hs 104650 hypothedcal protein FU 10292 442
406687 M31126 Hs 272620 pregnancy spxific bela-1-glycoproteιn 9 441
451813 NM 016117 Hs 27182 phospholipase A2-xdvatιng protein 441
415091 AL044872 Hs 77910 3-hydroxy-3-methylglutaιyl-Coenzyme A sy 440
425142 AW954397 Hs 154762 HIV-1 rev binding protein 2 440
441720 AI346487 Hs 28739 ESTs 440
409683 U33317 Hs 711 defensin alpha 6, Paneth cell-spxific 439
411571 AA122393 Hs 70811 hypothedcal protein FU20516 438
430044 AA464510 Hs 152812 ESTs 437
436246 AW450963 Hs 119991 ESTs 437
409582 R27430 Hs 271565 ESTs 4 37
453652 AW009640 Hs 28368 ESTs, Moderately simila to S65657 alpha 435
425211 M18667 Hs 1867 progastπcsin (pepsinogen C) 434
448692 AW013907 Hs 167531 melhylcrotonoyl-Coenzyme A carboxylase 2 434
409459 D86407 Hs 54481 low density lipoprotein receptor-related 434
442470 AW273860 Hs 5759 ESTs 433 441894 AA134329 Hs 24170 Homo sapiens clone IMAGE 3685398. mRNA. 432
422867 L32137 Hs 1584 cartilage oligomeπc matrix protein (pse 431
436396 AI683487 Hs 152213 wingless-type MMTV integradon site fami 431
433397 AW079766 Hs 134880 ESTs, Weakly similar to unnamed protein 430
417576 AA339449 Hs 82285 phosphoπbosylglycinamide forniyltransfer 429
413278 8E563085 Hs 833 interferon-stimulated protein 15 kDa 429
451592 AI805416 Hs 213897 ESTs 428
453900 AW003582 Hs 226414 ESTs, Weakly similar to ALU8.HUMAN ALU S 428
422892 AA988176 Hs 121553 hypothedcal protein FU20641 426
431699 NM_001173 Hs 267831 Rho GTPase xtivadng protein 5 426
428389 AW135714 Hs 283127 ESTs, Weakly simila to T19201 hypothed 4 24
410361 BE391804 Hs 62661 guanylate binding protein 1, interferoπ- 423
409913 BE243842 Hs 283077 centrosomal P4 1-ass∞ιated protein, uπc 4 22
445537 AJ245671 Hs 12844 EGF-like-doman, muldple 6 421
445640 AW969626 Hs 31704 ESTs, Weakly similar to KIAA0227 [H sapi 420
422232 D43945 Hs 113274 transcnpdon fxtor EC 4 18
442655 AW027457 Hs 30323 ESTs, Weakly simila to B34087 hypothed 418
444381 BE387335 Hs 283713 ESTs, Weakly similar to S64054 hypothed 416
434217 AW014795 Hs 23349 ESTs 416
413384 NM_000401 Hs 75334 exostoses (muldple) 2 414
407768 AW002841 Hs 29475 ESTs 4 14
419168 AI336132 Hs 33718 Homo sapiens cDNA FU 12641 fis, clone NT 413
408165 AL137573 Hs 43143 Homo sapiens mRNA cDNA DKFZp564A2463 (f 412
443691 AI081724 Hs 17267 ESTs 412
409640 U78722 Hs 55481 zinc finger protein 165 412
438176 AW138970 Hs 122113 ESTs 10
435532 AW291488 Hs 117305 Homo sapiens, clone IMAGE 3682908, mRNA 410
419606 AW294795 Hs 198529 ESTs 408
452824 W27643 Hs 73965 splicing fxtor, argmine/senne-πch 2 408
414152 NM_003248 Hs 75774 thrombospondin 4 408
418688 T85017 Hs 1192 KIAA0074 protein 407
404253 NA 406
421741 AK001879 Hs 107527 hypothedcal protein FU11017 406
428218 AA424266 Hs 123642 EphA3 406
428858 AA436760 gb zv67d11 rl Soares_.otal_fetus.Nb2HF8_ 406
428336 AA503115 Hs 183752 microsemmoprotein, beta- 405
442875 BE623003 Hs 23625 Homo sapiens clone TCCCTA00142 mRNA sequ 404
421841 AA908197 Hs 108850 MAK-related kinase 404
451177 AI969716 Hs 13034 ESTs 404
425188 AK002052 Hs 155071 hypothedcal protein FU11190 404
421262 AA286746 Hs 9343 Homo sapiens cDNA FU 14265 fis, clone PL 403
424634 NM 003613 Hs 151407 cartilage intermediate layer protein, nu 402
438777 AA825487 Hs 142179 ESTs 402
423343 AA324643 Hs 246106 ESTs 402
425788 BE466417 Hs 231899 ESTs, Weakly similar to rab3 effxtor-li 402
409928 AL137163 Hs 57549 hypothedcal protein dJ473B4 401
406671 AA129547 Hs 285754 met proto-oncogene (hepatxyte growth fa 401
442973 BE567665 Hs 288550 Homo sapiens cDNA FU23156 fis, clone L 400
433225 AW816515 Hs 173540 ATPase, Class V, type 10D 400
411765 H43346 gb yp09a04 r1 Soares breast 3NbHBst Homo 400
452022 AW072330 Hs 293875 ESTs 400
451806 NM.003729 Hs 27076 RNA 3'-termιπal phosphate cyclase 399
423541 AA296922 Hs 129778 gastrointestinal peptide 399
414132 AI801235 Hs 48480 ESTs 399
452453 AI902519 gb QV BT009-101198-051 BT009 Homo sapien 398
418454 AA315308 Hs 195870 hypothedcal protein FU14991 398
430134 BE380149 Hs 105223 ESTs, Weakly similar to T33188 hypothed 398
453160 AI263307 Hs 239884 H2B histone family, member L 397
417235 AA810278 Hs 24250 ESTs 396
425398 AL049689 Hs 156369 hypothetical protein similar to tenascin 395
414136 AA812434 Hs 119023 SMC2 (structural maintenance of chromoso 394
436608 AA628980 Hs 192371 down syndrome cπtical region protein DS 394
431753 X76029 Hs 2841 πeuromedm U 394
453161 AA628608 Hs 61656 ESTs 394
454821 AW833504 gb QV4-TT0008-091199-025f03 TT0008 Homo 394
427961 AW293165 Hs 143134 ESTs 394
439453 BE264974 Hs 6566 thyroid hormone rxeptor interxtor 13 393
409564 AA045857 Hs 54943 fracture callus 1 (rat) homolog 393
418396 AI765805 Hs 26691 ESTs 392
451411 AA017492 Hs 135655 EST 392
445885 AI734009 Hs 127699 KIAA1603 protein 392
407698 AA058900 Hs 32646 hypothetical protein FU21901 391
442896 R37725 Hs 261108 ESTs 390
433361 AW469373 Hs 300141 πbosomal protein L39 390
419926 AW900992 Hs 93796 DKFZP586D2223 protein 389
413775 AW409934 Hs 75528 nucledar GTPase 388
452943 BE247449 Hs 31082 hypothetical protein FU 10525 386
428549 AA430064 Hs 220929 Homo sapiens cDNA FLJ14369 fis, clone HE 386
456120 AA535244 Hs 78305 RAB2, member RAS oncogene family 386
452194 AI694413 Hs 332649 olfxtorγ rxeptor, family 2, subfamily 385
421247 BE391727 Hs 102910 general transcπption fxtor IIH, polype 385
417720 AA205625 Hs 208067 ESTs 385
418811 AK001407 Hs 88663 hypothetical protein FU 10545 384 430899 BE018217 Hs 183528 hypothedcal protein FU14906 384
421246 AW582962 Hs 102897 CGI-47 protein 383
407366 AF026942 gb Homo sapiens cιg33 mRNA, partial sequ 383
428698 AA852773 Hs 334838 KIAA1866 protein 382
435202 AI971313 Hs 170204 KIAA0551 protein 382
454074 R63503 Hs 28419 ESTs 382
448917 AI683598 Hs 201615 ESTs 382
410507 AA355288 Hs 40834 transitional epithelia response protein 382
452571 W31518 Hs 34665 ESTs 382
445663 AI247343 Hs 149232 ESTs 382
450701 H39960 Hs 288467 Homo sapiens cDNA FU 12280 fis, clone MA 380
423025 AA831267 Hs 12244 hypothedcal protein FU20097 380
425656 AB018284 Hs 158688 KIAA0741 gene product 380
407168 R45175 Hs 117183 ESTs 379
403422 NA NA 379
425492 AL021918 Hs 158174 zinc finger protein 184 (Kruppel-like) 379
432239 X81334 Hs 2936 matπx metalloproteinase 13 (collagenase 379
457325 AA744550 Hs 136345 ESTs 378
433800 AI034361 Hs 135150 lung type-l cell membrane-assxiated gly 377
428865 BE544095 Hs 164960 BarH-dke ho ∞box 1 376
424188 AW954552 Hs 142634 zinc finger protein 375
424638 AI472106 Hs 49303 Homo sapiens cDNA FU11663 fis, clone HE 375
451099 R52795 Hs 25954 interieukin 13 receptor, alpha 2 375
448105 AW591433 Hs 298241 Transmembrane protease, senne 3 374
452785 AL359942 Hs 296434 erythroid differendadon and deπudead 374
459000 AA903705 Hs 4190 Homo sapiens cDNA FU 23269 fis, clone C 374
432653 N62096 Hs 293185 ESTs, Weakly similar to JC7328 ammo xi 373
409632 W74001 Hs 55279 senne (or cysteine) proteinase inhibito 373
414883 AA926960 Hs 334883 CDC28 protein kinase 1 373
415064 AA159804 Hs 149305 hypothedcal protein MGC2603 372
432198 AI475306 Hs 50458 ESTs 372
458194 AW383618 Hs 265459 ESTs, Moderately simila to ALU2 HUMAN A 372
415263 AA948033 Hs 130853 ESTs 371
408296 AL117452 Hs 44155 DKFZP586G1517 protein 371
408460 AA054726 Hs 285574 ESTs 371
437496 AA452378 Hs 170144 Homo sapiens mRNA, cDNA DKFZp547J125 (fr 370
443486 NM.003428 Hs 9450 zinc finger protein 84 (HPF2) 368
432021 AA524470 Hs 58753 ESTs 368
420092 AA814043 Hs 88045 ESTs 368
414923 AW445008 Hs 77637 homeo box A4 368
429432 AI678059 Hs 202676 synaptonemal complex protein 2 368
435496 AW840171 Hs 265398 ESTs, Weakly simila to transformaboπ-r 367
430544 AA481066 Hs 105153 Homo sapiens, clone IMAGE 3461987, mRNA, 367
432542 AW083920 Hs 16098 claudin 2 367
410782 AW504860 Hs 288836 hypothedcal protein FU 12673 366
421106 AA877124 Hs 172844 ESTs 364
439107 AL046134 Hs 13944 adrenergic, beta, receptor kinase 2 364
418735 N48769 Hs 44609 ESTs 364
411598 BE336654 Hs 70937 H3 histone family, member A 363
424687 J05070 Hs 151738 matπx metalloproteinase 9 (gelatmase B 363
436411 AW67-4352 gb ba63c07 y1 NIH_MGC_12 Homo sapiens cD 363
429774 AI522215 Hs 50883 KIAA1804 protein 362
448844 AI581519 Hs 177164 ESTs 361
402473 AB033035 Hs 51965 KIAA1209 protein 361
441085 AW136551 Hs 181245 Homo sapiens cDNA FU 12532 fis, clone NT 361
429534 AW976987 Hs 163327 ESTs, Weakly simila to 2109260A B cell 360
414706 AW340125 Hs 76989 KIAA0097 gene product 360
436211 AK001581 Hs 334828 hypothetical protein FU10719, KIAA1794 3,59
422938 NM 001809 Hs 1594 centromere protein A (17kD) 359
451381 BE241831 Hs 172330 hypothetical protein MGC2705 3 58
428664 AK001666 Hs 189095 similar to SALL1 (sal (Drosophιla)-lιke 358
424345 AK001380 Hs 145479 Homo sapiens cDNA FLJ10518 fis, clone NT 358
440717 AA904527 Hs 42207 ESTs 358
450698 W31489 Hs 95044 ESTs, Weakly simila to I38022 hypotheti 358
423675 AI990509 Hs 131342 small inducible cytokine subfamily A (Cy 3 58
424882 AI379461 Hs 153636 fa upstream element (FUSE) binding prot 357
410784 AW803201 gb IL2-UM0077-070500-080-E06 UM0077 Homo 355
411096 U80034 Hs 68583 mitxhondπal intermediate peptidase 355
430294 AI538226 Hs 32976 guanine nuclxdde binding protein 4 354
439225 AA192669 Hs 45032 ESTs 354
429183 AB014604 Hs 197955 KIAA0704 protein 354
419948 AB041035 Hs 93847 NADPH oxidase 4 353
443426 AF098158 Hs 9329 chromosome 20 open reading frame 1 352
408556 U49516 Hs 46362 5hydroxytryptamme (serotonin) rxeptor 352
417048 AI088775 Hs 55498 geranylgeranyl diphosphate synthase 1 352
432101 AI918950 Hs 123642 EphA3 352
419216 AU076718 Hs 164021 small inducible cytokine subfamily B (Cy 351
444754 T83911 Hs 11881 transmembrane 4 superfamily member 4 351
422093 AF151852 Hs 111449 CGI-94 protein 350
404766 NA NA 350
441513 AW014557 Hs 112420 ESTs 350
444301 AK000136 Hs 10760 asρoπn (LRR class 1) 350
417315 AI080042 Hs 336901 πbosomal protein S24 350 407182 AA312551 Hs 230157 ESTs 349
443204 AW205878 Hs 29643 Homo sapiens cDNA FU13103 fis. clone NT 349
432289 AI860145 Hs 55118 ESTs 349
453644 AI813444 Hs 42197 ESTs 348
427986 N4521 Hs 282387 Homo sapiens cDNA FLJ21837 fis, clone H 348
405466 NA 348
410804 U64820 Hs 66521 Mxhado-Joseph disease (spmxerebella 348
430357 AW976789 Hs 165607 ESTs 346
418428 Y12490 Hs 85092 thyroid hormone receptor terxtor 11 346
422260 AA315993 Hs 105484 regenerating gene type IV 346
421928 AF013758 Hs 109643 polyadenylate binding protem-interxdn 346
451403 AA885569 Hs 40919 Homo sapiens cDNA FU14511 fis, clone NT 346
406117 NA 346
458242 BE299588 Hs 28465 Homo sapiens cDNA FU21869 fis, ctone H 346
408562 AI436323 Hs 31141 Homo sapiens mRNA for KIAA1568 protein. 345
440105 AA694010 Hs 6932 Homo sapiens clone 23809 mRNA sequence 345
443767 BE562136 Hs 9736 proteasome (prosome, mxropaiπ) 26S subu 345
426320 W47595 Hs 169300 transforming growth fxtor, beta 2 345
444478 W07318 Hs 240 M-phase phosphoprotein 1 345
425904 AI805990 Hs 82238 POP4 (prxessmg of precurso , S cerev 344
416702 AA186428 Hs 85591 ESTs 344
448668 AI560305 Hs 199852 ESTs 3.42
410004 AI298027 Hs 5057 carboxypepddase D 342
428771 AB028992 Hs 193143 KIAA1069 protein 342
446619 AU076643 Hs 313 sxreted phosphoprotein 1 (osteopondn. 342
429628 H09604 Hs 13268 ESTs 340
448816 AB033052 Hs 22151 KIAA1226 protein 340
456032 AW957446 Hs 301711 ESTs 339
439635 AA477288 Hs 94891 hypothetical protein FU22729 339
414275 AW970254 Hs 889 Chaot-Leyden crystal protein 338
447207 AA442233 Hs 17731 hypothedcal protein FU 12892 338
416057 AI927382 Hs 29857 ESTs 338
430704 AW813091 Hs 335799 ESTs 3 38
423600 AI633559 Hs 310359 ESTs 338
453891 AB037751 Hs 36353 Homo sapiens mRNA full length insert cDN 338
430178 AW449612 Hs 152475 ESTs 337
417791 AW965339 Hs 111471 ESTs 3 37
408867 AA437199 Hs 656 cell division cycle 25C 337
449802 AW901804 Hs 23984 hypothedcal protein FU20147 337
457003 S78234 Hs 172405 cell division cycle 27 336
458076 R80061 Hs 164478 hypothedcal protein FLJ21939 similar to 336
436203 BE384982 Hs 5076 Homo sapiens cDNA FU22128 fis, ctone H 336
418782 AI792648 Hs 14665 ESTs 334
449722 BE280074 Hs 23960 cycl B1 334
447984 AI457263 Hs 37244 ESTs 334
451103 R52804 Hs 25956 DKFZP564D206 protein 334
408812 BE397160 Hs 254763 ESTs, Weakly simila to A42442 integnn 334
448305 AA625207 Hs 264915 Homo sapiens cDNA FU 12908 fis, ctone NT 334
418849 AW474547 Hs 53565 Homo sapiens PIG-M mRNA for mannosyltran 333
450531 AW301032 Hs 203800 ESTs 332
411263 BE297802 Hs 69360 kinesm-like 6 (mitodc centromere-assx 3 32
416530 U62801 Hs 79361 kallikrein 6 (neurosm, zyme) 331
425746 NM 001701 Hs 159440 bile xid Coenzyme A ammo xid N-xylt 330
421037 AI684808 Hs 197653 ESTs 330
430388 AA356923 Hs 240770 nuclear cap binding protein subunit 2, 2 330
433132 AB026264 Hs 284245 hypothetical protein IMPACT 330
447078 AW885727 Hs 301570 ESTs 330
402408 NA NA 329
437044 AL035864 Hs 69517 cDNA for differentially expressed C016 g 329
423126 AA322245 Hs 290165 ESTs 328
446223 BE300091 Hs 119699 hypothetical protein FU12969 3 27
451917 AW391351 Hs 50820 Homo sapiens unknown mRNA 327
419335 AW9601 6 Hs 284137 hypothedcal protein FU12888 326
411078 AI222020 Hs 182354 CocoaCnsp 326
419790 U79250 Hs 93201 glycerol-3-phosphate dehydrogenase 2 (mi 326
427119 AW880562 Hs 114574 ESTs 326
400250 NA NA 326
429044 AI261490 Hs 145527 ESTs 325
451050 AW937420 Hs 69662 ESTs 324
447425 AI963747 Hs 18573 xylphosphatase 1, erythrocyte (∞mmon) 324
410389 AW954049 Hs 8177 ESTs, Weakly similar to PIHUB6 salivary 323
416565 AW000960 Hs 44970 endoplasmic redculum resident protein 5 322
442028 AI239437 Hs 48945 ESTs 322
409110 AA191493 Hs 48778 mban protein 3 22
418926 AA232658 Hs 105794 UDP-glucose gly∞protein glucosyltraπsfe 322
408353 BE439838 Hs 44298 mitxhondπal πbosomal protein S17 321
445417 AK001058 Hs 12680 Homo sapiens cDNA FU10196 fis, clone HE 320
442979 AW440782 Hs 174743 ESTs 3 20
439292 AA090421 Hs 5555 hypothedcal protein MGC5347 320
440953 AI683036 Hs 124135 Homo sapiens cDNA FU13051 fis, clone NT 320
447020 T27308 Hs 16986 hypothedcal protein FU11046 3 20
451181 AI796330 Hs 207461 ESTs 319
422809 AK001379 Hs 121028 hypothedcal protein FU10549 3 19 411573 AB029000 Hs 70823 KIAA1077 protein 319
424539 L02911 Hs 150402 xdvin A rxeptor, type I 3 18
443179 AI928402 Hs 6933 hypothetical protein FU12684 3 18
452545 N31940 Hs 14434 ESTs, Weakly similar to I38022 hypotheti 3 18
433024 AA573847 Hs 26549 KIAA1708 protein 318
414737 AM 60386 Hs 125087 ESTs 318
444230 H95537 Hs 146067 ESTs 3 18
419741 NM 007019 Hs 93002 ubiquitin earner protein E2-C 3 17
428945 AW192803 Hs 98974 ESTs, Weakly similar to S65824 reverse t 317
424085 NM 002914 Hs 139226 replicadon fxtor C (xdvator 1) 2 (40 3 17
418661 NM_001949 Hs 1189 E2F transcnpdon fxtor 3 317
443598 AW499970 Hs 14822 ESTs, Weakly simila to I78885 senne/th 316
413516 BE145907 gb MR0-HT0208-221299-204-e12 HT0208 Homo 3 16
434389 AA971235 Hs 128098 ESTs 316
431322 AW970622 gb EST382704 MAGE resequences, MAGK Homo 3 15
432158 W33165 Hs 22983 UDP-glucose glycoprotein glucosylfransfe 315
453331 AI240665 Hs 8895 ESTs 3 15
410286 AI739159 Hs 61898 DKFZP586N2124 protein 3 14
408687 AL110280 Hs 301152 Homo sapiens mRNA, cDNA DKFZp434F053 (fr 3 14
422789 AK001113 Hs 120842 hypothedcal protein FU10251 314
419078 M93119 Hs 89584 insulmoma-assxiated 1 3 14
414080 AA135257 Hs 47783 B aggressive lymphoma gene 314
451525 AW001757 Hs 14005 ESTs 313
453775 NM 002916 Hs 35120 replication fxtor C (xdvator 1) 4 (37 3 13
433183 AF231338 Hs 222024 transcnpdon fxtor BMAL2 312
424783 AA913909 Hs 153088 TATA box binding protein (TBP)-assxιa(e 3 12
413170 BE068819 gb MRO-BT0374-220300-001-b03 BT0374 Homo 312
437181 AI306615 Hs 125343 ESTs, Weakly similar to KIAA0758 protein 312
442991 BE281238 Hs 8886 hypothedcal protein FU20424 3 11
453867 AI929383 Hs 33032 hypothedcal protein DKFZp434N185 311
437641 AA811452 Hs 291911 ESTs 3 10
428651 AF196478 Hs 188401 annexin A10 309
427927 AI879165 Hs 2227 CCAAT/enhancer binding protein (C/EBP), 309
419196 AF110908 Hs 297660 TNF rxeptor-assxiated fxtor 3 309
414569 AF109298 Hs 118258 prostate cancer associated protein 1 309
408633 AW963372 Hs 46677 PRO20 0 protein 309
403381 NA 308
444619 BE538082 Hs 8172 ESTs, Moderately similar to A46010 X-lm 308
422363 T55979 Hs 115474 replication fxtor C (xdvator 1) 3 (38 308
434138 AA625804 gb zu86h01 s1 Soares_tesds_NHT Homo sap 307
425322 U63630 Hs 155637 protein kinase, DNA-xdvated, catalytic 307
436556 AI364997 Hs 7572 ESTs 307
427043 AA397679 Hs 3991 ESTs 306
443055 AV653742 Hs 15536 hypothedcal protein DKFZp761J139 306
419229 AI827237 Hs 282884 ESTs 305
414718 H95348 Hs 107987 ESTs 305
439737 AI751438 Hs 41271 Homo sapiens mRNA full length insert cDN 305
448587 AI539652 Hs 28338 KIAA1546 protein 304
448595 AB014544 Hs 21572 KIAA0644 gene product 304
407201 N31998 Hs 164256 hypothedcal protein FU20657 304
423065 R96158 Hs 267130 Homo sapiens, clone MGC 5406, mRNA, comp 304
431980 AA523696 Hs 324507 hypothetical protein FU20986 304
416198 H27332 Hs 99598 hypothedcal protein MGC5338 304
429410 X98494 Hs 201676 M-phase phosphoprotein 10 (U3 small nucl 304
432140 AK000404 Hs 272688 hypothetical protein FU20397 303
441031 AH 10684 Hs 7645 fibπnogen, B beta polypepdde 303
446142 AI754693 Hs 145968 ESTs 302
402167 NA 302
402299 NA 302
417830 AW504786 Hs 122579 hypothedcal protein FU10461 302
419910 AA662913 Hs 190173 ESTs, Weakly simila to A46010 X-lmked 302
424001 W67883 Hs 137476 paternally expressed 10 301
413930 M86153 Hs 75618 RAB11 A, member RAS oncogene family 301
439924 AI985897 Hs 125293 ESTs 301
414343 AL036166 Hs 323378 ∞ated vesicle membrane protein 301
432201 AI538613 Hs 298241 Transmembrane protease, senne 3 300
445845 AI261870 Hs 145555 ESTs 300
420727 H75701 Hs 99886 complement component 4-bιndιng protein, 300
427510 Z47542 Hs 179312 small nuclea RNA xdvadng complex, po 300
403637 NA NA 300
410947 AK000305 Hs 67055 hypothedcal protein FU20298 300
413430 R22479 Hs 167073 Homo sapiens cDNA FU 13047 fis, clone NT 300
423575 C18863 Hs 163443 Homo sapiens cDNA FLJ11576 fis clone HE 299
426711 AA383471 Hs 180669 conserved gene amplified in osteosacoma 299
442204 AI635450 Hs 21914 ESTs 298
429682 NM_006306 Hs 211602 SMC1 (structural maintenance of chromoso 298
419227 BE537383 Hs 89739 cholinergic rxeptor, nicodπic, beta po 297
447233 AW246333 Hs 17901 Homo sapiens, clone IMAGE 3937015, mRNA, 297
441826 AW503603 Hs 129915 phosphotπesterase related 297
433404 T32982 Hs 102720 ESTs 296
450506 NM 004460 Hs 418 fibroblast activation protein, alpha 296
423880 BE278111 Hs 134200 DKFZP564C186 protein 296
411750 BE562298 Hs 71827 KIAA011 protein, homolog of yeast πbos 296 408155 AB014528 Hs 43133 KIAA0628 gene product 296
424131 AA335714 Hs 199665 ESTs 296
451250 AA491275 Hs 236940 hypothedcal protein FU12542 296
425154 NM.001851 Hs 154850 collagen, type IX, alpha 1 296
447829 AI433029 Hs 164104 ESTs 295
410561 BE540255 Hs 6994 Homo sapiens cDNA FU22044 fis, clone H 295
417873 BE266659 Hs 293659 Homo sapiens. Similar to RIKEN cDNA A430 295
452693 T79153 Hs 48589 zinc finger protein 228 295
407742 AF186252 Hs 38084 sulfotransferase family, cytosdic, 1C, 294
421430 AW207555 Hs 97093 Homo sapiens cDNA FU 23004 fis, clone L 2.94
407995 AI094748 Hs 100134 hypothedcal protein FU 12787 294
413281 AA861271 Hs 222024 transcnpdon fxtor BMAL2 294
452381 H23329 Hs 290880 ESTs, Weakly similar to ALU1 HUMAN ALU S 294
441020 W79283 Hs 35962 ESTs 294
425397 J04088 Hs 156346 topoisomerase (DNA) II alpha (170kD) 294
420005 AW271106 Hs 133294 ESTs 293
412530 AA766268 Hs 266273 hypothedcal protein FU 13346 293
435602 AF217515 Hs 283532 uncharxteπzed bone marrow protein BM03 293
447247 AW369351 Hs 287955 Homo sapiens cDNA FU13090 fis, ctone NT 293
443341 AW631480 Hs 8688 ESTs 292
436481 AA379597 Hs 5199 HSPC150 protein similar to ubiquidπ-con 292
410144 W07189 Hs 68185 ESTs, Weakly simila to ARL3.HUMAN ADP-R 292
434450 S78664 Hs 87 rednoblastoma-like 1 (p107) 292
450402 BE218027 Hs 89969 ESTs 292
422026 U80736 Hs 110826 tnnucleodde repeat containing 9 292
421562 AA530994 Hs 334471 ghrelin precursor 292
410434 AF051152 Hs 63668 toll-like receptor 2 292
422665 AJ011812 Hs 119018 transcnpdon fxtor NRF 291
428966 AF059214 Hs 194687 cholesterol 25-hydroxylase 290
412416 AI628253 Hs 22580 alkylglycerone phosphate synthase 290
446232 AI281848 Hs 194691 rednoic xid induced 3 290
454600 AW810001 gb MR4-ST0124-270300-005b11 ST0124 Homo 290
438018 AK001160 Hs 5999 hypothedcal protein FU 10298 290
433252 AB040957 Hs 151343 KIAA1524 protein 290
444355 BE383686 Hs 191621 ESTs, Moderately similar to ALU6.HUMAN A 290
443054 AI745185 Hs 8939 yes-βssxiated protein 65 kDa 289
421308 AA687322 Hs 192843 leucine zipper protein FKSG14 289
411643 AI924519 Hs 192570 hypothedcal protein FU22028 289
419559 Y07828 Hs 91096 πng finger protein 289
433527 AW235613 Hs 133020 ESTs 288
426274 D38122 Hs 2007 tumor nxrosis fxtor (ligand) superfami 288
406182 NA NA 288
432731 R31178 Hs 287820 fibronxdn 1 288
429274 AI379772 Hs 99206 ESTs 287
418216 AA662240 Hs 283099 AF15q14 protein 287
410166 AK001376 Hs 59346 hypothedcal protem FU10514 286
452665 AW839326 Hs 330414 ESTs, Moderately similar to S65657 alpha 286
424696 BE439547 Hs 151903 GrpE-like protein c∞haperone 286
410174 AA306007 Hs 59461 DKFZP434C245 protein 285
443640 AI872643 Hs 134218 ESTs 285
432912 BE007371 Hs 200313 ESTs 285
431611 U58766 Hs 264428 tissue spxific transplantation antigen 285
446565 D13757 Hs 311 phosphoπbosyl pyrophosphate amidotransf 285
424770 AA425562 Hs 11065 Homo sapiens HDCME13P mRNA, partial eds 284
418845 AA852985 Hs 89232 chromobox homolog 5 (Drosophila HP1 alph 284
403639 NA NA 284
451110 AI955040 Hs 265398 ESTs, Weakly similar to transformadon-r 284
416185 AW975861 Hs 47367 KIAA1785 protein 284
444665 BE613126 Hs 47783 B aggressive lymphoma gene 283
423441 R68649 Hs 278359 absent in melanoma 1 like 283
450584 AA040403 Hs 60371 ESTs 283
420191 AW003565 Hs 192323 Homo sapiens mRNA for FLJ00057 protein, 283
425599 AW366745 Hs 214140 ESTs, Weakly similar to ALU1.HUMAN ALU S 283
424408 AI754813 Hs 146428 collagen, type V, alpha 1 283
448769 N66037 Hs 38173 ESTs 282
444946 AW139205 Hs 156457 hypothetical protem FU22408 282
435347 AW01 873 Hs 116963 ESTs 282
438435 AA8071 2 Hs 42194 hypothetical protein FU22649 similar to 282
427687 AW003867 Hs 1570 histamine rxeptor H1 282
426951 AA393636 Hs 97454 ESTs 282
427970 AA418187 Hs 330515 ESTs 282
442577 AA292998 Hs 163900 ESTs 282
441016 AW138653 Hs 25845 ESTs 281
414774 X02419 Hs 77274 plasminogen xdvator, urokinase 281
417160 N76497 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbx 281
409346 AL162066 Hs 54320 hypothetical protein DKFZp762D096 281
410407 X66839 Hs 63287 carbonic anhydrβse IX 281
407137 T97307 gb ye53h05 s1 Soares fetal liver spleen 281
435849 BE305242 Hs 16098 claudin 2 280
426695 AW118191 Hs 112729 ESTs 280
428301 AW628666 Hs 98440 ESTs, Weakly similar to 138022 hypothed 280
420759 T11832 Hs 127797 Homo sapiens cDNA FU 11381 fis, ctone HE 280
421341 AJ243212 Hs 279611 deleted in malignant brain tumors 1 280 419423 026488 Hs 90315 KIAA0007 protein 279
452355 N54926 Hs 29202 G protein-coupled rxeptor 34 279
425826 U97698 Hs 159593 mucin 6, gastnc 279
457465 AW301344 Hs 122908 DNA replicadon fxtor 279
426472 BE246138 Hs 30853 ESTs 279
424081 NM.006413 Hs 139120 nbonuclease P (30kD) 278
425851 NM 001490 Hs 159642 glucosammyl (N-xetyl) transferase 1 c 278
419236 AA330447 Hs 135159 Homo sapiens CDNA FU11481 fis, clone HE 278
423430 AF112481 Hs 128501 RAD54, S cerevisiae, homolog of, B 278
410011 AB020641 Hs 57856 PFTAIRE protein kinase 1 278
453700 AB009426 Hs 560 apolipoprotein B mRNA edidng enzyme, ca 278
431250 BE264649 Hs 251377 taxol resistance associated gene 3 277
414043 AI521210 Hs 97977 ESTs 277
418054 NM_002318 Hs 83354 lysyl oxidase-like 2 277
439223 AW238299 Hs 250618 UL16 binding protein 2 276
425956 M60828 Hs 164568 fibroblast growth fxtor 7 (keradnocyte 276
437612 AA827715 Hs 105153 Homo sapiens, clone IMAGE 3461987, mRNA, 276
426119 W94997 Hs 189917 ESTs 276
459574 AI741122 Hs 101810 Homo sapiens cDNA FU 14232 fis, clone NT 276
442339 BE299668 Hs 227591 ESTs, Weakly similar to 1901303A Leu zip 276
414334 AA824298 Hs 21331 hypothedcal protein FU 10036 276
418217 AI910647 Hs 13442 ESTs 276
420022 AA256253 Hs 120817 ESTs 276
408243 Y00787 Hs 624 interieukin 8 275
421346 Z34277 Hs 103707 apomucin 275
421379 Y15221 Hs 103982 small inducible cytokine subfamily B (Cy 275
425773 N21279 Hs 237749 ESTs 275
449611 AI970394 Hs 197075 ESTs 274
424827 AI057094 Hs 96867 Homo sapiens cDNA FLJ23155 fis, clone L 274
448621 AI097144 Hs 5250 ESTs, Weakly simila to ALU1 HUMAN ALU S 274
428523 AW974540 Hs 98626 ESTs 273
410839 NM 006849 Hs 66581 protein disulfide isomerase 273
437380 AL359577 Hs 112198 Homo sapiens mRNA, cDNA DKFZp547M073 (fr 273
424641 AB001106 Hs 151413 glia maturadon fxtor, beta 273
431708 AI698136 Hs 108873 ESTs 273
436209 AW850417 Hs 254020 ESTs, Moderately similar to unnamed prot 273
441790 AW294909 Hs 132208 ESTs 273
428862 NM 000346 Hs 2316 SRY (sex determining region Y)-box 9 (ca 273
409506 NM 006153 Hs 54589 NCK adaptor protein 1 273
423482 BE280172 Hs 129228 galxtokmase 2 273
417015 M83772 Hs 80876 flavin containing monooxygenase 3 272
448165 NM_005591 Hs 202379 meiodc recombination (S cerevisiae) 11 272
448826 AI580252 Hs 293246 ESTs, Weakly simila to putadve p150 (H 272
447803 BE620578 Hs 30858 ESTs, Weakly similar to S65657 alpha-1 C- 272
429703 T93154 Hs 28705 ESTs 272
448796 AA147829 Hs 301431 endothelial zinc finger protein induced 272
410902 AW809665 gb MR4-ST0124-261099-015.07 ST0124 Homo 272
424745 AA214618 Hs 152759 xdvator of S phase kinase 272
454469 AW792775 gb CM0-UM0001-0103OO-258-g10 UM0001 Homo 272
458632 AI744445 Hs 167073 Homo sapiens cDNA FU13047 fis, clone NT 272
452012 AA307703 Hs 279766 kinesin family member 4A 272
422109 S73265 Hs 1473 gastπn-releasiπg peptide 272
438008 AA775026 Hs 203802 ESTs 272
420552 AK000492 Hs 98806 hypothedcal protein 271
427038 NM 014633 Hs 173288 KIAA0155 gene product 271
409239 AA740875 Hs 44307 ESTs, Moderately similar to 138022 hypot 271
425371 D49441 Hs 155981 mesothelm 271
439857 AA847194 Hs 232002 ESTs 271
455309 AW89401 gb RC4-NN0027-150400-012-g04 NN0027 Homo 271
439580 AF086401 Hs 293847 ESTs, Moderately simila to S65657 alpha 270
437257 AI283085 Hs 290931 ESTs, Weakly similar to YFJ7_YEAST HYPOT 270
435039 AW043921 Hs 130526 ESTs 270
438796 W67821 Hs 109590 genethonm 1 270
407013 U35637 gb Human nebulm mRNA, partial eds 270
445413 AA151342 Hs 12677 CG1 147 protein 270
418416 U11700 Hs 84999 ATPase, Cu*+ transporting, beta polypept 270
441362 BE614410 Hs 23044 RAD51 (S cerevisiae) homolog (E cod Re 269
448045 AJ297436 Hs 20166 prostate stem cell andgen 269
441868 AI400276 Hs 183485 ESTs 269
449076 AI627826 Hs 209109 ESTs 269
427528 AU077143 Hs 179565 minichromosome maintenance deficient (S 269
427617 D42063 Hs 199179 RAN binding protein 2 269
414618 AI204600 Hs 96978 hypothetical protein MGC10764 269
441350 AB020690 Hs 7782 paraneoplasdc antigen MA2 268
419310 AA236233 Hs 188716 ESTs 268
445279 R41900 Hs 22245 ESTs 268
439741 BE379646 Hs 6904 Homo sapiens mRNA full length insert cDN 268
446692 Z44514 Hs 156829 Homo sapiens mRNA for KIAA1763 protein 268
449300 AI656959 Hs 222165 ESTs 268
444585 AW170015 Hs 6594 ESTs 268
444384 BE174527 Hs 11065 Homo sapiens HDCME13P mRNA, partial eds 268
448104 AI674818 Hs 316433 Homo sapiens cDNA FU 11375 fis, clone HE 267
446839 BE091926 Hs 16244 mitodc spindle coiled-coil related prot 267 428361 NM.015905 Hs 183858 transcπpdonal intermediary fxtor 1 267
418971 AA360392 Hs 87113 ESTs 266
446152 AI292036 Hs 150028 ESTs 266
441553 AA281219 Hs 121296 ESTs 266
403548 NA 266
452699 AW295390 Hs 213062 ESTs 266
449532 W74653 Hs 271593 ESTs, Moderately similar to A47582 B-cel 266
453985 N44545 Hs 251865 ESTs 265
409956 AW103364 Hs 727 mhibin, beta A (acdvin A, xbvin AB a 265
409446 AI561173 Hs 67688 ESTs 265
422094 AF129535 Hs 272027 F-box only protein 5 265
445462 AA378776 Hs 288649 hypothedcal protein MGC3077 264
432670 AA806536 Hs 291841 ESTs 264
418634 AK000064 Hs 86905 ATPase, H+ transporting, lysosomal (vxu 264
453628 AW243307 Hs 83937 hypothedcal protein 264
442117 AW664964 Hs 128899 ESTs 264
416248 H99169 Hs 23450 mitochondπal πbosomal protein S25 264
414631 AW970130 Hs 65406 ESTs 264
423268 BE386898 Hs 131162 ESTs, Weakly simila to ALU5 HUMAN ALU S 264
413597 AW302885 Hs 117183 ESTs 263
446031 AI271704 Hs 18987 Homo sapiens BAC clone RP11-505D17 from 263
450142 AW207469 Hs 24485 chondroidn sulfate proteoglycan 6 (bama 263
436304 AA339622 Hs 108887 ESTs 263
439832 T81829 Hs 14870 Homo sapiens, Similar to hxt doman and 263
449207 AL044222 Hs 23255 nucleoponn 155kD 262
416111 AA033813 Hs 79018 chromatin assembly fxtor 1 , subunit A ( 262
414747 U30872 Hs 77204 centromere protein F (350/400kD, mitosin 262
423811 AW299598 Hs 50895 homeo box C4 262
439474 AI824060 Hs 211501 ESTs 262
417218 AA005247 Hs 285754 met proto-oncogene (hepatxyte growth fa 262
408031 AA081395 Hs 42173 Homo sapiens cDNA FLJ 10366 fis, clone NT 262
442821 BE391929 Hs 8752 transmembrane protein 4 262
418245 AA088767 Hs 83883 transmembrane, prostate androgen induced 262
447917 AL048037 Hs 164588 ESTs, Moderately similar to neuronal thr 261
424840 D79987 Hs 153479 extra spindle poles, S cerevisiae, homo 261
443268 AI800271 Hs 129445 hypothetical protein FU 12496 261
403056 R58624 Hs 2186 eukaryodc translation elongadon fxtor 261
433037 NM_014158 Hs 279938 HSPC067 protein 261
410358 AW975168 Hs 13337 ESTs, Weakly simila to unnamed protein 260
426181 AA371422 Hs 334371 hypothetical protein MGC13096 260
414853 U31116 Hs 77501 sarcoglycan, beta (43kD dystroph -assx 260
457233 AI355009 Hs 221698 ESTs 260
416049 AI970536 Hs 16603 hypothedcal protein FU13163 260
418946 AI798841 Hs 164526 ESTs 260
441891 AW129145 Hs 128076 ESTs 260
443742 AW627805 Hs 145421 ESTs 260
433868 AA612960 Hs 337300 ESTs 260
442717 R88362 Hs 180591 ESTs Weakly similar to T23976 hypothed 259
444542 AI161293 Hs 280380 aminopepddase 259
452940 AA029722 Hs 2173 fucosyltransferase 4 (alpha (1,3)fucosy 259
429170 NM 001394 Hs 2359 dual specificity phosphatase 4 259
417531 NM_003157 Hs 1087 seπne/threonine kinase 2 259
401458 NA 258
436016 AA806465 Hs 121536 Human DNA sequence from clone RP11-472E5 258
430980 AW971904 Hs 122164 diaphanous (Drosophila, homolog) 3 258
441581 BE551408 Hs 127196 ESTs 258
435693 AI033134 Hs 119887 ESTs 258
431814 BE256242 Hs 270847 delta-tubulm 258
446269 AW263155 Hs 14559 hypothedcal protein FU 10540 258
422765 AW409701 Hs 1578 bxuloviral IAP repeat-contaning 5 (sur 258
456999 AA319798 Hs 298581 eukaryodc translation elongadon fxtor 258
425234 AW152225 Hs 165909 ESTs, Weakly similar to I38022 hypotheti 258
434423 NM.006769 Hs 3844 LIM domain only 4 257
425782 U66468 Hs 159525 cell growth regulatory with EF-hand doma 257
433929 AI375499 Hs 27379 ESTs 257
414907 X90725 Hs 77597 polo (Drosophιa)-lιke kinase 257
411789 AF245505 Hs 72157 DKFZP564I1922 protein 257
435627 W88774 Hs 118370 ESTs 257
432168 AK000563 Hs 272805 hypothedcal protein FU20556 257
432375 BE536069 Hs 2962 S100 calcium-binding protein P 257
424057 AI339874 Hs 126593 ESTs 257
424315 AW614850 Hs 193384 putaladve 28 kDa protein 2 57
435663 AI023707 Hs 134273 ESTs 256
439277 R80061 Hs 164478 hypothedcal protein FU21939 similar to 256
427747 AW411425 Hs 180655 seπne/threonine kinase 12 256
438182 AW3421 0 Hs 182545 ESTs, Weakly similar to ALU1.HUMAN ALU S 256
421102 AI470093 Hs 283085 protxadheπn beta 6 256
445725 AK000956 Hs 13209 hypothetical protein FU10094 2 56
448243 AW369771 Hs 52620 integnn, beta 8 256
442881 AI023175 Hs 167022 ESTs 256
422165 AL041199 Hs 1481 histidine dxarboxylase 2 56
425843 BE313280 Hs 159627 death assxiated protein 3 256
448569 BE382657 Hs 21486 signal transducer and xdvator of trans 255 416806 NM 000288 Hs 79993 peroxisomal biogenesis fxtor 7 255
438113 AI467908 Hs 8882 ESTs 255
413374 NM.001034 Hs 75319 ribonucleotide reductase M2 polypepdde 255
448275 BE514434 Hs 20830 kinesm-like 2 255
419987 NM 005014 Hs 94070 osteomodulm 255
439929 S73205 gb insulin xdvator fxtor (human, pane 255
452240 AI591147 Hs 61232 ESTs 255
417806 AI867277 Hs 183733 ESTs 255
421482 AL135462 Hs 104715 inversin 255
456884 AA054679 Hs 155150 πbonuclease P(14kD) 255
442961 BE614474 Hs 289074 F-box only protein 22 255
411274 NM 002776 Hs 69423 kallikrein 10 255
419359 AL043202 Hs 90073 chromosome segregation 1 (yeast homolog) 254
448666 NM 014953 Hs 323346 KIAA1008 protein 254
428911 Z43846 Hs 194478 Homo sapiens mRNA cDNA DKFZp43401572 (f 254
452778 R71338 Hs 5921 Homo sapiens cDNA FU21592 fis, clone C 254
430733 AW975920 Hs 283361 ESTs 254
421184 NM 003616 Hs 102456 survival of motor neuron protein interx 254
435361 AI168596 Hs 117117 ESTs 254
452833 BE559681 Hs 30736 KIAA0124 protein 254
422330 D30783 Hs 115263 epiregulin 254
424962 NM.012288 Hs 153954 TRAM-like protein 254
430264 AA470519 gbnc71f10s1 NCI CGAP Pr1 Homo sapiens 253
447178 AW594641 Hs 192417 ESTs 253
411773 NM 006799 Hs 72026 protease, senne, 21 (tesdsin) 253
433571 AA765256 Hs 135191 ESTs, Weakly similar to unnamed protein 253
419449 H18417 Hs 57483 Homo sapiens cDNA FU14294 fis, clone PL 253
448019 AW947164 Hs 195641 ESTs, Moderately similar to I38022 hypot 253
409435 AI810721 Hs 95424 ESTs 252
417900 BE250127 Hs 82906 CDC20 (cell division cycle 20, S cerevi 252
431385 BE178536 Hs 11090 membrane-spanning 4-domams, subfamily A 252
422314 K01900 Hs 73890 interferon, alpha 8 252
441343 AI970348 Hs 132230 ESTs 252
417185 NM.002484 Hs 81469 nudeodde binding protein 1 (E coli Mm 252
401747 NA 252
448526 AB028946 Hs 21361 KIAA1023 protein 252
419488 AA316241 Hs 90691 nucleophosmin/nucleoplasmiπ 3 252
413627 BE182082 Hs 246973 ESTs 251
441285 NM 002374 Hs 167 microtubule-assxiated protein 2 251
446921 AB012113 Hs 16530 small inducible cytokine subfamily A (Cy 251
429357 AA779725 Hs 164589 ESTs 251
443171 BE281128 Hs 9030 TONDU 250
446636 AC002563 Hs 15767 citron (rtio-interxdng seππe/threonm 250
420795 AA323037 Hs 128645 sorting nexin 16 250
448582 AI538880 Hs 94812 ESTs 250
445459 AI478629 Hs 158465 likely ortholog of mouse putative IKK re 250
423909 AJ223183 Hs 135194 immunoglobulin superfamily, member 6 250
414315 Z24878 gb HSB65D052 STRATAGENE Human skeletal m 250
407568 AA740964 Hs 62699 ESTs 250
453911 AW503857 Hs 4007 Sarcolemmal-assxiated protein 250
431571 AW50O486 Hs 180610 splicing fxtor proline/glutamme nch ( 250
433843 AW021423 Hs 112819 ESTs 250
456254 T19844 gb B711 F Heart Homo sapiens cDNA clone B 250
403137 NA 250
425895 AI269484 Hs 161427 zinc finger protein 215 250
418612 AB037788 Hs 224961 cleavage and polyadenyladon spxific fa 250
TABLE 45B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank axession numbers
Pkey CAT Number Axessions
410784 1221005J AW803201 BE079700 BE062940 410902 1226078J AW809665AW810108AW809781 AW809844
411765 125700.1 H43346AA248302AA095182
413170 1351880.1 BE068819 BE068821 BE068825
413516 1374595 1 BE145907 BE145796 BE145803 BE145851 BE145923 BE145812 BE145809 BE145852 BE145856
414315 143512.T Z24878 AA494098 F13654AA494040AA143127 428858 296453.1 AA436760 AW237453 BE327496 N47347 N56967
430264 315008 1 AA470519 BE303010 BE302954 BE384120
431322 331543.1 AW970622AA503009AA502998AA502989AA502805T92188
434138 380572.1 AA625804 AW418787 AW074833 AI675642 AI393368
436411 419334.1 AW674352AA715374 Z25205 438159 45106.-2 Z83947
439929 48059.-1 S73205
451105 859083.1 AI761324AW880941 AW880937
452453 918300.1 AI902519AI902518 AI902516
454469 1213727.1 AW792775 BE0725O9 AW792958 454600 1226077.1 AW810001 AW810092AW810170AW809884AW809664AW810353AW810428AW810209 AW810429AW810154AW810168AW809786 AW810006
AW809672 AW809694 AW810552 AW810345 AW810432 AW809960
454821 1236365.1 AW833504 AW833751 AW833493AW833341
455309 1278153.1 AW894017AW893956AW894032 456254 16992461 T19844 T11755T11830T20136 T11957 R45834 R45828 R15595
TABLE 45C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers m this column are Genbank Identifier (Gl) numbers "Dunham et al " refers to the publication entitled "Thi sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted
Nt_posιdor i Indicates nudeodde positions of predicted exons
Pkey Ref Strand NLposition
401458 9187886 Plus 7648577597
401644 8576138 Plus 8265583959
401747 9789672 Minus 118595118816,119119-119244,119609-119761,120422-120990,130161-130381,130468-130593,131097-131258,131865 131932,132451-132575,133580-134011
402167 8571795 Plus 109122-110357
402299 6693370 Plus 23367-25175
402408 9796239 Minus 110326-110491
403137 9211494 Minus 92349-92572,92958-93084,93579-93712,93949-94072,94591-94748,95214-95337
403381 9438267 Minus 26009-26178
403422 9665041 Minus 151169-151561
403548 8081591 Minus 38760-39352
403637 8671936 Minus 142647-142771,145531-145762
403639 8671948 Plus 113234-113326,115185115287,119649-119786
403776 7770611 Minus 1414-1513,1624-1756
404253 9367202 Minus 5567556055
404440 7528051 Plus 80430-81581
404766 7882612 Minus 158681-158882,160838-160973
404996 6007890 Plus 37999-38145,38652-38998,39727-39872,40557-40674,42351-42450
405466 7767904 Minus 64498-64675
405770 2735037 Plus 61057-62075
405817 4071056 Plus 19914-20112,2565525810
406117 9142932 Plus 54304-54584
406182 5923650 Minus 2825528935
TABLE 46A ABOUT 1303 GENES UP-REGULATED IN STOMACH CANCER COMPARED TO NORMAL STOMACH
Table 46A lists about 1303 genes up-regulated in stomxh cancer ∞mpared to normal stomxh These were selxted as for Table 45A except using non-malignant stomxh spximens in determining the denominator value and the rado was equal to or greater than 50
Pkey Unique Eos probesel idendfier number
ExAxn Exemplar Axession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene tide
R1 Rado of tumor to normal body dssue
Pkey ExAccn UnigenelD Unigene Title R1
446619 AU076643 Hs 313 sxreted phosphoprotein 1 (osteopondπ, 8050
414152 NM 003248 Hs 75774 thrombospond 4 7052
421552 AF026692 Hs 105700 sxreted frizzled related protein 4 65 30
428698 AA852773 Hs 334838 KIAA1866 protein 61 90
428368 BE440042 Hs 83326 matπx metalloproteinase 3 (stromelysin 5060
409041 AB033025 Hs 50081 KIAA1199 protein 4450
452281 T93500 Hs 28792 Homo sapiens CDNA FU11041 fis, clone PL 41 10
452862 AW378065 Hs 8687 ESTs 33 50
427585 D31152 Hs 179729 collagen, type X, alpha 1 (Schmid etaph 32 10
424834 AK001432 Hs 153408 Homo sapiens cDNA FLJ10570 fis, clone NT 2690
428398 AI249368 Hs 98558 ESTs 2640
409757 NM.O01898 Hs 123114 cystadn SN 2548
403776 NA 24 90
427674 NM 003528 Hs 2178 H2B histone family, member Q 2380
419968 X04430 Hs 93913 interieukin 6 (interferon, beta 2) 23 10
427108 AB028976 Hs 173571 KIAA1053 protein 21 76
452401 NM 007115 Hs 29352 tumor nxrosis fxtor, alpha-induced pro 2070
400419 AF084545 NA 2040
415989 AI267700 Hs 317584 ESTs 1980
432101 AI918950 Hs 123642 EphA3 1970
418994 AA296520 Hs 89546 selxdn E (endothelial adhesion molxul 1900
452110 T47667 Hs 28005 Homo sapiens cDNA FU 11309 fis, clone PL 1840
412652 AI801777 Hs 6774 ESTs 1820
414430 AI346201 Hs 76118 ubiquitin carboxyl-terminal esterase L1 17 71
422168 AA586894 Hs 112408 S100 calcium-binding protein A7 (psonas 17 38
448988 Y09763 Hs 22785 gamma-aminobutync xid (GABA) A recepto 17 36
437446 AA788946 Hs 16869 ESTs, Moderately simila to CA1C RAT COL 1700
440594 AW445167 Hs 126036 ESTs 1700
430044 AA464510 Hs 152812 ESTs 17 00
426647 AA243464 Hs 294101 pre-B-cell leukemia transcnpdon fxtor 1690
414737 AI160386 Hs 125087 ESTs 16 50
427335 AA448542 Hs 251677 G andgen 7B 1630
423453 AW450737 Hs 128791 CGI-09 protein 15 50
414569 AF109298 Hs 118258 prostate cancer assxiated protein 1 15 40
401961 NA NA 1540
434551 BE387162 Hs 280858 ESTs, Highly similar to A35661 DNA excis 1540
432069 AW975868 Hs 294100 ESTs 1530
434699 AA643687 Hs 149425 Homo sapiens cDNA FLJ11980 fis clone HE 1530 409062 AL157488 Hs 50150 Homo sapiens mRNA, cDNA DKFZp564B182 (fr 1530
400289 X07820 Hs 2258 matπx metalloproteinase 10 (stromelysm 1520
415138 C18356 Hs 295944 dssue fxtor pathway inhibitor 2 1520
428820 AA436187 Hs 172631 integnn, alpha M (complement component 15 19
410763 AF279145 Hs 8966 hypothetical protein FU21776 15 10
438639 AI278360 Hs 31409 ESTs 15 10
458997 AW937420 Hs 69662 ESTs 1500
432731 R31178 Hs 287820 fibronxdn 1 1490
459247 N46243 Hs 110373 ESTs, Highly similar to T42626 sxreted 14 70
451099 R52795 Hs 25954 interieukin 13 rxeptor, alpha 2 1470
452242 R50956 Hs 159993 gycosyltransferase 1470
426427 M86699 Hs 169840 TTK protem kinase 1450
439924 AI985897 Hs 125293 ESTs 14 45
414869 AA157291 Hs 21479 ubinuclein 1 1440
411573 AB029000 Hs 70823 KIAA1077 protein 1440
418693 AI750878 Hs 87409 thrombospondin 1 1437
421823 N40850 Hs 28625 ESTs 14 30
423903 M57765 Hs 1721 interieukin 11 1420
419227 BE537383 Hs 89739 cholmergic receptor, nicodnic, beta po 14 10
447417 AW732858 Hs 143067 KIAA1602 protein 1396
416406 D86961 Hs 79299 lipoma HMGIC fusion partner-like 2 1390
446392 AF142419 Hs 15020 homolog of mouse quaking OKI (KH domain 1390
412863 AA121673 Hs 59757 zinc finger protein 281 1390
449509 AA001615 Hs 84561 ESTs 1380
440953 AI683036 Hs 124135 Homo sapiens cDNA FU13051 fis, clone NT 1380
432415 T16971 Hs 289014 ESTs, Weakly similar to A43932 mucin 2 p 1360
428769 AW207175 Hs 106771 ESTs 1360
416292 AA179233 Hs 42390 nasopharyngeal carcinoma susceptibility 1341
424580 AA446539 Hs 339024 ESTs, Weakly similar to A46010 X-dnked 1340
438459 T49300 Hs 35304 Homo sapiens cDNA FU13655 fis, clone PL 1330
431958 X63629 Hs 2877 cadheπn 3, type 1, P-cadheπn (plxenta 13 26
406972 M32053 gb Human H19 RNA gene, complete eds 13 19
432368 AW970244 Hs 162188 ESTs 13 16
424806 AA382523 Hs 105689 MSTP031 protein 1308
440351 AF030933 Hs 7179 RAD1 (S pombe) homolog 1298
437789 AI581344 Hs 127812 ESTs, Weakly simila to T17330 hypothed 1290
447164 AF026941 Hs 17518 Homo sapiens cιg5 mRNA, partial sequence 1280
417412 X16896 Hs 82112 interieukin 1 receptor, type I 1280
402363 NA NA 1278
444301 AKOO0136 Hs 10760 aspoπn (LRR class 1) 1276
416783 AA206186 Hs 79889 monxyte to mxrophage differendation-a 1260
435706 W31254 Hs 7045 GL004 protein 1250
414618 AI204600 Hs 96978 hypothedcal protein MGC10764 12 50
439737 AI751438 Hs 41271 Homo sapiens mRNA full length insert cDN 1249
405770 NA 1246
418678 NM 001327 Hs 167379 cancer/tesds antigen 1245
414132 AI801235 Hs 48480 ESTs 1240
410434 AF051152 Hs 63668 toll-like receptor 2 1230
451092 AI207256 Hs 13766 Homo sapiens mRNA for FU00074 protein, 1226
407891 AA486620 Hs 41135 endomucιn-2 1220
450506 NM.004460 Hs 418 fibroblast xdvadon protein, alpha 1201
411213 AA676939 Hs 69285 neuropilin 1 1200
436476 AA326108 Hs 33829 bHLH protein DEC2 1200
413582 AW295647 Hs 71331 hypothetical protein MGC5350 11 90
449318 AW236021 Hs 78531 Homo sapiens Similar to RIKEN cDNA 5730 11 90
401747 NA 11 88
409619 AK001015 Hs 55220 BCL2-assxιated athanogene 2 11 84
432596 AJ224741 Hs 278461 matnlin 3 11 80
400298 AA032279 Hs 61635 six transmembrane epithelial antigen of 11 73
425688 U48361 Hs 159223 NGFI-A binding protein 2 (ERG1 binding p 11 72
407938 AA905097 Hs 85050 phospholamban 11 70
419948 AB041035 Hs 93847 NADPH oxιd3Se 4 11 70
459645 AA074346 Hs 250715 ESTs 11 51
438462 AI624122 Hs 89578 general transcnpdon fxtor IIH, polype 11 50
434851 AA806164 Hs 116502 ESTs 11 50
418699 BE539639 Hs 173030 ESTs, Weakly similar to ALU8_HUMAN ALU S 11 47
413453 AA129640 Hs 128065 ESTs 11 40
442028 AI239437 Hs 48945 ESTs 11 0
428479 Y0O272 Hs 184572 cell division cycle 2, G1 to S and G2 to 11 39
453313 BE005771 Hs 153746 hypothedcal protein FU22490 11 20
421633 AF121860 Hs 106260 sorting nexin 10 11 20
410339 AI916499 Hs 298258 ESTs 11 20
448111 AA053486 Hs 20315 interferon-induced protein with tetratπ 11 15
453857 AL080235 Hs 35861 DKFZP586E1621 protein 11 15
430217 N47863 Hs 336901 nbosomal protein S24 11 10
452823 AB012124 Hs 30696 transcπption fxtor-like 5 (basic helix 11 10
416530 U62801 Hs 79361 kallikrein 6 (neurosin, zyme) 11 06
416854 H40164 Hs 80296 Purkmie cell protein 4 1090
447072 D61594 Hs 17279 tyrosylprotem sulfotransferase 1 1090
424882 AI379461 Hs 153636 far upstream element (FUSE) binding prot 1080
448693 AW004854 Hs 228320 hypothetical protein FU23537 1080
408750 BE294069 Hs 93581 hypothedcal protein FU10512 1080
450221 AA328102 Hs 24641 cytoskeleton assxiated protein 2 1080 436411 AW674352 gb ba63c07 y1 NIH.MGCJ2 Homo sapiens cD 1080
441693 AA384673 Hs 7943 RPB5medιatιng protein 1080
414922 D00723 Hs 77631 glycine cleavage system protein H (am o 1080
441801 AW242799 Hs 86366 ESTs 1080
417173 U61397 Hs 81424 ubiquidn-like 1 (sentπn) 1080
415727 BE501389 Hs 20848 ESTs, Weakly simila to APAF.HUMAN APOPT 1080
414142 AW368397 Hs 150042 Homo sapiens cDNA FU14438 fis, clone HE 1080
421650 AA781795 Hs 122587 ESTs 1080
439999 AA115811 Hs 6838 ras homolog gene family, member E 1070
421814 L12350 Hs 108623 thrombospondin 2 1069
415060 AJ223810 Hs 43213 ESTs, Weakly similar to IEFS.HUMAN TRANS 1067
421462 AF016495 Hs 104624 aquapoπn 9 1066
410444 W73484 gb zd54e04 s1 Soares_fetal.heat_NbHH19W 1061
409743 N48721 Hs 183506 hypothedcal protein FLJ1421~3 1060
446142 AI754693 Hs 145968 ESTs 1060
444114 T58003 Hs 10323 Homo sapiens mRNA from chromosome 5q31-3 1060
423020 AA383092 Hs 1608 replication protein A3 (14kO) 1055
453891 AB037751 Hs 36353 Homo sapiens mRNA full length insert cDN 1050
417352 AA195919 gb zp95h09 r1 Stratagene muscle 937209 H 1046
417866 AW067903 Hs 82772 collagen, type XI, alpha 1 1042
427718 AI798680 Hs 25933 ESTs 1040
412589 R28660 Hs 24305 ESTs 1040
433332 AI367347 Hs 44898 Homo sapiens clone TCCCTA00151 mRNA sequ 1040
424717 H03754 Hs 152213 wingless-type MMTV integradon site fami 1030
450434 AA166950 Hs 195870 hypothedcal protein FU14991 1030
409044 AI129586 Hs 33033 hypothetical protein FU14623 1030
423600 AI633559 Hs 310359 ESTs 1030
433819 AW511097 Hs 112765 ESTs 1018
415076 NM 000857 Hs 77890 guanylate cyclase 1 , soluble, beta 3 10 10
410503 AW975746 Hs 188662 KIAA1702 protein 10 10
433800 AI034361 Hs 135150 lung type-l cell membraπe-assxiated gly 10 10
429357 AA779725 Hs 164589 ESTs 1000
452838 U65011 Hs 30743 preferentially expressed andgen in mela 1000
414117 W88559 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbx 1000
416198 H27332 Hs 99598 hypothedcal protein MGC5338 1000
413918 AW015898 Hs 71245 ESTs 1000
400570 NA NA 1000
439333 AW384710 Hs 125258 Homo sapiens cDNA FU13795 (is, clone TH 997
444863 AW384082 Hs 104879 senne (or cysteine) proteinase inhibito 993
450101 AV649989 Hs 24385 Human hbc647 mRNA sequence 990
434352 AF129505 Hs 86492 small muscle protein, X-linked 990
453160 AI263307 Hs 239884 H2B histone family member L 990
433929 AI375499 Hs 27379 ESTs 989
413273 U75679 Hs 75257 stem-loop (histone) binding protein 981
437536 X91221 Hs 144465 ESTs 9 80
441350 AB020690 Hs 7782 paraneoplasdc andgen MA2 980
452291 AF015592 Hs 28853 CDC7 (cell division cycle 7, S cerevisi 980
438913 AI380429 Hs 172445 ESTs 980
417849 AW291587 Hs 82733 nidogen 2 9 78
424086 AI351010 Hs 102267 lysyl oxidase 9 72
428186 AW504300 Hs 295605 mannosidase, alpha, class 2A, member 2 970
414422 AA147224 Hs 337232 ESTs 970
419197 N48921 Hs 27441 KIAA1615 protein 9 70
427660 AI741320 Hs 114121 Homo sapiens cDNA FU23228 fis, clone C 970
449347 AV649748 Hs 295901 KIAA0493 protein 970
409643 AW450866 Hs 257359 ESTs 970
436209 AW850417 Hs 254020 ESTs Moderately similar to unnamed prot 970
439608 AW864696 Hs 301732 hypothedcal protein MGC5306 960
430290 AI734110 Hs 136355 ESTs 960
447124 AW976438 Hs 17428 RBPMike protein 960
413879 AA132961 Hs 212533 Homo sapiens cONA FU22572 fis, clone H 960
408101 AW968504 Hs 123073 CDC2-related protein kinase 7 958
418067 AH 27958 Hs 83393 cystadn E/M 954
424001 W67883 Hs 137476 paternally expressed 10 950
443037 AW500305 Hs 299166 syntaxin 7 950
428493 AK001745 Hs 184628 hypothedcal protein FU 10883 950
420170 U43374 Hs 95631 Human normal keradnxyte mRNA 950
409269 AA576953 Hs 22972 hypothetical protein FU 13352 950
443162 T49951 Hs 9029 DKFZP434G032 protein 945
444381 BE387335 Hs 283713 ESTs, Weakly similar to S64054 hypothed 943
424026 AI798295 Hs 137576 πbosomal protein L34 pseudogene 1 940
440052 AI633744 Hs 195648 ESTs. Weakly simila to I38022 hypothed 940
403137 NA 937
418051 AW192535 Hs 19479 ESTs 9 35
418701 AA814948 Hs 96343 ESTs. Weakly similar to ALUC_HUMAN "" 930
430291 AV660345 Hs 238126 CGI-49 protein 930
426137 AL040683 Hs 167031 DKFZP566D133 protein 930
400195 NA NA 930
411529 AA430348 Hs 317596 Homo sapiens cDNA FU12927 fis, clone NT 920
423936 U77629 Hs 135639 xhxte-scute complex (Drosophila) homol 920
414259 W44633 Hs 301296 Homo sapiens cDNA FU23131 fis, clone L 920
416661 AA634543 Hs 79440 IGF-II mRNA-bindmg protem 3 920
405543 NA NA 920 420900 AL045633 Hs 44269 ESTs 9 11
450757 BE081050 Hs 31570 ESTs Weakly similar to KIAA1324 protein 910
410929 H47233 Hs 30643 ESTs 9 10
427319 AW631495 Hs 27135 B-cell receptor-assxiated protein BAP29 9 10
443745 AB039670 Hs 9728 ALEX1 protein 910
436574 AW293527 Hs 126465 ESTs 910
407192 AA609200 gb af12e02 s1 Soares_testιs_NHT Homo sap 908
426075 AW513691 Hs 270149 ESTs, Weakly similar to 2109260A B cell 907
408778 AI500519 Hs 63382 hypothetical protein PR02714 903
434542 AA769310 Hs 61260 hypothedcal protein FU13164 900
404440 NA 900
407168 R45175 Hs 117183 ESTs 900
451678 AA374181 Hs 26799 OKFZP564D0764 protein 900
431946 AI018336 Hs 131730 ESTs 892
408875 NM 015434 Hs 48604 DKFZP434B168 protein 890
409928 AL137163 Hs 57549 hypothedcal protein dJ473B4 890
430294 AI538226 Hs 32976 guanine nudeodde binding protein 4 889
445029 AF196481 Hs 12256 midlme 2 886
442717 R88362 Hs 180591 ESTs, Weakly similar to T23976 hypothed 880
409089 NM 014781 Hs 50421 KIAA0203 gene product 880
419261 X07876 Hs 89791 wingless-type MMTV tegradon site fami 880
416190 N54000 gb yy99d02 r1 Soares.muldple.sclerosis. 880
444783 AK001468 Hs 62180 anillin (Drosophila Scraps homolog), xt 877
416440 AI823912 Hs 79335 Homo sapiens, Similar to SWI/SNF related 876
421262 AA286746 Hs 9343 Homo sapiens cDNA FU 14265 fis, clone PL 870
441031 AI110684 HS 7645 fibπnogen, B beta polypepdde 870
452234 AW084176 Hs 223296 ESTs, Weakly similar to I38022 hypothed 870
452822 X85689 Hs 288617 hypothedcal protein FU22621 870
430462 AI584156 Hs 105640 Homo sapiens, clone IMAGE 4139775, mRNA, 865
426457 AW894667 Hs 169965 chimeπn (chimaenn) 1 865
412054 W87482 Hs 302209 ESTs 864
450236 AW162998 Hs 24684 KIAA1376 protein 863
418782 AI792648 Hs 14665 ESTs 860
452631 AI188658 Hs 87496 ESTs 860
425268 AI807883 Hs 180059 Homo sapiens cDNA FU20653 fis, clone KA 860
432014 H66741 Hs 38540 ESTs, Weakly similar to ALU4.HUMAN ALU S 860
440270 NM.015986 Hs 7120 cytokine receptor-like molxule 9 860
414784 NM 000344 Hs 288986 survival of motor neuron 1, telomenc 860
426809 BE313114 Hs 29706 ESTs 860
419704 AA429104 Hs 45057 ESTs 860
452909 NM 015368 Hs 30985 pannexin 1 860
432639 AW973785 gb EST385886 MAGE resequences, MAGM Homo 860
430418 R98852 Hs 36029 heart and neural crest denvadves expre 8 58
450480 X82125 Hs 25040 zinc finger protein 239 8 58
444984 H15474 Hs 132898 fatty xid desaturase 1 858
419086 NM 000216 Hs 89591 Kallmann syndrome 1 sequence 857
430518 AW363687 Hs 82916 chaperonin containing TCP1, subunit 6A ( 850
424735 U31875 Hs 272499 short-chain alcohol dehydrogenase family 8 50
414061 NM 000699 Hs 300280 amylase, alpha 2A, pancreatic 8 50
407894 AJ278313 Hs 41143 phosphomositide-spxific phospholipase 850
441079 AW150697 Hs 107418 ESTs 850
419354 M62839 Hs 1252 apolipoprotein H (beta-2-glycoprotem I) 850
418618 U66097 Hs 86724 GTP cyclohydrolase 1 (dopa-responsive dy 850
416565 AW000960 Hs 44970 endoplasmic reticulum resident protein 5 850
441540 C01367 Hs 127128 ESTs 850
416434 AW163045 Hs 79334 nuclear fxtor, interieukin 3 regulated 850
417801 AA417383 Hs 82582 integnn, beta-like 1 (with EGF-like rep 850
426855 AL117427 Hs 172778 Homo sapiens mRNA, cDNA OKFZp566P013 (fr 848
436515 AJ278111 Hs 195292 putadve tumor andgen 843
416315 AA179483 Hs 73605 ESTs 842
408432 AW195262 gb xn67b05 x1 NCI_CGAP_CML1 Homo sapiens 840
410094 BE147897 Hs 58593 general transcnpdon fxtor IIF, polype 840
419198 AA234938 Hs 87384 ESTs 836
448920 AW408009 Hs 22580 alkylglycerone phosphate synthase 8 36
410305 AF030409 Hs 62185 solute earner family 9 (sodium/hydrogen 8 31
408687 AL110280 Hs 301152 Homo sapiens mRNA, cDNA DKFZp434F053 (fr 830
427707 NM 005578 Hs 180398 LIM domain-containing preferred translx 830
459060 H89244 Hs 303627 heterogeneous nuclear nbonucleoprotein 830
451957 AI796320 Hs 10299 Homo sapiens cDNA FU13545 fis, clone PL 830
443977 AL120986 Hs 150627 ESTs, Weakly similar to I38022 hypothed 830
457997 AA806616 Hs 209523 ESTs 830
451934 AI540842 Hs 61082 ESTs 830
404335 NA 830
445073 AW291389 Hs 13056 hypothetical protein FU 13920 830
431566 AF176012 Hs 260720 J domain containing protein 1 829
446307 T50083 Hs 9094 ESTs 8 28
423928 AA332680 gb EST36768 Embryo, 8 week I Homo sapien 8 26
436420 AA443966 Hs 31595 ESTs 825
426110 NM 002913 Hs 166563 replication fxtor C (xdvator 1) 1 (14 825
442988 AI026130 Hs 131683 ESTs 8 25
402408 NA NA 8 24
438707 L08239 Hs 5326 ammo xid system N transporter 2, porcu 8 23
425770 NM 014363 Hs 159492 spastic ataxia of Chartevoix-Saguenay (s 822 448704 AW080932 Hs 249247 heterogeneous nuclear protein simila to 821
452682 AA456193 Hs 9071 progesterone membrane binding protein 820
411984 NM 005419 Hs 72988 signal transducer and xdvator of trans 820
420018 U56387 Hs 94376 proprotein convertase subdlisin/kexm t 820
437048 AA743240 Hs 91582 ESTs 8 20
424653 AW977534 Hs 151469 cateium/calmodulin-depeπdent senne prot 820
447066 BE167667 Hs 32163 ESTs 820
425932 M81650 Hs 1968 semenogelm I 820
431819 AA515995 Hs 152334 ESTs 820
431810 X67155 Hs 270845 kinesm-like 5 (mitodc kinesm-like pro 820
459702 AI204995 gb an03c03 x1 Stratagene schizo bran S1 820
406687 M31126 Hs 272620 pregnancy spxific beta-1-glycoproteιn 9 8 18
413109 AW389845 Hs 110855 ESTs 8 17
424720 M89907 Hs 152292 SWI/SNF related, matπx associated, xd 816
424335 AW021508 Hs 28170 ESTs 8 10
453096 AW294631 Hs 11325 ESTs 810
427738 NM 000318 Hs 180612 peroxisomal membrane protein 3 (35kD, Ze 8 10
457796 AA913389 Hs 126691 ESTs 8 10
429340 N35938 Hs 199429 Homo sapiens mRNA, cDNA DKFZp434M2216 (f 810
445165 AV652831 gb AV652831 GLC Homo sapiens cDNA clone 808
418046 W49670 Hs 56044 ESTs 806
426269 H15302 Hs 168950 Homo sapiens mRNA, cDNA DKFZp566A1046 (f 804
439451 AF086270 Hs 278554 heterxhromadn-like protein 1 802
419559 Y07828 Hs 91096 ππg finger protein 802
409268 AA625304 Hs 188554 ESTs 800
447207 AA442233 Hs 17731 hypothedcal protein FU12892 800
446977 AW863613 Hs 156798 ESTs 800
424565 AW102723 Hs 75295 guanylate cydase 1, soluble, alpha 3 800
407013 U35637 gb Human nebulm mRNA, partial eds 799
414523 AU076633 Hs 76353 senne (or cysteine) proteinase inhibito 798
440637 AW900115 Hs 7309 Homo sapiens clone 23741 mRNA sequence 796
417076 AW973454 Hs 238442 ESTs, Moderately similar to ALU7_HUMAN A 795
425921 NM 007231 Hs 162211 solute earner family 6 (neurotraπsmitte 794
415585 R59946 Hs 184852 KIAA1553 protein 792
453331 AI240665 Hs 8895 ESTs 792
445527 W39694 Hs 83286 ESTs, Weakly simila to S14747 sphingomy 790
417318 AW953937 Hs 12891 ESTs 790
429393 AA383024 Hs 201603 Homo sapiens mRNA, cDNA DKFZp434D0917 (f 790
444769 AI191650 Hs 221436 ESTs 790
444272 AI138596 Hs 154619 ESTs 790
425264 AA353953 Hs 20369 ESTs, Weakly similar to gonadotropin md 7 90
412642 BE244598 Hs 809 hepatocyte growth fxtor (hepapoiedn A, 790
453765 BE279901 Hs 35091 hypothedcal protein FU10775 790
421558 AB011125 Hs 105749 KIAA0553 protein 790
446444 AI743737 Hs 24370 ESTs 790
420000 AB036063 Hs 94262 p53-ιnducιble nbonucleodde reductase s 786
437237 BE513073 gb 601171435F1 NIH MGC 15 Homo sapiens c 786
409582 R27430 Hs 271565 ESTs 784
419235 AW470411 Hs 288433 neurotπmin 783
439620 AA838727 Hs 124405 ESTs Weakly similar to A46010 X-lmked 7 82
441690 R81733 Hs 33106 ESTs 780
417735 AA188175 Hs 82506 KIAA1254 protein 780
441795 N58115 Hs 21137 AD024 protein 780
442992 AI914699 Hs 13297 ESTs 780
422554 AA312219 Hs 296338 ESTs 780
423123 NM 012247 Hs 124027 SELENOPHOSPHATE SYNTHETASE . Human selen 780
428627 BE0O2993 Hs 187660 putative Rab5 GDP/GTP exchange fxtor ho 780
429228 AI553633 Hs 337139 ESTs 780
429399 AA452244 Hs 16727 ESTs 780
436396 AI683487 Hs 152213 wingless type MMTV integration site fami 777
455510 AA422029 Hs 143640 ESTs, Weakly similar to hyperpolanzado 776
429396 AW954598 Hs 201626 Homo sapiens clone 25015 mRNA sequence 7 76
453439 AI572438 Hs 32976 guanine nucleotide binding protein 4 7 75
410561 BE540255 Hs 6994 Homo sapiens cDNA FU22044 fis, ctone H 771
442875 BE623003 Hs 23625 Homo sapiens clone TCCCTA00142 mRNA sequ 7 71
428655 H05769 Hs 188757 Homo sapiens, ctone MGC 5564, mRNA, comp 770
413374 NM.001034 Hs 75319 nbonucleodde reductase M2 polypeptide 7 70
404996 NA 770
418947 W52990 Hs 22860 ESTs 7 70
427401 U20582 Hs 2149 xdn like protein 770
410748 BE383816 Hs 12532 chromosome 1 open reading frame 21 7 70
426262 AI792141 Hs 196270 folate transporter/carrier 7 70
446955 AW613138 Hs 156747 ESTs 7 70
449199 AI990122 Hs 196988 ESTs 770
443212 AW269515 Hs 102500 hypothetical protein FU20481 7 70
446155 AI553695 Hs 159422 Homo sapiens cDNA FLJ13997 fis, ctone Y7 770
427164 AB037721 Hs 173871 KIAA1300 protein 7 70
452627 AI122843 Hs 184319 ESTs, Weakly similar to KIAA1006 protein 7 70
452588 AA889120 Hs 110637 homeo box A10 770
451838 AW005866 Hs 193969 ESTs 7 67
422956 BE545072 Hs 122579 hypothedcal protein FU10461 766
451227 R84429 Hs 151944 ESTs, Weakly similar to high-πsk human 7 66
450701 H39960 Hs 288467 Homo sapiens cDNA FLJ12280 fis, clone MA 7 65 432695 D63480 Hs 278634 KIAA0146 protein 763
447476 BE293466 Hs 20880 ESTs, Weakly similar to 138022 hypotheti 760
447289 AW247017 Hs 36978 melanoma antigen, family A, 3 760
447505 AL049266 Hs 18724 Homo sapiens mRNA, cDNA DKFZp564F093 (fr 760
423065 R96158 Hs 267130 Homo sapiens, clone MGC 5406, mRNA comp 760
437396 BE140396 Hs 21621 hypothedcal protein DKFZp762O076 760
450628 AW382884 Hs 204715 ESTs 760
418995 H39599 Hs 294008 ESTs 760
416402 NM.O00715 Hs 1012 complement component 4-bιndιng protein, 760
405545 NA 760
440866 AI703103 Hs 271360 hypothedcal protein MGC16275 760
421281 AI299139 Hs 17517 ESTs 760
424634 NM 003613 Hs 151407 cartilage intermediate layer protein, nu 760
421041 N36914 Hs 14691 ESTs, Moderately similar to I38022 hypot 760
453311 AW104911 Hs 126707 hypothedcal protein FU11457 754
453060 AW294092 Hs 21594 hypothedcal protein MGC15754 750
417655 AA780791 Hs 14014 hypothedcal protein FU14813 750
417531 NM 003157 Hs 1087 seπne/threonine kinase 2 750
444099 D87432 Hs 10315 solute earner family 7 (cationic ammo 750
407853 AA336797 Hs 40499 dickkopf (Xenopus laevis) homolog 1 750
408920 AL120071 Hs 48998 fibroπxdπ leucine nch transmembrane p 750
447806 W03616 Hs 10432 ESTs, Weakly simila to 138022 hypothed 748
424748 AA346257 Hs 134933 ESTs 748
421089 AB037771 Hs 101799 KIAA1350 protein 746
444856 AI888057 Hs 12097 ESTs 742
447425 AI963747 Hs 18573 xylphosphatase 1, erythrocyte (common) 741
418450 R84397 Hs 193651 ESTs, Weakly similar to alternadvely sp 740
434539 AW748078 Hs 214410 ESTs Weakly similar to MUC2 HUMAN MUCIN 740
437036 AI571514 Hs 133022 ESTs 740
414680 AA743331 Hs 272572 hemoglobin, alpha 2 740
451815 AW974911 Hs 184793 Homo sapiens cDNA FU21880 fis, clone H 740
433577 AW007080 Hs 8817 ESTs 740
453652 AW009640 Hs 28368 ESTs, Moderately simila to S65657 alpha 740
422665 AJ011812 Hs 119018 transcnpdon fxtor NRF 740
424188 AW954552 Hs 142634 zinc finger protein 740
407300 AA102616 gb zn43e07 s1 Stratagene HeLa cell s393 740
431494 AA991355 Hs 298312 hypothedcal protein DKFZp434A1315 740
452958 AA883929 Hs 40527 ESTs 740
418763 AK000219 Hs 88367 hypothetical protein FU20212 740
428279 AA425310 Hs 155766 ESTs Weakly simila to A47582 B-cell gr 740
449670 F07693 Hs 23869 Homo sapiens mRNA, cDNA DKFZp434K2172 (f 740
449601 AA461509 Hs 293565 ESTs Weakly similar to putative p150 (H 740
438490 AW593272 Hs 301299 ESTs 740
410044 BE566742 Hs 58169 highly expressed in cancer, nch in leuc 740
429509 AW614420 Hs 204354 ras homolog gene family, member B 738
433393 AF038564 Hs 98074 itchy (mouse homolog) E3 ubiquitin prote 738
434096 AW662958 Hs 75825 pleio orphic adenoma gene-like 1 737
425773 N21279 Hs 237749 ESTs 736
422755 T25365 Hs 119687 RAN binding protein 8 736
410566 AA373210 Hs 43047 Homo sapiens cDNA FU13585 fis, clone PL 735
412851 AI826502 Hs 106149 ESTs 735
418661 NM 001949 Hs 1189 E2F transcnpdon fxtor 3 735
436246 AW450963 Hs 119991 ESTs 734
433159 AB035898 Hs 150587 kinesm-like protein 2 733
444781 NM 014400 Hs 11950 GPI-anchored metastasis-assxiated prote 7 32
453878 AW964440 Hs 19025 DC32 7 31
414696 AF002020 Hs 76918 Niemann-Pick disease, type C1 731
402250 AV655272 Hs 20252 novel Ras family protein 7 31
439039 AI656707 Hs 48713 ESTs 730
417976 BE565892 Hs 83077 interieukin 18 (interferon-gamma-inducin 730
419436 AA991639 Hs 242413 hypothetical protein DKFZp434K1421 730
417006 AW673606 Hs 80758 aspartyl-IRNA synthetase 730
425420 BE536911 Hs 234545 hypothetical protein NUF2R 730
425889 M57414 Hs 161305 txhykmiπ receptor 2 729
442969 AI025499 Hs 132238 ESTs 726
446360 N42553 Hs 267914 homolog of mouse transient rxeptor pote 7 25
438022 AW517524 Hs 135201 NOD2 protein 725
407183 AA358015 gb EST66864 Fetal lung III Homo sapiens 7 24
429882 AA278898 Hs 225979 hypothetical protein similar to small G 7 24
420120 AL049610 Hs 95243 tranxπption elongadon fxtor A (Sll)- 7 22
400212 NA NA 720
431812 AA515902 Hs 130650 ESTs 720
419481 AI879195 Hs 90606 15 kDa selenoproteιn 720
447078 AW885727 Hs 301570 ESTs 720
413200 AA127395 Hs 222414 ESTs 720
411750 BE562298 Hs 71827 KIAA0112 protem, homolog of yeast πbos 720
439901 N73885 Hs 124169 ESTs 7 20
411815 AA156679 Hs 125790 leucine-nch repeat-containing 2 720
459279 AW814996 gb MR1-ST0206-1704O0-024-h09 ST0206 Homo 720
445263 H57646 Hs 42586 KIAA1560 protein 7 20
413801 M62246 Hs 35406 ESTs. Highly simila to unnamed protein 720
418407 AL044818 Hs 84928 nuclear transcnpdon fxtor Y, beta 720
452221 C21322 Hs 288057 hypothedcal protein FU22242 720 425202 AW962282 Hs 152049 ESTs, Weakly similar to I38022 hypothed 7 20
403764 NA 720
416896 AI752862 Hs 5638 KIAA1572 protein 7 20
416636 N32536 Hs 42645 ESTs 7 20
428071 AF212848 Hs 182339 ets homologous fxtor 720
450142 AW207469 Hs 24485 chondroidn sulfate proteoglycan 6 (bama 7 18
451017 BE391847 Hs 181173 hypothedcal protein MGC10771 7 17
409759 N40285 Hs 81182 histamme N-methyltransferase 7 16
452448 AW182440 Hs 61389 ESTs, Weakly similar to unnamed protein 16
427951 AI826125 Hs 43546 ESTs 7 16
407939 W05608 Hs 312679 ESTs, Weakly simila to A49019 dynein he 7 15
419457 AA243146 Hs 209334 ESTs, Moderately similar to S23A.HUMAN P 7 12
411769 AI694575 Hs 27207 KIAA0982 protein 7 11
430355 NM 006219 Hs 239818 phosphoιnosιdde-3-kιnase, catalydc, be 710
419511 AA429750 Hs 75113 general transcnpdon fxtor IIIA 7 10
409032 AW301807 Hs 297260 ESTs 7 10
424539 L02911 Hs 150402 xdvin A receptor, type I 7 10
439221 AA737106 Hs 32250 ESTs, Moderately similar to I78885 senn 710
430719 AA488988 Hs 293796 ESTs 710
408020 AA127940 Hs 62781 ESTs 7 10
420218 AW958037 Hs 286 nbosomal protein L4 7 10
443487 AI073491 Hs 269887 ESTs, Highly similar to KPBB.HUMAN PHOSP 7 10
414865 AA157155 Hs 274414 hypothedcal protein FU14457 7 10
428724 AL390128 Hs 191268 KIAA1530 protein 710
413293 AL047483 Hs 302498 GTP-binding protein homologous to Sa∞ha 710
419126 AI810144 Hs 135276 ESTs 709
437044 AL035864 Hs 69517 cDNA for differentially expressed C016 g 709
433730 AK002135 Hs 3542 hypothedcal protein FU11273 707
417381 AF164142 Hs 82042 solute earner family 23 (nucl∞base tra 707
457019 AA421844 Hs 12830 hypothedcal protein 707
409697 AB018348 Hs 55947 KIAA0805 protein 706
400977 NA NA 706
436668 AA831857 Hs 209071 ESTs 703
451684 AF216751 Hs 26813 CDA14 703
404029 NA 702
448719 AA033627 Hs 21858 tπnucleodde repeat contanmg 3 702
445577 N40696 Hs 137064 cytoplasmic polyadenylation element bind 700
419647 AA348947 Hs 91816 hypothedcal protein 700
442075 AW136928 gb UI-H-BH-adp-d-08-O-UI s1 NCI CGAP_Su 700
429598 AA811257 Hs 269710 ESTs 700
450832 AW970602 Hs 105421 ESTs 700
421389 AA531291 Hs 101064 Homo sapiens cDNA FU12777 fis, clone NT 700
453931 AL121278 Hs 25144 ESTs 700
432343 NM 002960 Hs 2961 S100 calcium-binding protein A3 700
452979 AW167599 Hs 232282 ESTs 700
431696 AA259068 Hs 267819 protein phosphatase 1 , regulatory (inhib 700
413583 AL120806 Hs 5888 ESTs 700
436758 AW977167 Hs 155272 ESTs 700
455944 BE160643 gb PM1 HT0422-291299-002403 HT0422 Homo 698
430302 AL137502 Hs 238679 Rag D protein 696
437613 R19892 Hs 10267 MIL1 protein 696
440524 R71264 Hs 16798 ESTs 695
451047 AB022317 Hs 25887 sema domain, immunoglobulin domain (Ig) 693
450377 AB033091 Hs 74313 KIAA1265 protein 693
457396 Z20964 Hs 323817 DKFZP547E1010 protein 693
417393 R10484 Hs 82071 Cbp/p300-ιnterxdπg transxdvator, wit 692
414417 BE299433 Hs 68533 KIAA1679 protem 692
412246 AI160873 Hs 69233 zinc finger protein 690
411003 AA181018 Hs 13056 hypothedcal protein FU13920 690
413833 Z15005 Hs 75573 centromere protein E (312kD) 690
405696 NA NA 690
431689 AA305688 Hs 267695 UDP-Gal betaGlcNAc beta 1,3-galxtosyltr 690
414429 R51494 Hs 71818 ESTs 690
424641 ABO01106 Hs 151413 glia maturadon fxtor, beta 690
418895 AA894638 Hs 14600 ESTs 690
445900 AF070526 Hs 13429 Homo sapiens clone 24787 mRNA sequence 690
446006 NM 004403 Hs 13530 deafness, autosomal dominant 5 690
432038 AA524746 Hs 162110 ESTs 687
446610 AV659433 Hs 282984 ESTs, Weakly similar to 138022 hypotheti 686
451286 AW139789 Hs 16370 Homo sapiens cDNA FLJ11652 fis, clone HE 686
408915 NM 016651 Hs 48950 heptacellular carcinoma novel gene 3 pro 685
418934 T83845 Hs 191116 ESTs 682
435143 R12375 Hs 194600 ESTs 682
442660 AW138174 Hs 130651 ESTs 682
432729 AKO00292 Hs 278732 hypothedcal protein FU20285 681
435990 AI015862 Hs 131793 ESTs 680
449062 AJ272268 Hs 22958 calcium channel, voltage-dependent alph 680
453688 AW381270 Hs 194110 hypothedcal protein PRO2730 680
421476 AW953805 Hs 21887 ESTs 680
430510 AW162916 Hs 241576 hypothetical protein PR02577 680
409045 AA635062 Hs 50094 Homo sapiens mRNA, cDNA DKFZp434O0515 (f 680
410298 AI693821 Hs 182185 ESTs 680
420560 AW207748 Hs 59115 ESTs 680 427752 AA470687 Hs 104772 ESTs 680
414080 AA135257 Hs 47783 B aggressive lymphoma gene 680
422420 U03398 Hs 1524 tumor nxrosis fxtor (ligand) superfami 680
416913 AW934714 gb C1-DT0001 031299-011-311 DT0001 Homo 680
426890 AA393167 Hs 1294 ESTs 680
411773 NM 006799 Hs 72026 protease, senne, 21 (tesdsm) 680
413328 Y15~723 Hs 75295 guanylate cyclase 1, soluble, alpha 3 679
437619 AW351491 Hs 334853 hypothetical protein FU23544 679
434267 AI206589 Hs 116243 ESTs 679
419358 T78763 Hs 90063 neurocalcin delta 679
435854 AJ278120 Hs 4996 putative ankynn-repeat contanmg prote 678
424925 NM 002432 Hs 153837 myeloid cell nuclea differentiation ant 677
443184 AI638728 Hs 131973 ESTs 677
444484 AK002126 Hs 11260 hypothedcal protein FU11264 677
429483 AA974832 Hs 128708 ESTs 676
425605 BE54430O Hs 7076 KIAA1705 protein 676
425045 AW953186 Hs 92400 ESTs 676
438776 AW245243 Hs 334368 hypothedcal protein MGC11257 675
458174 AA781530 Hs 127236 hypothetical protein FLJ 12879 674
445129 R39878 Hs 21394 ESTs 674
435532 AW291488 Hs 117305 Homo sapiens, ctone IMAGE 3682908, mRNA 673
444442 AI149234 Hs 298423 ESTs, Moderately similar to I54374 gene 673
431240 AA496790 Hs 179481 ESTs 672
422109 S73265 Hs 1473 gastπn releasing peptide 670
416655 AW968613 Hs 79428 BCL2/adenovιrus E1B 19kD-ιnterxdng pro 670
423811 AW299598 Hs 50895 hom∞ box C4 670
443695 AW204099 Hs 337720 ESTs, Weakly similar to AF126780 1 redn 670
420686 AI950339 Hs 40782 ESTs 670
419574 AK001989 Hs 91165 hypothedcal protein 670
418269 AA806113 Hs 189025 ESTs 670
434164 AW207019 Hs 148135 seπne/threonine kinase 33 670
408660 AA525775 Hs 292523 ESTs Moderately similar to PC4259 fern 670
453370 AI470523 Hs 139336 ATP-bindmg cassette, sub-family C (CFTR 670
409506 NM 006153 Hs 54589 NCK adaptor protein 1 670
454029 W05150 Hs 37034 homx box A5 6 70
413365 AW205188 Hs 124304 Homo sapiens cDNA FU 14635 fis, clone NT 670
447247 AW369351 Hs 287955 Homo sapiens cONA FU 13090 fis, clone NT 670
426566 AF131836 Hs 170453 fropomodulin 6 70
446261 AA313893 Hs 306219 hypothedcal protein FU12615 similar to 670
408547 AA574291 Hs 57837 ESTs 670
430458 AA479300 Hs 225706 ESTs, Weakly similar to I38022 hypothed 6 70
413627 BE182082 Hs 246973 ESTs 670
410498 AA355749 gb EST64459 Jurkat T-cells VI Homo sapie 670
434015 AA844518 Hs 300876 hypothedcal protein FU13386 6 70
453691 H12235 Hs 226505 ESTs 668
415068 Z19448 Hs 131887 ESTs Weakly similar to T24396 hypotheti 668
415885 D79983 Hs 78894 KIAA0161 gene product 6 68
405529 AW410458 Hs 5258 chromosome 11 open reading frame2 668
438242 AW241910 Hs 122254 ESTs, Weakly similar to JX0369 collagen 668
442643 U82756 Hs 8551 PRP4/STK WD splicing fxtor 667
424802 X79201 Hs 153221 synovial sarcoma, translxated to X chro 667
415007 BE244332 Hs 77770 adaptor-related protein complex 3, mu 2 667
458714 R20916 Hs 202501 ESTs 6 66
414591 AI888490 Hs 55902 ESTs, Weakly similar to ALU8_HUMAN ALU S 665
433260 AB040966 Hs 83575 KIAA1533 protein 6 65
400268 NA NA 663
453180 N46243 Hs 110373 ESTs, Highly similar to T42626 sxreted 662
403973 NA NA 660
436862 AI821940 Hs 264622 ESTs, Moderately similar to ALU8.HUMAN A 660
428046 AW812795 Hs 155381 ESTs, Moderately similar to I38022 hypot 660
453387 AI990741 Hs 252809 ESTs 660
424084 AI940675 Hs 20914 hypothetical protem FLJ23056 660
418444 AI902899 Hs 85155 butyrate response fxtor 1 (EGF-response 660
448172 N75276 Hs 135904 ESTs 660
409571 AA504249 Hs 187585 ESTs 660
423025 AA831267 Hs 12244 hypothedcal protein FU 20097 660
430701 AI760833 Hs 293971 ESTs 660
450373 AI915790 Hs 337282 ESTs 6 60
419384 AA490866 Hs 39429 ESTs 660
429828 AB019494 Hs 225767 IDN3 protein 660
441761 AI222880 gbqp40c06x1 NCI_CGAP_Co8 Homo sapiens 660
411048 AK001742 Hs 67991 hypothetical protein DKFZp434G0522 660
421111 BE299047 Hs 43532 ESTs Weakly similar to T20177 hypotheti 6 60
407424 AF120493 gb Homo sapiens elastase 1 precursor (EL 659
412396 AW947895 gb PM1-MT0010-200300-001-f10 MT0010 Homo 6 57
416209 AA236776 Hs 79078 MAD2 (mitodc arrest deficient, yeast, h 6 57
406674 AA332152 Hs 288036 tRNA isopentenylpyrophosphate traπsferas 657
400860 NA 656
457893 AA744292 gb ny51d05 s1 NCI_CGAP_Pr18 Homo sapiens 655
426108 AA622037 Hs 166468 programmed cell death 5 654
422133 AW612779 Hs 333159 Homo sapiens laryngeal carcinoma related 654
421044 AF061871 Hs 311736 Human DNA sequence from clone RP1-238D15 654
414136 AA812434 Hs 119023 SMC2 (structural maintenance of chromoso 653 400351 AF060169 Hs 272369 Homo sapiens AS11 protein mRNA, partial 652
413670 AB000115 Hs 75470 hypothedcal protein, expressed in osteo 6 52
410416 BE410072 Hs 63304 protein phosphatase methylesterase-1 650
419852 AW503756 Hs 286184 hypothetical protein dJ551D25 6 50
419677 N77342 Hs 21851 Homo sapiens cDNA FU 12900 fis, clone NT 650
431806 AF186114 Hs 270737 tumor nxrosis fxtor (ligand) superfami 650
429774 AI522215 Hs 50883 KIAA1804 protein 650
428228 AA424352 Hs 210586 ESTs 650
418134 AA397769 Hs 86617 ESTs 650
403859 NA NA 650
422704 AA972147 Hs 132275 ESTs 650
416737 AF154335 Hs 79691 LIM domain protein 650
429854 R55508 Hs 99472 ESTs 650
422672 X12784 Hs 119129 collagen, type IV, alpha 1 649
453600 BE246211 Hs 119120 E3 ubiquitin ligase SMURF1 648
454835 AW833763 gb QV4-TT0008-130100-077-d10110008 Homo 648
434603 AF147384 gb Homo sapiens full length insert cDNA 648
408243 Y00787 Hs 624 interieukin 8 648
429317 AA831552 Hs 268016 Homo sapiens cDNA FU21243 fis, clone C 647
451316 AI770011 Hs 208310 ESTs 646
448339 AL035920 Hs 20938 RNA binding modf, single stranded inter 646
433423 BE407127 Hs 8997 heat shxk 70kD protein 1 A 644
410358 AW975168 Hs 13337 ESTs, Weakly simila to unnamed protein 644
434025 AF114264 Hs 216381 Homo sapiens clone HH409 unknown mRNA 642
440526 AI832243 Hs 211471 ESTs 642
432727 AA305233 Hs 278712 eukaryodc translation initiation fxtor 641
433009 AA761668 gb nz24c08 s1 NCI_CGAP_GC81 Homo sapiens 640
435782 N49433 Hs 285737 Homo sapiens cDNA FU20895 fis, done A 640
415071 AK002197 Hs 284270 Homo sapiens cDNA FU 11335 fis, ctone PL 640
407162 N63855 Hs 142634 zinc finger protein 640
446152 AI292036 Hs 150028 ESTs 640
422828 AL133396 Hs 121281 pπon protein 2 (dublet) 640
418866 T65754 gb yc11c07 s1 Stratagene lung (937210) H 640
411411 AA345241 Hs 55950 ESTs, Weakly similar to Kl AA1330 protein 640
429039 AI524793 Hs 301897 ESTs 640
447254 NM 004153 Hs 1 908 ongm recognidon complex subunit 1 (y 640
435159 AA668879 Hs 116649 ESTs 640
429625 AA455568 Hs 193814 ESTs 640
430180 AA331406 Hs 75456 A kinase (PRKA) anchor protein 10 640
408420 NM_006915 Hs 44766 rednids pigmentosa 2 (X-lmked rxessi 640
426572 AB037783 Hs 170623 hypothetical protein FU11183 640
449911 AI262106 Hs 12653 ESTs 640
440105 AA694010 Hs 6932 Homo sapiens clone 23809 mRNA sequence 640
440395 AA884412 Hs 216342 ESTs 6 37
429500 X78565 Hs 289114 hexabrxhion (tenascin C, cytotxdn) 637
417771 AA804698 Hs 82547 rednoic xid rxeptor responder (tazaro 636
417092 H97508 Hs 181165 eukaryodc translation elongation fxtor 636
412227 AW902282 gb QV3-NN1023-260400-169-g10 NN1023 Homo 636
400845 NA 636
403546 NA NA 636
412345 AW938386 gb PM4-DT0057-201299-002-G10 DT0057 Homo 635
422186 AW962364 Hs 129051 ESTs 634
426990 AL044315 Hs 173094 Homo sapiens mRNA for KIAA1750 protein, 634
417687 AI828596 Hs 250691 ESTs 6 33
426223 AW977812 Hs 130391 ESTs 632
417588 Z44510 gb HSC22D091 normalized infant brain cDN 632
432629 AW860548 Hs 280658 ESTs 631
440495 AA887212 Hs 14161 hypothedcal protein DKFZp434H930 631
407771 AL138272 Hs 62713 ESTs 6 31
417517 AF0O1176 Hs 82238 P0P4 (prxessmg of precursor , S cerev 630
431041 AA490967 Hs 197955 KIAA0704 protein 630
445571 AI378000 Hs 158489 ESTs, Weakly simila to Z184_HUMAN ZINC 630
433309 AA807060 Hs 126558 ESTs 630
415659 W27214 Hs 78547 zinc finger protein (clone 647) 630
420271 AI954365 Hs 42892 ESTs 630
426921 AA037145 Hs 172865 cleavage sd uladon fxtor, 3' pre-RNA, 630
400950 NA NA 630
429692 N48422 Hs 9977 ESTs, Weakly simila to B34087 hypothed 630
439813 AA846321 Hs 124501 ESTs 6 30
449444 AW818436 Hs 23590 solute earner family 16 (monxartjoxytic 630
453596 AA441838 Hs 62905 hypothedcal protein FU 14834 630
446847 T51454 Hs 82845 Homo sapiens cONA FLJ21930 fis, clone H 630
435820 AA700580 Hs 189000 ESTs 630
452576 AB023177 Hs 29900 KIAA0960 protein 630
448924 AW450569 Hs 188399 ESTs 630
424343 AW956360 Hs 4748 adenylate cyclase xdvadng polypepdde 630
412591 BE217736 Hs 292653 ESTs, Weakly simila to T26845 hypotheti 630
426642 AW068223 Hs 171581 ubiquidn C-terminal hydrolase UCH37 630
419088 AI538323 Hs 52620 integnn, beta 8 6 30
401424 NA 630
412189 R60982 Hs 22581 ESTs 630
435501 AW051819 Hs 129908 KIAA0591 protein 630
408221 AA912183 Hs 47447 ESTs 6 28 413943 AW294416 Hs 144687 Homo sapiens cDNA FU12981 fis, clone NT 6 28
416845 H95279 gb yu20h02 s1 Soares fetal liver spleen 627
402732 NA NA 6 26
413224 AI732470 Hs 191157 ESTs, Weakly similar to ALU7.HUMAN ALU S 624
415642 U19878 Hs 336224 transmembrane protein with EGF-like and 6 24
449284 BE502240 Hs 38592 hypothedcal protein FU23342 624
419548 AW978142 Hs 326248 Homo sapiens cDNA FU22071 fis, clone H 623
453880 AI803166 Hs 28462 ESTs, Weakly similar to I38022 hypothed 6 22
422675 BE018517 Hs 119140 eukaryodc translation initiation fxtor 622
413384 NM 000401 Hs 75334 exostoses (muldple) 2 6 21
445584 AF217518 Hs 8360 PTD012 protein 621
451065 AW295132 Hs 222231 ESTs, Weakly simila to granule cell mar 6 21
420807 AA280627 Hs 57846 ESTs 620
421155 H87879 Hs 102267 lysyl oxidase 620
441421 AA356792 Hs 334824 hypothedcal protein FU 14825 620
440209 H05049 Hs 22269 neurexin 3 620
408170 AW204516 Hs 31835 ESTs 620
433590 N98410 Hs 48364 Homo sapiens regulator of G-protem sign 620
442008 AI457814 Hs 270272 ESTs 620
420617 AK001652 Hs 99423 ATP-dependent RNA helicase 620
402343 NA 620
432682 AI376400 Hs 159588 ESTs 620
452109 AI525873 Hs 61164 hypothedcal protein FU14909 620
429954 AI918130 Hs 21374 ESTs 620
417256 U94332 Hs 81791 tumor nxrosis fxtor receptor superfami 620
435525 AI831297 Hs 123310 ESTs 620
413604 R51767 gb yg73g11 r1 Soaes infant bran 1NIB H 620
425305 AA363025 Hs 155572 Human clone 23801 mRNA sequence 620
443285 AI301918 Hs 334264 ESTs 620
446565 D13757 Hs 311 phosphoπbosyl pyrophosphate amidotransf 620
451027 AW519204 Hs 40808 ESTs 620
452243 AL355715 Hs 28555 programmed cell death 9 619
429782 NM 005754 Hs 220689 Ras-GTPase-xdvadng protein SH3-doman 6 17
424060 X92108 Hs 138629 H sapiens mRNA for subtelomeπc repeat s 6 17
432494 AA551060 gb nk74(02s1 NCI_CGAP_Sch1 Homo sapiens 6 16
448186 AA262105 Hs 4094 Homo sapiens cDNA FU14208 fis, clone NT 614
419638 N46504 Hs 91747 profilin 2 613
445595 W25950 Hs 14512 DIPB protein 6 13
433036 AA574091 Hs 105964 ESTs 613
457155 AL110243 Hs 187991 DKFZP564A122 protein 6 13
443715 AI583187 Hs 9700 cyclm E1 6 13
422867 L32137 Hs 1584 cartilage oligomeπc matπx protein (pse 612
453286 AA034319 Hs 29041 Homo sapiens CDNA FU14177 fis clone NT 6 11
424897 D63216 Hs 153684 fπzzled-related protein 6 11
429188 AB011171 Hs 198037 KIAA0599 protein 611
434894 AW977850 Hs 23856 hypothedcal protein MGC5297 610
413339 AI818080 Hs 194290 ESTs 6 10
453685 AL110309 gb DKFZp564L0278_r1 564 (synonym hfbr2) 6 10
421195 BE464560 Hs 133017 ESTs 610
453296 AA034413 Hs 62560 ESTs 6 10
444985 AI677737 Hs 28329 hypothedcal protein FU 14005 610
423492 AF020761 Hs 129683 ubiquitm-conjugating enzyme E2D 1 (homo 6 10
419841 BE005848 Hs 7326 ESTs 610
429190 H18650 Hs 92602 ESTs 6 10
426116 AA868729 Hs 144694 ESTs 6 10
451441 AA017601 Hs 84529 ESTs, Weakly simila to Z202.HUMAN ZINC 6 10
401740 NA 6 10
441953 H11695 Hs 322901 disrupter of silencing 10 6 10
401464 AF039241 Hs 9028 histone dexetylase 5 610
405033 NA 610
410743 AA089474 Hs 272153 ESTs 6 10
454758 AW845266 gblL2-CT0031-160999-003-B08 CT0031 Homo 610
417728 AW138437 Hs 24790 KIAA1573 protein 6 10
418553 T88964 gb yd97a07 r1 Soares fetal liver spleen 609
431617 AK000738 Hs 264636 hypothedcal protem FU20731 608
455608 BE011437 gb CM4-BN0220-080500-170-f03 BN0220 Homo 608
450755 AA010984 Hs 159464 ESTs 607
455217 AW867534 gb MRO-SN0037-160400-004-e05 SN0037 Homo 607
437179 AA393508 Hs 300642 serologically defined colon cancer andg 606
408622 AA056060 Hs 202577 Homo sapiens cDNA FU12166 fis, clone MA 606
415308 F05251 gb HSC04H101 normalized infant bran cDN 606
428417 AK001699 Hs 184227 F-box only protein 21 605
426501 AW043782 Hs 293616 ESTs 603
431077 AI669133 Hs 115660 hypothedcal protein FU 12810 603
403040 NA 602
445704 AI493742 Hs 165210 ESTs, Moderately similar to I38022 hypot 602
415637 R2551 gb yg44(D1 r1 Soares infant bran 1NIB H 602
427925 N51323 Hs 255935 Homo sapiens, clone IMAGE 3448993, mRNA 602
404702 NA NA 602
433183 AF231338 Hs 222024 transcnpdon fxtor BMAL2 601
437762 T78028 Hs 154679 synaptotagmin I 601
443833 AI654108 Hs 135125 ESTs 601
422263 AA307639 Hs 129908 KIAA0591 protein 600 420909 AI640551 Hs 88878 Homo sapiens cDNA FU23536 fis clone L 600
407612 U26403 Hs 37142 ephπn-A5 600
450715 AI266484 Hs 31570 ESTs, Weakly similar to KIAA1324 protein 600
453853 AL0406OO Hs 188083 ESTs 600
444188 AI393165 Hs 699 pepddylprolyl isomerase B (cyclophilm 600
451813 NM 016117 Hs 27182 phospholipase A2-xdvadng protein 600
422505 AL120862 Hs 124165 ESTs 600
420734 AW972872 Hs 293736 ESTs 600
455082 BE148180 gb RCO-HT0232-211099-011-e04 HT0232 Homo 600
444200 AA327113 Hs 149057 ESTs 600
447432 AW958473 Hs 301957 nudix (nucleoside dφhosphate linked oi 600
419752 AA249573 Hs 152618 ESTs, Moderately simila to ZN91 HUMAN Z 600
428412 AA428240 Hs 126083 ESTs 600
407790 AI027274 Hs 288941 Homo sapiens cDNA FU 14866 (is, clone PL 600
428945 AW192803 Hs 98974 ESTs, Weakly similar to S65824 reverse I 600
431878 AA521207 Hs 270202 ESTs, Weakly simila to ALU4_HUMAN ALU S 600
425282 AW163518 Hs 155485 hundngdn interxdng protein 2 600
401093 NA 600
411861 AW867875 gb MRO-SN0040-050500-003-f11 SN0040 Homo 600
411800 N39342 Hs 103042 microtubule-associated protein 1B 599
446925 AW974605 Hs 176669 ESTs 598
401708 NA NA 598
449894 AK001578 Hs 24129 CLLL7 protein 597
403278 NA NA 596
455212 AW866330 gb QV4-SN0024-080400-167-e01 SN0024 Homo 596
410116 AW630671 Hs 58636 squamous cell carcinoma andgen recogniz 596
441271 AA927290 Hs 130462 ESTs 595
404072 NA 595
431596 T34708 Hs 272927 Sx23 (S cerevisiae) homolog A 594
421622 AB037748 Hs 106204 KIAA1327 protein 593
441300 R35063 Hs 181536 ESTs 592
445517 AF208855 Hs 12830 hypothedcal protein 591
429559 AI985345 Hs 26425 ESTs 591
443767 BE562136 Hs 9736 proteasome (prosome, mxropain) 26S subu 591
440510 H08427 Hs 309165 ESTs, Weakly simila to ISHUSS protein d 590
414727 BE466904 gb hz28f03 x1 NCI CGAP GC6 Homo sapiens 590
451686 AA059246 Hs 110293 ESTs 590
438032 BE045624 Hs 152992 ESTs 590
450470 Z75330 Hs 286148 stromal antigen 1 590
430533 AA480895 Hs 201552 ESTs, Weakly similar to T17288 hypotheti 590
432662 AL049314 Hs 280700 ESTs 5 90
451742 T77609 Hs 117970 ankyπn 2, neuronal 590
431217 NM 013427 Hs 250830 Rho GTPase xdvadng protein 6 590
412537 AL031778 Hs 797 nuclear transcπption fxtor Y alpha 590
447233 AW246333 Hs 17901 Homo sapiens, clone IMAGE 3937015, mRNA, 590
410804 U64820 Hs 66521 Mxhado-Joseph disease (spinocerebellar 590
452619 AW298597 Hs 61884 Homo sapiens, clone IMAGE 4298026, mRNA, 590
433865 N29862 Hs 44104 ESTs 590
453403 BE466639 Hs 61779 Homo sapiens cDNA FU13591 fis clone PL 590
448743 AB032962 Hs 21896 KIAA1136 protein 590
447153 AA805202 Hs 315562 ESTs 590
425793 AA363946 Hs 20969 ESTs 590
404632 NA 590
446364 AB006624 Hs 14912 KIAA0286 protein 5 90
452240 AI591147 Hs 61232 ESTs 590
410424 AA084984 gb zn11a08 r1 Stratagene hNT neuron (937 590
404170 NA 589
458390 AI792585 Hs 133272 ESTs, Weakly similar to ALUC HUMAN 589
408296 AL117452 Hs 44155 DKFZP586G1517 protein 588
444406 AI147237 Hs 300697 immunoglobulin heavy constant gamma 3 (G 587
413894 BE177983 gb RC3-HT060O-2303O0-021-g10 HT0600 Homo 587
453922 AF053306 Hs 36708 budding uninhibited by benzimidazoles 1 586
446700 AW206257 Hs 156326 Human DNA sequence from clone RP11-145L2 5 86
443377 AI792547 Hs 133292 ESTs 586
419162 AA234591 Hs 304123 ESTs 585
436608 AA628980 Hs 192371 down syndrome cπdcal region protein DS 584
428650 AI560456 Hs 107319 ESTs 584
437410 AW023340 Hs 14880 ESTs 584
428303 AW974476 Hs 183601 regulator of G-protem signalling 16 584
401004 NA 583
414504 AW069181 Hs 115175 steπle-alpha modf and leucine zipper c 583
410979 BE151480 gb RC0-HT0295071199-011-301 HT0295 Homo 582
424576 BE154142 Hs 96833 ESTs 582
439352 BE614347 Hs 169615 hypothetical protein FU 20989 581
423057 AW961597 Hs 130816 ESTs. Moderately similar to 138022 hypot 580
429250 H56585 Hs 198308 tryptophan rich basic protein 580
413048 M93221 Hs 75182 mannose rxeptor, C type 1 580
451367 AA923729 Hs 26322 cell cycle related kinase 580
418647 AA226198 gb nc26a07s1 NCI_CGAP_Pr1 Homo sapiens 580
421589 AW954177 Hs 82919 cullm 2 580
427969 NM 001963 Hs 2230 epidermal growth fxtor (beta-urogastron 580
451406 AI694320 Hs 6295 ESTs, Weakly simila to T17248 hypothed 580
436096 H55931 Hs 269582 ESTs 580 443353 AI052659 Hs 133255 ESTs 580
457244 AA581385 Hs 162473 ESTs, Weakly similar to I38022 hypotheti 580
407746 AKO01962 Hs 38114 hypothetical protein FU11100 580
440688 AW404591 Hs 147440 ESTs, Weakly similar to Z192.HUMAN ZINC 580
445745 AB0O7924 Hs 13245 KIAA0455 gene product 580
405637 NA NA 580
415293 R49462 Hs 106541 ESTs 580
440404 AI015881 Hs 324527 itxhondπal πbosomal protein S5 580
442227 AW771958 Hs 175437 ESTs, Moderately similar to PC4259 fem 580
423395 AA326613 gb EST29922 Cerebellum II Homo sapiens c 580
410555 U92649 Hs 64311 a dismtegnn and metalloproteinase doma 580
416000 R82342 Hs 79856 ESTs, Weakly similar to S65657 alpha-1C- 580
422108 AA297914 Hs 111749 postmeiodc segregadon increased (S ce 580
430818 AI311928 gb qo89h04 x1 NCI CGAP_Kιd5 Homo sapiens 580
444749 AI190672 Hs 65926 ESTs 580
417515 L24203 Hs 82237 ataxia-telangiectasia group D-assxiated 579
456192 D84109 Hs 80248 RNA-bind g protein gene with muldple s 578
411253 AW833897 gb QVO-TT0009-111199-055b07 TT0009 Homo 578
417219 AW973473 Hs 220936 ESTs 578
409450 AW628650 Hs 61260 hypothedcal protein FU13164 576
412013 AA400753 Hs 43761 ESTs, Weakly similar to A46010 X-linked 576
425566 AW162943 Hs 250618 UL16 binding protein 2 575
417877 AI025829 Hs 86320 ESTs 575
437114 AA836641 Hs 163085 ESTs 575
421238 AB033101 Hs 102796 Homo sapiens cDNA FU 10708 fis, clone NT 574
428959 AF100779 Hs 194680 WNT1 inducible signaling pathway protein 573
415209 F00183 Hs 172004 ddπ 573
429922 Z97630 Hs 226117 H1 histone family, member 0 572
420022 AA256253 Hs 120817 ESTs 571
431485 BE621320 Hs 257486 hypothedcal protein FU20062 5 71
424304 NM 001395 Hs 144879 dual spxificity phosphatase 9 571
434276 AF123659 Hs 93605 leucine zipper, putadve tumor suppresso 571
438085 R52518 Hs 7967 ESTs 570
444379 N99035 Hs 222657 ESTs 570
401348 NA NA 570
428878 AA436884 Hs 48926 ESTs 570
422564 AI148006 Hs 222120 ESTs 570
452560 BE077084 Hs 336432 ESTs 570
408384 BE144344 Hs 7589 ESTs, Weakly simila to A46010 X-lmked 570
409948 AA078643 gb 7P08B01 Chromosome 7 Plxental cDNA L 570
421166 AA305407 Hs 102308 potassium inwardly rectifying channel, s 570
439231 AW581935 Hs 141480 Homo sapiens mRNA, cDNA DKFZp434N079 (fr 570
439203 AA448930 Hs 8453 KIAA1587 protein 570
442029 AW956698 Hs 14456 neural precursor cell expressed, develop 5 70
451922 BE463995 Hs 211033 ESTs 570
407808 AA663559 Hs 279789 histone dexetylase 3 570
428161 M96954 Hs 182741 TIA1 cytotoxic granule-assxiated RNA-bi 570
413430 R22479 Hs 167073 Homo sapiens cDNA FU 13047 fis, clone NT 570
428223 AA424313 Hs 98402 ESTs 570
427972 AA864870 Hs 181304 putadve gene product 570
416283 NM 005429 Hs 79141 vascular endothelial growth fxtor C 570
416319 AI815601 Hs 79197 CD83 antigen (xdvated B lymphxytes, i 570
458044 AW979114 Hs 326135 ESTs 5 70
432911 AW807634 Hs 279799 putadve zinc finger protein NY-REN 34 a 5 70
411643 AI924519 Hs 192570 hypothetical protein FU22028 570
408867 AA437199 Hs 656 cell division cycle 25C 570
428679 AA431765 gb zw80c03 s1 Soares_tesds_NHT Homo sap 570
428822 W28418 Hs 30715 potassium voltage-gated channel, Isk-rel 570
409570 AW418720 Hs 167583 ESTs 570
457441 BE467737 Hs 146125 ESTs 570
409101 NM 004297 HS 50612 guanine nucleotide binding protein (G pr 570
420192 AA256281 Hs 105040 ESTs 569
423582 BE000831 Hs 23837 Homo sapiens cDNA FU 11812 fis, clone HE 569
454511 AW948146 gb RCO-MT0013-280300-031-e02 MT0013 Homo 568
419586 AI088485 Hs 144759 ESTs, Weakly similar to I38022 hypotheti 567
416777 AF146760 Hs 79844 DKFZP564M1416 protein 567
435849 BE305242 Hs 16098 claudin 2 567
457892 AA744389 gb ny51e10 s1 NCI CGAP Pr18 Homo sapiens 566
450191 AW137243 Hs 222446 ESTs 566
438653 AW188099 Hs 131813 ESTs 566
422910 AI269508 Hs 121591 Human DNA sequence from PAC 257A7 on chr 566
453694 AW504918 Hs 258208 Homo sapiens, clone MGC 15606 mRNA, com 566
445302 AK001537 Hs 12488 hypothetical protein FU10675 566
446080 AI221741 Hs 117777 ESTs 565
425474 Z48054 Hs 158084 peroxisome rxeptor 1 565
432542 AW083920 Hs 16098 claudin 2 565
446983 AA157484 Hs 97199 complement component C1q rxeptor 565
420898 A8002379 Hs 100113 KIAA0381 protein 565
401372 NA 564
428541 AI862570 Hs 299214 Homo sapiens, clone IMAGE 2822295, mRNA, 563
426249 F05422 Hs 168352 nucleoponn-like protein 1 563
459705 BE082764 Hs 270252 ESTs, Weakly similar to androgen rxepto 563
451863 AL120634 Hs 305923 ATPase, Caw- transporting, plasma membra 562 426316 NM_002430 Hs 268515 meningioma (disrupted in balanced fransl 562
401183 NA 562
426029 AW294138 Hs 255277 ESTs 561
443462 AI064690 Hs 171176 ESTs 561
447102 BE167434 Hs 98471 ESTs, Weakly simila to T18712 hypothed 560
419150 T29618 Hs 89640 TEK tyrosine kinase, endothelial (venous 560
444577 AI207721 Hs 11393 RAD51 (S cerevisiae) homolog C 560
423605 AF047826 Hs 129887 cadheπn 19, type 2 560
413447 AW969388 Hs 10450 Homo sapiens cDNA FLJ22063 fis, clone H 560
442957 AI949952 Hs 49397 ESTs 560
424296 AI631874 Hs 155140 casein kinase 2, alpha 1 polypepdde 560
430679 R44428 Hs 22801 ESTs 560
449358 AA001229 Hs 131436 ESTs 560
418348 AI537167 Hs 96322 hypothedcal protein FU23560 560
433133 AB027249 Hs 104741 PDZ-bindmg kinase, T-cell oπgmated pr 560
444059 R69743 Hs 116774 integnn, alpha 1 560
438157 AW137011 Hs 49576 ESTs 560
428233 AI358831 Hs 20578 ESTs 560
434265 AA846811 Hs 130554 Homo sapiens cDNA FU23089 fis, clone L 560
451652 AA018968 Hs 133536 ESTs 559
422762 AL031320 Hs 119976 Human DNA sequence from clone RP1-20N2 o 559
447591 AI675417 Hs 282855 ESTs 558
417958 AA767382 Hs 193417 ESTs 557
438146 Z36842 Hs 57548 ESTs 557
413595 AW235215 Hs 16145 ESTs 557
422406 AF025441 Hs 116206 Opa-mterxdng protein 5 556
420529 D25259 Hs 319844 ESTs, Moderately similar to I54374 gene 556
439582 W79161 Hs 118327 Homo sapiens cDNA FU11522 fis, clone HE 556
408744 AW806177 gb MR1-UM0108-130400-003-d04 UM0108 Homo 556
447230 AW972147 Hs 101395 hypothedcal protein MGC11352 554
428856 AA436735 Hs 183171 hypothedcal protein FU22O02 554
446813 AA971436 Hs 16218 KIAA0903 protein 553
451424 AI862026 Hs 302810 Novel human gene mapping to chomosome 20 553
410516 BE537917 Hs 90034 hypothetical protein FU21916 553
453994 BE180964 Hs 165590 nbosomal protein S13 553
435583 AA767714 Hs 291627 ESTs 552
431585 BE242803 Hs 262823 hypothedcal protein FU10326 551
408912 AB011084 Hs 48924 KIAA0512 gene product ALEX2 551
427966 R97130 Hs 189699 ESTs 551
433611 AW327692 Hs 3446 mitogen-xdvated protein kinase kinase 551
401244 NA 550
410784 AW803201 gb IL2-UM0077-070500-080-E06 UM0077 Homo 550
434006 AF113688 gb Homo sapiens clone FLB4630 550
425650 NM 001944 Hs 1925 desmoglein 3 (pemphigus vulgaπs andgen 550
427507 AF240467 Hs 179152 toll-like receptor 7 550
423268 BE386898 Hs 131162 ESTs, Weakly similar to ALU5_HUMAN ALU S 550
405065 NA NA 550
444302 AI140115 Hs 225130 ESTs 550
418183 NM 001772 Hs 83731 CD33 andgen (gp67) 550
435586 AI279137 Hs 151498 ESTs 550
438279 AA805166 Hs 154762 HIV-1 rev binding protein 2 550
427189 H82453 Hs 5635 ESTs 550
415263 AA948033 Hs 130853 ESTs 550
441818 AI630451 Hs 7976 KIAA0332 protein 550
407834 AW084991 Hs 26100 ESTs 550
404012 NA NA 550
449932 AI675444 Hs 263024 ESTs 550
423760 AA775891 Hs 191980 ESTs 550
431576 M76665 Hs 275215 hydroxysteroid (11-beta) dehydrogenase 1 550
423172 R15652 gb HH503-F Adult heart, Clontech Homo sa 550
422295 AF051151 Hs 114408 toll-like receptor 5 550
429044 AI261490 Hs 145527 ESTs 550
433280 AA581404 Hs 289037 Homo sapiens cDNA FU14135 fis, clone MA 550
414323 NM 014759 Hs 334688 KIAA0273 gene product 550
405511 NA NA 549
444665 BE613126 Hs 47783 B aggressive lymphoma gene 549
434434 AA633516 Hs 157201 ESTs 548
421997 R66740 Hs 110613 KIAA0220 protein 547
410276 AI554545 Hs 68301 ESTs 547
435867 AA954229 Hs 114052 ESTs 547
453837 AL138387 Hs 256126 bxuloviral IAP repeat-containing 7 (liv 547
409617 BE003760 Hs 55209 Homo sapiens mRNA cDNA DKFZp434K0514 (f 547
430387 AW372884 Hs 240770 nuclear cap binding protein subunit 2, 2 547
401629 NA NA 546
433071 BE150229 Hs 281564 retinal outer segment membrane protein 1 546
458247 R14439 Hs 209194 ESTs 546
418049 AA211467 Hs 190488 Homo sapiens, Simila to nuclea Ixaliz 545
418247 R55174 gb yg87h04 r1 Soares infant bran 1NIB H 545
453716 AA037675 Hs 152675 ESTs 544
431157 AI823969 Hs 132678 ESTs 544
426873 AH 90540 Hs 131092 ESTs 543
437092 AA744292 gb ny51d05 s1 NCI_CGAP_Pr18 Homo sapiens 542
445782 AW407672 Hs 315367 Homo sapiens, Similar to hypothedcal pr 542 447393 AI377458 Hs 158831 EST 542
425283 AA354338 Hs 131100 ESTs 542
401208 NA NA 542
430536 AI809163 Hs 9908 nitrogen fixadon cluster-like 542
405523 NA 542
409012 AL117435 Hs 49725 DKFZP434I216 protein 541
429803 W81489 Hs 223025 RAB31, member RAS oncogene family 541
436982 AB018305 Hs 5378 spondin 1, (f-spondin) extrxellula mat 540
422892 AA988176 Hs 121553 hypothedcal protein FU20641 5 0
456027 BE327387 Hs 13913 KIAA1577 protein 540
411897 AW875066 Hs 326876 Homo sapiens S0X6 mRNA complete eds 540
449689 AF228421 Hs 23889 DKFZP564A032 protein 540
432865 AI753709 Hs 152484 ESTs, Weakly simila to I38022 hypothed 540
408248 AW854832 gb QV2-CT0261-201099-011-f05 CT0261 Homo 540
418516 NM 006218 Hs 85701 phosphoιnosιdde-3-kιnase, catalytic, al 540
423289 N77774 gb yz83e01 r1 Soares muldple sclerosis 540
453365 AA035211 Hs 17404 ESTs 540
406465 NA 540
441858 AW173339 Hs 135665 ESTs 540
432507 BE391093 Hs 324667 ESTs 540
440570 AI205712 Hs 125998 ESTs 540
445062 AI339915 Hs 44324 ESTs 540
421639 NM 012082 Hs 106309 Fnend of GATA2 540
410406 AI969703 Hs 1466 glycerol kinase 540
418939 AW630803 Hs 89497 lamin B1 540
426010 AA136563 Hs 1975 hypothedcal protein FU21007 540
400250 NA NA 540
424650 AW576156 Hs 250824 Homo sapiens cDNA FU23435 fis, clone H 540
414998 NM 002543 Hs 77729 oxidised low density lipoprotein (Ixdn 5 39
433384 AI021992 Hs 124244 ESTs 538
428781 AF164799 Hs 193384 putatadve 28 kDa protein 538
438150 AA037534 Hs 79059 transforming growth fxtor, beta recepto 538
400639 NA 538
426485 NM 006207 Hs 170040 platelet-deπved growth fxtor receptor- 5 37
424205 AA336825 gb EST41732 Endometnal tumor Homo sapie 536
459596 H29554 Hs 113871 ESTs 536
408234 AW993356 Hs 285814 sprouty (Drosophila) homolog 4 536
414547 T47770 Hs 191463 ESTs 535
419851 AA287987 Hs 13477 ESTs, Weakly similar to 1207289A reverse 535
411945 AL033527 Hs 92137 v-myc avian myelxytomatosis viral oncog 534
425764 AW996009 Hs 112572 Homo sapiens cDNA FU14130 fis, clone MA 534
405352 NA 5 33
448030 N30714 Hs 325960 membrane-spanning 4-domans, subfamily A 532
424284 BE541008 Hs 6193 hypothedcal protein FU 14590 532
427741 AW753185 Hs 180628 dynamm 1-lιke 5 31
426021 AW770897 Hs 34392 ESTs, Weakly similar to I38022 hypothed 531
442186 AA984083 Hs 269746 ESTs, Weakly similar to T03306 PSD-95/SA 5 30
437319 BE410958 Hs 56406 Homo sapiens cDNA FU 13549 fis, clone PL 530
405287 NA NA 530
427032 AF012023 Hs 173274 integnn cytoplasmic domain-assxiated p 530
415371 R15239 gb yf89b02 r1 Soares infant brain 1 NIB H 530
420024 AA252905 Hs 194477 E3 ubiquitin ligase SMURF2 530
434408 AI031771 Hs 132586 ESTs 530
434739 AA804487 Hs 144130 ESTs 530
421327 AA837295 Hs 188802 ESTs 5 30
453058 AW612293 Hs 288684 Homo sapiens cDN A FU 11750 fis, clone HE 530
448776 BE302464 Hs 30057 MRS2 (S cerevisiaeHike, magnesium hom 530
417845 AL117461 Hs 82719 Homo sapiens mRNA, cDNA DKFZp586F1822 (f 5 30
430264 AA470519 gb nc71f10 s1 NCI.CGAP_Pr1 Homo sapiens 530
411402 BE297855 Hs 69855 NRAS-related gene 5 30
419220 AA811938 Hs 291759 ESTs 530
407995 AI094748 Hs 100134 hypothedcal protein FU 12787 530
459256 AW967468 Hs 99821 hypothetical protein FU14547 530
452449 AW068658 Hs 20943 ESTs 530
430366 AI057368 Hs 105575 ESTs 530
434360 AW015415 Hs 127780 ESTs 530
422560 F11469 Hs 118281 zinc finger protein 266 529
441704 AI458766 Hs 201988 ESTs 529
443635 AI080230 Hs 134214 ESTs 529
434342 AI791138 Hs 116768 ESTs 529
423409 NM_006466 Hs 128207 polymerase (RNA) III (DNA dirxted) (39k 529
449000 U69560 Hs 3826 kelch-dke protein C3IP1 529
452381 H23329 Hs 290880 ESTs, Weakly similar to ALU1_HUMAN ALU S 529
409068 AW236991 Hs 102495 ESTs, Moderately similar to I38022 hypot 529
434860 AA932386 Hs 292667 ESTs 528
408096 BE250162 Hs 83765 dihydrofolate reductase 528
418036 Z37976 Hs 83337 latent transforming growth fxtor beta b 5 28
435443 AI248674 Hs 14295 ESTs 526
414269 AA298489 Hs 303171 olfxtory receptor, family 51, subfamily 526
408371 AF161545 Hs 279883 hypothetical protein 5 26
401205 NA NA 526
450904 R07118 Hs 189924 ESTs 5 26
416351 H49704 Hs 173522 ESTs 526 426524 AA380611 Hs 163841 ESTs 5 25
412901 AI127359 Hs 289088 heat sh∞k 90kD protein 1, alpha 525
452487 AW207659 Hs 6630 Homo sapiens cDNA FLJ 13329 fis clone OV 5 24
444825 AW167613 Hs 248 mitogen xdvated protein kinase kinase 524
412953 Z45794 Hs 238809 ESTs 524
404117 NA NA 5 22
427956 AL046175 Hs 108169 Homo sapiens mRNA, cDNA DKFZp586C1619 (f 522
421787 AA227068 Hs 108301 nuclea receptor subfamily 2, group C, m 5 22
437255 R58970 Hs 9887 ESTs 522
424697 AL136169 Hs 250708 CAAX box l 520
449771 AI668702 Hs 54976 ESTs 520
432193 AA372264 Hs 273193 hypothedcal protein FU10706 520
438885 AI886558 Hs 184987 ESTs 520
407182 AA312551 Hs 230157 ESTs 520
452150 W42490 Hs 260844 ESTs 520
419680 AA249720 Hs 59335 ESTs 520
438940 AF075045 Hs 271609 ESTs 5 20
405362 NA NA 520
449370 AK002114 Hs 23495 hypothedcal protein FU 11252 520
442353 BE379594 Hs 49136 ESTs, Moderately similar to ALU7_HUMAN A 5 20
409331 M36634 Hs 53973 vasoxdve mtesdnal pepdde 520
415397 H10818 gb ym04f10 r1 Soaes infant bran 1NIB H 520
406735 AA603092 gb np37a01 s1 NCI_CGAP_Lu1 Homo sapiens 520
418489 U76421 Hs 85302 adenosine deaminase, RNA-spxific, B1 (h 520
431480 AA837274 Hs 257005 hypothedcal protein FU20837 520
425523 AB007948 Hs 158244 KIAA0479 protein 520
425673 R70318 Hs 339730 ESTs 5 20
439267 AA287747 Hs 173012 ESTs, Weakly simila to A46010 X-lmked 520
457030 AI301740 Hs 173381 dihydropyπmidinase-like 2 520
424638 AI472106 Hs 49303 Homo sapiens cDNA FU11663 fis, clone HE 5 20
454434 AA083558 Hs 261286 ESTs 520
448336 R53848 Hs 44976 ESTs 520
429534 AW976987 Hs 163327 ESTs, Weakly similar to 2109260A B cell 520
434803 AW974640 Hs 303413 ESTs 520
403199 NA NA 520
435225 AI021912 Hs 187983 ESTs 520
451664 AA889081 Hs 153952 5' πucleoddase (CD73) 5 20
440385 AA884283 Hs 192136 ESTs 520
432328 AI572739 Hs 195471 6-phosphofructo-2 kmase/fructose-2,6-bi 520
400484 NA 520
425757 AA363171 gb EST72986 Ovary II Homo sapiens cDNA 5 5 19
449841 AI671602 Hs 199602 ESTs 519
420303 AA258282 Hs 278435 KIAA1474 protein 519
429687 AI675749 Hs 211608 πucleoponn 153kD 5 19
453345 AA302862 Hs 90063 neurocalαn delta 5 18
447499 AW262580 Hs 147674 protocadhenn beta 16 518
404913 NA 5 18
405114 NA NA 518
431117 AF003522 Hs 250500 delta (Drosophιla)-lιke 1 5 18
411995 W49701 Hs 29667 ESTs 517
401736 NA NA 5 17
425250 AA353495 Hs 269762 ESTs, Weakly similar to A47582 B-cell gr 5 16
454388 AA630905 Hs 333300 hypothetical protein FLJ14026 5 16
449032 AA045573 Hs 22900 nuclear fxtor (erythroid-denved 2)-lιk 516
443646 AI085198 Hs 164226 ESTs 515
436032 AA150797 Hs 109276 latexin protein 515
456896 M97639 Hs 155585 receptor tyrosine kinase-like orphan rx 515
433672 BE281165 Hs 288038 TLS-assxiated seπne-argmme protein 1 515
432826 X75363 Hs 250770 ACO for senne protease homologue 514
439441 W67993 Hs 323135 ESTs 514
400205 NA NA 5 14
430854 AW440369 Hs 47026 ESTs 5 14
408771 AW732573 Hs 47584 potassium volt3ge-gated channel, delayed 514
456804 AI421645 Hs 139851 cavxlm 2 514
424690 BE538356 Hs 151777 eukaiyodc translation initiation fxtor 513
449210 AI635363 Hs 197636 ESTs 512
419013 T90378 Hs 14463 ESTs 5 12
425843 BE313280 Hs 159627 death assxiated protein 3 512
422545 X02761 Hs 287820 fibronxtin 1 512
424785 R23519 Hs 6126 hypothedcal protein dJ1141E152 511
442833 AA328153 Hs 88201 ESTs, Weakly similar to A Chan A, Cryst 510
422411 AW749443 Hs 22511 ESTs 510
457565 BE294029 Hs 279903 Ras homolog ennched in bran 2 510
437722 AW292947 Hs 122872 ESTs Weakly similar to JU0033 hypotheti 510
446893 AI610818 Hs 7110 ESTs 510
401581 NA 5 10
417511 AL049176 Hs 82223 chordm-like 5 10
422336 AI761322 Hs 115285 dihydrolipoamide S-xetyltransferase (E2 510
437662 AA765387 Hs 145095 ESTs 510
429526 AA454182 Hs 99360 ESTs 510
447332 AW445012 Hs 160918 ESTs 510
436207 AA334774 Hs 12845 hypothetical protein MGC13159 5 10
428155 H17012 Hs 14633 ESTs 510 420185 AL044056 Hs 158047 ESTs 510
445657 AW612141 Hs 279575 Homo sapiens G-protem coupled receptor 5 10
440913 AI267491 Hs 160593 ESTs 510
452943 BE247449 Hs 31082 hypothetical protein FLJ 10525 510
428603 BE241619 Hs 24641 cytoskeleton assxiated protein 2 5 10
436577 W84774 Hs 17643 ESTs 510
400241 NA NA 5 10
437205 AL110232 Hs 279243 Homo sapiens mRNA, cDNA DKFZp564D2071 (f 510
423654 AI674253 Hs 35828 ESTs 510
417637 AA204969 Hs 234863 Homo sapiens cDNA FU12082 fis, clone HE 510
430849 AI940727 Hs 270556 ESTs, Highly similar to AF156779 1 ASB-4 510
452605 AW968557 Hs 90012 hypothedcal protein FU23441 510
440381 AA917808 Hs 190495 ESTs 510
441033 BE562555 gb 601335867F1 NIH.MGC.44 Homo sapiens c 510
450229 R18717 Hs 8929 hypothedcal protein FLJ 11362 510
447197 R36075 gb yh88t>01 s1 Soaes placenta Nb2HP Homo 510
442150 AI368158 Hs 70983 PTPL1 -assxiated RhoGAP 1 510
415651 AI207162 Hs 3815 stathmin-like-protem RB3 510
453655 AW960427 Hs 79059 transforming growth fxtor, beta recepto 509
434442 AA737415 Hs 152826 ESTs 509
429389 AA454779 Hs 201441 Homo sapiens cDNA FU11079 fis, ctone PL 509
435419 AI281068 Hs 152835 ESTs 509
427620 NM 003705 Hs 1 9866 solute earner family 25 (mitochondπal 509
445706 AA305520 Hs 108812 hypothedcal protein FU22004 508
424071 R71340 Hs 12876 ESTs 508
428227 AA321649 Hs 2248 small inducible cytokine subfamily B (Cy 508
426400 M78361 Hs 169743 Homo sapiens clone 25121 neuronal dfxt 508
429026 AA443385 Hs 221993 ESTs 508
455847 BE146775 gb QV4-HT0222-181099-013-eO4 HT0222 Homo 508
416110 Z42262 Hs 322844 hypothedcal protein DKFZp564A176 508
436854 AA749167 Hs 173911 ESTs 508
421799 AW972292 Hs 292998 ESTs 508
452154 AW953265 Hs 302746 MSTP028 protein 506
444946 AW139205 Hs 156457 hypothedcal protein FU22408 506
445950 AI267957 Hs 145706 ESTs 506
443124 AI033500 Hs 132895 ESTs 506
440698 AI348455 Hs 147492 Homo sapiens cDNA FU11777 fis, clone HE 506
444713 AW812074 Hs 28631 Homo sapiens cDNA FU22141 fis, clone H 506
447970 AW086109 H Hss 2200113366 chromosome X open reading frame 6 506
419307 AW953190 HHss 2233118800 ESTs 506
421954 AA410245 HHss 4400332233 BUB3 (budding uninhibited by benzimidazo 506
451807 W52854 HHss 2277009999 hypothetical protein FU23293 similar to 505
421782 AB029290 Hs 108258 xdn binding protein, mxrophin (microf 505
407976 AI633875 Hs 77823 hypothedcal protein FU21343 505
400869 NA 504
416153 R13894 gb yf62a06 r1 Soares infant brain 1NIB H 504
428242 H55709 H Hss 22225500 leukemia inhibitory fxtor (chol ergic 504
406038 Y14443 HHss 8888221199 zinc finger protein 200 503
440659 AF134160 HHss 77332277 claudin 1 503
425188 AK0O2052 Hs 155071 hypothetical protein FU11190 502
446051 BE048061 Hs 37054 ephnn-A3 502
443387 BE139135 Hs 254629 ESTs 502
414407 AA147026 Hs 76704 ESTs 502
408349 BE546947 Hs 44276 homeo box C10 501
452510 Z33566 Hs 301491 ESTs 501
447245 AK001713 Hs 17860 hypothetical protein FU10851 500
413472 BE242870 Hs 75379 solute earner family 1 (glial high affi 500
447857 AA081218 Hs 58608 Homo sapiens cDNA FU 14206 fis, clone NT 500
423648 AK0O0456 Hs 130546 hypothedcal protein FU20449 500
412997 BE046600 gb hn41d08 x1 NCI_CGAP_RDF2 Homo sapiens 500
408964 AF201468 Hs 49349 beta-site APP-cleavmg enzyme 500
411636 AW855001 gb PM3-CT0263-091299-007-K.5 CT0263 Homo 500
418111 R42003 Hs 106513 ESTs 500
402709 NA NA 500
408677 AI279892 Hs 46801 sorting nexin 14 500
411350 AW877011 gb QV2-PT0010-250300-096-b05 PT0010 Homo 500
453382 AA709285 Hs 5997 hypothedcal protein FU 13078 500
458090 AI282149 Hs 56213 ESTs, Highly similar to FXD3 HUMAN FORKH 500
408512 AW902013 Hs 255937 ESTs 500
453240 AI969564 Hs 166254 hypothedcal protein DKFZp566H33 500
440491 R35252 Hs 24944 ESTs, Weakly similar to 2109260A B cell 500
423896 AA332216 Hs 130584 ESTs 500
429091 AA935658 Hs 187939 ESTs 500
410968 AA199907 Hs 67397 homeo box A1 500
436859 AA732681 Hs 270053 i ESTs 500
452198 AI097560 Hs 61210 ESTs, Weakly simila to I38022 hypothed 500
424511 BE300512 Hs 193557 ' ESTs, Moderately similar to ALU7 HUMAN A 500
414631 AW970130 Hs 65406 ESTs 500
405481 NA 500
431118 8E264901 Hs 250502 ! carbonic anhydrase VIII 500
421373 AA808229 Hs 167771 ESTs 500
424916 AW867440 Hs 23096 ESTs 500
433106 AB002443 Hs 18441Ϊ 1 ESTs 500 427386 AW836261 Hs 337717 ESTs 500
441998 AI733236 Hs 128312 ESTs, Weakly similar to ALU1 HUMAN ALU S 500
420161 AI683069 Hs 175319 ESTs 500
430899 BE018217 Hs 183528 hypothetical protein FU 14906 500
415188 BE007531 Hs 258791 ESTs 500
420429 AW293291 Hs 255180 ESTs 500
439038 AV655045 Hs 8366 ESTs 500
457031 AI497955 Hs 304802 ESTs, Weakly similar to KIAA0944 protein 500
430865 AI073424 Hs 5232 HSPC125 protein 500
420583 H77859 Hs 65450 redculon 4 500
432229 AW290976 Hs 143587 ESTs 500
455208 BE180276 gb RC3-HT0622-130400-022-a02 HT0622 Homo 500
419263 AW583874 Hs 89832 insulin 500
452279 AA286844 Hs 61260 hypothedcal protein FU13164 500
419100 AA464362 Hs 6748 hypothedcal protem PP1665 500
438585 AA811371 Hs 123362 ESTs 500
436953 AW959074 Hs 23648 Homo sapiens cDNA FU 13097 fis, clone NT 500
428775 AA434579 Hs 143691 ESTs 500
422471 AA311027 Hs 271894 ESTs, Weakly simila to I38022 hypothed 500
402524 NA 500
TABLE 46B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank xcession numbers
Pkey CAT number Axessions
408248 1049240.1 AW854832AW854798AW854857AW854816 AW854834AW854817
408432 1058667 1 AW195262 R27868AW811262 408744 1078309.1 AW806177AW806178AW265775
409948 116139.1 AA078643 BE535933 AA132607
410424 120166 1 AA084984 Z18302AW502279AW499519
410444 1203699.1 W73484 AW748569 AW748532 AW748585
410498 120611 1 AA355749 AA085520AW966333AA340319BE170936 410784 1221005.1 AW803201 BE079700 BE062940
410979 1228509 1 BE151480 D63282AW812615
411253 1236671.1 AW833897 AW833907 AW833908 AW833920 AW833953 AW833881 AW833878 AW833879 AW833952AW833919AW833921 AW833915
411350 1239976 1 AW877011 AW877066AW877136AW876980 AW991827AW877073AW877070AW882665AW876972AW877068AW877064AW838297 AW877065 AW876974 AW877101 AW877067 AW877127 AW876975 AW876979 AW876983 AW877131 AW877104 411636 1252525.1 AW855001 AW855031 BE062221
411861 1261785.1 AW867875 BE067343 BE067301 BE067350 BE067305 BE067347 BE067306 BE067304 BE067303 BE067302 AW938147
412227 1284297.1 AW902282 AW902508 AW902509 AW902605 AW902606 AW902643 AW902490
412345 1289783.1 AW938386AW938411 AW938426 AW938397
412396 1292796.1 AW947895 AW947891 AW947933 AW947892 AW947930 AW947889 AW947894 AW947931 AW947893 AW947932 AW947929 412997 1343205 1 BE046600 BE046677 BE046236
413604 1379715.1 R51767 BE152515 Z44834 H23397
413894 1397740 1 BE177983 BE178322
414727 1481204.1 BE466904 W28721
415308 1533673 1 F05251 R13748 Z44028 H14747 415371 1535066.1 R15239Z45189 F06836
415397 1535937.1 H10818 F07831 Z43072
415637 1540904 1 R25517 F13222 T75465
416153 1573947.1 R13894 H23037 R56371
416190 1576789.1 N54000H26494 T83818 416845 1624038.1 H95279 H95331 H95933
416913 163001.1 AW934714 BE1610O7 BE162500AW749902AW749864 BE162498 BE161005AA190449AW513465 BE161006 BE162499
417352 166908 1 AA195919 D79180 BE543135 BE008355BE008353 BE008315 BE008317
417588 1688092 1 Z44510 R24958 R0O714T82024
418247 1733290.1 R55174Z19829X97508 418553 1767393 1 T88964 R99447 T84773
418647 177521J AA226198AA226513AA383773
418866 179788 T65754 AA229857 AA229658
423172 225618 1 R15652 AA322742 AW961639 AW961637
423289 226804J N77774AA324125 AW955199 AA452230 423395 227885J AA326613AA325417 AW962164
423928 233416.1 AA332680 AA332831 AW962684
424205 236651.1 AA336825 AA337256 AA337682 AA337525
425757 255956.1 AA363171 AW963347 AA371863
428679 294049.1 AA431765AA432015 430264 315008 1 AA470519 BE303010 BE302954 BE384120
430818 324239.1 AI311928 AA936030 T51931 AA609816AA487195AA664207
432494 348522.1 AA551060AW979274AA847429AA878487
432639 351744.1 AW973785 H60163AA557608
433009 357371.1 AA761668AA573621 R92814 R09670 434006 37855.1 AF113688 AM 14617
434603 38944 1 AF147384 T60126 T60244
436411 419334.1 AW674352AA715374Z25205
437092 432938.1 AA744292 AA745577 AW748517AW748564AW748511 AW748513AW748530 AW748574 BE062923
437237 43506.-2 BE513073 441033 50807.-1 BE562555
441761 525307.1 AI222880 Al 242392 AA961560 AI242524 AI719648 AI718138 AW275807
442075 532052.1 AW136928 AI685655 BE218584 BE465078 N68963 AA975338 BE147199 N76377 445165 63181 AV652831 AA191140 AA329706 AI267893 AI796986 AW675672 AW195369 BE002835 BE003284 AA190592 AA769594 AW275548 R56781 AA807313
AW169695 N31806
447197 7116231 R36075 AI 366546 R36167
453685 9777341 AL110309 AW088119 H22881
454511 12205331 AW948146 AW948135 AW802578
454758 12337431 AW845266 AW845254 AW819440 AW819430 AW819425 AW819423
454835 12365071 AW833763 AW833704 AW833618
455082 12526871 BE148180 AW855210 AW855243
455208 1260551 1 BE180276 AW866156 BE180165
455212 1260678.1 AW866330 AW866410 AW866332 AW866411 AW866327 AW866326 AW866335 AW866334 AW866331 AW866333 AW866328 AW866329
455217 12615221 AW867534 AW867539
455608 1337389.1 BE011437 BE011402 BE011395 BE011428 BE011407 BE011421 BE011406
455847 13753581 BE146775 BE146789 BE146792 BE147010 BE146941 BE146801 BE146998 BE147011 BE146903 BE146901
455944 13855691 BE160643 BE160585
457892 4329261 AA744389 AA744270 AA744284 AA744299 AA745380 AA744337 AA846905 AA847698
457893 4329381 AA744292 AA745577AW748517AW748564 AW748511 AW748513 AW748530 AW748574 BE062923
459279 9756491 AW814996 AL047199 AW850979
TABLE 46C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al * refers to the publicadon endtled The DNA sequence of human chromosome 22* Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposidon Indicates nucleotide positions of predicted exons
Pkey F Ref Strand NLposidon
400484 8569067 Minus 5272552912
400570 9884797 Minus 156787-156862 178082-178208,186819-186957
400639 9887597 Plus 23150-23580
400845 9188605 Plus 34428-34612
400860 9757499 Minus 151830-152104,152649-152744
400869 9838306 Plus 29152-30102
400950 7658481 Minus 157920-158564
400977 8072510 Plus 73950-74364
401004 7229982 Plus 62580-62772
401093 8516137 Minus 2233523166
401183 7670214 Minus 39921-40601
401205 9743388 Plus 167373-167433,167936-168031
401208 7712287 Plus 163145163281
401244 4827300 Minus 55359-56376
401348 9930791 Minus 93659490
401372 9944181 Plus 127056-127196
401424 8176894 Plus 24223-24428
401581 9502454 Plus 9440-10165
401629 8575965 Minus 169335169788
401708 2951946 Plus 154511-155298
401736 3219338 Plus 1771-1894
401740 2982169 Plus 148357-148484,148591-148690
401747 9789672 Minus 118596-118816,119119-119244,119609-119761,120422-120990,130161-130381,130468-130593,131097-131258,131865
131932,132451-132575,133580-134011
401961 4581193 Minus 124054-124209 402343 8099256 Plus 4677-6084 402363 9454515 Plus 25693-25991 402408 9796239 Minus 110326-110491 402524 9798518 Minus 20529-21096 402709 8901246 Minus 56847-57055 402732 9211639 Minus 147904-148107 403040 3133144 Minus 91632-91788,97918-98115 403137 9211494 Minus 92349-92572,92958-93084,93579-93712,93949-94072,94591-94748,95214-95337 403199 9958183 Minus 5889559036,66618-66789 403278 8072597 Plus 146823-146986 403546 8078400 Plus 94703-94849 403764 7717105 Minus 118692-118853 403776 7770611 Minus 1414-1513,1624-1756 403859 7708954 Plus 113738-113858 403973 8575876 Plus 93873-94384 404012 8655948 Plus 551356-552233 404029 7671252 Plus 108715111112 404072 9931705 Plus 49546-50498 404117 9796029 Plus 149723-149920 404170 9930793 Plus 168836-169248 404335 9838027 Minus 21030-2114526504-26692 404440 7528051 Plus 80430-81581 404632 9796668 Plus 4509545229 404702 7630798 Plus 78043-78890 404913 7341740 Plus 97717-97976 404996 6007890 Plus 37999-38145,38652-38998,39727-39872,40557-40674,42351-42450 405033 7107731 Minus 142358-142546 405065 7684500 Minus 1385514027 405114 8096938 Minus 97013-97560 405287 3928029 Plus 89802-89999 405352 2822162 Minus 97253-97742 405362 2337862 Minus 105008-105142,105980-106091,140445140556,142519-142641 405481 3688109 Plus 57155837,8719-8818
405511 9454623 Plus 57731-57852
405523 9454643 Plus 114550-114688,117265117407,119490-119599,123237-123395,131140-131217
405543 9857582 Minus 104335104449
405545 1054740 Plus 118677-118807,119091-119296,121626-121823
405637 6289229 Plus 189852-189978
405696 4309923 Minus 18652013,2124-2231
405770 2735037 Plus 61057-62075
406465 9795550 Plus 94502-94706,9677596914,9879598928,102423-102576,105087-105191,107023-107127,108852-108992
TABLE 47A ABOUT 370 GENES SIGNIFICANTLY DOWN-REGULATED IN STOMACH CANCER COMPARED TO NORMAL STOMACH
Table 47A lists about 370 genes significantly down-regulated in stomxh cancer compaed to normal stomxh These were selxted as for Table 46A, except that the numerator and denominator were switched and the ratio was equal to or less than 033
Pkey Unique Eos probeset idendfier number
ExAxn Exemplar Axession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dtle
R1 Ratio of tumor to normal body dssue
Pkey ExAxn UnigenelD Unigene Title R1
412859 NM 000705 Hs 813 ATPase, H*/K* exchanging, beta polypepd 002
423371 AU076819 Hs 1650 solute earner family 26, member 3 002
425607 U09860 Hs 158333 protease, senne, 7 (enterokinase) 004
429050 X81333 Hs 194777 mepπn A, beta 004
421996 AW583807 Hs 1460 glucagon 005
441212 AW242447 Hs 146182 cytosolic beta-glucosidase 005
429093 NM 000253 Hs 195799 microsomal tπglyceπde transfer protein 006
403697 NA NA 007
402760 NA NA 008
428285 AW340797 Hs 98434 ESTs 008
419279 AA235900 Hs 87500 ESTs 008
422459 K02100 Hs 117050 omithme carba oyltransferase 009
422992 AF016833 Hs 122785 maltase-glucoamylase (alpha-glucosιdase) 009
430867 M16404 Hs 248099 chol ergic receptor, muscaπnic 2 009
453989 M63962 Hs 36992 ATPase, H+/K+ exchanging, alpha polypept 010
443022 AL046485 Hs 207604 ESTs 010
413382 BE090689 gb RC1-BT0720-280300-011-f08 BT0720 Homo 010
450769 AA057418 Hs 33654 ESTs 010
428070 T63918 Hs 182313 rednol-bmding protein 2, cellula 0 10
415447 Z97171 Hs 78454 myxilm, trabxular meshwork inducible 011
430073 U86136 Hs 232070 telomerase-assxiated protein 1 0 11
431716 089053 Hs 268012 fatty-xid-Coenzyme A ligase, long-chan 0 12
416889 AW250318 Hs 80395 mal, T-cell differentiation protein 012
405650 NA NA 0 12
419219 AW583139 Hs 89717 carboxypepddase A2 (pancreatic) 012
401623 NA NA 0 12
400811 AF219139 Hs 87726 KIAA0154 protein, ADP-nbosyladon fxto 0 13
455826 BE144228 gb MRO-HT0165140200-009-d04 HT0165 Homo 013
414949 C15314 Hs 323349 ESTs 013
407486 S69741 gb hSCG-3=stomxh cancer geπe-3 (oncogen 0 13
407494 U10072 gb Human forkhead family (AFX1) mRNA, pa 013
401015 NA NA 0 13
426651 AU076646 Hs 171683 nuclear rxeptor subfamily 1, group H, m 014
450926 AI744361 Hs 205591 ESTs, Weakly similar to T46608 zinc fing 0 14
443564 AI921685 Hs 199713 ESTs 0 14
457955 AI208986 Hs 143945 ESTs 014
457345 AI699933 Hs 192175 ESTs 0 14
417118 U38654 Hs 50477 RAB27A, member RAS oncogene family 0 14
408518 BE162203 Hs 314758 ESTs 014
444938 AW470690 Hs 148814 ESTs 0 15
403670 NA NA 0 15
432440 X63597 Hs 2996 sucrase-isomaltase 0 15
428492 AW662740 Hs 259391 ESTs 0 15
443607 AI452512 Hs 134069 ESTs 0 15
446914 BE044496 Hs 166994 FAT tumor suppressor (Drosophila) homolo 015
424596 AB020639 Hs 151017 estrogen-related rxeptor gamma 0 15
430350 BE169639 gb PM1-HT0527-280200-005a05 HT0527 Homo 016
431094 AW972276 Hs 116195 ESTs 016
401683 NA NA 0 16
419278 AU076799 Hs 1247 apolipoprotein A-IV 016
455071 BE145826 gb MR0-HT0208-101299-2O2-e12 HT0208 Homo 0 16
454282 AW296422 gb UI-H-BWO-aιo-h-05-O-UI s1 NCI_CGAP.Su 0 16
428848 NM 000230 Hs 194236 lepdn (muπne obesity homolog) 016
451729 AW160725 Hs 312469 ESTs 0 16
451103 R52804 Hs 25956 DKFZP564D206 protein 016
428602 AL137479 Hs 186655 Homo sapiens mRNA, cDNA DKFZp434M0223 (f 0 16
437157 BE048860 Hs 120655 ESTs 0 17
422731 AL138411 gb DKFZp434A1229 r1 434 (synonym htes3) 017
402015 NA NA 0 17
414758 H82022 Hs 282847 pregnancy spxific beta-1-glycoproteιn 3 0 17
412793 AW997986 gb RC1-BN0056-230200-021-e11 BN0056 Homo 017
438152 AW292520 Hs 122082 ESTs 0 17 401685 NA NA 0 17
441519 AA972740 Hs 127092 ESTs 0 17
438327 H87407 Hs 172944 choπonic gonadotropin, beta polypepdde 0 17
402761 BE387621 Hs 108809 chaperonin containing TCP1, subunit 7 (e 017
424268 AA397653 Hs 307438 Human DNA sequence from clone 495010 on 0 18
414507 AW102637 Hs 13349 Homo sapiens cDNA FU 14647 fis. clone NT 0 18
413808 J00287 Hs 182183 Homo sapiens mRNA for caldesmon, 3 UTR 018
401132 NA NA 0 18
412374 X01388 Hs 73849 apolipoprotein C-lll 0 18
423417 AP000365 Hs 128342 potassium large conductance calcium-xd 018
447677 AI419235 gb tf21d02 x1 NCI_CGAP.Brn23 Homo sapien 018
448828 AI580296 Hs 174782 ESTs, WeakJy similar to WAA1437 protein 0 18
424122 AA335593 Hs 116147 ESTs 0 18
417332 AW972717 Hs 288462 hypothedcal protein FU21511 018
434597 AW974668 gb EST386757 MAGE resequences, MAGM Homo 0 19
428804 AKO0O713 Hs 193736 hypothedcal protein FU20706 0 19
410280 AA083558 Hs 261286 ESTs 019
409382 AA071244 gb zm73g03 r1 Stratagene πeuroepithelium 019
428062 AA420683 Hs 98321 hypothetical protein FU14103 0 19
426069 H10807 Hs 281434 Homo sapiens cDNA FU14028 fis, clone HE 019
430135 NM 000035 Hs 234234 akfolase B, fructose-bisphosphate 019
414802 AI793107 Hs 27018 Ris 0 19
457432 NM.005136 Hs 268538 potassium
Figure imgf000505_0001
Isk-rel 019
446909 AA004895 Hs 30082 ESTs 019
435447 AI872932 gbwm72e03 x1 NCI_CGAP_Ut2 Homo sapiens 020
408611 NM 004367 Hs 46468 chemokine (C-C modf) receptor 6 020
423577 AW810107 Hs 58633 Homo sapiens cDNA FU22145 fis, clone H 020
439328 W07411 Hs 118212 ESTs, Moderately similar to ALU3 HUMAN A 0 20
436741 AA860163 Hs 291319 ESTs 020
426635 BE395109 Hs 129327 hypothetical protein MGC13057 020
418277 AW135221 Hs 130812 ESTs 0 20
448871 BE616709 Hs 159265 kruppel-related zinc finger protein hcKr 020
459370 AA889982 Hs 271826 ESTs, Weakly similar to I38022 hypothed 021
427469 AA403084 Hs 269347 ESTs Weakly simila to 2109260A B cell 021
432887 AI926047 Hs 162859 ESTs 021
421296 NM 002666 Hs 103253 penlipm 021
449216 AW295417 Hs 224616 ESTs 0 21
414835 AA156720 Hs 185342 ESTs 021
459233 AI939966 gb MRO-CT0015160799-002-M.6 CT0015 Homo 0 21
439756 AL359651 Hs 283852 Homo sapiens mRNA full length insert cDN 021
427167 AI239607 Hs 99196 hypothetical protein MGC11324 021
400410 AF154915 Hs 283958 homeo box D12 0 21
409828 AW501137 gb Ul HF-BPOp-aιt-e-12-O-UI r1 NIH.MGC.5 022
428470 AC002301 Hs 184507 Homo sapiens Chromosome 16 BAC clone CIT 022
455968 BE168828 gb QV1-HT0517-020400-145«M HT0517 Homo 022
404145 NA NA 0 22
454011 M31008 Hs 37009 alkaline phosphatase, intesdnal 0 22
430588 AI741461 Hs 161904 ESTs 022
403652 NA NA 0 22
440410 AW204436 Hs 128715 ESTs 022
453871 BE300380 Hs 69476 Homo sapiens cDNA FLJ12758 fis, clone NT 022
458567 AI222075 Hs 147831 ESTs 0 22
436004 AA703332 Hs 196270 folate transporter/earner 022
417408 F17211 Hs 86092 Homo sapiens skeletal myosin light chain 022
448643 AI557531 gb pt2 1-06 D06 r tumor2 Homo sapiens cD 022
404401 NA NA 022
428088 AA421130 Hs 112640 EST 022
427074 AA527435 Hs 178589 hepatocellular carcinoma antigen gene 52 022
421972 M18185 Hs 1454 gastπc inhibitory polypeptide 022
429001 AF098951 Hs 194720 ATP-bindmg cassette, sub-family G (WHIT 0 22
441155 AW161008 Hs 7719 GABA(A) receptor-assxiated protein 022
402750 NA NA 0 22
438587 AA811450 Hs 136984 ESTs 022
404848 NA NA 022
427833 AA416615 Hs 98242 ESTs 0 23
439907 AA853978 Hs 124577 ESTs 023
414373 AW162907 Hs 75969 proline-πch protein with nuclear taget 0 23
446817 AI700684 Hs 134166 ESTs 023
437333 AA748898 gb ny76h10s1 NCI CGAP GCB1 Homo sapiens 023
404097 NA NA 0 23
446393 AW014174 Hs 301956 zinc finger protein 023
456328 T41368 gb ph1d1 19/1TV Outward Alu-pπmed hncDN 0 23
401042 NA NA 023
458441 AW842283 Hs 79933 cyclm 1 023
435547 AW117431 Hs 191906 ESTs 023
429060 AW139155 Hs 194995 hypothedcal protein DKFZp434O0320 023
425158 AW954631 Hs 266940 t-complex-assxiated-testis-expressed 1- 023
448758 AB018311 Hs 21917 KIAA0768 protein 023
441240 AA923749 Hs 132442 ESTs 023
436562 H71937 Hs 322904 ESTs, Weakly simila to I38022 hypotheti 0 23
424104 AA669515 Hs 144950 ESTs 023
447452 BE618258 Hs 102480 Homo sapiens, ctone IMAGE 3869590 mRNA, 023
444515 AW204908 Hs 169979 ESTs 0 24 433084 M18079 Hs 282265 fatty xid binding protein 2, intesdnal 024
406560 NA NA 024
432408 N39127 Hs 332557 ESTs, Weakly similar to A46010 X-lmked 0 24
455699 BE068121 gb CM1 BT0368-061299-060-a02 BT0368 Homo 024
453979 M68895 Hs 76800 alcohol dehydrogenase 6 (class V) 0 24
439657 W93589 gb zd95g05 s1 Soares_fetal_heart_NbHH19W 024
407512 X15674 gb Human pTR5 mRNA for repeddve sequen 024
440875 AW138036 Hs 201788 ESTs 024
404753 NA NA 0 24
411119 M60627 Hs753 formyl peptide rxeptor 1 024
418692 AK000268 Hs 87383 hypothetical protem 024
415327 H22769 gb ym54c02 r1 Soares infant bran 1 NIB H 024
429446 AI547111 gb PN2 1.A01_G12 r mynorni Homo sapiens c 024
455391 BE156230 gb QVO-HT0367-310100-102-C11 HT0367 Homo 025
422818 AA404290 Hs 97848 ESTs 025
435338 AA678071 Hs 194300 ESTs, Weakly similar to 138022 hypothed 025
414203 BE262170 Hs 78629 ATPase, Na K* transporting, beta 1 poly 025
403941 NA NA 025
414383 BE279406 gb 601157981F1 NIH_MGC_21 Homo sapiens c 025
412008 NM 001841 Hs 73037 cannabinoid receptor 2 (mxrophage) 025
424985 AI907236 Hs 279935 Homo sapiens cDNA FU 11780 fis, clone HE 025
450736 AW970060 gb EST382140 MAGE resequences, MAGK Homo 025
431185 H02767 Hs 28944 ESTs 025
455308 AW893949 gb RC4-NN0027-O60400-011-a09 NN0027 Homo 025
435464 BE548300 Hs 192999 ESTs, Moderately similar to KIAA0961 pro 025
418525 AW450369 Hs 86937 ESTs 025
402790 NA 025
411869 W20027 Hs 23439 ESTs 025
400332 S66407 Hs 248032 FLT4 025
424884 AW299437 Hs 225717 ESTs 025
414376 BE393856 Hs 66915 ESTs, Weakly similar to 167Kd protein [ 025
439780 AL109688 gb Homo sapiens mRNA full length insert 025
408947 AL080093 Hs 49117 Homo sapiens mRNA, cDNA DKFZp564N1662 (f 025
404900 NA NA 025
441918 AI733373 Hs 128119 ESTs 025
441639 AI133287 Hs 303953 ESTs 025
459396 AI907536 Hs 103869 ESTs 025
452755 AW138937 Hs 213436 ESTs, Weakly similar to A34087 hypothed 025
422183 AA431698 Hs 112794 Human DNA sequence from clone 1068E13 on 025
415186 AA160945 Hs 14479 Homo sapiens cDNA FU14199 fis, clone NT 026
429450 AA824451 Hs 94292 hypothetical protein FU23311 026
455615 BE045344 Hs 274923 ESTs, Moderately similar to unnamed prot 026
454633 AW811380 gb IL3-ST0143-290999-019-D05 ST0143 Homo 026
424853 BE549737 Hs 132967 Human EST clone 122887 manner transposo 026
455802 BE141491 gb MRO-HT0080-011099-002-h06 HT0080 Homo 026
414003 AA134472 gb zo13c01 s1 Stratagene ∞lon (937204) 026
436363 AA843926 Hs 124434 ESTs 026
456074 BE409525 Hs902 neurofibromin 2 (bilateral xoustic neur 026
430569 AF241254 Hs 178098 angiotensm I converting enzyme (pepddy 026
445635 AI769774 Hs 209831 ESTs, Weakly simila to ALU1_HUMAN ALU S 026
405953 NA NA 026
411021 F00055 Hs 172004 ddn 026
428443 BE618106 Hs 184326 CDC10 (cell division cycle 10, S cerevi 026
434345 AF127772 gb Homo sapiens cell line E8CASS clone E 026
455743 BE073754 gb RCO-BT0561-210100-032-d07 BT0561 Homo 026
451138 W92287 Hs 40268 ESTs 026
449528 H63337 Hs 38178 hypothetical protein FLJ23468 026
441040 AW449782 Hs 178803 ESTs 026
458830 AW501248 Hs250824 Homo sapiens cDNA FU23435 fis, clone H 026
428861 AW352234 Hs 269365 ESTs, Weakly similar to ALU8_HUMAN ALU S 026
435469 AW388237 Hs 191204 ESTs 027
427562 R56424 Hs 26534 ESTs 027
434779 AF153815 Hs 50151 potassium inwardly-recdfying channel, s 027
423528 AB011137 Hs 300938 KIAA0565 gene product 027
406589 NA 027
450059 BE220223 Hs 279626 ESTs 027
417296 L36196 Hs 81884 sulfotransferase family, cytosolic 2A, 027
454007 AW015870 Hs 232081 ESTs 027
426062 N57014 Hs 75874 pregnancy-assxiated plasma protein A 027
441665 AI301355 Hs 151285 ESTs 0 27
405037 NA NA 027
446820 AW295037 Hs 254986 ESTs 027
448487 AI523720 Hs 172567 ESTs 0 27
447567 AW474513 Hs 224397 ESTs, Weakly similar to 138931 Wiskort-A 027
408540 L13220 Hs639 caibindin 3, (vitamin D-dependent calciu 027
407601 AC002300 Hs 37129 sodium channel, noπvollage-gated 1 , beta 027
432501 BE546532 Hs 25682 Homo sapiens mRNA for KIAA1863 protein, 027
401350 NA NA 027
417569 R00271 Hs 144651 ESTs 027
443542 AI927065 Hs 146040 ESTs 027
437105 AA744554 Hs 222127 ESTs 027
432119 T80289 Hs 302041 Homo sapiens clone 24762 mRNA sequence 027
419056 M89957 Hs 89575 CD79B antigen (immuπoglobulin-assxiated 028 427812 AA770424 Hs 98162 ESTs 028
423557 AB011176 Hs 129801 KIAA0604 gene product 028
445311 AW027556 Hs 156286 ESTs 028
402758 NA NA 028
448240 AI478345 Hs 191034 ESTs 028
401333 NA NA 028
444107 T46839 Hs 10319 UDP glycosyltransferase 2 family, polype 028
454738 BE072139 gb PM 1 -BT0533-291299-002-b05 BT0533 Homo 028
442896 R37725 Hs 261108 ESTs 028
447949 AI446820 Hs 165839 EST 028
435625 H50654 Hs 113999 ESTs 028
415817 U88967 Hs 78867 protein tyrosine phosphatase, receptor-t 028
438380 T06430 Hs 6194 chondroidn sulfate proteoglycan BEHAB/b 028
442967 AI025460 Hs 220977 ESTs 028
448062 AW295923 Hs 255472 KIAA1843 protein 028
425860 L29339 Hs 1964 solute earner family 5 (sodium/glucose 028
451839 AI820516 Hs 16857 ESTs 028
446000 AV656052 Hs 1504 hemopexm 028
443506 H10661 Hs 192124 ESTs, Weakly similar to I38022 hypothed 028
418345 AJ001696 Hs 241407 senne (or cysteine) proteinase inhibito 028
445481 AW661846 Hs 148836 ESTs 028
409337 H71289 Hs 220535 ESTs 028
411414 AW897236 gb CMO-NN0057-150400-335-C06 NN0057 Homo 028
427642 R40761 Hs 9834 ESTs 028
456392 W28766 gb 51d3 Human retina cDNA randomly pπme 028
409920 BE169746 Hs 12504 likely ortholog of mouse Arkadia 028
410285 AA083609 gb zm63d05 r1 Stratagene fibroblast (937 028
442496 R55073 Hs 124130 ESTs 028
423770 AW976766 Hs 132776 Homo sapiens cDNA FU10077 (is, clone HE 028
423467 AK000214 Hs 129014 hypothedcal protein FU20207 029
458716 N99013 Hs 16762 Homo sapiens mRNA cDNA DKFZp564B2062 (f 029
423235 AW410698 Hs 169917 neurabin II 029
431087 H12723 Hs 290791 ESTs 029
459106 AW589793 Hs 224713 ESTs 029
414870 N72264 Hs 300670 KIAA1204 protein 029
402243 NA 029
432628 R02394 Hs 269436 ESTs, Moderately similar to PC4259 fern 029
404364 NA NA 029
400480 NA 029
456083 U46922 Hs 77252 fragile histidine toad gene 029
446598 AW250546 gb 28217745pnme NIH_MGC_7 Homo sapiens 029
422201 NM 001505 Hs 113207 G protein-coupled rxeptor 30 029
443919 AI091284 Hs 135224 ESTs Weakly similar to A47582 B-cell gr 029
453948 AI970797 Hs 64859 ESTs 029
403792 NA NA 029
418957 AI792615 Hs 188712 ESTs 029
457960 AA771881 Hs 298149 ESTs 029
404269 NA 029
439309 AF090097 Hs 6524 Homo sapiens clone IMAGE 25997 029
458239 BE439877 Hs 283389 ESTs 030
414941 C14865 Hs 332341 ESTs 030
404954 NA 030
441609 AA946764 Hs 133460 ESTs 030
426895 AA416880 Hs 225738 ESTs 030
403182 NA NA 030
402319 NA 030
429699 AI383469 Hs 159300 ESTs 030
405669 NA NA 030
459312 AF107457 Hs 37035 hom∞ box HB9 030
431853 AA521034 Hs 70834 ESTs 030
449768 AI972746 Hs 102945 ESTs, Weakly similar to I78885 senne/th 030
443609 AV650231 Hs 282941 ESTs. Highly similar to A Cham A, Human 030
454293 H49739 Hs 134013 ESTs, Moderately similar to HK61_HUMAN H 030
447569 AI393202 Hs 147554 hypothedcal protein FU23392 030
400128 NA NA 030
423208 AA323191 Hs 137064 cytoplasmic polyadenylation element bind 030
434227 AF119893 Hs 63382 hypothedcal protein PR02714 030
424208 AW583123 Hs 143113 pancreadc lipase-related protein 2 030
401165 NA NA 030
415394 R19249 Hs 22654 sodium channel, voltage-gated, type I, a 030
443110 AW352243 Hs 132665 ESTs 030
426724 AA383623 Hs 293616 ESTs 030
416035 H42314 gb yo09e02 s1 Soaes adult bran N2b5HB5 030
409753 AA234847 gb zs37b10 r1 Soares.NhHMPu_S1 Homo sapi 031
459221 BE246522 Hs 306121 leukxyte receptor cluster (LRC) encoded 031
408895 AA058730 Hs 191464 ESTs 031
405110 NA NA 031
432430 AW079984 Hs 262480 ESTs, Weakly similar to PIHUB6 salivary 031
426442 AA378656 Hs 106510 ESTs. Moderately similar to ALU2_HUMAN A 031
411765 H43346 gb yp09a04 r1 Soares breast 3NbHBst Homo 031
431854 AA383550 Hs 271699 polymerase (DNA dirxted) iota 031
457553 AI861896 Hs 304505 ESTs 031
412301 AW936328 gb QV4-DT0021-281299-070-f07 DT0021 Homo 031 418626 AW299508 Hs 135230 ESTs 031
416156 Z41922 gb HSC03B101 normalized infant brain cDN 031
416275 H42823 Hs 155742 glyoxylate reductase/hydroxypyruvate red 031
419091 T85332 Hs 178294 ESTs 031
420118 AW295297 Hs 182585 KIAA1276 protein 031
451094 AI949825 Hs 260395 ESTs 031
403214 NA NA 031
412717 W00973 Hs 334728 ESTs 031
428782 X12830 Hs 193400 interieukin 6 receptor 031
449202 AW295154 Hs 255396 ESTs 031
433138 AB029496 Hs 59729 semaphoπn sem2 031
436602 AI793222 Hs 166817 ESTs 031
424844 D61524 gb HUM413E07B Clontech human fetal bran 032
435253 W91884 gb zh47f08 s1 Soares fetal liver spleen 032
455350 AW901809 gb QVO-NN1020-1704bθ-195h02 NN10M Homo 032
416320 H47867 Hs 34024 ESTs 032
406333 NA 032
443652 AI080692 Hs 134229 ESTs, Weakly simila to 154401 hypertens 032
457103 AI421187 Hs 189192 ESTs, Weakly similar to T COMPLEX TESTIS 032
423593 AA328144 gb EST31752 Embryo, 12 week I Homo sapie 032
453242 T98327 Hs 18343 ESTs 032
456281 AA284166 Hs 84113 cyclin-dependent kinase inhibitor 3 (CDK 032
403847 NA NA 032
458711 AL036877 Hs 282878 ESTs 032
406242 NA NA 032
433493 AA594915 Hs 155087 ESTs 032
458147 AW752597 gb IL3-CT0214-161299-O45BO5 CT0214 Homo 032
437403 AI208149 Hs 121196 ESTs 032
407823 D44744 Hs 247447 ESTs 032
457300 AW297436 Hs 158849 Homo sapiens cDNA FU21663 fis, clone C 0 32
436089 AA804957 Hs 119840 ESTs 032
457463 AW877031 Hs 272321 hypothedcal protein FU12571 032
433370 AI084343 Hs 122310 ESTs 032
436298 AW293496 Hs 180138 ESTs 032
419768 T72104 Hs 93194 apolipoprotein A-l 033
449428 AI651280 Hs 195685 ESTs 033
406291 NA NA 033
409699 BE154650 gb PM3-HT0344-071299 03-C08 HT0344 Homo 033
418162 T11958 gb A802R Heart Homo sapiens cDNA clone A 033
408316 AW807771 gb MR4-ST0098-090300-003-C05 ST0098 Homo 033
404187 NA NA 033
452992 AI792376 Hs 31290 Homo sapiens clone 23832 mRNA sequence 033
448355 AI493734 Hs 329374 ESTs 033
442423 BE326264 Hs 246842 ESTs 033
439474 AI824060 Hs 211501 ESTs 033
457149 AA429575 Hs 297493 ESTs 0 33
448623 BE613468 Hs 107515 ESTs, Weakly simila to T00329 hypothed 033
454790 AW820852 gb RC2-ST0301-120200-011-f12 ST0301 Homo 033
419372 W28781 gb 51h3 Human redna cDNA randomly pnme 033
406293 NA NA 033
422933 AF073931 Hs 122359 calcium channel, voltage-dependent, alph 033
451818 AI819018 Hs 339668 ESTs 033
441912 AA971484 Hs 159938 ESTs 0 3
429013 AJ012590 Hs 194728 hexose-5phosphate dehydrogenase (glucos 033
422304 AK002016 Hs 114727 Homo sapiens, clone MGC 16327, mRNA, com 033
457394 M86528 Hs 266902 neurotrophin 5 (neurotrophin 4/5) 033
406597 NA 033
451636 AW173270 Hs 140444 ESTs 033
424226 N94153 Hs 19155 ESTs 033
TABLE 47B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accessior i Genbank xcession numbers
Pkey CAT Number Axession
408316 1051210 1 AW807771 AW179260 AW807851 AW179240 AW845961 AW807693 BE141176 /
409382 112508.1 AA071244 AA071477
409699 1149033 1 BE154650 BE154785 AW468343 BE154816 BE154667
409753 115305 1 AA234847 AA077472
409828 1155571J AW501137 AW501295 AW501212
410285 119128 1 AA083609 AA083790 AA112048
411414 1245024 1 AW897236 AW845406
411765 125700 1 H43346 AA248302 AA095182
412301 1288123 1 AW936328 AW936539
412793 1327636.-1 AW997986
413382 1365954 1 BE090689 BE090685 BE090697 BE090680 BE090691 BE090696 BE090698 BE0
414003 140888 1 AA134472 R76288 AW750262
414383 1440279 1 BE279406 BE280100
415327 1534137.1 H22769 R35182 Z43545 F05783 N92089 H71928
416035 1567254 1 H42314 H43080 H45217 H15384
416156 1573980.1 Z41922 H23072 T77322
418162 1725383.1 T11958 T11756 T11816 T20135 T19729 R45874 419372 1842942.1 W28781 W26588 W26377 422731 220507.1 AL138411 AL138412 AA315860 423593 229955.1 AA328144 AW962385 N30457 424844 244291 1 D61524 AA347654 AW961758 429446 304683.1 AI547111 AW973749 AA558007 430350 316401 1 BE169639 AA476976 434345 38411 _ϊ AF127772 AF062358 AF060217 AA652270 F23288 434597 389383 1 AW974668 AA661959 AA649572 AA640401 AA640402 435253 403478.1 W91884 W95119AA676941 435447 406400.1 AI872932 AA682306 BE220163 W88695 T81307 H91447 437333 436167.1 AA748898 AW997701 AW997703 439657 47499.1 W93589W93487AF086493 439780 47673.1 AL109688 R23665 R26578 446598 68463 1 AW250546 BE257108 BE251006 BE255957 BE250926 BE513012 AV659318 447677 732252.1 AI419235 AW0550168E007490 BE550241 448643 773566.-1 AI557531 450736 844652 1 AW970060 AI732366 AI792313AW839644 454282 1091035.1 AW296422 H72616 H63825 454633 1227504.1 AW811380 AW811385 454738 1232449.1 BE072139 BE157977 BE157974 AW857974 AW817778 454790 1234752.1 AW820852 AW820773 AW821088 455071 1252281.1 BE145826 BE145815 BE145822 AW854707 BE145912 455308 1278147.1 AW893949AW893960 AW893966 455350 1283853.1 AW901809 AW901787 AW901795 AW901792 AW901744 AW901753 AW901807 AW901798 455391 1288067.1 BE156230 BE156239AW936260 455699 1351258.1 BE068121 BE068090 BE068153 BE068128 BE068197 BE068136 BE068140 BE068185 BE068105 455743 1354978.1 BE073754 BE073753 BE073755 BE073756 BE073752 BE073795 BE073796 BE073704 BE073791 BE073733 BE073695 455802 1370828.1 BE141491 BE141016 BE141479 455826 1373392.1 BE144228 BE144291 455968 1391117.1 BE168828 BE168830 BE168823 BE168928 BE168820 BE168826 456328 1789791.1 T41368 T41369 T41294 456392 1843059.1 W28766 W26500 458147 488021.1 AW752597 AW848781 AW849062 AW848490 AW752699 AW752604 AW752700 459233 944881.1 AI939966 AI939988 AI939951 AI939981 AI939976 AI939959
TABLE 47C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publicadon endded The ONA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposidon Indicates nucleotide positions of predicted exons
Pkey Ref Strand NLposidon
400480 8439796 Minus 110553-111119
401015 8117441 Plus 72260-72369
401042 8117611 Plus 151364-151606
401132 8705350 Minus 85679-85795
401165 9438376 Minus 168244-168423
401333 9884881 Plus 13852-14861
401350 9931226 Plus 14471-14623
401623 8575907 Plus 163249-163623
401683 7689961 Plus 2934-3446
401685 7689961 Minus 8038-8319
402015 7417802 Minus 48791-49043,5003550205,51530-51672,54448-54565,55933-56073
402243 7690137 Minus 196521-196721
402319 7582559 Plus 116589-117549
402750 7210067 Plus 6946569678,71139-71284,71572-71865
402758 9213869 Plus 8763587924
402760 9213869 Plus 136829-136952,137335137521
402790 4835258 Minus 147744-147861
403182 9838273 Plus 102163-102345,102545102725
403214 7630945 Minus 76723-77027,79317-79484
403652 8705848 Minus 49991-50129
403670 7259739 Minus 88377-88537
403697 3962501 Minus 102965103174
403792 7230192 Minus 149707-149873
403847 7708844 Plus 317240-317391,317915318032
403941 7454203 Plus 114875115342
404097 7770701 Plus 55512-55781
404145 9863643 Plus 30607-31266
404187 4481839 Plus 7644-7991
404269 9711443 Plus 70261-70404,72944-73063
404364 9964977 Minus 3298533202
404401 7259738 Plus 7106571326
404753 7637341 Plus 14770-14931
404848 8248647 Minus 2395524034,25143-25264
404900 7331453 Plus 22032-22219
404954 7387327 Plus 131720-132042
405037 7543748 Minus 127374-127578
405110 8096888 Minus 118940-119100
405650 4926905 Minus 71743-72291
405669 4508140 Plus 14130-14270
405953 7960374 Minus 65101-65574 406242 7417725 Minus 3673536951
406291 5686274 Plus 9562 9867
406293 5686274 Minus 1764617953
406333 9213235 Plus 64689-64798
406560 7711569 Minus 35162-35292
406589 8224211 Plus 3880538989
406597 8248613 Minus 132735132985,134265134425,135034-135192,135471-135608,137345137478,138765138912
TABLE 48A ABOUT 426 GENES UPREGULATED IN MELANOMA RELATIVE TO NORMAL BODY TISSUES
Table 48A lists about 426 genes upregulated in melanoma relative to normal body dssues These genes were selxted from 59680 probesets on Ihe Eos/Affymetπx Hu03 Genxhip array Gene expression data for exh probeset obtaned from this analysis was expressed as average intensity (Al), a normalized value reflxdng the reladve level of mRNA expression
Pkey Unique Eos probeset idendfier number
ExAxn Exemplar Axession number, Genbank accession number
UnigenelD 1 Unigi =ne number
Unigene Tide Unigene gene dde
R1 Mean of melanoma Als divided by the mean of no ial dssue Als, where the minimum
Pkey ExAxn UnigenelD Unigene Title R1
426555 NM 000372 Hs 2053 tyrosinase (xulocutaneous albinism IA) 37661
428655 H05769 Hs 188757 Homo sapiens, ctone MGC 5564, mRNA, comp 32436
430377 NM 001922 Hs 301865 dopxhrome tautomerase (dopxhrome delta 231 30
453344 8E349075 Hs 44571 ESTs 18067
425289 AW139342 Hs 155530 interferon, gamma-inducible protein 16 107 36
417166 AA431323 Hs 42146 ESTs 97 76
425234 AW152225 Hs 165909 ESTs, Weakly simila to I38022 hypothed 9676
434826 AF155661 Hs 22265 pyruvate dehydrogenase phosphatase 9452
427528 AU077143 Hs 179565 minichromosome mamteπaxe deficient (S 9088
438209 AL120659 HS 6111 aryl-hydrocabon receptor nuclear fransl 8791
443983 H04482 Hs 163724 ESTs 8555
428513 BE220806 Hs 184697 Homo sapiens clone 23785 mRNA sequence 8503
419956 AL137939 Hs 40096 cadhenn 19, type 2 8427
423605 AF047826 Hs 129887 cadheπn 19, type 2 8088
430540 AW245422 Homo sapiens cDNA FU22105 fis, clone H 8064
416975 NM 004131 Hs 1051 granzyme 8 (granzyme 2, cytotoxic T-lymp 7909
421633 AF121860 Hs 106260 sorting nexin 10 71 52
442064 AI422867 Hs 88594 ESTs 6988
418310 AA814100 Hs 86693 ESTs 6794
423799 AW026300 Hs 132906 19A24 protein 6764
432886 BE159028 Hs 279704 chromadn accessibility complex 1 63 24
456508 AA502764 Hs 123469 ESTs, Weakly similar to AF208855 1 BM-01 63 18
432882 NM 013257 Hs 279696 senjm/glucocorticoid regulated kinase-h 62 33
454088 AW062425 gb CM0-CT0042-O90899-018-.O1 CT0042 Homo 61 62
430838 N46664 Hs 169395 hypothedcal protein FU12015 60 52
422363 T55979 Hs 115474 replicadon fxtor C (xdvator 1) 3 (38 5973
407748 AL079409 Hs 38176 KIAA0606 protein, SCN Orcadian Oxillat 5933
450800 BE395161 HS 1390 proteasome (prosome, mxropan) subunit, 5900
441224 AU076964 Hs 7753 calumenin 5827
408418 AW963897 Hs 44743 KIAA1435 protem 5679
428001 H97428 Hs 219907 ESTs, Moderately similar to Transforming 5645
456373 BE247706 Hs 89751 membrane-spanning 4-domaιns, subfamily A 56 29
420674 NM 000055 Hs 1327 butyrylcholinesterase 56 15
407856 AA045281 Hs 266175 phosphoprotein assxiated with GEMs 5582
420552 AK0O0492 Hs 98806 hypothedcal protein 5539
442355 AA456539 Hs 8262 lysosomal-assxiated membrane protein 2 5497
429747 M87507 Hs 2490 caspase 1, apoptosis-relaled cysteine pr 5285
410174 AA306007 Hs 59461 OKFZP434C245 protein 5200
437396 BE140396 Hs 21621 hypothedcal protein DKFZp762O076 51 97
409557 BE182896 Hs 3686 ESTs 51 64
420301 AA767526 Hs 22030 paired box gene 5 (B-cell lineage spxif 51 42
414403 A 969551 Hs 76064 nbosomal protein L27a 5058
452958 AA883929 Hs 40527 ESTs 50 21
458997 AW937420 ESTs 4997
458079 AI796870 Hs 54277 DNA segment on chromosome X (unique) 992 4985
435905 AW997484 Hs 5003 KIAA0456 protein 4876
424800 AL035588 Hs 153203 MyoO family inhibitor 4833
426827 AW067805 Hs 172665 methylenetetrahydrofolate dehydrogenase 4791
408548 AA055449 Hs 63187 ESTs, Weakly simila to ALUC.HUMAN "« 4745
420000 AB036063 Hs 94262 p53-ιnducιble nbonucleodde reductase s 4652
419485 AA489023 Hs 99807 ESTs, Weakly similar to unnamed protein 45 79
451134 AA318315 Hs 25999 hypothedcal protein FU22195 4552
430066 AI929659 Hs 237825 signal recognition particle 72kD 4545
417427 M90391 Hs 82127 interieukin 16 (lymphxyte chemoattrxta 4458
450447 AF212223 Hs 25010 hypothedcal protein P152 4336
446019 AI362520 histone dexetylase 3 4303
430015 AW768399 ESTs 4245
446860 AI811807 Hs 108646 Homo sapiens cDNA FU14934 fis. clone PL 42 36
409327 L41162 Hs 53563 collagen, type IX, alpha 3 42 30
425390 AI092634 Hs 156114 protein tyrosine phosphatase, non-rxept 41 42
411088 BE247593 Hs 145053 ESTs 41 21
408527 AL135018 Hs 33074 Homo sapiens, clone IMAGE 3606519, mRNA, 4094
441590 AI623207 Hs 190537 ESTs 4066 457465 AW301344 Hs 122908 DNA replicadon fxtor 3991
430280 AA361258 Hs 237868 interieukin 7 rxeptor 3891
410700 AA352335 Hs 65641 hypothetical protein FLJ 20073 3870
421282 AA286914 Hs 40782 ESTs 3855
448275 BE514434 Hs 20830 kinesm-like 2 3800
453912 AL121031 SWI/SNF related, matnx assxiated. xd 3794
414844 AA296874 Hs 77494 deoxyguanosme kinase 3788
421305 BE397354 Hs 324830 dipthena toxin resistance protein requi 3770
439352 BE614347 Hs 169615 hypothedcal protein FU 20989 3764
409078 AW327515 ESTs 37 30
449845 AW971183 Hs 6019 DnaJ (Hsp40) homolog, subfamily C, membe 3727
444184 T87841 Hs 282990 Human DNA sequence from clone RP1-28H20 3721
445819 AI767472 Hs 146290 ESTs, Weakly simila to putadve p150 [H 37 21
451418 BE387790 Hs 26369 hypothedcal protein FU20287 3700
433226 AW503733 Hs 9414 KIAA1488 protein 3688
445784 AI253155 Hs 146065 ESTs 3536
454117 BE410100 Hs 40368 adaptor-related protein complex 1, sigma 3309
407756 AA116021 Hs 38260 ubiquidn spxific protease 18 3205
447937 AL109716 Hs 20034 Homo sapiens mRNA full length insert cDN 31 00
438549 BE386801 Hs 21858 tπnudeotide repeat containing 3 3076
429083 Y09397 Hs 227817 BCL2-related protein A1 3073
444670 H58373 Hs 332938 hypothedcal protein MGC5370 2845
446839 BE091926 Hs 16244 mitodc spindle coiled-coil related prot 2762
433576 BE080715 Hs 161091 ESTs 2742
422173 BE385828 Hs 250619 phorbolm-like protein MDS019 (CEM15) 2736
408962 BE386436 Hs 44317 SRY (sex determining region Y)-box 10 2666
442757 AI739528 Hs 28345 ESTs 2594
414646 AA353776 Hs 901 CD48 andgen (B-cell membrane protein) 2539
433675 AW977653 Hs 75319 nbonucleodde reductase M2 polypeptide 2455
438461 AW075485 Hs 286049 phosphoseπne aminotransferase 2248
427581 NM 014788 Hs 179703 KIAA0129 gene product 22 15
435256 AF193766 Hs 13872 cytokine-like protein C17 2061
409988 N27687 Hs 334334 transcnpdon fxtor AP-2 alpha (xdvat 1979
444863 AW384082 Hs 104879 senne (or cysteme) proteinase inhibito 1973
417404 NM 007350 Hs 82101 plxkstnn homology-like domain, family 1927
458098 BE550224 metallothionein 1E (functional) 1809
417018 M16038 Hs 80887 v-yes-1 Yamaguchi sacoma viral related 1695
446054 AB014537 Hs 13604 KIAA0637 gene product 1567
432606 NM 002104 Hs 3066 granzyme K (senne protease, granzyme 3, 1554
414696 AF002020 Hs 76918 Niemann-Pick disease, type C1 1506
457211 AW972565 Hs 32399 ESTs, Weakly similar to S51797 vasodilat 1489
414821 M63835 Hs 77424 Fc fragment of IgG, high affinity la, re 1484
422486 BE514492 Hs 117487 gene nea HD on 4p163 with homology to 1461
424308 AW975531 Hs 154443 minichromosome maintenance deficient (S 14 12
421334 BE297729 gb 601175625F1 NIH_MGC_17 Homo sapiens c 1394
422423 AF283777 Hs 116481 CD72 andgen 1377
408996 AI979168 Hs 344096 glycoprotein (transmembrane) nmb 13 33
416406 D86961 Hs 79299 hpoma HMGIC fusion partner-like 2 1276
427536 BE277141 Hs 115803 gb 601178666F1 NIH_MGC_20 Homo sapiens c 1276
423198 M81933 Hs 1634 cell division cycle 25A 1266
430770 AA765694 Hs 123296 ESTs 1258
407833 AW955632 Hs 66666 ESTs Weakly similar to S19560 prolme-r 1209
430822 AJ005371 Hs 248017 glyceraldehyde-3-phosph ate dehydrogenase 11 46
424259 AK001776 Hs 143954 hypothedcal protein FU10914 1058
446950 AA305800 Hs 5672 hypothetical protein AF140225 1004
420956 AA351584 Hs 100543 Homo sapiens clone 24505 mRNA sequence 998
448356 AL120837 Hs 20993 high-glucose-regulated protein 8 988
428799 AI478619 Hs 104677 ESTs 956
437271 AL137445 Hs 28846 Homo sapiens mRNA cDNA DKFZp5660134 (fr 903
447769 AW873704 Hs 320831 Homo sapiens cDNA FLJ14597 fis, clone NT 901
408393 AW015318 Hs 23165 ESTs 899
407966 AA295052 Hs 38516 Homo sapiens, done MGC 15887, mRNA, com 899
450534 AI570189 Hs 25132 KIAA0470 gene product 891
410101 AI338045 Hs 203559 hypothetical protein FU12701 890
417129 AI381800 Hs 300684 caicitoniπ gene-related pepdde-receptor 886
453507 AF083217 Hs 33085 WD repeat domain 3 868
442739 NM 007274 Hs 8679 cytosolic xyl coenzyme A thioester hydr 846
456249 AI206144 Hs 82508 HRIHFB2206 protein 838
437786 BE142681 Hs 155573 polymerase (DNA dirxted), eta 8 35
448410 AK000227 Hs 21126 hypothedcal protein FU20220 820
442711 AF151073 Hs 8645 hypothetical protein 8 14
408405 AK001332 Hs 44672 hypothedcal protein FU10470 796
420208 BE276055 Hs 95972 silver (mouse homolog) like 788
415929 AA724373 Hs 49344 hypothetical protein FLJ11006 7 79
449217 AA278536 Hs 23262 πbonuclease, RNase A family, k6 7 66
451239 H24302 Hs 23127 ESTs 750
442426 AI373062 Hs 332938 hypothedcal protein MGC5370 740
447233 AW246333 Hs 17901 Homo sapiens, clone IMAGE 3937015, mRNA, 739
439574 AI469788 ESTs 7 13
431360 NM 000427 Hs 251680 loncnn 7 12
412438 AI087928 Hs 110741 ESTs 6 %
452882 AW972990 Hs 196270 folate transporter/earner 687
436581 AA725726 Hs 180213 ESTs 664 431317 AA502682 gb ng23d01 s1 NCI_CGAP_0v2 Homo sapiens 663
443264 BE221477 Hs 132137 ESTs, Moderately similar to A47582 B-cel 658
412490 AW803564 Hs 288850 Homo sapiens cDNA FU22528 fis, clone H 653
408367 AK001178 Hs 44424 homolog of rat orphan transporter v7-3 652
413283 R78669 Hs 23756 hypothetical protein similar to swine x 650
453878 AW964440 Hs 19025 DC32 648
424148 BE242274 Hs 1741 integnn, beta 7 644
407876 NM 004519 Hs 40866 potassium voltage-gated channel, KQT-lik 644
409512 AW979187 Hs 293591 melanoma differentiation assxiated prot 639
427951 AI826125 Hs 43546 ESTs 632
448664 AI879317 Hs 334691 splicing fxtor 3a, subunit 1, 1 0kD 603
416640 BE262478 Hs 79404 neuron-specific protein 601
446830 BE179030 Human DNA sequence from clone RP51174N9 598
452629 W02772 Hs 180178 Homo sapiens, ctone IMAGE 3947276, mRNA, 593
427390 AI432163 Hs 268231 Homo sapiens cDNA FU23111 fis, clone L 573
427853 AI569798 Hs 98260 ESTs 555
434398 AA121098 Hs 3838 serum-inducible kinase (SNK) 554
450256 AA286887 Hs 24724 MFH-amplified sequences with leucine-πc 554
428524 AA429772 ESTs 553
431797 8E169641 Hs 270134 hypothedcal protein FU20280 550
418403 D86978 Hs 84790 KIAA0225 protein 550
411524 AW850303 gb IL3-CT0219-191199-030-F09 CT0219 Homo 547
426158 NM 001982 Hs 199067 v-erb-b2 avian erythroblasdc leukemia v 540
443086 AW977125 sine oculis homeobox (Drosophila) homolo 538
447735 AA775268 Hs 6127 Homo sapiens cDNA FU23020 fis, clone L 538
406843 AW196933 Hs 119598 nbosomal protein L3 536
430594 AK000790 Hs 246885 hypothedcal protein FU20783 535
447674 BE270640 Hs 19192 cyclm-dependent kinase 2 523
410491 AA465131 Hs 64001 Homo sapiens clone 25218 mRNA sequence 523
420338 AA825595 Hs 88269 Homo sapiens, clone MGC 17339, mRNA, com 509
409264 NM 014937 Hs 52463 KIAA0966 protein 503
414734 AA151712 Hs 82572 ESTs 501
426759 AI590401 Hs 21213 ESTs 499
426793 X89887 Hs 172350 HIR (histone cell cycle regulation defx 498
428612 AA770001 ESTs 497
413550 W03011 Hs 306881 MSTP043 protein 492
447349 AI375546 gb tc23d04 x1 Soares.total_fetus_Nb2HF8_ 486
403328 Target Exon 485
452840 AI097393 Hs 43481 hypothetical protein DKFZp564K192 483
439310 AF086120 Hs 102793 ESTs 482
451281 AI768965 Hs 292708 ESTs 4 82
431183 NM 006855 Hs 250696 KDEL (Lys-Asp-Glu-Leu) endoplasmic rede 481
427871 AW992405 Hs 59622 Homo sapiens, clone IMAGE 3507281 , mRNA, 474
435963 AF271212 Hs 322901 disrupter of silencing 10 467
418699 BE539639 Hs 173030 ESTs, Weakly similar to ALU8.HUMAN ALU S 466
414770 BE257224 Homo sapiens, clone IMAGE 3873720, mRNA 466
419628 H67546 Hs 49768 ESTs 464
420258 AA477514 Hs 96247 translin-assxiated fxtor X 463
446341 AL040763 Hs 310735 ESTs, Moderately similar to ALU7_HUMAN A 458
420267 N37030 Hs 173337 ESTs 4 57
412228 AW503785 Hs 73792 complement component (3d/Epsteιn Barr vi 455
432888 T86823 gb yd81a08 s1 Soares fetal liver spleen 455
453258 AW293134 Hs 32597 nng finger protein (C3H2C3 type) 6 453
418340 NM 013286 Hs 84162 chromosome 3p21 1 gene sequence 450
409038 T97490 Hs 50002 small inducible cytokine subfamily A (Cy 444
447484 AA464839 Hs 292566 hypothedcal protein FU 14697 442
452036 NM 003966 Hs 27621 sema domain, seven thrombospondin repeat 441
406903 K03121 gb Human glyceraldehyde-3-phosphate dehy 440
405451 dihydropyπmidmase-like 3 434
434203 BE262677 Hs 283558 hypothedcal protein PR01855 433
450088 AW292933 Hs 254110 ESTs 4 31
421535 AB0O2359 Hs 105478 phosphonbosylformylglycmamidine syntha 431
415912 H08859 Hs 206469 ESTs, Weakly similar to ALU6.HUMAN ALU S 430
451259 NM 006052 Hs 26146 Down syndrome cπdcal region gene 3 429
452548 AL050321 Hs 301532 CRP2 binding protein 4 28
432195 AJ243669 Hs 8127 KIAA0144 gene product 424
445101 T75202 Hs 12314 Homo sapiens mRNA, cDNA DKFZp586Cl019 (f 4 22
425913 AA365799 SEC22, vesicle trafficking protein (S c 419
423494 AW504365 Hs 24143 Wiskott-Aldnch syndrome protein interx 4 18
442092 AW578669 hypothedcal protein FU 12439 416
424954 NM 000546 Hs 1846 tumor protein p53 (Li-Frau eπi syndrome) 405
427719 AI393122 Hs 134726 ESTs 404
415310 R16313 gb yf93h09 r1 Soares infant bran 1 NIB H 404
416058 L08895 Hs 78995 MADS box transcnpdon enhancer fxtor 2 403
427828 AI024471 Hs 98232 ESTs 393
410079 U94362 Hs 58589 glycogenm 2 392
420265 AA766209 Hs 88087 ESTs 392
426181 AA371422 Hs 334371 hypothetical protein MGC13096 390
431639 AK000680 Hs 266175 phosphoprotein assxiated with GEMs 389
410275 U85658 Hs 61796 transcnpdon fxtor AP-2 gamma (xdvat 388
422150 AI867118 calpastatin 387
429238 NM 002849 Hs 198288 protein tyrosine phosphatase, receptor t 386
418827 BE327311 Hs 47166 HT021 384 425050 BE391854 Hs 7970 gb 601285394F1 NIH.MGC.44 Homo sapiens c 382
442271 AF000652 Hs 8180 syndxan binding protein (syntenm) 381
410235 AA082977 gb zn07h10 r1 Stratagene hNT neuron (937 379
408636 BE294925 Hs 46680 CGI- 12 protein 378
424624 AB032947 Hs 151301 Ca2*dependent xdvator protein for sxr 376
411400 AA311919 Hs 69851 nucleolar protein family A, member 1 (H/ 374
458215 AA928160 gb on86f10 s1 Soares_NFL.T_GBC_S1 Homo s 373
452874 AK001061 Hs 30925 hypothedcal protein FU10199 372
442643 U82756 PRP4/STK/WD splicing fxtor 370
447471 AF039843 Hs 18676 sprouty (Drosophila) homolog 2 370
447644 AW861622 Hs 108646 Homo sapiens cDNA FU14934 fis, clone PL 367
422616 BE300330 Hs 118725 selenophosphate synthetase 2 364
433160 AW207002 Hs 134342 TASP for tesds-spxific adnamycin sens 364
418180 BE618087 Hs 83724 hypothedcal protein MGC5466 362
423032 AI684746 Hs 119274 RAS p21 protein xdvator (GTPase xdva 362
425569 AA359597 Hs 301701 Homo sapiens cDNA FU12073 fis, clone HE 362
412156 H29487 Hs 17110 Homo sapiens mRNA cDNA DKFZp434C2016 (f 361
417426 NM 002291 Hs 82124 laminin, beta 1 361
407188 AA457592 gb aa92f 11 s1 Stratagene fetal redna 93 361
426600 NM 003378 Hs 171014 VGF nerve growth fxtor inducible 361
440760 AK0O1145 Hs 284216 hypothedcal protein FU10283 360
448481 W15284 Hs 74832 ESTs 359
414111 8E047679 Hs 152982 hypothedcal protein FU13117 359
437862 AW978107 HS 5884 Homo sapiens mRNA, cDNA DKFZp586C0224 (f 359
409703 NM 006187 Hs 56009 2-5'-olιgoadenylate synthetase 3 (100 k 359
406981 S71129 xetylcholinesterase (YT blood group) 359
431586 AW971100 Hs 293189 ESTs 358
415173 AW501735 Hs 180059 ESTs 357
430512 AF182294 Hs 241578 U6 snRNA-assxiated Sm-like protein LSm8 357
446126 AW085909 plxkstπn homology domain interxdng p 357
409305 AA070078 gb zm60f05 r1 Stratagene fibroblast (937 3 57
433867 AK000596 Hs 3618 hippocalcm-like 1 356
459721 AI299050 Hs 143835 gb qn14d12 x1 NCI CGAP Lu5 Homo sapiens 356
441412 AI393657 Hs 159750 ESTs 355
416114 AI695549 Hs 183868 glucuronidase, beta 355
454870 AW836081 gb PMO-LT0019-090300-002-e11 LT0019 Homo 354
443105 X96753 Hs 9004 chondroidn sulfate proteoglycan 4 ( ela 353
444680 AI186671 Hs 22670 ESTs 351
413949 AA316077 Hs 75639 Human TB1 gene mRNA, 3' end 3 51
437033 AW248364 Hs 5409 RNA polymerase I subunit 350
412141 AM 83838 Hs 48938 hypothetical protein FU21802 349
437158 AW090198 KIAA1150 protein 348
432642 BE297635 Hs 3069 heat shxk 70kD protein 9B (mortalm-2) 347
440634 AA921767 Hs 132447 ESTs 347
445652 AL117473 Hs 13036 DKFZP727A071 protein 346
429500 X78565 Hs 289114 hexabrxhion (tenascin C, cytotxdn) 343
420460 AA262331 Hs 48376 Homo sapiens clone HB-2 mRNA sequence 343
426141 C05886 Hs 293972 ESTs 340
424321 W74048 Hs 1765 lymphxyte-spxific protein tyrosine kin 340
449209 BE616830 Hs 294145 ESTs 339
408304 AW810279 gb MR4-ST0125151299-029-a09 ST0125 Homo 337
416561 D87328 Hs 79375 hol∞arboxylase synthetase (bιotιn-[prop 3 35
422947 AA306782 Hs 122552 G-2 and S-phase expressed 1 334
453005 AW055308 Hs 31803 ESTs, Weakly similar to N-WASP [H sapien 334
409430 R21945 Hs 346735 splicing fxtor, aginine/seπne-πch 5 332
417386 AL037228 Hs 82043 D123 gene product 332
440999 AI951562 Hs 126370 ESTs, Weakly similar to CNE3_HUMAN COPIN 331
407516 X64974 gb H sapiens mRNA HTPCRH02 for olfxtory 331
450065 AL050107 Hs 24341 traπscπpdonal co-xdvator with PDZ-bi 331
416902 AA375634 Hs 288974 hypothedcal protein FU12528 328
432878 BE386490 Hs 279663 Piππ 328
443296 AI765286 Hs 313342 ESTs 3 27
429954 AI918130 Hs 21374 ESTs 325
428044 AA093322 Hs 301404 RNA binding modf protein 3 325
425317 AW205118 Hs 210546 interieukin 21 rxeptor 325
418064 BE387287 Hs 83384 SlOOcalcium-binding protein, beta (neur 325
432917 NM 014125 Hs 241517 PRO0327 protein 3 24
447871 BE297946 Hs 239052 ESTs 324
414829 AA321568 Hs 77436 pteckston 324
426996 AW968934 Hs 173108 Homo sapiens cDNA FU21897 fis, clone H 323
416188 BE157260 Hs 79070 v-myc avian myetocytomatosis viral oncog 322
429530 AA454191 Hs 99362 Human DNA sequence from clone RP11-530N1 3 21
445174 AV652850 Hs 172004 ddn 319
459227 AW167599 ESTs 3 19
439039 AI656707 Hs 48713 ESTs 3 15
418803 U50079 Hs 88556 histone dexetylase 1 315
420005 AW271106 Hs 133294 ESTs 315
422511 AU076442 Hs 117938 collagen, type XVII, alpha 1 3 14
452480 AI903526 gb RC-BT031-090199-063 BT031 Homo sapien 314
445701 AF055581 Hs 13131 lymphxyte adaptor protein 3 14
410678 BE540516 Hs 293732 hypothedcal protein MGC3195 3 14
458664 AI300427 gb qo18h07 x1 NCI_CGAP_Lu5 Homo sapiens 313
436315 BE390513 Hs 27935 hypothedcal protein MGC4837 313 430441 BE398091 desmoplakin (DPI, DPII) 3 12
435080 AI831760 Hs 155111 hypothedcal protein FU14428 312
425606 U52112 Hs 158331 renin-bindmg protein 3 11
432978 AF126743 Hs 279884 DNAJ domain-containing 311
452826 BE245286 Hs 301636 peroxisomal biogenesis fxtor 6 3 10
446627 AI973016 Hs 15725 hypothetical protein SBBI48 310
427647 W19744 Hs 180059 Homo sapiens cDNA FU20653 (is, clone KA 309
417211 T97617 Hs 269092 ESTs 308
448140 AF146761 Hs 20450 BCM-like membrane protein precursor 308
448752 AA593867 Hs 300842 KIAA1608 protein 307
416355 H49875 Hs 268906 ESTs 307
425345 AU077297 Hs 155894 protein tyrosine phosphatase, non-rxept 307
410321 Y12860 Hs 62245 solute earner family 25 (mitochondnal 307
411395 AA889673 Hs 7542 KIAA1802 protein 307
416065 BE267931 Hs 78996 proliferating cell nuclea andgen 306
432343 NM 002960 Hs 2961 S100 calcium-binding protein A3 306
457991 BE539951 Hs 306996 Homo sapiens, clone IMAGE 3447073, mRNA, 305
433201 AB040896 Hs 21104 KIAA1463 protein 303
416178 AI808527 Hs 192822 serologically defined breast cancer and 302
411975 AI916058 Hs 144583 ESTs 301
448719 AA033627 Hs 21858 frmucleodde repeat contanmg 3 300
419870 AW403911 Hs 266175 phosphoprotein assxiated with GEMs 300
409601 AF237621 Hs 80828 keradn 1 (epidermolydc hyperkeratosis) 294
415668 AW957684 Hs 306814 hypothedcal protein FU21889 293
453256 AI565587 Hs 32556 KIAA0379 protein 281
436856 AI469355 Hs 127310 ESTs 275
417880 BE241595 Hs 82848 selxdπ L (lymphocyte adhesion molxule 260
408209 NM 004454 Hs 43697 ets vanant gene 5 (ets related molxule 259
440457 BE387593 Hs 21321 Homo sapiens clone FLB9213 PR02474 mRNA, 2 55
415314 N88802 Hs 5422 gly∞protein M6B 251
434276 AF123659 Hs 93605 leucine zipper, putadve tumor suppresso 2 50
424085 NM 002914 Hs 139226 replicadon fxtor C (xdvator 1) 2 (40 248
410600 AW575742 ESTs, Moderately similar to S65657 alpha 248
439180 AI393742 Hs 199067 v-erb-b2 avian erythroblasdc leukemia v 243
444809 BE207568 Hs 208219 xulospanm 239
453837 AL138387 Hs 256126 bxuloviral IAP repeat-contanmg 7 (liv 2 39
410290 AA402307 Hs 322844 hypothedcal protein DKFZp564A176 237
411358 R47479 Hs 94761 KIAA1691 protein 235
427550 BE242818 Hs 311609 nuclea RNA helicase, DECD vanant of DE 234
426312 AF026939 Hs 181874 interferon-induced protein with letratπ 229
448569 BE382657 Hs 21486 signal transducer and xdvator of trans 2 27
418661 NM 001949 Hs 1189 E2F transcnpdon fxtor 3 224
459373 BE408266 Hs 301406 hypothedcal protein PP3501 2 21
417437 U52682 Hs 82132 interferon regulatory fxtor 4 221
436700 AI693690 Hs 301406 hypothedcal protein PP3501 2 18
450690 AA296696 Hs 333418 FXYD domain-containing ion transport reg 2 15
432800 BE391046 Hs 278962 AIM-1 protein 215
421773 W69233 Hs 112457 ESTs 209
409415 AA579258 Hs 6083 Homo sapiens cDNA FLJ21028 fis, clone C 203
433364 AI075407 Hs 296083 ESTs, Moderately similar to I54374 gene 202
412609 Z48804 Hs 74124 xular albinism 1 (Nettleship-Falls) 201
443950 NM 001425 Hs 9999 epithelial membrane protein 3 201
451537 R56631 Hs 26550 retinoid X rxeptor, gamma 200
427080 AW068287 Hs 301175 ras-related C3 botulmum toxin substrate 1 96
413190 AA151802 Hs 40368 adaptor-related protein complex 1, sigma 1 94
412926 AI879076 Hs 75061 mxrophage myπstoylated alanine rich C 1 91
453779 N35187 Hs 43388 28kD interferon responsive protein 1 86
453107 NM 016113 Hs 279746 vanilloid receptor-like protein 1 1 86
430637 BE160081 Hs 256290 S100 calcium-binding protein A11 (calgiz 1 86
408561 AI308037 Hs 84120 hypothetical protein MGC13016 1 84
413171 AA318325 Hs 75219 tyrosinase-related protein 1 1 83
406016 Target Exon 1 82
446644 NM 003272 Hs 15791 transmembrane 7 superfamily member 1 (up 1 81
431836 AF178532 Hs 271411 beta-site APP-cleavmg enzyme 2 1 77
439496 BE616501 Hs 32343 Homo sapiens, Similar to RIKEN cDNA 1110 1 77
447604 AW089933 Hs 301342 hypothetical protein MGC4342 1 76
438866 U44385 Hs 325495 dssue inhibitor of metalloproteinase 2 1 74
440672 AF083811 Hs 7345 MAD1 (mitodc arrest deficient, yeast, h 1 70
416091 AF295370 Hs 283082 defensin, beta 3 1 69
446291 BE397753 Hs 14623 interferon, gamma- ducible protein 30 1 67
422532 AL008726 Hs 118126 protective protein for beta-galxtosidas 1 67
418918 X07871 Hs 89476 CD2 antigen (p50), sheep red blood cell 1 67
412580 AA113262 Hs 17901 Homo sapiens, clone IMAGE 3937015, mRNA, 1 67
448258 BE386983 Hs 343214 hypothetical protein FLJ20396 1 66
414945 BE076358 Hs 77667 lymphxyte andgen 6 complex, Ixus E 1 66
425262 D87119 Hs 155418 GS3955 protein 1 65
439237 AW408158 Hs 318893 ESTs, Weakly similar to A47582 B-cell gr 1 64
427923 AW274357 Hs 301406 hypothetical protein PP3501 1 63
424825 AF207069 Hs 153357 procollagen lysine, 2-oxoglutarate 5-dιo 1 62
441859 AW194364 Hs 94814 ιnterteukιn-4 induced gene-1 protein (FI 1 60
445982 BE410233 Hs 13501 pescadilto (zebrafish) homolog 1, conta 1 58
412939 AW411491 Hs 75069 eukaryodc translation elongadon fxtor 1 58
417237 H86385 Hs 81737 palmitoyl-protein thioesterase 2 1 56 412856 BE386745 Hs 74631 basigiπ (OK blood group) 1 56
447200 BE543146 Hs 281434 Homo sapiens cONA FLJ14028 fis, clone HE 1 54
409614 BE297412 Hs 55189 hypothetical protein 1 53
450663 H43540 Hs 25292 nbonuclease HI, large subunit 1 53
423397 NM 001838 Hs 1652 chemokine (C-C modi) rxeptor 7 1 49
425535 AB007937 Hs 158287 KIAA0468 gene product 148
409340 BE174629 Hs 321130 hypothedcal protein MGC2771 1 46
446755 AW451473 Hs 16134 senne/threonine kinase 10 1 46
454429 BE273437 Hs 301406 hypothedcal protein PP3501 1 46
425722 AI659076 Hs 97031 hypothetical protein MGC13047 1 45
414509 AW161311 Hs 76294 CD63 andgen (melanoma 1 andgen) 144
452203 X57522 transporter 1, ATP-bmding cassette, sub 1 43
436378 AJ227874 Hs 99244 ESTs 1 42
424218 AF031824 Hs 143212 cystadn F (leukxystadn) 1 42
436456 AW292677 Hs 248122 G protein-coupled receptor 24 1 42
439740 AL365512 Hs6657 hypothedcal protein bK1048E95 142
429359 W00482 Hs 2399 matnx metalloproteinase 14 (membrane-in 1 42
427634 AI399745 Hs 18449 hypothedcal protein MGC10820 1 40
403409 NM_005929 Homo sapiens antigen p97 (mela 1 40
434262 AF121858 Hs 12169 sorting nexm 8 1 34
413566 AW604451 Hs 285814 sprouty (Drosophila) homolog 4 132
427730 AW250549 Hs 180577 granulin 1 32
411742 AW247593 Hs 71819 eukaryodc translation initiation fxtor 1 31
450395 BE048545 Hs 161757 ESTs 1 30
413291 NM 006278 Hs 75268 sialylfransferase 4C (beta-galactosidase 1 26
442609 AL020996 Hs 8518 selenoprotem N 1 24
416929 N20535 melastadn 1 1 21
421975 AW961017 Hs 6459 hypothedcal protein FU11856 1 21
454478 AW805749 superoxide dis utase 2, mitxhondnal 1 20
437723 AI672731 Hs 13256 ESTs 1 18
416350 AF188625 Hs 189507 phospholipase A2, group IID 1 08
TABLE 48B
Pkey Uniq ue Eos probeset idendfier number
CAT number Gene cluster number
Accession i Genbank axession numbers
Pkey CAT Number Axession
430540 713_2 BC017171 BC012195 NM_007126 AF100752 AL137377 Z70768 B M47486
BM045810 AU120387 BG770238 $3686740 BG913323 BI759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847
AI770171 BF196861 BE856897 AA463876 AI375927 AA648810 AA948193 AA490916 AI459893 AI458188 AI240408 AI191843 AI131029 AW768399
AI365196 AW337984 AW026150 BE466591 BE674599 AI818438 AA772197 AI651927 AW151143 BI198825 BG819083 BM458764 BE903567
BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542 AW246215 BE501897 BE903610
BE561530 BE560537 BE903782 BE732947 BI227204 BG761305 BE262642 BE391848 BE382475 BG008258 BI547991 BI459099 BE391391 BE259420
BE298109 AW245422 AI423847 AI914618 H80534 BE301004 AL531791 AI435581 BF793112 AL577303 AA373265 BE746965 BF743630 BE879296
AI359493 BM018598 AI689260 AW072450 F20201 AW151405 AW517572 AA773468 BG259694 BE391163 BG621529 AI421728 BG767231 BM462953
BG340524 W52648 AA113434 BE785431 BI041981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 BI091658 N72512
W58732 W85690 BG958989 AI205206 H19721 W17051 W77958 BI262010 AA844319 W74143 W72214 N85194 BE734033 BG164099 AA931069
F13645 R41394 AK025758 BG180977 BE349455 AA812018 AA740241 AI027722 AI150356 AA886395 AW977627 BE220225 AA884082 AW518114
AI243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 AI251109 R07704 AA765606 AA724593 AI918399 AI537550 AA491103
AW008188 R07703 AA989120 AA746235 AW028983 AA789102 AU185751 AW971465 AA489681 AW971893 AW612086 BE077936 BI860809
BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591
454088 1007145J AW062425AW062411 458997 11847_4 BM453041 AA760783 BE218582AI340046 AW166131 BF515854 A1630296 AA461307 A1090881 AW023059 AA155797 AA115486 AL597396
AW889004 AW937420 AA137082 AA013374 BG619478 BG401839
446019 658727 AI362520025917 AI670784 AI742347 AW269789 AI270700 AW610541 AW793036 AW793035 AW610540 AW362220 AW362166 AW362214
AW362225 AW362228 AL119827 430015 713 2 BC017171 BC012195 NM.007126 AF100752 AL137377 Z70768 BM474865 BG754806 AU124376 BG757203 BG764420 BG775028 BG824418
BM045810 AU120387 BG770238 BG686740 BG913323 BI759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847
AI770171 BF196861 BE856897 AA463876 AI375927 AA648810 AA948193 AA490916 AI459893 AI458188 AI240408 AI191843 Al 131029 AW768399
AI365196 AW337984 AW026150 BE466591 BE674599 AI818438 AA772197 AI651927 AW151143 BI198825 BG819083 BM458764 BE903567
BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542 AW246215 BE501897 BE903610
BE561530 BE560537 BE903782 BE732947 BI227204 BG761305 BE262642 BE391848 BE382475 BG00825881547991 BI459099 BE391391 BE259420
BE298109 AW245422 AI423847 AI914618 H80534 BE301004 AL531791 AI435581 BF793112 AL577303 AA373265 BE746965 BF743630 BE879296
AI359493 BM018598 AI689260 AW072450 F20201 AW151405 AW517572 AA773468 BG259694 BE391163 BG621529 AI421728 BG767231 BM462953
BG340524 W52648 AA113434 BE785431 BI041981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 BI091658 N72512
W58732 W85690 BG958989 AI205206 H19721 W17051 W77958 BI262010 AA844319 W74143 W72214 N85194 BE734033 BG164099 AA931069
F13645 R41394 AK025758 BG180977 BE349455 AA812018AA740241 AI027722 AI150356 AA886395 AW977627 BE220225 AA884082AW518114
AI243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 AI251109 R07704 AA765606 AA724593 AI918399 AI537550 AA491103
AW008188 R07703 AA989120 AA746235 AW028983 AA789102 AU185751 AW971465 AA489681 AW971893 AW612086 BE077936 BI860809
BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591
453912 32562.3 BM472224 BI966849 BI966735 AW973032 BI962894 BI963048 AA548765 AI926504 AA041551 AW043754 AI086702 AW008105 AA974849 AW614893
AA553737 AA916996 AW262982 AI580991 BF726843 AV693312 W35325 AA039927 BG460936 AW388482 AW388420 BF374777 W01360 N94710
H87967
409078 744783.1 AW327515 AW327774 AW327571 458098 23945.1 AI082245 BE467534 AI797130 BE467063 BE467767 BE218421 AI694996 BE327781 8E327407 BE833829 AA989054 AA459718 BE833855 BE550224
AA832519 AF086393 AV733386 BE465409 N29245 W07677 AA482971 BE503548 H18151 AA461301 W79223 W74510 AI090689 AL600773 AL600781
N46003 R28075 R34182 BE071550 AW885857 AI276145 AI276696 H97808 N20540 AI468553
421334 267495.1 BG758353 AA287401 BE295646 AL040858 439574 689966.1 BG532820 AW246001 AI469788 AI350090 AI446788 BE549330 W84862 AA837988 431317 997174.1 AW970601 AW613399AA503435 AA502682 N91138 446830 41421.1 BC020595 BI488430 BG168023 BE179030 AW294203 BF849776 AA459064 AI917452 AW403072 W27419 BF914568 BF798468 AW370558 T35055
AW370623 AA399232 AA214221 AW802987 BF902228 AW370622 BF819597 AW370567 BF914313 AW954040 BF060706 AA194237 T25074 C01285 BI489433
428524 1382184.1 AI208080 AA442862 AA429772 411524 1089114.1 AW850587 AW850589 AW850318 AW850303 443086 25669 4 BE896316 BG819393 AA187888 AW753122 428612 1383189.1 AA770001 AA431112 AA432126 447349 1063443.1 BE743847 AW809603 BM469626 AI375546 414770 41721 1 AK056926 BG473673 BG482256 AL135566 AW419211 BF949370 AL120313 AV703730 H82569 BG012696 R27084 AA304583 BM452908 BF516419 BF515687 BG036572 BG696740 AW953552 AW859437 AA306038 AI754064 AA608729 AA664163 H65119 AW272606 BF942099 AW130468 BI089467 BG821499 AA152403 BF310450 BF314240BG830310 BF803223 BG764269 BE542645 BE259142 R26953 BE257224 BG475461 BF677821 R33048
432888 2155976.1 T86823 AA570737 AI821425 AA569589 AI732232 425913 4123.2 AV703649 AW959818 AI582119 AI523459 AI674473 AW663543 AA825476 AI935231 BF742805 AA426156 AI253626 AA846477 AI024230 BF221780 AI493027 AW006841 AA814699 H99650 AI088977 AA442691 AI783526 BF207915 AI752847 AA782635 AI978980 AA788634 BG119454 BF678528 AI627829 BG993975 AV701283
442092 22756.2 BM449821 BM069895 BM023170 AW025563 BG152606 BM023452 AI862106 BG959957 415310 1869807.1 R16313 Z45351 R14838 F05290 R14821 R16277 422150 782.1 BI086421 BF059136 AW003898 BF446659 AI632891 AI628067 AI703179 AI961149 BF111022 AW614154 BE674215 AA687350 AA779426 BF591963 AW243344 AI356530 AI492508 AI694049 AIO90422 AA465307 AI273387 BE674625 AW271971 AA969153 AW468593 AA984014 AI817491 AA970258 AI914450 AI018697 AW577591 AW577616 AA382101 AW954455 AI867266 AI707995 AI337384 BF208406 BF037100 BF223433 BF195517 BE673984 BF224124 BE813387 BG036579 BI553906 AA304995 AW361269 AW754160 AW361276 AW361271 AI867118 AW805555 AW361284 AW954458 AW958551 BG681507 H79011 AW205696 AW134957 AA747667 AW753296 BF939060 AW958549 BF910827 BG573750 BGt68639
410235 2930253.1 AA082977 AA082955 458215 540112.3 BE176902 BE177058 442643 2736.1 BC001588 BC007424 AF016369 NM.004697 BI756186 BE257019 BG500792 BI862776 AL121371 BG574833 AA703250AA179511 AW052006 AI280150 AI914000 Al 358319 AI081204 AI082594 AA992449 AI470821 AI655744 AW237529 AA678858 AI984430 BF433055 BE467594 BE467573 AA035630 AI289987 AI184802 AI681391 AW592416 AI138377 AI139266 AA961714 AI800163 AA418751 AW451928 AA668676 AI273444 AI494387 BE046912 AI276555 BF196021 AA700O55 AA609305 AA772596 AI635758 AI635749 H95459 AW610290 BE464994 AA527136 BF374802 AI800175 AW195227 AI189676 BF802049 AL513632 AL554911 AL538845 BE297273 AA315321 BM451920 BE269268 BE292835 BE018128 BG755713 BM041095 BG677009 AL039691 BF995709 BE735586 BE296453 BG393609 BG824453 AL567522 AI745257 AW388641 AW301265 AI141144 AW029280 AU149362 AU152328 AA418960 AL121009 AI890398 AL528748 H13050 T47086 BI000575 BF334914 BF109661 R44450 H13259 T47087 AW388646 BF305834 AL577515 BM041600 BE889299 BF239768
446126 610.2 BF946219 BF946218 BF851494 AL536879 AA457150 AI590194 AI582629 AA464515 AA916242 AA337109 AA336509 N46906 AA336322 AA336407 AA337222 AA319240 BI026817 BI027058 AL536880 AI693827 AA651730 AI701013 BM068789 AW339506 AA293021 BF891108 AI458885 AW361203 AW974652 AI761251 AI655763 AA628063 BE047125 AW085916 AI129587 N52070 AW172361 AA052951 AW085909 AI000008 AA962570 AI371342 AI364207 AA464514 AI962506 AI824603 AW376300 AA058439 AW361192 AV656660 N50282 BF820514 BF891008 H40784 BF891112 BE708029 AW043567AA056762
409305 109927.1 AA071475 AA112236 AA070648 AA071243 AA081725 AA085187 AA070078 454870 2170.9 AW836081 BF854404 AW578594 AW578581 BF507971 AW196760 AA779923 AA707233 AI655913 AA948295 AW089222 AW291883 437158 59575.1 AL050068 AA160485 AW173544 AW296506 AW439860 AI521563 AI702529 AI393606 AW138323 AA570109 H19504 BM021968 BF063327 BF593552 AA630766 AI597717 AI807128 AA523012 AI356250 AW451857 AA974203 AI762577 BF512552 AW007307 BE675286 AW450602 AA962057 AW516069 AI582546 BF221924 BF222543 AI801808 AW468599 AW0O0736 AI866625 AW235356 BM021837 AA911956 AI680606 W86516 T03370 AW611634 H41653 AI468349 H19588 AW090198 AW043993 R39847
408304 646409.1 AW810279 BE146684 AW810193 AW810515 AW178835 AW810516 BE146689 AW178842 BE146693 BE146694 AW810208 AW810258 AW810447 AW810443 AW810330 AW810211 AW810328 AW810327 AW810288 AW810265 AW810257 AW810263 AW810567 AW178838 AW810323 AW810358 AW810281 AW810321 AW178837 AW810635 BE062400 AW810198 AW810325 AW810513 BE062434 BE146679 AW810441 AW846649 AW810536 AW178857 AW810185 BE146653 AW810636 AW810322 BE146674 AW810359 AW810293 AW810472 AW178852 AW810356 AW810514 AW810289 BE146652 AW810566
459227 639802.1 AW167599 AI971179 AI934948 452480 3144986.1 AI903574 AI903572 AI903526 AI903571 458664 2139033.1 BF432937 R07053 AI300427 W57876 430441 1438.6 BG108218 BE560548 AW380115 BE269629 AI911518 AW380113 AA902964 AA455001 AI276529 AI685597 AA970496 D61084 AW380068 AW380080 R00283 C15236 AW327776 D80759
410600 497855.1 BF347859 AW499616 AA191322 AW499617 AL601010 AW575742 AA729043 BE463447 AA086179 BE549623 AI335824 AW4087128M149172 452203 2630.1 BC014081 NMJ00593 X57522 L21208 L21207 L21206 L21205 L21204 AL561404 AL546423 AL560492 AL556882 AL541576 AL550654 BI823519 BI770023 AL554969 BI489906 AI304693 AW295947 BM146642 X57521 BG820143 8E898390 F06770 F12630 BM423610 AL561518 BM009470 BG742981 AA279685 AA847441 AA313737 BF172639 BF897216 BF914190 BF903647 S70277 AI569694 AW073296 AI361433 AA564644 AA487429 BE858232 AA838610 AI539114 AI719375 AI829129 BG057675 AI423422 AU158860 BE300655 AW170777 AA586956 AL571889 AL556850 AL576404 AL582800 BI256544 BF342301 BG875994 AA054458 AA353161 AI940434 BE816522 AL577636 AI479650 AW150377 AU154395 AW951271 AI032220 AI819778 AI346733 AW771150 AW512525 AI249904 AA279809 AI352549 AW512517 BG056280 AA521222 BE271141 AL581932 AL541575 BI819184 AV660190 AL556475 AI620020 AW089888 AW079179 Z21518 AA687601 F04651 AI783961 T57198 AI433367 T78652 AL554968 AA365648 AL582619 BE874601 BF804669 AL574458 BM145502 AI266514 AI538823 AI475626 AA948210 AA884054 AA487637 AA031844 AA535221 AW794256 AW361447 BE788505 AI682892 AA830989 AA862356 AA653084 BM009154 AA135727 H05927 H23433 R42244 N79997 AW366665 AW366601 AA678742 AL556474 AA135770 BE774050 BF914200 H88457 AA627746 BI560216 BI753586
416929 14596.3 BC017849 BC005892 N42983 BF691239 N42991 N29240 N40292 N33322 N33330 N20535
454478 4273.16 AW796921 AW798102 AW805749 AW805872 BF985060 AW794380 BF380449 AW794466 AW794538
TABLE 48C
Pkey Unique number conesponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publication endded The DNA sequence of human chromosome 22* Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposidon Indicates nucleotide positions of predicted exons
Pkey Ref Strand NLposidon
403328 8469086 Minus 120425120703
405451 7622517 Minus 145949-146227
406016 8272661 Plus 41341-41940
403409 9438598 Plus 6860-7054,1257512771
TABLE 49A ABOUT 1127 GENES UPREGULATED IN PRIMARY MELANOMA AND/OR MELANOMA METASTASES RELATIVE TO NORMAL BODY TISSUES Table 49A lists about 1127 genes upregulated in pπmary melanoma and/or melanoma metastases reladve to normal body dssues These genes were selxted from 59680 probesets on the Eos/Affymetox Hu03 Genxhip array Gene expression data for exh probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflxdng the relative level of mRNA expression Pkey Unique Eos probeset idendfier number ExAccn Exemplar Axession number, Genbank xcession number
UnigenelD Unigene number
Unigene Title Unigene gene title
R1 90th percendle of pπmary melanoma and melanoma metastasis Als divided by the 90th percendle of normal dssue Als
R2 90th percendle of pπmary melanoma and melanoma metastasis Als divided by the 90th percendle of normal dssue Als, where Ihe 15th percentile of normal tissue Als was subtraded from both the numerator and denominator
R3 90th percendle of pπmary melanoma and melanoma metastasis Als divided by the 90th percendle of heart, liver, lung, and kidney Als
Pkey ExAxn UnigenelD Unigene Tide R1 R2 R3
452838 U65011 Hs 30743 preferendally expressed andgen in mela 1405 11 83 1405 426555 NM_000372 Hs 2053 tyrosinase (xulxutaneous albinism IA) 13 15 1327 13 15
430377 NM_001922 Hs 301865 dopxhrome tautomerase (dopachrome delta 11 77 743 11 77
420208 BE276055 Hs 95972 silver (mouse homolog) like 1053 1995 1027
431360 NM_000427 Hs 251680 loπcπn 978 709 089
430822 AJ005371 Hs 248017 glycera.dehyde-3-phosphate dehydrogenase 940 720 884 422168 AA586894 Hs 112408 S100calcium-binding protein A7(psoπas 803 1027 1284
419628 H67546 Hs 49768 ESTs 756 892 649
438549 BE386801 Hs 21858 tnnucleodde repeat containing 3 752 547 1647
430686 NM.001942 Hs 2633 des oglein 1 606 13 331
409601 AF237621 Hs 80828 keradn 1 (epidermolydc hyperkeratosis) 586 922 0 7 429170 NM.001394 Hs 2359 dual spxificity phosphatase 4 584 346 584
428227 AA321649 Hs 2248 small inducible cytokine subfamily B (Cy 582 394 582
414812 X72755 Hs 77367 monokine induced by gamma interferon 581 333 679
453344 BE349075 Hs 44571 ESTs 578 307 598
425088 AA663372 Hs 169395 hypothedcal protein FU12015 560 392 560 402075 ENSP00000251056* Plasma membrane calcium 512 422 512
416975 NM.O04131 Hs 1051 granzyme B (granzyme 2, cytotoxic T-lymp 509 333 4 14
420602 AF060877 Hs 99236 regulator of G-protem signalling 20 506 578 506
426600 NM_003378 Hs 171014 VGF nerve growth fxtor inducible 504 677 942
430838 N46664 Hs 169395 hypothedcal protein FU12015 503 306 503 417542 J04129 Hs 82269 progestageπ-assxiated endo etnal prote 493 813 541
425234 AW152225 Hs 165909 ESTs, Weakly similar to I38022 hypothed 478 293 4 78
408962 BE386436 Hs 44317 SRY (sex determining region Y)-box 10 475 328 530
410361 BE391804 Hs 62661 guanylate binding protein 1, ιnterferon- 470 311 470
429903 AL134197 Hs 93597 cyclm-depeπdeπt kinase 5, regulatory su 468 227 468 407756 AA116021 Hs 38260 ubiquidn spxific protease 18 465 321 331
417166 AA431323 Hs 42146 ESTs 456 523 456
421773 W69233 Hs 112457 ESTs 452 11 11 096
442711 AF151073 Hs 8645 hypothedcal protein 4 37 370 430
457211 AW972565 Hs 32399 ESTs, Weakly similar to S51797 vasodilat 437 308 675 428513 BE220806 Hs 184697 Homo sapiens clone 23785 mRNA sequence 432 261 432
447937 AL109716 Hs 20034 Homo sapiens mRNA full length insert cDN 431 3 13 431
451099 R52795 Hs 25954 interieukin 13 rxeptor, alpha 2 4 28 289 217
433658 L03678 Hs 156110 immunoglobulin kappa constant 4 18 268 592
420301 AA767526 Hs 22030 paired box gene 5 (8-cell lineage spxif 4 16 2 57 416 433447 IJ29195 Hs 3281 neuronal pentraxin II 415 226 646
446341 AL040763 HS 310735 ESTs Moderately similar to ALU7.HUMAN A 4 10 404 464
408380 AF123050 Hs 44532 diubiquidn 402 246 5 33
421379 Y15221 Hs 103982 small inducible cytokine subfamily 8 (Cy 402 348 319
421633 AF121860 Hs 106260 sorting nexin 10 401 261 336 454117 BE410100 Hs 40368 adaptor-related protein complex 1, sιgma 396 268 396
417355 D13168 Hs 82002 endothelin rxeptor type B 395 246 366
420267 N37030 Hs 173337 ESTs 388 387 388
412228 AW503785 Hs 73792 complement component (3d/Epstem Ban vi 381 304 794
427528 AU0771 3 Hs 179565 minichromosome maintenance deficient (S 379 223 3 79 405451 dihydropynmidinase like 3 378 374 406
449078 AK001256 Hs 22975 KIAA1576 protein 3 76 283 376
423799 AW026300 Hs 132906 19A24 protein 375 236 375
456373 BE247706 Hs 89751 membrane-spanning 4-domaιns, subfamily A 373 259 697
444863 AW384082 Hs 104879 senne (or cysteine) proteinase mhibito 372 215 392 427666 AI791495 Hs 180142 calmodulin-like skin protein (CLSP) 369 417 1 18
415817 U88967 Hs 78867 protein tyrosine phosphatase, rxeptor-t 364 208 364
422423 AF283777 Hs 116481 C072 andgen 364 294 364
419956 AL137939 Hs 40096 cadhenn 19, type 2 356 222 468
420338 AA825595 Hs 88269 Homo sapiens, clone MGC 17339, mRNA, com 355 296 4 70 412140 AA219691 Hs 73625 RAB6 interxdng, kinesm-like (rabkmes 354 1 96 354
458079 AI796870 Hs 54277 ONA segment on chromosome X (unique) 992 3 53 218 327
444381 BE387335 Hs 283713 ESTs Weakly similar to S64054 hypothed 348 283 11 00
449722 BE280074 Hs 23960 cyclm B1 348 2 10 464
438380 T06430 Hs 6194 chondroidn sulfate proteoglycan BEHAB/b 347 390 498 452744 AI267652 Hs 246107 Homo sapiens mRNA, cDNA DKFZp434E082 (fr 345 238 345
447210 AF035269 Hs 17752 phosphaddylseππe-spxific phospholipas 344 383 209
428804 AK000713 Hs 193736 hypolhetical protein FU20706 343 239 343
407846 AA426202 Hs 40403 Cbp/p300-ιnterxdng transxdvator, wit 341 433 541
423605 AF047826 Hs 129887 cadhenn 19, type 2 340 1 97 406 421508 NM.004833 Hs 105115 absent in melanoma 2 338 277 546
428001 H97428 Hs 219907 ESTs, Moderately simila to Transforming 336 241 336
430770 AA765694 Hs 123296 ESTs 336 208 383
445784 AI253155 Hs 146065 ESTs 332 202 380 414646 AA353776 Hs 901 CD48 andgen (B-cell membrane protein) 332 1 87 376
448966 AW372914 Hs 86149 phosphoinositol 3-phosphate-bιndιng prot 3 31 210 331
441224 AU076964 Hs 7753 calumen 328 204 3 28
428242 H55709 Hs 2250 leukemia inhibitory fxtor (cholinergic 326 243 356
413385 M34455 Hs 840 indoleamme-pyπole 2,3 dioxygenase 324 294 285
416636 N32536 Hs 42645 solute earner family 16 (moπ∞arboxylic 323 1 84 387
415668 AW957684 Hs 306814 hypothedcal protein FU21889 3 22 310 3 13
442757 AI739528 Hs 28345 ESTs 322 341 1 45
426317 AA312350 Hs 169294 transcnpdon fxtor 7 (T-cell specific, 3 18 250 3 18
432874 W94322 Hs 279651 melanoma inhibitory xdvity 318 531 4 55
412561 NM 002286 Hs 74011 lymphxyte-xdvadon gene 3 3 17 309 428
443983 H04482 Hs 163724 ESTs 316 221 316
429732 U20158 Hs 2488 lymphxyte cytosolic protein 2 (SH2 doma 314 1 74 325
422363 T55979 Hs 115474 replication fxtor C (xdvator 1) 3 (38 3 14 207 333
422424 AI186431 Hs 296638 prostate differendadon fxtor 310 320 2 15
435256 AF193766 Hs 13872 cytokine-like protein C17 3 10 223 3 10
401747 Homo sapiens keradn 17 (KRT17) 3 10 210 302
447674 BE270640 Hs 19192 cyclm-dependent kinase 2 308 308 400
419870 AW403911 Hs 266175 phosphoprotein assxiated with GEMs 307 3 16 307
432878 BE386490 Hs 279663 Piπn 306 292 420
401454 NM_014226* Homo sapiens renal tumor and 305 1 96 305
410079 U94362 Hs 58589 glycogenin 2 301 226 327
426501 AW043782 Hs 293616 ESTs 301 200 368
418310 AA814100 Hs 86693 ESTs 300 235 676
422283 AW411307 Hs 114311 CDC45 (cell division cycle 45, S cerevis 296 231 378
422309 U79745 Hs 114924 solute earner family 16 (mon∞artxixylic 296 249 474
408418 AW963897 Hs 44743 KIAA1435 protein 294 1 80 294
432882 NM 013257 Hs 279696 serum/glucocorticoid regulated kmase-li 293 1 74 293
416640 BE262478 Hs 79404 neuron-specific protem 293 278 309
443264 BE221477 Hs 132137 ESTs, Moderately similar to A47582 B-cel 292 235 427
410491 AA465131 Hs 64001 Homo sapiens clone 25218 mRNA sequence 291 283 384
405545 Target Exon 290 244 290
451537 R56631 Hs 26550 rednoid X receptor, gamma 290 409 340
439926 AW014875 Hs 137007 ESTs 290 243 290
406673 M34996 Hs 198253 maior histocompadbility complex, class 289 322 1 44
418007 M13509 Hs 83169 matπx metalloproteinase 1 (interstitial 289 390 289
440065 W03476 Hs 266331 hypothedcal protein MGC4595 289 440 305
442739 NM 007274 Hs 8679 cytosolic xyl coenzyme A thioester hydr 288 236 454
424620 AA101043 Hs 151254 kallikrein 7 (chymotrγpdc, stratum com 286 323 1 95
407856 AA045281 Hs 266175 phosphoprotein assxiated with GEMs 284 1 84 284
430540 AW245422 Homo sapiens cDNA FU22105 fis, clone H 284 1 80 292
424153 AA451737 Hs 141496 MAGE-lιke 2 284 226 284
420798 W93774 Hs 99936 keradn 10 (epidermolydc hyperkeratosis 281 291 083
431317 AA502682 gb ng23d01 s1 NCI_CGAP_Ov2 Homo sapiens 281 2 17 296
424800 AL035588 Hs 153203 MyoD family inhibitor 280 206 4 10
448111 AA053486 Hs 20315 interferon-induced protein with tetratn 279 1 85 242
431183 NM 006855 Hs 250696 KDEL (Lys-Asp-Glu-Leu) endoplasmic rede 278 234 6 53
448719 AA033627 Hs 21858 tπnucleodde repeat containing 3 278 375 401
427951 AI826125 Hs 43546 ESTs 278 1 99 2 70
453912 AL121031 SWI/SNF related, matnx assxiated, xd 277 228 277
426711 AA383471 Hs 343800 consen/ed gene amplified in osteosarcoma 275 1 98 2 75
409430 R21945 Hs 346735 splicing fxtor, argininefeeπne-πch 5 274 318 360
409041 AB033025 Hs 50081 Hypothedcal protein, XP.051860 (KIAA119 272 2 24 272
442117 AW664964 Hs 128899 ESTs, hypothedcal protein for IMAGE 447 2 72 231 359
420552 AK000492 Hs 98806 hypothedcal protein 272 1 85 272
409103 AF251237 Hs 112208 XAGE-1 protein 272 218 272
439963 AW247529 Hs 6793 platelet-xdvadng fxtor xetylhydrola 271 2 20 448
413171 AA318325 Hs 75219 tyrosinase related protein 1 2 71 574 262
436700 AI693690 Hs 301406 hypothedcal protein PP3501 271 337 3 32
419098 AA234041 Hs 87271 ESTs 270 353 1 35
436608 AA628980 Hs 192371 down syndrome cndcal region protein DS 269 248 269
418067 AI127958 Hs 83393 cystadπ E M 268 304 056
439453 BE264974 Hs 6566 thyroid hormone receptor mterxtor 13 267 236 3 16
437723 AI672731 Hs 13256 ESTs 266 2 16 266
411252 AB018549 Hs 69328 MD-2 protein 266 1 81 266
424321 W74048 Hs 1765 lymphxyte-spxific protein tyrosine km 266 243 392
453837 AL138387 Hs 256126 bxuloviral IAP repeat-contaning 7 (liv 265 371 280
434826 AF155661 Hs 22265 pyruvate dehydrogenase phosphatase 264 1 85 472
414696 AF002020 Hs 76918 Niemann-Pick disease, type C1 264 207 264
444371 BE540274 Hs 239 forkhead box M1 264 282 446
436291 BE568452 Hs 344037 protein regulator ol cytokinesis 1 263 1 81 295
439310 AF086120 Hs 102793 ESTs 262 238 10 12
420218 AW958037 πbosomal protein L4 262 280 262
438746 AI885815 Hs 184727 Human melaπoma-assxiated andgen p97 (m 260 327 212
432828 AB042326 Hs 287402 chondroidn 4-sulfotraπsferase 260 267 303
408367 AK001178 Hs 44424 homolog of rat orphan transporter v7-3 2 59 322 259
408527 AL135018 Hs 33074 Homo sapiens, clone IMAGE 3606519, mRNA, 258 1 69 205
444809 BE207568 Hs 208219 xulospanm 258 277 288
432886 BE159028 Hs 279704 chromadn accessibility complex 1 258 1 83 258
434276 AF123659 Hs 93605 leucine zipper, putative tumor suppresso 255 370 3 28
412326 R07566 HS 73817 small inducible cytokine A3 (homologous 2 55 2 14 1 62
410174 AA306007 Hs 59461 DKFZP434C245 protein 255 207 255
447735 AA775268 Hs 6127 Homo sapiens cDNA FU23020 (is, clone L 254 2 17 401 422173 BE385828 Hs 250619 phorbolin-like protein MDS019 (CEM15) 253 1 68 316
418506 AA084248 Hs 85339 G protein-coupled rxeptor 39 253 274 393
437396 BE140396 Hs 21621 hypothetical protein DKFZp762O076 252 1 62 3 17
448140 AF146761 Hs 20450 BCM-like membrane protein precursor 251 267 1 88
442426 AI373062 Hs 332938 hypothedcal protein MGC5370 251 208 4 57
417427 M90391 Hs 82127 interieukin 16 (lymphxyte chemoattrxta 251 1 74 268
427581 NM 014788 Hs 179703 KIAA0129 gene product 251 1 67 2 24
432800 BE391046 Hs 278962 AIM-1 protein 251 555 242
408996 AI979168 Hs 344096 glycoprotein (transmembrane) nmb 250 1 95 241
410326 AI368909 Hs 47650 ESTs 250 285 263
452833 BE559681 Hs 30736 KIAA0124 protein 250 314 307
410016 AA297977 Hs 57907 small inducible cytokine subfamily A (Cy 249 338 291
429083 Y09397 Hs 227817 BCL2-related protein A1 248 1 85 270
418460 M26315 Hs 85258 CD8 andgen, alpha polypepdde (p32) 248 233 299
409142 AL136877 Hs 50758 SMC4 (structural mantenance of chromoso 247 1 88 414
412970 AB026436 Hs 177534 dual specificity phosphatase 10 246 200 098
401780 NM_005557* Homo sapiens keradn 16 (fxa 244 230 1 39
416426 AA180256 Hs 210473 Homo sapiens cDNA FU 14872 fis, clone PL 244 1 57 088
432606 NM 002104 Hs 3066 granzyme K (senne protease, granzyme 3, 242 1 91 256
417880 BE241595 Hs 82848 selxdn L (lymphocyte adhesion molxule 242 231 427
415929 AA724373 Hs 49344 hypothedcal protein FU11006 241 273 241
415752 BE314524 Hs 78776 putadve transmembrane protein 241 207 341
409703 NM 006187 Hs 56009 2-5-olιgoadenylate synthetase 3 (100 k 241 234 3 26
414004 AA737033 Hs 7155 ESTs, Moderately similar to 2115357A TYK 240 1 65 240
453857 AL080235 Hs 35861 DKFZP586E1621 protein 240 218 8 13
410290 AA402307 Hs 322844 hypothedcal protein DKFZp564A176 240 288 246
403328 Target Exon 239 200 1 95
427540 R12014 Hs 20976 ESTs 239 1 73 324
449523 NM 000579 Hs 54443 chemokine (C-C modf) rxeptor 5 239 1 96 239
433848 AF095719 Hs 93764 car oxypepddase A4 238 245 265
438501 Z44110 Hs 86149 phosphoinositol 3-phosphate-bιndιng prot 238 1 85 238
430066 AI929659 Hs 237825 signal recognidoπ particle 72kD 238 1 60 279
447343 AA256641 Hs 236894 ESTs, Highly simila to S02392 alpha-2 m 237 1 99 623
450447 AF212223 Hs 25010 hypothetical protein P152 237 1 72 324
458997 AW937420 ESTs 237 1 57 327
451446 AI826288 Hs 171637 hypothedcal protein MGC2628 235 1 90 2 39
408838 AI669535 Hs 40369 ESTs 235 1 59 271
448275 BE514434 Hs 20830 kinesm-like 2 235 2 19 235
424148 BE242274 Hs 1741 integnn, beta 7 235 1 89 307
410700 AA352335 Hs 65641 hypothedcal protein FLJ20073 235 1 65 235
409105 AW467539 Hs 255877 ESTs 235 250 235
452882 AW972990 Hs 196270 fblate transporter/earner 234 2 12 290
425606 U52112 Hs 158331 renin-bindmg protein 234 269 1 69
433576 BE080715 Hs 161091 ESTs 234 374 234
423494 AW504365 Hs 24143 Wiskott-Aldπch syndrome protein interx 234 208 448
431620 AA126109 Hs 264981 2-5'-olιgoadenylate synthetase 2 (69-71 233 243 266
436614 AW104388 Hs 149091 ESTs 233 337 233
425289 AW139342 Hs 155530 interferon, gamma- ducible protein 16 233 1 67 4 28
426827 AW067805 Hs 172665 methylenetetrahydrofolate dehydrogenase 233 1 58 040
430015 AW768399 ESTs 233 1 76 2 33
421282 AA286914 Hs 40782 ESTs 2 32 1 65 249
447737 AK000643 Hs 19404 DKFZP564L0862 protein 232 216 148
432540 AI821517 Hs 105866 ESTs 2 32 1 58 235
418064 BE387287 Hs 83384 S100 calcium-binding protein, beta (neur 232 246 999
414829 AA321568 Hs 77436 plxkstπn 232 1 91 232
425390 AI092634 Hs 156114 protein tyrosine phosphatase, noπ-rxept 231 1 63 231
448569 BE382657 Hs 21486 signal transducer and xdvator of trans 231 279 241
428819 AL135623 Hs 193914 KIAA0575 gene product 230 1 60 295
409512 AW979187 Hs 293591 melanoma differentiation assxiated prot 230 1 95 366
425231 AA527161 ESTs 228 1 96 236
416091 AF295370 Hs 283082 defensin, beta 3 228 276 218
418478 U38945 Hs 1174 cyclm-dependent kinase inhibitor 2A (me 2 27 288 246
427719 AI393122 Hs 134726 ESTs 227 1 88 229
431830 Y16645 Hs 271387 small inducible cytokine subfamily A (Cy 227 216 409
457465 AW301344 Hs 122908 DNA replication fxtor 226 2 23 226
431639 AK000680 Hs 266175 phosphoprotein assxiated with GEMs 2 26 2 13 3 16
442485 BE092285 Hs 29724 hypothetical protein FU13187 226 1 75 284
424687 J05070 Hs 151738 matnx metalloproteinase 9 (geladnase B 226 338 256
449317 AW293413 Hs 132906 19A24 protein 226 204 273
429922 Z97630 Hs 226117 H1 histone family, member 0 226 1 59 238
441362 8E614410 Hs 23044 RAD51 (S cerevisiae) homolog (E cdi Re 225 1 86 307
425388 AA329384 Hs 156110 immunoglobulin kappa constant 2 25 1 91 2 25
417282 AA195203 RAB5C, member RAS oncogene family 225 223 320
406687 M31126 matπx metalloproteinase 11 (stromelys 2 24 269 278
437862 AW978107 Hs 5884 Homo sapiens mRNA, cDNA DKFZp586C0224 (f 223 220 251
408015 AW136771 Hs 244349 epidermal differeπdadon ∞mplex protei 223 459 247
442503 AF147078 Hs 150853 p53-responsιve gene 5 223 362 085
429747 M87507 Hs 2490 caspase 1, apoptosis-related cysteine pr 2 22 1 60 1 69
424825 AF207069 Hs 153357 prxollagen-lysme, 2-oxoglutarate 5dιo 2 22 553 246
417693 AW959741 Hs 40368 adaptor-related protein complex 1 , sigma 221 240 437
422947 AA306782 Hs 122552 G-2 and S-phase expressed 1 221 206 232
445875 AF070524 Hs 13410 Homo sapiens clone 24453 mRNA sequence 220 269 291
417366 BE185289 Hs 1076 small prolme-nch protein 1B (cornifin) 220 226 379 450065 AL050107 Hs 24341 transcπpdonal co-xdvator with PDZ-bi 220 1 96 244
423397 NM 001838 Hs 1652 chemokine (C-C modf) receptor 7 220 328 299
427051 BE178110 Hs 173374 Homo sapiens cDNA FU10500 fis, clone NT 220 1 98 340
418203 X54942 Hs 83758 CDC28 protein kinase 2 220 1 44 231
409354 N68188 Hs 159472 Homo sapiens cONA FU22224 fis, done H 2 18 244 270
418941 AA452970 Hs 239527 E1B-55kDa-assocιated protein 5 218 1 75 270
424723 BE409813 Hs 152337 protein arginine N-methylfransferase 3(h 2 18 1 55 244
430132 AA204686 Hs 234149 hypothetical protein FU20647 218 1 3 237
452194 AI694413 Ubiquidn-like protein FAT10W - diubiq 2 17 307 1 76
417933 X02308 Hs 82962 Ihymidylate synthetase 2 17 1 86 4 15
420137 AA306478 Hs 95327 CD3D antigen, delta polypepdde (TιT3 co 217 238 291
425317 AW205118 Hs 210546 interieukin 21 rxeptor 2 17 202 2 22
447769 AW873704 Hs 320831 Homo sapiens cDNA FU14597 fis, clone NT 216 1 87 249
407748 AL079409 Hs 38176 KIAA0606 protein, SCN Orcadian Oscillat 216 1 55 226
452958 AA883929 Hs 40527 ESTs 215 1 56 284
440325 NM 003812 Hs 164 a dismtegnn and metalloproteinase doma 215 1 76 297
426153 AF057169 Hs 182771 vitelliform mxula dystrophy (Best dise 2 15 1 85 274
430580 AA806105 Hs 300697 immunoglobulin heavy constant gamma 3 (G 2 14 1 88 499
451952 AL120173 Hs 301663 ESTs 213 208 213
450534 AI570189 Hs 25132 KIAA0470 gene produd 2 12 1 67 341
449217 AA278536 Hs 23262 πbonuclease, RNase A family, k6 2 12 1 75 227
432734 AA837396 Hs 263925 LIS1-ιnteracdng protein NUDE1. rat homo 212 2 14 249
413190 AA151802 Hs 40368 adaptor-related protein complex 1, sigma 212 246 267
443991 NM 002250 Hs 10082 potassium intermediate/small conductance 212 216 282
429624 AA458648 Hs 99476 ESTs, Weakly simila to 1313184B alphal 2 11 201 068
447178 AW594641 Hs 192417 ESTs 210 252 210
423017 AW178761 Hs 227948 senne (or cysteine) proteinase inhibito 2 10 1 52 401
452110 T47667 Hs 28005 Homo sapiens cDNA FU11309 fis, clone PL 2 10 1 53 210
436797 AA731491 Hs 334477 hypothedcal protein MGC14879 210 1 55 241
453256 AI565587 Hs 32556 KIAA0379 protein 209 213 289
405547 NM.018833* Homo sapiens transporter 2, A 209 261 209
434203 BE262677 Hs 283558 hypothedcal protein PR01855 209 1 76 10
412609 Z48804 Hs 74124 xular albinism 1 (Nettleship-Falls) 209 391 238
414821 M63835 Hs 77424 Fc fragment of IgG, high affinity la, re 209 1 62 1 28
417576 AA339449 Hs 82285 phosphoπbosylglycmamide formyltransfer 208 1 86 208
447377 X77343 Hs 334334 transcnpdon fxtor AP-2 alpha 208 283 208
423198 M81933 Hs 1634 cell division cycle 25A 208 1 66 223
433068 NM 006456 Hs 288215 sialyltransferase 208 1 94 260
409038 T97490 Hs 50002 small inducible cytokine subfamily A (Cy 207 1 91 362
452392 L20815 Hs 507 corneodesmosin 207 396 097
403532 NM.024638 Homo sapiens hypothedcal prot 207 1 88 268
439859 AW292872 Hs 124554 ESTs 207 1 72 222
428484 AF104032 Hs 184601 solute earner family 7 (cationic ammo 207 226 4 22
442643 U82756 PRP4/STK/WD splicing fxtor 207 1 74 1 90
426312 AF026939 Hs 181874 interferon-induced protein with tetratn 206 208 1 43
409988 N27687 Hs 334334 transcnpdon fxtor AP-2 alpha (xdvat 206 2 12 206
408548 AA055449 Hs 63187 ESTs, Weakly similar to ALUC.HUMAN »" 206 1 65 291
442271 AF000652 Hs 8180 syndxan binding protein (syntenin) 206 1 97 242
414142 AW368397 Hs 334485 hemicendn (fibulin 6) 205 244 205
420931 AF044197 Hs 100431 small inducible cytokine B subfamily (Cy 205 2 37 205
450325 AI935962 Hs 91973 ESTs 205 1 67 1 82
424090 X99699 Hs 139262 XIAP assxiated fxtor-1 205 1 56 1 99
438209 AL120659 Hs 6111 aryl hydrocarbon rxeptor nuclear transl 204 1 52 207
413794 AF234532 Hs 61638 myosin X 204 202 211
414945 BE076358 Hs 77667 lymphxyte andgen 6 complex, Ixus E 204 4 57 1 64
425580 L11144 Hs 1907 galanm 204 1 67 226
420052 AA418850 Hs 44410 ESTs 203 1 90 221
415947 U04045 Hs 78934 mutS (E co ) homolog 2 (colon cancer, 203 1 53 231
416406 D86961 Hs 79299 lipoma HMGIC fusion partner-like 2 202 1 73 202
426759 AI590401 Hs 21213 ESTs 202 1 86 547
432435 BE218886 Hs 282070 ESTs 202 1 39 1 67
444184 T87841 Hs 282990 Human DNA sequence from clone RP1-28H20 202 1 57 202
421574 AJ000152 Hs 105924 defensin, beta 2 202 2 22 215
411358 R47479 Hs 94761 KIAA1691 protein 201 255 1 75
408209 NM 004454 Hs 43697 ets vanant gene 5 (ets-related molxule 201 258 239
409262 AK000631 Hs 52256 hypothedcal protein FU20624 201 1 50 201
400750 Target Exon 201 1 73 209
439496 BE616501 Hs 32343 Homo sapiens, Simila to RIKEN cDNA 1110 201 242 078
420460 AA262331 Hs 48376 Homo sapiens clone HB-2 mRNA sequence 201 1 65 1 2
446839 BE091926 Hs 16244 mitodc spindle coiled-coil related prot 201 1 61 1 03
427647 W19744 Hs 180059 Homo sapiens cDNA FU20653 fis, clone KA 200 211 233
436200 R51386 Hs 124881 ESTs 200 1 89 224
414175 AI308876 Hs 103849 hypothedcal protein DKFZp761D112 1 99 1 50 1 99
420005 AW271106 Hs 133294 ESTs 1 99 203 259
417848 AA206581 Hs 116586 ESTs. Weakly simila to JC5314 CDC28/cdc 1 99 1 42 217
435545 AA687415 Hs 28107 ESTs 1 99 1 89 1 99
443426 AF098158 Hs 9329 chromosome 20 open reading frame 1 1 99 2 23 344
444342 NM 014398 Hs 10887 simila to lysosome-assxiated membrane 1 99 205 032
453905 NM 002314 Hs 36566 LIM domain kinase 1 1 98 248 279
453884 AA355925 Hs 36232 KIAA0186 gene product 1 98 1 93 1 98
459373 BE408266 Hs 301406 hypothedcal protein PP3501 1 98 222 1 91
422809 AK001379 Hs 121028 hypothetical protein FLJ10549 1 98 1 68 1 98
452840 AI097393 Hs 43481 hypothedcal protein DKFZp564K192 198 1 67 218 409178 BE393948 Hs 50915 kallikrein 5 198 376 137
420991 AW504814 Hs 287379 Homo sapiens mRNA for FLJ0 111 protein, 198 190 263
414020 NM 002984 Hs 75703 small inducible cytokine A4 (homologous 197 188 123
443105 X96753 Hs9004 chondroidn sulfate proteoglycan 4 (mela 197 195 555
413450 Z99716 Hs 75372 N-xetylgalxtosamimdase, alpha- 197 177 197
431574 AW572659 Hs 261373 hypothetical protein dJ4340143 197 173 389
408561 AI308037 Hs 84120 hypothetical protein MGC13016 197 289 208
421866 M24470 Hs 1435 guanosine monophosphate reductase 197 195 265
405506 Target Exon 196 172 227
412490 AW803564 Hs 288850 Homo sapiens cDNA FLJ22528 fis, clone H 196 174 235
437379 AL359575 Hs 23765 Homo sapiens mRNA, cDNA DKFZp547M123 (fr 195 209 277
448356 AL120837 Hs 20993 high-glucose-regulated protein 8 195 166 258
453931 AL121278 Hs 25144 ESTs 195 238 195
424308 AW975531 Hs 154443 minichromosome maintenance deficient (S 195 163 282
429547 AW009166 Hs 99376 FGENESH predicted novel sxreted protein 194 202 135
442064 AI422867 Hs 88594 ESTs 194 149 221
400533 ENSP00000209376* PRED65 protein (Fragmen 194 169 194
448752 AA593867 Hs 300842 KIAA1608 protein 194 171 240
408636 BE294925 Hs 46680 CGI-12 protein 194 169 293
439569 AW602166 Hs 222399 CEGP1 protein 193 162 321
405779 NM.005367 Homo sapiens melanoma andgen, 193 183 199
444670 H58373 Hs 332938 hypothedcal protein MGC5370 193 197 193
446950 AA305800 Hs5672 hypothetical protein AF140225 193 156 161
409185 AW961601 Hs 252406 hypothedcal protein FU12296 similar to 193 212 263
409098 AA132672 Hs7984 pleckstnn homology, Sx7 and coiled/coi 192 212 251
413916 N49813 Hs 75615 apolipoprotein C-ll 192 198 022
429609 AFO02246 Hs 210863 cell adhesion molxule with homology to 192 165 639
402994 NM_002463* Homo sapiens myxovirus (influ 192 245 189
425722 AI659076 Hs 97031 hypothedcal protein MGC13047 192 269 230
421958 AA357185 Hs 109918 ras homolog gene family, member H 192 210 293
412584 X54870 Hs 74085 DNA segment on chromosome 12 (unique) 24 191 157 191
415402 AA164687 Hs 177576 manπosyl (alpha-1,3-)-glycoproteιπ beta- 191 144 168
430280 AA361258 Hs 237868 interieukiπ 7 rxeptor 190 152 114
426251 M24283 Hs 168383 intercellular adhesion molxule 1 (CD54) 190 216 121
440773 AA352702 Hs 37747 Homo sapiens, Similar to RIKEN cDNA 2700 190 184 207
427923 AW274357 Hs 301406 hypothedcal protein PP3501 190 426 170
426470 AA528794 Hs 128644 ESTs 190 269 204
409557 BE182896 Hs 3686 ESTs 190 201 190
429714 BE561801 HS2484 T-cell leukemia/lymphoma 1A 190 249 252
428125 AA393071 Hs 182579 leucine aminopeptidase 189 189 149
427634 AI399745 Hs 18449 hypothedcal protein MGC10820 189 359 171
452874 AK001061 Hs 30925 hypothedcal protein FU10199 189 167 145
418883 BE387036 Hs 1211 xid phosphatase 5, tartrate resistant 189 255 139
448243 AW369771 integnn, beta 8 189 196 189
416114 AI695549 Hs 183868 glucuronidase, beta 189 170 110
425935 Z98200 Hs 163724 HSPC019 protein 188 186 204
440672 AF083811 Hs 7345 MAD1 (mitodc arrest deficient, yeast, h 188 416 178
430171 AF086289 Hs 234766 skin-spxific protein 187 270 075
407366 AF026942 Hs 17518 gb Homo sapiens cιg33 mRNA, partial sequ 187 225 187
454294 AB000734 Hs 50640 JAK binding protein 187 198 146
417370 T28651 Hs 82030 tryptophanyl tRNA synthetase 187 273 171
409417 AA156247 Hs 104879 senne (or cysteine) proteinase mhibito 187 179 272
401781 Target Exon 187 188 116
440590 AI863446 Hs 266308 mosaic senne protease 186 179 113
428450 NM 014791 Hs 184339 KIAA0175 gene product 186 172 439
433675 AW977653 Hs 75319 nbonucleodde reductase M2 polypepdde 186 181 186
429323 NM 001649 Hs 2391 apical protein, Xenopus laevis-hke 186 157 186
433001 AF2Ϊ7513 Hs 279905 clone HQ0310PRO0310p1 185 171 582
453107 NM 016113 Hs 279746 vanilloid receptor-like protein 1 185 275 184
430441 BE398091 desmoplakin (DPI, DPII) 185 180 279
417512 X76534 Hs 82226 glycoprotein (transmembrane) πmb 185 180 186
423673 BE0O3054 Hs 1695 matπx metalloproteinase 12 (mxrophage 185 194 185
431958 X63629 Hs 2877 cadheπn 3, type 1 , P-cadheπn (plxeπta 185 172 252
414737 AI160386 Hs 125087 ESTs 184 190 184
439979 AW600291 Hs 6823 hypothetical protein FU 10430 184 157 184
428311 NM_005651 Hs 183671 tiyptophan 2,3-dιoxygenase 184 141 012
412141 AI183838 Hs 48938 hypothetical protein FU21802 184 170 315
428515 AF030339 Hs 286229 plexin C1 184 166 184
427914 AA417350 Hs 20575 ESTs 184 232 217
439352 BE61 347 Hs 169615 hypothedcal protein FU20989 184 155 184
413278 BE563085 Hs833 interferoπ-stimulated protein, 15 kDa 183 320 175
435080 AI831760 Hs 155111 hypothedcal protein FU14428 183 162 147
407966 AA295052 Hs 38516 Homo sapiens, clone MGC 15887, mRNA, com 183 158 211
421535 AB002359 Hs 105478 phosphonbosylformylglycinamidmesyntha 183 173 218
433029 NM 014322 Hs 279926 opsin 3 (encephalopsin) 183 196 183
426158 NM 001982 Hs 199067 v-erb-b2 avian erythroblastic leukemia v 183 161 246
426890 AA393167 Hs 1294 ESTs 182 244 182
411027 AF072099 Hs 67846 leukxyte immunoglobulm-like rxeptor, 182 224 201
441859 AW194364 Hs 94814 ESTs, Weakly similar to FIG1 MOUSE FIG-1 182 272 216
437435 AA249439 Hs 27027 hypothetical protein DKFZp762H1311 182 150 182
448357 N20169 Hs 108923 RAB38, member RAS oncogene family 182 252 176
420674 NM 000055 Hs 1327 butyrylcholinesterase 182 143 068
439219 N33883 Hs41322 ESTs 182 188 243 432810 AA863400 ESTs 182 143 182
417404 NM 007350 Hs 82101 plxkstnn homology-like domain, family 182 198 182
447484 AA464839 Hs 292566 hypothedcal protein FLJ14697 182 163 182
436456 AW292677 Hs 248122 G protein-coupled rxeptor 24 182 280 218
418918 X07871 Hs 89476 CD2 andgen (p50), sheep red blood cell 182 228 200
424755 AB033094 Hs 152925 KIAA1268 protein 182 185 162
436315 BE390513 Hs 27935 hypothedcal protein MGC4837 182 174 518
420783 AI659838 Hs 99923 Ixdn, galxtoside-bmding, sduble, 7 181 187 080
417105 X60992 Hs 81226 CD6 andgen 181 188 203
423961 D13666 Hs 136348 peπosdn (OSF-2os) 181 173 245
446019 AI362520 histone dexetylase 3 181 139 224
412580 AA113262 Hs 17901 Homo sapiens, clone IMAGE 3937015, mRNA, 181 305 158
409415 AA579258 Hs 6083 Homo sapiens cDNA FU21028 fis, clone C 180 200 178
453684 AK001922 Hs 34578 alpha2,3-sιalyltransferase 180 198 122
446921 AB012113 Hs 16530 small inducible cytokine subfamily A (Cy 180 156 171
453779 N35187 Hs 43388 28kD interferon responsive protein 180 242 204
434706 AI656291 Hs 116394 ESTs 180 158 180
416065 BE267931 Hs 78996 proliferating cell nuclear andgen 180 179 251
453331 AI240665 ESTs 179 143 233
429412 NM 006235 Hs 2407 POU domain, class 2 assxiadng fxtor 179 146 446
428784 Y12851 Hs 193470 punnergic receptor P2X ligand-gated 10 179 230 179
453507 AF083217 Hs 33085 WD repeat domain 3 179 149 151
452826 BE245286 Hs 301636 peroxisomal biogenesis fador 6 179 157 200
439237 AW408158 Hs 318893 ESTs, Weakly similar to A47582 B-cell gr 179 226 2.22
406672 M26041 Hs 198253 major histocompatibility complex, class 179 176 178
431009 BE149762 Hs 48956 gap junction protein, beta 6 (connexm 3 179 1 3 332
452698 NM 001295 Hs 301921 chemokine (C-C modf) rxeptor 1 178 166 129
424954 NM 000546 Hs1846 tumor protein p53 (ϋ-Fraumem syndrome) 178 173 235
436378 AJ227874 Hs 99244 ESTs 178 184 178
421778 AA428000 Hs 283072 xtm related protein 2/3 complex, subun 178 166 367
421948 L42583 Hs 334309 keradn 6A 178 174 300
414915 NM_002462 Hs 76391 myxovirus (influenza) resistance 1, homo 177 227 213
437317 AA748613 Hs 311977 ESTs, Highly similar to SWI/SNF related 177 198 232
427318 AF186081 Hs 175783 zinc transporter 177 161 092
418403 D86978 Hs 84790 KIAA0225 protein 176 149 224
421433 AI829192 Hs 22380 ESTs 176 149 252
450728 AW162923 Hs 25363 presenilin 2 (Alzheimer disease 4) 176 174 176
428655 H05769 Hs 188757 Homo sapiens, clone MGC 5564, mRNA, comp 176 143 176
427536 BE277141 Hs 115803 gb 601178666F1 NIH.MGC_20 Homo sapiens c 176 212 176
433364 AI075407 Hs 296083 ESTs, Moderately similar to I54374 gene 1 6 186 148
401994 Target Exon 175 144 175
418299 AA279530 Hs 83968 integnn, beta 2 (antigen CD18 (p95), ly 175 169 179
408633 AW963372 Hs 46677 PRO2000 protein 175 146 188
429978 AA249027 πbosomal protein S6 175 160 192
450690 AA296696 Hs 333418 FXYD doman-contanmg ion transport reg 175 213 203
456967 AW004056 Hs 168357 T-box2 174 195 142
417866 AW067903 Hs 82772 collagen, type XI, alpha 1 174 264 201
428746 AW503820 Hs 192861 Spi-B transcnpdon fxtor (Spι-1/PU 1 r 174 282 231
432642 BE297635 Hs 3069 heat shxk 70kD protein 9B (mortalιn-2) 174 151 162
429505 AW820035 Hs 278679 a dismtegnn and metalloproteinase doma 173 154 315
412851 AI826502 Hs 97269 ESTs 173 167 105
453953 AW408337 Hs 36972 C07 andgen (p41) 173 222 228
430413 AW842182 Hs 241392 small inducible cytokine A5 (RANTES) 173 205 147
419485 AA489023 Hs 99807 ESTs Weakly similar to unnamed protein 173 171 1 3
447217 BE465754 Hs 17778 neuropilin 2 173 162 470
437673 AW665665 Hs 153034 ESTs 172 155 210
437879 BE262082 Hs5894 hypothedcal protein FU10305 172 250 180
448410 AK000227 HS21126 hypothedcal protein FU20220 172 148 398
413313 NM 002047 Hs 283108 glycyl-tRNA synthetase 172 219 182
452203 X57522 transporter 1 , ATP-bindmg cassette, sub 172 268 168
443950 NM.001425 Hs9999 epithelial membrane protein 3 171 217 224
403969 ENSP00000034663 Zinc finger protein 131 171 131 171
450832 AW970602 Hs 105421 ESTs 171 133 238
453005 AW055308 Hs 31803 ESTs, Weakly similar to N-WASP [H sapien 171 167 195
439783 AI125760 Hs 24835 hypothedcal protem FU 14594 171 210 220
418678 NM 001327 Hs 167379 cancer/tesds antigen (NY-ESO-1) 171 386 176
432259 BE269103 Hs 274201 60S xidic nbosomal protein PO 171 185 194
420340 NM 000734 Hs 97087 CD3Z antigen, zeta polypepdde (TιT3com 171 212 198
428289 M26301 Hs 2253 complement component 2 171 246 076
424006 AF054815 Hs 137548 CD84 antigen (leukocyte antigen) 170 170 278
440039 Z46188 Hs 6874 KIAA0472 protein 170 224 160
406646 M33600 Hs 308026 major histocompatibility complex, class 170 227 133
425367 BE271188 Hs 155975 protein tyrosine phosphatase, rxeptor t 170 277 207
420286 AI796395 Hs 111377 ESTs 170 150 321
430255 AK000703 Hs 323822 Homo sapiens mRNA for KIAA1551 protein, 169 144 169
445247 AW274290 Hs 153997 ESTs 169 257 165
436965 Z11894 Hs 156110 gb H sapiens rearranged mRNA for immunog 169 152 313
410257 BE244044 Hs 61469 hypothetical protein 169 199 197
424663 NM 002351 Hs 151544 SH2 domain protein 1A, Duncan's disease 169 176 169
427792 M63928 Hs 180841 tumor nxrosis fxtor rxeptor superfami 169 198 248
458098 BE550224 metallothione 1E (functional) 168 183 168
425397 J04088 Hs 156346 topoisomerase (DNA) II alpha (1 0kD) 168 157 409
421485 AA243499 Hs 104800 hypothetical protein FU10134 168 164 068 421563 NM 006433 Hs 105806 granulys 168 224 155
448775 AB025237 Hs388 nudix (nucleoside diphosphate linked moi 168 198 205
451418 BE387790 Hs 26369 hypothedcal protein FU20287 168 135 168
440457 BE387593 Hs 21321 Homo sapiens clone FLB9213 PR02474 mRNA, 168 188 163
438866 U44385 Hs 325495 dssue inhibitor of metalloproteinase 2 167 254 190
401760 Target Exon 167 193 161
422158 L10343 Hs 112341 protease inhibitor 3, skin-deπved (SKAL 167 185 425
446644 NM 003272 Hs 15791 transmembrane 7 superfamily member 1 (up 167 194 148
415701 NM 003878 Hs 78619 gamma-glutamyl hydrolase (conjugase, fol 167 165 090
450293 N36754 Hs 171118 hypothedcal protein FU00026 167 154 195
412856 BE386745 Hs 74631 basigm (OK blood group) 167 271 147
439318 AW837046 Hs 6527 G protein-coupled rxeptor 56 166 182 119
424399 AI905687 AI905687 IL-BT095190199-019 BT095 Homo 166 365 044
432355 AA534416 Hs 162185 ESTs, Weakly similar to S42799 garp prx 166 198 145
427239 BE270447 ubiquitin earner protein 166 294 192
425262 087119 Hs 155418 GS3955 protein 166 236 166
413869 NM 000878 Hs 75596 interieukin 2 rxeptor, beta 166 186 190
406698 X03068 Hs 73931 major histocompatibility ∞mplex, class 165 205 131
446217 AI651594 Hs 99709 ESTs 165 198 177
400222 NM_002082* Homo sapiens G protein-couple 165 174 181
432468 AW402155 Hs3003 CD3E antigen, epsilon polypepdde (TιT3 165 250 177
417237 H86385 Hs 81737 palmitoyl-protein thioesterase 2 165 289 157
433012 NM 004045 Hs 279910 ATX1 (andoxidant protein 1, yeast) homo 164 276 126
446291 BE397753 Hs 14623 interferon, gamma-inducible protein 30 164 196 124
433867 AK000596 Hs 3618 hippocalcm-like 1 164 147 100
433671 AW138797 Hs 132906 19A24 protein 164 217 196
418371 M13560 Hs 84298 CD74 andgen (mvanant polypeptide of m 164 218 143
432336 NM 002759 Hs 274382 protein kinase, interferon-inducible dou 164 147 164
409264 NM 014937 Hs 52463 KIAA0966 protein 164 146 489
431836 AF178532 Hs 271411 beta-site APP-cleaving enzyme 2 164 258 179
414586 AA306160 Hs 16488 lymphxyte cytosolic protein 1 (L-plasd 163 172 188
418117 AI922013 Hs 83496 linker for xdvadon of T cells 163 198 199
448304 BE622768 Hs 290356 mesoderm development candidate 1 163 167 186
425535 AB007937 Hs 158287 KIAA0468 gene product 163 256 197
453258 AW293134 Hs 32597 ππg finger protein (C3H2C3 type) 6 163 146 243
420000 AB036063 Hs 94262 p53-ιnducιble nbonucleodde reductase s 163 134 194
447321 AW271217 Hs 281434 Homo sapiens cDNA FU 14028 fis, one HE 163 196 177
422192 AA305159 Hs 113019 fls485 162 145 162
450701 H39960 Hs 288467 hypothedcal protein XP_098151 (leucme- 162 223 153
419381 AB023420 Hs 90093 heat shxk 70kD protein 4 162 157 238
424779 AL046851 Hs 153053 CD37 antigen 162 192 210
413283 R78669 Hs 23756 hypothedcal protein similar to swine x 162 141 112
414907 X90725 Hs 77597 polo (Drosophιa)-lιke kinase 162 203 213
414159 AW511414 Hs 257352 apolipoprotein L, 6 162 189 132
410055 AJ250839 Hs 58241 gene for seπne/threoπine protein kinase 162 181 127
428179 AI127772 Hs 279696 serum/glucccorticoid regulated kmase-li 162 150 213
436251 BE515065 Hs 296585 nucleolar protein (KKE/D repeat) 161 171 202
451708 AI306536 Hs 60975 ESTs 161 231 170
418113 AI272141 Hs 83484 SRY (sex determining region Y)-box 4 161 153 250
410600 AW575742 ESTs, Moderately similar lo S65657 alpha 161 183 169
436873 N23874 Hs 50477 RAB27A member RAS oncogene family 161 156 161
440201 AL359588 Hs 7041 hypothetical protein DKFZp762B226 161 158 185
414368 W70171 Hs 75939 undine monophosphate kinase 161 159 275
454429 BE273437 Hs 301406 hypothedcal protein PP3501 161 354 152
422257 NM 001716 Hs 113916 Burkitt lymphoma rxeptor 1, GTP-binding 161 215 154
426437 BE076537 Hs 169895 ubiquidn-coniugadng enzyme E2L 6 160 201 136
408826 AF216077 Hs 48376 Homo sapiens clone HB-2 mRNA sequence 160 200 160
414761 AU077228 Hs 77256 enhancer of zeste (Drosophila) homolog 2 160 138 223
429612 AF062649 Hs 252587 pituitary tumor-transforming 1 160 178 259
411263 BE297802 Hs 69360 kinesm-like 6 (mitodc centromere-assx 160 178 207
417324 AW265494 ESTs 160 248 191
430325 AF004562 Hs 239356 syntaxin binding protein 1 160 174 253
431797 BE169641 Hs 270134 hypothedcal protein FU20280 160 146 246
434449 AW953484 Hs 3849 hypothetical protein FU22041 similar to 160 181 300
443378 AW392550 Hs9280 proteasome (prosome, mxropain) subunit, 159 188 168
417437 U52682 Hs 82132 interferon regulatory fxtor 4 159 190 226
437949 U78519 Hs 41654 ESTs, Weakly similar to A46010 X-linked 159 214 159
401797 Target Exon 159 182 178
449720 AA311152 Hs 288708 hypothedcal protein FU21562 159 145 469
424971 AA479005 Hs 154036 tumor suppressing subtransferable candid 159 182 168
415474 NM_014252 Hs 78457 solute earner family 25 (mitxhondπal 158 151 030
430017 AA263172 Hs35 protein tyrosine phosphatase, non-rxept 158 172 246
422515 AW500470 Hs 117950 multifunctional polypepdde simila to S 158 185 194
434094 AA305599 Hs 238205 hypothedcal protein PRO2013 158 125 209
428844 AW972635 Hs 301904 hypothetical protein FU12671 158 172 180
440942 AW246547 Hs 17901 Homo sapiens, clone IMAGE 3937015, mRNA, 158 260 158
419596 BE379320 Hs 91448 MKP-1 like protein tyrosine phosphatase 158 184 122
401151 Target Exon 158 243 160
441590 AI623207 Hs 190537 ESTs 158 140 158
418677 S83308 Hs 87224 SRY (sex determining region Y)-box 5 158 168 158
416448 L13210 Hs 79339 Ixdn, galxtoside-binding, soluble, 3 158 228 160
418739 AA310964 Hs 88012 SHP2 interxdng transmembrane adaptor 158 214 210
418216 AA662240 Hs 283099 AF15q14 protein 157 146 157 427700 AA262294 Hs 180383 dual specificity phosphatase 6 157 142 088
436485 X59135 Hs 156110 immunoglobulin kappa constant 157 149 269
404872 ENSP0OO00243173* DJ1109J221 (novel home 157 146 136
408212 AA297567 Hs 43728 hypothedcal protein 157 155 273
414699 AI815523 Hs 76930 synuclein, alpha (non A4 component of am 157 136 157
444006 BE395085 Hs 10086 type I transmembrane protein Fn14 157 170 113
432946 U60899 Hs 279854 mannosidase, alpha, class 2B, member 1 157 175 157
417929 R27219 Hs 74647 Human T-cell rxeptor xdve alpha-chain 157 226 210
431629 AU077025 Hs 265827 interferon, alpha-mducible protein (do 157 209 157
402876 NM.022161' Homo sapiens dvin inhibitor- 156 228 1 5
439627 BE621702 Hs 29076 hypothetical protein FU21841 156 297 154
414839 X63692 Hs 77462 DNA (cytosine 5)-methyltransferase 1 156 175 188
450663 H43540 Hs 25292 ribonuclease HI, lage subunit 156 276 167
425818 AB021225 Hs 159581 matπx metalloproteinase 17 (membrane-in 156 236 183
422765 AW409701 Hs 1578 bxuloviral IAP repeat-containing 5 (sur 156 178 206
456508 AA502764 Hs 123469 ESTs, Weakly similar to AF2088551 BM-01 156 132 270
453613 F06838 ESTs 156 176 184
428379 X06026 Hs 2259 CD3G andgen, gamma polypepdde (TιT3 co 156 143 156
429500 X78565 Hs 289114 hexabrxhion (tenascin C, cytotacdn) 156 147 315
444652 BE513613 Hs 11538 xdn related protein 2/3 complex, subun 156 201 156
420842 AI083668 Hs 50601 hypothedcal protein MGC10986 155 224 190
447513 AW955776 Hs 313500 ESTs, Moderately similar to ALU7_HUMAN A 155 124 307
408901 AK001330 Hs 48855 hypothedcal protein FU 10468 155 179 217
437669 AI358105 Hs 123164 ESTs, Weakly similar to match to ESTs AA 155 183 196
439437 AI207788 Hs 343628 sialyltransferase 4B (beta-galactosidase 155 163 220
418835 AL023694 Hs 88977 hypothedcal protein dJ511E162 155 173 150
448633 AA311426 Hs 21635 tubulin, gamma 1 154 202 167
447763 BE619911 Hs 115803 hypothedcal protein 154 252 152
430223 NM 002514 Hs 235935 nephroblastoma overexpressed gene 154 154 303
448258 BE386983 Hs 343214 hypothetical protein FLJ20396 154 197 153
440165 AW014718 Hs 7753 calumenm 154 153 255
433376 AI249361 Hs 74122 caspase 4, apoptosis-related cysteine pr 154 134 169
445982 BE410233 Hs 13501 pescadilto (zebrafish) homolog 1, conta 154 221 154
419741 NM 007019 Hs 93002 ubiquitin earner protein E2-C 154 250 194
416926 H03109 Hs 263395 HT018 protein 154 141 201
431630 NM 002204 Hs 265829 integnn, alpha 3 (antigen CD49C, alpha 154 189 123
442159 AW163390 Hs 278554 heterxhromadn-like protein 1 154 193 179
420421 AF281133 Hs 343589 exosome component Rrp41 153 247 161
406973 M34996 Hs 198253 major histocompatibility complex, class 153 162 119
422530 AW972300 Hs 118110 bone marrow stromal cell andgen 2 153 174 137
423420 AI571364 Hs 128382 Homo sapiens mRNA, cDNA DKFZp761M224 (f 153 249 159
429359 W00482 Hs 2399 matπx metalloproteinase 14 (membrane-in 153 272 154
429837 NM 003896 Hs 225939 sialyltransferase 9 (CMP-NeuAc Ixtosylc 153 164 240
412939 AW411491 Hs 75069 eukaiγodc transladon elongation fxtor 152 198 098
410678 BE540516 Hs 293732 hypothetical protein MGC3195 152 139 217
431186 NM.012249 Hs 250697 ras-like protein 152 191 182
406868 AA505445 Hs 300697 immunoglobulin heavy constant gamma 3 (G 152 157 182
422532 AL008726 Hs 118126 protxdve protein for beta-galxtosidas 151 208 119
413063 AL035737 Hs 75184 chidnase 3-lιke 1 (cartilage gly∞prote 151 150 067
417308 H60720 Hs 81892 KIAA0101 gene product 151 142 741
424902 NM.003866 Hs 153687 inositol polyphosphate-4-phosphatase, ty 151 275 151
405204 NM_002086* Homo sapiens growth fxtor re 151 144 153
424481 R19453 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbx 151 192 232
422516 BE258862 Hs 117950 muldfuncdonal polypeptide similar to S 150 161 147
418827 BE327311 Hs 47166 HT02I 150 135 353
427550 BE242818 Hs 311609 nuclear RNA helicase, DECD vanant of DE 150 155 209
432992 BE270472 Hs 279900 HSPC015 protein 150 182 082
442432 BE093589 Hs 38178 hypothetical protein FU23468 150 134 487
413566 AW604451 Hs 285814 sprouty (Drosophila) homolog 4 150 305 151
422616 BE300330 Hs 118725 selenophosphate synthetase 2 150 136 046
431222 X56777 Hs 273790 zona pellucida glycoprotein 3A (sperm re 150 205 178
421861 S78798 Hs 108966 phosphatidylmositol-4-phosphate kinas 149 152 262
422684 BE561617 Hs 119192 H2A histone family, member Z 149 153 202
452363 AI582743 Hs 94953 Homo sapiens, Similar to complement comp 149 202 141
411825 AK000334 hypothetical protein FLJ20327 149 255 138
409425 U40462 Hs 54452 zinc finger protein, subfamily 1 A, 1 (Ik 149 177 149
431070 AW408164 Hs 249184 transcnpdon fxtor 19 (SC1) 149 179 175
427080 AW068287 Hs 301175 ras-related C3 botulmum toxin substrate 1 9 157 214
440676 NM 004987 Hs 112378 LIM and senescent cell antigen-like doma 149 142 146
411296 BE207307 Hs 10114 growth suppressor 1 149 174 150
442894 W02112 Hs 8836 parv beta 149 225 151
416361 AW204907 Hs 6872 ESTs, Weakly similar to CA13.HUMAN COLLA 1 9 206 189
424162 AA336229 Hs 93135 ESTs Weakly similar to ALU2.HUMAN ALU S 149 159 165
447131 NM 004585 Hs 17466 retinoic xid rxeptor responder (tazaro 149 200 122
427759 BE245578 Hs2200 perfonn 1 (pore forming protein) 149 212 141
422846 BE513934 Hs1583 neutrophil cytosolic fxtor 1 (47kD, chr 149 161 167
417007 AF224741 Hs 80768 chloride channel 7 148 194 171
421924 BE514514 Hs 109606 coronin, xtin-bind g protein, 1A 148 168 167
422241 Y00062 Hs 170121 protein tyrosine phosphatase, rxeptor t 148 143 225
410741 Z11695 Hs 324473 mitogen-xdvated protein kinase 1 148 137 317
447471 AF039843 Hs 18676 sprouty (Drosophila) homolog 2 148 135 146
427247 AW504221 Hs 174103 integnn alpha L (antigen CD11 A (p180), 1 7 158 148
442945 AI024849 Hs 131853 ESTs 147 173 138 447200 BE543146 Hs 281434 Homo sapiens cDNA FU 14028 fis, ctone HE 147 189 160
424085 NM 002914 Hs 139226 replicadoπ fxtor C (xdvator 1) 2 (40 147 203 147
422867 L32Ϊ37 Hs1584 cartilage odgomeπc matπx protein (pse 147 186 193
416350 AF188625 Hs 189507 phospholipase A2, group HD 147 292 149
458207 T28472 Hs 7655 U2 small nuclear πbonucleoprotein auxil 147 161 173
447940 086982 Hs 20060 KIAA0229 protein 147 193 172
446106 AA377165 Hs 44833 ESTs 147 156 163
425811 AL039104 Hs 159557 karyophenn alpha 2 (RAG cohort 1, irnpor 147 178 184
432615 AA557191 Hs 55028 ESTs, Weakly simila to 154374 gene NF2 147 204 147
435099 AC004770 Hs 4756 flap structure-spxific endonuclease 1 147 176 183
402294 Target Exon 147 127 1 6
430147 R60704 Hs 234434 hary/enhancer-of-split related with YRP 146 200 159
414324 Y14768 Hs890 lymphotoxin beta (TNF superfamily, membe 146 158 215
400270 NM_000026* Homo sapiens adenytosuαinate 146 142 232
414806 014694 Hs 7329 phosphaddylseπne synthase 1 146 207 140
419625 U91616 Hs 182885 nuclea fxtor of kappa light polypepdd 145 178 153
430594 AK000790 Hs 246885 hypothedcal protein FU20783 145 131 090
419556 U29615 Hs 91093 chidnase 1 (chitotnosidase) 145 213 146
453350 AI917771 Hs 61790 hypothetical protein FU23338 145 200 139
448412 AI219083 Hs 42532 ESTs, Moderately similar to ALU8_HUMAN A 145 137 317
411619 AI418609 Hs 71040 hypothetical protein FLJ20425 145 139 301
424218 AF031824 Hs 143212 cystadn F (leukocystadn) 145 182 144
450395 BE048545 Hs 161757 ESTs 145 240 133
438555 AI222089 Hs 143878 Homo sapiens mRNA for FU00024 protein. 145 191 165
422497 D29642 Hs 1528 KIAA0053 gene product 145 194 149
400991 Target Exon 145 210 142
431779 AW971178 Hs 268571 apolipoprotein C-l 145 153 042
424618 L29472 Hs 1802 major histocompadbility complex, class 144 196 186
423032 AI684746 Hs 119274 f!AS p21 protein xdvator (GTPase xdva 144 134 336
424232 AB015982 Hs 143460 protein kinase C, nu 144 128 294
438291 BE514605 Hs 289092 Homo sapiens cDN A FLJ 22380 fis, clone H 144 163 145
445745 AB007924 Hs 13245 KIAA0455 gene pro uct 144 117 152
449209 BE616830 Hs 294145 ESTs 144 135 248
410129 BE244074 Hs 58831 regulator of Fas-induced apoptosis 144 210 179
401284 Target Exon 144 171 144
422675 BE018517 Hs 119140 eukaryodc translation initiation fxtor 144 168 145
433020 AI375726 Hs 279918 hypothedcal protein 144 137 202
420042 AW0151 0 Hs 161723 ESTs 144 202 129
453878 AW964440 Hs 19025 DC32 144 169 144
427268 X78520 Hs 174139 chlonde channel 3 144 145 196
417386 AL037228 Hs 82043 D123 gene product 143 132 281
409197 N54706 Hs 303025 chromosome 11 open reading frame 24 143 180 117
411009 W37572 Hs 285864 ESTs 143 157 172
433160 AW207002 Hs 134342 TASP for tesds-spxific adπamycm sens 1 3 136 149
416084 L16991 Hs 79006 deoxythymidylate kinase (thymidylate kin 143 215 157
407826 AA128423 Hs 40300 calpam 3, (p94) 1 3 161 169
439070 AI733278 Hs 7621 ESTs 143 210 140
444090 S69115 Hs 10306 natural killer cell group 7 sequence 143 209 124
420162 BE378432 Hs 95577 cyclin-dependent kinase 4 143 213 154
442591 AW292797 hypothedcal protein MGC10772 1 3 211 161
451668 Z43948 Hs 326444 cartilage xidic protein 1 143 149 116
423639 AB037826 Hs 130411 KIAA1405 protein 142 208 151
426234 BE31 534 Hs 168159 apoptosis regulator 142 157 131
424263 M77640 Hs 1757 L1 cell adhesion molxule (hydrocephalus 142 188 163
430294 AI538226 Hs 32976 guanine nudeodde binding protein 4 1 2 146 318
447126 AW150632 Hs 170307 Ral guanine nudeodde exchange fxtor R 142 136 138
432241 AI937060 Hs6298 KIAA1151 protem 142 158 198
412471 M63193 Hs 73946 endothelial cell growth fxtor 1 (platel 141 209 129
434262 AF121858 Hs 12169 sorting nexm 8 141 307 141
432238 AL133057 Hs 274135 Homo sapiens mRNA, cDNA DKFZp434K1815 (f 141 182 143
402474 NM.004079 Homo sapiens cathepsin S (CTSS 141 132 124
419897 X90826 Hs 93649 upstream transcnpdon fxtor 2, c-fos i 141 169 180
417621 AV654694 Hs 82316 interferon induced hepadds C-assxiat 141 122 174
424441 X14850 Hs 147097 H2A histone family, member X 141 174 215
406663 U24683 immunoglobulin heavy constant mu 141 151 203
409614 BE297412 Hs 55189 hypothedcal protein 141 154 220
443885 H91806 Hs 15284 ESTs 141 119 141
412276 BE262621 Hs 73798 mxrophage migration inhibitory fxtor ( 140 188 124
425179 AJ224442 Hs 155020 putadve methyltransferase 140 184 147
418699 BE539639 Hs 173030 ESTs, Weakly similar to ALU8 HUMAN ALU S 140 127 279
432403 AA550815 Hs 124840 ESTs 140 183 144
417389 BE260964 Hs 82045 midkine (neurite growth-promodng fxtor 140 165 251
422596 AF063611 Hs 118633 2-5'-olιgoadenylatesynthetase-lιke 140 257 144
435292 N20514 Hs 172965 ESTs 140 191 143
419424 BE041820 Hs 38516 Homo sapiens clone MGC 15887, mRNA, com 139 157 137
425068 AL048716 Hs 154387 KIAA0103 gene product 139 127 318
426020 AL110195 Hs 166017 microphthalmia-assxiated transcnpdon 139 226 140
427740 BE242604 Hs 180616 CD36 andgen (collagen type I rxeptor, 139 176 099
403022 C21000178' gι|7341207|gb|AAF612151|AF22 139 174 136
416111 AA033813 Hs 79018 chromatin assembly fxtor 1 , subunit A ( 139 172 139
410103 AW903666 gb CM4-NN1032-280300-122-M.2 NN1032 Homo 139 146 134
439180 AI393742 Hs 199067 v-ert3-b2 avian erythroblastic leukemia v 139 135 179
414057 AI815559 Hs 75730 signal recognidon particle receptor fd 139 1 9 117 416511 NM 006762 Hs 79356 Lysosomal-assxiated muldspann g membr 139 152 144
423984 AF163825 Hs 136713 pre-B lymphxyte gene 3 139 302 152
448484 8E613340 Hs 334725 Homo sapiens, Similar to RIKEN cDNA 9430 138 181 139
436856 AI469355 Hs 127310 ESTs 138 135 099
437179 AA393508 serologically defined colon cancer andg 138 126 414
437912 8E278594 Hs 5912 F-box only protein 7 138 203 140
448664 AI879317 Hs 334691 splicing fxtor 3a. subunit 1, 120k0 138 152 138
439981 AI348408 Hs 124675 ESTs, Weakly simila to T 14742 hypotheti 138 148 138
432812 AI935412 Hs 50162 ESTs 138 143 218
406826 AW516005 Hs 84298 CD74 andgen (mvanant polypepdde of m 138 187 128
446962 AI351421 Hs 279709 muscle specific πng finger protein 1 138 146 223
408787 NM 014784 Hs 47822 Rho guanine exchange fxtor (GEF) 11 138 198 150
428044 AA093322 Hs 301404 RNA binding modf protein 3 138 129 204
412926 AI879076 Hs 75061 macrophage myπstoylated alan e-πch C 138 152 262
418255 AW135405 Hs 37251 ESTs 138 144 175
419745 AF042001 Hs 93005 slug (chicken homolog), zinc finger prof 137 151 137
448977 X91809 Hs 22698 regulator of G-protem signalling 19 137 198 145
422609 Z46023 Hs 118721 sialidase 1 (lysosomal sialidase) 137 175 131
435458 F11872 Hs4892 Homo sapiens ctone 24841 mRNA sequence 137 138 280
425081 X74794 Hs 154443 minichromosome maintenance deficient (S 137 161 162
429849 U33053 Hs2499 protein kinase C-like 1 137 171 145
407103 AA424881 Hs 256301 hypothedcal protein MGC13170 137 162 182
452923 BE276018 Hs 288940 five-span transmembrane protein M83 137 186 137
453941 U39817 Hs 36820 Bl∞m syndrome 137 159 137
446755 AW451473 Hs 16134 seπne/threonine kinase 10 137 182 148
439755 AW748482 Hs 77873 87 homolog 3 136 210 135
447630 AI660149 Hs 44865 lymphoid enhancer-binding fxtor 1 136 179 167
413821 AA844126 Hs 55964 ESTs, Weakly simila to C4HU complement 136 191 139
445823 AI478563 Hs 145519 FKSG87 protein 136 129 033
456760 AW961251 Hs 127828 guanine nucleotide binding protein (G pr 136 133 201
402542 Target Exon 136 166 146
451050 AW937420 ESTs 136 200 136
444501 AW247624 Hs 11342 ninjuπn 1 136 159 114
413291 NM_006278 Hs 75268 sialyltransferase 4C (beta-galxtosidase 136 255 142
438129 AA778647 gb af87d03 s1 Soaes tesds NHT Homo sap 136 146 132
428398 AI249368 Hs 98558 ESTs 136 125 495
439704 AW020018 Hs 293267 ESTs 136 184 148
428782 X12830 Hs 193400 interieukin 6 receptor 136 127 058
437316 AI683454 Hs 46801 GCN5 (general control of amino-xid synt 135 210 129
439246 AI498072 membrane-associated tyrosine- and threon 135 181 163
403409 NM.005929 Homo sapiens andgen p97 (mela 135 164 135
446342 BE298665 Hs 14846 Homo sapiens mRNA, cDNA DKFZp564D016 (fr 135 137 233
437740 AA810265 Hs 122915 ESTs 135 191 135
423973 AF038461 Hs 136574 arxhidonate 12-lιpoxygenase 12R type 135 153 110
421506 BE302796 Hs 105097 thymidine kinase 1 , soluble 135 189 157
457760 AA668123 Hs 134170 ESTs 135 203 143
439769 AA448828 Hs 30596 Homo sapiens mRNA full length insert cDN 135 206 1 1
406824 AW515961 Hs 84298 CD74 andgen (mvanant polypepdde of m 135 177 127
429852 AB010445 Hs 225948 small inducible cytokine subfamily A (Cy 135 152 051
421777 BE562088 Hs 108196 HSPC037 protein 134 165 161
400328 X87344 transporter 2, ATP-bindmg cassette, sub 134 177 102
421445 AA913059 Hs 104433 Homo sapiens, clone IMAGE 4054868, mRNA 134 1 7 115
428977 AK001404 Hs 194698 cyclm B2 134 153 182
418283 S79895 Hs 83942 cathepsin K (pycnodysostosis) 134 133 345
425848 BE242709 Hs 159637 valyl-tRNA synthetase 2 134 211 132
431211 M86849 Hs 323733 gap juncdon protein, beta 2, 26kD (conn 134 127 197
422758 AF152329 Hs 284180 protxxtan gamma subfamily C, 3 134 161 175
421579 NM 002975 Hs 105927 stem cell growth fxtoπ lymphxyte sxr 134 175 181
416374 NM 001154 Hs 300711 annexin A5 134 168 155
451092 AI207256 Hs 13766 Homo sapiens mRNA for FU00074 protein, 134 187 081
424778 AA251048 Hs 153042 lymphxyte antigen 9 134 194 142
421703 AI936513 Hs 1416 Fc fragment of IgE, low affinity II, rx 133 219 148
416700 AW498958 Hs 343475 cathepsin D (lysosomal aspartyl protease 133 196 118
425923 NM 005026 Hs 162808 phosphoιnosιtιde-3-kιπase, catalytic, de 133 170 160
418803 U50079 Hs 88556 histone dexetylase 1 133 128 265
427730 AW250549 Hs 180577 granulm 133 209 135
441174 BE312775 Hs 294005 Homo sapiens, clone IMAGE 3050476, mRNA, 133 205 133
412738 N34731 Hs 74562 siah binding protein 1 FBP interxdng 133 185 135
424528 AW073971 Hs 238954 ESTs, Weakly similar to KIAA1204 protein 133 131 206
422599 BE387202 Hs 118638 non-metastadc cells 1. protein (NM23A) 133 177 143
422997 BE018212 Hs 122908 DNA replication fxtor 133 191 139
415323 8E269352 Hs949 neutrophil cytosolic fxtor 2 (65kD, chr 133 116 060
409119 AA531133 Hs 4253 hypothedcal protein MGC2574 133 152 134
419652 AL157485 Hs 91973 hypothedcal protein 132 207 129
415697 AI365603 Hs 198271 DKFZP566I1024 protein 132 200 133
434359 AF129536 HS 284226 F-box only protein 6 132 207 139
442932 AA457211 HS8858 bromodomain adjxent to zinc finger doma 132 125 191
444029 AW160993 Hs 326292 hypothedcal gene DKFZp434A1114 132 163 1*44
456974 M12529 Hs 169401 apolipoprotein E 132 1 7 085
447733 AF157482 Hs 19400 MAD2 (mitodc aπest deficient, yeast, h 132 251 123
448610 NM_O06157 Hs 21602 nel (chιcken)-lιke 1 131 312 131
426490 NM 001621 Hs 170087 aryl hydrocarbon receptor 131 121 165
427584 BE410293 Hs 179718 v-myb avian myeloblastosis viral oncogen 131 168 1 7 417059 AL037672 Hs 81071 extrxellular matnx protein 1 131 130 214
407777 AA161071 Hs 71465 squalene epoxidase 131 145 143
408536 AW381532 Hs 135188 ESTs 131 138 090
410423 AW402432 Hs 63489 protein tyrosine phosphatase, non-recept 131 181 149
422486 BE514492 Hs 117487 gene πea HD on 4p163 with homology to 131 163 131
409154 U72882 Hs 50842 interferon-induced protein 35 131 169 129
425003 AF119046 Hs 154149 apunmc/apyπmidinic endonudease(APEX 131 174 139
441406 Z45957 Hs 7837 phosphoprotein regulated by mitogenic pa 131 143 094
421975 AW961017 Hs 6459 hypothedcal protein FU 11856 130 253 134
417361 NM 000275 Hs 82027 xulxutaneous albinism II (pink-eye dil 130 138 138
425676 AW410656 Hs 159161 Rho GDP dissociation inhibitor (GOI) alp 130 211 136
427289 AI097346 phosphosenne aminotransferase 130 227 148
427747 AW411425 Hs 180655 seπne/threonine kinase 12 130 168 179
422296 AA360231 Hs 114416 Homo sapiens, Similar to fraπsducm (bet 130 150 130
436481 AA379597 Hs5199 HSPC150 protein similar to ubiquidn-con 130 142 213
423062 NM 003655 Hs 5637 ESTs 130 158 130
439740 AL365512 Hs 6657 hypothedcal protein bK1048E95 130 177 135
409340 BE174629 Hs 321130 hypothedcal protein MGC2771 130 157 151
416920 AA176455 Hs 80475 polymerase (RNA) II (DNA directed) polyp 130 167 144
430451 AA836472 Hs 297939 cathepsin B 130 149 116
457400 AF032906 Hs 252549 cathepsin Z 130 140 121
403506 C3001912gι|6677647lref|NP_0336021| zm 129 188 126
424867 AI024860 Hs 153591 Not56 (D melanogasterHike protein 129 264 131
408815 AW957974 Hs 25485 hypothedcal protein FU22341 129 179 136
416322 BE019494 Hs 79217 pyrrolιπe-5caboxylate reductase 1 129 159 180
440795 AA262133 Hs 99741 ESTs, Weakly similar to PNL1.HUMAN PEANU 129 201 143
421846 AA017707 Hs1432 protein kinase C substrate 80K-H 129 170 134
425966 NM 001761 Hs 1973 cyclm F 129 163 150
446766 AF083208 Hs 16178 apoptosis antagonizing transcnpdon fx 129 171 140
406827 AA971409 gb op92c04 s1 NCI_CGAP_Lu5 Homo sapiens 129 204 135
418613 AA744529 Hs 86575 mitogen-xdvated protein kinase kinase 129 141 194
443086 AW977125 sine oculis homeobox (Drosophila) homolo 129 124 129
439146 AW138909 Hs 156110 immunoglobulin kappa constant 129 199 136
434398 AA121098 Hs3838 serum-mducible kinase (SNK) 129 118 132
418322 AA284166 Hs 84113 cyclin-dependent kinase inhibitor 3 (CDK 129 131 219
400261 Eos Control 129 159 136
413781 J05272 Hs850 IMP (mosine monophosphate) dehydrogenas 129 167 153
412315 AW936678 gb PM2-DT0025080300-004-a04 DT0023 Homo 128 126 107
420372 AW960049 Hs 293660 Homo sapiens, clone IMAGE 3535476, mRNA, 128 185 140
425449 X52056 Hs 157441 spleen fxus forming virus (SFFV) provir 128 145 114
454478 AW805749 superoxide dismutase 2, mitxhondπal 128 229 107
410275 U85658 Hs 61796 transcnpdon fxtor AP-2 gamma (xdvat 128 120 093
406016 Target Exon 128 147 131
449609 BE246434 Hs 289026 guanine nudeodde binding protein (G pr 128 126 302
426059 BE292842 Hs 166120 interferon regulatory fxtor 7 128 176 123
412773 H15785 Hs 74573 similar to vxcima virus Hindlll K4L OR 128 160 130
452700 AI859390 Hs 288940 five-span transmembrane protein M83 128 151 122
408543 N78098 Hs 44289 ESTs 128 202 108
408822 AW500715 Hs 57079 Homo sapiens cDNA FU13267 fis, clone OV 127 128 351
425069 AA687465 Hs 298184 potassium voltage-gated channel, shaker- 127 166 139
444681 AJ243937 Hs 288316 chromosome 6 open reading frame 9 127 147 155
430794 NM 000166 Hs 333303 gap |uncdon protein, beta 2, 26kD (conn 127 181 089
430637 BE160081 Hs 256290 S100 calcium-bmdmg protein A11 (calgiz 127 135 168
440502 AI824113 Hs 78281 regulator of G-protem signalling 12 127 167 131
441598 AI733219 Hs 58262 ESTs 127 130 130
431921 N45466 Hs 58879 ESTs 127 200 116
459345 AW503672 gb UI-HF-BNO-ald-h- 11-O-UI r1 NIH_MGC_50 126 144 133
452436 BE077546 Hs 31447 ESTs, Moderately simila to A46010 X-lin 126 120 145
426334 BE305081 Hs 169358 hypothedcal protein 126 122 189
414044 BE614194 Hs 75721 profilm 1 126 148 151
405268 ENSP00000223174* KIAA0783 PROTEIN 126 119 225
416602 NM 006159 Hs 79389 Protein kinase C-bmding protein NELL2 126 119 403
439529 BE293492 Hs 293984 hypothedcal protein MGC13102 126 183 119
421254 AK001724 Hs 102950 coat protein gamma-cop 126 161 123
417785 X59812 Hs 82568 cytxhrome P450, subfamily XXVIIA (stero 126 184 068
419395 BE268326 Hs 90280 5ammoιmιdazole-4-carboxamιde nbonucle 126 166 134
418968 NM 000078 Hs 89538 cholesteryl ester transfer protein, plas 126 142 119
441553 AA281219 Hs 121296 ESTs 126 129 128
446619 AU076643 Hs313 sxreted phosphoprotein 1 (osteopondn, 125 122 065
424624 AB032947 Hs 151301 Ca2-*dependent xdvator protein for sxr 125 117 295
450087 BE293180 Hs 24379 MUM2 protein 125 178 128
429604 AK001851 Hs 210778 hypothedcal protein FU10989 125 118 125
429380 AF023268 Hs 200600 sxretory earner membrane protein 3 125 222 125
440251 AW796016 Hs 332012 Homo sapiens, clone IMAGE 3687782, mRNA 125 190 139
416759 AK000978 Hs 79741 hypothedcal protein FU10116 124 132 153
435466 BE619165 Hs 29203 G protein beta subumt-like 124 196 132
450621 AW297288 Hs 55918 hypothetical protein FU11354 124 161 127
400214 NM_007002 Homo sapiens cell membrane gly 124 188 132
435013 H91923 Hs 110024 NM_020142 Homo sapiens NADH ubiqumone o 124 176 125
414733 BE514535 Hs 77171 minichromosome maintenance deficient (S 124 182 142
406851 AA609784 maior histocompatibility complex, dass 124 168 119
448498 AA418276 ESTs 124 173 129
440087 W28969 HS7718 hypothedcal protein FU22678 124 170 138 411365 M76477 Hs 289082 GM2 ganglioside xdvator protein 124 161 116
426502 Y07759 Hs 170157 myosin VA (heavy polypepdde 12, myoxm) 124 265 124
452056 AW955065 Hs 101150 Homo sapiens, clone IMAGE 4054156, mRNA, 124 149 150
427390 AI432163 Hs 268231 Homo sapiens cDNA FU23111 fis, clone L 124 117 210
429954 AI918130 Hs 21374 ESTs 123 119 477
421178 BE267994 Hs 102419 zinc finger protein 123 162 128
442609 AL020996 Hs 8518 selenoprotein N 123 230 124
416188 BE157260 Hs 79070 v-myc avian myelocytomatosis viral oncog 123 118 090
410127 AA354313 Hs 58685 CD5 antigen (p5562) 123 168 123
452244 N33530 Hs 176674 ESTs 123 293 123
406718 AA505525 Hs 169476 glyceraldehyde-3-phosphate dehydrogenase 123 156 129
436939 AA853680 HS5345 argmyl aminopepddase (ammopepddase B 123 168 123
414457 AW514320 Hs 76159 ATPase, H transporting, lysosomal (vxuo 123 158 120
416929 N20535 melastadn 1 123 192 120
401106 Target Exon 123 182 129
408981 AW500797 Hs 49427 Gem-interxling protein 123 140 159
413317 U53225 Hs 75283 sorting nexm 1 123 143 144
422481 AL050163 Hs 117339 DNAX-xdvadon protein 10 123 171 124
425455 AL137522 Hs 157777 casein kinase 1, gamma 1 123 195 129
451524 AK001466 Hs 26516 hypothedcal protein FU10604 123 207 127
414399 L47345 Hs 155202 transcnpdon elongadon fxtor B (Sill) 122 187 119
422034 AC006486 Hs 333069 Ets2 repressor fxtor 122 155 121
434224 AA380731 Hs84 interieukin 2 rxeptor, gamma (severe co 122 155 151
429574 BE268321 Hs 208912 hypothedcal protein MGC861 122 149 146
411742 AW247593 Hs 71819 eukaryodc transladon initiation fxtor 122 164 140
449027 AJ271216 Hs 22880 dipepddylpepddase III 122 163 130
418004 U37519 Hs 87539 aldehyde dehydrogenase 3 family, member 122 124 071
451481 AA30O228 Hs 295866 hypothedcal protein DKFZp434N1923 122 220 126
422739 H20106 Hs 119591 adaptor-related protein complex 2, sigma 121 155 121
424326 NM_014479 Hs 145296 ADAM-like dismtegnn protease, dxysin 121 113 329
404186 NM.019602 Homo sapiens butyrophilin-like 121 159 121
447604 AW089933 Hs 301342 hypothedcal protein MGC4342 121 125 200
427979 BE379776 Hs 181309 proteasome (prosome, mxropam) subunit, 121 114 125
414509 AW161311 Hs 76294 CD63 andgen (melanoma 1 andgen) 121 139 125
428468 AA171388 Hs 184482 DKFZP586D0624 protein 121 166 122
419700 AF084935 Hs 92357 galxtokinase 1 121 163 074
430948 AI347578 Hs 124015 hypothedcal protein MGC2605 121 148 121
448143 AF039704 Hs 20478 ceroid lipofuscmosis, neuronal 2, late 120 175 123
448499 BE613280 Hs 77550 hypothedcal protein MGC1780 120 154 129
442173 N76101 Hs8127 K1AA0144 gene product 120 154 131
409632 W74001 Hs 55279 serine (or cysteine) proteinase inhibito 120 118 111
448230 BE395949 Hs 94814 hypothedcal protein MGC2865 120 183 119
403817 NM_015271 Homo sapiens bipartite modf- 120 122 161
411678 AI907114 Hs 71465 squalene epoxidase 120 115 201
452423 AA991724 Hs 180535 hypothedcal protein MGC10966 120 179 120
424046 AF027866 Hs 138202 senne (or cysteine) proteinase inhibito 120 234 120
447233 AW246333 Hs 17901 Homo sapiens, clone IMAGE 3937015, mRNA, 120 193 120
422565 BE259035 Hs 118400 singed (Drosophιla)-lιke (sea urchin fas 120 132 152
446159 NM 013379 Hs 14089 dipepddyl pepddase 7 119 164 122
434563 AW083994 Hs 9469 plxkstnn homology doman-contammg, f 119 153 145
421541 NM 003942 Hs 105584 πbosomal protein S6 kinase, 90kD, polyp 119 175 127
450706 AW167578 Hs 14691 ESTs, Moderately similar to 138022 hypot 119 171 122
430381 NM 006411 Hs 240534 1-xylglycerol-3- phosphate O-xyltransfe 119 166 121
426329 AL389951 Hs 271623 πucleoponn 50kD 119 117 155
421612 AF161254 Hs 106196 8D6 andgen 119 173 130
410182 NM 001983 Hs 59544 excision repair cross-complemendng rode 119 175 118
434171 BE247688 Hs 347349 KIAA0948 protein 118 173 109
424837 BE276113 Hs 333034 N-xetyltransferase, homolog of S cerev 118 213 122
428293 BE250944 Hs 183556 solute earner family 1 (neutral ammo a 118 145 130
453754 AW972580 Hs 172753 ESTs 118 171 135
439012 BE383814 Hs 6455 RuvB (E coli homolog)-lιke 2 118 160 123
422256 M64673 Hs 1499 heat shxk transcnpdon fxtor 1 118 151 128
439863 BE547830 Hs9408 paired immunoglobulm-like receptor beta 118 189 118
430513 AJ012008 Hs 241586 G6C protein 118 207 081
427283 AL119796 Hs 174185 xtoπucleoddepyrophosphatase/phosphodi 118 113 325
441648 H05734 Hs 30559 ESTs 118 156 123
418219 AA731836 Hs 137319 ESTs 118 177 123
406422 Target Exon 118 143 131
414823 AA156531 Hs 103902 ESTs Weakly similar to A44861 keradn, 118 166 123
425720 AA362394 Hs 293984 hypothedcal protein MGC13102 118 158 115
419250 AW770185 U5 snRNP-spxific protein, 116 kD 117 174 121
454390 AB020713 Hs 56966 KIAA0906 protein 117 133 135
428471 X57348 Hs 184510 stratifin 117 119 124
430200 BE613337 Hs 234896 geminm 117 113 196
412965 L06419 Hs 75093 procollagen-lysme, 2-oxoglutarate 5-dιo 117 150 122
430122 NM 013342 Hs 233765 TCF3 (E2A) fusion partner (in childhood 117 169 132
430512 AF182294 Hs 241578 U6 snRNA-assxiated Sm-like protein LSm8 117 112 244
417080 BE392846 Hs 1063 small nuclear nbonucleoprotein polypept 117 193 118
423102 AW067812 Hs 303025 chromosome 11 open reading frame 24 117 189 117
408393 AW015318 Hs 23165 ESTs 116 110 191
424292 AA338432 gb EST43554 Fetal bran I Homo sapiens c 116 161 121
446759 R61463 Hs 16165 expressed in xdvated T/LAK lymphxytes 116 1 5 123
427324 AA159587 Hs 285932 hypothetical protein FU 23322 116 150 123 446055 AI815981 Hs 12909 mucolipiπ 1 116 149 110
414432 BE378174 Hs 26506 Homo sapiens clone CDABP0005 mRNA sequen 116 167 120
417900 BE250127 Hs 82906 CDC20 (cell division cycle 20, S cerevi 116 166 132
411305 BE241596 Hs 69547 myelin basic protem 116 115 429
438930 AW843633 Hs 343261 hypothedcal protein AL110115 116 137 134
407239 AA076350 Hs 67846 leukxyte immunoglobuliπ-like rxeptor 115 182 117
427458 BE208364 Hs 29283 ESTs Weakly simila to LKHU proteoglyca 115 146 132
402160 Target Exon 114 123 112
416881 N32520 Hs 141358 ESTs 114 242 114
420223 N27807 πbosomal protein L4 114 123 114
450778 U81375 Hs 25450 solute earner family 29 (nucleoside tra 114 138 127
429538 BE182592 Hs 139322 small proline-πch protein 2A 114 116 352
428342 AI739168 Homo sapiens cDNA FLJ 13458 fis, done PL 113 113 113
436696 AA725678 Hs 120487 ESTs 113 122 113
448950 AF288687 Hs 9275 CGI- 152 protein 112 152 119
437696 Z83844 Hs5790 hypothedcal protein dJ37E165 112 131 108
425009 X58288 Hs 154151 protein tyrosine phosphatase, rxeptor t 112 108 120
412099 U64198 Hs 73165 interieukin 12 receptor, beta 2 112 293 112
407951 W77762 Hs 79015 antigen identified by monoclonal andbod 112 111 343
408116 AA251393 Hs 289052 Homo sapiens, Similar to RIKEN cDNA 5430 112 150 112
450296 AL041949 Hs 24756 hepatocyte growth fxtor-regulafed tyros 111 148 112
420697 AA827705 Hs 26605 ESTs 111 219 111
438915 AA280174 Hs 285681 Williams-Beuren syndrome chromosome regi 111 273 111
418399 AF131781 Hs 84753 hypothedcal protein FU12442 110 143 114
450358 AB010098 Hs 24907 coronin, xbn-binding protein, 28 110 135 119
444783 AK001468 Hs 62180 anillm (Drosophila Scraps homolog), xt 110 143 110
408801 AI866590 Hs 63405 Homo sapiens, clone IMAGE 3609337, mRNA, 110 153 114
402622 C1003392* gι|12314272|emb|CAC005911| (A 110 159 106
418661 NM 001949 Hs1189 E2F transcnpdon fxtor 3 109 182 109
442680 BE270707 Hs 8583 similar to APOBEC1 109 149 124
439702 AW085525 Hs 55964 ESTs 109 168 109
423858 AL137326 Hs 133483 Homo sapiens mRNA, cDNA DKFZp434B0650 (f 109 110 173
443759 BE390832 Hs 134729 FXYD doman-contaning ion transport reg 109 123 125
414396 BE548266 Hs 76057 g3lxtose-4-epιmerase, UDP- 109 107 123
401558 ENSP00000220478* SECRETOGRANIN III 108 154 108
428411 AW291464 Hs 10338 ESTs 108 107 619
422051 AW327546 Hs 111024 solute earner family 25 (mitxhondπal 108 125 093
414694 NM 015362 Hs 76907 HSPC002 protein 108 118 112
453883 AI638516 Hs 347524 cofxtor required for Sp1 transcπpdona 107 115 131
420856 BE513294 Hs 205736 HLA class II region expressed gene KE2 106 147 108
412265 AA101325 Hs 86154 hypothetical protein FU12457 106 117 122
429259 AA420450 Hs 292911 Plakophilm 106 108 073
417381 AF164142 Hs 82042 solute earner family 23 (nucleobase tra 105 104 084
415825 Y18024 Hs 78877 inositol 1,4,5tπsphosphate 3-kιnase B 105 109 137
444438 N32755 Hs 322489 ESTs 104 113 105
407394 AF005081 gb Homo sapiens sk -spxific protein (x 104 122 078
404960 eyes absent (Drosophila) homolog 3 104 106 104
408972 AL050100 Hs 49378 DKFZP586D0919 protein 104 109 113
414477 U41635 Hs 76228 amplified in osteosar∞ma 103 111 103
409327 L41162 Hs 53563 collagen, type IX, alpha 3 103 102 233
435056 AW023337 Hs5422 glycoprotein M6B 103 102 356
415314 N88802 Hs 5422 glycoprotein M6B 102 102 402
408591 AF015224 Hs 46452 mammaglobm 1 100 141 005
401203 Target Exon 100 102 098
400304 AF005082 Hs 113261 Homo sapiens skin-specific protein (xp33 100 149 056
407395 AF005082 gb Homo sapiens skm-spxific protein (x 100 169 091
411388 X72925 Hs 69752 desmocoltin 1 100 312 100
428618 AA885360 Target CAT 100 177 100
402860 ENSPOO0O0239210 DJ50O244 (novel protein 100 153 100
437211 AA382207 Hs 5509 ecotropic viral integradon site 2B 100 139 100
409269 AA576953 Hs 22972 steroid 5 alpha-reductase 2-lιke, H5AR g 100 146 100
409190 AU076536 Hs 50984 sarcoma amplified sequence 100 080 100
416143 AI955650 glutam yl-pepdde cyclotraπsferase (glu 100 196 ιoo
401588 C15000180* gι|544344|sp|O05859|FOR4 MOUS 100 204 100
419519 AI198719 Hs 176376 ESTs 100 191 100
448816 AB033052 Hs 22151 KIAA1226 protein 100 182 100
440270 NM 015986 HS7120 cytokine receptor-like molxule 9 100 115 100
418618 U66097 Hs 86724 GT cyclobydrolase 1 (dopa-responsive dy 100 166 074
422836 AL037365 Hs 194093 AKAP-binding sperm protein roppoπn 100 221 100
452461 N78223 Hs 108106 transcnpdon fxtor 100 161 100
428479 Y00272 Hs 334562 cell division cycle 2, G1 to S and G2 to 100 142 100
422420 U03398 Hs 1524 tumor nxrosis fxtor (ligand) superfami 100 181 100
429477 AI275514 Hs6658 ESTs 100 167 100
454027 R40192 Hs 21527 Human DNA sequence from clone GS1-115M3 100 105 100
416209 AA236776 Hs 79078 MAD2 (mitodc arrest deficient, yeast, h 100 179 100
451993 AA765776 Hs 122983 ESTs 100 215 100
416947 N23282 Hs 184341 ESTs, Weakly similar to B34087 hypothed 100 167 100
441606 R37263 Hs 21065 ESTs, Moderately similar to PC4259 fem 100 187 100
442590 AI002686 Hs 130313 ESTs 100 259 100
404831 C1002937* gι|7499208|pιr||T20993 hypothe 100 144 100
428454 U55936 Hs 184376 synaptosomal-assxiated protein, 23kD 100 1 7 100
419717 H07970 Hs 92458 G protein-coupled rxeptor 19 100 178 100
408611 NM.004367 Hs 46468 chemokine (C-C modf) rxeptor 6 100 164 100 421666 AL035250 Hs 1408 endothelin 3 1 00 063 1 00
446155 AI553695 Hs 159422 Homo sapiens cDNA FU 13997 fis, done Y7 1 00 1 60 100
423899 NM 001427 Hs 134989 engrailed homolog 2 1 00 291 1 00
423130 AW897586 Hs 21213 ESTs 1 00 1 65 1 00
433843 AW021423 Hs 112819 ESTs 1 00 208 1 00
458574 AW384436 Hs 135265 Homo sapiens done FLB8436 PR02277 mRNA, 1 00 1 00 1 00
430205 AB025904 Hs 235168 carbonic anhydrase XIV 1 00 1 41 1 00
427335 AA448542 Hs 251677 G andgen 7B 1 00 1 15 1 00
439951 AI347067 Hs 124636 ESTs 1 00 1 80 1 00
420248 AI377191 Hs 44714 ESTs 1 00 215 1 00
446259 AA425204 Hs 334721 hypothedcal protein FU13391 1 00 235 1 00
447164 AF026941 Hs 17518 vipinn, similar to inflammatory respon 100 1 53 1 00
447289 AW247017 Hs 36978 melanoma andgen, family A, 3 1 00 1 73 1 00
408758 NM 003686 Hs 47504 exonuclease 1 1 00 1 59 1 00
453745 AA952989 Hs 63908 hypothedcal protein MGC14726 1 00 1 73 1 00
436609 AI022514 Hs 131380 ESTs 1 00 1 96 1 00
419308 N40321 gb yx80g07 r1 Soares melanxyte 2NbHM Ho 1 00 228 1 00
421650 AA781795 Hs 122587 ESTs 1 00 1 74 1 00
459578 AW612538 Hs 304491 EST 1 00 216 1 00
446152 AI292036 ESTs 1 00 1 66 1 00
449579 AW207260 Hs 134014 ESTs, Weakly simila to T46425 hypotheti 1 00 204 1 00
418673 NM 005582 Hs 87205 lymphxyte andgen 64 (mouse) homolog ( 100 1 75 100
415004 AA158925 Hs 240849 ESTs. Weakly similar to GBP1.HUMAN INTER 1 00 1 85 1 00
426274 D38122 Hs 2007 tumor nxrosis fxtor (ligand) superfami 1 00 1 92 1 00
453922 AF053306 Hs 36708 budding uninhibited by benzimidazoles 1 1 00 1 72 1 00
417791 AW965339 Hs 44269 ESTs 1 00 1 52 1 00
424905 NM 002497 Hs 153704 NIMA (never in mitosis gene a)-related k 100 202 1 00
416445 AL043004 Hs 79337 KIAA0135 protein 1 00 1 28 1 00
408375 AI224520 Hs 40930 ESTs 1 00 1 92 1 00
406964 M21305 FGENES predicted novel sxreted protein 1 00 046 1 00
408522 AI541214 Hs 46320 Small proline nch protein SPRK [human, 1 00 1 00 248
412828 AL133396 Hs 74621 pπoπ protein (p27-30) (Creutzfeld -Jakob 098 098 324
422270 AF114494 Hs 114062 protein tyrosine phosphatase-like (prod 095 0 % 306
446488 AB037782 Hs 15119 KIAA1361 protein 094 096 1 61
433435 BE545277 Hs 340959 Ts transladon elongadon fxtor, mitxh 094 094 076
409402 AF208234 Hs 695 cystadn B (stefin B) 093 091 1 55
423942 AF209704 Hs 169407 glycolipid transfer protein 092 093 209
414219 W20010 Hs 75823 ALL1-fused gene from chromosome 1q 091 091 408
429211 AF052693 Hs 198249 gap juncdon protein, beta 5 (∞nnexin 3 090 081 073
417632 R20855 Hs 5422 glycoprotein M6B 090 092 389
449092 U91641 alpha2.8-sιalyltransferase 089 079 084
426716 NM 006379 Hs 171921 sema domain, immunoglobulin domain (Ig), 089 092 370
445033 AV652402 Hs 72901 cyclin-dependent kinase inhibitor 2B (p1 088 090 202
408349 BE546947 Hs 44276 homeo box C10 088 087 073
429345 R11141 Hs 199695 hypothedcal protein 085 084 069
451621 AI879148 Hs 26770 fatty xid binding protein 7, brain 084 085 1 32
417022 NM.014737 Hs 80905 Ras assxiadon (RalGDS/AF-6) domain (am 084 088 337
405885 Target Exon 081 0 71 1 00
407788 BE514982 Hs 38991 S100 calcium-binding protein A2 078 078 090
417515 L24203 Hs 82237 ataxia-telangixtasia group D-assxiated 0 77 073 071
421100 AW351839 Hs 124660 Homo sapiens cDNA FU21763 fis, clone C 075 078 469
440274 R24595 Hs 7122 scrapie responsive protein 1 074 078 542
425071 NM 013989 Hs 154424 deiodmase lodothyronine, type II 070 075 429
412719 AW016610 Hs 816 ESTs 070 077 399
432467 T03667 Hs 239388 Human DNA sequence from clone RP1-304B14 069 073 379
437191 NM 006846 Hs 331555 senne protease inhibitor, Kazal type, 5 065 064 1 11
452487 AW207659 Hs 6630 Homo sapiens cDNA FU13329 fis, clone OV 061 065 320
448133 AA723157 Hs 73769 folate receptor 1 (adult) 061 022 049
439659 AW970780 Hs 59483 Homo sapiens cONA FU14471 fis, clone MA 049 030 067
419092 J05581 Hs 89603 mucin 1, transmembrane 041 011 034
417079 U65590 Hs 81134 interieukin 1 rxeptor antagonist 023 030 035
TABLE 49B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Axession Genbank axession numbers
Pkey CAT Number Accession
430540 713.2 BC017171 BC012195 NM.007126 AF10O752 AL137377 Z70768 BM
BM045810 AU120387 BG770238 BG686740 BG913323 BI759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847 AI770171 BF196861 BE856897 AA463876 AI375927 AA648810 AA948193 AA490916 AI459893 AI458188 AI240408 AI191843 AI131029 AW768399 AI365196 AW337984 AW026150 BE466591 BE674599 AI818438 AA772197 AI651927 AW151143 BI198825 BG819083 BM458764 BE903567 BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542 AW246215 BE501897 BE903610 BE561530 BE560537 BE903782 BE732947 BI227204 BG761305 BE262642 BE391848 BE382475 BG008258 BI547991 BI4590998E391391 BE259420 BE298109 AW245422 AI423847 AI914618 H80534 BE301004 AL531791 AI435581 BF793112 AL577303 AA373265 BE746965 BF743630 BE879296 AI359493 BM018598 AI689260 AW072450 F20201 AW151405 AW517572 AA773468 BG259694 BE391163 BG621529 AI421728 BG767231 BM462953 BG340524 W52648 AA113434 BE785431 BI041981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 BI091658 N72512 W58732 W85690 BG958989 AI205206 H19721 W17051 W77958 BI262010 AA844319 W74143 W72214 N85194 BE734033 BG164099 AA931069 F13645 R41394 AK025758 BG180977 BE349455 AA812018 AA740241 AI027722 AH 50356 AA886395 AW9776278E220225 AA884082 AW518114 AI243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 AI251109 R07704 AA765606 AA724593 AI918399 AI537550 AA491103 AW008188 R07703 AA989120 AA746235 AW028983 AA789102 AU185751 AW971465 AA489681 AW971893 AW612086 BE077936 BI860809 BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591
431317 997174.1 AW970601 AW613399 AA503435 AA502682 N91138 453912 32562.3 BM472224 BI966849 BI966735 AW973032 BI962894 BI963048 AA548765 AI926504 AA041551 AW043754 AI0867O2 AW0081O5 AA974849 AW614893
AA553737 AA916996 AW262982 AI580991 BF726843 AV693312 W35325 AA039927 BG460936 AW388482 AW388420 BF374777 W01360 N94710 H87967 420218 191547.1 AW958037 R42557 AI337047 AA948360 AI638005 AA459950 AI624915 AI638047 AI467856 AI521826 AA860305 AI932315 AW003092 AW271756 AW779380 AA609879 AI634791 AI493770 AI565211 Z41145 AI627952 AA303734 BE349457 AW196765 AA256527 BE089727
458997 11847 4 BM453041 AA760783 BE218582AI340046AW166131 BF515854 AI630296 AA461307 AI090881 AW023059AA155797AA115486AL597396
AW889004 AW937420 AA137082 AA013374 BG619478 BG401839 430015 713 2 BC017171 BC012195 NM 007126 AF100752 AL137377 Z70768 BM474865 BG754806 AU124376 BG757203 BG764420 BG775028 BG824418
BM045810 AU120387 BG770238 BG686740 BG913323 BI759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847 AI770171 BF196861 BE856897 AA463876 AI375927 AA648810 AA948193 AA490916 AI459893 AI458188 AI240408 AI191843 AI131029 AW768399
AI365196 AW337984 AW026150 BE466591 BE674599 AI818438 AA772197 AI651927 AW151143 BI198825 BG819083 BM458764 BE903567 BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542 AW246215 BE501897 BE903610 BE561530 BE560537 BE903782 BE732947 BI227204 BG761305 BE262642 BE391848 BE382475 BG008258 BI547991 BI459099 BE391391 BE259420 BE298109AW245422 AI423847 AI914618 H80534 BE301004 AL531791 AI435581 BF793112 AL577303 AA373265 BE746965 BF743630 BE879296 AI359493 BM018598AI689260AW072450 F20201 AW151405AW517572AA773468 BG259694 BE391163 BG621529AI421728 BG767231 BM462953
BG340524 W52648 AA113434 BE785431 BI041981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 BI091658 N72512 W58732 W85690 BG958989 Al 205206 H19721 W17051 W77958 BI262010 AA844319 W74143 W72214 N85194 BE734033 BG164099 AA931069 F13645 R41394 AK025758 BG180977 BE349455 AA812018 AA740241 AI027722 AI150356 AA886395 AW977627 BE220225 AA884082 AW518114 AI243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 AI251109 R07704 AA765606 AA724593 AI918399 AI537550 AA491103 AW008188 R07703AA989120AA746235AW028983AA789102AU185751 AW971465AA489681 AW971893AW612086 BE0779368I860809
BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591 425231 235504.1 AA527161 BG211784AA527065AA505489AW512550
417282 2142 2 AK025474 U11293 AF141304 BM424202 AL539879 AL554793 AL543707 AL549509 BI753328 BG755797 BI856494 BE901116 AL556989 AU133347
BI838505 AW949559 BM012604 BG773980 BG661309 BI260149 BF436764 BG983060 BF822225 BI0597288F917866 BF917609 BF914374 D31003 AA234218 AJ420466 BM083921 BE856788 BE669957 BF430992 AW614978 AW205958 BF110763 BF222758 AA195232 AI341353 AI698676
AI093230 AI123522 AI656594 AI208758 AA975916 AI089224 AI264922 AA256604 AA659637 BE218707 AA195203 AW999239 AW139706 N31717 AW205941 R95955 N39147 BM015411 AL576975 BF689524AL563130 BI858155AA417889AL513995 AL568815AU160693AA836028 H84388 AL517078 AL546480 AL530507 AL561042 AA024435 W47314 AI680513 AA456116 BF836679 AW975173 H24039 AW105059 BE548113 AW370257 BM011139 AW675130 BE276045 BF933396 AL517903 AA886367 BI030596 BG477193 BF973867 406687 0.0 M31126
452194 90339.1 AI694413 AW994700 AI912946 N73548 AI082035 AW271652 W24189 W24182 AI719718 AA024658 AW810120 AW015394 T79755 AA988043
AI709339 442643 2736.1 BC001588 BC007424 AF016369 NM.004697 BI756186 BE257019 BG500792 BI862776 AL121371 BG574833 AA703250 AA179511 AW052006
AI280150 AI914000 AI358319 AI081204 AI082594 AA992449 AI470821 AI655744 AW237529 AA678858 AI984430 BF433055 BE467594 BE467573 AA035630 AI289987 AI184802 AI681391 AW592416 AI138377 AI139266 AA961714 AI800163 AA418751 AW451928 AA668676 AI273444 AI494387
BE046912 AI276555 BF196021 AA700055 AA609305 AA772596 AI635758 AI635749 H95459 AW610290 BE464994 AA527136 BF374802 AI800175 AW195227 AI189676 BF802049 AL513632 AL554911 AL538845 BE297273 AA315321 BM451920 BE269268 BE292835 BE018128 BG755713 BM041095 BG677009 AL039691 BF995709 BE735586 BE296453 BG393609 BG824453 AL567522 AI745257 AW388641 AW301265 AI141144 AW029280 AU149362 AU152328 AA418960 AL121009 AI890398 AL528748 H13050 T47086 BI000575 BF334914 BF109661 R44450 H13259 T47087 AW388646 BF305834 AL577515 BM041600 BE889299 BF239768
448243 13061_2 BG166513 AA479726 BE622314 AL134913 BE006305 BE006312 BE006298 AA044582 AW994956 AA234175 AA043906 BE006303 BF327669
BE006317 BF326759 BF541959 430441 1438_6 BG108218 BE560548 AW380115 BE269629 AI911518 AW380113 AA902964 AA455001 AI276529 AI685597 AA970496 D61084 AW380068 AW380080
R00283 C15236 AW327776 D80759 432810 101919_1 BG292389 C06094 AI668930 AW104534 AA310513 AA830127 AW134897 AA046953 AW965490 AI810530 BF092924 AA334151 AA334725 D31302
R20723 AA263003 BI824635 AI276287 AI684428 AI524234 AI335035 AW014704 AI911443 AA972102 AI367512 AI126670 AW016017 AI286003 AI147163 AA626033 AI539156 AA565542 AI094253 AW512612 BE889628 AA744752 BE646306 AW471324 AA999975 AA863400 H17550 AI991439 R46187 BE929954 AA333976 D63102 BF744491 446019 658727.1 AI362520 D25917AI670784AI742347AW269789AI270700AW610541 AW793036AW793035AW610540AW362220AW362166AW362214 AW362225AW362228AL119827
453331 16559.1 BG571303 AA410586 AA035018 BG572117 BG620022AA 147247 BG005785BG014448 R31981 H02668 H12498 R36203 BF992089 R73999T49904
R75732 BI057974 T53681 AA147933 N50695 R68588 R25671 R31935 R25110 R36105 AK055628 BE157467 AW663674 AA190993 H01642 BF510304 AA626915 AA746952 AH 61014 AA099554 BG572534 AI803329 AI809932 AI808765 AA411449 AI378760 AA976929 AI378620 AA909684 R75632 AI360919 AI350463 AW069127 AA411621 AA742532 H12451 BE208298 H03612 H12839 N58781 R75957 BF996484 Al 240665 BF989591 BI056086 BG001590 BF107035
429978 35194.2 BE738425 BE738323 BM126944 AW629678 AW265195 AI916735 AI394255 AI573090 AI354442 AW612857 AI339558 AI919424 AI377532 AI354441
AI308821 AA772275 AW055215 AI589705 AI336532 AA806547 AV682125 H93575 AW071172 AW769904 AI863985 AW265018 AW196655 D79662 BE042393 N75017 AW014741 C75509 BE748621 H92431 AW079261 AW901780AA329482AW960115BI260621 AI767525 R3166381918664 AW963196 C06195 A1678018 452203 2630.1 BC014081 NM_000593 X57522 L21208 L21207 L21206 L21205 L21204 AL561404 AL546423 AL560492 AL556882 AL541576 AL550654 BI823519
BI770023 AL554969 BI489906 AI304693 AW295947 BM146642 X57521 BG820143 BE898390 F06770 F12630 BM423610 AL561518 BM009470 BG742981 AA279685 AA847441 AA313737 BF172639 BF897216 BF914190 BF903647 S70277 AI569694 AW073296 AI361433 AA564644 AA487429 BE858232 AA838610 AI539114 AI719375 AI829129 BG057675 AI423422 AU158860 BE300655 AW170777 AA586956 AL571889 AL556850 AL576404 AL582800 BI256544 BF342301 BG875994 AA054458 AA353161 AI940434 BE816522 AL577636 AI479650 AW150377 AU154395 AW951271 AI032220 AI819778 AI346733 AW771150 AW512525 AI249904 AA279809 AI352549 AW512517 BG056280 AA521222 BE271141 AL581932 AL541575 BI819184
AV660190 AL556475 AI620020 AW089888 AW079179 Z21518 AA687601 F04651 AI783961 T57198 AI433367 T78652 AL554968 AA365648 AL582619 BE874601 BF804669 AL574458 BM145502 AI266514 AI538823 AI475626 AA948210 AA884054 AA487637 AA031844 AA535221 AW794256 AW361447 BE788505 AI682892 AA830989 AA862356 AA653084 BM009154 AA135727 H05927 H23433 R42244 N79997 AW366665 AW366601 AA678742 AL556474 AA135770 BE774050 BF914200 H88457 AA627746 BI560216 BI753586 458098 23945.1 AI082245 BE467534 AI797130 BE467063 BE467767 BE218421 AI694996 BE327781 BE327407 BE833829AA989054AA459718BE833855 BE550224
AA832519 AF086393 AV733386 BE465409 N29245 W07677 AA482971 BE503548 H18151 AA461301 W79223 W74510 AI090689 AL600773 AL600781 N46003 R28075 R34182 BE071550 AW885857 AI276145 AI276696 H97808 N20540 AI468553 424399 2196_1 NM.058173 AF414087 W72837 BF742809 AW070916 BE092421 AI905687 AA340069 BE074512 AI905623 AI905633 BG202312 W72838 AI139456
BG218084 BE926938 BE186013 AW176044 AW291950 BG185269 BG197186 BG192597 BG183176 BG207535 AI127172 BE815819 AI905624 R75793 BG202313 AI905837 BE815853
427239 20459.2 AL532360 BE794750 AA582906 AI015067 AW271034 BG271636 AW075177 AW071374 AI345565 AI307208 BE138953 BE049086 AI334881
AW075006 AW075181 AA464019 AW302733 AW075100 AW073433 AI802854 AI334909 AI802853 AI345036 AI348921 AI340734 AI307478 AI251289 AW302327 AW072520 AI312145 AW073656 AW072513 AW071289 AI307559 AA876186 T29587 AI307493 AI255068 AI252868 AI252839 AW074809 AI252926 AI252160 AI251662 AI251262 AI610913 AI270787 AI270156 AI252075 AW073469 AW072901 AW072496 AW071420 AI305762 AI254764 AI802837 AI251264 AW073049 AW071311 AI340643 BE138965 BE138502 AW073456 AI334733 AI054335 BE139260 AI054302 AI054060 AI054057
AI053722 AI289711 BE139228 AW470478 AW271039 AW302085 BE041872 AI254494 AI271496 AI252427 BF718773 BF718645 AW074866 BE857822 400222 9287.3 NM.002082 L16862 BG828886 BE795217 BE904064 BE294526 BE297283 BE394617 BE935127 BE935106 F12351 BG823182 H16710
410600 497855.1 BF347859 AW499616 AA191322 AW499617 AL601010 AW575742 AA729043 BE463447 AA086179 BE549623 AI335824 AW408712 BM149172 417324 292720.1 BG775668 BG680336 AW991605 AA455904 AW265494 AW265432 BF911380 AA456370 BF911379 AA195677 BF914311 BF913866 BG775059 BG951874 AI572169
453613 10943.2 BG121705 BF514513 BE812196 AW173164 AI911266 AI161253 AA906295 AA724987 AA972070 AW085313 BI062611 BG119864 W02997 H80902
T91294 H09335 H09332 Z40007 F10399 F02595 F03100 H38987 AI801190 H80903 AW130044 F10391 T80640 H24461 R46234 R51914
411825 7891.1 AK000695 AK000489 BC001688 BG235988 AW006329 AI887644 AI207230 AI148213 AI304333 AI634653 AW662636 AI281247 AA946921 AA424487
BE272330 AI830588 AA159183 AA977141 BG231801 AA631793 AA975194 BF817537 AA477798 BI906631 AW083424 AA625199 NM 017767 AK000334 BF984048 AW815534 AL573992 AA430612 AA928390 AA464447 AW340827 AA424290 AI927759 BG951502 AW881353 BI765535
400270 32329.1 AF067853 NM 000026 X65867 BC018881 S60710 BG686218 BG70789 BI767531 BE74216 BG747544 BG768400 BG323811 AU119991 BG763638
BG393097 BG761706 BI766890 BI457560 BG122629 BF972974 BI194649 BE909022 BG488681 AW328441 AW248366 BG718034 BI598504 BE264146 AW248440 BE410942 BE256756 AI480227 AI758918 BE251966 AI684330 AW518872 AW264087 AA631137 AI742831 AI990690 AI192994 AA417231 AA455931 AA416541 AI652537 AI803674 AA631209 AI923786 AW205704 AI354260 AI198865 BF593386 AW821194 AI693442 AW797594 BE893700 BF242879 BE251315 AA534659 AA494551 BI047923 BG949898 BF246869 BI085069 BM007035 AA665981 AI375483 BG221393 AI867580 AA128025 AW612345 R12769 W92325 R40084 AA191625 D51044 AA599257 BE878335 AA121664 AI146666 BI026299 AI872956 AA788642 AA128068 BF819623 AI277591 AI435105 AI354905 AV747031
442591 58995 1 BC021240 BF430978 BG056212 AW874052 BI856040 AI572156 AI914600 AI002736 BM023413 H91902 AL563177 AL529967 BM023140 BE391587
BG761312 BE277571 BI195388 BE389566 H91851 BE391930 BE391441
410103 366775.1 BG003993 AW589921 AW892489 AW903666
437179 12239.1 AK055109 BC019085 AA187684 BG656226 BM023227 AI932311 AW264381 AA398371 BM021483 AI432433 AI375777 AI129580 AW262782
AA134107 BM023515 AA977504 AI859222 AI348454 R69725 AA975268 BM021207 AL080074AA129218 AW207842 N90581 AA771919 AI092259 AI028416 AI074114 BG656536 BE501677 AW193419 AA917040 W90430 AI342984 AI378957 AL036486 AW020068 BI491093 BF476021 R41226 R69631 F04125 C02343 AA115589 R56480 AI400988 R54266 R31422
451050 11847.4 BM453041 AA760783BE218582 AI340046AW166131 BF515854 AI630296 AA461307 AI090881 AW023059 AA155797 AA115486AL597396
AW889004 AW937420 AA137082 AA013374 BG619478 BG401839
438129 497522.1 BE904404 AA778647 BF431869 AW070999 BG170122 BG191943 BG999184 R42302
439246 388.5 AK054564 AF086057 AI869310 BG393141 BE220500 AI479459 AI866575 AI361301 AI674602 BF001506 AW004996AI446292 AI890883 AI608681
AW131794 AI356096 AI433040 BG057018 AI696166 AW081428 AI392809 AA985226 AW190187 BE896007 BG171443 AW516382 AA731186 N50847 AA417728 F27148 AI003145 AL520675 AL577680 AL578955 AA316669 BF804796 AA768324 AI285396 BG745142 BG325246 BG475289 AL580501 AA832445 AA832168 BF063242 AW251083 BF345614 BE871009 BG698638 BG978245 BG978247
427289 1820.2 BC007350 BG766159 BG769338 BG761999 BG744385 BG770572 AW370610 AW370581 AA978353 AW327973 AW402425 AI889380 AA868504
AW612968 AA630644 AI751211 N26980 AI394506 AA747849 BF154926 BF477185 AA649647 R39135 AI750216 T35363 W36278 AW079375 AW612240 AA505495 AA515380 BG760793 AW370651 BG766029 AW370595 BF229885 BG762422 BG764907 T50662 AA025671 AW815715 AV703420 H65047 AA485582 R56186 H90385 R55913 BI261497 BI018403 BF376945 T75578 BF933325 BF932853 BG502266 AW868934 AV683504 BI018121 N41953 BF933343 BF932871 H08334 R14012 BF897622 T50816 BG698803 BF340083 Z20199
406827 0 0 AA971409
443086 25669.4 BE896316 BG819393 AA187888 AW753122
400261 23110 BC006097 X03066 NM_002120 M26040 AW469119 AW469127 AI299772 AW518149 AI144456 AW628070 AI629032 AI358810 AI880433 AI440472
AI357070 AI865365 AW014799 AI767973 AW518041 AA909398 AW768606
412315 1163860 1 AW936678 AW936821 AW936683 AW936822 AW936781 AW936817 AW936811 AW936653 AW936823 AW936685 AW936815 AW936637 AW936812 AW936730 AW936762 AW936682 AW936732
454478 4273.16 AW796921 AW798102 AW805749 AW805872 BF985060 AW794380 BF380449 AW794466 AW794538
459345 919706.1 AW853325 AW503672
400214 9255.1 AI659839 BE897640 BE907077 BC003059 BC0172458C010733 BM423383 AL537826 AL580324 BG749884 BE910412 BI085225 BG830374
BG765711 BE513420 BE513706 AW249005 BE378229 BE250756 BG389441 BF998736 H61321 BF869238 BG979991 H49658 AA353290 D64154
BM468130 AL549088 BI765497 AL556922 BI833272 BM009270 BI546248 BG750170 BG480128 AL561553 BI559389 BG762029 BG741197 BI561200
BI259044 AL523216 BG333073 BI838073 BE790691 AV762878 BF972560 BI260209 BI333058 BI090606 BG468883 BI598273 BI826098 BE622086
BI758061 BG751116 BE905428 BG764482 AL522174 BG761428 BI836634 BG749048 BG774512 BE280653 BG480630 BG716728 BI766635
BG573991 BG389305 BF971754 BG680599 BE795075 BG324709 AA984290 BE304564 BG283813 BE252914 BF872431 BE407696 BE264894
AL552517 BF872428 BF724779 BE279635 BF804329 BE764960 BF811388 D31335 AW951318 BF992435 BF811453 NM.007002 AL518634
AL574934 AL523534 AL520445 AL521785 AL547001 AL556522 BI829145 BI862487 B1753281 BE258642 AL039594 BG015181 BE925165 BF872433
AI904540 AI904495 AA776741 AA317533 BG476628 R13328 BG489456 BF102495 BF693420 AL526597 BG104181 BG740214 BE393189 AI986312
H61596 AW051180 BI668762 AW938619 BI086232 AA053472 BE264345
406851 0.0 AA609784 R97304 448498 20078.4 BG167206 AA677283 AA677217 AI703389 AI051577 AI912137 H39571 AA650047 AI399798 H24807 AA341614 BG945259 AI074162 AW960920
AA628934 AA659498 AA699617 H14450 H21758 H39576 AA095608 AI049973 BG054505 BG319545 AI742408 AA421324 AI580138 AI375883
AI374848 AI367657 AI374762 AI304678 AA007357 BF477168 AI373751 AA779885 AI801494 BE349021 AI220937 AW338397 AA253409 AA418327
AA872682 AI572030 AI521517 AI572944 AI418670 AI266089 W72413 W76492 AI809207 AI915747 H22230 H21951 H08513 H25154
416929 14596.3 BC017849 BC005892 N42983 BF691239 N42991 N29240 N40292 N33322 N33330 N20535 419250 249447.1 BG755078 BI226909 N41827 AW404060 BI058921 H11253 AA461274 R05714 H00515 BI086965 AI032786 BI089613 BM171783 AI127382 AI660953
AW296271 AI582209 AA460965 AI376115 AI016900 BG055846 AI023644 AA767046 AA815039 AW403510 AI868663 AA815462 AA235654 AW292253
AW959582 AV725205 AW959578 AA300091 W24933 R05715AW770185 H00465 N93714 H11254 T49555
424292 892193.1 AW966308 AA339512 AA338432 420223 191648.1 N27807AA256634 BE276324 428342 6712.1 AK056315 AI015524 AA724079 BI713619 AI377728 AW293682 AI928140 AI092404 AI085630 AA731340 BM469629 AW968804 AA425658 AA769094
BF446026 AW118719 AI332765 AW500888 AW576556 AI859571 AW499664 AW614573 AW629495 AW505314 W74704 AI356361 AI923640
AW070509 AI521500 AL042095 AA60-309 AA761319 AI381489 H45700 AA761333 AW265424 AA909524 AA635311 AA649040 AI392620 Z40708
AI985564 AW263513 AA913892 AI693486 AW263502 AI806164 AW291137 BI061872 BI059498 AA134476 AW084888 AA036967 AW370823 T55263
BI002756 AA489664 BF827261 74741 BF963166
407394 27110.2 AF005081 BG193848 428618 2668.1 BC017998 BI826643 BG715794 BG722697 BI460787 BG773459 H52859 AI652853 AI990773 AW665193 AW340601 AA913806 AI337099 BE045942
AW572790 AW515652 H15004 AA909115 BI465310 BI462024 BI561578 BI463075 BG722527 R86003 BG623286 H15003 BI562131 BG435272
416143 40539.2 BG218868 AV705271 N34158 AL538368 BG186620 BG188697 BG181900 AI200440 BG033721 BF968528 BF792647 AW204668 AA922311 F02735
AW342041 BG217293 BE619664 BE465887 AA745605 AI278924 AI278546 AI280994 AA809678 AA282134 T08599 AA732436 T05478 F04402 AA262267 AI969523 N25559 AI760218 BG217318 BF893160
419308 249928.1 N40321 AA236322 AA236215
446152 2857941.1 AI292036 AI858546 AI277390
449092 4406.1 AK056270 AV706896 AI692935 AI681140 AW162481 AW087114AW157019AI689795 AW251085AW206911 BF438207 AW134945 BE041668
BF111425 U91641 NM.013305 BF968902 U55966 AU130750 BE174853 AI929731 AW161524 R43753 BE779688
TABLE 49C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column ae Genbank Idendfier (Gl) numbers "Dunham, et al " refers to Ihe publicadon entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposidon Indicates nudxtide posidons of predicted exons
Pkey Ref Strand NLposidon
402075 8117407 Plus 121907-122035 122804-122921,124019-12416
405451 7622517 Minus 145949-146227
401747 9789672 Minus 118595118816,119119-119244,119609-11976
401454 9186923 Minus 114659-114832
405545 1054740 Plus 118677-118807,119091-119296,12162512182
401780 7249190 Minus 28397-28617,28920-29045,2913529296,2941
403328 8469086 Minus 120425120703
405547 1054740 Plus 124361-124520,124914-125050
403532 8076842 Minus 81750-81901
400750 8119067 Plus 198991-199168,199315199548
405506 6466489 Plus 80014-80401,80593-81125
400533 6981826 Minus 277132-277595
405779 7280331 Minus 3304533856
402994 2996643 Minus 4727-4969
401781 7249190 Minus 8321583435,83531-83656,83740-83901,8423
401994 4153858 Minus 42904-43124,43211-43336,44607-44763,4519
403969 8569909 Plus 31237-31375,3240532506
401760 9929699 Plus 8312583250,85320-85540,94719-95287
401797 6730720 Plus 6973-7118
401151 9438288 Plus 30848-31228
404872 9650523 Minus 18540-18718
402876 9864669 Plus 5679-6027,74857584
405204 7230116 Plus 126569-126754
402294 2282012 Minus 25753000
400991 8096825 Plus 159197-159320
401284 9800819 Minus 101307-101421
402474 7547175 Minus 5352553628,5575555920,57530-57757
403022 3132351 Plus 92097-92864
402542 9801558 Minus 6707567594
403409 9438598 Plus 6860-7054,12573-12771
403506 7596863 Plus 105005105650
406016 8272661 Plus 41341-41940
405268 4156151 Minus 24404-24521
401106 8568931 Plus 122694-122893
404186 4481839 Plus 829-1110
403817 8962065 Plus 110297-111052
406422 9256411 Plus 163003-163311
402160 8516165 Plus 166063-166354
402622 9930984 Minus 129861-130099
401558 7139678 Plus 103515104090
404960 7408010 Minus 146185146377,147747-147943
401203 9743387 Minus 172961-173056,173865173928
402860 9588237 Minus 7642576560
401588 7230871 Plus 46412-46561
404831 6624702 Minus 16833-17020,20007-20120,2160521799,2333
405885 7677703 Minus 42574-42998
TABLE 50A ABOUT 398 GENES UPREGULATED IN PRIMARY MELANOMAS OR MELANOMA METASTASES RELATIVE TO BENIGN NEVI
Table 50A lists about 398 genes upregulated in pnmary melanoma or melanoma metastases relative to benign nevi Genes were selxted from 59680 probesets on the
Eos/Affymetox Hu03 Genxhip array Gene expression data for exh probeset obtained from this analysis was expressed as average intensity (Al) a normalized value reflxdng the reladve level of mRNA expression
Pkey Unique Eos probeset idendfier number
ExAxn Exempla Axession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene title R1 70th percentile of pnmary melanoma and melanoma metastasis Als divided by the maximum Al of benign nevi
R2 70th percendle of pnmary melanoma and melanoma metastasis Als divided by the maximum Al of benign nevi, where the 15th percendle of normal dssue Als was subtrxted from both the numerator and denominator
Pkey ExAccn UnigenelD Unigene Title R1 R2
422424 AI186431 Hs 296638 prostate differentiation fxtor 1373 1682
446619 AU076643 Hs 313 sxreted phosphoprotein 1 (osteopondn, 11 67 11 84
407846 AA426202 Hs 40403 Cbp/p300-ιnterxdng transxdvator, wit 935 7 59
444381 BE387335 Hs 283713 ESTs, Weakly similar to S64054 hypothed 863 790
417880 BE241595 Hs 82848 selxdn L (lymphxyte adhesion molxule 821 409
424321 W74048 Hs 1 65 lymphxyte-spxific protein tyrosine kin 7 13 610
447210 AF035269 Hs 17752 phosphatidylseπne-spxific phospholipas 679 6 26
417693 AW959741 Hs 40368 adaptor-related protein complex 1 sigma 655 636
429500 X78565 Hs 289114 hexabrxhion (tenascin C, cytotxdπ) 643 7 11
414812 X72755 Hs 77367 monokme induced by gamma interferon 643 7 51
451736 AW080356 Hs 23889 ESTs, Weakly similar to ALU7.HUMAN ALU S 631 4 28
418870 AF147204 Hs 89414 chemokine (C-X-C motif), rxeptor 4 (fus 620 432
428291 AA534009 Hs 183487 interferon stimulated gene (20kD) 603 452
417308 H60720 Hs 81892 KIAA0101 gene product 601 6 78
448569 BE382657 Hs 21486 signal transducer and xdvator of trans 599 7 51
439310 AF086120 Hs 102793 ESTs 595 479
452838 U65011 Hs 30743 preferentially expressed antigen in ela 595 5 55
422241 Y00062 Hs 170121 protein tyrosine phosphatase, receptor t 576 4 82
442379 NM.004613 Hs 8265 transglutaminase 2 (C polypepdde, prote 576 2 19 409274 NM 003930 Hs 52644 SKAP55 homologue 565 463
442739 NM 007274 Hs 8679 cytosolic xyl coenzyme A thioester hydr 558 341
442711 AF151073 Hs 8645 hypothedcal protein 545 579
425118 AU076611 Hs 154672 methylene tetrahydrofolate dehydrogenase 542 556
412918 BE563957 xdvated RNA polymerase II transcnpdo 5 35 431
428125 AA393071 Hs 182579 leucine ammopepddase 533 483
446921 AB012113 Hs 16530 small inducible cytokine subfamily A (Cy 533 513
431183 NM 006855 Hs 250696 KDEL (Lys-Asp-Glu-Leu) endoplasmic rede 530 627
414219 W20010 Hs 75823 ALL1-fused gene from chromosome 1q 516 513
426600 NM 003378 Hs 171014 VGF nerve growth fxtor inducible 505 1372
415444 BE247295 Hs 78452 solute earner family 20 (phosphate tran 503 493
436701 AW959032 ESTs, Moderately similar to I78885 seπn 503 342
406648 AA563730 Hs 277477 major histocompadbility complex, class 499 336
410850 AW362867 Hs 302738 Homo sapiens cDNA FU21425 fis, clone C 498 530
418299 AA279530 Hs 83968 integnn, beta 2 (andgen CD18 (p95), ly 498 485
432469 AL080084 CGI-100 protein 497 446
404854 Target Exon 485 349
415701 NM 003878 HS 78619 gamm---glu.atr.yl hydrolase (coπjugase, fol 482 490
425397 J04088 Hs 156346 topoisomerase (ONA) II alpha (170kD) 481 526
408958 T99607 Hs 49346 signal recognition particle 54kD 4 78 234
453949 AU077146 Hs 36927 heat shxk 105kD 478 5 18
458079 AI796870 Hs 54277 DNA segment on chromosome X (unique) 992 477 4 13
440245 AK001913 Hs 7100 hypothedcal protein 474 332
412228 AW503785 Hs 73792 complement component (3d/Epsteιπ Barr vi 474 1 55
417834 BE172058 Hs 82689 tumor rejxdon andgen (gp96) 1 473 425
451003 AF058696 Hs 25812 Nijmegen breakage syndrome 1 (nibπn) 467 469
424571 BE379766 polymerase (RNA) II (DNA dirxted) polyp 462 302
434203 BE262677 Hs 283558 hypothedcal protein PR01855 461 545
452268 NM 003512 Hs 28777 H2A histone family, member L 4 60 288
421311 N71848 Hs 283609 hypothedcal protein PRO2032 460 324
410491 AA465131 Hs 64001 Homo sapiens ctone 25218 mRNA sequence 460 434
425706 AW406678 Hs 122559 hypothedcal protein FU22570 459 358
450293 N36754 Hs 171118 hypothedcal protein FU00026 457 382
406836 AW514501 Hs 156110 immunoglobulin kappa constant 4 57 927
413441 AI929374 Hs 75367 Src-like-adapter 4 53 360
431129 AL137751 Hs 263671 Homo sapiens mRNA, cDNA DKFZp434l0812 (f 448 4 89
418506 AA084248 Hs 85339 G protein-coupled rxeptor 39 447 372
411060 NM.006074 Hs 318501 Homo sapiens rnRNA full length insert cDN 447 396
417501 AL041219 Hs 82222 sema domain, immunoglobulin domain (Ig), 445 240
437763 AA469369 Hs 5831 dssue inhibitor of metalloproteinase 1 443 427
448883 BE614989 Hs 7503 hypothedcal protein FU14153 442 391
417274 N92036 Hs 81848 RAD21 (S pombe) homolog 441 380
419285 D31887 Hs 89868 KIAA0062 protein 440 320
418321 D63477 Hs 84087 KIAA0143 protein 438 279
430154 AW583058 Hs 234726 senne (or cysteine) proteinase inhibito 437 386
428450 NM 014791 Hs 184339 KIAA0175 gene product 436 465
428297 AA236291 Hs 183583 senne (or cysteine) proteinase inhibito 436 342
447232 AW499834 Hs 327 interieukin 10 rxeptor, alpha 4 36 331
409598 NM 014018 Hs 55097 mitxhondπal nbosomal protein S28 435 3 10
442432 BE093589 Hs 38178 hypothetical protein FU23468 434 561
407047 X65965 gb H sapiens SOD-2 gene for manganese su 4 33 331
443991 NM 002250 Hs 10082 potassium intermediate/small conductance 433 357
452322 BE566343 Hs 28988 glutaredoxin (thioltransferase) 432 220
420991 AW50481 Hs 287379 Homo sapiens mRNA for FU00111 protein, 4 32 360
449722 BE280074 Hs 23960 cycl B1 431 5 79
408380 AF123050 Hs 44532 diubiquidn 430 362
427127 AW802282 Hs 22265 pyruvate dehydrogenase phosphatase 4 28 4 18
417933 X02308 Hs 82962 thymidylate synthetase 4 28 506
432828 AB042326 Hs 287402 chondroidn 4-sulfotraπsferase 425 415
450306 AL080080 Hs 24766 thioredoxin doman-contaming 4 24 3 15
440266 AA088809 Hs 19525 hypothetical protein FU 22794 4 23 365
407951 W77762 Hs 79015 antigen identified by monxlonal andbod 4 22 421
427337 Z46223 Hs 176663 Fc fragment of IgG. low affinity lllb, r 420 4 11
408989 AW361666 Hs 49500 KIAA0746 protein 4 20 426
449626 AA774247 Hs 301637 zinc linger protein 258 4 19 265
422846 BE513934 Hs 1583 neutrophil cytosolic fxtor 1 (47kD, chr 4 18 680
415726 T89844 Hs 78712 aminolevulinate, delta-, synthase 1 4 16 4 28
444207 AI565004 cathepsin D (lysosomal aspartyl protease 4 16 1 89
416980 AA381133 Hs 80684 high-mobility group (nonhistone chromoso 4 14 3 32
438718 AL040058 Hs 6375 uncharxtenzxi hypothalamus protein HT0 4 14 302
437802 AI475995 Hs 122910 ESTs 4 12 4 18
446392 AF142419 Hs 15020 homolog of mouse quaking OKI (KH domain 4 12 387
409461 AA382169 Hs 54483 N-myc (and STAT) interxtor 4 11 380
427247 AW504221 Hs 174103 integnn, alpha L (antigen CD11 A (p180), 4 11 5 71
414359 M62194 Hs 75929 cadheπn 11, type 2, OB-cadhenn (osteob 4 10 425
450071 AA018283 Hs 24359 Homo sapiens cONA FU 11174 fis, done PL 4 10 291
452882 AW972990 Hs 196270 folate transporter/caπer 4 10 4 25
414522 AW518944 Hs 76325 Immunoglobulin J chain 409 399
407756 AA116021 Hs 38260 ubiquidn specific protease 18 409 460
405506 Target Exon 408 364
444677 AL110212 Hs 301005 punne-nch element binding protein B 407 243
417497 AW402482 Hs 82212 CD53 andgen 407 6 55
413715 AW851121 Hs 75497 Homo sapiens cDNA FU22139 fis, clone H 406 327 421508 NM 004833 Hs 105115 absent in melanoma 2 405 439
408688 AI634522 Hs 152925 KIAA1268 protein 405 332
439453 BE264974 Hs 6566 thyroid hormone rxeptor interxtor 13 404 353
445701 AF055581 Hs 13131 lymphxyte Raptor protein 402 420
451131 AI267586 Hs 268012 fatty-xid-Coenzyme A ligase, long-chain 401 396
449291 BE176893 Hs 23440 KIAA1105 protein 401 234
443071 AL080O21 Hs 8986 complement ∞mponent 1, q subcomponent. 400 697
417615 BE548641 Hs 82314 hypoxanthine phosphoπbosyltransferase 1 399 427
408246 N55669 Hs 333823 mitxhoπdπal nbosomal protein L13 398 366
408819 AW163483 Hs 48320 double πng-finger protein, Dorfin 398 376
424058 AL121516 Hs 138617 thyroid hormone rxeptor interxtor 12 397 238
418942 AI566004 Hs 141269 Homo sapiens cDNA FU21550 fis, clone C 397 340
424756 AW504657 Hs 152931 lamin B rxeptor 393 267
421958 AA357185 Hs 109918 ras homolog gene family, member H 389 239
440692 AL031591 Hs 7370 phosphoddylmositol transfer protein, b 388 323
433001 AF217513 Hs 279905 done HQ0310 PRO0310p1 388 424
418255 AW135405 Hs 37251 ESTs 387 253
444371 BE540274 Hs 239 forkhead box M1 386 429
450515 AW304226 biphenyl hydrolase-like (senne hydrolas 385 373
416114 AI695549 Hs 183868 glucuronidase, beta 385 374
440596 H13032 Hs 103378 hypothedcal protein MGC11034 384 1 90
417020 T78413 heterogeneous nuclea nbonucleoprotein 382 204
448503 BE243146 Hs 21332 BTB (POZ) domain contaning 1 381 307
446506 AI123118 Hs 15159 chemokine-like fxtor, alternatively spl 381 369
417059 AL037672 Hs 81071 extrxellular matπx protein 1 380 601
410668 BE379794 Hs 159651 hypothedcal protein 380 522
420107 AL043980 Hs 7886 pellino (Drosophila) homolog 1 379 393
446071 N51527 Hs 13659 hypothedcal protein OKFZp586F2423 379 274
419731 S47242 Hs 92909 SON DNA binding protein 377 1 85
443710 AI928136 Hs 9691 Homo sapiens cDNA FU23249 fis, ctone C 377 498
406837 R70292 Hs 156110 immunoglobulin kappa constant 377 742
436481 AA379597 Hs 5199 HSPC150 protein similar to ubiquidn-con 376 355
419381 AB023420 Hs 90093 heat shxk 70kD protem 4 376 381
423979 AF229181 Hs 136644 CS box-containing WD protein 376 397
402474 NM.004079 Homo sapiens cathepsin S (CTSS 376 401
412828 AL133396 Hs 74621 pπon protein (p27-30) (Creutzfeld-Jakob 375 377
454080 AI199711 Hs 576 fucosidase, alpha-L- 1, dssue 374 6 15
408085 N25929 Hs 342849 ADP-nbosyladon fxtor-like 5 374 292
426096 D87436 Hs 166318 lipin 2 372 298
417105 X60992 Hs 81226 CD6 andgen 372 278
418322 AA284166 Hs 84113 cyclm-dependent kinase inhibitor 3 (CDK 372 337
447735 AA775268 Hs 6127 Homo sapiens cDNA FU23020 fis clone L 370 409
409264 NM 014937 Hs 52463 KIAA0966 protein 369 479
429170 NM.001394 Hs 2359 dual specificity phosphatase 4 369 294
428398 AI249368 Hs 98558 ESTs 368 382
423494 AW504365 Hs 24143 Wiskott-Aldπch syndrome protein interx 367 352
413235 BE243445 Hs 75248 topoisomerase (DNA) II beta (180kD) 367 279
423712 W46802 Hs 81988 disabled (Drosophila) homolog 2 (mitogen 366 342
409703 NM 006187 Hs 56009 2-5'-olιgoadeπylate synthetase 3 (100 k 366 644
447225 R62676 Hs 17820 Rho-assxiatxi, coiled-coil containing p 365 293
414829 AA321568 Hs 77436 plxkstπn 365 2 30
400219 Eos Control 364 276
437239 AW503395 Hs 5541 ATPase, Ca transporting, ubiquitous 363 273
422445 M23114 Hs 1526 ATPase Ca transporting, cardix muscle, 362 360
449971 AA807346 Hs 288581 Homo sapiens cONA FU14296 fis, clone PL 362 362
424460 BE275979 Hs 296014 polymerase (RNA) II (DNA directed) polyp 362 306
427609 AK000436 Hs 179791 hypothedcal protein FU20429 362 2 31
400750 Taget Exon 361 274
424541 AW392551 Hs 180559 ESTs, Weakly simila to A56194 thromboxa 361 225
427051 BE178110 Hs 173374 Homo sapiens cDNA FLJ10500 fis, clone NT 360 4 20
433867 AK000596 Hs 3618 hippxalcin like 1 359 4 19
421986 AL137438 Hs 110454 SEC15 (S cerevisiae)-like 359 1 58
414841 H55601 Hs 77490 glutathione S-transferase theta 1 358 1 00
429693 BE254962 Hs 211612 SEC24 (S cerevisiae) related gene famil 3 57 300
425204 NM 002436 Hs 1861 membrane protein, palmitoylated 1 (55kD) 356 309
441669 R78Ϊ95 Hs 29692 Homo sapiens cDNA FU11436 fis, clone HE 356 326
442043 BE567620 Hs 99210 ESTs 3 55 356
406636 L12064 gb Homo sapiens (clone WR4 12VL) aπd-th 355 383
446341 AL040763 Hs 310735 ESTs. Moderately similar to ALU7.HUMAN A 3 54 352
432485 N90866 Hs 276770 CDW52 antigen (CAMPATH-1 andgen) 354 466
422765 AW409701 Hs 1578 bxuloviral IAP repeat-contamπg 5 (sur 354 325
412630 AA738437 Hs 26226 Homo sapiens cDNA FU21286 fis, clone C 354 1 87
432841 M93425 Hs 62 protein tyrosine phosphatase, non-rxept 353 396
425177 AF127577 Hs 155017 nuclear rxeptor interxdng protein 1 353 340
426643 AA857131 Hs 171595 HIV TAT spxific fxtor 1 351 2 21
420137 AA306478 Hs 95327 CD3D antigen, delta polypepdde (TιT3 co 351 251
429248 U96759 Hs 198307 von Hippel-Liπdau binding protein 1 351 285
452852 AK001972 Hs 30822 hypothetical protein FU11110 351 2 71
451791 Z78407 Hs 27023 vesicle transport-related protein 349 291
418310 AA814100 Hs 86693 ESTs 349 1 45
406868 AA505445 Hs 300697 immunoglobulin heavy constant gamma 3 (G 348 681
400200 NM.002788" Homo sapiens proteasome (pros 348 2 51
438746 AI885815 Hs 184727 Human melanoma-assxiated antigen p97 (m 347 694 441646 AB023169 Hs 7935 KIAA0952 protem 347 338
427968 AI857607 Hs 181301 cathepsin S 345 2 71
440201 AL359588 Hs 7041 hypothetical protein DKFZp762B226 345 345
434608 AA805443 Hs 179909 hypothedcal protein FU 22995 344 368
427527 AI809057 Hs 153261 immunoglobulin heavy constant mu 344 670
413385 M34455 Hs 840 iπdoleamine-pyrrole 2,3 dioxygenase 344 272
435550 AI224456 Hs 324507 H sapiens polyA site DNA 343 276
453857 AL080235 Hs 35861 DKFZP586E1621 protein 343 364
423392 AA195037 Hs 169341 HTPAP protein 343 229
418460 M26315 Hs 85258 CD8 andgen, alpha polypepdde (p32) 343 278
453915 AA588721 Hs 286218 πbosomal protein L44 341 306
442485 BE092285 Hs 29724 hypothedcal protein FU13187 341 423
432606 NM 002104 Hs 3066 granzyme K (senne protease, granzyme 3, 340 393
417410 AFG63020 Hs 82110 PC4 and SFRS1 interxdng protein 1 340 2 12
436810 AA353044 Hs 5321 ARP3 (xdn-related protein 3, yeast) ho 340 470
422545 X02761 Hs 287820 fibronxtm 1 339 758
409142 AL136877 Hs 50758 SMC4 (structural maintenance of chromoso 336 412
434826 AF155661 Hs 22265 pyruvate dehydrogenase phosphatase 334 505
448410 AK000227 Hs 21126 hypothedcal protein FU20220 333 431
416065 BE267931 Hs 78996 proliferating cell nuclear andgen 333 60
432642 BE297635 Hs 3069 heat shxk 70kD protein 9B (mortalιn-2) 332 449
425234 AW152225 Hs 165909 ESTs, Weakly similar to I38022 hypothed 324 4 22
443623 AA345519 Hs 9641 complement component 1, q subcomponent 323 1231
426490 NM 001621 Hs 170087 aryl hydrocarbon rxeptor 323 507
443958 BE241880 Hs 10029 cathepsin C 3 16 497
412577 Z22968 Hs 74076 CD163 andgen 314 475
414050 NM 004766 Hs 75724 coatomer protein complex, subunit beta 2 313 400
421633 AF121860 Hs 106260 sorting nexin 10 3 12 445
413936 AF113676 Hs 297681 senne (or cysteine) proteinase inhibito 311 400
428797 AA496205 Hs 193700 Homo sapiens mRNA, cDNA DKFZp586l0324 (f 3 10 403
430314 AA369601 Hs 239138 pre-B-cell colony-enhancing fxtor 306 449
430413 AW842182 Hs 241392 small inducible cytokine A5 (RANTES) 304 498
418526 BE019020 Hs 85838 solute earner family 16 (monxarboxylic 303 449
452139 AA099969 Hs 16331 Homo sapiens cDNA FU21482 fis, clone C 301 475
439237 AW408158 Hs 318893 ESTs, Weakly similar lo A47582 B-cell gr 295 555
422684 BE561617 Hs 119192 H2A histone family, member Z 294 464
406782 AA430373 gb zw20f11 s1 Soares ovary tumor NbHOT H 293 1028
438549 BE386801 Hs 21858 tnnucleodde repeat containing 3 291 540
450455 AL117424 Hs 25035 chlonde intracellular channel 4 290 486
427528 AU077143 Hs 179565 minichromosome maintenance deficient (S 289 404
422530 AW972300 Hs 118110 bone maπow stromal cell antigen 2 287 961
423605 AF047826 Hs 129887 cadhenn 19, type 2 283 486
410231 AA314163 Hs 61153 proteasome (prosome, mxropan) 26S subu 282 502
419956 AL137939 Hs 40096 cadhenn 19, type 2 280 430
416511 NM 006762 Hs 79356 Lysosomal-assxiated muldspannmg membr 2 79 580
429732 U20158 Hs 2488 lymphxyte cytosolic protein 2 (SH2 doma 278 421
448517 AA082750 Hs 42194 hypothedcal protein FU22649 similar to 278 423
416784 AA334592 Hs 79914 lumican 278 440
427792 M63928 Hs 180841 tumor nxrosis fxtor rxeptor superfami 277 4 23
412140 AA219691 Hs 73625 RAB6 interxdng, kinesin like (rabkmes 277 4 17
427080 AW068287 Hs 301175 ras-related C3 botulmum toxin substrate 276 443
446272 BE268912 Hs 14601 hematopoietic cell-spxific Lyn substrat 275 4 20
437179 AA393508 serologically defined colon cancer andg 274 407
429402 AF116571 Hs 201671 SRY (sex determining region Y)-box 13 272 463
421360 AA297012 Hs 103839 erythrocyte membrane protein band 4 1-lι 271 493
409202 AA236881 Hs 51043 hexosammidase B (beta polypepdde) 268 415
426124 AI268389 Hs 250697 phosphaddylmositol glycan, class F 268 400
422672 X12784 Hs 119129 ∞llagen, type IV, alpha 1 267 472
417389 BE260964 Hs 82045 midkme (neunte growth-promodng fxtor 265 7 77
409415 AA579258 Hs 6083 Homo sapiens cDNA FU21028 fis, clone C 265 447
410341 AW499985 Hs 42915 ARP2 (xdn-related protein 2, yeast) ho 264 561
433027 AF191018 Hs 279923 putadve nucleotide binding protein, est 263 434
424687 J05070 Hs 151738 matπx metalloproteinase 9 (gelabnase 8 262 495
409430 R21945 Hs 346735 splicing fxtor, argmine/senne-πch 5 260 600
424779 AL046851 Hs 153053 CD37 antigen 260 427
409354 N68188 Hs 159472 Homo sapiens cDNA FU22224 fis, clone H 260 464
427550 BE242818 Hs 311609 nuclear RNA helicase, DECD vanant of DE 257 4 27
426143 BE379836 proteasome (prosome, mxropan) subunit 256 420
421563 NM.006433 Hs 105806 granulysin 256 4 13
425593 AA278921 Hs 1908 proteoglycan 1, sxretorγ granule 255 546
428169 AI928984 Hs 182793 golgi phosphoprotein 2 254 578
429800 AA333375 Hs 223014 antizyme inhibitor 250 5 15
407241 M34516 gb Human omega light chain protein 14 1 250 498
421739 AB004550 Hs 107526 UDP-Gal betaGlcNAc beta 1 ,4- galxtosylt 245 558
412819 T25829 Hs 24048 FK506 binding protein precursor 245 7 20
412025 AI827451 Hs 24143 Wiskott-Aldnch syndrome protein interx 244 4 11
435523 T62849 Hs 11090 membrane-spanning 4-domaιns, subfamily A 244 467
445350 AF052112 Hs 12540 lysophospholipase 1 244 544
449296 AL137257 Hs 23458 Homo sapiens cDNA FU23015 fis, clone L 241 431
440065 W03476 Hs 266331 hypothetical protein MGC4595 241 4 25
400223 Eos Control 239 568
422658 AF231981 Hs 250175 homolog of yeast long chan polyunsatura 239 662
431629 AU077025 Hs 265827 interferon, alpha-mducible protein (do 238 722 414622 AI752666 Hs 76669 nicodnamide N-methyltransferase 238 521
415149 X12451 Hs 78056 cathepsin L 237 771
435099 AC004770 Hs 4756 flap structure-spxific endonuclease 1 237 568
427407 BE268649 Hs 177766 ADP-πbosyltransferase (NAD, poly (ADP-r 231 489
426432 AF001601 Hs 169857 paraoxonase 2 229 483
430555 AI815486 Hs 243901 Homo sapiens cDNA FU20738 fis, clone HE 227 503
413869 NM 000878 Hs 75596 interieukin 2 rxeptor, beta 225 414
412617 AK001364 Hs 808 heterogeneous nuclea πbonucleoprotein 221 431
447547 NM 007229 Hs 18842 protein kinase C and casein kinase subst 2 19 462
416232 AW502678 Hs 79090 exportin 1 (CRM1, yeasL homolog) 2 18 484
420842 AI083668 Hs 50601 hypothetical protein MGC10986 2 14 422
411358 R47479 Hs 94761 KIAA1691 protein 2 13 465
428227 AA321649 Hs 2248 small inducible cytokine subfamily B (Cy 2 13 403
406687 M31126 matπx metalloproteinase 11 (stromelysm 2 11 4 16
417331 AW411297 Hs 81972 SHC (Src homology 2 domain-containing) t 2 11 425
450344 AW994032 Hs 8768 hypothedcal protein FU 10849 2 11 409
429642 X68264 Hs 211579 melanoma cell adhesion molxule (MCAM) ( 211 542
416448 L13210 Hs 79339 lectin, galxtoside-binding, sduble, 3 210 642
418613 AA744529 Hs 86575 mitogen-xdvated protein kinase kinase 2 10 400
453352 T10446 ESTs 209 448
409220 BE243323 Hs 51233 tumor nxrosis fxtor rxeptor superfami 209 498
414045 NM 002951 Hs 75722 πbophoπn II 207 459
422451 AA310753 Hs 42491 ESTs, Weakly similar to S65657 alpha-1 C- 207 409
414085 AA114016 Hs 75746 aldehyde dehydrogenase 1 family, member 206 506
452363 AI582743 Hs 94953 Homo sapiens, Similar to complement comp 204 11 17
438393 AA351815 Hs 50740 Homo sapiens cDNA FU22272 fis, clone H 203 436
413313 NM 002047 Hs 283108 glycyl-tRNA synthetase 202 479
412994 032257 Hs 75113 general transcnpdon fxtor IIIA 200 467
424415 NM.001975 Hs 146580 enolase 2, (gamma, neuronal) 1 98 479
421897 AW583693 Hs 109253 N-terminal acetyltransferase complex a 1 98 4 17
442159 AW163390 Hs 278554 heterochromadn-like protein 1 1 95 753
429451 BE409861 Hs 202833 heme oxygenase (dxycling) 1 1 95 463
416967 BE616731 Hs 80645 interferon regulatory fxtor 1 1 95 431
400203 Eos Control 1 94 503
437317 AA748613 Hs 311977 ESTs, Highly similar to SWI/SNF related, 1 94 403
414945 BE076358 Hs 77667 lymphxyte antigen 6 complex, Ixus E 1 93 468
416224 NM.002902 Hs 79088 redculxalbm 2, EF-hand calcium bindm 1 92 412
445411 AL137255 Hs 12646 hypothedcal protein FU22693 1 91 423
413945 NM 000591 Hs 75627 CD 14 antigen 1 90 500
413317 U53225 Hs 75283 sorting πexin 1 1 89 4 20
448719 AA033627 Hs 21858 tnnucleotide repeat contaning 3 1 89 4 26
430838 N46664 Hs 169395 hypothetical protein FU12015 1 88 4 15
427239 BE270447 ubiquitin earner protein 1 87 572
450440 AB024334 Hs 25001 tyrosine 3-monooxygenase/tryptophan 5mo 1 87 581
433671 AW138797 Hs 132906 19A24 protein 1 85 4 27
413190 AA151802 Hs 40368 adaptor-related protein complex 1, sigma 1 85 519
414915 NM 002462 Hs 76391 myxovirus (influenza) resistance 1, homo 1 85 431
430040 AW503115 Hs 227823 pM5 protein 1 83 557
417929 R27219 Hs 74647 Human T-cell rxeptor xdve alpha-chain 1 82 429
414570 YO0285 Hs 76473 insulin-like growth fxtor 2 receptor 1 81 439
414416 AW409985 Hs 76084 hypothedcal protein MGC2721 1 80 4 20
428977 AK001404 Hs 194698 cyclm B2 1 79 4 17
418707 U97502 Hs 87497 butyrophilm, subfamily 3, member A2 1 78 430
425367 BE271188 Hs 155975 protein tyrosine phosphatase, receptor t 1 8 544
425811 AL039104 Hs 159557 karyopheπn alpha 2 (RAG cohort 1, impor 1 77 5 11
422009 AI742845 Hs 110713 DEK oncogene (DNA binding) 1 77 437
424909 S78187 Hs 153752 cell division cycle 25B 1 74 500
409154 U72882 Hs 50842 interferon-induced protein 35 1 74 486
413892 AI878921 Hs 75607 mynstoylated alanine-nch protein kmas 1 73 437
444954 AW247076 Hs 12163 eukaryotic translation initiation fxtor 1 71 502
424263 M77640 Hs 1757 L1 cell adhesion molxule (hydrxephalus 1 70 468
424825 AF207069 Hs 153357 procollagen-lysme, 2-oxoglutarate 5dιo 1 70 459
427378 BE515037 Hs 177556 melanoma andgen, family D, 1 1 67 559
413322 AA380158 Hs 75290 ADP-πbosyladon fxtor 4 1 67 439
442414 BE408758 Hs 8297 nboπuclease 6 precursor 1 65 403
410129 BE244074 Hs 58831 regulator of Fas-induced apoptosis 1 64 4 24
422976 AU076657 Hs 1600 chaperonin containing TCP1, subunil 5 (e 1 64 491
443051 AA333660 Hs 71331 hypothedcal protein MGC5350 1 64 408
452472 AW957300 Hs 294142 ESTs, Weakly similar to C55663 odgodend 1 63 441
446143 BE245342 Hs 306079 sx61 homolog 1 62 470
431142 AA852596 Hs 250641 tropomyosin 4 1 62 486
407752 AA573581 Hs 13328 ESTs 1 62 4 19
416322 BE019494 Hs 79217 pyrrolιne-5-caboxylate reductase 1 1 61 4 51
414572 AU077174 Hs 288181 cathepsin H 1 60 525
415017 F06434 Hs 77805 ATPase, H transporting, lysosomal (vxuo 1 60 456
452056 AW955065 Hs 101150 Homo sapiens, clone IMAGE 4054156, mRNA, 1 58 546
413976 BE295452 Hs 75655 prxollagen-proline, 2-oxoglutaate 4-dι 1 58 405
414420 AA043424 Hs 76095 immediate early response 3 1 58 400
419638 N46504 Hs 91747 profilm 2 1 57 5 57
422624 BE616678 Hs 76152 KDEL (Lys-Asp-Glu-Leu) endoplasmic rede 1 57 444
415819 AU077330 transcπption elongation fxtor A (SH). 1 55 489
439627 BE621702 Hs 29076 hypothetical protein FU21841 1 55 666
425243 N89487 Hs 155291 KIAA0005 gene product 1 54 438 424799 BE550723 Hs 153179 fatty xid binding protein 5 (psoπasis- 1 53 422
416971 R34657 Hs 80658 uncouplmg protein 2 (mitxhoπdπal, pro 1 53 741
426059 BE292842 Hs 166120 interferon regulatory fxtor 7 1 51 4 12
418879 AW162087 Hs 5437 Taxi (human T-cell leukemia virus type I 1 50 402
432999 BE294029 Hs 279903 Ras homolog enπched in brain 2 1 50 4 18
415661 AF057307 Hs 78575 prosaposm (vanant Gaucher disease and 1 49 419
428098 AU077258 Hs 182429 protein disulfide isomerase-related prot 1 49 574
452264 AU077013 Hs 28757 transmembrane 9 superfamily member 2 1 48 453
415198 AW0O9480 Hs 943 natural killer cell transcnpt 4 1 47 495
411794 AL118577 Hs 75658 phosphorylase, glycogen, bran 1 45 461
433271 BE621697 Hs 14317 nucleolar protein family A member 3 (H/ 1 45 4 15
421416 BE302950 Hs 104125 adenylyl cyclase-assxiated protein 1 42 467
415089 N25117 Hs 299465 πbosomal protein S26 1 41 519
421975 AW961017 Hs 6459 hypothedcal protein FU11856 1 41 403
400202 NM.002795" Homo sapiens proteasome (pros 1 41 444
413278 BE563085 Hs 833 interferon-stimulated protein 15 kDa 1 41 457
412968 AW500508 Hs 75102 alanyl-tRNA synthetase 1 40 425
440704 M69241 Hs 162 insulin-like growth fxtor binding prote 1 39 4 11
447099 AB030656 Hs 17377 coronin, xdn-bmding protein, 1C 1 39 451
428511 AA019912 Hs 184693 transcnpdon elongadon fxtor B (Sill) 1 38 490
413825 BE299181 Hs 75564 CD151 andgen 1 37 444
441737 X79449 Hs 7957 adenosine deaminase, RNA-spxific 1 36 429
440087 W28969 Hs 7718 hypothedcal protein FU22678 1 36 410
413566 AW604451 Hs 285814 sprouty (Drosophila) homolog 4 1 35 450
413019 BE281604 Hs 75140 low density lipoprotein-related protein- 1 35 514
433026 AW160616 Hs 279921 HSPC035 protein 1 35 4 14
427380 NM 005534 Hs 177559 interferon gamma rxeptor 2 (interferon 1 34 435
428289 M26301 Hs 2253 ∞mplement component 2 1 33 423
419715 AF070523 Hs 92384 vitamin A responsive, cytoskeleton relat 1 32 461
425299 AW505214 Hs 155560 calnexm 1 31 476
422242 AJ251760 Hs 273385 guanine nucleotide binding protein (G pr 1 30 530
448483 AA356392 Hs 21321 Homo sapiens clone FLB9213 PR02474 mRNA 1 29 609
407143 C14076 Hs 332329 EST 1 29 456
413125 BE244589 Hs 75207 glyoxalase 1 1 26 5 56
439053 BE244588 Hs 6456 chaperonm containing TCP1, subunit 2 (b 1 26 498
413929 BE501689 Hs 75617 collagen, type IV, alpha 2 1 25 476
419663 AA394208 Hs 92198 calcium-regulated heat-stable protein (2 1 24 456
422166 W72424 Hs 112405 S100 calcium-binding protein A9 (calgran 1 21 896
416636 N32536 Hs 42645 solute earner family 16 (moπxarboxylic 1 21 402
425335 BE394327 Hs 296267 follistadn-hke 1 1 18 429
446211 AI021993 Hs 14331 S100 calcium binding protein A13 1 17 432
428642 NM.014899 Hs 10432 KIAA0878 protein 1 13 4 17
454117 BE410100 Hs 40368 adaptor-related protein complex 1 , sigma 1 10 400
428216 M18468 Hs 183037 protein kinase, cAMP-depeπdent regulato 1 09 440
431211 M86849 Hs 323733 gap juncdon protein, beta 2 26kD (∞nn 1 00 470
422158 L10343 Hs 112341 protease inhibitor 3, skm-denved (SKAL 098 440
408522 AI541214 Hs 46320 Small proline-πch protein SPRK [human, 090 478
TABLE 50B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accessior i Genbank axession numbers
Pkey CAT Number Accession
412918 2764.3 BE784583 AL519009 AV755430 AV756363 AV711927 BI523434 AI5.
AA946555 AA723580 AA612925 BG105326 BG532618 AW513994 AW602165 AI373448 AA907901 AW135104 BG186662 W69205 BG219754 BE774875 BG190378 AA483698 BE066066 BE066067 BE066062 AW304207 BE939361 AW795569 BG210592 AW795644 BE939358 AW102886 BE065977 BG182971 H97042 D58090 BI046351 H81248 AI750112 AW372079 C05492 D58287 D57835 AA935095 BF700910 BG215802 BG195459 AW3684678G495535 BG533177 BI087962 BE541579 BF130753
436701 28142.1 Z69892 AA210833 BM353155 AI473754 AI147901 AI803109 AA843296 AA418925 AI478552 AI400067 AI360304 AA418828 AW301673 BE218952
AI632804 BF433234 AA394157 BF378047 BE467036 AA319724 AW290940 AI222671 AI347724 AW001711 AI028652 AA398130 AI470582 AI915936 AA908929 C75102 N36920 H50440 AI919034 AI004399 AI383862 AI123606 AA648518 AA516258 AI865321 N22865 AA848101 AI589792 AA758196 AA214630 AI373911 AW194733 AA213447 AI290291 BF437165 AA757592 BF086904 AW959032 AW992466 BF446888 AI936337 BE938849 AW149064 AI701629 N90021
432469 58644.1 BC016556 BC016365 NM.016040 AF151858 BI561037 AW966873AW967497 BE219482 BE018650AW770511 AW469095AW470133 BM150181
BM193977 AI824135 AI632346 AI129838 BM147664 AI292112 BE244667 AA251084 AW503659 BM193866 BM194481 BF446862 AL597435 BF000262 AI824386 AI990100 AW087624 AA668793 AL080084 BI335866 BI820940 BG779242 BM069854 AA282620 AA256771 AW964511 AA451623 H00335 AW370399 AW954201 BM145846 BG111760 AI750065 BG655794 AA564086 BG494071 BM069606 AI675331 BE302224 AI476466 AI625980 BM144854 AI184602 AI343932 AW136586 AW029464 AI708651 AA824243 BM145917 AA662210 AA825708 AI335858 AI273704 AA662171 N48971 AA976614 AI344537 AA609603 AI873901 AI859995 AA833589 AA765811 AI150322 AI926816 BM148634 N98862 AA019347 AA897062 AA831100 N69889 BE243185 AA282179 AA831098 AA112676 AI702407 BG621752 BE006492 AA353202 BG674256 N46921 BI048774 AW300233 BF739890 AW966879 AA393405 BF115146 AA910851 AA013099 N28878 AA287713 BE348728 BG616446 AL599953 AL599952 BF381073 AW505056 AA094735 H03613 AA287714 H27168 R54718 BF792697 AV693603 AV685883 BG619956 BF541504 BF216789 AA319751 BM452652 BF335838 AA280397 BG171509 BF571997 AA490239 AW388161 BE842126 BG165309 N71903 AI955397 AI536898 BE242040 F09718 AA772421 AA450218 M78543 BE241414 AA013098 H00297 AW576477 AW150918 AW591371 AI382711 N71926 H72497 AI285602AA745055 AI281647 BF377670T65207 BG532880 BG721680 AA285143 H27167 AW500235 BG494497 BF668899
424571 9758.1 BE379766 AW152643 AI803450 AI564343 AI092711 AI140525 AW152156 AI620740 AI554689 AI161209 AI290242 AI339745 AI374611 AI347388
AI858296 AI140529 AI366124 AA493912 AA406235 AA493889 AI057160 AW022264 AI097277 AI144126 AI080051 AA983529 AA860507 N53469 AA843767 N81163 N70628 AA424577 AA983537 BF003004 AA626688 AA235977 AI057152 AI095366 AI095356 AA458646 AW194479 AA150439 AI375272 AW571777 AI359198 AA993793 BE614394 BE738239 AA127883 AI034344 T59504 D81608 AA908704 AW051665 AA382785 AA307208 N24639 AI370715 BE244980 AA548596 AW449675 AI191008 BF223749 N70752 N22266 AI191012 AA028001 AI419106 BF215661 BF591548 BG942356 AI474968 BE858217 BF793358 AV756758 BG483603 AI093724 BF693395 BG545345 AI744294 T59549 AA811773 BG499757 444207 9172 3 BE739425 AA514221 AA865491 AI828293 AA470456 AI276739 AA169357 BE932464 AA514889 AW819039 AW819083 BE843048 AI432496 AI470335
AI247243 BG533994 AA513783 AI887309 AA528036 AW972006 AW873028 AI924914 AI818810 AW152378 AW084946 AI521413 AI669583 BE932521 AI581370 BE180238 AW089750 AW771461 AW089714 AI590949 AI819148 AA731056 BF815234 BF911506 AA235803 AA485373 AI735658 AW393133 AW073080 AI707637 BF353320 BE843111 AW819036 AW393135 BG697291 AV648670 AV654332 AV687530 BG566964 AI807430 AI676072 AA837010 AI452482 AI625817 AW241750 BE048616 AI290928 AI680714 AA485530 BE175687 AV648513 AW130312 AI000556 AA632893 BE674169 BF001208 AA948166 BE175650 AA524664 AA490345 AI244948 AA602956 AA483492 AA918178 AW802049 BG675859 AV658871 BG678060 AI565004 AW819026 BE843092 AV686437 AV723049 BG616948 AI911647 AI743490 AI091096 BE857251 AI962074 AA040027 AW769317 AA343477 AA640112 BF876213 R82948 H26425 H82876 BE843095 BE843140 BG536641 BG617830 AA235802 BE774985 BE006682 BF342375 AA903144 BF338083 BF984258 AV657996 AI749532 BE768614 BE857252 BE932516 BE768573 AV657993 AV657777 AV752631 BE774974 T55847 BF095761 BF911511 BE710793 BE180119 BG617338 H45942 T55897 AV657718 BG563497
450515 13638.2 BE299605 AI589870 AA847598 AI470122 BF939896 AI304356 BE223045 BF435800 AI394207 AI708171 AW025415 AI079409 AW008420 AW304226
N34543 AW603578 AA526961 AA983631 N99134 AA626645 R45023 AA902417 AW672925 AA449985 AA953982 AW675471 AA01OO62 N80194 H14620 H28475 H26247 BF333581 AW842369 H06848 H05608 H81745 H15016 R51905 AA860423 AI860904 AA876023
417020 74857.1 AK024824 BI089104 AL596792 AI880004 BF969921 BE349489 AA843097 AI475644AW576123AW731676 AI339951 AI128503AW243903BG231992
BG057353 AA987811 AA575927 AI889162 N68847 AA464693 AA962541 AA844323 AI969578 AI830997 AW731626 H77926 AI338984 R24078 AI128953 T88696 AA808038 AA694545 H02091 BF439007 AI189805 AI279912 AA730423 R26552 AA455017 AI264219 AI446015 R19187 D51331 T24484 AI522034 AV721528 BI056340 BG009879 AW371368 Z36733 BE707682 BG501334 BG180238 BE177547 H48381 BF055495 AI948528 AW994256 BF109394 AI817046 W58758 H48807 H01994 T78413 BG750345 R24132 N92060 R25367
400219 8366 1 BC003552 L10284 NM.001746 AJ271880 BI834281 BI597016AU133331 BI668332 B1463073 BG720694 AL046729 BI460138 BI461052 AV647588
BG823268 AW889757 BE001258 AA312566 AA476446 AU098976 AA312196 BF749977 M94859 AF070646 BG564196 BG623597 AU117332 BG680963 BI667083 AU134542 AU138830 AI761759 BG679882 AA209406 AW512644 AW514813 AI570535 BE547592 BG655418 AI459204 BF725673 BE870032 BF001968 AL047245 BF724470 BF058818 H18415 BE076849 BE076857 BE076848 BE076827 BE076856 AV708687 AA380923 BE076851 F08118 L18887 BF795701 AU128383 BE908383 AW673350 AW500108 BE079837 BE929419 BF868758 AW503373 AW580528 BE005524 BI917505 BI457781 BE883812 BI668159 AA213643 AA374821 BF969974 BM480200 AU136152 BE395635 AV685066 AV693755 AL040984 AA676820 BG896408 BE082272 BE082312 C05287 BE082264 AA379850 AW672902 AI625955 BF033526 AW296557 AA728815 BE077058 AW081700 AA911707 AA362640 BE707179 BG913228 BG116191 BG752367 AA074678 AL036937 BG113760 H03524 BG681802 AI564688 AU149556 BE178600 AI813488 AI452433 AI208989 AA599392 AA580385 AA486274 AA629899 AA565929 AA114046 AA094252 BM450328 BG529968 R68320 BE076792 8E090073 BE076855 BE076859 BE076829 AA361719 AA379164 AI202712 BG223315 BE122741 BG534531 AA903494 H24978 BF032674 BF085150 BE739158 AA352904 C21593 BG697597 AA134969 AA374612 BE566182 BE871838 BE076911 AW579175 BF966390 BI548594 BG386452 BG913195 BM456787 N40286 T80096 N39642 H42119 BG483861 AW381621 R69347 AW128895 AI367416 AI095285 AA099344 BE568161 AA180109 BF246488 BI561938 AW579170 BG567212
406636 0.0 L12064 L12083 L12065 L12075 L12066 L12085 L12072 L12082 L12081 L12062 L12080
400200 3806.1 BC005265 BG176720 AW006027 BM352064 AW026316 AI635822 AI880584 AI693769 AI092211 BI492387 AI400449 AW166297 BF939910 AA232282
AW021432 AI333893 AA494308 AA854899 AI436795 AW069256 AA682373 AI092748 AA993184 AI126077 AI081758 AI240686 AI261863 AI378423 AA465237 AI376096 AA035579 AI087306 AA448162 AA129977 AI090903 AI080686 AI288939 N33004 AI801240 AW021546 AI370773 AI086064 AA669528 AI250053 AI870113 AA853181 AA858014 BG055562 BG939559 AW080765 AA032283 AW467587 H40506 D00762 NM.002788 AA641134 AI582295 AI417525 AI563975 AI093566 AI707743 AI290741 AW073417 BE875418 BM264076 BG876884 AI680535 AW854219 BE774635 AW854212 BG952443 AW854221 AW854208 BE156348 BE843056 AW858991 BE937569 BG878291 BG876450 AW819099 AI908570 AA449871 AU135228 BM478404 BF126296 AA375499 AA248473
406782 0.0 AA430373 AA968771 437179 12239.1 AK055109 BC019085 AA187684 BG656226 BM023227 AI932311 AW264381 AA398371 BM021483 AI432433 AI375777 AI129580 AW262782 AA134107 BM023515AA977504AI859222 AI348454 R69725 AA975268 BM021207 AL080074AA129218 AW207842 N90581 AA771919 AI092259 AI028416 AI074114 BG656536 BE501677 AW193419AA917040W90430 AI342984 AI378957 AL036486 AW020068 BI491093 BF476021 R41226 R69631 F04125 C02343 AA115589 R56480 AI400988 R54266 R31422
426143 3806.1 BC005265 BG176720 AW006027 BM352064 AW026316 AI635822 AI880584 AI693769 AI092211 BI492387 AI400449 AW166297 BF939910 AA232282 AW021432 AI333893 AA494308 AA854899 AI436795 AW069256 AA682373 AI092748 AA993184 AI126077 AI081758 AI240686 AI261863 AI378423 AA465237 AI376096 AA035579 AI087306 AA448162 AA129977 AI090903 AI080686 AI288939 N33004 AI801240 AW021546 AI370773 AI086064 AA669528 AI250053 AI870113 AA853181 AA858014 BG055562 BG939559 AW080765 AA032283 AW467587 H40506 D00762 NM.002788 AA641134 AI582295 AI417525 AI563975 AI093566 AI707743 AI290741 AW073417 BE875418 BM264076 BG876884 AI680535 AW854219 BE774635 AW854212 BG952443 AW854221 AW854208 BE156348 BE843056 AW858991 BE937569 BG878291 BG876450 AW819099 AI908570 AA449871 AU135228 BM478404 BF126296 AA375499 AA248473
400223 2368.1 NM.005648 BC013809 L34587 BF103775 BG702618 BG716553 BI667090 BG505863 BF983483 BG718195 BI857891 BG501016 BM043599
AL521812 BG705730 BI495545 BI495546 BF112248 BM023182 BM023123 AI075173 AW051799 BF058224 BI324885 BF436008 AA398446 BG822375 BM019558 BM023382 BG164174 N56909 BI467064 BM023464 AI207475 BM311415 BG758430 BG758807 AI934826 N90351 BG422026 BE910312 AI027778 AI081950 AI3608908M009115 AI191829 BG759697 AI138728 AA399403 AI355589 AI336427 AA868702 AA393660 AA025127 BG027630 AA962774 AA631224 BG940967 BE791087 AA573315 W81685 AA393525 BG944103 AI339125 Al 149864 AA977655 N90314 BE612839 BG491847 AI129091 AA461234 AA781198 AA759256 AA888954 AA975844 AI184099 AI018025 AA398363 AI0O3331 AI193380 AA626020 AI244476 AI601114 AW135664 AI206607 AW263599 AA813219 AI684453 AA878626 AA772222 AI085496 AI630226 BG940966 AI022010 AA770649 AA887624 AA491739 AA974295 BG530040 AA037091 AA019912 BI160457 H64512 BG503896
406687 0.0 M31126 453352 12299.2 BG619646 AA367158 BI850421 AW998556 BF107010 BF969630 BF185964 AA361080 AW960026 AA147486 AI807023 AW770262 BI492178 BM145577 AA829932 AW021238 AW629477 AI337862 AI457141 BI712705 BM194542 BI712465 AI380070 N27407 AI609764 AI274152 AI206228 AI076874 AI261827 AI610982 AI469158 AI420690 AI168768 AA491675 C16249 C16232 C16209 C16275 C16274 C16243 R23287 BF246254 R66736 R23212C14593
400203 11774.1 NM.002794 D26599 BM469989 BF305151 BG821966 BI089030 AW007738 BI222910 BM049422 BG028749 AI189162 AI831230 AW131497 BM272215 BE791105 AW778828 AA479594 AA480133 AA131997 AA284572 AA453009 BF928258 AA152127 AA393918 BF765307 BE247542 BF934697 BF341798 BE253409 AA470620 AI828932 AW379902 AV762678 AV741784 AV760892 AI025755 AA878562 AA630630 AA761708 AA862518 AA865831 AA862947 N53065 AA131821 AA293499 N23342 N26856 AI147346 AW951549 AA772963 BE245986 BG208493 AI831666 BG474873 BI023168 AU149647 BG197069 BG191102 BF304178 BE536135 AA706900 AA443583 AI002710 AW276192 AU149842 BG214797 BG198193 AW197923 AW627799 T98663 BG194788 BG214656 BF345258 BG716363 AI066528 BI546220 AA393815 AA132004 AA353826 H97858 BG187823 BF841463 AI351714 AV735966 BG196439 BG216840 BG198438 BG400762 427239 20459.2 AL532360 BE794750 AA582906 AI015067 AW271034 BG271636 AW075177 AW071374 AI345565 AI307208 BE138953 BE049086 AI334881
AW075006 AW075181 AA464019 AW302733 AW075100 AW073433 AI802854 AI334909 AI802853 AI345036 AI348921 AI340734 AI307478 AI251289 AW302327 AW072520 AI312145 AW073656 AW072513 AW071289 AI307559 AA876186 T29587 AI307493 AI255068 AI252868 AI252839 AW074809 AI252926 AI252160 AI251662 AI251262 AI610913 AI270787 AI270156 AI252075 AW073469 AW072901 AW072496 AW071420 AI305762 AI254764 AI802837 AI251264 AW073049 AW071311 AI340643 BE138965 BE138502 AW073456 AI334733 AI0543358E139260 AI054302 AI054060 AI054057 AI053722 AI289711 BE139228 AW470478 AW271039 AW302085 BE041872 AI254494 AI271496 AI252427 BF718773 BF718645 AW074866 BE857822 415819 40015.1 BE739429 BM460292 AL549095 BF752457 BE783002 BG035869 AW601528 AI880413 BF593762 AA974415 AW305318 AA716501 AI936239
AI809486 AI744171 AW804992 BF108747 AW804693 BE219333 AI807707 AA3069638G012140 BF741621 BF741618 BF741619 AW062543 AA155832 AU151381 AU158043 AU150410 AU145605 AU150252 AA188205 AU153035 AI147293 AA084507 AA868165 AI887120 AI468336 AW023112 H44035 F01513 AA747672 AW779630 AA757298 R77738 AU150931 R38473 AA189022 H96984 AL550490 AW949737 AU150194 AU149258 AI749453 AW172950 AW276160 AI753604 AI421762 AW575512 AI275633 AW516120 AI340167 AI567728 AI797326 AI471532 AI074080 AI633122 AW674646 AW316571 AA258187 AA102780 AA258186 AI363307 AA862862 AI206836 AA629555 AA486287 AI185097 AI872389 BE465687 AI246746 AI351453 AI189679 AA594582 AI038639 AA862764 AA644332 AA912423 AA601552 AW014502 AA694605 AW068949 BF941650 AW297886 BF941649 AI077854 AI027442 AA705602 AW020757 BI491734 AA977135 AA653973 BI522334 AA398723 AI280083 AI419671 AW009199 AA496011 AU144081 AI538440 BF741690 BF741680 H41990 AV724108 AW955578 BE698790T29312 BG954488 R33179 BI832621 BF742040 BE091493 H92122 BG614879 AW993709 AI216562 H44107 AA393530 BE173154 BG285054 BF751883 AA489308 BF741676 R64496 BE183198 H97097 AW062534 BF036430 AW192614 BF431707 N30258 AA629072 BG954496 AI401616 BG960957 400202 11771.2 BE873890 BF745945 AA156007 AA573157 AW874610 AA916387 N75963 BM083306 AW044671 BC013008 NM.002795 D26598 BG118716 BI910891
BF972860 BG1198428I094093 AL538757 BE271653 BI856538 BE909573 BG109826 BE784430 BE899255 BI833973 BM010809 BE621321 BG684956 BE904726 BI871370 AV708990 BF971483 BE298241 BI197007 BE272092 BG120374 AW963509 BE540572 AV744947 BG943041 AW327463 BG472870 BE393697 N28533 AA316042 N42043 AW404246 AW892094 AA379896 AW801110 AW406977 AA379791 BG941889 BE076254 AA360459 AA379385 AA320056 BG942618 D31230 AA308300 AA360371 AA371733 AA732937 AA494241 W32225 BF745937 AI383690 BG202360
TABLE 50C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al * refers to the publicadon endded "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposidon Indicates nudeodde positions of predicted exons
Pkey Ref Strand NLposidon
404854 7143420 Bus 14260-14537
405506 6466489 Plus 80014-80401,80593-81125
402474 7547175 Minus 5352553628,5575555920,57530-57757
400750 8119067 Plus 198991-199168,199315199548
TABLE 51 A ABOUT 453 GENES UPREGULATED IN PRIMARY MELANOMAS RELATIVE TO NORMAL SKIN
Table 51A lists about 453 genes upregulated in pπmary melanomas reladve to normal skin Genes were selxted from 59680 probesets on the Eos/Affymetox Hu03 Genxhip array Gene expression data for exh probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflxdng the relative level of mRNA expression Pkey Unique Eos probeset idendfier number
ExAxn Exemplar Axession number, Genbank axession number
UnigenelD Unigene number
Unigene Title Unigene gene dfle
R1 90th percendle of pπmary melanoma Als divided by 90th percendle of normal skin Als
R2 90th percendle of pnmary melanoma Als divided by 90th percendle of noπnal skin Als where the 15th percendle of normal dssue Als was subtrxted from both the numerator and denominator
Pkey ExAxn UnigenelD Unigene Title R1 R2
452838 U65011 Hs 30743 preferentially expressed andgen in mela 1406 1556
430377 NM 001922 Hs 301865 dopxhrome tautomerase (dopxhrome delta 1364 11 62
426555 NM 000372 Hs 2053 tyrosinase (xulxutaneous albinism IA) 1350 798
438549 BE386801 Hs 21858 tπnucleodde repeat containing 3 1278 1380
422424 AI186431 Hs 296638 prostate differentiation fxtor 11 88 1556
426600 NM 003378 Hs 171014 VGF nerve growth fxtor inducible 10 14 2246
430822 AJ005371 Hs 248017 glyceraldehyde-3-phosphate dehydrogenase 9 33 7 25
457211 AW972565 Hs 32399 ESTs, Weakly simila to S51797 vasodilat 866 962
438380 T06430 Hs 6194 chondroidn sulfate proteoglycan BEHAB/b 787 9 58
417355 D13168 Hs 82002 endothelin rxeptor type B 766 463
447210 AF035269 Hs 17752 phosphaddylsenne-spxific phospholipas 738 904
413554 AA319146 Hs 75426 sxretogranm II (chromogranin C) 664 732
415752 BE314524 Hs 78776 putadve transmembrane protein 646 465
421508 NM 004833 Hs 105115 absent in melanoma 2 644 7 00
449644 AW960707 Hs 148324 ESTs 643 592
426312 AF026939 Hs 181874 interferon-induced protein with tetratπ 6 27 647
446921 AB012113 Hs 16530 small inducible cytokine subfamily A (Cy 6 17 370
429500 X78565 Hs 289114 hexabrxhion (tenascin C, cytotxtin) 609 392
414812 X72755 Hs 77367 monokme induced by gamma interferon 604 7 73
452973 H88409 Hs 40527 ESTs 604 589
402075 ENSP00000251056* Plasma membrane calcium 596 250
436856 AI469355 Hs 127310 ESTs 572 529
425088 AA663372 Hs 169395 hypothetical protein FU12015 568 588
439310 AF086120 Hs 102793 ESTs 562 630
429170 NM 001394 Hs 2359 dual specificity phosphatase 4 562 330
413670 AB000115 Hs 75470 hypothedcal protein, expressed in osteo 550 428
409512 AW979187 Hs 293591 melanoma differentiation assxiated prot 536 4 14
430540 AW245422 Homo sapiens cDNA FU22105 fis, clone H 536 464
436315 BE390513 Hs 27935 hypothetical protein MGC4837 535 431
442426 AI373062 Hs 332938 hypothetical protein MGC5370 528 403
435056 AW023337 Hs 5422 glycoprotein M6B 523 325
432828 AB042326 Hs 287402 chondroidn 4-sulfotransferase 520 552
430294 AI538226 Hs 32976 guanine nucleotide binding protein 4 5 14 482
431639 AK000680 Hs 266175 phosphoprotein associated with GEMs 509 435
430838 N46664 Hs 169395 hypothedcal protein FU12015 506 368
414004 AA737033 Hs 7155 ESTs, Moderately similar to 2115357A TYK 504 423
407366 AF026942 Hs 17518 gb Homo sapiens cιg33 mRNA, partial sequ 494 629
422192 AA305159 Hs 113019 fls485 488 562
420208 BE276055 Hs 95972 silver (mouse homolog) like 488 600
446006 NM 004403 Hs 13530 deafness, autosomal dominant 5 477 433
440065 W03476 Hs 266331 hypothedcal protein MGC4595 474 985
421574 AJ000152 Hs 105924 defensin, beta 2 474 575
440274 R24595 Hs 7122 scrapie responsive protein 1 472 278
417166 AA431323 Hs 42146 ESTs 468 4 29
415314 N88802 Hs 5422 gly∞protein M6B 4 65 373
443983 H04482 Hs 163724 ESTs 464 306 432642 BE297635 Hs 3069 heat shxk 70kD protein 9B (mortalιn-2) 462 287
437179 AA393508 serologically defined colon cancer andg 462 508
417933 X02308 Hs 82962 thymidylate synthetase 458 302
431620 AA126109 Hs 264981 2-5'-olιgoadenylate synthetase 2 (69-71 450 4 37
431629 AU077025 Hs 265827 interferon alpha-mducible protein (do 449 16 82
447937 AL109716 Hs 20034 Homo sapiens mRNA full length insert cDN 444 595
409264 NM 014937 Hs 52463 KIAA0966 protein 4 42 294
434203 BE262677 Hs 283558 hypothedcal protein PR01855 442 354
422309 U79745 Hs 114924 solute earner family 16 (monxarboxylic 438 330
449722 BE280 74 Hs 23960 cyclm B1 432 407
446619 AU076643 Hs 313 sxreted phosphoprotein 1 (osteopondn, 4 30 382
450065 AL050107 Hs 24341 tranxπpdonal co-xdvator with PDZ-bi 428 436
424247 X14008 Hs 234734 lysozyme (renal amyloidosis) 427 305
413916 N49813 Hs 75615 apolipoprotein C-ll 4 25 468
420267 N37030 Hs 173337 ESTs 4 24 424
442739 NM 007274 Hs 8679 cytosolic xyl coenzyme A thioester hydr 4 21 300
433576 BE080715 Hs 161091 ESTs 420 631
412652 AI801777 ESTs 420 273
438209 AL120659 Hs 6111 aiyl-hydrocarbon receptor nuclea fransl 4 20 5 18
441553 AA281219 Hs 121296 ESTs 4 14 494
407856 AA045281 Hs 266175 phosphoprotein assxiated with GEMs 4 14 3 14
439926 AW014875 Hs 137007 ESTs 412 476
429903 AL134197 Hs 93597 cyclm-dependent kinase 5, regulatory su 4 12 485
400860 Target Exon 4 10 520
409415 AA579258 Hs 6083 Homo sapiens cDNA FU21028 fis, clone C 408 602
416636 N32536 Hs 42645 solute earner family 16 (monxarboxylic 408 242
452826 BE245286 Hs 301636 peroxisomal biogenesis fxtor 6 406 296
407748 AL079409 Hs 38176 KIAA0606 protein, SCN Orcadian Oscillat 406 228
417632 R20855 Hs 5422 glycoprotein M6B 401 296
418064 BE387287 Hs 83384 S100 calcium-binding protein, beta (neur 400 462
448111 AA053486 Hs 20315 interferon-induced protein with tetratπ 400 282
420674 NM 000055 Hs 1327 butyrγlcholmesterase 400 290
451668 Z43948 Hs 326444 cartilage acidic protein 1 399 5 17
430015 AW768399 ESTs 396 389
407756 AA116021 Hs 38260 ubiquitin spxific protease 18 394 291
430223 NM 002514 Hs 235935 nephroblastoma overexpressed gene 393 389
433364 AI075407 Hs 296083 ESTs, Moderately similar to I54374 gene 393 470
448719 AA033627 Hs 21858 tπnucteodde repeat containing 3 392 7 78
419381 AB023420 Hs 90093 heat shxk 70kD protein 4 387 334
402609 KIAA1209 protein 387 369
408083 BE383668 Hs 42484 hypothedcal protein FU10618 386 404
409703 NM 006187 Hs 56009 2-5'-olιgoadenylate synthetase 3 (100 k 385 364
420218 AW958037 πbosomal protein L4 384 320
434826 AF155661 Hs 22265 pyruvate dehydrogenase phosphatase 384 5 19
410600 AW575742 ESTs, Moderately similar to S65657 alpha 3 82 574
442117 AW664964 Hs 128899 ESTs, hypothetical protein for IMAGE 447 382 296
428513 BE220806 Hs 184697 Homo sapiens clone 23785 mRNA sequence 382 403
417381 AF164142 Hs 82042 solute earner family 23 (nucleobase tra 380 356
432094 AI658580 Hs 61426 Homo sapiens mesenchymal stem cell prote 379 323
443105 X96753 Hs 9004 chondroidn sulfate proteoglycan 4 (mela 377 366
423605 AF047826 Hs 129887 cadheπn 19, type 2 3 72 228
407846 AA426202 Hs 40403 Cbp/p300-ιπterxtιng transxdvator wit 3 72 534
442578 AK001643 Hs 8395 hypothedcal protein FU10781 371 342
448966 AW372914 Hs 86149 phosphoinositol 3-phosphate-bιndιng prot 368 3 31
428227 AA321649 Hs 2248 small inducible cytokine subfamily B (Cy 368 424
400750 Target Exon 368 274
447217 BE465754 Hs 17778 neuropilin 2 366 360
459373 BE408266 Hs 301406 hypothedcal protein PP3501 366 348
419628 H67546 Hs 49768 ESTs 362 4 13
406868 AA505445 Hs 300697 immunoglobulin heavy constant gamma 3 (G 361 440
421866 M24470 Hs 1435 guanosine monophosphate reductase 359 3 53
421709 AA159394 Hs 107056 CED-6 protein 3 57 263
438501 Z44110 Hs 86149 phosphoinositol 3-phosphate-bιndιng prot 356 354
408962 8E386436 Hs 44317 SRY (sex determining region Y)-box 10 355 270
425139 AW630488 Hs 25338 protease, senne, 23 350 280
428411 AW291464 Hs 10338 ESTs 349 258
452744 AI267652 Hs 246107 Homo sapiens mRNA, cDNA DKFZp434E082 (fr 348 461
411305 BE241596 Hs 69547 myelin basic protein 348 337
447343 AA256641 Hs 236894 ESTs, Highly similar to S02392 alpha-2-m 347 268
429954 AI918130 Hs 21374 ESTs 347 263
417621 AV654694 Hs 82316 interferon-induced, hepa ds C-assxiat 346 234
435256 AF193766 Hs 13872 cytokine-like protein C17 346 247
450534 AI570189 Hs 25132 KIAA0470 gene product 342 365
421100 AW351839 Hs 124660 Homo sapiens cDNA FU21763 fis, ctone C 341 263
418506 AA084248 Hs 85339 G protein-coupled rxeptor 39 340 4 02
442711 AF151073 Hs 8645 hypothedcal protein 339 295
453344 BE349075 Hs 44571 ESTs 338 2 38
436700 AI693690 Hs 301406 hypothedcal protem PP3501 336 460
418007 M13509 Hs 83169 matπx metalloproteinase 1 (interstitial 3 36 261
433867 AK000596 Hs 3618 hippxalc -like 1 336 426
408393 AW015318 Hs 23165 ESTs 336 2 10
447484 AA464839 Hs 292566 hypothetical protem FU 14697 336 249
412828 AL133396 Hs 74621 pπoπ protein (p27-30) (Creutzfeld-Jakob 335 2 27 426158 NM 001982 Hs 199067 v-erb-b2 avian erythroblastic leukemia v 335 258
440325 NM 003812 Hs 7164 a dismtegnn and metalloproteinase doma 334 255
420602 AF060877 Hs 99236 regulator of G-protem signalling 20 334 596
439963 AW247529 Hs 6793 platelet-activating fxtor xetylhydrola 334 273
406663 U24683 immunoglobulin heavy constant mu 331 521
427540 R12014 Hs 20976 ESTs 330 340
412141 AI183838 Hs 48938 hypothedcal protein FLJ 21802 329 280
400282 NM.O05313 Homo sapiens glu∞se regulated 329 346
419870 AW403911 Hs 266175 phosphoprotein assxiated with GEMs 3 28 520
416539 Y07909 Hs 79368 epithelial membrane protein 1 328 279
431518 AA743462 Hs 165337 ESTs 327 251
402994 NM.002463* Homo sapiens myxovirus (inftu 326 638
419956 AL137939 Hs 40096 cadhenn 19, type 2 326 448
421379 Y15221 Hs 103982 small inducible cytokine subfamily B (Cy 326 371
444371 BE540274 Hs 239 forkhead box M1 325 372
432874 W94322 Hs 279651 melanoma inhibitory xdvity 325 533
417282 AA195203 RAB5C, member RAS oncogene family 3 24 320
439569 AW602166 Hs 222399 CEGP1 protein 3 24 232
422530 AW972300 Hs 118110 bone marrow stromal cell andgen 2 324 620
403817 NM.015271 Homo sapiens bipartite modf- 323 370
407857 AI928445 Hs 92254 synaptotagmm-like 2 322 249
426334 BE305081 Hs 169358 hypothedcal protein 321 246
453837 AL138387 Hs 256126 bxuloviral IAP repeat-containing 7 (liv 319 550
427283 AL119796 Hs 174185 xtonuclxdde pyrophosphatase/phosphodi 3 18 204
437379 AL359575 Hs 23765 Homo sapiens mRNA, cDNA DKFZp547M123 (fr 3 18 373
424090 X99699 Hs 139262 XIAP assxiated fxtor-1 318 444
410491 AA465131 Hs 64001 Homo sapiens clone 25218 mRNA sequence 3 18 326
408418 AW963897 Hs 44743 KIAA1435 protein 3 16 221
412326 R07566 Hs 73817 small inducible cytokine A3 (homologous 3 16 404
402829 C1002500 gι|6754254|reflNP_034610 1| hea 3 15 457
437862 AW978107 Hs 5884 Homo sapiens mRNA, cDNA DKFZp586C0224 (f 3 15 307
425935 Z98200 Hs 163724 HSPC019 protein 3 14 308
417124 BE122762 Hs 25338 ESTs 3 14 273
425071 NM.013989 Hs 154424 deiod ase, lodothyronme, type II 3 11 216
412490 AW803564 Hs 288850 Homo sapiens cDNA FU22528 fis, clone H 3 10 243
442271 AF000652 Hs 8180 syndxaπ binding protein (synteπm) 3 10 283
415817 U88967 Hs 78867 protein tyrosine phosphatase, rxeptor-t 3 10 1 78
429083 Y09397 Hs 227817 BCL2-related protein A1 3 10 317
437673 AW665665 Hs 153034 ESTs 3 10 332
407813 AL120247 Hs 40109 KIAA0872 protein 3 10 390
445745 AB007924 Hs 13245 KIAA0455 gene product 3 10 335
451537 R56631 Hs 26550 retinoid X rxeptor, gamma 309 445
408654 BE018882 Hs 46721 UCC1 protein 308 365
444484 AK002126 Hs 11260 hypothetical protein FU 11264 308 212
446019 AI362520 histone dexetylase 3 308 226
434276 AF123659 Hs 93605 leucine zipper, putative tumor suppresso 308 529
427871 AW992405 Hs 59622 Homo sapiens, clone IMAGE 3507281, mRNA, 306 336
403532 NM.024638 Homo sapiens hypothedcal prot 306 337
433160 AW207002 Hs 134342 TASP for tesds-spxific adπamycin sens 304 3 17
446341 AL040763 Hs 310735 ESTs Moderately similar to ALU7 HUMAN A 303 298
426501 AW043782 Hs 293616 ESTs 303 201
450325 AI935962 Hs 91973 ESTs 302 2 19
418941 AA452970 Hs 239527 E1B-55kDa-assxιated protein 5 302 3 29
431797 BE169641 Hs 270134 hypothetical protein FLJ20280 302 254
442064 AI422867 Hs 88594 ESTs 300 1 96
405451 dihydropyπmidinase-like 3 300 298
414915 NM 002462 Hs 76391 myxoviπis (influenza) resistance 1 , homo 299 641
454117 BE410100 Hs 40368 adaptor-related protein complex 1, Sigma 298 325
452958 AA883929 Hs 40527 ESTs 298 4 14
427647 W19744 Hs 180059 Homo sapiens cDNA FU20653 fis, clone KA 296 330
409190 AU076536 Hs 50984 sarcoma amplified sequence 296 247
428819 AL135623 Hs 193914 KIAA0575 gene product 296 4 16
428450 NM.014791 Hs 184339 KIAA0175 gene product 296 241
414219 W20010 Hs 75823 ALL1 fused gene from chromosome 1q 295 279
411358 R47479 Hs 94761 KIAA1691 protein 2 95 470
432467 T03667 Hs 239388 Human DNA sequence from clone RP1-304B14 294 265
400222 NM.002082* Homo sapiens G protein-couple 294 269
405785 NM.025184* Homo sapiens hypothetical pro 294 255
409760 AA302840 gb EST10534 Adipose dssue, white I Homo 294 257
418113 AI272141 Hs 83484 SRY (sex determining region Y)-box 4 293 252
409038 T97490 Hs 50002 small inducible cytokine subfamily A (Cy 293 243
456760 AW961251 Hs 127828 guanine nudeodde binding protein (G pr 292 320
459710 AI701596 Hs 121592 ESTs 291 445
411395 AA889673 Hs 7542 KIAA1802 protein 290 272
427528 AU077143 Hs 179565 minichromosome maintenance deficient (S 290 2 27
406964 M21305 FGENES predicted novel sxreted protein 290 203
428834 AW899713 Hs 339315 ESTs 289 355
413190 AA151802 Hs 40368 adaptor-related protein complex 1 , sigma 289 387
438619 AB032773 TU12B1-TY protein 288 237
442432 BE093589 Hs 38178 hypothetical protein FU 23468 287 200
428782 X12830 Hs 193400 interieukin 6 receptor 286 251
454027 R40192 Hs 21527 Human DNA sequence from clone GS1-115M3 286 307
453107 NM 016113 Hs 279746 vanilloid receptor-like protein 1 286 558 414737 AI160386 Hs 125087 ESTs 284 279
412140 AA219691 Hs 73625 RAB6 interxting kinesm-like (rabkmes 284 380
447735 AA775268 Hs 6127 Homo sapiens cDNA FU23020 fis, clone L 283 2 11
416091 AF295370 Hs 283082 defensin beta 3 283 332
442445 AA082665 Hs 209561 KIAA1715 protem 281 2 17
408208 BE018717 ESTs 281 243
430066 AI929659 Hs 237825 signal recogmdon particle 72kD 280 225
424755 AB033094 Hs 152925 KIAA1268 protem 280 274
422616 BE300330 Hs 118725 selenophosphate synthetase 2 279 201
405506 Target Exon 278 265
411619 AI418609 Hs 71040 hypothetical protein FLJ20425 278 310
400236 Eos Control 278 221
452698 NM 001295 Hs 301921 chemokine (C-C modf) rxeptor 1 278 3 15
446488 AB037782 Hs 15119 KIAA1361 protein 278 280
439778 AL109729 Hs 99364 putadve transmembrane protein 278 378
420005 AW271106 Hs 133294 ESTs 278 286
428642 NM 014899 Hs 10432 KIAA0878 protein 277 307
453779 N35187 Hs 43388 28kD interferon responsive protein 276 456
425289 AW139342 Hs 155530 interferon, gamma-inducible protein 16 276 1 83
437723 AI672731 Hs 13256 ESTs 2 76 423
416730 T99937 gb ye72d04 r1 Soaes fetal liver spleen 276 298
426153 AF057169 Hs 182771 vitelliform mxular dystrophy (Best dise 276 321
444670 H58373 Hs 332938 hypothedcal protein MGC5370 276 397
421351 AU076667 Hs 103755 receptor-interxdng seπne-threonine ki 274 350
406673 M34996 Hs 198253 major histocompatibility complex, class 274 324
427268 X78520 Hs 174139 chlonde channel 3 274 282
428403 AI393048 Hs 326159 leucine nch repeat (in FLU) interxtin 274 1 95
409417 AA156247 Hs 104879 senne (or cysteine) proteinase inhibito 274 299
419705 AW368634 Hs 154331 ESTs 274 228
440457 BE387593 Hs 21321 Homo sapiens clone FLB9213 PR02474 mRNA, 272 360
413599 AJ006239 Hs 75438 qumoid dihydropteπdme reductase 272 243
447164 AF026941 Hs 17518 vipiπn, similar to inflammatory respoπ 2 72 477
430594 AK000790 Hs 246885 hypothedcal protein FU20783 272 367
413278 BE563085 Hs 833 interferon-sdmulated protein 15 kDa 271 1206
424572 M19650 Hs 179600 2,3'-cyclιc nudeodde 3' phosphodieste 2 70 240
409142 AL136877 Hs 50758 SMC4 (structural maintenance of chromoso 270 381
425996 W67330 hypothedcal protein AL110115 269 385
430441 BE398091 desmoplakiπ (DPI, DPII) 268 255
442355 AA456539 Hs 8262 lysosomal-assxiated membrane protein 2 268 1 67
421362 AK000050 Hs 103853 hypothedcal protein FU20043 268 294
437158 AW090198 KIAA1150 protein 268 1 89
412315 AW936678 gb PM2 DT0023-080300-004-a04 DT0023 Homo 268 280
432878 BE386490 Hs 279663 Pinn 268 258
408822 AW500715 Hs 57079 Homo sapiens cDNA FLJ13267 fis, clone OV 268 274
426759 AI590401 Hs 21213 ESTs 268 2 35
405486 Target Exon 267 270
410326 AI368909 Hs 47650 ESTs 267 333
434040 AW444613 Hs 288809 hypothetical protein FU20159 266 254
437396 BE140396 Hs 21621 hypothedcal protein DKFZp762O076 266 1 91
412719 AW016610 Hs 816 ESTs 266 421
451708 AI306536 Hs 60975 ESTs 266 569
418299 AA279530 Hs 83968 integnn beta 2 (andgen CD18 (p95), ly 266 231
425017 AL119305 Hs 26409 ESTs 266 273
400235 NM.005336 Homo sapiens high density lipo 266 229
444809 BE207568 Hs 208219 oculospanin 264 286
436291 BE568452 Hs 344037 protein regulator of cytokinesis 1 264 233
406382 C16001275* gι|12698037|dbj|BA821837 1| ( 264 248
432241 AI937060 Hs 6298 KIAA1151 protein 263 316
417308 H60720 Hs 81892 KIAA0101 gene product 263 2 10
429294 AA095971 Hs 198793 Homo sapiens cDNA FU22463 fis, clone H 262 243
453935 AI633770 Hs 42572 ESTs 262 1 99
401454 NM.014226* Homo sapiens renal tumor and 262 301
435456 AW292677 Hs 248122 G protein-coupled rxeptor 24 262 594
418478 U38945 Hs 1174 cyclin-dependent kinase inhibitor 2A (me 261 302
453256 Al 565587 Hs 32556 KIAA0379 protein 260 268
451622 AW139587 Hs 30579 Homo sapiens cDNA FU23070 fis, clone L 260 251
424006 AF054815 Hs 137548 CD84 andgen (leukxyte antigen) 260 256
409354 N68188 Hs 159472 Homo sapiens cDNA FU22224 fis, clone H 259 300
425392 N39725 Hs 15220 zinc finger protein 106 258 352
427286 AW732802 Hs 2132 epidermal growth fxtor rxeptor pathway 258 1 86
418166 AI754416 Cdc42 effector protein 3 258 215
413794 AF234532 Hs 61638 myosin X 258 254
445707 AI248720 Hs 114390 ESTs 258 1 95
416640 BE262478 Hs 79404 neuron-spxific protein 257 246
427982 NM 016156 Hs 181326 KIAA1073 protein 256 1 74
439453 BE264974 Hs 6566 thyroid hormone rxeptor interxtor 13 256 2 22
455839 BE145814 gb MR0-HT0205101299-202-a04 HT0208 Homo 255 234
447737 AK000643 Hs 19404 DKFZP564L0862 protein 2 55 231
423799 AW026300 Hs 132906 19A24 protein 254 211
442762 AF035119 Hs 8700 deleted in liver cancer 1 254 247
432886 BE159028 Hs 279704 chromatin a∞essibility ∞mplex 1 254 399
440676 NM 004987 Hs 112378 LIM and senescent cell andgen-like doma 254 296
424481 R19453 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbx 253 698 422340 AW296219 Hs 115325 RAB7 member RAS oncogene family-like 1 253 306
428844 AW972635 Hs 301904 hypothedcal protein FLJ 12671 253 3 13
458997 AW937420 ESTs 253 1 63
419591 AF090900 Hs 91393 Homo sapiens cDNA FU21887 fis clone H 252 230
414807 AI738616 Hs 77348 hydroxyprostaglandin dehydrogenase 1 (N 252 1 80
429238 NM.002849 Hs 198288 protein tyrosine phosphatase, rxeptor t 252 302
432882 NM 013257 Hs 279696 semm/glucocorticoid regulated k ase-li 252 305
407260 L09095 gb Homo sapiens mRNA fragmenl 250 500
431186 NM 012249 Hs 250697 ras-dke protein 249 616
417542 J04129 Hs 82269 progestagen-assxtated endometnal prote 249 471
419556 U29615 Hs 91093 chidnase 1 (chitotπosidase) 248 577
408209 NM.004454 Hs 43697 ets vanant gene 5 (ets-related molxule 248 377
405885 Target Exon 246 311
406837 R70292 Hs 156110 immunoglobulin kappa constant 244 3 10
412609 Z48804 Hs 74124 xula albinism 1 (Nettleship-Falls) 244 490
421633 AF121860 Hs 106260 sorting nexin 10 244 431
415929 AA724373 Hs 49344 hypothedcal protein FU11006 242 319
413171 AA318325 Hs 75219 tyrosinase-related protein 1 237 357
406621 X57809 Hs 8997 immunoglobulin lambda Ixus 236 587
414142 AW368397 Hs 334485 hemicendn (fibulin 6) 236 304
410700 AA352335 Hs 65641 hypothedcal protein FU20073 236 366
414283 AW960011 Hs 154993 ESTs 234 495
453931 AL121278 Hs 25144 ESTs 234 4 18
422515 AW500470 Hs 117950 multifunctional polypepdde simila to S 232 345
435292 N20514 Hs 172965 ESTs 232 494
412926 AI879076 Hs 75061 xrophage mynstoylated alanine-πch C 231 378
440197 AW340708 Hs 317714 pallid (mouse) homolog, pallidm 230 395
425262 D87119 Hs 155418 GS3955 protein 229 508
439979 AW600291 Hs 6823 hypothedcal protem FU 10430 228 405
403969 ENSPOO000034663 Zinc finger protein 131 228 364
421686 AB011156 Hs 106794 KIAA0584 protein 226 331
432800 BE391046 Hs 278962 AIM-1 protein 224 408
406782 AA430373 gb zw20f11 s1 Soares ovary tumor NbHOT H 2 24 347
415539 AI733881 Hs 72472 BMP-R1B 222 366
447523 BE613328 Hs 21938 hypothetical protein FU12492 220 343
433180 AB038651 Hs 31854 K562 cell-denved leucine-zipper-like pr 2 20 3 52
415825 Y18024 Hs 78877 inositol 1,4,5tπsphosphate 3-kιnase B 219 376
407241 M34516 gb Human omega light chain protein 14 1 2 18 3 17
422243 AW803733 Hs 23585 hypothedcal protein MGC12250 2 18 3 28
417324 AW265494 ESTs 216 585
412819 T25829 Hs 24048 FK506 binding protein precursor 214 349
432342 AL036128 Hs 274404 plasminogen xdvator, tissue 2 13 4 39
427923 AW274357 Hs 301406 hypothedcal protein PP3501 213 548
417437 U52682 Hs 82132 interferon regulatory fxtor 4 2 13 308
425535 AB007937 Hs 158287 KIAA0468 gene product 2 13 866
429638 AI916662 Hs 211577 kmxdn 1 (kinesin rxeptor) 212 301
409154 U72882 Hs 50842 interferon-induced protein 35 2 12 466
429951 AL040521 Hs 15220 zinc finger protein 106 2 12 371
418918 X07871 Hs 89476 CD2 andgen (p50), sheep red blood cell 2 11 4 27
419200 AW966405 EST 2 11 358
416448 L13210 Hs 79339 Ixdn, galxtoside-binding soluble, 3 2 10 534
425069 AA687465 Hs 298184 potassium voltage-gated channel, shaker- 207 786
445133 AW157646 Hs 198689 ESTs 206 368
411492 T46848 Hs 70337 immunoglobulin superfamily, member 4 204 336
408015 AW136771 Hs 244349 epidermal differentiadon complex protei 203 341
424412 H15512 Hs 10043 hypothedcal protein FU13074 203 382
431657 AI345227 Hs 105448 ESTs, Weakly similar to B34087 hypothed 202 303
427536 BE277141 Hs 115803 gb 601178666F1 NIH.MGC.20 Homo sapiens c 202 309
400533 ENSP00000209376* PRED65 protem (Fragmen 200 329
432680 T47364 Hs 278613 interferon, alpha-inducible protein 27 1 99 307
410129 BE244074 Hs 58831 regulator of Fas-induced apoptosis 1 97 452
417312 AW888411 Hs 250811 leukemia-assxiated phosphoprotein p18 ( 1 97 3 26
423952 AW877787 Hs 136102 KIAA0853 protein 1 94 379
455705 AW161061 ESTs, Weakly similar to zinc linger prot 1 93 316
419723 AL120193 Hs 339810 longevity assurance (LAG1 , S cerevisiae 1 93 311
438866 U44385 Hs 325495 dssue inhibitor of metalloproteinase 2 1 93 347
448410 AK000227 Hs 21126 hypothedcal protein FU20220 1 92 300
400292 AA250737 Hs 72472 BMP-R1B 1 92 407
436797 AA731491 Hs 334477 hypothetical protein MGC14879 1 90 304
406851 AA609784 major histocompatibility complex, class 1 90 653
428437 AV656017 Hs 184325 CGI-76 protein 1 89 339
431836 AF178532 Hs 271411 beta-site APP-cleaving enzyme 2 1 89 404
424687 J05070 Hs 151738 matπx metalloproteinase 9 (geladnase B 1 87 364
426322 J05068 Hs 2012 franscobaamm 1 (vitamin 812 binding pr 1 85 421
425221 AV649864 Hs 155188 TATA box binding protein (TBP)-assxιate 1 85 3 13
420162 BE378432 Hs 95577 cyclin-dependent kinase 4 1 85 304
443530 BE563088 Hs 9552 binder of Ari Two 1 85 3 20
433671 AW138797 Hs 132906 19A24 protein 1 84 339
424415 NM.001975 Hs 146580 enolase 2, (gamma, neuronal) 1 82 322
400991 Target Exon 1 82 4 11
418677 S83308 Hs 87224 SRY (sex determining region Y)-box 5 1 82 343
424441 X14850 Hs 147097 H2A histone family, member X 1 81 312
424825 AF207069 Hs 153357 prxollagen-lysme, 2-oxoglutaate 5-dιo 1 79 531 425818 AB021225 Hs 159581 matπx metalloproteinase 17 (membrane-in 1 79 340
416426 AA180256 Hs 210473 Homo sapiens cDNA FU14872 fis, clone PL 1 78 338
414945 BE076358 Hs 77667 lymphxyte andgen 6 complex, Ixus E 1 77 369
440942 AW246547 Hs 17901 Homo sapiens, clone IMAGE 3937015, mRNA, 1 77 3 12
401591 Target Exon 1 75 430
425923 NM 005026 Hs 162808 phosphoιnosιtιde-3-kιnase, catalydc, de 1 5 368
412844 A.828045 Hs 18016 Homo sapiens mRNA cONA OKFZp586H0324 (f 1 74 353
417237 H86385 Hs 81737 patmitoyl-protein thioesterase 2 1 73 306
419849 BE041436 Hs 93379 eukaryotic transladon imdadon fxtor 1 72 438
454429 BE273437 Hs 301406 hypothedcal protein PP3501 1 72 438
440672 AF083811 Hs 7345 MAD1 (mitodc arrest deficient, yeast, h 1 72 361
408204 AA454501 Hs 43666 protein tyrosine phosphatase type IVA, m 1 72 306
430148 BE387620 Hs 234489 Ixtate dehydrogenase B 1 71 438
426502 Y07759 Hs 170157 myosin VA (heavy polypepdde 12, myoxin) 1 70 3 13
413317 U53225 Hs 75283 sorting nexin 1 1 70 308
417333 AL157545 Hs 173179 bromodomam and PHD finger contanmg, 3 1 68 315
407223 H96850 gb yw03b12 s1 Soaes melanocyte 2NbHM Ho 1 68 419
413566 AW604451 Hs 285814 sprouty (Drosophila) homolog 4 1 67 574
404067 Target Exon 1 67 473
447630 AI660149 Hs 44865 lymphoid enhancer-binding fxtor 1 1 66 322
443337 Y07604 Hs 9235 non-metastadc cells 4, protein expresse 1 65 317
427747 AW411425 Hs 180655 seπne/threonine kinase 12 1 64 335
437912 BE278594 Hs 5912 F-box only protein 7 1 64 324
404140 NM.006510 Homo sapiens ret finger protei 1 64 310
414214 D49958 Hs 75819 glycoprotein M6A 1 64 345
427239 BE270447 ubiquitin earner protein 1 62 3 58
427289 AI097346 phosphoseπne aminotransferase 1 62 589
452923 BE276018 Hs 288940 five-span transmembrane protein M83 1 62 3 23
426020 AL110195 Hs 166017 microphthalmia-assoctated transcnpdon 1 62 400
439627 BE621702 Hs 29076 hypothedcal protein FU21841 1 61 500
451489 NM 005503 Hs 26468 amyloid beta (A4) precursor protein-bind 1 60 306
414699 AI815523 Hs 76930 synuclem, alpha (non A4 component of am 1 58 334
411825 AK000334 hypothedcal protein FU20327 1 56 3 18
438552 AJ245820 Hs 6314 type I transmembrane rxeptor (seizure-r 1 56 323
428081 AA421048 Hs 95011 syntrophm, beta 1 (dystrophin-assxiate 1 55 310
401914 Target Exon 1 54 333
424902 NM 003866 Hs 153687 inositol polyphosphate-4-phosphatase, ty 1 54 315
441648 H05734 Hs 30559 ESTs 1 52 336
439769 AA448828 Hs 30596 Homo sapiens mRNA full length insert cDN 1 52 3 17
437696 Z83844 HS 5790 hypothedcal protein dJ37E165 1 52 493
413019 BE281604 Hs 75140 low density lipoprotein-related protein- 1 52 301
419741 NM 007019 Hs 93002 ubiquidn earner protein E2-C 1 52 383
422596 AF063611 Hs 118633 2-5'-olιgoadenylate synthetase-like 1 50 304
421851 R18686 Hs 108896 lambda-crystallin 1 47 3 10
448499 BE613280 Hs 77550 hypothedcal protein MGC1780 1 44 307
427378 BE515037 Hs 177556 melanoma andgen, family D, 1 1 44 300
412641 M16660 Hs 74335 heat shxk 90kD protein 1 , beta 1 42 366
448143 AF039704 Hs 20478 ceroid-lipofuxinosis, neuronal 2, late 1 42 416
413291 NM.006278 Hs 75268 sialyltransferase 4C (beta-galxtosidase 1 41 330
435968 AW161481 Hs 111577 integral membrane protein 3 1 1 330
422486 BE514492 Hs 117487 gene near HD on 4p163 with homology to 1 40 301
443759 BE390832 Hs 134729 FXYO domain-∞ntain g ion transport reg 1 39 382
444441 AW613841 Hs 301394 hypothedcal protem MGC3101 1 39 343
430205 AB025904 Hs 235168 carbonic anhydrase XIV 1 36 332
406827 AA971409 gb op92c04 s1 NCI_CGAP_Lu5 Homo sapiens 1 35 303
406906 Z25424 gb H sapiens protein-seπne/threonine ki 1 34 6 25
426890 AA393167 Hs 41294 ESTs 1 34 366
433320 D60647 Hs 250879 ESTs, Highly similar to CTXN RAT CORTEXI 1 34 3 18
450358 AB010098 Hs 24907 coronin, xdn-bmdmg protein, 2B 1 33 319
421612 AF161254 Hs 106196 8D6 andgen 1 33 303
438915 AA280174 Hs 285681 Williams-Beuren syndrome chromosome regi 1 32 368
428342 AI739168 Homo sapiens cDNA FU13458 fis, clone PL 1 32 310
449444 AW818436 solute caπer family 16 (monxarboxylic 1 30 330
404700 Target Exon 1 30 314
403043 Target Exon 1 30 422
409858 NM 006586 Hs 56828 tonucleodde repeat containing 5 1 29 309
424679 AL117477 Hs 119960 DKFZP727G051 protein 1 27 313
406908 Z25437 gb H sapiens protein-tyrosme kinase gen 1 27 366
432665 AW603880 ATPase, H transporting, lysosomal (vxuo 1 26 309
423130 AW897586 Hs 21213 ESTs 1 24 334
453220 AB033089 Hs 32452 Homo sapiens mRNA for KIAA1263 protein, 1 24 315
442680 BE270707 Hs 8583 similar to APOBEC1 1 22 394
422319 AW403342 Hs 115232 splicing fxtor 3a, subunit 2, 66kD 1 21 336
402408 NM.030920* Homo sapiens hypothedcal pro 1 04 337
424905 NM.002497 Hs 153704 NIMA (never in mitosis gene a)-related k 1 00 302
TABLE 5 IB:
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank xcession numbers
Pkey CAT Number Accession 430540 713 2 BC017171 BC012195 NM 007126 AF100752 AL137377 Z70768 BM474865 BG754806 AU124376 BG757203 BG764420 BG775028 BG824418
BM045810 AU120387 BG770238 BG686740 BG913323 BI759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847
AI770171 BF196861 BE856897 AA463876 AI375927 AA648810 AA948193 AA490916 AI459893 AI458188 AI240408 AI191843 AI131029 AW768399
AI365196 AW337984 AW026150 BE466591 BE674599 AI818438 AA772197 AI651927 AW151143 BI198825 BG819083 BM458764 BE903567
BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542 AW246215 BE501897 BE903610
BE561530 BE560537 BE903782 BE732947 BI227204 BG761305 BE262642 BE391848 BE382475 BGO08258 BI547991 BI459099 BE391391 BE259420
BE298109 AW245422 AI423847 AI914618 H80534 BE301004 AL531791 AI435581 BF793112 AL577303 AA373265 BE746965 BF743630 BE879296
AI359493 BM018598 AI689260 AW072450 F20201 AW151405 AW517572 AA773468 BG259694 BE391163 BG621529 AI421728 BG767231 BM462953
BG340524 W52648 AA113434 BE785431 BI041981 BG832385 BG253168 BG759470 BF3693298F981332 BE259418 BE785738 BI091658 N72512
W58732 W85690 BG958989 AI205206 H19721 W17051 W77958 BI262010 AA844319 W74143 W72214 N85194 BE734033 BG164099 AA931069
F13645 R41394 AK025758 BG180977 BE349455 AA812018 AA740241 AI027722 AI150356 AA886395 AW977627 BE220225 AA884082 AW518114
AI243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 AI251109 R07704 AA765606 AA724593 AI918399 AI537550 AA491103
AW008188 R07703AA989120 AA746235 AW028983 AA789102 AU185751 AW971465 AA489681 AW971893 AW612086 BE077936 BI860809
BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591
437179 12239.1 AK055109 BC019085AA187684 BG656226 BM023227 AI932311 AW264381 AA398371 BM021483AI432433 AI375777 AI129580 AW262782
AA134107 BM023515 AA977504 AI859222 AI348454 R69725 AA975268 BM021207 AL080074 AA129218 AW207842 N90581 AA771919 AI092259
AI028416 AI074114 BG656536 BE501677 AW193419 AA917040 W90430 AI342984 AI378957 AL036486 AW020068 BI491093 BF476021 R41226
R69631 F04125 C02343 AA115589 R56480 AI400988 R54266 R31422
412652 18858.2 AI801777 BE677762 AW0O8210 AW009441 BE350994 BE207949 AI091475 AI802774 AI827533 AI075363 AI659979 AA687855 AI078125 AI090285
AA670058 AA602411 AA683472 AI436058 AA612826 AI038932 BG057726 AI167355 BF449023 AI289476 AW074381 BF972912 AI991780 AA889119
AI537472 Z39730 AI868953 AI192337 BE812978 BE812939 AA115248 H99006 AI915784 F08973 T16748 D20468 AA609899 BF081234 AA115336
BE812876 BE812972 BE812982 BE813006 BE813019 R43883 BE812981
430015 713.2 BC017171 BC012195 NM.007126 AF100752 AL137377 Z70768 BM474865 BG754806 AU124376 BG757203 BG764420 BG775028 BG824418
BM045810 AU120387 BG770238 BG686740 BG913323 BI759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847
AI770171 BF196861 BE856897 AA463876 AI375927 AA648810 AA948193 AA490916 AI459893 AI458188 AI240408 AI191843 AI131029 AW768399
AI365196 AW337984 AW026150 BE466591 BE674599 AI818438 AA772197 AI651927 AW151143 BI198825 BG819083 BM458764 BE903567
BE732715BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542 AW246215 BE5018978E903610
BE561530 BE560537 BE903782 BE732947 BI227204 BG761305 BE262642 BE391848 BE382475 BG008258 BI547991 BI459099 BE391391 BE259420
BE298109 AW245422 AI423847 AI914618 H80534 BE301004 AL531791 AI435581 BF793112 AL577303 AA373265 BE746965 BF743630 BE879296
AI359493 BM018598 AI689260AW072450 F20201 AW151405 AW517572 AA773468 BG259694 BE391163 BG621529AI421728 BG767231 BM462953
BG340524 W52648 AA113434 BE785431 BI041981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 BI091658 N72512
W58732 W85690 BG958989 AI205206 H19721 W17051 W77958 BI262010 AA844319 W74143 W72214 N85194 BE734033 BG164099 AA931069
F13645 R41394 AK025758 BG180977 BE349455 AA812018 AA740241 AI027722 Al 150356 AA886395 AW977627 BE220225 AA884082 AW518114
AI243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 AI251109 R07704 AA765606 AA724593 AI918399 AI537550 AA491103
AW008188 R07703 AA989120 AA746235 AW028983 AA789102 AU185751 AW971465 AA489681 AW971893 AW612086 BE077936 BI860809
BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591
420218 191547.1 AW958037 R42557 AI337047 AA948360 AI638005 AA459950 AI624915 AI638047 AI467856 AI521826 AA860305 AI932315 AW003092 AW271756
AW779380 AA609879 AI634791 AI493770 AI565211 Z41145 AI627952 AA303734 BE349457 AW196765 AA256527 BE089727
410600 497855.1 BF347859 AW499616 AA191322 AW499617 AL601010 AW575742 AA729043 BE463447 AA086179 BE549623 AI335824 AW408712 BM149172 400282 7778.2 BC014433 Z49835 D16234 U42068 D83485 NM.005313 AL535156 AL533202 AL533596 AL531770 AL542767 AL551050 AL548510 AL542531
AL548618 BE799237 AL547374 AL560312 AL543505 AL540727 AL541255 BG765697 AU126498 BI829574 BG576125 AL519304 AL548821 AL542983
BI596431 BI829284 AL045490 BE407984 BI668702 BI713725 BE547233 BM312673 BG822625 AW239512 BM312685 BE296719 BM312059 BI712618
BM309832 BI712859 BE513604 BM310042 BI712817 BG470156 AA305870 AW408391 BE298661 BG826781 BF726062 BM315135 BG472541
BF724689 AA353713 BF477104 BI838605 BG170854 BE612762 BF917301 BF332271 BI049186 BE715514 AW392181 BE768470 AI912855
AW991405 BG739837 AA287804 AW801855 AL568814 AW384099 AW384058 AW754178 AI001019 R33917 BE814037 AI557164
417282 2142.2 AK025474 U11293 AF141304 BM424202 AL539879 AL554793 AL543707 AL549509 BI753328 BG756797 BI856494 BE901116 AL556989 AU133347
BI838505 AW949559 BM012604 BG773980 BG661309 BI260149 BF436764 BG983060 BF822225 BI059728 BF917866 BF917609 BF914374 D31003
AA234218 AJ420466 BM083921 BE856788 BE669957 BF430992 AW614978 AW205958 BF110763 BF222758 AA195232 AI341353 AI698676
AI093230 AI123522 AI656594 AI208758 AA975916 AI089224 AI264922 AA256604 AA659637 BE218707 AA195203 AW999239 AW139706 N31717
AW205941 R95955 N39147 BM015411 AL576975 BF689524 AL563130 BI858155 AA417889 AL513995 AL568815 AU160693 AA836028 H84388
AL517078 AL546480 AL530507 AL561042 AA024435 W47314 AI680513 AA456116 BF836679 AW975173 H24039 AW105059 BE548113 AW370257
BM011139 AW675130 BE276045 BF933396 AL517903 AA886367 BI030596 BG477193 BF973867
446019 658727.1 AI362520 D25917 AI670784 AI742347 AW269789 AI270700 AW610541 AW793036 AW793035 AW610540 AW362220 AW362166 AW362214
AW362225 AW362228 AL119827
400222 9287.3 NM.002082 L16862 BG828886 BE795217 BE904064 BE294526 BE297283 BE394617 BE935127 BE935106 F12351 BG823182 H16710 409760 865166.1 AA302840 T93016 T92950 AU184997 AA077551 438619 35124.1 NM 016575 AB032773 AI765521 BF593742 AI497757 AI761233 AW467938 BF000670 AI818496 N24761 AL043306 BF476138 BF593836 AA132787
AI147248 AI086795 AA151317 T95298 AW083548 AA058371 N27951 AI769860 AI784548 AW205506 AI800679 AI041733 AI459902 BE327641
AI865829 AI254736 AI302433 AI744176 AI241825 AA027842 AL524933 AL524932 BF947764 BF340737 BF948700 BG996395 N53455 N21027
AI127616 N35901 AA682443 AA678249 AA719371 AA132582 T15981 H99958 N40717 AW959402 AI267251 BF909329 AI142035 T95379 H29420
R59632 H17318 H17331 H29327 R40829 R43395 R59573 AI749561 R56599 H16755 AI694500 AA027907
408208 642734 1 BI757837 AW439843 AW172765 BE018717 BE464329 BE302285 H96902 BF477981 BE674508 BE670755 H95980T15387
400236 231.3 M80359 NM.002376 AU132239 AU120606AU124963AI065116 BE900808 BF968374 AI806648 BG774205 AW250728 BE265845 AA290719
AU125196 BG428863AA333580 AA604551 W73300 AI932646 AA082201 AA627618 BF038887 BF337051 BI021159 AW057581 AI983156 AI268004
T71931 T90093 AW194009 H93969 AI742843 AI935080 BE041751 H93970 AW797399 W05032 T87824 T82912 AW129639 AI221821 AI911810
AA703093 AA160135 AW779124 AA102559 AA969546 D29560 BI915937 AA707716 BI085679 AA700887 AA081085
416730 1988296 1 H80564 T9993 T70802
425996 138046.1 BM006551 AA367152 AW953705 AI631833 AW237429 AW027804 AA729038 BE503409 AI521935 BF739953 AA702982 AA557633 AA780065
AI218139 AW194264 D20120 AI082715 AI969980 BE857686 BE326711 AW953706 Al 393749 AI383821 W67199 AI431759 AI796526 AI521794
AI796380 AW117545 AI749657 AI537634 N50122
430441 1438.6 BG108218 BE560548 AW380115 BE269629 AI911518 AW380113 AA902964 AA455001 AI276529 AI685597 AA970496 D61084 AW380068 AW380080
R00283 C15236 AW327776 D80759
437158 59575.1 AL050068 AA160485 AW173544 AW296506 AW439860 AI521563 AI702529 AI393606 AW138323 AA570109 H19504 BM021968 BF063327 BF593552
AA630766 AI597717 AI807128 AA523012 Al 356250 AW451857 AA974203 AI762577 BF512552 AW007307 BE675286 AW450602 AA962057
AW516069 AI582546 BF221924 BF222543 AI801808 AW468599 AW000736 AI866625 AW235356 BM021837 AA911956 AI680606 W86516 T03370
AW611634 H41653 AI468349 H19588 AW090198 AW043993 R39847
412315 1163860.1 AW936678 AW936821 AW936683 AW936822 AW936781 AW936817 AW936811 AW936653 AW936823 AW936685 AW936815 AW936637 AW936812
AW936730 AW936762 AW936682 AW936732
400235 3084.1 BC001179 NM.005336 M64098 BC014305 BI827845 BI918183 AU124191 AU125604 AU140930 AL043307 BG763670 BG824279 AU125959 BI518466
BE271867 BM264138 BE314823 BM090633 BE273657 BG419830 BM048338 AU134368 BE163486 BE163483 BG421980 BG768130 AW50O482
AI910107 AW868323 BF083170 AW450290 BM466817 BG255224 BE394282 AU140278 BE887464 AL042675 BI195986 BE883385 BE544751
BE270148 BM011334 AI093482 AA029803 AI610705 BE386809 F06628 AW408605 BF814085 BC007961 BM451548 BG768053 BM452948 AU140330
BG489566 BI870474 BM014013 AU131264 BG679824 BI225752 BI457400 BE410173 BM044254 BG763690 BE251495 BG179862 BE513489 BM005937 AI064815 BF569858 BI712614 BG655891 BG424940 BE175180 BM313160 BG471936 BM091124 BF885884 BF870522 BE004490 BE712976 BE712862 AA401033 BF569477 BE712936 BF353839 BE713042 AA316561 BE712974 BE712977 BE712938 BE712937 BE712867 BE713043 BE713023 N42463 BE712901 BE713041 BE712904 BE712895 BE713012 BE713049 BE713025 BE712998 BE712988 BE712987 BE712986 BE712984 BE712982 BE712975 BE712970 BE712953 BE712929 BE712922 BE712875 BE712866 BE712861 BE712860 BE712854 BE712853 BE712902 BE712897 BE712912 BG984910 BE712903 BE764759 BE715723 BE715745 BE712915 AA441839 BE713040 BE715755 BF872528 BF060840 BG395104 BG744878 AU124081 AI889823 AI801072 AI633102 AI678670 AI493608 AW194294 AI354559 AI686736 AW152477 AI419496 AI720319 AI866190 AA047013 AA039625 BE049622 AA369065 AA025686 AI570198 AA706304 AW439251 H64553 AW168006 AI983753 AW081999 AW082909 AI951490 BF886341 AW591246 AI190143 AI151074 AI499541 AI050934 AA402167 AA382049 T16207 T03299 AI932691 AW571663 BG479797 BE408436 BI460153 BG386046 BE616601 AW151629 BG236164 BF852743 BF852046 T57801 W37981 AA482668 H43740 W58142 W25087 BM459852 AU125403 BG767992 BE258516 AM 14509BE394494 BE386905 AA450315 BG750593 AA557855 BG766487 BG766998 BF948864 BE279327 BE870900 AA577098 BF365851 AA745058 N29867 AI625038 AA641801 AA846174 H26395 AA025568 BF690282 R67845 R72666 H39554 T78959 W01317 H45860 W80837 N53985 BG757202 BE838055 BE072895 BE072668 BE867012 BM042833AA083591 BG745462 AW374086 BG831326 BE715757 BG767243 BG763272 AA113402 AI024044 BF818501 BE081938 BF353818 AA746336 BM019086 BE712894 H16977 H45012 R10793 BE708619 BF570432 AA593938 AA064637 T28082 AA852845 T78907 AA346590 F00017 BE966368 N58726 AA732431 T54379 W80749 BF238314 BE279768 AA325106 T19241 BE409939 BF852119 W23803 T54011 AW392638 BI465185 AW516784 AA211335 BI159846 AA064680 N80615 W49676 BF851406 R88120 AA434028 H44546 T61029 N44804 AA114948 H26960 BI261965 AA582599 BG469385 BF818172 BF923672 BI024270 AW3626338E883122 BM470779 BE935760 AW856056 AW856103 BE828607 AW381799 AL121058 BE828618 BE769545 AA102142 8G749978 BI770417 BI862544 AH 10687 AF063562 BE740347 BE874864 AI305113 BE513675 BE091369 BI046660 BE091 53 BI046548 AI673786 BF868704 AI025179 BF356840 BF886357 BF886313 BG951884 AI347880 AW627563 BF932536 AW820377 BF739372 BF831620 BE068264 BE613627 AA641745 W01130 H28252
418166 18858.1 AK055915 BE867252 AI523348 AA765350 BF446858 Z43675 R19529 AL133837 BG389444 AW382942 BE702956 AA081961 BE835247 BE835308 BE835295 AA376302 BE645790 AA375690 AA376592 AW954423 N85732 AA249770 AI754416 AA213816 BF592044 AA811729 AW514842 AI633486 AI096810 AW183016 AI635738 N27524 BE645916 AI247842 AW991230 AI754277 H16814 AI766892 BF108422 AI800361 T95129 F11313 R97946 R93989 AA375242 BF109388 AI860939 AI680060 AW953899 BF971486 AI972337 AW953841 AA372437 AI216746 H11384 R38484 AA249043 AA249732
455839 15188421 BE145823 BE145830 BE145884 BE145814 BE145905 BE145833 BE145834 BE145883 BE145889 458997 11847.4 BM453041 AA760783 BE218582 AI340046 AW166131 BF515854 AI630296 AA461307 AI090881 AW023059 AA155797AA115486 AL597396 AW889004 AW937420 AA137082 AA013374 BG619478 BG401839
406782 00 AA430373 AA968771 417324 292720.1 BG775668 BG680336 AW991605 AA455904 AW265494 AW265432 BF911380 AA456370 BF911379 AA195677 BF914311 BF913866 BG775059 BG951874 AI572169
419200 9531.1 BF036043 AW190446 BG194731 AW662036AI445021 BE937550 AW818972 AW393132 AA834685 BF112058 AV721682 H16423AI270167 AI857345 AA937302 AW818444 BE929780 BG4986788F155010 BI598271 BI599811 BE161728 AW578737 AW753711 AW379707 AW381918 BG506608 AW028637 AW994240 BF887392 BF790073 AW381624 AV727105 BF439618 AA443174 AI018009 N42850 AW573242 AI417258 AA463483 AI676131 AI167170 AA836627 AA443828 AW592922 AA235129 AA730278 AW439062 AW474332 BI043239 AW474342 BG708553 AW362423 BF090028 BE827256 R16550 R39478 R39479 R94368 BG540916 BM314745 AA251087 054231 D55274 BF085805 D31589 AW966405 AW994425 D81879 BE093545 AW901107 AA38352981021552 R56420 N39976 AA573281 H82595 AA234955 BE093539 AW367006 BF358697 BF366318 AA663856 BE702099 BF035969 AI267384 AI267232 BE348320 AA621574 AA861212 BF083343 BF083341 AV745131 D53074 AW954476 AW954472 AA376836 AV724531 D53063 C14928 AA093287 AA062638 BG483558 BE940050 AA765954 T70171 BE938775 BE940057 D53502 AW373300 AL118798 BM128728 AA193411 AW444709 AW952455 AI8876128F431948 BI496876 AI264159 BM128481 AI624657 AI689301 AI969467 AA861685 AA251595 AA625761 AA872090 AI826790 AA328366 BE827416 R75951 D56918 R68122 BE827384 AL118797 AI184164 AA164411 BI495332 BE858113 AI863860 H00660 T69849 AW780389 C14667 BE934995 BI018652 R92801 AA164410 H00752 AW373305 AW373299 AW373302
455705 77478.2 BF971018 BE513812 AA133359 AW581719 BF434402 AL600619 BG699731 BI551395 AW027136 AW055130 BF939512 AI076048 H18584 AW161061 AA864334 AI816101 BE049456 AW044012 AA954079 AI274682 AI370526 AW131990 AA853195 AA853191 BG118295 AA761620 BG705371 BF355591 BF336596 AA360497 H28072 BG198352 AW364709 H40926 H44214 AA836538 BI059563
406851 0 0 AA609784 R97304 427239 20459.2 AL532360 BE794750 AA582906 AI015067 AW271034 BG271636 AW075177 AW071374 AI345565 AI307208 BE138953 BE049086 AI334881 AW075006 AW075181 AA464019 AW302733 AW075100 AW073433 AI802854 AI334909 AI802853 AI345036 AI348921 Al 340734 AI307478 AI251289 AW302327 AW072520 AI312145 AW073656 AW072513 AW071289 Al 307559 AA876186 T29587 AI307493 AI255068 AI252868 AI252839 AW074809 AI252926 AI252160 AI251662 AI251262 AI610913 AI270787 AI270156 AI252075 AW073469 AW072901 AW072496 AW071420 AI305762 AI254764 AI802837 AI251264 AW073049 AW071311 AI340643 BE138965 BE138502 AW073456 AI334733 AI054335 BE 139260 AI054302 AI054060 AI054057 AI053722 AI289711 BE139228 AW470478 AW271039 AW302085 BE041872 AI254494 AI271496 AI252427 BF718773 BF718645 AW074866 BE857822
427289 1820.2 BC007350 BG766159 BG769338 BG761999 BG744385 BG770572 AW370610 AW370581 AA978353 AW327973 AW402425 AI889380 AA868504 AW612968 AA630644 AI751211 N26980 AI394506 AA747849 BF154926 BF477185 AA649647 R39135 AI750216 T35363 W36278 AW079375 AW612240 AA505495 AA515380 BG760793 AW370651 BG766029 AW370595 BF229885 BG762422 BG764907 T50662 AA025671 AW815715 AV703420 H65047 AA485582 R56186 H90385 R55913 BI261497 BI018403 BF376945 T75578 BF933325 BF932853 BG502266 AW868934 AV683504 BI018121 N41953 BF933343 BF932871 H08334 R14012 BF897622 T50816 BG698803 BF340083 Z20199
411825 7891.1 AK000695 AK000489 BC001688 BG235988 AW006329 AI887644 AI207230 AI148213 AI304333 AI634653 AW662636 AI281247 AA946921 AA424487 BE272330 AI830588 AA159183 AA977141 BG231801 AA631793 AA975194 BF817537 AA477798 BI906631 AW083424 AA625199 NM.017767 AK000334 BF984048 AW815634 AL573992 AA430612 AA928390 AA464447 AW340827 AA424290 AI927759 BG951502 AW881353 BI765535
406827 0.0 AA971409 428342 6712.1 AK056315 AI015524 AA724079 BI713619 AI377728 AW293682 AI928140 AI092404 AI085630 AA731340 BM469629 AW968804 AA425658 AA769094 BF446026 AW118719 Al 332765 AW500888 AW576556 AI859571 AW499664 AW614573 AW629495 AW505314 W74704 AI356361 AI923640 AW070509 AI521500 AL042095 AA609309 AA761319 AI381489 H45700 AA761333 AW265424 AA909524 AA635311 AA649040 AI392620 Z40708 AI985564 AW263513 AA913892 AI693486 AW263502 AI806164 AW291137 BI061872BI059498 AA134476 AW084888 AA036967 AW370823 T55263 BI002756AA489664 BF827261 W74741 BF963166
449444 2735.1 U59185 NM.004696 AV734324 AI245349 AA369517 H88760 D79128 AA970406 H01059 H88761 H03446 BG620383 AU135008 AU136895 AU158158 AU155762 R73608 R65751 R23756 N74630 AW078687 BE439761 BE786351 R68994 BE785867 AW297502AW297S53 BG431545 AW814843 BF382644 BG429539 BE929862 BF811258 432665 27095.3 BG165971 BE143233 AL577712 AI400326 AA769318 AA427866 AW088714 AI150755 AI924874 AI186243 AA804195 AA768972 AW574769 AW341643 AW20452O AA235326 AI005076 BE826687 AW004816 AW007235 BE826639 BE826634 BF222941 BE826631 BE826643 AA292639 AW514133 AI690331 AI673409 AA627727 AI923685 AA931499 AI249783 AI810663 AA548622 AA702095 AA832395 BI259508 AA262993 AW075840 AA810885
TABLE 51 C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publication endtled The DNA sequence of human chromosome 22' Dunham, et al (1999) Nature 402489-495
Sfrand Indicates DNA strand from which exons were predicted Nt.posidoπ Indicates nudeodde positions of predicted exons
Pkey Ref Strand NLposidon 402075 8117407 Plus 121907-122035,122804-122921,124019-12416 400860 9757499 Minus 151830-152104,152649-152744
402609 9926446 Minus 113464-113633,114264-114654
400750 8119067 Plus 198991-199168,199315199548
402994 2996643 Minus 4727-4969
403817 8962065 Plus 110297-111052
402829 8918414 Plus 101532-101852,102006-102263
403532 8076842 Minus 8175581901
405451 7622517 Minus 145949-146227
405785 9581533 Minus 98702-98925
405506 6466489 Plus 80014-80401,80593-81125
405486 6651379 Plus 179441-179598
406382 9255148 Plus 122336122851
401454 9186923 Minus 114659-114832
405885 7677703 Minus 42574-42998
403969 8569909 Plus 31237-31375,32405-32506
400533 6981826 Minus 277132-277595
400991 8096825 Plus 159197-159320
401591 9966977 Minus 55410-55835
404067 3282162 Plus 14152071
404140 9843520 Plus 37761-38147
401914 9369520 Plus 62537-62945,6315563308
404700 9800123 Minus 159621-160203
403043 7768753 Minus 314425316252
402408 9796239 Minus 110325110491
TABLE 52A ABOUT 204 GENES UPREGULATED IN PRIMARY MELANOMAS RELATIVE TO MELANOMA METASTASES
Table 52A lists about 204 genes upregulated in pnmary melanomas relative to melanoma metastases Genes were selxted from 59680 probesets on the Eos/Affymetox Hu03
Genxhip array Gene expression data for exh probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflxdng the relative levd of mRNA expression
Pkey Unique Ex probeset idendfier number
ExAccn Exemplar Accession number, Genbank xcession number
UnigenelD Unigene number
Unigene Title Unigene gene dtle R1 90th percendle of pnmary melanoma Als divided by the 90th percendle of melanoma metastasis Ais
R2 90th percentile of pπmary melanoma Als divided by the 90th percendle of melanoma metastasis Als, where the 15th percendle of nomial tissue Als was subtrxted from both the numerator and denominator
Pkey ExAxn UnigenelD Unigene Tide R1 R2
421948 L42583 Hs 334309 keradn 6A 21 90 1666
422168 AA586894 Hs 112408 S100 calcium-binding protein A7 (psonas 21 36 4365
401781 Target Exon 18 70 18 58
401780 NM.0O5557* Homo sapiens keradn 16 (fxa 1534 1600
431360 NM.000427 Hs 251680 loncπn 12 34 986
409632 W74001 Hs 55279 senne (or cysteine) proteinase inhibito 11 24 873
412636 NM.004415 desmoplakin (DPI, DPII) 11 20 662
417366 BE185289 Hs 1076 small prodne-nch protein 1B (cornifin) 10 46 1275
409601 AF237621 Hs 80828 keradn 1 (epidermolytic hyperkeratosis) 1041 2549
420859 AW468397 Hs 100000 S100 calcium-binding protein A8 (calgran 920 863
420783 AI659838 Hs 99923 Ixdn, galactoside-binding, soluble, 7 8 11 11 14
422511 AU076442 Hs 117938 ∞llageπ, type XVII, alpha 1 790 892
422158 L10343 Hs 112341 protease inhibitor 3, skm-denved (SKAL 7 14 22 14
427666 AI791495 Hs 180142 calmodulin-like skin protein (CLSP) 703 890
430686 NM.001942 Hs 2633 desmogleiπ 1 688 539
431369 BE184455 Hs 251754 sxretory leukxyte protease inhibitor ( 660 12 79
456525 AW468397 Hs 100000 S100 calcium-binding protein A8 (calgran 644 619
437191 NM.006846 Hs 331555 senne protease inhibitor, Kazal type, 5 634 777
422166 W72424 Hs 112405 S100 calcium-binding protein A9 (calgran 6 15 891
418067 AH 27958 Hs 83393 cystadn E/M 608 924
408536 AW381532 Hs 135188 ESTs 604 1740
402075 ENSP00000251056" Plasma membrane calcium 596 841
413554 AA319146 Hs 75426 sxretogranin II (chromograiin C) 546 332
410001 AB041036 Hs 57771 kallikrein 11 5 38 5 36
421100 AW351839 Hs 124660 Homo sapiens cDNA FU21763 fis clone C 532 384
407788 BE514982 Hs 38991 S100 calcium-binding protein A2 5 19 530
419329 AY007220 Hs 288998 S100-type calcium binding protein A14 503 794
429504 X99133 Hs 204238 lipxal 2 (oncogene 24p3) (NGAL) 4 86 522
421773 W69233 Hs 112457 ESTs 482 1241
442577 AA292998 Hs 163900 ESTs 4 82 440
401760 Target Exon 460 11 03
408522 AI541214 Hs 46320 Small proline-nch protein SPRK [human, 450 11 35
417515 L24203 Hs 82237 ataxia-telaπgixtasia group D-assxiated 4 47 1243
431211 M86849 Hs 323733 gap junction protein, beta 2, 26kD (conn 445 299
446989 AK001898 Hs 16740 hypothetical protein FU11036 4 39 4 23
423017 AW178761 Hs 227948 serine (or cysteme) proteinase inhibito 438 4 55
418663 AK001100 Hs 41690 desmocollin 3 436 5 16
424620 AA101043 Hs 151254 kallikrein 7 (chymotrypdc, stratum com 429 5 19
401747 Homo sapiens keradn 17 (KRT17) 428 541
414807 AI738616 Hs 77348 hydroxyprostaglandin dehydrogenase 15(N 4 24 230
411274 NM.002776 Hs 69423 kallikrein 10 4 22 4 82
439496 BE616501 Hs 32343 Homo sapiens, Simila to RIKEN cDNA 1110 4 21 826
420039 NM.0O4605 Hs 94581 sulfotransferase family, cytosolic, 2B, 4 18 4 73
429538 BE182592 Hs 139322 small prolme-nch protein 2A 4 16 730 418686 Z36830 Hs 87268 annexin A8 4 12 409
407366 AF026942 Hs 17518 gb Homo sapiens cιg33 mRNA, partial sequ 408 2 13
421733 AL119671 Hs 1420 fibroblast growth fxtor rxeptor 3 (xh 408 4 38
416091 AF295370 Hs 283082 defensin, beta 3 405 538
442757 AI739528 Hs 28345 ESTs 394 4 28
427318 AF186081 Hs 175783 zinc transporter 392 307
453309 AI791809 Hs 32949 defensin, beta 1 390 430
422192 AA305159 Hs 113019 flε485 388 281
424012 AW368377 Hs 137569 tumor protein 63 kDa with strong homolog 386 503
429365 AA451798 Hs 99249 ESTs 376 405
423634 AW959908 Hs 1690 hepaππ-bindmg growth fador binding pr 372 635
425580 L11144 Hs 1907 galanin 368 365
448966 AW372914 Hs 86149 phosphoinositol 3-phosphate-bιndιng prot 368 275
444946 AW139205 Hs 156457 hypothedcal protein FU22408 359 572
408591 AF015224 Hs 46452 mammaglobin 1 358 473
431009 BE149762 Hs 48956 gap juncdon protein, beta 6 (∞nnexm 3 358 262
438501 Z44110 Hs 86149 phosphoinositol 3-phosphate-bιndιng prot 356 261
421574 AJ000152 Hs 105924 defensin, beta 2 356 404
402294 Target Exon 348 438
428666 AL080190 Hs 189242 Homo sapiens mRNA cDNA DKFZp434A202 (fr 344 295
401785 NM.002275* Homo sapiens keradn 15 (KRT1 342 492
418007 M13509 Hs 83169 matnx metalloproteinase 1 (interstitial 336 424
418394 AF132818 Hs 84728 Knippel-like fxtor 5 (intestinal) 331 542
452392 L20815 Hs 507 comeodesmosin 330 856
445183 AB007877 Hs 12385 KIAA0417 gene product 330 235
433124 U51712 Hs 13775 hypothedcal protein SMAP31 326 215
419098 AA234041 Hs 87271 ESTs 3 25 434
421978 AJ243662 Hs 110196 NICE-1 protein 3 17 586
445493 AI915771 metallottiionein 1E (funcdonal) 316 298
448111 AA053486 Hs 20315 interferon-induced protein with tetratπ 314 207
445745 AB007924 Hs 13245 KIAA0455 gene product 3 10 239
410268 AA316181 Hs 61635 six transmembrane epithelial andgen of 306 2 71
407839 AA045144 Hs 161566 ESTs 306 354
432374 W68815 Hs 301885 Homo sapiens cDNA FU11346 fis, clone PL 304 464
439706 AW872527 Hs 59761 ESTs, Weakly simila to DAP1 HUMAN DEATH 304 278
452240 AI591147 Hs 61232 ESTs 300 4 79
409190 AU076536 Hs 50984 sarcoma amplified sequence 296 305
408015 AW136771 Hs 244349 epidermal differentiation complex protei 294 10 53
420798 W93774 Hs 99936 keradn 10 (epidermolydc hyperkeratosis 291 301
406964 M21305 FGENES predicted novel sxreted protein 290 534
451541 BE279383 Hs 26557 plakophilm 3 289 664
454027 R40192 Hs 21527 Human DNA sequence from ctone GS1-115M3 286 2 81
414737 AI160386 Hs 125087 ESTs 284 1 76
428330 L22524 Hs 2256 matnx metalloproteinase 7 (matnlysm, 282 1 83
405542 Taiget Exon 280 277
442503 AF147078 Hs 150853 p53-responsιve gene 5 278 5 17
402970 C20000886' gι|9280563|gb|AAF86472 1| (AF 278 3 37
416730 T99937 gb ye72d04 r1 Soares fetal liver spleen 276 276
433435 BE545277 Hs 340959 Ts transladon elongadon fxtor, mitxh 275 276
447164 AF026941 Hs 17518 vipinn, similar to inflammatory respon 272 286
409453 AI885516 Hs 95612 ESTs 270 668
428824 W23624 Hs 173059 ESTs 267 2 75
437233 D81448 Hs 339352 Homo sapiens brother of CDO (BOC) mRNA, 265 307
430630 AW269920 Hs 2621 cystadn A (stefin A) 263 238
433339 AF019226 Hs 8036 glioblastoma overexpressed 261 244
444670 H58373 Hs 332938 hypothedcal protein MGC5370 257 1 4
414602 AW630088 Hs 76550 Homo sapiens mRNA. cDNA DKFZp564B1264 (f 254 366
400995 C11000295* gι|12737279|reflXP 012163 1| 254 293
423515 AA327017 Hs 176594 ESTs 253 736
417359 T99264 Hs 191117 ESTs 253 254
432426 AW973152 Hs 31050 ESTs 252 2 15
413822 R08950 Hs 272044 ESTs, Weakly similar to ALU1.HUMAN ALU S 2 52 305
414987 AA524394 Hs 294022 hypothedcal protein FU14950 252 385
407748 AL079409 Hs 38176 KIAA0606 protein, SCN Orcadian Oscillat 248 1 76
426990 AL044315 Hs 173094 Homo sapiens mRNA for KIAA1750 protein 247 1 92
413392 AW021404 Hs 13021 ESTs 247 2 56
442762 AF035119 Hs 8700 deleted in liver cancer 1 246 1 90
444781 NM.014400 Hs 11950 GPI-anchored metastasis-ass∞iated prote 246 7 90
424364 AW383226 Hs 163834 ESTs, Weakly similar to G01763 atrophm- 246 266
420568 F09247 Hs 247735 protxaihenn alpha 10 246 301
405885 Taget Exon 246 282
412633 AF001691 Hs 74304 peπplakm 246 501
429852 AB010445 Hs 225948 small inducible cytokine subfamily A (Cy 245 335
429624 AA458648 Hs 99476 ESTs, Weakly similar to 13131848 alphal 244 2 33
407325 AA291180 Hs 328476 ESTs, Weakly similar to alternadvely sp 244 2 11
431441 U81961 Hs 2794 sodium channel, nonvoltage-gated 1 alpha 243 366
432543 AA552690 Hs 152423 Homo sapiens cDNA FU21274 fis, ctone C 242 3 12
430168 AW968343 Hs 145582 DKFZP434I1735 protein 241 275
408000 L11690 Hs 198689 bullous pemphigoid andgen 1 (230/240kD) 240 367
404049 NM.018937* Homo sapiens protocadhenn be 2 39 1 89
433576 BE080715 Hs 161091 ESTs 2 39 1 59
444083 AI123195 gb oo17a10 x1 Soares NSF F8 9W OT PA P S 238 2 59
408208 BE018717 ESTs 237 212 431842 NM 005764 Hs 271473 epithelial protein up-regulated in carci 2 36 223
453931 AL121278 Hs 25144 ESTs 234 1 99
452308 AI167560 Hs 61297 ESTs 231 382
431048 R50253 Hs 249129 cell death-inducing DFFA-dke effector a 231 218
403752 NM.002753' Homo sapiens mitogeπ-xtivate 230 238
402525 NM.002699' Homo sapiens POU domain, das 230 236
420223 N27807 nbosomal protein L4 230 1 73
452023 AB032999 Hs 27566 KIAA1173 protein 229 454
443172 AW662964 Hs 199061 p300/CBP-assxιated fxtor 228 202
439979 AW600291 Hs 6823 hypothetical protein FU 10430 228 1 71
414004 AA737033 Hs 7155 ESTs, Moderately similar to 2115357A TYK 2 27 1 81
429554 NM.012275 Hs 207224 interieukin 1, delta 226 2 17
436895 AF037335 Hs 5338 carbonic aπhydrase XII 226 251
404029 NM 018936' Homo sapiens protocadhenn be 226 219
424049 AB014524 Hs 138380 KIAA0624 protein 226 299
442423 BE326264 Hs 246842 ESTs 226 1 75
408452 AA054683 Hs 192455 ESTs, Weakly similar to ALU7.HUMAN ALU S 226 229
428471 X57348 Hs 184510 stradfin 225 240
410541 AA065003 Hs 64179 syntenιn-2 protein 224 246
415539 AI733881 Hs 72472 BMP-R1B 2 22 1 64
425701 AA361850 Hs 240443 Human clone 137308 mRNA, partial eds 222 304
423973 AF038461 Hs 136574 arxhidonate 12-lιpoxygenase, 12R type 222 324
409178 BE393948 Hs 50915 kallikrein 5 2 19 474
433091 Y12642 Hs 3185 lymphxyte andgen 6 complex, Ixus D 219 796
430171 AF086289 Hs 234766 skm-spxific protein 2 17 356
401994 Target Exon 2 14 334
449228 AJ403107 Hs 148590 protein related with psoriasis 211 552
446292 AF081497 Hs 279682 Rh type C glycoprotein 2 11 578
426150 NM 003658 Hs 167218 BarH-dke homeobox 2 205 296
452554 AW452434 Hs 58006 ESTs, Weakly similar to ALU5.HUMAN ALU S 204 4 17
443162 T49951 Hs 9029 DKFZP434G032 protein 1 98 320
400304 AF005082 Hs 113261 Homo sapiens skm-spxific protein (xp33 1 94 320
407395 AF005082 gb Homo sapiens skm-spxific protem (x 1 92 324
412507 L36645 Hs 73964 EphA4 1 92 306
410310 J02931 Hs 62192 coagulation fxtor III (thromboplastin. 1 90 318
425415 M13903 Hs 157091 volucnn 1 89 526
417324 AW265494 ESTs 1 88 382
412446 AI768015 ESTs 1 88 336
451092 AI207256 Hs 13766 Homo sapiens mRNA for FU00074 protein 1 87 375
444726 NM.0O6147 interferon regulatory fxtor 6 1 86 4 11
424399 AI905687 AI905687 IL-BT095190199-019 BT095 Homo 1 85 4 20
434346 AA630445 ESTs 1 84 308
446051 BE048061 Hs 37054 ephπn-A3 1 83 344
423725 AJ403108 Hs 132127 hypothedcal protein LOC57822 1 78 345
413859 AW992356 Hs 8364 Homo sapiens pyruvate dehydrogenase kma 1 76 299
411908 L27943 Hs 72924 cyddme deaminase 1 74 360
445656 W22050 Hs 21299 ESTs, Weakly simila to AF151840 1 CGI-8 1 71 356
413966 AA133935 Hs 173704 ESTs Moderately similar to A53959 throm 1 71 338
424046 AF027866 Hs 138202 senne (or cysteine) proteinase inhibito 1 70 392
425650 NM.001944 Hs 1925 desmoglein 3 (pemphigus vulgaπs andgen 1 68 325
429299 AI620463 Hs 347408 hypothedcal protein MGC13102 1 67 292
429002 AW248439 Hs 2340 junction plakoglobm 1 66 335
421335 X99977 Hs 103505 ARS component B 1 66 431
433662 W07162 Hs 150826 RAB25 RAB25, member RAS oncogene family 1 65 355
429211 AF052693 Hs 198249 gap juncdon protein, beta 5 (connexm 3 1 64 404
414214 049958 Hs 75819 glycoprotein M6A 1 64 359
437897 AA770561 Hs 146170 hypothedcal protein FU 22969 1 62 313
426350 NM.003245 Hs 2022 transglutaminase 3 (E polypepdde, prote 1 62 292
413163 Y00815 Hs 75216 protein tyrosine phosphatase, receptor t 1 57 309
422106 D84239 Hs 111732 Fc fragment of IgG binding protein 1 53 339
427751 AF000152 conserved gene amplified in osteosarcoma 1 52 353
416881 N32520 Hs 141358 ESTs 1 52 306
435013 H91923 Hs 110024 NM 020142 Homo sapiens NADH ubiqumone 0 1 49 291
434574 AI424458 Hs 33470 ESTs 1 48 305
454478 AW805749 superoxide dismutase 2, mitxhondnal 1 48 354
447330 BE279949 Hs 18141 ladinm 1 1 46 448
414583 AA362907 Hs 76494 proline arginine-πch end leucine-nch r 1 41 299
433640 AW390125 Hs 240443 Homo sapiens cDNA FU23538 fis, clone L 1 40 371
427461 AA531527 Hs 332040 hypothetical protein MGC13010 1 36 298
430205 AB025904 Hs 235168 carbonic anhydrase XIV 1 36 3 14
450796 NM.001988 Hs 25482 envoplakm 1 34 374
407394 AF005081 gb Homo sapiens skm-spxific protem (x 1 30 3 26
430513 AJ012008 Hs 241586 G6C protein 1 28 326
411388 X72925 Hs 69752 desmocollm 1 1 22 364
431089 BE041395 ESTs, Weakly similar to unknown protein 1 14 371
444107 T46839 Hs 10319 UDP glycosyltransferase 2 family, polype 1 00 320
443672 AA323362 Hs 9667 butyrobetame (gamma), 2-oxoglutarate di 1 00 326
TABLE 52B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank axession numbers Pkey CAT Number Axession
412636 1438.1 M77830 NM.004415 AF139065 BG681115BG740377 BI712964 BG000656 AA128470 BI438324 H27408 BE931630 BE167165 AW370827 AW370813
J05211 BG698865 BG740734 BG680618 BG739778 BI765807 BM353403 BM353248 AW177784 AW205789 AW951576 AW848592 BE182164 BF149266 BE940187 BI060445 BI060444 BF350983 BE720095 BE720069 BE715154 BE082584 BE082576 BE004047 AA857316 BI039774 BE713818 BE713548 AW170253 BE160433 BI039775 AW886475 BM462504 BE931734 BF 149264 AA340777 BF381183 BG621737 AU127260 AW364859
BF993352 BG223489 BE819009 BF381184 BE715956 R58704 AA852212 AW366566 BI090358 BF087707 BE819046 BE819005 AA3771278E073467 BE819069 BE819048 BI036306 BG990973 BI040954 BF919911 AU140155 AI951766 AI434518 AW804674 BF752969 BE837009 BE925826 BF149265 AW995615 BE814264 BI039782 AU140407 BE144243 BE709863 BF985642 BE001923 BF933510 AW265328 BG436319 BE182166 AW365175 AW847688 BE818280 AW177933 BF873679 AW178000 BE082526 BF476866 BF086994 BF592276 BEO82507 BE082514 BE082505 BF873693 AW068840 AW847678 BF804153 AW365157 BE813930 BE002030 AW365153 BE184941 BF749421 BE184920 BF839562 BE184933 BF842254
BE698470 BE931048 BF999889 BF368816 BE184924 BE159646 BE714632 BE184948 BG986845 AA131128 AA099891 39488 C04715 BF096124 BE865341 AW799304 AL603116 BE149760 BE705967 BE705966 BE705968 AW848723 AW376699 AW376817 AW376697 BG005097 BF751115 BE696084AW848371 AW376782 AW848789AW849074AW361413 BF927725 BF094211 AW997139 BE865474 BE185187 BE156621 BE715089 BE713297 BE713298 BE179915 AW799309 BF872345 BF088676 BE705939 AW752599 BG005197 BF350086 BE715196 BE715155 BF752396 BF093817 BF831190 BF752409 BEO06561 BG959922 BF094833 BF094748 BF094583 AW377699 AW607238 BE082519 AW377700 BF349467
AI190590AI5544O3AI392926AU158477 BI467252AU159919AI76O816 BF082516 AI439101 AA451923AI340326AI590975 BI791553AI7OO963 Al 142882 AA039975 AA946936 AA644381 BM314884 AA702424 AI417612 AW190555 AI220573 AI304772 AI270345 AI627383 AA552300 AI911702 AW166807 AI346078 W95070 AA149191 AA026864 AI830049 AW780435 AI078449 AI819984 AI858282 BI468588 AI860584 AI025932 AA026047 AA703232 AA658154 AA515500 AW192085 AA918281 T77861 AI927207 AI205263 BF082491 AW021347 AI568096 BE939862 AA088866 D12062 AA056527AA782109 W19287W02156AW150038AA022701 T87181 H44405AI910434 BF082513AI494069AI270027AI635878AA128330
BG681425 BE706078 R20904 BG680059 BG676647 BF764409 AA026654 AV745530 BI762796 BG287391 AW798780 BE706045 BE926470 AW799118 BF087996 BE002273 AW879451 AI571075 BE067786 AV721320 AI022862 N29754 C03378 N84767 AA131077 H30146 BE714290 AI686869 AI568892 AI915596 AW105614 AI887258 AI538577 BE926474 BE067737 BG319486 AA247685 AW798883 AW103521 BF989173 AW860878 BE939707 BE185750 BE714064 BE713903 BE713868 BE713763 BG950164 BE713810 AW365151 BG955489 BE005272 BF915937 AW365148 AI9059278F992780 AW853812 BG954443 BI770853 BG679406 BG740832 BG681087 BG698430 AA455100T87267 BE696209 BE696210
BI089483 BE006273 BE872225 AW391912 BE925515 BG677012 BG741970 AA0264808E705999 BG677157 BE009090 BG681378 BE712291 BG961498 BG678984 BI040941 AA337270 AW384371 AW847442 BI058659 BE813665 W95048 W25458 AW177786 AA025851 BE931733 BF154837 BG949393 BE714441 AW996245 BE711801 AI284090 BE064323 BE719390 BE940148 BG991212 BF375714 BF349522 BG996267 T48793 BI013292 BE001925 AW365156 AW365154 AW606653 BF763109 BE931637 BE167181 BE713879 BF354008 BF678726 H90899 AW365145 W38382 AI498487 445493 423456 1 AV711317 AI809938 AI808768 AI240593 AI915771
416730 1988296.1 H80564 T99937 T70802 444083 10908 12 BI836699 A1123195
408208 642734.1 BI757837 AW439843 AW172765 BE018717 BE464329 BE302285 H96902 BF477981 BE674508 BE670755 H95980 T15387 420223 191648.1 N27807 AA256634 BE276324 417324 292720.1 BG775668 BG&80336AW991605AA455904AW265494AW265432 BF911380AA456370 BF911379AA195677 BF914311 BF913866 BG775059
BG951874AI572169 412446 63467.1 BC021735 AI669212 AL120184 AI769949 BE701002 BE184363 BE819031 BG702238 BF090049 BF963318 BF961912 BF943013 AA93451 AA151245
BF960659 AA987907 Z41449 BF908059 BF908053 BF908049 BE699424 BF908060 BF962832 BF952020 BF963134 BI035538 BF908052 BF908057 BF090026 BF943158 AI632924 BF512340 BF952021 BF960776 BF943437 BF942847 AI768015 F09778 F04816 F02721 AA102645 AI633838 AA617929 BF947001 BI035448 BE935876 AW890837 AW898604 BF957405 BF963433 BG704815
444726 3503.2 BG285809 BE940673 BG432524 BE157554 BG676980 AU144284 AI745383 AU159045 AI693500 AW293668 AW371408 BE856107 AI338042
AW188320AI698246 BE673290AW297653AA156532AI017342AI916754AI190644AI184302AA857671 BE857018AI307420 AI318157 AW204327 AW664668 AW274339 AA582788 AI345741 AW301433 AI873468 AW137388 BF718731 BF718413 AA877495 BF001575 AI824693 AW849604 AW849405 AW849396 AW849173 BE673179 AI611327 AA705753 BE715478 AW849414 AW849399 AI085759 AI140849 T67412 AI889885 A 104647 AI912495 AI889874 AI744241 BE717113 BE717108 BE715564 AI872527 AA029457 C00338 AI469558 BE715577 AA045413 BF843813
424399 2196 1 NM.058173AF414087W72837 BF742809AW070916 BE092421 AI905687 AA340069 BE074512 AI905623 AI905633 BG202312 W72838 AI139456
BG218084 BE926938 BE186013 AW176044 AW291950 BG185269 BG197186 BG192597 BG183176 BG207535 AI127172 BE815819 AI905624 R75793 BG202313 AI905837 BE815853 434346 MH1094.14 AK056896 AI924216 AI660493 AI984141 AI991272 AA593860 AI983793 AI346155 AI274929 AI281211 AI821178 BC020841 BF352476 BF843140 BF917041 W80832 AA630445 BF350167 BE162052 BE931808 AI572329 BG536379
427751 15028.1 BE875818 AW751975 W39241 BF808798 W2260O BF082190 AA031290 R42801 H98235 H17925 AI631236 AI933786 H42736 AF000152 AU123911
AW410526 BM354207 BF800492 BM142340 BE019322 AL597008 AW327818 BI041915 AW504825 AW504941 BF987969 NM.005730 U81556 AI422831 AU154008 AA147822 AA873109 AI089244 AI360868 AW168024 AI819848 AA811327 AI355616 AA281629 AI880578 AI274316 AW014622 AI268660 AI270283 AA171981 AI349410 AA402469 AI421985 AI004864 AI423497 AI361503 AI363096 AW805345 AL539979 AA553967 AW502264 A1290698 N22420 AI281054 AI500699 AW342095 C75122 AW504577 AI1S0811 AI423567 R79086 AI860451 BE222885 AI697830AI279575 BF438693
AW576277 BE218210 AI952376 AA506609 AI147566 AI391690 AA991622 AI696368 AI784664 AA741555 AI002681 AW474554 AW474508 D25623 AI493929AA179800W73566AW411368AA147971 AA088581 BF804510AU145809AU148108AA223219AU157840AW169757AI537862 42341 AI128667 AW327853 AA713915 W15255 W56743 AA058322 H81878 AA723464 N27523 R37745 AA613566 AL526353 AI905211 BF802713 N40338 AA249397 BF752939 BE250441 H64761 BF853011 H81877 H96088AL576453W73585 H3999OAW438965 BF899684AI040299AL561879AA293821 H27760 BC018922 AL533396 BE513580 BF432649 AI884985 AA404264 AW024396 AW167863 AW027036 AI302177 AI660487 AW026086 BF432564
BF091011 AI193156 AA744623 AI859510 BI063081 BI061541 AA777036 BG058486 BI063555 AI349411 BF874521 AW139801 AI268585 AA401267 AI905209 R64276 N72043 AF022231 BI256540 AU134437 BG826972 BE298386 AW134499 AW206089 BF846730 AW500331 BF849336 BI041697 AI857745AW192840AW410527AI697435AW006631 AW5O4124AL048926AI085476 AW327855AA459344AW207516AW2O4875 BM142514 BF436650AA960980AW242609 BI012363AW837102 BE703126 BE814612BE837981 BE703141 BF343101 R47375AA031413 N40264 BG027363 BF526360 BE391263 AA280192 BE294042 BE250630 AU147734 AU146610 AA196787 N59465 AW575791 H16738 H96089 H64762 AW006603
BE857292 AI719393 AU155418 BG770385 AA339673 BG337748 H42694 BE834346 AA090896 BE619985 BMO06968 R46008 BF304621 AA172280 AW957721 8F304885 BF933455 BF809973 BG386280 AW079808 T51091 AL520569 BE694350 T06360 BF347780 BE560703 BE296629 454478 4273.16 AW796921 AW798102 AW805749 AW805872 BF985060 AW794380 BF380449 AW794466 AW794538
407394 27110.2 AF0O5081 BG193848 431089 125941.2 BG940189AW063489AA715980 BF001091 BF880066AA666102AA621946 AA491826
TABLE 52C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publication endtled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted Nt.posidon Indicates nucleotide posidons of predicted exons
Pkey Ref Strand Ntjosidon 401781 7249190 Minus 8321583435,83531-8365683740-83901,8423
401780 7249190 Minus 28397-2861728920-290452913529296,2941
402075 8117407 Plus 121907-122035,122804-122921,124019-12416
401760 9929699 Plus 8312583250,85320-85540,94719-95287 401747 9789672 Minus 118595118816,119119-119244 119609-11976
402294 2282012 Minus 25753000
401785 7249190 Minus 165776165996,166189-166314,16640516656
405542 9857564 Plus 71331-72183
402970 9650703 Minus 124891-125049
400995 8099094 Plus 141186141601
405885 7677703 Minus 42574-42998
404049 3688074 Minus 7576578155
403752 7678857 Plus 33704-33828
402525 9800048 Minus 1974520683
404029 7671252 Plus 108715111112
401994 4153858 Minus 42904-43124,43211-43336,44607-447634519 TABLE 53A ABOUT 298 GENES UPREGULATED IN MELANOMA METASTASES RELATIVE TO PRIMARY MELANOMAS
Table 53A lists about 298 genes upregulated in melanoma metastases reladve to pnmary melanomas Genes were selxted from 59680 probesets on the Eos/Affymetnx Hu03
Genxhip anay Gene expression data for exh probeset obtaned from this analysis was expressed as average intensity (Al), a nomialized value reflxdng the reladve level of mRNA expression
Pkey Unique Eos probeset idendfier number ExAxn Exemplar Axession number, Genbank axession number
UnigenelD Unigene number
Unigene Title Unigene gene dtle
R1 90th percendle of melanoma metastasis Als divided by the 90th percendle of pnmary melanoma Als
R2 90th percendle of melanoma metastasis Als divided by the 90th percendle of pπmary melanoma Als, where the 15th percendle of nomial dssue Als was subtrxtx- from both the numerator and denominator
Pkey ExAxn UnigenelD Unigene Title R1 R2
407245 X90568 Hs 172004 ddn 1056 11 32
412228 AW503785 Hs 73792 complement component (3d/Epsteιn Ban vi 922 614
426752 X69490 Hs 172004 ddn 878 1044
418310 AA814100 Hs 86693 ESTs 865 649
414522 AW518944 Hs 76325 Immunoglobulin J chain 837 4 39
433447 U29195 Hs 3281 neuronal pentraxin II 8 27 725
456373 BE247706 Hs 89751 membrane-spanning 4-domaιns. subfamily A 7 78 670
425545 N98529 Hs 158295 Homo sapiens, clone MGC 12401, mRNA, com 749 902
428087 AA100573 Hs 182421 troponin C2, fast 745 765
436485 X59135 Hs 156110 immunoglobulin kappa constant 7 35 618
414646 AA353776 Hs 901 CD48 andgen (B-cell membrane protein) 697 575
412519 AA196241 Hs 73980 troponin T1, skeletal, slow 6 15 6 33
430280 AA361258 Hs 237868 interieukin 7 receptor 607 3 11
449078 AK001256 Hs 22975 KIAA1576 protein 605 855
437952 D63209 Hs 5944 solute earner family 11 (proton-coupled 603 536
412561 NM 002286 Hs 74011 lymphxyte-xtivation gene 3 585 557
431574 AW572659 Hs 261373 hypothedcal protein dJ434014 3 574 640
458079 AI796870 Hs 54277 DNA segment on chromosome X (unique) 992 572 4 76
417880 BE241595 Hs 82848 selxhn L (lymphxyte adhesion molxule 571 500
429412 NM 006235 Hs 2407 POU doman, class 2 assxiadng fxtor 569 384
420338 AA825595 Hs 88269 Homo sapiens, clone MGC 17339, mRNA, com 537 4 12
430580 AA806105 Hs 300697 immunoglobulin heavy constant gamma 3 (G 531 602
428804 AK000713 Hs 193736 hypothetical protein FU20706 529 797
410361 BE391804 Hs 62661 guanylate binding protein 1, interferon- 5 26 293
445784 AI253155 Hs 146065 ESTs 512 310
409461 AA382169 Hs 54483 N myc (and STAT) interxtor 505 341
414020 NM 002984 Hs 75703 small inducible cytokine A4 (homologous 4 59 400
420301 AA767526 Hs 22030 paired box gene 5 (B-cell lineage spxif 4 47 392
453857 AL080235 Hs 35861 DKFZP586E1621 protein 446 361
428242 H55709 Hs 2250 leukemia inhibitory fxtor (cholinergic 4 37 322
414829 AA321568 Hs 77436 plxkstπn 435 335
417878 U90916 Hs 82845 Homo sapiens cDNA FU21930 fis, clone H 435 268
422603 BE242587 Hs 118651 hematopoiedcally expressed homeobox 4 27 267
451099 R52795 Hs 25954 interieukin 13 receptor, alpha 2 4 27 367
441623 AA315805 desmoglein 2 4 24 366
422241 Y00062 Hs 170121 protein tyrosine phosphatase, receptor t 422 360
417022 NM.014737 Hs 80905 Ras assxiation (RalGDS/AF-6) doman fam 420 258
426317 AA312350 Hs 169294 transcnpdon fxtor 7 (T-cell spxific, 4 16 582
430770 AA765694 Hs 123296 ESTs 4 15 5 10
420931 AF044197 Hs 100431 small inducible cytokine B subfamily (Cy 4 12 506
406707 S73840 Hs 931 myosin, heavy polypeptide 2 skeletal mu 411 382
444863 AW384082 Hs 104879 senne (or cysteine) proteinase inhibito 4 10 268
432306 Y18207 Hs 303090 protein phosphatase 1 , regulatory (inhib 404 4 10
417105 X60992 Hs 81226 CD6 andgen 403 451
409041 AB033025 Hs 50081 Hypothedcal protein, XP.051860 (KIAA119 402 372
432485 N90866 Hs 276770 CDW52 antigen (CAMPATH-1 antigen) 399 487
415165 AW887604 Hs 78065 complement component 7 397 398
421181 NM 005574 Hs 184585 LIM domain only 2 (rhombodn-like 1) 396 319
421712 AK000140 Hs 107139 hypothedcal protein 395 734
408380 AF123050 Hs 44532 diubiquidn 394 245
422423 AF283777 Hs 116481 CD72 antigen 393 329
408989 AW361666 Hs 49500 KIAA0746 protein 390 302
424321 W74048 Hs 1765 lymphxyte-spxific protein tyrosine k 384 340
420137 AA306478 Hs 95327 CD30 andgen, delta polypeptide (TιT3 co 384 484
424922 BE386547 Hs 217112 hypothetical protein MGC10825 378 304
400440 X83957 Hs 83870 nebulm 377 489 418870 AF147204 Hs 89414 chemokine (C-X-C modf), rxeptor 4 (fus 374 391
450293 N36754 Hs 171118 hypothedcal protein FU00026 374 289
432606 NM 002104 Hs 3066 granzyme K (senne protease, granzyme 3 372 265
408548 AA055449 Hs 63187 ESTs, Weakly similar to ALUC.HUMAN »« 372 243
429490 AI971131 Hs 23889 ESTs, Weakly similar to ALU7.HUMAN ALU S 371 223
414821 M63835 Hs 77424 Fc fragment of IgG, high affinity la re 370 236
419749 X73608 Hs 93029 sparc/osteonxtin, cwcv and kazal-like d 367 330
410016 AA297977 Hs 57907 small inducible cytokine subfamily A (Cy 367 6 72
433658 L03678 Hs 156110 immunoglobulin kappa constant 366 249
424153 AA451737 Hs 141496 MAGE-like 2 364 265
421666 AL035250 Hs 1408 endothelin 3 364 592
417696 BE241624 Hs 82401 CD69 andgen (p60, early T-cell acdvad 361 269
429732 U20158 Hs 2488 lymphxyte cytosolic protein 2 (SH2 doma 360 1 95
422173 BE385828 Hs 250619 phorbolin-like protein MDS019 (CEM15) 359 308
413778 AA090235 Hs 75535 myosin, light polypeptide 2, regulatory, 357 11 26
442379 NM 004613 Hs 8265 transglutaminase 2 (C polypepdde, prote 356 491
439859 AW292872 Hs 124554 ESTs 353 4 15
453064 R40334 Hs 89463 potassium large conductance calcium-xb 351 288
411252 AB018549 Hs 69328 MD-2 protein 346 1 82
414324 Y14768 Hs 890 lymphotoxiπ beta (TNF superfamily, membe 345 465
420286 AI796395 Hs 111377 ESTs 342 247
413385 M34455 Hs 840 mdoleamine-pyrrole 2,3 dioxygenase 342 309
442104 L20971 Hs 188 phosphodiesterase 4B cAMP-spxific (dun 341 222
405545 Target Exon 340 246
416373 AA195845 ESTs, Weakly similar to S12658 cysteiπe- 340 564
417410 AF063020 Hs 82110 PC4 and SFRS1 interxdng protein 1 337 4 27
418522 AA605038 Hs 7149 Homo sapiens cDNA FLJ21950 fis clone H 3 33 237
433470 AW960564 transmembrane 4 superfamily member 1 333 3 13
416975 NM 004131 Hs 1051 granzyme B (granzyme 2, cytotoxic T-lymp 332 251
442149 AB014550 Hs 8118 KIAA0650 protein 330 2 29
411852 AA528140 Hs 107515 ESTs, Weakly similar to T00329 hypotheti 329 3 85
447023 AA356764 Hs 17109 integral membrane protein 2A 324 279
421566 NM 000399 Hs 1395 early growth response 2 (Krox-20 (Drosop 323 1 78
414176 BE140638 Hs 75794 EDG-2 (endothelial differentiation, lys 322 2 90
447513 AW955776 Hs 313500 ESTs, Moderately similar to ALU7.HUMAN A 3 18 4 16
421893 NM 001078 Hs 109225 vascular cell adhesion molxule 1 3 17 359
424148 BE242274 Hs 1741 integnn, beta 7 3 14 229
406648 AA563730 Hs 277477 major histocompatibility complex, class 3 13 305
429505 AW820035 Hs 278679 a dismtegnn and metalloproteinase doma 3 13 236
446619 AU076643 Hs 313 sxreted phosphoprotein 1 (osteopondn, 3 12 255
406704 M21665 Hs 929 myosin, heavy polypepdde 7, cardix mus 3 12 554
443885 H91806 Hs 15284 ESTs 308 3 55
418203 X54942 Hs 83758 CDC28 protein kinase 2 308 220
417640 D30857 Hs 82353 protein C rxeptor, endothelial (EPCR) 306 321
447232 AW499834 Hs 327 interieukin 10 rxeptor, alpha 305 3 36
409103 AF251237 Hs 112208 XAGE-1 protein 304 207
413719 BE439580 Hs 75498 small inducible cytokine subfamily A (Cy 304 2 24
421834 BE543205 Hs 288771 DKFZP586A0522 protein 303 1 91
444666 BE293347 Hs 11638 long-chain fatty xid coenzyme A ligase 301 343
425295 AA431366 Hs 37251 ESTs 301 307
429109 AL008637 Hs 196352 neutrophil cytosolic fxtor 4 (40kD) 299 2 55
420340 NM.000734 Hs 97087 CD3Z antigen, zeta polypeptide (TιT3 com 298 598
418968 NM 000078 Hs 89538 cholesleryl ester transfer protein, plas 297 268
438914 N93892 Hs 10727 ESTs 297 2 19
418391 NM 003281 Hs 84673 troponin I, skeletal, slow 296 268
419056 M89957 Hs 89575 CD79B antigen (immunoglobulin-assxiated 296 394
449523 NM 000579 Hs 54443 chemokine (C-C motif) rxeptor 5 296 4 02
450847 NM 003155 Hs 25590 stannracalcin 1 296 3 24
418460 M26315 Hs 85258 CD8 andgen, alpha polypepdde (p32) 295 2 73
426711 AA383471 Hs 343800 coπseived gene amplified in osteosarcoma 294 2 36
426559 AB001914 Hs 170414 paired basic ammo xid cleaving system 293 2 17
424528 AW073971 Hs 238954 ESTs, Weakly similar to KIAA1204 protein 293 270
408633 AW963372 Hs 46677 PRO2000 protein 292 2 16
443195 BE148235 Hs 193063 Homo sapiens cDNA FU14201 fis clone NT 292 292
425234 AW152225 Hs 165909 ESTs, Weakly similar to I38022 hypothed 290 209
437802 AI475995 Hs 122910 ESTs 290 371
417771 AA804698 Hs 82547 rednoic xid rxeptor responder (tazao 290 3 56
438000 AI825880 Hs 5985 non-kinase Cdc42 effector protein SPEC2 290 260
414555 N98569 Hs 76422 phospholipase A2, group IIA (platelets 287 207
421958 AA357185 Hs 109918 ras homolog gene family, member H 287 348
420224 M84371 Hs 96023 CD19 antigen 286 4 77
434883 AW381538 Hs 19807 hypothetical protein MGC12959 285 544
452852 AK001972 Hs 30822 hypothedcal protein FU 11110 284 2 55
427527 AI809057 Hs 153261 immunoglobulin heavy constant mu 284 4 16
446231 NM.002163 Hs 14453 interferon consensus sequence binding pr 283 297
408838 AI669535 Hs 40369 ESTs 282 1 82
429124 AW505086 Hs 196914 minor histocompadbility antigen HA-1 282 421
425023 AW956889 Hs 154210 EDG-1 (endothelial differendadon sph 279 400
425388 AA329384 Hs 156110 immunoglobulin kappa constant 279 228
414290 AI568801 Hs 71721 ESTs 2 78 3 19
418255 AW135405 Hs 37251 ESTs 276 327
451952 AL120173 Hs 301663 ESTs 275 1 74
424865 AF011333 Hs 153563 lymphxyte andgen 75 275 3 10 409245 AA361037 tRNA isopentenylpyrophosphate transferas 274 212
453920 AI133148 Hs 36602 I fxtor (complement) 274 308
443968 AA287702 Hs 10031 KIAA0955 protein 274 234
434094 AA305599 Hs 238205 hypothedcal protein PRO2013 273 1 67
436476 AA326108 Hs 33829 bHLH protein DEC2 2 72 1 70
428398 AI249368 Hs 98558 ESTs 272 206
417141 U22662 nuclear rxeptor subfamily 1, group H, m 270 2 55
427080 AW068287 Hs 301175 ras-related C3 botulinum toxin substrate 269 3 15
442485 BE092285 Hs 29724 hypothetical protein FU13187 269 1 99
429317 AA831552 Hs 268016 Homo sapiens cDNA FLJ21243 fis.'cloπe C 269 1 70
443998 AI620661 Hs 296276 ESTs 269 230
417542 J04129 Hs 82269 progestagen-assxiated endometπal prote 268 323
414291 AI289619 Hs 13040 G protein-coupled rxeptor 86 268 301
448861 AL049951 Hs 22370 Homo sapiens mRNA, cDNA DKFZp564O0122 (f 266 251
432435 BE218886 Hs 282070 ESTs 265 3 28
430132 AA204686 Hs 234149 hypothedcal protein FU20647 265 304
427792 M63928 Hs 180841 tumor nxrosis fxtor rxeptor superfami 264 382
414696 AF002020 Hs 76918 Niemaπn-Pick disease, type C1 264 1 94
420991 AW504814 Hs 287379 Homo sapiens mRNA for FU00111 protein, 264 251
401566 NM.0 5159 Homo sapiens xdn, alpha, car 263 374
444119 R41231 Hs 184261 ESTs, Weakly similar to T26686 hypothed 263 213
425231 AA527161 ESTs 261 295
417427 M90391 Hs 82127 interieukin 16 (lymphxyte chemoattrxta 261 1 90
437669 AI358105 Hs 123164 ESTs, Weakly simila to match to ESTs AA 260 445
413856 013639 Hs 75586 cyclm D2 260 571
407928 NM 002262 Hs 41682 killer cell Ixdn- ke receptor subfami 259 268
443247 BE614387 Hs 333893 C-Myc target JP01 258 277
447131 NM 004585 Hs 17466 retinoic xid rxeptor responder (tazaro 258 928
443021 AA368546 Hs 8904 Ig superfamily protein 258 449
424779 AL046851 Hs 153053 CD37 andgen 258 388
425235 AA353113 Hs 112497 Homo sapiens cDNA FU22743 fis clone H 257 209
424265 AF173901 Hs 144287 hary/enhancer-of-split related with YRP 2 57 357
426780 BE242284 Hs 172199 adenylate cyclase 7 2 57 1 86
452721 AJ269529 Hs 301871 solute earner family 37 (glycerol-3-pho 256 290
442904 AW575008 Hs 11355 ttiymopoietm 256 339
433646 AA603319 Hs 155195 ESTs 254 219
417289 D86962 Hs 81875 growth fxtor receptor-bound protein 10 253 456
422640 M37984 Hs 118845 troponin C, slow 253 538
448413 AI745379 Hs 42911 ESTs 2 53 208
429536 AA873016 Hs 206097 oncogene TC21 252 249
446272 BE268912 Hs 14601 hematopoietic cell-spxific Lyn substrat 252 346
424378 W28020 Hs 167988 neural cell adhesion molxule 1 2 52 291
410257 BE244044 Hs 61469 hypothedcal protein 251 367
427609 AK000436 Hs 179791 hypothetical protein FLJ20429 2 51 311
424868 AI568170 Hs 96886 ESTs 251 230
418945 BE246762 Hs 89499 arxhidonate 5lιpoxygenase 250 264
420899 NM 001629 Hs 100194 axhidonate 5lιpoxygenase-xdvadng p 2 50 304
413441 AI929374 Hs 75367 Src- ke-adapter 249 237
414761 AU077228 Hs 77256 enhancer of zeste (Drosophila) homolog 2 249 1 82
429493 AL134708 Hs 145998 ESTs 249 240
419631 AW188117 popeye protein 3 248 1 85
437175 AW968078 Hs 87773 protein kinase, cAMP-dependent catalyd 248 232
421552 AF026692 Hs 105700 sxreted fnzzled-related protein 4 247 417
420158 AI791905 Hs 95549 hypothetical protein 247 262
453987 AA323750 Hs 235026 Homo sapiens, clone IMAGE 4247529, mRNA, 247 249
429640 U83508 Hs 2463 angiopoiedn 1 247 257
437330 AL353944 Hs 50115 Homo sapiens mRNA, cDNA DKFZp761 J1112 (f 246 242
426969 AI936504 CDC-like kinase 1 246 241
427674 NM.003528 Hs 2178 H2B histone family member Q 246 217
405547 NM.018833* Homo sapiens transporter 2, A 246 284
406678 U77534 gb Human clone 1A11 immunoglobulin vaπa 245 289
407013 U35637 Hs 83870 gb Human nebulm mRNA, partial eds 245 340
428746 AW503820 Hs 192861 Spi B transcnpdon fxtor (Spι-1/PU 1 r 243 6 25
453953 AW408337 Hs 36972 CD7 antigen (p41) 239 401
427759 BE245578 Hs 2200 perfonn 1 (j-ore forming protein) 239 456
443071 AL080021 Hs 8986 complement component 1, q subcomponent, 239 331
437211 AA382207 Hs 5509 ecotropic viral integradon site 2B 238 3 15
440596 H13032 Hs 103378 hypothetical protein MGC11034 237 368
452651 AI218918 Hs 30209 KIAA0854 protein 236 408
421563 NM 006433 Hs 105806 granulysin 234 325
421924 BE514514 Hs 109606 coronin xt -binding protein, 1A 233 338
449092 U91641 alpha2,8-sιalyltraιsferase 2 32 353
425367 BE271188 Hs 155975 protein tyrosine phosphatase receptor t 232 702
418117 AI922013 Hs 83496 linker for xdvadon of T cells 230 356
425795 AJ000479 Hs 159543 EDG-6 (endothelial differentiation, G-p 226 342
428111 S76617 Hs 2243 B lymphoid tyrosine kinase 225 369
439981 AI348408 Hs 124675 ESTs Weakly similar to T14742 hypothed 225 405
425722 AI659076 Hs 97031 hypothetical protein MGC13047 2 25 344
436648 R18656 ESTs 2 24 323
452250 BE618654 Hs 28607 hypothedcal protein A-211C6 1 2 23 308
441715 AI929453 Hs 342655 Homo sapiens cDNA FU13289 fis, clone OV 2 23 330
423397 NM 001838 Hs 1652 chemokine (C-C modf) rxeptor 7 222 325
449626 AA774247 Hs 301637 zinc finger protein 258 2 21 314 412975 T70956 Hs 75106 clustenn (complement lysis inhibitor, S 218 341
418739 AA310964 Hs 88012 SHP2 interxdng transmembrane adaptor 2 15 362
418185 AW958272 Hs 347326 intercellular adhesion molxule 2 (ICAM 209 521
436420 AA443966 Hs 31595 ESTs 207 381
418174 L20688 Hs 83656 Rho GDP diss∞iadon inhibitor (GDI) bet 205 3 14
420626 AF043722 Hs 99491 RAS guanyl releasing protein 2 (calcium 201 442
428289 M26301 Hs 2253 complement component 2 200 333
429683 AF148213 Hs 211604 a dis tegπn-like and metalloprotease ( 200 375
421445 AA913059 Hs 104433 Homo sapiens, done IMAGE 4054868, mRNA 1 96 368
450300 AL041440 Hs 58210 ESTs, Highly simila to ITH4.HUMAN INTER 1 91 484
416445 AL043004 Hs 79337 KIAA0135 protein 1 91 341
409817 BE295464 Hs 56607 Williams-Beuren syndrome chromosome regi 1 87 353
416967 BE616731 Hs 80645 interferon regulatory fxtor 1 1 86 355
437740 AA810265 Hs 122915 ESTs 1 86 379
437938 AI950087 gb wq05c02 x1 NCI_CGAP_Kid12 Homo sapien 1 83 342
425240 AA306495 Hs 1869 phosphoglucomutase 1 1 83 375
406972 M32053 gb Human H19 RNA gene, complete eds 1 80 403
430378 Z29572 Hs 2556 tumor nxrosis fxtor rxeptor superfami 1 78 353
437470 AL390147 Hs 134742 hypothedcal protein OKFZp547D065 1 78 339
416350 AF188625 Hs 189507 phospholipase A2, group HD 1 78 548
417852 AJ250562 Hs 82749 transmembrane 4 superfamily member 2 1 78 488
414682 AL021154 Hs 76884 inhibitor of DNA binding 3, dominant neg 1 77 579
444090 S69115 Hs 10306 natural killer cell group 7 sequence 1 74 341
427278 AL031428 Hs 174174 KIAA0601 protein 1 74 380
418618 U66097 Hs 86724 GTP cyclohydrolase 1 (dopa-responsive dy 1 73 421
420397 NM 007018 Hs 97437 centrosomal protem 1 1 73 321
418678 NM 001327 Hs 167379 cancer/tesbs andgen (NY-ESO-1) 1 3 377
459245 BE242623 Hs 31939 manic fringe (Drosophila) homolog 1 72 3 12
425356 BE244879 Hs 155939 inositol polyphosphate-5phosphatase, 14 1 71 355
423984 AF163825 Hs 136713 pre-B lymphxyte gene 3 1 70 770
422355 AW403724 Hs 300697 coagulation fxtor VII (serum prothrombi 1 70 3 10
451579 AW607731 Hs 26670 Human PAC clone RP3-515N1 from 22q11 2-q 1 68 4 19
451287 AK002158 Hs 26194 likely homolog of mouse immuπity-assxia 1 68 576
416819 U77735 Hs 80205 pιm-2 oncogene 1 67 3 17
409896 AW205479 Hs 279780 NY-REN-18 andgen 1 67 3 74
447532 AK000614 Hs 18791 hypothedcal protein FU20607 1 66 362
426666 AW500131 Hs 171763 CD22 antigen 1 65 467
412265 AA101325 Hs 86154 hypothedcal protein FLJ12457 1 65 343
416971 R34657 Hs 80658 uncoupling protein 2 (mitxhondπal, pro 1 64 366
430449 AA352723 Hs 241471 RNB6 1 62 309
424661 M29551 Hs 151531 protein phosphatase 3 (formeriy 2B) cat 1 61 3 37
453027 AI879341 Hs 539 πbosomal protein S29 1 61 11 60
410068 AI633888 Hs 58435 FYN binding protem (FYB-120/130) 1 60 328
440446 NM 013385 Hs 7189 pteckstπn homology, Sx7 and cαled/coi 1 59 3 14
453657 W23237 Hs 296162 AD037 protein 1 59 312
418102 R58958 Hs 26608 hypothetical protein MGC15880 1 58 355
424614 X54486 Hs 151242 senne (or cyste e) proteinase inhibito 1 58 307
406791 AI220684 Hs 347939 hemoglobin, alpha 2 1 55 506
421703 AI936513 Hs 1416 Fc fragment of IgE, low affinity II, rx 1 53 359
421859 AA356620 Hs 108947 KIAA0050 gene product 1 52 341
416783 AA206186 Hs 79889 monxyte to mxrophage differendadon-a 1 52 328
456086 AL161999 Hs 77324 eukaryotic transladon termiπadon fxto 1 47 334
425783 AI026740 Hs 1948 nbosomal protein S21 1 46 495
407682 AL035858 Hs 3807 FXYD domain-containing ion transport reg 1 46 348
409169 F00991 Hs 50889 (clone PWHLC2-24) myosin light chan 2 1 45 325
435624 AF218942 Hs 24889 formin 2 1 45 311
413969 X14034 Hs 75648 phospholipase C, gamma 2 (phosphaddylm 1 45 333
426530 U24578 Hs 278625 complement component 4A 1 44 427
425928 S55736 Hs 238852 ESTs, Weakly similar to hypothedcal pro 1 44 365
418219 AA731836 Hs 137319 ESTs 1 43 401
429071 AW794126 Hs 195453 nbosomal protein S27 (metallopansdmuli 1 41 423
418473 AA243335 Hs 309943 nuclear body protein Sp140 1 41 329
423766 AA303799 Hs 300141 πbosomal protein L39 1 40 3 22
430150 L05148 Hs 234569 zeta-cham (TCR) assxiated protein kina 1 39 329
416370 N90470 Hs 203697 CD38 andgen (p45) 1 36 308
406758 AA552326 Hs 77039 ATP synthase, H transporting, mitxhondr 1 32 329
448610 NM 006157 Hs 21602 nel (chιcken)-lιke 1 1 31 385
444674 BE562200 Hs 244 ammo-terminal enhancer of split 1 30 3 10
407694 U77594 Hs 37682 retinoic xid rxeptor responder (tazaro 1 30 391
427349 AA360154 Hs 177415 Finkel-Biskis-Reilly munne sarcoma viru 1 28 359
419032 W81330 Hs 99877 ESTs, Highly similar to JAK3B (H sapiens 1 28 3 21
436553 AW407157 Hs 8997 immunoglobulin lambda Ixus 1 27 400
415138 C18356 Hs 295944 dssue fxtor pathway inhibitor 2 1 24 3 25
406623 X69392 πbosomal protein L26 1 24 331
437895 A8014568 Hs 5898 KIAA0668 protein 1 21 333
421143 AB024536 Hs 102171 immunoglobulin superfamily containing le 1 18 335
TABLE 53B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Accession Genbank axession numbers
Pkey CAT Number Accession 441623 3362.1 BC022413 BE395396 BF754175 AA506621 BE7066658E706678 AA723159 BE153169 BE706729 BE706558 BE153312 BE706706 AW371853 AW371849 BE153241 BC017410 AI337912 AI090244 AW090300 BE219837 AI623661 BE501576 BE501734 AI742232 AI023964 AI458424 AA975373 AI288904 AI984583 AA890325 N32562 AI358102 AW241694 AI038448 AI672071 AI018389 AA576391 AA977874 AW189392 W37448 AA612894 AI277548 H89551 AI699774 H89365 AA315805 AW579186 BC014584 BC014581 AW780125 AI672414 BE328145 AW600919 BF031306 AW172758 8E708322 AA345675 BE875779 H28241 H25318 BF540913 BG179688 BF110202 AA528775 W37573 BE041644 AW3665048M129522 BM129822 AI122760 BE718200 AW887496 AA149420 BE706307 BE539395 BE748765 AI373653 R75904 BF979185 BF691393 BG495595 BI094458 BE706702 BG496559 BF248373 BG494800
416373 3442.1 AK056582 AW755252 AL596757 BF827376 BF827373 BF827375 BF827369 BF826900 F01252 BC022888 BI850312 AA195845 BF825671 BF574821 Z21696 F32854 AA211780 F21569 AI288453 AI803678 AA180309 AI074627 AA192950 AA661688 F36698 F32290 F28773 F22692 AA424993 AW340328 AA192247 BF672229 BF575143 BF673106 BF693623 433470 6624.1 X75684 AL573167 AI445461 AI453743 AI983655 AI564644 AA977180 A1694111 AI591358 AW071625 AI678712 AI720939 A1927769 BE439796 AI963432 AA292956 AW192593 AI865838 AI696905 AI424384 AI161312 AI911921 AI597801 BI494959 AI240988 AI492554 AW262737 BE044033 AW008570 AW629505 BI494958 AA088439 AA706057 BF222820 BF593608 BE501957 AA524526 BE044134 AW572531 AW015724 BE349186 AA043217 BE219784 AI799814 AA129575 AI671727 AI470033 BE646195 AW779725 AA903050 AA147228 AA404570 AI075878 W38161 AI972739 AW673152 AA723200 C06123 BF057147 AA627686 AA157944 AI990245 AA662517 T32487 AI80O106 AI333170 AI859160 W45410 AI990827 AW275048 AA182640 AA478328 AI298935 AW085158 AW471421 AW103470 AW300456 AW191997 AI823466 AA962397 AA136658 AI251817 AW339104 AA724739 AA411100 AA191349 AA757735 AA037696 AI769516 AW772283 AA010631 AI692846 AI061065 H80983 R79933 AI950693 AI245632 AI349390 AA148284 AI798502 AA487893 AI621320 AW194272 C06365 AA953883 BE858936 AI918523 AI872628 AI927217 AI453453 AI189366 AW338678 AI261359 AI500576 BF477735 AI032569 AI972899 AI985583 Z28771 AI363829 AI693030 AA603586 BE773488 AW339301 BE773489 BE773462 BE773495 AI650338 BE773499 AI745717 BE811475 BE811470 BE811464 BE811418 BE811415 BE811400 BE811398 BE811388 BE811352 BE773501 BE773494 BE773486 BE773474 BE773473 BE773470 BE773461 BE811350 BE811337 BF593847 BG055071 AW675302 BF003068 AA719173 BE811348 AI582462 AI686240 BE773500 AI244845 AI565439 AI918453 AI472527 AI446740 AA035576 AA191414 AW674145 C05782 AI589264 D57558 AI468237 AI432033 AA989662 R21752 BF002457 AA988297 AL574095 AL576200 AL571074 AL574525 AL578810 BG498381 AI928364 BE879732 AA479834 AA479712 C17732 BM091258 BF843901 AW820230 C17476 BE327120 AA129574 AA136645 BF843900 AW806193 AA502832 AA649494 AL568520 AL547960 BE706937 BE811360 BE773498 BE811401 BE773484 BE811437 BE811380 BE811399 BF997171 BF757734 BE926037 AI377596 C06111 AW088968 BE811404 BE811472 AI865912 AI925607 AI871950 AI093510 BE905927 BE811435 AA191387 AW772000 BE811453 BE614379 BF844522 BI044896 AI744233 AW984527 C17504 BF843883 AI248307 BE773483 AI567995 W60075 BF941183 AI738844 BE811458 BE773481 AI262930 AA948565 BE706942 BE156360 T65026 AW242958 AW197954 BE905184 AA722206 AI344943 AI348877 AI3348608E621857 BE156280 AA454099 AA037722 BF843897 AW806183 AA043216 BG482896 AA182734 AA877242 AW372926 H27252 R38114 BF851858 BE156214 AA190427 T91762 AA035067 AA837326 T10930 BF906587 BI755027 BG506731 BC008442 BC010166 AL550134 AL553096 AL548700 AL550751 AL547978 AL545286 AL540643 AU118627 AL601379 BI259821 BG741786 BI868522 AU135866 BI552770 BI259210 BI256520 BI255569 BG485098 BI258228 BG498501 BM044512 AU133984 AL556586 BE745111 BI222633 AU133917 BG288151 BI260715 BI550550 BG500773 BI551761 BG707601 BI818593 BF691383 BG721129 BG541578 BE906666 BG751098 BI224135 BG400746 BG478065 BE790436 AW080238 AU137549 BG429896 BE392486 AW961686 BG7210568E908365 BE546656 BG541235 AW583735 BG528290 BI260895 AW651691 BM048974 BM043805 BG142185 AA315188 AI446615 C06300 BG497644 AA088544 AI815987 BG528631 BE619182 AW239185 AW062910 AW062902 AA347236 F11933 AA488005 AA301631 AA376800 D56120 AA343532 AA308636 F00242 AA376086 AA316968 AA343799 BI870221 BE910282 BG538748 AW960564 AV732879 D16854 AA192519 BF922148 AA216013 BG624091 BE544387 BG507008 AW176446 BF790033 BE088925 BE088854 AA921353 R21800 AA011222 T97525
409245 3199.2 AF030234 BC017465 BG008526 AW505550 BM460141 N47324 AA361037 AA321632 N45606 AV752798 AV657116 AA296632 AU137857 AW467027 AI742080 AI624350 H58206 AA478518 AW439997 AW393555 AW393523 AI559753 AI808732 R66856 H01374 BI257369 BI259830 AW960845 BM466252 AW956813 BE768647 AV658853 BM055248 BF372070 BF372055 BF372061 AA347852 AA905863 BG505078 AV654024 BF093291 AW021929 H22650 AA459715 BG496341 BE697763 BI254209 BG499543 H42946 BI059780 BI086741 H87896 H87599 BF691752 BE768511 BG940948 W37195 BF372041 BE883796 BF372082 BF367329 BF909744 AW966003 AV714014 BI492868 BI495144 AA921845 AI693426 AI652147 AI435449 N47325 AI434429 AA573137 AI183429 AI829962 AI332526 BF513937 AI189561 AI221962 AI378034 AW118897 AW665247 AW340077 N41605 AA478519 AA463875 AI858260 AA463379 AI292305 BE045947 AA971089 AI125820 BG940947 AI080245 AA884954 AI125702 AI382934 AA931835 AI358631 AW439905 AI027833 AI399648 AI014533 AA347851 AA738261 N67374 N69081 AI768667 AA948472 AI819214 AA293133 AI186725AA889214AI222635 BI495143 N29605 N48812 AA769041 AI492769 D56771 AA095911 BE222062 056772 AW372265 BM054985 D12465 BG534562 AW003511 H87486 H42880 AW190293 BF594697 BF377611 H22043 BI255749 BI492848 H16217 H21980 H22651 H88179 H87354 H44052 H25165 H44128
417141 9517.1 AI391712 U22662 NM.005693 AW166878 BF339795 AI970974 AI521157 AI336082 AW339789 AI288682 BF477594 BF477593 AI703008 AI290961 AI049684 AW770753 AI208561 AI699406 F33996 AA630563 AI985346 AI927058 AA533982 AW204589 AI206938 AW590068 AI263769 AA991550 AI192005 AL558946 AL524337 AL516239 AL580848 AL580658 AI719135 AW026500 AI698217 AI872977 AI670983 AI654870 AA493407 AA548525 AI016420 AA843563 W15576 H61726 AA913245 BF438146 AL524338 BI762380 AU136488 BI759892 AV655930 T78977 BI524075 BE538944
425231 235504.1 AA527161 BG211784 AA527065 AA505489 AW512550 419631 2743.1 BC022323 AF204171 NM.022361 BM264431 BE670789 AW188117 AI025298 AA861832 H84897 AI382294 AA662874 AW993380 BE813742 H84368 AI188074 N20482 H84369
426969 121131 M59287 AI936504 AI694705 AI679216 AI679235 BF110184 AW518110 AI679811 AW054981 BE465531 BE327409 AW339105 BI714787 AI871568 AW129115 AU145080 AI223299 AW129986 AA780771 BG654629 AU144657 BF437422 AI478374 AA492513 AU157562 AI826962 AU145528 AI951093 AW513819 AA042856 AA725690 AA733176 AI028702 AI251890 AI811729 AW975208 AW339589 AI147868 AU157862 AA629327 BF476670 BE464796 AW510511 AA399098 AA398210 Al 291998 AI160296 AU158075 N34811 BE326407 AI270552 AA496923 AA508002 AI270284 AI139504 BF437009 AI354626 AI936336 AA287250 AA491855 BF445818 AA688026 AA284510 AW151564 AA412072 AA709241 H89332 BF445769 BF989466 BF989472 AA631105 Al 129915 W96362 AA515277 AA541513 L29222 AV758119082109 AL040956 BE244413 AV645640 BE246321 BE246314 D82116 AL036176 AA331779 AU100106 BE243857 AU076865 AW972327 AA497087 AI687039 AW072798 AI174455 AU156788 AA044401 AA046086 BE244986 AI634456 BE242945 8E242089 AU156034 BE244982 AL567955 BI005141 AA040426 AW630506 BF155668 AU118544 BG573573 W96436 AA373395 BE710347 AL564154 AI708332 AA729530 N92729 AI573015 T29655 H89333 H85847 AI885473 AW189980 H02905 AI811986 AU157753 W86829 AA020844 AU158204 AA057356 AA283466 AA405504 AA017027 W94754 AA226498 W72391 H66461 C0O442 H01925 BI912232
406678 00 U77534 U77537 449092 4406.1 AK056270 AV706896 AI692935 AI681140 AW162481 AW087114 AW157019 AI689795 AW251085 AW206911 BF438207 AW134945 BE041668 BF111425 U91641 NM 013305 BF968902 U55966 AU130750 BE174853 AI929731 AW161524 R43753 BE779688
436648 52977.1 AJ002788 AL118656 AF381600 BE672862 AW500520 BF223709 AW593740 AA262174 AA810597 AA810596 AA810595 F09382 BF976590 AW968002 AA262288 BF931698 AW968014 R18656 BM459356 AW794189 BF954184 Z42558 BF891641 BF963380 Z45874 F05187 X93079 BF742651 BF742649 R51324 D80031 BI457883 F06613 Z43128 F122438F950830 H19040 BF950829 F06439 R14947 F06702 R61037 R52173 R14953 R12174 R13610 H10426 R11851 T65264 R18737
437938 66997.1 U71456 AA482911 W78802 AW856538 BF737212 N36809 N35320 AA282915 AW505512 AI653832 W87891 AI961530 T85904 H59397 R97278 W01059 AI820532 T82391 AI820501 T63226 R66056 R67840 AW961101 AA337499 W37181 AA18O009 AW205862 AA988777 AA856975 BF172457 BG751124 AI741346 AI950344 AI689062 AI872193 AW102898 AW173586 AI763273 AI890387 AW150329 AI762688 AA488892 AI356394 AI539642 AA642789 AI950087 BF589902 N70208 AA283144 AA488964 H60052 R97040 BF886630 AW967677 AW971573 AW967671 AI308119 AA251875 AA908598 AI819225 AI564269 AA908741 AA293273 AA969759 AW276905 AA044209 H83488 T92487
406623 0.0 X69392 T24055
TABLE 53C Pkey Unique number corresponding to an Eos probeset Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publicadon entitled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495 Strand Indicates DNA strand from which exons were predicted
NLposidon Indicates nucleotide positions of predicted exons
Pkey Ref Strand NLposidon
405545 1054740 Plus 118677-118807,119091-119296,12162512182
401566 8469090 Minus 96277-96420,96979-97160
405547 1054740 Plus 124361-124520,124914-125050
TABLE 54A ABOUT 161 GENES UPREGULATED IN PRIMARY MELANOMAS FROM TUMORS THAT LATER METASTASIZED RELATIVE TO PRIMARY MELANOMAS THAT DID NOT METASTASIZE LATER
Table 54A lists about 161 genes upregulated in pnmaiy melanomas from tumors that later metastasized reladve to pπmary melanomas that did not metastasize later These genes were selxted from 59680 probesets on the Eos/Affymetnx Hu03 Genxhip array Gene expression data for exh probeset obtained from this analysis was expressed as average intensify (Al), a normalized value reflxdng the reladve level of mRNA expression
Pkey Unique Eos probeset idendfier number
ExAxn Exempla Axession number, Genbank accession number
UnigenelD Unigene number
Unigene Tide Unigene gene dtle
R1 90th percendle of Als for pπmary melanomas that later metastasized divided by the 90th percendle of Als I
R2 90th percendle of Als for pπmary melanomas that later metastasized divided by the 90th percendle of Als I where the 15th percendle of normal dssue Als was subtrxted from both the numerator and denominator
Pkey ExAxn UnigenelD Unigene Tide R1 R2
448966 AW372914 Hs 86149 phosphoinositol 3-phosphate-bιndιng prot 7 15 341
413916 N49813 Hs 75615 apolipoprotein Oil 593 655
414807 AI738616 Hs 77348 hydroxyprostaglandin dehydrogenase 15(N 564 298
415668 AW957684 Hs 306814 hypothedcal protein FU21889 503 456
440274 R24595 Hs 122 scrapie responsive protein 1 498 483
417542 J04129 Hs 82269 progestagen-assxiated endometπal prote 496 707
427882 AA640987 Hs 193767 ESTs 468 468
452744 AI267652 Hs 246107 Homo sapiens mRNA cDNA DKFZp434E082 (fr 429 306
407907 AI752235 Hs 41270 procollagen-lysme, 2-oxoglutarate 5dιo 394 386
424410 W79027 Hs 271762 ESTs 367 3 19
429083 Y09397 Hs 227817 BCL2-related protem A1 346 249
407951 W77762 Hs 79015 andgen identified by monoclonal anbbod 331 306
428330 L22524 Hs 2256 matπx metalloproteinase 7 (matπlysm, 327 2 12
440099 AL080058 Hs 6909 DKFZP564G202 protein 322 269
428001 H97428 Hs 219907 ESTs, Moderately similar to Transforming 320 1 85
451099 R52795 Hs 25954 interieukin 13 rxeptor, alpha 2 3 18 461
442432 BE093589 Hs 38178 hypothetical protein FU23468 3 13 2 11
430643 AW970065 Hs 287425 MEGF10 protein 3 10 331
412262 W26406 seven in absenda (Drosophila) homolog 1 306 394
438328 AI492261 Hs 32450 ESTs 305 309
409760 AA302840 gb EST10534 Adipose dssue, white I Homo 301 265
453912 AL121031 SWI/SNF related, matπx assxiated, xd 294 1 86
416426 AA180256 Hs 210473 Homo sapiens cDNA FU14872 fis, clone PL 291 370
407744 AB020629 Hs 38095 ATP binding cassette, sub-family A (ABC1 288 253
453935 AI633770 Hs 42572 ESTs 288 200
452689 F33868 Hs 284176 transfemn 284 647
449550 AA353125 Hs 184721 ESTs 283 474
409417 AA156247 Hs 104879 senne (or cysteine) proteinase inhibito 282 243
438898 AI819863 Hs 106243 ESTs 281 208
430191 AI149880 Hs 188809 ESTs 280 269
408418 AW963897 Hs 44743 KIAA1435 protein 279 1 75
450157 AW961576 Hs 60178 ESTs 277 340
420380 AA640891 Hs 102406 ESTs 277 4 28
443172 AW662964 Hs 199061 p30O/CBP-assxιated fxtor 275 288
456629 AW891965 histone dexetylase 3 272 2 24
407857 AI928445 Hs 92254 synaptotagmin-like 2 272 1 93
421097 AI280112 Hs 125232 Homo sapiens cDNA FU 13266 fis, clone OV 268 259
436280 AI690734 Homo sapiens cDNA FU22562 fis, clone H 267 279
407550 Y10515 gb H sapiens mRNA for CD58 T7 protein 265 1 98
427871 AW992405 Hs 59622 Homo sapiens, clone IMAGE 3507281, mRNA, 264 1 76
427899 AA829286 Hs 332053 serum amyloid A1 2 59 301
442793 AI017798 ESTs, Weakly similar to TI47.HUMAN CARGO 258 1 60
446619 AU076643 Hs 313 sxreted phosphoprotein 1 (osteopondn, 257 1 91
444381 BE387335 Hs 283713 ESTs, Weakly similar to S64054 hypothed 2 57 2 13
458247 R14439 Hs 209194 ESTs 256 261
451668 Z43948 Hs 326444 cartilage acidic protein 1 252 274
433980 AA137152 Hs 286049 phosphosenne aminotransferase 251 1 88
412719 AW016610 Hs 816 ESTs 250 1 68
441789 D52059 Hs 7972 KIAA0871 protein 250 3 11
405885 Target Exon 250 3 15
453464 AI884911 Hs 32989 receptor (calcitonin) xdvity modifying 248 333
417821 BE245149 Hs 82643 protein tyrosine kinase 9 248 1 66
450202 AW969756 Hs 34145 ESTs Weakly similar to B49647 GTP-bindi 247 279
436825 AW341123 Hs 120275 ESTs 247 255
424762 AU 19442 Hs 183684 eukaryotic translation initiation fxtor 242 2 28
432426 AW973152 Hs 31050 ESTs 242 1 76
409095 AW337272 Hs 293656 ESTs, Moderately similar to S72481 proba 241 241
403752 NM.002753" Homo sapiens mitogen-xdvate 241 287 404489 Target Exon 239 1 97
411690 AA669253 RNA, U2 small nuclear 2 37 254
439195 H89360 gb yw28d08 s1 Morton Fetal C∞hlea Homo 237 227
453582 AW854339 Hs 33476 hypothedcal protein FU 11937 2 36 281
438461 AW075485 Hs 286049 phosphosenne aminotransferase 235 291
432878 BE386490 Hs 279663 Pinn 235 228
416647 BE297139 Hs 79411 replicadon protein A2 (32kD) 233 1 97
428666 AL080190 Hs 189242 Homo sapiens mRNA, cDNA DKFZp434A202 (fr 232 292
413645 AA130992 gb zo15e02 s1 Stratagene ∞lon (937204) 231 263
421282 AA286914 Hs 40782 ESTs 2 31 1 85
434418 AF134707 HS 278679 a dismtegnn and metalloproteinase doma 231 2 21
413204 BE071603 gb QV3-BT0510-161299-032-f03 BT0510 Homo 231 1 49
449720 AA311152 HS 288708 hypothedcal protein FU21562 230 1 78
451838 AW005866 Hs 193969 ESTs 228 205
410943 AW968322 Hs 11156 low molecular mass ubiquinone-binding pr 228 239
459711 BE386801 Hs 21858 tnnucleofide repeat containing 3 227 239
429489 AF008203 Hs 204039 anstaless-like homxbox 3 2 26 1 97
429493 AL134708 Hs 145998 ESTs 226 277
422283 AW411307 Hs 114311 CDC45 (cell division cycle 45, S cerevis 226 1 78
441989 AA306207 Hs 286241 protein kinase, cAMP-dependent regulato 226 1 84
419352 AI675008 Hs 199493 ESTs 225 1 47
427393 AB029018 Hs 177635 KIAA1095 protein 225 1 83
418522 AA605038 Hs 7149 Homo sapiens cDNA FU21950 fis, clone H 224 242
433468 AA832055 Hs 172843 ESTs, Weakly simila to ALU1 HUMAN ALU S 224 1 76
452782 AA028166 Hs 17733 ESTs 224 234
443910 AW051711 Hs 132440 ESTs 224 1 9
408832 AW085690 Hs 63428 ESTs, Weakly simila to Z195.HUMAN ZINC 2 22 1 52
407283 T51008 gb yb55e08 s1 Stratagene ovary (937217) 222 1 31
437376 AA749400 Hs 257890 ESTs 222 244
450712 AI732130 Hs 270496 ESTs, Weakly simila to ALUB.HUMAN «» 222 1 62
421362 AK000050 Hs 103853 hypothedcal protein FU20043 222 236
445183 AB007877 Hs 12385 KIAA0417 gene product 220 1 84
438501 Z44110 Hs 86149 phosphoinositol 3-phosphate-bιndιng prot 220 1 76
432882 NM 013257 Hs 279696 senim/glucocorticoid regulated kinase Ii 219 1 59
414900 AW452420 Hs 248678 ESTs 2 18 1 89
427704 AW971063 Hs 292882 ESTs 217 1 86
404942 splicing fxtor, agmine/seπne-nch 9 217 1 86
448019 AW947164 Hs 195641 ESTs, Moderately similar to I38022 hypot 217 1 64
459254 AA694386 Hs 290914 ESTs 2 16 1 61
418965 AI002238 Hs 11482 splicing fxtor, argmine/seπne-nch 11 216 1 79
443357 AW016773 low molecular mass ubiquinone-binding pr 216 232
412432 AA126311 Hs 9879 ESTs 2 15 273
449567 AI990790 Hs 188614 ESTs 208 285
433179 AW362945 Hs 162459 ESTs 207 477
408243 Y00787 Hs 624 interieukin 8 205 3 12
435294 T84084 Hs 196008 Homo sapiens cDNA FU11723 fis clone HE 1 97 289
449656 AA002008 Hs 188633 ESTs 1 94 360
412649 NM 002206 Hs 74369 integnn, alpha 7 1 93 276
445162 ABθ"il131 Hs 12376 pic∞to (presynapdc cytomatnx protein) 1 93 266
419356 AI656166 Hs 7331 hypothedcal protem FU22316 1 92 339
424263 M77640 Hs 1757 L1 cell adhesion molxule (hydrxephalus 1 89 3 10
414694 NM 015362 Hs 76907 HSPC002 protein 188 425
415825 Y18024 Hs 78877 inositol 1,4,5tπsphosphate 3-kιnase B 1 87 266
409105 AW467539 Hs 255877 ESTs 1 87 296
444784 D12485 Hs 11951 xtonucleodde pyrophosphatase/phosphodi 1 85 2 80
404149 C6002509' gι|5031885|ref|NP_005568 1| Ii 1 84 293
406387 Taiget Exon 1 82 296
420871 AA702972 Hs 65300 ESTs 1 76 312
455797 BE091833 gb IL2-BT0731-260400-075F04 BT0731 Homo 1 75 3 12
418751 BE389014 phosphoιnosιtιde-3-kιnase, regulatory su 1 70 320
412347 AW970026 Hs 73818 ubiqumol-cytxhrome c reductase hmge p 1 67 365
413211 AW967107 Hs 109274 hypothedcal protein MGC4365 166 289
459317 BRCAIb Eos Control 1 61 734
425525 AA358883 Hs 23871 ESTs 1 59 267
436823 AW749865 Hs 117077 ESTs, Weakly simila to 138022 hypothed 1 56 276
433669 AL047879 Hs 194251 ESTs, Weakly simila to ALU2.HUMAN ALU S 1 55 276
424389 AA339786 lymphxyte-spxific protein 1 1 53 295
426672 AW270555 Hs 171774 hypothedcal protein 1 51 3 39
415977 AL037622 Hs 78935 methionine aminopepddase, elF-2-assxιa 1 47 265
404780 Target Exon 1 43 2 77
436476 AA326108 , Hs 33829 bHLH protein DEC2 1 1 304
428284 AA535762 Hs 183435 NM.004545 Homo sapiens NADH dehydrogenas 1 38 294
448571 AA486794 Hs 66915 ESTs, Weakly simila to 167Kd protein ( 1 37 280
428156 BE269388 Hs 182698 mitxhondnal πbosomal protein L20 1 36 329
447752 M73700 Hs 105938 Ixtotransfemn 1 5 270
447455 H38335 Hs 6750 Homo sapiens mRNA for FU00058 protein, 1 35 303
453281 W46280 Hs 55940 ESTs, Weakly similar to A25704 syπapsm 1 34 269
413142 M81740 Hs 75212 ornithine dxarboxylase 1 1 33 296
407194 AA621644 gb af54a01 s1 Soares otal_fetus_Nb2HF8_ 1 32 270
444107 T46839 HS 10319 UDP gly∞syltransferase 2 family, polype 1 26 327
406797 AI432224 πbosomal protein L6 1 26 2 72
406711 N25514 HS 77385 myosin, light polypepdde 6, alkali, smo 1 25 7 10
414608 BE396215 Hs 76572 ATP synthase, H transporting, mit hondr 1 24 272 401846 NM.000988* Homo sapiens nbosomal protei 1 24 282
432982 AA531058 Hs 182248 truncated calcium binding protein 1 23 3 10
428578 BE391797 Hs 343588 πbosomal protein S12 1 23 274
400199 Eos Control 1 21 358
400079 Eos Control 1 20 299
412623 R28898 Hs 74170 metallothionem 1E (functional) 1 19 263
406713 U02629 Hs 77385 myosin, light polypepdde 6 alkali, smo 1 19 4 15
406712 M31212 Hs 77385 myosin light polypepdde 6, alkali, smo 1 18 475
442492 AA528489 Hs 234518 πbosomal protein L23 1 17 274
431526 Y10129 Hs 258742 myosm-bindiπg protein C, cardix 1 17 315
436398 H87136 Hs 5174 πbosomal protein S17 1 16 322
432205 AI806583 Hs 125291 ESTs 1 15 276
406859 AI581134 Hs 181357 laminin rxeptor 1 (67kD, πbosomal prot 1 09 266
401254 Target Exon 1 00 308
405752 Target Exon 1 00 287
445772 AI733941 Hs 145493 ESTs, Weakly similar to ALU7.HUMAN ALU S 100 270
452916 AA642831 Hs 31016 putadve DNA binding protein 1 00 262
451411 AA01 492 Hs 135655 EST 1 00 264
415658 BE501921 Hs 270471 ESTs 1 00 282
448610 NM 006157 Hs 21602 nel (chιcken)-lιke 1 1 00 330
TABLE 54B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Axession Genbank axession numbers
Pkey CAT Number Accession
412262 4362.1 AK056051 AI971258 AI681134 AU146134 AI803300 AA917325 AA923663 BF895068 AI304442
T90930 AI886230 U70056 AU119916 BF446537 BE503207 BE502849 AI698102 AA258553 AV718529 AV719917 BF724133 BI438668 AI804000
BE349103 AI912294 BE645117 AA227954 AA446520 AA879147 AA281770 AW136872 AA807907 AI435989 AI339626 AI383274 AA418512 BE771804
BF894509 AA455093 AI379061 AI150855 BF769906 R17298 AU138740 BF808607 BE674633 AV700132 AA227789 AA253099 AW975199 AA935418
T74315 F12666 AA022923 T89028 AA258606 W26406 BE838620 AV700706 AA101321 R41382 H14479 AA253044 R54810 R42784 R44804 R41278
409760 865166.1 AA302840 T93016 T92950 AU184997 AA077551 453912 32562.3 BM472224 BI966849 BI966735 AW973032 BI962894 BI963048 AA548765 AI926504 AA041551 AW043754 AI086702 AW008105 AA974849 AW614893
AA553737 AA916996 AW262982 AI580991 BF726843 AV693312 W35325 AA039927 BG460936 AW388482 AW388420 BF374777 W01360 N94710
H87967
456629 207.22 AW891965 AW604749 BE080872 R15559 BE177623 AW883520 AW945343 AI246167 T07082 AW805679 W96278 AA135796 W32615 AW995418
AW801688 BE003837 AW801621 AW385721 AW385742 AW385714 AW604757 W87409 AW604738 AW385757 AW580796 AW801247 BE003239
BE0O3183 AA847112 AW580975 AW604760 AW385727 BE164590 BE003090 AW362791 AW604759 AW866589 AW604758 N44337 AI378548
AW890438 AA077172 AI288683 AA229639 AA091945 AW945454 AA063629 AA702504 AW861938 AW894816 AW580841 AA094372 T06399
AW885686 BE244086 BE005035 AW861913 AA551773 AW858460 AW370926 AW754352 AW889695 AW384408 AI907428 BE067491 AW861939
AA248197 AW381373 AW177325 AW806879 AA935217 BE067498 BE083742 BE067470 AW894935 BE082529 AI248811 BE179917 BE002200
AW607506 AW392889 AW894560 AW381360 AI904206 AW863533 C00609 AW381372 BE082530 AW898120 BE075323 AW392799 AW601420
AI695314 BE083790 AW858568 AW945550 BE177153 AW970506 BE350419 AI906919 AW360794 AI906917 AW885979 AW794240 AW945566
AI688683 AI688694 AW009660 AW601421 AW3607938E066524 BE083901 AW369847 AW381871 AW935435 AW664582 AW877775 AW838449
BE180466 AW858501 BE180464 AI371163 AA778231 AI174991 BE011720 AW877776 AW877800 AW877795 T19900 AW866365 AW898099
BE011715 BE167842 BE011718 BE011724 AW363639 AW878658 AW878662 AW894887 BE082356 AW389211 AW804286 AW610312 AI904717
AW610318 AW996909 AW610296 AW901923 AW880003 AI762171 AW062582 AW368713 AW062593 AW176663 AW842064 AW842089 AW842095
AI243049 AW902074 AW062592 AW176664 AW751692 BE087703 AI907439 BE009686 BE172115 BE077030 AW608556 AW835577 AI909628
BE077029 AW176241 BE077552 BE160370 BE160288 AW835656 AW606765 AW606770 AW835678 AW606758 AW606778 AI907484 BE172821
AW606768AW999517 AW844165 BE171738 AW751683AW610493 BE177484 BE177487 AA090510 AW844117 BE173367 AW999878 AI124870
BE163472 AW841823 AW379762 AW893297 AI290296 BE089132 AA610287 AW176676 AW607622 BE172639 AW893232 AA329629 BE0890O8
BE178350 BE178214 BE063291 AW820236 AW999653 BE089486 BE173126 BE171775 BE185787 AA558280 AI174840 AW999112 BE218391
BE172734 BE178021 BE172738 BE173324 AW603494AL036722 R38192 R60905 H53721 H41052 AL037917 R37795AW998972 AA767189
AW044272 H50689 AA768399 AA767764 AI087888 H44202 BE222792 N90597 W81396 N90615 AI935353 BE501168 F10945 AW118215 AI970480
AI627641 AW236081 AA574090 AI627652 AI681913 AI759983 N69591 N69276 BE467722 AW392780 BE172467 H92861 AI524921 F02989 Z39328
F02705 F0141 T88678 AI215165 H87220 AW374781
436280 36296.1 AK026215 AI201248 BE671206 AA860436 AA730787 AA834507 D79304 D79806 AW961628 AI017068 BE044373 AA322458 AA987927 AA385869
BI492783 AW021853 R79299 N73208 AI016622 N24609 AW192S69 AA707819 AI690734 R79189 AI535900 AW589301 AI128434 BE838011 BE837891
BF894555 H95408
442793 417820 2 BG741247 BG741022 AI017798 AI953594 AW445065 AI245087 411690 53926.1 AK027091 BF514593 BF768430 BI037830 BE175161 BG000114 BG897171 AA745391 AA669569 AA669253 BI049453 BE304449 BG010136
BG830874 BF091358 BF762561 T56173 BC003629 BF091330 BE697323 BF091340 BE843330 AA744150 AA745471 W26276 BI037837
439195 21979.1 AF086037 H89360 H89546 413645 1234345.1 AA130992 AW969537 AA503835 413204 1494523.1 BE071616 BE071613 BE071603 BE071587 BE071607 BE071615 BE071636 443357 427117.1 AV715934 BG654600 AI052778 BG057892 AW016773 AI452937 AW085293 455797 1511159.1 BE091833 BE091874 BE091871 418751 21393 1 BF690141 BE159368 AI937311 AU151256 AW341542 AW274231 AW341609 AW450447 AA843698 AW188066AW007171 AW007027 AI075008
AL520351 AA608992 AW151842 AA622181 AI273454 AI005661 AA205946 AA677899 AW473512 AW296620 AA872899 AI094216 AI025188 AA256998
AI539154 AI500192 AI289493 AI040740 BE167841 AW151374 BE167754 BF036108 AA299181 N23237 T62967 W96060 AA574412 AW606697
W96059 R51303 R09158 R59113 T48473 T59023 AA122066 AW606643 R38386 R06567
424389 1059.4 BG190758 AW961118 W77994 AA339877 AW845121 AW845129 BG181820 BE716719 AI125483 AI161017 W73951 AI250771 AA912611 AA339786
BE838286 BE838282 BE716636 AA777158 W94063 BE716628 BE716625 BE838371 BF371044 BE716631 BE716402 406797 0.0 AI432224 AW276890 AI499346 AA937014 AA653573 AI318525 AI246219 AA961591 AI270640
TABLE 54C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al * refers to the publication endded "The DNA sequence of human chromosome 22* Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposidon Indicates nudeodde posidons of predicted exons Pkey Ref Strand Nt posidon
405885 7677703 Minus 42574-42998
403752 7678857 Plus 33704-33828
404489 8113772 Plus 9818598480
404942 7382153 Plus 9209592252
404149 7534008 Plus 121831-121951,124044-124150
406387 9256180 Plus 116225116371,117512-117651
404780 9887810 Minus 175705175871
401846 7712190 Minus 8277582823,82912-83022
401254 9796309 Plus 152209-152383
405752 9212305 Plus 91392-91528
TABLE 55A ABOUT 201 GENES UPREGULATED IN PRIMARY MELANOMAS FROM TUMORS THAT DID NOT METASTASIZE RELATIVE TO PRIMARY MELANOMAS THAT LATER METASTASIZED
Table 55A lists about 201 genes upregulated in pπmary melanomas from tumors that did not metastasize reladve to pπmary melanomas that metastasized later Genes were selxted from 59680 probesets on the Eos/Affymetox Hu03 Genxhip array Gene expression data for exh probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflxdng the reladve level of mRNA expression Pkey Unique Eos probeset idendfier number
ExAccn Exemplar Axession number, Genbank xcession number
UnigenelD Unigene number
Unigene Tide Unigene gene dde
R1 90th percendle of Als for pπmary melanomas that did not metastasize divided by the 90th percendle of Als from pπmary melanomas that metastasized later
R2 90th percendle of Als for pπmary melanomas that did not metastasize divided by the 90th percendle of Als from pnmary melanomas that metastasized later, where the 15th percendle of normal dssue Als was subtrxted from both the numerator and denominator
Pkey ExAxn UnigenelD Unigene Title R1 R2
413554 AA319146 Hs 75426 sxretograπm II (chromogramn C) 808 548
404854 Target Exon 518 8 18
406636 L12064 gb Homo sapiens (clone WR4 12VL) and th 489 495
433435 BE545277 Hs 340959 Ts translation elongation fxtor, mitxh 483 486
408471 NM.012317 Hs 45231 leucine zipper, down-regulated in cancer 471 470
433658 L03678 Hs 156110 immunoglobulin kappa constant 471 385
412802 U41518 Hs 74602 aquaponn 1 (channel-forming integral pr 398 4 01
415801 R24219 Hs 278443 Fc fragment of IgG, low affinity lib, re 392 335
400417 X72475 Target 383 278
419870 AW403911 Hs 266175 phosphoprotein assxiated with GEMs 367 229
409190 AU076536 Hs 50984 sarcoma amplified sequence 362 368
408692 AL040127 Hs 34074 dipeptidylpeptidase VI 361 389
423619 T48691 Hs 249159 adrenergic, alpha-2A-, rxeptor 356 361
442117 AW664964 Hs 128899 ESTs, hypothedcal protein for IMAGE 447 355 285
445745 AB007924 Hs 13245 KIAA0455 gene product 338 255
406663 U24683 immunoglobulin heavy constant mu 334 616
414522 AW518944 Hs 76325 Immunoglobulin J chan 332 275
419235 AW470411 Hs 288433 neurotnmin 332 2 74
441598 AI733219 Hs 58262 ESTs 331 371
402294 Target Exon 324 235
402737 Target Exon 322 287
414135 NM.004419 Hs 2128 dual spxificity phosphatase 5 320 304
410268 AA316181 Hs 61635 six transmembrane epithelial andgen of 318 281
427335 AA448542 Hs 251677 G andgen 7B 317 462
404995 ENSP00000251890" Moπxydc leukemia zinc 313 234
430540 AW245422 Homo sapiens cDNA FLJ22105 fis, clone H 312 221
430015 AW768399 ESTs 312 1 93
414340 AI022656 Hs 296272 ESTs 309 287
400072 Eos Control 308 3 16
422567 AF111178 Hs 118407 glypican 6 306 273
401284 Target Exon 304 256
455839 BE145814 gb MRO-HT0208-101299-202-a04 HT0208 Homo 302 276
454027 R40192 Hs 21527 Human DNA sequence from clone GS1-115M3 300 3 15
437258 AL041243 Hs 174104 ESTs 299 244
445612 N94126 Hs 12969 hypothedcal protein 298 240
417777 AI823763 Hs 7055 ESTs, Weakly simila to I78885 senne/th 297 213
437723 AI672731 Hs 13256 ESTs 295 246
439668 AI091277 Hs 302634 frizzled (Drosophila) homolog 8 295 277
424321 W74048 Hs 1765 lymphxyte-spxific protein tyrosine k 294 268
424761 AA534528 Hs 152944 loss of heterozygosity 11, chromosomal 292 381
405757 Target Exon 292 300
406621 X57809 Hs 8997 immunoglobulin lambda locus 292 671
409060 AI815867 Hs 50130 nxdm (mouse) homdog 286 2 16
431712 R26584 Hs 267993 hypothedcal protein FU10143 282 250
413441 AI929374 Hs 75367 Src-like-adapter 282 248
452651 AI218918 Hs 30209 KIAA0854 protein 282 1 13
422386 AF105374 Hs 115830 heparan sulfate (glucosamine) 3-O-sulfot 278 277
439778 AL109729 Hs 99364 putative transmembrane protein 2 77 1 92
434293 NM.004445 Hs 3796 EphB6 2 75 289
406642 AJ245210 gb Homo sapiens mRNA for immunoglobulin 270 203
406638 M13861 gb Human T-cell rxeptor xdve beta-cha 269 267
432331 W37862 Hs 274368 MSTP032 protein 268 308
408989 AW361666 Hs 49500 KIAA0746 protein 268 258
401731 NM.017990* Homo sapiens hypothedcal pro 268 253
401979 C17000767 gι|11990770|emb|CAC19651 1| (A 268 342
415539 AI733881 Hs 72472 BMP-R1B 268 251 425032 NM 001186 Hs 154276 BTB and CNC homology 1, basic leucine zi 267 2 13
406837 R70292 Hs 156110 immunoglobulin kappa constant 266 3 25
422550 BE297626 Hs 296049 microfibπllar-assxiated protein 4 266 274
425100 AF051850 Hs 154567 supervillin 265 280
452933 AW391423 Hs 288555 Homo sapiens cDNA FU22425 fis, ctone H 265 263
439706 AW872527 Hs 59761 ESTs, Weakly similar to DAP1.HUMAN DEATH 264 1 84
447232 AW499834 Hs 327 interieukin 10 rxeptor, alpha 263 263
425580 L11144 Hs 1907 galanm 262 200
450680 AF131784 Hs 25318 Homo sapiens clone 25194 mRNA sequence 261 1 80
412482 AI499930 Hs 334885 mitxhondnal GTP binding protein 261 1 82
433470 AW960564 transmembrane 4 superfamily member 1 260 244
419138 U48508 Hs 89631 rγanodme receptor 1 (skeletal) 260 247
401112 NM.024997* Homo sapiens hypothedcal pro 260 258
411802 AA733204 nuclear transcnpdon fador Y, gamma 259 232
407856 AA045281 Hs 266175 phosphoprotein assxiated with GEMs 259 1 88
425209 AL049761 Hs 155140 casein kinase 2, alpha 1 polypepdde 258 281
417165 R80137 Hs 302738 Homo sapiens cDNA FU21425 fis, clone C 256 210
442560 AA365042 Hs 325531 ESTs, Weakly similar to 2004399A chromos 2 55 397
408491 AI088063 Hs 7882 ESTs 254 274
420223 N27807 nbosomal protein L4 254 202
444467 AI150368 Hs 143844 ESTs 254 259
436729 BE621807 transmembrane 4 superfamily member 1 253 229
449217 AA278536 Hs 23262 nbonuclease, RNase A family, k6 253 1 80
453507 AF083217 Hs 33085 WD repeat domain 3 252 1 99
420315 NM 006299 Hs 96448 zinc finger protein 193 252 250
443060 D78874 HS 8944 procollagen C-endopepddase enhancer 2 2 50 235
453500 AI478427 Hs 43125 esophageal cancer related gene 4 protein 250 244
402692 Target Exon 250 1 73
427792 M63928 Hs 180841 tumor nxrosis fxtor rxeptor superfami 250 455
440065 W03476 Hs 266331 hypothedcal protein MGC4595 249 295
420568 F09247 Hs 247735 protxadheπn alpha 10 249 355
444115 AW954585 Hs 271920 ESTs, Weakly simila to Z195.HUMAN ZINC 249 252
404049 NM 018937* Homo sapiens protxadheπn be 248 267
417694 R09486 Hs 193118 ESTs 248 209
420600 BE011657 Hs 165695 ESTs, Weakly similar to unnamed protein 248 200
429922 Z97630 Hs 226117 H1 histone family, member 0 247 201
404752 NM.024778 Homo sapiens hypothedcal prot 247 307
421429 NM 014922 Hs 104305 death effector filament-forming Ced-4-lι 247 246
436378 AJ227874 Hs 99244 ESTs 246 1 88
429852 AB010445 Hs 225948 small inducible cytokine subfamily A (Cy 244 298
431190 AL134172 Hs 120852 ESTs 244 248
439979 AW600291 Hs 6823 hypothedcal protein FU10430 244 296
436608 AA628980 Hs 192371 down syndrome cπdcal region protein DS 244 316
445547 D86181 Hs 273 galxtosylceramidase (Krabbe disease) 243 333
443030 R68048 Hs 9238 hypothedcal protein FLJ23516 243 207
416908 AA333990 Hs 80424 coagulation fxtor XIII, A1 polypepdde 243 336
406782 AA430373 gb zw20f11 s1 Soares ovary tumor NbHOT H 240 338
407260 L09095 gb Homo sapiens mRNA fragment 238 378
419556 U29615 Hs 91093 chidnase 1 (chitotnosidase) 2 36 356
431365 AA504080 Hs 191958 immunoglobulin superfamily rxeptor tran 234 284
414555 N98569 Hs 76422 phospholipase A2, group IIA (platelets, 233 321
436485 X59135 Hs 156110 immunoglobulin kappa constant 2 31 294
403632 Target Exon 227 280
434232 AW297064 Hs 131862 ESTs 2 24 298
428114 AI821548 Hs 98363 ESTs, Weakly similar to I38022 hypothed 223 281
403294 Target Exon 2 19 281
429249 X81479 Hs 2375 egf-like module containing, muαn-like, 2 16 3 13
403295 Target Exon 215 295
427817 AA503373 Hs 186678 ESTs 2 13 280
425154 NM 001851 Hs 154850 collagen, type IX alpha 1 208 3 28
443176 AI696081 Hs 223770 ESTs 204 350
401770 C17001739" gι|2327052|gb|AAC48759 1| (U9 204 539
407124 R08160 gb yf 18a07 s 1 Soares fetal liver spleen 203 295
456060 C14904 Hs 45184 Homo sapiens cDNA FU12284 fis, clone MA 203 297
413053 AW963263 Hs 65377 ESTs, Moderately similar to KIAA1399 pro 201 342
426653 AA530892 Hs 171695 dual specificity phosphatase 1 201 305
410677 NM.003278 Hs 65424 tetranxdn (plasminogen-bindmg protein 201 358
401673 C16001416* gι|12743112|reflXP_010131 2| 1 99 499
420983 W95228 Hs 100764 cathepsin G 1 95 547
413624 BE177019 Hs 75445 SPARC-dke 1 (mastθ, hevin) 1 94 458
433554 AW957666 Hs 8108 disabled (Drosophila) homolog 1 1 93 282
405121 mitogen-xdvated protein kinase 8 inter 1 92 282
436456 AW292677 Hs 248122 G protein-coupled rxeptor 24 1 92 280
450852 AI983354 Hs 7740 oxysterol binding protein-like 1 1 91 508
432902 U75697 histone dexetylase 3 1 90 284
422100 AI096988 Hs 111554 ADP-πbosyladon fxtor-like 7 1 89 304
420162 BE378432 Hs 95577 cyclm-dependent kinase 4 1 87 285
424398 BE397787 Hs 146393 homxysteine-inducible, endoplasmic red 1 85 371
416714 AF283770 Hs 79630 CD79A antigen (immunoglobulin-assxiated 1 85 338
433465 AV657778 Hs 3314 selenoprotem P, plasma, 1 1 85 3 57
447990 BE048821 Hs 20144 small inducible cytokine subfamily A (Cy 1 82 6 17
421563 NM 006433 Hs 105806 granulysm 1 80 350
453804 AA300204 Hs 35276 KIAA0852 protein 1 78 287 429412 NM 006235 Hs 2407 POU domain class 2, assxiatmg fxtor 1 78 354
437866 AA156781 metallothionein 1E (funcdonal) 1 77 297
427751 AF000152 ∞nserved gene amplified in osteosarcoma 1 75 689
400442 DKFZP586G1722 protein 1 74 360
456898 NM 001928 Hs 155597 D component of complement (adipsiπ) 1 74 345
414477 U41635 Hs 76228 amplified in osteosarcoma 1 71 499
432870 AW974124 gb EST386227 MAGE resequences, MAGM Homo 1 68 286
456642 AW451623 Hs 109752 putadve c-Myc-responsive 1 68 309
456694 AW016382 Hs 105642 Homo sapiens cDNA FU23271 fis. clone H 1 66 283
430449 AA352723 Hs 241471 RNB6 1 65 284
401029 v-myc avian myelxytomatosis viral relat 1 65 288
402742 NM.002508 Homo sapiens nidogen (enxdn) 1 64 337
402559 Rho GTPase xtivadng protein 1 1 63 307
418271 NM 000919 Hs 83920 pepddylglycme alpha-amidating monooxyg 1 62 311
406851 AA609784 maior histocompadbil.ty ∞mplex, class 1 62 286
450912 AW939251 Hs 25647 v-fos FBJ muπne osteosarcoma viral onco 1 60 394
447029 AL137281 Hs 17110 Homo sapiens mRNA, cDNA DKFZp434C2016 (f 1 60 375
417739 Z43995 gb HSC1QB121 normalized infant bran cDN 1 59 296
452950 AA428123 Hs 302766 tyrosine 3-mon∞xygenase/tryptophan 5mo 1 58 295
427461 AA531527 Hs 332040 hypothetical protein MGC13010 1 58 4 11
444182 AW160432 Hs 296460 cramofxial development protein 1 1 57 298
407815 AW373860 Hs 183860 hypothedcal protein FU20277 1 57 388
452887 AI702223 Hs 107253 hypothedcal protein DKFZp761F241 1 56 288
416819 U77735 Hs 80205 pιm-2 oncogene 1 56 359
414583 AA362907 Hs 76494 proline arginine-nch end leucine-nch r 1 56 438
426104 AI204418 Hs 190080 ESTs 1 55 347
441591 AF055992 Hs 183 Duffy blood group 1 52 4 28
446406 AI553681 Arg/Ablπnterxdng protein ArgBP2 1 49 287
427343 AI880044 Hs 176977 protein kinase C binding protein 2 1 49 288
415550 L13720 Hs 78501 growth aπest-spxific 6 1 47 482
411961 AI478432 Hs 72956 hypermethylated in cancer 1 1 46 348
406213 ENSPOO0O02462O2* DJ63M22 (similar to AC 1 42 319
400847 NM.003105* Homo sapiens sortilin-related 1 41 297
404642 NM 021965* Homo sapiens phosphoglucomuta 1 40 302
452650 AW270150 Hs 254516 ESTs 1 40 286
432894 AW167668 Hs 279772 bran spxific protein 1 37 552
404030 NM.015669* Homo sapiens protxadhenn be 1 37 303
422033 AW245805 Hs 110903 claudin 5 (transmembrane protein deleted 1 35 315
413762 AW411479 Hs 848 FK505bιndιng protein 4 (59kD) 1 34 309
425367 BE271188 Hs 155975 protein tyrosine phosphatase, receptor t 1 32 3 29
415198 AW009480 Hs 943 natural killer cell transcnpt 4 1 32 289
406908 Z25437 gb H sapiens protem-tyrosine kinase gen 1 31 289
423959 AA333025 gb EST37122 Embryo, 8 week 1 Homo sapien 1 31 288
408135 AA317248 Hs 42957 methyltransferase-like 1 1 29 381
427523 BE242779 Hs 179526 upregulated by 1,25-dιhydroxyvιtamm D-3 1 29 325
415512 Y16270 Hs 78482 paralemmin 1 29 285
413531 AL036958 Hs 75416 DAZ assxiated protein 2 1 28 306
419608 AL037237 Hs 91586 transmembrane 9 superfamily member 1 1 27 280
424614 X54486 Hs 151242 senne (or cysteine) proteinase inhibito 1 26 290
422934 BE244189 Hs 122492 hypothedcal protein 1 25 341
450935 BE514743 tumor suppressor deleted in oral cancer- 1 25 363
416630 H69392 Hs 174051 small nuclear nbonucleoprotein 70kD pol 1 24 293
416950 AL049798 Hs 80552 dermatopondn 1 22 281
412558 AW962019 gb EST374092 MAGE resequences, MAGG Homo 1 21 302
419593 W73092 Hs 58282 ESTs 1 19 284
403470 Target Exon 1 14 282
402230 Fgenesh predicted CYTOCHROME P4504F5 ( 1 12 296
400559 Target Exon 1 00 290
412695 AW984439 gb PM3-HN0011-220300-002-C05 HN0011 Homo 1 00 284
427072 H38046 Hs 293981 ESTs 1 00 289
430439 AL133561 DKFZP434B061 protein 1 00 309
418183 NM 001772 Hs 83731 CD33 antigen (gp67) 1 00 293
TABLE 55B
Pkey Unic |ue Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank axession numbers
Pkey CAT Numbei Axession
406636 0 0 L12064 L12083 L12065 L12075 L12066 L12085 L12072 L12082 L120
430540 713 2 BC017171 BC012195 NM.007126 AF100752 AL137377 Z70768 BM4
BM045810 AU120387 BG770238 BG686740 BG913323 BI759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847 AI770171 BF196861 BE856897 AA463876 AI375927 AA648810 AA948193 AA490916 AI459893 AI458188 AI240408 AI191843 AI131029 AW768399 AI365196 AW337984 AW026150 BE466591 BE674599 AI818438 AA772197 AI651927 AW15114381198825 BG819083 BM458764 BE903567 BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542 AW246215 BE501897 BE903610 BE561530 BE5605378E903782 BE732947 BI227204 BG761305 BE262642 BE391848 BE382475 BG008258 BI547991 BI459099 BE391391 BE259420 BE298109 AW245422 AI423847 AI914618 H80534 BE301004 AL531791 AI435581 BF793112 AL577303 AA373265 BE746965 BF743630 BE879296 AI359493 BM018598AI689260 AW072450 F20201 AW151405 AW517572AA773468 BG259694 BE391163 BG621529 AI421728 BG767231 BM462953 BG340524 W52648 AA113434 BE785431 BI041981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 BI091658 N72512 W58732 W85690 BG958989 AI205206 H19721 W17051 W77958 BI262010 AA844319 W74143 W72214 N85194 BE734033 BG164099 AA931069 F13645 R41394 AK025758 BG180977 BE349455 AA812018 AA740241 AI027722 AI150356 AA886395 AW977627 BE220225 AA884082 AW518114 AI243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 AI251109 R07704 AA765606 AA724593 AI918399 AI537550 AA491103 AW008188 R07703 AA989120 AA746235 AW028983 AA789102 AU185751 AW971465 AA489681 AW971893 AW612086 BE077936 BI860809 BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591 430015 713.2 BC017171 BC012195 NM.007126 AF100752 AL137377 Z70768 BM474865 BG754806 AU124376 BG757203 BG764420 BG775028 BG824418
BM045810 AU120387 BG770238 BG686740 BG913323 BI759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847 AI770171 BF196861 BE856897 AA463876 AI375927 AA648810 AA948193 AA490916 AI459893 AI458188 AI240408 AI191843 AI131029 AW768399
AI365196 AW337984 AW026150 BE466591 BE674599 AI818438 AA772197 AI651927 AW151143 BI198825 BG819083 BM458764 BE903567 BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542 AW246215 BE501897 BE903610 BE561530 BE560537 BE903782 BE732947 BI227204 BG761305 BE262642 BE391848 BE382475 BG008258 BI547991 BI459099 BE391391 BE259420 BE298109 AW245422 AI423847 AI914618 H80534 BE3O1004 AL531791 AI435581 BF793112 AL577303 AA373265 BE746965 BF743630 BE879296 AI359493 BM018598 AI689260 AW072450 F20201 AW151405 AW517572 AA773468 BG259694 BE391163 BG621529 AI421728 BG767231 BM462953
BG340524 W52648 AA113434 BE785431 BI041981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 BI091658 N72512 W58732 W85690 BG958989 AI205206 H19721 W17051 W77958 BI262010 AA844319 W74143 W72214 N85194 BE734033 BG164099 AA931069 F13645 R41394 AK025758 BG180977 BE349455 AA812018 AA740241 AI027722 AI150356 AA886395 AW977627 BE220225 AA884082 AW518114 AI243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 AI251109 R07704 AA765606 AA724593 AI918399 AI537550 AA491103 AW008188 R07703 AA989120 AA746235 AW028983 AA789102 AU185751 AW971465 AA489681 AW971893 AW612086 BE077936 BI860809
BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591 455839 1518842.1 BE145823 BE145830 BE145884 BE145814 BE145905 BE145833 BE145834 BE145883 BE145889 406642 0.0 AJ245210 AJ245212 AJ245211 AJ245213
406638 0.0 M13861 433470 6624.1 X75684 AL573167 AI445461 A1453743 AI983655 AI564644 AA977180 AI694111 AI591358 AW071625 AI678712 AI720939 AI927769 BE439796
AI963432 AA292956 AW192593 AI865838 AI696905 AI424384 AI161312 AI911921 AI597801 BI494959 AI240988 AI492554 AW262737 BE044033 AW008570 AW629505 BI494958 AA088439 AA706057 BF222820 BF593608 BE501957 AA524526 BE044134 AW572531 AW015724 BE349186 AA043217 BE219784 AI799814 AA129575 AI671727 AI470033 BE646195 AW779725 AA903050 AA147228 AA404570 AI075878 W38161 AI972739 AW673152 AA72320O C06123 BF057147 AA627686 AA157944 AI990245 AA662517 T32487 AI800106 AI333170 AI859160 W45410 AI990827 AW275048 AA182640 AA478328 AI298935 AW085158 AW471421 AW103470 AW300456 AW191997 AI823466 AA962397 AA136658 AI251817
AW339104 AA724739 AA411100 AA191349 AA757735 AA037696 AI769516 AW772283 AA010631 AI692846 AI061065 H80983 R79933 AI950693 AI245632 AI349390 AA148284 AI798502 AA487893 AI621320 AW194272 C06365 AA953883 BE858936 AI918523 AI872628 AI927217 AI453453 AI189366 AW338678 AI261359 AI500576 BF477735 AI032569 AI972899 AI985583 Z28771 AI363829 AI693030 AA603586 BE773488 AW339301 BE773489 BE773462 BE773495 AI650338 BE773499 AI745717 BE811475 BE811470 BE811464 BE811418 BE811415 BE811400 BE811398 BE811388 BE811352 BE773501 BE773494 BE773486 BE773474 BE773473 BE773470 BE773461 BE811350 BE811337BF593847 BG055071
AW675302 BF003068 AA719173 BE811348 AI582462 AI686240 BE773500 AI244845 AI565439 AI918453 AI472527 AI446740 AA035576 AA191414 AW674145 C05782 AI589264 D57558 AI468237 AI432033 AA989662 R21752 BF002457 AA988297 AL574095 AL576200 AL571074 AL574525 AL578810 BG498381 AI928364 BE879732AA479834AA479712 C17732 BM091258 BF843901 AW820230 C17476 BE327120AA129574AA136645 BF843900 AW806193 AA502832 AA649494 AL568520 AL547960 BE706937 BE811360 BE773498 BE811401 BE773484 BE811437 BE811380 BE811399 BF997171 BF757734 BE926037 AI377596 C06111 AW088968 BE811404 BE811472 AI865912 AI925607 AI871950 AI093510 BE905927
BE811435 AA191387 AW772000 BE811453 BE614379 BF844522 BI044896 AI744233 AW984527 C17504 BF843883 AI248307 BE773483 AI567995 W60075 BF941183 AI738844 BE811 58 BE773481 AI262930 AA948565 BE706942 BE156360 T65026 AW242958 AW197954 BE905184 AA722206 AI344943 AI348877 AI334860 BE621857 BE156280 AA454099 AA037722 BF843897 AW806183 AA043216 BG482896 AA182734 AA877242 AW372926 H27252 R38114 BF851858 BE156214 AA190427 T91762 AA035067 AA837326 T10930 BF906587 BI755027 BG506731 BC008442 BC010166 AL550134 AL553096 AL548700 AL550751 AL547978 AL545286 AL540643 AU118627 AL601379 BI259821 BG741786 BI868522 AU135866
BI552770 BI259210 BI256520 BI255569 BG485098 BI258228 BG498501 BM044512 AU133984 AL556586 BE745111 BI222633 AU133917 BG288151 BI260715 BI550550 BG50O773 BI551761 BG707601 BI818593 BF691383 BG721129 BG541578 BE906666 BG751098 BI224135 BG400746 BG478065 BE790436 AW080238 AU137549 BG429896 BE392486 AW961686 BG721056 BE908365 BE546656 BG541235 AW583735 BG528290 BI260895 AW651691 BM048974 BM043805 BG142185 AA315188 AI446615 C06300 BG497644 AA088544 AI815987 BG528631 BE619182 AW239185 AW062910 AW062902 AA347236 F11933 AA4880O5 AA301631 AA376800 D56120 AA343532 AA308636 F00242 AA376086 AA316968 AA343799
BI870221 BE910282 BG538748 AW960564 AV732879 D16854 AA192519 BF922148 AA2160138G624091 BE544387 BG507008 AW176446 BF790033 BE088925 BE088854 AA921353 R21800 AA011222 T97525 411802 609.6 BF345917 AL549635 BI040919 AA733204 AA232382 T34425 T32000 BF906697 Z42382 BI544863 AL548378 AW816536 AW816719 BE152340
BF375392 AW816716 BE152336 BF375367 420223 191648.1 N27807 AA256634 BE276324
436729 6624.1 X75684 AL573167 AI445461 AI453743 AI983655 AI564644 AA977180 AI694111 AI591358 AW071625 AI678712 AI720939 AI927769 BE439796
AI963432 AA292956 AW192593 AI865838 AI696905 AI424384 AI161312 AI911921 AI597801 BI494959 AI240988 AI492554 AW262737 BE044033 AW008570 AW629505 BI494958 AA088439 AA706057 BF222820 BF593608 BE501957 AA524526 BE044134 AW572531 AW015724 BE349186 AA043217 BE219784 AI799814 AA129575 AI671727 AI470033 BE646195 AW779725 AA903050 AA147228 AA404570 AI075878 W38161 AI972739 AW673152 AA723200 C06123 BF057147 AA627686 AA157944 AI990245 AA662517 T32487 AI800106 AI333170 AI859160 W45410 AI990827
AW275048 AA182640 AA478328 AI298935 AW085158 AW471421 AW103470 AW300456 AW191997 AI823466 AA962397 AA136658 AI251817 AW339104 AA724739 AA411100 AA191349 AA757735 AA037696 AI769516 AW772283 AA010631 AI692846 AI061065 H80983 R79933 AI950693 AI245632 AI349390 AA148284 AI798502 AA487893 AI621320 AW194272 C06365 AA953883 BE858936 AI918523 AI872628 AI927217 AI453453 AI189366 AW338678 AI261359 AI500576 BF477735 AI032569 AI972899 AI985583 Z28771 AI363829 AI693030 AA603586 BE773488 AW339301 BE773489 BE773462 BE773495AI650338BE773499AI745717 BE811475 BE811470BE811464 BE811418 BE811415 BE811400 BE811398
BE811388 BE811352 BE773501 BE773494 BE773486 BE773474 BE773473 BE773470 BE773461 BE811350 BE811337 BF593847 BG055071 AW675302 BF003068 AA719173 BE811348 AI582462 AI686240 BE773500 AI244845 AI565439 AI918453 AI472527 AI446740 AA035576 AA191414 AW674145 C05782 AI589264 D57558 AI468237 AI432033 AA989662 R21752 BF002457 AA988297 AL574095 AL576200 AL571074 AL574525 AL578810 BG498381 AI928364 BE879732 AA479834 AA479712 C17732 BM091258 BF843901 AW820230 C17476 BE327120 AA129574 AA136645 BF843900 AW806193 AA502832 AA649494 AL568520 AL547960 BE706937 BE811360 BE773498 BE811401 BE773484 BE811437 BE811380
BE811399 BF997171 BF757734 BE926037 AI377596 C06111 AW088968 BE811404 BE811472AI865912 AI925607 AI871950 A1093510 BE905927 BE811435 AA191387 AW772000 BE811453 BE614379 BF844522 BI044896 AI744233 AW984527 C17504 BF843883 AI248307 BE773483 AI567995 W60O75 BF941183 AI738844 BE811458 BE773481 Al 262930 AA948565 BE706942 BE156360 T65026 AW242958 AW197954 BE905184 AA722206 AI344943 AI348877 AI334860 BE621857 BE156280 AA454099 AA037722 BF843897 AW806183 AA043216 BG482896 AA182734 AA877242 AW372926 H27252 R38114 BF851858 BE156214 AA190427 T91762 AA035067 AA837326 T10930 BF906587 BI755027 BG506731 BC008442
BC010166 AL550134 AL553096 AL548700 AL550751 AL547978 AL545286 AL540643 AU118627 AL601379 BI259821 BG741786 BI868522 AU135866 BI552770 BI25921081256520 BI255569 BG485098 BI258228 BG498501 BM044512 AU133984 AL556586 BE745111 BI222633 AU133917 BG288151 BI260715 BI550550 BG500773 BI551761 BG707601 BI818593 BF691383 BG721129 BG541578 BE906666 BG751098 BI224135 BG400746 BG478065 BE790436 AW080238 AU137549 BG429896 BE392486 AW961686 BG721056 BE908365 BE546656 BG541235 AW583735 BG528290 BI260895 AW651691 BM048974 BM043805 BG142185 AA315188 AI446615 C06300 BG497644 AA088544 AI815987 BG528631 BE619182 AW239185
AW062910 AW062902 AA347236 F11933 AA488005 AA301631 AA376800 D56120 AA343532 AA308636 F00242 AA376086 AA316968 AA343799 BI870221 BE910282 BG538748 AW960564 AV732879 D16854 AA192519 BF922148 AA216013 BG624091 BE5443878G507008 AW176446 BF790033 BE088925 BE088854 AA921353 R21800 AA011222 T97525 406782 0.0 AA430373AA968771 432902 35601.1 U75697 AI362269 AW575181 AL035820 AF039703 NM.003883 U66914 BE513355 BE302938 BE302936 BE303018 AA094475 F08725 R98879
R18769 BE019412 AA045846 AL120913 BE168807 BE168812 R21136 BE168915 H71247 N59055 AA533007 AW9387058E260952 BE313803 AA307436 AW951917 AW581926 AW277164 AI439049 AW581905 AI744899 AW804572 BE004443 AA335928 AA486355 AA115468 AA312123 R77086 AA595186 AW166991 AI952071 AW593311 AW571813 AI749734 AI674761 AI560970 AI480266 AA534470 AA737815 BE300597 AW022818 BE300599ΑA911621 AI074678 BE300694 AI187018 98969 AA456572 AI032111 AI830414 AA045874 AA932352 AI871262 T78896 AA714518
AW009272 T17250 R76914 AW317029 H71248 AA931900 AA282808 AI032140 AI208512 AI244759 AI420456 AI208085 AI283758 AI369297 R46731 H79779 AI349348 AW273644 AI559914 AI220114 AW615802 AA887531 AA810217 AA832227 AI567776 AI918324 AA862566 AA831038 AW246807 W78118 R43091 Z41762 AW135694 AW263376 AA115046 T34171 T34077 N53974 W79902 BE514017 BE513761 H79778 AW878598
437866 34267.1 U52054 AL581000 AA156850 AW293839 BI335865 AA024963 BF149420 BE073977 AW602574 BE164012 BE163992 BE163974 AW402161 BM194134 AW966609 W84374 BF916380 AA385173 W84366 AA383743 BF903598 AA043776 W84421 AA778446 AW444904 BF446960 AA837481 AV755539 AW468444 AW468002 AA811830 AA581806 AI866686 AI572124 AA687333020160 AA812489 AU 185248 AU 186004 AA156781 AI536733 BM144850 AI471883 AA040926 BF507639 AA043777 AW874142 BE832523 BE163972 BI022546 BI021204
427751 15028.1 BE875818 AW751975 W39241 BF808798 W22600 BF082190 AA031290 R42801 H98235 H17925 AI631236 AI933786 H42736 AF000152AU123911 AW410526 BM354207 BF800492 BM142340 BE019322 AL597008 AW327818 BI041915 AW504825 AW504941 BF987969 NM 005730 U81556 AI422831 AU154008 AA147822 AA873109 AI089244 AI360868 AW168024 AI819848 AA811327 AI355616 AA281629 AI880578 A1274316 AW014622 AI268660 AI270283 AA171981 AI349410 AA402469 AI421985 AI004864 AI423497 AI361503 AI363096 AW805345 AL539979 AA553967 AW502264 AI290698 N22420 AI281054 AI500699 AW342095 C75122 AW504577 AI130811 AI423567 R79086 AI860451 BE222885 AI697830 AI279575 BF438693 AW576277 BE218210 AI952376 AA506609 AI147566 AI391690 AA991622 AI696368 AI784664 AA741555 AI002681 AW474554 AW474508 D25623 AI493929 AA179800 W73566 AW411368 AA147971 AA088581 BF804510 AU145809 AU148108 AA223219 AU157840 AW169757 AI537862 N42341 AI128667 AW327853AA713915 W15255W56743 AA058322 H81878 AA723464 N27523 R37745 AA613566AL526353 AI905211 BF802713 N40338 AA249397 BF752939 BE250441 H64761 BF853011 H81877 H96088 AL576453 W73585 H39990 AW438965 BF899684 AI040299 AL561879 AA293821 H27760 BC018922 AL533396 BE513580 BF432649 AI884985 AA404264 AW024396 AW167863 AW027036 AI302177 AI660487 AW026086 BF432564 BF091011 AI193156 AA744623 AI859510 BI063081 BI061541 AA777036 BG058486 BI063555 AI349411 BF874521 AW139801 AI268585 AA401267 AI905209 R64276 N72043 AF022231 BI256540 AU134437 BG826972 BE298386 AW134499 AW206089 BF846730 AW500331 BF849336 BI041697 AI857745 AW192840 AW410527 AI697435 AW006631 AW504124 AL048926 AI085476 AW327855 AA459344 AW207516 AW204875 BM142514 BF436650 AA960980 AW242609 BI012363 AW837102 BE7031268E814612 BE837981 BE703141 BF343101 R47375 AA031413 N40264 BG027363 BF526360 BE391263 AA280192 BE294042 BE250630 AU147734 AU146610 AA196787 N59465 AW575791 H16738 H96089 H64762 AW0O6603 BE857292 AI719393 AU155418 BG770385 AA339673 BG337748 H42694 BE834346 AA090896 BE619985 BM006968 R46008 BF304621 AA172280 AW957721 BF304885 BF933455 BF809973 BG386280 AW079808 T51091 AL520569 BE694350 T06360 BF347780 BE560703 BE296629
432870 1238170.1 AW974124 AA572989 AA569080 406851 0.0 AA609784 R97304 417739 2145372 1 R12357 R34740 Z43995 446406 11004.1 BG105015 R45824 AI659533 AW022952 BM312713 C04108 AU159507 AW290967 AW235078 AW271693 AA999835 AL134290 AW235222 BM312405 AI480093 AI469044 AI308242 AI274858 AI824850 AI093881 BE857254 AW235980 AI985474 AI540755 W17232 056716 BE835412 AA091594 BE769194 BE769189 BE765413 BE766491 BF154895 BE765626 BF372247 BE769079 BE769122 BF154873 BF154880 Z26986 BE768478 BF372008 T34949 BE768476 BE768462 BF370113 BE835323 BE769217 BE769113 AA093838 BE769188 N88480 AA093969 AA092843
423959 887999.1 BE273069 AA333025 450935 4469 1 BE349913 BC002850 BC016704 NM 005851 AF089814 AK001498 AL537879 BG754157 AI129659 AI261895 BG397540 BF663515 AW517226 BG677982 AI435188 AI453123 Al 198380 AA524481 BG981512 AW269638 AI348113 AI095743 AA457108 AW044584 AU151602 AI744572 AI078741 AI879729 AI089613 AI568618 BF109806 AW440972 AA401965 AI027227 AI127506 AA434027 BF732901 AW264768 AA833667 AL038554 AI568161 AI350340 AA402084 BE677778 AA933621 BF663514 BG763563 AL574521 BG177226 BG759860 BE906329 AW161323 AI879350 BF946477 BF766208 AA633194 AL537880 AL038553 BG468205 BG761617 BI762655 BG436637 N49458 BI834722 BG397879 BI258799 AW004930 AA902847 AI832036 AW167549 AA743167 AA848017 AA365434 AI819503 AA767866 AI582000 N33615 AI950146 AA444029 AA227130 AA041525 AW339842 AA865972 AA8380O6 AW157822 AI890994 BI771150 BI821666 BE279491
412558 1227364.1 AW962019 BE389091 412695 1243394.1 AW984433 AW984393 AW984439 AW984451 AW984367 AW984371 AW984349 AW984356 AW984444 AW984443 AW984449 430439 6750.2 AL133561 AL117481 AL122069 AW439292 AI968826 AL041090
TABLE 55C
Pkey Unique number conesponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham, et al " refers to the publicadon endded "The ONA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposidon Indicates nudeodde positions of predicted exons
Pkey Ref Strand Nt position
404854 7143420 Plus 1426514537
402294 2282012 Minus 25753000
402737 9212184 Minus 1335513552
404995 6006247 Minus 154015154123
401284 9800819 Minus 101307-101421
405757 3334694 Minus 6682570466
401731 9690317 Plus 4383543963,44787-44935,4569845810,4741
401979 2828778 Minus 75693-75851,76977-77112
401112 9966198 Minus 6062561041
402692 8468956 Plus 124605125387
404049 3688074 Minus 7576578155
404752 7109522 Minus 120165120326
403632 8572864 Minus 35197-35358
403294 8096496 Plus 4156541881
403295 8096528 Plus 2238522708
401770 9958312 Plus 183424-183576
401673 7689903 Minus 122587-122705, 122765123047
405121 8102330 Minus 3581536004,36587-36684
400442 9887672 Plus 59362-59574
401029 8117523 Plus 41999-42172
402742 9212200 Minus 23487-23613
402559 9864273 Plus 33539-33715
406213 7342019 Plus 25921-26612,34539-35161
400847 9188605 Plus 4464544835
404642 9796810 Plus 102999-103145
404030 7671252 Plus 149362-151749
403470 9929739 Minus 83758552
402230 9966312 Minus 29782-29932
400559 9843598 Plus 75483-75584 TABLE 56A ABOUT 277 GENES UPREGULATED IN MELANOMA METASTASES RELATIVE TO BENIGN NEVI
Table 56A lists about 277 genes upregulated in melanoma metastases reladve to benign nevi Genes were selxted from 59680 probesets on the Eos/Affymetnx Hu03 Genxhip array Gene expression data for exh probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflxdng the reladve level of mRNA expression Pkey Unique Eos probeset identifier number
ExAxn Exemplar Axession number, Genbank accession number
UnigenelD Unigene number
Unigene Tide Unigene gene dtle
R1 70th percendle of melanoma metastasis Als divided by the maximum of benign nevi Als R2 70th percentile of melanoma metastasis Als divided by the maximum of benign nevi Als, where the 1 Sth percendle of normal dssue Als was subtrxted from both the numerator and denominator
Pkey ExAxn UnigenelD Unigene Tide R1 R2
422424 AI186431 Hs 296638 prostate differenbadon fxtor 1373 17 18
446619 AU076643 Hs 313 sxreted phosphoprotein 1 (osteopontin, 11 67 13 25
407846 AA426202 Hs 40403 Cbp/p300-ιnterxdng transxdvator, wit 935 875
444381 BE387335 Hs 283713 ESTs, Weakly simila to S64054 hypothed 863 622
417880 BE241595 Hs 82848 selxdn L (lymphxyte adhesion molxule 8 21 865
424321 W74048 Hs 1765 lymphxyte-specific protein tyrosine kin 7 13 504
447210 AF035269 Hs 17752 phosphaddylseπne-spxific phospholipas 679 7 12
417693 AW959741 Hs 40368 adaptor-related protein complex 1, sigma 655 594
429500 X78565 Hs 289114 hexabrxhioπ (tenaxin C, cytotxdn) 643 346
414812 X72755 Hs 77367 monokine induced by gamma interferon 643 544
451736 AW080356 Hs 23889 ESTs, Weakly simila to ALU7.HUMAN ALU S 631 608
418870 AF147204 Hs 89414 chemokine (C-X-C modf), rxeptor 4 (fus 620 604
428291 AA534009 Hs 183487 interferon sdmulated gene (20kD) 603 472
417308 H60720 Hs 81892 KIAA0101 gene product 601 707
448569 BE382657 Hs 21486 signal transducer and xdvator of trans 599 8 88
439310 AF086120 Hs 102793 ESTs 595 663
452838 U65011 Hs 30743 preferentially expressed andgen in mela 595 377
422241 Y00062 Hs 170121 protein tyrosine phosphatase, receptor t 576 637
442379 NM.004613 Hs 8265 transglutaminase 2 (C polypepdde, prote 576 3 14
409274 NM.003930 Hs 52644 SKAP55 homologue 565 501
442739 NM.007274 Hs 8679 cytosolic xyl coenzyme A thioester hydr 558 350
442711 AF151073 Hs 8645 hypothetical protein 545 584
425118 AU076611 Hs 154672 methylene tetrahydrofolate dehydrogenase 542 575
412918 BE563957 x vated RNA polymerase II transcnptio 535 494
428125 AA393071 Hs 182579 leucine ammopepddase 533 5 34
446921 AB012113 Hs 16530 small inducible cytokine subfamily A (Cy 533 498
431183 NM.006855 Hs 250696 KDEL (Lys-Asp-Glu-Leu) endoplasmic rede 530 625
414219 W20010 Hs 75823 ALL1-fused gene from chromosome 1q 5 16 5 33
426600 NM.003378 Hs 171014 VGF nerve growth fxtor inducible 505 877
415444 BE247295 Hs 78452 solute earner family 20 (phosphate tran 503 5 17
436701 AW959032 ESTs, Moderately similar to I78885 seπn 503 4 17
406648 AA563730 Hs 277477 major histocompadbility complex class 499 508
410850 AW362867 Hs 302738 Homo sapiens cDNA FLJ21425 fis, clone C 498 471
418299 AA279530 Hs 83968 integnn, beta 2 (andgen CD18 (p95), ly 498 4 08
432469 AL080084 CG1 100 protein 497 470
404854 Target Exon 485 407
415701 NM.003878 Hs 78619 gamma-glutamyl hydrolase (conjugase, fol 4 82 490
425397 J04088 Hs 156346 topoisomerase (DNA) II alpha (170kD) 481 345
408958 T99607 Hs 9346 signal rxognidon particle 54kD 478 234
453949 AU077146 Hs 36927 heat shxk 105kD 478 632
458079 AI796870 Hs 54277 DNA segment on chromosome X (unique) 992 477 657
440245 AK001913 Hs 7100 hypothedcal protein 74 383
412228 AW503785 Hs 73792 ∞mplement component (3d/Epsteιn Barr vi 474 553
417834 BE172058 Hs 82689 tumor rejxdon andgen (gp96) 1 473 435
451003 AF058696 Hs 25812 Ni|megen breakage syndrome 1 (nibnn) 467 460
424571 BE379766 pdymerase (RNA) II (DNA directed) polyp 462 350
434203 BE262677 Hs 283558 hypothedcal protein PR01855 461 567
452268 NM.003512 Hs 28777 H2A histone family, member L 460 379
421311 N71848 Hs 283609 hypothetical protein PRO2032 460 3 58
410491 AA465131 Hs 64001 Homo sapiens clone 25218 mRNA sequence 460 468
425706 AW406678 Hs 122559 hypothetical protein FU22570 459 383
450293 N36754 Hs 171118 hypothedcal protein FLJ00026 457 540
406836 AW514501 Hs 156110 immunoglobulin kappa constant 457 633
413441 AI929374 Hs 75367 Src-like-adapter 453 4 77
431129 AL137751 Hs 263671 Homo sapiens mRNA, cDNA DKFZp434l0812 (f 448 4 89
418506 AA084248 Hs 85339 G protein-coupled rxeptor 39 447 4 17
411060 NM.006074 Hs 318501 Homo sapiens mRNA full length insert cDN 447 4 33
417501 AL041219 Hs 82222 sema domain, immunoglobulin doman (Ig), 445 3 32
437763 AA469369 Hs 5831 dssue inhibitor of metalloproteinase 1 443 4 43
448883 BE614989 Hs 7503 hypothedcal protein FLJ14153 442 391
417274 N92036 Hs 81848 RAD21 (S pombe) homdog 441 409
419285 D31887 Hs 89868 KIAA0062 protein 440 356
418321 063477 Hs 84087 KIAA0143 protein 4 38 300
430154 AW583058 Hs 234726 senne (or cysteine) proteinase inhibito 437 4 26
428450 NM.014791 Hs 184339 KIAA0175 gene product 436 490
428297 AA236291 Hs 183583 senne (or cysteine) proteinase inhibito 4 36 3 57
447232 AW499834 Hs 327 interieukin 10 receptor, alpha 436 407
409598 NM 014018 Hs 55097 mitxhondπal nbosomal protein S28 4 35 3 29
442432 BE093589 Hs 38178 hypothetical protein FU23468 434 580
407047 X65965 gb H sapiens SOD-2 gene for manganese su 433 3 51 443991 NM 002250 Hs 10082 potassium intermediate/small conductance 4 33 423
452322 BE566343 Hs 28988 glutaredoxin (thioltransferase) 4 32 268
420991 AW504814 Hs 287379 Homo sapiens mRNA for FU00111 protein, 4 32 454
449722 BE280074 Hs 23960 cyclm B1 431 373
408380 AF123050 Hs 44532 diubiquidn 430 5 74
427127 AW802282 Hs 22265 pyruvate dehydrogenase phosphatase 4 28 480
417933 X02308 Hs 82962 thymidylate synthetase 428 359
432828 AB042326 Hs 287402 chondroidn 4-sulfotransferase 4 25 4 15
450306 AL080080 Hs 24766 thioredoxin domain-containing 424 315
440266 AA088809 Hs 19525 hypothedcal protein FU22794 4 23 412
407951 W77762 Hs 79015 andgen identified by monoclonal antibod 4 22 464
427337 Z46223 Hs 176663 Fc fragment of IgG, tow affinity lllb, r 420 462
408989 AW361666 Hs 49500 KIAA0746 protein 420 492
449626 AA774247 Hs 301637 zix finger protein 258 4 19 317
422846 BE513934 HS 1583 neutrophil cytosolic factor 1 (47kD, chr 418 891
415726 T89844 Hs 8712 ammolevulinate, delta-, synthase 1 4 16 421
444207 AI565004 cathepsin D (lysosomal aspartyl protease 4 16 1 89
416980 AA381133 Hs 80684 high-mobility group (nonhistone chromoso 414 330
438718 AL040058 Hs 6375 uncharxteπzed hypothalamus protein HT0 4 14 304
437802 AI475995 Hs 122910 ESTs 4 12 5 13
446392 AF142419 Hs 15020 homolog of mouse quaking OKI (KH domain 412 387
409461 AA382169 Hs 54483 N-myc (and STAT) interxtor 4 11 496
427247 AW504221 Hs 174103 integnn, alpha L (andgen CD11 A (p180), 411 637
414359 M62194 Hs 75929 cadhenn 11, type 2, OB-cadhenn (osteob 410 416
450071 AA018283 Hs 24359 Homo sapiens cDNA FU11174 fis, clone PL 4 10 235
452882 AW972990 Hs 196270 folate transporter/earner 410 450
414522 AW518944 Hs 76325 Immunoglobulin J chain 409 607
407756 AA116021 Hs 38260 ubiquitin spxific protease 18 409 503
405506 Taget Exon 408 371
417497 AW402482 Hs 82212 CD53 andgen 407 861
413715 AW851121 Hs 75497 Homo sapiens cDNA FU22139 fis, Clone H 406 405
421508 NM 004833 Hs 105115 absent in melanoma 2 405 461
445701 AF055581 Hs 13131 lymphxyte adaptor protein 402 456
443071 AL080021 Hs 8986 ∞mplement component 1, q subcomponent 400 891
417615 BE548641 Hs 82314 hypoxanthine phosphoπbosyltransferase 1 399 4 15
444371 BE540274 Hs 239 forkhead box M1 386 458
450515 AW304226 biphenyl hydrolase-like (senne hydrolas 385 426
446506 AI123118 Hs 15159 chemokine-like fxtor, altemadvely spl 381 406
410668 BE379794 Hs 159651 hypothetical protein 380 684
443710 AI928136 Hs 9691 Homo sapiens cDNA FU23249 fis, clone C 377 446
406837 R70292 Hs 156110 immunoglobulin kappa constant 377 644
419381 AB023420 Hs 90093 heat shxk 70kD protein 4 376 400
402474 NM.004079 Homo sapiens cathepsin S (CTSS 376 467
454080 AI199711 Hs 576 fucosidase alpha-L- 1 , dssue 374 622
409264 NM 014937 Hs 52463 KIAA0966 protein 369 436
428398 AI249368 Hs 98558 ESTs 368 518
423494 AW504365 Hs 24143 Wiskott-Aldπch syndrome protein interx 367 412
414829 AA321568 Hs 77436 plxkstnn 365 445
437239 AW503395 Hs 5541 ATPase, Ca transporting, ubiquitous 363 484
433867 AK000596 Hs 3618 hippxalcm-like 1 3 59 449
432485 N90866 Hs 276770 CDW52 andgen (CAMPATH-1 andgen) 354 531
418310 AA814100 Hs 86693 ESTs 349 4 57
406868 AA505445 Hs 300697 immunoglobulin heavy constant gamma 3 (G 348 433
438746 AI885815 Hs 184727 Human melanoma-assxiated andgen p97 (m 347 687
427527 AI809057 Hs 153261 immunoglobulin heavy constant mu 344 1042
442485 BE092285 Hs 29724 hypothetical protein FU13187 341 460
432606 NM.002104 Hs 3066 granzyme K (senne protease, granzyme 3, 340 450
435080 AI831760 Hs 155111 hypothedcal protein FU 14428 340 422
436810 AA353044 Hs 5321 ARP3 (xdn-related protein 3, yeast) ho 340 503
422545 X02761 Hs 287820 fibronxtin 1 339 7 32
409142 AL136877 Hs 50758 SMC4 (structural maintenance of chromoso 336 447
434826 AF155661 Hs 22265 pyruvate dehydrogenase phosphatase 334 502
416975 NM 004131 Hs 1051 granzyme B (granzyme 2 cytotoxic T-lymp 334 424
448410 AK000227 Hs 21126 hypothetical protein FLJ 20220 333 4 29
432642 BE297635 Hs 3069 heat shxk 70kD protein 9B (mortalιn-2) 3 32 448
425234 AW152225 Hs 165909 ESTs, Weakly similar to I38022 hypotheti 324 464
443623 AA345519 Hs 9641 complement component 1, q subcomponent. 3 23 1358
426490 NM 001621 Hs 170087 aryl hydrocarbon rxeptor 323 4 20
443958 BE241880 Hs 10029 cathepsin C 3 16 505
407862 BE548267 Hs 337986 Homo sapiens cDNA FU10934 fis, clone OV 315 404
412577 Z22968 Hs 74076 CD163 andgen 3 14 532
414050 NM 004766 Hs 75724 ∞atomer protein complex, subunit beta 2 313 465
442904 AW575008 Hs 11355 thymopoietin 3 13 434
421633 AF121860 Hs 106260 sorting nexm 10 3 12 499
413936 AF113676 Hs 297681 serine (or cysteine) proteinase inhibito 311 547
428797 AA496205 Hs 193700 Homo sapiens mRNA, cDNA DKFZp586l0324 (f 3 10 430
408515 AI289507 Hs 299883 hypothetical protein FU23399 310 403
409442 AA310162 Hs 169248 cytxhrome c 307 400
456373 BE247706 Hs 89751 membrane-spanning 4-domans, subfamily A 304 438
430413 AW842182 Hs 241392 small inducible cytokine A5 (RANTES) 304 5 53
418526 BE019020 Hs 85838 solute earner family 16 (monxarboxylic 303 4 97
452139 AA099969 Hs 16331 Homo sapiens cDNA FLJ21482 fis, clone C 301 487
430478 NM 014349 Hs 241535 apolipoprotein L, 3 298 444 439237 AW408158 Hs 318893 ESTs, Weakly similar to A47582 B-cell gr 295 745
406782 AA430373 gb zw20f11 s1 Soares ovary tumor NbHOT H 293 849
450455 AL117424 Hs 25035 chlonde intracellular channel 4 290 508
422530 AW972300 Hs 118110 bone marow stromal cell antigen 2 287 707
429490 AI971131 Hs 23889 ESTs, Weakly similar to ALU7.HUMAN ALU S 287 4 29
410231 AA314163 Hs 61153 proteasome (prosome, mxropan) 26S subu 282 5 53
419956 AL137939 Hs 40096 cadheπn 19, type 2 280 4 26
416511 NM 006762 Hs 79356 Lysosomal-assxiated muldspanning membr 279 555
421712 AK000140 Hs 107139 hypothedcal protein 279 6 29
429732 U20158 Hs 2488 lymphxyte cytosolic protein 2 (SH2 doma 278 474
448517 AA082750 Hs 42194 hypothedcal protein FU22649 similar to 278 4 69
427792 M63928 Hs 180841 tumor nxrosis fxtor rxeptor superfami 277 5 18
446272 BE268912 Hs 14601 hematopoiedc cell-sp ific Lyn substrat 275 490
422173 BE385828 Hs 250619 phorbolm-like protein MDS019 (CEM15) 275 4 33
446566 H95741 Hs 17914 membrane-spanning 4-domans, subfamily A 272 4 19
429402 AF116571 Hs 201671 SRY (sex deteimming region Y)-box 13 272 5 15
421360 AA297012 Hs 103839 erythrocyte membrane protein band 4 1-lι 271 482
425762 BE244076 Hs 159578 AT-hook transcnpdon fxtor AKNA 271 461
429412 NM 006235 Hs 2407 POU domain, dass 2, assxiadng fxtor 269 445
409202 AA236881 Hs 51043 hexosamimdase B (beta polypepdde) 268 489
426124 AI268389 Hs 250697 phosphatidylmositol glycan, class F 268 4 25
422672 X12784 Hs 119129 collagen, type IV, alpha 1 267 500
417389 BE260964 Hs 82045 midkine (neuπte growth-promodng fxtor 265 954
445784 AI253155 Hs 146065 ESTs 265 4 11
410341 AW499985 Hs 42915 ARP2 (xdn-related protein 2, yeast) ho 264 450
422603 BE242587 Hs 118651 hematopoiedcally expressed homeobox 263 4 17
424687 J05070 Hs 151738 matnx metalloproteinase 9 (geladnase B 262 580
410016 AA297977 Hs 57907 small inducible cytokine subfamily A (Cy 261 5 57
424779 AL046851 Hs 153053 CD37 andgen 260 572
420224 M84371 Hs 96023 CD19 andgen 260 402
421924 BE514514 Hs 109606 coronin xdn binding protein, 1A 257 483
426143 BE379836 proteasome (prosome, mxropan) subunit, 256 450
421563 NM 006433 Hs 105806 granulysin 256 535
425593 AA278921 Hs 1908 proteoglycan 1, sxretory granule 255 432
428169 AI928984 Hs 182793 golgi phosphoprotein 2 254 578
417022 NM 014737 Hs 80905 Ras assxiadon (RalGDS/AF-6) domain fam 254 409
414646 AA353776 Hs 901 CD48 antigen (B-cell membrane protein) 253 441
429800 AA333375 Hs 223014 andzyme inhibitor 250 568
407241 M34516 gb Human omega light chain protein 14 1 250 469
421739 AB004550 Hs 107526 UDP-Gal betaQcNAc beta 1,4- galxtosylt 245 435
412819 T25829 Hs 24048 FK506 binding protein precursor 245 466
435523 T62849 Hs 11090 membrane-spanning 4-domaιns, subfamily A 244 491
434883 AW381538 Hs 19807 hypothedcal protein MGC12959 241 480
420340 NM 000734 Hs 97087 CD3Z antigen, zeta polypepdde (TιT3 com 241 400
449296 AL137257 Hs 23458 Homo sapiens cDNA FLJ23015 fis, clone L 241 4 77
417370 T28651 Hs 82030 trγptophanyl-tRNA synthetase 241 404
400223 Eos Control 239 547
431629 AU077025 Hs 265827 interferon, alpha-inducible protein (do 238 767
414622 AI752666 Hs 76669 nicodnamide N-methyltraπsferase 2 38 532
415149 X12451 Hs 78056 cathepsin L 237 807
435099 AC004770 Hs 4756 flap structure-spxific endonuclease 1 2 37 523
454390 AB020713 Hs 56966 KIAA0906 protem 2 35 457
427407 BE268649 Hs 177766 ADP-nbosyltransferase (NAD, poly (ADP-r 231 548
449029 N28989 Hs 22891 solute earner family 7 (cadonic am o 2 24 408
438956 W00847 Hs 135056 Human DNA sequence from ctone RP5850E9 223 402
423397 NM 001838 Hs 1652 chemokine (C-C modf) rxeptor 7 2 23 490
416232 AW502678 Hs 79090 exportm 1 (CRM1 yeast, homolog) 2 18 497
436692 AW243158 Hs 5297 DKFZP564A2416 protein 2 17 4 13
420842 AI083668 Hs 50601 hypothedcal protein MGC10986 2 14 5 14
428227 AA321649 Hs 2248 small inducible cytokine subfamily 8 (Cy 2 13 443
429642 X68264 Hs 211579 melanoma cell adhesion molxule (MCAM) ( 2 11 542
416448 L13210 Hs 79339 Ixdn, galxtoside-bindiπg, soluble, 3 2 10 636
416714 AF283770 Hs 79630 CD79A antigen (immunoglobulm-assxiated 2 10 406
409220 BE243323 Hs 51233 tumor nxrosis fxtor rxeptor superfami 209 467
414045 NM 002951 Hs 75722 πbophoπn II 207 432
422451 AA310753 Hs 42491 ESTs, Weakly similar to S65657 alpha-1 C- 207 4 24
441211 AW946155 Hs 7750 hypothedcal protein AL133206 206 464
434692 H06586 Hs 94 DnaJ (Hsp40) homdog, subfamily A, membe 205 4 33
452363 AI582743 Hs 94953 Homo sapiens, Simila to complement comp 204 1336
438393 AA351815 Hs 50740 Homo sapiens cDNA FU22272 (is, clone H 203 4 52
413313 NM 002047 Hs 283108 glycyl-tRNA synthetase 202 4 11
452700 AI859390 Hs 288940 five-span transmembrane protein M83 200 404
406621 X57809 Hs 8997 immunoglobulin lambda Ixus 1 99 4 35
424415 NM 001975 Hs 1 6580 enolase 2, (gamma, neuronal) 1 98 452
429451 BE409861 Hs 202833 heme oxygenase (dxyclmg) 1 1 95 560
416967 BE616731 Hs 80645 interferon regulatoiγ fxtor 1 1 95 538
414945 BE076358 Hs 77667 lymphxyte andgen 6 complex, Ixus E 1 93 469
418917 X02994 Hs 1217 adenosine deaminase 1 91 432
445411 AL137255 Hs 12646 hypothedcal protein FLJ22693 1 91 448
413945 NM 000591 Hs 75627 CD14 andgen 1 90 603
429119 AV660012 Hs 196437 hypothetical protein FU 10788 1 90 408
413317 U53225 Hs 75283 sorting nexin 1 1 89 406
427239 BE270447 ubiquitin earner protein 1 87 598 450440 AB024334 Hs 25001 tyrosine 5monooxygenase/tryptophan 5mo 1 87 6 33
413142 M81740 Hs 75212 omithine dxart-oxylase 1 1 85 4 21
447131 NM 004585 Hs 17466 retinoic xid rxeptor responder (tazao 1 84 507
430040 AW503115 Hs 227823 pM5 protein 1 83 557
416819 U77735 Hs 80205 pιm-2 oncogene 1 83 412
425356 BE244879 Hs 155939 inositol polyphosphate-5phosphatase. 14 1 82 571
414570 Y00285 Hs 76473 insulin like growth fxtor 2 receptor 1 81 473
443639 BE269042 Hs 9661 proteasome (prosome, mxropan) subunit 1 80 471
418707 U97502 Hs 87497 butyrophil , subfamily 3, member A2 1 78 5 16
425367 BE271188 Hs 155975 protein tyrosine phosphatase, receptor t 1 78 700
409154 U72882 Hs 50842 interferon-induced protein 35 1 74 5 10
444954 AW247076 Hs 12163 eukaryodc fransladon initiation fxtor 1 71 5 15
424825 AF207069 Hs 153357 prxollagen-lysine, 2-oxoglutarate 5dιo 1 70 443
428385 AF112213 Hs 184062 putadve Rab5ιnterxdng protein 1 69 406
427378 BE515037 Hs 177556 melanoma andgen, family D, 1 1 67 568
413322 AA380158 Hs 75290 ADP-πbosyladon fxtor 4 1 67 456
442414 BE408758 Hs 8297 πbonuclease 6 precursor 1 65 440
410129 BE244074 Hs 58831 regulator of Fas-induced apoptosis 1 64 402
452472 AW957300 Hs 294142 ESTs, Weakly similar to C55663 oligodend 1 63 449
446143 BE245342 Hs 306079 sec61 homolog 1 62 473
413511 AI627178 Hs 75412 arginine-nch, mutated in early stage tu 1 60 4 19
415017 F06434 Hs 77805 ATPase, H transporting, lysosomal (vxuo 1 60 461
410361 BE391804 Hs 62661 guanylate binding protein 1, interferon- 1 59 426
410068 AI633888 Hs 58435 FYN-bmding protein (FYB-120/130) 1 56 4 10
419489 AW411280 Hs 90693 replicadon initiation region protein (6 1 55 430
439627 8E621702 Hs 29076 hypothetical protein FU21841 1 55 654
414427 L19711 Hs 76111 dystroglycan 1 (dystroph -assxiated gl 1 53 400
416971 R34657 Hs 80658 uncoupling protein 2 (mitxhondπal, pro 1 53 479
426059 BE292842 Hs 166120 interferon regulatory fxtor 7 1 51 4 12
418879 AW162087 Hs 5437 Taxi (human T-cell leukemia virus type I 1 50 493
433271 BE621697 Hs 14317 nucleolar protein family A, member 3 (H/ 1 45 4 15
422481 AL050163 Hs 117339 DNAX-xdvatioπ protein 10 1 45 403
432805 X94630 Hs 3107 CD97 antigen 1 43 4 11
447150 AI439011 Hs 86386 myeloid cell leukemia sequence 1 (BCL2-r 1 43 408
421975 AW961017 Hs 6459 hypothedcal protein FU11856 1 41 436
427458 BE208364 Hs 29283 ESTs, Weakly simila to LKHU proteoglyca 1 41 4 10
412968 AW500508 Hs 75102 alanyl-tRNA synthetase 1 40 4 25
428511 AA019912 Hs 184693 transcπption elongadon fxtor B (Sill) 1 38 491
413825 BE299181 Hs 75564 CD151 andgen 1 37 446
427496 D21260 Hs 178710 clathnn, heavy polypepdde (He) 1 30 404
407143 C14076 Hs 332329 EST 1 29 437
TABLE 56B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accessior i Genbank xcession numbers
Pkey CAT Number Axession
412918 2764.3 BE784583 AL519009 AV755430 AV756363 AV711927 BI523434 AI521453 AA846815 AW024829 AW9
AA946555 AA723580AA612925 BG105326 BG532618 AW513994 AW602165AI373448 AA907901 AW135104 BG186662 W69205 BG219754 BE774875 BG190378 AA483698 BE0660668E066067 BE066062 AW304207 BE939361 AW795569 BG210592 AW795644 BE939358 AW102886 BE065977 BG182971 H97042 D58090 BI046351 H81248 AI750112 AW372079 C05492 D58287 D57835 AA935095 BF700910 BG215802 BG195459 AW368467 BG495535 BG533177 BI087962 BE541579 BF130753
436701 28142.1 Z69892 AA210833 BM353155 AI473754 AI147901 AI803109 AA843296 AA418925 AI478552 AI400067 AI360304 AA418828 AW301673 BE218952
AI632804 BF433234 AA394157 BF378047 BE467036 AA319724 AW290940 AI222671 AI347724 AW001711 AI028652 AA398130 AI470582 AI915936 AA908929 C75102 N36920 H50440 AI919034 AI004399 AI383862 AI123606 AA648518 AA516258 AI865321 N22865 AA848101 AI589792 AA758196 AA214630 AI373911 AW194733 AA213447 AI290291 BF437165 AA757592 BFO86904 AW959032 AW992466 BF446888 AI936337 BE938849 AW149064 AI701629 N90021
432469 58644 1 BC016556 BC016365 NM.016040 AF151858 BI561037 AW966873 AW967497 BE219482 BE018650AW770511 AW469095AW470133 BM150181
BM193977 AI824135 AI632346 AI129838 BM147664 AI292112 BE244667 AA251084 AW503659 BM193866 BM194481 BF446862 AL597435 BF000262 AI824386 AI990100 AW087624 AA668793 AL080084 BI335866 BI820940 BG779242 BM069854 AA282620 AA256771 AW964511 AA451623 H00335 AW370399 AW954201 BM145846 BG111760 AI750065 BG655794 AA564086 BG494071 BM069606 AI675331 BE302224 AI476466 AI625980 BM144854 AI184602 AI343932 AW136586 AW029464 AI708651 AA824243 BM145917 AA662210 AA825708 AI335858 AI273704 AA662171 N48971 AA976614 AI344537 AA609603 AI873901 AI859995 AA833589 AA765811 AI150322 AI926816 BM148634 N98862AA019347 AA897062AA831100 N69889 BE243185 AA282179 AA831098 AA112676 AI702407 BG621752 BE006492 AA353202 BG674256 N46921 BI048774 AW300233 BF739890 AW966879 AA393405 BF115146 AA910851 AA013099 N28878 AA287713 BE348728 BG616446 AL599953 AL599952 BF381073 AW505056 AA094735 H03613 AA287714 H27168 R54718 BF792697 AV693603 AV685883 BG619956 BF541504 BF216789 AA319751 BM452652 BF335838 AA280397 BG171509 BF571997 AA490239 AW388161 BE842126 BG165309 N71903 AI955397 AI536898 BE242040 F09718 AA772421 AA450218 M78543 BE241414 AA013098 H00297 AW576477 AW150918 AW591371 AI382711 N71926 H72497 AI285602 AA745055 AI281647 BF377670 T65207 BG532880 BG721680 AA285143 H27167 AW500235 BG494497 BF668899
424571 9758.1 BE379766 AW152643 AI803450 AI564343 AI092711 AI140525 AW152156 AI620740 AI554689 AI161209 AI290242 AI339745 AI374611 AI347388
AI858296 Al 140529 Al 366124 AA493912 AA406235 AA493889 AI057160 AW022264 AI097277 AI144126 AI080051 AA983529 AA860507 N53469 AA843767 N81163 N70628 AA424577 AA983537 BF003004 AA626688 AA235977 AI057152 AI095366 AI095356 AA458646 AW194479 AA150439 AI375272 AW571777 AI359198 AA993793 BE6143948E738239 AA127883 AI034344 T59504 D81608 AA908704 AW051665 AA382785 AA307208 N24639 AI370715 BE244980 AA548596 AW449675 AI191008 BF223749 N70752 N22266 AI191012 AA028001 AI419106 BF215661 BF591548 BG942356 AI474968 BE858217 BF793358 AV756758 BG483603 AI093724 BF693395 BG545345 AI744294 T59549 AA811773 BG499757
444207 9172.3 BE739425 AA514221 AA865491 AI828293 AA470456 AI276739 AA169357 BE932464 AA514889 AW819039 AW819083 BE843048 AI432496 AI470335
AI247243 BG533994 AA513783 AI887309 AA528036 AW972006 AW873028 AI924914 AI818810 AW152378 AW084946 AI521413 AI669583 BE932521 AI581370 BE180238 AW089750 AW771461 AW089714 Al 590949 AI819148 AA731056 BF815234 BF911506 AA235803 AA485373 AI735658 AW393133 AW073080 AI707637 BF353320 BE843111 AW819036 AW393135 BG697291 AV648670 AV654332 AV687530 BG566964 AI807430 AI676072 AA837010 AI452482 AI625817 AW241750 BE048616 AI290928 AI680714 AA485530 BE175687 AV648513 AW130312 AI000556 AA632893 BE674169 BF001208 AA948166 BE175650 AA524664 AA490345 AI244948 AA602956 AA483492 AA918178 AW802049 BG675859 AV658871 BG678060 AI5650O4 AW819026 BE843092 AV686437 AV723049 BG616948 AI911647 AI743490 AI091096 BE857251 AI962074 AA040027 AW769317 AA343477 AA640112 BF876213 R82948 H26425 H82876 BE843095 BE843140 BG536641 BG617830 AA235802 BE774985 BE006682 BF342375 AA903144 BF338083 BF984258 AV657996 AI749532 BE768614 BE857252 BE932516 BE768573 AV657993 AV657777 AV752631 BE774974 T55847 BF095761 BF911511 BE710793 BE180119 BG617338 H45942 T55897 AV657718 BG563497
450515 13638.2 BE299605 AI589870 AA847598 AI470122 BF939896 AI304356 BE223045 BF435800 AI394207 AI708171 AW025415 AI079409 AW008420 AW304226
N34543 AW603578 AA526961 AA983631 N99134 AA626645 R45023 AA902417 AW672925AA449985 AA953982 AW675471 AA010062 N80194 H14620 H28475 H26247 BF333581 AW842369 H06848 H05608 H81745 H15016 R51905 AA860423 AI860904 AA876023
406782 0.0 AA430373 AA968771
426143 3806 1 BC005265 BG176720 AW006027 BM352064 AW026316 AI635822AI880584 AI693769 AI092211 BI492387 AI400449 AW166297 BF939910 AA232282
AW021432 AI333893 AA494308 AA854899 AI436795 AW069256 AA682373 AI092748 AA993184 AH 26077 AI081758 AI240686 AI261863 AI378423 AA465237 AI376096 AA035579 AI087306 AA448162 AA129977 AI090903 AI080686 AI288939 N33004 AI801240 AW021546 AI370773 AI086064 AA669528 AI250053 AI870113 AA853181 AA85801 BG055562 BG939559 AW080765 AA032283 AW467587 H40506 D00762 NM.002788 AA641134 AI582295 AI417525 AI563975 AI093566 AI707743 AI290741 AW073417 BE875418 BM264076 BG876884 AI680535 AW854219 BE774635 AW854212 BG952443 AW854221 AW854208 BE156348 BE843056 AW858991 BE937569 BG878291 BG876450 AW819099 AI908570 AA449871 AU135228 BM478404 BF126296 AA375499 AA248473
400223 2368 1 NM.005648 BC013809 L34587 BF103775 BG702618 BG716553 BI667090 BG505863 BF983483 BG718195 BI857891 BG501016 BM043599
AL521812 BG705730 BI495545 BI495546 BF112248 BM023182 BM023123 AI075173 AW051799 BF058224 BI324885 BF436008 AA398446 BG822375 BM019558 BM023382 BG164174 N56909 BI467064 BM023464 AI207475 BM311415 BG758430 BG758807 AI934826 N90351 BG422026 BE910312 AI027778 AI081950AI360890 BM009115AI191829 BG759697 AI138728 AA399403 AI355589 AI336427 AA868702 AA393660AA025127 BG027630 AA962774 AA631224 BG940967 BE791087 AA573315 W81685 AA393525 BG944103 AI339125 Al 149864 AA977655 N90314 BE612839 BG491847 AI129091 AA461234 AA781198 AA759256 AA888954 AA97S844 AI184099 AI018O25 AA398363 AI003331 AI193380 AA626020 AI244476 AI601114 AW135664 AI206607 AW263599 AA813219 AI6B4453 AA878626 AA772222 AI085496 AI630226 BG940966 AI022010 AA770649 AA887624 AA491739 AA974295 BG530040 AA037091 AA019912 BI160457 H64512 BG503896
427239 20459 2 AL532360 BE794750 AA582906 AI015067 AW271034 BG271636 AW075177 AW071374 AI345565 AI307208 BE138953 BE049086 AI334881
AW075006 AW075181 AA464019 AW302733 AW075100 AW073433 AI802854 AI334909 AI802853 AI345036 AI348921 AI340734 AI307478 AI251289 AW302327 AW072520 AI312145 AW073656 AW072513 AW071289 AI307559 AA876186 T29587 AI307493 AI255068 AI252868 AI252839 AW074809 AI252926 AI252160AI251662 AI251262 AI610913AI270787 AI270156 AI252075AW073469 AW072901 AW072496AW071420 AI305762AI254764 AI802837 AI251264 AW073049 AW071311 AI340643 BE138965 BE138502 AW073456 AI334733 AI054335 BE139260 AI054302 AI054060 AI054057 AI053722 AI289711 BE139228 AW470478 AW271039 AW302085 BE041872 AI254494 AI271496 AI252427 BF718773 BF718645 AW074866 BE857822
TABLE 56C
Pkey Unique number conesponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publication endtled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predided NLposidon Indicates nucleotide posidons of predicted exons
Pkey Ref Strand Nt position
404854 7143420 Plus 14260-14537
405506 6466489 Plus 80014-80401,8059581125
402474 7547175 Minus 5352553628,5575555920,5753557757
TABLE 57A ABOUT 304 GENES UPREGULATED IN MELANOMA METASTASES RELATIVE TO NORMAL SKIN
Table 57A lists about 304 genes upregulated in melanoma metastases reladve to nomial skin Genes were selxted from 59680 probesets on the Eos/Affymetnx Hu03 Genxhip anay Gene expression data for exh probeset obtained from this analysis was expressed as average intensity (Al), a nomialized value reflxdng the reladve level of mRNA expression
Pkey Unique Eos probeset idendfier number
ExAxn Exemplar Axession number. Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dtle
R1 90th percendle of melanoma metastasis Als divided by the 90th percendle of normal skin Als
R2 90th percendle of melanoma metastasis Als divided by the 90th percendle of nomial skin Als, where the 15th percendle of normal dssue Als was subtrxted from both the numerator and denominator
Pkey ExAccn UnigenelD Unigene Title R1 R2
422424 AI186431 Hs 296638 prostate differentiation fxtor 1894 2500
438549 BE386801 Hs 21858 tπnudeotide repeat containing 3 1745 1847
417880 BE241595 Hs 82848 selxdn L (lymphxyte adhesion molxule 1405 11 15
452838 U65011 Hs 30743 preferentially expressed andgen in mela 1391 1541
446619 AU076643 Hs 313 sxreted phosphoprotein 1 (osteopondn, 1341 973
426555 NM.000372 Hs 2053 tyrosinase (xulxutaneous albinism IA) 12 24 7 33
439310 AF086120 Hs 102793 ESTs 10 12 1080
414020 NM.002984 Hs 75703 small inducible cytokine A4 (homologous 974 10 16
447210 AF035269 Hs 17752 phosphatidylsenne-spxific phospholipas 943 11 69
414812 X72755 Hs 77367 monok e induced by gamma interferon 9 28 1097
430377 NM 001922 Hs 301865 dopxhrome tautomerase (dopxhrome delta 907 796
426600 NM.O03378 Hs 171014 VGF nerve growth fxtor inducible 906 1993
453857 AL080235 Hs 35861 DKFZP586E1621 protein 866 587
418310 AA814100 Hs 86693 ESTs 865 662
433447 U29195 Hs 3281 neuronal pentraxm II 8 27 468
430280 AA361258 Hs 237868 interieukin 7 rxeptor 801 637
430822 AJ005371 Hs 248017 glyceraldehyde-5phosphate dehydrogenase 7 80 6 10
456373 BE247706 Hs 89751 membrane-spanning 4^domaιns, subfamily A 7 78 760
415752 BE314524 Hs 78776 putative transmembrane protein 768 541
419628 H67546 Hs 49768 ESTs 7 66 896
417355 D13168 Hs 82002 endothelin rxeptor type B 7 56 459
424321 W74048 Hs 1765 lymphxyte-spxitic protein tyrosine km 748 577
412228 AW503785 Hs 73792 complement component (3d/Epsteιn Ban vi 7 43 493
435485 X59135 Hs 156110 immunoglobulin kappa constant 735 798
414646 AA353776 Hs 901 CD48 antigen (8-cell membrane protein) 697 506
422241 Y00062 Hs 170121 protein tyrosine phosphatase, receptor t 683 520
429170 NM 001394 Hs 2359 dual spxificity phosphatase 4 6 67 377
417542 J04129 Hs 82269 progestagen-ass∞iated endometπal prote 667 15 22 428398 AI249368 Hs 98558 ESTs 657 360
408989 AW361666 Hs 49500 KIAA0746 protein 648 493
417022 NM.014737 Hs 80905 Ras assxiadon (RalGOS/AF-6) domain fam 638 365
449644 AW960707 Hs 148324 ESTs 635 584
412326 R07566 Hs 73817 small inducible cytokine A3 (homologous 630 7 18
457211 AW972565 Hs 32399 ESTs Weakly similar to S51797 vasodilat 625 721
420991 AW504814 Hs 287379 Homo sapiens mRNA for FU00111 protein, 625 536
428227 AA321649 Hs 2248 small inducible cytokine subfamily B (Cy 6 18 601
432828 AB042326 Hs 287402 chondroidn 4-sulfotransferase 6 12 651
449078 AK001256 Hs 22975 KIAA1576 protein 605 855
436856 AI469355 Hs 127310 ESTs 600 554
433658 L03678 Hs 156110 immunoglobulin kappa ∞nstant 592 7 18
424247 X14008 Hs 234734 lysozyme (renal amyloidosis) 589 407
409417 AA156247 Hs 104879 senne (or cysteine) proteinase inhibito 586 607
431574 AW572659 Hs 261373 hypothetical protein dJ4340143 574 603
458079 AI796870 Hs 54277 DNA segment on chromosome X (unique) 992 572 592
440274 R24595 Hs 7122 scrapie responsive protein 1 569 3 22
429412 NM 006235 Hs 2407 POU doman, class 2, assxiadng fxtor 569 5 17
432606 NM 002104 Hs 3066 granzyme K (senne protease, granzyme 3, 568 335
436315 BE390513 Hs 27935 hypothetical protein MGC4837 567 4 56
452973 H88409 Hs 40527 ESTs 563 550
426559 AB001914 Hs 170414 paired basic ammo xid cleaving system 562 309
406663 U24683 immunoglobulin heavy constant mu 554 968
416975 NM 004131 Hs 1051 granzyme B (granzyme 2, cytotoxic T-lymp 552 642
408380 AF12305O Hs 44532 diubiquidn 551 449
418299 AA279530 Hs 83968 integnn, beta 2 (andgen CD18 (p95), ly 543 450
429500 X78565 Hs 289114 hexabrxhion (tenascin C, cytotacdn) 542 3 54
446341 AL040763 Hs 310735 ESTs, Moderately similar to ALU7.HUMAN A 541 529
425234 AW152225 Hε 165909 ESTs, Weakly simila to I38022 hypothed 540 435
434203 BE262677 Hs 283558 hypothedcal protein PR01855 538 4 16
420338 AA825595 Hs 88269 Homo sapiens clone MGC 17339 mRNA, com 537 577
430580 AA806105 Hs 300697 immunoglobulin heavy constant gamma 3 (G 531 532
428804 AK000713 Hs 193736 hypothetical protein FU20706 529 480
447735 AA775268 HS 6127 Homo sapiens cDNA FU23020 fis, clone L 529 361
410491 AA465131 Hs 64001 Homo sapiens clone 25218 mRNA sequence 527 535
410361 BE391804 Hs 62661 guanylate binding protein 1, iπterferon- 526 600
412561 NM 002286 Hs 74011 lymphxyte-xtivadon gene 3 526 504
450293 N36754 Hs 171118 hypothetical protein FU00026 523 360
400750 Target Exon 5 18 362
417933 X02308 Hs 82962 thymidylate synthetase 5 14 333
413385 M34455 Hs 840 indoleamme-pyrrole 2,3 dioxygenase 5 12 536
445784 Al 253155 Hs 146065 ESTs 5 12 406
420602 AF060877 Hs 99236 regulator of G-protem signalling 20 506 768
421508 NM.004833 Hs 105115 absent in melanoma 2 503 5 59
434826 AF155661 Hs 22265 pyruvate dehydrogenase phosphatase 496 625
402474 NM.004079 Homo sapiens cathepsin S (CTSS 495 5 13
400417 X72475 Target 490 393
420137 AA306478 Hs 95327 CD3D antigen, delta polypepdde (TιT3 co 488 681
409264 NM.014937 Hs 52463 KIAA0966 protein 488 3 18
418460 M26315 Hs 85258 CD8 andgen, alpha polypepdde (p32) 487 420
418506 AA084248 Hs 85339 G protein-∞upled rxeptor 39 485 586
409142 AL136877 Hs 50758 SMC4 (structural maintenance of chromoso 483 594
425088 AA663372 Hs 169395 hypothetical protein FU12015 482 5 19
405506 Target Exon 474 409
409512 AW979187 Hs 293591 melanoma differendadon assxiated prot 474 3 72
430838 N46664 Hs 169395 hypothetical protein FU12015 473 350
439963 AW247529 Hs 6793 platelet-activating fxtor xetylhydrola 472 366
421379 Y15221 Hs 103982 small inducible cytokine subfamily B (Cy 471 5 16
447217 BE465754 Hs 17778 neuropilin 2 470 452
422309 U79745 Hs 114924 solute earner family 16 (monxarboxylic 469 3 51
413670 AB000115 Hs 75470 hypothetical protein, expressed in osteo 468 369
419956 AL137939 Hs 40096 cadhenn 19, type 2 468 583
429903 AL134197 Hs 93597 cyclm-dependent kinase 5, regulatory su 468 529
449217 AA278536 Hs 23262 nbonuclease, RNase A family, k6 466 384
449722 BE280074 Hs 23960 cyclm B1 464 429
424006 AF054815 Hs 137548 CD84 antigen (leukxyte antigen) 462 4 54
407846 AA426202 Hs 40403 Cbp/p300-ιnterxtιng traπsxtivator, wit 462 678
414821 M63835 Hs 77424 Fc fragment of IgG high affinity la, re 459 581
406673 M34996 Hs 198253 maior histocompadbility complex, class 457 560
431620 AA126109 Hs 264981 2-5'-olιgoadenylate synthetase 2 (69-71 456 444
441224 AU076964 Hs 7753 calumemn 456 375
442739 NM.007274 Hs 8679 cytosolic xyl coenzyme A thioester hydr 4 56 322
444371 BE540274 Hs 239 fortøiead box M1 453 5 28
448719 AA033627 Hs 21858 tπnucleotide repeat containing 3 448 908
420301 AA767526 Hs 22030 paired box gene 5 (B-cell lineage spxif 447 561
430294 AI538226 Hs 32976 guanine nucleotide binding protein 4 443 4 11
428513 BE220806 Hs 184697 Homo sapiens clone 23785 mRNA sequence 441 443
446006 NM 004403 Hs 13530 deafness, autosomal dommait 5 4 39 399
432485 N90866 Hs 276770 CDW52 andgen (CAMPATH-1 antigen) 438 5 50
428242 H55709 Hs 2250 leukemia inhibitory fxtor (cholmergic 437 325
421633 AF121860 Hs 106260 sorting nex 10 4 36 6 23
414829 AA321568 Hs 77436 plxkstnn 4 35 291
417166 AA431323 Hs 42146 ESTs 435 408 448410 AK000227 Hs 21126 hypothetical protein FU20220 434 5 35
419381 AB023420 Hs 90093 heat shxk 70kD protein 4 434 372
411305 BE241596 Hs 69547 myelin basic protein 432 4 18
425289 AW139342 Hs 155530 interferon, gamma-mducible protein 16 4 28 244
451099 R52795 Hs 25954 interieukin 13 rxeptor, alpha 2 427 448
432642 BE297635 Hs 3069 heat shxk 70kD protein 9B (mortalιn-2) 4 25 269
422282 AF019225 Hs 114309 apolipoprotein L 4 25 375
433867 AK000596 Hs 3618 hφpxalcin-like 1 423 5 13
415817 U88967 Hs 78867 protein tyrosine phosphatase, receptor-t 420 215
438619 AB032773 TU12B1-TY protein 419 332
426317 AA312350 Hs 169294 transcnpdon fxtor 7 (T-cell spxific, 4 16 5 14
420208 BE276055 Hs 95972 silver (mouse homolog) like 416 508
416602 NM.006159 Hs 79389 Protein kinase C-bindmg protein NELL2 4 16 238
430770 AA765694 Hs 123296 ESTs 4 15 367
424541 AW392551 Hs 180559 ESTs, Weakly simila to A56194 thromboxa 4 15 398
427337 Z46223 Hs 1 6663 Fc fragment of IgG, low affinity lllb, r 4 14 351
456760 AW961251 Hs 127828 guanine nudeodde binding protein (G pr 4 14 442
406868 AA505445 Hs 300697 immunoglobulin heavy constant gamma 3 (G 413 507
420931 AF044197 Hs 100431 small inducible cytokine B subfamily (Cy 4 12 643
410016 AA297977 Hs 57907 small inducible cytokine subfamily A (Cy 4 11 873
452698 NM 001295 Hs 301921 chemokine (C-C modf) rxeptor 1 411 448
444863 AW384082 Hs 104879 senne (or cysteine) proteinase inhibito 4 10 478
435080 AI831760 Hs 155111 hypothedcal protein FU 14428 407 276
442711 AF151073 Hs 8645 hypothedcal protein 406 349
423605 AF047826 Hs 129887 cadhenn 19, type 2 406 242
409038 T97490 Hs 50002 small inducible cytokine subfamily A (Cy 405 326
421712 AK000140 Hs 107139 hypothetical protein 402 760
422283 AW411307 Hs 114311 CDC45 (cell division cyde 45, S cerevis 400 387
409415 AA579258 Hs 6083 Homo sapiens cDNA FU21028 fis, ctone C 400 587
412719 AW016610 Hs 816 ESTs 399 546
437179 AA393508 serotogically defined colon cancer andg 396 4 51
420319 AW406289 Hs 96593 hypothedcal protein 395 547
438380 T06430 Hs 6194 chondroidn sulfate proteoglycan BEHAB/b 391 458
418064 BE387287 Hs 83384 SlOOcalcium-bmding protein beta (neur 384 442
420286 AI796395 Hs 111377 ESTs 383 456
410600 AW575742 ESTs, Moderately similar to S65657 alpha 380 570
410326 AI368909 Hs 47650 ESTs 376 486
424779 AL046851 Hs 153053 CD37 andgen 370 872
452194 AI694413 Ubiquidn-like protein FAT10'-" - diubiq 369 638
411027 AF072099 Hs 67846 leukxyte immunoglobulin-like rxeptor, 365 540
412140 AA219691 Hs 73625 RAB6 interxdng kinesm-like (rabkmes 365 448
424153 AA451737 Hs 141496 MAGE-like 2 364 582
421666 AL035250 Hs 1408 endothelin 3 364 552
429732 U20158 Hs 2488 lymphxyte cytosolic protein 2 (SH2doma 360 556
422173 BE385828 Hs 250619 phorbolin-like protein MDS019 (CEM15) 359 435
421563 NM 006433 Hs 105806 granulysm 349 738
453837 AL138387 Hs 256126 bxuloviral IAP repeat-contemiπg 7 (liv 349 6 13
424326 NM.014479 Hs 145296 ADAM-like dismtegnn protease dxysm 348 4 23
427247 AW504221 Hs 174103 integnn, alpha L (andgen CD11A (p180), 347 538
408838 AI669535 Hs 40369 ESTs 345 459
402829 C1002500 gι|6754254|ref|NP_034610 11 hea 342 501
418918 X07871 Hs 89476 CD2 antigen (p50), sheep red blood cell 342 8 14
430594 AK000790 Hs 246885 hypothedcal protein FU 20783 340 4 35
429714 BE561801 Hs 2484 T-cell leukemia/lymphoma 1A 336 484
414324 Y14768 Hs 890 lymphotoxin beta (TNF superfamily, membe 335 445
421958 AA357185 Hs 109918 ras homolog gene family, member H 335 428
428291 AA534009 Hs 183487 interferon stimulated gene (20kD) 334 5 18
424687 J05070 Hs 151738 matπx metalloproteinase 9 (geladnase B 331 800
451736 AW080356 Hs 23889 ESTs, Weakly simila to ALU7.HUMAN ALU S 329 450
412790 NM.014767 Hs 74583 KIAA0275 gene product 328 542
404854 Target Exon 328 428
400860 Target Exon 326 441
430413 AW842182 Hs 241392 small inducible cytokine A5 (RANTES) 3 24 565
438209 AL120659 Hs 6111 aryl-hydrxarbon receptor nuclear transl 324 435
422846 BE513934 Hs 1583 neutrophil cytosolic fxtor 1 (47kD, chr 324 490
440065 W03476 Hs 266331 hypothetical protein MGC4595 320 621
440704 M69241 Hs 162 msulm-like growth fxtor binding prote 320 472
411088 BE247593 Hs 145053 ESTs 3 18 420
447513 AW955776 Hs 313500 ESTs Moderately simila to ALU7.HUMAN A 318 468
413190 AA151802 Hs 40368 adaptor-related protein complex 1 , sigma 315 4 27
430017 AA263172 Hs 35 protein tyrosine phosphatase, non-rxept 315 428
406837 R70292 Hs 156110 immunoglobulin kappa constant 3 12 409
409103 AF251237 Hs 112208 XAGE-1 protein 304 404
425706 AW406678 Hs 122559 hypothedcal protein FU22570 304 4 28
447656 NM 003726 Hs 19126 src kmase-assxiated phosphoprotein of 303 430
427792 M63928 Hs 180841 tumor nxrosis fxtor rxeptor superfami 301 482
402994 NM.002463" Homo sapiens myxovirus (influ 299 574
434276 AF123659 Hs 93605 leucine zipper, putadve tumor suppresso 297 507
449523 NM 000579 Hs 54443 chemokine (C-C modf) rxeptor 5 296 15
439237 AW408158 Hs 318893 ESTs, Weakly similar to A47582 B-cell gr 296 581
406621 X57809 Hs 8997 immunoglobulin lambda Ixus 293 788
447131 NM 004585 Hs 17466 retinoic xid rxeptor responder (tazao 291 13 22
426322 J05068 Hs 2012 transcobalamm I (vitamin B12 binding pr 290 8 37 448275 BE514434 Hs 20830 kinesm-like 2 287 4 15
423397 NM 001838 Hs 1652 chemokine (C-C modf) rxeptor 7 286 553
406782 AA430373 gb zw20f11 s1 Soaes ovary tumor NbHOT H 281 460
414915 NM 002462 Hs 76391 myxovirus (influenza) resistance 1. homo 280 589
412819 T25829 Hs 24048 FK506 binding protein precursor 278 490
432886 BE159028 Hs 279704 chromatin xcessibi ty ∞mplex 1 276 421
428380 NM.004271 Hs 184018 MD-1, RP105assxιated 276 5 15
408209 NM 004454 Hs 43697 ets variant gene 5 (ets-related molxule 276 430
416511 NM.006762 Hs 79356 Lysosomal-assxiated muldspanπmg membr 275 4 13
422530 AW972300 Hs 118110 bone marrow stromal cell andgen 2 274 505
428746 AW503820 Hs 192861 Spi-B transcnptoon fxtor (Spι-1/PU 1 r 273 920
453953 AW408337 Hs 36972 CD7 andgen (p41) 272 438
407241 M34516 gb Human omega light chan protein 14 1 268 407
437669 AI358105 Hs 123164 ESTs, Weakly similar to match to ESTs AA 266 471
453779 N35187 Hs 43388 28kO interferon responsive protein 265 431
432874 W94322 Hs 279651 melanoma inhibitory xdvity 264 4 15
410129 BE244074 Hs 58831 regulator of Fas-induced apoptosis 262 736
412926 AI879076 Hs 75061 xrophage myπstoylated alanine-πch C 262 443
418739 AA310964 Hs 88012 SHP2 interxdng transmembrane adaptor 261 542
424825 AF207069 Hs 153357 procollagen-lysine, 2-oxoglutarate 5-dιo 260 969
417370 T28651 Hs 82030 liγptophanyl-tRNA synthetase 260 5 17
411358 R47479 Hs 94761 KIAA1691 protein 259 401
425367 BE271188 Hs 155975 protein tyrosine phosphatase, receptor t 258 1324
426470 AA528794 Hs 128644 ESTs 254 452
425535 AB007937 Hs 158287 KIAA0468 gene product 252 11 31
431629 AU077025 Hs 265827 interferon, alpha-inducible protein (do 250 780
425722 AI659076 Hs 97031 hypothedcal protein MGC13047 249 4 25
438291 BE514605 Hs 289092 Homo sapiens cDNA FU22380 fis, clone H 249 404
416426 AA180256 Hs 210473 Homo sapiens cDNA FU14872 fis, clone PL 248 408
441859 AW194364 Hs 94814 ESTs. Weakly simila to FIG1 MOUSE FIG-1 248 525
416714 AF283770 Hs 79630 CD79A antigen (immunoglobulin-assxiated 248 488
431186 NM.012249 Hs 250697 ras-like protein 246 604
417389 BE260964 Hs 82045 midkine (neuπte growth-promoting fxtor 245 534
424481 R19453 Hs 1787 proteolipid protein 1 (Pe zaeus-Merzbx 243 657
428437 AV656017 Hs 184325 CGI-76 protein 242 496
427634 AI399745 Hs 18449 hypothetical protein MGC10820 2 39 846
420842 AI083668 Hs 50601 hypothedcal protein MGC10986 238 590
428289 M26301 Hs 2253 xmplement component 2 238 5 32
417929 R27219 Hs 74647 Human T-cell rxeptor xdve alpha-chan 237 699
413278 BE563085 Hs 833 interferon-sdmulated protein, 15 kDa 234 969
433671 AW138797 Hs 132906 19A24 protein 234 481
432403 AA550815 Hs 124840 ESTs 234 499
427759 BE245578 Hs 2200 perfoππ 1 (pore forming protein) 232 456
419870 AW403911 Hs 266175 phosphoprotein assxiated with GEMs 230 422
421445 AA913059 Hs 104433 Homo sapiens, clone IMAGE 4054868 mRNA 230 6 18
401591 Target Exon 229 701
451708 AI306536 Hs 60975 ESTs 2 26 450
452700 AI859390 Hs 288940 five-span transmembrane protein M83 224 490
424618 L29472 Hs 1802 maior histocompatibility complex, class 222 540
409208 Y00093 integnn, alpha X (andgen CD11 C (p150), 2 21 474
436456 AW292677 Hs 248122 G protein-coupled rxeptor 24 2 19 461
419741 NM 007019 Hs 93002 ubiquitin earner protein E2-C 2 17 7 43
416448 L13210 Hs 79339 Ixdn galxtoside-binding, soluble, 3 2 16 558
438555 AI222089 Hs 143878 Homo sapiens mRNA for FU00024 protein, 2 13 426
407260 L09095 gb Homo sapiens mRNA fragment 2 13 400
448243 AW369771 integnn, beta 8 2 10 403
437938 AI950087 gb wq05c02 x1 NCI_CGAP_Kid12 Homo sapien 207 445
425262 D87119 Hs 155418 GS3955 protein 206 436
414945 BE076358 Hs 77667 lymphxyte andgen 6 complex, Ixus E 205 466
400261 Eos Control 204 422
432468 AW402155 Hs 3003 CD3E antigen, epsilon polypeptide (TιT3 202 4 23
416967 BE616731 Hs 80645 interferon regulatory fxtor 1 1 99 445
420626 AF043722 Hs 99491 RAS guanyl releasing protein 2 (calcium 1 98 442
440672 AF083811 Hs 7345 MAD1 (mitodc arrest deficient, yeast, h 1 98 4 55
452923 BE276018 Hs 288940 five-span transmembrane protein M83 1 96 454
452244 N33530 Hs 176674 ESTs 1 95 4 23
427239 BE270447 ubiquitin earner protein 1 94 4 93
418678 NM.0O1327 Hs 167379 cancer/tesds antigen (NY-ESO-1) 1 94 5 28
431836 AF178532 Hs 271411 beta-site APP-cleaving enzyme 2 1 93 4 17
444090 S69115 Hs 10306 natural killer cell group 7 sequence 1 93 506
404067 Target Exon 1 92 6 16
426890 AA393167 HS 41294 ESTs 1 91 4 23
453597 BE281130 Hs 33713 myo- ositol 1-phosphate synthase A1 1 91 4 10
401914 Target Exon 1 87 476
448499 BE613280 Hs 77550 hypothetical protein MGC1780 1 87 5 17
439627 BE621702 Hs 29076 hypothedcal protein FU21841 1 85 659
425923 NM 005026 Hs 162808 phosphoιnosιtιde-3-kιnase, catalytic, de 1 85 4 03
416819 U77735 Hs 80205 pιm-2 oncogene 1 84 4 57
425069 AA687465 Hs 298184 potassium voltage-gated channel, shaker- 1 84 640
430378 Z29572 Hs 2556 tumor nxrosis fxtor receptor superfami 1 78 402
435968 AW161481 Hs 111577 integral membrane protein 3 1 76 526
410423 AW402432 Hs 63489 protein tyrosine phosphatase, noπ-rxept 1 75 4 30
434224 AA380731 Hs 84 interieukin 2 receptor, gamma (severe co 1 74 491 413566 AW604451 Hs 285814 sprouty (Drosophila) homolog 4 1 71 600
430148 BE387620 Hs 234489 Ixtate dehydrogenase B 1 70 434
410068 AI633888 Hs 58435 FYN-bffldmg protein (FYB-120/130) 1 69 404
437696 Z83844 Hs 5790 hypothedcal protein dJ37E165 1 66 595
423984 AF163825 Hs 136713 pre-8 lymphxyte gene 3 1 64 626
426666 AW500131 Hs 171763 CD22 andgen 1 63 4 33
406908 Z25437 gb H sapiens protem-tyrosine kinase gen 1 62 7 19
440087 W28969 Hs 7718 hypothetical protein FU22678 1 61 433
421859 AA356620 Hs 108947 KIAA0050 gene product 1 59 430
415198 AW009480 Hs 943 natural killer cell tranxπpt 4 1 56 4 12
406827 AA971409 gb op92c04 s1 NCI_CGAP_Lu5 Homo sapiens 1 55 429
413969 X14034 Hs 75648 phospholipase C, gamma 2 (phosphaddylin 1 53 463
456086 AL161999 Hs 77324 eukaryodc translation termination fxto 1 52 411
433320 D60647 Hs 250879 ESTs, Highly similar to CTXN RAT CORTEXI 1 52 436
406906 Z25424 gb H sapiens protein-senne/threonine ki 1 50 867
406885 D28423 gb Human mRNA for pre-mRNA splicing fxt 1 49 507
443759 BE390832 Hs 134729 FXYD domain-containing ion transport reg 1 48 450
452423 AA991724 Hs 180535 hypothedcal protein MGC10966 1 48 491
448143 AF039704 Hs 20478 ceroid-lipofuxinosis, neuronal 2, late 1 43 426
451524 AK001466 Hs 26516 hypothedcal protein FU 10604 1 43 474
417287 AI831678 Hs 285714 KIAA1599 protein 1 41 401
432665 AW603880 ATPase, H transporting, lysosomal (vxuo 1 38 407
403043 Target Exon 1 36 489
407239 AA076350 Hs 67846 leukocyte immunoglobulm-like rxeptor, 1 32 457
436553 AW407157 Hs 8997 immunoglobulin lambda Ixus 1 30 400
422934 BE244189 Hs 122492 hypothedcal protein 1 30 437
442680 BE270707 Hs 8583 simila to APOBEC1 1 26 448
TABLE 57B
Pkey Unique Ex probeset idendfier number
CAT number Gene cluster number
Axession Genbank axession numbers
Pkey CAT Number Accession
438619 35124.1 NM.016575 AB032773 AI765521 BF593742 AI497757 AI761233 AV
AH 47248 AI086795 AA15131 T95298 AW083548 AA058371 N27951 AI769860 AI784548 A 205506 A!800679 AI041733 A1459902 BE327641
AI865829 AI254736 AI302433 AI744176 AI241825 AA027842 AL524933 AL524932 BF947764 BF340737 BF948700 BG996395 N53455 N21027 AI127616 N35901 AA682443 AA678249 AA719371 AA132582 T15981 H99958 N40717 AW959402 AI267251 BF909329 AI142035 T95379 H29420 R59632 H17318 H17331 H29327 R40829 R43395 R59573 AI749561 R56599 H16755 AI694500 AA027907
437179 12239.1 AK055109 BC019085 AA187684 BG656226 BM023227 AI932311 AW264381 AA398371 BM021483 AI432433 AI375777 AI129580 AW262782
AA134107 BM023515 AA977504 AI859222AI348454 R69725 AA975268 BM021207 AL080074AA129218 AW207842 N90581 AA771919 AI092259 AI028416 AI074114 BG656536 BE501677 AW193419 AA917040 W90430 AI342984 AI378957 AL036486 AW020068 BI491093 BF476021 R41226 R69631 F04125 C02343 AA115589 R56480 AI400988 R54266 R31422
410600 497855.1 BF347859 AW499616 AA191322 AW499617 AL601010 AW575742 AA729043 BE463447 AA086179 BE549623 AI335824 AW408712 BM149172
452194 90339.1 AI694413 AW994700 AI912946 N73548 AI082035 AW271652 W24189 W24182 AI719718 AA024658 AW810120 AW015394 T79755 AA988043
AI709339
406782 0 0 AA430373 AA968771
409208 10117.2 AK074047 AI144342AW014280 BM145128 N28267 AW206231 AA989041 H93197 AW594063 BG236296 AW236606 AW081031 AA765843 BM144372
AA989341 AI824838 AI963970 AI637671 AW196330 BG427526 BM148789 BF893644 BF881946
448243 13061.2 BG166513 AA479726 BE622314 AL134913 BE006305 BE006312 BE006298 AA044582 AW994956 AA234175 AA043906 BE006303 BF327669
BE006317 BF326759 BF541959
437938 66997.1 U71456 AA482911 W78802 AW856538 BF737212 N36809 N35320 AA282915 AW505512 AI653832 W87891 AI961530 T85904 H59397 R97278
W01059 AI820532 T82391 AI820501 T63226 R66056 R67840 AW961101 AA337499 W37181 AA180009 AW205862 AA988777 AA856975 BF172457 BG751124 AI741346 AI950344 AI689062 AI872193 AW102898 AW173586 AI763273 AI890387 AW150329 AI762688 AA488892 AI356394 AI539642 AA642789 AI950087 BF589902 N70208 AA283144 AA488964 H60052 R97040 BF886630 AW967677 AW971573 AW967671 AI308119 AA251875 AA908598 AI819225 AI564269 AA908741 AA293273 AA969759 AW276905 AA044209 H83488 T92487
400261 23110.1 BC006097 X03066 NM.O02120 M26040 AW469119 AW469127 AI299772 AW518149 Al 144456 AW628070 AI629032 AI358810 AI880433 AI440472
AI357070 AI865365 AW014799 AI767973 AW518041 AA909398 AW768606
427239 20459.2 AL532360 BE794750 AA582906 AI015067 AW271034 BG271636 AW075177 AW071374 AI345565 AI307208 BE138953 BE049086 AI334881
AW075006 AW075181 AA464019 AW302733 AW075100 AW073433 AI802854 AI334909 AI802853 AI345036 AI348921 AI340734 AI307478 AI251289 AW302327 AW072520 AI312145 AW073656 AW072513 AW071289 AI307559 AA876186 T29587 AI307493 AI255068 AI252868 AI252839 AW074809 AI252926 AI252160 AI251662 AI251262 AI610913 AI270787 AI270156 AI252075 AW073469 AW072901 AW072496 AW071420 AI305762 AI254764 AI802837 AI251264 AW073049 AW071311 AI340643 BE138965 BE138502 AW073456 AI334733 AI054335 BE139260 AI054302 AI054060 AI054057 AI053722 AI289711 BE139228 AW470478 AW271039 AW302085 BE041872 AI254494 AI271496 AI252427 BF718773 BF718645 AW074866 BE857822
406827 0.0 AA971409
432665 27095.3 BG165971 BE143233 AL577712 AI400326 AA769318 AA427866AW088714 AI150755 AI924874 Al 186243 AA804195 AA768972 AW574769
AW341643 AW204520 AA235326 AI005076 BE826687 AW004816 AW0O7235 BE826639 BE826634 BF222941 BE826631 BE826643 AA292639 AW514133 AI690331 AI673409 AA627727 AI923685 AA931499 AI249783 AI810663 AA548622 AA702095 AA832395 BI259508 AA262993 AW075840 AA810885
TABLE 57C
Pkey Unique number conesponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column ae Genbank Idendfier (Gl) numbers "Dunham el al " refers to the publicadon entitled "The DNA sequence of human chromosome 22' Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposition Indicates nudeodde posidoπs of predicted exons
Pkey Ref Strand Nt position
400750 8119067 Plus 198991-199168,199315199548
402474 7547175 Minus 5352553628,5575555920,5753557757
405506 6466489 Plus 80014-80401,8059581125
402829 8918414 Plus 101532-101852,102005102263
404854 7143420 Plus 1426514537 400860 9757499 Minus 151830-152104,152649-152744
402994 2996643 Minus 4727-4969
401591 9966977 Minus 55410-55835
404067 3282162 Plus 14152071
401914 9369520 Plus 62537-62945,6315563308
403043 7768753 Minus 314425316252
TABLE 58A ABOUT 183 GENES UPREGULATED IN MELANOMA METASTASES FROM PATIENTS WITH LIMITED DISEASE RELATIVE TO MEUNOMA METASTASES FROM PATIENTS WITH PROGRESSIVE DISEASE
Table 58A lists about 183 genes upregulated in melanoma metastases from padents with limited disease reladve to melanoma metastases from padents with progressive disease Genes were selxted from 59680 probesets on the Eos/Affymetnx Hu03 Genxhip anay Gene expression data for exh probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflxdng the reladve level of mRNA expression Pkey Unique Eos probeset idendfier number
ExAxn Exempla Axession number, Genbank axession number
UnigenelD Unigene number
Unigene Title Unigene gene dde
R1 90th percendle of Als for metastases from padents with limited disease divided by 90th percenble of Als for metastases from padents with progressive disease
R2 90th percendle of Als for metastases from padents with limited disease divided by 90th percendle of Als for metastases from padents with progressive disease, where the 15th percendle of normal tissue Als was subtrxted from both the numerator and denominator
Pkey ExAxn UnigenelD Unigene Tide R1 R2
415668 AW957684 Hs 306814 hypothedcal protein FU21889 1274 1292
447414 D82343 Hs 74376 πeuroblastoma (nerve dssue) protein 766 588
412659 AW753865 Hs 74376 olfxtomedm related ER tocalized protei 723 576
430154 AW583058 Hs 234726 senne (or cysteine) proteinase inhibito 691 14 26
414430 AI346201 Hs 76118 ubiquitin carboxyl-terminal esterase L1 686 7 10
436485 X59135 Hs 156110 immunoglobulin kappa constant 685 681
426600 NM 003378 Hs 171014 VGF nerve growth fxtor inducible 673 11 21
430822 AJ005371 Hs 248017 glyceraldehyde-3-phosph ate dehydrogenase 553 463
416426 AA180256 Hs 210473 Homo sapiens cDNA FU14872 fis, clone PL 548 708
423858 AL137326 Hs 133483 Homo sapiens mRNA, cDNA DKFZp434B0650 (f 527 594
433658 L03678 Hs 156110 immunoglobulin kappa constant 478 307
452436 BE077546 Hs 31447 ESTs, Moderately similar to A46010 X-lm 468 327
413916 N49813 Hs 75615 apolipoprotein C-ll 4 62 482
407825 NM.006152 Hs 40202 lymphoid-restncted membrane protein 455 312
406648 AA563730 Hs 277477 major histocompadbility ∞mplex, class 431 4 15
409060 AI815867 Hs 50130 nxdm (mouse) homolog 423 344
401941 Target Exon 389 319
447471 AF039843 Hs 18676 sprouty (Drosophila) homolog 2 388 243
419628 H67546 Hs 49768 ESTs 366 416
414863 AW131473 Hs 106185 ral guanine nucleotide dissociation sdm 3 63 281
423416 NM.004920 Hs 128316 apoptosis-assxiated tyrosine kinase 347 306
400275 NM.006513* Homo sapiens seryl tRNA synth 347 343
426283 NM.003937 Hs 169139 kynurenmase (L-kynuremne hydrolase) 342 1 96
442117 AW664964 Hs 128899 ESTs, hypothedcal protein for IMAGE 447 341 2 89
411763 AW862589 gb QV5CT0387-180300-167-a07 CT0387 Homo 337 631
402007 C180O05O3* gι|8922165|ref|NP_060080 1| h 334 374
424775 AB014540 Hs 153026 SWAP-70 protein 3 30 200
424036 AA770688 H2A histone family, member L 330 3 16
453464 AI884911 Hs 32989 rxeptor (calcitonin) activity modifying 3 30 558
401739 NM.005622* Homo sapiens SA (rat hyperten 330 3 23
440274 R24595 Hs 7122 scrapie responsive protein 1 327 247
413398 D21262 Hs 75337 nucleolar and ∞iled-body phosphprotem 3 26 261
417165 R80137 Hs 302738 Homo sapiens cDNA FU21425 fis, clone C 326 258
418478 U38945 Hs 1174 cyclm-dependent kinase inhibitor 2A (me 3 14 404
436965 Z11894 Hs 156110 gb H sapiens reananged mRNA for immunog 313 2 38
453857 AL080235 Hs 35861 DKFZP586E1621 protein 3 13 247
404405 Target Exon 311 469
413719 BE439580 Hs 75498 small inducible cytokine subfamily A (Cy 3 11 2 10
443247 BE614387 Hs 333893 c-Myc target JP01 3 10 226
400417 X72475 Target 308 232
401512 NM_014080Ηomo sapiens dual oxidase-like 307 287
423242 AL039402 Hs 125783 DEME-6 protein 306 2 78
417501 AL041219 Hs 82222 sema domain, immunoglobulin doman (Ig) 306 281
451952 AL120173 Hs 301663 ESTs 305 265
427419 NM 000200 Hs 1 7888 histadn 3 305 4 24
406663 U24683 immunoglobulin heavy constant mu 305 455
442104 L20971 Hs 188 phosphodiesterase 4B, cAMP-spxific (dun 303 1 90
451993 AA765776 Hs 122983 ESTs 302 1 71
421097 AI280112 Hs 125232 Homo sapiens cDNA FU 13266 fis, clone OV 301 311
430129 BE301708 Hs 233955 hypothedcal protein FU20401 300 347
427700 AA262294 Hs 180383 dual specificity phosphatase 6 300 222
400237 NM.001087' Homo sapiens angio-assxiated 298 343
414063 H26904 Hs 75736 apolipoprotein D 297 5 76
426153 AF057169 Hs 182771 vitelliform mxular dystrophy (Best dise 294 238
414781 D50917 Hs 77293 KIAA0127 gene product 294 288
445823 AI478563 Hs 145519 FKSG87 protein 292 1 98
404439 ENSP00000067222* Mitxhondπal 28S πbos 292 2 57
421218 NM.000499 Hs 72912 cytxhrome P450, subfamily I (aromatic c 290 247
420350 AW406896 Hs 88269 Homo sapiens, clone MGC 17339. mRNA com 290 387
424855 AW204725 Hs 25560 ESTs 289 261
436700 AI693690 Hs 301406 hypothedcal protem PP3501 288 363 451131 AI267586 Hs 268012 fatty xid-Coenzyme A ligase, long-chan 287 292
427157 U51166 Hs 173824 thymine-DNA glycosylase 287 2 11
402273 Target Exon 287 248
414135 NM.004419 Hs 2128 dual spxificify phosphatase 5 283 309
430643 AW970065 Hs 287425 MEGF10 protein 283 304
451979 F06972 Hs 27372 endothelial tyrosine kinase (Etk) (BMX), 282 2 12
406642 AJ245210 gb Homo sapiens mRNA for immunoglobulin 281 288
407360 X13075 gb Human 2a12 mRNA for kappa-immunoglobu 281 343
405441 Target Exon 280 315
450816 BE271927 Hs 87385 ESTs 280 248
435675 AA694099 Hs 266820 ESTs 278 270
426495 NM.001151 Hs 2043 solute earner family 25 (mitxhondπal 278 253
441623 AA315805 desmoglem 2 278 227
413336 AI569936 Hs 296178 hypothedcal protein FU22637 276 318
408527 AL135018 Hs 33074 Homo sapiens, clone IMAGE 3606519, mRNA, 276 1 92
437740 AA810265 Hs 122915 ESTs 276 1 88
426322 J05068 Hs 2012 tranxobalamin I (vitamin B12 binding pr 275 806
411852 AA528140 Hs 107515 ESTs, Weakly similar to T00329 hypothed 274 330
428422 AI557280 Hs 184270 capping protein (xdn filament) muxle 273 231
426793 X89887 Hs 172350 HIR (histone cell cycle reguladoπ defx 272 219
401454 NM 014226* Homo sapiens renal tumor and 272 1 99
436825 AW341123 Hs 120275 ESTs 272 289
407705 AB023139 Hs 37892 KIAA0922 protein 272 248
416782 L35035 Hs 79886 nbose 5phosphate isomerase A (πbose 5 272 263
449151 AI632331 Hs 196038 ESTs 272 299
433464 N92481 gb zb12g02 s1 Soaes_fetal_lung_NbHL19W 269 317
401009 Target Exon 269 328
427227 AF103803 Hs 283690 hypothedcal protein 268 202
405268 ENSP00000223174* KIAA0783 PROTEIN 267 218
410295 AA741357 mdogen (enxdn) 265 206
435905 AW997484 Hs 5003 KIAA0456 protein 265 2 12
430378 Z29572 Hs 2556 tumor nxrosis fxtor rxeptor superfami 265 2 52
457423 AK000642 Hs 265018 hypothedcal protein FU 20635 264 251
448752 AA593867 Hs 300842 KIAA1608 protein 263 220
414931 AK000342 Hs 77646 Homo sapiens mRNA, cDNA DKFZp761M0223 (f 263 1 83
441283 AA927670 Hs 131704 ESTs 262 1 92
439352 BE614347 Hs 169615 hypothedcal protein FU20989 260 221
421391 AW304350 Hs 191958 immunoglobulin superfamily receptor tran 260 306
406678 U77534 gb Human clone 1 A11 immunoglobulin vana 254 306
430278 AI673074 Hs 116567 ESTs, Weakly similar to T22914 hypothed 249 344
425970 AK001500 Hs 165186 hypothetical protein FLJ13852 247 346
407363 AF035032 Hs 8997 gb Homo sapiens clone MCA1L myosm-rext 245 345
408367 AK001178 Hs 44424 homolog of rat orphan transporter v7-3 244 352
420103 AA382259 Hs 95197 aldehyde dehydrogenase 1 family, member 244 615
418635 L11329 Hs 1183 dual specificity phosphatase 2 242 392
451558 NM.001089 Hs 26630 ATP-bindmg cassette, sub-family A (ABC1 241 308
430354 AA9~54810 Hs 239784 human homolog of Drosophila Scribble 236 399
405701 ENSP00000004954" Adseveπn (Scindenn) 2 33 4 25
433427 AI816449 Hs 171889 cholinephosphotraπsferase 1 230 330
401965 CGI-148 protein 229 345
417866 AW0679O3 Hs 82772 collagen, type XI, alpha 1 223 407
428142 NM.001308 Hs 2246 carboxypepddase N, polypeptide 1, 50kD 219 317
422103 AA984330 Hs 111676 protein kinase H11, small stress protein 2 18 4 18
425746 NM.001701 Hs 159440 bile xid Coenzyme A ammo xid N-xylt 2 12 348
404835 NM.018943' Homo sapiens tubulin, alpha-l 209 572
401127 Target Exon 209 438
406161 Target Exon 208 322
421654 AW163267 Hs 106469 suppressor of val (S cerevisiae) 3-lιke 208 303
406632 AB006838 gb Homo sapiens mRNA for HRV Fab N31-VH, 207 325
447940 D86982 Hs 20060 KIAA0229 protein 205 480
411773 NM.006799 Hs 72026 protease, senne, 21 (tesdsin) 205 533
413211 AW967107 Hs 109274 hypothedcal protein MGC4365 202 474
425722 AI659076 Hs 97031 hypothedcal protein MGC13047 201 376
437044 AL035864 Hs 69517 differentially expressed in Fancom's an 1 96 527
436420 AA443966 Hs 31595 ESTs 1 94 368
414809 AI434699 Hs 77356 traπsfernn rxeptor (p90, CD71) 1 92 388
423420 AI571364 Hs 128382 Homo sapiens mRNA, cDNA DKFZp761l1224 (f 1 90 363
427923 AW274357 Hs 301406 hypothetical protein PP3501 1 90 304
406652 AW150304 Hs 277477 major histocompatibility ∞mplex, class 1 88 300
435624 AF218942 Hs 24889 formin 2 1 88 354
436552 NM.014038 HS 5216 HSPC028 protein 1 86 3 29
408204 AA454501 Hs 43666 protein tyrosine phosphatase type IVA, m 1 86 378
402728 C1002541* gι|4758590|reflNP_0O4249 1| im 1 86 314
420932 AW374605 Hs 11607 ESTs, Weakly similar to T21697 hypothed 1 84 472
458559 AW028820 Hs 283614 ESTs 1 78 306
400278 ENSP00000243264 Dolichyl-diphosphooligos 1 76 355
425751 T19239 Hs 1940 crystall , alpha B 1 76 531
420737 L08096 Hs 99899 CD70 , tumor nxrosis fxtor (ligand) s 1 74 300
410006 AW732308 Hs 57783 eukaryote translation initiation fxtor 1 74 379
454429 BE273437 Hs 301406 hypothetical protein PP3501 1 73 357
426321 BE046490 Hs 180677 zinc finger protein 162 1 72 327
402897 NM.023068* Homo sapiens sialoadhesin (SN 1 69 381
423639 AB037826 Hs 130411 KIAA1405 protein 1 67 331 448848 AF131851 Hs 22241 hypothetical protein 1 65 427
414420 AA043424 Hs 76095 immediate early response 3 1 60 302
440747 AW297226 Hs 137840 ESTs, Moderately similar to SIX4.HUMAN H 1 56 328
450635 AW403954 Hs 25237 mesenchymal stem cell protein DSCD75 1 55 373
400252 NM.0 465T Homo sapiens ubiquitin spxif 1 55 326
411825 AK000334 hypothetical protein FU20327 1 55 318
414328 Z21666 Hs 300463 aconitase 2, mitxhoπdπal 1 52 03
400263 Eos Control 1 51 342
421552 AF026692 Hs 105700 secreted fnzzled-related protein 4 1 50 319
436673 AF201931 Hs 5268 hypothedcal protein FLJ 10479 1 49 333
404739 Target Exon 1 49 3 10
438344 BE387726 Hs 343411 DEAD/H (Asp-Glu-Ala-Asp/His) box polypep 1 46 342
421696 AF035306 Hs 106890 Homo sapiens clone 23771 mRNA sequence 1 44 315
425240 AA306495 Hs 1869 phosphoglucomutase 1 1 44 304
412099 U64198 Hs 73165 interieukin 12 rxeptor, beta 2 1 43 371
434642 W25739 chromobox homolog 5 (Drosophila HP1 alph 1 42 307
404406 Target Exon 1 42 387
433320 D60647 Hs 250879 ESTs, Highly simila to CTXN RAT CORTEXI 1 41 380
447697 W52125 tubulin alpha 1 1 40 445
415780 U75898 Hs 78846 heat shxk 27kD protein 2 1 40 328
447216 R75812 Hs 169248 p75NTR-assxιated cell death exxutor, o 1 39 377
401772 NM.014520 Homo sapiens MYB binding prote 1 39 367
413031 BE515051 Hs 75160 phosphofructokinase, muscle 1 38 331
435604 AA625279 Hs 26892 unchaxtenzed bone marrow protein BM04 1 37 317
428011 BE387514 Hs 181418 KIAA0152 gene product 1 37 305
445580 AF167572 Hs 12912 skbl (S pombe) homolog 1 35 311
436703 AW880614 Hs 146381 RNA binding modf protein, X chromosome 1 34 305
438277 AL022326 Hs 6139 synaptogyπn 1 1 34 309
451481 AA300228 Hs 295866 hypothetical protein DKFZp434N1923 1 32 323
421818 AW992976 Hs 50098 NM.002489 Homo sapiens NADH dehydrogenas 1 31 301
412968 AW500508 Hs 75102 alanyl-tRNA synthetase 1 28 358
452378 AA025855 Hs 19597 KIAA1694 protein 1 25 308
447455 H38335 Hs 6750 Homo sapiens mRNA for FU0O058 protein, 1 24 345
402212 KIAA0430 gene product 1 21 303
428773 BE256238 Hs 193163 bπdgmg integrator 1 1 20 3 20
430067 U79458 Hs 231840 WW domain binding protein 2 1 18 303
418289 AW403103 Hs 83951 Hermansky-Pudlak syndrome 1 17 332
405752 Target Exon 1 00 340
422836 AL037365 Hs 194093 AKAP-bmding sperm protein roppoππ 1 00 300
TABLE 58B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Axessior i Genbank axession numbers
Pkey CAT Number Accession
400275 18707.1 NM.006513 BC009390 X91257 BC000716 BM450041 BI771139 AV
BI256788 BE386217 AU143368 AU133780 AU139704 BG531086 BE268235 BE545230 AU143414 AV761720 AU129842 AU143343 BE270064 BG473378 BE298813 BI772360 BE617354 AU140124 BE277005 BG746716 BE814960 AW161287 AV762084 BG898985 AW674875 AA313975 AV749916 AA374328 BM011248 AU098465 AW238888 BG940091 BG284599 AW410037 AA378483 D49914 AL573323 AL549819 AL572282 AL572871 AL568117 AL571945 AL547790 AL581217 AL514659 AL573926 AL540816 AW410038 BI262249 BG284713 AI659394 AI093582 AW965846 AA652206 AI686014 AA654357 AU146982 AW273447 AW157715 AW574750 BG683509 AW887824 AI818522 AA703770 BE542873 AA515504 AU154982 AA831254 AA828521 AI088602 AA854654 AA190869 BF062816 AA464944 BG261335 AI003584 BG402820 AA932098 W68695 AW18290O W37334 AI073864 C17924 C18528 AI299318 BF154399 BG319570 BF764242 BF764209 AI620320 T06029 BF447193 F29285 AL548949 BI333775 BE743602 BE618230 BE268139 BF036434 BE562718 BG774381 AA659833 AA297649 AA010945 BG105512 BE269205 T32623 BG015679 AL518518 AL517118 AL538396 AI049861 AL581976 AV752041 W26586 BE181609 AI963016 BG057603 AI720256 AA844560 AA055570 BE619606 C17428 AI042174 N93945 N69743 BF795208 AW057940 BI091399 AW975179 AA909936 H28712 W65445 AL515439 W37117 H66514 T85737 W37369
411763 1103041 1 AW862589 AW860959
424036 6226 1 NM.033445 BC0O1193 AI885781 BF794032AA476620 AA810906 AA810905 AI291244 AI885097 AI359708 AI335629 H97396 AI344589 AA300377
AA457566 AW771833 BE465621 AI364068 AI364452 AI648505 AI918342 AI928670 AA886580 AL531029 AA886344 AI186419 BG329096 BM045465 AL531028 BG437151 BE868021 AA179427
400237 9484.1 BC014122 M95627 NM 001087 BC020244 BC008809 AL542809 AL522027 AL517616 AL539615 AL555640 AL546094 AL528959 AL555071 BI858518
BI600907 AU120890 BE257146 AV707965 BI911155 BG575776 BE302876 BE277469 BE389232 AL533354 BE389814 BG829179 BE384687 BE276341 BG746912 BG42S149 AL047913 BE250277 BG116066 AW410799 BG478074 BG471558 BF813165 AA016192 BG334833 BE383857 AA218784 AL517615 BI822297 BE677910 AW169102 AW410800 AU144298 AI215124 AW275306 AU147438 BE205773 AI343920 AI972200 AA666173 Al 568496 AA742466 AI075003 BE858669 BI789274 BI964722 AI310312 AI928567 F285938I962793 AA053407 AA603722 AI419246 AA705597 BF445723 AA441804 AA774757 BG152609 AI301244 BF058147 AI879460 AI470194 D80510 AA923557 W69781 AI301243 AI880348 AL517973 AL542808 BE300552 AA143563 AL567123 AA553412 AA547999 AW262497 AW027349 AW469464 BE300553 AI687352 BG222276 AU146833 AA847176 AA724639 AI868270 AL530431 AI583619 AL563298 BI857771 C00178 AW130086 AI312650 AI470187 AL577668 BF816236 BF815492 BE221500 W48859 T54102 AI828100 AW190156 AI961278 AL565165 BF966475 BM013215 BG109077 BF793617 AA381776 AA381486 BF916382 BE745391 AA330239 BG117939 BF337403 BG770295 AL567952 AL571817 BE832508 BF032720
406642 0.0 AJ245210 AJ245212 AJ245211 AJ245213
441623 3362.1 BC022413 BE395396 BF754175 AA506621 BE706665 BE706678 AA723159 BE153169 BE706729 BE706558 BE153312 BE706706 AW371853
AW371849 BE153241 BC017410 AI337912 AI090244 AW090300 BE219837 AI623661 BE501576 BE501734 AI742232 AI023964 AI458424 AA975373 AI288904 AI984583 AA890325 N32562 AI358102 AW241694 AI038448 AI672071 AI018389 AA576391 AA977874 AW189392 W37448 AA612894 AI277548 H89551 AI699774 H89365 AA315805 AW579186 BC014584 BC014581 AW780125 AI672414 BE328145 AW600919 BF031306 AW172758 BE708322 AA345675 BE875779 H28241 H25318 BF540913 BG179688 BF110202 AA528775 W37573 BE041644 AW366504 BM129522 BM129822 AI122760 BE718200 AW887496 AA149420 BE706307 BE539395 BE748765 AI373653 R75904 BF979185 BF691393 BG495595 BI094458 BE706702 BG496559 BF248373 BG494800
433464 1015899.1 N92481 AW674508 AA593748 AW974058 AI475594
410295 2817.1 BG402852 BG545066 AA150252 AL036760 AA452480 AI033256 W68776 W93372 N31248 AI052219 AI367635 W69374 N88610 R58194 BI524854
BI497111 BF940043 AI129268 AI359798 AI056480 AA121421 AI042150 AW449003 AI418180 AI419420 AI356058 BF832243 AI349330 AI359448 W76647 BF477170 AA099163BF994549 AW608256 AA045418 H03770AL574791 AW069455 BE302148 AW022281 AW960273 AA121268 AI336371 AI989381 AI131425 AI147483 AI311S37 AW338638 AI141649 AA709414 AI187177 AA780884 AI333805 AA045312 AI623918 AI349421 W63753 W70299 AA557276 AA299007 N98212 W74064 N24823 T54892 AA054724 W73059 AI869152 N93462 N71889 AI537432 R71628 AA303089 AI498550 T60941 AV706417 AW067848 AI150677 AW338118 AI336313 AA826256 AI139518 AA662948 AA902723 AI970175 W68682 AI089380 AI148372 H99951 AW183001 AI270317 AA532767 AA044727 AA931652 R82469 AA150261 W67788 H67495 R80715 AW149812 N78914 AI862034 W61122 AW023118W69375T88917T47984 N21531 R35646AA055544 H15534AA688295AA090586AA044764 BF994641 79547 N21313 BF674610
H02874 AW975323 R16904 AA328030 AA054671 R79546 BF832310 AI249109 406678 0.0 U77534 U77537
406632 0 0 AB006838AB006837A8006836AB006834AB006835
400278 170.1 Y00281 NM.002950 BC010839 BC007995 BG675232 BM468552 AL555484 BG831516 BF035300 BG677277 BF852972 BE314901 BF850656 AI371816 AA292474 AA375747 AA308414 BM454544 BI333370 BM049921 81461428 BI465007 BI223401 BE856245 AW821164 BF914775 BF914761
AU125835 BI222678 BI091137 BF340536 BM462798 BI224452 BG707915 AL569160 AA443815 AW572867 AW363410 BF739268 BG010283 BI013120 BF818845 BF763468 AA305165 AI630370 AA039826 R24906 H02046 T96891 BF981330 AW936510 AA478169 H04587 BG166574 BI869342 BE562482 BE539637 AA165089 AL579118 AL553699 BE044054 AW117440 AI520674 BF435417 AW245648 AI952404 T29534 AU153459 AU152168 AW591591 AU146918 AI393187 AA478013 AU148143 AI224471 AI640728 AI871537 AW264752 N93787 AI189357 AV756134 AI471659 AU147466AA779206 AU149419AU149104 AU159135 AA312221 AW445119 AW021912 AI799771 F04407 AI285530 AI914643 AW068751 AA513325
AA164627 AA639285 AA569644 T96892 AI923594 BF439180 BI770936 BF032438 AU154884 AA682793 AW072992 AU158815 AI884444 AL048031 AU158922 AU152546 AI695187 AL048033 AI245650 AU148507 AW467451 BE536868 BF913001 BF062707 AL573082 AW067993 AA523354 BE886727 AI890705 AU159092 AI982693 AI817553 AA236729 AI687858 BG163767 AI524675 AI678155 AA127100 AI762661 AU159718 AI469720 AA483627 AW131696 R26868 AI199885 AW875614 AW938694 AW578974 BI763988 BG819168 BE874767 BG978292 BE162948 AL555483 AW189719 T56783 AI018819 AI476552 BI492837 AI824440 BG996262 AA932887 AI380726 R79530 AA622108 AI262575 T56782 R27437 BE784153
AW129549 AI675567 AI866759 BG987935 400252 2656.2 U44839 NM.004651 BC000350 BI458316 AU117940 BG759024 BG749694 BE799505 BG831537 AI816335 AA325352 AL547005 AW157038 AI859331
AI816186 AU150786 AL043549 AW162880 AU159233 AI143169 T03478 BE727648 AA764725 BE206603 AI369814 AI984369 AW157545 BE221486 H99016 AU159025 AI074496 AI494516 BE245950 AA704385 AA280862 AI479595 AI369776 BE671398 T05538 AA682249 BI677303 BE645335 AI359434 H92868 D52599 D53609054715 T06015 BE222174 AI954706053218 D53787 R69889 W86896 AI497670 R70771 BF309414 BE620147
BG910597 AW964968 BE836120 AL579715 H56512055956 BI044097 AL555239 BF220278 AA081991 AI819544 AW001573 AW131600 AI858764 D52367 W22034 BG818979 BG024561 BE702779 BI458863 BI910399 BG707755 BF348284 H1005581086315 BE620574 H41088 BG119517 W23267 W21941 AA328817 411825 7891.1 AK000695 AK000489 BC001688 BG235988 AW006329 AI887644 AI207230 AI148213 AI304333 AI634653AW662636AI281247 AA946921 AA424487 BE272330 AI830588 AA159183 AA977141 BG231801 AA631793 AA975194 BF817537 AA477798 BI906631 AW083424 AA625199 NM.017767
AK000334 BF984048 AW815634 AL573992 AA430612 AA928390 AA464447 AW340827 AA424290 AI927759 BG951502 AW881353 BI765535 400263 18977.1 Z11692 X51466 NM.001961 19997 BI224253 BG830478 AU122147 AU123437 BG113591 BG752624 BE886804 BI868669BG337216AW629935
BM016525 AI560409 AL562866 AI909178 BF849556 AA371735 BF038841 BF727115 BC006547 BG757526 AL555664 BI261304 BG770095 BI033486 BI517580 BG876486 BI011828 AI313235 BG831724 BF869862 BG998348 BI011834 BF888337 BF898627 BF092380 AW803215F01241 BF805719 BG876487 AW498536 BF988866 BG998849 AA248724 BG829202 BG756456 BG032392 BI859287 BM016990 BG332369 BE933685 BE166758
BM452445 AI937808 AW026128 N23684 AW006041 AI337621 F33111 BF344301 BG105450 BG387343 BF569547 BF154671 BM0O7368 BF569385 BE772007 BI199487 BF761700 BI261519 BF944452 BF898506 AI038390 BM044934 AW381142 BG743618 BE769206 BE89397381015047 BF886479 BF761350BE769769 BG766117 BF847365 BE397834 AW371121 BF089125 BE082996 BF183193 BG180964 BF089940 BI000274 BG255503 BG674499 BG774174 BI015084 434642 15461.1 AF147443 BM471094 AA948055AA973157 AA284289W25739 BI021926 BF898367 W02720 BF798341 BF378312AA427766 BG955568 BF899591
BF884215 447697 MH497.6 BE742621 AL528391 AA328484W52125AA321596AA022458AW971024AI052029 AI761638AA628498 BE619513AA412069AI027538AW514954 AI884599 AI097362 AI499259 AI419408 AW469200 AI992152 AI142045 AI066572 AI275439 AA581877 AI347308 AI016726 AI127541 AW002064 AI141786 AW051842 AI355329 AI198198 AI347858 AI027870 AI039163 AA576695 AI183286 AI362O01 AI361994 AA594668 AA459257 AA745778 AI139667 F20651 A1201510 AA832171 BM464599 BM464574 AI972621 AI183887 AW131911 AW771584 BE619828AA492218 AA025767 AA977354
AA385481 N45137 W73596 AI864400 AI200026 AI270953 F18139 W46301 H55825 AI039867 AI457570 AI928639 AI824685 AI083898 AW024570 AA285299 AW381097 AW582409 BE964181
TABLE 58C
Pkey Unique number conesponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column ae Genbank Idendfier (Gl) numbers 'Dunham, et al " refers to the publicadon endtled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402485495 Strand Indicates DNA strand from which exons were predicted"
Nt_posιtιon Indicates nucleotide posidons of predicted exons
Pkey Ref Strand NLposidon
401941 4982556 Plus 112022-112204
402007 7381786 Plus 143964-144081
401739 2982169 Plus 132194-132404
404405 7272262 Plus 83251-83415 401512 7622346 Plus 136399-136557 404439 7139680 Plus 5531555585
402273 2979528 Plus 28990-29203,32299-32402,32474-32668
405441 7408124 Plus 100952-101283
401454 9186923 Minus 114659-114832
401009 8117391 Minus 83179-83304
405268 4156151 Minus 24404-24521
405701 4263751 Plus 9324593364
401965 3126781 Minus 18239-18389,19921-20076
404835 6970743 Plus 85462-85684,88139-88287,9033591018,9482
401127 8699701 Minus 88327-88458,96150-96266
406161 7144954 Plus 1666516836
402728 9211639 Plus 3192-3569,4267-4728
402897 8570339 Plus 61939-62241,64304-64615,6514565391
404739 8217493 Plus 42742-43671
404406 7329316 Minus 4754547928 401772 9966243 Plus 183917-184042 402212 7689783 Minus 69382-69936 405752 9212305 Plus 91392-91528
TABLE 59A ABOUT 201 GENES UPREGULATED IN MELANOMA METASTASES FROM PATIENTS WITH PROGRESSIVE DISEASE RELATIVE TO MELANOMA METASTASES FROM PATIENTS WITH LIMITED DISEASE Table 59A lists about 201 genes upregulated in melanoma metastases from padents with progressive disease reladve to melanoma metastases from patients with limited disease
Genes were selxted from 59680 probesets on the Eos/Affymetnx Hu03 Genxhip array Gene expression data for exh probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflxdng the relative level of mRNA expression
Pkey Unique Eos probeset idendfier number
ExAxn Exemplar Axession number, Genbank accession number
UnigenelD Unigene number
Unigene Tide Unigene gene dtle
R1 90th percendle of Als for metastases from padents with progressive disease divided by Ihe 90th percendle of Als for metastases from padents with limited disease R2 90th percendle of Als for metastases from padents with progressive disease divided by the 90th percendle of Als for metastases from padents with limited disease, where the 15th percendle of normal dssue Als was subtrxted from both the numerator and denominator
Pkey ExAxn UnigenelD Unigene Title R1 R2
422168 AA586894 Hs 112408 S100 calcium-binding protein A7 (psoπas 858 1377
448966 AW372914 Hs 86149 phosphoinositol 3-phosphate-bιndιng prot 743 591
440099 AL080058 Hs 6909 DKFZP564G202 protein 707 4 56
431211 M86849 Hs 323733 gap juncdon protein, beta 2, 26kD (conn 691 351
420859 AW468397 Hs 100000 S100 calcium-binding protein A8 (calgran 690 644
418067 AI127958 Hs 83393 cystadn E/M 662 10 34
422166 W72424 Hs 112405 S100 calcium-binding protein A9 (calgran 647 1326
409632 W74001 Hs 55279 senne (or cysteine) proteinase inhibito 6 25 341
401780 NM.0O5557* Homo sapiens keradn 16 (fxa 6 10 424
437191 NM 006846 Hs 331555 senne protease inhibitor, Kazal type, 5 597 660
422511 AU076442 Hs 117938 collagen, type XVII, alpha 1 589 357
412636 NM 004415 desmoplakin (DPI, DPII) 582 351
417124 BE122762 Hs 25338 ESTs 5 16 3 16
430686 NM 001942 Hs 2633 desmogle 1 503 357
421733 AL119671 Hs 1420 fibroblast growth fxtor receptor 3 (xh 484 4 15
422192 AA305159 Hs 113019 fls485 4 79 459
407366 AF026942 Hs 17518 gb Homo sapiens cιg33 mRNA partial sequ 433 237
429493 AL134708 Hs 145998 ESTs 4 28 479
456525 AW468397 Hs 100000 S100calcιum-bιndιπg protein A8 (calgran 4 23 482
409010 AI648675 Homo sapiens, Similar to RIKEN cDNA 1700 423 369
410748 BE383816 Hs 12532 chromosome 1 open reading frame 21 4 11 233
409760 AA302840 gb EST10534 Adipose dssue, white I Homo 406 365
424670 W61215 Hs 116651 epithelial V-like andgen 1 402 407
417366 BE185289 Hs 1076 small prolme-πch protein 1B (comifϊn) 397 471
418663 AK001100 Hs 41690 desmocollin 3 395 508
402075 ENSP00000251056* Plasma membrane calcium 393 585
428330 L22524 Hs 2256 matrix metalloproteinase 7 (matπlysm. 390 319
427809 M26380 Hs 180878 lipoprotein lipase 387 3 21
413859 AW992356 Hs 8364 Homo sapiens pyruvate dehydrogenase kma 385 575
431048 R50253 Hs 249129 cell death-inducing DFFA-like effxtor a 380 3 10
431369 BE184455 Hs 251754 sxretory leukxyte protease inhibitor ( 3 79 3 36
421485 AA243499 Hs 104800 hypothedcal protein FU10134 367 335
429852 AB010445 Hs 225948 small inducible cytokine subfamily A (Cy 365 4 14
418686 Z36830 Hs 87268 annexin A8 365 3 62
448429 D17408 Hs 21223 calponm 1, basic, smooth muscle 364 3 18
422963 M79141 Hs 13234 ESTs 360 4 10
428874 W32133 Hs 194366 transthyredn (prealbumin, amyloidosis t 358 397
401785 NM.002275* Homo sapiens keradn 15 (KRT1 358 505
454117 BE410100 Hs 40368 adaptor-related protein complex 1, sigma 356 1 92
419329 AY007220 Hs 288998 S100-type calcium binding protein A14 354 562
424012 AW368377 Hs 137569 tumor protein 63 kDa with strong homolog 353 470
417515 L24203 Hs 82237 ataxia-telangixtasia group D-assxiated 352 8 33
430376 AW292053 Hs 12532 chromosome 1 open reading frame 21 351 232
454229 AW957744 Hs 278469 lacπmal proline nch protein 350 312
401781 Taget Exon 345 3 57
408000 Ll 1690 Hs 198689 bullous pemphigoid andgen 1 (230/240kD) 345 507
431567 N51357 Hs 260855 Homo sapiens cDNA FU21410 fis, done C 344 503
419648 T73661 Hs 91877 thyroid hormone responsive SPOT14 (rat) 342 7 72
414798 AI286323 Hs 97411 hypothetical protein MGC12335 341 265
442315 AA173992 Hs 7956 ESTs, Moderately similar to ZN91.HUMAN Z 341 503
442498 U54617 Hs 8364 Homo sapiens pyruvate dehydrogenase kma 3 32 286
410883 D43767 Hs 66742 CCL17 chemokine (TARC) (SCYA17) 328 3 18
418026 BE379727 Hs 83213 fatty xid binding protein 4, adip∞yte 326 3 10
453309 AI791809 Hs 32949 defensin, beta 1 324 364
420783 AI659838 Hs 99923 Ixtm, galxtoside-binding, soluble, 7 321 364
409601 AF237621 Hs 80828 keradn 1 (epidermolydc hyperiteratosis) 3 19 437
413163 Y00815 Hs 75216 protein tyrosine phosphatase, rxeptor t 316 548
452101 T60298 Hs 10844 Homo sapiens cDNA FU14476 fis, clone MA 3 15 360
412633 AF001691 Hs 74304 peπplakin 315 398
407839 AA045144 Hs 161566 ESTs 315 4 11
427318 AF186081 Hs 175783 zinc transporter 3 11 358
427899 AA829286 Hs 332053 serum amyloid A1 310 3 53
421948 L42583 Hs 334309 keradn 6A 308 275
452744 AI267652 Hs 246107 Homo sapiens mRNA, cDNA DKFZp434E082 (fr 305 299
410001 AB041036 Hs 57771 kallikrein 11 304 302
413435 X51405 Hs 75360 carboxypepddase E 300 240
428500 AI815395 Hs 184641 fatty xid desaturase 2 298 522
410099 AA081630 KIAA0O36 gene product 297 205
437679 NM 014214 Hs 5753 ιnosιtol(myo)-1(or 4)-monophosphatase 2 293 345
413835 AI272727 Hs 249163 fatty xid hydroxylase 293 478 446068 AL049801 Hs 13649 Novel human gene mapping to chomosome 13 289 293
450680 AF131784 Hs 25318 Homo sapiens clone 25194 mRNA sequence 288 314
428398 AI249368 Hs 98558 ESTs 288 205
417433 BE270266 Hs 82128 5T4 oncofetal trophoblast glycoprotein 286 212
427919 AA173942 Hs 326416 Homo sapiens mRNA, cDNA DKFZp564H1916 (f 284 298
412676 NM 000165 Hs 74471 gap junction protein, alpha 1, 3kD (ran 283 282
428695 AI355647 Hs 189999 punnergic rxeptor (family A group 5) 283 237
446989 AK001898 Hs 16740 hypothedcal protein FU11036 282 273
428471 X57348 Hs 184510 stradfin 279 331
416305 AU076628 Hs 79187 ∞xsxkie virus and adenovirus receptor 279 372
433147 AF091434 Hs 43080 platelet denved growth fxtor C 277 1 70
412326 R07566 Hs 73817 small inducible cytokine A3 (homologous 276 218
425787 AA363867 Hs 155029 ESTs 275 242
450172 NM 005864 Hs 24587 signal transducdon protein (SH3 contan 275 236
421773 W69233 Hs 112457 ESTs 273 559
408536 AW381532 Hs 135188 ESTs 273 517
437143 AW204056 Hs 8917 ESTs 272 1 84
452862 AW378065 Hs 8687 ADAMTS2 (a dismtegπn-like and metallo 270 1 82
418394 AF132818 Hs 84728 Kmppel-like factor 5 (intesdnal) 269 462
410325 A8023154 Hs 62264 KIAA0937 protein 269 232
447164 AF026941 Hs 17518 vip n, similar to inflammatory respon 269 374
444984 H15474 Hs 132898 fatty xid desaturase 1 267 236
434727 H43374 Hs 7890 Homo sapiens mRNA for KIAA1671 protein. 265 1 78
420876 AA918425 Hs 177744 ESTs 264 726
426106 AI678765 Hs 21812 ESTs 264 251
419517 AF052107 Hs 90797 Homo sapiens done 23620 mRNA sequence 264 266
409509 AL036923 Hs 322710 ESTs 262 209
426354 NM 004010 Hs 169470 dystrophin (muxular dystrophy, Duchenne 262 268
432503 AA551196 Hs 188952 ESTs 262 464
409341 AI963376 Hs 12532 chromosome 1 open reading frame 21 262 1 74
421116 T19132 Hs 101850 retinol-bindiπg protein 1 , cellular 262 290
456247 R09746 gb yf27d10 r1 Soaes fetal liver spleen 261 343
414217 AI309298 Hs 279898 Homo sapiens cDNA FU23165 fis clone L 260 384
439706 AW872527 Hs 59761 ESTs, Weakly similar to DAP1. HUMAN DEATH 258 349
440659 AF134160 Hs 7327 claudin 1 257 397
459710 AI701596 Hs 121592 ESTs 257 359
430937 X53463 Hs 2704 glutathione peroxidase 2 (gastromtestin 256 335
433882 U90441 Hs 3622 prxollagen-prolme, 2-oxoglutarate 4-dι 251 375
427666 AI791495 Hs 180142 calmodulin-like skin protein (CLSP) 251 302
431103 M57399 Hs 44 pleiotrophm (hepann binding growth fx 247 353
449550 AA353125 Hs 184721 ESTs 243 422
424675 NM 005512 Hs 151641 glycoprotein A repetitions predominant 240 622
442000 H38671 Hs 8071 KIAA0735 gene product syπapdc vesicle 238 3 14
427122 AW057736 Hs 323910 HER2 rxeptor tyrosine kinase (c-erb-b2, 236 359
420039 NM 004605 Hs 94581 sulfotransferase family, cytosolic, 2B 236 291
412477 AA150864 microsomal glutathione S transferase 1 234 415
450693 AW450461 Hs 203965 ESTs 232 393
406433 Target Exon 229 320
423017 AW178761 Hs 227948 senne (or cysteine) proteinase inhibito 2 24 440
422158 L10343 Hs 112341 protease inhibitor 3, skm-deπved (SKAL 223 4 87
421314 BE440002 Hs 180324 Homo sapiens, clone IMAGE 4183312, mRNA, 2 23 4 22
422083 NM 001141 Hs 111256 axhidonate 15lιpoxygenase, sxond typ 222 5 71
442503 AF147078 Hs 150853 p53-responsιve gene 5 221 486
418007 M13509 Hs 83169 matrix metalloproteinase 1 (interstitial 219 390
442572 AI001922 Hs 135121 hypothetical protein FLJ22415 216 287
413278 BE563085 Hs 833 interferon-sdmulated protein, 15 kDa 2 13 327
414521 D28124 Hs 76307 neuroblastoma, suppression of tumongeni 209 528
428899 AA744610 Hs 194431 palladia 208 376
417079 U65590 HS 81134 interieukin 1 rxeptor antagonist 206 309
439496 BE616501 Hs 32343 Homo sapiens Simila to RIKEN cDNA 1110 205 288
450423 AA486735 Hs 31869 sialoadhes 202 304
444105 AW189097 ESTs 201 305
430410 AF099144 Hs 347933 tryptase beta 1 201 371
409453 AI885516 Hs 95612 ESTs 201 434
429655 U48959 Hs 211582 myosin, light polypepdde kinase 200 528
432374 W68815 Hs 301885 Homo sapiens cDNA FU 11346 fis, clone PL 1 99 359
447990 BE048821 Hs 20144 small inducible cytokine subfamily A (Cy 1 92 4 16
451541 BE279383 Hs 26557 plakophilin 3 1 89 390
425206 NM.002153 Hs 155109 hydroxysteroid (17-beta) dehydrogenase 2 1 89 329
410197 NM.0O5518 Hs 59889 5hydroxy-3-methylglutaryl-Coenzyme A sy 1 84 304
401760 Target Exon 1 84 332
427579 AA366143 Hs 179669 hypothedcal protein FLJ20637 1 83 469
424263 M77640 Hs 1757 L1 cell adhesion molxule (hydrocephalus 1 83 296
452208 AA024792 Hs 31895 hypothetical protein MGC4093 1 82 370
420074 AA253425 Hs 190074 ESTs 1 81 290
429299 AI620463 Hs 347408 hypothetical protein MGC13102 1 79 365
427540 R12014 Hs 20976 ESTs 1 77 292
429259 AA420450 Hs 292911 Plakophilin 1 76 365
422106 D84239 Hs 111732 Fc fragment of IgG binding protem 1 75 406
453556 AA42541 Hs 33287 nuclea fxtor 1/8 1 74 307
436895 AF037335 Hs 5338 carbonic anhydrase XII 1 73 322
406851 AA609784 major histocompatibility complex, class 1 73 396
444726 NM.006147 interferon regulatory fxtor 6 1 71 365 444781 NM 014400 Hs 11950 GPI-anchored metastasis-assxiated prote 1 71 4 13
446051 BE048061 Hs 37054 ephπn-A3 1 68 361
408522 AI541214 Hs 46320 Small prolme-πch protein SPRK (human, 1 67 300
450835 BE262773 Hs 25584 hypothetical protein FLJ10767 1 66 3 11
432004 BE018302 Hs 2894 plxental growth fxtor, vascular endoth 1 66 3 23
431179 AI338644 Hs 195432 aldehyde dehydrogenase 2 family (mitxho 1 64 329
415213 NM.002933 Hs 78224 πbonuclease, RNase A family, 1 (pancrea 1 57 394
423184 NM 004428 Hs 1624 ephπn-A1 1 56 288
414694 NM 015362 Hs 76907 HSPC002 protein 1 56 292
458746 AI380797 Hs 158992 ESTs 1 56 292
433091 Y12642 Hs 3185 lymphxyte andgen 6 complex, Ixus D 1 55 3 75
438367 N79688 Hs 204354 ras homolog gene family, member B 1 54 456
403903 C5001632* gι|10645308|gb|AAG21430 1|AC00 1 53 399
445656 W22050 Hs 21299 ESTs, Weakly similar to AF151840 1 CGI-8 1 52 316
443604 C03577 Hs 9615 myosin regulatory light chain 2, smooth 1 50 4 25
429211 AF052693 Hs 198249 gap junction protein, beta 5 (connex 3 1 50 335
415274 AF001548 Hs 78344 myosin, heavy polypepdde 11, smooth mus 1 9 321
418226 AA424202 Hs 83834 cytxhrome b-5 1 49 390
454194 BE141599 gb QV2-HT0083-071299-015h01 HT0083 Homo 1 48 298
434879 M34572 Hs 159263 ∞llagen, type VI, alpha 2 1 46 326
418400 BE243026 Hs 301989 KIAA0246 protein 1 46 400
409178 BE393948 HS 50915 kallikrein 5 145 294
433662 W07162 Hs 150826 RAB25 RAB25. member RAS oncogene family 1 44 318
429002 AW248439 Hs 2340 juncbon plakoglobin 1 43 307
422087 X58968 Hs 111301 matπx metalloproteinase 2 (geladnase A 1 40 461
452934 AA581322 Hs 4213 hypothedcal protein MGC16207 1 38 311
417483 BE549343 Hs 82208 xyl-Coenzyme A dehydrogenase, very long 1 37 432
427929 BE613835 Hs 181159 Homo sapiens mRNA, cDNA DKFZp434F0217 (f 1 37 299
425184 BE278288 Hs 155048 Lutheran blood group (Auberger b andgen 1 36 317
407143 C14076 Hs 332329 EST 1 36 299
416950 AL049798 Hs 80552 dermatopondn 1 35 339
406799 AA908548 gb og83g12 s1 NCI.CGAP.Ov8 Homo sapiens 1 34 317
442599 AF078037 Hs 324051 RetA-assxiated inhibitor 1 33 330
413659 BE155647 gb PM2-HT0355130100-002-e09*HT0353 Homo 1 32 289
454478 AW805749 superoxide dismutase 2, mitxhondπal 1 30 350
404467 Target Exon 1 29 357
452516 AA058630 Hs 29759 RNA POLYMERASE I AND TRANSCRIPT RELEASE 1 28 300
412524 AA417813 Hs 44208 hypothedcal protein FU23153 1 27 305
422354 U20982 Hs 1516 insulin-like growth factor-binding prote 1 24 286
406711 N25514 Hs 77385 myosin, light polypepdde 6, alkali, smo 1 24 329
450796 NM 001988 Hs 25482 envoplakin 1 23 321
431526 Y10129 Hs 258742 myosin-bindmg protein C, cardix 1 23 365
452791 AA227581 Hs 30634 hypothetical protein FU20509 1 22 290
406742 AI468091 Hs 279860 tumor protein, transladonally-controlle 1 19 347
406712 M31212 Hs 77385 myosin, light polypepdde 6, alkali, smo 1 18 2 91
443672 AA323362 Hs 9667 butyrobetame (gamma), 2-oxoglutarate di 1 10 350
413048 M93221 Hs 75182 mannose rxeptor, C type 1 1 00 299
453165 S74727 Hs 32042 aspartoxylase (ammoacylase 2, Canavan 1 00 291
TABLE 59B
Pkey Uniq ue Eos probeset idendfier number
CAT number Gene cluster number
Accessior i Genbank axession numbers
Pkey CAT Number Accession
412636 1438.1 M77830 NM.004415 AF139065 BG681115 BG740377 BI712964 BG000656 AA128470 BI438324 H27-
J05211 BG698865 BG740734 BG680618 BG739778 BI765807 BM353403 BM353248 AW177784 AW205789 AW951576 AW848592 BE182164 BF149266 BE940187 BI060445 BI060444 BF350983 BE720095 BE720069 BE715154 BE0825848E082576 BE004047 AA8573168I039774 BE713818 BE713548 AW170253 BE160433 BI039775 AW886475 BM462504 BE931734 BF149264 AA340777 BF381183 BG621737 AU127260 AW364859 8F993352 BG223489 BE819009 BF381184 BE715956 R58704 AA852212 AW366566 BI090358 BF087707 BE819046 BE819O05 AA377127 BE073467 BE819069 BE819048 BI036306 BG990973 BI040954 BF919911 AU140155 AI951766 AI434518 AW804674 BF752969 BE837009 BE925826 BF149265 AW995615 BE814264 BI039782 AU140407 BE144243 BE709863 BF985642 BE001923 BF933510 AW265328 BG436319 BE182166 AW365175 AW847688 BE818280 AW177933 BF873679 AW178000 BE082526 BF476866 BF086994 BF592276 BE082507 BE082514 BE082505 BF873693 AW068840 AW847678 BF804153 AW365157 BE813930 BE002030 AW365153 BE184941 BF749421 BE184920 BF839562 BE184933 BF842254 BE698470 BE931048 BF999889 BF368816 BE184924 BE159646 BE714632 BE184948 BG986845 AA131128 AA099891 W39488 C04715 BF096124 BE865341 AW799304 AL603116 BE149760 BE705967 BE705966 BE705968 AW848723 AW376699 AW376817 AW376697 BG005097 BF751115 BE696084 AW848371 AW376782AW848789AW849074AW361413 BF927725 BF094211 AW997139 BE865474 BE185187 BE156621 BE715089 BE713297 BE713298 BE179915 AW799309 BF872345 BF088676 BE705939 AW752599 BG005197 BF350086 BE715196 BE715155 BF752396 BF093817 BF831190 BF752409 BE006561 BG959922 BF094833 BF094748 BF094583 AW377699 AW607238 BE082519 AW377700 BF349467 AI190590 Al 554403 AI392926 AU158477 BI467252 AU159919 AI760816 BF082516 AI439101 AA451923 AI340326 AI590975 BI791553 AI70O963 AI142882 AA039975 AA946936 AA644381 BM314884 AA702424 AI417612 AW190555 AI220573 AI304772 AI270345 AI627383 AA552300 AI911702 AW166807 AI346078 W95070 AA149191 AA026864 Al 830049 AW780435 AI078449 AI819984 AI858282 BI468588 AI860584 AI025932 AA026047 AA703232 AA658154 AA515500 AW192085 AA918281 T77861 AI927207 AI205263 BF082491 AW021347 AI568096 BE939862 AA088866 D12062 AA056527 AA782109 W19287 W02156 AW150038 AA022701 T87181 H44405 AI910434 BF082513 AI494069 AI270027 AI635878 AA128330 BG681425 BE706078 R20904 BG680059 BG676647 BF764409 AA026654 AV745530 BI762796 BG287391 AW798780 BE706045 BE926470 AW799118 BF087996 BE002273 AW879451 AI571075 BE067786 AV721320 AI022862 N29754 C03378 N84767 AA131077 H30146 BE714290 AI686869 AI568892 AI915596 AW105614 AI887258 AI538577 BE926474 BE067737 BG319486 AA247685 AW798883 AW103521 BF989173 AW860878 BE939707 BE185750 BE714064 BE713903 BE713868 BE713763 BG950164 BE713810 AW365151 BG955489 BE005272 BF915937 AW365148 AI905927 BF992780 AW853812 BG954443 BI770853 BG679406 BG7408328G681087 BG698430 AA455100 T87267 BE696209 BE696210 BI089483 BE006273 BE872225 AW391912 BE925515 BG677012 BG741970 AA026480 BE705999 BG677157 BE009090 BG681378 BE712291 BG961498 BG678984 BI040941 AA337270 AW384371 AW847442 BI058659 BE813665 W95048 W25458 AW177786 AA025851 BE931733 BF154837 BG949393 BE714441 AW996245 BE711801 AI284090 BE064323 BE719390 BE940148 BG991212 BF375714 BF349522 BG996267 T48793 BI013292 BE001925 AW365156 AW365154 AW606653 BF763109 BE931637 BE167181 BE713879 BF354008 BF678726 H90899 AW365145 W38382 AI498487 409010 10331.1 AL575207AL551714 BM014781 BG542863 BG771232 AA429722 AI377511 AI770155 AA716665 BG003427 AA810811 AA442760 AA128610
AA059411 AI796263 AI494075 AI572127 AA420992 BF436083 AI648675 AA878813 BI488614 BG700886 AA128609 AV702879 AA731146 AI580336
AI373224 AA919169 AI758175 AA976350 BG701414 BF057794 AW135598 AA062583 BI549631 AI185077 AA933879 AW024454 AA193289 AA045194
BG928396 BE856883 BF435859 AA196423 AW237471 R99289 D61992 BE856637 BF368270 AA194235 N51319 AA383499 N63065 BG548812
BF027898 BG779448
409760 865166 1 AA302840 T93016 T92950 AU184997 AA077551 410099 16732 ϊ AK055674 AW965247 AV751598 AA290926 R53043 AA331387 AK056148 BI917678 BG819395 BG911971 BG820167 AI174254 AA348720 AA364503
BG714279 AW893230 AA081774 H24222 AV727176 BF875715 AA081630 BE000834 AA334880 AL563737 BG029709 W52882 AI439658 BE551237
AA283724 BF109530 AI457096 AI805992 BE467736 AA693467 AI697593 AI887863 AI167419 AW901980 AW901768 BE702179 AA484549 T23811
BE327043 AA716027 AA917004 AA167714 BF339675 AA084618 AI418634 T31586 AA436630 AI366472 AA706191 AI422304 AI204899 AI041169
AA211402 AW827081 AA788593 T32736 AI767935 AA747914 T03534 AW959843 AL119527 BE327037 AW901982 AW993370 AW901977 AW902071
W60090 N79906 D52685 T07735 BE702069 BE702172 T08671 BE767121 8E767117 BE767113
456247 2142387.1 R10170R09746 412477 8669.2 AI220117 AI857837 AI218371 BM091400 AI304964 AI198508 AI400738 AW571549 AW950042 AI089943 AA437280 AU150878 BF197070 AI267984
BF594181 BF196688 AI433152 AI338921 A1620364 AI280197 AA652531 AI674938 AI342447 AI620350 AI281295 AI148621 N54787AI338121
AI281153 N51899 AI087072 AA954788 AW069054 AI346309 BG529629 AI340135 BF083036 AI167365 AW819657 AA935468 AI467868 AW148701
AI383720 BE047685 AW015498 AA937149 AA708346 AW771478 AW802508 H53334 AW389204 AW798230 AI553922 AI560688 AW950043 AI961682
AV706506 R01853 AA126514 N62757 AI536893 AI926052 AI418720 N99964 AI568933 AI915737 AI080691 AI185358 N48996 N68575 H82824 H60037
AI247247 T95664 BF593863 AI749637 AW088541 AA991294 AA887452 AI073726 AA633132 AA629674 AA629649 AA629656 AA578595 AI168758
AA804572 AI085786 AA994396 AA991209 AA948663 AA929054 AA927952 T87001 AA928210 AA629296 AW802267 AW384129 BF744400 AA194110
AI382839 AA194837 AA406284 AI250750 R37035 AI525586 W01244
444105 649788 1 AW189097 AI123917 AI123926 406851 0.0 AA609784 R97304 444726 3503 2 BG285809 BE940673 BG432524 BE157554 BG676980 AU144284 AI745383 AU159045 AI693500 AW293668 AW371408 BE856107 AI338042
AW188320AI698246BE673290AW297653AA156532AI017342AI916754AI190644AI184302AA857671 BE857018AI307420 AI318157 AW204327
AW664668 AW274339 AA582788 AI345741 AW301433 AI873468 AW137388 BF718731 BF718413 AA877495 BF001575 AI824693 AW849604
AW849405 AW849396 AW849173 BE673179 AI611327 AA705753 BE715478 AW849414 AW849399 AI085759 AI140849 T67412 AI889885 AW104647
AI912495AI889874 AI744241 BE717113 BE717108 BE715564 AI872527 AA029457 C00338 AI469558 BE715577 AA04S413 BF843813
454194 171445.1 BE141599 AW845895 AW178095 BE140914 BE140909 AW178107 AW178094 AW845883 BF349267 AW845898 AW845811 AW845814 BF767720 406799 0.0 AA908548 413659 1526081.1 BE155647 BE155627 454478 4273 16 AW796921 AW798102 AW805749 AW805872 BF985060 AW794380 BF380449 AW794466 AW794538
TABLE 59C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publicadon endtled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposidon Indicates nucleotide positions of predicted exons
Pkey Ref Strand NLposidon
401780 7249190 Minus 28397-28617,28920-29045,2913529296,2941
402075 8117407 Plus 121907-122035,122804-122921,124019-12416
401785 7249190 Minus 165775165996,166189-166314,16640516656
401781 7249190 Minus 8321583435,83531-83656,8374583901,8423
406433 9256507 Plus 58094-58565
401760 9929699 Plus 8312683250,85320-85540,94719-95287
403903 7710671 Minus 101165102597
404467 8077630 Minus 24951-25853
TABLE 60A ABOUT 53 GENES UPREGUIATED IN BENIGN NEVI RELATIVE TO NORMAL TISSUES
Table 60A lists about 53 genes upregulated in benign nevi relative to normal tissues These genes were selxted from 59680 probesets on the Eos/Affymetnx Hu03 Genxhip array
Gene expression data for exh probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflxdng the reladve level of mRNA expression Pkey Unique Eos probeset idendfier number
ExAxn Exemplar Axession number, Genbank accession number
UnigenelD Unigene number
Unigene Tide Unigene gene dtle
Rl. average of benign nevi Als divided by the 90th percentile of normal dssue Als R2 average of benign nevi Als divided by 90th percentile of normal dssue Als, where the 15th percentile of normal dssue Als was subtrxted from both the numerator and denominator
Pkey ExAccn UnigenelD Unigene Title R1 R2
430377 NM 001922 Hs 301865 dopxhrome tautomerase (dopxhrome delta 869 562
409601 AF237621 Hs 80828 keratin 1 (epidermolydc hyperkeratosis) 837 1347
430686 NM 001942 Hs 2633 desmoglein 1 726 478
406964 M2Ϊ305 FGENES predicted novel sxreted protein 650 373
426555 NM.000372 Hs 2053 tyrosinase (xulxutaneous albinism IA) 640 735
429852 AB010445 Hs 225948 small inducible cytokine subfamily A (Cy 623 885
430822 AJ005371 Hs 248017 glyceraldehyde-3-phosphate dehydrogenase 549 432
420208 BE276055 Hs 95972 silver (mouse homolog) like 545 984
431360 NM 000427 Hs 251680 loπcπn 388 300
421773 W69233 Hs 112457 ESTs 380 904
438380 T06430 Hs 6194 chondroidn sulfate proteoglycan BEHAB/b 374 423
431089 BE041395 ESTs, Weakly similar to unknown protein 321 234
420798 W93774 Hs 99936 keradn 10 (epidermolydc hyperi ratosis 308 320
442503 AF147078 Hs 150853 p55responsιve gene 5 288 501
405451 dihydropyπmidinase-like 3 288 285
452240 AI591147 Hs 61232 ESTs 286 1 90
402525 NM.002699* Homo sapiens POU domain, das 278 272
413171 AA318325 Hs 75219 tyrosinase-related protein 1 265 558
439496 BE616501 Hs 32343 Homo sapiens, Similar to RIKEN cDNA 1110 255 3 18
422656 AI870435 Hs 1569 LIM homxbox protein 2 245 238 453317 NM 002277 Hs 41696 keratin, har, xιdιc,1 234 376 420783 AI659838 Hs 99923 Ixdn, galxtoside-bindmg soluble, 7 233 243 422511 AU076442 Hs 117938 collagen, type XVII, alpha 1 228 200 427666 AI791495 Hs 180142 calmodulm-like skin protein (CLSP) 228 250 459702 AI204995 gb an03c03 xl Stratagene schizo bran SI 225 1 85 451668 Z43948 Hs 326444 cartilage xidic protein 1 223 242 431703 AA514264 Hs 4437 tnosephosphate isomerase 1 215 220 453511 AL031224 Hs 33102 AP-2 beta transcnpdon fxtor 2 13 220 401780 NM.005557* Homo sapiens keradn 16 (fxa 213 202 416640 BE262478 Hs 79404 neuron-spxific protein 211 202 444105 AW189097 ESTs 211 1 46 428748 AW593206 Hs98785 Ksp37 protein 209 1 52 418067 AI127958 Hs 83393 cystadn E/M 209 232 417017 AA976064 Hs 180842 nbosomal protein L13 208 252 401781 Target Exon 202 203 407178 AA195651 AP-2 beta tranxπpdon fxtor 1 88 2 17 452308 AI167560 Hs 61297 ESTs 1 84 238 429348 AJ242859 Hs 199731 Langerhans cell spxific c-type Ixdn 1 83 326 402880 Target Exon 1 69 2 10 434276 AF123659 Hs 93605 leucine zipper, putadve tumor suppresso 1 69 220 401963 NM.006311 Homo sapiens nuclear receptor 1 66 202 424010 AL080188 Hs 137556 Homo sapiens mRNA, cDNA DKFZp434A132 (fr 1 65 205 432800 BE391046 Hs 278962 AIM-1 protein 1 61 283 400328 X87344 transporter 2, ATP-binding cassette, sub 1 57 227 412580 AA113262 Hs 17901 Homo sapiens, clone IMAGE 3937015, mRNA, 1 55 242 435292 N20514 Hs 172965 ESTs 1 53 221 408561 AI308037 Hs 84120 hypothedcal protein MGC13016 1 52 201 427923 AW274357 Hs 301406 hypothedcal protein PP3501 1 47 271 447763 BE619911 Hs 115803 hypothedcal protein 1 40 2 10 454478 AW805749 superoxide dismutase 2, mitochondrial 1 30 236 427289 AI097346 phosphosenne aminotransferase 1 24 202 430513 AJ012008 Hs 241586 G6C protein 1 20 2 18 411388 X72925 Hs 69752 desmocollm 1 1 00 243
TABLE 60B
Pkey Unique Ex probeset idendfier number
CAT number Gene cluster number
Axession Genbank xcession numbers
Pkey CAT Number Accession
431089 125941 2 BG940189AW063489AA715980 BF001091 BF880066AA666102AA621946 AA491826
459702 539529.1 BG207209 BE166299 AI204995 BG199355 AW969908 AA528756 AW440776 BI044354
444105 649788.1 AW189097 AI123917 AI123926
407178 683007.1 AW235123AA195651
454478 4273 16 AW796921 AW798102 AW805749 AW805872 BF985060AW794380BF380449AW794466 AW794538
427289 1820.2 BC007350 BG766159 BG769338 BG761999 BG744385 BG770572 AW370610 AW370581 AA978353 AW327973 AW402425 AI889380 AA868504
AW612968 AA630644 AI751211 N26980 AI394506 AA747849 BF154926 BF477185 AA649647 R39135 AI750216 T35363 W36278 AW079375 AW612240 AA505495 AA515380 BG760793 AW370651 BG766029 AW370595 BF229885 BG762422 BG764907 T50662 AA025671 AW815715 AV703420 H65047 AA485582 R56186 H90385 R55913 BI261497 BI018403 BF376945 T75578 BF933325 BF932853 BG502266 AW868934 AV683504 BI018121 N41953 BF933343 BF932871 H08334 R14012 BF897622 T50816 BG698803 BF340083 Z20199
TABLE 60C
Pkey Unique number conesponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Identifier (Gl) numbers "Dunham, et al " refers to the publicadon endtled "The DNA sequence of human chromosome 22* Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted
NLposition Indicates nudeodde positions of predicted exons
Pkey Ref Strand NLposidon 405451 7622517 Minus 145945146227
402525 9800048 Minus 1974520683
401780 7249190 Minus 28397-2861728920-29045,29135292962941
401781 7249190 Minus 8321583435,83531-83656,8374583901,8423 402880 9926561 Minus 4155541865 401963 3126783 Plus 51382-51521
TABLE 61A ABOUT 72 GENES UPREGULATED IN BENIGN NEVI RELATIVE TO PRIMARY MELANOMAS
Table 61 A lists about 72 genes upregulated in benign nevi reladve to pπmary melanomas Genes were selxted from 59680 probesets on the Eos/Affymetnx Hu03 Genxhip anay Gene expression data for exh probeset obtaned from this analysis was expressed as average intensity (Al), a nomialized value reflxdng the reladve level of mRNA expression
Pkey Unique Eos probeset idendfier number
ExAxn Exemplar Axession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene dtle R1 average of benign nevi Als divided by the 90th percendle of pnmary melanoma Als
R2 average of benign nevi Als divided by the 90th percendle of primary melanoma Als, where the 15th percendle of normal dssue Als was subfrxted from both the numerator and denominator
Pkey ExAxn UnigenelD Unigene Tide R1 R2 431103 M57399 Hs44 pleiotrophin (hepann binding growth fx 380 250
424897 D63216 Hs 153684 frizzled-related protein 340 269
429852 AB010445 Hs 225948 small inducible cytokine subfamily A (Cy 290 325
431089 BE041395 ESTs, Weakly similar to unknown protem 282 1 56 456034 AW450979 gb UI-H-BI3-ala-a-12-0-UI s1 NCI_CGAP.Su 273 300
417017 AA976064 Hs 180842 πbosomal protein L13 271 373
402880 Target Exon 256 355
422656 AI870435 Hs 1569 LIM homxbox protein 2 245 338
426451 AI908165 Hs 169946 GATA-bindmg protein 3 (T-cell rxeptor 241 1 91
423467 AK000214 Hs 129014 hypothedcal protein FLJ20207 2 32 224
424797 AA622394 Hs 153177 πbosomal protein S28 229 253
459702 AI204995 gb an03c03 x1 Stratagene schizo bran SI 225 2 19
406964 M21305 FGENES predicted novel sxreted protein 2 24 1 65
428748 AW593206 Hs 98785 Ksp37 protein 209 1 43
402525 NM.002699* Homo sapiens POU domain, das 206 203
415823 R81864 Hs 205103 ESTs 205 1 87
412432 AA126311 Hs 9879 ESTs 205 248
421733 AL119671 Hs 1420 fibroblast growth fxtor rxeptor 3 (xh 203 220
414876 AW950925 Hs 924 crystallm, mu 202 230
432306 Y18207 Hs 303090 protein phosphatase 1, regulatory (inhib 202 239
424010 AL080188 Hs 137556 Homo sapiens mRNA, cDNA DKFZp434A132 (fr 1 95 272
453317 NM.002277 Hs 41696 keradn, hair, acidic, 1 1 95 266
452887 AI702223 Hs 107253 hypothedcal protein DKFZp761F241 1 88 285
410545 U32324 Hs 64310 interieukin 11 rxeptor, alpha 1 85 307
400496 ENSP00000224716* GTP-binding protein SAR 1 84 209
406972 M32053 gb Human H19 RNA gene, complete eds 1 83 414
406266 Target Exon 1 75 238
414309 AK000639 Hs 75884 DKFZP586A011 protein 1 73 280
416250 AA581386 Hs 73452 hypothedcal protein MGC10791 1 72 227
451849 AI199261 Hs 27191 hypothedcal protein from clone 24796 1 70 209
441134 W29092 Hs 346950 cellular retinoic xid-bmdiπg protein 1 1 68 237
401963 NM.006311 Homo sapiens nuclear rxeptor 1 66 238
430947 U01212 Hs 248153 oKxtoiγ marker protein 1 65 200
413391 AI223328 Hs 75335 glycine amidinotransferase (L-argmine g 1 63 2 18
406387 Target Exon 1 57 2 14
405776 cytxhrome c-1 1 55 2 23
410677 NM.O03278 Hs 65424 tetranxdn (plasminogen-bindmg protein 1 53 326
406807 AA057605 Hs 180920 πbosomal protein S9 1 53 267
420438 AW403621 Hs 1311 CD1C andgen, c polypepdde 1 52 209
422089 AA523172 Hs 103135 ESTs, Weakly similar to SFR4.HUMAN SPLIC 1 52 2 66
456898 NM 001928 Hs 155597 D ∞mponent of complement (adipsin) 1 48 257
402412 Target Exon 1 48 242
427795 BE268268 Hs 180842 πbosomal protein L13 1 48 348
452547 AA335295 Hs 74120 adipose spxific 2 1 47 389
414323 NM.014759 Hs 334688 KIAA0273 gene product 1 46 3 14
425831 U46689 Hs 159608 aldehyde dehydrogenase 3 family member 1 45 209
457090 AL080243 Hs 180920 nbosomal protein S9 1 40 286
445431 AF137386 Hs 12701 plasmolipm 1 39 200
445636 AW105401 πbosomal protein L29 1 38 208
414682 AL021154 Hs 76884 inhibitor of DNA binding 3, dominant πeg 1 37 3 32
406845 AI567284 Hs 119598 πbosomal protein L3 1 37 204
406808 AI690307 Hs 180920 πbosomal protein S9 1 36 332
403986 Target Exon 1 34 209
402218 NM.022165' Homo sapiens ϋn-7b protein ( 1 31 2 16
400649 Target Exon 1 29 2 07
432647 AI807481 Hs 278581 fibroblast growth fxtor rxeptor 2 (bx 1 28 240
403211 NM.005400* Homo sapiens protein kinase C 1 26 2 13
452678 AI243131 Hs 164661 ESTs, Weakly similar to TGLX.HUMAN PROTE 1 26 2 14
406889 D50310 Hs 79933 cyclm I 1 26 2 37
447299 AF043897 Hs 18075 chromosome 9 open reading frame 3 1 25 239
404406 Target Exon 1 24 209
432894 AW167668 Hs 279772 bran spxific protein 1 23 228
406757 T65957 Hs 77039 ATP synthase, H transporting, mitxhondr 1 21 201
425883 AL137708 Hs 161031 Homo sapiens mRNA, cDNA DKFZp434K0322 (f 1 20 207
409726 AI479341 Hs 724 thyroid hormone receptor, alpha (avian e 1 17 262
436398 H87136 Hs 5174 nbosomal protein S17 1 17 242
444674 BE562200 Hs 244 ammo-terminal enhancer of split 1 16 202
402450 Target Exon 1 16 208
406758 AA552326 Hs 77039 ATP synthase, H transporting mitxhondr 1 16 2 03
431243 U46455 Hs 252189 syndxan 4 (amphiglycan, ryudxan) 1 13 2 23
407032 U73799 gb Human dynxdn mRNA, partial eds 1 10 201
402921 ENSP00000244047- Cadhenn-like protein V 1 00 200
TABLE 61B
Pkey Unique Eos probeset identifier number
CAT number Gene cluster number
Axession Genbank axession numbers
Pkey CAT Number Accession
431089 125941.2 BG940189 AW063489 AA715980 BF001091 BF880066 AA666102 AA621946 AA491826 456034 685586.1 AA136653 AA136656 AW450979 AA984358 AA809054 AW238038 AA492073 BE168945 459702 539529.1 BG207209 BE166299 AI204995 BG199355 AW969908 AA528756 AW440776 BI044354
445636 8561.5 BF339388 AI345516 BG391657 BE708967 BG026034 BE261703 H56716 H65572 H93801 T48830 R96953 R96989 R39707 BE867593 AA090310
AA090672
TABLE 61C Pkey Unique number conesponding to an Ex probeset Ref Sequence source The 7 digit numbers in this ∞lumn are Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publication endtled "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Sfrand Indicates DNA strand from which exons were predicted
NLposition i Indicates nudeodde positions of predicted exons
Pkey Ref Strand NLposidon
402880 9926561 Minus 4155541865
402525 9800048 Minus 1974520683
400496 9743564 Plus 4151541695
406266 7528342 Minus 23652518
401963 3126783 Plus 51382-51521
406387 9256180 Plus 116229-116371,117512-117651
405776 7159748 Minus 105911-107251
402412 7408036 Plus 7507575679
403986 8576059 Plus 90692-91238
402218 7689783 Plus 127677-127886
400649 8117705 Plus 93097-93792
403211 7630841 Minus 159211-159369
404406 7329316 Minus 4754547928
402450 9796674 Plus 137535137682, 137920-138045
402921 7981303 Minus 52242-52384,55599-55858,57124-57309,5963
TABLE 62A ABOUT 121 GENES UPREGULATED IN BENIGN NEVI RELATIVE TO NORMAL SKIN
Table 62A lists about 121 genes upregulated in benign nevi reladve to normal skin These genes were selxted from 59680 probesets on the Eos/Affymetnx Hu03 Genxhip array
Gene expression data for exh probeset obtaned from this analysis was expressed as average intensity (Al) a normalized value reflxdng the reladve level of mRNA expression
Pkey Unique Eos probeset idendfier number
ExAxn Exemplar Axession number, Genbank axession number
UnigenelD Unigene number
Unigene Title Unigene gene dde
R1 average of benign nev i Als divided by the 90th percendle of nomial skin Als
R2 average of benign nev i Als divided by the 90th percendle of normal skin Als, wt numerator and denominator
Pkey ExAxn UnigenelD Unigene Title R1 R2
430377 NM 001922 Hs 301865 dopxhrome tautomerase (dopxhrome delta 869 766
438380 T06430 Hs 6194 chondroidn sulfate proteoglycan BEHAB/b 671 8 11
406964 M21305 FGENES predicted novel sxreted protein 650 3 35
426555 NM 000372 Hs 2053 tyrosinase (xulxutaneous albinism IA) 640 4 32
430822 AJ005371 Hs 248017 glyceraldehyde-5phosphate dehydrogenase 516 412
415752 BE314524 Hs 78776 putadve transmembrane protein 477 359
431103 M57399 Hs 44 pleiotrophin (hepann binding growth fx 463 499
451668 Z43948 Hs 326444 cartilage acidic protein 1 462 604
449644 AW960707 Hs 148324 ESTs 397 341
435056 AW023337 Hs 5422 gly∞protem M6B 342 229
431089 BE041395 ESTs, Weakly simila to unknown protein 321 257
452973 H88409 Hs 40527 ESTs 316 312
408393 AW015318 Hs 23165 ESTs 3 12 200
417355 D13168 Hs 82002 endothelin rxeptor type B 3 11 245
415314 N88802 Hs 5422 glycoprotein M6B 286 239
417632 R20855 Hs 5422 glycoprotein M6B 278 2 16
457211 AW972565 Hs 32399 ESTs, Weakly similar to S51797 vasodilat 275 371
456034 AW450979 gb UI H-BI5ala-a-12-0-UI s1 NCI_CGAP.Su 273 300
404356 Target Exon 263 269
414876 AW950925 Hs 924 crystallm, mu 257 315
420208 BE276055 Hs 95972 silver (mouse homolog) like 246 289
422656 AI870435 Hs 1569 LIM hom∞box protein 2 245 220
439963 AW247529 HS 6793 platelet-activating fxtor xetylhydrola 243 211
432222 AI204995 gb an03c03 x1 Stratagene schizo bran S1 231 1 96
401116 Target Exon 229 224
410326 AI368909 Hs 47650 ESTs 227 277
459702 AI204995 gb an03cO3 x1 Stratagene schizo brain S1 225 349
435730 AB020635 Hs 4984 KIAA0828 protein 224 224
404977 Insulin-like growth fxtor 2 (somatomedi 224 1 99
414221 AW450979 gb UI-H-BI3-ala-a-12-0-UI s1 NCI.CGAP.Su 216 236
437862 AW978107 Hs 5884 Homo sapiens mRNA, cDNA DKFZp586C0224 (f 2 13 209
402181 Target Exon 212 274
447907 AI439110 Hs 1707% ESTs 205 202
434276 AF123659 Hs 93605 leucine zipper, putative tumor suppresso 204 3 14
459246 NM.006834 Hs 32217 RAB32, member RAS oncogene family 202 1 83
405451 dihydropyπmidinase-like 3 201 200
446727 AB011095 Hs 16032 KIAA0523 protein 201 2 36
417017 AA976064 Hs 180842 nbosomal protein L13 200 237
413171 AA318325 Hs 75219 tyrosinase-related protein 1 1 94 2 77
408209 NM 004454 Hs 43697 ets vanant gene 5 (ets-related molxule 1 94 276
455657 BE065209 gb RC1-BT0314-310300-015b12 BT0314 Homo 1 92 291
419200 AW966405 EST 1 85 291
419687 AI638859 Hs 227699 ESTs, Weakly similar to T2D3 HUMAN TRANS 1 84 227
402217 C19001662* gι|6753872|ref|NP_034345 1| i 1 83 233
406040 Target Exon 1 81 204
435292 N20514 Hs 172965 ESTs 1 81 341
430947 U01212 Hs 248153 olfxtory mar er protein 1 79 200
434574 AI424458 Hs 33470 ESTs 1 78 400 403532 NM.024638 Homo sapiens hypothedcal prot 1 75 206
402829 C1002500 gι|6754254|reflNP_034610 1| hea 1 72 220
403828 C4000447* gι|7705570|reflNP_038851 1| KI 1 72 204
453837 AL138387 Hs 256126 bxuloviral IAP repeat-contanmg 7 (liv 1 68 2 40
407826 AA128423 Hs 40300 calpan 3, (p94) 1 67 2 13
441253 AI632744 Hs 129501 ESTs 1 67 213
405776 cytxhrome c-1 1 66 236
430540 AW245422 Homo sapiens cDNA FLJ22105 fis, ctone H 1 66 208
445745 AB007924 Hs 13245 KIAA0455 gene product 1 66 234
401963 NM_006311 Homo sapiens πudear receptor 1 66 297
402994 NM_002463* Homo sapiens myxovirus (influ 1 66 256
406016 Target Exon 1 65 223
429186 BE503443 Hs 112095 hypothedcal protein OKFZp434F1819 1 65 230
402911 NM_021158* Homo sapiens protein kinase d 1 63 246
412926 AI879076 Hs 75061 mxrophage myπstoylated alan e-nch C 1 61 228
440437 AI923201 Hs 192352 ESTs 1 59 207
403960 ENSP00000174317* KIAA0303 (FRAGMENT) 1 59 241
406266 Target Exon 1 56 216
424481 R19453 Hs 1787 proteolipid protein 1 (Pelizaeus-Merzbx 1 55 3 14
403803 C4001432* gι|6009515|dbj|BAA84941 1| (AB 1 54 204
407038 X00237 gb Human F vaπable segment 5' to aπdth 1 53 209
424412 H15512 Hs 10043 hypothedcal protein FU 13074 1 53 246
431836 AF178532 Hs 271411 beta-site APP-cleaving enzyme 2 1 52 2 76
427923 AW274357 Hs 301406 hypothedcal protein PP3501 1 52 304
419849 BE041436 Hs93379 eukaryotic transladon inidadon fxtor 1 51 342
404790 C12001707* gι|7305215|reflNP_038599 1| k 1 50 216
434596 T59538 gb yb65g12 s1 Stratagene ovaγ (937217) 1 48 202
425069 AA687465 Hs 298184 potassium voltage-gated channel, shaker- 1 47 405
438549 BE386801 Hs 21858 tπnucleodde repeat containing 3 1 46 248
427289 AI097346 phosphosenne aminotransferase 1 44 446
425818 AB021225 Hs 159581 matnx metalloproteinase 17 (membrane-in 1 43 2 32
432800 BE391046 Hs 278962 AIM-1 protein 1 43 208
447763 BE619911 Hs 115803 hypothedcal protein 1 42 2 21
443219 AI354669 Hs 187461 ESTs, Weakly simila to C29149 proline-r 1 41 231
451489 NM.005503 Hs26468 amyloid beta (A4) precursor protein-bind 1 41 235
459641 AW064121 Hs 279175 ESTs 1 41 201
405318 C7002129* gι|3638957|gb|AAC36301 1| (AC0 1 40 231
402343 Target Exon 1 40 235
447108 AW449602 Hs 241493 natural killer-tumor rxognidon sequenc 1 40 2 11
431222 X56777 Hs 273790 zona pelluαda glycoprotein 3A (sperm re 1 39 206
400263 Eos Control 1 39 260
403986 Taiget Exon 1 38 209
437912 BE278594 Hs 5912 F-box only protein 7 1 36 227
426020 AL110195 Hs 166017 microphthalmia-assxiated transcnpdon 1 36 277
401914 Target Exon 1 33 243
450395 BE048545 Hs 161757 ESTs 1 29 201
425535 AB007937 Hs 158287 KIAA0468 gene product 1 29 294
450358 AB010098 Hs 24907 coronin, xdn-bindmg protein, 2B 1 28 284
427560 AA405394 Hs 161851 ESTs 1 27 2 14
402450 Target Exon 1 27 289
406885 D28423 gb Human mRNA for pre-mRNA splicing fxt 1 26 3 19
404067 Target Exon 1 26 2 45
406368 NMJ22355 Homo sapiens putative dipepdd 1 25 206
454429 BE273437 Hs 301406 hypothedcal protein PP3501 1 23 207
414580 BE386918 gb 601275386F1 NIH_MGC_20 Homo sapiens c 1 22 2 21
414060 BE246327 Hs 123164 gb TCBAP1E1967 Pediatnc pre-B cell xut 1 22 201
400867 ∞film 1 (non-muscle) 1 21 219
437026 AW976573 ESTs 1 21 231
402605 Target Exon 1 20 209
431008 H84058 Hs 25734 ESTs, Weakly similar to BING1 (H sapiens 1 17 222
448143 AF039704 Hs 20478 ceroid-lipofuxmosis neuronal 2, late 1 17 2 25
416630 H69392 Hs 174051 small nuclea nbonucleoprotein 70kD pol 1 16 234
407239 AA076350 Hs 67846 leukxyte immunoglobulm-like rxeptor, 1 14 258
419045 T85693 gb yd60d06 r1 Soares fetal liver spleen 1 13 208
443923 X60702 Hs 210 leukxyte tyrosine kinase 1 11 2 24
457585 AB040799 Hs 278283 G protein-coupled rxeptor 27 1 08 204
452958 AA883929 Hs 40527 ESTs 1 03 2 28
403969 ENSP00000034663 Zinc finger protein 131 1 00 204
436878 BE465204 Hs 47448 ESTs 1 00 2 12
415929 AA724373 Hs 49344 hypothetical protein FU11006 1 00 2 18
404632 NM J22490 Homo sapiens hypothedcal prot 1 00 2 19
452838 U65011 Hs 30743 preferentially expressed andgen in mela 1 00 235
447937 AL109716 Hs 20034 Homo sapiens mRNA full length insert cDN 1 00 241
TABLE 62B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Accession Genbank axession numbers
Pkey CAT Number Axession
431089 125941.2 BG940189 AW063489 AA715980 BF001091 BF880066 AA666102 AA621946 AA491826
456034 685586 AA136653 AA136656 AW450979 AA984358 AA809054 AW238038 AA492073 BE168945
432222 539529.1 BG207209 BE166299 AI204995 BG199355 AW969908 AA528756 AW440776 BI044354 459702 539529 BG207209 BE166299 AI204995 BG199355 AW969908 AA528756 AW440776 BI044354
414221 685586.1 AA136653 AA136656 AW450979 AA984358 AA809054 AW238038 AA492073 BE158945
455657 1490185.1 BE0652098E065364 BE065110 BE065111
419200 9531.1 BF036043 AW190446 BG194731 AW662036 AI445021 8E937550 AW818972 AW393132 AA834685 BF112058 AV721682 H16423 AI270167 AI857345
AA937302 AW818444 BE929780 BG498678 BF155010 BI598271 BI599811 BE161728 AW578737 AW753711 AW379707 AW381918 BG506608 AW028637 AW994240 BF887392 BF790073 AW381624 AV727105 BF439618 AA443174 AI018009 N42850 AW573242 AI417258 AA463483 AI676131 AI167170 AA836627 AA443828 AW592922 AA235129 AA730278 AW439062 AW474332 BI043239 AW474342 BG708553 AW362423 BF090028 BE827256 R16550 R39478 R39479 R94368 BG540916 BM314745 AA251087 D54231 D55274 BF085805 D31589 AW966405 AW994425 D81879 BE093545 AW901107 AA383529 BI021552 R56420 N39976 AA573281 H82595 AA234955 BE093539 AW367006 BF358697 BF366318 AA663856 BE702099 BF035969 Al 267384 AI267232 BE348320 AA621574 AA861212 BF083343 BF083341 AV745131 D53074 AW954476 AW954472 AA376836 AV724531 D53063 C14928 AA093287 AA062638 BG483558 BE940050 AA765954 T70171 BE938775 BE940057 D53502 AW373300 AL118798 B 128728 AA193411 AW444709 AW952455 AI887612 BF431948 BI496876 AI264159 B 128481 AI624657 AI689301 AI969467 AA861685 AA2S1595 AA625761 AA872090AI826790 AA328366 BE827416 R75951 D56918 R68122 BE827384 AL118797 AI184164AA164411 BI495332 BE858113 AI863860 H00660 T69849 AW780389 C14667 BE93499581018652 R92801 AA164410 H00752 AW373305 AW373299 AW373302
430540 713.2 BC017171 BC012195 NM.007126 AF100752 AL137377 Z70768 BM474865 BG754806 AU124376 BG757203 BG764420 BG775028 BG824418
BM045810 AU120387 BG770238 BG686740 BG913323 BI759980 BG395998 BM048875 BE881070 BE313689 BE879144 BM309834 AW245847 AI770171 BF196861 BE856897 AA463876 AI375927 AA648810 AA948193 AA490916 AI459893 AI458188 AI240408 AI191843 AI131029 AW768399 AI365196 AW337984 AW026150 BE466591 BE674599 AI818438 AA772197 AI651927 AW151143 BI198825 BG819083 BM458764 BE903567 BE732715 BM043200 BE900263 BE900706 BE731097 BE390023 BG875384 BF996406 BF988930 BM475542 AW246215 BE501897 BE903610 BE561530 BE560537 BE903782 BE732947 BI227204 BG761305 BE262642 BE391848 BE382475 BG008258 BI547991 BI459099 BE391391 BE259420 BE298109 AW245422 AI423847 AI914618 H80534 BE301004 AL531791 AI435581 BF793112 AL577303 AA373265 BE746965 BF743630 BE879296 AI359493 BM018598 AI689260 AW072450 F20201 AW151405 AW517572 AA773468 BG259694 BE391163 BG621529 AI421728 BG767231 BM462953 BG340524 W52648 AA113434 BE785431 BI041981 BG832385 BG253168 BG759470 BF369329 BF981332 BE259418 BE785738 BI091658 N72512 W58732 W85690 BG958989 AI205206 H19721 W17051 W77958 BI262010 AA844319 W74143 W72214 N85194 BE734033 BG164099 AA931069 F13645 R41394AK025758 BG180977 BE349455 AA812018AA740241 AI027722AI150356AA886395AW977627 BE220225AA884082AW518114 AI243844 AA809493 AA481029 AA825718 AI347866 AI431670 AA814436 AI251109 R07704 AA765606 AA724593 AI918399 AI537550 AA491103 AW008188 R07703 AA989120 AA746235 AW028983 AA789102 AU185751 AW971465 AA489681 AW971893 AW612086 BE077936 BI860809 BE002760 BG746251 BE962912 BM454584 AL134894 BF104082 H80591
434596 14701.1 AF147374 T59538 T59589 T59598 T59542
427289 1820.2 BC007350 BG766159 BG769338 BG761999 BG744385 BG770572 AW370610 AW370581 AA978353 AW327973 AW402425 AI889380 AA868504
AW612968 AA630644 AI751211 N26980 Al 394506 AA747849 BF154926 BF477185 AA649647 R39135 AI750216 T35363 W36278 AW079375 AW612240 AA505495 AA515380 BG760793 AW370651 BG766029 AW370595 BF229885 BG762422 BG764907 T50662 AA025671 AW815715 AV703420 H65047 AA485582 R56186 H90385 R55913 BI261497 BI018403 BF376945 T75578 BF933325 BF932853 BG502266 AW868934 AV683504 BI018121 N41953 BF933343 BF932871 H08334 R14012 BF897622 T50816 BG698803 BF340083 Z20199
400263 18977.1 Z11692 X51466 NM.001961 M19997 BI224253 BG830478 AU122147 AU123437 BG113591 BG752624 BE886804 BI868669 BG337216 AW629935
BM016525 AI560409 AL562866 AI909178 BF849556 AA371735 BF038841 BF727115 BC006547 BG757526 AL555664 BI261304 BG770095 BI033486 BI517580 BG876486 BI011828 AI313235 BG831724 BF869862 BG998348 BI011834 BF888337 BF898627 BF092380 AW803215 F01241 BF805719 BG876487 AW498536 BF988866 BG998849 AA248724 BG829202 BG756456 BG032392 BI859287 BM016990 BG332369 BE933685 BE166758 BM452445 AI937808 AW026128 N23684 AW006041 AI337621 F33111 BF344301 BG105450 BG387343 BF569547 BF154671 BM007368 BF569385 BE772007 BI199487 BF761700 BI261519 BF944452 BF898506 AI038390 BM044934 AW381142 BG743618 BE769206 BE893973 BI015047 BF886479 BF761350 BE769769 BG766117 BF847365 BE397834 AW371121 BF089125 BE082996 BF183193 BG180964 BF089940 BI000274 BG255503 BG674499 BG774174 BI015084
414580 623093 1 BG333973 BE385437 BE408833 BE387650
437026 1240260 1 AW976573 AA742335 AA830000
419045 348516 2 BF981324 BG723297 T85693 T81681 T81909
TABLE 62C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column ae Gent sequence of human chromosome 22" Dunham, et al (1999) Na
Strand Indicates DNA strand from which exons were predicted
NLposition i Indicates nucleotide positions of predicted exons
Pkey Ref Strand Nt posidoπ
404356 7630858 Minus 126435126623
401116 9966559 Plus 123579-124447
404977 3738341 Minus 43081-43229
402181 8575912 Plus 449745450040
405451 7622517 Minus 145949-146227
402217 9795981 Minus 21521-21757
406040 6758938 Minus 2306523599
403532 8076842 Minus 81750-81901
402829 8918414 Plus 101532-101852,102005102263
403828 9838214 Plus 3175532148
405776 7159748 Minus 105911-107251
401963 3126783 Plus 51382-51521
402994 2996643 Minus 47274969
406016 8272661 Plus 41341-41940
402911 7263904 Plus 142685142979
403960 8224409 Minus 90999-94843
406266 7528342 Minus 23652518
403803 8112965 Plus 5551555778
404790 7230958 Plus 38611-38761
405318 3638954 Plus 79689-79967
402343 8099256 Plus 4677-6084
403986 8576059 Plus 90692-91238
401914 9369520 Plus 62537-62945,6315563308
402450 9796674 Plus 137536137682,137920-138045
404067 3282162 Plus 14152071
406368 9256126 Minus 72447-72588,7267572802.7311573245
400867 9838275 Plus 3413534846
402605 9909420 Minus 4768547973
403969 8569909 Plus 31237-31375,3240532506 404632 9796668 Plus 4509545229
TABLE 63A ABOUT 181 GENES UPREGULATED IN BENIGN NEVI RELATIVE TO MELANOMA METASTASES
Table 63A lists about 181 genes upregulated in benign nevi reladve to melanoma metastases Genes were selxted from 59680 probesets on the Eos/Affymetox Hu03 Genxhip array Gene expression data for exh probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflxdng the relative level of mRNA expression
Pkey Unique Eos probeset idendfier number
ExAxn Exemplar Axession number, Genbank axession number
UnigenelD Unigene number
Unigene Tide Unigene gene dde
R1 average of benign nevi i Als divided by the 90th percendle of melanoma metastasis Als
R2 average of benign nev i Als divided by the 90th percendle of melanoma metastasis Als, where the 15th per the numerator and denominator
Pkey ExAxn UnigenelD Unigene Tide R1 R2
401781 Target Exon 1933 1921
422511 AU076442 Hs 117938 ∞llagen, type XVII, alpha 1 13 54 14 18
401780 NM_005557* Homo sapiens keradn 16 (foca 1297 1363
409601 AF237621 Hs 80828 keradn 1 (epidermolydc hyperkeratosis) 1261 31 19
412636 NM 004415 desmoplakin (DPI, OPII) 11 73 691
420783 AI659838 Hs 99923 Ixdn, galxtoside-binding, soluble, 7 10 18 1408
409632 W74001 Hs 55279 senne (or cysteine) proteinase inhibito 848 679
421733 AL119671 Hs 1420 fibroblast growth fxtor rxeptor 3 (xh 8 28 962
430686 NM 001942 Hs 2633 desmoglem 1 726 564
429852 AB010445 Hs 225948 small inducible cytokine subfamily A (Cy 712 10 88
442577 AA292998 Hs 163900 ESTs 701 659
406964 M21305 FGENES predicted novel sxreted protein 650 882
401785 NM_0O2275* Homo sapiens keradn 15 (KRT1 640 977
410001 AB041036 Hs 57771 kallikrein 11 6 18 6 16
417515 L24203 Hs 82237 ataxia-telangixtasia group D-assxiated 573 16 57
418686 Z36830 Hs 87268 annexin A8 532 5 27
439496 BE616501 Hs 32343 Homo sapiens, Similar to RIKEN cDNA 1110 489 981
452240 AI591147 Hs 61232 ESTs 489 667
402525 NM_002699* Homo sapiens POU doman, as 474 4 80
431360 NM 000427 Hs 251680 loπcnn 466 398
431103 M57399 Hs 44 pleiotrophin (hepann binding growth fx 463 569
418067 AI127958 Hs 83393 cystadn E/M 456 678
424012 AW368377 Hs 137569 tumor protein 63 kDa with strong homolog 456 573
418663 AK001100 Hs 41690 desmxollin 3 444 523
419329 AY007220 Hs 288998 S100-type calcium binding protein A14 424 649
439706 AW872527 Hs 59761 ESTs, Weakly similar to DAP1 HUMAN DEATH 395 3 37
421773 W69233 Hs 112457 ESTs 388 960
408536 AW381532 Hs 135188 ESTs 382 10 18
418394 AF132818 Hs 84728 Kruppel like fxtor 5 (intestinal) 378 633
408000 L11690 Hs 198689 bullous pemphigoid andgen 1 (230/240kD) 3 77 492
432374 W68815 Hs 301885 Homo sapiens cDNA FLJ11346 fis, clone PL 370 530
424049 AB014524 Hs 138380 KIAA0624 protein 368 441
421948 L42583 Hs 334309 keradn 6A 362 3 13
427666 AI791495 Hs 180142 calmodul -like skin protein (CLSP) 359 4 40
422168 AA586894 Hs 112408 S100 calcium-binding protein A7 (psonas 348 609
436895 AF037335 Hs 5338 carbonic anhydrase XII 342 328
437191 NM_006846 Hs 331555 senne protease inhibitor Kazal type, 5 328 389
401760 Target Exon 3 21 7 11
431089 BE041395 ESTs, Weakly similar to unknown protein 321 578
434293 NM 004445 Hs 3796 EphB6 3 14 3 11
412432 AA126311 Hs 9879 ESTs 314 485
442503 AF147078 Hs 150853 p53-responsιve gene 5 3 11 592
414987 AA524394 Hs 294022 hypothedcal protein FU 14950 307 489
420798 W93774 Hs 99936 keradn 10 (epidermolydc hyperkeratosis 299 309
433339 AF019226 Hs 8036 glioblastoma overexpressed 296 275
414876 AW950925 Hs 924 crystallin, mu 294 3 82
437233 D81448 Hs 339352 Homo sapiens brother of CDO (BOC) mRNA, 287 342
424897 D63216 Hs 153684 fπzzled-related protein 287 1 96
456034 AW450979 gb Ul-H-BI3-ala-a-12-0-UI s1 NCI_CGAP_Su 273 254
424364 AW383226 Hs 163834 ESTs, Weakly similar to G01763 atrophιn- 272 292
427318 AF186081 Hs 175783 zmc transporter 271 221
452887 AI702223 Hs 107253 hypothetical protein DKFZp761F241 267 647
452308 AI167560 Hs 61297 ESTs 267 4 61
407788 BE514982 Hs 38991 S100 calcium-binding protein A2 264 268
431369 BE184455 Hs 251754 sxretory leukocyte protease inhibitor ( 2 57 391
451541 BE279383 Hs 26557 plakophilin 3 249 547
453317 NM 002277 Hs 41696 keratin, hair acidic 1 245 4 17
412633 AF001691 Hs 74304 penplakin 242 490
417233 W25005 Hs 24395 small inducible cytokine subfamily B (Cy 241 268
424797 AA622394 Hs 153177 πbosomal protein S28 2 39 267
424010 AL080188 Hs 137556 Homo sapiens mRNA, cDNA DKFZp434A132 (fr 2 39 407
453241 H58995 Hs 37648 ESTs 239 234
426451 AI908165 Hs 169946 GATA binding protein 3 (T-cell rxeptor 236 1 88
423467 AK0O0214 Hs 129014 hypothetical protein FU20207 2 32 224
432222 Al 204995 gb an03c03 x1 Stratagene schizo brain S1 2 31 1 99
430168 AW968343 Hs 145582 DKFZP434I1735 protein 230 260
457121 AI743770 Hs 180513 ESTs Weakly similar to KIAA0822 protein 2 28 1 91 433091 Y12642 Hs 3185 lymphxyte andgen 6 complex, Ixus D 2 27 850
446989 AK001898 Hs 16740 hypothedcal protein FU11036 227 221
429365 AA451798 Hs 99249 ESTs 2 25 254
459702 AI204995 gb an03c03 x1 Stratagene schizo brain S1 2 25 235
420511 AF052692 Hs 98485 gap junction protein, beta 3, 31kD (∞nn 2 23 2 17
444946 AW139205 Hs 156457 hypothetical protein FU22408 2 23 323
417017 AA976064 Hs 180842 πbosomal protein L13 221 274
433124 U51712 Hs 13775 hypothetical protein SMAP31 2 21 1 68
430152 AB001325 Hs 234642 aquapoπn 3 220 332
444726 NM.006147 interferon regulatory Ixtor 6 2 15 520
454034 NM 000691 Hs 575 aldehyde dehydrogenase 3 family, member 215 282
425483 AF231022 Hs 158159 FAT tumor suppressor (Drosophila) homdo 2 14 296
419912 AF249745 Hs 6066 Rho guanine nudeodde exchange fxtor ( 2 14 225
431441 U81961 Hs 2794 sodium channel, nonvoltage-gated 1 alpha 2 12 299
444105 AW189097 ESTs 2 11 298
428748 AW593206 Hs 98785 Ksp37 protein 209 1 51
456826 AI871742 Hs 302428 wingless-type MMTV mtegradon site fami 209 3 25
413163 Y00815 Hs 75216 protein tyrosine phosphatase, receptor t 209 497
410677 NM 003278 Hs 65424 tetranxtin (plasminogen-bmding protein 206 568
430285 AI917602 Hs 106440 ESTs 206 204
444781 NM 014400 Hs 11950 GPI-anchored metastasis-assxiated prote 205 592
451668 Z43948 Hs 326444 cartilage xidic protein 1 204 2 19
441134 W29092 Hs 346950 cellular rebnoic xid-bindmg protein 1 204 308
433428 T29975 Hs 33104 Hundngdn interxdng protein C 204 1 63
425831 U46689 Hs 159608 aldehyde dehydrogenase 3 family, member 203 392
446727 AB011095 Hs 16032 KIAA0523 protein 201 260
431703 AA514264 Hs 4437 tπosephosphate isomerase 1 201 205
452554 AW452434 Hs 58006 ESTs, Weakly similar to ALU5_HUMAN ALU S 1 99 404
439625 AF086453 Hs 58611 ESTs 1 99 2 31
402880 Target Exon 1 99 275
428471 X57348 Hs 184510 sfratifin 1 98 2 10
413859 AW992356 Hs 8364 Homo sapiens pyruvate dehydrogenase k a 1 97 316
452547 AA335295 Hs 74120 adipose spxific 2 1 95 389
437679 NM 014214 Hs 5753 ιnosιtol(myo) 1(or4)-monophosphatase 2 1 94 206
429259 AA420450 Hs 292911 Plakophilin 1 93 296
406387 Target Exon 1 92 297
455797 BE091833 gb IL2-BT0731-260400-075F04 BT0731 Homo 1 91 346
437202 AA326110 nuclea transcnpdon fxtor Y, gamma 1 89 200
426150 NM 003658 Hs 167218 BarH-hke homeobox 2 1 86 260
434574 AI424458 Hs 33470 ESTs 1 85 461
446051 BE048061 Hs 37054 ephnn-A3 1 85 348
424471 AA341329 Hs 311524 ESTs 1 84 262
422106 084239 Hs 111732 Fc fragment of IgG binding protein 1 83 469
451721 NM 006946 Hs 26915 spxtnn, beta, non-eiythrxydc 2 1 82 200
451849 AI199261 Hs 27191 hypothedcal protein from clone 24796 1 81 231
429348 AJ242859 Hs 199731 Langerhans cell spxific c type Ixdn 1 79 307
423523 AW299828 Hs 193580 ESTs 1 77 337
432543 AA552690 Hs 152423 Homo sapiens cDNA FU21274 fis, clone C 1 76 246
403828 C4000447* gι|7705570|ref|NP 038851 1| KI 1 73 206
412446 AI768015 ESTs 1 68 316
420039 NM 004605 Hs 94581 sulfotransferase family, cytosolic, 2B, 1 67 222
411274 NM_002776 Hs 69423 kallikrein 10 1 66 2 26
401963 NM_006311 Homo sapiens nuclear rxeptor 1 66 252
435016 AI284219 Hs 130749 ESTs, Weakly similar to 138022 hypothed 1 65 220
437897 AA770561 Hs 146170 hypothetical protein FU22969 1 64 3 21
419648 T73661 Hs 91877 thyroid hormone responsive SP0T14 (rat) 1 63 294
410545 U32324 Hs 64310 interieukin 11 rxeptor, alpha 1 62 258
429211 AF052693 Hs 198249 gap junction protein, beta 5 (connexiπ 3 1 62 392
456898 NM 001928 Hs 155597 D component of complement (adipsm) 1 60 343
423526 AB011086 Hs 129739 KIAA0514 gene product 1 60 2 18
416305 AU076628 Hs 79187 coxsxkie vims and adenovims rxeptor 1 60 247
413966 AA133935 Hs 173704 ESTs, Moderately similar to A53959 throm 1 59 299
414217 AI309298 Hs 279898 Homo sapiens cDNA FLJ23165 fis, clone L 1 59 282
429299 AI620463 Hs 347408 hypothetical protein MGC13102 1 57 264
432647 AI807481 Hs 278581 fibroblast growth fxtor rxeptor 2 (bx 1 56 274
429002 AW248439 Hs 2340 juncdon plakoglobm 1 56 297
430171 AF086289 Hs 234766 skm-spxific protein 1 54 218
422717 AI557623 Hs 119475 cold inducible RNA-bindmg protein 1 51 2 19
414323 NM 014759 Hs 334688 KIAA0273 gene product 1 51 373
423184 NM 004428 Hs 1624 ephπn-A1 1 50 2 18
433101 AW572317 Hs 12082 Homo sapiens mRNA, cDNA DKFZp566L203 (fr 1 50 200
424362 AL137646 Homo sapiens mRNA, cDNA DKFZp586F0824 (f 1 48 204
433662 W07162 Hs 150826 RAB25 RAB2S, member RAS oncogene family 1 46 283
445431 AF137386 Hs 12701 plasmolipin 1 6 200
456906 AF117646 Hs 156637 Cas-Br-M (murine) xtropic retroviral tr 1 44 204
442599 AF078037 Hs 324051 RelA-assxiated inhibitor 1 42 350
445656 W22050 Hs 21299 ESTs. Weakly similar to AF151840 1 CGI 8 1 42 253
444672 Z95636 Hs 11669 laminin, alpha 5 1 0 236
447990 BE048821 Hs 20144 small inducible cytokine subfamily A (Cy 1 40 229
418462 BE001596 Hs 85266 integnn, beta 4 1 39 286
453023 AW028733 Hs 31439 senne protease inhibitor, Kunitz type, 1 38 228
416340 N31772 Hs 79226 fasciculation and elongation protein zet 1 38 224
433417 AA587773 Hs 8859 Homo sapiens. Similar to RIKEN cDNA 5830 1 38 2 14 407815 AW373860 Hs 183860 hypothedcal protein FU20277 1 36 234
432894 AW167668 Hs 279772 brain spxific protein 1 36 509
439733 AL365412 Hs 107203 hypothedcal protein from EUROIMAGE 1759 1 36 200
454478 AW805749 superoxide dismutase 2, mitochondrial 1 35 285
423515 AA327017 Hs 176594 ESTs 1 35 245
436663 AW410458 Hs 5258 chromosome 11 open reading frame2 1 35 207
404246 Target Exon 1 34 296
411939 AI365585 Hs 146246 ESTs 1 33 231
409178 BE393948 Hs 50915 kallikrein 5 1 33 203
427795 BE268268 Hs 180842 πbosomal protein L13 1 33 229
447299 AF043897 Hs 18075 chromosome 9 open reading frame 3 1 32 278
447330 BE279949 Hs 18141 ladinin 1 1 32 337
433399 N46406 Hs 84700 similar to phosphaddylcholme transfer 1 31 271
403986 Target Exon 1 31 209
407597 AA043925 Hs 339352 Homo sapiens brother of CDO (BOC) mRNA, 1 30 228
450796 NM_001988 Hs 25482 envoplakm 1 30 345
415550 L13720 Hs 78501 growth aπest-specific 6 1 29 276
415512 Y16270 Hs 78482 paralemmm 1 26 249
430513 AJ012008 Hs 241586 G6C protein 1 26 307
422581 NM 016339 Hs 118562 Unk guanine nudeodde exchange fxtor 1 23 204
420048 AW206824 Hs 25766 ESTs 1 23 201
425883 AL137708 Hs 161031 Homo sapiens mRNA, cDNA DKFZp434K0322 (f 1 23 222
430560 Z28942 Hs 243960 N-myc downstream-regulated gene 2 1 23 242
426377 AK001921 Hs 169575 hypothedcal protein MGC2550 1 23 220
402218 NM_022165* Homo sapiens ϋn-7b protein ( 1 23 201
413944 AW001579 Hs 9645 Homo sapiens mRNA for KIAA1741 protein, 1 18 224
414186 U33446 Hs 75799 protease, senne, 8 (prostasin) 1 16 2 16
426068 AF029778 Hs 166154 jagged 2 1 15 207
431243 U46455 Hs 252189 syndxan 4 (amphiglycan, rγudxan) 1 14 233
411388 X72925 Hs 69752 desmxollm 1 100 261
443672 AA323362 Hs 9667 butyrobetaine (gamma), 2-oxoglutarate di 1 00 263
TABLE 63B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Axession Genbank axession numbers
Pkey CAT Number Accession
412636 1438.1 M77830 NM.004415 AF139065 BG681115 BG740377 BI712964 BG000656 AA128470 E 1I43832
J05211 BG698865 BG740734 BG680618 BG739778 BI765807 BM353403 BM353248 AW177784 AW205789 AW951576 AW848592 BE182164 BF149266 BE940187 BI060445 BI060444 BF350983 BE720095 BE720069 BE715154 BE082584 BE082576 BE004047 AA857316 BI039774 BE713818 BE713548 AW170253 BE160433 BI039775 AW886475 BM462504 BE931734 BF149264 AA340777 BF381183 BG621737 AU127260 AW364859 BF993352 BG223489 BE819009 BF381184 BE715956 R58704 AA852212 AW366566 BI090358 BF087707 BE819046 BE819005 AA377127 BE073467 BE819069 BE819048 BI036306 BG990973 BI040954 BF919911 AU140155 AI951766 AI434518 AW804674 BF752969 BE837009 BE925826 BF149265 AW995615 BE814264 BI039782 AU140407 BE144243 BE709863 BF985642 BE001923 BF933510 AW265328 BG436319 BE182166 AW365175 AW847688 BE818280 AW177933 BF873679 AW178000 BE082526 BF476866 BF086994 BF592276 BE082507 BE082514 BE082505 BF873693 AW068840 AW847678 BF804153 AW365157 BE8139308E002030 AW365153 BE184941 BF749421 BE184920 BF839562 BE184933 BF842254 BE698470 BE931048 BF999889 BF368816 BE184924 BE159646 BE714632 BE184948 BG986845 AA131128 AA099891 W39488 C04715 BF096124 BE865341 AW799304 AL603116 BE149760 BE705967 BE705966 BE705968 AW848723 AW376699 AW376817 AW376697 BG005097 BF751115 BE696084 AW848371 AW376782 AW848789 AW849074 AW361413 BF927725 BF094211 AW997139 BE865474 BE185187 BE156621 BE715089 BE713297 BE713298 BE179915 AW799309 BF872345 BF088676 BE705939 AW752599 BG005197 BF350086 BE715196 BE715155 BF752396 BF093817 BF831190 BF752409 BE006561 BG959922 BF094833 BF094748 BF094583 AW377699 AW607238 BE082519 AW377700 BF349467 AI190590 AI554403 AI392926 AU158477 BI467252 AU159919 AI760816 BF082516 AI439101 AA451923 Al 340326 AI59097581791553 AI700963 AI142882 AA039975 AA946936 AA644381 BM314884 AA702424 AI417612 AW190555 AI220573 AI304772 AI270345 AI627383 AA552300 AI911702 AW166807 AI346078 W95070 AA149191 AA026864 AI830O49 AW780435 AI078449 AI819984 AI858282 BI468588 AI860584 AI025932 AA026047 AA703232 AA658154 AA515500 AW192085 AA918281 T77861 AI927207 AI205263 BF082491 AW021347 AI568096 BE939862 AA088866 D12062 AA056527 AA782109 W19287 W02156 AW150038 AA022701 T87181 H44405 AI910434 BF082513 AI494069 AI270027 AI635878 AA128330 BG681425 BE706078 R20904 BG680059 BG676647 BF764409 AA026654 AV74553081762796 BG287391 AW798780 BE706045 BE926470 AW799118 BF087996 BE002273 AW879451 AI571075 BE067786 AV721320 AI022862 N29754 C03378 N84767 AA131077 H30146 BE714290 AI686869 AI568892 AI915596 AW105614 AI887258 Al 538577 BE926474 BE067737 BG319486 AA247685 AW798883 AW103521 BF989173 AW860878 BE939707 BE185750 BE714064 BE713903 BE713868 BE713763 BG950164 BE713810 AW365151 BG955489 BE005272 BF915937 AW365148 AI905927 BF992780 AW853812 BG954443 BI770853 BG679406 BG740832 BG681087 BG698430 AA455100 T87267 BE696209 BE696210 BI089483 BE0O6273 BE872225 AW391912 BE925515 BG677012 BG741970 AA026480 BE705999 BG677157 BE009090 BG681378 BE712291 BG961498 BG678984 BI040941 AA337270 AW384371 AW847442 BI058659 BE813665W95048 W25458AW177786 AA025851 BE931733 BF154837 8G949393 BE714441 AW996245 BE711801 AI284090 BE064323 BE719390 BE940148 BG991212 BF375714 BF349522 BG996267 T48793 BI013292 BE001925 AW365156 AW365154 AW606653 BF763109 BE931637 BE167181 BE713879 BF354008 BF678726 H90899 AW365145 W38382 AI498487
431089 125941_2 BG940189 AW063489 AA715980 BF001091 BF880066 AA666102 AA621946 AA491826 456034 685586.1 AA136653 AA136656 AW450979 AA984358 AA809054 AW238038 AA492073 BE168945 432222 539529 BG207209 BE166299 AI204995 BG199355 AW969908 AA528756 AW440776 BI044354 459702 539529 BG207209 BE166299 AI204995 BG199355 AW969908 AA528756 AW440776 BI044354 444726 3503.2 BG285809 BE940673 BG432524 BE157554 BG676980 AU144284 AI745383 AU159045 AI693500 AW293668 AW371408 BE856107 AI338042 AW188320 AI698246 BE673290 AW297653 AA156532 AI017342 AI916754 AI190644 AI184302 AA857671 BE857018 AI307420 AI318157 AW204327 AW664668 AW274339 AA582788 AI 345741 AW301433 AI873468 AW137388 BF718731 BF718413AA877495 BF001575 AI824693AW849604 AW849405AW849396AW849173 BE673179 AI611327AA705753 BE715478AW849414AW849399AI085759AI140849 T67412AI889885AW104647 AI912495 AI889874 AI744241 BE717113 BE717108 BE715564 AI872527 AA029457 C00338 AI469558 BE715577 AA045413 BF843813
444105 649788.1 AW189097 Al 123917 Al 123926 455797 1511159.1 BE091833 BE091874 BE091871 437202 27670 1 AL110199 AL598719 AA152097 W84430 AI304351 BE670780 BF003019 AI271659 AW338914 AI127763 AI191873 AI922951 Al 568416 AI077680 AA358674 AI138802 Al 589070 AI088745 AW418696 BF475830 AI144150 AA724257 AA622339 AI375884 AI880453 AW874251 BF941345 AI619746 AI225114 AI801268AI554474 BM023333AI093946 AI699306 AI803839 AA496797 AI361531 AI123010 AW169313 B 023082 AI081626 AA513457 AA278720 AW518810 AA361091 AI499891 AI686346 BF436872 AI681496 AL572961 AI334148 AW138291 AI419063 AA278226 AA370719 AA152023 AI401749 AA127464 AL573761 BG913208 T07824 AI346417 H44939 AV721378 N48299 W72005 AA302424 AI611143 AW514684 BE041749 AW370992 R42918 H10757 R10703 C01061 R27637 AI827230 AW151953 AA651675 AA228006 AA233950 BE858910 R30801 W32704 H39784
BE090279 BG697660 AW877265 BI818938 BF528291 AW953624 R57461 BF969694
412446 63467.1 BC021735 AI669212 AL120184 AI769949 BE701002 BE184363 BE819031 BG702238 BF090049 BF963318 BF961912 BF943013 AA934514 AA151245
BF960659 AA987907241449 BF908059 BF908053 BF9080498E699424 BF908060 BF962832 BF952020 BF963134 BI035538 BF908052 BF908057
BF090026 BF943158 AI632924 BF512340 BF952021 BF960776 BF943437 BF942847 AI768015 F09778 F04816 F02721 AA102645 AI633838
AA617929 BF947001 BI0354488E935876 AW890837 AW898604 BF957405 BF963433 BG704815
424362 2318.7 AF284421 AL137646 BG542551 AI278088 AI423919 AI274095 BE838965 BE839174 BE839102 BF924520 BI913343 AW238809 AL134380 AW793289
AL534638 T97116 AW855182 C02210 AI783480 AW024874
454478 4273.16 AW796921 AW798102 AW805749 AW805872 8F985060 AW794380 BF380449 AW794466 AW794538
TABLE 63C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column ae Genbank Idendfier (Gl) numbers "Dunham, et al * refers to the publicadon endded "The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA strand from which exons were predicted NLposidon Indicates nudeodde positions of predicted exons
Pkey Ref Strand Nt position
401781 7249190 Minus 8321583435,83531-836568374583901,8423
401780 7249190 Minus 28397-28617,2892529045,2913529296,2941
401785 7249190 Minus 165775165996,166185166314,16640516656
402525 9800048 Minus 1974520683
401760 9929699 Plus 8312583250,8532585540,9471595287
402880 9926561 Minus 4155541865
406387 9256180 Plus 116225116371,117512-117651
403828 9838214 Plus 3175532148
401963 3126783 Plus 51382-51521
404246 7406725 Plus 82477-82628,82721-82817,82910-83071,8314
403986 8576059 Plus 90692-91238
402218 7689783 Plus 127677-127886
TABLE 64A ABOUT 929 GENES DOWNREGULATED IN PRIMARY MELANOMAS AND/OR MELANOMA METASTASES RELATIVE TO NORMAL SKIN Table 64A lists about 929 genes downregulated in pπmary melanomas and/or melanoma metastases reladve to noπnal skin Genes were selxted from 59680 probesets on the Eos/Affymetox Hu03 Genxhip array Gene expression data for exh probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflxdng the relative level of mRNA expression
Pkey Unique Eos probeset idendfier number
ExAxn Exemplar Axession number, Genbank axession number
UnigenelD Unigene number
Unigene Title Unige me gene dtle
R1 90th percendle of normal skin Als divided by the 90th percentile of pnmary
R2 90th percendle of normal skin Als divided by the 90th percendle of pπmaiy
Als was subtrxted from both the numerator and denominator
Pkey ExAxn UnigenelD Unigene Title R1 R2
420813 X51501 Hs 99949 prolactin-ind-iced protein 27 72 20 12
408591 AF015224 Hs 46452 mammaglobin 1 2640 2426
431360 NM.000427 Hs 251680 loπcπn 26 16 2045
401781 Target Exon 1968 19 56
412636 NM 004415 desmoplakin (DPI, DPII) 18 12 1036
429441 AJ224172 Hs 204096 lipophil B (uteroglobm family member) 1661 1806
418067 AI127958 Hs 83393 cystatm E/M 1600 2532
409632 W74001 Hs 55279 senne (or cysteme) proteinase inhibito 1564 11 81
409601 AF237621 Hs 80828 keradn 1 (epidermolydc hyperkeratosis) 1503 37 51
401780 NM_005557* Homo sapiens keradn 16 (fxa 14 20 1486
422168 AA586894 Hs 112408 S100 calcium-binding protein A7 (psonas 1395 2808
420783 AI659838 Hs 99923 Ixdn, galxtoside-biπdiπg, soluble, 7 1352 1885
422511 AU076442 Hs 117938 collagen, type XVII, alpha 1 13 14 1381
428330 L22524 Hs 2256 matπx metalloproteinase 7 (matπlysin, 1278 635
421733 AU 19671 Hs 1420 fibroblast growth fxtor rxeptor 3 (xh 1278 1522
428824 W23624 Hs 173059 ESTs 1267 1324
453309 AI791809 Hs 32949 defensin beta 1 1202 1242
446227 AI281459 Hs 270114 ESTs 11 79 1232
421948 L42583 Hs 334309 keradn 6A 11 58 902
432877 AW974111 Hs 292477 ESTs 11 18 11 30
412047 AA934589 Hs 49696 ESTs 11 04 11 07
407230 AA157857 Hs 182265 keradn 19 1079 11 40
421296 NM 002666 Hs 103253 penlipin 1073 794
410001 AB041036 Hs 57771 kallikrein 11 10 72 1070
418026 BE379727 Hs 83213 fatty xid binding protein 4, adipxyte 1033 716
447966 AA340605 Hs 105887 ESTs, Weakly similar to Homolog of rat Z 1009 967
401203 Target Exon 995 737
452308 AI167560 Hs 61297 ESTs 971 2005
425580 L11144 Hs 1907 galanin 966 841
433124 U51712 Hs 13775 hypothetical protein SMAP31 950 496
420919 M57892 Hs 100322 carbonic anhydrase VI 941 634
443162 T49951 Hs 9029 DKFZP434G032 protein 936 10 58
427666 AI791495 Hs 180142 calmodulm-like skin protein (CLSP) 9 19 11 73
431369 BE184455 Hs 251754 sxretory leukxyte protease inhibitor ( 885 17 76
408536 AW381532 Hs 135188 ESTs 882 2643
430686 NM 001942 Hs 2633 desmoglem 1 8 73 658
436895 AF037335 Hs 5338 carbonic anhydrase XII 869 681
418663 AK001100 Hs 41690 desmxollm 3 861 9 15 429852 AB010445 Hs 225948 small inducible cytokine subfamily A (Cy 851 13 13
424012 AW368377 Hs 137569 tumor protein 63 kDa with strong homolog 844 961
430130 AL137311 Hs 234074 Homo sapiens mRNA, cDNA DKFZp761G02121 ( 8 39 513
442577 AA292998 Hs 163900 ESTs 834 792
437191 NM 006846 Hs 331555 senne protease inhibitor, Kazal type, 5 8 16 1008
420859 AW468397 Hs 100000 S100 calcium-binding protein A8 (calgran 804 7 55
413859 AW992356 Hs 8364 Homo sapiens pymvate dehydrogenase kma 768 781
452240 AI591147 Hs 61232 ESTs 763 939
442757 AI739528 Hs 28345 ESTs 762 731
450680 AF131784 Hs 25318 Homo sapiens clone 25194 mRNA sequence 7 51 6 17
456525 AW468397 Hs 100000 S100 calcium-binding protein A8 (calgran 749 712
407328 AA508857 ESTs, Weakly similar to ALU1.HUMAN ALU S 735 720
414217 AI309298 Hs 279898 Homo sapiens cDNA FLJ23165 fis, clone L 7 16 839
417240 N57568 Hs 48028 EST 7 13 1505
410052 AA525225 Hs 334630 Homo sapiens cDNA FU 14462 fis, clone MA 713 7 28
431842 NM 005764 Hs 271473 epithelial protein up-regulated in carci 706 693
426488 X03350 Hs 4 al∞hol dehydrogenase 1 B (dass I), beta 703 785
439394 AA149250 Hs 56105 ESTs 700 453
422963 M79141 Hs 13234 ESTs 699 530
417515 L24203 Hs 82237 ataxia-telangixtasia group D-assxiated 697 2068
410530 M25809 Hs 64173 ATPase, H transporting, lysosomal (vxuo 696 704
446989 AK001898 Hs 16740 hypothedcal protein FU11036 696 668
427890 AA435761 ESTs 694 668
432374 W68815 Hs 301885 Homo sapiens cDNA FU 11346 fis, clone PL 684 844
429624 AA458648 Hs 99476 ESTs, Weakly simitar to 1313184B alphal 683 637
451029 AA852097 Hs 25829 ras related protein 681 896
408000 L11690 Hs 198689 bullous pemphigoid andgen 1 (230/240kD) 680 768
439496 BE616501 Hs 32343 Homo sapiens, Similar to RIKEN cDNA 1110 677 1406
431713 AK000388 Hs 267997 EHM2 gene 672 7 11
451253 H48299 Hs 26126 claudin 10 6 71 7 17
414987 AA524394 Hs 294022 hypothedcal protein FU 14950 667 11 68
400304 AF005082 Hs 113261 Homo sapiens skm-spxific protein (xp33 664 790
408063 BE086548 Hs 42346 calcineunn-bindmg protein calsarcιn-1 660 729
424364 AW383226 Hs 163834 ESTs, Weakly similar to G01763 atrophin- 6 58 678
421773 W69233 Hs 112457 ESTs 6 55 17 59
425280 U31519 Hs 1872 phosphoendpyruvate carboxykinase 1 (sol 655 679
411388 X72925 Hs 69752 desmxollm 1 655 897
401785 NMJJ02275* Homo sapiens keradn 15 (KRT1 651 994
406867 AA157857 Hs 182265 keradn 19 650 623
429504 X99133 Hs 204238 lipxalin 2 (oncogene 24p3) (NGAL) 6 43 6 79
426106 AI678765 Hs 21812 ESTs 641 769
413172 M38180 Hs 38586 hydroxy-delta-5steroιd dehydrogenase, 3 6 39 709
407395 AF005082 gb Homo sapiens skin-spxific protein (x 639 7 71
422166 W72424 Hs 112405 S100 calcium-binding protein A9 (calgran 636 923
437176 AW176909 Hs 42346 calcmeuπn-binding protein calsarcιn-1 630 545
440383 AA884208 Hs 30484 ESTs 6 26 625
419329 AY007220 Hs 288998 S100-type calcium binding protein A14 6 22 10 13
418686 Z36830 Hs 87268 annexin A8 6 19 6 14
440116 AI798851 hemoglobin, gamma G 6 18 428
424049 AB014524 Hs 138380 KIAA0624 protein 6 18 691
417366 BE185289 Hs 1076 small prolme-πch protein 1B (cornifiπ) 6 17 742
432543 AA552690 Hs 152423 Homo sapiens cDNA FLJ21274 fis, clone C 6 16 686
414449 AA557660 Hs 76152 dxoπn 6 15 393
441188 AW292830 Hs 255609 ESTs 612 668
424008 R02740 Hs 137555 putative chemokine rxeptor, GTP-binding 6 12 533
431319 AA873350 Hs 302232 ESTs 6 11 684
444105 AW189097 ESTs 597 620
428358 AA993222 Hs 101915 Stargardt disease 3 (autosomal dominant) 594 515
407788 BE514982 Hs 38991 S100 calcium-binding protein A2 5 71 583
439706 AW872527 Hs 59761 ESTs, Weakly similar to DAP1_HUMAN DEATH 569 449
428666 AL080190 Hs 189242 Homo sapiens mRNA, cDNA DKFZp434A202 (fr 565 516
410541 AA065003 Hs 64179 syntenιπ-2 protein 562 584
431926 AW972724 gb EST384816 MAGE resequences, MAGL Homo 561 575
430332 R51790 Hs 239483 Human clone 23933 mRNA sequence 560 5 76
444946 AW139205 Hs 156457 hypothedcal protein FU 22408 553 925
430714 AA484757 Hs 287601 Homo sapiens cDNA FU 13830 fis, clone TH 548 538
435538 AB011540 Hs 4930 low density lipoprotein rxeptor-related 546 3 19
414407 AA147026 Hs 76704 ESTs 543 5 29
417035 AA192455 Hs 22968 Homo sapiens clone IMAGE 451939, mRNA se 540 540
442315 AA173992 Hs 7956 ESTs, Moderately similar to ZN91. HUMAN Z 540 387
416931 D45371 Hs 80485 adipose most abundant gene transcπpt 1 539 912
431048 R50253 Hs 249129 cell death-inducing DFFA-like effector a 539 606
436090 AI640635 Hs 332879 EST 537 5 33
411274 NM 002776 Hs 69423 kallikrein 10 537 597
418394 AF132818 Hs 84728 Kruppel-like fxtor 5 (mtesdnal) 536 9 35
406706 X03740 Hs 231581 myosin heavy polypepdde 1, skeletal mu 534 408
430171 AF086289 Hs 234766 skm-spxific protein 532 1040
452747 BE153855 Hs 61460 Ig superfamily receptor LNIR 531 601
426451 AI908165 Hs 169946 GATA-bindmg protein 3 (T-cell rxeptor 5 31 381
414602 AW630088 Hs 76550 Homo sapiens mRNA, cDNA DKFZp564B1264 (f 526 592
424399 AI905687 AI905687 IL-BT095-190199-019 BT095 Homo 5 25 1694
430071 AA355986 Hs 232068 transcnpdon fxtor 8 (represses inter! 520 501
431416 AA532718 Hs 178604 ESTs 5 18 538 420039 NM 004605 Hs 94581 sulfotransferase family, cytosolic, 2B, 5 17 572
446082 AI274139 Hs 156452 ESTs 516 514
430699 AW969847 Hs 292718 ESTs, Weakly simila to RET2 HUMAN RETIN 5 14 497
434625 W01370 Hs 46824 ESTs 512 618
426101 AL049987 Homo sapiens mRN A, cDNA DKFZp564F 112 (fr 5 11 379
419648 T73661 Hs 91877 thyroid hormone responsive SPOT14 (rat) 508 1364
438962 BE046594 gb hπ41d 1 x1 NCI_CGAP_ROF2 Homo sapiens 508 409
419912 AF249745 Hs 6066 Rho guanine nudeodde exchange fxtor ( 508 4 77
420583 H77859 Hs 65450 redculon 4 506 556
432125 AW972667 Hs 183006 Homo sapiens cDNA FLJ 12300 fis, clone MA 505 632
445263 H57646 Hs 42586 KIAA1560 protein 503 522
407839 AA045144 Hs 161566 ESTs 503 527
434293 NM 004445 Hs 3796 EphB6 503 491
427850 AA416756 Hs 161051 ESTs, Moderately simila to ALU6_HUMAN A 499 1604
414657 AA424074 Hs 76780 protein phosphatase 1, regulatory (mhib 494 814
445493 AI915771 metallothionein 1E (funcdonal) 493 433
429365 AA451798 Hs 99249 ESTs 490 5 19
412633 AF001691 Hs 74304 penplakm 490 11 71
448490 AI523897 Hs 271692 ESTs, Weakly simila to I38022 hypothed 485 488
408491 AI088063 Hs 7882 ESTs 480 439
430168 AW968343 Hs 145582 DKFZP434I1735 protein 480 605
407102 AA007629 glycerol-5phosphate dehydrogenase 1 (so 478 723
421998 R74441 poly(A)-bmdmg protein, nuclear 1 477 478
422633 X56832 Hs 118804 enolase 3, (beta musde) 472 624
444930 BE185536 Hs 301183 molxule possessing ankynn repeats iπdu 471 372
439652 W67826 Hs 55412 ESTs, Weakly simila to K1CJ_HUMAN KERAT 4 70 360
450626 AW190989 Hs 1508 insulin-degrading enzyme 468 514
456898 NM 001928 Hs 155597 D component of complement (adipsin) 468 1583
408239 AA053401 ESTs, Moderately simila to ALU7_HUMAN A 467 6 17
415192 D17793 Hs 78183 aldo-keto reductase family 1, member C3 464 448
443827 AI087867 Hs 134667 ESTs 463 506
431441 U81961 Hs 2794 sodium channel, nonvollage-gated 1 alpha 463 848
408741 M73720 Hs 646 carboxypepddase A3 (mast cell) 463 3 19
427318 AF186081 Hs 175783 zinc transporter 462 3 57
453767 AB011792 Hs 35094 extrxellula matnx protein 2, female o 462 514
424046 AF027866 Hs 138202 senne (or cysteine) proteinase inhibito 461 680
437233 D81448 Hs 339352 Homo sapiens brother of CDO (BOC) mRNA 460 6 19
446525 AW967069 Hs 211556 hypothetical protein MGC5487 4 59 245
402294 Target Exon 457 547
424098 AF077374 Hs 139322 small proline-πch protein 3 457 512
420798 W93774 Hs 99936 keradn 10 (epidermolytic hyperkeratosis 457 476
418021 M15881 Hs 1137 uromodulin (uro ucoid, Tamm-Horsfall gly 454 449
422068 AI807519 Hs 104520 Homo sapiens cDNA FLJ13694 fis, clone PL 454 4 32
414798 AI286323 Hs 97411 hypothedcal protein MGC12335 453 304
410132 NM_003480 Hs 300946 Microfibnl-assxiated glycoproteιn-2 453 291
400109 Eos Control 452 394
407242 M18728 gb Human nonspxific crossrexdng aπdg 451 407
431901 AW295050 Hs 272023 transforming xidic coiled-coil ∞ntan 450 4 16
435992 AI033259 Hs 118317 Homo sapiens CDNA FU12088 fis clone HE 450 4 77
447365 BE383676 Hs 334 Rho guanine nucleotide exchange fxtor ( 450 399
449785 AI225235 Hs 288300 hypothedcal protein FLJ23231 449 402
424620 AA101043 Hs 151254 kallikrein 7 (chymotrypdc, stratum com 447 543
432559 AW452948 Hs 257631 ESTs 447 3 10
459290 NM 001546 Hs 34853 inhibitor of DNA binding 4 dominant πeg 445 317
422313 AF045941 Hs 115166 sciellin 445 507
416305 AU076628 Hs 79187 coxsxkie virus and adenovirus rxeptor 444 525
432314 AA533447 Hs 312989 ESTs 444 352
441633 AW958544 Hs 112242 normal mucosa of esophagus spxific 1 443 264
424670 W61215 Hs 116651 epithelial V-like andgen 1 442 427
414489 AI620677 Hs 73105 ESTs 441 377
413040 AA193338 Hs 12321 sodium calcium exchanger 436 458
426974 AB002298 Hs 173035 KIAA0300 protein 435 497
448249 AW855331 Hs 337124 ESTs 435 449
451743 AW074266 Hs 23071 ESTs 434 452
427919 AA173942 Hs 326416 Homo sapiens mRNA, cDNA DKF2p564H1916 (f 433 394
422305 AI928242 Hs 293438 ESTs, Highly similar to AF 198488 1 trans 432 720
408104 AW972927 Hs 293968 ESTs 431 353
447945 AI922838 Hs 9670 ESTs, Weakly simila to ALU 1 HUMAN ALU S 430 372
439349 AI660898 Hs 6834 ESTs 429 4 16
433339 AF019226 Hs 8036 glioblastoma overexpressed 4 29 394
427074 AA527435 Hs 178589 hepatoςellula carcinoma antigen gene 52 428 497
453574 AI767947 Hs 50841 ESTs 425 366
410677 NM_003278 Hs 65424 tetranxtin (plasminogen-bindmg protein 4 25 1764
424833 NM_003894 Hs 153405 penod (Drosophila) homolog 2 422 313
426248 T18988 Hs 293668 ESTs 4 21 409
410480 R97457 Hs 63984 cadheπn 13. H-cadhenn (heart) 419 276
406805 AI686003 Hs 296031 ESTs 19 387
438533 AI440266 Hs 170673 ESTs, Weakly similar to T24832 hypotheti 4 18 593
451831 NM 001674 Hs 60 xdvadng transcnpdon fxtor 3 418 474
431211 M86849 Hs 323733 gapjuncdon protein, beta 2, 26kD (conn 17 283
434936 AI285970 Hs 183817 ESTs 17 4 39
430361 AI033965 Hs 239926 sterol-C4-methyl oxidase-like 4 17 238
448429 D17408 Hs 21223 calponin 1, basic, sm∞th muscle 4 16 5 15 421978 AJ243662 Hs 110196 NICE-1 protein 4 15 807
437135 AL038624 Hs 208752 ESTs, Weakly similar to ALU8 HUMAN ALU S 4 14 492
442554 AW467376 Hs 129640 ESTs 412 400
451814 AA847992 Hs 137003 ESTs 4 11 458
410023 AB017169 Hs 57929 slit (Drosophila) homolog 3 4 10 392
457121 AI743770 Hs 180513 ESTs, Weakly similar to KIAA0822 protein 409 3 19
426539 AB011155 Hs 170290 discs, large (Drosophila) homolog 5 409 369
430191 AI149880 Hs 188809 ESTs 407 449
430433 AA478883 Hs 273766 ESTs 407 374
425992 AA367069 Hs 100636 ESTs 406 437
428931 AA994979 Hs 98967 ATPase, H()-fransportmg, lysosomal, non 405 4 15
452392 L20815 Hs 507 comeodesmosin 404 11 00
402845 ENSP00000246267 KIAA0444 PROTEIN (FRAGME 403 418
439873 8E159253 Hs 300638 ESTs 403 386
432305 M62402 Hs 274313 insulin-like growth fxtor binding prote 402 879
420789 AI670057 Hs 199882 ESTs 402 434
453560 AA348626 Hs 5890 hypothetical protein FU 23306 402 513
428957 NM 003881 Hs 194679 WNT1 inducible signaling pathway protein 401 429
429556 AW139399 Hs 98988 ESTs 401 459
448585 AB020676 Hs 21543 KIAA0869 protein 401 452
403710 C4000160 gι|12735793|ref|XP_011928 11 pr 400 331
423634 AW959908 Hs 1690 hepann-bindmg growth fxtor binding pr 398 661
421485 AA243499 Hs 104800 hypothedcal protein FU10134 398 379
437611 AA897108 gb amOβaOδ s1 Soaes_NFL_T_GBC_S1 Homo s 397 424
426500 NM 014638 Hs 170156 KIAA0450 gene product 396 493
448710 T62926 Hs 304184 ESTs 396 454
408199 AA132637 Hs 15396 Homo sapiens, clone IMAGE 3948909, mRNA, 395 557
428340 AF261088 Hs 154721 acomtase 1, soluble 394 324
410197 NM 005518 Hs 59889 3-hydroxy-5methylglutaryl-Coeπzyme A sy 394 9 16
456972 AI054347 Hs 2017 πbosomal protein L38 393 437
418381 AA682393 Hs 119237 ESTs 393 345
444781 NM 014400 Hs 11950 GPI-anchored metastasis-associated prote 392 1500
456332 AA228357 gb nc39d05 r1 NCI_CGAP_Pr2 Homo sapiens 391 488
445607 AA488107 Hs 30156 ESTs, Weakly similar to unnamed protein 391 319
426411 AK000708 Hs 169764 hypothedcal protein FU20701 390 4 50
446733 AA863360 Hs 26040 ESTs, Weakly similar to fatty xid omega 390 389
442498 U54617 HS 8364 Homo sapiens pyruvate dehydrogenase k a 389 511
452894 AI598065 Hs 61558 ESTs 388 373
430570 A-417881 Hs 292464 ESTs 387 447
439625 AF086453 Hs 58611 ESTs 386 481
418793 AW382987 Hs 88474 prostaglandm-endoperoxide synthase 1 (p 385 301
431247 A 21578 Hs 278489 matπlin 4 385 335
426350 NM.003245 Hs 2022 transglutaminase 3 (E polypepdde prote 385 515
441319 AI354869 Hs 133081 ESTs Weakly similar to T08700 hypotheti 384 503
452877 AI250789 Hs 32478 ESTs 384 326
444252 R21135 Hs 54985 ESTs 383 558
416265 AA177088 Hs 190065 ESTs 382 387
418875 W19971 Hs 233459 ESTs 380 292
440509 BE410132 Hs 134202 ESTs, Weakly similar to T17279 hypotheti 380 436
442503 AF147078 Hs 150853 p53-responsιve gene 5 380 753
427081 AI474533 Hs 170528 ESTs, Moderately similar to ALUC.HUMAN " 377 481
458222 AW139592 hypothetical protein DKFZp434K1421 377 356
445107 AI208121 Hs 147313 ESTs Weakly similar to 138022 hypotheti 377 320
436283 AI480319 Hs 120058 ESTs 376 376
436557 W15573 Hs 5027 ESTs, Weakly simila to A47582 B-cell gr 376 265
448988 Y09763 Hs 22785 gamma-ammobutyπc xid (GABA) A recepto 375 7 59
434206 AW136973 ESTs, Weakly simila to S69890 mitogen i 372 396
424824 AI217440 Hs 143873 ESTs 372 352
457411 AW085961 Hs 130093 iroquois-class homeobox protein IRX2 371 305
452241 AL050204 Hs 28540 Homo sapiens mRNA, cDNA DKFZp586F1223 (f 370 484
421845 AW021631 Hs 16515 ESTs 369 359
413922 AI535895 Hs 221024 ESTs 368 422
422746 NM 004484 Hs 119651 glypican 3 368 429
433934 AW273261 Hs 216292 ESTs 368 439
452547 AA335295 Hs 74120 adipose spxific 2 366 1223
400295 W72838 AI905687 IL-BT095190199-019 BT095 Homo 366 925
419098 AA234041 Hs 87271 ESTs 366 494
417054 AF017060 aldehyde oxidase 1 365 4 51
423974 AL118754 gb DKFZp761P1910 r1 761 (synonym hamy2) 365 432
431362 AI874223 Hs 293560 ESTs 365 3 73
420506 AW977779 Hs 194613 ESTs 365 325
448065 AI459177 Hs 172759 ESTs, Moderately similar to ALU7.HUMAN A 364 462
437457 AA757900 Hs 270823 ESTs Weakly similar to S65657 aTpha-1C- 364 454
451951 AW082870 Hs 210954 ESTs 364 369
436679 AI127483 Hs 120451 ESTs, Weakly similar to unnamed protein 364 3 39
412676 NM_000165 Hs 74471 gap juncdon protein, alpha 1 43kD (con 362 362
412668 AA456195 hypothetical protein FU 14621 362 4 22
413899 AF083892 Hs 75608 dght juncdon protein 2 (zona o∞ludens 362 306
444726 NM 006147 interferon regulatory fxtor 6 359 1065
428722 U76456 Hs 190787 dssue inhibitor of metalloproteinase 4 359 3 31
429973 AI423317 Hs 164680 ESTs 359 371
452413 AW082633 Hs 215030 ESTs 358 466
416157 NM 003243 HS 342874 transforming growth fxtor beta recepto 358 444 430397 AI924533 Hs 105607 bicarbonate transporter related protein 357 374
411939 AI365585 Hs 146246 ESTs 357 1242
450353 AI244661 Hs 103296 ESTs, Weakly similar to S65657 alpha-1C- 357 411
432406 AI340571 Hs 343666 KIAA0969 protein 3 57 284
439609 AW971945 Hs 293236 ESTs 3 56 3 14
435381 AW136397 Hs 175382 ESTs 356 348
410173 AA706017 Hs 119944 ESTs 356 337
414002 NM 006732 Hs 75678 FBJ munπe osteosarcoma viral oncogene h 356 993
413305 NM 000426 Hs 323511 Homo sapiens cDNA FU23176 fis, one L 355 424
434360 AW015415 Hs 127780 ESTs 3 55 477
423973 AF038461 Hs 136574 arxhidonate 12-lιpoxygenase, 12R type 353 565
425681 AB018297 Hs 159183 KIAA07S4 protein 352 479
428382 AF007132 Hs 184019 Homo sapiens clone 23551 mRNA sequence 351 446
451184 T87943 franxπpdon fxtor 7-lιke 2 (T-cell sp 351 363
448496 BE379077 Hs 130849 ESTs, Weakly similar to I38022 hypothed 351 330
425831 U46689 Hs 159608 aldehyde dehydrogenase 3 family, member 348 866
428232 BE272452 Hs 183109 monoamine oxidase A 348 954
425483 AF231022 Hs 158159 FAT tumor suppressor (Drosophila) homolo 348 605
401760 Target Exon 348 786
427899 AA829286 Hs 332053 serum amyloid A1 347 367
451767 AI625014 Hs 187328 ESTs 346 385
452849 AF044924 Hs 30792 hook2 protein 345 566
427408 AA583206 Hs 2156 RAR-related orphan rxeptor A 345 502
447165 AL042400 Hs 75668 Homo sapiens, Similar to RIKEN cDNA 1700 345 361
422083 NM 001141 Hs 111256 arxhidonate 15-dpoxygenase, sxoπd typ 345 771
420876 AA918425 Hs 177744 ESTs 344 846
421114 AW975051 Hs 293156 ESTs, Weakly similar to I78885 senne/th 344 447
426233 AA372796 Hs 269339 ESTs, Weakly similar to AF161356 1 HSPC0 344 396
428221 U96781 Hs 183075 ATPase, Ca transporting cardix muscle, 342 432
403593 Target Exon 342 635
423467 AK000214 Hs 129014 hypothedcal protein FU20207 342 334
447731 AA373527 Hs 19385 CGI 58 protein 341 244
456327 H68741 Hs 38774 ESTs 340 346
413880 AI660842 Hs 110915 interieukin 22 rxeptor 337 361
429501 AI700588 Hs 293388 ESTs, Weakly simila to A34612 zinc fing 337 344
437575 AW954355 Hs 36529 hypothedcal protein MGC11242 336 487
420231 R06866 Hs 19813 ESTs 336 860
424010 AL080188 Hs 137556 Homo sapiens mRNA, cDNA DKFZp434A132 (fr 336 620
426789 F06596 Hs 23837 Homo sapiens cDNA FLJ 11812 fis, clone HE 334 340
434274 AA628539 Hs 116252 ESTs, Moderately similar to ALU1_HUMAN A 334 335
420693 NM 001972 Hs 99863 elastase 2, neutrophil 334 406
418318 U47732 Hs 84072 transmembrane 4 superfamily member 3 333 436
413163 Y00815 Hs 75216 protein tyrosine phosphatase, rxeptor t 332 9 7
428496 AA769986 Hs 185802 ESTs 332 388
416349 X69089 Hs 79227 myomesm (M protein) 2 (165kD) 331 401
409095 AW337272 Hs 293656 ESTs, Moderately similar to S72481 proba 3 31 331
443072 AI937532 gb wp78d02 x1 NCI_CGAP_Brn25 Homo sapien 331 440
437596 AA761490 ESTs, Moderately similar to S65657 alpha 330 531
444094 AI695764 Hs 202394 ESTs 329 347
437150 R51407 Hs 77910 5hydroxy-5methylglutaryl-Coenzyme A sy 329 376
407334 AA494411 Hs 296031 ESTs 3 28 430
423017 AW178761 Hs 227948 senne (or cysteine) proteinase inhibito 328 378
447875 R22029 Hs 13905 ESTs 328 344
418969 W33191 Hs 28907 hypothetical protein FU20258 327 371
411962 AA099050 gb zk85d12 r1 Soares_pregπanLuterus_NbH 327 4 28
424395 AA165082 Hs 146388 microtubule-assxiated protein 7 3 27 382
400494 ENSP00000238970* CIG30 (Fragment) 327 260
430418 R98852 Hs 36029 heart and neural crest denvadves expre 326 6 19
409231 AA446644 Hs 692 GA733-2 antigen, epithelial gly∞protem 326 424
434952 T10269 Hs 4285 Homo sapiens cDNA FU22505 fis, clone H 326 5 17
445234 AW137636 Hs 146059 ESTs 3 25 559
426150 NM.003658 Hs 167218 BarH-like homxbox 2 325 521
400076 Eos Control 325 360
421462 AF016495 Hs 104624 aquapoπn 9 325 393
420677 AW086215 Hs 246096 ESTs 325 353
424125 M31669 Hs 1735 inhibin, beta B (xdvm AB beta polypep 3 24 388
443672 AA323362 Hs 9667 butyrobetaπe (gamma), 2-oxoglutarate di 324 564
420682 AI380552 Hs 88602 ESTs 3 24 4 13
423725 AJ403108 Hs 132127 hypothetical protein LOC57822 3 23 4 90
431157 AI823969 Hs 132678 ESTs 323 397
440469 AA886068 gb ny40e07 s1 NCI CGAP Pr12 Homo sapiens 3 23 339
449961 AW265634 Hs 133100 ESTs 321 536
407948 AW085161 Hs 56279 ICEBERG C3spase-1 inhibitor 3 21 461
400835 chromosome 2 open reading frame 2 321 362
413329 AI056885 Hs 133539 ESTs 321 343
414825 X06370 Hs 77432 epidermal growth fxtor receptor (avian 321 372
450860 AA021007 integnn beta 8 320 589
444816 Z48633 Hs 283742 H sapiens mRNA for retrotransposon 3 19 684
453855 AA039576 Hs 37858 ESTs, Weakly similar to ALUBJHUMAN "« 3 19 359
432278 AL137506 Hs 274256 hypothetical protein FU23563 3 19 3 51
420074 AA253425 Hs 190074 ESTs 318 550
418481 M81945 CD34 antigen 318 365
408522 AI541214 Hs 46320 Small proline-πch protein SPRK (human 3 18 743 435337 AI078307 Hs 134317 ESTs Weakly simila to PC4259 ferntm 3 17 351
445502 AW379160 Hs 12813 DKFZP434J214 protein 3 17 362
412477 AA150864 microsom.il glutathione S-transferase 1 317 539
421757 Z20897 Hs 296259 paraoxonase 3 316 360
413835 AI272727 Hs 249163 fatty xid hydroxylase 3 16 556
420309 AW043637 Hs 21766 ESTs, Weakly similar to ALU5.HUMAN ALU S 3 15 1 99
444895 AI674383 Hs 22891 solute earner family 7 (cationic am o 3 15 445
414869 AA157291 Hs 21479 ubinuclein 1 313 440
412947 AA122277 gb zk97e09 s1 Soares_pregnant_utenιs_NbH 3 13 330
443265 AI916207 Hs 9167 SH3 domain binding glutamic xid-πch pr 3 12 462
421335 X99977 Hs 103505 ARS component B 311 11 54
401905 ENSP0O000252232* Sterol regulatory eleme 3 10 285
443514 BE464288 Hs 141937 ESTs 309 366
418817 AA913229 Hs 19339 ESTs 308 388
434727 H43374 Hs 7890 Homo sapiens mRNA for KIAA1671 protein, 308 418
435858 AF254260 Hs 283009 tuftel 1 308 396
430285 AI917602 Hs 106440 ESTs 307 330
448106 AI800470 Hs 171941 ESTs 307 519
432908 AI861896 ESTs 307 385
450086 AW016343 Hs 233301 ESTs 307 338
451529 AI917901 Hs 208641 ESTs 307 329
418443 NM 005239 Hs 85146 v-ets avian erythroblastosis virus E26 o 306 412
426848 H72531 Hs 36190 ESTs 305 434
429506 D49835 Hs 171942 ras responsive element binding protein 1 305 397
425955 T96509 Hs 248549 ESTs, Moderately simila to S65657 alpha 305 329
413822 R08950 Hs 272044 ESTs, Weakly similar to ALU1_HUMAN ALU S 305 389
434230 AA551569 hypothedcal protein PR02822 304 363
453655 AW960427 Hs 342874 transfoiming growth fxtor, beta rxepto 304 809
415696 AI821552 Hs 188682 ESTs 303 343
449618 AI076459 Hs 15978 KIAA1272 protein 301 329
414665 AA160873 serum amyloid A 1 301 922
446682 AW205632 Hs 211198 ESTs 300 330
443801 AW206942 Hs 253594 intron of tnchorhinophalangeal syndro 299 374
412446 AI768015 ESTs 299 447
449271 AW338067 Hs 7869 Homo sapiens cDNA FU 11946 fis, clone HE 299 435
435702 AI033647 Hs 121001 Homo sapiens clone IMAGE 3460280, mRNA 298 349
403180 Target Exon 298 392
434442 AA737415 ESTs 298 361
439593 BE073597 Hs 124863 ESTs 298 386
410453 AW749036 gb RC2-BT0315241199-011-f10 BT0318 Homo 298 349
414766 AW293452 Hs 16228 ESTs 297 363
432566 AW439330 Hs 256889 ESTs, Weakly simila to 2109260A B cell 297 399
451541 BE279383 Hs 26557 plakophilin 3 297 690
452195 AA994712 Hs 116878 ESTs 297 330
401747 Homo sapiens keradn 17 (KRT17) 297 410
431316 AA502663 Hs 145037 ESTs 296 305
445437 AI224165 Hs 148725 ESTs 295 712
421690 AW162667 Hs 106857 calbmdin 2 (29kD calrednin) 295 568
456371 S76825 Hs 89695 insulin rxeptor 294 459
449543 AF070632 Hs 23729 Homo sapiens clone 24405 mRNA sequence 294 412
436664 AW197887 Hs 253353 ESTs 293 357
406962 M13485 gb Human metallothionem l-B gene exon 293 266
422158 L10343 Hs 112341 protease inhibitor 3 skm-denved (SKAL 292 748
428769 AW207175 Hs 106771 ESTs 292 328
414629 AA345824 Hs 76688 carboxylesterase 1 (monxyte/mxrophage 292 348
444204 AI129194 Hs 143040 ESTs 292 392
421407 T82331 Hs 182278 ESTs Weakly similar to CGHU6C collagen 291 655
453180 N46243 Hs 110373 ESTs, Highly similar to T42626 sxreted 290 392
429538 BE182592 Hs 139322 small proline-nch protein 2A 288 475
452554 AW452434 Hs 58006 ESTs, Weakly simila to ALU5_HUMAN ALU S 288 674
417184 N52510 Hs 268597 Homo sapiens cDNA FU21498 fis, clone C 287 397
412093 BE242691 Hs 14947 ESTs 286 348
424135 AW994455 Hs 140978 Homo sapiens mRNA, cDNA DKFZp762H106 (fr 286 332
437167 AL050184 Hs 21610 OKFZP434B203 protein 286 387
454065 BE394588 gb 601311808F1 NIH_MGC_44 Homo sapiens c 2 86 343
420230 AL034344 Hs 284186 foiWiead box C1 285 367
403108 ENSP00000241415* Hypothedcal 677 kDa p 285 262
434433 AW629759 gb hh70e05 y1 NCI_CGAP_GU1 Homo sapiens 284 335
420544 AA677577 Hs 98732 Homo sapiens Chromosome 16 BAC done CIT 283 266
429429 AA829725 Hs 334437 hypothedcal protein MGC4248 283 3 59
451721 NM 006946 Hs 26915 spxtπn, beta, non-erythrocydc 2 283 336
424982 U94777 phosphoiγlase, glycogen muscle (McArdle 2 83 450
429259 AA420450 Hs 292911 Plakophilin 281 481
423523 AW299828 Hs 193580 ESTs 280 708
433637 AW02421 Hs 102307 ESTs 280 339
452089 T97294 Hs 271492 ESTs Weakly similar to PC4211 hepatocel 280 362
441187 AW195237 Hs 7734 hypothedcal protein FU22174 2 80 352
421965 AA301100 Hs 346482 gb EST14128 Tesds tumor Homo sapiens cD 279 349
432098 AF252297 Hs 91546 cytxhrome P450 rednoid metabolizing pr 279 231
429128 AA446869 Hs 119316 ESTs 278 4 17
438913 AI380429 Hs 172445 ESTs 277 365
445029 AF196481 midline 2 276 379
419923 AW081455 Hs 120219 ESTs 276 300 416508 R39769 Hs 56406 ESTs, Moderately simila to ALU8 HUMAN A 2 76 359
412507 L36645 Hs 73964 EphA4 276 390
446339 AL046962 Hs 14845 forkhead box 03A 275 350
433710 AI341867 Hs 188920 ESTs 275 333
432375 BE536069 Hs 2962 S100 calcium-binding protein P 274 577
409213 U61412 Hs 51133 PTK6 protein tyrosine kinase 6 274 376
426653 AA530892 Hs 171695 dual spxificity phosphatase 1 274 8 19
408839 AW277084 gb xp61h09 x1 NCI_CGAP_Ov39 Homo sapiens 273 393
433091 Y12642 Hs 3185 tymphxyte andgen 6 complex, Ixus D 273 11 6
444026 AA205759 Hs 10119 hypothedcal protein FU 14957 273 617
433713 AW976511 Hs 112592 ESTs 272 342
453317 NM 002277 Hs 41696 keradn, hair, xιdιc,1 272 476
408493 BE206854 Hs 46039 phosphoglycerate mutase 2 (muscle) 272 374
432947 AA570710 Hs 270998 ESTs, Weakly simila to I38022 hypothed 272 344
421428 U26726 Hs 1376 hydroxysteroid (11-beta) dehydrogenase 2 272 495
423217 NM 000094 Hs 1640 collagen, type VII, alpha 1 (epidermolys 272 429
435016 AI284219 Hs 130749 ESTs, Weakly similar to 138022 hypothed 271 445
449667 AB023227 Hs 23860 KIAA1010 protein 271 372
407112 AA070801 Hs 51615 ESTs, Weakly similar to ALU7_HUMAN ALU S 270 382
433848 AF095719 Hs 93764 carboxypepddase A4 270 276
430152 AB001325 Hs 234642 aquapoπn 3 269 426
456063 NM 006744 Hs 76461 rednol-bmdmg protein 4, interstitial 269 672
424471 AA341329 Hs 311524 ESTs 268 457
453201 AI432195 Hs 135098 ESTs 268 369
450912 AW939251 Hs 25647 v-fbs FBJ muπne osteosarcoma viral on∞ 268 425
404996 Target Exon 267 428
409453 AI885516 Hs 95612 ESTs 265 651
430937 X53463 Hs 2704 glutathione peroxidase 2 (gasfrointesdn 265 378
452887 AI702223 Hs 107253 hypothedcal protein DKFZp761F241 264 638
444169 AV648170 Hs 58756 ESTs 264 340
428500 AI815395 Hs 184641 fatty xid desaturase 2 264 3 7
408395 BE072425 Hs 44579 hypothedcal protein FU20199 264 401
432093 H28383 gb yl52c03 r1 Soares breast 3NbHBst Homo 263 408
451621 AI879148 Hs 26770 fatty xid binding protein 7, brain 262 251
447335 BE617695 Hs 286192 hypothedcal protein FU20940 261 362
429343 AK000785 Hs 199480 Homo sapiens, Simila to epsin 3 ctone 261 368
431166 AW971186 Hs 293839 ESTs 261 333
440659 AF134160 Hs 7327 claudin 1 261 353
413542 BE295928 Hs 75424 inhibitor of DNA binding 1 , dominant neg 261 448
413956 AI821351 Hs 193133 ESTs, Weakly similar to ALU7_HUMAN ALU S 260 351
407299 AA460205 Hs 289770 ESTs, Weakly similar to I38022 hypothed 259 382
449539 W80363 Hs 58446 ESTs 258 405
413884 AI668892 Hs 239758 hypothetical protein FU12389 similar to 258 4 19
445620 AI245225 Hs 17441 ESTs 257 344
433688 AA628467 Hs 112572 Homo sapiens CDNA FLJ14130 fis done MA 2 56 357
424834 AK001432 Hs 153408 Homo sapiens cDNA FLJ 10570 fis, clone NT 256 347
407083 Z48511 H sapiens XG mRNA (clone PEP11) 255 361
406790 AA293303 nbosomal protein L27a 254 436
450472 AI190071 Hs 55278 ESTs 254 430
410310 J02931 Hs 62192 coagulation fxtor III (thromboplastm 254 382
454034 NM_000691 Hs 575 aldehyde dehydrogenase 3 family, member 254 344
430821 AA487264 Hs 154974 Homo sapiens mRNA cDNA DKFZp667N064 (fr 254 455
402575 Rho GTPase xdvating protein 1 253 547
429554 NM 012275 Hs 207224 interieukin 1 , delta 253 240
431631 AA548906 Hs 122244 ESTs 252 379
408806 AW847814 Hs 75608 Homo sapiens cDNA FU21532 fis clone C 252 451
420235 AA256756 Hs 31178 ESTs 251 4 21
436314 AI983409 ESTs 251 311
432906 BE265489 Hs 3123 lethal giant larvae (Drosophila) homolog 250 562
429547 AW009166 Hs 99376 FGENESH predicted novel sxreted protein 249 260
410532 T53088 Hs 155376 hemoglobin, beta 249 473
413475 AW021488 Hs 26981 ESTs 249 390
429325 AW088739 Hs 243770 ESTs 248 371
424604 AW865388 Hs 151076 KIAA1243 protein 248 416
414320 U13616 Hs 75893 ankyππ 3, node of Ranvier (ankyπn G) 248 380
423929 M69136 Hs 135626 chymase 1 , mast cell 248 347
410275 U85658 Hs 61796 transcnpdon fxtor AP-2 gamma (xdvat 247 209
444935 AA262449 Hs 223569 ESTs 247 596
445389 NM 016831 Hs 12592 peπod (Drosophila) homolog 3 247 341
437897 AA770561 Hs 146170 hypothetical protem FLJ 22969 247 680
446292 AF081497 Hs 279682 Rh type C glycoprotein 246 7 37
409178 BE393948 Hs 50915 kallikrein 5 246 559
452865 AI924046 Hs 119567 ESTs, Weakly similar to A47582 B-cell gr 246 603
447179 AW015633 Hs 157299 ESTs 246 323
414459 Y11525 Hs 76171 CCAAT/eπhancer binding protein (C EBP), 246 395
428188 M98447 Hs 22 transglutaminase 1 (K pdypepdde epider 245 394
428593 AW207440 Hs 185973 degenerative spermatxyte (homolog Droso 244 2 17
436009 H57130 Hs 120925 ESTs 244 294
412810 M21574 Hs 74615 platelet-denved growth fxtor rxeptor, 243 361
416749 AW068550 comp Hs 79732 fibulin 1 243 446
444672 Z95636 Hs 11669 laminin, alpha 5 242 639
433143 BE552155 Hs 294035 ESTs, Weakly similar to ALU5_HUMAN ALU S 242 345
406997 U07807 metallothionem IV 242 392 423184 NM -04428 Hs 1624 ephnn-A1 241 434
421321 NM 005309 Hs 103502 glutamic-pyruvate transammase (alanine 241 508
456826 AI871742 Hs 302428 w gless-type MMTV integration site fami 241 392
428897 AJ245719 Hs 194385 hypothetical protein FLJ20234 241 518
400232 NM_001895* Homo sapiens casein kinase 2, 241 382
421481 AW391972 Hs 104696 KIAA1324 protein 240 403
442083 R50192 Hs 165062 ESTs 239 421
422287 F16365 Hs 114346 cytxhrome c oxidase subunit Vila polype 2 39 860
418004 U37519 Hs 87539 aldehyde dehydrogenase 3 family, member 239 257
457008 AA410446 Hs 112011 ESTs, Weakly simila to unknown (H sapie 239 385
418355 L42563 Hs 1165 ATPase, rø transporting, nongastπc, alp 238 384
431179 AI338644 Hs 195432 aldehyde dehydrogenase 2 family (mitxho 237 789
432563 NM.013261 Hs 198468 peroxisome proliferadve xdvated rxep 237 377
402338 Target Exon 237 346
443725 AW245680 Hs 9701 growth arrest and DNA-damage-inducible, 237 457
436723 AW975895 Hs 307486 ESTs 237 639
452669 AA216363 Hs 262958 hypothedcal protein DKFZp434B044 237 392
409212 AI082423 Hs 141892 ESTs 236 379
451323 AI903313 Hs 34579 ESTs, Moderately similar to ALU6_HUMAN A 235 329
400307 AF005081 Homo sapiens skm-spxific protein (xp32 235 996
421993 R22497 Hs 110571 growth arrest and DNA-damage-inducible, 2 35 516
451092 AI207256 Hs 13766 Homo sapiens mRNA for FU00074 protein, 234 524
446948 BE409053 Hs 299629 peroxisomal long-chain xyl-coA thioeste 234 377
424425 AB031480 Hs 146824 SPR1 protein 234 443
426050 AF017307 Hs 166096 E74-lιke fxtor 3 (ets domain transcπpt 234 564
425180 U00115 Hs 155024 B-cell CLUIymphoma 6 (zinc finger prote 233 351
422106 D84239 Hs 111732 Fc fragment of IgG binding protem 233 695
423503 M92843 Hs 343586 zinc finger protein homologous to Zfp-36 2 33 557
453999 BE328153 Hs 240087 ESTs 232 340
419358 T78763 Hs 90063 neurxalcm delta 232 672
430468 NMJ04673 Hs 241519 angiopoiedn-like 1 2 32 390
456876 AL044870 Hs 208780 ESTs, Weakly similar to T29647 hypothed 232 327
454947 AW846590 gb QVO-CT0180-011099-025d07 CT0180 Homo 232 443
429211 AF052693 Hs 198249 gap junction protein, beta 5 (connexin 3 2 31 722
438282 BE268288 Hs 195432 aldehyde dehydrogenase 2 family (mitxho 231 334
420202 AL036557 Hs 95910 putative lymphxyte G0/G1 switch gene 231 847
419245 AI732742 Hs 87440 ESTs 231 339
444920 AW450967 Hs 235240 ESTs 230 330
417314 N68168 gb za11c01 si Soaes fetal liver spleen 230 312
409586 AL050214 Hs 55044 DKFZP586H2123 protein 230 352
433662 W07162 Hs 150826 RAB25 RAB25, member RAS on∞gene family 229 6 11
451176 AA046457 Hs 60677 ESTs 229 659
410531 AW752953 gb QVO-CT0224-261099-035g02 CT0224 Homo 229 329
425982 R05327 Hs 189726 ESTs 229 337
435684 NM.001290 Hs 4980 LIM domain binding 2 229 454
453003 AA808466 Hs 103395 hypothedcal protein FLJ14146 2 28 370
434411 AA632649 Hs 201372 ESTs 228 440
407394 AF0O5081 gb Homo sapiens skm-spxific protein (x 2 28 1057
411579 AC005258 Hs 70830 U6 snRNA assxiated Sm-like protein LSm7 2 28 406
401205 Target Exon 2 27 2 71
443102 AI247472 Hs 132965 ESTs 2 27 566
422109 S73265 Hs 1473 gastπn-releasing pepdde 226 394
434987 AW975114 ESTs 2 26 372
415477 NM.002228 Hs 78465 v-jun avian sarcoma virus 17 oncogene ho 2 26 342
423515 AA327017 Hs 176594 ESTs 2 25 621
434903 AF161369 Hs 187763 Homo sapiens HSPC106 mRNA, partial eds 225 362
443049 AI028613 Hs 132343 ESTs 2 25 313
444637 T19101 Hs 11494 fibulin 5 224 643
410026 AI912061 Hs 55016 hypothedcal protein FU21935 223 331
418629 BE247550 Hs 86859 growth fxtor receptor-bound protein 7 223 417
429587 AA283969 Hs 334706 Homo sapιens cDNA FU11801 fis clone HE 223 379
431986 AA536130 Hs 149018 Novel human gene mapping to chomosome 20 222 354
409571 AA504249 Hs 187585 ESTs 2 22 387
446051 BE048061 Hs 37054 ephnn-A3 222 457
422418 AK0O1383 Hs 116385 hypothetical protein FLJ 10521 221 425
453023 AW028733 Hs 31439 senne protease inhibitor, Kunitz type. 221 507
435748 AA699756 Hs 117335 ESTs 220 335
420105 AW015571 Hs 32244 ESTs, Weakly similar to FMOD_HUMAN FIBRO 2 19 655
444922 AI921750 Hs 144871 Homo sapiens cDNA FU13752 fis, clone PL 219 351
433052 AW971983 Hs 293003 ESTs, Weakly similar to PC4259 ferndn 2 19 332
430310 U60115 Hs 239069 four and a half LIM domains 1 219 383
447205 BE617015 Hs 11006 ESTs, Moderately similar to T17372 plasm 2 19 1565
449967 R40978 Hs 271498 ESTs, Moderately similar to ALU1.HUMAN A 218 354
452689 F33868 Hs 284176 transfemn 2 18 330
417061 AI675944 Hs 188691 Homo sapiens cDNA FU12033 fis, clone HE 2 18 377
432647 AI807481 Hs 278581 fibroblast growth fxtor rxeptor 2 (bx 2 18 564
401192 Target Exon 217 333
421752 AK001521 Hs 107882 hypothetical protein FU10659 2 16 344
456646 AJ243662 Hs 110196 NICE-1 protein 2 16 239
421263 AB020638 Hs 103000 KIAA0831 protein 2 16 337
445656 W22050 Hs 21299 ESTs Weakly similar to AF151840 1 CGI-8 2 16 5 17
450624 AL043983 Hs 125063 Homo sapiens cDNA FU 13825 fis, clone TH 2 15 387
429350 AI754634 Hs 131987 ESTs 2 15 390 448144 AW169230 ESTs, Moderately similar to PC4259 fern 214 328
429002 AW248439 Hs 2340 juncdon plakoglob 2 14 505
429297 X82494 Hs 198862 fibulin 2 2 14 4 32
452093 AA447453 Hs 27860 Homo sapiens mRNA, cDNA DKFZp586M0723 (f 2 14 399
428848 NM 000230 Hs 194236 lepdn (murine obesity homolog) 2 14 339
407584 W25945 Hs 8173 hypothedcal protein FLJ10803 2 14 3 38
453155 AF052126 Hs 552 steroιd-5alpha-reduct3se, alpha polypep 2 14 251
453283 AA694386 Hs 290914 ESTs 213 3 28
456906 AF117646 Hs 156637 Cas-Br-M (munne) xtropic retroviral tr 213 3 76
414815 AW292140 Hs 130286 ESTs 213 4 16
417155 T75125 Hs 299148 hypothedcal protein FU21801 2 13 357
416673 T77052 Hs 14039 ESTs 213 343
452208 AA024792 Hs 31895 hypothedcal protein MGC4093 212 5 67
413966 AA133935 Hs 173704 ESTs, Moderately simila to A53959 throm 2 12 4 76
430967 H16791 Hs 100895 ESTs 212 264
429015 8E168484 Hs 194737 KIAA0453 protein 212 330
439518 W76326 gb zd60d04 r1 Soares fetal heart NbHH19W 2 11 259
426468 AA379306 Hs 117558 ESTs 2 10 356
407555 Z48511 gb H sapiens XG mRNA (clone PEP11) 210 366
418226 AA424202 Hs 83834 cytxhrome b-5 210 514
423441 R68649 Hs 278359 absent in melanoma 1 like 210 364
436961 AW375974 Hs 156704 ESTs 210 3 21
432633 AI796390 Hs 210667 ESTs 210 258
426102 AF200496 Hs 166371 interieukin 1, zeta 209 377
445467 AI239832 Hs 15617 ESTs, Weakly similar to ALU4_HUMAN ALU S 209 385
437124 AA554458 KIAA0666 protein 209 3 35
407757 BE048414 Hs 165215 hypothedcal protein MGC5395 208 4 41
407815 AW373860 Hs 183860 hypothedcal protein FU20277 208 501
443906 AA348031 Hs 7913 ESTs 208 3 0
423887 AL080207 Hs 134585 DKFZP434G232 protein 208 3 92
406400 kallikrein 8 (neuropsin/ovasin) (KLK8) 208 4 19
437704 AA766142 Hs 131810 ESTs, Moderately similar to ALU1 HUMAN A 207 3 30
412533 AA679863 Hs 69606 ESTs 207 339
426310 NM 000909 Hs 169266 neuropepdde Y rxeptor Y1 206 3 55
411821 BE299339 Hs 72249 three-PDZ ∞ntamiπg protein simila to 206 498
442599 AF078037 Hs 324051 RelA-assxiated inhibitor 206 7 23
432212 AW137742 ESTs 204 3 52
453469 AB014533 Hs 33010 KIAA0633 protein 204 401
443652 AI080692 Hs 134229 ESTs, Weakly similar to 154401 hyperteπs 204 336
452955 AW390282 Hs 31130 transmembrane 7 superfamily member 2 203 364
424464 R68537 Hs 17962 ESTs 203 4 36
408702 AW959893 Hs 27099 hypothedcal protein FLJ23293 similar to 203 331
439908 AI168031 Hs 155507 ESTs 203 383
412825 AW167439 Hs 190651 Homo sapiens cDNA FLJ 13625 fis clone PL 202 556
406784 AI144297 Hs 169401 apolipoprotein £ 202 340
427309 NM 005714 Hs 175218 potassium channel subfamily K, member 7 202 458
453195 BE241876 Hs 32352 hypothedcal protein DKFZp434K1210 202 357
404246 Target Exon 201 730
443679 AK001810 Hs 9670 hypothetical protein FLJ10948 201 581
410669 AW805749 superoxide dismutase 2, mitxhondnal 201 305
446193 AI279390 Hs 144658 ESTs, Weakly similar to T17257 hypotheti 201 2 32
449228 AJ403107 Hs 148590 protein related with psoπasis 200 5 10
434346 AA630445 ESTs 200 3 51
456098 AW747800 Hs 55016 hypothetical protein FU21935 200 496
452467 AW5O0815 ESTs 200 466
442866 AI743317 Hs 283622 ESTs, Weakly simila to ALU5_HUMAN ALU S 1 98 372
434699 AA643687 Hs 149425 Homo sapiens cDNA FU 11980 fis, clone HE 1 98 311
417553 L09190 tπchohyaliπ 1 98 209
449142 R15913 Hs 194987 ESTs 1 98 350
407597 AA043925 Hs 339352 Homo sapiens brother of CDO (BOC) mRNA, 1 98 6 25
429299 AI620463 Hs 347408 hypothedcal protein MGC13102 1 97 377
423031 AI278995 ESTS 1 97 362
433495 AW373784 Hs 71 alpha-2-gly∞proteιn 1 , zinc 1 96 4 57
430420 AW140 27 Hs 26373 Homo sapiens cDNA FLJ23449 fis, clone H 1 96 609
420139 NM 005357 Hs 95351 lipaεe, hormone sensidve 1 95 5 77
418462 BE001596 Hs 85266 integnn beta 4 1 95 609
447261 NM_006691 Hs 17917 extrxellular link doman-contanmg 1 1 95 333
437220 AL117542 Hs 334305 GS1999full 1 94 345
407601 AC002300 Hs 37129 sodium channel, nonvoltage-gated 1 , beta 1 94 546
443595 AF169312 Hs 9613 PPAR(gamma) angiopoietin related protein 1 94 467
409007 AL122107 Hs 49599 Homo sapiens mRNA, cDNA DKFZp434G0827 (f 1 94 3 59
408717 AF045458 Hs 47061 unc-51 (C etegans>-lιke kinase 1 1 94 429
420055 NM_001487 Hs 94672 GCN5 (general control of ammo-xid synt 1 94 338
430392 NM_000627 Hs 241257 latent transforming growth fxtor beta b 1 93 375
425078 NM 002599 Hs 154437 phosphodiesterase 2A, cGMP-sdmulated 1 93 406
423527 AI206965 Hs 105861 hypothetical protem FU13824 1 93 4 70
447151 AI022813 Hs 92679 Homo sapiens clone CDABP0014 mRNA sequen 1 91 3 77
422101 AW404176 Hs 111611 πbosomal protein L27 1 91 3 18
456653 AI807519 Hs 104520 Homo sapiens cDNA FLJ13694 fis, clone PL 1 91 341
443444 AW952619 Hs 17235 Homo sapiens clone TCCCIA00176 mRNA sequ 1 91 352
420924 R01026 Hs 245321 ESTs 1 91 3 22
426048 AI768853 Hs 134478 ESTs 1 90 356
414092 Z14244 Hs 75752 cytxhrome c oxidase subunit Vllb 1 90 4 15 415274 AF001548 Hs 78344 myosin heavy polypeptide 11 , smooth mus 190 588
428368 BE440042 Hs 83326 matnx metalloproteinase 3 (stromelysin 1 90 2 28
418418 R61527 Hs 237517 ESTs 1 90 356
449372 AA001266 Hs 133521 ESTs 1 89 390
438752 AW238673 Hs 146038 ESTs 1 89 524
428193 NM 004235 Kruppel-like fxtor 4 (gut) 1 89 5 21
433251 AB040955 Hs 322735 KIAA1522 protein 1 89 500
430560 Z28942 Hs 243960 N-myc downstream-regulated gene 2 1 89 709
427795 BE268268 Hs 180842 πbosomal protein L13 1 89 451
410209 AI583661 Hs 60548 hypothetical protein PR01635 1 89 335
449243 AW295031 Hs 198671 ESTs 1 89 426
420225 AW243046 Hs 282076 Homo sapiens mRNA for KIAA1650 protein 188 620
443932 AW888222 Hs 9973 teπsin 1 88 928
427929 BE613835 Hs 181159 Homo sapiens mRNA, cDNA DKFZp434F0217 (f 1 87 4 25
400078 Eos Control 1 87 673
422639 AI929377 Hs 173724 creadne kinase, brain 1 87 551
447374 AF263462 Hs 18376 KIAA1319 protein 1 87 342
430346 AK0OO331 Hs 297641 KIAA0462 protein 1 87 4 15
428223 AA424313 Hs 98402 ESTs 1 87 370
408792 L29433 Hs 47913 coaguladon fxtor X 1 87 408
433855 AA834082 Hs 307559 ESTs 1 87 4 16
451583 AI653797 Hs 24133 ESTs 1 87 381
426377 AK001921 Hs 169575 hypothedcal protein MGC2550 1 86 555
431647 AL138578 Hs 266738 hypothedcal protein dJ796M7 1 1 86 374
422055 NM 014320 Hs 111029 putative heme-bmding protein 1 86 468
425750 AL050276 Hs 42400 zinc finger protein 288 1 86 404
422491 AA338548 Hs 117546 neuronadn 1 86 4 37
438942 AW875398 Hs 6451 PRO0659 protein 1 85 506
400198 Eos Control 185 5 22
427136 AL117415 Hs 173716 a dismtegnn and metalloproteinase doma 1 85 341
427605 NM 000997 Hs 337445 nbosomal protein L37 1 85 4 73
418253 AA215539 Hs 283643 Homo sapiens cDNA FU11606 (is, clone HE 1 84 594
441912 AA971484 Hs 159938 ESTs 1 84 373
421632 AA825426 Hs 334689 ESTs, Weakly similar to ALU1 HUMAN ALU S 1 83 362
440602 AI743491 Hs 292692 ESTs 1 83 239
431882 NM_001426 Hs 271977 engrailed homolog 1 1 83 330
420772 AW752656 Hs 222707 KIAA1718 protein 1 83 373
429197 H24471 Hs 26930 ESTs, Weakly similar to T20272 hypothed 182 341
450796 NM 001988 Hs 25482 envoplakin 1 82 773
426928 AF037062 Hs 172914 retmol dehydrogenase 5 (11-cιs and 9-cι 1 82 338
415409 AW993701 NS1 -assxiated protein 1 1 82 360
401131 NM_001651* Homo sapiens aquapoπn 5 (AOP 1 82 553
421324 BE257515 Hs 103503 d∞xyπbonuclease l-like 2 1 81 553
400079 Eos Control 1 81 679
430513 AJO12008 Hs 241586 G6C protein 1 81 749
426508 W23184 Hs 170171 glulamate-ammonia ligase (glutamine synt 1 81 355
425883 AL137708 Hs 161031 Homo sapiens mRNA, cDNA DKFZp434K0322 (f 1 80 543
429191 AF065215 Hs 198161 phospholipase A2, group IVB (cytosolic) 1 79 590
432417 AL040360 Hs 162203 ESTs, Weakly similar to alternatively sp 1 79 363
406467 Target Exon 1 79 4 16
444135 AK000374 Hs 10346 hypothedcal protein FU20154 1 79 332
426402 BE387327 Hs 80475 polymerase (RNA) II (DNA dirxted) polyp 1 78 351
412524 AA417813 Hs 44208 hypothetical protein FLJ23153 1 78 3 72
425880 X01630 Hs 160786 argininosuxmate synthetase 1 78 329
400300 X03363 HER2 rxeptor tyrosine kinase (c-erb-b2 1 78 344
451304 M92642 Hs 26208 collagen, type XVI, alpha 1 1 78 357
400082 Eos Control 1 78 382
446603 NM 014835 Hs 15519 oxysterol-b ding protein-related protei 1 77 348
425415 M13903 Hs 157091 invducπn 1 77 464
400083 Eos Control 1 77 631
427620 NM 003705 Hs 179866 solute earner family 25 (mitxhoπdπal 1 76 347
446971 AI652143 Hs 288382 hypothedcal protein FU13111 1 76 4 21
429807 AK0O2138 Hs 306227 Homo sapiens cDNA FU11276 fis, clone PL 1 76 263
446560 AK001567 Hs 311002 Homo sapiens cDNA FLJ10705 fis, clone NT 1 76 382
412824 AW958075 Hs 11261 small prolme-πch protein 2A 1 76 4 31
439927 AA854650 Hs 124597 ESTs 1 75 363
410223 S73775 Hs 60708 calsequeston 1 (fast-twitch, skeletal m 1 75 3 79
414500 W24087 Hs 76285 DKFZP564B167 protein 1 75 355
448182 AF244137 Hs 20597 host cell fxtor homolog 1 75 340
439651 AF086480 Hs 56255 ESTs 1 75 255
430486 BE062109 Hs 241551 chlonde channel, calcium xtivated, fam 1 75 354
424389 AA339786 lymphxyte-spxific protein 1 1 75 448
450837 D58463 Hs 85969 hypothedcal protein FU12270 1 74 340
425920 AL049977 Hs 162209 claudin 8 1 74 333
435680 H50946 Hs 284183 Homo sapiens galxdn-related inhibitor 1 74 347
439639 AA370045 Hs 6607 AXIN1 up-regulated 1 73 522
416950 AL049798 Hs 80552 dermatoponbπ 1 73 4 99
400199 Eos Control 1 73 6 25
409737 AB011539 Hs 56186 EGF-like-domaπ, muldple 3 1 73 4 28
424420 BE614743 Hs 146688 prostaglandm E synthase 1 72 342
421545 AA292810 Hs 90034 hypothedcal protein FU21916 1 72 2 12
414323 NM 014759 Hs 334688 KIAA0273 gene product 1 71 4 82
407228 M25079 Hs 155376 hemoglobin, beta 1 70 7 02 406643 N77976 Hs 347939 hemoglobin, alpha 2 1 70 360
447299 AF043897 Hs 18075 chromosome 9 open reading frame 3 1 70 5 10
439733 AL365412 Hs 107203 hypothetical protein from EUROIMAGE 1759 1 69 292
415512 Y16270 Hs 78482 paralemmm 1 69 4 92
407100 R29657 gb F1-1179D 22 week old human fetal live 1 69 396
425503 W92517 Hs 158203 actin binding LIM protein 1 1 68 597
433738 AI684802 ESTs 1 68 288
406791 AI220684 Hs 347939 hemoglobin, alpha 2 1 68 344
428975 NM 004672 Hs 194694 mitogen-xdvated protein kinase kinase 1 68 274
435661 AF220263 Hs 193920 MOST2 protein 1 67 356
459317 BRCAIb Eos Control 1 67 334
426923 AF112977 Hs 172887 phytanoyl-CoA hydroxylase (Refsum diseas 1 67 453
426682 AV660038 Hs 2056 UDP glycosyltransferase 1 family, polype 1 67 336
417029 AW952192 Hs 273385 guanine nucleotide binding protein (G pr 1 67 5 22
437201 F29279 Hs 171625 hypothetical protein MGC14697 1 67 575
454478 AW805749 superoxide dismutase 2, mitxhondπal 1 67 455
406710 AI708347 Hs 184014 πbosomal protein L31 1 66 380
431593 NM 002108 Hs 276590 ESTs 1 66 245
457820 AA341497 Hs 31408 RAR (RAS like GTPASE) 1 66 244
441899 AI372588 Hs 8022 TU3A protem 1 66 406
414186 U33446 Hs 75799 protease, senne, 8 (prostasin) 1 65 652
418116 AA252457 Hs 86543 ESTs, Moderately simila to T00256 hypot 1 65 344
403105 Target Exon 1 64 412
450014 N41322 Hs 18441 ESTs 164 290
436685 W28661 Hs 5288 Homo sapiens mRNA cDNA DKFZp434M245 (fr 1 64 449
401429 C1400106 gι(4126465|db||8AA36581 1| (AB 1 64 382
420983 W95228 Hs 100764 cathepsin G 1 64 364
433126 AB021262 Hs 99816 beta-cateπm-mterxdng protein ICAT 1 63 329
428150 AW950547 Hs 70312 cytxhrome c oxidase subunit Vila polype 1 63 705
412295 AW088826 poly(A)-bιndmg protein, nuclear 1 1 63 401
430831 AA703239 Hs 269804 ESTs Weakly similar to ALU1.HUMAN ALU S 1 63 360
429348 AJ242859 Hs 199731 Langerhans cell spxific c-type Ixdn 1 62 264
407082 Z47055 gb Human partial cDNA sequence, farnesyl 1 62 213
452556 H78517 Hs 33905 ESTs 1 62 464
415688 AA166963 gb zo86d01 s1 Stratagene ovanan cancer 1 62 333
446515 AL048875 hypothetical protein DKFZp566H33 1 62 366
445919 T53519 Hs 334692 hypothetical protein MGC14141 1 62 565
447330 BE279949 Hs 18141 ladmin 1 1 61 561
412374 X01388 Hs 73849 apolipoprotein C-lil 1 61 5 18
400229 NMJ321724* Homo sapiens nuclear rxeptor 1 61 3 57
414814 014697 Hs 77393 famesyl diphosphate synthase (farnesyl 1 61 208
424397 AI950320 gb wp08d10 x1 NCI_CGAP_Kιd12 Homo sapien 1 60 359
451335 AB023192 Hs 26285 imidazoline rxeptor candidate 1 60 554
426156 BE244537 Hs 167382 natnuretic pepdde receptor A/guanylate 1 60 479
456267 AI127958 Hs 83393 cystatm E/M 1 60 250
436950 L05779 Hs 113 epoxide hydrolase 2, cytoplasmic 1 60 398
421397 S67368 Hs 103998 gamma-aminobutync xid (GABA) A rxepto 1 60 328
419092 J05581 Hs 89603 mucin 1, transmembrane 1 60 369
440160 BE560269 Hs 7010 NPD002 protein 1 59 249
417481 AA203281 Hs 6191 ESTs 1 59 360
406778 H06273 Hs 101651 Homo sapiens mRNA, cDNA DKFZp434C107 (fr 1 58 398
402991 Target Exon 1 58 336
425169 AW292500 Hs 128514 ESTs 1 58 400
446429 AI681807 Hs 201391 ESTs 1 58 320
426445 AA378739 Hs 187711 ESTs 1 57 363
425196 AL037915 Hs 155097 carbonic anhydrase II 1 57 344
422581 NM 016339 Hs 118562 Link guanine nudeodde exchange fxtor 1 57 355
440054 AW661947 Hs 6891 splicing fxtor, arginine/seπne-πch 6 1 56 339
415988 BE407713 Hs 78943 blxmycm hydrolase 1 56 243
441860 AW451330 Hs 348198 hypothetical protein FU20262 1 55 338
428462 AI571486 Hs 30258 ESTs 1 55 365
449518 BE395253 Hs 30861 ESTs 1 55 380
420075 AF142482 Hs 203846 TEA doman family member 3 1 55 381
406799 AA908548 gb og83g12 s1 NCLCGAP.Ovβ Homo sapiens 1 54 387
450787 AB006190 Hs 25475 aquaponn 7 1 54 406
419659 AB023206 Hs 92186 Leman ∞iled-coil protein 1 54 382
408543 N78098 Hs 44289 ESTs 1 54 3 10
410169 AI373741 Hs 59384 hypothetical protein MGC3047 1 54 473
426068 AF029778 Hs 166154 jagged 2 1 54 482
432191 AA043193 Hs 273186 hypothetical protein, clone Telethon(lta 1 54 583
415166 NM 003652 Hs 78068 carboxypepddase Z 1 54 458
410048 W76467 Hs 343874 proline oxidase homolog 1 54 466
430502 AI123657 Hs 127264 ESTs, Weakly similar to JC5314 CDC28/cdc 1 53 341
433640 AW390125 Hs 240443 Homo sapiens cDNA FU23538 fis, clone L 1 53 4 57
413353 AW293542 Hs 75309 eukaryotic translation elongation fxtor 1 53 359
431021 AI869664 thiosulfate sulfurtransferase (rhodanese 1 53 373
431243 U46455 Hs 252189 syndecan 4 (amphiglycan, ryudxan) 1 52 609
433019 AI208513 Hs 279915 translocase of inner mitxhondπal membr 1 52 449
406801 AW242054 Hs 190813 nbosomal protem L9 1 51 556
427461 AA531527 Hs 332040 hypothetical protein MGC13010 1 51 377
432894 AW167668 Hs 279772 brain spxific prote 1 51 672
415550 L13720 Hs 78501 growth aπest-spxific 6 1 50 402
424707 BE061914 Hs 10844 Homo sapiens cDNA FU14476 fis, clone MA 1 49 421 445624 AW140103 Hs 78880 ilvB (bxtenal xetolxtate synlhase)-l 1 48 361
445071 AI280246 Hs 149504 ESTs 1 48 339
440763 AB028988 Hs 7407 KIAA1065 protein 1 48 403
451988 AF263928 Hs 27410 papillomavirus regulatory fxtor PRF-1 1 47 358
427841 AW883367 hypothetical protein MGC5306 1 47 361
426335 AI054347 Hs 2017 nbosomal protein L38 1 47 376
454098 W27953 Hs 292911 Plakophilin 1 46 295
456766 R87310 Hs 7740 oxysterol binding protein-like 1 1 46 340
440526 AI832243 ESTs 1 46 338
452586 AW958479 Hs 289043 spindlin 1 45 348
433399 N46406 Hs 84700 similar to phosphatidylcholine transfer 1 45 344
430238 N72519 Hs 236545 hydroxyxid oxidase 2 (long chan) 1 45 400
425456 T70445 Hs 157850 πbosomal protein L9 1 5 4 79
411085 AF022991 Hs 68398 period (Drosophila) homolog 1 1 5 443
433638 AW872507 Hs 3462 cytxhrome c oxidase subunit Vile 1 44 389
445156 N89367 Hs 12373 adenylate cyclase 6 1 44 360
446576 AI659477 dystroglycan 1 (dystroph -assxiated gl 1 44 307
440433 AA252452 Hs 7187 hypothedcal protein FU10707 1 43 367
434536 H14486 Hs 3903 Cdc42 effector protein 4, binder of Rho 142 3 5
423513 AF035960 Hs 129719 transglutaminase 5 1 42 318
418681 AA287786 Hs 23449 insulin rxeptor tyrosine kinase substra 142 338
421935 AA131632 Hs 109672 CMP-NeuAC (beta)-N-acetylgalxtosamιπιde 141 404
406712 M31212 Hs 77385 myosin, light polypepdde 6, alkali, smo 1 41 427
413944 AW001579 Hs 9645 Homo sapiens mRNA for KIAA1741 protein, 1 41 380
435879 AW084463 Hs 30002 SH5contanιπg protein SH3GLB2. KIAA1848 1 41 355
417967 BE244373 Hs 1119 nuclear rxeptor subfamily 4, group A m 1 40 407
412669 AW880841 Hs 96908 p53-ιnduced protein 1 40 359
415523 AL042003 Hs 296847 cell matnx adhesion regulator 1 40 438
406713 U02629 Hs 77385 myosin, light polypepdde 6, alkali, smo 1 39 403
439606 W79123 Hs 58561 G protem-∞upled rxeptor 87 1 39 365
430135 NM 000035 Hs 234234 aldolase B, fructose-bisphosphate 1 37 399
422682 W05238 Hs 94316 ESTs, Weakly simila to T31613 hypothed 1 36 330
408198 AA131111 gb zo16b06 r1 Stratagene colon (937204) 1 36 333
419600 AA448958 Hs 91481 NEU1 protein 1 35 349
437141 BE304917 Hs 31097 hypothedcal protein FU21478 1 34 347
408250 R92918 Hs 19597 KIAA1694 protein 1 34 389
430012 NM 015373 Hs 227637 chromosome 22 open reading frame 2 1 32 4 24
425183 W76098 Hs 19223 HCCA2 protein 1 32 352
427706 AW971225 Hs 293800 ESTs, Weakly similar to ALU1_HUMAN ALU S 1 32 350
438303 A8028998 HS 6147 KIAA1075 protein 1 32 371
406800 AA505535 gb nh84h10 s1 NCI_CGAP_B 1 Homo sapien 1 32 365
442533 AA161224 Hs8372 ubiquinol-cytochrome c reductase (64kD) 1 32 414
428475 AF172940 Hs 184542 CGI- 127 protein 1 31 343
406742 AI468091 Hs 279860 tumor protein, translationally-controlle 1 30 334
432295 BE091049 Hs 343665 πbosomal protein S15a 1 30 329
422959 AV647015 paired immunoglobulm-like receptor beta 1 28 353
402956 ENSP00000244002* KIAA1335 protein (Fragm 1 24 338
406743 AA911568 Hs 279860 tumor protein, translationally-controlle 1 24 370
437142 AI791617 Hs 145068 ESTs, Moderately similar to A46010 X-lm 1 23 348
424372 AW952803 Hs 21732 Homo sapiens cDNA FLJ 11780 fis, clone HE 1 18 244
414716 AF199598 Hs 97044 Kv channel-mterxdng protein 2 1 18 343
431931 AB035302 Hs 272212 cadhenn 9, type 2 (T1-cadheπn) 1 15 249
406587 C15000544* gι|54S4148|ref]NP_006368 1| U 1 06 225
409574 AW419080 Hs 250645 ESTs 1 00 360
417435 NM_005181 Hs 82129 carbonic anhydrase III, muscle sp∞rfic 1 00 344
402075 ENSP00000251056* Plasma membrane calcium 1 00 337
422330 D30783 Hs 115263 epiregulin 1 00 335
418986 AI123555 Hs 81796 ESTs 1 00 3 28
404175 Target Exon 1 00 308
452640 AA027115 Hs 100206 ESTs, Weakly similar to A53856 aryl xyl 1 00 282
443564 AI921685 Hs 199713 ESTs 1 00 251
TABLE 64B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Axession Genbank xcession numbers
Pkey CAT Numbei r Accession
412636 1438.1 M77830 NM.004415 AF139065 BG681115 BG740377 BI712964 BGC
J05211 BG698865 BG740734 BG680618 BG739778 BI765807 BM353403 BM353248 AW177784 AW205789 AW951576 AW848592 BE182164 8F149266 BE940187 BI060445 BI060444 BF350983 BE720095 BE720069 BE715154 BE082584 BE082576 BE004047 AA857316 BI039774 BE713818 BE713548 AW1702538E160433 BI039775 AW886475 BM462504 BE931734 BF149264 AA340777 BF381183 BG621737 AU127260 AW364859 BF993352 BG223489 BE819009 BF381184 BE715956 R58704 AA852212 AW366566 BI090358 BF0877078E819046 BE819005 AA377127 BE073467 BE819069 BE819048 BI036306 BG990973 BI040954 BF919911 AU140155 AI951766 AI434518 AW804674 BF752969 BE837009 BE925826 BF14926S AW995615 BE814264 BI039782 AU140407 BE144243 BE709863 BF985642 BE001923 BF933510 AW265328 BG436319 BE182166 AW365175 AW847688 BE818280 AW177933 BF873679 AW178000 BE082526 BF476866 BF0869948F592276 BE082507 BE082514 BE082505 BF873693 AW068840AW847678 BF804153AW36S157 BE813930 BE002030AW365153 8E184941 8F749421 BE184920 BF839562 BE184933 BF842254 8E698470 BE931048 BF999889 BF368816 BE184924 BE159646 BE714632 BE184948 BG986845 AA131128 AA099891 W39488 C04715 BF096124 BE865341 AW799304 AL603116 BE 149760 BE705967 BE705966 BE705968 AW848723 AW376699 AW376817 AW376697 BG005097 BF751115 BE696084 AW848371 AW376782 AW848789 AW849074 AW361413 BF927725 BF094211 AW997139 BE865474 BE185187 BE156621 BE715089 BE713297 BE713298 BE179915 AW799309 BF872345 BF088676 BE705939 AW752599 BG005197 BF350086 BE715196 BE715155 BF752396 BF093817 BF831190 BF752409 BE006561 BG959922 BF094833 BF094748 BF094583 AW377699 AW607238 BE082519 AW377700 BF349467 AI190590 AI554403 AI392926 AU158477 BI467252 AU159919 AI7608168F082516 AI439101 AA451923 AI340326 AI590975 BI791553 AI700963 AI142882 AA039975 AA946936 AA644381 BM314884 AA702424 AI417612 AW190555 AI220573 AI304772 AI270345 AI627383 AA552300 AI911702 AW166807 AI346078 W95070 AA149191 AA026864 AI830049 AW780435 AI078449 AI819984 AI858282 BI468588 AI860584 AI025932 AA026047 AA703232 AA658154 AA515500 AW192085 AA918281 T77861 AI927207 AI205263 BF082491 AW021347 AI568096 BE939862 AA088866 D12062 AA056527 AA782109 W19287 W02156 AW150038 AA022701 T87181 H44405AI910434 BF082513 AI494069 AI270O27 AI635878 AA128330 BG681425 BE706078 R20904 BG680O59 BG676647 BF764409 AA026654 AV745530 BI762796 BG287391 AW798780 BE706045 BE926470 AW799118 BF087996 BE002273 AW879451 AI571075 BE067786 AV721320 AI022862 N29754 C03378 N84767 AA131077 H30146 BE714290 AI686869 AI568892 AI915596 AW105614 AI887258 AI538577 BE926474 BE067737 BG319486 AA247685 AW798883 AW103521 BF989173 AW860878 BE939707 BE185750 BE714064 BE713903 BE713868 BE713763 BG950164 BE713810 AW365151 BG955489 BE005272 BF915937 AW365148 AI905927 BF992780 AW853812 BG954443 BI770853 BG679406 BG740832 BG681087 BG698430 AA455100 T87267 BE696209 BE696210 81089483 BE006273 BE872225 AW391912 BE925515 BG677012 BG741970 AA026480 BE705999 BG677157 BE009090 BG681378 BE712291 BG961498 BG678984 BI040941 AA337270 AW384371 AW847442 BI058659 BE813665 W95048 W25458 AW177786 AA025851 BE931733 BF154837 BG949393 BE714441 AW996245 BE711801 AI284090 BE064323 BE719390 BE940148 BG991212 BF375714 BF349522 BG996267 T48793 BI013292 BE001925 AW365156 AW365154 AW606653 BF763109 BE931637 BE167181 BE713879 BF354008 BF678726 H90899 AW365145 W38382 AI498487 407328 534268.1 AI673735 AA978066 427890 1373988.1 AA417099 AA435761 AA972917 AI660387 440116 454673.1 R69942 BG655457 BF111453 AI149320 N23160 AI446431 AI758316 AV741781 BI791950 BM055014 AI798851 AA865357 AI417230 N67277 T55592
T52179 444105 649788.1 A 189097 AI123917 A1123926 431926 1237041.1 AW972724 AA877998 AA522631 AU185388
424399 2196.1 NM.058173 AF414087 W72837 BF742809 AW070916 BE092421 AI905687 AA340069 BE074512 AI905623 AI905633 BG202312 W72838 AI139456
BG218084 BE926938 BE186013 AW176044 AW291950 BG185269 BG197186 BG192597 BG183176 BG207535 AI127172 BE815819 AI905624 R75793 BG202313 AI905837 BE815853 426101 3211.1 AL049987 BG620667 BG571984 AW362842 BE150456 BE326465AW872412 AA868553 AI024689AA442638AA813604 AA442648 AA663108
AA442379 AA229448 N56349 AA460220 AW971193 AA453725 AI742087 AI860142 AW769479 AI917507 AI860141 BE045272 AW277065 AI921333 AI354470 BE466760 AI827987 AI005467 AA833517 AA563934 AA522837 AA812876 AW020895 AA600372 AA663178 AI187977 AA229164 AW270324 AA703066 T78981 AA632986 BE708493 R31132 AI253986 AI916737 T84796 T84294 AW961515 AI459289 BF109829 BI491853 AI084517 AW103830 BE835233 AI472712 AV741009 AA551512 N28268 AA436880 AA447794 BE835410 BE835385 BE818352 BE818350 R64648 BE646467 AA493776 AA437299 BE818343 R95914 R31089 BF576826 AU186065 BF802058 AI217018 AA247541 AI191725 BE766918 438962 195763 1 AI207343 BF813684 BF928775 AA828585 445493 423456 1 AV711317 AI809938 AI808768 AI240593 AI915771
407102 7177.2 AW945170 BF930905 F33652 BG057818 AI368018 AI421485 AI300352 AI378525 AI264177 AI276281 AI245302 AI281050 AI190036 AW451438
AW242903 AA910870 F22289 F19647 F22375 AW473816 BF445785 AA774528 F33447 C01077 AW772227 F17759 H42812 R09701 AA349096 R48772 H42892 H42537 R47898 N28263 H25721 F32386 H43971 R48205 F21390 H45809 AA007629 R47897 R83734 H45844 AW983653 H43970 H42536 H24495 R48875 H42961 H22079 R86018 421998 133592.1 BI757233 BG911321 BF351759 AW244016 AW026834 AW024260 AI420138 AA779354 AI093360 AI934858 AW151292 AI373133 AI335587 AI969728 AA101632 BE218525 AI802114 AI783721 AA845265 AW088826 AI832852 F03967 AI611148 AI720358 AW293764 N91161 R79192 W85852 AW771263 BG820263 BG012864 R74441 R86080 W04256 BE707244 BF899452 BE327552 BE669500 AI492388 AI241532 BF448184 AI209012 AA886528 N70309 AW582776 BF110563 BF448329 BE326537 AW770471 BF444926 BE674147 AI793266 AI991774 AI807726 AI218667 AA301750 R44328 408239 103120.1 AW469418AA053401 AA053416
437611 240436.1 H93046 AA897108 AI652046 AA761626 BF882276 N68615 T88896 H93912 T84424 456332 21353.10 BG740624 AV720262 BG198346 BG215119 AW841716 AA228357 AW841786 458222 631332 1 AA932742 AW593558 AW139592 434206 185910 BF591031 AW205438 AA933791 AI434866 BF513564 AI191480 AI972330 AI582824 AW779392 AI359970 AI199117 AI910783 BF800971 AA627401
AI799778 BF222639 AI937737 AW136973 400295 2196.1 NM.058173 AF414087 W72837 BF742809 AW070916 BE092421 AI905687 AA340069 BE074512 AI905623 AI905633 BG202312 W72838 AI139456
BG218084 BE926938 BE186013 AW176044 AW291950 BG185269 BG197186 BG192597 BG183176 BG207535 AI127172 BE815819 AI905624 R75793 BG202313 AI905837 BE815853 417054 12405.2 BG533564 BG618564 AW296119 AI269233 BF508328 AW364777 AW292258 AA371049 AI452471 AI092522 BG618376 AL049080 AA631068
BG564643 T53833 AV702544 BG533452 AV705004 AA588281 T28665 BG569026 AV646874 AV647253 AV647455 AV647749 BI759444 AV652457 AV695354 AV696010 AV697248 BG617586 AV722549 AI435836 AI590676 AI245019 AW338243 AA530898052191 AI435352 D57473 BG566952 AI420505 AA035245 AV704972 BG564113 AI439237 AI287456 AV695686 AA349017 423974 888155.1 AL118754 AA333202 H38001
412668 33230.1 AK057749 AI701055 AA115476 AI633570 AI435607 AW173392 AI092468 AI989318 AA833891 AW295964 AI804107 AI767415 AI473818 AI076758
AA278949 AA428547 N31385 H82560 AA464804 AA809073 AA832476 AW295298 BF108690 AI492243 N22394 AA487175 AA431891 AW070941 AA278823 AA707840 AI346067 AI184307 AA936342 AI288633 AA425697 AI435960 AI301433 AA993394 AI917652 AA487234 AA490964 AA937925 AI301378 AI783840 AI093652 AA723864 BF001378 BI818971 BI762256 AW957064 BG720359 BI821176 BI906440 AI472868 AL523506 BF962934 BF960650 BI837618 BF956256 AA487349 BF961475 AA354431 AA115452 AA491157 N75632 BF962141 AL562216 BI754640 N24091 R00062 AI963686 T56529 AU185624 T56460 H97658 BI752843 BI819132 AA210796
444726 3503_2 BG285809 BE940673 BG432524 BE157554 BG676980 AU144284 AI745383 AU159045 AI693500 AW293668 AW371408 BE856107 AI338042 AW188320 AI698246 BE673290 AW297653 AA156532 AI017342 AI916754 Al 190644 Al 184302 AA857671 BE857018 AI307420 AI318157 AW204327 AW664668 AW274339 AA582788 AI345741 AW301433 AI873468 AW137388 BF718731 BF718413 AA877495 BF001575 AI824693 AW849604 AW849405 AW849396 AW849173 BE673179 AI611327 AA705753 BE715478 AW849414 AW849399 AI085759 AI140849 T67412 AI889885 AW104647 AI912495 AI889874 AI744241 BE717113 BE717108 BE715564 AI872527 AA029457 C00338 AI469558 BE715577 AA045413 BF843813
451184 1531_4 Z99386 AV716301 BE222333 AI949687 BF732426 AI494086 AV721430 AW577332 N68315 BE672030 AI084440 AI250908 N50901 AA757364 BF515264 Al 186231 BE466036 AW631313 AA993514 N54411 BG057515 AW013895 N77963 AA708723 AI273295 N59093 AA522665 AI871574 AA505521 AA812256 AA553841 AW467057 W68650 Al 168772 AA988308 AA910057 AI868258 AA918322 AI335847 AA621494 AA904390 AI760007 AU146694 AV758440 BM142562 N66507 AI674563 AW628584 AI263902 BF223368 AI090490 AI452918 N71423 AA062767 T94332 AA016003 BG681608 AA082426 AA029451 N71873 BF437845 T54154 AV741757 443072 449629.1 AV734838 AI937532 AI032318 AW749500 AA091720
437596 2875.1 BC022398 AV743635 AW976922 AW152652 AA910013 AA834629 BG536317 AW849807 AV713062 AI684337 BE044081 AA761490
411962 2307710.1 AA099050 AA099526 T47733 440469 1030831.1 AW753257 AA886068 D61974
450860 40397.1 AK026697 BE938558 BE843975 BE843962 AW304313 AI735759 AA021055 AI769145 AI188319 BF064105 AI677654 AA723627 AA781580 AI611167
BE162152 R77997 BG059091 AV722360 AA370451 AA033786 AV729790 AW953851 AW953855 BE504303 AI765853 BF059302 AA410685 AI978745 AA399236 BG149495 BE670366 AI694777 BE503109 AA633474 AI700568 AI432181 AI637714 AW302164 AA196790 AI928519 BE673464 BF437523 AI281974 AI306156 AW418884 AA523952 AA683187 AW075563 AA877270 AW204404 AW771341 AI913892 AW770312 AW242851 AU154858 AA021007 AI521932 AA034044 AI760631 R34679 AI915923 AI911609 AW242360 AA059025 AA370450 BF432186 AW862279 AW859976 BE159936 BF514075 BI057841 R34781 R77900AA011413 418481 17381.1 S53911 NM.001773AL572644 AL550179 AI688653 AW025002 AW614285 AU158779 AI017002 AA434387 AI252665 AI262206 AU147582 AI144193
AW952860 AI128776 AI017793AI160509 AA906021 AI149563AU154950AI128488 W74409AI970362 AI141453 AU158772 W58493 BM148338 R73091 AW020496 BI491517 AA022917 AI432610 AI879448 R69099 AI708954 AW014274 AA483672 AA528783 AA912271 AI926942 BE677587 AI874217 AA152376 AA640408 AI287334 BF830285 AA311473 C18678 AA922603 C00910 AI124073 R38730 AA043439 W94644 W58646 AA664247 BE061934 H01096 R69613 AI383162 AU133723 AA311526 R67942 H01097 H72113 R72430 R39494 AV744074 AA535925 BI759288 BI052385 BF854687 AW608286 AA043438 R72478 AL513811 R69214 AA188435 AA054965 412477 8669.2 AI220117 AI857837 AI218371 BM091400 AI304964 AI198508 AI400738 AW571549 AW950042 AI089943 AA437280 AU150878 BF197070 AI267984
BF594181 BF196688 AI433152 AI338921 AI620364 AI280197 AA652531 AI674938 AI342447 AI620350 AI281295 AI148621 N54787 AI338121 AI281153 N51899 AI087072 AA954788 AW069054 AI346309 BG529629 AI340135 BF083036 AI167365 AW819657 AA935468 AI467868 AW148701
AI383720 BE047685 AW015498 AA937149 AA708346 AW771478 AW802508 H53334 AW389204 AW798230 AI553922 AI560688 AW950043 AI961682 AV706506 R01853 AA126514 N62757 AI536893 AI926052 AI418720 N99964 AI568933 AI915737 AI080691 AI185358 N48996 N68575 H82824 H60037 AI247247 T95664 BF593863 AI749637 AW088541 AA991294 AA887452 AI073726 AA633132 AA629674 AA629649 AA629656 AA578595 AI168758 AA804572 AI085786 AA994396 AA991209 AA948663 AA929054 AA927952 T87001 AA928210 AA629296 AW802267 AW384129 BF744400 AA194110 AI382839 AA194837 AA406284 AI250750 R37035 AI525586 W01244
412947 1568055.1 AA122277 BE183957 BE183956 432908 452541.1 AF150424 AI861896 AA570057 AV738855
434230 41110 1 AF119900 NM 018539AA702388 N53043 BF351064 N70103AI207469AA551569AW383189W00906 W00935 N54252
414665 23751 3 BG567713AW665841 AI814924 AW978339 AW264036 AI373950AW183157AW082249 AI201658AI364196 AA150743AA160873 AA453757 BF871646 BF871640AA565311 AA989511 R10152AA807154 T77900AV751591
412446 63467.1 BC021735 AI669212 AL120184 AI769949 BE701002 BE184363 BE819031 BG7022388F090049 BF963318 BF961912 BF943013 AA934514 AA151245
BF960659 AA987907 Z41449 BF908059 BF908053 BF908049 BE699424 BF908060 BF962832 BF952020 BF963134 BI035538 BF908052 BF908057 BF090026 BF943158 AI632924 BF512340 BF952021 BF960776 BF943437 BF942847 AI768015 F09778 F04816 F02721 AA102645 AI633838 AA617929 BF947001 BI035448 BE935876 AW890837 AW898604 BF957405 BF963433 BG704815 434442 111738 1 AA662701 AA633929AA737415
410453 1027545 1 BE065904AW7490368E175748 BE175746 BE175747 BE175745T64217 454065 517162.1 BE394588AW024754 BE183167 BE183166 BE378353 434433 111338.1 AA633408AW749955AW629759AI651005
424982 25362 1 AK057547 BG181248 AA883756 F25670 AA778128 F27657 F18914 F25171 AA178844 F21556 F25872 F20457 F27617 F36059 F34817 F26967 F25922 F31278 F34666 F01176 F36333 F01226 F27406 F27130 F28742 F24126 F29891 AA195955 AA086351 W69291 F25880 F32791 F31311
F32380 F25216 F19679 F18656 F29700 F24954 F32741 F30404 F35470 F33989 F33141 F36382 F34118 F17714 AA176345 F24700 AA550940 F18617 F16859 F15633 F34675 F16528 F17281 AA086388 F30859 F21852 C02644 F29425 F25286 C03553 F35259 W80691 F16457 F24094 F16783 AA180319 F28443 F17763 F17448 F00542 AA197179 AA193012 445029 82093.1 BG566720 AA010276 W92098 BE837833 BF541660 AW889587 AI651246 AI339033 AI078183 AI686504 AA813616 BF056955 R43664 BF509917 AW663717 W95054 AI382907 AI399929 F10511 AA427819 AW2694088E825398 BG654856 AA037082 AI203007 AW593522 H65211 AA010218
408839 2346691 AI355222 BF378422 AA366587 BF874552 AW277084 R26970 D79194 R27662
432093 12370111 AW972670 AA525808 H28359 H28383
406790 00 AA293303 AA492458 AA948195 AI341912 AI436673
4 ,3.-6.-3..1,4- 1 ,4-2,.7.7,4-_1, AA708982 AI095911 AI983409
440066999977 229988667711 NA
400232 9281 AL581381 BE220341 AI695121 BG149299 AI205526 AI968389 BI752979 AI291204 AI954763 AA344460 AA344581 BF082319 AU125758 BE825566 AA954549 AI286069 AA948280 BG149854 BI862122 AI024440 AI090013 NM_001895 M55265 BC002615 BC011668 BM452475 AL560958 AU125134 BE408670 AL134963 AI589577 AI952244 AW972197 AW403214 AW069872 AI804464 AU123365 AI342226 H50982 AV738572 R94284 BG536938 AI970166 AI858205 J02853 AU131772 BE841258 AW867858 AA419595 AL597675 BF361319 AW877122 AW877060 AW876962 AU126276 AA279620 ' AA805295 AU132198 AU130091 AI375624 AW183031 AU129003 AI373257 H92896 BE244655 AW028253 AW571546 BI258630 AI807134 AW672915
AW893438 BF036080 AW054815 AW963200 AI797895 AA604241 AI014611 BE092080 BE092076 AA639870 AA714906 N39594 AA173857 AW951102 AW951101 BG823603 AI478558 R32009 AW149282 BG818283 R69507 T29481 BE766560 AI693579 H06201
400307 271102 AF005081 BG193848
, 4„54,9.4-,7. 10838 _24-,_1, AW846590AW846615AW846584AW846592AW846621 AW846610 4 41177331144 2 2009977008822.11 N68168 N69188 N90450
410531 10305591 H88044 BE156092 AW752953
407394 271102 AF005081 BG193848
434987 1219851 AW975114 AI096634 AI767001 AA658364 AW517542 „ 44„81.-4,-4, — 486 ,5,„3_ϊ, BC015871 AI521618 AI471709 AW169230 BG539605BI058963BI058949 BG548398 BG952412AW842037 AW842040AW890573 4 43399551188 2 233884422.11 AF086341 W76326W72300
437124 594081 AL050013 BG939500 AW969191 AA769925 AI377973 AI625545 AA811365 AA521114 N24705 AI379579 AA424899 AI684671 AA829715 AI453010 N35401 AA677452 AA504340 AI209149 AA883574 AI379062 AI084455 AI280147 AA644327 BF432508 N27873 N47364 N34880 AI147024 T86860 AI219716 AA960926 H2S544 BI857123 AW960489 AA599099 AA765246 AA328537 BG434703 AA890373 AA424765 AI292318 AA829886 N95742 AI218758 H25588 N36282 AA024987 N36687 BI919187 N49471 AA889970 AW166152 AA468546 AI262504 AI452782 AA554458 AA807080 AA724542 AW102730AA909978 AW118134 AW827241 W56431 BM127381 BF436987AI016509AW663972 BM127686 C15552 N63435 N51744T98800 N56980
BG108636 N49381 R49886 D61278 BI756612 AA508234 R49885 BF850422 432212 629625.1 AW972351 AW182936 AI478370 AA528309 BG997292 AW137742 AI632006 AA775020 AA961625 W86628 BF112014 AI275423 AI680786 410669 4273 16 AW796921 AW798102 AW805749 AW805872 BF985060 AW794380 BF380449 AW794466 AW794538
434346 H1094.14 AK056896 AI924216 AI660493 A1984141 AI991272 AA593860 A1983793 AI346155 AI274929 AI281211 AI821178 BC020841 BF352476 BF843140 BF917041 W80832 AA630445 BF350167 BE162052 BE931808 AI572329 BG536379
452467 90115 1 AA026381 AW500815 AI806691 AW502933AW303573 BE328059AI201422BE673566AW182125 H13705
417553 258857.1 AL545411 AI096369 BF431750 AI130946 W60065 W80663 AA258580 W73279 W76156 W80662 AW058658 AI204699 W60115 N56751 N30878
AI769345 R71250 AI363766 R22777 R17009 R27985 R28243 423031 14129.4 AI278995 AW964552 AI885189 A1571775 AI660803 AI299327 AI719401 Z39652 H25636 BF091855 AI218354 AI928704 AI817774 AI885495 AI695453 BF340929AV749610
428193 430.1 AF105036 U70663 NM 004235 AF022184 AU141767 AU141110 AL040569 D44830 BI011351 AL575805 AI290876 AI014784 AI393429 AI266211
AW074303 AA620711 BF197792 AW008766 D25944 AI687397 AA621680 AV714408 BF446905 BM314505 BF514079 BM314197 AA845201 AW874084 BE720622 AI127241 AA236239 AI679709 AI679135 AI572470 AA573434 AI568487 BE049325 AA687950 BG925989 AI338031 AI36S073 AI024576 AA298805 H04001 H45668 BG682146 AL552388 BI462361 BG547513 BG89686381256661 415409 34886.1 AK056188 BM455117 BG527027AA480032AW993701 AA164703AL537682AA836491 AA515961 AL537681 BF437856 AA683484 AW152367
AI769509 AA907521 AW105404 AI521557 AA670165 AI564471 N22106 AA479060 AI472006 AA164704 N30335 AI224391 AA969890 BE856571 AI284716 AA918763 AA773661 BG942266 AA507486 AI934383 AA502847 AA516351 AA653124 AI360432 R75834 AA636111 AI972795 BI870444 BE891404 AI631952 AI346655 AI285030 AA928471 AL520908 AA385324 D80465 D80464 AI554371 AI907655 BF221524 AI091545 AA411631 AI028196 AA406581 AA228115 AA227977 BG929224 BF593158 400300 1507.2 AW866366AI149552AA010880AA627121 AA778233 BE936663 BG998642 AA652426AI240816 N80859T29383 M11730 NM.004448 X03363
BF155195 BF155196 BG954721 BI052629 BG954765 BG013608 AI907188 BG675003 BG979151 BF743441 BF083392 BF083386 BF756761 BE838913 AL552065 AV697118 BF736873 BG957211 AW175784 AI904229 AW175630 R70549 AW175762 AI904242 BG289938 AI376867 AA481939 AA446928 AI076724 AW841882 AA985406 BE830620 BE074596 AL552189 AI907227 BE179717 BG998658 BE179931 AW175631 AV689870 AV691022 AA025156 AI624297 AW071132 BG951486 AI907206 BF348688 AI904222 BG954414 AI590133 AW080151 AA480116 BF360696 AI689419 N75837 AW373844 BF991704 BG222449 BI030443 BE698057 BG954850 AI905836 BF984111 AU123871 BF834727 AI904283 AI909847 BF757857
BF923905 BG283493 AA299475 R80150 BG987145 BF837559 BG469759 AA496412 BF758339 BG957192 AW373869 BG952345 BF229957 BE697472 BE697475 AA011005 BG005000 T56558 AA908196 AA716585 424389 1059.4 BG190758 AW961118 W77994 AA339877 AW845121 AW845129 BG181820 BE716719 AI125483 AI161017 W73951 AI250771 AA912611 AA339786 BE838286 BE838282 BE716636 AA777158 W94063 BE716628 BE716625 BE838371 BF371044 BE716631 BE716402
433738 593682 1 AL037666 AW607643 AI280025 AL037665 AW291619 AI280142 AA765506 AI684802 AW085941 AI688062
454478 4273 16 AW796921 AW798102 AW805749 AW805872 BF985060 AW794380 BF380449 AW794466 AW794538
412295 133592.1 BI757233 BG911321 8F351759 AW244016 AW026834 AW024260 AI420138 AA779354 AI093360 AI934858 AW151292 AI373133 AI335587 AI969728 AA101632 BE218525 AI802114 AI783721 AA845265 AW088826 AI832852 F03967 AI611148 AI720358 AW293764 N91161 R79192 W85852 AW771263 BG820263 BG012864 R74441 R86080 W04256 BE707244 BF899452 BE327552 BE66950 AI492388 AI241532 BF448184 AI209012 AA886528 N70309 AW582776 BF110563 BF448329 BE326537 AW770471 BF444926 BE674147 AI793266 AI991774 AI807726 AI218667 AA301750 R44328
415688 1235745.1 AW971218AA493942 AA166963
446515 11382 1 BE178766 AI909166 W79619 AA346208 N54022 R98542 AA005419 AA890703 AW510832 BM126988 BF528760 AA858017 BM126698 AI423291
AW173383 AA742205 AI693060 AA746651 AA490661 AW241710 AI635076 AI073737 AA875841 AA907556 N50889 AW438573 AW273496 AA633604 AW303990 AI685291 AI076127 AW470084 AI022394 AI298624 AA253418 W79538 AA719820 AA253398 AI400823 AW294450 AI022396 AA907775 BF445607 AA699324 AA025643 AW573103 AI167444 AA580002 AW103144 AI640654 AA857115 AA923021 AI066439 AI358865 AA843287 AI824604 AA732370 AW002202 AI219540 AA621697 AI950639 AA904277 AI867527 BF437695 AA808593 AI784144 AI648539 AV752557 AV752603 AA02S642 AA764744 AW149075 N30700 H92303 W79523 AI762795 AA282784 H78923 AA252879 H98107 R23754 AA005152 N99239 N74632 H80133 H24710 R38907 R66368 R42466 R52648 H11010 R98493
400229 462_3 NM.021724 M24898 X72631 BE550221 BF436030 F18898 AL567477 BG033127 BG747927 BF823716 AA371902 AL137978 AL577786 BI490529 AA021622 AA151679 AA745053 AA454168 R85506 AA016015
424397 893246.1 AI950320 AA340023
406799 0 0 AA908548
431021 10409 1 NM.003312 BC010148 AK000862087292 BG709214 BF972766 BG740474 BI771592 BI159859 BI820468 BI523933 AI869664 AA314620 BF724353
BG194276 BG1952828I524679 BF435589 AI300546 AA481682 AW780207 AI800832 AI380540 BE222877 AW300707 AA481445 AW015893 AI381541 AA768558 AI138798 AA432063 AA948713 AI869485 AI307419 AI336589 AI301672 BF055581 AI312785 AI521208 AI927918 AI989759 M78015 BF718621 AI927654 AI795909 AI335381 BF334524 AW007444 AA706797 AA975178 AA884739 AA443837 AA933897 AI826464 AI271737 AA053419 H79704 AI984483 BG952614 BF345358 AW083336 AA643660 AI478232 AA603071 BE714413 AW078660 AW070418 R02364 BG925951 AL568823 AA053459 AA446748 BG954446 BF760569
427841 12616 8 W74622 BF055071 AW135949 AI184884 AI393557 AI830476 AA416697 AI400728 AW183266 T83655 AW883367 AI963037 BF964042
440526 1078274 1 AI832243AI742643AW839701 AA888497
446576 629517 1 BI517686 T89902 BI518252 AI659477 T89628 H22349
408198 102854 1 AA132859 AA131111 AA053057
406800 0 0 AA505535
422959 MH905 3 AJ400845 AI954159 AL041618 AI028269 AA769325 AW780241 AW129462 AI271476 BF798303 AA836991 AW273346 AI436321 AI375545 AL040967 AA889495 AI922524 AA598667 AA423804 AL040910 N80292 AI954063 AI923968 AI400578 AA748499 BE677845 AW020788 AA860230 AW519209 AA767391 AI860419 AA476935 AW452389 AI017695 AA806940 BI497005 AI051533 AI650706 AI811516 AA609569 AI439198 BF430946 AA749268 AI624860 AI784422 BI491753 AI206880 BE671796 AI431957 AI187038 AI678429 AI273421 AA897667 AA586499 BE241923 AF161081 NM_013440 BE073169 AI700673 AV699081 AV684786 AV688O81 AV689220AV689216AA132636 BF086186 BF917106AV762653 BI064033 BE168145 AA778650 AI984255 W69468 AA132452 N53166 AI949278 A 168519 F28686 AA908333 F37181 BI002729
TABLE 64C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column are Genbank Idendfier (Gl) numbers "Dunham, et al * refers to the publication endded 'The DNA sequence of human chromosome 22* Dunham, et al (1999) Nature 402489-495
Strand Indicates DNA sfrand from which exons were predicted NLposidon Indicates nudeodde posidons of predicted exons
Pkey Ref Strand Nt position
401781 7249190 Minus 8321583435,83531-83656,8374583901,8423
401780 7249190 Minus 28397-28617,28920-29045,2913529296,2941
401203 9743387 Minus 172961-173056,173868-173928
401785 7249190 Minus 165775165996,166189-166314,16640516656
402294 2282012 Minus 25753000
402845 9369286 Plus 160451-160617,160785161009
403710 6437516 Plus 2741528978
401760 9929699 Plus 8312583250,8532585540,9471595287
403593 6862650 Minus 62554-62712,6944569602
400494 9714719 Plus 169845170272
400835 8954121 Plus 8936589622
401905 8671966 Plus 153965154441,156599-156819
403180 7523976 Minus 6360563759
401747 9789672 Minus 118595118816,119119-119244,119609-11976
403108 8980955 Plus 93253-93667
404996 6007890 Plus 37999-38145,38652-38998,39727-39872,4055
402575 9884830 Minus 109742-109883
402338 6957691 Minus 3691537250
401205 9743388 Plus 167375167433,167935168031
401192 9719502 Minus 69559-70101
406400 9256298 Plus 15551712,18752140,4252-4385,5922-6077
404246 7406725 Plus 82477-82628,82721-82817,82910-83071,8314
401131 8699812 Minus 94802-94987,95804-95887,9632596487,9759
406467 9795551 Plus 182212-182958
403105 8980016 Minus 145287-145744
401429 8217890 Minus 8694587579
402991 7631064 Minus 161294-161579
402956 9408727 Minus 135901-136035
406587 8189273 Minus 120577-120718
402075 8117407 Plus 121907-122035,122804-122921,12401512416
404175 9931117 Minus 107425107547,109625109796 _
TABLE 65A ABOUT 838 GENES DOWNREGULATED IN BENIGN NEVI RELATIVE TO NORMAL SKIN
Table 65A lists about 838 genes downregulated in benign nevi reladve to normal skin Genes were selxted from 59680 probesets on the Eos/Affymetnx Hu03 Genxhip aray Gene expression data for exh probeset obtained from this analysis was expressed as average intensity (Al), a normalized value reflxdng the relative level of mRNA expression Pkey Unique Eos probeset idendfier number
ExAxn Exemplar Axession number, Genbank accession number
UnigenelD Unigene number
Unigene Title Unigene gene title
R1 90th percentile of normal skin Als divided by the average of benign nevi Als
Ft2 90th percentile of normal skin Als divided by the average of benign nevi Als, where the 15th percendle of normal tissue Als was subtracted from both the numerator and denominator
Pkey ExAxn UnigenelD Unigene Tide R1 R2
420813 X51501 Hs 99949 prolxdn-induced protein 27 72 2859
408591 AF015224 Hs 46452 mammaglobin 1 2640 2834
422166 W72424 Hs 112405 S100 calcium-binding protein A9 (calgran 21 33 21 57
418026 BE379727 Hs 83213 fatty xid binding protein 4, adipocyte 1806 1896
429441 AJ224172 Hs 204096 lipophilin B (uteroglobin family member) 1661 1806
428087 AA100573 Hs 182421 troponin C2, fast 1470 1460
407245 X90568 Hs 172004 ddn 1308 1384
428824 W23624 Hs 173059 ESTs 1289 1336
428330 L22524 Hs 2256 matnx metalloproteinase 7 (matnlysin, 1278 1398
444816 Z48633 Hs 283742 H sapiens mRNA for retrotransposon 12 26 986
453309 AI791809 Hs 32949 defensin, beta 1 1202 1062
423024 AA593731 Hs 325823 ESTs, Moderately similar to ALU5_HUMAN A 11 90 1086
446227 AI281459 Hs 270114 ESTs 11 79 1232
413902 AU076743 Hs 75613 CD36 andgen (collagen type I receptor, 11 19 1082
432877 AW974111 Hs 292477 ESTs 11 18 11 30
426752 X69490 Hs 172004 ddn 1097 1263
427899 AA829286 Hs 332053 serum amyloid A1 1085 1385
407230 AA157857 Hs 182265 keratin 19 1079 1140
451029 AA852097 Hs 25829 ras-related protein 1078 1035
421296 NM.0O2666 Hs 103253 penlipin 1073 11 25
431211 M86849 Hs 323733 gap junction protein, beta 2, 26kD (conn 1066 724
422633 X56832 Hs 118804 enolase 3, (beta, muscle) 1057 992
405121 mitogen-xdvated protein kinase 8 inter 1041 1054
450912 AW939251 Hs 25647 v-fos FBJ muπne osteosarcoma viral on∞ 1026 2320
420859 AW468397 Hs 100000 S100 calcium-binding protein A8 (calgran 1025 945
410850 AW362867 Hs 302738 Homo sapiens cDNA FU21425 fis, clone C 10 15 988
416931 D45371 Hs 80485 adipose most abundant gene transcπpt 1 10 13 11 58
447966 AA340605 Hs 105887 ESTs, Weakly similar to Homolog of rat Z 1009 551
401203 Target Exon 995 1074
425545 N98529 Hs 158295 Homo sapiens, clone MGC 12401, mRNA, com 994 11 47
425580 L11144 Hs 1907 galanm 966 660
414092 Z14244 Hs 75752 cytxhrome c oxidase subunit Vllb 945 644
420919 M57892 Hs 100322 carbonic anhydrase VI 941 1049
443162 T49951 Hs 9029 DKFZP434G032 protein 9 36 1058
430154 AW583058 Hs 234726 senne (or cysteine) proteinase inhibito 891 1027
452322 BE566343 Hs 28988 glutaredoxiπ (thioltransferase) 890 26
430071 AA355986 Hs 232068 transcnpdon fxtor 8 (represses inter) 886 894
417240 N57568 Hs 48028 EST 881 1890
415477 NM.002228 Hs 78465 v-jun avian sarcoma virus 17 oncogene ho 8 72 686
430130 AL137311 Hs 234074 Homo sapiens mRNA, cDNA DKFZp761G02121 ( 839 1026
408491 AI088063 Hs 7882 ESTs 800 820
414657 AA424074 Hs 76780 protein phosphatase 1 , regulatory (inhib 799 8 14
409738 BE222975 Hs 56205 insulin induced gene 1 795 775
428221 U96781 Hs 183075 ATPase, Ca transporting, cardix muscle, 789 886
451831 NM 001674 Hs 460 xdvadng transcnpdon fxtor 3 7 79 7 51
410867 X63~556 Hs 750 fibπllin 1 (Marian syndrome) 776 7 55
444984 H15474 Hs 132898 fatty xid desaturase 1 775 564
413076 U10564 Hs 75188 weel (S pombe) homolog 768 565
410532 T53088 Hs 155376 hemoglobin, beta 764 473
442757 AI739528 Hs 28345 ESTs 762 766
412047 AA934589 Hs 49696 ESTs 761 748
410052 AA525225 Hs 334630 Homo sapiens cDNA FU 14462 fis, clone MA 752 728
439394 AA149250 Hs 56105 ESTs 752 672
442941 AU076728 Hs 8867 cysteine-πch, angiogenic inducer, 61 751 627
450680 AF131784 Hs 25318 Homo sapiens clone 25194 mRNA sequence 7 51 4 10
456525 AW468397 Hs 100000 S100 calcium-binding protein A8 (calgran 749 808
407334 AA494411 Hs 296031 ESTs 748 678
414449 AA557660 Hs 76152 dxonn 739 830
432305 M62402 Hs 274313 insulin-like growth fxtor binding prote 738 879
407328 AA508857 ESTs, Weakly similar to ALU1.HUMAN ALU S 735 720
431842 NM 005764 Hs 271473 epithelial protein up-regulated in carci 706 693
426488 X03~350 Hs4 alcohol dehydrogenase 1B (class I), beta 703 785
445502 AW379160 Hs 12813 DKFZP434J214 protein 701 663
419285 D31887 Hs 89868 KIAA0062 protein 701 582
409024 AW883529 Hs 173830 ESTs, Weakly similar to ALU7.HUMAN ALU S 699 458
422963 M79141 Hs 13234 ESTs 699 408
447918 AH 29320 Hs 115175 ESTs, Highly simila to JC5818 gamma-xt 698 649
410530 M25809 Hs64173 ATPase, H transporting, lysosomal (vxuo 696 704
444381 BE387335 Hs 283713 ESTs, Weakly similar to S64054 hypotheti 695 808
417993 AW963705 Hs 301183 molxule possessing ankynn repeats mdu 694 7 12
443060 D78874 Hs8944 prxdlagen C-endopepddase enhancer 2 694 679
427890 AA435761 ESTs 694 668
444207 AI565004 cathepsin D (lysosomal aspartyl protease 693 466
442083 R50192 Hs 165062 ESTs 692 692 441633 AW958544 Hs 112242 normal mucosa of esophagus spxific 1 687 507
407722 BE252241 Hs 38041 pyndoxal (pyπdoxine, vitamin B6) k as 687 499
444051 N48373 Hs 10247 xdvated leucxyte cell adhesion molxu 684 533
414841 H55601 Hs 77490 glutathione S-transferase theta 1 684 347
430314 AA369601 Hs 239138 pre-B-cell colony-enhancing fxtor 679 7 14
427704 AW971063 Hs 292882 ESTs 6 72 730
431713 AK000388 Hs 267997 EHM2 gene 672 7 10
451253 H48299 Hs 26126 claudin 10 6 71 720
453187 AI161383 Hs 34549 ESTs, Highly similar to S94541 1 clone 4 668 302
400304 AF005082 Hs 113261 Homo sapiens skm-spxific protein (xp33 664 608
434625 W01370 Hs 46824 ESTs 661 692
408063 BE086548 Hs 42346 calcineuπn-bmding protein calsarcιn-1 660 729
425280 U31519 Hs 1872 phosphoenolpyr vate carboxykinase 1 (sol 655 679
411388 X72925 Hs 69752 des ocollin 1 655 344
413731 BE243845 Hs 75511 ∞nnxdve dssue growth fxtor 652 486
455863 AA907305 Hs 36475 ESTs 650 4 24
412247 AF022375 Hs 73793 vascula endothelial growth fxtor 649 456
407102 AA007629 glycerol-5phosphate dehydrogenase 1 (so 647 7 23
421407 T82331 Hs 182278 ESTs, Weakly similar to CGHU6C collagen 647 655
406867 AA157857 Hs 182265 keradn 19 644 623
429504 X99133 Hs 204238 lipocalm 2 (oncogene 24p3) (NGAL) 643 679
446945 AI193115 Hs 16611 tumor protein D52-lιke 1 643 566
413172 M38180 Hs 38586 hydroxy-delta-5steroιd dehydrogenase, 3 639 709
407395 AF005082 gb Homo sapiens skin-spxific protein (x 639 476
450626 AW190989 Hs 1508 insulin-degrading enzyme 637 622
450713 AL133611 Hs 25362 Homo sapiens mRNA, cDNA DKFZp4340131 (f 637 491
437596 AA761490 ESTs, Moderately simila to S65657 alpha 635 531
430191 AI149880 Hs 188809 ESTs 634 6 15
433713 A 976511 Hs 112592 ESTs 634 567
420107 AL043980 Hs 7886 pellino (Drosophila) homolog 1 6 33 639
422069 AJ010063 Hs 343603 dtin-cap (telethonin) 633 577
437176 AW176909 Hs 42346 calcineuπn-bindmg protein calsarcιn-1 630 545
433412 AV653729 Hs 8185 CGI-44 protein, sulfide dehydrogenase Ii 629 668
447335 BE617695 Hs 286192 hypothetical protein FU20940 628 1035
413063 AL035737 Hs 75184 chitmase 3-lιke 1 (cartilage glycoprote 6 21 598
440116 AI798851 hemoglobin, gamma G 618 686
454229 AW957744 Hs 278469 Ixπmal proline nch protein 6 17 654
441188 AW292830 Hs 255609 ESTs 6 12 668
451144 AW956103 Hs 61712 pyruvate dehydrogenase kinase, isoeπzyme 6 12 5 79
431319 AA873350 Hs 302232 ESTs 6 11 791
442498 U54617 Hs 8364 Homo sapiens pyruvate dehydrogenase k a 610 563
414555 N98569 Hs 76422 phospholipase A2, group HA (platelets, 608 696
418321 D63477 Hs 84087 KIAA0143 protein 608 471
443072 AI937532 gb wp78d02 x1 NCI_CGAP_Bm25 Homo sapien 607 548
423712 W46802 Hs 81988 disabled (Drosophila) homolog 2 (mitogen 604 581
442679 R53718 hypothedcal protein FU10659 603 567
424824 AI217440 Hs 143873 ESTs 602 546
413719 BE439580 Hs 75498 small inducible cytokine subfamily A (Cy 601 7 05
428358 AA993222 Hs 101915 Stargardt disease 3 (autosomal dominant) 594 7 17
430821 AA487264 Hs 154974 Homo sapiens mRNA, cDNA DKFZp667N064 (fr 592 579
424670 W61215 Hs 116651 epithelial V-like andgen 1 592 563
424673 AA345051 Hs 294092 ESTs, Weakly simila to 138022 hypothed 591 681
418205 L21715 Hs 83760 troponin 1, skeletal, fast 591 695
400440 X83957 Hs 83870 nebulm 589 701
444239 R57988 Hs 10706 epithelial protein lost in neoplasm beta 589 549
419517 AF052107 Hs 90797 Homo sapiens clone 23620 mRNA sequence 586 588
432626 AA471098 Hs 278544 xetyl-Coenzy e A xetyltransferase 2 (a 586 558
407584 W25945 Hs 8173 hypothedcal protein FLJ10803 581 509
449335 AW150717 Hs 345728 STAT induced STAT inhibitor 3 579 633
445607 AA488107 Hs 30156 ESTs, Weakly simila to unnamed protein 578 591
424571 BE379766 polymerase (RNA) II (DNA directed) polyp 578 374
412630 AA738437 Hs 26226 Homo sapiens cDNA FLJ21286 fis, clone C 5 76 4 21
408819 AW163483 Hs 48320 double ππg-finger protein, Dorfin 571 459
433027 AF191018 Hs 279923 putadve nudeodde binding protein, est 570 471
406704 M21665 Hs 929 myosin, heavy polypepdde 7, cardix mus 568 6 12
408515 AI289507 Hs 299883 hypothedcal protein FU23399 567 4 81
443827 AI087867 Hs 134667 ESTs 567 554
429693 BE254962 Hs 211612 SEC24 (S cerevisiae) related gene famil 567 4 12
427373 AB007972 Hs 130760 myosin phosphatase, target subunit 2 566 4 27
428666 AL080190 Hs 189242 Homo sapiens mRNA, cDNA DKFZp434A202 (fr 565 516
421834 BE543205 Hs 288771 DKFZP586A0522 protein 565 452
427081 AI474533 Hs 170528 ESTs, Moderately similar to ALUC.HUMAN ι 565 481
419731 S47242 Hs 92909 SON DNA binding protein 564 377
420787 AA564248 ESTs, Weakly similar to I38022 hypothed 564 327
420682 AI380552 Hs 88602 ESTs 563 4 13
410541 AA065003 Hs 64179 syntenιn-2 protein 562 584
431360 NM 000427 Hs 251680 loncπn 561 514
418127 BE243982 Hs 83532 membrane cofxtor protein (CD46 trophob 561 428
430332 R51790 Hs 239483 Human clone 23933 mRNA sequence 560 576
427850 AA416756 Hs 161051 ESTs, Moderately similar to ALU6.HUMAN A 551 1604
429679 NM.006290 Hs 211600 tumor nxrosis fxtor, alpha-induced pro 549 5 28
422082 AA016188 Hs 111244 hypothedcal protein 549 523
419461 AI452601 Hs 288869 nuclear receptor subfamily 2, group F, m 549 4 40 430714 AA484757 Hs 287601 Homo sapiens cDNA FU13830 fis, clone TH 548 538
407744 AB020629 Hs 38095 ATP-bindmg cassette, sub-family A (ABC1 546 5 11
400494 ENSP00000238970* CIG30 (Fragment) 545 363
415062 H45100 Hs 49753 uveal autoandgen with coiled coil doma 543 425
449291 BE176893 Hs 23440 KIAA1105 protein 541 382
435538 AB011540 Hs4930 low density lipoprotein receptor-related 541 262
417035 AA192455 Hs 22968 Homo sapiens clone IMAGE 451939, mRNA se 540 540
434535 AI611729 Hs 167619 ESTs, Moderately similar to ALUC.HUMAN " 540 5 20
408085 N25929 Hs 342849 ADP-πbosyladon fxtor-like 5 539 4 59
413778 AA090235 Hs 75535 myosin, light polypepdde 2, regulatory, 537 1496
436090 AI640635 Hs 332879 EST 537 533
406805 AI686003 Hs 296031 ESTs 535 549
426510 AW861225 Hs 251928 BANP homolog, SMAR1 homolog 535 683
406706 X03740 Hs 231581 myosin, heavy polypepdde 1, skeletal mu 534 750
456332 AA228357 gb nc39d05 r1 NCI_CGAP_Pr2 Homo sapiens 534 488
421999 U50535 Hs 110630 Human BRCA2 region, mRNA sequence CG006 534 475
418479 AA829976 mannosidase, alpha, class 1A, member 2 534 359
417059 AL037672 Hs 81071 extrxellula matnx protein 1 534 4 71
424008 R02740 Hs 137555 putadve chemokine receptor, GTP-binding 534 475
415694 AW194301 Hs 339283 Human DNA sequence from clone RP1-187J11 534 869
452747 BE153855 Hs 61460 Ig superfamily rxeptor LNIR 531 581
449271 AW338067 Hs 7869 Homo sapiens cDNA FU11946 fis, clone HE 530 435
437135 AL038624 Hs 208752 ESTs, Weakly similar to ALU8.HUMAN ALU S 529 492
419925 AA159850 Hs 93765 lipoma HMGIC fusion partner 529 502
415192 D17793 Hs 78183 aldo-keto reductase family 1 , member C3 528 533
453999 BE328153 Hs 240087 ESTs 528 340
408958 T99607 Hs 49346 signal recognition particle 54kD 528 284
452496 AA114926 Hs 169531 ESTs 5 28 548
424058 AL121516 Hs 138617 thyroid hormone receptor interxtor 12 527 372
443265 AI916207 Hs 9167 SH3 domain binding glutamic xid-πch pr 526 462
407013 U35637 Hs 83870 gb Human nebulin mRNA, partial eds 5 26 6 21
414602 AW630O88 Hs 76550 Homo sapiens mRNA, cDNA DKFZp564B1264 (f 526 4 21
410284 U50939 Hs 61828 amyloid beta precursor protein-binding p 526 443
445107 AI208121 Hs 147313 ESTs, Weakly similar to I38022 hypothed 5 25 561
446267 AW450103 Hs 151124 ESTs 524 444
422278 AF072873 Hs 114218 frizzled (Drosophila) homolog 6 5 23 3 14
448585 AB020676 Hs 21543 KIAA0869 protein 523 6 21
421993 R22497 Hs 110571 growth arrest and DNA-damage-inducible, 522 684
414407 AA147026 Hs 76704 ESTs 5 22 529
423720 AL044191 Hs 23388 hypothedcal protein DKFZp434F0318 522 585
415997 NM.003590 Hs 78946 cullin 3 521 366
411531 AB014511 Hs 70604 ATPase, Class II, type 9A 521 395
441619 NM.014056 HS 7917 DKFZP564K247 protein 520 438
435232 NM 001262 Hs 854 cyclin-dependent kinase inhibitor 2C (p1 5 19 452
415167 AA160784 Hs 26410 ESTs 519 3 13
431416 AA532718 Hs 178604 ESTs 518 538
439995 AL137480 Hs 6834 KIAA1014 protein 517 3 14
416784 AA334592 Hs 79914 lumican 5 17 6 18
446082 AI274139 Hs 156452 ESTs 5 16 5 14
400196 Eos Control 516 505
414525 C14904 Hs 45184 Homo sapiens cDNA FU12284 fis, clone MA 5 16 431
414242 AA749230 Hs 26433 dolιchyl-phosphate (UDP-N-xetylglucosam 515 4 89
430699 AW969847 Hs 292718 ESTs, Weakly simila to RET2 HUMAN RETIN 514 522
440383 AA884208 Hs 30484 ESTs 5 13 509
431628 AF146277 CD2-assxιated protein 513 503
407047 X65965 gb H sapiens SOD-2 gene for manganese su 5 13 431
433688 AA628467 Hs 112572 Homo sapiens cDNA FU14130 fis, clone MA 512 357
437704 AA766142 Hs 131810 ESTs. Moderately similar to ALU1.HUMAN A 5 12 330
426101 AL049987 Homo sapiens mRNA, cDNA DKFZp564F112 (fr 511 608
428297 AA236291 Hs 183583 senne (or cysteine) proteinase inhibito 5 10 431
416382 D86985 Hs 79276 KIAA0232gene product 5 10 379
437150 R51407 Hs 77910 3-hydroxy-5methylglutaryl-Coenzyme A sy 5 10 658
454947 AW846590 gb QV5CT0180-011099-025d07 CT0180 Homo 509 482
434647 W74158 Hs 103189 lipopolysaxhaπde spxific respoπse-68 509 490
418730 AA091027 Hs 325625 Homo sapiens clone 23938 mRNA sequence 509 346
449338 H73444 Hs 394 adrenomedullin 509 626
438962 BE046594 gb hn41d 1 x1 NCI.CGAP.RDF2 Homo sapiens 508 560
431693 AI459519 senne (or cysteine) proteinase inhibito 507 283
420583 H77859 Hs 65450 redculon 4 506 671
431048 R50253 Hs 249129 cell death-inducing DFFA-like effector a 506 606
432125 AW972667 Hs 183006 Homo sapiens cDNA FU12300 fis, clone MA 505 632
447945 AI922838 Hs 9670 ESTs, Weakly similar to ALU1 HUMAN ALU S 505 3 72
442547 AA306997 Hs 217484 ESTs, Weakly similar to ALU1.HUMAN ALU S 505 286
414176 BE140638 Hs 75794 EDG-2 (endothelial differendadon, lys 503 443
445263 H57646 Hs 42586 KIAA1560 protein 503 667
448490 AI523897 Hs 271692 ESTs, Weakly similar to I38022 hypothed 503 488
450515 AW304226 biphenyl hydrolase-like (senne hydrolas 503 436
440624 AF017987 Hs 7306 sxreted frizzled-related protein 1 501 548
417165 R80137 Hs 302738 Homo sapiens cONA FU21425 fis, clone C 501 561
417640 030857 Hs 82353 protein C receptor, endothelial (EPCR) 501 532
413475 AW021488 Hs 26981 ESTs 501 390
414792 BE314949 Hs 87128 hypothedcal protein FU23309 500 454
424074 AI902456 Hs 210761 ESTs, Weakly simila to I38022 hypothed 500 3 19 424620 AA101043 Hs 151254 kallikrein 7 (chymotrγpdc, stratum com 499 625
439039 AI656707 Hs 48713 ESTs 499 660
422305 AI928242 Hs 293438 ESTs Highly similar to AF198488 1 trans 498 9 59
410579 AK001628 Hs 64691 KIAA0483 protein 498 4 52
449710 AA002207 Hs 17385 Homo sapiens clone IMAGE 119716, mRNA se 498 384
434230 AA551569 hypothetical protein PR02822 498 363
426468 AA379306 Hs 117558 ESTs 498 356
421690 AW162667 Hs 106857 calbindm 2, (29kD, calretinin) 496 641
448144 AW169230 ESTs, Moderately similar to PC4259 fem 496 328
412129 M21984 Hs 73454 troponin T3, skeletal, fast 496 575
450071 AA018283 Hs 24359 Homo sapiens cDNA FU11174 fis, clone PL 496 321
433934 AW273261 Hs 216292 ESTs 495 439
446320 AF126245 Hs 14791 xyl-Coenzyme A dehydrogenase family, me 495 401
446161 AA628206 Hs 14125 p53 regulated PA26 nuclea protein 494 4 54
453225 BE258769 acetyl-Coenzyme A xyltransferase 2 (mit 494 449
444476 AF020038 Hs 11223 isxitrate dehydrogenase 1 (NAOP), solub 494 4 19
445493 AI915771 metallothionein 1E (funcdonal) 493 568
422292 AI815733 Hs 114360 transforming growth fxtor beta-sdmulat 493 547
417054 AF017060 aldehyde oxidase 1 493 451
425917 W28517 Hs 117167 Homo sapiens cONA FU23067 fis, clone L 493 334
408681 AW953853 Hs 281462 ESTs, Weakly similar to I38022 hypothed 493 561
451267 AI033894 Hs 117865 solute earner family 17 (amon/suga tr 492 327
447137 AW970192 Hs 171942 ras responsive element binding protein 1 491 426
427451 AI690916 Hs 178137 transducer of ERBB2, 1 490 600
432314 AA533447 Hs 312989 ESTs 490 379
440692 AL031591 Hs 7370 phosphoddylmositol transfer protein, b 489 371
428594 BE387236 Hs 75415 beta-2-mιcroglobulιn 489 327
437802 AI475995 Hs 122910 ESTs 487 406
437974 T74445 Hs 5957 Homo sapiens done 24416 mRNA sequence 486 654
427156 BE621719 Hs 173802 KIAA0603 gene product 486 5 15
433179 AW362945 Hs 162459 ESTs 486 550
428957 NM.003881 Hs 194679 WNT1 inducible signaling pathway protein 485 5 29
453855 AA039576 Hs 37858 ESTs, Weakly simila to ALUB.HUMAN »" 485 3 59
433143 BE552155 Hs 294035 ESTs, Weakly similar to ALU5 HUMAN ALU S 485 345
429279 AB018271 Hs 198689 KIAA0728 protein 4 83 380
445773 H73456 Hs 13299 Homo sapiens mRNA, cDNA DKFZp761 M0111 (f 482 420
416349 X69089 Hs 79227 myomesin (M-protein) 2 (165kD) 482 401
408138 AA535740 tumor protein p53-bιndιng protein, 1 4 81 4 19
432566 AW439330 Hs 256889 ESTs, Weakly similar to 2109260A B cell 480 399
444677 AL110212 Hs 301005 punne-πch element binding protein B 480 3 50
422658 AF231981 Hs 250175 homolog of yeast long chain polyunsatura 480 1020
431926 AW972724 gb EST384816 MAGE resequences, MAGL Homo 4 79 439
407839 AA045144 Hs 161566 ESTs 479 298
421998 R74441 poly(A)-bιndιng protein, nuclea 1 4 77 478
416987 D86957 Hs 80712 KIAA0202 protein 476 399
448988 Y09763 Hs 22785 gamma-aminobutync xid (GABA) A recepto 476 759
440494 BE618768 Hs 7232 acetyl-Coenzyme A carboxylase alpha 4 75 438
453180 N46243 Hs 110373 ESTs, Highly similar to T42626 sxreted 475 392
413276 Z24725 Hs 75260 mitogen inducible 2 475 568
437239 AW503395 Hs 5541 ATPase, Ca transporting, ubiquitous 474 557
414622 AI752666 Hs 76669 nicodnamide N-methyltransferase 474 11 58
429587 AA283969 Hs 334706 Homo sapiens cDNA FLJ11801 fis, clone HE 4 74 379
407242 M18728 gb Human nonspxific crossrexdng andg 473 488
445229 BE276013 Hs 172364 Homo sapiens mRNA for FU00086 protein. 4 73 479
447429 AB007920 Hs 18586 KIAA0451 gene product 472 238
444930 BE185536 Hs 301183 molxule possessing ankyπn repeats indu 471 5 10
414848 AI803447 Hs 77496 small nuclea nbonucleoprotein polypept 471 251
439652 W67826 Hs 55412 ESTs, Weakly similar to K1 CJ.HUMAN KERAT 470 6 13
453145 R63438 Hs 183454 Homo sapiens cDNA FU14883 fis, ctone PL 470 306
421302 T34462 Hs 103291 neundπ 469 496
425118 AU076611 Hs 154672 methylene tetrahydrofolate dehydrogenase 468 501
448079 R76981 thyroid hormone rxeptor assxiated prot 468 397
434558 AW264102 Hs 39168 ESTs 467 342
408239 AA053401 ESTs, Moderately similar to ALU7 HUMAN A 467 6 17
454416 AI912097 Hs 163208 ESTs 466 397
427215 AW246148 Hs 268371 hypothetical protein FLJ20274 4 66 3 37
451583 AI653797 Hs 24133 ESTs 465 381
446525 AW967069 Hs 211556 hypothetical protein MGC5487 465 6 14
436176 AL121422 Hs 54900 serologically defined colon cancer andg 465 365
450528 NM 014072 Hs 25063 PRO0461 protein 464 299
417259 AW903838 Hs 81800 chondroidn sulfate proteoglycan 2 (vers 464 4 72
408741 M73720 Hs 646 carboxypepddase A3 (mast cell) 463 555
417733 AL048678 Hs 82503 H sapiens mRNA for 3'UTR of unknown prot 463 504
436280 AI690734 Homo sapiens cDNA FU22562 fis clone H 463 355
428744 BE267033 Hs 192853 ubiquitin-conjugatmg enzyme E2G 2 (homo 463 285
427007 NM.006283 Hs 173159 transforming, acidic coiled-coil contain 463 300
453767 AB011792 Hs 35094 extrxellular matπx protein 2, female o 4 62 5 14
449971 AA807346 Hs 288581 Homo sapiens cDNA FLJ14296 fis, clone PL 462 449
409598 NM 014018 Hs 55097 mitxhondπal πbosomal protein S28 462 356
413305 NM 000426 Hs 323511 Homo sapiens cDNA FU23176 fis, clone L 462 4 24
412577 Z22968 Hs 74076 CD163 andgen 461 803
424046 AF027866 Hs 138202 senne (or cysteine) proteinase inhibito 4 61 686
452289 BE568205 Hs 28827 mitogen-xdvated protein kinase kinase 461 4 33 458971 AU 19206 Hs 101874 ESTs, Weakly similar to ALU1.HUMAN ALU S 461 4 16
433256 AW604447 Hs 339408 ESTs, Weakly similar to S26689 hypothed 461 358
440596 H13032 Hs 103378 hypothedcal protein MGC11034 461 322
427919 AA173942 Hs 326416 Homo sapiens mRNA, cDNA DKFZp564H1916 (f 460 4 74
424651 AI493206 Hs 32425 ESTs 460 411
436701 AW959032 ESTs, Moderately simila to I78885 serin 460 234
413691 AB023173 Hs 75478 ATPase, Class VI, type 11B 459 4 36
448625 AW970786 Hs 178470 hypothedcal protein FU22662 59 400
436283 AI480319 Hs 120058 ESTs 459 376
451710 AW867467 Hs 278712 eukaryodc translation initiation fxtor 4 59 351
436086 Z43133 Hs 9961 Homo sapiens cDNA FU21954 fis, clone H 459 364
434697 AL133033 Hs 4084 KIAA1025 protein 458 510
402294 Target Exon 457 547
424098 AF077374 Hs 139322 small proline-πch protein 3 457 512
406648 AA563730 Hs 277477 major histocompadbility complex, class 457 466
428423 AU076517 Hs 184276 solute earner family 9 (sodium/hydrogen 457 415
441566 AA604110 Hs 151725 ESTs 457 321
400109 Ex Control 456 476
419740 AB037835 Hs 92991 KIAA1414 protein 456 363
421481 AW391972 Hs 104696 KIAA1324 protein 455 7 16
440266 AA088809 Hs 19525 hypothedcal protein FU22794 455 444
421979 AW062518 Hs 233150 hypothedcal protein MGC5560 455 436
408702 AW959893 Hs 27099 hypothedcal protein FU23293 similar to 454 578
418021 M15881 Hs 1137 uromodulin (uromucαd, Tamm-Horsfall gly 454 461
422068 AI807519 Hs 104520 Homo sapiens cDNA FU13694 (is, clone PL 454 432
421986 AL137438 Hs 110454 SEC15 (S cerevιsιae)-lιke 454 259
414798 AI286323 Hs 97411 hypothedcal protein MGC12335 453 6 18
410132 NM 003480 Hs 300946 Microfibπl-assxiated glycoprotein-2 453 587
449843 R85337 Hs 24030 solute earner family 31 (copper transpo 453 487
424399 AI905687 AI905687 IL-BT095190199-019 BT095 Homo 453 1061
452924 AW580939 Hs 97199 complement component C1q rxeptor 451 607
454000 AA040620 Hs 5672 hypothedcal protein AF140225 451 459
404730 Target Exon 451 430
449943 AF104266 Hs 24212 latrophidn 451 340
414217 AI309298 Hs 279898 Homo sapiens cDNA FU23165 fis, clone L 450 297
435992 AI033259 Hs 118317 Homo sapiens cDNA FU12088 fis, clone HE 450 477
421311 N71848 Hs 283609 hypothedcal protein PRO2032 450 330
449785 AI225235 Hs 288300 hypothetical protein FU 23231 449 506
437611 AA897108 gb am08a06 s1 Soaes NFL T GBC S1 Homo s 449 4 24
419612 AI498267 Hs 110613 KIAA0421 protein 449 416
414496 W73853 ESTs 449 3 15
450306 AL080080 Hs 24766 thioredoxin doman-contanmg 448 338
444895 AI674383 Hs 22891 solute earner family 7 (cationic ammo 447 445
432559 AW452948 Hs 257631 ESTs 447 539
442554 AW467376 Hs 129640 ESTs 447 400
421429 NM 014922 Hs 104305 death effector filament-forming Ced-4-lι 446 447
422313 AF045941 Hs 115166 sciellin 445 507
435748 AA699756 Hs 117335 ESTs 445 335
453283 AA694386 Hs 290914 ESTs 445 328
441925 R83113 protein kinase C substrate 80K-H 445 3 28
440030 AA932693 EST 445 320
446515 AL048875 hypothetical protein DKFZp566l133 444 366
406707 S73840 Hs 931 myosin, heavy polypepdde 2, skeletal mu 444 590
432341 AL137662 Hs 274401 Homo sapiens mRNA, cDNA DKFZp434P086 (fr 444 399
410453 AW749036 gb RC2-BT0315241195011-f10 BT0318 Homo 444 349
450196 AW956868 Hs 24608 DKFZP564D177 protein 443 4 13
444147 ABOO2306 Hs 10351 KIAA0308 protein 443 395
427809 M26380 Hs 180878 lipoprotein lipase 442 388
428157 AI738719 Hs 198427 hexokmase 2 442 546
413299 AA857487 Hs 75275 ubiquitination fxtor E4A (homologous to 442 377
440245 AK001913 Hs 7100 hypothedcal protein 442 351
442379 NM 004613 Hs 8265 transglutaminase 2 (C polypepdde, prote 442 1 79
408569 BE066047 Hs 86412 chromosome 9 open reading frame 5 442 335
430361 AI033965 Hs 239926 sterol-C4-methyl oxidase-like 441 578
414489 AI620677 Hs 73105 ESTs 441 543
447731 AA373527 Hs 19385 CGI-58 protein 441 5 28
443195 BE148235 Hs 193063 Homo sapiens cDNA FU14201 fis, ctone NT 441 441
448503 BE243146 Hs 21332 BTB (POZ) domain contaning 1 441 368
432546 BE618778 Hs 180638 hypothedcal protein FLJ 13081 441 355
445620 AI245225 Hs 17441 ESTs 441 344
454065 BE394588 gb 601311808F1 NIH.MGC.44 Homo sapiens c 441 343
418802 AB028989 Hs 88500 mitogen-xdvated protein kinase 8 inter 440 204
431816 T87431 Hs 190738 ESTs 439 4 26
429138 AB020657 Hs 197298 NSl-bmding protein 4 39 447
426643 AA857131 Hs 171595 HIV TAT spxific fxtor 1 439 309
448943 AI608810 Hs 193288 ESTs 439 263
414002 NM.006732 Hs 75678 FBJ muπne osteosacoma viral oncogene h 437 19 16
403593 Target Exon 437 635
408104 AW972927 Hs 293968 ESTs 431 582
429624 AA458648 Hs 99476 ESTs, Weakly similar to 13131848 atphal 4 31 4 14
429538 BE182592 Hs 139322 small prolme-πch protem 2A 425 661
414505 R45389 Hs 23558 ESTs, Weakly similar to A48042 lysosomal 4 18 528
438533 AI440266 Hs 170673 ESTs, Weakly similar to T24832 hypothed 418 581 426143 BE379836 proteasome (prosome mxropan) subunit 4 15 5 12
414527 BE241739 Hs 76359 catalase 14 5 13
422287 F16365 Hs 114346 cytxhrome c oxidase subunit Vila polype 4 13 860
408199 AA132637 Hs 15396 Homo sapiens, clone IMAGE 3948909, mRNA 4 12 594
412477 AA150864 microsomal glutathione S-transferase 1 4 10 1000
411558 AA102670 Hs 70725 gamma-aminobutync xid (GABA) A recepto 4 09 539
444252 R21135 Hs 54985 ESTs 407 601
400295 W72838 AI905687 IL-BT095190195019 BT095 Homo 406 1332
438746 AI885815 Hs 184727 Human melanoma-assxiated andgen p97 ( 406 757
429856 AA971576 Hs 225951 topoisomerase-related funcdon protein 4 405 6 24
422168 AA586894 Hs 112408 S100 calcium-binding protein A7 (psoπas 401 461
403710 C4000160 gι|12735793|ref]XP_011928 1| pr 400 406
406643 N77976 Hs 347939 hemoglobin, alpha 2 397 7 22
436372 AW972301 Hs 310286 ESTs 396 541
428340 AF261088 Hs 154721 acomtase l, soluble 394 533
424604 AW865388 Hs 151076 KIAA1243 protein 391 759
426653 AA530892 Hs 171695 dual specificity phosphatase 1 391 1481
410204 AJ243425 Hs 326035 early growth response 1 387 996
448520 AB002367 Hs 21355 doublecortin and CaM kinase-like 1 387 509
443021 AA368546 Hs 8904 Ig superfamily protein 386 765
430418 R98852 Hs 36029 heart and neural crest denvadves expre 381 619
447796 AW953622 Hs 223025 RAB31, member RAS oncogene family 376 510
419407 AW410377 Hs 41502 hypothedcal protein FU21276 376 512
443725 AW245680 Hs 9701 growth arrest and DNA-damage-inducible, 375 546
426281 AK0OO987 Hs 169111 oxidadon resistance 1 374 5 14
423973 AF038461 Hs 136574 arxhidonate 12-lιpoxygenase, 12Rtype 374 630
445234 AW137636 Hs 146059 ESTs 372 559
457411 AW085961 Hs 130093 iroquois-dass homeobox protein IRX2 3 71 485
456063 NM 006744 Hs 76461 retiπol-binding protein 4, interstitial 3 71 6 72
413880 AI660842 Hs 110915 interieukin 22 rxeptor 371 401
422640 M37984 Hs 118845 troponin C, slow. 371 9 10
452241 AL050204 Hs 28540 Homo sapiens mRNA cDNA DKFZp586F1223 (f 370 321
453560 AA348626 Hs 5890 hypothetical protein FU23306 369 5 13
410197 NM.005518 Hs 59889 5hydroxy-5methylglutaryl-Coenzyme A sy 369 769
413922 AI535895 Hs 221024 ESTs 368 4 80
428698 AA852773 Hs 334838 KIAA1866 protein 364 522
451951 AW082870 Hs 210954 ESTs 364 369
452308 AI167560 Hs 61297 ESTs 364 435
441128 AA570256 ESTs, Weakly similar to T23273 hypothed 363 291
421978 AJ243662 Hs 110196 NICE-1 protein 361 605
418533 NM 004533 Hs 85937 myosin binding protein C fast-type 361 6 22
452413 AW082633 Hs 215030 ESTs 358 303
453003 AA808466 Hs 103395 hypothetical protein FU14146 355 6 39
408522 AI541214 Hs 46320 Small prolme-πch protein SPRK [human, 354 1068
423503 M92843 Hs 343586 zinc finger protein homologous to Zfp-36 353 15 11
419879 Z17805 Hs 93564 Homer, neuronal immediate early gene, 2 353 529
428382 AF007132 Hs 184019 Homo sapiens clone 23551 mRNA sequence 351 446
447165 AL042400 Hs 75668 Homo sapiens, Similar to RIKEN cDNA 1700 351 367
418067 AI127958 Hs 83393 cystadn E/M 351 374
420202 AL036557 Hs 95910 putadve lymphxyte G0/G1 switch gene 350 1464
432543 AA552690 Hs 152423 Homo sapiens cDNA FU21274 fis, clone C 350 279
442321 AF207664 Hs 8230 a dismtegnn-like and metatloprotease ( 348 791
450860 AA021007 integnn, beta 8 347 589
414665 AA160873 serum amyloid A1 346 9 22
413663 BE247585 Hs 75462 BTG family, member 2 346 563
427408 AA583206 Hs 2156 RAR related orphan rxeptor A 345 308
430171 AF086289 Hs 234766 skm-spxific protein 345 477
453655 AW960427 Hs 342874 transforming growth fxtor, beta rxepto 342 809
450607 AL050373 Hs 25213 hypothetical protein 341 643
412596 AA161219 Hs 799 diphtheπa toxin rxeptor (hepaπn-bmdi 341 610
427681 AB018263 Hs 180338 tumor nxrosis fxtor rxeptor superfami 339 659
440590 AI863446 Hs 266308 mosac senne protease 334 309
452669 AA216363 Hs 262958 hypothetical protein DKFZp434B044 331 1006
422101 AW404176 Hs 111611 πbosomal protein L27 330 393
431986 AA536130 Hs 149018 Novel human gene mapping to chomosome 20 330 354
412649 NM 002206 Hs 74369 integnn, alpha 7 3 28 689
423017 AW178761 Hs 227948 senne (or cysteine) proteinase inhibito 328 544
425163 D10040 Hs 154890 fatty-xid-Coenzyme A ligase, long-chain 328 593
412061 AA833763 Hs 330211 ESTs 327 575
437592 NM 003851 Hs 5710 cellular repressor of EIA-stimulated gen 3 27 583
452849 AF044924 Hs 30792 hook2 protein 326 566
421462 AF016495 Hs 104624 aquapoπn 9 325 498
422083 NM 001141 Hs 111256 axhidonate 15lιpoxygenase, sxond typ 24 656
444935 AA262449 Hs 223569 ESTs 3 24 596
422057 AI205785 Hs 30348 ESTs 322 5 72
410017 AW952426 Hs 109438 Homo sapiens clone 24775 mRNA sequence 321 526
407948 AW085161 Hs 56279 ICEBERG caspase-1 inhibitor 3 21 461
452089 T97294 Hs 271492 ESTs, Weakly similar to PC4211 hepatocel 3 19 4 42
448249 AW855331 Hs 337124 ESTs 3 18 297
430869 D10511 Hs 37 xetyl-Coenzyme A xetyltransferase 1 (a 317 566
443623 AA345519 Hs 9641 complement component 1, q subcomponent, 3 16 1200
452865 AI924046 Hs 119567 ESTs, Weakly similar to A47582 B-cell gr 3 16 603
452392 L20815 Hs 507 comeodesmosin 3 15 570 410231 AA314163 HS 61153 proteasome (prosome, mxropan) 26S subu 3 15 587
420309 AW043637 Hs 21766 ESTs, Weakly similar to ALU5.HUMAN ALU S 315 498
406791 AI220684 Hs 347939 hemoglobin, alpha 2 313 17 37
419648 T73661 Hs 91877 thyroid hormone responsive SP0T14 (rat) 312 463
421485 AA243499 Hs 104800 hypothetical protein FU10134 3 12 302
432375 BE536069 Hs 2962 S100 calcium-binding protein P 3 12 851
417713 042047 Hs 82432 KIAA0089 protein 312 582
446948 BE409053 Hs 299629 peroxisomal long-chain acyl-coA thioeste 3 11 651
444195 AB002351 Hs 10587 KIAA0353 protein 311 544
415704 NM.001677 Hs 78629 ATPase, Na9 transporting, beta 1 polypep 311 661
401905 ENSP00000252232* Sterol regulatory eleme 310 352
443071 AL080021 Hs 8986 ∞mplement ∞mponent 1, q subcomponent 310 5 10
427095 AA316080 Hs 173554 ubiquinol-cytochrome c redudase core pr 310 539
413835 AI272727 Hs 249163 fatty xid hydroxylase 308 556
448106 AI800470 Hs 171941 ESTs 307 5 19
432908 AI861896 ESTs 307 347
422158 L10343 Hs 112341 protease inhibitor 3, skin-deπved (SKAL 307 748
429506 D49835 Hs 171942 ras responsive element binding protein 1 305 397
424998 U58515 Hs 154138 chidnase 3-lιke 2 302 675
419358 T78763 Hs 90063 neurxalcm delta 300 768
414541 BE293116 Hs 76392 aldehyde dehydrogenase 1 family, member 299 544
426402 BE387327 Hs 80475 polymerase (RNA) II (DNA dirxted) polyp 299 684
450472 AI190071 Hs 55278 ESTs 298 506
421335 X99977 Hs 103505 ARS ∞mponent B 297 9 31
431316 AA502663 Hs 145037 ESTs 296 430
420996 AK001927 Hs 100895 hypothetical protein FU10462 296 297
451176 AA046457 Hs 60677 ESTs 295 6 59
444204 AI129194 Hs 143040 ESTs 293 392
436723 AW975895 Hs 307486 ESTs 293 664
436664 AW197887 Hs 253353 ESTs 293 3 82
406962 M13485 gb Human metallothionem l-B gene, exon 293 3 10
453092 X64838 Hs 31638 resdn (Reed-Steinberg cell-expressed in 293 535
444734 NM 001360 Hs 11806 7-dehydrxholesterol reductase 291 984
430310 U60115 Hs 239069 four and a half LIM domans 1 291 702
420876 AA918425 Hs 177744 ESTs 291 541
426050 AF017307 Hs 166096 E74-lιke fxtor 3 (ets doman franscnpt 291 564
428232 BE272452 Hs 183109 monoamine oxidase A 290 954
413796 AW408094 Hs 75545 interieukin 4 rxeptor 289 537
413884 AI668892 Hs 239758 hypothetical protein FU 12389 similar to 288 534
411372 AI147861 Hs 213289 low density lipoprotein receptor (famili 286 6 31
428500 AI815395 Hs 184641 fatty xid desaturase 2 286 393
444135 AK000374 Hs 10346 hypothedcal protein FU20154 286 605
452689 F33868 Hs 284176 transfemn 285 6 11
403108 ENSP00000241415* Hypothedcal 677 kDa p 285 3 17
434433 AW629759 gb hh70e05 y1 NCI.CGAP.GU1 Homo sapiens 284 335
434952 T10269 Hs 4285 Homo sapiens cDNA FU22505 fis, clone H 283 405
420544 AA677577 Hs 98732 Homo sapiens Chromosome 16 BAC clone CIT 283 3 57
406922 S70284 Hs 119597 gb steaoyl-CoA desaturase [human, adipo 282 380
437470 AL390147 Hs 134742 hypothetical protein DKFZp547D065 282 640
429807 AKO02138 Hs 306227 Homo sapiens cDNA FLJ11276 fis, done PL 282 297
425180 U00115 Hs 155024 B-cell CLUIymphoma 6 (zinc finger prote 281 5 15
415409 AW993701 NS1-assxιated protein 1 280 6 16
433848 AF095719 Hs 93764 carboxypepddase A4 280 288
425750 AL050276 Hs 42400 zinc finger protein 288 279 599
433638 AW872507 Hs 3462 cytxhrome c oxidase subunit Vile 2 78 525
429128 AA446869 Hs 119316 ESTs 278 4 17
446292 AF081497 Hs 279682 Fth type C glycoprotein 277 7 37
430420 AW140027 Hs 26373 Homo sapiens cDNA FU23449 fis, clone H 276 609
419923 AW081455 Hs 120219 ESTs 276 4 31
407555 Z48511 gb H sapiens XG mRNA (clone PEP11) 276 4 12
425240 AA306495 Hs 1869 phosphoglucomutase 1 274 592
459317 BRCAIb Eos Control 274 1985
425819 N92165 Hs 93231 ESTs 274 572
408839 AW277084 gb xp61h09 x1 NCI_CGAP_0v39 Homo sapiens 273 393
418253 AA215539 Hs 283643 Homo sapiens cDNA FLJ11606 fis, clone HE 272 594
409453 AI885516 Hs 95612 ESTs 272 6 51
406625 Y13647 Hs 119597 stearoyl-CoA desaturase (delta-9-desatur 272 380
420074 AA253425 Hs 190074 ESTs 271 404
429547 AW009166 Hs 99376 FGENESH predicted novel sxreted protein 271 284
444026 AA205759 Hs 10119 hypothedcal protein FU 14957 271 6 17
407112 AA070801 Hs 51615 ESTs, Weakly similar to ALU7.HUMAN ALU S 270 523
429615 AF258627 Hs 211562 ATP-bmding cassette, sub-family A (ABC1 269 533
419098 AA234041 Hs 87271 ESTs 269 322
424206 NM 003734 Hs 198241 amine oxidase, copper containing 3 (vase 269 664
443102 AI247472 Hs 132965 ESTs 268 585
411939 AI365585 Hs 146246 ESTs 268 538
453201 AI432195 Hs 135098 ESTs 268 369
420231 R06866 Hs 19813 ESTs 267 4 70
404996 Taiget Exon 267 497
452955 AW390282 Hs 31130 transmembrane 7 superfamily member 2 266 6 36
447205 BE617015 Hs 11006 ESTs. Moderately similar to T17372 plasm 265 1565
417365 D50683 Hs 82028 transforming growth fxtor, beta recepto 265 7 74
444169 AV648170 Hs 58756 ESTs 264 340 431247 AL021578 Hs 278489 atnlm 4 264 335
423960 AA164516 Hs 136309 SH5contaιnmg protein SH3GLB1 263 5 12
432093 H28383 gb yl52c03 r1 Soares breast 3NbHBst Homo 263 408
408669 AI493591 Hs 78146 platelet/endothedal cell adhesion molx 261 644
440924 AF151872 Hs 7527 small fragment nuclease 2 59 6 37
416232 AW502678 Hs 79090 exportin 1 (CR 1, yeast, homolog) 259 646
425320 U29344 Hs 83190 fatty xid synthase 2.59 393
402315 NM 003430 Homo sapiens zinc finger prote 258 609
449539 W80363 Hs 58446 ESTs 258 405
418271 NM 000919 Hs 83920 peptidylglycine alpha-amidadng onooxyg 258 561
449967 R40978 Hs 271498 ESTs, Moderately similar to ALU1 HUMAN A 258 354
438752 AW238673 Hs 146038 ESTs 258 5 24
424675 NM 005512 Hs 151641 glycoprotein A repeddons predominant 257 516
438763 AI583207 Hs 99029 CCAAT/enhancer binding protein (C/EBP), 257 645
413630 AL036883 Hs 75450 delta sleep inducing pepdde, immunoreac 256 638
424834 AK0O1432 Hs 153408 Homo sapiens cONA FU10570 fis, clone NT 256 290
427666 AI791495 Hs 180142 calmodulm-like skin protein (CLSP) 256 267
426403 NM 000361 Hs 2030 thrombomodulin 256 519
432906 BE265489 Hs 3123 . lethal giant larvae (Drosophila) homolog 255 562
420924 R01026 Hs 245321 ESTs 255 322
427527 AI809057 Hs 153261 immunoglobulin heavy constant mu 2 55 545
407083 Z48511 H sapiens XG mRNA (clone PEP11) 255 450
445437 AI224165 Hs 148725 ESTs 2.54 472
425097 NM 014247 PDZ domain containing guanine nudeodde 254 528
420105 AW015571 Hs 32244 ESTs, Weakly similar to FMOD.HUMAN FIBRO 253 6 55
429554 NM 012275 Hs 207224 interieukin 1, delta 253 284
408896 AI610447 Hs 48778 niban protein 253 708
409169 F00991 Hs 50889 (clone PWHLC2-24) myosin light chan 2 2 52 868
420235 AA256756 Hs 31178 ESTs 251 421
436314 AI983409 ESTs 251 3 11
440602 AI743491 Hs 292692 ESTs 250 271
444946 AW139205 Hs 156457 hypothedcal protein FU22408 248 286
430235 BE268048 Hs 236494 FΪAB10, member RAS oncogene family 248 537
423929 M69136 Hs 135626 chyrnase l, mast cell 248 3 21
426689 BE245550 Hs 171825 basic helix-l∞p-hedx domain ∞πtanmg 248 788
421811 AA022550 Hs 108548 PABP-mterxdng protein 2 248 528
414420 AA043424 Hs 6095 immediate early response 3 247 833
420693 NM.001972 Hs 99863 elastase 2, neutrophil 247 278
420139 NM 005357 Hs 95351 lipase, hor one-sensidve 246 1012
447179 AW015633 Hs 157299 ESTs 246 345
451687 AL041260 Hs 26837 Homo sapiens mRNA, cDNA DKFZp586K1123 (f 246 547
420322 AB014555 Hs 96731 huntingdn interxdng protein 1 -related 2 5 6 18
421064 AI245432 Hs 101382 tumor nxrosis fxtor alpha-induced pro 245 575
421818 AW992976 Hs 50098 NM.002489 Homo sapiens NAOH dehydrogenas 245 673
412524 AA417813 Hs 44208 hypothetical protein FLJ23153 244 1055
439639 AA370045 Hs 6607 AXIN1 up-regulated 244 522
436009 H57130 Hs 120925 ESTs 244 294
414814 D14697 Hs 77393 farnesyl dφhosphate synthase (farnesyl 243 5 17
434060 AA744902 Hs 197922 hypothedcal protein PR01489 243 556
425335 BE394327 Hs 296267 follistadn-like 1 243 1052
406997 U07807 metallothionem IV 242 435
431545 AF095703 Hs 8110 L-3-hydroxyxyl-Coeπzyme A dehydrogenase 242 6 72
417029 AW952192 Hs 273385 guanine nudeodde binding protein (G pr 241 5 22
412825 AW167439 Hs 190651 Homo sapiens cDNA FU 13625 fis, clone PL 241 5 56
445462 AA378776 Hs 288649 hypothetical protein MGC3077 241 524
448954 AB014564 Hs 22616 KIAA0664 protein 240 531
447218 BE617762 Hs 10748 hypothedcal protein DKFZp434B195 240 5 24
423810 AL132665 Hs 132955 BCL2/adenovιrus E1B 19kD-ιnterxdng pro 239 555
450440 AB024334 Hs 25001 tyrosine 5monooxygenase/tryptophan δi-mo 239 763
430356 N87990 Hs 239870 Homo sapiens mRNA, cDNA DKFZp564H0764 (f 2 38 599
418355 L42563 Hs 1165 ATPase, W> transporting, nongastnc, alp 238 384
416273 AW575691 Hs 79123 KIAA0084 protein 238 522
427272 NM.001096 Hs 174140 ATP citrate lyase 238 541
437186 AA338305 Hs 5472 hypothetical protein FLJ20173 235 513
443679 AK001810 Hs 9670 hypothedcal protein FLJ 10948 233 581
431179 AI338644 Hs 195432 aldehyde dehydrogenase 2 family (mitxho 2 33 789
418400 BE243026 Hs 301989 KIAA0246 protem 233 536
456876 AL044870 Hs 208780 ESTs, Weakly simila to T29647 hypotheti 232 327
407082 Z47055 gb Human partial cDNA sequence, farnesyl 231 465
426508 W23184 Hs 170171 glutamate-ammonia ligase (glutamine synt 231 937
408536 AW381532 Hs 135188 ESTs 231 260
410552 X66945 Hs 748 fibroblast growth fxtor rxeptor 1 (fms 230 594
437201 F29279 Hs 171625 hypothedcal protein MGC14697 230 575
417314 N68168 gb za11c01 s1 Soares fetal liver spleen 230 3 12
433738 AI684802 ESTs 230 391
410531 AW752953 gb QV0-CT0224-261099-035g02 CT0224 Homo 229 361
422491 AA338548 Hs 117546 neuronadn 229 566
434411 AA632649 Hs 201372 ESTs 228 440
451926 AW134519 Hs 96125 Homo sapiens, Similar to clone FLB3816, 228 514
401131 NM.001651* Homo sapiens aquaponn 5 (AQP 227 562
401205 Target Exon 2 27 298
422109 S73265 Hs 1473 gaston releasing pepdde 226 394
456646 AJ243662 Hs 110196 NICE-1 protein 226 252 443049 AI028613 Hs 132343 ESTs 225 3 13
440160 BE560269 Hs 7010 NPD002 protein 225 493
438367 N79688 Hs 204354 ras homdog gene family member 8 2 25 958
442987 AA075975 Homo sapiens clone TCCCIA00427 mRNA sequ 2 24 6 19
421545 AA292810 Hs 90034 hypothedcal protem FLJ21916 2 24 258
447150 AI439011 Hs 86386 myeloid cell leukemia sequence 1 (BCL2-r 223 903
450014 N41322 Hs 18441 ESTs 2 23 450
426611 BE178050 Hs 171271 catenin (cadheπn-assxiated protein), b 222 564
434039 L32977 Hs 3712 ubiqumol-cytochrome c reductase, Rieske 2 22 557
427569 BE299197 Hs 179665 cyclm-dependent kinase inhibitor 1A (p2 2 22 5 10
444637 T19101 Hs 11494 fibulin 5 222 643
406710 AI708347 Hs 184014 πbosomal protein L31 221 910
424909 S78187 Hs 153752 cell division cycle 25B 220 6 13
407228 M25079 Hs 155376 hemoglobin, beta 220 11 34
450612 AL359946 Hs 14779 acetyl-CoA synthetase 220 703
458568 AI769067 Hs 127824 ESTs, Weakly simila to T28770 hypothed 220 568
407370 AA682384 Hs 182084 ESTs 220 700
438942 AW875398 Hs 6451 PRO0659 protein 2 19 609
400228 NM.021724* Homo sapiens nudea receptor 2 19 695
410185 BE294068 Hs 737 immediate early protein 2 18 11 72
428150 AW950547 Hs 0312 cytxhrome c oxidase subunit Vila polype 217 705
400307 AF005081 Homo sapiens skm-spxific protein (xp32 217 641
424425 AB031480 Hs 146824 SPR1 protein 217 368
414459 Y11525 Hs 76171 CCAAT/enhancer binding protein (C/EBP), 217 311
400082 Eos Control 216 840
434702 AL039734 Hs 4099 nardilysm (N-argimne dibasic convertas 216 683
439651 AF086480 Hs 56255 ESTs 216 372
431838 AI097229 Hs 217484 ESTs, Weakly simila to ALU1.HUMAN ALU S 2 15 334
420225 AW243046 Hs 282076 Homo sapiens mRNA for KIAA1650 protein, 2 14 620
428848 NM.000230 Hs 194236 lepdn (muπne obesity homolog) 214 342
415213 NM 002933 Hs 78224 nbonuclease, RNase A family, 1 (pancrea 214 981
434454 AF217798 Hs 3850 US1-ιnterxtιng protein NUDEL, endoolig 2 14 675
452467 AW500815 ESTs 213 466
418226 AA424202 Hs 83834 cytxhrome 55 213 541
414815 AW292140 Hs 130286 ESTs 2 12 4 14
430967 H16791 Hs 100895 ESTs 212 14
426102 AF200496 Hs 166371 interieukin 1, zeta 2 12 377
410223 S73775 Hs 60708 calsequestnπ 1 (fast-twitch, skeletal m 2 11 530
439518 W76326 gb zd60d04 r1 Soares.fetal.heart_NbHH19W 2 11 401
427228 AA115770 Hs 174051 small nuclear nbonucleoprotein 70kD pol 2 10 5 13
436961 AW375974 Hs 156704 ESTs 2 10 333
417139 M69043 Hs 81328 nuclear fxtor of kappa light polypepdd 210 813
445831 NM.006055 Hs 13351 LanC (bxteπal landbiodc synthetase c 208 542
431593 NM.0O2108 Hs 276590 ESTs 208 443
423887 AL080207 Hs 134585 OKFZP434G232 protein 208 392
424389 AA339786 lymphxyte-spxific protein 1 207 552
407394 AF005081 gb Homo sapiens skm-spxrfic protein (x 206 593
400198 Eos Control 205 1048
426335 AI054347 Hs 2017 πbosomal protein L38 204 557
443652 AI080692 Hs 134229 ESTs, Weakly similar to 154401 hypertens 204 336
448804 AW512Z13 Hs 342849 ADP-πbosylatioπ fxtor-like 5 202 332
443932 AW888222 Hs 9973 tensin 202 9 28
421324 BE257515 Hs 103503 deoxynbonuclease 1-lιke 2 202 5 71
426406 AI742501 Hs 169756 ∞mplement ∞mponent 1, s subcomponent 201 549
410669 AW805749 superoxide dismutase 2, mitxhondπal 201 305
446193 AI279390 Hs 144658 ESTs, Weakly similar to T17257 hypothed 201 2 77
400078 Eos Control 200 11 41
456267 AI127958 Hs 83393 cystadπ E/M 1 99 3 59
413125 BE244589 Hs 75207 glyoxal3se I 1 98 670
415433 W70067 Hs 58066 ESTs 1 98 559
434699 AA643687 Hs 149425 Homo sapiens cDNA FU11980 fis, clone HE 1 98 3 52
417553 L09190 tπchohyalm 1 98 339
403105 Target Exon 1 98 505
414081 AW969976 matnx Gla protein 1 97 874
422639 AI929377 Hs 173724 creadne kinase, bran 1 97 551
452208 AA024792 Hs 31895 hypothetical protein MGC4093 1 97 567
436106 AI050715 Hs 2331 E2F transcnpdon fxtor 5, p130-bιndmg 1 97 575
439265 AL134430 Hs 6906 Homo sapiens cDNA FU23197 fis, clone R 1 96 509
430037 BE409649 Hs 227789 mitogen-xdvated protein kinase-xdval 1 96 549
440054 AW661947 Hs 6891 splicing fxtor, aginme/seπne-πch 6 1 95 595
417088 M54915 Hs 81170 pιm-1 oncogene 1 95 8 19
429451 BE409861 Hs 202833 heme oxygenase (dxyclmg) 1 1 95 519
415274 AF001548 Hs 78344 myosin, heavy polypepdde 11, smooth mus 1 95 678
452472 AW957300 Hs 294142 ESTs, Weakly simila to C55663 oligodend 1 94 598
414860 BE255593 Hs 77502 methionine adenosyltransferase II, alpha 1 94 513
437220 AL117542 Hs 334305 GS1999full 1 94 342
450461 BE408081 Hs 46736 hypothetical protein FU23476 1 94 566
424924 AL039103 Hs 153834 pumilio (Drosophila) homdog 1 1 93 528
413945 NM.000591 Hs 75627 CD14 andgen 1 93 538
428193 NM.004235 Kruppel-like fxlor 4 (gut) 1 93 575
415988 BE407713 Hs 78943 blxmycm hydrolase 1 92 465
425783 AI026740 Hs 1948 πbosomal protein S21 1 92 979
431476 BE612705 Hs 256697 histidine toad nucl∞dde-bindmg prote 1 91 700 456653 AI807519 Hs 104520 Homo sapiens cDNA FU13694 fis, clone PL 1 91 341
401846 NM.000988* Homo sapiens nbosomal protei 1 91 562
428368 BE440042 Hs 83326 matrix metalloproteinase 3 (stromelysin 1 90 400
400199 Eos Control 1 89 1574
429367 AB007867 Hs 278311 plexm B1 1 88 558
400083 Eos Control 1 88 907
433465 AV657778 Hs 3314 selenoprotem P, plasma, 1 1 88 5 16
400079 Eos Control 1 87 857
411807 AK000290 Hs 44033 dipepddyl pepddase 8 1 86 519
409178 BE393948 Hs 50915 kallikrein 5 1 85 275
422624 BE616678 Hs 76152 KDEL (Lys-Asp-Glu-Leu) endoplasmic rede 1 85 533
443121 Z19267 Hs 9006 VAMP (vesicle-associated membrane protei 185 601
451092 AI207256 Hs 13766 Homo sapiens mRNA for FU00074 protein, 1 84 282
430572 U33114 Hs 245188 dssue inhibitor of metalloproteinase 3 1 83 5 10
426812 AF105365 Hs 172613 solute earner family 12 (potassium/chlo 1 83 648
439927 AA854650 Hs 124597 ESTs 1 82 363
415089 N25117 Hs 299465 nbosomal protein S26 1 82 669
406400 kallikrein 8 (neuropsin/ovasin) (KLK8) 1 82 295
406467 Taget Exon 1 79 265
426672 AW270555 Hs 171774 hypothedcal protein 1 79 524
414088 AW797956 Hs 75748 proteasome (prosome mxropan) subunit 1 78 602
433271 BE621697 Hs 14317 nucleolar protein family A, member 3 (HI 1 78 592
429307 AU076592 Hs 198951 jun B proto-oncogene 1 77 544
433640 AW390125 Hs 240443 Homo sapiens cDNA FU23538 fis, done L 1 77 579
425503 W92517 Hs 158203 xdn binding LIM protein 1 1 77 927
429191 AF065215 Hs 198161 phospholipase A2, group IVB (cytosolic) 1 77 544
425875 AU077333 Hs 160483 erythrocyte membrane protein band 72 (s 177 697
431021 AI869664 thiosulfate sulfurtransferase (rhodanese 1 77 523
432891 AF161483 Hs 279761 HSPC134 protein 1 75 573
432872 AI908984 Hs 279623 selenoprotem X, 1 1 75 572
451335 AB023192 Hs 26285 imidazolme rxeptor candidate 1 75 687
428975 NM 004672 Hs 194694 mitogen-xdvated protein kinase kinase 1 74 301
417824 AA084798 Hs 82646 DnaJ (Hsp40) homdog, subfamily B, membe 1 74 575
439908 AI168031 Hs 155507 ESTs 1 74 263
427349 AA360154 Hs 177415 Finkel Biskis-Reilly muπne sar∞ma vim 1 74 680
445919 T53519 Hs 334692 hypothedcal protein MGC14141 1 74 565
427391 W60675 hypothedcal protein FU 10350 1 73 6 13
425299 AW505214 Hs 155560 calnex 1 73 588
430449 AA352723 Hs 241471 RNB6 1 72 514
456766 R87310 Hs 7740 oxysterol binding protein-like 1 1 71 435
407694 U77594 Hs 37682 rednoic acid rxeptor responder (tazaro 1 71 616
412374 X01388 Hs 73849 apolipoprotein C-lll 170 518
417483 BE549343 Hs 82208 xyl-Coenzyme A dehydrogenase, very long 1 70 746
410584 AB011112 Hs 64742 KIAA0540 protein 1 69 6 19
431882 NM 001426 Hs 271977 engrailed homolog 1 1 68 263
441379 AW175787 Hs 334841 selenium binding protein 1 1 67 742
422115 AI878953 Hs 111811 microsomal glutathione S-transferase 3 1 67 693
406742 AI468091 Hs 279860 tumor protein, transladonally-∞ntrolle 1 66 626
432191 AA043193 Hs 273186 hypothedcal protein, clone Telethon(lta 1 65 583
452363 AI582743 Hs 94953 Homo sapiens. Similar to complement ∞mp 1 65 754
446623 AF279865 Hs 15711 kinesin family member 13B 1 65 536
406712 M31212 Hs 77385 myosin, light polypepdde 6, alkali, smo 1 65 1230
400202 NM 002795* Homo sapiens proteasome (pros 1 64 5 70
401429 C14001067 gι|4126465|dbj|BAA36581 1| (AB 1 64 382
415166 NM 003652 Hs 78068 carboxypepddase Z 1 62 595
410169 AI373741 Hs 59384 hypothetical protein MGC3047 1 61 660
406713 U02629 Hs 77385 myosin, light polypepdde 6 alkali, smo 1 60 11 13
453027 AI879341 Hs 539 nbosomal protein S29 1 60 1097
416955 AW889150 Hs 80595 NM.004552* Homo sapiens NADH dehydrogena 1 60 590
439053 BE244588 Hs 6456 chaperonin containing TCP1, subunit 2 (b 1 57 560
400201 NM.006156* Homo sapiens neural precursor 1 57 532
407049 X72632 NM.021724* Homo sapiens nuclea rxeptor 1 57 542
430775 AI879186 Hs 250895 nbosomal protein L34 1 57 709
427380 NM 005534 Hs 177559 interferon gamma rxeptor 2 (interferon 1 56 537
407143 C14076 Hs 332329 EST 1 56 654
436127 W94824 HS 11565 RIKEN cDNA 2010100012 gene 1 56 6 35
413659 BE155647 gb PM2-HT0355130105002-e09 HT0353 Homo 1 55 596
445624 AW140103 Hs 78880 ilvB (bxtenal xetolxtate synthase)-! 1 55 409
435044 NM 002802 HS 4745 proteasome (prosome, mxropan) 26S subu 1 55 571
410397 AF217517 Hs 63042 DKFZp564J157 protein 1 54 514
429071 AW794126 Hs 195453 nbosomal protein S27 (metallopansdmuli 1 54 870
412915 AW087727 Hs 74823 NM 004541 Homo sapiens NADH dehydrogenas 1 54 657
446429 AI681807 Hs 201391 ESTs 1 53 287
414551 AI815639 Hs 76394 enoyl Coenzyme A hydratase, short chain. 1 53 607
406801 AW242054 Hs 190813 nbosomal protein L9 1 52 563
437895 AB014568 Hs 5898 KIAA0668 protein 1 51 574
413929 BE501689 Hs 75617 collagen, type IV, alpha 2 1 51 640
425456 T70445 Hs 157850 nbosomal protein L9 1 51 708
409635 Z37166 Hs 55296 HLA-B assxiated lranscnpt-1 1 50 526
404467 Target Exon 1 50 582
406743 AA911568 Hs 279860 tumor protein, translationally-controlle 1 50 525
454098 W27953 Hs 292911 Plakophilin 1 48 3 14
429205 AI492393 Hs 198248 UDP-Gal betaGlcNAc beta 1,4- galxtosylt 1 48 6 24 413825 BE299181 Hs 75564 C0151 antigen 1 47 564
421143 AB024536 Hs 102171 immunoglobulin superfamily containing le 1 45 619
440254 AI879332 Hs 7101 anaphase-promoting complex subunit 5 1 45 550
406711 N25514 Hs 77385 myosin, light polypepdde 6, alkali, smo 1 42 11 24
423513 AF035960 Hs 129719 transglutaminase 5 1 42 318
406896 D00159 gb Homo sapiens gene for pancreatic elas 1 41 692
433453 BE548307 Hs 3297 πbosomal protein S27a 1 40 538
406800 AA505535 gb nh84h10 s1 NCI_CGAP_Br1 1 Homo sapien 1 37 551
421748 NM 014718 Hs 107809 KIAA0726 gene product 1 37 546
424372 AW952803 Hs 21732 Homo sapiens cDNA FU11780 fis, clone HE 1 36 406
408250 R92918 Hs 19597 KIAA1694 protein 1 27 274
431931 AB035302 Hs 272212 cadheπn 9, type 2 (T1-cadheπn) 1 15 265
406587 C15000544* gι|5454148|ref|NP 006368 1| U 1 06 311
409574 AW419080 Hs 250645 ESTs 1 00 360
404175 Target Exon 1 00 308
452640 AA027115 Hs 100206 ESTs, Weakly similar to A53856 aryl-xyl 1 00 282
443564 AI921685 Hs 199713 ESTs 1 00 251
TABLE 65B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Axession Genbank axession numbers
Pkey CAT Number Accession
407328 534268 1 AI673735 AA978066
427890 1373988 1 AA417099 AA435761 AA972917 AI660387
444207 9172 3 BE739425 AA514221 AA865491 AI828293 AA470456 AI276739 AA1
AI247243 BG533994 AA513783 AI887309 AA528036 AW972006 AW873028 AI924914 AI818810 AW152378 AW084946 AI521413 AI669583 BE932521 AI581370 BE180238 AW089750 AW771461 AW089714 AI590949 AI819148 AA731056 BF815234 BF911506 AA235803 AA485373 AI735658 AW393133 AW073080 AI707637 BF353320 BE843111 AW819036 AW393135 BG697291 AV648670 AV654332 AV687530 BG566964 AI807430 AI676072 AA837010 AI452482 AI625817 AW241750 BE048616 AI290928 AI680714 AA485530 BE175687 AV648513 AW130312 AI000556 AA632893 BE674169 BF001208 AA948166 BE175650 AA524664 AA490345 AI244948 AA602956 AA483492 AA918178 AW802049 BG675859 AV658871 BG678060 AI5650O4 AW819026 BE843092 AV686437 AV723049 BG616948 AI911647 AI743490 AI091096 BE857251 AI962074 AA040027 AW769317 AA343477 AA640112 BF876213 R82948 H26425 H82876 BE843095 BE843140 BG536641 BG617830 AA235802 BE774985 BE006682 BF342375 AA903144 BF338083 BF984258 AV657996 AI749532 BE768614 BE857252 BE932516 BE768573 AV657993 AV657777 AV752631 BE774974 T55847 BF095761 BF911511 BE710793 BE180119 BG617338 H45942 T55897 AV657718 BG563497
407102 7177.2 AW945170 BF930905 F33652 BG057818 AI368018 AI421485 AI300352 AI378525 AI264177 AI276281 AI245302 AI281050 AI190036 AW451438
AW242903 AA910870 F22289 F19647 F22375 AW473816 BF445785 AA774528 F33447 C01077 AW772227 F17759 H42812 R09701 AA349096 R48772 H42892 H42537 R47898 N28263 H25721 F32386 H43971 R48205 F21390 H45809 AA007629 R47897 R83734 H45844 AW983653 H43970 H42536 H24495 R48875 H42961 H22079 R86018
437596 2875.1 BC022398 AV743635 AW976922 AW152652 AA910013 AA834629 BG536317 AW849807 AV713062 AI684337 BE044081 AA761490
440116 454673.1 R69942 BG655457 BF111453 AI149320 N23160 AI446431 AI758316 AV741781 BI791950 BM055014 AI798851 AA865357 AI417230 N67277 T55592 T52179
443072 449629.1 AV734838 AI937532 AI032318 AW749500 AA091 20
442679 31783.3 BG621493 BI056706 BG496376 R53718 W65356 R79357 BG434247 AA357769 AW978686 BG573200 BF132113 BF086709 AA366938 D79234
BG494628 AA156754 BG434311 AW978683 AW273417 BM054662 Al 799886 AI433351 AI160798 AI433742 BF056186 Al 281606 AW015046 AI439585 AI245530 AI078267 AA807170 AA837395 W61252 AA831085 AA287371 AW768354 AA890606 AI302539 AI708575 AI673031 AI242260 AW514069 AA283958 AA825452 AI371234 AA425696 AA453422 AA827697 R23653 D2024O AA772517 H13802 R66972 R79360 R27351 F03379 AA031952 N69504 R33143 R79358 R39136 R38800 R15089 R52937 R37502 H01021 R33634 R46551 Z40404 BG291052 BG570357 AW391046 BG496872 H23558
424571 9758.1 BE379766 AW152643 AI8034S0 AI564343 AI092711 AI140525 AW152156 AI620740 A1554689 AI161209 AI290242 AI339745 A1374611 A1347388
AI858296 AI140529 AI366124 AA493912 AA406235 AA493889 AI057160 AW022264 AI097277 AI144126 AI080051 AA983529 AA860507 N53469 AA843767 N81163 N70628 AA424577 AA983537 BF003004 AA626688 AA235977 AI057152 AI095366 AI095356 AA458646 AW194479 AA150439 AI375272 AW571777 AI359198 AA993793 BE614394 BE738239 AA127883 AI034344 T59504 D81608 AA908704 AW051665 AA382785 AA307208 N24639 AI370715 BE244980 AA548596 AW449675 AI191008 BF223749 N70752 N22266 AI191012 AA028001 AI419106 BF215661 BF591548 BG942356 AI474968 BE858217 BF793358 AV756758 BG483603 AI093724 BF693395 BG545345 AI744294 T59549 AA811773 BG499757
420787 55832.7 BE674920 AA564248 AA280309
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424389 1059.4 BG190758 AW961118 W77994 AA339877 AW845121 AW845129 BG181820 BE716719 AI125483 AI161017 W73951 AI250771 AA912611 AA339786 BE838286 BE838282 BE716636AA777158 W94063 BE716628 BE716625 BE838371 BF371044 BE716631 BE716402 4 40077339944 2 27711110022 AF005081 BG193848
410669 427316 AW796921 AW798102 AW805749 AW805872 BF985060 AW794380 BF380449 AW794466 AW794538
417553 2588571 AL545411 AI096369 BF431750 AI130946 W60065 W80663 AA258580 W73279 W76156 W80662 AW058658 AI204699 W60115 N56751 N30878 AI769345 R71250 AI363766 R22777 R17009 R27985 R28243 414081 19335 1 BI754027 BF696071 AI351939 BG151298 AI919334 AI401620 B!770165 W72057 T96158 T29478 AA181252 BG927793 AA714431 AA600749 AA181247 AA614756 AA081092 H52207 BG926934 BF222579 BG899001 N64245 AA953040 AI832406 AA102441 BG928081 AA993445 AA916041
AA987847 AA983329 AA737219 AA916443 AW128994 AI492560 AI761847 BC005272 NM.000900 X53331 M58549 BI758966 AL598829 BI754530 BG699770 BE439699 BE440148 AV704365 AV733652 BG212015 BG184149 BG200180 BG212690 BI761222 BG182079 AW338822 AI925631 AI423041 AW071181 AI889836 AW129112 BG925339 AI017633 AA568964 BF725590 AI004210 AI809799 BE083097 BG896220 AW997681 BF668788 BE083134 AW631281 BG193052 BG183095 BE440088 BG185728 AI499579 AA188162 AA864282 BI493352 AA155854 AA836749 AA836844 AA985478 AW082299 AI816747 AA450221 AA971294 BE327509 AI719662 BG576669 AI479382 BF824747 AI741800 BG982962 AI088473 AA916151
AW473324 BG901177 BE439998 AW023269 BE813871 AW999947 BE839108 AV707983 AA369722 AW796627 AW890608 AI341771 AA302459 BI493353 AA366332 AA371104 AA367277 AL547972 BG928011 AI678903 AI699886 AI956165 AA484893 AA643953 AW591063 BG203275 BG211093 AI334791 AA916589 AW058266 AI362370 AI143352 AA508721 AI928079 D57214 BE045265 AA541785 BG219510 BG201686 BG195572 AW019904 AW089242 AA953322 AI686698 F27562 AA614749 D56645 F20774 F30660 F25646 AW023542 AA827300 AA582214 AI701289 AA228293 AI906950 AA230156 AA384572 AW438988 AA742516 BI490938 AA731082 BF665869 BG190518 AV704158 BE439543 AA910666 AA155913 AA923097
AA975721 AA985555 BG927032 AA948389 AA451625 AA916141 AL572719 AV707258 AW083733 AA128053 AI953789 AI911993 AA421798 BG429150 AI915306 Z30130 AA126929 BG926630 AA081013 AA553696 AA916094 BG924321 AI039722 AI954968 AI372839 AI401406 AI538215 428193 430.1 AF105036 U70663 NM.004235 AF022184 AU141767 AU141110 AL040569 D44830 BI011351 AL575805 AI290876 AI014784 AI393429 AI266211
AW074303 AA620711 BF197792 AW008766.D25944 AI687397 AA621680 AV714408 BF446905 BM314505 BF514079 BM314197 AA845201 AW874084 BE720622 AI127241 AA236239 AI679709 AI679135 AI572470 AA573434 AI568487 BE049325 AA687950 BG925989 AI338031 AI365073 AI024576 AA298805 H04001 H45668 BG682146 AL552388 BI462361 BG547513 BG896863 BI256661
431021 10409 1 NM 003312 BC010148 AK000862 D87292 BG709214 BF972766 BG740474 BI771592 BI159859 BI820468 BI523933 AI869664 AA314620 BF724353
BGΪ94276 BG195282 BI524679 BF435589 AI300546 AA481682 AW780207 AI800832 AI380540 BE222877 AW300707 AA481445 AW015893 AI381541 AA768558 AI138798 AA432063 AA948713 AI869485 AI307419 AI336589 AI301672 BF055581 AI312785 AI521208 AI927918 AI989759 M78015 BF718621 AI927654 AI795909 AI335381 BF334524 AW007444 AA706797 AA975178 AA884739 AA443837 AA933897 AI826464 AI271737 AA053419 H79704 AI984483 BG952614 BF345358 AW083336 AA643660 AI478232 AA603071 BE714413 AW078660 AW070418 R02364 BG925951 AL568823 AA053459 AA446748 BG954446 BF760569
427391 9048.3 AY007099 AU150467 AI127583 BE735800 Al 125772 AI373009 AI215670 AI769136 AA586848 AW451158 N50799 AA936337 AI355427 BE677905
AW338O20 BG151557 AA657954 AI754947AW467279AI128755 BF448136 AI369247 BF439175 BE207948 AI089272 BI911455 AA42072O F36980 AI494204 AA953319 AA155753 AI052675 AA044804 AI282678 BG741226 F25798 AA180204 AI682613 AU152630 AA420766 AI373393 AI885767 T03896 BF939430 AA974325 AW072996 AW005963 BG252471 AI192002 AI918908 AA776144 BI834864 AI753954 BE908511 AW628731 AA034958 BF447074 AW194649 AI915192 AL567164 BF691569 AL565970 AW471137 AW276992 AL536717 BF591783 AI571746 BF939172 BG745029 BG575588 BI054960 H51485 AW799491 AI370437 H26413 AA585334 AU151276 AA074274 AA936883 AW131643 AI221650 AW105476 AW952294 H23835 BI035010 F22360 BF849322
400202 11771.2 BE873890 BF745945 AA156007 AA573157 AW874610 AA916387 N75963 BM083306 AW044671 BCO13008 NM.002795 D26598 BG118716 BI910891
BF972860 BG119842 BI094093 AL538757 BE271653 BI856538 BE909573 BG109826 BE784430 BE899255 BI833973 BM010809 BE621321 BG684956 BE904726 BI871370 AV708990 BF971483 BE298241 BI1970078E272092 BG120374 AW963509 BE540572 AV744947 BG943041 AW327463 BG472870 BE393697 N28533 AA316042 N42043 AW404246 AW892094 AA379896 AW801110 AW406977 AA379791 BG941889 BE076254 AA360459 AA379385 AA320056 BG942618 D31230 AA308300 AA360371 AA371733 AA732937 AA494241 W32225 BF745937 AI383690 BG202360
400201 24179.2 NM.006156 D23662 BF038671 BI670321 BI603145 BI666956 BG716628 BG707476 BG768814 BE312007 BF125930 BF037916 BG942671 AI752472
AW009362 BE379126 BI198555 BF126026 N28289 BE388301 BG327102 AI571450 BF038400 AI884649 AI718962 AI742314 AA977058 AM 50699 BG944784 AA187402 BG283893 AV712007 W01301 BG774109 W77840 C15672 BI670016 AI752473 AA484409 C14921 N41745 C15220 F30164 AA133181 BF768974 H30334 AA034968 AA384232 AA353297 AW407023 AA337516 F36177 AA374444 AA402758 AI141545 BI021470 AA973914
413659 1526081.1 BE155647 BE155627 406800 0.0 AA505535
TABLE 65C
Pkey Unique number corresponding to an Eos probeset
Ref Sequence source The 7 digit numbers in this column ae Genbank Idendfier (Gl) numbers "Dunham, et al " refers to the publicadon endtled 'The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402485495
Strand Indicates ONA sfrand from which exons were predicted NLposition Indicates nudeodde posidoπs of predicted exons
Pkey Ref Strand Nt position
405121 8102330 Minus 3581536004,36587-36684
401203 9743387 Minus 172961-173056,173865173928
400494 9714719 Plus 169845170272
402294 2282012 Minus 25753000
404730 8389582 Plus 119832-120016,124115124275
403593 6862650 Minus 62554-62712,69449-69602
403710 6437516 Plus 2741528978
401905 8671966 Plus 153965154441 , 156595156819
403108 8980955 Plus 9325593667
404996 6007890 Plus 3799538145,38652-38998,39727-39872,4055
402315 7381741 Minus 3072532065
401131 8699812 Minus 94802-94987,95804-95887,9632596487,9759
401205 9743388 Plus 167375167433,167935168031
403105 8980016 Minus 145287-145744
401846 7712190 Minus 8277582823,82912-83022
406400 9256298 Plus 15551712,18752140,4252-438559226077
406467 9795551 Plus 182212-182958
401429 8217890 Minus 8694587579
404467 8077630 Minus 24951-25853
406587 8189273 Minus 120577-120718
404175 9931117 Minus 107425107547,109625109796
TABLE 66A DISEASE INDICATIONS AND PREFERRED UTILITIES FOR SELECTED GENES
Table 66A provides disease dicadons and preferred utilities for about 439 selxted genes These genes were idendfied using Eos/Affymetox Genxhip anays
Pnmekey Unique Ex probeset idendfier number
ExAxn Exemplar Axession number UglD Unigene ID number UgTide Unigene title Disease diseases indicated for selxted gene as described in table 1 and abbreviated as follows AWPC (androgen independent prostate diseases), arth (arthndc diseases), bph (benign prostatic hyperplasia), blad (bladder diseases), angio (blood vessel diseases), EWS (bone diseases), glio (bran diseases) breast (breast diseases), cerv (cervical diseases) colon (colorxtal diseases), esoph (esophageal diseases), fibro (fibrodc diseases), headnk (head & nxk diseases), leio (leiomyoma diseases), leuk (leukxyte diseases), hepC (liver diseases), lung (lung diseases), ova (ovaian diseases), endo (ovanan endometooid diseases), omuc (ovanan mucmous diseases), pane (pancreadc diseases), pros (prostate diseases), renal (renal diseases), mela (skin diseases), stem (stomxh diseases), test (tesdcular diseases) uter (utenne diseases)
Utility preferred utilities for selxted gene as descnbed in the text and abbreviated as follows CTL (DNA vaxme target) diag (diagnostic or prognostic tagel), mAb (monxlonal antibody target), s m (small molxule target)
Pnmekey Ex Axn UglD Ug Title Disease Utility
400289 X07820 Hs 2258 matnx metalloproteinase 10 (stromelysm angio, blad, lung, cerv, ovar, headnk, esoph mAb*dιag*s m
400297 AI127076 Hs 306201 hypothetical protein DKFZp56401278 breast, blad, colon, pros mAb
400303 AA242758 Hs 79136 LIV-1 protein, estrogen regulated breast, ovar, pros, stom, uter, blad, lung, headnk mAb
400843 NM.003105* Homo sapiens sortilm-related blad s m
402075 ENSP00000251056' Plasma membrane calcium blad, lung headnk, ceiv, mela, esoph mAtπdiag
402901 NM.025206* Homo sapiens hypothetical pro blad CTL
404287 FGENESH predicted novel CUB-doman conta pane, lung, cdon, uter, esoph mAb+s m 404682 ortholog of mouse polydoman protein pane diag
404875 NM.022819' Homo sapiens phospholipase A2 blad CTL+s m
404977 Insulin-like growth fxtor 2 (somatomedi blad, ovar mAb-idiag
405033 C1002652* gι|544327|sp|Q04799|FMO5.RABIT blad s m
405547 NM.018833* Homo sapiens transporter 2, A cerv, mela mAb+s m
406400 kallikrein 8 (neuropsin/ovasm) (KLK8) ovar, uter diag
406964 M21305 FGENES predicted novel sxreted protein angio, blad, fibro diag
407603 AW955705 Hs 62604 Homo sapiens, clone IMAGE 4299322, mRNA, glio, blad CTL
407792 AI077715 Hs 39384 putative sxreted ligand homdogous to f ovar, uter, ∞rv, pane mAb+diag
407811 AW190902 Hs 40098 cysteine knot superfamily 1, BMP antagon blad, pane, stom, uter, lung, esoph diag
407836 T79340 Hs 22575 E ell CLUlymphoma 6, member B, zinc fi angio CTL
407975 X89426 Hs 41716 endothelial cell-spxific molxule 1 angio, renal diag
408243 Y00787 Hs 624 interieukin 8 blad, stom, headnk, ∞rv, lung, angio, esoph, pane diag
408367 AK001178 Hs 44424 Homo sapiens orphan neurotransmitter tra mela mAb+s m
408369 R38438 Hs 118747 SLC15A2 Solute earner family 15 (H+/pep pros, lung, fibro, uter, glio, cerv, ovar mAb
408380 AF123050 Hs 44532 diubiquidn lung, blad, headnk, pane, stom, fibro, esoph, mela CTL
408482 NM 000676 Hs 45743 adenosine A2b rxeptor lung, esoph, headnk mAb+s m
408562 AI436323 Hs 31141 roundabout (axon guidance rxeptor, Dros uter, fibro mAb+s m
408790 AW580227 Hs 47860 neurotrophic tyrosine kinase, rxeptor, lung mAb+s m
408908 BE296227 Hs 250822 εeππe/threonine kinase 15 blad, lung, headnk, stom s m
409041 AB033025 Hs 50081 Hypothedcal protein, XP.051860 (KIAA119 uter, ova, lung, ∞lon, stom, headnk, breast pane CTL+diag
409079 W87707 Hs 82065 interieukin 6 signal transducer (gp130, breast pros mAb+s m
409103 AF251237 Hs 112208 XAGE-1 protein lung CTL
409178 BE393948 Hs 50915 kallikrein 5 ova, breast mela diag
409220 BE243323 Hs 51233 tumor nxrosis fxtor rxeptor superfami angio, renal, colon, stom mAb+s m
409348 AI401535 Hs 146090 ESTs renal, glio mAb+s m +CTL
409389 AB007979 Hs 301281 Homo sapiens mRNA, chromosome 1 spxific glio mAb+diag
409420 Z15008 Hs 54451 laminin, gamma 2 (nicein (100kD), kaliπi lung, headnk pane, stom, cerv, esoph, blad diag
409632 W74001 Hs 55279 senne (or cysteine) proteinase inhibito lung, blad, headnk diag
409637 AA323948 Hs 55407 Homo sapiens mRNA, cDNA DKFZp434K0621 (1 renal mAb+s m +CTL
409663 AI743750 Hs 98306 KIAA1862 protein renal CTL
409745 AA077391 gb 7B14E12 Chromosome 7 Fetal Bran cDNA ova, renal mAb+s m +CTL
409757 NM 001898 Hs 123114 cystadn SN pane, stom, lung blad, diag
409893 AW247090 Hs 57101 minichromosome mantenance deficient (S lung, cerv, blad, test, esoph CTL+s m
409956 AW103364 Hs 727 inhibiπ, beta A (xdvm A, xdvin AB a breast, pane, ovar, ∞lon, headnk, lung, blad esoph diag
410001 AB041036 Hs 57771 kallikrein 11 ovar, pros, uter, cerv, lung diag
410055 AJ250839 Hs 58241 gene for seπne/threoπine protein kinase renal s m
410153 BE311926 Hs 15830 hypothedcal protein FU12691 renal, blad CTL
410274 AA381807 Hs 61762 hypoxia-mducible protein 2 lung, renal CTL
410309 BE043077 Hs 278153 alpha-2,5sιalyltransferase III pane s m
410407 X66839 Hs 63287 cart-onic anhydrase IX renal, lung, colon stom, ovar, uter, blad mAb+s m
410418 D31382 Hs 63325 transmembrane protease, senne 4 xlon, blad, lung, ovar, pane, headnk mAb+diag+s m
411274 NM.002776 Hs 69423 kallikrein 10 colon, ovar, uter, cerv, headk, pane diag
411411 AA345241 Hs 55950 ESTs, Weakly similar to KIAA1330 protein renal mAb+s m
411773 NM 006799 Hs 72026 protease, serine, 21 (tesdsin) ovar diag
412078 X69699 Hs 73149 paired box gene 8 ovar CTL
412140 AA219691 Hs 73625 RAB6 interxdng, kinesm-like (rabkmes lung. Wad, headnk, breast ova, pane, angio, test mela s m
412580 AA113262 Hs 17901 similar to CABLES [Homo sapiens] mela mAb+s m +CTL
412609 Z48804 Hs 74124 xular albinism 1 (Nettleship-Falls) mela s m
412628 AI972402 Hs 306051 hypothedcal protein MGC2648 pros diag
412709 AL022327 Hs 74518 KIAA0027 protein glio mAb+s m
412719 AW016610 Hs 816 ESTs lung, headnk, blad, glio cerv s m
412959 D87458 Hs 75090 KIAA0282 protein glio CTL+s m
412986 X81120 Hs 75110 cannabinoid rxeptor 1 (brain) glio mAb+s m
413048 M93221 Hs 75182 mannose rxeptor, C type 1 fibro, pane mAb
413063 AL035737 Hs 75184 chitmase 3-lιke 1 (cartilage glycoprote glio, ovar, blad, lung diag
413278 BE563085 Hs 833 interferon-sdmulated protein, 15 kDa pane, lung, blad, breast, cerv ovar, headnk, esoph, mela, stom CTL+s m
413324 V00571 Hs 75294 ∞rd∞tropin releasing hormone blad diag
413385 M34455 Hs 840 doleamine-pynole 2,3 dioxygenase blad, lung, mela, fibro, uter s m
413554 AA319146 Hs 75426 sxretogranin II (chromogranm C) pane, glio diag
413719 BE439580 Hs 75498 small inducible cytokine subfamily A (Cy pane, lung headnk, cerv, ∞lon, uter, stom, esoph diag
414577 AI056548 Hs 72116 hypothedcal protein FLJ20992 simila to angio CTL+diag
414774 X02419 Hs 77274 plasminogen xdvator urokmase lung blad, headnk, pane, stom, ova, esoph diag
414812 X72755 Hs 77367 monokme induced by gamma interferon breast blad, lung, fibro, pane, ∞lon, headnk, cerv, stom, renal, ovar, test mela, esoph diag
414825 X06370 Hs 77432 epidermal growth fxtor rxeptor (avian glio, lung, renal, esoph, pane, headnk, arth mAb+s m +CTL
414883 AA926960 Hs 348669 CDC28 protein kinase 1 lung ova stom, colon, cerv headnk, test s m
414907 X90725 Hs 77597 polo (DrosophiaHike kinase blad, lung, ovar, test s m
414945 BE076358 Hs 77667 lymphxyte antigen 6 complex. Ixus E mela mAb+s m
415138 C18356 Hs 295944 dssue fxtor pathway inhibitor 2 angio, pane, stom, lung uter CTL+diag
415511 AI732617 Hs 182362 ESTs blad, ovar, renal mAb+s +CTL
415539 AI733881 Hs 72472 BMP-R1B breast uter, pros mAb+s m
415668 AW957684 Hs 306814 Homo sapiens lysyl oxidase-like 4 (LOXL4 mela diag
415669 NM.005025 Hs 78589 senne (or cysteine) proteinase inhibito lung mAb+diag+s m
415817 U88967 Hs 78867 protein tyrosine phosphatase, rxeptor-t lung, glio, headnk, cerv, mela, esoph, fibro mAb+s m
415910 U20350 Hs 78913 chemokine (C-X5C) receptor 1 glio mAb+s
415929 AA724373 Hs 304950 Homo sapiens mu∞lιριn-3 (MCOLN3) mela mAb
415989 AI267700 Hs 351201 ESTs pros, ova, blad lung headnk, pane, colon stom mAb+s m +CTL
416091 AF295370 Hs 283082 defensin, beta 3 headnk, esoph, mela CTL+diag
416209 AA236776 Hs 79078 MAD2 (mitodc anest deficient, yeast, h lung, headnk, ∞lon, uter, stom CTL+s
416250 AA581386 Hs 73452 Kremen 2 esoph, lung, cerv, ovar mAb+s m
416350 AF188625 Hs 189507 phospholipase A2, group IID test, mela, fibro CTL
416530 U62801 Hs 79361 kallikrein 6 (πeurosin, zyme) ovar, uter diag 416636 N32536 Hs 42645 solute earner family 16 (monxarboxylic breast pane, uter, mela mAb+s m
416658 U03272 Hs 79432 fibπllm 2 (∞ngemtal confrxtural ara lung, ova, uter, blad, angio, test diag
416836 054745 Hs 80247 cholxystokinm pros, EWS, glio diag
416857 AA188775 Hs 292453 FGENESH predicted TM containing protein glio mAb+s m
417034 NM 006183 Hs 80962 neurotensin lung, headnk, cerv diag
417079 U65590 Hs 81134 interieukin 1 rxeptor antagonist blad, lung, headnk, cerv, esoph diag
417166 AA431323 Hs 42146 Paired box protein Pax-3 mela CTL
417355 D13168 Hs 82002 endothelin receptor type B glio, mela mAb+s m
417389 BE260964 Hs 82045 midkme (neuπte growth-pro odng fxtor ova, lung, blad, uter, cerv, pane, stom, mela, test colon mAb+diag
417433 BE270266 Hs 82128 5T4 on∞fetal trophoblast gly∞protein pane, breast, Wad, lung, headnk, ∞rv, uter, ovar, stom, renal mAb
417542 J04129 Hs 82269 progestagen-ass∞iated endometπal prote lung, mela mAb+diag
417771 AA804698 Hs 82547 rednoic xid rxeptor responder (tazao blad, cerv, pane, ovar mAb
417866 AW067903 Hs 82772 collagen, type XI, alpha 1 lung, pane, breast, ova, headnk, stom CTL
417931 W95642 Hs 82961 trefoil factor 3 (intesbπal) ova, pane, stom, colon, uter, pros diag
417933 X02308 Hs 82962 thymidylate synthetase blad, lung, angio, ∞lon, pane, esoph s m
418007 M13509 Hs 83169 matnx metalloproteinase 1 (interstitial lung, Wad, fibro, headnk, pane, stom, ∞lon, ova, esoph, mela mAb+diag+s m
418030 BE207573 Hs 83321 neuromedm B glio, pane diag
418064 BE387287 Hs 83384 SlOOcalcium-binding protein, beta (neur mela diag
418281 U09550 Hs 1154 oviductal gly∞protein 1, 1 0kD (mucin 9 uter, ova CTL+diag
418478 U38945 Hs 1174 cyclin-dependent kinase inhibitor 2A (me lung, blad, ova, headnk, pane, ∞rv, mela s m
418506 AA084248 Hs 372651 Unknown protein for MGC 29643 (formerly angio, ova, glio, uter, lung, blad, pane, mela mAb+diag
418526 BE019020 Hs 85838 solute earner family 16 (monxarboxylic lung, blad, renal, pane, stom, ∞lon, ovar mAb+s
418558 AW082266 Hs 86131 Fas (TNFRSF6)-assxιated via death domai esoph, headnk s m
418678 NM 001327 Hs 167379 cancer/tesbs andgen (NY-ESO-1) lung, blad, stom, ovar, pax, esoph, cerv, mela CTL
418830 BE513731 Hs 88959 hypothedcal protein MGC4816 lung CTL
418867 D31771 Hs 89404 msh (Drosophila) homx box homolog 2 blad s m
418870 AF147204 Hs 89414 chemokine (C-X-C modf), rxeptor 4 (fus leuk, ova, breast, blad, renal mAb+s m
419080 AW150835 Hs 18878 hypothedcal protem FU21620 renal, uter, lung CTL
419121 AA374372 Hs 89626 parathyroid hormone-like hormone lung, esoph, headnk, Wad diag
419171 NM.002846 Hs 89655 protein tyrosine phosphatase, rxeptor t lung mAb+s m
419172 AW338625 Hs 22026 ESTs, similar to TRANSMEMBRANE 4 SUPERFangio renal mAb+s m
419183 U60669 Hs 89663 cytxhrome P450, subfamily XXIV (vitamin blad, lung, headnk, pane CTL+s m
419216 AU076718 Hs 164021 small inducible cytokine subfamily 8 (Cy pane, lung, stom, cerv, pros, headnk, esoph diag
419235 AW470411 Hs 288433 neurotπmin pane, fibro, headnk, lung mAb+diag
419452 U33635 Hs 90572 PTK7 protein tyrosine kinase 7 ova, pros, lung, breast, uter, test, pane, stom mAb+s m
419508 AW997938 Hs 90786 ATP-bindmg cassette, sub-family C (CFTR glio, omuc, stom, lung, pane, colon, renal, uter mAb+s m
419556 U29615 Hs 91093 chidnase 1 (chitotoosidase) lung, fibro, test mAb+diag
419704 AA429104 Hs 45057 ESTs glio CTL+s m
419723 AL120193 Hs 339810 longevity assurance (LAG1, S cerevisiae glio mAb+diag
419741 NM 007019 Hs 93002 ubiquitin earner protein E2-C blad, lung, colon, ovar, test, esoph, mela CTL+s m
420159 AI572490 Hs 99785 Homo sapiens cDNA FU21245 fis, clone C blad, stom mAb
420162 BE378432 Hs 95577 cyclin-dependent kinase 4 lung mela s m
420208 BE276055 Hs 95972 silver (mouse homolog) like mela CTL
420370 Y13645 Hs 97234 uroplakin 2 blad mAb
420440 NM.002407 Hs 97644 mammaglobm 2 ovar, uter, ∞rv diag
420602 AF060877 Hs 99236 regulator of G-protem signalling 20 headnk, glio, ceiv, mela CTL+s m
420610 AI683183 Hs 99348 distal-less homeo box 5 uter, endo, lung CTL
420737 L08096 Hs 99899 CD70 , tumor nxrosis fxtor (ligand) s renal mAb+s m
420789 AI670057 Hs 199882 ESTs renal mAb+s m +CTL
420876 AA918425 Hs 177744 FGENES predicted novel protein coπtanm pane, blad s m
421066 AU076725 Hs 101408 branched chain aminotransferase 2, mitx blad, lung CTL+s m
421110 AJ250717 Hs 1355 cathepsin E blad, pane, stom, lung fibro, ova, esoph sm+diag
421340 F07783 Hs 1369 dxay axeleratmg fxtor for complement angio, pane, stom diag
421379 Y15221 Hs 103982 small inducible cytokine subfamily B (Cy breast, pane, headnk, lung, stom, blad, cerv, ∞lon, fibro, test mela esoph diag
421471 U90545 Hs 327179 solute earner family 17 (sodium phospha renal mAb+s m
421474 U76362 Hs 104637 solute earner family 1 (glutamate trans lung mAb+s m
421508 NM 004833 Hs 105115 absent in melanoma 2 blad, esoph, lung, mela mAb+s m +CTL
421524 AA312082 Hs 105445 GONF family rxeptor alpha 1 breast mAb+s m
421552 AF026692 Hs 105700 sxreted fπzzled-related protein 4 breast, ovar, pane ∞rv, uter, pros, lung, stom, headnk diag
421574 AJ000152 Hs 105924 defensin, beta 2 headnk, lung CTL+diag
421582 AI910275 Hs 350470 trefoil fxtor 1 (breast cancer, esfroge breast pane, lung, omuc diag
421666 AL035250 Hs 1408 endothelin 3 mela mAb+diag
421753 BE314828 Hs 107911 ATP-bmding cassette, sub-family B (MDR/ lung mAb+s m
421817 AF146074 Hs 108660 ATP-bindmg cassette, sub-family C (CFTR lung, cerv, headnk, blad mAb+s m
422033 AW245805 Hs 110903 claudin 5 (transmembrane protein deleted glio mAb+s m
422048 NM 012445 < Hs 288126 spoπdin 2, extrxellular matπx protein pane, pros diag
422109 S73265 Hs 1473 gastπn-releasing peptide pane, lung, colon, fibro diag
422158 L10343 Hs 112341 protease inhibitor 3, skin-denved (SKAL headnk, blad, lung, ∞rv stom, esoph diag
422163 AF027208 Hs 112360 prominm (mouse)-lιke 1 ∞lon, breast fibro mAb+s m
422192 AA305159 Hs 113019 fls485 mela s m
422260 AA315993 Hs 105484 regeneradng gene type IV ∞lon, omuc, stom, pane mAb+diag
422282 AF019225 Hs 114309 apolipoprotein L blad, lung, headnk, renal diag
422283 AW411307 Hs 114311 CDC45 (cell division cycle 45 S cerevis lung, blad, test, cerv, headnk, esoph s m
422309 U79745 Hs 114924 solute earner family 16 (monxarboxylic mela mAb+s m +CTL
422330 D30783 Hs 115263 epiregulm pane, cdon, blad mAb+diag
422397 AJ223366 Hs 116051 MYEOV Myeloma overexpressed gene (in a s pane, stom, ∞lon, esoph, renal, blad CTL+s m
422424 AI186431 Hs 296638 prostate differendadon fxtor blad, pane, pros, angio, ∞lon, stom, lung, mela diag
422627 BE336857 Hs 118787 transforming growth fxtor, beta-induced colon, renal mAb+diag
422765 AW409701 Hs 1578 bxuloviral IAP repeat-∞ntaining 5 (sur lung blad s m
422809 AK001379 Hs 121028 hypothetical protein FU 10549 blad, cer, lung, uter, angio, stom, test s m
422867 L32137 Hs 1584 cartilage oligomenc matπx protein (pse breast ova, pros, pane, lung, colon, uter diag
422956 BE545072 Hs 122579 ECT2 protein (Epithelial ∞ll Iraπsformi ova, blad, pane , lung, headnk, colon, stom CTL+s m
423161 AL049227 Hs 124776 downstream of cadheπn 6 (by 3 3kb) renal, ovar, Wad mAb+s m 423184 NM 004428 Hs 1624 ephπn-A1 pros, pane, renal mAb+s m
423242 AL039402 Hs 125783 DEME-6 protein breast renal, ovar, pros, ∞lon CTL
423422 AC005175 Hs 128425 NY-REN-24 antigen glio mAb
423508 AW604297 Hs 129711 hepadds A virus cellular rxeptor 1 renal, colon mAb
423583 AL122055 Hs 129836 KIAA1028 protein pros s m
423634 AW959908 Hs 1690 hepaπn-binding growth fxtor binding pr lung, blad, headnk, pane diag
423673 BE003054 Hs 1695 matnx metalloproteinase 12 (macrophage blad, lung, headnk, ova, pane, ∞lon, stom, uter, ∞rv, esoph, test mAb+diag+s m
423936 U77629 Hs 135639 xhaete-scute ∞mplex (Drosophila) homd ∞lon, stom, ova CTL
423961 D13666 Hs 136348 penosdn (OSF-2os) breast, ∞lon, Wad, lung, fibro, pane, headnk, ova, mela mAb+diag
424008 R02740 Hs 137555 putadve chemokine rxeptor, GTP-binding Wad, headnk, stom, cerv, esoph mAb+s m
424046 AF027866 Hs 138202 senne (or cysteine) proteinase inhibito headnk, lung, cerv diag
424252 AK000520 Hs 143811 hypothedcal protein FU20513 ∞lon, stom mAb+s m +CTL
424321 W74048 Hs 1765 tymphocyte-spxific protein tyrosine km mela, fibro s m
424381 AA285249 Hs 146329 protein kinase Chk2 (CHEK2) lung, colon, test sm
424411 NM 005209 Hs 146549 ciystallm, beta A2 pane s m
424502 AF242388 Hs 149585 lengsin lung s m
424503 NM 002205 Hs 149609 integnn, alpha 5 (fibronectin rxeptor, pane, pros, angio, blad, lung mAb+s m
424620 AA101043 Hs 151254 kallikrein 7 (chymohypdc, stratum com ovar diag
424687 J05070 Hs 151738 matrix metalloproteinase 9 (geladnase B headnk, pane, lung, blad, uter, cerv, colon, stom, test, mela diag
424735 U31875 Hs 272499 short-chain al∞hol dehydrogenase family Wad, breast CTL+s m
424825 AF207069 Hs 153357 pr∞ollagen-lysine, 2-oxoglutarate 5-dιo mela CTL+s m
424905 NM.002497 Hs 153704 NIMA (never in mitosis gene a)-related k ova, blad, lung, headnk, pane, stom s m
425009 X58288 Hs 154151 protein tyrosine phosphatase, re∞ptor t renal, fibro mAb+s m
425071 NM 013989 Hs 154424 deiodmase, lodothyronme, type II pros, ∞lon, stom, uter, cerv, headnk, esoph, pane diag
425088 AA663372 Hs 169395 hypothedcal protein FU12015 glio, mela mAb+s m +CTL
425115 R44664 Hs 123956 downstream of G protein-coupled re∞pt glio mAb+s m
425247 NM 005940 Hs 155324 matnx metalloproteinase 11 (stromelysin breast ovar, lung, colon, pane, headnk, stom, uter, cerv, blad, esoph mAb+diag+s m
425322 U63630 Hs 155637 protein kinase, DNA-xdvated, catalytic lung, headnk s m
425535 AB007937 Hs 158287 syndxan 3 mela, glio mAb+s m
425650 NM 001944 Hs 1925 desmoglem 3 (pemphigus vulgaris andgen lung, headnk, ∞rv, esoph, blad mAb
425721 AC002115 Hs 159309 uroplakin 1A blad mAb
425723 NM 014420 Hs 159311 dickkopf (Xenopus laevis) homolog 4 endo, uter, colon CTL+diag
425734 AF056209 Hs 159396 pepddylglycine alpha-amidadng monooxyg lung s m
425776 U25128 Hs 159499 parathyroid hormone rxeptor 2 ovar, uter, lung mAb+diag
425842 AI587490 Hs 159623 NK-2 (Drosophila) homolog B pane, glio s m
425852 AK001504 Hs 159651 death re∞ptor 6, TNF superfamily member blad, lung, headnk mAb+s m
425883 AL137708 Hs 161031 Homo sapiens mRNA, cDNA DKFZp434K0322 (f blad, pane mAb
425921 NM 007231 Hs 162211 solute earner family 6 (neurotransmitte stom, pane mAb+s m
425998 AU076629 Hs 165950 fibroblast growth fxtor re∞ptor 4 renal mAb+s m
426028 NM.001110 Hs 172028 a dismtegnn and metalloproteinase doma blad mAb+diag
426215 AW963419 Hs 155223 stannixalcin 2 breast lung, renal ∞lon, ovar, uter mAb+diag
426227 U67058 Hs 154299 Human proteinase xdvated re∞ptor-2 mR pane, lung, colon, esoph, stom mAb+s m
426322 J05068 Hs 2012 franscobalamin I (vitamin B12 binding pr pane, blad, stom diag
426344 H41821 Hs 322469 transcnpdonal xdvator of the c-fos p glio CTL+s m
426427 M86699 Hs 169840 TTK protein kinase ovar, lung, headnk cerv, colon, uter, stom, test CTL+s
426451 AI908165 Hs 169946 GATA-bindmg protein 3 (T-cell rxeptor blad, breast s m
426514 BE616633 Hs 170195 bone morphogenedc protein 7 (osteogenic ovar, colon, blad, lung, ∞rv mAb+diag
426600 NM 003378 Hs 171014 VGF nerve growth fxtor inducible mela diag
426761 AI0?5709 Hs 172089 PORIMIN Pro-oncosis receptor inducing me lung, esoph, pros, uter, pane, colon, ova, headnk mAb+s m
426812 AF105365 Hs 172613 solute earner family 12 (potassium/chlo renal mAb+s m
426890 AA393167 Hs 41294 ESTs renal, colon, ovar, uter, stom CTL
427239 BE270447 Hs 356512 ubiquitin caner protein lung, blad, test, mela CTL+s m
427335 AA448542 Hs 251677 G antigen 7B lung, headnk, blad mela, esoph CTL
427343 AI880044 Hs 176977 protein kinase C binding protein 2 glio CTL+s m
427722 AK000123 Hs 180479 hypothetical protein FU20116 ∞lon, stom, pane CTL
427747 AW411425 Hs 180655 seπne/threonine kinase 12 blad, lung ova, stom, test, esoph s m
427923 AW274357 Hs 301406 FGENESH predicted 11 TM protein mela mAb
427969 NM 001963 i Hs 2230 epidermal growth fxtor (beta-urogastron pane mAb+diag
428093 AW594506 Hs 104830 ESTs ovar, pane CTL
428141 D5O402 Hs 182611 solute earner family 11 (proton-coupled glio mAb+s m
428179 AI127772 Hs 279696 serum/gluco∞rticoid regulated kinase-li breast s m
428187 AI687303 Hs 285529 G protein-coupled receptor 49 ova, uter, ∞lon, stom mAb+s m
428242 H55709 Hs 2250 leukemia inhibitory fxtor (cholmergic ovar, pane, , lung diag
428296 NM 003056 I Hs 183572 solute caner family 22 (organic ∞don renal mAb+s m
428330 L22524 Hs 2256 matπx metalloproteinase 7 (matπlysm, uter, ova, fibro, pros, pane, lung, blad, headnk, esoph, mela, stom mAb+diag+s m
428368 BE440042 Hs 83326 matnx metalloproteinase 3 (stromelysin headnk, stom, esoph, ∞lon diag
428392 H10233 Hs 2265 sxretory granule, neuroendxπne protei pane diag
428450 NM 014791 Hs 184339 KIAA0175 gene product ovar, ∞rv, pane, lung Wad, mela s m
428479 Y00272 Hs 334562 ∞ll division cycle 2, G1 to S and G2 to lung, blad, colon, uter, ovar s m
428484 AF104032 Hs 184601 solute earner family 7 (cadonic ammo lung, blad, headnk, ∞rv, esoph, glio, uter, stom, colon, mela mAb+s m
428486 AW583497 Hs 184604 pancreatic polypeptide pane diag
428505 AL035461 Hs 2281 chromogranin B (sxretogranin 1) pane, lung diag
428513 BE220806 Hs 184697 plexm C1 mela pane stom, headnk mAb
428579 NM.005756 Hs 184942 G protem-∞upled rxeptor 64 ovar, EWS, uter mAb+s
428664 AK001666 Hs 189095 similar to SALL1 (sal (Drosophιla)-lιke blad, ova, pros, lung stom, test CTL+s m
428698 AA852773 Hs 334838 KIAA1866 protein breast ∞lon, lung, pane, stom, headnk, ova, EWS mAb
428748 AW593206 Hs 98785 Ksp37 protein lung diag
428758 AA433988 Hs 98502 CA125 antigen, mucin 16 ovar, cerv, lung pane stom, renal diag
428778 AK000530 Hs 193326 fibroblast growth fxtor rxeptor-hke 1 ovar mAb+s m
428784 Y12851 Hs 193470 puπnergic re∞ptor P2X, ligand-gated 10 glio, mela mAb+s m
428841 AI418430 Hs 104935 ESTs renal mAb+s m +CTL
428953 AA306610 Hs 348183 tumor nxrosis fxtor rxeptor superfami ∞rv, pane, colon, stom, headnk, renal mAb+diag
428969 AF120274 Hs 194689 artemin lung, cerv diag 428970 BE276891 Hs 194691 retinoic xid induct 3 (RAIG1) metabo stom, pane, ∞lon, ovar mAb+s m
429149 AW193360 Hs 197962 Homolog of mouse ADP-nbosylation fxtor glio mAb+s m
429211 AF052693 Hs 198249 gap junction protein, beta 5 (connexin 3 lung blad, headnk, cerv esoph, stom, mela mAb+s m
429263 AA019004 Hs 198396 ATP-bmding cassette, sub-family A (ABC1 lung mAb+s m
429276 AF056085 Hs 198612 G protem-∞upled rxeptor 51 angio, blad, glio mAb+s m
429353 AL117406 Hs 335891 ATP-bindmg cassette transporter MRP8 breast pros mAb+s m
429547 AW0O9166 Hs 99376 FGENESH predicted novd sxreted protein pane, headnk, lung, ovar diag
429610 AB024937 Hs 211092 LUNX protein, PLUNC (palate lung and nas lung, fibro mAb+diag
429903 AL134197 Hs 93597 cyclin-dependent kinase 5, regulatory su lung, mela s m
429910 NM.000867 Hs 2507 5hydroxyfryptamιne (serotonin) rxeptor leio mAb+s m
430147 R60~704 Hs 234434 hary/enhancer-of-split related with YRP glio s m
430280 AA361258 Hs 237868 interieukin 7 rxeptor mela, lung, pane, stom, esoph, headnk mAb+s m +CTL
430377 NM 001922 Hs 301865 dopxhrome tautomerase (dopxhrome delta mela CTL
430486 BE062109 Hs 241551 chlonde channel, calcium xdvated, fam lung, blad, headnk, ∞rv, esoph mAb+s m
430822 AJ005371 Hs 248017 gly∞raldehyde-3-phxphate dehydrogenase mela s m
430890 X54232 Hs 2699 glypican 1 glio, lung cerv, Wad, esoph mAb+s
431053 S40369 Hs 249141 Glutamate re∞ptor subunit glio mAb
431130 NM 006103 Hs 2719 HE4, epididymis-spxific, whey-xidic pr ova, uter diag
431462 AW583672 Hs 256311 granin-like neuroendxπne pepdde precu pane, lung, glio, test diag
431515 NM 012152 Hs 258583 EDG-7 (endothelial differendadon. lys ova, pros, lung. Wad mAb+s m
431620 AA126109 Hs 264981 2-5'-olιgoadenylate synthetase 2 (6571 esoph, ∞rv CTL+s m
431629 AU077025 Hs 265827 interferon, alpha-induαble protein (do pane, uter, cerv, stom, esoph, mela mAb+diag
431630 NM 002204 Hs 265829 integnn, alpha 3 (antigen CD49C, alpha ova, pane, blad, headnk, mela, renal mAb+s m
431840 AA534908 Hs 2860 POU doman, dass 5, transcnpdon fxto test renal. Wad CTL
431846 BE019924 Hs 271580 uroplakin 1B lung, Wad, headnk, uter, ∞rv, stom, ova mAb+diag
431870 AW449902 Hs 105500 ESTs renal mAb+s m +CTL
431939 AW008061 Hs 231994 ESTs renal, cdon mAb+s m +CTL
431958 X63629 Hs 2877 cadheπn 3, type 1 , P-cadhenn (plxenta lung, blad, ceiv, headnk, ovar, colon, pros, pane, breast esoph, test, mei; i mAb+diag
432196 AW300888 Hs 273230 hypothedcal protein FU10830 renal CTL
432201 AI538613 Hs 298241 Transmembrane protease, senne 3 breast ∞lon, ova, stom, pane, uter, ∞rv, lung mAb+diag+s m
432579 AF043244 Hs 278439 nucleolar protein 3 (apoptosis repressor renal CTL
432596 AJ224741 Hs 278461 matπlin 3 pane, breast diag
432606 NM 002104 Hs 3066 granzyme K (senne protease, granzyme 3, renal, breast lung stom, hepC, fibro CTL
432800 BE391046 Hs 278962 AIM-1 protein mela, pros mAb+s m
432829 W60377 Hs 57772 ESTs blad CTL+s m
432867 AW016936 Hs 233364 ESTs stom, colon mAb+s m +CTL
432874 W94322 Hs 279651 melanoma inhibitory activity pane, stom, mela diag
432990 AL036071 Hs 279899 tumor nxrosis fxtor re∞ptor superfami pros, renal mAb+s m
433001 AF217513 Hs 279905 clone HQ0310PRO0310p1 ∞lon, breast lung blad, cerv, uter, test, mela s m
433447 U29195 Hs 3281 neuronal penfraxin II mela, esoph, colon, renal diag
433848 AF095719 Hs 93764 ∞rboxypepddase A4 headnk, esoph, lung s m
433867 AK000596 Hs 3618 hippxalcm-like 1 renal CTL
434206 AW136973 Hs 362915 ESTs, Weakly similar to S69890 mitogen i stom, colon CTL+s m
434276 AF123659 Hs 93605 leucine zipper, putative tumor suppresso mela s m
435013 H91923 Hs 110024 NM.020142 Homo sapiens NADH ubiqumone ι α renal, lung CTL
435472 AW972330 Hs 283022 toggeππg rxeptor expressed on myeloid glio mAb
435505 AF200492 Hs 211238 ιnterieukιπ-1 homolog 1 lung, headnk diag
435869 AF255910 Hs 54650 junctional adhesion molxule 2 angio, glio mAb
436456 AW292677 Hs 248122 melan -∞n∞nfradng hormone rxeptor ( mela, glio mAb+s m
436480 AJ271643 Hs 87469 putative xid-sensmg ion channel glio mAb+s m
436481 AA379597 Hs 5199 HSPC150 protein similar to ubiquitin-con lung, Wad, colon, ovar, uter, headnk, test s m
436576 AI458213 Hs 77542 ESTs renal, pane headnk, lung mAb+s m
436608 AA628980 Hs 192371 down syndrome critical region protein DS blad, lung CTL+s m
436895 AF037335 Hs 5338 carbonic anhydrase XII breast, renal, ovar, glio mAb+s m
436961 AW375974 Hs 156704 ESTs lung, pane, renal, uter, ∞lon CTL
436982 AB018305 Hs 5378 spondm 1, (f-spondin) extrxellular mat ova, fibro diag
437016 AU076916 Hs 5398 guanine monphosphate synthetase lung, blad, cerv, esoph, headnk s m
437044 AL035864 Hs 69517 differentially expressed in Fancom's an headnk, ∞rv, lung, Wad, breast pros, ovar, stom, esoph CTL
437100 AI761073 Hs 14535 Homo sapiens cDNA FU22314 fis, clone H pane, renal mAb+s m +CTL
437212 AI765021 Hs 210775 ESTs renal, uter, ova mAb+s m +CTL
437789 AI581344 Hs 127812 ESTs, Weakly similar to T17330 hypothed lung CTL
437852 BE0O1836 Hs 256897 putative GPCR Wad, lung mAb+s m
437938 AI950087 Hs 369628 gb wq05c02 x1 NCI_CGAP.Kιd12 Homo sapien renal, ova, uter, cerv, Wad, renal mAb+s m +CTL
438380 T06430 Hs 6194 chondroidn sulfate proteoglycan BEHAB b glio, mela diag
438549 BE386801 Hs 21858 tonucleodde repeat containing 3 mela CTL+diag
438859 AI559626 Hs 93522 Homo sapiens mRNA for KIAA1647 protein, renal mAb+s m +CTL
438929 AW195515 Hs 253177 ESTs renal mAb+s m +CTL
438966 AW979074 gb EST391184 MAGE resequences MAGP Ho renal mAb+s m +CTL
439018 AW300887 Hs 26638 membrane-spanning 4-domaιns, subfamily A uter, stom, pros, fibro mAb
439223 AW238299 Hs 250618 UL16 binding protein 2 lung, headnk, cerv, esoph. Wad, ∞lon mAb
439477 W69813 Hs 58042 ESTs, Moderately simila to GFR3.HUMAN G lung mAb+s m
439569 AW602166 Hs 222399 CEGP1 protein breast AWPC, pros, blad diag
439606 W79123 Hs 58561 G protein-∞uplx' rxeptor 87 lung, blad headnk cerv, esoph mAb+s m
439738 BE246502 Hs 9598 sema domain, immunoglobulin domain (Ig), blad lung, cerv, renal mAb+s m
439759 AL359055 Hs 67709 Homo sapiens mRNA full length insert cDN ∞lon, stom, pane, lung mAb+s m +CTL
439979 AW600291 Hs 6823 hypothetical protein FLJ 10430 renal, cerv pros, headnk, colon, test mAb
440006 AK000517 Hs 6844 NALP2 protein, PYRIN-Contaming APAF1 Ii blad, ova, lung, headnk, test s m
440065 W03476 Hs 266331 Homo sapiens Fc rxeptor homolog express mela diag
440225 BE295782 Hs 159 tumor nxrosis fxtor rxeptor superfami glio mAb
440304 BE159984 Hs 125395 hepadds A virus cellular rxeptor 1 renal colon, blad mAb+s
440311 AI733079 Hs 125407 ESTs, Moderately similar to ALUE.HUMAN ι renal mAb+s m +CTL
440516 S42303 Hs 161 cadheπn 2, type 1 , N-cadheπn (neuronal glio, ova, uter, renal, hepC mAb+diag
440672 AF083811 Hs 7345 MAD1 (mitodc arest deficient, yeast, h mela s m 441362 BE614410 Hs 23044 RAD51 (S ∞revisiae) homolog (E coli Re lung, blad, headnk, test, mela, esoph s m
441392 AW451831 Hs 222119 ESTs, Weakly similar to S30433 keradn 1 renal mAb+s m +CTL
442006 AW975183 Hs 372210 ESTs, Weakly similar to S72482 hypothed fibro, angio mAb
442117 AW664964 Hs 128899 ESTs, hypothetical protein for IMAGE 447 breast, lung, blad, pane, headnk stom, ovar, pros mAb+s m
442133 AW874138 Hs 129017 ESTs, type la transmembrane protein ovar, uter mAb
442438 AA995998 gb os26b03 s1 NCI.CGAP.Kιd5 Homo sapiens uter, ovar, renal mAb+s m +CTL
443105 X96753 Hs 9004 chondroidn sulfate proteoglycan 4 (mela mela mAb+diag
443211 AI128388 Hs 143655 ESTs blad, ova, lung headnk, stom mAb+s m +CTL
443247 BE614387 Hs 333893 c-Myc target JP01 ∞lon, lung, blad, pane CTL
443426 AF098158 Hs 9329 chromosome 20 open reading frame 1 ∞lon, lung, Wad, stom, test, mela CTL
443595 AF169312 Hs 9613 PPAR(gamma) angiopoiedn related protem renal diag
443646 AI085198 Hs 164226 Thrombospondin 1 angio, pane, uter diag
443785 AW449952 Hs 190125 basic-helix-toop-helix-PAS protein glio, uter, ova mAb+s m +CTL
443859 NM.013409 Hs9914 follistadn lung, cerv, headnk, blad, esoph diag
443987 AW163123 Hs 10071 seven transmembrane protein TM7SF3 renal mAb+s m
444006 8E395085 Hs 10086 type I transmembrane protein Fn14 pane, colon, lung, ova, renal, esoph, mela, Wad, stom, cerv mAb
444371 BE540274 Hs 239 forkhead box M1 lung, headnk, blad, glio, test mela s m
444381 BE387335 Hs 283713 hypothedcal protein BC014245 breast, colon, Wad, lung pane, headnk, ova, stom, uter, renal, angio, test mela, esoph diag
444488 AW192879 Hs 355660 ancient ∞nserved domain protein 4 renal mAb+s m
444527 NM 005408 Hs 11383 small inducible cytokine subfamily A (Cy fibro, esoph diag
444781 NM 014400 Hs 11950 GPI-anchored metastasis-associated prote lung, Wad, headnk, ∞rv mAb+diag
444783 AK001468 Hs 62180 anillin (Drosophila Scraps homdog), xt ovar, lung, Wad, headnk, pane, ∞rv, stom, uter, ∞lon, esoph CTL+s m
444809 BE207568 Hs 208219 xulospanin mela mAb+s m
445070 NM.000677 Hs 258 adenosine A3 receptor glio, renal mAb+s m
445417 AK001058 Hs 12680 a dismtegnn like and metalloproteaεe w pane, headnk, stom, lung esoph diag
445537 AJ245671 Hs 12844 EGF-like-doman, multiple 6 ovar, blad, uter, breast lung, headnk, renal, fibro, pane, ∞rv mAb+diag
445891 AW391342 Hs 199460 DPCR1 protein stom, pane, esoph, omx, esoph mAb
445895 D29954 Hs 13421 KIAA0056 protein pros CTL
446051 BE048061 Hs 37054 ephnn-A3 ∞lon, breast mAb+diag
446163 AA026880 Hs 25252 prolactm re∞ptor breast ∞rv, uter mAb+s m
446232 AI281848 Hs 194691 retinoic xid induced 3 stom, pane, ∞lon, ovar mAb+s m
446341 AL040763 Hs 310735 FGENESH predicdon similar to mulddrug mela mAb+s m
446619 AU076643 Hs 313 sxreted phosphoprotein 1 (osteopontin, ovar, fibro, pane, headnk, lung, colon, blad, mela, esoph, uter diag
446650 AB016625 Hs 15813 solute earner family 22 (organic cadon renal mAb+s m
446921 AB012113 Hs 16530 small inducible cytokine subfamily A (Cy breast pane, headnk, lung, fibro, mela diag
447004 AW296968 Hs 157539 FGENESH predicted sxreted protein glio mAb+diag
447033 AI357412 Hs 157601 Predicted gene Eos cloned, sxreted w/V ∞lon, pros, fibro, breast, ova, lung, pane CTL+diag
447072 D61594 Hs 17279 tyrosylprotem sulfotransferase 1 glio, pane CTL+s m
447131 NM 004585 Hs 17466 retinoic xid rxeptor responder (tazaro renal, breast, stom, lung, mela, ovar mAb+s m
447208 BE315291 Hs 237971 hypothetical protein MGC5627 esoph, stom, colon CTL+diag
447269 NM.004861 Hs 17958 cerebroside (3' phosphoadenylylsulfate g renal CTL
447342 AI199268 Hs 19322 Homo sapiens, Simila to RIKEN cDNA 2010 ∞lon, blad, pros, lung, stom, AWPC, ovar CTL
447400 AK000322 Hs 18457 hypothedcal protein FU20315 ∞loπ, pros, stom, uter CTL
447674 BE270640 Hs 19192 cyclm-depeπdent kinase 2 mela s m
447835 AW591623 Hs 164129 ESTs Weakly similar to I38022 hypotheti renal, ovar, uter mAb+s m +CTL
447937 AL109716 Hs 20034 Homo sapiens mRNA full length insert cDN mela mAb+s
448105 AW591433 Hs 298241 Transmembrane protease, senne 3 breast, pane, ∞lon, lung, ova, stom mAb+s m +CTL
448243 AW369771 Hs 367688 integnn, beta 8 ovar, uter, lung, stom, headnk, glio, pane mAb+s m
448321 NM 005883 Hs 20912 adenomatous polyposis coli like glio mAb+s m +CTL
448499 BE613280 Hs 77550 p55regulated DDA3 glio CTL+s m
448595 AB014544 Hs 21572 KIAA0644 gene product breast glio mAb+s m
448610 NM.006157 Hs 21602 nel (chιcken)-lιke 1 mela diag
448733 NM 005629 I Hs 187958 solute earner family 6 (πeurotransmitte lung, renal mAb+s m
448844 AI581519 Hs 177164 FGENESH predicted novel cell surfxe pr pane, lung, stom, omuc mAb+s
449048 Z45051 Hs 22920 similar to S68401 (cattle) glucose indue pane, ovar, uter, glio, headnk, lung mAb
449444 AW818436 Hs 351306 solute earner family 16 (monxarboxylic renal, pane mAb+s m
449523 NM 000579 I Hs 54443 chemokine (C-C modf) rxeptor 5 lung, pane, renal, stom, hepC, fibro, mela mAb+s m
449720 AA311152 Hs 288708 hypothedcal protein FU21562 ∞lon CTL
449722 BE280074 Hs 23960 cycl B1 headnk, blad, lung, pane, angio, test mela, esoph s m
450001 NM.001044 I Hs 406 solute earner family 6 (neurofransmitte renal mAb+s m
450375 AA009647 Hs 352537 a dismtegnn and metalloproteinase doma breast, ova, headnk, pane, lung, esoph, colon mAb+diag+s m
450531 AW301032 Hs 203800 (8C017500) Simila to hypothedcal prote ∞lon CTL
450701 H39960 Hs 288467 hypothedcal protein XP.098151 (leucme- lung, headnk, pane, breast, stom, ovar, esoph, colon mAb+diag
450726 AW204600 Hs 355462 HUMPSPBA Human pulmonary surfxtant-asso fibro, lung s m
450931 N25156 Hs 25648 tumor nxrosis fxtor rxeptor superfami lung, renal mAb+s
450983 AA305384 Hs 25740 ER01 (S cerevιsιae)-lιke blad, lung, ova, pane diag
451099 R52795 Hs 25954 interieukin 13 rxeptor, alpha 2 glio, fibro, mela mAb+s m
451310 AW250651 Hs 26213 Human DNA sequen∞ from clone RP5447F3 colon, pane CTL
451527 AF022813 Hs 26518 transmembrane 4 superfamily member 7 renal mAb
451537 R56631 Hs 26550 rednoid X rxeptor, gamma mela CTL+s m
451668 Z43948 Hs 326444 cartilage acidic protein 1 blad, ova, lung mAb+diag
451939 U80456 Hs 27311 single-minded (Drosophila) homolog 2 pros CTL
451979 F06972 Hs 27372 endothelial tyrosine kinase (Etk) (BMX), angio CTL+s
451988 AF263928 Hs 27410 papillomavirus regulatory fxtor PRF-1 renal CTL
452097 AB0O2364 Hs 27916 a disintegπn-like and metalloprotease ( ova mAb+s m +dιag
452190 H26735 Hs 91668 Homo sapiens clone PP1498 unknown mRNA breast, stom, pane mAb
452194 AI694413 Hs 373599 olfxtory rxeptor, family 2 subfamily stom, pane, renal, colon, mela, fibro mAb+s m
452203 X57522 Hs 352018 transporter 1, ATP-bmding cassette, sub ∞rv, esoph Wad stom, mela, renal mAb+s m
452281 T93500 Hs 28792 Homo sapiens CDNA FLJ11041 fis, clone PL breast headnk, pane, stom, lung, esoph, fibro diag
452355 N54926 Hs 29202 G protein-coupled rxeptor 34 glio, fibro, pane mAb+s m
452401 NM 007115 Hs 29352 tumor nxrosis fxtor, alpha-induced pro blad, breast, pane, headnk, stom lung, arth, renal, esoph diag
452431 U88879 Hs 29499 toll-like re∞ptor 3 renal, hepC mAb 452747 BE153855 Hs 61460 Ig superfamily rxeptor LNIR breast, blad lung, headnk, ova, stom, uter. pane mAb
452795 AW392555 Hs 18878 hypothedcal protein FU21620 renal, headnk, ∞lon, lung, pane mAb+s m +CTL
452838 U65011 Hs 30743 preferentially expressed antigen in mela lung, ovar, Weast, mela, test, esoph, renal CTL
452862 AW378065 Hs 8687 ADAMTS2 (a dismtegnn like and metallo headnk, breast colon, arth, lung, blad, esoph stom mAb+diag
453195 BE241876 Hs 32352 hypothedcal protein DKFZp434K1210 renal CTL
453496 AA442103 Hs 33084 solute earner family 2 (facilitated glu renal, pros mAb+s m
453642 AI370936 Hs 34074 dipepddylpepddase VI glio mAb+s m
453837 AL138387 Hs 256126 bxuloviral IAP repeat-containing 7 (liv renal, mela sm
453857 AL080235 Hs 35861 Ras-induced senescence 1 (RIS1) glio, lung, uter, headnk, ∞rv, pane, pros mAb+s m
453968 AA847843 Hs 62711 High mobility group (πonhistone chromoso lung, uter, blad, test CTL+s m
456546 AI690321 Hs 203845 KCNK15 potassium channel, subfamily K, m ovar mAb+sm
456662 NM 002448 Hs 1494 msh (Drosophila) homeo box homolog 1 (fo uter, ova CTL
456759 BE259150 Hs 127792 delta (Drosophιla)-lιke 3 glio, lung mAb+s m
457133 M54968 Hs 351221 v-Kι-ras2 Kirsten rat sarcoma 2 viral on pane s m
457489 AI693815 Hs 127179 cryptic gene pane, pros, lung diag
457561 AA331517 Hs 286055 chimeπn (chimaenn) 2 glio mAb+s m
458079 AI796870 Hs 54277 Homo sapiens similar to RIKEN cDNA 28100 mela, fibro mAb
458435 AI418718 Hs 144121 ESTs, Weakly simila to T46916 hypothed glio mAb+s m +CTL
458627 AW088642 Hs 97984 SRY (sex determining region Y)-box 17 (S ova, uter, test CTL
TABLE 66B
Pkey Unique Eos probeset idendfier number
CAT number Gene cluster number
Axession Genbank axession numbers
Pkey CAT Number Accession 409745 MH1944.5 BI030997 AA921874 AW188822 BI027862 AI347618 AI361453 AI088754 AW207491 AA077391 BG012775 BG997382 AA286833 AA150722 BI007625
BI027864 BI009100 BI006275 BI006270 BI031000 BI029864 BI006277 BI007627 BI006266 BI006991 BI006990 BI007763 BI007762 BG997377
AA150780 BI033518 BI027818 BG015789 BI033807 AA341445
438966 1242593 1 AW979074 AA834841 AA828650 442438 24590.1 AK022175AU147222AI124945AU121400 F07756AW979025AA828595AA828577 BE935573AA829588 AI743616 BE315309 BE047365AI761053
AW168960 AA833900 BG679419 BE171071 BF034368 BF754297 R61781 F08149 F07647 T77332 AA897461 AI829714 AI376820 AI809991
AW661854
TABLE 66C
Pkey Unique number ∞rrespondmg to an Ex probeset
Ref Sequen∞ sour∞ The 7 digit numbers in this column ae Genbank Idendfier (Gl) numbers "Dunham, et al * refers to the publicadon endded The DNA sequence of human chromosome 22" Dunham, et al (1999) Nature 402485495
Sfrand Indicates DNA strand from which exons were predicted NLposition Indicates nucleotide positions of predicted exons
Pkey Ref Strand Nt position
400843 9188605 Plus 58655970,76557784,8892-9023,96759807,
402075 8117407 Plus 121907-122035,122804-122921,124019-12416
402901 8894222 Minus 175425175667
404287 2326514 Plus 53134-53281
404682 9797231 Minus 40977-41150
404875 9801324 Plus 9658596732,97722-97831
404977 3738341 Minus 43081-43229
405033 7107731 Minus 142355142546
405547 1054740 Plus 124361-124520,124914-125050
406400 9256298 Plus 15551712,18752140,4252-4385,5922-6077
TABLE 67 Pkey Unique Eos probeset idendfier number ExAxn Exempla A∞ession number, Genbank accession number UnigenelD Unigene number Unigene Title Unigene gene title Seq ID No Sequen∞ Idendficadon Number linking the information in Table 67 to the sequences in Table 68
Pkey ExAccn UnigenelD Unigene Title SeqlONo
418007 M13509 Hs 83169 matπx metalloproteinase 1 (interstitial Seq ID No 1 & 199
418007 M13509 Hs 83169 matnx metalloproteinase 1 (interstitial Seq ID No 2 & 200 428368 BE440042 Hs 83326 matπx metalloproteinase 3 (stromelysin Seq ID No 3 & 201
417866 AW067903 Hs 82772 ∞llagen, type XI, alpha 1 Seq ID No 4 & 202
444381 BE387335 Hs 283713 hypothedcal protein BC014245 Seq ID No 5 & 203
452281 T93500 Hs 28792 Homo sapiens cDNA FU 11041 fis. clone PL Seq ID No 6
428698 AA852773 Hs 334838 KIAA1866 protein Seq ID No 7 & 204 452862 AW378065 Hs 8687 ADAMTS2 (a disintegπn-like and metallo Seq ID No 8 S 205
432201 AI538613 Hs 298241 Transmembrane protease, senne 3 Seq 10 No 9 & 206
434206 AW136973 Hs 362915 ESTs, Weakly similar to S69890 mitogen i Seq ID No 10 & 207
422260 AA315993 Hs 105484 regenerating gene type IV Seq ID No 11 & 208
409041 AB033025 Hs 50081 Hypothedcal protem, XP.051860 (KIAA119 Seq lD No 12& 209 443426 AF098158 Hs 9329 chromosome 20 open reading frame 1 Seq ID No 13 & 210
443211 AI128388 Hs 143655 ESTs Seq ID No 14
428664 AK001666 Hs 189095 similar to SALL1 (sal (Drosophιla)-lιke Seq ID No 15 & 211
413278 BE563085 Hs 833 interferon-stimulated protein, 15 kDa Seq ID No 16 & 212
452401 NM.007115 Hs 29352 tumor nxrosis fxtor, alpha-indu∞d pro Seq ID No 17 & 213 452401 NM.007115 Hs 29352 tumor nxrosis fxtor, alpha-induced pro Seq ID No 18 & 214
408380 AF123050 Hs 44532 diubiquidn Seq ID No 19 & 215
416209 AA236776 Hs 79078 MAD2 (mitodc arest deficient, yeast, h Seq ID No 20 & 216
409757 NM.001898 Hs 123114 cystadπ SN Seq ID No 21 & 217 425921 NM.007231 Hs 162211 solute earner family 6 (neurotransmitte Seq ID No 22 & 218
452194 AI694413 Hs 373599 olfxtory re∞ptor, family 2, subfamily Seq ID No 23 & 219
452194 AI694413 Hs 373599 olfxtor rxeptor, family 2, subfamily Seq ID No 24 & 220
444783 AK001468 Hs 62180 anillm (Drosophila Scraps homolog), xt Seq ID No 25 & 221
422956 BE545072 Hs 122579 ECT2 protein (Epithelial cell transformi Seq ID No 26 & 222
424905 NM.002497 Hs 153704 NIMA (never in mitosis gene a)-related k Seq ID No 27 & 223
415989 AI267700 Hs 351201 ESTs Seq ID No 28
415989 AI267700 Hs 351201 ESTs Seq ID No 29
424252 AK000520 Hs 143811 hypothedcal protein FU20513 Seq ID No 30 & 224
424252 AK0O0520 Hs 143811 hypothedcal protein FU20513 Seq ID No 3U 225
432867 AW016936 Hs 233364 ESTs Seq ID No 32
439759 AL359055 Hs 67709 Homo sapiens mRNA full length insert cDN Seq ID No 33
428970 BE276891 Hs 194691 retinoic xid induced 3 (RAIG1), metabo Seq ID No 34 & 226
428953 AA306610 Hs 348183 tumor nxrosis fxtor rxeptor superfami Seq ID No 35 & 227
428953 AA306610 Hs 348183 tumor nxrosis fxtor rxeptor superfami Seq ID No 36 & 228
428953 AA306610 Hs 348183 tumor nxrosis fxtor re∞ptor superfami Seq ID No 37 & 229
428953 AA306610 Hs 348183 tumor nxrosis fxtor rxeptor superfami Seq ID No 38 & 230
428953 AA306610 Hs 348183 tumor nxrosis fxtor rxeptor superfami Seq ID No 39 & 231
452203 X57522 Hs 352018 transporter 1 , ATP-bindmg cassette, sub Seq ID No 40 & 232
428330 L22524 Hs 2256 matπx metalloproteinase 7 (matnlysin, Seq ID No 41 & 233
436480 AJ271643 Hs 87469 putative xid-sensing ion channel Seq ID No 42 & 234
407603 AW955705 Hs 62604 Homo sapiens, ctone IMAGE 4299322, mRNA, Seq ID No 43 & 235
425115 R44664 Hs 123956 downstream of G protem-∞upled re∞pt Seq ID No 44 & 236
435472 AW972330 Hs 283022 tnggeπng receptor expressed on myeloid Seq ID No 45 & 237
418870 AF147204 Hs 89414 chemokine (C-X-C motif), receptor 4 (fus Seq ID No 46 & 238
415511 AI732617 Hs 182362 ESTs Seq ID No 47
440304 BE159984 Hs 125395 hepadds A vims cellular rxeptor 1 Seq ID No 48 & 239
423161 AL049227 Hs 124776 downstream of cadheπn 6 (by 33kb) Seq ID No 49 & 240
423161 AL049227 Hs 124776 downstream of cadheπn 6 (by 33kb) Seq ID No 50
410153 BE311926 Hs 15830 hypothedcal protein FU12691 Seq ID No 51 & 241
410153 BE311926 Hs 15830 hypothedcal protein FU12691 Seq ID No 52 & 242
410153 BE311926 Hs 15830 hypothedcal protein FU12691 Seq ID No 53 & 243
410153 BE311926 Hs 15830 hypothedcal protein FU12691 Seq ID No 54 & 244
436895 AF037335 Hs 5338 carbonic anhydrase XII Seq ID No 55 & 245
436895 AF037335 HS 5338 carbonic anhydrase XII Seq ID No 56 & 246
421471 U90545 Hs 327179 solute earner family 17 (sodium phospha Seq ID No 57 & 247
428296 NM.003058 Hs 183572 solute earner family 22 (organic cadon Seq ID No 58 & 248
426890 AA393167 Hs 41294 ESTs Seq ID No 59 & 249
437212 AI765021 Hs 210775 ESTs Seq ID No 60
438966 AW979074 gb EST391184 MAGE resequences, MAGP Homo Seq ID No 61
440311 AI733079 Hs 125407 ESTs, Moderately similar to ALUE.HUMAN ' Seq ID No 62
437100 AI761073 Hs 14535 Homo sapiens cDNA FU22314 fis, clone H Seq ID No 63
437100 AI761073 Hs 14535 Homo sapiens cDNA FU22314 fis, clone H Seq ID No 64
450001 NM.001044 Hs 406 solute caner family 6 (neurotransmitte Seq ID No 65 & 250
419080 AW150835 Hs 18878 hypothedcal protein FU21620 Seq ID No 66 & 251
443595 AF169312 Hs 9613 PPAR(gamma) angiopoiedπ related protein Seq ID No 67 & 252
443595 AF169312 Hs 9613 PPAR(gamma) angiopoiedn related protein Seq ID No 68
410407 X66839 Hs 63287 carbonic anhydrase IX Seq ID No 69 & 253
453496 AA442103 Hs 33084 solute earner family 2 (facilitated glu Seq ID No 70 & 254
420737 L08096 Hs 99899 CD70 , tumor nxrosis fxtor (ligand) s Seq ID No 71 & 255
439979 AW600291 Hs 6823 hypothedcal protein FLJ10430 Seq ID No 72 & 256
420789 AI670057 Hs 199882 ESTs Seq ID No 73
420789 AI670057 Hs 199882 ESTs Seq ID No 74
441392 AW451831 Hs 222119 ESTs, Weakly similar to S30433 keradn 1 Seq ID No 75 & 257
452431 U88879 Hs 29499 toll-like receptor 3 Seq ID No 76 & 258
431870 AW449902 Hs 105500 ESTs Seq ID No 77
431870 AW449902 Hs 105500 ESTs Seq ID No 78
449523 NM 000579 Hs 54443 chemokine (C-C modf) receptor 5 Seq ID No 79 & 259
409745 AA077391 gb 7B14E12 Chromosome 7 Fetal Bran cDNA Seq ID No 80
438859 AI559626 Hs 93522 Homo sapiens mRNA for KIAA1647 protem, Seq ID No 81
409637 AA323948 Hs 55407 Homo sapiens mRNA, cDNA DKFZp434K0621 (f Seq ID No 82 & 260
409637 AA323948 Hs 55407 Homo sapiens mRNA, cDNA DKFZp434K0621 (f Seq ID No 83
409348 AI401535 Hs 146090 ESTs Seq ID No 84
447269 NM.004861 Hs 17958 cerebroside (3'-phosphoadenylylsu..ate g Seq ID No 85 & 261
453195 BE241876 Hs 32352 hypothetical protein DKFZp434K1210 Seq ID No 86 & 262
428841 AI418430 Hs 104935 ESTs Seq ID No 87
428841 AI418430 Hs 104935 ESTs Seq ID No 88
428841 AI418430 Hs 104935 ESTs Seq ID No 89
409663 AI743750 Hs 98306 KIAA1862 protein Seq ID No 90 & 263
409663 AI743750 Hs 98306 KIAA1862 protein Seq ID No 91 & 264
431939 AW008061 Hs 231994 ESTs Seq ID No 92 & 265
432606 NM.002104 Hs 3066 granzyme K (senne protease, granzyme 3, Seq ID No 93 & 266
411411 AA345241 Hs 55950 ESTs Weakly simila to KIAA1330 protein Seq ID No 94 & 267
433867 AK000596 Hs 3618 hippxal n-like 1 Seq ID No 95 & 268
433867 AK000596 Hs 3618 hipp∞alcm-like 1 Seq ID No 96 & 269
437938 AI950087 Hs 369628 gb wq05c02 x1 NCI_CGAP_Kιd12 Homo sapien Seq ID No 97
432579 AF043244 Hs 278439 nucleolar protein 3 (apoptosis repressor Seq ID No 98 & 270
418526 BE019020 Hs 85838 solute earner family 16 (monxarboxylic Seq ID No 99 & 271
432196 AW300888 Hs 273230 hypothedcal protein FU10830 Seq ID No 100 & 272
432196 AW300888 Hs 273230 hypothetical protein FLJ10830 Seq ID No 101 & 273
438929 AW195515 Hs 253177 ESTs Seq ID No 102
410055 AJ250839 Hs 58241 gene for seπne/threonine protein kinase Seq ID No 103 & 274
446650 AB016625 Hs 15813 solute earner family 22 (organic cadon Seq ID No 104 & 275 426812 AF105365 Hs 172613 solute earner family 12 (potassium/chlo Seq ID No 105 & 276
447131 NM 004585 Hs 17466 retinoic xid receptor responder (tazaro Seq ID No 106 & 277
449444 AW818436 Hs 351306 solute caner family 16 (monxarboxylic Seq ID No 107 & 278
422627 BE336857 Hs 118787 transforming growth fxtor, beta-induced Seq ID No 108 & 279
444488 AW192879 Hs 355660 ancient ∞nserved doman protein 4 Seq ID No 109 & 280
450931 N25156 Hs 25648 tumor nxrosis fxtor rxeptor superfami Seq ID No 110 & 281
409220 BE243323 Hs 51233 tumor nxrosis fxtor re∞ptor superfami Seq ID No 111 & 282
409220 BE243323 Hs 51233 tumor nxrosis fxtor rxeptor superfami Seq ID No 112 & 283
425998 AU076629 Hs 165950 fibroblast growth fxtor re∞ptor 4 Seq lD No 113 & 284
425998 AU076629 Hs 165950 fibroblast growth fxtor rxeptor 4 Seq ID No 1144 285
425009 X58288 Hs 154151 protein tyrosine phosphatase, re∞ptor t Seq ID No 115 & 286
443987 AW163123 Hs 10071 seven transmembrane protein TM7SF3 Seq ID No 116 & 287
432990 AL036071 Hs 279899 tumor nxrosis fxtor rxeptor superfami Seq ID No 117 & 288
436576 AI458213 Hs77542 ESTs Seq ID No 118 & 289
451527 AF022813 Hs 26518 transmembrane 4 superfamily member 7 Seq ID No 119 & 290
448733 NM 005629 Hs 187958 solute earner family 6 (neurotransmitte Seq ID No 120 & 291
410274 AA381807 Hs 61762 hypoxia-mduciWe protein 2 Seq ID No 121 & 292
125218 H91923 Hs 110024 Empiπcally selxted from AFFX single pr Seq ID No 122 & 293
436961 AW375974 Hs 156704 ESTs Seq ID No 123
431630 NM 002204 Hs 265829 integnn, alpha 3 (andgen C049C, alpha Seq ID No 1244 294
431630 NM 002204 Hs 265829 integnn, alpha 3 (andgen CD49C, alpha Seq ID No 125 & 295
419508 AW997938 Hs90786 ATP-bmding cassette, sub-family C (CFTR Seq ID No 126 & 296
431840 AA534908 Hs2860 POU domain, class 5, franxπpdon fxto Seq ID No 127 & 297
442438 AA995998 gb os26b03 s1 NCI_CGAP_Kιd5 Homo sapiens Seq ID No 128
447835 AW591623 Hs 164129 ESTs, Weakly simila to 138022 hypothed Seq ID No 129
429276 AF056085 Hs 198612 G protein-coupled rxeptor 51 Seq ID No 130 & 298
448595 AB014544 Hs 21572 KIAA0644 gene product Seq ID No 131 & 299
440516 S42303 Hs161 cadheπn 2, type 1 , N-cadheππ (neuronal Seq ID No 132 & 300
456759 BE259150 Hs 127792 delta (Drosophιla)-lιke 3 Seq ID No 133 & 301
447004 AW296968 Hs 157539 FGENESH predicted sxreted protein Seq ID No 134 & 302
425088 AA663372 Hs 169395 hypothedcal protein FU12015 Seq ID No 135 & 303
409389 AB007979 Hs 301281 Homo sapiens mRNA, chromosome 1 spxific Seq ID No 136 & 304
448321 NM 005883 Hs20912 adenomatous polyposis cod like Seq ID No 137 & 305
426344 H41821 Hs 322469 franscnpdonal xdvator of the c-fos p Seq ID No 138 & 306
419704 AA429104 Hs 45057 ESTs Seq ID No 139 & 307
412959 D87458 Hs 75090 KIAA0282 protein Seq ID No 140 & 308
448499 BE613280 Hs 77550 p55regulated DDA3 Seq ID No 141 & 309
458435 AI418718 Hs 144121 ESTs, Weakly similar to T46916 hypothed Seq ID No 142 & 310
443785 AW449952 Hs 190125 basic-helix-loop-helix-PAS protein Seq ID No 143 & 311
427343 AI880044 Hs 176977 protein kinase C binding protein 2 Seq ID No 144 & 312
416857 AA188775 Hs 292453 FGENESH predicted TM containing protem Seq ID No 145 & 313
429149 AW193360 Hs 197962 Homolog of mouse ADP-πbosyladon fxtor Seq ID No 146 & 314
418030 BE207573 Hs 83321 neuromedin B Seq ID No 147 & 315
457561 AA331517 Hs 286055 chimeπn (chimaeπn) 2 Seq ID No 148 & 316
457561 AA331517 Hs286055 chimeπn (chimaenn) 2 Seq ID No 149 & 317
430147 R60704 Hs 234434 hary/enhaπcer-of-split related with YRP Seq ID No 150 & 318
453642 AI370936 Hs 34074 dipepddylpeptidase VI Seq ID No 151 & 319
453857 AL080235 Hs 35861 Ras-mduced senescence 1 (RIS1) Seq ID No 152 & 320
449048 Z45051 Hs 22920 similar to S68401 (catϋe) glucose indue Seq ID No 153 & 321
418506 AA084248 Hs 372651 Unknown protein for MGC 29643 (formerly Seq ID No 154 & 322
416636 N32536 Hs 42645 solute earner family 16 (monxarboxylic Seq ID No 155 & 323
421508 NM.004833 Hs 105115 absent in melanoma 2 Seq ID No 156 & 324
421379 Y15221 Hs 103982 small inducible cytokine subfamily B (Cy Seq ID No 157 & 325
428784 Y12851 Hs 193470 puπnergic re∞ptor P2X, ligand-gated Seq ID No 158 & 326
431958 X63629 Hs 2877 cadhenn 3, type 1, P-cadheπn (plxenta Seq ID No 159 & 327
417542 J04129 Hs 82269 progestagen-ass∞iated endometπal prote Seq ID No 160 & 328
418678 NM 001327 Hs 167379 cancer/tesbs andgen (NY-ESO-1) Seq ID No 161 & 329
418678 NM 001327 Hs 167379 cancer/tesds andgen (NY-ESO-1) Seq ID No 162 & 330
420208 BEf76055 Hs 95972 silver (mouse homolog) like Seq ID No 163 & 331
430377 NM 001922 Hs 301865 dopxhrome tautomerase (dopxhrome delta Seq ID No 1644 332
438549 BE386801 Hs 21858 tonucleodde repeat containing 3 Seq ID No 165 & 333
412580 AA113262 Hs 17901 similar to CABLES (Homo sapiens] Seq ID No 166 & 334
417166 AA431323 Hs 42146 Pared box protein Pax-3 Seq ID No 167 & 335
428513 BE220806 Hs 184697 plexin C1 Seq ID No 168 & 336
447937 AL109716 Hs 20034 Homo sapiens mRNA full length insert cDN Seq ID No 169 & 337
447937 AL109716 Hs 20034 Homo sapiens mRNA full length insert cDN Seq ID No 170 & 338
446341 AL040763 Hs 310735 FGENESH predicdon similar to mulddrug Seq ID No 17U 339
446341 AL040763 Hs 310735 FGENESH predicdon similar to mulddrug Seq ID No 172 & 340
458079 AI796870 Hs 54277 Homo sapiens similar to RIKEN cDNA 28100 Seq ID No 173 & 341
415668 AW957684 Hs 306814 Homo sapiens lysyl oxidase-like 4 (LOXL4 Seq ID No 174 & 342
447674 BE270640 Hs 19192 cyclin-dependent kinase 2 Seq ID No 175 & 343
447674 BE270640 Hs 19192 cyclin-dependent kinase 2 Seq ID No 176 & 344
440065 W03476 Hs 266331 Homo sapiens Fc receptor homolog express Seq ID No 177 & 345
414945 BE076358 Hs 77667 lymphxyte antigen 6 complex, Ixus E Seq ID No 178 & 346
440672 AF083811 Hs7345 MAD1 (mitodc aπest deficient, yeast, h Seq IO No 179 & 347
412609 Z48804 Hs 74124 xular albinism 1 (Nettleship-Falls) Seq ID No 180 & 348
453837 AL138387 Hs 256126 bxuloviral IAP repeat-∞ntaming 7 (hv Seq ID No 181 & 349
453837 AL138387 Hs 256126 bxuloviral IAP repeat-containing 7 (liv Seq ID No 182 & 350
434276 AF123659 Hs93605 leucine zipper, putadve tumor suppresso Seq ID No 183 & 351
408367 AK001178 Hs 44424 Homo sapiens orphan neurotransmitter tra Seq ID No 184 & 352
444809 BE207568 Hs 208219 ∞ulospanin Seq ID No 185 & 353
415929 AA724373 Hs 304950 Homo sapiens mu∞lιpιn-3 (MCOLN3) Seq ID No 186 & 354
421666 AL03525O Hs 1408 endothelin 3 Seq ID No 187 & 355 424321 W74048 Hs 1765 lymph∞yte spxific protein tyrosine km Seq ID No 188 & 356
425535 AB0O7937 Hs 158287 syndecan 3 Seq ID No 1894 357
451537 R56631 Hs 26550 retinoid X re∞ptor gamma Seq ID No 190 & 358
430280 AA361258 Hs 237868 interieukin 7 rxeptor Seq ID No 191 & 359
418064 BE387287 Hs 83384 S100 calcium-binding protein beta (neur Seq ID No 192 & 360
448610 NM 006157 Hs 21602 nel (chicken) like 1 Seq ID No 193 & 361
432800 BE391046 Hs 278962 AIM-1 protein Seq ID No 1944362
416350 AF188625 Hs 189507 phospholipase A2 group IID Seq ID No 1954 363
405545 Target Exon Seq ID No 1964 364
414812 X72755 Hs.77367 monokine induced by gamma interferon Seq ID No 1974365
432874 W94322 Hs 279651 melanoma inhibitory xdvity Seq ID No 1984 366
Table 68 lists sequexes as descnbed in Table 67
Seq ID NO 1 DNA sequence
Nucleic Acid Accession tt NM_002421 2
Coding sequence 1 1409
1 11 21 31 41 51 l l l l 1 1
ATGCACAGCT TTCCTCCACT GCTGCTGCTG CTGTTCTGGG GTGTGGTGTC ACACAGCTTC 60 CCAGCGACTC TAGAAACACA AGAGCAAGAT GTGGACTTAG TCCAGAAATA CCTGGAAAAA 120 TACTACAACC TGAAGAATGA TGGGAGGCAA GTTGAAAAGC GGAGAAATAG TGGCCCAGTG 180 GTTGAAAAAT TGAAGCAAAT GCAGGAATTC TTTGGGCTGA AAGTGACTGG GAAACCAGAT 240 GCTGAAACCC TGAAGGTGAT GAAGCAGCCC AGATGTGGAG TGCCTGATGT GGCTCAGTTT 300 GTCCTCACTG AGGGGAACCC TCGCTGGGAG CAAACACATC TGACCTACAG GATTGAAAAT 360 TACACGCCAG ATTTGCCAAG AGCAGATGTG GACCATGCCA TTGAGAAAGC CTTCCAACTC 420 TGGAGTAATG TCACACCTCT GACATTCACC AAGGTCTCTG AGGGTCAAGC AGACATCATG 480 ATATCTTTTG TCAGGGGAGA TCATCGGGAC AACTCTCCTT TTGATGGACC TGGAGGAAAT 540 CTTGCTCATG CTTTTCAACC AGGCCCAGGT ATTGGAGGGG ATGCTCATTT TGATGAAGAT 600 GAAAGGTGGA CCAACAATTT CAGAGAGTAC AACTTACATC GTGTTGCGGC TCATGAACTC 660 GGCCATTCTC TTGGACTCTC CCATTCTACT GATATCGGGG CTTTGATGTA CCCTAGCTAC 720 ACCTTCAGTG GTGATGTTCA GCTAGCTCAG GATGACATTG ATGGCATCCA AGCCATATAT 780 GGACGTTCCC AAAATCCTGT CCAGCCCATC GGCCCACAAA CCCCAAAAGC ATGTGACAGT 840 AAGCTAACCT TTGATGCTAT AACTACGATT CGGGGAGAAG TGATGTTCTT TAAAGACAGA 900 TTCTACATGC GCACAAATCC CTTCTACCCG GAAGTTGAGC TCAATTTCAT TTCTGTTTTC 960 TGGCCACAAC TGCCAAATGG GCTTGAAGCT GCTTACGAAT TTGCCGACAG AGATGAAGTC 1020 CGGTTTTTCA AAGGGAATAA GTACTGGGCT GTTCAGGGAC AGAATGTGCT ACACGGATAC 1080 CCCAAGGACA TCTACAGCTC CTTTGGCTTC CCTAGAACTG TGAAGCATAT CGATGCTGCT 1140 CTTTCTGAGG AAAACACTGG AAAAACCTAC TTCTTTGTTG CTAACAAATA CTGGAGGTAT 1200 GATGAATATA AACGATCTAT GGATCCAGGT TATCCCAAAA TGATAGCACA TGACTTTCCT 1260 GGAATTGGCC ACAAAGTTGA TGCAGTTTTC ATGAAAGATG GATTTTTCTA TTTCTTTCAT 1320 GGAACAAGAC AATACAAATT TGATCCTAAA ACGAAGAGAA TTTTGACTCT CCAGAAAGCT 1380 AATAGCTGGT TCAACTGCAG GAAAAATTAG
Seq ID NO 2 DNA sequence Nucleic Acid Accession # NM.0024 Coding sequence 1 1409 1 11 21 31 41 51
I I I 1 1 1
ATGCACAGCT TTCCTCCACT GCTGCTGCTG CTGTTCTGGG GTGTGGTGTC ACACAGCTTC 60 CCAGCGACTC TAGAAACACA AGAGCAAGAT GTGGACTTAG TCCAGAAATA CCTGGAAAAA 120 TACTACAACC TGAAGAATGA TGGGAGGCAA GTTGAAAAGC GGAGAAATAG TGGCCCAGTG 180 GTTGAAAAAT TGAAGCAAAT GCAGGAATTC TTTGGGCTGA AAGTGACTGG GAAACCAGAT 240 GCTGAAACCC TGAAGGTGAT GAAGCAGCCC AGATGTGGAG TGCCTGATGT GGCTCAGTTT 300 GTCCTCACTG AGGGGAACCC TCGCTGGGAG CAAACACATC TGACCTACAG GATTGAAAAT 360 TACACGCCAG ATTTGCCAAG AGCAGATGTG GACCATGCCA TTGAGAAAGC CTTCCAACTC 420 TGGAGTAATG TCACACCTCT GACATTCACC AAGGTCTCTG AGGGTCAAGC AGACATCATG 480 ATATCTTTTG TCAGGGGAGA TCATCGGGAC AACTCTCCTT TTGATGGACC TGGAGGAAAT 540 CTTGCTCATG CTTTTCAACC AGGCCCAGGT ATTGGAGGGG ATGCTCATTT TGATGAAGAT 600 GAAAGGTGGA CCAACAATTT CAGAGAGTAC AACTTACATC GTGTTGCGGC TCATGCCCTC 660 GGCCATTCTC TTGGACTCTC CCATTCTACT GATATCGGGG CTTTGATGTA CCCTAGCTAC 720 ACCTTCAGTG GTGATGTTCA GCTAGCTCAG GATGACATTG ATGGCATCCA AGCCATATAT 780 GGACGTTCCC AAAATCCTGT CCAGCCCATC GGCCCACAAA CCCCAAAAGC ATGTGACAGT 840 AAGCTAACCT TTGATGCTAT AACTACGATT CGGGGAGAAG TGATGTTCTT TAAAGACAGA 900 TTCTACATGC GCACAAATCC CTTCTACCCG GAAGTTGAGC TCAATTTCAT TTCTGTTTTC 960 TGGCCACAAC TGCCAAATGG GCTTGAAGCT GCTTACGAAT TTGCCGACAG AGATGAAGTC 1020 CGGTTTTTCA AAGGGAATAA GTACTGGGCT GTTCAGGGAC AGAATGTGCT ACACGGATAC 1080 CCCAAGGACA TCTACAGCTC CTTTGGCTTC CCTAGAACTG TGAAGCATAT CGATGCTGCT 1140 CTTTCTGAGG AAAACACTGG AAAAACCTAC TTCTTTGTTG CTAACAAATA CTGGAGGTAT 1200 GATGAATATA AACGATCTAT GGATCCAGGT TATCCCAAAA TGATAGCACA TGACTTTCCT 1260 GGAATTGGCC ACAAAGTTGA TGCAGTTTTC ATGAAAGATG GATTTTTCTA TTTCTTTCAT 1320 GGAACAAGAC AATACAAATT TGATCCTAAA ACGAAGAGAA TTTTGACTCT CCAGAAAGCT 1380 AATAGCTGGT TCAACTGCAG GAAAAATTAG
Seq ID NO 3 DNA sequence
Nucleic Acid Accession It NM.002422 2
Coding sequence 64 1497
1 11 21 31 41 51
I I I I I I
ACAAGGAGGC AGGCAAGACA GCAAGGCATA GAGACAACAT AGAGCTAAGT AAAGCCAGTG 60 GAAATGAAGA GTCTTCCAAT CCTACTGTTG CTGTGCGTGG CAGTTTGCTC AGCCTATCCA 120 TTGGATGGAG CTGCAAGGGG TGAGGACACC AGCATGAACC TTGTTCAGAA ATATCTAGAA 180 AACTACTACG ACCTCAAAAA AGATGTGAAA CAGTTTGTTA GGAGAAAGGA CAGTGGTCCT 240 GTTGTTAAAA AAATCCGAGA AATGCAGAAG TTCCTTGGAT TGGAGGTGAC GGGGAAGCTG 300
GACTCCGACA CTCTGGAGGT GATGCGCAAG CCCAGGTGTG GAGTTCCTGA TGTTGGTCAC 360
TTCAGAACCT TTCCTGGCAT CCCGAAGTGG AGGAAAACCC ACCTTACATA CAGGATTGTG 420
AATTATACAC CAGATTTGCC AAAAGATGCT GTTGATTCTG CTGTTGAGAA AGCTCTGAAA 480
GTCTGGGAAG AGGTGACTCC ACTCACATTC TCCAGGCTGT ATGAAGGAGA GGCTGATATA 540
ATGATCTCTT TTGCAGTTAG AGAACATGGA GACTTTTACC CTTTTGATGG ACCTGGAAAT 600
GTTTTGGCCC ATGCCTATGC CCCTGGGCCA GGGATTAATG GAGATGCCCA CTTTGATGAT 660
GATGAACAAT GGACAAAGGA TACAACAGGG ACCAATTTAT TTCTCGTTGC TGCTCATGAA 720
ATTGGCCACT CCCTGGGTCT CTTTCACTCA GCCAACACTG AAGCTTTGAT GTACCCACTC 780
TATCACTCAC TCACAGACCT GACTCGGTTC CGCCTGTCTC AAGATGATAT AAATGGCATT 840
CAGTCCCTCT ATGGACCTCC CCCTGACTCC CCTGAGACCC CCCTGGTACC CACGGAACCT 900
GTCCCTCCAG AACCTGGGAC GCCAGCCAAC TGTGATCCTG CTTTGTCCTT TGATGCTGTC 960
AGCACTCTGA GGGGAGAAAT CCTGATCTTT AAAGACAGGC ACTTTTGGCG CAAATCCCTC 1020
AGGAAGCTTG AACCTGAATT GCATTTGATC TCTTCATTTT GGCCATCTCT TCCTTCAGGC 1080
GTGGATGCCG CATATGAAGT TACTAGCAAG GACCTCGTTT TCATTTTTAA AGGAAATCAA 1140
TTCTGGGCCA TCAGAGGAAA TGAGGTACGA GCTGGATACC CAAGAGGCAT CCACACCCTA 1200
GGTTTCCCTC CAACCGTGAG GAAAATCGAT GCAGCCATTT CTGATAAGGA AAAGAACAAA 1260
ACATATTTCT TTGTAGAGGA CAAATACTGG AGATTTGATG AGAAGAGAAA TTCCATGGAG 1320
CCAGGCTTTC CCAAGCAAAT AGCTGAAGAC TTTCCAGGGA TTGACTCAAA GATTGATGCT 1380
GTTTTTGAAG AATTTGGGTT CTTTTATTTC TTTACTGGAT CTTCACAGTT GGAGTTTGAC 1440
CCAAATGCAA AGAAAGTGAC ACACACTTTG AAGAGTAACA GCTGGCTTAA TTGTTGAAAG 1500
AGATATGTAG AAGGCACAAT ATGGGCACTT TAAATGAAGC TAATAATTCT TCACCTAAGT 1560
CTCTGTGAAT TGAAATGTTC GTTTTCTCCT GCCTGTGCTG TGACTCGAGT CACACTCAAG 1620
GGAACTTGAG CGTGAATCTG TATCTTGCCG GTCATTTTTA TGTTAT ACA GGGCATTCAA 1680
ATGGGCTGCT GCTTAGCTTG CACCTTGTCA CATAGAGTGA TCTTTCCCAA GAGAAGGGGA 1740
AGCACTCGTG TGCAACAGAC AAGTGACTGT ATCTGTGTAG ACTATTTGCT TATTTAATAA 1800 AGACGATTTG TCAGTTGTTT T
Seq ID NO: 4 DNA Sequence
Nucleic Acid Accession tt : NM_0018S4
Coding sequence: 162..5582
1 11 21 31 41 51
I I I I I I
AACCATCAAA TTTAGAAGAA AAAGCCCTTT GACTTTTTCC CCCTCTCCCT CCCCAATGGC 60
TGTGTAGCAA ACATCCCTGG CGATACCTTG GAAAGGACGA AGTTGGTCTG CAGTCGCAAT 120
TTCGTGGGTT GAGTTCACAG TTGTGAGTGC GGGGCTCGGA GATGGAGCCG TGGTCCTCTA 180
GGTGGAAAAC GAAACGGTGG CTCTGGGATT TCACCGTAAC AACCCTCGCA TTGACCTTCC 240
TCTTCCAAGC TAGAGAGGTC AGAGGAGCTG CTCCAGTTGA TGTACTAAAA GCACTAGATT 300
TTCACAATTC TCCAGAGGGA ATATCAAAAA CAACGGGATT TTGCACAAAC AGAAAGAATT 360
CTAAAGGCTC AGATACTGCT TACAGAGTTT CAAAGCAAGC ACAACTCAGT GCCCCAACAA 420
AACAGTTATT TCCAGGTGGA ACTTTCCCAG AAGACTTTTC AATACTATTT ACAGTAAAAC 480
CAAAAAAAGG AATTCAGTCT TTCCTTTTAT CTATATATAA TGAGCATGGT ATTCAGCAAA 540
TTGGTGTTGA GGTTGGGAGA TCACCTGTTT TTCTGTTTGA AGACCACACT GGAAAACCTG 600 CCCCAGAAGA CTATCCCCTC TTCAGAACTG TTAACATCGC TGACGGGAAG TGGCATCGGG 660 TAGCAATCAG CGTGGAGAAG AAAACTGTGA CAATGATTGT TGATTGTAAG AAGAAAACCA 720 CGAAACCACT TGA AGAAGT GAGAGAGCAA TTGTTGATAC CAATGGAATC ACGGTTTTTG 780 GAACAAGGAT TTTGGATGAA GAAGTTTTTG AGGGGGACAT TCAGCAGTTT TTGATCACAG 840 GTGATCCCAA GGCAGCATAT GACTACTGTG AGCATTATAG TCCAGACTGT GACTCTTCAG 900 CACCCAAGGC TGCTCAAGCT CAGGAACCTC AGATAGATGA GTATGCACCA GAGGATATAA 960
TCGAATATGA CTATGAGTAT GGGGAAGCAG AGTATAAAGA GGCTGAAAGT GTAACAGAGG 1020
GACCCACTGT AACTGAGGAG ACAATAGCAC AGACGGAGGC AAACATCGTT GATGATTTTC 1080
AAGAATACAA CTATGGAACA ATGGAAAGTT ACCAGACAGA AGCTCCTAGG CATGTTTCTG 1140
GGACAAATGA GCCAAATCCA GTTGAAGAAA TATTTACTGA AGAATATCTA ACGGGAGAGG 1200
ATTATGATTC CCAGAGGAAA AATTCTGAGG ATACACTATA TGAAAACAAA GAAATAGACG 1260
GCAGGGATTC TGATCTTCTG GTAGATGGAG ATTTAGGCGA ATATGATTTT TATGAATATA 1320
AAGAATATGA AGATAAACCA ACAAGCCCCC CTAATGAAGA ATTTGGTCCA GGTGTACCAG 1380
CAGAAACTGA TATTACAGAA ACAAGCATAA ATGGCCATGG TGCATATGGA GAGAAAGGAC 1440
AGAAAGGAGA ACCAGCAGTG GTTGAGCCTG GTATGCTTGT CGAAGGACCA CCAGGACCAG 1500
CAGGACCTGC AGGTATTATG GGTCCTCCAG GTCTACAAGG CCCCACTGGA CCCCCTGGTG 1560
ACCCTGGCGA TAGGGGCCCC CCAGGACGTC CTGGCTTACC AGGGGCTGAT GGTCTACCTG 1620
GTCCTCCTGG TACTATGTTG ATGTTACCGT TCCGTTATGG TGGTGATGGT TCCAAAGGAC 1680
CAACCATCTC TGCTCAGGAA GCTCAGGCTC AAGCTATTCT TCAGCAGGCT CGGATTGCTC 1740
TGAGAGGCCC ACCTGGCCCA ATGGGTCTAA CTGGAAGACC AGGTCCTGTG GGGGGGCCTG 1800
GTTCATCTGG GGCCAAAGGT GAGAGTGGTG ATCCAGGTCC TCAGGGCCCT CGAGGCGTCC 1860
AGGGTCCCCC TGGTCCAACG GGAAAACCTG GAAAAAGGGG TCGTCCAGGT GCAGATGGAG 1920
GAAGAGGAAT GCCAGGAGAA CCTGGGGCAA AGGGAGATCG AGGGTTTGAT GGACTTCCGG 1980
GTCTGCCAGG TGACAAAGGT CACAGGGGTG AACGAGGTCC TCAAGGTCCT CCAGGTCCTC 2040
CTGGTGATGA TGGAATGAGG GGAGAAGATG GAGAAATTGG ACCAAGAGGT CTTCCAGGTG 2100
AAGCTGGCCC ACGAGGTTTG CTGGGTCCAA GGGGAACTCC AGGAGCTCCA GGGCAGCCTG 2160
GTATGGCAGG TG AGATGGC CCCCCAGGAC CAAAAGGGAA CATGGGTCCC CAAGGGGAGC 2220
CTGGGCCTCC AGGTCAACAA GGGAATCCAG GACCTCAGGG TCTTCCTGGT CCACAAGGTC 2280
CAATTGGTCC TCCTGGTGAA AAAGGACCAC AAGGAAAACC AGGACTTGCT GGACTTCCTG 2340
GTGCTGATGG GCCTCCTGGT CATCCTGGGA AAGAAGGCCA GTCTGGAGAA AAGGGGGCTC 2400
TGGGTCCCCC TGGTCCACAA GGTCCTATTG GATNNCCGGG CCCCCGGGGA GTAAAGGGAG 2460
CAGATGGTGT CAGAGGTCTC AAGGGATCTA AAGGTGAAAA GGGTGAAGAT GGTTTTCCAG 2520
GATTCAAAGG TGACATGGGT CTAAAAGGTG ACAGAGGAGA AGTTGGTCAA ATTGGCCCAA 2580
GAGGGNAAGA TGGCCCTGAA GGACCCAAAG GTCGAGCAGG CCCAACTGGA GACCCAGGTC 2640
CTTCAGGTCA AGCAGGAGAA AAGGGAAAAC TTGGAGTTCC AGGATTACCA GGATATCCAG 2700
GAAGACAAGG TCCAAAGGGT TCCACTGGAT TCCCTGGGTT TCCAGGTGCC AATGGAGAGA 2760
AAGGTGCACG GGGAGTAGCT GGCAAACCAG GCCCTCGGGG TCAGCGTGGT CCAACGGGTC 2820
CTCGAGGTTC AAGAGGTGCA AGAGGTCCCA CTGGGAAACC TGGGCCAAAG GGCACTTCAG 2880
GTGGCGATGG CCCTCCTGGC CCTCCAGGTG AAAGAGGTCC TCAAGGACCT CAGGGTCCAG 2940
TTGGATTCCC TGGACCAAAA GGCCCTCCTG GACCACCAGG AAGGATGGGC TGCCCAGGAC 3000
ACCCTGGGCA ACGTGGGGAG ACTGGATTTC AAGGCAAGAC CGGCCCTCCT GGGCCAGGGG 3060 GAGTGGTTGG ACCACAGGGA CCAACCGGTG AGACTGGTCC AATAGGGGAA CGTGGGTATC 3120
CTGGTCCTCC TGGCCCTCCT GGTGAGCAAG GTCTTCCTGG TGCTGCAGGA AAAGAAGGTG 3180
CAAAGGGTGA TCCAGGTCCT CAAGGTATCT CAGGGAAAGA TGGACCAGCA GGATTACGTG 3240
GTTTCCCAGG GGAAAGAGGT CTTCCTGGAG CTCAGGGTGC ACCTGGACTG AAAGGAGGGG 3300
AAGGTCCCCA GGGCCCACCA GGTCCAGTTG GCTCACCAGG AGAACGTGGG TCAGCAGGTA 3360
CAGCTGGCCC AATTGGTTTA CGAGGGCGCC CGGGACCTCA GGGTCCTCCT GGTCCAGCTG 3420
GAGAGAAAGG TGCTCCTGGA GAAAAAGGTC CCCAAGGGCC TGCAGGGAGA GATGGAGTTC 3480
AAGGTCCTGT TGGTCTCCCA GGGCCAGCTG GTCCTGCCGG CTCCCCTGGG GAAGACGGAG 3540
ACAAGGGTGA AATTGGTGAG CCGGGACAAA AAGGCAGCAA GGGTGGCAAG GGAGAAAATG 3600
GCCCTCCCGG TCCCCCAGGT CTTCAAGGAC CAGTTGGTGC CCCTGGAATT GCTGGAGGTG 3660
ATGGTGAACC AGGTCCTAGA GGACAGCAGG GGATGTTTGG GCAAAAAGGT GATGAGGGTG 3720
CCAGAGGCTT CCCTGGACCT CCTGGTCCAA TAGGTCTTCA GGGTCTGCCA GGCCCACCTG 3780
GTGAAAAAGG TGAAAATGGG GATGTTGGTC CATGGGGGCC ACCTGGTCCT CCAGGCCCAA 3840
GAGGCCCTCA AGGTCCCAAT GGAGCTGATG GACCACAAGG ACCCCCAGGT TCTGTTGGTT 900
CAGTTGGTGG TGTTGGAGAA AAGGGTGAAC CTGGAGAAGC AGGAAACCCA GGGCCTCCTG 3960
GGGAAGCAGG TGTAGGCGGT CCCAAAGGAG AAAGAGGAGA GAAAGGGGAA GCTGGTCCAC 4020
CTGGAGCTGC TGGACCTCCA GGTGCCAAGG GGCCGCCAGG TGATGATGGC CCTAAGGGTA 4080
ACCCGGGTCC TGTTGGTTTT CCTGGAGATC CTGGTCCTCC TGGGGAACTT GGCCCTGCAG 4140
GTCAAGATGG TGTTGGTGGT GACAAGGGTG AAGATGGAGA TCCTGGTCAA CCGGGTCCTC 4200
CTGGCCCATC TGGTGAGGCT GGCCCACCAG GTCCTCCTGG AAAACGAGGT CCTCCTGGAG 4260
CTGCAGGTGC AGAGGGAAGA CAAGGTGAAA AAGGTGCTAA GGGGGAAGCA GGTGCAGAAG 4320
GTCCTCCTGG AAAAACCGGC CCAGTCGGTC CTCAGGGACC TGCAGGAAAG CCTGGTCCAG 4380
AAGGTCTTCG GGGCATCCCT GGTCCTGTGG GAGAACAAGG TCTCCCTGGA GCTGCAGGCC 4440
AAGATGGACC ACCTGGTCCT ATGGGACCTC CTGGCTTACC TGGTCTCAAA GGTGACCCTG 4500
GCTCCAAGGG TGAAAAGGGA CATCCTGGTT TAATTGGCCT GATTGGTCCT CCAGGAGAAC 4560
AAGGGGAAAA AGGTGACCGA GGGCTCCCTG GAACTCAAGG ATCTCCAGGA GCAAAAGGGG 4620
ATGGGGGAAT TCCTGGTCCT GCTGGTCCCT TAGGTCCACC TGGTCCTCCA GGCTTACCAG 4680
GTCCTCAAGG CCCAAAGGGT AACAAAGGCT CTACTGGACC CGCTGGCCAG AAAGGTGACA 4740
GTGGTCTTCC AGGGCCTCCT GGGCCTCCAG GTCCACCTGG TGAAGTCATT CAGCCTTTAC 4800
CAATCTTGTC CTCCAAAAAA ACGAGAAGAC ATACTGAAGG CATGCAAGCA GATGCAGATG 4860
ATAATATTCT TGATTACTCG GATGGAATGG AAGAAATATT TGGTTCCCTC AATTCCCTGA 4920
AACAAGACAT CGAGCATATG AAATTTCCAA TGGGTACTCA GACCAATCCA GCCCGAACTT 4980
GTAAAGACCT GCAACTCAGC CATCCTGACT TCCCAGATGG TGAATATTGG ATTGATCCTA 5040
ACCAAGGTTG CTCAGGAGAT TCCTTCAAAG TTTACTGTAA TTTCACATCT GGTGGTGAGA 5100
CTTGCATTTA TCCAGACAAA AAATCTGAGG GAGTAAGAAT TTCATCATGG CCAAAGGAGA 5160
AACCAGGAAG TTGGTTTAGT GAATTTAAGA GGGGAAAACT GCTTTCATAC TTAGATGTTG 5220
AAGGAAATTC CATCAATATG GTGCAAATGA CATTCCTGAA ACTTCTGACT GCCTCTGCTC 5280
GGCAAAATTT CACCTACCAC TGTCATCAGT CAGCAGCCTG GTATGATGTG TCATCAGGAA 5340
GTTATGACAA AGCACTTCGC TTCCTGGGAT CAAATGATGA GGAGATGTCC TATGACAATA 5400
ATCCTTTTAT CAAAACACTG TATGATGGTT GTACGTCCAG AAAAGGCTAT GAAAAAACTG 5460
TCATTGAAAT CAATACACCA AAAATTGATC AAGTACCTAT TGTTGATGTC ATGATCAGTG 5520
ACTTTGGTGA TCAGAATCAG AAGTTCGGAT TTGAAGTTGG TCCTGTTTGT TTTCTTGGCT 5580
AAGATTAAGA CAAAGAACAT ATCAAATCAA CAGAAAATGT ACCTTGGTGC CACCAACCCA 5640
TTTTGTGCCA CATGCAAGTT TTGAATAAGG ATGTATGGAA AACAACGCTG CATATACAGG 5700
TACCATTTAG GAAATACCGA TGCCTTTGTG GGGGCAGAAT CACAGACAAA AGCTTTGAAA 5760
ATCATAAAGA TATAAGTTGG TGTGGCTAAG ATGGAAACAG GGCTGATTCT TGATTCCCAA 5820
TTCTCAACTC TCCTTTTCCT ATTTGAATTT CTTTGGTGCT GTAGAAAACA AAAAAAGAAA 5880
AATATATATT CATAAAAAAT ATGGTGCTCA TTCTCATCCA TCCAGGATGT ACTAAAACAG 5940
TGTGTTTAAT AAATTGTAAT TATTTTGTGT ACAGTTCTAT ACTGTTATCT GTGTCCATTT 6000
CCAAAACTTG CACGTGTCCC TGAATTCCGC TGACTCTAAT TTATGAGGAT GCCGAACTCT 6060
GATGGCAATA ATATATGTAT TATGAAAATG AAGTTATGAT TTCCGATGAC CCTAAGTCCC 6120 TTTCTTTGGT TAATGATGAA ATTCCTTTGT GTGTGTTT
Seq ID NO 5 DNA sequence
Nucleic Acid Access ion it XM_057014
Coding sequence 143 874
1 11 21 31 41 51
I I I I I I
GGGAGGGAGA GAGGCGCGCG GGTGAAAGGC GCATTGATGC AGCCTGCGGC GGCCTCGGAG 60
CGCGGCGGAG CCAGACGCTG ACCACGTTCC TCTCCTCGGT CTCCTCCGCC TCCAGCTCCG 120
CGCTGCCCGG CAGCCGGGAG CCATGCGACC CCAGGGCCCC GCCGCCTCCC CGCAGCGGCT 180
CCGCGGCCTC CTGCTGCTCC TGCTGCTGCA GCTGCCCGCG CCGTCGAGCG CCTCTGAGAT 240
CCCCAAGGGG AAGCAAAAGG CGCAGCTCCG GCAGAGGGAG GTGGTGGACC TGTATAATGG 300
AATGTGCTTA CAAGGGCCAG CAGGAGTGCC TGGTCGAGAC GGGAGCCCTG GGGCCAATGG 360
CATTCCGGGT ACACCTGGGA TCCCAGGTCG GGATGGATTC AAAGGAGAAA AGGGGGAATG 420
TCTGAGGGAA AGCTTTGAGG AGTCCTGGAC ACCCAACTAC AAGCAGTGTT CATGGAGTTC 480
ATTGAATTAT GGCATAGATC TTGGGAAAAT TGCGGAGTGT ACATTTACAA AGATGCGTTC 540
AAATAGTGCT CTAAGAGTTT TGTTCAGTGG CTCACTTCGG CTAAAATGCA GAAATGCATG 600
CTGTCAGCGT TGGTATTTCA CATTCAATGG AGCTGAATGT TCAGGACCTC TTCCCATTGA 660
AGCTATAATT TATTTGGACC AAGGAAGCCC TGAAATGAAT TCAACAATTA ATATTCATCG 720
CACTTCTTCT GTGGAAGGAC TTTGTGAAGG AATTGGTGCT GGATTAGTGG ATGTTGCTAT 780
CTGGGTTGGC ACTTGTTCAG ATTACCCAAA AGGAGATGCT TCTACTGGAT GGAATTCAGT 840
TTCTCGCATC ATTATTGAAG AACTACCAAA ATAAATGCTT TAATTTTCAT TTGCTACCTC 900
TTTTTTTATT ATGCCTTGGA ATGGTTCACT TAAATGACAT TTTAAATAAG TTTATGTATA 960
CATCTGAATG AAAAGCAAAG CTAAATATGT TTACAGACCA AAGTGTGATT TCACACTGTT 1020
TTTAAATCTA GCATTATTCA TTTTGCTTCA ATCAAAAGTG GTTTCAATAT TTTTTTTAGT 1080
TGGTTAGAAT ACTTTCTTCA TAGTCACATT CTCTCAACCT ATAATTTGGA ATATTGTTGT 1140
GGTCTTTTGT TTTTTCTCTT AGTATAGCAT TTTTAAAAAA ATATAAAAGC TACCAATCTT 1200
TGTACAATTT GTAAATGTTA AGAATTTTTT TTATATCTGT TAAATAAAAA TTATTTCCAA 1260 CAACCTTAAA AAAAAAAAAA AAAA
Seq ID NO 6 DNA Sequence
Nucleic Acid Access ion # Eos sequence
1 11 21 31 41 51 I I I I I I
CAGGCCGGAC CACTTGCTAT ATGTAGGCNN NNNNNNNNNN NNNNAAATAC ACTTACTGTG 60
TTCTAGAGGC AGCCCTTTCT TATGCAGAAA ATACAATACG CACTGCATGA GAAGCTTGAG 120
AGTGGATTCT AATCCAGGTC TGTCGACCTT GGATATCATG CATGTGGGAA GGTGGGTGTG 180
GTGAGAAAAG TTTTAAGGCA AGAGTAGATG GCCATGTTCA ACTTTACAAA ATTTCTTGGA 240
AAACTGGCAG TATTTTGAAC TGCATCTTCT TTGGTACCGG AACCTGCAGA AACAGTGTGA 300
GAAATTAAGT CCTGGTTCAC TGCGCAGTAG CAAAGATGGT CAAGGCCATG GAAAAAGCAG 360
AAATTTACCA AGAAAGCTGA TACCCATGTA TAGTTCCCAC TCATCTCAAA TACATCTGCT 420
ATCTTTTTAA GCTAAGTCCT AGACATATCG GGGATAACAT GGGGGTTGAT TAGTGACCAC 480
AGTTATCAGA AGCAGAGAAA TGTAATTCCA TATTTTATTT GAAACTTATT CCATATTTTA 540
ATTGGATATT GAGTGATTGG GTTATCAAAC ACCCACAAAC TTTAATTTTG TTAAATTTAT 600
ATGGCTTTGA AATAGAAGTA TAAGTTGCTA CCATTTTTTG ATAACATTGA AAGATAGTAT 660
TTTACCATCT TTAATCATCT TGGAAAATAC AAGTCCTGTG AACAACCACT CTTTCACCTA 720
GCAGCATGAG GCCAAAAGTA AAGGCTTTAA ATTATAACAT ATGGGATTCT TAGTAGTATG 780 τττττττcττ GAAACTCAGT GGCTCTATCN AACCTTACTA TCTCCTCACT CTTTCTCTAA 840
GACTAAACTC TAGGCTCTTA AAAATCTGCC CACACCAATC TTAGAAGCTC TGAAAAGAAT 900
TTGTCTTTAA ATATCTTTTA ATAGTAACAT GTATTTTATG GACCAAATTG ACATTTTCGA 960
CTATTTTTTC CAAAAAAGTC AGGTGAATTT CAGCACACTG AGTTGGGAAT TTCTTATCCC 1020
AGAAGACCAA CCAATTTCAT ATTTATTTAA GATTGATTCC ATACTCCGTT TTCAAGGAGA 1080 ATCCCTGCAG TCTCCTTAAA GGTAGAACAA ATACTTTCTA TTTTTTTTTT CACCATTGTG 1140
GGATTGGACT TTAAGAGGTG ACTCTAAAAA AACAGAGAAC AAATATGTCT CAGTTGTATT 1200
AAGCACGGAC CCATATTATC ATATTCACTT AAAAAAATGA TTTCCTGTGC ACCTTTTGGC 1260
AACTTCTCTT TTCAATGTAG GGAAAAACTT AGTCACCCTG AAAACCCACA AAATAAATAA 1320
AACTTGTAGA TGTGGGCAGA AGGTTTGGGG GTGGACATTG TATGTGTTTA AATTAAACCC 1380 TGTATCACTG AGAAGCTGTT GTATGGGTCA GAGAAAATGA ATGCTTAGAA GCTGTTCACA 1440
TCTTCAAGAG CAGAAGCAAA CCACATGTCT CAGCTATATT ATTATTTATT TTTTATGCAT 1500
AAAGTGAATC ATTTCTTCTG TATTAATTTC CAAAGGGTTT TACCCTCTAT TTAAATGCTT 1560
TGAAAAACAG TGCATTGACA ATGGGTTGAT ATTTTTCTTT AAAAGAAAAA TATAATTATG 1620
AAAGCCAAGA TAATCTGAAG CCTGTTTTAT TTTAAAACTT TTTATGTTCT GTGGTTGATG 1680 TTGTTTGTTT GTTTGTTTCT ATTTTGTTGG TTTTTTACTT TGTTTTTTGT TTTGTTTTGT 1740
TTTGTTTTGC ATACTACATG CAGTTCTTTA ACCAATGTCT GTTTGGCTAA TGTAATTAAA 1800
GTTGTTAATT TATATGAGTG CATTTCAACT ATGTCAATGG TTTCTTAATA TTTATTGTGT 1860
AGAAGTACTG GTAATTTTTT TATTTACAAT ATGTTTAAAG AGATAACAGT TTGATATGTT 1920
TTCATGTGTT TATAGCAGAA GTTATTTATT TCTATGGCAT TCCAGCGGAT ATTTTGGTGT 1980 TTGCGAGGCA TGCAGTCAAT ATTTTGTACA GTTAGTGGCC AGTATTCAGC AACGCCTGAT 2040
AGCTTCTTTG GCCTTATGTT AAATAAAAAG ACCTGTTTGG GATGTAAAAA AAAAAAAAAA 2100
AAAAAAAAAA GGAGAGCGAG GACGGGCAAA AACAGCAGAG AGGAGAAAGG AAGAGCAACA 2160
GAAAGAGAGA ACGAGAGAGG AGGAGCAGGC CAGCGAGGCG GAGGAGAGGG AAGCAAGCAG 2220
CGGGCGCGCG GCGAAGACAG GGCGCGGCGC AGCAGCAGGA GAGGGGGGGA GGCGGGCGGG 2280 ACGGGAGGGG GGGACCCGAG AGGAGCGGGA AGAGGAGGGG CGGGCAGGAA GGGCCGCGGA 2340
GGAGGGGAGG AACGAAGCGA AGCGGGGAGG AGA 2 73
Seq ID NO 7 DNA sequence Nucleic Acid Accession tt Eos sequence Coding sequence 1 5001
1 11 21 31 41 51
I I I I I I
ATGCCAGGCA CAAAACTAAC CCGAACAGGC GCCCCAGCAG ACTACAGAGT GATATTGAAG 60
ACCTCTCAAG AGGACGAATT GGATGTACCT GACGACATCA GCGTCCGGGT TATGTCATCT 120
CAGTCTGTGC TTGTGTCCTG GGTGGATCCT GTTCTGGAAA AACAGAAGAA AGTTGTTGCA 180
TCAAGACAGT ACACCGTGCG CTATCGAGAG AAGGGGGAAT TGGCCAGGTG GGATTATAAG 240
CAGATCGCTA ACAGGCGTGT GCTGATTGAG AACCTGATTC CAGACACTGT GTATGAATTT 300
GCAGTCCGTA TTTCACAGGG TGAAAGAGAT GGCAAATGGA GTACGTCAGT CTTCCAAAGA 360
ACACCAGAAT CTGCCCCTAC CACAGCTCCT GAAAACTTGA ACGTCTGGCC AGTCAATGGC 420
AAACCTACAG TTGTCGCTGC ATCTTGGGAT GCGCTACCAG AGACTGAGGG GAAAGTGAAA 480
GTCTGTCTGC TGGACACAGG ACTGTTTTCA GTTTCCTCCT TCCAACCATC TGCCAAATCA 540
TTTCAGAATA CATTCTTTCA TACGCCCCGG CTCTCAAACC ATTTGGAGCA AAGTCCCTCA 600
CCTATCCTGG AGACACTACT TCTGCCCTGG TGGATGGTCT GCAGCCTGGG GAACGCTATC 660
TTTTCAAAAT CCGGGCCACA AACAGGAGAG GCCTGGGACC TCACTCCAAA GCCTTCATTG 720
TCGCTATGCC AACAAGAATG CAGCTGTACC CAGAAGGATT TCAGTTGTCT AGCTTACCTG 780
ATCGATATCC AAACCAAACA AGTTAATAAA GATCCACAAC TGGAAGGGAG TGTTTTTGGA 840
CCATGTTTTC TTTTCTACTT CCTCACATTT ATGCTGGATA TTGGCGGCTT TTCCTTCATT 900
ATGTGCTATG AAGACCCANN TGTTTCTTCT TTGACAGGCA ATTCTTTAAA ATCTGTTGCA 960
GCCAGTAAGG CGGATGTTCA GCAGAACACG GAGGACAATG GGAAACCCGA AAAACCTGAG 1020
CCTTCCTCAC CTTCTCCCAG AGCTCCAGCT TCCTCCCAAC ACCCCTCTGT GCCTGCTTCT 1080
CCCCAAGGGA GAAATGCCAA GGACCTTCTT CTTGACTTGA AGAACAAAAT ATTGGCTAAT 1140
GGTGGGGCGC CCCGAAAACC CCAGCTTCGC GCCAAGAAGG CAGAGGAGCT GGATCTTCAG 1200
TCGACAGAAA TCACTGGGGA GGAGGAGCTG GGTTCCCGGG AGGACTCGCC CATGTCACCC 1260
TCAGACACCC AAGACCAGAA ACGGACCCTG AGGCCGCCAA GTAGACACGG CCACTCGGTG 1320
GTTGCTCCCG GCAGGACTGC AGTGAGGGCC CGGATGCCAG CGCTGCCCCG AAGGGAAGGC 1380
GTAGATAAGC CTGGCTTTTC CCTGGCCACG CAGCCCCGCC CAGGGGCGCC CCCCTCGGCT 1440
TCGGCCTCTC CTGCCCACCA CGCGTCCACC CAGGGCACCT CTCATCGTCC TTCCCTGCCT 1500
GCCAGCTTGA ATGACAACGA CTTGGTGGAC TCAGACGAAG ATGAGCGCGC TGTGGGCTCC 1560
CTCCACCCCA AGGGCGCCTT CGCCCAGCCC CGGCCAGCCC TGTCCCCCAG CCGCCAGTCC 1620
CCGTCCAGCG TTCTCCGCGA CAGAAGCTCT GTGCACCCCG GCGCAAAGCC AGCCTCGCCG 1680
GCGCGGAGGA CCCCCCATTC AGGGGCCGCA GAGGAAGATT CCAGTGCCTC AGCCCCACCC 1740
TCAAGACTTT CTCCACCCCA TGGGGGATCA TCTCGGCTGC TGCCCACCCA GCCACACCTG 1800
AGCTCTCCAC TTTCCAAGGG CGGGAAGGAT GGTGAGGACG CCCCAGCCAC CAACTCCAAT 1860
GCGCCATCAC GGTCCACCAT GTCCTCCTCC GTCTCTTCTC ATCTCTCGTC CAGGACGCAG 1920
GTCTCTGAGG GAGCGGAGGC TTCTGATGGT GAAAGCCACG GTGACGGCGA TAGGGAAGAC 1980
GGCGGAAGGC AGGCGGAGGC CACGGCCCAG ACGCTGCGGG CCCGGCCTGC CTCTGGACAC 2040
TTCCATTTGC TCAGACACAA ACCCTTTGCT GCCAACGGGA GGTCTCCAAG CAGGTTCAGC 2100
ATTGGGCGGG GACCTCGGCT GCAGCCCTCC AGCTCCCCAC AGTCGACTGT GCCCTCCCGA 2160
GCCCACCCCA GGGTTCCCTC TCACTCTGAT TCCCACCCTA AGCTTAGCTC AGGTATCCAT 2220 GGAGACGAGG AGGATGAGAA GCCGCTTCCT GCCACCGTTG TCAATGACCA CGTGCCTTCC 2280
TCCTCCAGGC AGCCCATCTC CCGGGGCTGG GAGGACTTAA GGAGAAGCCC GCAGAGAGGG 2340
GCCAGCCTGC ATCGGAAGGA ACCCATCCCA GAGAACCCCA AATCCACAGG GGCAGATACA 2 00
CATCCTCAGG GCAAGTACTC CTCCCTGGCC TCCAAGGCTC AGGATGTTCA ACAGAGCACA 2460
GACGCGGACA CGGAGGGTCA TTCTCCCAAA GCACAGCCAG GGTCCACAGA CCGCCACGCG 2520
TCCCCTGCTC GTCCTCCCGC AGCACGGTCA CAGCAGCATC CCAGTGTTCC CAGAAGGATG 2580
ACACCCGGCC GGGCCCCAGA ACAGCAGCCC CCTCCTCCCG TCGCCACGTC CCAGCACCAC 2640
CCGGGACCCC AGAGCAGAGA CGCGGGTCGG TCACCTTCCC AGCCCAGGCT CTCACTGACC 2700
CAGGCCGGGC GGCCCCGCCC CACGTCGCAG GGCCGCTCCC ACTCCTCCTC GGACCCTTAC 2760
ACGGCGAGCT CCAGAGGGAT GCTCCCCACG GCCCTCCAGA ACCAGGACGA GGATGCCCAG 2820
GGCAGCTACG ACGACGACAG CACAGAAGTC GAGGCCCAGG ATGTGCGGGC CCCCGCGCAC 2880
GCCGCGCGCG CCAAGGAGGC AGCTGCGTCC CTTCCCAAGC ACCAGCAGGT GGAGTCTCCC 2940
ACAGGCGCAG GGGCAGGTGG CGACCACAGG TCCCAGCGCG GACATGCGGC CTCCCCCGCC 3000
AGGCCCAGCC GACCCGGCGG CCCCCAGTCC CGCGCCCGGG TCCCCAGCAG GGCAGCGCCG 3060
GGGAAGTCGG AGCCTCCTTC CAAGCGGCCC CTGTCCTCCA AGTCCCAGCA GTCGGTCTCA 3120
GCCGAGGACG AGGAGGAGGA GGACGCGGGG TTTTTTAAAG GCGGGAAAGA AGACCTTCTG 3180
TCTTCCTCTG TGCCAAAGTG GCCCTCTTCC TCCACTCCCA GGGGCGGCAA AGACGCCGAT 3240
GGGAGCCTCG CCAAGGAAGA GAGGGAGCCT GCCATCGCGC TTGCCCCTCG CGGAGGGAGC 3300
CTGGCTCCTG TGAAGCGACC TCTCCCCCCA CCTCCAGGCA GCTCCCCCAG GGCCTCCCAC 3360
GTCCCTTCCC GACCGCCGCC TCGCAGCGCT GCCACCGTGA GCCCCGTCGC GGGCACCCAC 3420
CCCTGGCCGC GGTACACCAC GCGCGCCCCV CCTGGCCACT TCTCCACCAC CCCGATGCTG 3480
TCCTTGCGCC AGAGGATGAT GCATGCCAGA TTCCGTAACC CTCTCTCCCG ACAGCCTGCC 3540
AGACCCTCTT ACAGACAAGG TTATAATGGC AGACCAAATG TAGAAGGGAA AGTCCTTCCT 3600
GGTAGTAATG GAAAACCGAA TGGACAGAGA ATTATCAATG GCCCTCAAGG AACAAAGTGG 3660
GTTGTGGACC TTGATCGTGG GTTAGTATTG AATGCAGAAG GAAGGTACCT CCAAGATTCA 3720
CATGGAAATC CTCTTCGGAT TAAACTAGGA GGAGATGGTC GAACCATTGT AGATCTGGAA 3780
GGGACCCCCG TGGTGAGTCC TGACGGCCTC CCACTCTTTG GGCAGGGGCG ACATGGCACA 3840
CCTCTGGCCA ATGCCCAAGA TAAGCCAATT TTGAGTCTTG GAGGAAAGCC GCTGGTGGGC 3900
TTGGAGGTCA TCAAAAAAAC CACCCATCCC CCTACCACTA CCATGCAGCC CACCACTACT 3960
ACGACGCCCC TGCCTACCAC TACAACCCCG AGGCCCACCA CTGCCACCAC CATGCAGCCC 4020
ACCACTACTA CGACGCCCCT GCCTACCACT ACACCGAGGC CCACCACTGC CACCACCCGC 4080
CGCACGACCA CCAGGCGTCC AACAACCACA GTCCGAACCA CTACGCGGAC AACCACCACC 4140
ACCACCCCCA AACCCACCAC TCCCATCCCC ACCTGTCCCC CTGGGACCTT GGAACGGCAC 4200
GACGATGATG GCAACCTGAT AATGAGCTCC AATGGGATCC CAGAGTGCTA CGCTGAAGAA 4260
GATGAGTTCT CAGGCTTGGA GACTGACACT GCAGTACCTA CGGAAGAGGC CTACGTTATA 4320
TATGATGAAG ATTATGAATT TGAGACGTCA AGGCCACCAA CCACCACTGA GCCTTCGACC 4380
ACTGCTACCA CACCGAGGGT GATCCCAGAG GAAGGCGCCA TCAGTTCCTT TCCTGAAGAA 4440
GAATTTGATC TGGCTGGAAG GAAACGATTT GTTGCTCCTT ACGTGACGTA CCTAAATAAA 4500
GACCCATCAG CCCCGTGCTC TCTGACTGAT GCACTGGATC ACTTCCAAGT GGACAGCCTG 4560
GATGAAATCA TCCCCAATGA CCTGAAGAAG AGTGATCTGC CTCCCCAGCA TGCTCCCCGC 4620
AACATCACCG TGGTGGCCGT GGAAGGTTGC CACTCATTTG TCATTGTGGA TTGGGACAAA 4680
GCCACCCCAG GAGATTTGGT CACAGGTTAT TTGGTTTACA GTGCATCCTA TGAAGATTTC 4740
ATCAGGAACA AGTTTTCCAC TCAAGCTTCA TCAGTAACTC ACTTGCCCAT TGAGAACCTA 4800
AAGCCCAACA CGAGGTATTA TTTTAAAGTG CAAGCACAAA ATCCTCATGG CTACGGACCT 4860
ATCAGCCCTT CGGTCTCATT TGTCACCGAA TCAGATAATC CTCTGCTTGT TGTGAGGCCC 4920
CCAGGCGGTG AGCTATCTGG ATCCCATTCG CTTTCAAACA TGATCCCAGC TACACGGACT 4980
GCCATGGACG GCAATATGTG AAGCGCACGT GGTATCGAAA GTTCGTGGGA GTTGTTCTTT 5040
GTAATTCACT GAGGTATAAA ATCTACCTCA GTGACAACCT GAAAGATACA TTCTACAGCA 5100
TTGGAGACAG CTGGGGAAGA GGTGAAGACC ATTGCCAATT TGTGGATTCA CACCTTGATG 5160
GAAGAACAGG GCCTCAGTCC TATGTAGAAG CCCTCCCTAC TATTCAAGGC TACTATCGCC 5220
AGTATCGTCA GGAGCCTGTC AGGTTTGGGA ACATCGGCTT CGGAACCCCC TACTACTATG 5280
TGGGCTGGTA CGAGTGTGGG GTCTCCATCC CTGGAAAGTG GTAATCACAG GACCGTCATG 5340
CTGCAAGCTT GCCCTGCCCA GCCCCACCAA CTAAGTCGCA CTAGGGGCTG TGAGCAAAGA 5400
CAGCCAGCAT GCTCAGCCCC GCTGCCCTAG GTGCCAGGAA GGTCACAGAT GGACACTGGC 5460
CATTCTGGTC ATCTCAGTCT GGAACTCAGT CCCACTTCTT GGCCTGGACA ATGAACAGGA 5520
TTCAGTTTTG CTGTTAACTT TGCTTCTCTA CTTTTTTTTG TTTGTTTGTA ATAGCACATC 5580
CCAGAGACAT CAGAAACCAG CAACTGATTC AGTGTGATTT CCCAGACTTT TTAGGCATGA 5640
AATTCGGACA CTTCAGTATT TCCAGGAATA GCATATGCAC GCTGTTCTTG CTTCATGGAA S700
TGCTACATGC TTTCTGTTTT TCTCATTTTG GATTTCTCCA AAACTAACTG AATTTAAGCT 5760
TCAGGTCCCT TTGTATGCAG TAGAAAGGAA TTATTAAAAA CACCACCAAA GAAAATAAAT 5820
ATATCCTACT TGAAATTTAC TCTATGGACT TACCCACTGC TAGAATAAAT GTATCAAATC 5880
TTATTTGTAA ATTCTCAATT TTGATATATA TATGTATATA TGCATATACA TATCCACACT 5940
TGTCTGCAAG AATATTGATT AAAATTGCTA AATTTGTACT TGTTCACCAA AAAAAAAAAA 6000 AAAAAAA
Seq ID NO 8 DNA Sequence Nucleic Acid Accession # NM.014244 Coding sequence 1 3636
1 11 21 31 41 51 I I I I I I
ATGGATCCGC CGGCGGGAGC CGCTCGCCGC CTGCTCTGCC CCGCGCTGCT GCTGCTGCTG 60
CTGCTGCTGC CGCCGCCGCT CCTGCCGCCG CCGCCGCCGC CCGCGAACGC CAGGCTCGCC 120
GCCGCCGCCG ACCCCCCAGG CGGGCCCCTG GGGCACGGAG CGGAGCGCAT CCTGGCGGTG 180
CCCGTGCGCA CTGACGCCCA GGGCCGCTTG GTGTCCCACG TGGTGTCGGC AGCTACGTCC 240
AGAGCAGGGG TACGAGCCCG CAGGGCCGCC CCGGTCCGGA CCCCGAGCTT CCCCGGAGGC 300
AACGAGGAGG AGCCTGGCAG TCACCTCTTC TACAATGTCA CGGTCTTTGG CCGAGACCTG 360
CACCTGCGGC TGCGGCCCAA CGCCCGCCTC GTGGCGCCCG GGGCCACTAT GGAGTGGCAG 420
GGCGAGAAGG GCACCACCCG CGTGGAGCCC CTGCTCGGGA GCTGTCTCTA CGTCGGAGAC 480
GTGGCCGGCC TAGCCGAAGC CTCCTCTGTG GCGCTCAGCA ACTGCGATGG GCTGGCTGGT 540
CTGATCCGGA TGGAGGAGGA GGAGTTCTTC ATCGAACCCT TGGAGAAGGG GCTGGCGGCG 600
CAGGAGGCTG AGCAAGGCCG TGTGCATGTG GTGTATCGCC GGCCACCCAC GTCCCCTCCT 660
CTCGGGGGGC CACAGGCCCT GGACACAGGG GCCTCCCTGG ACAGCCTGGA CAGCCTCAGC 720
CGCGCCCTGG GCGTCCTAGA GGAGCACGCC AACAGCTCGA GGCGGAGGGC ACGCAGGCAT 780
GCTGCAGACG ATGACTACAA CATCGAGGTC CTGCTGGGCG TGGATGACTC TGTGGTGCAG 840 TTCCACGGGA AGGAGCACGT ACAGAAGTAC CTGCTGACAC TCATGAACAT TGTCAATGAA 900
ATCTACCATG ACGAGTCCTT GGGTGCCCAC ATCAACGTGG TCCTGGTGCG GATCATCCTC 960
CTGAGCTATG GAAAGTCCAT GAGCCTCATC GAGATCGGGA ACCCCTCTCA GAGCCTGGAG 1020
AATGTCTGCC GCTGGGCCTA CCTCCAGCAG AAGCCAGACA CGGGCCACGA TGAATACCAC 1080
GATCACGCCA TCTTCCTCAC ACGGCAGGAC TTTGGGCCTT CCGGCATGCA AGGCTATGCT 1140
CCTGTCACCG GCATGTGCCA TCCGGTCCGC AGCTGCACCC TGAACCATGA GGACGGCTTC 1200
TCCTCAGCGT TTGTGGTGGC CCATGAGACT GGCCACGTGC TGGGCATGGA GCACGACGGG 1260
CAGGGCAACC GCTGTGGCGA CGAGGTGCGG CTGGGCAGCA TCATGGCGCC CCTGGTGCAG 1320
GCCGCCTTCC ACCGCTTCCA CTGGTCCCGC TGCAGCCAGC AGGAGCTGAG CCGCTACCTG 1380
CACTCCTATG ACTGCCTGCT GGATGACCCC TTCGCCCACG ACTGGCCGGC GCTGCCCCAG 1440
CTCCCGGGAC TGCACTACTC CATGAACGAG CAATGCCGCT TTGACTTCGG CCTGGGCTAC 1500
ATGATGTGCA CGGCGTTCCG GACCTTTGAC CCCTGCAAGC AGCTGTGGTG CAGCCATCCT 1560
GACAACCCCT ACTTTTGCAA GACCAAGAAG GGGCCCCCCT TGGACGGGAC TATGTGTGCA 1620
CCTGGCAAGC ATTGTTTTAA AGGACACTGC ATCTGGCTGA CACCTGACAT CCTCAAACGG 1680
GACGGCAGCT GGGGCGCTTG GAGTCCGTTT GGCTCCTGCT CACGTACCTG TGGCACGGGC 1740
GTGAAGTTCA GGACCCCCCA GTGTGACAAC CCACACCCGG CCAACGGGGG CCGCACCTGC 1800
TCGGGCCTTG CCTACGACTT CCAGCTCTGC AGCCGCCAGG ACTGCCCCGA CTCCCTGGCT 1860
GACTTCCGCG AGGAGCAGTG CCGCCAGTGG GACCTGTACT TCGAGCACGG CGACGCCCAG 1920
CACCACTGGC TGCCCCACGA GCACCGGGAT GCCAAGGAGA GATGCCACCT GTACTGCGAG 1980
TCCAGGGAGA CCGGGGAGGT GGTGTCCATG AAGCGCATGG TGCATGATGG GACGCGCTGC 2040
TCCTACAAGG ACGCCTTCAG CCTCTGTGTG CGCGGGGACT GCAGGAAGGT GGGCTGTGAC 2100
GGTGTGATCG GCTCCAGCAA GCAGGAAGAC AAGTGTGGCG TGTGCGGAGG GGACAACAGC 2160
CACTGCAAAG TGGTCAAGGG CACGTTCACA CGGTCACCCA AGAAGCATGG TTACATCAAG 2220
ATGTTTGAGA TCCCTGCAGG AGCCAGACAC CTGCTCATTC AGGAGGTAGA CGCCACCAGC 2280
CACCATCTGG CCGTCAAGAA CCTGGAGACA GGCAAGTTCA TCTTAAATGA AGAGAATGAC 2340
GTGGATGCCA GTTCCAAAAC CTTCATTGCC ATGGGCGTGG AGTGGGAGTA CAGAGACGAG 2400
GACGGCCGGG AGACGCTGCA GACCATGGGC CCCCTCCACG GCACCATCAC CGTTCTGGTC 2460
ATCCCGGTGG GAGACACCCG GGTCTCACTG ACGTACAAAT ACATGATCCA TGAGGACTCA 2520
CTGAATGTCG ATGACAACAA CGTCCTGGAA GAGGACTCTG TGGTCTACGA GTGGGCCCTG 2580
AAGAAGTGGT CTCCGTGCTC CAAGCCCTGT GGCGGAGGGT CCCAGTTCAC CAAGTATGGC 2640
TGCCGCCGGA GGCTGGACCA CAAGATGGTA CACCGTGGCT TCTGTGCCGC CCTCTCGAAG 2700
CCCAAAGCCA TCCGCAGAGC GTGCAACCCA CAGGAATGCT CCCAGCCAGT GTGGGTCACA 2760
GGCGAATGGG AGCCATGTAG CCAGACCTGT GGGCGGACAG GCATGCAGGT GCGCTCCGTG 2820
CGCTGCATTC AGCCGCTACA CGACAACACC ACCCGCTCCG TGCACGCCAA GCACTGCAAT 2880
GACGCCCGGC CCGAGAGCCG CCGGGCCTGC AGCCGCGAGC TCTGCCCTGG TCGTTGGCGA 2940
GCCGGGCCCT GGTCCCAGTG CTCAGTAACC TGTGGCAACG GCACCCAGGA GCGGCCAGTG 3000
CCCTGCCGCA CCGCGGACGA CAGCTTCGGC ATCTGCCAGG AGGAGCGTCC TGAGACAGCG 3060
AGGACCTGCA GGCTTGGCCC CTGTCCCCGA AACATCTCAG ATCCCTCCAA GAAGAGCTAC 3120
GTAGTTCAGT GGCTGTCCCG CCCGGACCCC GACTCGCCCA TCCGGAAGAT CTCGTCAAAG 3180
GGCCACTGCC AAGGCGACAA GTCAATATTC TGTAGGATGG AAGTCTTGTC CCGCTATTGC 3240
TCCATCCCAG GCTACAACAA GCTGTCCTGC AAGTCCTGTA ACCTGTACAA CAACCTCACC 3300
AACGTGGAGG GCAGGATAGA GCCACCGCCT GGGAAGCACA ACGACATTGA CGTGTTCATG 3360
CCTACCCTCC CAGTGCCCAC TGTAGCCATG GAGGTGCGGC CATCACCAAG CACCCCCCTG 3420
GAGGTCCCTC TCAATGCCTC CAGCACCAAT GCCACAGAGG ATCACCCAGA AACCAATGCC 3480
GTAGATGAAC CCTACAAAAT CCATGGCCTG GAAGATGAAG TCCAGCCACC CAACCTAATC 3540
CCTCGACGAC CGAGCCCCTA TGAAAAGACC AGAAACCAAA GAATCCAAGA GCTCATTGAT 3600
GAGATGCGGA AGAAAGAGAT GCTCGGAAAG TTCTAA 3636
Seq ID NO 9 DNA sequence
Nucleic Acid Accession tt NM.024022
Coding sequence 202 1563
1 11 21 31 41 51
I I I I I
ACCGGGCACC GGACGGCTCG GGTACTTTCG TTCTTAATTA GGTCATGCCC GTGTGAGCCA 60 GGAAAGGGCT GTGTTTATGG GAAGCCAGTA ACACTGTGGC CTACTATCTC TTCCGTGGTG 120 CCATCTACAT TTTTGGGACT CGGGAATTAT GAGGTAGAGG TGGAGGCGGA GCCGGATGTC 180 AGAGGTCCTG AAATAGTCAC CATGGGGGAA AATGATCCGC CTGCTGTTGA AGCCCCCTTC 240 TCATTCCGAT CGCTTTTTGG CCTTGATGAT TTGAAAATAA GTCCTGTTGC ACCAGATGCA 300 GATGCTGTTG CTGCACAGAT CCTGTCACTG CTGCCATTGA AGTTTTTTCC AATCATCGTC 360 ATTGGGATCA TTGCATTGAT ATTAGCACTG GCCATTGGTC TGGGCATCCA CTTCGACTGC 420 TCAGGGAAGT ACAGATGTCG CTCATCCTTT AAGTGTATCG AGCTGATAGC TCGATGTGAC 480 GGAGTCTCGG ATTGCAAAGA CGGGGAGGAC GAGTACCGCT GTGTCCGGGT GGGTGGTCAG 540 AATGCCGTGC TCCAGGTGTT CACAGCTGCT TCGTGGAAGA CCATGTGCTC CGATGACTGG 600 AAGGGTCACT ACGCAAATGT TGCCTGTGCC CAACTGGGTT TCCCAAGCTA TGTGAGTTCA 660 GATAACCTCA GAGTGAGCTC GCTGGAGGGG CAGTTCCGGG AGGAGTTTGT GTCCATCGAT 720 CACCTCTTGC CAGATGACAA GGTGACTGCA TTACACCACT CAGTATATGT GAGGGAGGGA 780 TGTGCCTCTG GCCACGTGGT TACCTTGCAG TGCACAGCCT GTGGTCATAG AAGGGGCTAC 840 AGCTCACGCA TCGTGGGTGG AAACATGTCC TTGCTCTCGC AGTGGCCCTG GCAGGCCAGC 900 CTTCAGTTCC AGGGCTACCA CCTGTGCGGG GGCTCTGTCA TCACGCCCCT GTGGATCATC 960
ACTGCTGCAC ACTGTGTTTA TGACTTGTAC CTCCCCAAGT CATGGACCAT CCAGGTGGGT 1020
CTAGTTTCCC TGTTGGACAA TCCAGCCCCA TCCCACTTGG TGGAGAAGAT TGTCTACCAC 1080
AGCAAGTACA AGCCAAAGAG GCTGGGCAAT GACATCGCCC TTATGAAGCT GGCCGGGCCA 1140
CTCACGTTCA ATGAAATGAT CCAGCCTGTG TGCCTGCCCA ACTCTGAAGA GAACTTCCCC 1200
GATGGAAAAG TGTGCTGGAC GTCAGGATGG GGGGCCACAG AGGATGGAGG TGACGCCTCC 1260
CCTGTCCTGA ACCACGCGGC CGTCCCTTTG ATTTCCAACA AGATCTGCAA CCACAGGGAC 1320
GTGTACGGTG GCATCATCTC CCCCTCCATG CTCTGCGCGG GCTACCTGAC GGGTGGCGTG 1380
GACAGCTGCC AGGGGGACAG CGGGGGGCCC CTGGTGTGTC AAGAGAGGAG GCTGTGGAAG 1440
TTAGTGGGAG CGACCAGCTT TGGCATCGGC TGCGCAGAGG TGAACAAGCC TGGGGTGTAC 1500
ACCCGTGTCA CCTCCTTCCT GGACTGGATC CACGAGCAGA TGGAGAGAGA CCTAAAAACC 1560
TGAAGAGGAA GGGGACAAGT AGCCACCTGA GTTCCTGAGG TGATGAAGAC AGCCCGATCC 1620
TCCCCTGGAC TCCCGTGTAG GAACCTGCAC ACGAGCAGAC ACCCTTGGAG CTCTGAGTTC 1680
CGGCACCAGT AGCAGGCCCG AAAGAGGCAC CCTTCCATCT GATTCCAGCA CAACCTTCAA 1740
GCTGCTTTTT GTTTTTTGTT TTTTTGAGGT GGAGTCTCGC TCTGTTGCCC AGGCTGGAGT 1800
GCAGTGGCGA AATCCCTGCT CACTGCAGCC TCCGCTTCCC TGGTTCAAGC GATTCTCTTG 1860 CCTCAGCTTC CCCAGTAGCT GGGACCACAG GTGCCCGCCA CCACACCCAA CTAATTTTTG 1920
TATTTT AGT AGAGACAGGG TTTCACCATG TTGGCCAGGC TGCTCTCAAA CCCCTGACCT 1980
CAAATGATGT GCCTGCTTCA GCCTCCCACA GTGCTGGGAT TACAGGCATG GGCCACCACG 2040
CCTAGCCTCA CGCTCCTTTC TGATCTTCAC TAAGAACAAA AGAAGCAGCA ACTTGCAAGG 2100
GCGGCCTTTC CCACTGGTCC ATCTGGTTTT CTCTCCAGGG GTCTTGCAAA ATTCCTGACG 2160
AGATAAGCAG TTATGTGACC TCACGTGCAA AGCCACCAAC AGCCACTCAG AAAAGACGCA 2220
CCAGCCCAGA AGTGCAGAAC TGCAGTCACT GCACGTTTTC ATCTCTAGGG ACCAGAACCA 2280
AACCCACCCT TTCTACTTCC AAGACTTATT TTCACATGTG GGGAGGTTAA TCTAGGAATG 2340
ACTCGTTTAA GGCCTATTTT CATGATTTCT TTGTAGCATT TGGTGCTTGA CGTATTATTG 2400
10 TCCTTTGATT CCAAATAATA TGTTTCCTTC CCTCAAAAAA AAAAAAAAAA AAAAAAAAAA 2460 AAAAA
Seq ID NO 10 DNA Sequence Nucleic Acid Accession # AK09219S \ 5 Coding sequence 1 2034
1 11 21 31 41 51
I I I I I I
ATGCTGTCAT CCACTGACTT TACATTTGCT TCCTGGGAGC TTGTGGTCCG CGTTGACCAT 60
CCCAATGAAG AGCAGCAGAA AGACGTCACA CTGAGAGTAT CTGGAGACCT TCATGTTGGA 120
20 GGAGTGATGC TCAAGTTAGT AGAACAGATC AATATATCCC AAGACTGGTC AGACTTTGCT 180
CTTTGGTGGG AACAGAAGCA TTGCTGGCTT CTGAAAACCC ACTGGACCCT GGACAAATAT 240
GGGGTCCAGG CAGATGCAAA GCTTCTCTTC ACCCCTCAGC ATAAAATGCT GCGCCTTCGT 300
CTGCCGAATT TGAAGATGGT GAGGTTGCGA GTCAGCTTCT CAGCTGTGGT TTTTAAAGCT 360
GTCAGTGATA TCTGCAAAAT CCTGAATATT AGAAGATCAG AAGAGCTTTC CTTGTTAAAG 420
25 CCGTCTGGTG ACTATTTTAA GAAGAAGAAG AAAAAAGACA AAAATAATAA GGAACCCATA 480
ATTGAAGATA TTCTAAACCT GGAGAGTTCT CCAACAGCTT CAGGTTCATC AGTAAGTCCT 540
GGTTTATACA GTAAAACCAT GACCCCTATA TATGACCCCA TCAATGGAAC ACCAGCATCA 600
TCCACCATGA CTTGGTTCAG TGACAGCCCT TTGACGGAAC AAAACTGCAG CATCCTCGCA 660
TTCAGCCAAC CCCCCCAGTC CCCAGAAGCA CTTGCGGATA TGTACCAGCC TCGGTCTCTG 720
30 GTTGATAAAG CCAAGCTCAA TGCAGGTTGG CTAGACTCCT CACGCTCCCT TATGGAACAA 780
GGCATCCAAG AGGATGAGCA GCTGCTCTTA CGATTTAAAT ATTATTCTTT CTTCGACTTG 840
AATCCTAAAT ATGATGCTGT CCGAATAAAC CAACTCTATG AGCAAGCCAG GTGGGCCATT 900
CTCTTAGAAG AAATTGATTG CACAGAGGAA GAAATGTTGA TCTTTGCAGC TCTACAGTAC 960
CACATTAGCA AACTGTCGTT GTCTGCTGAA ACACAGGATT TTGCAGGCGA GTCCGAGGTT 1020
35 GATGAAATAG AAGCGGCGCT TTCTAATTTG GAAGTAACCC TAGAAGGTGG AAAAGCGGAC 1080
AGCCTTTTGG AGGACATTAC TGATATCCCT AAACTTGCAG ATAATCTCAA ATTATTTAGG 1140
CCCAAGAAGT TACTACCAAA AGCTTTCAAA CAATATTGGT TTATCTTTAA AGACACATCC 1200
ATAGCATACT TTAAAAATAA GGAACTTGAA CAAGGAGAAC CACTAGAAAA ACTAAATCTT 1260
AGAGGCTGCG AAGTTGTGCC CGATGTAAAT GTAGCAGGAA GAAAATTTGG AATCAAGTTA 1320
40 CTAATCCCTG TTGCCGATGG TATGAATGAA ATGTATTTGA GATGTGACCA TGAGAATCAA 1380
TACGCCCAAT GGATGGCTGC CTGCATGTTG GCATCGAAGG GCAAAACCAT GGCAGACAGC 1440
TCCTACCAGC CAGAGGTCCT CAACATCCTT TCATTTCTGA GGATGAAAAA CAGGAACTCT 1500
GCATCTCAGG TGGCTTCCAG TCTCGAAAAC ATGGATATGA ACCCAGAATG TTTTGTGTCA 1560
CCACGGTGTG CAAAAAGACA CAAATCCAAA CAGCTGGCCG CCCGGATCCT GGAGGCGCAC 1620
45 CAGAACGTGG CCCAGATGCC CCTGGTCGAA GCCAAGCTGC GGTTCATCCA GGCGTGGCAG 1680
TCACTGCCTG AGTTTGGCCT CACCTACTAC CTTGTCAGAT TTAAAGGAAG CAAAAAAGAT 17 0
GACATTCTGG GAGTTTCATA TAACAGGTTG ATTAAAATTG ATGCAGCCAC CGGGATTCCA 1800
GTGACAACAT GGAGATTCAC AAATATCAAA CAGTGGAATG TAAACTGGGA AACCCGGCAG 1860
GTGGTCATCG AGTTTGACCA AAACGTCTTT ACTGCTTTCA CCTGCCTGAG TGCAGATTGC 1920
50 AAGATTGTGC ACGAGTACAT TGGCGGCTAC ATTTTCTTGT CCACCCGCTC CAAGGACCAG 1980
AATGAAACAC TCGATGAGGA CTTGTTCCAC AAATTGACCG GCGGTCAGGA TTGA 2034
Seq ID NO 11 DNA Sequence Nucleic Acid Accession # NM_032044 Jj Coding sequence 182 658
1 11 21 31 41 51
I I I I I I
AAGATATAAA AGCTCCAGAA ACGTTGACTG GGACCACTGG AGACACTGAA GAAGGCAGGG 60
GCCCTTAGAG TCTTGGTTGC CAAACAGATT TGCAGATCAA GGAGAACCCA GGAGTTTCAA 120
60 AGAAGCGCTA GTAAGGTCTC TGAGATCCTT GCACTAGCTA CATCCTCAGG GTAGGAGGAA 180
GATGGCTTCC AGAAGCATGC GGCTGCTCCT ATTGCTGAGC TGCCTGGCCA AAACAGGAGT 240
CCTGGGTGAT ATCATCATGA GACCCAGCTG TGCTCCTGGA TGGTTTTACC ACAAGTCCAA 300
TTGCTATGGT TACTTCAGGA AGCTGAGGAA CTGGTCTGAT GCCGAGCTCG AGTGTCAGTC 360
TTACGGAAAC GGAGCCCACC TGGCATCTAT CCTGAGTTTA AAGGAAGCCA GCACCATAGC 420
65 AGAGTACATA AGTGGCTATC AGAGAAGCCA GCCGATATGG ATTGGCCTGC ACGACCCACA 480
GAAGAGGCAG CAGTGGCAGT GGATTGATGG GGCCATGTAT CTGTACAGAT CCTGGTCTGG 540
CAAGTCCATG GGTGGGAACA AGCACTGTGC TGAGATGAGC TCCAATAACA ACTTTTTAAC 600
TTGGAGCAGC AACGAATGCA ACAAGCGCCA ACACTTCCTG TGCAAGTACC GACCATAGAG 660
CAAGAATCAA GATTCTGCTA ACTCCTGCAC AGCCCCGTCC TCTTCCTTTC TGCTAGCCTG 720
70 GCTAAATCTG CTCATTATTT CAGAGGGGAA ACCTAGCAAA CTAAGAGTGA TAAGGGCCCT 780
ACTACACTGG CTTTTTTAGG CTTAGAGACA GAAACTTTAG CATTGGCCCA GTAGTGGCTT 840
CTAGCTCTAA ATGTTTGCCC CGCCATCCCT TTCCACAGTA TCCTTCTTCC CTCCTCCCCT 900
GTCTCTGGCT GTCTCGAGCA GTCTAGAAGA GTGCATCTCC AGCCTATGAA ACAGCTGGGT 960
CTTTGGCCAT AAGAAGTAAA GATTTGAAGA CAGAAGGAAG AAACTCAGGA GTAAGCTTCT 1020
75 AGACCCCTTC AGCTTCTACA CCCTTCTGCC CTCTCTCCAT TGCCTGCACC CCACCCCAGC 1080
CACTCAACTC CTGCTTGTTT TTCCTTTGGC CATAGGAAGG TTTACCAGTA GAATCCTTGC 1140
TAGGTTGATG TGGGCCATAC ATTCCTTTAA TAAACCATTG TGTACATAAG AAAAAAAAAA 1200
Seq ID NO 12 DNA Sequence 80 Nucleic Acid Accession tl XM.051860 2 Coding sequence 261 4346 1 11 21 31 41 51
I I I I I I
GAGCTAGCGC TCAAGCAGAG CCCAGCGCGG TGCTATCGGA CAGAGCCTGG CGAGCGCAAG CGGCGCGGGG AGCCAGCGGG GCTGAGCGCG GCCAGGGTCT GAACCCAGAT TTCCCAGACT 120 AGCTACCACT CCGCTTGCCC ACGCCCCGGG AGCTCGCGGC GCCTGGCGGT CAGCGACCAG 180 ACGTCCGGGG CCGCTGCGCT CCTGGCCCGC GAGGCGTGAC ACTGTCTCGG CTACAGACCC 240 AGAGGGAGCA CACTGCCAGG ATGGGAGCTG CTGGGAGGCA GGACTTCCTC TTCAAGGCCA 300 TGCTGACCAT CAGCTGGCTC ACTCTGACCT GCTTCCCTGG GGCCACATCC ACAGTGGCTG 360 CTGGGTGCCC TGACCAGAGC CCTGAGTTGC AACCCTGGAA CCCTGGCCAT GACCAAGACC 420 ACCATGTGCA TATCGGCCAG GGCAAGACAC TGCTGCTCAC CTCTTCTGCC ACGGTCTATT 480 CCATCCACAT CTCAGAGGGA GGCAAGCTGG TCATTAAAGA CCACGACGAG CCGATTGTTT 540 TGCGAACCCG GCACATCCTG ATTGACAACG GAGGAGAGCT GCATGCTGGG AGTGCCCTCT 600 GCCCTTTCCA GGGCAATTTC ACCATCATTT TGTATGGAAG GGCTGATGAA GGTATTCAGC 660 CGGATCCTTA CTATGGTCTG AAGTACATTG GGGTTGGTAA AGGAGGCGCT CTTGAGTTGC 720 ATGGACAGAA AAAGCTCTCC TGGACATTTC TGAACAAGAC CCTTCACCCA GGTGGCATGG 780 CAGAAGGAGG CTATTTTTTT GAAAGGAGCT GGGGCCACCG TGGAGTTATT GTTCATGTCA 840 TCGACCCCAA ATCAGGCACA GTCATCCATT CTGACCGGTT TGACACCTAT AGATCCAAGA 900 AAGAGAGTGA ACGTCTGGTC CAGTATTTGA ACGCGGTGCC CGATGGCAGG ATCCTTTCTG 960 TTGCAGTGAA TGATGAAGGT TCTCGAAATC TGGATGACAT GGCCAGGAAG GCGATGACCA 1020 AATTGGGAAG CAAACACTTC CTGCACCTTG GATTTAGACA CCCTTGGAGT TTTCTAACTG 1080 TGAAAGGAAA TCCATCATCT TCAGTGGAAG ACCATATTGA ATATCATGGA CATCGAGGCT 1140 CTGCTGCTGC CCGGGTATTC AAATTGTTCC AGACAGAGCA TGGCGAATAT TTCAATGTTT 1200 CTTTGTCCAG TGAGTGGGTT CAAGACGTGG AGTGGACGGA GTGGTTCGAT CATGATAAAG 1260 TATCTCAGAC TAAAGGTGGG GAGAAAATTT CAGACCTCTG GAAAGCTCAC CCAGGAAAAA 1320 TATGCAATCG TCCCATTGAT ATACAGGCCA CTACAATGGA TGGAGTTAAC CTCAGCACCG 1380 AGGTTGTCTA CAAAAAAGGC CAGGATTATA GGTTTGCTTG CTACGACCGG GGCAGAGCCT 1440 GCCGGAGCTA CCGTGTACGG TTCCTCTGTG GCAAGCCTGT GAGGCCCAAA CTCACAGTCA 1500 CCATTGACAC CAATGTGAAC AGCACCATTC TGAACTTGGA GGATAATGTA CAGTCATGGA 1560 AACCTGGAGA TACCCTGGTC ATTGCCAGTA CTGATTACTC CATGTACCAG GCAGAAGAGT 1620 TCCAGGTGCT TCCCTGCAGA TCCTGCGCCC CCAACCAGGT CAAAGTGGCA GGGAAACCAA 1680 TGTACCTGCA CATCGGGGAG GAGATAGACG GCGTGGACAT GCGGGCGGAG GTTGGGCTTC 1740 TGAGCCGGAA CATCATAGTG ATGGGGGAGA TGGAGGACAA ATGCTACCCC TACAGAAACC 1800 ACATCTGCAA TTTCTTTGAC TTCGATACCT TTGGGGGCCA CATCAAGTTT GCTCTGGGAT 1860 TTAAGGCAGC ACACTTGGAG GGCACGGAGC TGAAGCATAT GGGACAGCAG CTGGTGGGTC 1920 AGTACCCGAT TCACTTCCAC CTGGCCGGTG ATGTAGACGA AAGGGGAGGT TATGACCCAC 1980 CCACATACAT CAGGGACCTC TCCATCCATC ATACATTCTC TCGCTGCGTC ACAGTCCATG 2040 GCTCCAATGG CTTGTTGATC AAGGACGTTG TGGGCTATAA CTCTTTGGGC CACTGCTTCT 2100 TCACGGAAGA TGGGCCGGAG GAACGCAACA CTTTTGACCA CTGTCTTGGC CTCCTTGTCA 2160 AGTCTGGAAC CCTCCTCCCC TCGGACCGTG ACAGCAAGAT GTGCAAGATG ATCACAGAGG 2220 ACTCCTACCC GGGGTACATC CCCAAGCCCA GGCAAGACTG CAATGCTGTG TCCACCTTCT 2280 GGATGGCCAA TCCCAACAAC AACCTCATCA ACTGTGCCGC TGCAGGATCT GAGGAAACTG 2340 GATTTTGGTT TATTTTTCAC CACGTACCAA CGGGCCCCTC CGTGGGAATG TACTCCCCAG 2400 GTTATTCAGA GCACATTCCA CTGGGAAAAT TCTATAACAA CCGAGCACAT TCCAACTACC 2460 GGGCTGGCAT GATCATAGAC AACGGAGTCA AAACCACCGA GGCCTCTGCC AAGGACAAGC 2520 GGCCGTTCCT CTCAATCATC TCTGCCAGAT ACAGCCCTCA CCAGGACGCC GACCCGCTGA 2580 AGCCCCGGGA GCCGGCCATC ATCAGACACT TCATTGCCTA CAAGAACCAG GACCACGGGG 2640 CCTGGCTGCG CGGCGGGGAT GTGTGGCTGG ACAGCTGCCG GTTTGCTGAC AATGGCATTG 2700 GCCTGACCCT GGCCAGTGGT GGAACCTTCC CGTATGACGA CGGCTCCAAG CAAGAGATAA 2760 AGAACAGCTT GTTTGTTGGC GAGAGTGGCA ACGTGGGGAC GGAAATGATG GACAATAGGA 2820 TCTGGGGCCC TGGCGGCTTG GACCATAGCG GAAGGACCCT CCCTATAGGC CAGAATTTTC 2880 CAATTAGAGG AATTCAGTTA TATGATGGCC CCATCAACAT CCAAAACTGC ACTTTCCGAA 2940 AGTTTGTGGC CCTGGAGGGC CGGCACACCA GCGCCCTGGC CTTCCGCCTG AATAATGCCT 3000 GGCAGAGCTG CCCCCATAAC AACGTGACCG GCATTGCCTT TGAGGACGTT CCGATTACTT 3060 CCAGAGTGTT CTTCGGAGAG CCTGGGCCCT GGTTCAACCA GCTGGACATG GATGGGGATA 3120 AGACATCTGT GTTCCATGAC GTCGACGGCT CCGTGTCCGA GTACCCTGGC TCCTACCTCA 3180 CGAAGAATGA CAACTGGCTG GTCCGGCACC CAGACTGCAT CAATGTTCCC GACTGGAGAG 3240 GGGCCATTTG CAGTGGGTGC TATGCACAGA TGTACATTCA AGCCTACAAG ACCAGTAACC 3300 TGCGAATGAA GATCATCAAG AATGACTTCC CCAGCCACCC TCTTTACCTG GAGGGGGCGC 3360 TCACCAGGAG CACCCATTAC CAGCAATACC AACCGGTTGT CACCCTGCAG AAGGGCTACA 3420 CCATCCACTG GGACCAGACG GCCCCCGCCG AACTCGCCAT CTGGCTCATC AACTTCAACA 3480 AGGGCGACTG GATCCGAGTG GGGCTCTGCT ACCCGCGAGG CACCACATTC TCCATCCTCT 3540 CGGATGTTCA CAATCGCCTG CTGAAGCAAA CGTCCAAGAC GGGCGTCTTC GTGAGGACCT 3600 TGCAGATGGA CAAAGTGGAG CAGAGCTACC CTGGCAGGAG CCACTACTAC TGGGACGAGG 3660 ACTCAGGGCT GTTGTTCCTG AAGCTGAAAG CTCAGAACGA GAGAGAGAAG TTTGCTTTCT 3720 GCTCCATGAA AGGCTGTGAG AGGATAAAGA TTAAAGCTCT GATTCCAAAG AACGCAGGCG 3780 TCAGTGACTG CACAGCCACA GCTTACCCCA AGTTCACCGA GAGGGCTGTC GTAGACGTGC 3840 CGATGCCCAA GAAGCTCTTT GGTTCTCAGC TGAAAACAAA GGACCATTTC TTGGAGGTGA 3900 AGATGGAGAG TTCCAAGCAG CACTTCTTCC ACCTCTGGAA CGACTTCGCT TACATTGAAG 3960 TGGATGGGAA GAAGTACCCC AGTTCGGAGG ATGGCATCCA GGTGGTGGTG ATTGACGGGA 4020 ACCAAGGGCG CGTGGTGAGC CACACGAGCT TCAGGAACTC CATTCTGCAA GGCATACCAT 4080 GGCAGCTTTT CAACTATGTG GCGACCATCC CTGACAATTC CATAGTGCTT ATGGCATCAA 4140 AGGGAAGATA CGTCTCCAGA GGCCCATGGA CCAGAGTGCT GGAAAAGCTT GGGGCAGACA 4200 GGGGTCTCAA GTTGAAAGAG CAAATGGCAT TCGTTGGCTT CAAAGGCAGC TTCCGGCCCA 4260 TCTGGGTGAC ACTGGACACT GAGGATCACA AAGCCAAAAT CTTCCAAGTT GTGCCCATCC 4320 CTGTGGTGAA GAAGAAGAAG TTGTGAGGAC AGCTGCCGCC CGGTGCCACC TCGTGGTAGA 4380 CTATGACGGT GACTCTTGGC AGCAGACCAG TGGGGGATGG CTGGGTCCCC CAGCCCCTGC 4440 CAGCAGCTGC CTGGGAAGGC CGTGTTTCAG CCCTGATGGG CCAAGGGAAG GCTATCAGAG 4500 ACCCTGGTGC TGCCACCTGC CCCTACTCAA GTGTCTACCT GGAGCCCCTG GGGCGGTGCT 4560 GGCCAATGCT GGAAACATTC ACTTTCCTGC AGCCTCTTGG GTGCTTCTCT CCTATCTGTG 4620 CCTCTTCAGT GGGGGTTTGG GGACCATATC AGGAGACCTG GGTTGTGCTG ACAGCAAAGA 4680 TCCACTTTGG CAGGAGCCCT GACCCAGCTA GGAGGTAGTC TGGAGGGCTG GTCATTCACA 4740 GATCCCCATG GTCTTCAGCA GACAAGTGAG GGTGGTAAAT GTAGGAGAAA . GAGCCTTGGC 4800 CTTAAGGAAA TCTTTACTCC TGTAAGCAAG AGCCAACCTC ACAGGATTAG GAGCTGGGGT 4860 AGAACTGGCT ATCCTTGGGG AAGAGGCAAG CCCTGCCTCT GGCCGTGTCC ACCTTTCAGG 4920 AGACTTTGAG TGGCAGGTTT GGACTTGGAC TAGATGACTC TCAAAGGCCC I TTTTAGTTCT 4980 GAGATTCCAG AAATCTGCTG CATTTCACAT GGTACCTGGA ACCCAACAGT TCATGGATAT 5040 CCACTGATAT CCATGATGCT GGGTGCCCCA GCGCACACGG GATGGAGAGG I TGAGAACTAA 5100 TGCCTAGCTT GAGGGGTCTG CAGTCCAGTA GGGCAGGCAG TCAGGTCCAT GTGCACTGCA 5160
ATGCCAGGTG GAGAAATCAC AGAGAGGTAA AATGGAGGCC AGTGCCATTT CAGAGGGGAG 5220
GCTCAGGAAG GCTTCTTGCT TACAGGAATG AAGGCTGGGG GCATTTTGCT GGGGGGAGAT 5280
GAGGCAGCCT CTGGAATGGC TCAGGGATTC AGCCCTCCCT GCCGCTGCCT GCTGAAGCTG 5340
GTGACTACGG GGTCGCCCTT TGCTCACGTC TCTCTGGCCC ACTCATGATG GAGAAGTGTG 5400
GTCAGAGGGG AGCAATGGGC TTTGCTGCTT ATGAGCACAG AGGAATTCAG TCCCCAGGCA 5460
GCCCTGCCTC TGACTCCAAG AGGGTGAAGT CCACAGAAGT GAGCTCCTGC CTTAGGGCCT S520
CATTTGCTCT TCATCCAGGG AACTGAGCAC AGGGGGCCTC CAGGAGACCC TAGATGTGCT 5580
CGTACTCCCT CGGCCTGGGA TTTCAGAGCT GGAAATATAG AAAATATCTA GCCCAAAGCC 5640
TTCATTTTAA CAGATGGGGA AAGTGAGCCC CCAAGATGGG AAAGAACCAC ACAGCTAAGG 5700
GAGGGCCTGG GGAGCCCCAC CCTAGCCCTT GCTGCCACAC CACATTGCCT CAACAACCGG 5760
CCCCAGAGTG CCCAGGCACT CCTGAGGTAG CTTCTGGAAA TGGGGACAAG TCCCCTCGAA 5820
GGAAAGGAAA TGACTAGAGT AGAATGACAG CTAGCAGATC TCTTCCCTCC TGCTCCCAGC 5880
GCACACAAAC CCGCCCTCCC CTTGGTGTTG GCGGTCCCTG TGGCCTTCAC TTTGTTCACT 5940
ACCTGTCAGC CCAGCCTGGG TGCACAGTAG CTGCAACTCC CCATTGGTGC TACCTGGCTC 6000
TCCTGTCTCT GCAGCTCTAC AGGTGAGGCC CAGCAGAGGG AGTAGGGCTC GCCATGTTTC 6060
TGGTGAGCCA ATTTGGCTGA TCTTGGGTGT CTGAACAGCT ATTGGGTCCA CCCCAGTCCC 6120
TTTCAGCTGC TGCTTAATGC CCTGCTCTCT CCCTGGCCCA CCTTATAGAG AGCCCAAAGA 6180
GCTCCTGTAA GAGGGAGAAC TCTATCTGTG GTTTATAATC TTGCACGAGG CACCAGAGTC 6240
TCCCTGGGTC TTGTGATGAA CTACATTTAT CCCCTTTCCT GCCCCAACCA CAAACTCTTT 6300
CCTTCAAAGA GGGCCTGCCT GGCTCCCTCC ACCCAACTGC ACCCATGAGA CTCGGTCCAA 6360
GAGTCCATTC CCCAGGTGGG AGCCAACTGT CAGGGAGGTC TTTCCCACCA AACATCTTTC 6420
AGCTGCTGGG AGGTGACCAT AGGGCTCTGC TTTTAAAGAT ATGGCTGCTT CAAAGGCCAG 6480
AGTCACAGGA AGGACTTCTT CCAGGGAGAT TAGTGGTGAT GGAGAGGAGA GTTAAAATGA 6540
CCTCATGTCC TTCTTGTCCA CGGTTTTGTT GAGTTTTCAC TCTTCTAATG CAAGGGTCTC 6600
ACACTGTGAA CCACTTAGGA TGTGATCACT TTCAGGTGGC CAGGAATGTT GAATGTCTTT 6660
GGCTCAGTTC ATTTAAAAAA GATATCTATT TGAAAGTTCT CAGAGTTGTA CATATGTTTC 6720
ACAGTACAGG ATCTGTACAT AAAAGTTTCT TTCCTAAACC ATTCACCAAG AGCCAATATC 6780
TAGGCATTTT CTTGGTAGCA CAAATTTTCT TATTGCTTAG AAAATTGTCC TCCTTGTTAT 6840
TTCTGTTTGT AAGACTTAAG TGAGTTAGGT CTTTAAGGAA AGCAACGCTC CTCTGAAATG 6900
CTTGTCTTTT TTCTGTTGCC GAAATAGCTG GTCCTTTTTC GGGAGTTAGA TGTATAGAGT 6960
GTTTGTATGT AAACATTTCT TGTAGGCATC ACCATGAACA AAGATATATT TTCTATTTAT 7020
TTATTATATG TGCACTTCAA GAAGTCACTG TCAGAGAAAT AAAGAATTGT CTTAAATGTC 7080
Seq ID NO: 13 DNA Sequence
Nucleic Acid Accession #: NM.012112
Coding sequence: 429.-2672
1 11 21 31 41 51
I I I I I I
TCAGACCTGT AGGCCTGATA GACTGATTAA ACCACAGAAG GTGACCTGCT GAGAAAAGTG 60
GTACAAATAC TGGGAAAAAC CTGCTCTTCT GCGTTAAGTG GGAGACAATG TCACAAGTTA 120
AAAGCTCTTA TTCCTATGAT GCCCCCTCGG ATTTCATCAA TTTTTCATCC TTGGATGATG 180
AAGGAGATAC TCAAAACATA GATTCATGGT TTGAGGAGAA GGCCAATTTG GAGAATAAGT 240
TACTGGGGAA GAATGGAACT GGAGGGCTTT TTCAGGGCAA AACTCCTTTG AGAAAGGCTA 300
ATCTTCAGCA AGCTATTGTC ACACCTTTGA AACCAGTTGA CAACACTTAC TACAAAGAGG 360
CAGAAAAAGA AAATCTTGTG GAACAATCCA TTCCGTCAAA TGCTTGTTCT TCCCTGGAAG 420
TTGAGGCAGC CATATCAAGA AAAACTCCAG CCCAGCCTCA GAGAAGATCT CTTAGGCTTT 480
CTGCTCAGAA GGATTTGGAA CAGAAAGAAA AGCATCATGT AAAAATGAAA GCCAAGAGAT 540
GTGCCACTCC TGTAATCATC GATGAAATTC TACCCTCTAA GAAAATGAAA GTTTCTAACA 600
ACAAAAAGAA GCCAGAGGAA GAAGGCAGTG CTCATCAAGA TACTGCTGAA AAGAATGCAT 660
CTTCCCCAGA GAAAGCCAAG GGTAGACATA CTGTGCCTTG TATGCCACCT GCAAAGCAGA 720
AGTTTCTAAA AAGTACTGAG GAGCAAGAGC TGGAGAAGAG TATGAAAATG CAGCAAGAGG 780
TGGTGGAGAT GCGGAAAAAG AATGAAGAAT TCAAGAAACT TGCTCTGGCT GGAATAGGGC 840
AACCTGTGAA GAAATCAGTG AGCCAGGTCA CCAAATCAGT TGACTTCCAC TTCCGCACAG 900
ATGAGCGAAT CAAACAACAT CCTGAGAACC AGGAGGAATA TAAGGAAGTG AACTTTACAT 960
CTGAACTACG AAAGCATCCT TCATCTCCTG CCCGAGTGAC TAAGGGATGT ACCATTGTTA 1020
AGCCTTTCAA CCTGTCCCAA GGAAAGAAAA GAACATTTGA TGAAACAGTT TCTACATATG 1080
TGCCCCTTGC ACAGCAAGTT GAAGACTTCC ATAAACGAAC CCCTAACAGA TATCATTTGA 1140
GGAGCAAGAA GGATGATATT AACCTGTTAC CCTCCAAATC TTCTGTGACC AAGATTTGCA 1200
GAGACCCACA GACTCCTGTA CTGCAAACCA AACACCGTGC ACGGGCTGTG ACCTGCAAAA 1260
GTACAGCAGA GCTGGAGGCT GAGGAGCTCG AGAAATTGCA ACAATACAAA TTCAAAGCAC 1320
GTGAACTTGA TCCCAGAATA CTTGAAGGTG GGCCCATCTT GCCCAAGAAA CCACCTGTGA 1380
AACCACCCAC CGAGCCTATT GGCTTTGATT TGGAAATTGA GAAAAGAATC CAGGAGCGAG 1440
AATCAAAGAA GAAAACAGAG GATGAACACT TTGAATTTCA TTCCAGACCT TGCCCTACTA 1500
AGATTTTGGA AGATGTTGTG GGTGTTCCTG AAAAGAAGGT ACTTCCAATC ACCGTCCCCA 1560
AGTCACCAGC CTTTGCATTG AAGAACAGAA TTCGAATGCC CACCAAAGAA GATGAGGAAG 1620
AGGACGAACC GGTAGTGATA AAAGCTCAAC CTGTGCCACA TTATGGGGTG CCTTTTAAGC 1680
CCCAAATCCC AGAGGCAAGA ACTGTGGAAA TATGCCCTTT CTCCTTTGAT TCTCGAGACA 1740
AAGAACGTCA GTTACAGAAG GAGAAGAAAA TAAAAGAACT GCAGAAAGGG GAGGTGCCCA 1800
AGTTCAAGGC ACTTCCCTTG CCTCATTTTG ACACCATTAA CCTGCCAGAG AAGAAGGTAA 1860
AGAATGTGAC CCAGATTGAA CCTTTCTGCT TGGAGACTGA CAGAAGAGGT GCTCTGAAGG 1920
CACAGACTTG GAAGCACCAG CTGGAAGAAG AACTGAGACA GCAGAAAGAA GCAGCTTGTT 1980
TCAAGGCTCG TCCAAACACC GTCATCTCTC AGGAGCCCTT TGTTCCCAAG AAAGAGAAGA 2040
AATCAGTTGC TGAGGGCCTT TCTGGTTCTC TAGTTCAGGA ACCTTTTCAG CTGGCTACTG 2100
AGAAGAGAGC CAAAGAGCGG CAGGAGCTGG AGAAGAGAAT GGCTGAGGTA GAAGCCCAGA 2160
AAGCCCAGCA GTTGGAGGAG GCCAGACTAC AGGAGGAAGA GCAGAAAAAA GAGGAGCTGG 2220
CCAGGCTACG GAGAGAACTG GTGCATAAGG CAAATCCAAT ACGCAAGTAC CAGGGTCTGG 2280
AGATAAAGTC AAGTGACCAG CCTCTGACTG TGCCTGTATC TCCCAAATTC TCCACTCGAT 2340
TCCACTGCTA AACTCAGCTG TGAGCTGCGG ATACCGCCCG GCAATGGGAC CTGCTCTTAA 2400
CCTCAAACCT AGGACCGTCT TGCTTTGTCA TTGGGCATGG AGAGAACCCA TTTCTCCAGA 2460
CTTTTACCTA CCCGTGCCTG AGAAAGCATA CTTGACAACT GTGGACTCCA GTTTTGTTGA 2520
GAATTGTTTT CTTACATTAC TAAGGCTAAT AATGAGATGT AACTCATGAA TGTCTCGATT 2580
AGACTCCATG TAGTTACTTC CTTTAAACCA TCAGCCGGCC TTTTATATGG GTCTTCACTC 2640
TGACTAGAAT TTAGTCTCTG TGTCAGCACA GTGTAATCTC TATTGCTATT GCCCCTTACG 2700 ACTCTCACCC TCTCCCCAAC TTTTTTTAAA AATTTTAACC AGAAAATAAA GATAGTTAAA 2760
TCCTAAGATA GAGATTAAGT CATGGTTTAA ATGAGGAACA ATCAGTAAAT CAGATTCTGT 2820
CCTCTTCTCT GCATACCGTG AATTTATAGT TAAGGATCCC TTTGCTGTGA GGGTAGAAAA 2880
CCTCACCAAC TGCACCAGTG AGGAAGAAGA CTGCGTGGAT TCATGGGGAG CCTCACAGCA 2940 GCCACGCAGC AGGCTCTGGG TGGGGCTGCC GTTAAGGCAC GTTCTTTCCT TACTGGTGCT 3000
GATAACAACA GGGAACCGTG CAGTGTGCAT TTTAAGACCT GGCCTGGAAT AAATACGTTT 3060
TGTCTTTCCC TC 3072
Seq ID NO 14 DNA Sequence Nucleic Acid Accession It Eos sequence
1 11 21 31 41 51
ATTTCTTGAG ATGGCTCCTC TTGGAACTAT GCATCTCTCC TGATACTTGG ATGCTTTTCC 60
TCTGACTGAT GAAGATCCTG AATACCAAAG AGGGCCGCTG AAAGGGCTCT AGGAGTACAC 120
CTTCTAGGAA CCCTAAGCCA GAGAGAGGCT TCACTACATC ATGCTTCCTG ACATCTCTCC 180
CTTTGAAGAG CAGTCAGACT CCTGCTTTGC TCTTCAGACT TAATTTGGGG GTTTAACAGG 240
TGAGGTTGCT GGGGGAACTC TTTTACAACA TCTCTCTGAA AGAATCCGGG CTGCCAGTTT 300
CATTTGGTTT GGGTGTCAGT AGCATGATGG AAAGACAAAA AAACACAACT TGACATCTGC 360
AGAAATGGGT TCAAATTTTA CCTGCAACTC ACCAATTCTG TGGCCTTGGT TCAGCAATTA 420
AACTCCCTAA AATTCAGTTT TTTCTTTGTA AAATGGGGTT ATGAACAGTA CCTACTTCAA 480
AATGTGTTTG TGAAGATTAA AAAAGTTAAC ATAAAGAGTT TAGAAGAGTG TCTGGCATAT 540
TGTGCTCAAT AAGTGTTTAT TTATTTATTG CTGAATAAAC CAGTAATTTA ATTAGTAT 598
Seq ID NO 15 DNA Sequence
Nucleic Acid Accession # Eos sequence
Coding sequence 63 3224
1 11 21 31 41 SI
I I I I I I
CAGGAATTTG TGGCGGAGAG GGCAAATAAC TGCGGCTCTC CCGGCGCCCC GATGCTCGCA 60
CCATGTCGAG GCGCAAGCAG GCGAAACCCC AGCACATCAA CTCGGAGGAG GACCAGGGCG 120
AGCAGCAGCC GCAGCAGCAG ACCCCGGAGT TTGCAGATGC GGCCCCAGCG GCGCCCGCGG 180
CGGGGGAGCT GGGTGCTCCA GTGAACCACC CAGGGAATGA CGAGGTGGCG AGTGAGGATG 240
AAGCCACAGT AAAGCGGCTT CGTCGGGAGG AGACGCACGT CTGTGAGAAA TGCTGTGCGG 300
AGTTCTTCAG CATCTCTGAG TTCCTGGAAC ATAAGAAAAA TTGCACTAAA AATCCACCTG 360
TCCTCATCAT GAATGACAGC GAGGGGCCTG TGCCTTCAGA AGACTTCTCC GGAGCTGTAC 420
TGAGCCACCA GCCCACCAGT CCCGGCAGTA AGGACTGTCA CAGGGAGAAT GGCGGCAGCT 480
CAGAGGACAT GAAGGAGAAG CCGGATGCGG AGTCTGTGGT GTACCTAAAG ACAGAGACAG 540
CCCTGCCACC CACCCCCCAG GACATAAGCT ATTTAGCCAA AGGCAAAGTG GCCAACACTA 600
ATGTGACCTT GCAGGCACTA CGGGGCACCA AGGTGGCGGT GAATCAGCGG AGCGCGGATG 660
CACTCCCTGC CCCCGTGCCT GGTGCCAACA GCATCCCGTG GGTCCTCGAG CAGATCTTGT 720
GTCTGCAGCA GCAGCAGCTA CAGCAGATCC AGCTCACCGA GCAGATCCGC ATCCAGGTGA 780
ACATGTGGGC CTCCCACGCC CTCCACTCAA GCGGGGCAGG GGCCGACACT CTGAAGACCT 840
TGGGCAGCCA CATGTCTCAG CAGGTTTCTG CAGCTGTGGC TTTGCTCAGC CAGAAAGCTG 900
GAAGCCAAGG TCTGTCTCTG GATGCCTTGA AACAAGCCAA GCTACCTCAC GCCAACATCC 960
CTTCTGCCAC CAGCTCCCTG TCCCCAGGGC TGGCACCCTT CACTCTGAAG CCGGATGGGA 1020
CCCGGGTGCT CCCGAACGTC ATGTCCCGCC TCCCGAGCGC TTTGCTTCCT CAGGCCCCGG 1080
GCTCGGTGCT CTTCCAGAGC CCTTTCTCCA CTGTGGCGCT AGACACATCC AAGAAAGGGA 1140
AGGGGAAGCC ACCGAACATC TCCGCGGTGG ATGTCAAACC CAAAGACGAG GCGGCCCTCT 1200
ACAAGCACAA GTGTAAGTAC TGTAGCAAGG TTTTTGGGAC TGATAGCTCC TTGCAGATCC 1260
ACCTCCGCTC CCACACTGGA GAGAGACCCT TCGTGTGCTC TGTCTGTGGT CATCGCTTCA 1320
CCACCAAGGG CAACCTCAAG GTGCACTTTC ACCGACATCC CCAGGTGAAG GCAAACCCCC 1380
AGCTGTTTGC CGAGTTCCAG GACAAAGTGG CGGCCGGCAA TGGCATCCCC TATGCACTCT 1440
CTGTACCTGA CCCCATAGAT GAACCGAGTC TTTCTTTAGA CAGCAAACCT GTCCTTGTAA 1500
CCACCTCTGT AGGGCTACCT CAGAATCTTT CTTCGGGGAC TAATCCCAAG GACCTCACGG 1S60
GTGGCTCCTT GCCCGGTGAC CTGCAGCCTG GGCCTTCTCC AGAAAGTGAG GGTGGACCCA 1620
CACTCCCTGG GGTGGGACCA AACTATAATT CCCCAAGGGC TGGTGGCTTC CAAGGGAGTG 1680
GGACCCCTGA GCCAGGGTCA GAGACCCTGA AATTGCAGCA GTTGGTGGAG AACATTGACA 1740
AGGCCACCAC TGATCCCAAC GAATGTCTCA TTTGCCACCG AGTCTTAAGC TGTCAGAGCT 1800
CCCTCAAGAT GCATTATCGC ACCCACACCG GGGAGAGACC GTTCCAGTGT AAGATCTGTG 1860
GCCGAGCCTT TTCTACCAAA GGTAACCTGA AGACACACCT TGGGGTTCAC CGAACCAACA 1920
CATCCATTAA GACGCAGCAT TCGTGCCCCA TCTGCCAGAA GAAGTTCACT AATGCCGTGA 1980
TGCTGCAGCA ACATATTCGG ATGCACATGG GCGGTCAGAT TCCCAACACG CCCCTGCCAG 2040
AGAATCCCTG TGACTTTACG GGTTCTGAGC CAATGACCGT GGGTGAGAAC GGCAGCACCG 2100
GCGCTATCTG CCATGATGAT GTCATCGAAA GCATCGATGT AGAGGAAGTC AGCTCCCAGG 2160
AGGCTCCCAG CAGCTCCTCC AAGGTCCCCA CGCCTCTTCC CAGCATCCAC TCGGCATCAC 2220
CCACGCTAGG GTTTGCCATG ATGGCTTCCT TAGATGCCCC AGGGAAAGTG GGTCCTGCCC 2280
CTTTTAACCT GCAGCGCCAG GGCAGCAGAG AAAACGGTTC CGTGGAGAGC GATGGCTTGA 2340
CCAACGACTC ATCCTCGCTG ATGGGAGACC AGGAGTATCA GAGCCGAAGC CCAGATATCC 2400
TGGAAACCAC ATCCTTCCAG GCACTCTCCC CGGCCAATAG TCAAGCCGAA AGCATCAAGT 2460
CAAAGTCTCC CGATGCTGGG AGCAAAGCAG AGAGCTCCGA GAACAGCCGC ACTGAGATGG 2520
AAGGTCGGAG CAGTCTCCCT TCCACGTTTA TCCGAGCCCC GCCGACCTAT GTCAAGGTTG 2580 AAGTTCCTGG CACATTTGTG GGACCCTCGA CATTGTCCCC AGGGATGACC CCTTTGTTAG 2640
CAGCCCAGCC ACGCCGACAG GCCAAGCAAC ATGGCTGCAC ACGGTGTGGG AAGAACTTCT 2700
CGTCTGCTAG CGCTCTTCAG ATCCACGAGC GGACTCACAC TGGAGAGAAG CCTTTTGTGT 2760 GCAACATTTG TGGGCGAGCT TTTACCACCA AAGGCAACTT AAAGGTTCAC TACATGACAC 2820 ACGGGGCGAA CAATAACTCA GCCCGCCGTG GAAGGAAGTT GGCCATCGAG AACACCATGG 2880 CTCTGTTAGG TACGGACGGA AAAAGAGTCT CAGAAATCTT TCCCAAGGAA ATCCTGGCCC 2940 CTTCAGTGAA TGTGGACCCT GTTGTGTGGA ACCAGTACAC CAGCATGCTC AATGGCGGTC 3000 TGGCCGTGAA GACCAATGAG ATCTCTGTGA TCCAGAGTGG GGGGGTTCCT ACCCTCCCGG 3060 TTTCCTTGGG GGCCACCTCC GTTGTGAATA ACGCCACTGT CTCCAAGATG GATGGCTCCC 3120 AGTCGGGTAT CAGTGCAGAT GTGGAAAAAC CAAGTGCTAC TGACGGCGTT CCCAAACACC 3180 AGTTTCCTCA CTTCCTGGAA GAAAACAAGA TTGCGGTCAG CTAAGGGAGA ACTTGCGTGG 3240 AAGGAGCAAT GCAGACACAG TGAAATCTCT AGAATCTGCT TTGTTTTGTA AGAACTCATC 3300 TCCTCCTGTT TTCTTTTTCT TACTGATATG CAAATGATGT TTACTACGTT GGTTGTGACC 3360 ACAACCTCAG GCAAGTGCTA CAATCACGAT TGTTGCTATG CTGCTTTGCA AAAAGTTG 3 18
Seq ID NO 16 DNA Sequence
Nucleic Acid Accession tl NM_005101
Coding sequence 76 573
1 11 21 31 41 51
I I I I I I
CGGCTGAGAG GCAGCGAACT CATCTTTGCC AGTACAGGAG CTTGTGCCGT GGCCCACAGC 60
CCACAGCCCA CAGCCATGGG CTGGGACCTG ACGGTGAAGA TGCTGGCGGG CAACGAATTC 120
CAGGTGTCCC TGAGCAGCTC CATGTCGGTG TCAGAGCTGA AGGCGCAGAT CACCCAGAAG 180
ATTGGCGTGC ACGCCTTCCA GCAGCGTCTG GCTGTCCACC CGAGCGGTGT GGCGCTGCAG 240
GACAGGGTCC CCCTTGCCAG CCAGGGCCTG GGCCCTGGCA GCACGGTCCT GCTGGTGGTG 300
GACAAATGCG ACGAACCTCT GAGCATCCTG GTGAGGAATA ACAAGGGCCG CAGCAGCACC 360
TACGAGGTCC GGCTGACGCA GACCGTGGCC CACCTGAAGC AGCAAGTGAG CGGGCTGGAG 420
GGTGTGCAGG ACGACCTGTT CTGGCTGACC TTCGAGGGGA AGCCCCTGGA GGACCAGCTC 480
CCGCTGGGGG AGTACGGCCT CAAGCCCCTG AGCACCGTGT TCATGAATCT GCGCCTGCGG 540
GGAGGCGGCA CAGAGCCTGG CGGGCGGAGC TAAGGGCCTC CACCAGCATC CGAGCAGGAT 600
CAAGGGCCGG AAATAAAGGC TGTTGTAAGA GAAT 634
Seq ID NO 17 DNA sequence
Nucleic Acid Accession # Eos sequence
Coding sequence 62 895
1 11 21 31 41 51
I I I I I I
CACTGCTCTG AGAATTTGTG AGCAGCCCCT AACAGGCTGT TACTTCACTA CAACTGACGA 60
TATGATCATC TTAATTTACT TATTTCTCTT GCTATGGGAA GACACTCAAG GATGGGGATT 120
CAAGGATGGA ATTTTTCATA ACTCCATATG GCTTGAACGA GCAGCCGGTG TGTACCACAG 180
AGAAGCACGG TCTGGCAAAT ACAAGCTCAC CTACGCAGAA GCTAAGGCGG TGTGTGAATT 240
TGAAGGCGGC CATCTCGCAA CTTACAAGCA GCTAGAGGCA GCCAGAAAAA TTGGATTTCA 300
TGTCTGTGCT GCTGGATGGA TGGCTAAGGG CAGAGTTGGA TACCCCATTG TGAAGCCAGG 360
GCCCAACTGT GGATTTGGAA AAACTGGCAT TATTGATTAT GGAATCCGTC TCAATAGGAG 420
TGAAAGATGG GATGCCTATT GCTACAACCC ACACGCAAAG GAGTGTGGTG GCGTCTTTAC 480
AGATCCAAAG CAAATTTTTA AATCTCCAGG CTTCCCAAAT GAGTACGAAG ATAACCAAAT 540
CTGCTACTGG CACATTAGAC TCAAGTATGG TCAGCGTATT CACCTGAGTT TTTTAGATTT 600
TGACCTTGAA GATGACCCAG GTTGCTTGGC TGATTATGTT GAAATATATG ACAGTTACGA 660
TGATGTCCAT GGCTTTGTGG GAAGATACTG TGGAGATGAG CTTCCAGATG ACATCATCAG 720
TACAGGAAAT GTCATGACCT TGAAGTTTCT AAGTGATGCT TCAGTGACAG CTGGAGGTTT 780
CCAAATCAAA TATGTTGCAA TGGATCCTGT ATCCAAATCC AGTCAAGGAA AAAATACAAG 840
TACTACTTCT ACTGGAAATA AAAACTTTTT AGCTGGAAGA TTTAGCCACT TATAAAAAAA 900
AAAAAAAGGA TGATCAAAAC ACACAGTGTT TATGTTGGAA TCTTTTGGAA CTCCTTTGAT 960
CTCACTGTTA TTATTAACAT TTATTTATTA TTTTTCTAAA TGTGAAAGCA ATACATAATT 1020
TAGGGAAAAT TGGAAAATAT AGGAAACTTT AAACGAGAAA ATGAAACCTC TCATAATCCC 1080
ACTGCATAGA AATAACAAGC GTTAACATTT TCATATTTTT TTCTTTCAGT CATTTTTCTA 1140
TTTGTGGTAT ATGTATA AT GTACCTATAT GTATTTGCAT TTGAAATTTT GGAATCCTGC 1200
TC ATGTACA GTTTTGTATT ATACTTTTTA AATCTTGAAC TTTATAAACA TTTTCTGAAA 1260
TCATTGATTA TTCTACAAAA ACATGATTTT AAACAGCTGT AAAATATTCT ATGATATGAA 1320
TGTTTTATGC ATTATTTAAG CCTGTCTCTA TTGTTGGAAT TTCAGGTCAT TTTCATAAAT 1380 ATTGTTGCAA TAAATATCCT TGAACACACA AAAAAAAAAA AA
Seq ID NO 18 DNA sequence
Nucleic Acid Accession H NM.007115 1
Coding sequence 69 902
1 11 21 31 41 51
I I I I I I
GAATTCGCAC TGCTCTGAGA ATTTGTGAGC AGCCCCTAAC AGGCTGTTAC TTCACTACAA 60
CTGACGATAT GATCATCTTA ATTTACTTAT TTCTCTTGCT ATGGGAAGAC ACTCAAGGAT 120
GGGGATTCAA GGATGGAATT TTTCATAACT CCATATGGCT TGAACGAGCA GCCGGTGTGT 180
ACCACAGAGA AGCACGGTCT GGCAAATACA AGCTCACCTA CGCAGAAGCT AAGGCGGTGT 240
GTGAATTTGA AGGCGGCCAT CTCGCAACTT ACAAGCAGCT AGAGGCAGCC AGAAAAATTG 300
GATTTCATGT CTGTGCTGCT GGATGGATGG CTAAGGGCAG AGTTGGATAC CCCATTGTGA 360
AGCCAGGGCC CAACTGATGA TTTGGAAAAA CTGGCATTAT TGATTATGGA ATCCGTCTCA 420
ATAGGAGTGA AAGATGGGAT GCCTATTGCT ACAACCCACA CGCAAAGGAG TGTGGTGGCG 480
TCTTTACAGA TCCAAAGCGA ATTTTTAAAT CTCCAGGCTT CCCAAATGAG TACGAAGATA 540
ACCAAATCTG CTACTGGCAC ATTAGACTCA AGTATGGTCA GCGTATTCAC CTGAGTTTTT 600
TAGATTTTGA CCTTGAAGAT GACCCAGGTT GCTTGGCTGA TTATGTTGAA ATAT TGACA 660
GTTACGATGA TGTCCATGGC TTTGTGGGAA GATACTGTGG AGATGAGCTT CCAGATGACA 720
TCATCAGTAC AGGAAATGTC ATGACCTTGA AGTTTCTAAG TGATGCTTCA GTGACAGCTG 780
GAGGTTTCCA AATCAAATAT GTTGCAATGG ATCCTGTATC CAAATCCAGT CAAGGAAAAA 840
ATACAAGTAC TACTTCTACT GGAAATAAAA ACTTTTTAGC TGGAAGATTT AGCCACTTAT 900
AAAAAAAAAA AAGGATGATC AAAACACACA GTGTTTATGT TGGAATCTTT TGGAACTCCT 960
TTGATCTCAC TGTTATTATT AACATTTATT TATTATTTTT CTAAATGTGA AAGAAATACA 1020
TAATTTAGGG AAAATTGGAA AATATAGGAA ACTTTAAACG AGAAAATGAA ACCTCTCATA 1080
ATCCCACTGC ATAGAAATAA CAAGCGTTAA CATTTTCATA TTTTTTTCTT TCAGTCATTT 1140
TTGTATTTGT GGTATATGTA TATATGTACC TATATGTATT TGCATTTGAA ATTTTGGAAT 1200
CCTGCTCTAT GTACAGTTTT GTATTATACT TTTTAAATCT TGAACTTTAT GAACATTTTC 1260
TGAAATCATT GATTATTCTA CAAAAACATG ATTTTAAACA GCTGTAAAAT ATTCTATGAT 1320
ATGAATGTTT TATGCATTAT TTAAGCCTGT CTCTATTGTT GGAATTTCAG GTCATTTTCA 1380 TAAATATTGT TGCAATAAAT ATCCTTCGGA ATTC Seq ID NO 19 DNA Sequence
Nucleic Acid Accession tt NM.006398 1
Coding sequence 19 516
1 11 21 31 41 51
I I I I I I GGCCCCTTGT CTGCAGAGAT GGCTCCCAAT GCTTCCTGCC TCTGTGTGCA TGTCCGTTCC 60
GAGGAATGGG ATTTAATGAC CTTTGATGCC AACCCAT TG ACAGCGTGAA AAAAATCAAA 120
GAACATGTCC GGTCTAAGAC CAAGGTTCCT GTGCAGGACC AGGTTCTTTT GCTGGGCTCC 180
AAGATCTTAA AGCCACGGAG AAGCCTCTCA TCTTATGGCA TTGACAAAGA GAAGACCATC 240 CACCTTACCC TGAAAGTGGT GAAGCCCAGT GATGAGGAGC TGCCCTTGTT TCTTGTGGAG 300
TCAGGTGATG AGGCAAAGAG GCACCTCCTC CAGGTGCGAA GGTCCAGCTC AGTGGCACAA 360
GTGAAAGCAA TGATCGAGAC TAAGACGGGT ATAATCCCTG AGACCCAGAT TGTGACTTGC 420
AATGGAAAGA GACTGGAAGA TGGGAAGATG ATGGCAGATT ACGGCATCAG AAAGGGCAAC 80
TTACTCTTCC TGGCATCTTA TTGTATTGGA GGGTGACCAC CCTGGGGATG GGGTGTTGGC 540 AGGGGTCAAA AAGCTTATTT CTTTTAATCT CTTACTCAAC GAACACATCT TCTGATGATT 600
TCCCAAAATT AATGAGAATG AGATGAGTAG AGTAAGATTT GGGTGGGATG GGTAGGATGA 660
AGTATATTGC CCAACTCTAT GTTTCTTTGA TTCTAACACA ATTAATTAAG TGACATGATT 720
TTTACTAATG TATTACTGAG ACTAGTAAAT AAATTTTTAA GGCAAAATAG AGCATTC 777
Seq ID NO 20 DNA Sequence
Nucleic Acid Accession If NM_002358 2
Coding sequence 75 692
1 11 21 31 41 51
I I I I I I
GGGAAGTGCT GTTGGAGCCG CTGTGGTTGC TGTCCGCGGA GTGGAAGCGC GTGCTTTTGT 60
TTGTGTCCCT GGCCATGGCG CTGCAGCTCT CCCGGGAGCA GGGAATCACC CTGCGCGGGA 120
GCGCCGAAAT CGTGGCCGAG TTCTTCTCAT TCGGCATCAA CAGCATTTTA TATCAGCGTG 180
GCATATATCC ATCTGAAACC TTTACTCGAG TGCAGAAATA CGGACTCACC TTGCTTGTAA 240
CTACTGATCT TGAGCTCATA AAATACCTAA ATAATGTGGT GGAACAACTG AAAGATTGGT 300
TATACAAGTG TTCAGTTCAG AAACTGGTTG TAGTTATCTC AAATATTGAA AGTGGTGAGG 360
TCCTGGAAAG ATGGCAGTTT GATATTGAGT GTGACAAGAC TGCAAAAGAT GACAGTGCAC 420
CCAGAGAAAA GTCTCAGAAA GCTATCCAGG ATGAAATCCG TTCAGTGATC AGACAGATCA 480
CAGCTACGGT GACATTTCTG CCACTGTTGG AAGTTTCTTG TTCATTTGAT CTGCTGATTT 540
ATACAGACAA AGATTTGGTT GTACCTGAAA AATGGGAAGA GTCGGGACCA CAGTTTATTA 600
CCAATTCTGA GGAAGTCCGC CTTCGTTCAT TTACTACTAC AATCCACAAA GTAAATAGCA 660
TGGTGGCCTA CAAAATTCCT GTCAATGACT GAGGATGACA TGAGGAAAAT AATGTAATTG 720
TAATTTTGAA ATGTGGTTTT CCTGAAATCA GGTCATCTAT AGTTGATATG TTTTATTTCA 780
TTGGTTAATT TTTACATGGA GAAAACCAAA ATGATACTTA CTGAACTGTG TGTAATTGTT 840
CCTTTATTTT TTTGGTACCT ATTTGACTTA CCATGGAGTT AACATCATGA ATTTATTGCA 900
CATTGTTCAA AAGGAACCAG GAGGTTTTTT TGTCAACATT GTGATGTATA TTCCTTTGAA 960
GATAGTAACT GTAGATGGAA AAACTTGTGC TATAAAGCTA GATGCTTTCC TAAATCAGAT 1020
GTTTTGGTCA AGTAGTTTGA CTCAGTATAG GTAGGGAGAT ATTTAAGTAT AAAATACAAC 1080
AAAGGAAGTC TAAATATTCA GAATCTTTGT TAAGGTCCTG AAAGTAACTC ATAATCTATA 1140
AACAATGAAA TATTGCTGTA TAGCTCCTTT TGACCTTCAT TTCATGTATA GTTTTCCCTA 1200
TTGAATCAGT TTCCAATTAT TTGACTTTAA TTTATGTAAC TTGAACCTAT GAAGCAATGG 1260
ATATTTGTAC TGTTTAATGT TCTGTGATAC AGAACTCTTA AAAATGTTTT TTCATGTGTT 1320
TTATAAAATC AAGTTTTAAG TGAAAGTGAG GAAATAAAGT TAAGTTTGTT TTAAAAAAAA 1380 AAAAAAAAAA 1390
Seq ID NO 21 DNA sequence
Nucleic Acid Accession # NM_001898 1
Coding sequence 57 482
1 11 21 31 41 51
I I I I I I
GGCTCTCACC CTCCTCTCCT GCAGCTCCAG CTTTGTGCTC TGCCTCTGAG GAGACCATGG 60
CCCAGTATCT GAGTACCCTG CTGCTCCTGC TGGCCACCCT AGCTGTGGCC CTGGCCTGGA 120
GCCCCAAGGA GGAGGATAGG ATAATCCCGG GTGGCATCTA TAACGCAGAC CTCAATGATG 180
AGTGGGTACA GCGTGCCCTT CACTTCGCCA TCAGCGAGTA TAACAAGGCC ACCAAAGATG 240
ACTACTACAG ACGTCCGCTG CGGGTACTAA GAGCCAGGCA ACAGACCGTT GGGGGGGTGA 300
ATTACTTCTT CGACGTAGAG GTGGGCCGCA CCATATGTAC CAAGTCCCAG CCCAACTTGG 360
ACACCTGTGC CTTCCATGAA CAGCCAGAAC TGCAGAAGAA ACAGTTGTGC TCTTTCGAGA 420
TCTACGAAGT TCCCTGGGAG AACAGAAGGT CCCTGGTGAA ATCCAGGTGT CAAGAATCCT 480
AGGGATCTGT GCCAGGCCAT TCGCACCAGC CACCACCCAC TCCCACCCCC TGTAGTGCTC 540
CCACCCCTGG ACTGGTGGCC CCCACCCTGC GGGAGGCCTC CCCATGTGCC TGCGCCAAGA 600
GACAGACAGA GAAGGCTGCA GGAGTCCTTT GTTGCTCAGC AGGGCGCTCT GCCCTCCCTC 660
CTTCCTTCTT GCTTCTAATA GCCCTGGTAC ATGGTACACA CCCCCCCACC TCCTGCAATT 720 AAACAGTAGC ATCGCC
Seq ID NO 22 DNA sequence
Nucleic Acid Accession tl NM.007231 1
Coding sequence 89 2017
1 11 21 31 41 51
I I I I I I
TAGGAACAGG GGAGAGTGCA CCTGCTACCA GTCAAGCTCA GCCAGACTGC AAGAGGAGGC 60
GAGGCGGAGC CAGCCGAGGG AGTGAACCAT GGACAAGTTG AAATGCCCGA GTTTCTTCAA 120
GTGCAGGGAG AAGGAGAAAG TGTCGGCTTC ATCAGAGAAT TTCCATGTTG GTGAAAATGA 180
TGAGAATCAG GACCGTGGTA ACTGGTCCAA AAAATCGGAT TATCTTCTAT CTATGATTGG 240
ATACGCAGTG GGATTAGGAA ATGTGTGGAG ATTTCCATAT CTGACCTACA GCAATGGTGG 300
AGGCGCCTTC TTGATACCTT ATGCAATTAT GTTAGCATTG GCTGGTTTAC CTTTGTTCTT 360
TCTGGAGTGT TCACTGGGAC AATTTGCTAG CTTAGGTCCA GTTTCAGTTT GGAGGATTCT 420
TCCATTGTTT CAAGGTGTGG GAATTACAAT GGTCCTGATC TCCATTTTTG TGACAATCTA 480
TTACAATGTC ATAATTGCCT ATAGTCTTTA CTACATGTTT GCTTCTTTTC AAAGTGAACT 540
ACCATGGAAA AATTGTTCTT CGTGGTCAGA TAAAAACTGT AGCAGATCAC CAATAGTAAC 600 TCACTGTAAT GTGAGTACAG TGAATAAAGG AATACAAGAG ATCATCCAAA TGAATAAAAG 660 CTGGGTAGAC ATCAACAATT TTACCTGCAT CAACGGCAGT GAAATTTATC AGCCAGGGCA 720
GCTTCCCAGT GAACAA ATT GGAATAAAGT GGCGCTCCAA CGGTCAAGTG GAATGAATGA 780
GACTGGAGTA ATTGTTTGGT ATTTAGCACT TTGTCTTCTT CTGGCTTGGC TCATAGTTGG 840
AGCAGCACTA TTTAAAGGAA TCAAATCGTC TGGCAAGGTG GTATATTTTA CAGCTCTTTT 900
CCCCTATGTG GTCCTACTCA TCCTGTTAGT ACGAGGTGCA ACTCTGGAGG GTGCTTCAAA 960 AGGCATTTCA TACTATATTG GAGCCCAGTC AAATTTTACA AAACTTAAGG AAGCTGAGGT 1020
ATGGAAAGAT GCTGCCACTC AGATATTTTA CTCCCTTTCA GTGGCTTGGG GTGGCTTAGT 1080
TGCTCTATCA TCTTACAATA AGTTCAAAAA CAACTGCTTC TCTGATGCCA TTGTGGTTTG 1140
TTTGACAAAC TGTCTCACTA GCGTGTTTGC TGGATTTGCT ATTTTTTCTA TATTGGGACA 1200
CATGGCCCAT ATATCTGGAA AGGAAGTTTC TCAAGTTGTA AAATCAGGTT TTGATTTGGC 1260
ATTCATTGCC TATCCAGAGG CTCTAGCCCA ACTCCCAGGT GGTCCATTTT GGTCCATATT 1320
ATTTTTTTTC ATGCTTTTAA CTTTGGGTCT CGATTCTCAG TTTGCTTCGA TTGAAACGAT 1380
CACAACAACA ATTCAAGATT TATTTCCCAA AGTGATGAAG AAAATGAGGG TTCCCATAAC 1440
TTTGGGCTGC TGCTTGGTTT TGTTTCTCCT TGGTCTCGTC TGTGTGACTC AGGCTGGAAT 1500
TTACTGGGTT CATCTGATTG ACCACTTCTG TGCTGGATGG GGCATTTTAA TTGCAGCTAT 1560
ACTGGAGCTA GTTGGAATCA TCTGGATTTA TGGAGGGAAC AGATTCATTG AGGATACAGA 1620
AATGATGATT GGAGCAAAGA GGTGGATATT CTGGCTATGG TGGAGAGCTT GCTGGTTTGT 1680
AATTACGCCT ATCCTTTTGA TTGCAATATT TATCTGGTCA TTGGTGCAAT TTCATAGACC 1740
TAATTATGGC GCAATTCCAT ACCCTGACTG GGGAGTTGCT TTAGGCTGGT GTATGATTGT 1800 TTTCTGCATT ATTTGGATAC CAATTATGGC TATCATAAAA ATAATTCAGG CTAAAGGAAA 1860
CATCTTTCAA CGCCTTATAA GTTGCTGCAG ACCAGCTTCT AACTGGGGTC CATACCTGGA 1920
ACAACATCGT GGGGAAAGAT ATAAAGACAT GGTAGATCCT AAAAAAGAGG CTGACCATGA 1980
AATACCTACT GTTAGTGGCA GCAGAAAACC GGAATGAGAT CTCATTGAAA AAAATATATG 2040
ATTGTATAAT GTGATTTTTT TTAGAATAGG GGGAACCTTA TTTATTTGTG TGTTAACTGA 2100
ATAGGAAAAT GTACATACTA TGTTCATGAT AGTGTGATTT TTTTCACATT TAAGCAGGAA 2160
TGCAATATAA AAATGTGAAT CTCTTAATTC TCAGCCATGT GCTTATTATA TTTCTTTTTA 2220
GATTGTCTAT CTGTATAACA CACACACACA CACCTAAGAG TCTCTATTTC ACAATTATAT 2280
TTTTGTAAAT AGTATATGCA TTTTTAATAC ATTGGAGGCT TTATTTTGAA CTAATTTCTT 2340
AGAGAATAGT TATATTTTCT ATTACACAAG TTTAAAAATA TTATTAACTT GTATTTTCTT 2400
AATATACAAT CTATCTTTTC CACAAATATG AGTGGGAAAT AAATCAGCAC ATTTGAAAGA 2460
AAGTGTTAAA ACTGAAGGCC TCACTTAATT AGAAACGTGA TAAATATATG GACAAATGGA 2520
CTATACATAC TATAAGAGGA CTGTAGTTTA ATACTTTTTA CCCAAATATG TTTAAAAACA 2580
TCGTGCATTT GTTACAGCTC ATGTTTTCTA TATGAACTTA GTCATTAATG TTCTTTATAA 2640
AAAGTGAAAT AAGATGGAAA AATTAGGATC CTACAGCCAG TACGTGATAA ATCTAGAAAA 2700
TTGAGTTTTG AGTACCTCTT TTCCCATATA CAATCTTCCT TCCTTAGGTA ATTTGGAAGA 2760
AAACTATGAC CCATTTAATT TCTATTGTGT TTCACCAAAT TCAGTGTTGT TCATTATACC 2820
TCTCTGAAAT ATAGGTTTAA TTTCAAATAG AATATGGACT TAAATGTTAA TGAGAAACTG 2880
GCTTTAATCA ATTCTAGCAT TTTATTACTG TAATACAGGG CTGATAGAGT GATTTTGTCT 2940
TATATGAGTC AGTTACTACT TACAGGTGAT AACTTGCATA CTATTGGAAG ATAAAGTTGT 3000
CAAACTTGTC AAGAATGAGA AAAGCCAAAT TAGAAAATCC TATGTCCTAG TTTCCTTACC 3060
AAGGATAATT AAATATATCA CTAAGAGCTT TATATATTGA TTATATATTG TTGACAACTG 3120
GTTTAAGCAT CATAGCCTAT GATGATAAAC ACTGCCTATA TATGTAAATA GCTTTTCATC 3180
AATTCTTAAA TTTCTTAACC TAGGCTTCAG GGAGCATATG AAACCAAAAT TATATGGAAC 3240
ATTTTCTGTG TGTACATGTA CATGCATTTT TCTAGGGAGA GAGTCCGTAG GTTTATCAGA 3300 ATATCAAGGA AAACTGTGAC CCAAAGAAGT TTAAGAATCA CATACAGTGC TGCTGGCTTT 3360
TTGTGCTTGG CAAATGAGTG ACAATAGAAG AAATAATTTT TCTTACACAT TTTAAAACGT 3420
TTTCTCTTCC TTGTGATTGA AGATGAAAGG AGTAAGAAAT TAAGGCATTT GTTTAATTTA 3480
TACTGGTAAC TTATTTAGGG GGGAGGGGAC ATGAAGGTAG GTAAATAGGT AGGCCTCTAA 3540
TTGAACCACC TCTCTAAGTT ATGTACGTAT ATATAAGCTG AAATTGTGTT TGACATTCTG 3600
AGGGTTTTCT TTTTCTTTTT CCTTTTTTTT TTTTTTTGGT GGGGGGCTGG GGGTCAGAGT 3660
CTTGTTCTGT TGCCTGGGCT GGAGTGCAGT GGCATGATCT CAGCTCACTG CAACCTCTGC 3720
CTTCTGGATT CAAGTGATTC TCCTGCCTCA GCCTCTTGAG TAGCTGGGAC TACAGGTGCC 3780
CGCCACCACA CCAGCTAATT TTTGTATTTT TAGTAGAGGC GAAGTTTCCC CATGTTGGCC 3840
AGGCTGGTCT TGAACTCCCG ACCTCAAGTG ATCTGTCTAC CTCGGCCTCC TAAAGTGCTG 3900
AGATTACAGG TGTGAGCCAC CGTGCCCGGC CCATTCTAAG GGTTTTCTTT GAAGACAGGT 3960
CAAATGCTGT TAGTAAGTTT CAGGAGATTG TTAATTCCTC AGTTATACCA GATTTTATAA 4020
AATATTTGAG AATAGATGGC TAACAAGAGG TTAGAAATAC TTTTCCTTAA TTTTAATCCA 4080
CAGTATGTTA CATGCATTCT ACCACTACAT TTTGGTGCTA TTTAAGGTGT GCAATTTTCT 4140
ATAGGTGACT TTTGCAATTC AGGGAAGATT TGGGCATATT AAATGAAAGA ATATCTAATT 4200
GGGGGAGGTG TGAAGGGAAA GAAATTCTTT TCAAAAGCTG ACCACAAAGA GTAGTTAAAA 4260
GTTTTTGTCA CTATCTTCAC AAGTGTGTAA AGCACAGATT TCAACAGAGT GCTTGGCATA 4320
TTGTAGGGTG CTCAATGGTG GTTTTTATTA TTATTACTCA GATTCCACAG TGGCAAGAAA 4380
CATCATTCTA CATAATGGAA AACATTTACA TCAAATCCCA CTTACTTTAA TGCGAACTTG 4440
GAGATAATTT ATGGTATTGT ATTGTAAACC ATTAATGAAA ACTTTTTCAC AGTTGAGTGA 4500 AATTAAAATC ACTATATCTC
Seq ID NO 23 DNA sequence
Nucleic Acid Accession tt NM.006398 1
Coding sequence 19 516
1 11 21 31 41 SI
I I I I I I
GGCCCCTTGT CTGCAGAGAT GGCTCCCAAT GCTTCCTGCC TCTGTGTGCA TGTCCGTTCC 60
GAGGAATGGG ATTTAATGAC CTTTGATGCC AACCCATATG ACAGCGTGAA AAAAATCAAA 120
GAACATGTCC GGTCTAAGAC CAAGGTTCCT GTGCAGGACC AGGTTCTTTT GCTGGGCTCC 180
AAGATCTTAA AGCCACGGAG AAGCCTCTCA TCTTATGGCA TTGACAAAGA GAAGACCATC 2 0
CACCTTACCC TGAAAGTGGT GAAGCCCAGT GATGAGGAGC TGCCCTTGTT TCTTGTGGAG 300
TCAGGTGATG AGGCAAAGAG GCACCTCCTC CAGGTGCGAA GGTCCAGCTC AGTGGCACAA 360
GTGAAAGCAA TGATCGAGAC TAAGACGGGT ATAATCCCTG AGACCCAGAT TGTGACTTGC 420
AATGGAAAGA GACTGGAAGA TGGGAAGATG ATGGCAGATT ACGGCATCAG AAAGGGCAAC 480
TTACTCTTCC TGGCATCTTA TTGTATTGGA GGGTGACCAC CCTGGGGATG GGGTGTTGGC 540
AGGGGTCAAA AAGCTTATTT CTTTTAATCT CTTACTCAAC GAACACATCT TCTGATGATT 600
TCCCAAAATT AATGAGAATG AGATGAGTAG AGTAAGATTT GGGTGGGATG GGTAGGATGA 660
AGTATATTGC CCAACTCTAT GTTTCTTTGA TTCTAACACA ATTAATTAAG TGACATGATT 720 TTTACTAATG TATTACTGAG ACTAGTAAAT AAATTTTTAA GGCAAAATAG AGCATTC
Seq ID NO 24 DNA sequence
Nucleic Acid Accession tt XM_094741 1
Coding sequence 1 948
1 11 21 31 41 51 I I I I I I
ATGAAGGCCA ACTACAGCGC AGAGGAGCGC TTTCTCCTGC TGGGTTTCTC CGACTGGCCT 60
TCCCTGCAGC CGGTCCTCTT CGCCCTTGTC CTCCTGTGCT ACCTCCTGAC CTTGACGGGC 120
AACTCGGCGC TGGTGCTGCT GGCGGTGCGC GACCCGCGCC TGCACACGCC CATGTACTAC 180
TTCCTCTGCC ACCTGGCCTT GGTAGACGCG GGCTTCACTA CTAGCGTGGT GCCGCCGCTG 240
CTGGCCAACC TGCGCGGACC AGCGCTCTGG CTGCCGCGCA GCCACTGCAC GGCCCAGCTG 300
TGCGCATCGC TGGCTCTGGG TTCGGCCGAA TGCGTCCTCC TGGCGGTGAT GGCTCTGGAC 360
CGCGCGGCCG CAGTGTGCCG CCCGCTGCGC TATGCGGGGC TCGTCTCCCC GCGCCTATGT 420
CGCACGCTGG CCAGCGCCTC CTGGCTAAGC GGCCTCACCA ACTCGGTTGC GCAAACCGCG 480
CTCCTGGCTG AGCGGCCGCT GTGCGCGCCC CGCCTGCTGG ACCACTTCAT CTGTGAGCTG 540
CCGGCGTTGC TCAAGCTGGC CTGCGGAGGC GACGGAGACA CTACCGAGAA CCAGATGTTC 600
GCCGCCCGCG TGGTCATCCT GCTGCTGCCG TTTGCCGTCA TCCTGGCCTC CTACGGTGCC 660
GTGGCCCGAG CTGTCTGTTG CATGCGGTTC AGCGGAGGCC GGAGGAGGGC GGTGGGCACG 720
TGTGGGTCCC ACCTGACAGC CGTCTGCCTG TTCTACGGCT CGGCCATCTA CACCTACCTG 780
CAGCCCGCGC AGCGCTACAA CCAGGCACGG GGCAAGTTCG TATCGCTCTT CTACACCGTG 840
GTCACACCTG CTCTCAACCC GCTCATCTAC ACCCTCAGGA ATAAGAAAGT GAAGGGGGCA 900 GCGAGGAGGC TGCTGCGGAG TCTGGGGAGA GGCCAGGCTG GGCAGTGA
Seq ID NO 25 DNA Sequence
Nucleic Acid Accession tt NM_018685 1
Coding sequence 156 .3533
1 11 21 31 41 51
I I I I I I
CTGGAAGCCG AGAGGAGAGG ACAGCTGGTT GTGGGAGAGT TCCCCCGCCT CAGACTCCTG 60
GTTTTTTCCA GGAGACACAC TGAGCTGAGA CTCACTTTTC TCTTCCTGAA TTTGAACCAC 120
CGTTTCCATC GTCTCGTAGT CCGACGCCTG GGGCGATGGA TCCGTTTACG GAGAAACTGC 180
TGGAGCGAAC CCGTGCCAGG CGAGAGAATC TTCAGAGAAA AATGGCTGAG AGGCCCACAG 2 0
CAGCTCCAAG GTCTATGACT CATGCTAAGC GAGCTAGACA GCCACTTTCA GAAGCAAGTA 300
ACCAGCAGCC CCTCTCTGGT GGTGAAGAGA AATCTTGTAC AAAACCATCG CCATCAAAAA 360
AACGCTGTTC TGACAACACT GAAGTAGAAG TTTCTAACTT GGAAAATAAA CAACCAGTTG 420
AGTCGACATC TGCAAAATCT TGTTCTCCAA GTCCTGTGTC TCCTCAGGTG CAGCCACAAG 480
CAGCAGATAC CATCAGTGAT TCTGTTGCTG TCCCGGCATC ACTGCTGGGC ATGAGGAGAG 540
GGCTGAACTC AAGATTGGAA GCAACTGCAG CCTCCTCAGT TAAAACACGT ATGCAAAAAC 600
TTGCAGAGCA ACGGCGCCGT TGGGATAATG ATGATATGAC AGATGACATT CCTGAAAGCT 660
CACTCTTCTC ACCAATGCCA TCAGAGGAAA AGGCTGCTTC CCCTCCCAAA CCTCTGCTTT 720
CAAATGCCTC GGCAACTCCA GTTGGCAGAA GGGGCCGTCT GGCCAATCTT GCTGCAACTA 780
TTTGCTCCTG GGAAGATGAT GTAAATCACT CATTTGCAAA ACAAAACAGT GTACAAGAAC 840
AGCCTGGTAC CGCTTGTTTA TCCAAATTTT CCTCTGCAAG TGGAGCATCT GCTAGGATCA 900
ATAGCAGCAG TGTTAAGCAG GAAGCTACAT TCTGTTCCCA AAGGGATGGC GATGCCTCTT 960
TGAATAAAGC CCTATCCTCA AGTGCTGATG ATGCGTCTTT GGTTAATGCC TCAATTTCCA 1020
GCTCTGTGAA AGCTACTTCT TCTCCAGTGA AATCTACTAC ATCTATCACT GATGCTAAAA 1080
GTTGTGAGGG ACAAAATCCT GAGCTACTTC CAAAAACTCC TATTAGTCCT CTGAAAACGG 1140
GGGTATCGAA ACCAATTGTG AAGTCAACTT TATCCCAGAC AGTTCCATCC AAGGGAGAAT 1200
TAAGTAGAGA AATTTGTCTG CAATCTCAAT CTAAAGACAA ATCTACGACA CCAGGAGGAA 1260
CAGGAATTAA GCCTTTCCTG GAACGCTTTG GAGAGCGTTG TCAAGAACAT AGCAAAGAAA 1320
GTCCAGCTCG TAGCACACCC CACAGAACCC CCATTATTAC TCCAAATACA AAGGCCATCC 1380
AAGAAAGATT ATTCAAGCAA GACACATCTT CATCTACTAC CCATTTAGCA CAACAGCTCA 1440
AGCAGGAACG TCAAAAAGAA CTAGCATGTC TTCGTGGCCG ATTTGACAAG GGCAATATAT 1500
GGAGTGCAGA AAAAGGCGGA AACTCAAAAA GCAAACAACT AGAAACCAAA CAGGAAACTC 1560
ACTGTCAGAG CACTCCCCTC AAAAAACACC AAGGTGTTTC AAAAACTCAG TCACTTCCAG 1620
TAACAGAAAA GGTGACCGAA AACCAGATAC CAGCCAAAAA TTCTAGTACA GAACCTAAAG 1680
GTTTCACTGA ATGCGAAATG ACGAAATCTA GCCCTTTGAA AATAACATTG TTTTTAGAAG 1740
AGGACAAATC CTTAAAAGTA ACATCAGACC CAAAGGTTGA GCAGAAAATT GAAGTGATAC 1800
GTGAAATTGA GATGAGTGTG GATGATGATG ATATCAATAG TTCGAAAGTA ATTAATGACC 1860
TCTTCAGTGA TGTCCTAGAG GAAGGTGAAC TAGATATGGA GAAGAGCCAA GAGGAGATGG 1920
ATCAAGCATT AGCAGAAAGC AGCGAAGAAC AGGAAGATGC ACTGAATATC TCCTCAATGT 1980
CTTTACTTGC ACCATTGGCA CAAACAGTTG GTGTGGTAAG TCCAGAGAGT TTAGTGTCCA 2040
CACCTAGACT GGAATTGAAA GACACCAGCA GAAGTGATGA AAGTCCAAAA CCAGGAAAAT 2100
TCCAAAGAAC TCGTGTCCCT CGAGCTGAAT CTGGTGATAG CCTTGGTTCT GAAGATCGTG 2160
ATCTTCTTTA CAGCATTGAT GCATATAGAT CTCAAAGATT CAAAGAAACA GAACGTCCAT 2220
CAATAAAGCA GGTGATTGTT CGGAAGGAAG ATGTTACTTC AAAACTGGAT GAAAAAAATA 2280
ATGCCTTTCC TTGTCAAGTT AATATCAAAC AGAAAATGCA GGAACTCAAT AACGAAATAA 2340
ATATGCAACA GACAGTGATC TATCAAGCTA GCCAGGCTCT TAACTGCTGT GTTGATGAAG 2400
AACATGGAAA AGGGTCCCTA GAAGAAGCTG AAGCAGAAAG ACTTCTTCTA ATTGCAACTG 2460
GGAAGAGAAC ACTTTTGATT GATGAATTGA ATAAATTGAA GAACGAAGGA CCTCAGAGGA 2520
AGAATAAGGC TAGTCCCCAA AGTGAATTTA TGCCATCCAA AGGATCAGTT ACTTTGTCAG 2580
AAATCCGCTT GCCTCTAAAA GCAGATTTTG TCTGCAGTAC GGTTCAGAAA CCAGATGCAG 2640
CAAATTACTA TTACTTAATT ATACTAAAAG CAGGAGCTGA AAATATGGTA GCCACACCAT 2700
TAGCAAGTAC TTCAAACTCT CTTAACGGTG ATGCTCTGAC ATTCACTACT ACATTTACTC 2760
TGCAAGATGT ATCCAATGAC TTTGAAATAA ATATTGAAGT TTACAGCTTG GTGCAAAAGA 2820
AAGATCCCTC AGGCCTTGAT AAGAAGAAAA AAACATCCAA GTCCAAGGCT ATTACTCCAA 2880
AGCGACTCCT CACATCTATA ACCACAAAAA GCAACATTCA TTCTTCAGTC ATGGCCAGTC 2940
CAGGAGGTCT TAGTGCTGTG CGAACCAGCA ACTTCGCCCT TGTTGGATCT TACACATTAT 3000
CATTGTCTTC AGTAGGAAAT ACTAAGTTTG TTCTGGACAA GGTCCCCTTT TTATCTTCTT 3060
TGGAAGGTCA TATTTATTTA AAAATAAAAT GTCAAGTGAA TTCCAGTGTT GAAGAAAGAG 3120
GTTTTCTAAC CATATTTGAA GATGTTAGTG GTTTTGGTGC CTGGCATCGA AGATGGTGTG 3180
TTCTTTCTGG AAACTGTATA TCTTATTGGA CTTATCCAGA TGATGAGAAA CGCAAGAATC 3240
CCATAGGAAG GATAAATCTG GCTAATTGTA CCAGTCGTCA GATAGAACCA GCCAACAGAG 3300
AATTTTGTGC AAGACGCAAC ACTTTTGAAT TAATTACTGT CCGACCACAA AGAGAAGATG 3360
ACCGAGAGAC TCTTGTCAGC CAATGCAGGG ACACACTCTG TGTTACCAAG AACTGGCTGT 3420
CTGCAGATAC TAAAGAAGAG CGGGATCTCT GGATGCAAAA ACTCAATCAA GTTCTTGTTG 3480
ATATTCGCCT CTGGCAACCT GATGCTTGCT ACAAACCTAT TGGAAAGCCT TAAACCGGGA 3540
AATTTCCATG CTATCTAGAG GTTTTTGATG TCATCTTAAG AAACACACTT AAGAGCATCA 3600
GATTTACTGA TTGCATTTTA TGCTTTAAGT ACGAAAGGGT TTGTGCCAAT ATTCACTACG 3660 TATTATGCAG TATTTATATC TTTTGTATGT AAAACTTTAA CTGATTTCTG TCATTCATCA 3720
ATGAGTAGAA GTAAATACAT TATAGTTGAT TTTGCTAAAT CTTAATTTAA AAGCCTCATT 3780
TTCCTAGAAA TCTAATTATT CAGTTATTCA TGACAATATT TTTTTAAAAG TAAGAAATTC 3840
TGAGTTGTCT TCTTGGAGCT GTAGGTCTTG AAGCAGCAAC GTCTTTCAGG GGTTGGAGAC 3900
AGAAACCCAT TCTCCAATCT CAGTAGTTTT TTCGAAAGGC TGTGATCATT TATTGATCGT 3960
GATATGACTT GTTACTAGGG TACTGAAAAA AATGTCTAAG GCCTTTACAG AAACATTTTT 4020
AGTAATGAGG ATGAGAACTT TTTCAAATAG CAAATATATA TTGGCTTAAA GCATGAGGCT 4080
GTCTTCAGAA AAGTGATGTG GACATAGGAG GCAATGTGTG AGACTTGGGG GTTCAATATT 4140
TTATATAGAA GAGTTAATAA GCACATGGTT TACATTTACT CAGCTACTAT ATATGCAGTG 4200
TGGTGCACAT TTTCACAGAA TTCTGGCTTC ATTAAGATCA TTATTTTTGC TGCGTAGCTT 4260
ACAGACTTAG CATATTAGTT TTTTCTACTC CTACAAGTGT AAATTGAAAA ATCTTTATAT 4320
TAAAAAAGTA AACTGT ATG AAGCTGCTAT GTACTAATAA TACTTTGCTT GCCAAAGTGT 4380
TTGGGTTTTG TTGTTGTTTG TTTGTTTGTT TGTTTTTGGT TCATGAACAA CAGTGTCTAG 4440
AAACCCATTT TGAAAGTGGA AAATTATTAA GTCACCTATC ACCTTTAAAC GCCTTTTTTT 4500
AAAATTATAA AATATTGTAA AGCAGGGTCT CAACTTTTAA ATACACTTTG AACTTCTTCT 4560
CTGAATTATT AAAGTTCTTT ATGACCTCAT TTATAAACAC TAAATTCTGT CACCTCCTGT 4620
CATTTTATTT TTTATTCATT CAAATGTATT TTTTCTTGTG CATATTATAA AAATATATTT 4680
TATGAGCTCT TACTCAAATA AATACCTGTA AATGTCTAAA GG 4722
Seq ID NO. 26 DNA Sequence
Nucleic Acid Accession tt - NM_018098.4
Coding sequence: 29..2680
1 11 21 31 41 51
I I I I I I
AGAGTGCTGA TTTAGAAGAA TACAAATCAT GGCTGAAAAT AGTGTATTAA CATCCACTAC 60
TGGGAGGACT AGCTTGGCAG ACTCTTCCAT TTTTGATTCT AAAGTTACTG AGATTTCCAA 120
GGAAAACTTA CTTATTGGAT CTACTTCATA TGTAGAAGAA GAGATGCCTC AGATTGAAAC 180
AAGAGTGATA TTGGTTCAAG AAGCTGGAAA ACAAGAAGAA CTTATAAAAG CCTTAAAGGA 240
CATTAAAGTG GGCTTTGTAA AGATGGAGTC AGTGGAAGAA TTTGAAGGTT TGGATTCTCC 300
GGAATTTGAA AATGTATTTG TAGTCACGGA CTTTCAGGAT TCTGTCTTTA ATGACCTCTA 360
CAAGGCTGAT TGTAGAGTTA TTGGACCACC AGTTGTATTA AATTGTTCAC AAAAAGGAGA 420
GCCTTTGCCA TTTTCATGTC GCCCGTTGTA TTGTACAAGT ATGATGAATC TAGTACTATG 480
CTTTACTGGA TTTAGGAAAA AAGAAGAACT AGTCAGGTTG GTGACATTGG TCCATCACAT 540
GGGTGGAGTT ATTCGAAAAG ACTTTAATTC AAAAGTTACA CATTTGGTGG CAAATTGTAC 600
ACAAGGAGAA AAATTCAGGG TTGCTGTGAG TCTAGGTACT CCAATTATGA AGCCAGAATG 660
GATTTATAAA GCTTGGGAAA GGCGGAATGA ACAGGATTTC TATGCAGCAG TTGATGACTT 720
TAGAAATGAA TTTAAAGTTC CTCCATTTCA AGATTGTATT TTAAGTTTCC TGGGATTTTC 780
AGATGAAGAG AAAACCAATA TGGAAGAAAT GACTGAAATG CAAGGAGGTA AATATTTACC 840
GCTTGGAGAT GAAAGATGCA CTCACCTTGT AGTTGAAGAG AATATAGTAA AAGATCTTCC 900
CTTTGAACCT TCAAAGAAAC TTTATGTTGT CAAGCAAGAG TGGTTCTGGG GAAGCATTCA 960
AATGGATGCC CGAGCTGGAG AAACTATGTA TTTATATGAA AAGGCAAATA CTCCTGAGCT 1020
CAAGAAATCA GTGTCAATGC TTTCTCTAAA TACCCCTAAC AGCAATCGCA AACGACGTCG 1080
TTTAAAAGAA ACACTTGCTC AGCTTTCAAG AGAGACAGAC GTGTCACCAT TTCCACCCCG 1140
TAAGCGCCCA TCAGCTGAGC ATTCCCTTTC CATAGGGTCA CTCCTAGATA TCTCCAACAC 1200
ACCAGAGTCT AGCATTAACT ATGGAGACAC CCCAAAGTCT TGTACTAAGT CTTCTAAAAG 1260
CTCCACTCCA GTTCCTTCAA AGCAGTCAGC AAGGTGGCAA GTTGCAAAAG AGCTTTATCA 1320
AACTGAAAGT AATTATGTTA ATATATTGGC AACAATTATT CAGTTATTTC AAGTACCATT 1380
GGAAGAGGAA GGACAACGTG GTGGACCTAT CCTTGCACCA GAGGAGATTA AGACTATTTT 1440
TGGTAGCATC CCAGATATCT TTGATGTACA CACTAAGATA AAGGATGATC TTGAAGACCT 1500
TATAGTTAAT TGGGATGAGA GCAAAAGCAT TGGTGACATT TTTCTGAAAT ATTCAAAAGA 1560
TTTGGTAAAA ACCTACCCTC CCTTTGTAAA CTTCTTTGAA ATGAGCAAGG AAACAATTAT 1620
TAAATGTGAA AAACAGAAAC CAAGATTTCA TGCTTTTCTC AAGATAAACC AAGCAAAACC 1680
AGAATGTGGA CGGCAGAGCC TTGTTGAACT TCTTATCCGA CCAGTACAGA GGTTACCCAG 1740
TGTTGCATTA CTTTTAAATG ATCTTAAGAA GCATACAGCT GATGAAAATC CAGACAAAAG 1800
CACTTTAGAA AAAGCTATTG GATCACTGAA GGAAGTAATG ACGCATATTA ATGAGGATAA 1860
GAGAAAAACA GAAGCTCAAA AGCAAATTTT TGATGTTGTT TATGAAGTAG ATGGATGCCC 1920
AGCTAATCTT TTATCTTCTC ACCGAAGCTT AGTACAGCGG GTTGAAACAA TTTCTCTAGG 1980
TGAGCACCCC TGTGACAGAG GAGAACAAGT AACTCTCTTC CTCTTCAATG ATTGCCTAGA 2040
GATAGCAAGA AAACGGCACA AGGTTATTGG CACTTTTAGG AGTCCTCATG GCCAAACCCG 2100
ACCCCCAGCT TCTCTTAAGC ATATTCACCT AATGCCTCTT TCTCAGATTA AGAAGGTATT 2160
GGACATAAGA GAGACAGAAG ATTGCCATAA TGCTTTTGCC TTGCTTGTGA GGCCACCAAC 2220
AGAGCAGGCA AATGTGCTAC TCAGTTTCCA GATGACATCA GATGAACTTC CAAAAGAAAA 2280
CTGGCTAAAG ATGCTGTGTC GACATGTAGC TAACACCATT TG AAAGCAG ATGCTGAGAA 2340
TCTTATTTAT ACTGCTGATC CAGAATCCTT TGAAGTAAAT ACAAAAGATA TGGACAGTAC 2 00
ATTGAGTAGA GCATCAAGAG CAATAAAAAA GACTTCAAAA AAGGTTACAA GAGCATTCTC 2460
TTTCTCCAAA ACTCCAAAAA GAGCTCTTCG AAGGGCTCTT ATGACATCCC ACGGCTCAGT 2S20
GGAGGGAAGA AGTCCTTCCA GCAATGATAA GCATGTAATG AGTCGTCTTT CTAGCACATC 2580
ATCATTAGCA GGTATCCCTT CTCCCTCCCT TGTCAGCCTT CCTTCCTTCT TTGAAAGGAG 2640
AAGTCATACG TTAAGTAGAT CTACAACTCA TTTGATATGA AGCGTTACCA AAATCTTAAA 2700
TTATAGAAAT GTATAGACAC CTCATACTCA AATAAGAAAC TGACTTAAAT GGTACTTGTA 2760
ATTAGCACTT GGTGAAAGCT GGAAGGAAGA TAAATAACAC TAAACTATGC TATTTGATTT 2820
TTCTTCTTGA AAGAGTAAGG TTTACCTGTT ACATTTTCAA GTTAATTCAT GTAAAAAATG 2880
ATAGTGATTT TGATGTAATT TATCTCTTGT TTGAATCTGT CATTCAAAGG CCAATAATTT 2940
AAGTTGCTAT CAGCTGATAT TAGTAGCTTT GCAACCCTGA TAGAGTAAAT AAATTTTATG 3000
GGCGGGTGCC AAATACTGCT GTGAATCTAT TTGTATAGTA TCCATGAATG AATTTATGGA 3060
AATAGATATT TGTGCAGCTC AATTTATGCA GAGATTAAAT GACATCATAA TACTGGATGA 3120
AAACTTGCAT AGAATTCTGA TTAAATAGTG GGTCTGTTTC ACATGTGCAG TTTGAAGTAT 3180
TTAAATAACC ACTCCTTTCA CAGTTTATTT TCTTCTCAAG CGTTTTCAAG ATCTAGCATG 3240
TGGATTTTAA AAGATTTGCC CTCATTAACA AGAATAACAT TTAAAGGAGA TTGTTTCAAA 3300
ATATTTTTGC AAATTGAGAT AAGGACAGAA AGATTGAGAA ACATTGTATA TTTTGCAAAA 60
ACAAGATGTT TGTAGCTGTT TCAGAGAGAG TACGGTATAT TTATGGTAAT TTTATCCACT 3 20
AGCAAATCTT GATTTAGTTT GATAGTGTGT GGAATTTTAT TTTGAAGGAT AAGACCATGG 3480
GAAAATTGTG GTAAAGACTG TTTGTACCCT TCATGAAATA ATTCTGAAGT TGCCATCAGT 3540
TTTACTAATC TTCTGTGAAA TGCATAGATA TGCGCATGTT CAACTTTTTA TTGTGGTCTT 3600 ATAATTAAAT GTAAAATTGA AAATTCATTT GCTGTTTCAA AGTGTGATAT CTTTCACAAT 3660
AGCCTTTTTA TAGTCAGTAA TTCAGAATAA TCAAGTTCAT ATGGATAAAT GCATTTTTAT 3720
TTCCTATTTC TTTAGGGAGT GCTACAAATG TTTGTCACTT AAATTTCAAG TTTCTGTTTT 3780
AATAGTTAAC TGACTATAGA TTGTTTTCTA TGCCATGTAT GTGCCACTTC TGAGAGTAGT 3840
AAATGACTCT TTGCTACATT TTAAAAGCAA TTGTATTAGT AAGAACTTTG TAAATAAATA 3900
CCTAAAACCC AAGTGT 3916
Seq ID NO 27 DNA Sequence
Nucleic Acid Accession tt NM_002497 1
Coding sequence 135 1472
1 11 21 31 41 51
I I I I I I
GGCACGAGTA GGGGTGGCGG GTCAGTGCTG CTCGGGGGCT TCTCCATCCA GGTCCCTGGA 60
GTTCCTGGTC CCTGGAGCTC CGCACTTGGC GCGCAACCTG CGTGAGGCAG CGCGACTCTG 120
GCGACTGGCC GGCCATGCCT TCCCGGGCTG AGGACTATGA AGTGTTGTAC ACCATTGGCA 180
CAGGCTCCTA CGGCCGCTGC CAGAAGATCC GGAGGAAGAG TGATGGCAAG ATATTAGTTT 240
GGAAAGAACT TGACTATGGC TCCATGACAG AAGCTGAGAA ACAGATGCTT GTTTCTGAAG 300
TGAATTTGCT TCGTGAACTG AAACATCCAA ACATCGTTCG TTACTATGAT CGGATTATTG 360
ACCGGACCAA TACAACACTG TACATTGTAA TGGAATATTG TGAAGGAGGG GATCTGGCTA 420
GTGTAATTAC AAAGGGAACC AAGGAAAGGC AATACTTAGA TGAAGAGTTT GTTCTTCGAG 480
TGATGACTCA GTTGACTCTG GCCCTGAAGG AATGCCACAG ACGAAGTGAT GGTGGTCATA 540
CCGTATTGCA TCGGGATCTT AAACCAGCCA ATGTTTTCCT GGATGGCAAG CAAAACGTCA 600
AGCTTGGAGA CTTTGGGCTA GCTAGAATAT TAAACCATGA CACGAGTTTT GCAAAAACAT 660
TTGTTGGCAC ACCTTATTAC ATGTCTCCTG AACAAATGAA TCGCATGTCC TACAATGAGA 720
AATCAGATAT CTGGTCATTG GGCTGCTTGC TGTATGAGTT ATGTGCATTA ATGCCTCCAT 780
TTACAGCTTT TAGCCAGAAA GAACTCGCTG GGAAAATCAG AGAAGGCAAA TTCAGGCGAA 840
TTCCATACCG TTACTCTGAT GAATTGAATG AAATTATTAC GAGGATGTTA AACTTAAAGG 900
ATTACCATCG ACCTTCTGTT GAAGAAATTC TTGAGAACCC TTTAATAGCA GATTTGGTTG 960
CAGACGAGCA AAGAAGAAAT CTTGAGAGAA GAGGGCGACA ATTAGGAGAG CCAGAAAAAT 1020
CGCAGGATTC CAGCCCTGTA TTGAGTGAGC TGAAACTGAA GGAAATTCAG TTACAGGAGC 1080
GAGAGCGAGC TCTCAAAGCA AGAGAAGAAA GATTGGAGCA GAAAGAACAG GAGCTTTGTG 1140
TTCGTGAGAG ACTAGCAGAG GACAAACTGG CTAGAGCAGA AAATCTGTTG AAGAACTACA 1200
GCTTGCTAAA GGAACGGAAG TTCCTGTCTC TGGCAAGTAA TCCAGAACTT CTTAATCTTC 1260
CATCCTCAGT AATTAAGAAG AAAGTTCATT TCAGTGGGGA AAGTAAAGAG AACATCATGA 1320
GGAGTGAGAA TTCTGAGAGT CAGCTCACAT CTAAGTCCAA GTGCAAGGAC CTGAAGAAAA 1380
GGCTTCACGC TGCCCAGCTG CGGGCTCAAG CCCTGTCAGA TATTGAGAAA AATTACCAAC 1440
TGAAAAGCAG ACAGATCCTG GGCATGCGCT AGCCAGGTAG AGAGACACAG AGCTGTGTAC 1500
AGGATGTAAT ATTACCAACC TTTAAAGACT GATATTCAAA TGCTGTAGTG TTGAATACTT 1560
GGCCCCATGA GCCATGCCTT TCTGTATAGT ACACATGATA TTTCGGAATT GGTTTTACTG 1620
TTCTTCAGCA ACTATTGTAC AAAATGTTCA CATTTAATTT TTCTTTCTTC TTTTAAGAAC 1680
ATATTATAAA AAGAATACTT TCTTGGTTGG GCTTTTAATC CTGTGTGTGA TTACTAGTAG 1740
GAACATGAGA TGTGACATTC TAAATCTTGG GAGAAAAAAT AATATTAGGA AAAAAATATT 1800
TATGCAGGAA GAGTAGCACT CACTGAATAG TTTTAAATGA CTGAGTGGTA TGCTTACAAT 1860
TGTCATGTCT AGATTTAAAT TTTAAGTCTG AGATTTTAAA TGTTTTTGAG CTTAGAAAAC 1920
CCAGTTAGAT GCAATTTGGT CATTAATACC ATGACATCTT GCTTATAAAT ATTCCATTGC 1980
TCTGTAGTTC AAATCTGTTA GCTTTGTGAA AATTCATCAC TGTGATGTTT GTATTCTTTT 2040
TTTTTTTCTG TTTAACAGAA TATGAGCTGT CTGTCATTTA CCTACTTCTT TCCCACTAAA 2100
TAAAAGAATT CTTCAGTTA 2119
Seq ID NO 28 DNA Sequence
Nucleic Acid Accession tt Eos sequence
1 11 21 31 41 51
I I I I I I
GGGAGCTACA ATGTTTTGTC ATTATTCACT CTGATGTGAA AAAGGCAGTG AATTTAATAG 60
AAAATAACTT CGTAGAGCAA AATCTCAGGT GTGTTTTTTT AGTGCCGCAG TCTTGGATGA 120
TGGGTTCCTA GAAGCTCTCA ACATCTCTTC TTAATTGGAG AAAGTGTTAA GCCCCAAAGT 180
AGCTGGAGCA GTACATCTTC AATTTTTGAC AAGAAAACAG GAACTTGATT ACTTTGAGTG 240
CTATTCATTA GTTTCTGCTT TCATTGAGAA TGCAACAAAA GCCAACTAGG CTGCTGCTAA 300
CTCCTTGCNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 360 CTAGGGAGTC TTTCATCTTG AGTGAC CT GCACAAATGA TCTTCAAAGC ATTTTAGCCA 420
CCAGAGGAAT TCTCTTGAAA TACCCAAAAT CCATCAGTAT CTTGAATCAT GCTGGATTTT 480
GAAGAATTCT TAACAAGCCA TGTAAAGGGG GCTCTCTGGC CTTGAAATAG TGATGTTTTT 540
TATACAGAAA GGAGAATGCA GAATGGTCAG ACTACCATGC ACTGTTAAAT TTGATTTCAA 600
GAAATTACAG GAAAACTTTC CAAAGTTCCA TCTCACAGAA ATTATTTTTA CAAAGAATTC 660 CAAGATAAGT TTAGTTTTAT GGAAGACTTT TATGTGGTTT TTACTCACTC TTCATCTCAG 720
ACATCAACAG ATGATTACAT CACTTATTTA GCTAGTAAAT TTATTAATAT AAAAACTCAG 780
AGACATTCCA ATATCCACAT TGCTTACACC ATTAGGCATA GATTCAGTGT CAGCTATGAC 840
AATTGAAAAT AAGCTGTTTT GTGATTTAAA GGTTTAAATT TCTCTAACCA AACTGCTTGA 900
TCCAGATGCA GGACTGCAAA TGTTAATATT TGTTCTGGAA GAACAATCAA ATAAGACTTA 960
AGAGGAAAAG GAATGGCCAC AATCCACCTG AAATTTTTTT TTAAAAAGTG TGCAGCCTAC 1020
TAAATCAGAA TGAAAATAGA AGTACAAGAT TATAAACAAA ATGCAATCAA ACTTTTCTTA 1080
AGCTTACCTA AAGTTATTTC ATCTGAAAAT TTCAAGCAAC TTTGTTCAAC ATTAAATTGA 1140
CAATCTAAAC TAACAAGTCT TTTGAATTTA TGCATGGTAG TAAACATTCT CTCTATTAAC 1200
TGTATTACCT AAGGCTAAAC CTAAAATTTT TAAGCAAAAT TAGAAAAATA GTCTTCACTC 1260
ATCAAAAAAT AAAGTTTGTT ACATTTAGTA TTTTCCCAAG AAAAAAAAAA AAAAAAAAAA 1320
AAAAAAAAAA AGAGTCTGTG CAAAATGTCA CTAAAAATAA ATTAGCACTA GAAATTATTT 1380
CTAAATACCA AAAAAAAAAA AAAATTGAGA TGGGTTTCCC AAGGAAAACA CTCGCAATCA 1440 AACAACAAAA ACAAAGAACA AAAAAGAATA GACAAAAAGA 1480 Seq ID NO 29 DNA Sequence
Nucleic Acid Accession Eos sequence
1 11 21 31 41 51
I I I I I I
TCCCTGCAGC TGTGTTTGAA CAGGTCATTT ACCATGCTGT CCTCCAGGTT CAACAGTATG 60 GCTCCAAAGG ATGAAATTTC ATTCTGATTT TCTGGCTGAA GACTATTCTC TTTGTGTATG 120
TCCACCACAG TTACTTTATC CCTTCATCTG TGGATGGGCA GGAAACTCCA AACTGTCCAA 180
GGAGATAGTT CTGTTGTGAT TACTTCATTG AGAAATTTAA CTTATGAGCA GTTGAAAGGA 240
ATGCAAGTTG CTGCAAAATC AGAATGAAGA GTGCAAAACG ASSRAGCTAC AATGTTTTGT 300 CATTATTCAC TCTGATGTGA AAAAGGCAGT GAATTTAATA GAAAATAACT TCGTAGAGYA 360
AAATCTCAGG TGTGTTTTTT TAGTGCCGCA GTCTTGGATG ATGGGTTCCT AGAAGCTCTC 420
AAACATCTCT TCTTAATTGG AGAAAGTGTT AAGCCCCAAA GTAGCTGGAG CAGTACATCT 480
TCAATTTTTG ACAAGAAAGC AGGAACTTGA TTACTTTGAG TGCTATTCAT TAGTTTCTGC 5 0
TTTCATTGAG AATGCAACAA AAGCCAACTA GGCTGCTGCT AACTCCTTGC TGGACTTCTT 600 CTGCCACTGT CACAGGAACT GTAATCTCAC TGGACAATTA ACTAGGGAGT CTTTCATCTT 660
GAGTGACTGC TGCACAAATG ATCTTCAAAG CATTTTAGCC ACCAGAGGAA TTCTCTTGAA 720
ATACCCAAAA TCCATCAGTA TCTTGAATCA TGCTGGATTT TGAAGAATTC TTAACAAGCC 780
ATGTAAAGGG GGCTCTCTGG CCTTGAAATA GTGATGTTTT TTATACAGAA AGGAGAATGC 840
AGAATGGTCA GACTACCATG CACTGTTAAA TTTGATTTCA AGAAATTACA GGAAAACTTT 900 CCAAAGTTCC ATCTCACAGA AATTATTTTT ACAAAGAATT CCAAGATAAG TTTAGTTTTA 960
TGGAAGACTT TTATGTGGTT TTTACTCACT CTTCATCTCA GACATCAACA GATGATTACA 1020
TCACTTATTT AGCTAGTAAA TTTATTAATA TAAAAACTCA GAGACATTCC AATATCCACA 1080
TTGCTTACAC CATTAGGCAT AGATTCAGTG TCAGCTATGA CAATTGAAAA TAAGCTGTTT 1140
TGTGATTTAA AGGTTTAAAT TTCTCTAACC AAACTGCTTG ATCCAGATGC AGGACTGCAA 1200 ATGTTAATAT TTGTTCTGGA AGAACAATCA AATAAGACTT AAGAGGAAAA GGAATGGCCA 1260
CAATCCACCT GAAAATTTTT TTTTAAAAAG TGTGCAGCCT ACTAAATCAG AATGAAAATA 1320
GAAGTACAAG ATTATAAACA AAATGCAATC AAACTTTTCT TAAGCTTACC TAAAGTTATT 1380
TCATCTGAAA ATTTCAAGCA ACTTTGTTCA ACATTAAATT GACAATCTAA ACTAACAAGT 1440
CTTTTGAATT TATGCATGGT AGTAAACATT CTCTCTATTA ACTTTATTAC CTAAGGCTAA 1500 ACCTAAAATT TTTAAGCAAA ATTAGAAAAA TAGTCTTCAC TCATCAAAAA ATAAAGTTTG 1560
TTACATTTAG TATTTTCCCA AT 1S82
Seq ID NO 30 DNA Sequence Nucleic Acid Accession tt Eos sequence Coding sequence 817
1 11 21 31 41 51
I I I I I I
AGATATATCA TACGAAAATG AAAATTATAA TTCTTCTTGG ATTCCTGGGA GCCACATTGT 60
CAGCCCCAGT TTACTTCTTA ATCTTAATAA TGGTCAACTT TTGCCACTAC AACTTCAGGG 120 CCCACTTAAT TCATGGATTC CACCTTTCTC TGGAATTTTA CAACAGCAGC AGCAGGCTCA 180
AATTCCAGGA CTCTCCCAGT TCTCTTTATC AGCTCTAGAC CAGTTTGCTG GACTGCTCCC 240
AAATCAGATA CCCTTAACAG GAGAGGCCAG TTTTGCCCAA GGAGCCCAGG CAGGCCAAGT 300
TGATCCCTTA CAGCTTCAAA CACCGCCTCA GACACAACCA GGCCCCAGTC ACGTGATGCC 360
CTATGTATTC TCCTTCAAAA TGCCTCAAGA GCAAGGACAG ATGTTTCAAT ACTATCCAGT 420 TTACATGGTC CTACCCTGGG AACAACCTCA GCAAACAGTT CCAAGGTCAC CTCAACAAAC 480
AAGACAGCAA CAGTATGAGG AGCAGA ACC ATTCTATGCT CAATTTGGAT ACATTCCACA 540
ACTAGCAGAA CCTGCTATAT CAGGAGGACA GCAGCAACTA GCTTTTGATC CCCAACTAGG 600
CACAGCTCCT GAAATTGCTG TGATGTCAAC AGGAGAAGAG ATACCATATT TACAAAAAGA 660
AGCGATCAAC TTTAGACATG ACAGTGCAGG AGTTTTCATG CCCTCAACTT CACCAAAACC 720 CAGCACAACC AATGTTTTCA CTTCTGCTGT AGACCAAACT ATTACCCCAG AGCTCCCAGA 780
AGAGAAGGAC AAGACTGACA GCCTAAGGGA ACCATAA 817
Seq ID NO 31 DNA Sequence Nucleic Acid Accession tt Eos sequence Coding sequence 917
1 11 21 31 41 51
I I I I I I
AGAGAGGAAA AGAACACAGA TCTCGCATGG TTCAGATTTT TCTTTTTAGG TCCAGGAGTA 60
AGATATATCA TACGAAAATG AAAATTATAA TTCTTCTTGG ATTCCTGGGA GCCACATTGT 120
CAGCCCCACT TATCCCACAG CGTCTCATGT CTGCCAGCAA TAGCAATGAG TTACTTCTTA 180
ATCTTAATAA TGGTCAACTT TTGCCACTAC AACTTCAGGG CCCACTTAAT TCATGGATTC 240
CACCTTTCTC TGGAATTTTA CAACAGCAGC AGCAGGCTCA AATTCCAGGA CTCTCCCAGT 300
TCTCTTTATC AGCTCTAGAC CAGTTTGCTG GACTGCTCCC AAATCAGATA CCCTTAACAG 360
GAGAGGCCAG TTTTGCCCAA GGAGCCCAGG CAGGCCAAGT TGATCCCTTA CAGCTTCAAA 420
CACCGCCTCA GACACAACCA GGCCCCAGTC ACGTGATGCC CTATGTATTC TCCTTCAAAA 480
TGCCTCAAGA GCAAGGACAG ATGTTTCAAT ACTATCCAGT TTACATGGTC CTACCCTGGG 540
AACAACCTCA GCAAACAGTT CCAAGGTCAC CTCAACAAAC AAGACAGCAA CAGTATGAGG 600
AGCAGATACC ATTCTATGCT CAATTTGGAT ACATTCCACA ACTAGCAGAA CCTGCTATAT 660
CAGGAGGACA GCAGCAACTA GCTTTTGATC CCCAACTAGG CACAGCTCCT GAAATTGCTG 720
TGATGTCAAC AGGAGAAGAG ATACCATATT TACAAAAAGA AGCGATCAAC TTTAGACATG 780
ACAGTGCAGG AGTTTTCATG CCCTCAACTT CACCAAAACC CAGCACAACC AATGTTTTCA 840
CTTCTGCTGT AGACCAAACT ATTACCCCAG AGCTCCCAGA AGAGAAGGAC AAGACTGACA 900
GCCTAAGGGA ACCATAA 917
Seq ID NO 32 DNA Sequence
Nucleic Acid Accession tt Eos sequence
1 11 21 31 41 51
I I I I I I ττττττττττ TTTTTGTAGA GATGGGGTCT CACTTTGTTG CCCATGCTTT GGCTGCTCTT 60
CAAGATTTAG CACTTCTGAG CTGTTGCTTT TGTCTCCAGT CTACCCTGAG CAGTTCTTAA 120
GGTGTTTGAA GCAGAAGAAA GAGAAAAGAG GCTTAGGTTA TACTGCTTAG AACCTCCTCT 180
TCAACTAACC TACCGACCCA CCTACCCATA AATCCA ACC TACACACACA CCCCTTTCCT 240
TTCCTCTGCC CTGGTTTTGC CTCGCCTGCT TTCAATTGCA CGTGTGTTGA GTATAGCCTT 300
TGCCTCTGCC TACTCAGCTC CTTGAACTGA GGGTGAAATT GAGACCCAGA GGAATGGGAT 360
TTACAGCTTC TTGCTTTCTT CTTGCCTTGT CCTAGAACTG AAGTACAAAT GGGAAGAAGC 420
TTTGATGAAG GAAGACCCCC ATCCAAGAAC ATCTAGTTTT CAGGTGCCAT AACAGCAGAG 480
CAAGTTCA 488
Seq ID NO 33 DNA Sequence Nucleic Acid Accession tt Eos sequence
1 11 21 31 41 51
I I I I I I
CTCCCAGAGT GCTAGGATTA CAGGCATGAG CCACTGCTCC CAGCCTTCCA GAGGAATTTT 60
AAGCCCATGT CCAAACATTC TGTTTGTATA AATATATTCT AATTTTTAAA TAAATAGTTT 120
CTACTTTTCT GAACTTTATA TTTTTTCTTG CTATAATGGA TTTTCA AAT CAGAAAAGAT 180
TAAATTAGTA ATCATGAATT GCCTTCAATA TTTGGCAGTA AGTCAATGAA ATAAT AGGC 240
ACTTATATAC CATCTTTGAC ATCATTAAAA GTATCAAATC CCATTAATCT AAAACTTCTT 300
TAAGCATTTT GAAAGCAGAA AATGTTTACA TGGTTCTTTC AGTTCCTCAG GCTTTTTGTC 360
TAATGATGCG TGACTTAGGA TAAGATTTGA ATTAAGTGCC CAGCTTGAAA CATAATAATT 420
TTTCTGTATA AGCCACAGAT CCTCTACCTC CTTTGTGTTA AAGCCTTTAT ATGAAACAAT 480
TAAGTAGAAG CATTCAATAG TGTGTCATTA ACTGTTCATA CTAATAAATG GATACAGCAC 540
ATTTTCATGG CCTGTAATGT AGAACATACT ATATAAAGTT CTCAGTTTGG GGATGACTAG 600
GTTTCTGGAA GGAATAGAAT GCTAAATCAA TGGATGGCAT TGGGCTGAGA AACACTGCTG 660
CTACTAATCA GCCTTGAATG TGTAATGTGA ACATGCAAAA GAGAACATGC ATACACTCAA 720
ATTTGTACAA TGCTATAACT GGAAGTTGAA GGACTTGAAT TTTTATATTG TGCTATTGTT 780
ATGTTTTCTG TAATTGTTTA TATCTAAGGA ATTTTTGAGG TAATATAAAA GAAAAAGAGA 840
ATAATGAACA ATGATGTCAC TGGAGGGTTT TTACATTAAA TTAGATCATT TTTCTTCTTA 900
TTCACAATAA TAATCTTAAT CTTTAAGAAT TAATTATAAT TTAATATTAT AATTCATAAT 960
CTTTAAGAAT TAATAATTAT AATTTAATAT TATAATTAAT AATCTTTAAG AATTAATAAT 1020
ATAATTTAAT ATTATAATTA ATAATCTTTA AGAATTAATA ATTACAATTA ATAATTAATA 1080
ATAATCTTAA TCTTTAAGAA TTAATAATAA TCCTTAATCG CAATAATAAT CGCAAGGAGG 1140
AGAAGTAAGT CCCTCCTCCT TCTGTATGAA CTTTTCTCCC ACATGCTGCT GTATGGTTTA 1200
GTGAGAGTGA AGTTCTAAAG AACATCAATA TGATTGGTGG GATAATCCAA AGACATTTTT 1260
TCAGAATCAA ATGGCATGTC GAAGGTTTGT TTCTTGCATA TGTATTTACT GGTCCACAGC 1320
ACAAAATAAA GTGACCACAT ATACATAGGA AAGTTGAATT TGTACACATA CAGCATCTGA 1380
AATGTATCTG ATGTTCAGCA TCAAGATTTC ACTGAACATT GTAGAAATGT GTATCTTTTG 1440
CATGTATATT TTACATTGAT TTTCTATTTA TGTACATCTA GAAAGTTTTA ACCCTAATAA 1500
ATAGTTTTGT AATTTTGAAT AATAGTGTCA GTTTATATGT GAGGGAGTAG AGACAGAGAG 1560
GTTAGCACTG GATAATAATT AGTAAGGCCA AAGGAGAAAA TTTCATAGAA AATATTGTTG 1620
TTGTCATAAT GAGTACAGCA TGAAAGGCTT CCTCTACAAG ACACTAGTCA AAGAGTTGAG 1680
AGCTGCGGTT TCTAATCTTT GTCCATTACT CCCTTACTCC CTATGAGACT GTGGACCTGT 1740
CACTTGGCCT CTCTGGTCTT CAGTTTTCTC ACCAGTAAAA CAAGGAACTT GAACCAAATG 1800
ACCTCTAGTG TTCCCCTTGG GTTTAAATGT CTATAAATGT TCAATGACTA GAATGTATTG 1860
CGTTTTTCTT TATTCTTTTT GCTTTGAGAA AAGAGAATGT GATTTAAGAG TAATAATTTG 1920
AATACCAATT ATCCACATTA AAATTGTGTC CTCTATGTGT AAGGCATAGC ACATTTAGCA 1980
CACATACATA AGCACACTAA GCACCTTACA AATATCCTCA TTTATTCTTT ACATAATCTT 2040
TTGAAATTGA TTATGTAATA CACACTGTTT TTGAACAATT GGTGACTTCC AGCTGTTTAA 2100
AACAAACTAC AGTATGGTGC TTGAGTACTG ACTTAGGAGG TCAGCATTGG TTTCAC AGG 2160
AGCTTCTCAA AGCACGCTGC CAAACATGCT CCAGTCTCAT TGTCAAGGCC TTAGACCAGG 2220
CAATCATTAC GGCAGTGGTT CTTCAACTTC AGCAGCAGCA AAACGATCTG GCGGGGGCTT 2280
GGTGAAACAG ACTGCTGGGC TCGACCACCA GAATTTCTCA TTCAGAGGGT CTGGCCTGAT 2340
CACTTGCATT TCTAATCACT TCCCAGGTGA TGCAGATGTT TCTGGTCCAG GGACCCCAGT 2400
TTGAGAACCA CTGTATTAAA ATTTCCTTCA TCTCTATAGA AATGGAAAGA TTTTTTATAA 2460
GTCCTCTAAT TTGCTTTAAG ATAAATGAGA TTTCACTTAA TTCTGTTGGA GAAATTGTTT 2520
TAAAAATTGT GCTAAAGAAC CGAAAATCAC TTTATGTTAA GGCTCTATTT ATAGCAAGTG 2580
AACTTTTCAT GAGTTAATAA AGGCCTACAA AAATAATTTT GACTGTGAAA CTAATTAAAA 2640
TCTCTGTGTT TCATTTAAAG CATAAACATA TTTGAATAAA AATAGGTTAA CAATAATTTG 2700
GGACATGTAT TCAGTATAAT TTTAAGATAA TTTTACAAAA TATATGTAAC ATTGCATTTG 2760
TTTCTGTAAA ATATCTTCGG AAAAAGCCTT GTTTTCCCTA GTGTGTTATT TGTTGAATTT 2820
CTTGTTAAAT GTATTTTTTC CCATTGAAAA AAATGTTTTT AATCAATGTG ATCAATACAG 2880
CTATCTATAT GCCCTGCTTT CACTGTA 2907
Seq ID NO 34 DNA Sequence
Nucleic Acid Accession It NM_003979 2
Coding sequence 254 1357
1 11 21 31 41 51
I I I I I I
ATAACAGCAT GAAGTGCCGT GGAACTGGAA TAGGCGTGTC CTCTCCCTCG ACCCTCCCCC 60
TCCTTGTCCC TCTGCTCACC CCTCGCTCGT TCCCTCCCTC CGGCGAGGGC CGCCTTTATA 120
ACAACTGCTC AGAGTGCGAG GGCGGGATAG CTGTCCAAGG TCTCCCCCAG CACTGAGGAG 180
CTCGCCTGCT GCCCTCTTGC GCGCGGGAAG CAGCACCAAG TTCACGGCCA ACGCCTTGGC 240
ACTAGGGTCC AGAATGGCTA CAACAGTCCC TGATGGTTGC CGCAATGGCC TGAAATCCAA 00
GTACTACAGA CTTTGTGATA AGGCTGAAGC TTGGGGCATC GTCCTAGAAA CGGTGGCCAC 360
AGCCGGGGTT GTGACCTCGG TGGCCTTCAT GCTCACTCTC CCGATCCTCG TCTGCAAGGT 420
GCAGGACTCC AACAGGCGAA AAATGCTGCC TACTCAGTTT CTCTTCCTCC TGGGTGTGTT 480
GGGCATCTTT GGCCTCACCT TCGCCTTCAT CATCGGACTG GACGGGAGCA CAGGGCCCAC 540
ACGCTTCTTC CTCTTTGGGA TCCTCTTTTC CATCTGCTTC TCCTGCCTGC TGGCTCATGC 600
TGTCAGTCTG ACCAAGCTCG TCCGGGGGAG GAAGCCCCTT TCCCTGTTGG TGATTCTGGG 660
TCTGGCCGTG GGCTTCAGCC TAGTCCAGGA TGTTATCGCT ATTGAATATA TTGTCCTGAC 720
CATGAATAGG ACCAACGTCA ATGTCTTTTC TGAGCTTTCC GCTCCTCGTC GCAATGAAGA 780
CTTTGTCCTC CTGCTCACCT ACGTCCTCTT CTTGATGGCG CTGACCTTCC TCATGTCCTC 840
CTTCACCTTC TGTGGTTCCT TCACGGGCTG GAAGAGACAT GGGGCCCACA TCTACCTCAC 900 GATGCTCCTC TCCATTGCCA TCTGGGTGGC CTGGATCACC CTGCTCATGC TTCCTGACTT 960
TGACCGCAGG TGGGATGACA CCATCCTCAG CTCCGCCTTG GCTGCCAATG GCTGGGTGTT 1020 CCTGTTGGCT TATGTTAGTC CCGAGTTTTG GCTGCTCACA AAGCAACGAA ACCCCATGGA 1080 TTATCCTGTT GAGGATGCTT TCTGTAAACC TCAACTCGTG AAGAAGAGCT ATGGTGTGGA 11 0 GAACAGAGCC TACTCTCAAG AGGAAATCAC TCAAGGTTTT GAAGAGACAG GGGACACGCT 1200 CTATGCCCCC TATTCCACAC ATTTTCAGCT GCAGAACCAG CCTCCCCAAA AGGAATTCTC 1260 CATCCCACGG GCCCACGCTT GGCCGAGCCC TTACAAAGAC TATGAAGTAA AGAAAGAGGG 1320 CAGCTAACTC TGTCCTGAAG AGTGGGACAA ATGCAGCCGG GCGGCAGATC TAGCGGGAGC 1380 TCAAAGGGAT GTGGGCGAAA TCTTGAGTCT TCTGAGAAAA CTGTACAAGA CACTACGGGA 1440 ACAGTTTGCC TCCCTCCCAG CCTCAACCAC AATTCTTCCA TGCTGGGGCT GATGTGGGCT 1S00 AGTAAGACTC CAGTTCTTAG AGGCGCTGTA GTATTTTTTT TTTTTTGTCT CATCCTTTGG 1560 ATACTTCTTT TAAGTGGGAG TCTCAGGCAA CTCAAGTTTA GACCCTTACT CTTTTTGTTT 1620
GTTTTTTGAA ACAGGATCTT GCTCTGTCAC CCAGGCTTGA GTGCAGTGGT GCGATCACAG 1680
CCCAGTGCAG CCTCGACCAC CTGTGCTCAA GCAATCCTCC CATCTCCATC TCCCAAAGTG 1740
CTGGGATGAC AGGCGTGAGC CACAGCTCCC AGCCTAGGCC CTTAATCTTG CTGTTATTTT 1800
CCATGGACTA AAGGTCTGGT CATCTGAGCT CACGCTGGCT CACACAGCTC TAGGGGCCTG 1860
CTCCTCTAAC TCACAGTGGG TTTTGTGAGG CTCTGTGGCC CAGAGCAGAC CTGCATATCT 1920
GAGCAAAAAT AGCAAAAGCC TCTCTCAGCC CACTGGCCTG AATCTACACT GGAAGCCAAC 1980
TTGCTGGCAC CCCCGCTCCC CAACCCTTCT TGCCTGGGTA GGAGAGGCTA AAGATCACCC 2040
TAAATTTACT CATCTCTCTA GTGCTGCCTC ACATTGGGCC TCAGCAGCTC CCCAGCACCA 2100
ATTCACAGGT CACCCCTCTC TTCTTGCACT GTCCCCAAAC TTGCTGTCAA TTCCGAGATC 2160
TAATCTCCCC CTACGCTCTG CCAGGAATTC TTTCAGACCT CACTAGCACA AGCCCGGTTG 2220
CTCCTTGTCA GGAGAATTTG TAGATCATTC TCACTTCAAA TTCCTGGGGC TGATACTTCT 2280
CTCATCTTGC ACCCCAACCT CTGTAAATAG ATTTACCGCA TTTACGGCTG CATTCTGTAA 2340
GTGGGCATGG TCTCCTAATG GAGGAGTGTT CATTGTATAA TAAGTTATTC ACCTGAGTAT 2400
GCAATAAAGA TGTGGTGGCC ACTCTTTCAT GGTGGTGGCA GCAAAAAAAA AAAAAA 2456
Seq ID NO 35 DNA Sequence
Nucleic Acid Accession ti NM.032957 1
Coding sequence 1 4203
1 11 21 31 41 51
I I I I I I
ATGCCCAAGA TAGTCCTGAA TGGTGTGACC GTAGACTTCC CTTTCCAGCC CTACAAATGC 60
CAACAGGAGT ACATGACCAA GGTCCTGGAA TGTCTGCAGC AGAAGGTGAA TGGCATCCTG 120
GAGAGCCCTA CGGGTACAGG GAAGACGCTG TGCCTGCTGT GCACCACGCT GGCCTGGCGA 180
GAACACCTCC GAGACGGCAT CTCTGCCCGC AAGATTGCCG AGAGGGCGCA AGGAGAGCTT 240
TTCCCGGATC GGGCCTTGTC ATCCTGGGGC AACGCTGCTG CTGCTGCTGG AGACCCCATA 300
GCTTGCTACA CGGACATCCC AAAGATTATT TACGCCTCCA GGACCCACTC GCAACTCACA 360
CAGGTCATCA ACGAGCTTCG GAACACCTCC TACCGGCCTA AGGTGTGTGT GCTGGGCTCC 420
CGGGAGCAGC TGTGCATCCA TCCTGAGGTG AAGAAACAAG AGAGTAACCA TCTACAGATC 480
CACTTGTGCC GTAAGAAGGT GGCAAGTCGC TCCTGTCATT TCTACAACAA CGTAGAAGAA 540
AAAAGCCTGG AGCAGGAGCT GGCCAGCCCC ATCCTGGACA TTGAGGACTT GGTCAAGAGC 600
GGAAGCAAGC ACAGGGTGTG CCCTTACTAC CTGTCCCGGA ACCTGAAGCA GCAAGCCGAC 660
ATCATATTCA TGCCGTACAA TTACTTGTTG GATGCCAAGA GCCGCAGAGC ACACAACATT 720
GACCTGAAGG GGACAGTCGT GATCTTTGAC GAAGCTCACA ACGTGGAGAA GATGTGTGAA 780 GAATCGGCAT CCTTTGACCT GACTCCCCAT GACCTGGCTT CAGGACTGGA CGTCATAGAC 840
CAGGTGCTGG AGGAGCAGAC CAAGGCAGCG CAGCAGGGTG AGCCCCACCC GGAGTTCAGC 900
GCGGACTCCC CCAGCCCAGG GCTGAACATG GAGCTGGAAG ACATTGCAAA GCTGAAGATG 960
ATCCTGCTGC GCCTGGAGGG GGCCATCGAT GCTGTTGAGC TGCCTGGAGA CGACAGCGGT 1020
GTCACCAAGC CAGGGAGCTA CATCTTTGAG CTGTTTGCTG AAGCCCAGAT CACGTTTCAG 1080
ACCAAGGGCT GCATCCTGGA CTCGCTGGAC CAGATCATCC AGCACCTGGC AGGACGTGCT 1140
GGAGTGTTCA CCAACACGGC CGGACTGCAG AAGCTGGCGG ACATTATCCA GATTGTGTTC 1200
AGTGTGGACC CCTCCGAGGG CAGCCCTGGT TCCCCAGCAG GGCTGGGGGC CTTACAGTCC 1260
TATAAGGTGC ACATCCATCC TGATGCTGGT CACCGGAGGA CGGCTCAGCG GTCTGATGCC 1320
TGGAGCACCA CTGCAGCCAG AAAGCGAGGG AAGGTGCTGA GCTACTGGTG CTTCAGTCCC 1380
GGCCACAGCA TGCACGAGCT GGTCCGCCAG GGCGTCCGCT CCCTCATCCT TACCAGCGGC 1440
ACGCTGGCCC CGGTGTCCTC CTTTGCTCTG GAGATGCAGA TCCCTTTCCC AGTCTGCCTG 1500
GAGAACCCAC ACATCATCGA CAAGCACCAG ATCTGGGTGG GGGTCGTCCC CAGAGGCCCC 1560
GATGGAGCCC AGTTGAGCTC CGCGTTTGAC AGACGGTTTT CCGAGGAGTG CTTATCCTCC 1620
CTGGGGAAGG CTCTGGGCAA CATCGCCCGC GTGGTGCCCT ATGGGCTCCT GATCTTCTTC 1680
CCTTCCTATC CTGTCATGGA GAAGAGCCTG GAGTTCTGGC GGGCCCGCGA CTTGGCCAGG 1740
AAGATGGAGG CGCTGAAGCC GCTGTTTGTG GAGCCCAGGA GCAAAGGCAG CTTCTCCGAG 1800
ACCATCAGTG CTTACTATGC AAGGGTTGCC GCCCCTGGGT CCACCGGCGC CACCTTCCTG 1860
GCGGTCTGCC GGGGCAAGGC CAGCGAGGGG CTGGACTTCT CAGACACGAA TGGCCGTGGT 1920
GTGATTGTCA CGGGCCTCCC GTACCCCCCA CGCATGGACC CCCGGGTTGT CCTCAAGATG 1980
CAGTTCCTGG ATGAGATGAA GGGCCAGGGT GGGGCTGGGG GCCAGTTCCT CTCTGGGCAG 2040
GAGTGGTACC GGCAGCAGGC GTCCAGGGCT GTGAACCAGG CCATCGGGCG AGTGATCCGG 2100
CACCGCCAGG ACTACGGAGC TGTCTTCCTC TGTGACCACA GGTTCGCCTT TGCCGACGCA 2160
AGAGCCCAAC TGCCCTCCTG GGTGCGTCCC CACGTCAGGG TGTATGACAA CTTTGGCCAT 2220
GTCATCCGAG ACGTGGCCCA GTTCTTCCGT GTTGCCGAGC GAACTATGCC AGCGCCGGCC 2280
CCCCGGGCTA CAGCACCCAG TGTGCGTGGA GAAGATGCTG TCAGCGAGGC CAAGTCGCCT 2340
GGCCCCTTCT TCTCCACCAG GAAAGCTAAG AGTCTGGACC TGCATGTCCC CAGCCTGAAG 2400
CAGAGGTCCT CAGGGTCACC AGCTGCCGGG GACCCCGAGA GTAGCCTGTG TGTGGAGTAT 2460
GAGCAGGAGC CAGTTCCTGC CCGGCAGAGG CCCAGGGGGC TGCTGGCCGC CCTGGAGCAC 2520
AGCGAACAGC GGGCGGGGAG CCCTGGCGAG GAGCAGGCCC ACAGCTGCTC CACCCTGTCC 2580
CTCCTGTCTG AGAAGAGGCC GGCAGAAGAA CCGCGAGGAG GGAGGAAGAA GATCCGGCTG 2640
GTCAGCCACC CGGAGGAGCC CGTGGCTGGT GCACAGACGG ACAGGGCCAA GCTCTTCATG 2700
GTGGCCGTGA AGCAGGAGTT GAGCCAAGCC AACTTTGCCA CCTTCACCCA GGCCCTGCAG 2760
GACTACAAGG GTTCCGATGA CTTCGCCGCC CTGGCCGCCT GTCTCGGCCC CCTCTTTGCT 2820
GAGGACCCCA AGAAGCACAA CCTGCTCCAA GGCTTCTACC AGTTTGTGCG GCCCCACCAT 2880
AAGCAGCAGT TTGAGGAGGT CTGTATCCAG CTGACAGGAC GAGGCTGTGG CTATCGGCCT 2940
GAGCACAGCA TTCCCCGAAG GCAGCGGGCA CAGCCGGTCC TGGACCCCAC TGGAAGAACG 3000
GCGCCGGATC CCAAGCTGAC CGTGTCCACG GCTGCAGCCC AGCAGCTGGA CCCCCAAGAG 3060
CACCTGAACC AGGGCAGGCC CCACCTGTCG CCCAGGCCAC CCCCAACAGG AGACCCTGGC 3120
AGCCAACCAC AGTGGGGGTC TGGAGTGCCC AGAGCAGGGA AGCAGGGCCA GCACGCCGTG 3180
AGCGCCTACC TGGCTGATGC CCGCAGGGCC CTGGGGTCCG CGGGCTGTAG CCAACTCTTG 32 0
GCAGCGCTGA CAGCCTATAA GCAAGACGAC GACCTCGACA AGGTGCTGGC TGTGTTGGCC 3300
GCCCTGACCA CTGCAAAGCC AGAGGACTTC CCCCTGCTGC ACAGGTTCAG CATGTTTGTG 3360
CGTCCACACC ACAAGCAGCG CTTCTCACAG ACGTGCACAG ACCTGACCGG CCGGCCCTAC 3420
CCGGGCATGG AGCCACCGGG ACCCCAGGAG GAGAGGCTTG CCGTGCCTCC TGTGCTTACC 3480
CACAGGGCTC CCCAACCAGG CCCCTCACGG TCCGAGAAGA CCGGGAAGAC CCAGAGCAAG 3540
ATCTCGTCCT TCCTTAGACA GAGGCCAGCA GGGACTGTGG GGGCGGGCGG TGAGGATGCA 3600
GGTCCCAGCC AGTCCTCAGG ACCTCCCCAC GGGCCTGCAG CATCTGAGTG GGGTGAGCCT 3660
CATGGGAGAG ACATCGCTGG GCAGCAGGCC ACGGGAGCTC CGGGCGGGCC CCTCTCAGCA 3720
GGCTGTGTGT GCCAGGGCTG TGGGGCAGAG GACGTGGTGC CCTTCCAGTG CCCTGCCTGT 3780 GACTTCCAGC GCTGCCAAGC CTGCTGGCAA CGGCACCTTC AGGCCTCTAG GATGTGCCCA 3840
GCCTGCCACA CCGCCTCCAG GAAGCAGAGC GTCATGCAGG TCTTCTGGCC AGAGCCCCAC 3900
AAGGACCATG AGGGCGCTGG AGGGGCCAGG CCTGTCGCTG CTGTGCCTGG TGTTGGCGCT 3960
GCCTGCCCTG CTGCCGGTGC CGGCTGTACG CGGAGTGGCA GAAACACCCA CCTACCCCTG 4020
GCGGGACGCA GAGACAGGGG AGCGGCTGGT GTGTGCCCAG TGCCCCCCAG GCACCTTTGT 4080
GCAGCGGCCG TGCCGCCGAG ACAGCCCCAC GACGTGTGGC CCGTGTCCAC CGCGCCACTA 4140
CACGCAGTTC TGGAACTACC TGGAGCGCTG CCGCTACTGC AACGTCCTCT GCGGGGAGCG 4200
TGAGGAGGAG GCACGGGCTT GCCACGCCAC CCACAACCGT GCCTGCCGCT GCCGCACCGG 4260
CTTCTTCGCG CACGCTGGTT TCTGCTTGGA GCACGCATCG TGTCCACCTG GTGCCGGCGT 4320
GATTGCCCCG GGCACCCCCA GCCAGAACAC GCAGTGCCAG CCGTGCCCCC CAGGCACCTT 4380
CTCAGCCAGC AGCTCCAGCT CAGAGCAGTG CCAGCCCCAC CGCAACTGCA CGGCCCTGGG 4440
CCTGGCCCTC AATGTGCCAG GCTCTTCCTC CCATGACACC CTGTGCACCA GCTGCACTGG 4500
CTTCCCCCTC AGCACCAGGG TACCAGGAGC TGAGGAGTGT GAGCGTGCCG TCATCGACTT 4560
TGTGGCTTTC CAGGACATCT CCATCAAGAG GCTGCAGCGG CTGCTGCAGG CCCTCGAGGC 4620 CCCGGAGGGC TGGGGTCCGA CACCAAGGGC GGGCCGCGCG GCCTTGCAGC TGAAGCTGCG 4680
TCGGCGGCTC ACGGAGCTCC TGGGGGCGCA GGACGGGGCG CTGCTGGTGC GGCTGCTGCA 4740
GGCGCTGCGC GTGGCCAGGA TGCCCGGGCT GGAGCGGAGC GTCCGTGAGC GCTTCCTCCC 4800
TGTGCACTGA TCCTGGCCCC CTCTTATTTA TTCTACATCC TTGGCACCCC ACTTGCACTG 4860
AAAGAGGCTT TTTTTTAAAT AGAAGAAATG AGGTTTCTTA AAGCTTATTT TTATAAAGCT 4920
TTTTCATAAA ACTGGTTGTA GTTGC 4945
Seq ID NO 36 DNA Sequence Nucleic Acid Accession It N .016434 1 Coding sequence 828 4487 1 11 21 31 41 51
I I I I I I
AGTCAGCCCT GCTGCCAGCC AGTGCCGGGT GCTGGGGACT CAGGGAGGCC CGCCGGGACC 60
ACTGCGGGAC AGTGAGCCGA GCAGAAGCTG GAACGCAGGA GAGGAAGGAG AGGGGGCGGT 120
CAGGGCTCTC AGGAGCCGGG TCCTGGGCAA GGCGCAGCCG TTTTCAAATT TTCAGGAAAG 180 CGGTCGGCTC ACACTCGAGC AGTAAAAAGA TGCCTCTGGG GAGGAGGCCC GTGCAGCTCT 240
CCGGGCAATG GTGGTGGCTC GGCCTAGAGA GGCGGTAGTG GAACGCAGAC CCTGGTGGGG 300
GAATGACATC AAGGGAGGAG ACGGGCGGGA CCCCAGATTT CTGCCTGTGG GCGATGGAAG 360
TGAGGTTCAC TGGCCAGCGG AGCCGGACAC AGAACGCGCA AAACGCCGTG TAGGCCTGGA 420
GGAGCCGAAG AGCAGGCGGA CCCCCTCCGC GGGGGAACAG TTTCCGCCGG GAGCACAAAG 480 CAACGGACCG GAAGTGGGGG GCGGAAGTGC AGTGGGCTCA GCGCCGACTG CGCGCCTCTG 540
CCCGCGAAAA CTCTGAGCTG GCTGACAGCT GGGGACGGGT GGCGGCCCTC GACTGGAGTC 600
GGTTGAGTTC CTGAGGGACC CCGGTTCTGG AAGGTTCGCC GCGGAGACAA GTGAGCAGTC 660
TGTGCCATAG GGATTCTCGA AGAGAACAGC GTTGTGTCCC AGTGCACATG CTCGCATCGC 720
TTACCAGGAG TGCCCGAGAC CCTAAGATGT TCGGAGTGGT TTTTTCGCAC AGACCCGAAT 780 AGCCTGCCCC TCAGCCACGC TCTGTGCCCT TCTGAGAACA GGCTGATATG CCCAAGATAG 840
TCCTG/\ATGG TGTGACCGTA GACTTCCCTT TCCAGCCCTA CAAATGCCAA CAGGAGTACA 900
TGACCAAGGT CCTGGAATGT CTGCAGCAGA AGGTGAATGG CATCCTGGAG AGCCCTACGG 960
GTACAGGGAA GACGCTGTGC CTGCTGTGCA CCACGCTGGC CTGGCGAGAA CACCTCCGAG 1020
ACGGCATCTC TGCCCGCAAG ATTGCCGAGA GGGCGCAAGG AGAGCTTTTC CCGGATCGGG 1080 CCTTGTCATC CTGGGGCAAC GCTGCTGCTG CTGCTGGAGA CCCCATAGCT TGCTACACGG 1140
ACATCCCAAA GATTATTTAC GCCTCCAGGA CCCACTCGCA ACTCACACAG GTCATCAACG 1200
AGCTTCGGAA CACCTCCTAC CGGCCTAAGG TGTGTGTGCT GGGCTCCCGG GAGCAGCTGT 1260
GCATCCATCC TGAGGTGAAG AAACAAGAGA GTAACCATCT ACAGATCCAC TTGTGCCGTA 1320
AGAAGGTGGC AAGTCGCTCC TGTCATTTCT ACAACAACGT AGAAGAAAAA AGCCTGGAGC 1380 AGGAGCTGGC CAGCCCCATC CTGGACATTG AGGACTTGGT CAAGAGCGGA AGCAAGCACA 1440
GGGTGTGCCC TTACTACCTG TCCCGGAACC TGAAGCAGCA AGCCGACATC ATATTCATGC 1500
CGTACAATTA CTTGTTGGAT GCCAAGAGCC GCAGAGCACA CAACATTGAC CTGAAGGGGA 1560
CAGTCGTGAT CTTTGACGAA GCTCACAACG TGGAGAAGAT GTGTGAAGAA TCGGCATCCT 1620
TTGACCTGAC TCCCCATGAC CTGGCTTCAG GACTGGACGT CATAGACCAG GTGCTGGAGG 1680 AGCAGACCAA GGCAGCGCAG CAGGGTGAGC CCCACCCGGA GTTCAGCGCG GACTCCCCCA 1740
GCCCAGGGCT GAACATGGAG CTGGAAGACA TTGCAAAGCT GAAGATGATC CTGCTGCGCC 1800
TGGAGGGGGC CATCGATGCT GTTGAGCTGC CTGGAGACGA CAGCGGTGTC ACCAAGCCAG 1860
GGAGCTACAT CTTTGAGCTG TTTGCTGAAG CCCAGATCAC GTTTCAGACC AAGGGCTGCA 1920
TCCTGGACTC GCTGGACCAG ATCATCCAGC ACCTGGCAGG ACGTGCTGGA GTGTTCACCA 1980 ACACGGCCGG ACTGCAGAAG CTGGCGGACA TTATCCAGAT TGTGTTCAGT GTGGACCCCT 2040
CCGAGGGCAG CCCTGGTTCC CCAGCAGGGC TGGGGGCCTT ACAGTCCTAT AAGGTGCACA 2100
TCCATCCTGA TGCTGGTCAC CGGAGGACGG CTCAGCGGTC TGATGCCTGG AGCACCACTG 2160
CAGCCAGAAA GCGAGGGAAG GTGCTGAGCT ACTGGTGCTT CAGTCCCGGC CACAGCATGC 2220
ACGAGCTGGT CCGCCAGGGC GTCCGCTCCC TCATCCTTAC CAGCGGCACG CTGGCCCCGG 2280 TGTCCTCCTT TGCTCTGGAG ATGCAGATCC CTTTCCCAGT CTGCCTGGAG AACCCACACA 2340
TCATCGACAA GCACCAGATC TGGGTGGGGG TCGTCCCCAG AGGCCCCGAT GGAGCCCAGT 2400
TGAGCTCCGC GTTTGACAGA CGGTTTTCCG AGGAGTGCTT ATCCTCCCTG GGGAAGGCTC 2460
TGGGCAACAT CGCCCGCGTG GTGCCCTATG GGCTCCTGAT CTTCTTCCCT TCCTATCCTG 2520
TCATGGAGAA GAGCCTGGAG TTCTGGCGGG CCCGCGACTT GGCCAGGAAG ATGGAGGCGC 2580 TGAAGCCGCT GTTTGTGGAG CCCAGGAGCA AAGGCAGCTT CTCCGAGACC ATCAGTGCTT 2640 ACTATGCAAG GGTTGCCGCC CCTGGGTCCA CCGGCGCCAC CTTCCTGGCG GTCTGCCGGG 2700 GCAAGGCCAG CGAGGGGCTG GACTTCTCAG ACACGAATGG CCGTGGTGTG ATTGTCACGG 2760 GCCTCCCGTA CCCCCCACGC ATGGACCCCC GGGTTGTCCT CAAGATGCAG TTCCTGGATG 2820 AGATGAAGGG CCAGGGTGGG GCTGGGGGCC AGTTCCTCTC TGGGCAGGAG TGGTACCGGC 2880 AGCAGGCGTC CAGGGCTGTG AACCAGGCCA TCGGGCGAGT GATCCGGCAC CGCCAGGACT 2940 ACGGAGCTGT CTTCCTCTGT GACCACAGGT TCGCCTTTGC CGACGCAAGA GCCCAACTGC 3000 CCTCCTGGGT GCGTCCCCAC GTCAGGGTGT ATGACAACTT TGGCCATGTC ATCCGAGACG 3060 TGGCCCAGTT CTTCCGTGTT GCCGAGCGAA CTATGCCAGC GCCGGCCCCC CGGGCTACAG 3120 CACCCAGTGT GCGTGGAGAA GATGCTGTCA GCGAGGCCAA GTCGCCTGGC CCCTTCTTCT 3180 CCACCAGGAA AGCTAAGAGT CTGGACCTGC ATGTCCCCAG CCTGAAGCAG AGGTCCTCAG 3240 GGTCACCAGC TGCCGGGGAC CCCGAGAGTA GCCTGTGTGT GGAGTATGAG CAGGAGCCAG 3300 TTCCTGCCCG GCAGAGGCCC AGGGGGCTGC TGGCCGCCCT GGAGCACAGC GAACAGCGGG 3360 CGGGGAGCCC TGGCGAGGAG CAGGCCCACA GCTGCTCCAC CCTGTCCCTC CTGTCTGAGA 3420 AGAGGCCGGC AGAAGAACCG CGAGGAGGGA GGAAGAAGAT CCGGCTGGTC AGCCACCCGG 3480 AGGAGCCCGT GGCTGGTGCA CAGACGGACA GGGCCAAGCT CTTCATGGTG GCCGTGAAGC 3540
AGGAGTTGAG CCAAGCCAAC TTTGCCACCT TCACCCAGGC CCTGCAGGAC TACAAGGGTT 3600
CCGATGACTT CGCCGCCCTG GCCGCCTGTC TCGGCCCCCT CTTTGCTGAG GACCCCAAGA 3660
AGCACAACCT GCTCCAAGGC TTCTACCAGT TTGTGCGGCC CCACCATAAG CAGCAGTTTG 3720 AGGAGGTCTG TATCCAGCTG ACAGGACGAG GCTGTGGCTA TCGGCCTGAG CACAGCATTC 3780
CCCGAAGGCA GCGGGCACAG CCGGTCCTGG ACCCCACTGG AAGAACGGCG CCGGATCCCA 3840
AGCTGACCGT GTCCACGGCT GCAGCCCAGC AGCTGGACCC CCAAGAGCAC CTGAACCAGG 3900
GCAGGCCCCA CCTGTCGCCC AGGCCACCCC CAACAGGAGA CCCTGGCAGC CAACCACAGT 3960
GGGGGTCTGG AGTGCCCAGA GCAGGGAAGC AGGGCCAGCA CGCCGTGAGC GCCTACCTGG 4020 CTGATGCCCG CAGGGCCCTG GGGTCCGCGG GCTGTAGCCA ACTCTTGGCA GCGCTGACAG 4080
CCTATAAGCA AGACGACGAC CTCGACAAGG TGCTGGCTGT GTTGGCCGCC CTGACCACTG 140
CAAAGCCAGA GGACTTCCCC CTGCTGCACA GGTTCAGCAT GTTTGTGCGT CCACACCACA 4200
AGCAGCGCTT CTCACAGACG TGCACAGACC TGACCGGCCG GCCCTACCCG GGCATGGAGC 4260
CACCGGGACC CCAGGAGGAG AGGCTTGCCG TGCCTCCTGT GCTTACCCAC AGGGCTCCCC 4320 AACCAGGCCC CTCACGGTCC GAGAAGACCG GGAAGACCCA GAGCAAGATC TCGTCCTTCC 4380
TTAGACAGAG GCCAGCAGGG ACTGTGGGGG CGGGCGGTGA GGATGCAGGT CCCAGCCAGT 4440
CCTCAGGACC TCCCCACGGG CCTGCAGCAT CTGAGTGGGG CCTCTAGGAT GTGCCCAGCC 4500
TGCCACACCG CCTCCAGGAA GCAGAGCGTC ATGCAGGTCT TCTGGCCAGA GCCCCAGTGA 4S60
GTGCCCACGG AGGCCCCCAG CACACCCAAC GTGGCTTGAT CACCTGCCTG TCCAGCTCTG 4620 GTGGGCCAAG AACCCACCCA ACAGAA AGG CCAGCCCATG CCAGCCGGCT TGGCCCGCTG 4680
CAGGCCTCAG GCAGGCGGGG CCCATGGTTG GTCCCTGCGG TGGGACCGGA TCTGGGCCTG 4740
CCTCTGAGAA GCCCTGAGCT ACCTTGGGGT CTGGGGTGGG TTTCTGGGAA AGTGCTTCCC 4800
CAGAACTTCC CTGGCTCCTG GCCTGTGAGT GGTGCCACAG GGGCACCCCA GCTGAGCCCC 4860
TCACCGGGAA GGAGGAGACC CCCGTGGGCA CGTGTCCACT TTTAATCAGG GGACAGGGCT 4920 CTCTAATAAA GCTGCTGGCA GTGCCC 4946
Seq ID NO: 37 DNA Sequence
Nucleic Acid Accession tt- NM_015647.2
Coding sequence- 246..1883
1 11 21 31 41 51
I I I I I I
AGCCTCTCCG GCTACTCGGG GTCAGCGTGG GGCCCCTGCA GCAGATGAGG GTCTTCACTT 60
CGGTGAACTG AACCCTTGAA GCGGCTGTGG GCAGGGCAGC AGGGCTATGG CCACCCCCCA 120
GGTTCGCCTT TGCCGACGCA AGAGCCCAAC TGCCCTCCTG GGTGCGTCCC CACGTCAGGG 180 TGTATGACAA CTTTGGCCAT GTCATCCGAG ACGTGGCCCA GTTCTTCCGT GTTGCCGAGC 240
GAACTATGCC AGCGCCGGCC CCCCGGGCTA CAGCACCCAG TGTGCGTGGA GAAGATGCTG 300
TCAGCGAGGC CAAGTCGCCT GGCCCCTTCT TCTCCACCAG GAAAGCTAAG AGTCTGGACC 360
TGCATGTCCC CAGCCTGAAG CAGAGGTCCT CAGGGTCACC AGCTGCCGGG GACCCCGAGA 420
GTAGCCTGTG TGTGGAGTAT GAGCAGGAGC CAGTTCCTGC CCGGCAGAGG CCCAGGGGGC 480
TGCTGGCCGC CCTGGAGCAC AGCGAACAGC GGGCGGGGAG CCCTGGCGAG GAGCAGGCCC 540
ACAGCTGCTC CACCCTGTCC CTCCTGTCTG AGAAGAGGCC GGCAGAAGAA CCGCGAGGAG 600
GGAGGAAGAA GATCCGGCTG GTCAGCCACC CGGAGGAGCC CGTGGCTGGT GCACAGACGG 660
ACAGGGCCAA GCTCTTCATG GTGGCCGTGA AGCAGGAGTT GAGCCAAGCC AACTTTGCCA 720
CCTTCACCCA GGCCCTGCAG GACTACAAGG GTTCCGATGA CTTCGCCGCC CTGGCCGCCT 780
GTCTCGGCCC CCTCTTTGCT GAGGACCCCA AGAAGCACAA CCTGCTCCAA GGCTTCTACC 840
AGTTTGTGCG GCCCCACCAT AAGCAGCAGT TTGAGGAGGT CTGTATCCAG CTGACGGGAC 900
GAGGCTGTGG CTATCGGCCT GAGCACAGCA TTCCCCGAAG GCAGCGGGCA CAGCCGGTCC 960
TGGACCCCAC TGGAAGAACG GCGCCGGATC CCAAGCTGAC CGTGTCCACG GCTGCAGCCC 1020
AGCAGCTGGA CCCCCAAGAG CACCTGAACC AGGGCAGGCC CCACCTGTCG CCCAGGCCAC 1080
CCCCAACAGG AGACCCTGGC AGCCAACCAC AGTGGGGGTC TGGAGTGCCC AGAGCAGGGA 1140
AGCAGGGCCA GCACGCCGTG AGCGCCTACC TGGCTGATGC CCGCAGGGCC CTGGGGTCCG 1200
CGGGCTGTAG CCAACTCTTG GCAGCGCTGA CAGCCTATAA GCAAGACGAC GACCTCGACA 1260
AGGTGCTGGC TGTGTTGGCC GCCCTGACCA CTGCAAAGCC AGAGGACTTC CCCCTGCTGC 1320
ACAGGTTCAG CATGTTTGTG CGTCCACACC ACAAGCAGCG CTTCTCACAG ACGTGCACAG 1380
ACCTGACCGG CCGGCCCTAC CCGGGCATGG AGCCACCGGG ACCCCAGGAG GAGAGGCTTG 1440
CCGTGCCTCC TGTGCTTACC CACAGGGCTC CCCAACCAGG CCCCTCACGG TCCGAGAAGA 1500
CCGGGAAGAC CCAGAGCAAG ATCTCGTCCT TCCTTAGACA GAGGCCAGCA GGGACTGTGG 1560
GGGCGGGCGG TGAGGATGCA GGTCCCAGCC AGTCCTCAGG ACCTCCCCAC GGGCCTGCAG 1620
CATCTGAGTG GGGTGAGCCT CATGGGAGAG ACATCGCTGG GCAGCAGGCC ACGGGAGCTC 1680
CGGGCGGGCC CCTCTCAGCA GGCTGTGTGT GCCAGGGCTG TGGGGCAGAG GACGTGGTGC 1740
CCTTCCAGTG CCCTGCCTGT GACTTCCAGC GCTGCCAAGC CTGCTGGCAA CGGCACCTTC 1800
AGGCCTCTAG GATGTGCCCA GCCTGCCACA CCGCCTCCAG GAAGCAGAGC GTCATGCAGG 1860
TCTTCTGGCC AGAGCCCCAG TGAGTGCCCA CGGAGGCCCC CAGCACACCC AACGTGGCTT 1920
GATCACCTGC CTGTCCAGCT CTGGTGGGCC AAGAACCCAC CCAACAGAAT AGGCCAGCCC 1980
ATGCCAGCCG GCTTGGCCCG CTGCAGGCCT CAGGCAGGCG GGGCCCATGG TTGGTCCCTG 2040
CGGTGGGACC GGATCTGGGC CTGCCTCTGA GAAGCCCTGA GCTACCTTGG GGTCTGGGGT 2100
GGGTTTCTGG GAAAGTGCTT CCCCAGAACT TCCCTGGCTC CTGGCCTGTG AGTGGTGCCA 2160
CAGGGGCACC CCAGCTGAGC CCCTCACCGG GAAGGAGGAG ACCCCCGTGG GCACGTGTCC 2220
ACTTTTAATC AGGGGACAGG GCTCTCTAAT AAAGCTGCTG GCAGTGCCCA GGAAAAAAAA 2280
AAAAAAAA 2288
Seq ID NO.- 38 DNA Sequence
Nucleic Acid Accession # NM_003823.2
Coding sequence: 101 .1003
1 11 21 31 41 51
I I I I I I
TCCGCAGGCG GACCGGGGGC AAAGGAGGTG GCATGTCGGT CAGGCACAGC AGGGTCCTGT 60
GTCCGCGCTG AGCCGCGCTC TCCCTGCTCC AGCAAGGACC ATGAGGGCGC TGGAGGGGCC 120
AGGCCTGTCG CTGCTGTGCC TGGTGTTGGC GCTGCCTGCC CTGCTGCCGG TGCCGGCTGT 180
ACGCGGAGTG GCAGAAACAC CCACCTACCC CTGGCGGGAC GCAGAGACAG GGGAGCGGCT 240
GGTGTGCGCC CAGTGCCCCC CAGGCACCTT TGTGCAGCGG CCGTGCCGCC GAGACAGCCC 300
CACGACGTGT GGCCCGTGTC CACCGCGCCA CTACACGCAG TTCTGGAACT ACCTGGAGCG 360
CTGCCGCTAC TGCAACGTCC TCTGCGGGGA GCGTGAGGAG GAGGCACGGG CTTGCCACGC 420
CACCCACAAC CGTGCCTGCC GCTGCCGCAC CGGCTTCTTC GCGCACGCTG GTTTCTGCTT 480 GGAGCACGCA TCGTGTCCAC CTGGTGCCGG CGTGATTGCC CCGGGCACCC CCAGCCAGAA 540
CACGCAGTGC CAGCCGTGCC CCCCAGGCAC CTTCTCAGCC AGCAGCTCCA GCTCAGAGCA 600
GTGCCAGCCC CACCGCAACT GCACGGCCCT GGGCCTGGCC CTCAATGTGC CAGGCTCTTC 660
CTCCCATGAC ACCCTGTGCA CCAGCTGCAC TGGCTTCCCC CTCAGCACCA GGGTACCAGG 720 AGCTGAGGAG TGTGAGCGTG CCGTCATCGA CTTTGTGGCT TTCCAGGACA TCTCCATCAA 780
GAGGCTGCAG CGGCTGCTGC AGGCCCTCGA GGCCCCGGAG GGCTGGGGTC CGACACCAAG 840
GGCGGGCCGC GCGGCCTTGC AGCTGAAGCT GCGTCGGCGG CTCACGGAGC TCCTGGGGGC 900
GCAC-GACGGG GCGCTGCTGG TGCGGCTGCT GCAGGCGCTG CGCGTGGCCA GGATGCCCGG 960
GCTGGAGCGG AGCGTCCGTG AGCGCTTCCT CCCTGTGCAC TGATCCTGGC CCCCTCTTAT 1020 TTATTCTACA TCCTTGGCAC CCCACTTGCA CTGAAAGAGG CTTTTTTTTA AATAGAAGAA 1080
ATGAGGTTTC TTAAAGCTTA TTTTTATAAA GCTTTTTCAT AAAA 1124
Seq ID NO 39 DNA Sequence Nucleic Acid Accession # NM_032945 1 Coding sequence 435 1337
1 11 21 31 41 51
I I I I I I
CTGACCACTG CAAAGCCAGA GGACTTCCCC CTGCTGCACA GGTTCAGCAT GTTTGTGCGT 60
CCACACCACA AGCAGCGCTT CTCACAGACG TGCACAGACC TGACCGGCCG GCCCTACCCG 120 GGCATGGAGC CACCGGGACC CCAGGAGGAG AGGCTTGCCG TGCCTCCTGT GCTTACCCAC 180
AGGGCTCCCC AACCAGGCCC CTCACGGTCC GAGAAGACCG GGAAGACCCA GAGCAAGATC 240
TCGTCCTTCC TTAGACAGAG GCCAGCAGGG ACTGTGGGGG CGGGCGGTGA GGATGCAGGT 300
CCCAGCCAGT CCTCAGGACC TCCCCACGGG CCTGCAGCAT CTGAGTGGGG CCTCTAGGAT 360
GTGCCCAGCC TGCCACACCG CCTCCAGGAA GCAGAGCGTC ATGCAGGTCT TCTGGCCGGA 420 GCCCCACAAG GACCATGAGG GCGCTGGAGG GGCCAGGCCT GTCGCTGCTG TGCCTGGTGT 480
TGGCGCTGCC TGCCCTGCTG CCGGTGCCGG CTGTACGCGG AGTGGCAGAA ACACCCACCT 540
ACCCCTGGCG GGACGCAGAG ACAGGGGAGC GGCTGGTGTG CGCCCAGTGC CCCCCAGGCA 600
CCTTTGTGCA GCGGCCGTGC CGCCGAGACA GCCCCACGAC GTGTGGCCCG TGTCCACCGC 660
GCCACTACAC GCAGTTCTGG AACTACCTGG AGCGCTGCCG CTACTGCAAC GTCCTCTGCG 720 GGGAGCGTGA GGAGGAGGCA CGGGCTTGCC ACGCCACCCA CAACCGTGCC TGCCGCTGCC 780
GCACCGGCTT CTTCGCGCAC GCTGGTTTCT GCTTGGAGCA CGCATCGTGT CCACCTGGTG 840
CCGGCGTGAT TGCCCCGGGC ACCCCCAGCC AGAACACGCA GTGCCAGCCG TGCCCCCCAG 900
GCACCTTCTC AGCCAGCAGC TCCAGCTCAG AGCAGTGCCA GCCCCACCGC AACTGCACGG 960
CCCTGGGCCT GGCCCTCAAT GTGCCAGGCT CTTCCTCCCA TGACACCCTG TGCACCAGCT 1020 GCACTGGCTT CCCCCTCAGC ACCAGGGTAC CAGGAGCTGA GGAGTGTGAG CGTGCCGTCA 1080
TCGACTTTGT GGCTTTCCAG GACATCTCCA TCAAGAGGCT GCAGCGGCTG CTGCAGGCCC 1140
TCGAGGCCCC GGAGGGCTGG GGTCCGACAC CAAGGGCGGG CCGCGCGGCC TTGCAGCTGA 1200
AGCTGCGTCG GCGGCTCACG GAGCTCCTGG GGGCGCAGGA CGGGGCGCTG CTGGTGCGGC 1260
TGCTGCAGGC GCTGCGCGTG GCCAGGATGC CCGGGCTGGA GCGGAGCGTC CGTGAGCGCT 1320 TCCTCCCTGT GCACTGATCC TGGCCCCCTC TTATTTATTC TACATCCTTG GCACCCCACT 1380
TGCACTGAAA GAGGCTTTTT TTTAAATAGA AGAAATGAGG TTTCTTAAAA GCTTATTTTT 1440
A AAAGCTTT TTCATAAAA 1459
Seq ID NO 40 DNA Sequence Nucleic Ac id Accession # NM 000593
Coding sequence 165 2591
1 11 21 31 41 SI
I I I I I I
GGCACGAGGG TGTGCGTGAT GGAGAAAATT GGGCACCAGG GCTGCTCCCG AGATTCTCAG 60
ATCTGATTTC CACGCTTGCT ACCAAAATAG TCTGGGCAGG CCACTTTTGG AAGTAGGCGT 120
TATCTAGTGA GCAGGCGGCC GCTTTCGATT TCGCTTTCCC CTAAATGGCT GAGCTTCTCG ISO
CCAGCGCAGG ATCAGCCTGT TCCTGGGACT TTCCGAGAGC CCCGCCCTCG TTCCCTCCCC 240
CAGCCGCCAG TAGGGGAGGA CTCGGCGGTA CCCGGAGCTT CAGGCCCCAC CGGGGCGCGG 300
AGAGTCCCAG ACCCGGCCGG GACCGGGACG GCGTCCGAGT GCCAATGGCT AGCTCTAGGT 360
GTCCCGCTCC CCGCGGGTGC CGCTGCCTCC CCGGAGCTTC TCTCGCATGG CTGGGGACAG 420
TACTGCTACT TCTCGCCGAC TGGGTGCTGC TCCGGACCGC GCTGCCCCGC ATATTCTCCC 480
TGCTGGTGCC CACCGCGCTG CCACTGCTCC GGGTCTGGGC GGTGGGCCTG AGCCGCTGGG 540
CCGTGCTCTG GCTGGGGGCC TGCGGGGTCC TCAGGGCAAC GGTTGGCTCC AAGAGCGAAA 600
ACGCAGGTGC CCAGGGCTGG CTGGCTGCTT TGAAGCCATT AGCTGCGGCA CTGGGCTTGG 660
CCCTGCCGGG ACTTGCCTTG TTCCGAGAGC TGATCTCATG GGGAGCCCCC GGGTCCGCGG 720
ATAGCACCAG GCTACTGCAC TGGGGAAGTC ACCCTACCGC CTTCGTTGTC AGTTATGCAG 780
CGGCACTGCC CGCAGCAGCC CTGTGGCACA AACTCGGGAG CCTCTGGGTG CCCGGCGGTC 840
AGGGCGGCTC TGGAAACCCT GTGCGTCGGC TTCTAGGCTG CCTGGGCTCG GAGACGCGCC 900
GCCTCTCGCT GTTCCTGGTC CTGGTGGTCC TCTCCTCTCT TGGGGAGATG GCCATTCCAT 960
TCTTTACGGG CCGCCTCACT GACTGGATTC TACAAGATGG CTCAGCCGAT ACCTTCACTC 1020
GAAACTTAAC TCTCATGTCC ATTCTCACCA TAGCCAGTGC AGTGCTGGAG TTCGTGGGTG 1080
ACGGGATCTA TAACAACACC ATGGGCCACG TGCACAGCCA CTTGCAGGGA GAGGTGTTTG 1140
GGGCTGTCCT GCGCCAGGAG ACGGAGTTTT TCCAACAGAA CCAGACAGGT AACATCATGT 1200
CTCGGG AAC AGAGGACACG TCCACCCTGA GTGATTCTCT GAGTGAGAAT CTGAGCTTAT 1260
TTCTGTGGTA CCTGGTGCGA GGCCTATGTC TCTTGGGGAT CATGCTCTGG GGATCAGTGT 1320
CCCTCACCAT GGTCACCCTG ATCACCCTGC CTCTGCTTTT CCTTCTGCCC AAGAAGGTGG 1380
GAAAATGGTA CCAGTTGCTG GAAGTGCAGG TGCGGGAATC TCTGGCAAAG TCCAGCCAGG 1440
TGGCCATTGA GGCTCTGTCG GCCATGCCTA CAGTTCGAAG CTTTGCCAAC GAGGAGGGCG 1500
AAGCCCAGAA GTTTAGGGAA AAGCTGCAAG AAATAAAGAC ACTCAACCAG AAGGAGGCTG 1560
TGGCCTATGC AGTCAACTCC TGGACCACTA GTATTTCAGG TATGCTGCTG AAAGTGGGAA 1620
TCCTCTACAT TGGTGGGCAG CTGGTGACCA GTGGGGCTGT AAGCAGTGGG AACCTTGTCA 1680
CATTTGTTCT CTACCAGATG CAGTTCACCC AGGCTGTGGA GGTACTGCTC TCCATCTACC 1740
CCAGAGTACA GAAGGCTGTG GGCTCCTCAG AGAAAATATT TGAGTACCTG GACCGCACCC 1800
CTCGCTGCCC ACCCAGTGGT CTGTTGACTC CCTTACACTT GGAGGGCCTT GTCCAGTTCC 1860
AAGATGTCTC CTTTGCCTAC CCAAACCGCC CAGATGTCTT AGTGCTACAG GGGCTGACAT 1920
TCACCCTACG CCCTGGCGAG GTGACGGCGC TGGTGGGACC CAATGGGTCT GGGAAGAGCA 1980
CAGTGGCTGC CCTGCTGCAG AATCTGTACC AGCCCACCGG GGGACAGCTG CTGTTGGATG 2040
GGAAGCCCCT TCCCCAATAT GAGCACCGCT ACCTGCACAG GCAGGTGGCT GCAGTGGGAC 2100
AAGAGCCACA GGTATTTGGA AGAAGTCTTC AAGAAAATAT TGCCTATGGC CTGACCCAGA 2160 AGCCAACTAT GGAGGAAATC ACAGCTGCTG CAGTAAAGTC TGGGGCCCAT AGTTTCATCT 2220
CTGGACTCCC TCAGGGCTAT GACACAGAGG TAGACGAGGC TGGGAGCCAG CTGTCAGGGG 2280
GTCAGCGACA GGCAGTGGCG TTGGCCCGAG CATTGATCCG GAAACCGTGT GTACTTATCC 2340
TGGATGATGC CACCAGTGCC CTGGATGCAA ACAGCCAGTT ACAGGTGGAG CAGCTCCTGT 2400
ACGAAAGCCC TGAGCGGTAC TCCCGCTCAG TGCTTCTCAT CACCCAGCAC CTCAGCCTGG 2460
TGGAGCAGGC TGACCACATC CTCTTTCTGG AAGGAGGCGC TATCCGGGAG GGGGGAACCC 2520
ACCAGCAGCT CATGGAGAAA AAGGGGTGCT ACTGGGCCAT GGTGCAGGCT CCTGCAGATG 2580
CTCCAGAATG AAAGCCTTCT CAGACCTGCG CACTCCATCT CCCTCCCTTT TCTTCTCTCT 2640
GTGGTGGAGA ACCACAGCTG CAGAGTAGCA GCTGCCTCCA GGATGAGTTA CTTGAAATTT 2700
GCCTTGAGTG TGTTACCTCC TTTCCAAGCT CCTCGTGATA ATGCAGACTT CCTGGAGTAC 2760
AAACACAGGA TTTGTAATTC CTACTGTAAC GGAGTTTAGA GCCAGGGCTG ATGCTTTGGT 2820
GTGGCCAGCA CTCTGAAACT GAGAAATGTT CAGAATGTAC GGAAAGATGA TCAGCTATTT 2880
TCAACATAAC TGAAGGCATA TGCTGGCCCA TAAACACCCT GTAGGTTCTT GATATTTATA 2940
ATAAAATTGG TGTTTTGT 2958
Seq ID NO: 41 DNA Sequence
Nucleic Acid Accession β • NM.002423 2
Coding sequence. 48..851
1 11 21 31 41 51 I I I I I I
ACCAAATCAA CCATAGGTCC AAGAACAATT GTCTCTGGAC GGCAGCTATG CGACTCACCG 60
TGCTGTGTGC TGTGTGCCTG CTGCCTGGCA GCCTGGCCCT GCCGCTGCCT CAGGAGGCGG 120
GAGGCATGAG TGAGCTACAG TGGGAACAGG CTCAGGACTA TCTCAAGAGA TTTTATCTCT 180
ATGACTCAGA AACAAAAAAT GCCAACAGTT TAGAAGCCAA ACTCAAGGAG ATGCAAAAAT 240 TCTTTGGCCT ACCTATAACT GGAATGTTAA ACTCCCGCGT CATAGAAATA ATGCAGAAGC 300
CCAGATGTGG AGTGCCAGAT GTTGCAGAAT ACTCACTATT TCCAAATAGC CCAAAATGGA 360
CTTCCAAAGT GGTCACCTAC AGGATCGTAT CATATACTCG AGACTTACCG CATATTACAG 420
TGGATCGATT AGTGTCAAAG GCTTTAAACA TGTGGGGCAA AGAGATCCCC CTGCATTTCA 480
GGAAAGTTGT ATGGGGAACT GCTGACATCA TGATTGGCTT TGCGCGAGGA GCTCATGGGG 540 ACTCCTACCC ATTTGATGGG CCAGGAAACA CGCTGGCTCA TGCCTTTGCG CCTGGGACAG 600
GTCTCGGAGG AGATGCTCAC TTCGATGAGG ATGAACGCTG GACGGATGGT AGCAGTCTAG 660
GGATTAACTT CCTGTATGCT GCAACTCATG AACTTGGCCA TTCTTTGGGT ATGGGACATT 720
CCTCTGATCC TAATGCAGTG ATGTATCCAA CCTATGGAAA TGGAGATCCC CAAAATTT A 780
AACTTTCCCA GGATGATATT AAAGGCATTC AGAAACTATA TGGAAAGAGA AGTAATTCAA 840 GAAAGAAATA GAAACTTCAG GCAGAACATC CATTCATTCA TTCATTGGAT TGTATATCAT 900
TGTTGCACAA TCAGAATTGA TAAGCACTGT TCCTCCACTC CATTTAGCAA TTATGTCACC 960
CTTTTTTATT GCAGTTGGTT TTTGAATGTC TTTCACTCCT TTTATTGGTT AAACTCCTTT 1020
ATGGTGTGAC TGTGTCTTAT TCCATCTATG AGCTTTGTCA GTGCGCGTAG ATGTCAATAA 1080
ATGTTACATA CACAAATAAA TAAAATGTTT ATTCCATGGT AAATTTA 1127
Seq ID NO. 42 DNA Sequence
Nucleic Acid Accession tl : NM.018674
Coding sequence- 390 .2009
1 11 21 31 41 51 i i i i i i
CGGAGCACAT GCTGAGCGGA GCGGCTGGGG CTGCGCGGCG TGGCGGAGCA GCGCTCGCTC 60
CCTCGCTCAC TCGCTCGCTC GCAGGGACAC ACGCAGGGGC TGACAGCTGT GCTGGTGCTG 120
ATAAGGGAAG CCACAAGGAG ACGATCGAGG AGAGAGACAA GCGGCAGCAG AGGCAGCAGC 180
GGCAGAGGCA GCACCAGGGC TGCGGAGCTG CTGGGAGTGG GAGTGACTCC CCCACCTCGG 240
GCCCCCACCC TGTCCCTGTC CTCTTCCCGC TTGCCCTGAG TTTAGAAGAG CAGCCGCTGC 300
CACCACTGCC ACTCGGGAGG GCACCAGGGC TGCTGGCTAG GGAGGGACAG GGCAGGGAGG 360
CTCTGGCCAG TCCCAGCAGC CGGGGACAGA TGCCGATCGA GATTGTGTGC AAAATCAAAT 420
TTGCTGAGGA GGATGCGAAA CCCAAGGAGA AGGAGGCAGG GGATGAGCAG AGCCTCCTCG 480
GGGCTGTTGC CCCTGGAGCA GCCCCCCGAG ACCTGGCCAC CTTTGCCAGC ACCAGCACCC 540
TGCATGGACT GGGCCGGGCC TGTGGCCCAG GCCCCCACGG ACTGCGCAGA ACCCTGTGGG 600
CACTGGCCCT ACTCACCTCG CTGGCTGCCT TCCTGTACCA GGCGGCTGGC CTGGCCCGGG 660
GCTACCTGAC CCGGCCTCAC CTGGTGGCAA TGGACCCCGC TGCCCCAGCC CCAGTGGCGG 720
GCTTCCCGGC TGTCACCCTC TGCAATATCA ACCGCTTCCG GCATTCGGCA CTCAGCGATG 780
CCGACATCTT CCACCTGGCC AATCTGACAG GGCTGCCCCC CAAAGACCGG GATGGGCACC 840
GTGCGGCTGG CCTGCGCTAC CCAGAGCCTG ACATGGTAGA CATCCTCAAC CGCACTGGCC 900
ACCAGCTCGC CGACATGCTT AAGAGCTGCA ACTTCAGTGG GCATCACTGC TCCGCCAGCA 960
ACTTCTCTGT GGTCTATACT CGCTATGGGA AGTGTTACAC CTTCAACGCG GACCCGCGGA 1020
GCTCGCTGCC CAGCCGGGCA GGGGGCATGG GCAGTGGCCT GGAGATCATG CTGGACATCC 1080
AGCAGGAGGA GTACCTGCCC ATCTGGAGGG AGACAAATGA GACGTCGTTT GAGGCAGGTA 1140
TTCGGGTGCA GATCCACAGC CAGGAGGAGC CGCCCTACAT CCACCAGCTG GGGTTCGGGG 1200
TGTCCCCAGG CTTCCAGACC TTTGTGTCCT GCCAGGAACA GCGGCTGACC TACCTGCCCC 1260
AGCCCTGGGG CAACTGCCGC GCAGAGAGTG AGCTCAGGGA GCCTGAGCTT CAGGGCTACT 1320
CGGCCTACAG TGTGTCTGCC TGCCGGCTGC GCTGTGAAAA GGAGGCCGTG CTTCAGCGCT 1380 GCCACTGCCG GATGGTGCAC ATGCCAGGCA ATGAGACCAT CTGCCCACCA AATATCTACA 1440 TCGAGTGTGC AGACCACACA CTGGACTCCC TGGGTGGGGG CCCTGAGGGC CCGTGCTTCT 1500 GCCCCACCCC CTGCAACCTG ACACGCTATG GGAAAGAGAT CTCCATGGTC AGGATCCCCA 1560 ACAGGGGCTC AGCCCGGTAC CTGGCGAGGA AGTACAACCG CAACGAGACC TACATACGGG 1620 AGAACTTCCT GGTCCTAGAT GTCTTCTTTG AGGCCCTGAC CTCTGAAGCC ATGGAGCAGC 1680 GAGCAGCCTA TGGCCTGTCA GCCCTGCTGG GAGACCTCGG GGGACAGATG GGCCTGTTCA 1740 TTGGGGCCAG CATCCTCACG TTGCTGGAGA TCCTCGACTA CATCTATGAG GTGTCCTGGG 1800 ATCGACTGAA GCGGGTATGG AGGCGTCCCA AGACCCCCCT GCGGACCTCC ACTGGGGGCA 1860 TCTCCACTTT GGGGCTTCAG GAGCTGAAGG AACAGAGTCC CTGCCCGAGC CTGGGCCGAG 1920 CGGAGGGTGG GGGGGTCAGC AGTCTGCTCC CCAATCACCA CCACCCCCAC GGTCCCCCAG 1980 GAGGTCTCTT TGAAGATTTT GCTTGCTAGG ACGGTGCTGT GACTGAAAGG ACCCAGGAGT 2040 CTGGGACCCC TCCTGGGATC CCCAGCACAT TCTCCTGCTC CTGGGAGAGG CCTGGGGGCG 2100 GTGCTCACTG GGAGGGCCAG GACTCAGTTC CTGCTCTCAT CCTCCCCTGC CCTGATGTCA 2160 GCTGCTTTGC ACAAAGGTCC TTCTTGTCCA CACCCCTTAT CCCCAGGCTG GTGCCCCGGG 2220 AGGGCTGGAG ACCAGGCCAT GGGCCCTCAC GGAGAGGAAG GGAAGGAAGG AGAGGGAGGG 2280 GGAGGATAGA GCCCATCCCA GCCGGGGAGG GGGAGCCCTC TGTACATTTG TAAATATTTA 2340 GGGAAAGCCG GGTGGGGGGA GGGGATACAG ATGTAGAAGG TGGGTAGGGC TACAGGGGTG 2400
GGTGATTTAG GGACAGCCAG GGTCCCAGCC CCAATGTCAG CAGGATAGGG AGAGCCCCAG 2460
GACTCAGGAG TGCTGGGCTG GTCCTACTTC CTGCCCCTCT CCAGGCCCAG CTCCCCTCTT 2520
GGCAGGGGGA GAGGATGGCC CAGCAGGCCT GGCCCAGCTC CCAGTTCCCC CTGCACCAGC 2580
CCCACCCCTA GAGTCCCTTC TATAGGGAGG GGGCAGGAGA CCTTCCAGAC TTCGGCTGAG 2640
CTTGGAGGGT GGGAAGGGAG CCTTCTCAGT CCTCTCTCCC TCCAGTCTGA TTTTATAAAG 2700
TGCTGACGAG 2710
Seq ID NO: 43 DNA Sequence
Nucleic Acid Accession # -. AK091016
Coding sequence: 201..2291
1 11 21 31 41 51
I I I I I I
GATCTCAGCT CCTTTTCAGC TAGTGGGTGG AACCCCAGGA GGGAAAACTC AGGGAAGCCC 60
AGGAGGAAGT GAAAATACCC CATGGAGTGA AGCTTGTGTG CTACCTGGGT TCCGGGCCAG 120
TGATCCAGCT CCTGGGGGGC ATCAGCCACG GCCAGGCAGG GGGGCAGCTG CCACCAAAGC 180
TGGAGGTTCT AGAGGACTTG ATGGAGGTCA GCTCACCCTC ACCTGCCCAG AGGCTCAGAA 240
GGAAGAAAAG GCCCATGGTG CAGGGCCCTG CTGGGTGCCA GGTTTTCCAG CCTTCTCCTT 300
CAGGAGGCAC AGCAGGGGAC CCTGGTGGCC TCTCTGACCC CTTCTACCCT CCAAGAAGCG 360
GTTCCCTGGC CCTTGGCGAC CCCAGCTCGG ACCCTGCATG TTCCCAGAGT GGCCCAATGG 420
AGGCTGAAGA GGATTCTCTT CCGGAGCAGC CAGAGGACTC AGCTCAGCTC CAACAGGAGA 480
AGCCATCCCT GTATATTGGG GTGCGGGGCA CTGTTGTCCG TTCCATGCAG GAGGTACTAT 540
GGACTCGCCT TCGGGAGCTC CCAGACCCAG TGCTGAGTGA GGAGGTGGTG GAGGGCATTG 600
CTGCTGGCAT TGAGGCAGCC CTCTGGGACC TGACACAAGG CACCAATGGC CGGTACAAGA 660
CCAAGTATCG CAGCCTGCTG TTCAACCTGC GGGACCCCAG GAACCTGGAC TTGTTTCTCA 720
AAGTGGTTCA TGGAGATGTC ACCCCCTACG ACCTGGTGCG GATGAGCTCG ATGCAGCTGG 780
CCCCCCAGGA GCTGGCCCGC TGGCGGGACC AGGAGGAGAA AAGGGGCCTG AATATCATTG 840
AGCAGCAACA GAAGGAGCCG TGCAGACTTC CAGCCTCCAA AATGACCCAC AAGGGCGAAG 900
TGGAGATTCA GCGGGACATG GACCAGACAC TGACCCTGGA GGATCTGGTG GGACCGCAGA 960
TGTTCATGGA CTGCAGCCCA CAGGCCCTGC CCATCGCATC AGAGGACACC ACGGGGCAGC 1020
ATGACCACCA CTTCTTAGAC CCCAACTGCC ACATCTGCAA GGACTGGGAG CCCTCGAATG 1080
AGCTGCTAGG CTCCTTCGAA GCCGCCAAGA GCTGCGGGGA CAATATCTTC CAGAAAGCCC 1140
TAAGCCAAAC TCCTATGCCT GCTCCAGAGA TGCCCAAAAC CAGGGAGTTG TCTCCCACGG 1200
AACCACAGGA CAGGGTCCCT CCATCTGGGC TCCATGTGCC TGCTGCACCC ACAAAGGCCC 1260
TGCCCTGCCT GCCACCCTGG GAAGGTGTTC TGGACATGTT CTCCATCAAG CGGTTCCGGG 1320
CCAGGGCCCA GCTGGTCTCG GGACACAGCT GTCGGCTTGT CCAGGCTCTG CCCACCGTGA 1380
TCCGCTCGGC AGGCTGCATC CCCTCCAACA TTGTCTGGGA CCTTCTGGCC AGCATCTGCC 1440
CAGCCAAGGC CAAGGACGTC TGCGTGGTCA GACTGTGCCC ACATGGGGCC CGGGACACCC 1500
AGAACTGCCG CCTGCTCTAC TCATACCTCA ATGATAGGCA GCGCCACGGG CTGGCCTCTG 1560
TGGAGCACAT GGGGATGGTC CTGCTGCCCC TGCCTGCCTT CCAGCCCCTG CCCACCAGGC 1620
TGCGCCCTTT GGGGGGCCCA GGTCTGGAGG TCACTCACTC AAGTCTGTTG CTGGCTGTGC 1680
TGCTCCCCAA GGAAGGGCTT CCAGACACAG CAGGGTCCAG CCCCTGGTTG GGGAAGGTTC 1740
AAAAGATGGT CTCCTTCAAC AGTAAGGTGG AGAAGAGATA CTATCAGCCA GATGACAGGA 1800
GGCCGAATGT GCCCCTGAAG GGCACCCCTC CCCCAGGAGG TGCCTGGCAG CAGAGCCAGG 1860
GCAGGGGCAG TATAGCTCCA AGGGGAATCT CTGCTTGGCA GAGGCCCCCC AGAGGCAGGG 1920
GGAGGCTCTG GCCAGAGCCT GAAAACTGGC AGCATCCTGG GCGAGGGCAG TGGCCCCCAG 1980
AGCCAGGCTT GCGCCAGTCC CAGCATCCCT ATTCAGTAGC ACCAGCTGGT CATGGCTTTG 2040
GCCGTGGCCA GCACTTCCAC AGGGACTCCT GTCCCCACCA AGCCCTGCTC CGGCACCTCG 2100
AATCCCTGGC GACCATGAGT CACCAGCTCC AAGCCTTACT GTGCCCCCAG ACCAAGAGCT 2160
CCATCCCCCG CCCTCTGCAG CGTTTGTCTA GCGCCCTTGC AGCTCCAGAG CCCCCTGGCC 2220
CAGCCCGTGA CTCCTCTTTG GGGCCTACAG ATGAAGCTGG CTCTGAGTGT CCCTTCCCTA 2280
GAAAGGCCTG ACCCTCCTTA CCCACCAGAA CAGGGGTTTT GATGCCCTCA CTAGTGTTGA 2340
AGCCTGTTCC AGAGAGAGGT GGGACTGCAA GGAGAGGATG GTCAGCCCTA CCCACCTGCC 2400
CTGTTTGAAC TTCCTGTTTG ACAATGTTTG CTGTTGATTT TTTGTTCAAT AAAGAATTTG 2 60
GT 2462
Seq ID NO: 44 DNA Sequence
Nucleic Acid Accession tt : NM.005291
Coding sequence: 75..1178
1 11 21 31 41 51
I I I I I I
CCGACACCCA CGGGCGGAGA TCACCTGCTG CCCCGCAGAC CCCTGTCCCT TCCTCCCGGA 60
CCAGCAGCTA GAGGATGTCC AAACGGAGTT GGTGGGCTGG ATCCAGAAAG CCCCCAAGAG 120
AGATGCTGAA ACTCTCAGGC TCTGACTCCA GCCAAAGCAT GAATGGCCTT GAAGTGGCTC 180
CCCCAGGTCT GATCACCAAC TTCTCCCTGG CCACGGCAGA GCAATGTGGC CAGGAGACGC 240 CACTGGAGAA CATGCTGTTC GCCTCCTTCT ACCTTCTGGA TTTTATCCTG GCTTTAGTTG 300 GCAATACCCT GGCTCTGTGG CTTTTCATCC GAGACCACAA GTCCGGGACC CCGGCCAACG 360
TGTTCCTGAT GCATCTGGCC GTGGCCGACT TGTCGTGCGT GCTGGTCCTG CCCACCCGCC 420
TGGTCTACCA CTTCTCTGGG AACCACTGGC CATTTGGGGA AATCGCATGC CGTCTCACCG 480 GCTTCCTCTT CTACCTCAAC ATGTACGCCA GCATCTACTT CCTCACCTGC ATCAGCGCCG 540 ACCGTTTCCT GGCCATTGTG CACCCGGTCA AGTCCCTCAA GCTCCGCAGG CCCCTCTACG 600 CACACCTGGC CTGTGCCTTC CTGTGGGTGG TGGTGGCTGT GGCCATGGCC CCGCTGCTGG 660 TGAGCCCACA GACCGTGCAG ACCAACCACA CGGTGGTCTG CCTGCAGCTG TACCGGGAGA 720 AGGCCTCCCA CCATGCCCTG GTGTCCCTGG CAGTGGCCTT CACCTTCCCG TTCATCACCA 780 CGGTCACCTG CTACCTGCTG ATCATCCGCA GCCTGCGGCA GGGCCTGCGT GTGGAGAAGC 840 GCCTCAAGAC CAAGGCAGTG CGCATGATCG CCATAGTGCT GGCCATCTTC CTGGTCTGCT 900 TCGTGCCCTA CCACGTCAAC CGCTCCGTCT ACGTGCTGCA CTACCGCAGC CATGGGGCCT 960 CCTGCGCCAC CCAGCGCATC CTGGCCCTGG CAAACCGCAT CACCTCCTGC CTCACCAGCC 1020 TCAACGGGGC ACTCGACCCC ATCATGTATT TCTTCGTGGC TGAGAAGTTC CGCCACGCCC 1080 TGTGCAACTT GCTCTGTGGC AAAAGGCTCA AGGGCCCGCC CCCCAGCTTC GAAGGGAAAA 1140 CCAACGAGAG CTCGCTGAGT GCCAAGTCAG AGCTGTGAGC GGGGGGCGCC GTCCAGGCCG 1200 AGCGCAGACT GTTTAGGACT CAGCAGACCC AGCAAGAGGC ATCTGCCCTT TCCCCAGCCA 1260 CCTCCCCAGC AAGCAACCTG AAATCTCAGC AGATGCCCAC CATTTCTCTA GATCGCCTAG 1320 TCTCAACCCA TAAAAAGGAA GAACTGACAA AGGGGATCCA TCGGCCACCC CTCTGCAGGG 1380 GCTTGTGATG GCTACAATGG CTCCTAGACA CTCAACGACT TCATCTGTGG CAGGGAGAGA 1440
GGAGGCCGGA AGAACAACCC CTGAACAATG GAGGCCTTTC TTTCCCGCTA GGCTCCCAGC 1500
CTCCTTCCCG CTACAGAATC GCTCATCGGC GAGGCTCAGC AGAAAGACCC TGAAGGCAGG 1560
CTGCAAATGA CCCAGAAGAG GGACCTGGGA GTCCTGGTGG GGACGGGGAG GGAGTCTCAA 1620
TACTCCTTTG CAGCGCAAGG TACTCTGAGT CCCCTCTGTA GTGCCTCTGC CAGACACACA 1680
CTGCCTGAGT TGAAGAGACA CAGGCCACAC ATTTCAGGCT GGTTGCCAGC GGACGTCAGC 1740
ACTCACGGCC TGCGGGGACT CAGCACAGCT CTGGATTCTG GATCTCTCCT GCTGTAACCC 1800
CACGCACAAG CCTGCAACCC CCAGAGCTCT TTGACAGGCT CCCAGGCCTC CCAGTCCTGG 1860
ACAAGCATGT GCAGTCACGG GAGCTCAGCT CAGGCCAGGG CTGGGCTGTG CACCTGCCTC 1920
CCACTGACCC AGACCCACTT CCTCCAGAGA GGCCTCTCTC CGCCTGAGCT ATTTCCCTTG 1980
CTAGTGTGCA GATATTTCCC TAACATGTCC TTTTTTGTAT TTGTTTGTAC GGACCATAAA 2040
TATAACTGTA GCTTTAAGAC TAAAAAAAAA 2070
Seq ID NO 45 DNA Sequence
Nucleic Acid Accession tt NM_018643
Coding sequence 48 752
1 11 21 31 41 51
I I I I I I
CTACTACTAC TAAATTCGCG GCCGGTCGAC GCTGGTGCAC AGGAAGGATG AGGAAGACCA 60
GGCTCTGGGG GCTGCTGTGG ATGCTCTTTG TCTCAGAACT CCGAGCTGCA AC AAATTAA 120
CTGAGGAAAA GTATGAACTG AAAGAGGGGC AGACCCTGGA TGTGAAATGT GACTACACGC 180
TAGAGAAGTT TGCCAGCAGC CAGAAAGCTT GGCAGATAAT AAGGGACGGA GAGATGCCCA 240
AGACCCTGGC ATGCACAGAG AGGCCTTCAA AGAATTCCCA TCCAGTCCAA GTGGGGAGGA 300
TCATACTAGA AGACTACCAT GATCATGGTT TACTGCGCGT CCGAATGGTC AACCTTCAAG 360
TGGAAGATTC TGGACTGTAT CAGTGTGTGA TCTACCAGCC TCCCAAGGAG CCTCACATGC 420
TGTTCGATCG CATCCGCTTG GTGGTGACCA AGGGTTTTTC AGGGACCCCT GGCTCCAATG 480
AGAATTCTAC CCAGAATGTG TATAAGATTC CTCCTACCAC CACTAAGGCC TTGTGCCCAC 540
TCTATACCAG CCCCAGAACT GTGACCCAAG CTCCACCCAA GTCAACTGCC GATGTCTCCA 600
CTCCTGACTC TGAAATCAAC CTTACAAATG TGACAGATAT CATCAGGGTT CCGGTGTTCA 660
ACATTGTCAT TCTCCTGGCT GGTGGATTCC TGAGTAAGAG CCTGGTCTTC TCTGTCCTGT 720
TTGCTGTCAC GCTGAGGTCA TTTGTACCCT AGGCCCACGA ACCCACGAGA ATGTCCTCTG 780
ACTTCCAGCC ACATCCATCT GGCAGTTGTG CCAAGGGAGG AGGGAGGAGG TAAAAGGCAG 840
GGAGTTAATA ACATGAATTA AATCTGTAAT CACCAGCTAT TTCT 884
Seq ID NO 46 DNA Sequence
Nucleic Acid Accession tl NM_003467
Coding sequence 1 1059
1 11 21 31 41 51
I I I I I I
ATGGAGGGGA TCAGTATATA CACTTCAGAT AACTACACCG AGGAAATGGG CTCAGGGGAT 60
TATGACTCCA TGAAGGAACC CTGTTTCCGT GAAGAAAATG CTAATTTCAA TAAAATCTTC 120
CTGCCCACCA TCTACTCCAT CATCTTCTTA ACTGGCATTG TGGGCAATGG ATTGGTCATC 180
CTGGTCATGG GTTACCAGAA GAAACTGAGA AGCATGACGG ACAAGTACAG GCTGCACCTG 240
TCAGTGGCCG ACCTCCTCTT TGTCATCACG CTTCCCTTCT GGGCAGTTGA TGCCGTGGCA 300
AACTGGTACT TTGGGAACTT CCTATGCAAG GCAGTCCATG TCATCTACAC AGTCAACCTC 360
TACAGCAGTG TCCTCATCCT GGCCTTCATC AGTCTGGACC GCTACCTGGC CATCGTCCAC 420
GCCACCAACA GTCAGAGGCC AAGGAAGCTG TTGGCTGAAA AGGTGGTCTA TGTTGGCGTC 480
TGGATCCCTG CCCTCCTGCT GACTATTCCC GACTTCATCT TTGCCAACGT CAGTGAGGCA 540
GATGACAGAT ATATCTGTGA CCGCTTCTAC CCCAATGACT TGTGGGTGGT TGTGTTCCAG 600
TTTCAGCACA TCATGGTTGG CCTTATCCTG CCTGGTATTG TCATCCTGTC CTGCTATTGC 660
ATTATCATCT CCAAGCTGTC ACACTCCAAG GGCCACCAGA AGCGCAAGGC CCTCAAGACC 720
ACAGTCATCC TCATCCTGGC TTTCTTCGCC TGTTGGCTGC CTTACTACAT TGGGATCAGC 780
ATCGACTCCT TCATCCTCCT GGAAATCATC AAGCAAGGGT GTGAGTTTGA GAACACTGTG 840
CACAAGTGGA TTTCCATCAC CGAGGCCCTA GCTTTCTTCC ACTGTTGTCT GAACCCCATC 900
CTCTATGCTT TCCTTGGAGC CAAATTTAAA ACCTCTGCCC AGCACGCACT CACCTCTGTG 960
AGCAGAGGGT CCAGCCTCAA GATCCTCTCC AAAGGAAAGC GAGGTGGACA TTCATCTGTT 1020
TCCACTGAGT CTGAGTCTTC AAGTTTTCAC TCCAGCTAA 1059
Seq ID NO 47 DNA Sequence
Nucleic Acid Accession tt Eos sequence
1 11 21 31 41 51
I I I I I I
GTGTGTAGTC GGGTATGAGA ACGATTGCAA GCAAAAGCAG CTGAGGGACG CTGTCCAAGG 60
AGTAGGCTCA GTAGCACGAA CTGCAAATAC TTGAGAAGGG AAAAGTTCAG CCTTGTGCTG 120
GAAAGTGGTT TAGCATGCTG GAGCTGGTTT TCTGCTTGGT AGCCCTACAA CTTTGGCCCA 180
ACTACTTGGC CTCTGGGACT CAGATTCCTC CTCTTTAAAA TGGTGCTAAT AATAGCACCC 240
ACCCTCTGTG AGGAGGATGC TGTGAGGACA AAATGAGATC ATCCACATAA GCCGTGAACC 300
CTGTTCCTGG TAAGCTCCTG GAAAGAAGTC TATGGATTAT ACTCAACCTA CACTCCAGTT 360
AAAGGAACAT CTACACACAG AGGAAATGAA TAACATGAAG TGAAGTCTTC ATCTCCATTC 420
CCAACAGTCC CCATTCTACT TGCAGAAAGG TTGCTTACAC TGAAAATCAG TTTATTTTCC 480 CCTGGTGCAA AGAACAGTCG TTTCTCCAAA ACTGAAGCTG GAAATTATCT GAAATATCAG 540 GTCCTCCGGA AAAGGGACGT GAAGCCCCCT TTGTAATTTC TGCATTAGCG TGCTCTCCTG 600 GCAAGCAGGA AACCTCATCA GAGAAGTCAG CCAAGGAAAG TCTTTAAATG GAAATTGTGC 660 AAACGAGGAG CAAATGCATT AAAAAGTTGC TGACGGGCAT GAAATGCTTT GATGTGAAGA 720 CGGAAAACTC CAAGCAGGAA GGATTTTAAC ATTTTGAATC TGATTGACTC TGTGGTTTCT 780 CAGCACAGTT ATTCCATGGG CTAAAATAAA TGCAGAAATG GTACTTTCAG ACCACAGCTG 840 CAGAGGGGAT CGTGGTGAAT TTCAATGAAA ATCCATTTGA ATCTTGAGGT TCAGATCTTA 900 AAAAAGCAAA GGACATGAGA GAAGTAATAT TGTTGCTTGA AATTTCATTG CTTATATCTA 960 AAAGAAACTC CTATTTTTAA GAGAAATGTT GAATCTTTGC AACGTGGTAG ACGCTCCCAC 1020 AAAACTTTCT CCTGAAATAG GAGATAAATG TTGGAAAGAG GCAATGTATT GAGTATGCTG 1080 ATAGAGGTGG AGTTCAGAGA CAGGCAAGCA TACATAAGAG TCAGGATGTT TTTCAGTATT 1140 ATCTTTACAA ATGAGTTTCT TACAGTGGTC AATGACAAAC CAATTTCATT CAAAGCTTGC 1200 TTCAATAGGC AATGGTTTGA TGCCAATATG TTAGCTATTT ACTTTGACCA CCGTATGCAT 1260 TAAAAAGAAG AAAAATTAAG AATACTCAAG CAGAACCTCC AACTTAGATA GCACTTTCCA 1320 CAAAAAGTAA TGGAGGGATA GACTGAAGTT AAATGGGATC AGGTATGTGA TGAGATCTCA 1380
GAAGTGTTTG CACAATAATG CAGATACTCA TTTTAAACAG AGTCATAAGG ATTGGAACTA 1440
ATAAAAATAA TAGAATAAAA TACCGATCAA GAATGTGTCC TCCTGCGTAT CTGGGTTTTG 1500
AATTCTGGCT CCACAGAACT TGTCAGATAT ATGACATTAA AC 1542
Seq ID NO 48 DNA Sequence Nucleic Acid Accession # Eos sequence Coding sequence 52 1131 - - 1 11 21 31 41 51
10 i i i i i i
ATGCATCCTC AAGTGGTCAT CTTAAGCCTC ATCCTACATC TGGCAGATTC TGTAGCTGGT 60
TCTGTAAAGG TTGGTGGAGA GGCAGGTCCA TCTGTCACAC TACCCTGCCA CTACAGTGGA 120
GCTGTCACAT CAATGTGCTG GAATAGAGGC TCATGTTCTC TATTCACATG CCAAAATGGC 180
ATTGTCTGGA CCAATGGAAC CCACGTCACC TATCGGAAGG ACACACGCTA TAAGCTATTG 240
15 GGGGACCTTT CAAGAAGGGA TGTCTCTTTG ACCATAGAAA A ACAGCTGT GTCTGACAGT 300
GGCGTATATT GTTGCCGTGT TGAGCACCGT GGGTGGTTCA ATGACATGAA AATCACCGTA 360
TCATTGGAGA TTGTGCCACC CAAGGTCACG ACTACTCCAA TTGTCACAAC TGTTCCAACC 420
GTCACGACTG TTCGAACGAG CACCACTGTT CCAACGACAA CGACTGTTCC AACGACAACT 480
GTTCCAACAA CAATGAGCAT TCCAACGACA ACGACTGTTC CGACGACAAT GACTGTTTCA 540 0 ACGACAACGA GCGTTCCAAC GACAACGAGC ATTCCAACAA CAACAAGTGT TCCAGTGACA 600
ACAACGGTCT CTACCTTTGT TCCTCCAATG CCTTTGCCCA GGCAGAACCA TGAACCAGTA 660
GCCACTTCAC CATCTTCACC TCAGCCAGCA GAAACCCACC CTACGACACT GCAGGGAGCA 720
ATAAGGAGAG AACCCACCAG CTCACCATTG TACTCTTACA CAACAGATGG GAATGACACC 780
GTGACAGAGT CTTCAGATGG CCTTTGGAAT AACAATCAAA CTCAACTGTT CCTAGAACAT 840
25 AGTCTACTGA CGGCCAATAC CACTAAAGGA ATCTATGCTG GAGTCTGTAT TTCTGTCTTG 900
GTGCTTCTTG CTCTTTTGGG TGTCATCATT GCCAAAAAGT ATTTCTTCAA AAAGGAGGTT 960
CAACAACTAA GTGTTTCATT TAGCAGCCTT CAAATTAAAG CTTTGCAAAA TGCAGTTGAA 1020
AAGGAAGTCC AAGCAGAAGA CAATATCTAC ATTGAGAATA GTCTTTATGC CACGGACTAA 1080
30 Seq ID NO 49 DNA Sequence
Nucleic Acid Accession tt NM_004932 2
Coding sequence 327 2699
1 11 21 31 41 51
I I I I I I
35 ACTTCATTCA CTTGCAAATC AGTGTGTGCC CACAAGAGCC AGCTCTCCCG AGCCCGTAAC 60
CTTCGCATCC CAAGAGCTGC AGTTTCAGCC GCGACAGCAA GAACGGCAGA GCCGGCGACC 120
GCGGCGGCGG CGGCGGCGGA GGCAGGAGCA GCCTGGGCGG GTCGCAGGGT CTCCGCGGGC 180
GCAGGAAGGC GAGCAGAGAT ATCCTCTGAG AGCCAAGCAA AGAACATTAA GGAAGGAAGG 240
AGGAATGAGG CTGGATACGG TGCAGTGAAA AAGGCACTTC CAAGAGTGGG GCACTCACTA 300
40 CGCACAGACT CGACGGTGCC ATCAGCATGA GAACTTACCG CTACTTCTTG CTGCTCTTTT 360
GGGTGGGCCA GCCCTACCCA ACTCTCTCAA CTCCACTATC AAAGAGGACT AGTGGTTTCC 420
CAGCAAAGAA AAGGGCCCTG GAGCTCTCTG GAAACAGCAA AAATGAGCTG AACCGTTCAA 480
AAAGGAGCTG GATGTGGAAT CAGTTCTTTC TCCTGGAGGA ATACACAGGA TCCGATTATC 540
AGTATGTGGG CAAGTTACAT TCAGACCAGG ATAGAGGAGA TGGATCACTT AAATATATCC 600
45 TTTCAGGAGA TGGAGCAGGA GATCTCTTCA TTATTAATGA AAACACAGGC GACATACAGG 660
CCACCAAGAG GCTGGACAGG GAAGAAAAAC CCGTTTACAT CCTTCGAGCT CAAGCTATAA 720
ACAGAAGGAC AGGGAGACCC GTGGAGCCCG AGTCTGAATT CATCATCAAG ATCCATGACA 780
TCAATGACAA TGAACCAATA TTCACCAAGG AGGTTTACAC AGCCACTGTC CCTGAAATGT 840
CTGATGTCGG TACATTTGTT GTCCAAGTCA CTGCGACGGA TGCAGATGAT CCAACATATG 900
50 GGAACAGTGC TAAAGTTGTC TACAGTATTC TACAGGGACA GCCCTATTTT TCAGTTGAAT 960
CAGAAACAGG TATTATCAAG ACAGCTTTGC TCAACATGGA TCGAGAAAAC AGGGAGCAGT 1020
ACCAAGTGGT GATTCAAGCC AAGGATATGG GCGGCCAGAT GGGAGGATTA TCTGGGACCA 1080
CCACCGTGAA CATCACACTG ACTGATGTCA ACGACAACCC TCCCCGATTC CCCCAGAGTA 1140
CATACCAGTT TAAAACTCCT GAATCTTCTC CACCGGGGAC ACCAATTGGC AGAATCAAAG 1200
55 CCAGCGACGC TGATGTGGGA GAAAATGCTG AAATTGAGTA CAGCATCACA GACGGTGAGG 1260
GGCTGGATAT GTTTGATGTC ATCACCGACC AGGAAACCCA GGAAGGGATT ATAACTGTCA 1320
AAAAGCTCTT GGACTTTGAA AAGAAGAAAG TGTATACCCT TAAAGTGGAA GCCTCCAATC 1380
CTTATGTTGA GCCACGATTT CTCTACTTGG GGCCTTTCAA AGATTCAGCC ACGGTTAGAA 1440
TTGTGGTGGA GGATGTAGAT GAGCCACCTG TCTTCAGCAA ACTGGCCTAC ATCTTACAAA 1500
60 TAAGAGAAGA TGCTCAGATA AACACCACAA TAGGCTCCGT CACAGCCCAA GATCCAGATG 1560
CTGCCAGGAA TCCTGTCAAG TACTCTGTAG ATCGACACAC AGATATGGAC AGAATATTCA 1620
ACATTGATTC TGGAAATGGT TCGATTTTTA CATCGAAACT TCTTGACCGA GAAACACTGC 1680
TATGGCACAA CATTACAGTG ATAGCAACAG AGATCAATAA TCCAAAGCAA AGTAGTCGAG 1740
TACCTCTATA TATTAAAGTT CTAGATGTCA ATGACAACGC CCCAGAATTT GCTGAGTTCT 1800
65 ATGAAACTTT TGTCTGTGAA AAAGCAAAGG CAGATCAGTT GATTCAGACC CTGCATGCTG 1860
TTGACAAGGA TGACCCTTAT AGTGGACACC AATTTTCGTT TTCCTTGGCC CCTGAAGCAG 1920
CCAGTGGCTC AAACTTTACC ATTCAAGACA ACAAAGACAA CACGGCGGGA ATCTTAACTC 1980
GGAAAAATGG CTATAATAGA CACGAGATGA GCACCTATCT CTTGCCTGTG GTCATTTCAG 2040
ACAACGACTA CCCAGTTCAA AGCAGCACTG GGACAGTGAC TGTCCGGGTC TGTGCATGTG 2100
70 ACCACCACGG GAACATGCAA TCCTGCCATG CGGAGGCGCT CATCCACCCC ACGGGACTGA 2160
GCACGGGGGC TCTGGTTGCC ATCCTTCTGT GCATCGTGAT CCTACTAGTG ACAGTGGTGC 2220
TGTTTGCAGC TCTGAGGCGG CAGCGAAAAA AAGAGCCTTT GATCATTTCC AAAGAGGACA 2280
TCAGAGATAA CATTGTCAGT TACAACGACG AAGGTGGTGG AGAGGAGGAC ACCCAGGCTT 2340
TTGATATCGG CACCCTGAGG AATCCTGAAG CCATAGAGGA CAACAAATTA CGAAGGGACA 2400
75 TTGTGCCCGA AGCCCTTTTC CTACCCCGAC GGACTCCAAC AGCTCGCGAC AACACCGATG 2460
TCAGAGATTT CATTAACCAA AGGTTAAAGG AAAATGACAC GGACCCCACT GCCCCGCCAT 2520
ACGACTCCTT GGCCACTTAC GCCTATGAAG GCACTGGCTC CGTGGCGGAT TCCCTGAGCT 2580
CGCTGGAGTC AGTGACCACG GATGCAGATC AAGACTATGA TTACCTTAGT GACTGGGGAC 2640
CTCGATTCAA AAAGCTTGCA GATATGTATG GAGGAGTGGA CAGTGACAAA GACTCCTAAT 2700
80 CTGTTGCCTT TTTCATTTTC CAATACGACA CTGAAATATG TGAAGTGGCT ATTTCTTTAT 2760
ATTTATCCAC TACTCCGTGA AGGCTTCTCT GTTCTACCCG TTCCAAAAGC CAATGGCTGC 2820
AGTCCGTGTG GATCCAATGT TAGAGACTTT TTTCTAGTAC ACTTTTATGA GCTTCCAAGG 2880
GGCAAATTTT TATTTTTTAG TGCATCCAGT TAACCAAGTC AGCCCAACAG GCAGGTGCCG 2940
GAGGGGAGGA CAGGGAACAG TATTTCCACT TGTTCTCAGG GCAGCGTGCC CGCTTCCGCT 3000 GTCCTGGTGT TTTACTACAC TCCATGTCAG GTCAGCCAAC TGCCCTAACT GTACATTTCA 3060
CAGGCTAATG GGATAAAGGA CTGTGCTTTA AAGATAAAAA TATCATCATA GTAAAAGAAA 3120
TGAGGGCATA TCGGCTCACA AAGAGATAAA CTACATAGGG GTGTTTATTT GTGTCACAAA 3180
GAATTTAAAA TAACACTTGC CCATGCTATT TGTTCTTCAA GAACTTTCTC TGCCATCAAC 3240
5 TACTATTCAA AACCTCAAAT CCACCCATAT GTTAAAATTC TCATTACTCT TAAGGAATAG 3300
AAGCAAATTA AACGGTAACA TCCAAAAGCA ACCACAAACC TAGTACGACT TCATTCCTTC 3360
CACTAACTCA TAGTTTGTTA TATCCTAGAC TAGACATGCG AAAGTTTGCC TTTGTACCAT 3420
ATAAAGGGGG AGGGAAATAG CTAATAATGT TAACCAAGGA AATATATTTT ACCATACATT 3 80
TAAAGTTTTG GCCACCACAT GTATCACGGG TCACTTGAAA TTCTTTCAGC TATCAGTAGG 3540 0 CTAATGTCAA AATTGTTTAA AAATTCTTGA AAGAATTTTC CTGAGACAAA TTTTAACTTC 3600
TTGTCTATAG TTGTCAGTAT TATTCTACTA TACTGTACAT GAAAGTAGCA GTGTGAAGTA 3660
CAATAATTCA TATTCTTCAT ATCCTTCTTA CACGACTAAG TTGAATTAGT AAAGTTAGAT 3720
TAAATAAAAC TTAAATCTCA CTCTAGGAGT TCAGTGGAGA GGTTAGAGCC AGCCACACTT 3780
GAACCTAATA CCCTGCCCTT GACATCTGGA AACCTCTACA TATTTATATA ACGTGATACA 840 5 TTTGGATAAA CAACATTGAG ATTATGATGA AAACCTACAT ATTCCATGTT TGGAAGACCC 3900
TTGGAAGAGG AAAATTGGAT TCCCTTAAAC AAAAGTGTTT AAGATTGTAA TTAAAATGAT 3960
AGTTGATTTT CAAAAGCATT AATTTTTTTT CATTGTTTTT AACTTTGCTT TCATGACCAT 4020
CCTGCCATCC TTGACTTTGA ACTAATGATA AAGTAATGAT CTCAAACTAT GACAGAAAAG 4080
TAATGTAAAA TCCATCCAAT CTATTATTTC TCTAATTATG CAATTAGCCT CATAGTTATT 4140 0 ATCCAGAGGA CCCAACTGAA CTGAACTAAT CCTTCTGGCA GATTCAAATC GTTTATTTCA 4200
CACGCTGTTC TAATGGCACT TATCATTAGA ATCTTACCTT GTGCAGTCAT CAGAAATTCC 4260
AGCGTACTAT AATGAAAACA TCCTTGTTTT GAAAACCTAA AAGACAGGCT CTGTATATAT 4320
ATATACTTAA GAATATGCTG ACTTCACTTA TTAGTCTTAG GGATTTATTT TCAATTAATA 4380
TTAATTTTCT ACAAATAATT TTAGTGTCAT TTCCATTTGG GGATATTGTC ATATCAGCAC 4440 5 ATATTTTCTG TTTGGAAACA CACTGTTGTT TAGTTAAGTT TTAAATAGGT GTATTACCCA 4500
AGAAGTAAAG ATGGAAACGT T 4521
Seq ID NO 50 DNA Sequence
Nucleic Acid Accession H Eos sequence 0 1 11 21 31 41 51
I I I I I I τττττττχττ TTTTTAGAAA AAAACCAGTT TATTAAGTAA TATCATATAA ATAACTTGTT 60
ACAAAAATTG ATTTGCAAAA GGCATATTTA CTCTTTGTGA GAAATCACTT TTTAAATTGC 120
ATTCTTTTCA AATTTATAAG TCTAAGAAAA CAAAACCAAA TAAAAGAAGC CATTTCAAGG 180 5 AGTGCGTATT TGCCATTTGA CTGCAACAAA AGGCCCGGCC ACACTGAGCT AAAAGGTAAT 240
ACTCTCGACC CCATTCTTCT AACACAGAAA ACTTTCTCAG GTAAACTGTG GGGTTATGAG 300
AATCCCCCTA ACTAGAAATG TTGATGGGAA CTGAGCATTG CTTGCTTTCA TCAGGTGTTC 360
TTGTTGCCAA AGACATGAAC GATACTGAGG AAAACGACAA GAGTGAGCAT TCCCGCCAGT 420
AAATCTTCAA GGGTGGCATC CGTTTCAATT TATACTTGGA AGTATTTTTA ATTAAAAACA 480 0 ATCAATACCA AAAAGCTTTT ATTTTGTGGG TTTAAAAGTC ACAAATCACA GTGGGAGAAT 540
GCCAAATTGC TTTAGCTTGG AACTACTGAA GACGCACATA GCATTTATTA TAAGGCCTAC 600
TCTTAGGCAG TTCACTCTCA AAGCAATGAA AATAATCTCA AACCAAACAT TACAGTGGGT 660
TTGAAGCGTT CCTACGTTTC TTCCGAGCAG GTCAGTTTTA CATTTGCTAC ACAGCATTCC 720
CCACGAATGC CTGGTAATTC TATACATTTG ATTCTTTAAT AAACACTAAA CTAATAGATC 780 5 ATAGAAAACT AAAAGCTTAG AGAAGGTGCC TCCAGACATA TTTACATAAA TAACGTAGCC 840
TCACAAGAAA GACCAAGATC TCATTAGCGT GGAATGCTTT TTCCACAAGG CTGGGTCCAT 900
GCCTCATTTG TCAGATTAAC CCCATTTGAG GAGAAATTTG AGTTTGTGGT TCATGGGTTT 960
TTGAAAAAAA AAAAAAAAAA AAAATTAAGC AACTTGT AA AGCTCTTTTG AAATTAATCT 1020
AATAACCCAG TGGCTCCTCG GCTAAGTGCC TCAGTCCTGT CTGAAATACA GCGGGTAAGA 1080 0 GCCTTTGTTT CCATTTGACC TCTTTTCAAC ACTTTCATCT GCCGGCTCTG TTGGGCTAAC 1140
GTTTCCCCCA AATAAAAATG AAAATGCACC ATAAATAAGG TATTACAAAA AGGGGAGTAG 1200
ATTAAAGATT GTCTCAGCAA TGCTTAAATT AAATTGACGA TGCAGAGACC ATAAACTTCC 1260
GGCTTTAAAA ATGAGCTATT TCTTTATTAA CTTTTAACAA GTGTATGAGT CAATGTATTT 1320
TCTTTCTAAG AGGGTATTGC TCTCCACATT AAATATGGTC GGGGTCTGAT ATTTTTAGTA 1380 5 GAGAATTACC CTTTAGAAAA TTATTCCATA AAGATGCCAT AGGGAGATTA AAAATGCTGT 1440
GACCATAAGA GCTACTAAAC ATTTAAGGAG ACCATAATAT AATTCTATAT TCTCTGGAAA 1S00
AGGAAGCTGC TTGTTTGAGC TTATGAAATA GCTCATTTTC CTGAAGATTC ACACACCAAG 1560
TGTTAATTTT TCTACTCTTA TAATCTGATA AGGAAGGTTG TGGTGTTAAT TTAAACACAG 1620
TAGACTGCTT GGATTTTTGA GTCCCCTTTT ATAATATCAC AATTCAAACA AGATTTCATC 1680 0 TTGATAAACA TAAAAATTAA GATTACACTA TAATGATCCT TGTTAGAGGA TACATTTCAA 1740
AATAGTGGGG GAATCATGAC TTTTTAGAGC CTTCTTCCAG AGTAATTACA CTGCTTCAAA 1800
ACTAGTTATT AGGATAAAAT AATTTATTTG GTGGTCTGTT CCTGGTGAAA ATGAATTTAG 1860
CTGATAAGGA TGAGTACCTG ATTTGAATAT TTAGTTGGCA CCCAGGAGTC AACTTTGATT 1920
TTCTTTTCAA CTGCATACTT TTTATGGTGC TTGAGTATAT AGAATTGTCC AAGTCATAGT 1980 5 TTACACACCA CTATCCCCAG TGGGATATCT ATTTCCAGGC AAAGCATTTG ATGTGAGATA 2040
TTGTTCAGCC AATCAGGACA CTTAAAATTT ATATATGTAA AAGTGAAAGT AATAGAAACA 2100
TTCTAAAGTT AATTTGGATT TATAAAATTT GGATGGCCTA AGCTACAGAT TCAATTTTTA 2160
AGGCCGGGCG CGGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCCG AGGCGGGAGA 2220
ATGGCGTGAA CCCGGGAGGC GGAGCTTGTA GTGAGCAGAG ATCGCGCCAC TGCATTCCAG 2280
70 CCTGGGCGAC AGAGCGAGAT TCTGTCTCAA AAAAAAAAAA AAAAAGAAAC TTATCGATAC 2340
CCC 2343
Seq ID NO 51 DNA Sequence Nucleic Acid Accession # Eos sequence /5 Coding sequence 640 2313
1 11 21 31 41 51
I I I I I I
GGCATCCCGA GTGCACCGCT CCCGCCCCGC CCCGCCTTGC CCCAACCCAC GATGGTCTGG 60
O Λ GAGCTGCGCC CAGGGCTTGG CGCTGGCGGC CCCGCAACAG CACCGAGCGT TTCGGTCGGC 120
80 GGGCGGCGGT AGCGCCCCCT CTCAGAGCCC CGCTCACTCC CACCTGGGCT CGCTCCGAGT 180
CGGCCTGTCT GTCGGGCCCG CCCTCCCCGC TCACTCCCTC CGCCTCGTGC TCCTCCCGGG 240
GTGCTTGGCA CAGCCTCGGA TTCCTCCCTC TCGCTGCTCG AGTCAGTTTC CCTATCGGCG 300
GCAGCGGGCA AGGCGGCGGC GGCGGCGGCG GCAGCCGCGG TGGCGGCGTG GGGAACATCT 360
CGGCAGCCAC CGCGCTTCTC CCGCTGGAGC GGGCGTCCAG CTTGGCTGCC CTCGGTCCTT 420 CCCTGCCACG TTTCGGGTCG CCCTGCACCC CCCACCCAGG CTCGCTTCTC TTCGAAGCGG 480
GAAGGGCGCC TTGCAGGATC CTGCCGCCCC TCCAACCGGA TCCTGGGTCT AGAGCTCCCC 540
AGAGCGAGGC GCTCGCCAGG ACTCCTGCCC CGCCAACCCT GACCGCCGGG GGGTGCCCCC 600
GGGACGTAGC GCCGCGGAGA GGAAGCGGCA AAGGGGACCA TGCGGCGCCT GACTCGTCGG 660
CTGGTTCTGC CAGTCTTCGG GGTGCTCTGG ATCACGGTGC TGCTGTTCTT CTGGGTAACC 720
AAGAGGAAGT TGGAGGTGCC GACGGGACCT GAAGTGCAGA CCCCTAAGGT TTGGTCCTTG 780
TTTTTCAAGG TGGCTGGGAT GAGCCCTTGG GCGCCTCAGG TGCCTGTATC ACCCACTCCT 840
CCCTACCAAA GAGGGCATCT TCCTACAGGA GGACACCTTG CTGTATGTCA TTTCCCATGT 900
CTCTTGCAAG AAGCTCAGTT CCATTTGCAG ACTCAGGTCT TTCTTCAAGT CAGATGCACA 960
CTGCTGGTGT ATTGCACGGA CCTTCCACCC ACTAGCATCA TCATCACCTT CCACAACGAG 1020
GCCCGCTCCA CGCTGCTCAG GACCATCCGC AGTGTATTAA ACCGCACCCC TACGCATCTG 1080
ATCCGGGAAA TCATATTAGT GGATGACTTC AGCAATGACC CTGATGACTG TAAACAGCTC 1140
ATCAAATTGC CCAAGGTGAA ATGCTTGCGC AATAATGAAC GGCAAGGTCT GGTCCGGTCC 1200
CGGATTCGGG GCGCTGACAT CGCCCAGGGC ACCACTCTGA CTTTCCTCGA CAGCCACTGT 1260
GAGGTGAACA GGGACTGGCT CCAGCCTCTG TTGCACAGGG TCAAAGAGGA CTACACGCGG 1320
GTGGTGTGCC CTGTGATCGA TATCATTAAC CTGGACACCT TCACCTACAT CGAGTCTGCC 1380
TCGGAGCTCA GAGGGGGGTT TGACTGGAGC CTCCACTTCC AGTGGGAGCA GCTCTCCCCA 1440
GAGCAGAAGG CTCGGCGCCT GGACCCCACG GAGCCCATCA GGACTCCTAT CATAGCTGGA IS00
GGGCTCTTCG TGATCGACAA AGCTTGGTTT GATTACCTGG GGAAATATGA TATGGACATG 1560
GACATCTGGG GTGGGGAGAA CTTTGAAATC TCCTTCCGAG TGTGGATGTG CGGGGGCAGC 1620
CTAGAGATCG TCCCCTGCAG CCGAGTGGGG CACGTCTTCC GGAAGAAGCA CCCCTACGTT 1680
TTCCCTGATG GAAATGCCAA CACGTATATA AAGAACACCA AGCGGACAGC TGAAGTGTGG 1740
ATGGATGAAT ACAAGCAATA CTATTACGCT GCCCGGCCAT TCGCCCTGGA GAGGCCCTTC 1800
GGGAATGTTG AGAGCAGATT GGACCTGAGG AAGAATCTGC GCTGCCAGAG CTTCAAGTGG 1860
TACCTGGAGA ATATCTACCC TGAACTCAGC ATCCCCAAGG AGTCCTCCAT CCAGAAGGGC 1920
AATATCCGAC AGAGACAGAA GTGCCTGGAA TCTCAAAGGC AGAACAACCA AGAAACCCCA 1980
AACCTAAAGT TGAGCCCCTG TGCCAAGGTC AAAGGCGAAG ATGCAAAGTC CCAGGTATGG 2040
GCCTTCACAT ACACCCAGCA GATCCTCCAG GAGGAGCTGT GCCTGTCAGT CATCACCTTG 2100
TTCCCTGGCG CCCCAGTGGT TCTTGTCCTT TGCAAGAATG GAGATGACCG ACAGCAATGG 2160
ACCAAAACTG GTTCCCACAT CGAGCACATA GCATCCCACC TCTGCCTCGA TACAGATATG 2220
TTCGGTGATG GCACCGAGAA CGGCAAGGAA ATCGTCGTCA ACCCATGTGA GTCCTCACTC 2280
ATGAGCCAGC ACTGGGACAT GGTGAGCTCT TGAGGACCCC TGCCAGAAGC AGCAAGGGCC 2340
ATGGGGTGGT GCTTCCCTGG ACCAGAACAG ACTGGAAACT GGGCAGCAAG CAGCCTGCAA 2400
CCACCTCAGA CATCCTGGAC TGGGAGGTGG AGGCAGAGCC CCCCAGGACA GGAGCAACTG 2460
TCTCAGGGAG GACAGAGGAA AACATCACAA GCCAATGGGG CTCAAAGACA AATCCCACAT 2520
GTTCTCAAGG CCGTTAAGTT CCAGTCCTGG CCAGTCATTC CCTGATTGGT ATCTGGAGAC 2580
AGAAACCTAA TGGGAAGTGT TTATTGTTCC TTTTCCTACA AAGGAAGCAG TCTCTGGAGG 2640
CCAGAAAGAA AAGCCTTCTT TTTCACTAGG CCAGGACTAC ATTGAGAGAT GAAGAATGGA 2700
GGTTGTTTCC AAAAGAAATA AAGAGAAACT TAGAAGTTGT CTCTGG 2746
Seq ID NO: 52 DNA Sequence
Nucleic Acid Accession t : Eos sequence
Coding sequence: 641..2299
1 11 21 31 41 51 i i i i i i
GGCATCCCGA GTGCACCGCT CCCGCCCCGC CCCGCCTTGC CCCAACCCAC GATGGTCTGG 60
GAGCTGCGCC CAGGGCTTGG CGCTGGCGGC CCCGCAACAG CACCGAGCGT TTCGGTCGGC 120
GGGCGGCGGT AGCGCCCCCT CTCAGAGCCC CGCTCACTCC CACCTGGGCT CGCTCCGAGT 180
CGGCCTGTCT GTCGGGCCCG CCCTCCCCGC TCACTCCCTC CGCCCTCGTG CTCCTCCCGG 240
GGTGCTTGGC ACAGCCTCGG ATTCCTCCCT CTCGCTGCTC GAGTCAGTTT CCCTATCGGC 300
GGCAGCGGGC AAGGCGGCGG CGGCGGCGGC GGCAGCCGCG GTGGCGGCGT GGGGAACATC 360
TCGGCAGCCA CCGCGCTTCT CCCGCTGGAG CGGGCGTCCA GCTTGGCTGC CCTCGGTCCT 420
TCCCTGCCAC GTTTCGGGTC GCCCTGCACC CCCCACCCAG GCTCGCTTCT CTTCGAAGCG 480
GGAAGGGCGC CTTGCAGGAT CCTGCCGCCC CTCCAACCGG ATCCTGGGTC TAGAGCTCCC 540
CAGAGCGAGG CGCTCGCCAG GACTCCTGCC CCGCCAACCC TGACCGCCGG GGGGTGCCCC 600
CGGGACGTAG CGCCGCGGAG AGGAAGCGGC AAAGGGGACC ATGCGGCGCC TGACTCGTCG 660
GCTGGTTCTG CCAGTCTTCG GGGTGCTCTG GATCACGGTG CTGCTGTTCT TCTGGGTAAC 720
CAAGAGGAAG TTGGAGGTGC CGACGGGACC TGAAGTGCAG ACCCCTAAGC CTTCGGACGC 780
TGACTGGGAC GACCTGTGGG ACCAGTTTGA TGAGCGGCGG TATCTGAATG CCAAAAAGTG 840
GCGCGTTGGT GACGACCCCT ATAAGCTGTA TGCTTTCAAC CAGCGGGAGA GTGAGCGGAT 900
CTCCAGCAAT CGGGCCATCC CGGACACTCG CCATCTGAGA TGCACACTGC TGGTGTATTG 960
CACGGACCTT CCACCCACTA GCATCATCAT CACCTTCCAC AACGAGGCCC GCTCCACGCT 1020
GCTCAGGACC ATCCGCAGTG TATTAAACCG CACCCCTACG CATCTGATCC GGGAAATCAT 1080
ATTAGTGGAT GACTTCAGCA ATGACCCTGA TGACTGTAAA CAGCTCATCA AATTGCCCAA 1140
GGTGAAATGC TTGCGCAATA ATGAACGGCA AGGTCTGGTC CGGTCCCGGA TTCGGGGCGC 1200
TGACATCGCC CAGGGCACCA CTCTGACTTT CCTCGACAGC CACTGTGAGG TGAACAGGGA 1260
CTGGCTCCAG CCTCTGTTGC ACAGGGTCAA AGAGGACTAC ACGCGGGTGG TGTGCCCTGT 1320
GATCGATATC ATTAACCTGG ACACCTTCAC CTACATCGAG TCTGCCTCGG AGCTCAGAGG 1380
GGGGTTTGAC TGGAGCCTCC ACTTCCAGTG GGAGCAGCTC TCCCCAGAGC AGAAGGCTCG 1440
GCGCCTGGAC CCCACGGAGC CCATCAGGAC TCCTATCATA GCTGGAGGGC TCTTCGTGAT 1500
CGACAAAGCT TGGTTTGATT ACCTGGGGAA ATATGATATG GACATGGACA TCTGGGGTGG 1560
GGAGAACTTT GAAATCTCCT TCCGAGTGTG GATGTGCGGG GGCAGCCTAG AGATCGTCCC 1620
CTGCAGCCGA GTGGGGCACG TCTTCCGGAA GAAGCACCCC TACGTTTTCC CTGATGGAAA 1680
TGCCAACACG TATATAAAGA ACACCAAGCG GACAGCTGAA GTGTGGATGG ATGAATACAA 1740
GCAATACTAT TACGCTGCCC GGCCATTCGC CCTGGAGAGG CCCTTCGGGA ATGTTGAGAG 1800
CAGATTGGAC CTGAGGAAGA ATCTGCGCTG CCAGAGCTTC AAGTGGTACC TGGAGAATAT 1860
CTACCCTGAA CTCAGCATCC CCAAGGAGTC CTCCATCCAG AAGGGCAATA TCCGACAGAG 1920
ACAGAAGTGC CTGGAATCTC AAAGGCAGAA CAACCAAGAA ACCCCAAACC TAAAGTTGAG 1980
CCCCTGTGCC AAGGTCAAAG GCGAAGATGC AAAGTCCCAG GTATGGGCCT TCACATACAC 2040
CCAGCAGATC CTCCAGGAGG AGCTGTGCCT GTCAGTCATC ACCTTGTTCC CTGGCGCCCC 2100
AGTGGTTCTT GTCCTTTGCA AGAATGGAGA TGACCGACAG CAATGGACCA AAACTGGTTC 2160
CCACATCGAG CACATAGCAT CCCACCTCTG CCTCGATACA GATATGTTCG GTGATGGCAC 2220
CGAGAACGGC AAGGAAATCG TCGTCAACCC ATGTGAGTCC TCACTCATGA GCCAGCACTG 2280
GGACATGGTG AGCTCTTGAG GACCCCTGCC AGAAGCAGCA AGGGCCATGG GGTGGTGCTT 2340 CCCTGGACCA GAACAGACTG GAAACTGGGC AGCAAGCAGC CTGCAACCAC CTCAGACATC 2400
CTGGACTGGG AGGTGGAGGC AGAGCCCCCC AGGACAGGAG CAACTGTCTC AGGGAGGACA 2460
GAGGAAAACA TCACAAGCCA ATGGGGCTCA AAGACAAATC CCACATGTTC TCAAGGCCGT 2520
TAAGTTCCAG TCCTGGCCAG TCATTCCCTG ATTGGTATCT GGAGACAGAA ACCTAATGGG 2580 AAGTGTTTAT TGTTCCTTTT CCTACAAAGG AAGCAGTCTC TGGAGGCCAG AAAGAAAAGC 2640
CTTCTTTTTC ACTAGGCCAG GACTACATTG AGAGATGAAG AATGGAGGTT GTTTCCAAAA 2700
GAAATAAAGA GAAACTTAGA AGTTGAAAAA AAAAAAAAAA A 2741
Seq ID NO 53 DNA Sequence Nucleic Acid Accession tt Eos sequence Coding sequence 400 1959 1 11 21 31 41 51
I I I I I I
GGCATCCCGA GTGCACCGCT CCCGCCCCGC CCCGCCTTGC CCCAACCCAC GATGGTCTGG 60 GAGCTGCGCC CAGGGCTTGG CGCTGGCGGC CCCGCAACAG CACCGAGCGT TTCGGTCGGC 120
GGGCGGCGGT AGCGCCCCCT CTCAGAGCCC CGCTCACTCC CACCTGGGCT CGCTCCGAGT 180
CGGCCTGTCT GTCGGGCCCG CCCTCCCCGC TCACTCCCTC CGcCCTTCTC TTCGAAGCGG 240
GAAGGGCGCC TTGCAGGATC CTGCCGCCCC TCCAACCGGA TCCTGGGTCT AGAGCTCCCC 300
AGAGCGAGGC GCTCGCCAGG ACTCCTGCCC CGCCAACCCT GACCGCCGGG GGGTGCCCCC 360 GGGACGTAGC GCCGCGGAGA GGAAGCGGCA AAGGGGACCA TGCGGCGCCT GACTCGTCGG 420
CTGGTTCTGC CAGTCTTCGG GGTGCTCTGG ATCACGGTGC TGCTGTTCTT CTGGGTAACC 480
AAGAGGAAGT TGGAGGTGCC GACGGGACCT GAAGTGCAGA CCCCTAAGCC TTCGGACGCt S40
GACTGGGACG ACCTGTGGGA CCAGTTTGAT GAGCGGCGGT ATCTGAATGC CAAAAAGTGG 600
CGCGTTGGTG ACGACCCCTA TAAGCTGTAT GCTTTCAACC AGCGGGAGAG TGAGCGGATC 660 TCCAGCAATC GGGCCATCCC GGACACTCGC CATCTGAGTG TATTAAACCG CACCCCTACG 720
CATCTGATCC GGGAAATCAT ATTAGTGGAT GACTTCAGCA ATGACCCTGA TGACTGTAAA 780
CAGCTCATCA AgTTGCCCAA GGTGAAATGC TTGCGCAATA ATGAACGGCA AGGTCTGGTC 840
CGGTCCCGGA TTCGGGGCGC TGACATCGCC CAGGGCACCA CTCTGACTTT CCTCGACAGC 900
CACTGTGAGG TGAACAGGGA CTGGCTCCAG CCTCTGTTGC ACAGGGTCAA AGAGGACTAC 960 ACGCGGGTGG TGTGCCCTGT GATCGATATC ATTAACCTGG ACACCTTCAC CTACATCGAG 1020
TCTGCCTCGG AGCTCAGAGG GGGGTTTGAC TGGAGCCTCC ACTTCCAGTG GGAGCAGCTC 1080
TCCCCAGAGC AGAAGGCTCG GCGCCTGGAC CCCACGGAGC CCATCAGGAC TCCTATCATA 1140
GCTGGAGGGC TCTTCGTGAT CGACAAAGCT TGGTTTGATT ACCTGGGGAA ATATGATATG 1200
GACATGGACA TCTGGGGTGG GGAGAACTTT GAAATCTCCT TCCGAGTGTG GATGTGCGGG 1260 GGCAGCCTAG AGATCGTCCC CTGCAGCCGA GTGGGGCACG TCTTCCGGAA GAAGCACCCC 1320
TACGTTTTCC CTGATGGAAA TGCCAACACG TATATAAAGA ACACCAAGCG GACAGCTGAA 1380
GTGTGGATGG ATGAATACAA GCGATACTAT TACGCTGCCC GGCCATTCGC CCTGGAGAGG 1440
CCCTTCGGGA ATGTTGAGAG CAGATTGGAC CTGAGGAAGA ATCTGCGCTG CCAGAGCTTC 1S00
AAGTGGTACC TGGAGAATAT CTACCCTGAA CTCAGCATCC CCAAGGAGTC CTCCATCCAG 1560 AAGGGCAATA TCCGACAGAG ACAGAAGTGC CTGGAATCTC AAAGGCAGAA CAACCAAGAA 1620
ACCCCAAACC TAAAGTTGAG CCCCTGTGCC AAGGTCAAAG GCGAAGATGC AAAGTCCCAG 1680
GTATGGGCCT TCACATACAC CCAGCAGATC CTCCAGGAGG AGCTGTGCCT GTCAGTCATC 1740
ACCTTGTTCC CTGGCGCCCC AGTGGTTCTT GTCCTTTGCA AGAATGGAGA TGACCGACAG 1800
CAATGGACCA AAACTGGTTC CCACATCGAG CACATAGCAT CCCACCTCTG CCTCGATACA 1860 GATATGTTCG GTGATGGCAC CGAGAACGGC AAGGAAATCG TCGTCAACCC ATGTGAGTCC 1920
TCACTCATGA GCCAGCACTG GGACATGGTG AGCTCTTGAG GACCCCTGCC AGAAGCAGCA 1980
AGGGCCATGG GGTGGTGCTT CCCTGGACCA GAACAGACTG GAAACTGGGC AGCAAGCAGC 2040
CTGCAACCAC CTCAGACATC CTGGACTGGG AGGTGGAGGC AGAGCCCCCC AGGACAGGAG 2100
CAACTGTCTC AGGGAGGACA GAGGAAAACA TCACAAGCCA ATGGGGCTCA AAGACAAATC 2160 CCACATGTTC TCAAGGCCGT TAAGTTCCAG TCCTGGCCAG TCATTCCCTG ATTGGTATCT 2220
GGAGACAGAA ACCTAATGGG AAGTGTTTAT TGTTCCTTTT CCTACAAAGG AAGCAGTCTC 2280
TGGAGGCCAG AAAGAAAAGC CTTCTTTTTC ACTAGGCCAG GACTACATTG AGAGATGAAG 2340
AATGGAGGTT GTTTCCAAAA GAAATAAAGA GAAACTTAGA AGTTG 2385 Seq ID NO 54 DNA Sequence
Nucleic Acid Accession tl Eos sequence
Coding sequence 1241 2377
1 11 21 31 41 51
I I I I I I
GGCATCCCGA GTGCACCGCT CCCGCCCCGC CCCGCCTTGC CCCAACCCAC GATGGTCTGG 60
GAGCTGCGCC CAGGGCTTGG CGCTGGCGGC CCCGCAACAG CACCGAGCGT TTCGGTCGGC 120
GGGCGGCGGT AGCGCCCCCT CTCAGAGCCC CGCTCACTCC CACCTGGGCT CGCTCCGAGT 180
CGGCCTGTCT GTCGGGCCCG CCCTCCCCGC TCACTCCCTC CGcCCTCGTG CTCCTCCCGG 240
GGTGCTTGGC ACAGCCTCGG ATTCCTCCCT CTCGCTGCTC GAGTCAGTTT CCCTATCGGC 300
GGCAGCGGGC AAGGCGGCGG CGGCGGCGGC GGCAGCCGCG GTGGCGGCGT GGGGAACATC 360
TCGGCAGCCA CCGCGCTTCT CCCGCTGGAG CGGGCGTCCA GCTTGGCTGC CCTCGGTCCT 420
TCCCTGCCAC GTTTCGGGTC GCCCTGCACC CCCCACCCAG GCTCGCTTCT CTTCGAAGCG 480
GGAAGGGCGC CTTGCAGGAT CCTGCCGCCC CTCCAACCGG ATCCTGGGTC TAGAGCTCCC 540
CAGAGCGAGG CGCTCGCCAG GACTCCTGCC CCGCCAACCC TGACCGCCGG GGGGTGCCCC 600
CGGGACGTAG CGCCGCGGAG AGGAAGCGGC AAAGGGGACC ATGCGGCGCC TGACTCGTCG 660
GCTGGTTCTG CCAGTCTTCG GGGTGCTCTG GATCACGTGC TGCTGTTCTT CTGGGTAACC 720
AAGAGGAAGT GGAGGTGCCG ACGGGACCTG AAGTGCAGAC CCCTAAGGGT TCTTCCCAAA 780
GTTAGTGCAG CCTACACCCA GGATTGAACA AAGACAGCTT GGAAGTTAGA AGCAAGATGG 840 AGTCTGTTAG CCTTCGGACG CTGACTGGGA CGACCTGTGG GACCAGTTTG ATGAGCGGCG 900 GTATCTGAAT GCCAAAAAGT GGCGCGTTGG TGACGACCCC TATAAGCTGT ATGCTTTCAA 960 CCAGCGGGAG AGTGAGCGGA TCTCCAGCAA TCGGGCCATC CCGGACACTC GCCATCTGAG 1020 ATGCACACTG CTGGTGTATT GCACGGACCT TCCACCCACT AGCATCATCA TCACCTTCCA 1080 CAACGAGGCC CGCTCCACGC TGCTCAGGAC CATCCGCAGT GTATTAAACC GCACCCCTAC 1140 GCATCTGATC CGGGAAATCA TATTAGTGGA TGACTTCAGC AATGACCCTG ATGACTGTAA 1200 ACAGCTCATC AAgTTGCCCA AGGTGAAATG CTTGCGCATA ATGAACGGCA AGGTCTGGTC 1260 CGGTCCCGGA TTCGGGGCGC TGACATCGCC CAGGGCACAC TCTGACTTTC TCGACAGCCA 1320 CTGTGAGGTG AACAGGGACT GGCTCCAGCC TCTGTTGCAC AGGGTCAAAG AGGACTACAC 1380 GCGGGTGGTG TGCCCTGTGA TCGATATCAT TAACCTGGAC ACCTTCACCT ACATCGAGTC 1440 TGCCTCGGAG CTCAGAGGGG GGTTTGACTG GAGCCTCCAC TTCCAGTGGG AGCAGCTCTC 1500 CCCAGAGCAG AAGGCTCGGC GCCTGGACCC CACGGAGCCC ATCAGGACTC CTATCATAGC 1560
TGGAGGGCTC TTCGTGATCG ACAAAGCTTG GTTTGATTAC CTGGGGAAAT ATGATATGGA 1620
CATGGACATC TGGGGTGGGG AGAACTTTGA AATCTCCTTC CGAGTGTGGA TGTGCGGGGG 1680
CAGCCTAGAG ATCGTCCCCT GCAGCCGAGT GGGGCACGTC TTCCGGAAGA AGCACCCCTA 1740 CGTTTTCCCT GATGGAAATG CCAACACGTA TATAAAGAAC ACCAAGCGGA CAGCTGAAGT 1800
GTGGATGGAT GAATACAAGC AATACTATTA CGCTGCCCGG CCATTCGCCC TGGAGAGGCC 1860
CTTCGGGAAT GTTGAGAGCA GATTGGACCT GAGGAAGAAT CTGCGCTGCC AGAGCTTCAA 1920
GTGGTACCTG GAGAATATCT ACCCTGAACT CAGCATCCCC AAGGAGTCCT CCATCCAGAA 1980
GGGCAATATC CGACAGAGAC AGAAGTGCCT GGAATCTCAA AGGCAGAACA ACCAAGAAAC 2040 CCCAAACCTA AAGTTGAGCC CCTGTGCCAA GGTCAAAGGC GAAGATGCAA AGTCCCAGGT 2100
ATGGGCCTTC ACATACACCC AGCAGATCCT CCAGGAGGAG CTGTGCCTGT CAGTCATCAC 2160
CTTGTTCCCT GGCGCCCCAG TGGTTCTTGT CCTTTGCAAG AATGGAGATG ACCGACAGCA 2220
ATGGACCAAA ACTGGTTCCC ACATCGAGCA CATAGCATCC CACCTCTGCC TCGATACAGA 2280
TATGTTCGGT GATGGCACCG AGAACGGCAA GGAAATCGTC GTCAACCCAT GTGAGTCCTC 2340 ACTCATGAGC CAGCACTGGG ACATGGTGAG CTCTTGAGGA CCCCTGCCAG AAGCAGCAAG 2400
GGCCATGGGG TGGTGCTTCC CTGGACCAGA ACAGACTGGA AACTGGGCAG CAAGCAGCCT 2460
GCAACCACCT CAGACATCCT GGACTGGGAG GTGGAGGCAG AGCCCCCCAG GACAGGAGCA 2520
ACTGTCTCAG GGAGGACAGA GGAAAACATC ACAAGCCAAT GGGGCTCAAA GACAAATCCC 2580
ACATGTTCTC AAGGCCGTTA AGTTCCAGTC CTGGCCAGTC ATTCCCTGAT TGGTATCTGG 2640 AGACAGAAAC CTAATGGGAA GTGTTTATTG TTCCTTTTCC TACAAAGGAA GCAGTCTCTG 2700
GAGGCCAGAA AGAAAAGCCT TCTTTTTCAC TAGGCCAGGA CTACATTGAG AGATGAAGAA 2760
TGGAGGTTGT TTCCAAAAGA AATAAAGAGA AACTTAGAAG TTG 2803
Seq ID NO: 55 DNA Sequence
Nucleic Acid Accession tt : NM_001218
Coding sequence. 1..1080
1 11 21 31 41 51
I I I I I I
GTACTCGCCA CGGCACCCAG GCTGCGCGCA CGCGGTCCCG GTGTGCAGCT GGAGAGCGAG 60
CGGCCACCGG GAGCCCCCGG CACAGCCCGC GCCCGCCCCG CAGGAGCCCG CGAAGATGCC 120
CCGGCGCAGC CTGCACGCGG CGGCCGTGCT CCTGCTGGTG ATCTTAAAGG AACAGCCTTC 180
CAGCCCGGCC CCAGTGAACG GTTCCAAGTG GACTTATTTT GGTCCTGATG GGGAGAATAG 240
CTGGTCCAAG AAGTACCCGT CGTGTGGGGG CCTGCTGCAG TCCCCCATAG ACCTGCACAG 300
TGACATCCTC CAGTATGACG CCAGCCTCAC GCCCCTCGAG TTCCAAGGCT ACAATCTGTC 360
TGCCAACAAG CAGTTTCTCC TGACCAACAA TGGCCATTCA GTGAAGCTGA ACCTGCCCTC 420
GGACATGCAC ATCCAGGGCC TCCAGTCTCG CTACAGTGCC ACGCAGCTGC ACCTGCACTG 480
GGGGAACCCG AATGACCCGC ACGGCTCTGA GCACACCGTC AGCGGACAGC ACTTCGCCGC 540
CGAGCTGCAC ATTGTCCATT ATAACTCAGA CCTTTATCCT GACGCCAGCA CTGCCAGCAA 600
CAAGTCAGAA GGCCTCGCTG TCCTGGCTGT TCTCATTGAG ATGGGCTCCT TCAATCCGTC 660
CTATGACAAG ATCTTCAGTC ACCTTCAACA TGTAAAGTAC AAAGGCCAGG AAGCATTCGT 720
CCCGGGATTC AACATTGAAG AGCTGCTTCC GGAGAGGACC GCTGAATATT ACCGCTACCG 780
GGGGTCCCTG ACCACACCCC CTTGCAACCC CACTGTGCTC TGGACAGTTT TCCGAAACCC 840
CGTGCAAATT TCCCAGGAGC AGCTGCTGGC TTTGGAGACA GCCCTGTACT GCACACACAT 900
GGACGACCCT TCCCCCAGAG AAATGATCAA CAACTTCCGG CAGGTCCAGA AGTTCGATGA 960
GAGGCTGGTA TACACCTCCT TCTCCCAAGT GCAAGTCTGT ACTGCGGCAG GACTGAGTCT 1020
GGGCATCATC CTCTCACTGG CCCTGGCTGG CATTCTTGGC ATCTGTATTG TGGTGGTGGT 1080
GTCCATTTGG CTTTTCAGAA GGAAGAGTAT CAAAAAAGGT GATAACAAGG GAGTCATTTA 1140
CAAGCCAGCC ACCAAGATGG AGACTGAGGC CCACGCTTGA GGTCCCCGGA GCTCCCGGGC 1200
ACATCCAGGA AGGACCTTGC TTTGGACCCT ACACACTTCG GCTCTCTGGA CACTTGCGAC 1260
ACCTCAAGGT GTTCTCTGTA GCTCAATCTG CAAACATGCC AGGCCTCAGG GATCCTCTGC 1320
TGGGTGCCTC CTTGCCTTGG GACCATGGCC ACCCCAGAGC CATCCGATCG ATGGATGGGA 1380
TGCACTCTCA GACCAAGCAG CAGGAATTCA AAGCTGCTTG CTGTAACTGT GTGAGATTGT 1440
GAAGTGGTCT GAATTCTGGA ATCACAAACC AAGCCATGCT GGTGGGCCAT TAATGGTTGG 1500
AAAACACTTT CATCCGGGGC TTTGCCAGAG CGTGCTTTCA AGTGTCCTGG AAAGTCTGCT 1560
GCTTCTCCAA GCTTTCAGAC AAGAATGTGC ACTCTCTGCT TAGGTTTTGC TTGGGAAACT 1620
CAACTTCTTT CCTCTGGAGA CGGGGCATCT CCCTCTGATT TCCTTCTGCT ATGACAAAAC 1680
CTTTAATCTG CACCTTACAA CTCGGGGACA AATGGGGACA GGAAGGATCA AGTTGTAGAG 1740
AGAAAAAAGA AAACAAGAGA TATACATTGT GATATATTAG GGACACTTTC ACAGTCCTGT 1800
CCTCTGGATC ACAGACACTG CACAGACCTT AGGGAATGGC AGGTTCAAGT TCCACTTCTT 1860
GGTGGGGATG AGAAGGGAGA GAGAGCTAGA GGGACAAAGA GAATGAGAAG ACATGGATGA 1920
TCTGGGAGAG TCTCACTTTG GAATCAGAAT TGGAATCACA TTCTGTTTAT CAAGCCATAA 1980
TGTAAGGACA GAATAATACA ATATTAAGTC CAAATCCAAC CTCCTGTCAG TGGAGCAGTT 2040
ATGTTTTATA CTCTACAGAT TTTACAAATA ATGAGGCTGT TCCTTGAAAA TGTGTTGTTG 2100
CTGTGTCCTG GAGGAGACAT GAGTTCCGAG ATGACCCAAT CTGCCTTTGA ATCTGGAGGA 2160
AATAGGCAGA AACAAAATGA CTGTAGAACT TATTCTCTGT AGGCCAAATT TCATTTCAGC 2220
CACTTCTGCA GGATCCCTAC TGCCAACCTG GAATGGAGAC TTTTATCTAC TTCTCTCTCT 2280
CTGAAGATGT CAAATCGTGG TTTAGATCAA ATATATTTCA AGCTATAAAA GCAGGAGGTT 2340
ATCTGTGCAG GGGGCTGGCA TCATGTATTT AGGGGCAAGT AATAATGGAA TGCTACTAAG 2400
ATACTCCATA TTCTTCCCCG AATCACACAG ACAGTTTCTG ACAGGCGCAA CTCCTCCATT 2460
TTCCTCCCGC AGGTGAGAAC CCTGTGGAGA TGAGTCAGTG CCATGACTGA GAAGGAACCG 2520
ACCCCTAGTT GAGAGCACCT TGCAGTTCCC CGAGAACTTT CTGATTCACA GTCTCATTTT 2580
GACAGCATGA AATGTCCTCT TGAAGCATAG CTTTTTAAAT ATCTTTTTCC TTCTACTCCT 2640
CCCTCTGACT CTAAGAATTC TCTCTTCTGG AATCGCTTGA ACCCAGGAGG CGGAGGTTGC 2700
AGTAAGCCAA GGTCATGCCA CTGCACTCTA GCCTGGGTGA CAGAGCGAGA CTCCATCTCA 2760
AAAAAAAAAA AAAAA 2775
Seq ID NO- 56 DNA Sequence
Nucleic Acid Accession ^ BC000278
Coding sequence 113 1144
1 11 21 31 41 51
I I I I I I
CTCGCCACGG CACCCAGGCT GCGCGCACGC GGTCCCGGTG TGCAGCTGGA GAGCGAGCGG 60
CCACCGGGAG CCCCCGGCAC AGCCCGCGCC CGCCCCGCAG GAGCCCGCGA AGATGCCCCG 120
GCGCAGCCTG CACGCGGCGG CCGTGCTCCT GCTGGTGATC TTAAAGGAAC AGCCTTCCAG 180 CCCGGCCCCA GTGAACGGTT CCAAGTGGAC TTATTTTGGT CCTGATGGGG AGAATAGCTG 240
GTCCAAGAAG TACCCGTCGT GTGGGGGCCT GCTGCAGTCC CCCATAGACC TGCACAGTGA 300
CATCCTCCAG TATGACGCCA GCCTCACGCC CCTCGAGTTC CAAGGCTACA ATCTGTCTGC 360
CAACAAGCAG TTTCTCCTGA CCAACAATGG CCATTCAGTG AAGCTGAACC TGCCCTCGGA 420
CATGCACATC CAGGGCCTCC AGTCTCGCTA CAGTGCCACG CAGCTGCACC TGCACTGGGG 480
GAACCCGAAT GACCCGCACG GCTCTGAGCA CACCGTCAGC GGACAGCACT TCGCCGCCGA 540
GCTGCACATT GTCCATTATA ACTCAGACCT TTATCCTGAC GCCAGCACTG CCAGCAACAA 600
GTCAGAAGGC CTCGCTGTCC TGGCTGTTCT CATTGAGATG GGCTCCTTCA ATCCGTCCTA 660
TGACAAGATC TTCAGTCACC TTCAACATGT AAAGTACAAA GGCCAGGAAG CATTCGTCCC 720
GGGATTCAAC ATTGAAGAGC TGCTTCCGGA GAGGACCGCT GAATATTACC GCTACCGGGG 780
GTCCCTGACC ACACCCCCTT GCAACCCCAC TGTGCTCTGG ACAGTTTTCC GAAACCCCGT 840
GCAAATTTCC CAGGAGCAGC TGCTGGCTTT GGAGACAGCC CTGTACTGCA CACACATGGA 900
CGACCCTTCC CCCAGAGAAA TGATCAACAA CTTCCGGCAG GTCCAGAAGT TCGATGAGAG 960
GCTGGTATAC ACCTCCTTCT CCCAAGGCAT CATCCTCTCA CTGGCCCTGG CTGGCATTCT 1020
TGGCATCTGT ATTGTGGTGG TGGTGTCCAT TTGGCTTTTC AGAAGGAAGA GTATCAAAAA 1080
AGGTGATAAC AAGGGAGTCA TTTACAAGCC AGCCACCAAG ATGGAGACTG AGGCCCACGC 1140
TTGAGGTCCC CGGAGCTCCC GGGCACATCC AGGAAGGACC TTGCTTTGGA CCCTACACAC 1200
TTCGGCTCTC TGGACACTTG CGACACCTCA AGGTGTTCTC TGTAGCTCAA TCTGCAAACA 1260
TGCCAGGCCT CAGGGATCCT CTGCTGGGTG CCTCCTTGCC TTGGGACCAT GGCCACCCCA 1320
GAGCCATCCG ATCGATGGAT GGGATGCACT CTCAGACCAA GCAGCAGGAA TTCAAAGCTG 1380
CTTGCTGTAA CTGTGTGAGA TTGTGAAGTG GTCTGAATTC TGGAATCACA AACCAAGCCA 1440
TGCTGGTGGG CCATTAATGG TTGGAAAACA CTTTCATCCG GGGCTTTGCC AGAGCGTGCT 1500
TTCAAGTGTC CTGGAAAGTC TGCTGCTTCT CCAAGCTTTC AGACAAGAAT GTGCACTCTC 1560
TGCTTAGGTT TTGCTTGGGA AACTCAACTT CTTTCCTCTG GAGACGGGGC ATCTCCCTCT 1620
GATTTCCTTC TGCTATGACA AAACCTTTAA TCTGCACCTT ACAACTCGGG GACAAATGGG 1680
GACAGGAAGG ATCAAGTTGT AAAAAAAAAA AAAAAAAA 1718
Seq ID NO: 57 DNA Sequence
Nucleic Acid Accession tt : NM_006632.1
Coding sequence: 377..1582
1 11 21 31 41 51
I I I I I I
ACGCGTCCGC CCACGCGTCC GCCCACGCGT CCGGTCGGGG CCAGAGCGCA GGTGTACCTG 60
GCGGCCGTGC TGGAGCACCT GACCGCCGAG ATCCTGGAGC TGGCTGGCAA CCCGGCCCGC 120
GACAAGAAGA CCCGCATCAT CCTGCGCCAC CTGTAGCTGG CCATTCGCAA CGGCGAGGAG 180
CTTAACAAGC TGCTGGGCGA AGTCACCATC GCGCAGGGCG GTGTCCTGCC CAACATTCAG 240
GGCGTGCTTC TGCCCCAGAA GACCAAGAGC CACCACAAGG CCAAGGGTGA AAACCATTCA 300
CTAGGAGAGG AGAAACACAA TGGCCACCAA GACAGAGTTG AGTCCCACAG CAAGGGAGAG 360
CAAGAACGCA CAAGATATGC AAGTGGATGA GACACTGATC CCCAGGAAAG GTCCAAGTTT 420
ATGTTCTGCT CGCTATGGAA TAGCCCTCGT CTTACATTTC TGCAATTTCA CAACGATAGC 480
ACAAAATGTC ATCATGAACA TCACCATGGT AGCCATGGTC AACAGCACAA GCCCTCAATC 540
CCAGCTCAAT GATTCCTCTG AGGTGCTGCC TGTTGACTCA TTTGGTGGCC TAAGTAAAGC 600
CCCAAAGAGT CTTCCTGCAA AGTCCTCAAT ACTTGGGGGT CAGTTTGCAA TTTGGGAAAA 660
GTGGGGCCCT CCACAAGAAC GAAGCAGACT CTGCAGCATT GCTTTATCAG GAATGTTACT 720
GGGATGCTTT ACTGCCATCC TCATAGGTGG CTTCATTAGT GAAACCCTTG GGTGGCCCTT 780
TGTCTTCTAT ATCTTTGGAG GTGTTGGCTG TGTCTGCTGC CTTCTCTGGT TTGTTGTGAT 840
TTATGATGAC CCCTTTTCCT ATCCATGGAT AAGCACCTCA GAAAAAGAAT ACATCATATC 900
CTCCTTGAAA CAACAGGTCG GGTCTTCTAA GCAGCCTCTT CCCATCAAAG CTATGCTCAG 960
ATCTCTACCC ATTTGGTCCA TATGTTTAGG CTGTTTCAGC CATCAATGGT TAGTTAGCAC 1020
AATGGTTGTA TACATACCAA CTTACATCAG CTCTGTGTAC CATGTTAACA TCAGAGACAA 1080
TGGACTTCTA TCTGCCCTTC CTTTTATTGT TGCCTGGGTC ATAGGCATGG TGGGAGGCTA 1140
TCTGGCAGAT TTCCTTCTAA CCAAAAAGTT TAGACTCATC ACTGTGAGGA AAATTGCCAC 1200
AATTTTAGGA AGTCTCCCCT CTTCAGCACT CATTGTGTCT CTGCCTTACC TCAATTCCGG 1260
CTATATCACA GCAACTGCCT TGCTGACGCT CTCTTGCGGA TTAAGCACAT TGTGTCAGTC 1320
AGGGATTTAT ATCAATGTCT TAGATATTGC TCCAAGGTAT TCCAGTTTTC TCATGGGAGC 1380
ATCAAGAGGA TTTTCGAGCA TAGCACCTGT CATTGTACCC ACTGTCAGCG GATTTCTTCT 1440
TAGTCAGGAC CCTGAGTTTG GGTGGAGGAA TGTCTTCTTC TTGCTGTTTG CCGTTAACCT 1500
GTTAGGACTA CTCTTCTACC TCATATTTGG AGAAGCAGAT GTCCAAGAAT GGGCTAAAGA 1560
GAGAAAACTC ACTCGTTTAT GAAGTTATCC CACCTTGGAT GGAAAAGTCA TTAGGCACCG 1620
TATTGCATAA AATAGAAGGC TTCCGTGATG AAAATACCAG TGAAAAGATT TTTTTTTCCT 1680
GTGGCTCTTT TCAATTATGA GATCAGTTCA TTATTTTATT CAGACTTTTT TTTGAGAGAA 1740
ATGTAAGATG AATAAAAATT CAAATAAAAT GATAACTAAG AAAAAAAAAA AAAAA 1 95
Seq ID NO: 58 DNA Sequence Nucleic Acid Accession tt ■ NM_ Coding sequence: 145..1812 1 11 21
GGCCCTGCCC TGAAGGCTGG TCACTTGCAG AGGTAAACTC CCCTCTTTGA CTTCTGGCCA 60
GGGTTTGTGC TGAGCTGGCT GCAGCCGCTC TCAGCCTCGC TCCGGGCACG TCGGGCAGCC 120
TCGGGCCCTC CTGCCTGCAG GATCATGCCC ACCACCGTGG ACGATGTCCT GGAGCATGGA 180
GGGGAGTTTC ACTTTTTCCA GAAGCAAATG TTTTTCCTCT TGGCTCTGCT CTCGGCTACC 240
TTCGCGCCCA TCTACGTGGG CATCGTCTTC CTGGGCTTCA CCCCTGACCA CCGCTGCCGG 300
AGCCCCGGAG TGGCCGAGCT GAGTCTGCGC TGCGGCTGGA GTCCTGCAGA GGAACTGAAC 360
TACACGGTGC CGGGCCCAGG ACCTGCGGGC GAAGCCTCCC CAAGACAGTG TAGGCGCTAC 420
GAGGTGGACT GGAACCAGAG CACCTTTGAC TGCGTGGACC CCCTGGCCAG CCTGGACACC 480
AACAGGAGCC GCCTGCCACT GGGCCCCTGC CGGGACGGCT GGGTGTACGA GACGCCTGGC 540
TCGTCCATCG TCACCGAGTT TAACCTGGTA TGTGCCAACT CCTGGATGTT GGACCTATTC 600
CAGTCATCAG TGAATGTAGG ATTCTTTATT GGCTCTATGA GTATCGGCTA CATAGCAGAC 660
AGGTTTGGCC GTAAGCTCTG CCTCCTAACT ACAGTCCTCA TAAATGCTGC AGCTGGAGTT 720
CTCATGGCCA TTTCCCCAAC CTATACGTGG ATGTTAATTT TTCGCTTAAT CCAAGGACTG 780
GTCAGCAAAG CAGGCTGGTT AATAGGCTAC ATCCTGATTA CAGAATTTGT TGGGCGGAGA 840
TATCGGAGAA CAGTGGGGAT TTTTTACCAA GTTGCCTATA CAGTTGGGCT CCTGGTGCTA 900
GCTGGGGTGG CTTACGCACT TCCTCACTGG AGGTGGTTGC AGTTCACAGT TGCTCTGCCC 960 AACTTCTTCT TCTTGCTCTA TTACTGGTGC ATACCTGAGT CTCCCAGGTG GCTGATCTCC 1020
CAGAATAAGA ATGCTGAAGC CATGAGAATC ATTAAGCACA TCGCAAAGAA AAATGGAAAA 1080
TCTCTACCCG CCTCCCTTCA GCGCCTGAGA CTTGAAGAGG AAACTGGCAA GAAATTGAAC 1140
CCTTCATTTC TTGACTTGGT CAGAACTCCT CAGATAAGGA AACATACTAT GATATTGATG 1200
TACAACTGGT TCACGAGCTC TGTGCTCTAC CAGGGCCTCA TCATGCACAT GGGCCTTGCA 1260
GGTGACAATA TCTACCTGGA TTTCTTCTAC TCTGCCCTGG TTGAATTCCC AGCTGCCTTC 1320
ATGATCATCC TCACCATCGA CCGCATCGGA CGCCGTTACC CTTGGGCTGC ATCAAATATG 1380
GTTGCAGGGG CAGCCTGTCT GGCCTCAGTT TTTATACCTG GTGATCTACA ATGGCTAAAA 1440
ATTATTATCT CATGCTTGGG AAGAATGGGG ATCACAATGG CCTATGAGAT AGTCTGCCTG 1500
10 GTCAATGCTG AGCTGTACCC CACATTCATT AGGAATCTTG GCGTCCACAT CTGTTCCTCA 1560
ATGTGTGACA TTGGTGGCAT CATCACGCCA TTCCTGGTCT ACCGGCTCAC TAACATCTGG 1620
CTTGAGCTCC CGCTGATGGT TTTCGGCGTA CTTGGCTTGG TTGCTGGAGG TCTGGTGCTG 1680
TTGCTTCCAG AAACTAAAGG GAAAGCTTTG CCTGAGACCA TCGAGGAAGC CGAAAATATG 1740
CAAAGACCAA GAAAAAATAA AGAAAAGATG ATTTACCTCC AAGTTCAGAA ACTAGACATT 1800
15 CCATTGAACT AAGAAGAGAG ACCGTTGCTG CTGTCATGAC CTAGCTTTGA TGGCAGCAAG 1860
ACCAAAAGTA GAAATCCCTG CACTCATCAC AAAGCCCATA CAACTCAACC AAACTTACCC 1920
CTGAGCCCTA TCAACCTAGG TCTACAGCCA GTGGAGTCTA TTGTACACTG TGGAAAAATA 1980
CCCATGGGAC CAGATCCTGC CAAATTCTTC CAGCTCACTT TATTCTCAGC ATTCCTAGGA 2040
CATTGGACAT TGGTTTTCTG GAGGGTTTTT TTTCCGATCT TTGTATTTTT TTAAATTTGA 2100
20 TTCTTTTCTT TGCAATGCTA GCAACCAGAA TACATAGGGG AACTGTGGGC TAGGCAAANA 2160
AAATAGAAAA AGTGTGAAAA ACAGTAAAGT TGGGAGAGGA GCATCTATTT TCTTAAAGAA 2220
ATAAAACACC NAAAACAAAA AAAAAAAAAA AAAAAAA 2257
Seq ID NO: 59 DNA Sequence 2.D Nucleic Acid Accession tt : Eos sequence
Coding sequence: 227..2311 1 11 21 31 41 51
I I I I I I
GTCAGGGGCG TGTTGGCCCC GCACAGATTG AGCCGAGTTG TCGCCCCGCT GGGAGAAGTG 60
30 ACCCTCCTGC GCCTGATCAG AACACTGAGG CTCAGAGAAG TTAACTACTC CAAAGTCATA 120
TAGCCAGTAT TTTCTGGAGC TGTAATTCAA ATCAGATGTG TTCAATACCT TCTACTACCC 180
CATTGCTGTC TTTATGAAAA GAAATTTCAT TTCAATATAG GTGACTATGC AGCCTGCAAT 240
TCAAGTATGG TTTGGAGAAG ATCTGCCTCT AAGTCCTCGG AGTCCTCTGA CTCCCAGACA 300
CGGACCAGGA TTGGCTAATG TTTGTCAGTA CGATGAGTGG ATAGCTGTGA GGCATGAAGC 360
35 CACTTTGTTG CCCATGCAAG AAGATCTGTC AATCTGGTTA TCTGGTTTAT TAGGTATTAA 420
AGTTAAGGCA GAAAAATTAT TGGAAGAACT TGATAATGGA GTACTATTAT GTCAACTGAT 480
TGATGTTCTT CAAAACATGG TGAAAACATG CAACTCTGAA GAATCAGGGA ATTTTCCAAT 540
GAGAAAAGTG CCCTGTAAGA AAGATGCTGC ATCAGGTTCA TTCTTTGCTC GGGACAATAC 600
CGCAAACTTC CTTCACTGGT GTAGGGACAT TGGGGTTGAT GAAACTTACC TCTTTGAATC 660
40 TGAAGGTTTA GTTTTGCACA AAGATCCAAG ACAGGTGTAT CTTTGTCTTC TTGAAATTGG 720
TCGAATTGTG TCAAGATACG GGGTTGAGCC ACCAGTGTTA GTAAAACTTG AGAAAGAAAT 780
TGAGTTAGAA GAGACTTTGC TTAATACTTC TGGGCCTGAA GATTCCATCA GCATTCCAAA 840
ATCATGCTGT CGGCATGAAG AGCTACATGA AGCTGTTAAA CATATTGCTG AGGACCCTCC 900
TTGTAGTTGT TCTCATCGAT TTTCTATTGA GTATTTATCT GAAGGACGGT ACCGACTAGG 960
45 GGATAAAATA CTCTTTATAA GAATGCTTCA TGGAAAACAT GTCATGGTTC GCGTTGGTGG 1020
AGGCTGGGAT ACTCTTCAAG GATTTTTGCT TAAATATGAC CCCTGTCGAA TATTACAGTT 1080
TGCCACATTA GAACAAAAAA TTTTAGCATT TCAAAAAGGA GTTTCTAATG AAAGTGTACC 1140
TGATTCGCCT GCCAGAACAC CTCAGCCTCC TGAAATGAAT CCTTTGTCAG CAGTTAACAT 1200
GTTTCAGAAA CAAAATTCAA AACCCAGCGT GCCAGTTAGT ATTCCAAAAA GCAAAGAAAA 1260
50 ACAGGGACGT CCACCAGGTG CATTGGTGCC AGCATCTTCA CTGAAAGGAG GTAATCTGGG 1320
CTCTATGTCA GTCCGTTCTA AATTGCCAAA TTCTCCAGCA GCATCTTCTC ATCCCAAGCT 1380
CAAGTCTTCA AAAGGCATAA CGAAGAAACC GCAGGCTCCT TCAAACAATG CATCATCTTC 1440
ACTTGCTTCA TTAAATCCAG TAGGTAAAAA CACTTCTTCA CCAGCTTTAC CAAGAACTGC 1500
ACCTTGTATA TCTGAGTCAC CGAGAAAATG TATTTCATCC CCCAATACCC CCAAGGCCAA 1560
55 GGTTATTCCA GCCCAGAATT CAGCAGATCT GCCCGAGTCC ACACTTTTGC CAAATAAGTG 1620
TTCAGGAAAA ACTCAACCTA AGTATTTGAA ACATAATCAT ATTTCTTCCA GAGATAATGC 1680
AGTATCTCAC TTAGCTGCAC ATTCAAATTC ATCCTCAAAA TGTCCCAAGC TGCCTAAAGC 1740
AAATATACCT GTAAGACCTA AACCTTCTTT CCAGTCCTCT GCAAAAATGA CAAAAACCAG 1800
TTCCAAAACC ATAGCCACGG GTCTAGGAAC ACAGTCTCAA CCATCCGATG GAGCCCCACA 1860
60 AGCAAAGCCA GTCCCAGCAC AGAAACTTAA ATCGGCCTTG AATTTAAATC AGCCAGTTTC 1920
TGTGTCCTCA GTTTCTCCTG TAAAAGCCAC ACAGAAATCA AAAGATAAGA ATATAGTTTC 1980
AGCTACCAAA AAGCAGCCTC AGAATAAAAG TGCATTTCAG AAGACAGGAC CCAGCTCCTT 2040
GAAGTCTCCT GGCCGTACCC CACTGTCCAT CGTGAGCCTA CCCCAGTCTT CTACCAAAAC 2100
ACAAACTGCA CCGAAGTCAG CACAGACTGT CGCTAAGAGC CAGCATTCAA CTAAAGGGCC 2160
65 TCCCAGAAGT GGCAAAACCC CAGCTTCAAT CAGGAAACCA CCCTCATCTG TTAAGGATGC 2220
AGATAGTGGA GATAAAAAAC CTACTGCAAA GAAAAAGGAA GATGATGACC ATTATTTTGT 2280
CATGACTGGA AGTAAGAAAC CTAGAAAATA AATACATACT CATTATAAAA AAAGAGAAAA 2340
GGAAGAATGA ATGTGTTAGC TTCACATCTT AAAAGTTTCT CCTATTTGTG TCTGTCTAAA 2400 TAGGTGCAGA CACTAAGGAT AGTGAGGATG GAGGCTGGGA TGAGGAAAGG GTTCATCAGA 2 60
70 ATTCACATAT CTGAATTCAC TGGAAAGAGC CCTTCTGAAG CAAACAGTTG TAAAATCACT 2520 GCAAGGTTTT TATTAATAAT AGACATGTAT ATGATTTTCA GTCTATAGCA TCTTTGTTAA 2580 CATCTGCCTT TTGCAGGAAA TGTAAAAGTT ATTTAACACT ACAAGAATTT TAACAATAGT 2640 TGCTCTATTT TTGAATATGT ATTAAATATG GAGTTCATAT ACCTGCTAAT ATCAACGGTG 2700 GTGCTCTTAC TATTAGTTAA TTGCATTTTG GTTAAAAAAA AAAAAGCAAC AGTTTGGCAC 2760
75 TTGTCCTACA AAAGGCACCT AATTTAATTT TCTGATCAGG ATTGCCTGAT CCAACAGTGC 2820 TAAGTCATGG CTGCTGCTGA CTAGCTTGGC ATTATTCTGT GTTAGGTAGA ATTCTTATTA 2880 TTTATTTTTT TAAGCTTTCC AAATTGGAAG GAACTGATTG TTTCATGTGG CTTATATTTA 2940 CATTGGTAAT ATTTTGTCAC CAATATTTTT GGTTAAAAAA AATCCAACAA ATTAACTTAC 3000 TGAAATATAA ACAAATTTTG TAAACAATTT TTTATATTAT CTATAAAAAC GTAGACACCT 3060
80 TATGTTTCAC ATGTTGTGCA ATGTGACAGG GGAAGCTGAT TTAGTAGCTT TTAGCATATT 3120 AAAAATAATT TTTTATAATG TAATTTCCTG TGAGTGCAGA CCTGACATTT TACATTAAAA 3180 TAATGTGAAA CATCAGAATT ATGTTTTAAC AACTTTAAAA TTAAGATGAT GTTAAAATAA 3240 TTTTAGAGTT ATGCTATGGA AAAATTCTAT CATGAAATTA TTTTTCTCTA GATAGCACAA 3300 TACCAATTTT AATTAATTTC TTCCAATTAG GTTACTTTTC TTTAATAAAG TTATGCTGCC 3360 TTCAGTTTTC CAATGGCAAG TAGACAGGAT ATGTTCAAGG TTTTCTGCAC TGTAGGCACA 3420
GTCTCTCAAG CATATCCTGA TCATGTAATG ACTGCATAAA CTCCATCAAC CTAAGGTGAT 3480
ACTTGTAAAT AATTTATTTT TAAGGGATGG TGACTTTAAA AATTATTAAT GAACTTTGAG 3540
AAGTTTTAAG AGTGCTTTTA AAACTTCACA GTATTGCCAA TTATCTTAGG TTATTCAGTA 3600
TTCAGGTTTG TGTTTCTCTG TTTTAAACTA AAATGTGTTT TCTGAAGAAA AAAATAATAG 3660
TTTACACAAA TGTACAATCA TAGAATAAGC ATTTTAAGCT GGCGACTAGT GTTCTATAGA 3720
TTACAAAGCA AGAAAACTTT CTATGAAGAT AAATGACCTT TTGCCTGAAG AGTACAGATA 3780
AAATCAAAGA TGTGTGCAAG CTAGTTTTTG GAAGAAGTGA TGCTTCTCTT CTTTAAAGAG 3840
ACAGTCACCA AATACTTGGT TTAACTCGAC TATTGACTTG GGCATTGAGA GAGATGATAT 3900
ATACATCTTT GGAAAGTGAA GTCAATGTTC AAGAGGTGAT AGAAGCTTTA CTTTTTAGTG 3960
ATCAGAAATA TTTAGTGCAT CTTTTCAGAC AGGAAGAATT TTATCATCAA GTATTCCCTT 4020
ATAAAACCAA GTAACACTTC TTTATCAGTA ACTTTTAGAA CTTAAAAGAA AGCAAAAAGT 4080
AAATGGAATT GTAGGCAATT TATGAATCCT AGTAGATTTT ACAATATGTA ATTTATGTTG 4140
TTTACAGTAT ATAAACACTA AGTTTTGTGT TAAATGTGAT CAGGAATAAA AGTATCCCAC 4200
AGGCATCTGA CACAAATTCC AGAATTAGCC AAAGAATTGT TTATTTGAGG CCAGGCAATC 4260
CCAGCATTTT GGGAAGCCAA GTTGGGCAGA TCACGAAGTC AGGAGTTCGA AATCAGCCTG 4320
ACCAACATGG TGAAACCTCT TCTCTACTAA AAATACAAAA TTAGCCGGGC ATGGTGGCAC 4380
ATGCCTATAA TCTCAGCTAC TCAGGAGGCT GAGGCAGGAG GATCGCTTGA ACCCGGGAGG 4440
CAGAGGTTGC AGTGAGCCAA GATTGCGCCA CTGCACTCCA GCCTGGGCAA CAGAGTGAGA 4500
CTCTGTCTCA AAAAAAAAAA AAAAGAAAAA GAAAAGAAAA AGGTTTATTT GAATAATTGG 4560
AAGTCAGTTT ATACATTACT ATTTTTCAGC AGTAGGGAAT TTCTCCAATT ACATTCATGT 4620
TGAATGAATT TTTATTTATA TATAGCTTAC CCTTCCAAAA TAAAAGTGTT TTTTTAATGT 4680
TGTTTTGTTT TGTTTTGTTT TTTTCCTTTT TTGAGACGGA GTTTCACTCT TGTTGCCCAG 4740
ACTGGAGTGC AGTGGCACAA TCTCAGCTCA TTGCAACCTC TGCCTCCTGG GTTCAAGTGA 4800
TTCTGCTGCC TCAGCCTCCT GAGTGGTTGG GATTACAGGC ATCCACCACC AGGCCCAGCT 4860
AATTTTTTTG TATTTTCAGT AGAGATGGGG GTTTCACCAT GTCGGCCAGG CTGATCTCAA 4920
ACTCCTGACC TCAGGTGATC CACCTGCCTC AGCCTCCCAA AGCGCTGGGA TTACAGGCAT 4980
GAGCCATCAC ACCCAGCGAA AAGTTTTGTT TGAATAAACA ATATCCGAAA GACAATTAGT 5040
TTCTTCAGAT GTATTTTGAA ATTCTCCTAA AGAGCTAGTG TTTCTATTCA TTTTCACAAT 5100
TTAAAAACAG CTCTTAACAT TGCTGAAGTT GGGAGAACTT TCCATCTCTT CTTAATAACA 5160
GTGCAAGATT TTGTAAATTC TTTTTTGTGT TTAATGTTTA ATAAAACGAG TATTAAGCTT 5220
AAATTACTGA AGTACCTGGG AGAAGTAATG ATGTGTACTT TCAAAAAAAT GGAAAATGCT 5280
TTTATTTTAT TTTCTATAAT TTGTTAACAT GATATGTAAA ATTAAACTTC GGAGCACAAT 5340
GAAATGCCGA TTATTTTTAC CTTGTTTGGG CTTAAAGTAG GTATTTAAGG TTTATGTGTT 5400
CAAAATGCCT TGGTAAATTG GATGACCTCT AACTTTACTG TCCATATGGA GTTTGTCATT 5460
CTTTATGGAT AAGAGAACTT AAGGAAAAGT TACTGTTTTT CTTCAGTCTT TTTATATCTA SS20
TCTGATTTAA AATCTGTTAC TTTATTAAAA GGCTTCAACA ACAGGTTGTT AGGATGTAGT SS80
CTTACATCCA GGTTCACATA ATAACCCCAT TTGAATCCAA ATTTGTGTAT ATTTTCTTAT 5640
GCCAGCAGTA TTTGTATCCA ATTTTAACTT AGGTTTGTTT TCTTGAG 5687
Seq ID NO 60 DNA Sequence
Nucleic Acid Accession tt Eos sequence
1 11 21 31 41 51
I I I I I I τττττττττ-r TTTTTTTAAA TCACAACACC TCTGAATATG TTTAATGACA GAGCAATTAG 60
AAACAAAAGT TTAATTTTAT ACATCATAGA ATTACTATTT AGAAACAAAT AGGACATGTT 120
AGAAGTAAGA AAAAATAAAA CACTTTGTTG AAGTTATATA CCTATTTGGA TTTTTTTAAA 180
AGCATTACCC AATAGGCTAT AGAACGATGC CAACACATAA TGCCAGGTTG CAAGGCATGG 240
AGAATGGGAG AATGTGACAT GACTGTCTAA TGGGTATAAA GCTCCCTTTT GAAGTGAAAA 300
AATTACTTTG GATCTAGATA GTAGTGGTAC TGGCAAATGT GCTAAACGCC AATGAATAAT 360
GCACATTAAA TGGTTTAATT GTATAATTTT GTGGTGTAAA ATTCCTATAT CAATTATTCT 420
TTAAATAAAC AAGTGGCTGA CCAGATTTGA CCAAGAGACC ATAGTTTGTC AGCCCTTGGT 480
TTATGCTACA AATTTAATTC CCATATGCTT GAAATAGTAA ATGCTGTCAT TTTAATCATT 540
TACATTAGAA ACATGGGATG TTTTGAAACT ATAATATGTT ATGCAATTAT ATGAACACTA 600
AAATTATTAC TGTGGAATTT TTTTATTTGT AGTAACGGGA GTATGCAATT TTATTTTGCT 660
GTACACA 667
Seq ID NO 61 DNA Sequence
Nucleic Acid Accession it Eos sequence
1 11 21 31 41 51
I I I I I I
GACCTAAGAA CTTATCAAAG AACTCAGCAG TATGAGAATA GATCAATACA TAGAGGGTTT 60
CCTTTAAGTC TTGTAGAAAC TCATTACTCT CCAGTCTCTT TTTCCACTTA TAGTAGAGAG 120
AATCAGACTT GCGGATATCC AGTTAACTAT CAATACCTTT AAAAAATGTG AACAAGCAGT 180
CCATCTGAAT AATTATACCA AATGTCAAGG CTTTTAAAAG TGCTTAACTT TAAAGGTCCT 240
TTGCAGTTGT TCAGACCTAG ATTCTCAGTT CAGTTAGCAC AGAGAGAGAC AAGGAAAAAA 300
TGAGGAACAC TTTTCTCACG CATAAATATT CACTGGTTTT TGAAATACTA TTGATTCCTT 360
GGATAAGAAA A AGGTCAAC TTTATAGCTT TTTGTCTCGA AATTGATTTG CCGCCACAGA 420
CAGTGGCTTG GTGCCTATAA TCCCAGCCTA CATGGGAGGC TGAGGTGGGA GATCGCTTGA 480
GCCCAAAAAG TCAGAGGTGC AGTGAGCTGT GATTGTGCCA CTGTATCCCA ACCTCAT 537
Seq ID NO 62 DNA Sequence
Nucleic Acid Accession # Eos sequence
1 11 21 31 41 51 i i i i i i
TTTTTTTTTT TTTTAATTTT AATAAGTTAA ATTTTTAATA ATTGATTTAT TTATACTCCA 60
AAGGATACAA CATGCAAAAT GTCTACCCAC TCCAGCTACC ATCAGTTCAG CATTTATAAC 120
TACTATCAAT AATGTTTTCA TGTAAGACAG CCATCACCTA AAGGAATACT TTTAAAACAG 180 GTTGTACAAT AAAACAGGTT GGACCAATAT AAAAGAAATA TAAAATAAGG TGGTTTATTT 240 AAATGTAAAT ACACAGATAC TTCCATTAAA TCTAAACAAA CTTTAAAAAG AGGAGCAAAT 300
AATGAGTAAT GCCATAGAAC ATTAGAAGAA CACAGTTAAC GAATGGAAAC TTGTAACACG 360
ATACACACAC ACGCATGCAT ATATATATGT ATCATATATA TCAACTAAAA GACATTTTCT 420
TAGAGCATAT TGAATTGTTA ATAATTATTT GAAGTGACAT GTGGTGGGAC ATAAATCAAG 480
ACTCAGTAAA TTTGAAAAGA TTCAATATCA TAAAGAATAT ATGATCCAGC CTTAGTAGAA 540 GTAAGGGAAA TTTAAAAAAT GTAACTAAAA TATCTTTAAT TTTGGAAATT AAGAAAATAC 600
ACTTCAAAAA AATTTAAAGT CCTGCCTCAG CCTCCCCAGT AGCTGGGATT ACAAGCATGC 660
ACCACCATGT CCAGCCAATT TTGTAATTAT AGTAGAGACA GG 702 Seq ID NO : 63 DNA Sequence
Nucleic Acid Accession tt : AK025967
1 11 21 31 41 51
I I I I I I
ACAACAGGAA CACATATAGC TGGAATGCAG ATGGGATCTG TGCTACTTAC GCTAGCCATG 60 GGATGATTAG AACAAGATAA GAGACATGAG GAAGACTTCT TCAAGGAGGT GCTCAAGCCA 120
TGTTTTGGAA AAGAGAACTC AAGGTCTGGC AGGGAGAAAG GAGCAAGGTC CTCTTCTCCC 180
TGAAGGCTGT CACAGTTCCT GTGCAGAGAG AGAGGGCACT GCAGCACCCA GGCGCTGACT 240
GCCTTTTGTC AGTCTCATTT GCAGGCCCCC AGCTGGAGAA CCCAGGAGGA AGAGGAAAAA 300
AGTTTTTTCC TCCTCTACAC TCCCCATGCA TGACTAAAGA GTAGGAGGAG TCAGCAAGGC 360 AGACATATAT AGTACCCAGG AGGTGGACAA ACAACTGCCT TGGTGGAAAC TCTGTCCTTT 420
CTGGACTTAT CCTGGTGCCA CTGAGACTGT GCAGATTTAG ATCTACAATC CACCTGGAAT 480
TGATTTTTGT ATATGGAGTG AGGTCCCACA CTTACAGGGA AAGCATCACC CGAAAGTGAG 540
AATGCCTAGA GGCAGGAATC ATGGAGGCTT CCTTAACCGT CTGTCTGCAA CAGCAGGTGC 600
TAGAGATGAC ACTGCAGAGT AGAGAACAAA GGAATCTTAG TAATTGTTCA ATCCAATCTC 660 CACACTTTAA AGATGAAGAA ACTGGTATTG AGAAAAATAC ACAGCTTATC CAAGGTTGCA 720
CTGCTGGTTG GTAGCTGAGA TGAATTTAGA ACCCACATCT GATGACTACA CCATATTGCT 780
CCCAGTTTTC CTGTCTGTTC CACATGTAAA AGTCTGACTC TTCACTTCTC CTTTGAGTAT 840
ATAGACTTTT AACATTTTTG TATGTCAAGA TGGACTTTTC CTCATACCCA GCCCCTGCCT 900
TTTCTCCTCC CTTCATACCT TGCAGGATCT TTAACAGAAT TTAAAAGGAG TTTTTTGTTT 960 TGTTTTGATG TATCTAA AA AAGTCAAGGG AGGGAGAGGG CCAGTATAAG CAAGAGTACA 1020
GTTTCCTAGT TTGTAGATGC GGTAGTCTGA GGAATCAGAA ACACACAAAG GTTTGGAGAA 1080
CTGGTACATG CTCCCAGGTG GGAAGCCAGG ACTCTTGGTA GGATCTTGAG GACAAGGCAA 1140
AGGACAATAA GAGAGCGAGG GGATCCTAGA GGTGGAATCA AGGAAGAGAA ACTAGAGAGA 1200
GAAAAAGGAA CTGGCTATCC ATCCATGATG GATCCTGTGT GGACTGATGG GTGGCTTGGC 1260 ATCATCCTTT AGTAGACTTC ATGTGGTTGA ATAATTGGCC AATGGAAGGA ATTTCTTTTT 1320
TGGTAACAGA CTCTGTGTGT ACAGTTATGG GTCTTAATTT ATAATAAAAG GTTACATTGA 1380
AAATTGAAAA AAAAAAAA 1398
Seq ID NO: 64 DNA Sequence
Nucleic Acid Accession It : Eos sequence
1 11 21 31 41 51
I I I I I I
GGCACGAGGA GAGAAACTCC ATCTCAAAAA CAAAACAACA CAAAACAAAA AAAGAAGAGA 60
AATCAAAGCT TGTTCCCTGT CTCTCTCTCT CCACATGTGA GCACACAAAG AGGTCACGTG 120
AACACACAAT GAGAAGGAGG CTGCCTGCAA GTT AGAGAA GAGGCCTCAG CATGAAACCT 180
GCCTTACTGG CACTTTGGTC TTGAACTTCC CAGCCTCTAA AACTGTGAGA AATAAGTTTC 240
TGTTGTTCAA GCCACCCAGT CTATGGTATT CTGTATGGCA GCCAGAATTA AGACACCAGT 300
GAAGCAAGAT AATCAGTAAC TGGATACTTA ACTGTGTGGT ATAAAACATA GGGGCTTTAG 360
TAGAGAAGAA AATTGGACTT TGTTGGGGAC ATCCTTACTA CTTCTGCTCA TGTATCATGC 420
TTTAGCTTGT TTCTGTCTTT GGAGGAGGCT GCATATTTTT AAAATACCCC CAAAAGTACA 480
AAGACTAATG TTATAGCCCC TGTGTTCTCA TTATCCAGGC TTAATAAATG TTGGCCATTT 540
TCCACTTTTG TTTCATATAT AAGTTTCTAC AAAATGACAA CACCTTAGAT AAAGCTGAAG 600
TTCATGTTTC ATTCTGCATC CCTTCCCCCA AGGGCTTCTT TTGCTCAATA TGGGACTCAT 660
GAGAGTCATC GGTGTTGTGT GAGGCAGCTG TTTGTTGATT TTCTGGACCA AATAATGTTC 720
CACCGTGTGA CTGGACATAC CTTAGTCTAT CCATTCTACC ACTGATGAGC ATGTAAGCTG 780
TTACTATTTT TAACTATTAC AAATTATCTT GCTAACACAT TTTTGTGCAT GTCTTTTGGT 840
GACCAAATGG ACTCATTTCT CTCAGGTATG TATCTCAGAG TGAAACTGTT TTATCACAGT 900
GTATGCTTTA TATTTAGTGC TTTCCAATTC CTGATTAAGA AATCTTTGCC TGCTCCTAAG 960
GATGTAAAAT TATTCTCTTA TGGCCTGGCT CAGTGGCTCA TGCCTGTAAT CCCAGCATTT 1020
TGGGAGGCCA AGGTGGGAGG ATTGCTTGAG GCCAGGAGTT CAAGACCAGC CTGGGCAACA 1080
TACTGAGACC CTCATCTCTA CAAAAAAAAA AAATTTGTTT AATTAGCTGA GCTTGGTGGT 1140
ATGCACCTAT AGTCCTAGCT ACTCAGGAGG CTGAGGCAGG AGGATCGCTT GAGCCCAGGA 1200
ATTCAGAGAT GCAGTAAGCT ATGATCATGC CACTGTATTA CAGCCTGGGT GATAGGGTGA 1260
GACCCTGTCT CTAAAAAGAT ACATCTATTA AAAATAA AT TATTTTATTT TATTTTATTT 1320
TATTTTATTA TTATACTTTA AGTTTTAGGG TACATGTGCA CATTGTGCAG GTTAGTTACA 1380
TATGTATACA TGTGCCATGC TGGTGCACTG CACCCACTAA CTCGTCATCT AGCATTAGGT 1440
ATATCTCCCA GTGCTATCCC TCCCCCCTCC CCCGACCCCA CAACAGTCCC CAGAGTGTGA 1500
TGTTCCCCTT CCTGTGTCCA TGTGATCTCA TTGTTCAATT CCCACCTATG AGTGAGAATA 1560
TGCGGTGTTT GGTTTTTTGT TCTTGCGATA GTTTACTGAG AATGATGATT TCCAATTTCA 1620
TCCATGTCCC TACAAAGGAC ATGAACTCAT CATTTTTTAT GGCTGCATAG TAAAAATACA 1680
TTTTAAAAAA TAATAAATTA TTCTCTTATG TTATTGTCTA GAATCTTCAT TATTTTACCT 1740
TTCAGATTTA GATCTACAAT CCACCTGGAA TTGATTTTTG TATATGGAGT GAGGTCCCAC 1800
ACTTACAGGG AAAGCATCAC CCGAAAGTGA GAATGCCTAG AGGCAGGAAT CATGGAGGCT 1860
TCCTTAACCG TCTGTCTGCA ACAGCAGGTG CTAGAGATGA CACTGCAGAG TAGAGAACAA 1920
AGGAATCTTA GTAATTGTTC AATCCAATCT CCACACTTTA AAGATGAAGA AACTGGTATT 1980
GAGAAAAATA CACAGCTTAT CCAAGGTTGC ACTGCTGGTT GGTAGCTGAG ATGAATTTAG 2040
AACCCACATC TGATGACTAC ACCATATTGC TCCCAGTTTT CCTGTCTGTT CCACATGTAA 2100
AAGTCTGACT CTTCACTTCT CCTTTGAGTA TATAGACTTT TAACATTTTT GTATGTCAAG 2160
ATGGACTTTT CCTCATACCC AGCCCCTGCC TTTTCTCCTC CCTTCATACC TTGCAGGATC 2220
TTTAACAGAA TTTAAAAGGA GTTTTTTGTT TTGTTTTGAT GTATCTAATA AAAGTCAAGG 2280
GAGGGAGAGG GCCAGTATAA GCAAGAGTAC AGTTTCCTAG TTTGTAGATG CGGTAGTCTG 2340
AGGAATCAGA AACACACAAA GGTTTGGAGA ACTGGTACAT GCTCCCAGGT GGGAAGCCAG 2400
GACTCTTGGT AGGATCTTGA GGACAAGGCA AAGGACAATA AGAGAGCGAG GGGATCCTAG 2460
AGGTGGAATC AAGGAAGAGA AACTAGAGAG AGAAAAAGGA ACTGGCTATC CATCCATGAT 2520
GGATCCTGTG TGGACTGATG GGTGGCTTGG CATCATCCTT TAGTAGACTT CATGTGGTTG 2580
AATAATTGGC CAATGGAAGG AATTTCTTTT TTGGTAACAG ACTCTGTGTG TACAGTTATG 2640
GGTCTTAATT TATAATAAAA GGTTACATTG AAAATTGAAA AAAAAAAAAA AAAAAAAAAA 2700
GCATTATAAG TGTACTTCTA GCCTTACTTC GTCGGGGTAA TTCGATCTCG CTCTTGCTGG 2760
CTG 2763 Seq ID NO 65 DNA Sequence
Nucleic Acid Accession it Eos sequence
Coding sequence 1 1863
1 11 21 31 41 51
I I I I I I
ATGAGTAAGA GCAAATGCTC CGTGGGACTC ATGTCTTCCG TGGTGGCCCC GGCTAAGGAG 60
CCCAATGCCG TGGGCCCGAA GGAGGTGGAG CTCATCCTTG TCAAGGAGCA GAACGGAGTG 120
CAGCTCACCA GCTCCACCCT CACCAACCCT CGGCAGAGCC CCGTGGAGGC CCAGGATCGG 180
GAGACCTGGG GCAAGAAGAT CGACTTTCTC CTGTCCGTCA TTGGCTTTGC TGTGGACCTG 240
GCCAACGTCT GGCGGTTCCC CTACCTGTGC TACAAAAATG GTGGCGGTGC CTTCCTGGTC 300
CCCTACCTGC TCTTCATGGT CATTGCTGGG ATGCCACTTT TCTACATGGA GCTGGCCCTC 360
GGCCAGTTCA ACAGGGAAGG GGCCGCTGGT GTCTGGAAGA TCTGCCCCAT ACTGAAAGGT 420
GTGGGCTTCA CGGTCATCCT CATCTCACTG TATGTCGGCT TCTTCTACAA CGTCATCATC 480
GCCTGGGCGC TGCACTATCT CTTCTCCTCC TTCACCACGG AGCTCCCCTG GATCCACTGC 540
AACAACTCCT GGAACAGCCC CAACTGCTCG GATGCCCATC CTGGTGACTC CAGTGGAGAC 600
AGCTCGGGCC TCAACGACAC TTTTGGGACC ACACCTGCTG CCGAGTACTT TGAACGTGGC 660
GTGCTGCACC TCCACCAGAG CCATGGCATC GACGACCTGG GGCCTCCGCG GTGGCAGCTC 720
ACAGCCTGCC TGGTGCTGGT CATCGTGCTG CTCTACTTCA GCCTCTGGAA GGGCGTGAAG 780
ACCTCAGGGA AGGTGGTATG GATCACAGCC ACCATGCCAT ACGTGGTCCT CACTGCCCTG 840
CTCCTGCGTG GGGTCACCCT CCCTGGAGCC ATAGACGGCA TCAGAGCATA CCTGAGCGTT 900
GACTTCTACC GGCTCTGCGA GGCGTCTGTT TGGATTGACG CGGCCACCCA GGTGTGCTTC 960
TCCCTGGGCG TGGGGTTCGG GGTGCTGATC GCCTTCTCCA GCTACAACAA GTTCACCAAC 1020
AACTGCTACA GGGACGCGAT TGTCACCACC TCCATCAACT CCCTGACGAG CTTCTCCTCC 1080
GGCTTCGTCG TCTTCTCCTT CCTGGGGTAC ATGGCACAGA AGCACAGTGT GCCCATCGGG 1140
GACGTGGCCA AGGACGGGCC AGGGCTGATC TTCATCATCT ACCCGGAAGC CATCGCCACG 1200
CTCCCTCTGT CCTCAGCCTG GGCCGTGGTC TTCTTCATCA TGCTGCTCAC CCTGGGTATC 1260
GACAGCGCCA TGGGTGGTAT GGAGTCAGTG ATCACCGGGC TCATCGATGA GTTCCAGCTG 1320
CTGCACAGAC ACCGTGAGCT CTTCACGCTC TTCATCGTCC TGGCGACCTT CCTCCTGTCC 1380
CTGTTCTGCG TCACCAACGG TGGCATCTAC GTCTTCACGC TCCTGGACCA TTTTGCAGCC 1440
GGCACGTCCA TCCTCTTTGG AGTGCTCATC GAAGCCATCG GAGTGGCCTG GTTCTATGGT 1500
GTTGGGCAGT TCAGCGACGA CATCCAGCAG ATGACCGGGC AGCGGCCCAG CCTGTACTGG 1560
CGGCTGTGCT GGAAGCTGGT CAGCCCCTGC TTTCTCCTGT TCGTGGTCGT GGTCAGCATT 1620
GTGACCTTCA GACCCCCCCA CTACGGAGCC TACATCTTCC CCGACTGGGC CAACGCGCTG 1680
GGCTGGGTCA TCGCCACATC CTCCATGGCC ATGGTGCCCA TCTATGCGGC CTACAAGTTC 1740
TGCAGCCTGC CTGGGTCCTT TCGAGAGAAA CTGGCCTACG CCATTGCACC CGAGAAGGAC 1800
CGTGAGCTGG TGGACAGAGG GGAGGTGCGC CAGTTCACGC TCCGCCACTG GCTCAAGGTG 1860
TAG 1863
Seq ID NO 66 DNA Sequence
Nucleic Acid Accession # NM_022073 1
Coding sequence 327 1046
1 11 21 31 41 51
I I I I I I
GAGTCTC-GCC GCAGTCGCGG CAGTGGTGGC TTCCCATCCC CAAAAGGCGC CCTCCGACTC 60
CTTGCGCCGC ACTGCTCGCC GGGCCAGTCC GGAAACGGGT CGTGGAGCTC CGCACCACTC 120
CCGCTGGTTC CCGAAGGCAG ATCCCTTCTC CCGAGAGTTG CGAGAAACTT TCCCTTGTCC 180
CCGACGCTGC AGCGGCTCGG GTACCGTGGC AGCCGCAGGT TTCTGAACCC CGGGCCACGC 240
TCCCCGCGCC TCGGCTTCGC GCTCGTGTAG ATCGTTCCCT CTCTGGTTGC ACGCTGGGGA 300
TCCCGGACCT CGATTCTGCG GGCGAGATGC CCCTGGGACA CATCATGAGG CTGGACCTGG 360
AGAAAATTGC CCTGGAGTAC ATCGTGCCCT GTCTGCACGA GGTGGGCTTC TGCTACCTGG 420
ACAACTTCCT GGGCGAGGTG GTGGGCGACT GCGTCCTGGA GCGCGTCAAG CAGCTGCACT 480
GCACCGGGGC CCTGCGGGAC GGCCAGCTGG CGGGGCCGCG CGCCGGCGTC TCCAAGCGAC 540
ACCTGCGGGG CGACCAGATC ACGTGGATCG GGGGCAACGA GGAGGGCTGC GAGGCCATCA 600
GCTTCCTCCT GTCCCTCATC GACAGGCTGG TCCTCTACTG CGGGAGCCGG CTGGGCAAAT 660
ACTACGTCAA GGAGAGGTCT AAGGCAATGG TGGCTTGCTA TCCGGGAAAT GGAACAGGTT 720
ATGTTCGCCA CGTGGACAAC CCCAACGGTG ATGGTCGCTG CATCACCTGC ATCTACTATC 780
TGAACAAGAA TTGGGATGCC AAGCTACATG GTGGGATCCT GCGGATATTT CCAGAGGGGA 840
AATCATTCAT AGCAGATGTG GAGCCCATTT TTGACAGACT CCTGTTCTTC TGGTCAGATC 900
GTAGGAACCC ACACGAAGTG CAGCCCTCTT ACGCAACCAG ATATGCTATG ACTGTCTGGT 960
ACTTTGATGC TGAAGAAAGG GCAGAAGCCA AAAAGAAATT CAGGAATTTA ACTAGGAAAA 1020
CTGAATCTGC CCTCACTGAA GACTGACCGT GCTCTGAAAT CTGCTGGCCT TGTTCATTTT 1080
AGTAACGGTT CCTGAATTCT CTTAAATTCT TTGAGATCCA AAGATGGCCT CTTCAGTGAC 1140
AACAATCTCC CTGCTACTTC TTGCATCCTT CACATCCCTG TCTTGTGTGT GGTACTTCAT 1200
GTTTTCTTGC CAAGACTGTG TTGATCTTCA GATACTCTCT TTGCCAGATG AAGTTATTTG 1260
CTAACTCCAG AAATTCCTGC AGACATCCTA CTCGGCCAGC GGTTTACCTG A AGATTCGG 1320
TAATACTATC AAGAGAAGAG CCTAGGAGCA CAGCGAGGGA ATGAACCTTA CTTGCACTTT 1380
ATGTATACTT CCTGATTTGA AAGGAGGAGG TTTGAAAAGA AAAAAATGGA GGTGGTAGAT 1440
GCCACAGAGA GGCATCACGG AAGCCTTAAC AGCAGGAAAC AGAGAAATTT GTGTCATCTG 1500
AACAATTTCC AGATGTTCTT AATCCAGGGC TGTTGGGGTT TCTGGAGAAT TATCACAACC 1560
TAATGACATT AATACCTCTA GAAAGGGCTG CTGTCATAGT GAACAATTTA TAAGTGTCCC 1620
ATGGGGCAGA CACTCCTTTT TTCCCAGTCC TGCAACCTGG ATTTTCTGCC TCAGCTCCAT 1680
TTTGCTGAAA ATAATGACTT TCTGAATAAA GATGGCAACA CAATTTTTTC TCCATTTTCA 1740
GTTCTTACCT GGGAACCTAA TTCCCCAGAA GCTAAAAAAC TAGACATTAG TTGTTTTGGT 1800
TGCTTTGTTG GAATGGAATT TAAATTTAAA TGAAAGGAAA AATATATCCC TGGTAGTTTT 1860
GTGTTAACCA CTGATAACTG TGGAAAGAGC TAGGTCTACT GATATACAAT AAACATGTGT 1920
GCATCTTGAA CAATTTGAGA GGGGAGGTGG AGTTGGAAAT GTGGGTGTTC CTGTTTTTTT 1980
-rτττττττ-r-r TTT-rTTTTTT AGTTTTCCTT TTTAATGAGC TCACCCTTTA ACACAAAAAA 2040
AGCAGGGTGA TGTATTTTAA AAAAGGAAGT GGAAATAAAA AAATCTCAAA GCTATTTGAG 2100
TTCTCGTCTG TCCCTAGCAG TCTTTCTTCA GCTCACTTGG CTCTCTAGAT CCACTGTGGT 2160
TGGCAGTATG ACCAGAATCA TGGAACTTGC TAGAACTGTG GAAGCTTCTA CTCCTGCAGT 2220
AAGCACAGAT CGCACTGCCT CAATAACTTG GTATTGAGCA CGTATTTTGC AAAAGCTACT 2280
TTTCCTAGTT TTCAGTATTA CTTTCATGTT TTAAAAATCC CTTTAATTTC TTGCTTGAAA 2340
ATCCCATGAA CATTAAAGAG CCAGAAATAT TTTCCTTTGT TATGTACGGA TATATATATA 2400 TATATAGTCT TCCAAGATAG AAGTTTACTT TTTCCTCTTC TGGTTTTGGA AAATTTCCAG 2460
ATAAGACATG TCACCATTAA TTCTCAACGA CTGCTCTATT TTGTTGTACG GTAATAGTTA 2520
TCACCTTCTA AATTACTATG TAATTTACTC ACTTATTATG TTTATTGTCT TGTATCCTTT 2580
CTCTGGAGTG TAAGCACAAT GAAGACAGGA ATTTTGTATA TTTTTAACCA ATGCAACATA 2640 CTCTCAGCAC CTAAAATAGT GCCGGGAACA TAGTAAGGGC TCAGTAAATA CTTGTTGAAT 2700
AAACTCAGTC TCCTACATTA GCATTCTAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 2760
AAAAAAAAAG 2770
Seq ID NO: 67 DNA Sequence Nucleic Acid Accession tt: NM_139314.1 Coding sequence: 196..1416 1 11 21 31 41 51
I I I I I I
ATAAAAACCG TCCTCGGGCG CGGCGGGGAG AAGCCGAGCT GAGCGGATCC TCACACGACT 60 GTGATCCGAT TCTTTCCAGC GGCTTCTGCA ACCAAGCGGG TCTTACCCCC GGTCCTCCGC 120
GTCTCCAGTC CTCGCACCTG GAACCCCAAC GTCCCCGAGA GTCCCCGAAT CCCCGCTCCC 180
AGGCTACCTA AGAGGATGAG CGGTGCTCCG ACGGCCGGGG CAGCCCTGAT GCTCTGCGCC 240
GCCACCGCCG TGCTACTGAG CGCTCAGGGC GGACCCGTGC AGTCCAAGTC GCCGCGCTTT 300
GCGTCCTGGG ACGAGATGAA TGTCCTGGCG CACGGACTCC TGCAGCTCGG CCAGGGGCTG 360 CGCGAACACG CGGAGCGCAC CCGCAGTCAG CTGAGCGCGC TGGAGCGGCG CCTGAGCGCG 420
TGCGGGTCCG CCTGTCAGGG AACCGAGGGG TCCACCGACC TCCCGTTAGC CCCTGAGAGC 480
CGGGTGGACC CTGAGGTCCT TCACAGCCTG CAGACACAAC TCAAGGCTCA GAACAGCAGG 540
ATCCAGCAAC TCTTCCACAA GGTGGCCCAG CAGCAGCGGC ACCTGGAGAA GCAGCACCTG 600
CGAATTCAGC ATCTGCAAAG CCAGTTTGGC CTCCTGGACC ACAAGCACCT AGACCATGAG 660 GTGGCCAAGC CTGCCCGAAG AAAGAGGCTG CCCGAGATGG CCCAGCCAGT TGACCCGGCT 720
CACAATGTCA GCCGCCTGCA CCGGCTGCCC AGGGATTGCC AGGAGCTGTT CCAGGTTGGG 780
GAGAGGCAGA GTGGACTATT TGAAATCCAG CCTCAGGGGT CTCCGCCATT TTTGGTGAAC 840
TGCAAGATGA CCTCAGATGG AGGCTGGACA GTAATTCAGA GGCGCCACGA TGGCTCAGTG 900
GACTTCAACC GGCCCTGGGA AGCCTACAAG GCGGGGTTTG GGGATCCCCA CGGCGAGTTC 960 TGGCTGGGTC TGGAGAAGGT GCATAGCATC ACGGGGGACC GCAACAGCCG CCTGGCCGTG 1020
CAGCTGCGGG ACTGGGATGG CAACGCCGAG TTGCTGCAGT TCTCCGTGCA CCTGGGTGGC 1080
GAGGACACGG CCTATAGCCT GCAGCTCACT GCACCCGTGG CCGGCCAGCT GGGCGCCACC 1140
ACCGTCCCAC CCAGCGGCCT CTCCGTACCC TTCTCCACTT GGGACCAGGA TCACGACCTC 1200
CGCAGGGACA AGAACTGCGC CAAGAGCCTC TCTGGAGGCT GGTGGTTTGG CACCTGCAGC 1260 CATTCCAACC TCAACGGCCA GTACTTCCGC TCCATCCCAC AGCAGCGGCA GAAGCTTAAG 1320
AAGGGAATCT TCTGGAAGAC CTGGCGGGGC CGCTACTACC CGCTGCAGGC CACCACCATG 1380
TTGATCCAGC CCATGGCAGC AGAGGCAGCC TCCTAGCGTC CTGGCTGGGC CTGGTCCCAG 1440
GCCCACGAAA GACGGTGACT CTTGGCTCTG CCCGAGGATG TGGCCGTTCC CTGCCTGGGC 1500
AGGGGCTCCA AGGAGGGGCC ATCTGGAAAC TTGTGGACAG AGAAGAAGAC CACGACTGGA 1560 GAAGCCCCCT TTCTGAGTGC AGGGGGGCTG CATGCGTTGC CTCCTGAGAT CGAGGCTGCA 1620
GGATATGCTC AGACTCTAGA GGCGTGGACC AAGGGGCATG GAGCTTCACT CCTTGCTGGC 1680
CAGGGAGTTG GGGACTCAGA GGGACCACTT GGGGCCAGCC AGACTGGCCT CAATGGCGGA 1740
CTCAGTCACA TTGACTGACG GGGACCAGGG CTTGTGTGGG TCGAGAGCGC CCTCATGGTG 1800
CTGGTGCTGT TGTGTGTAGG TCCCCTGGGG ACACAAGCAG GCGCCAATGG TATCTGGGCG 1860 GAGCTCACAG AGTTCTTGGA ATAAAAGCAA CCTCAGAACA CTTAAAAAAA AAAAAAAAAA 1920
AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAA 1967
Seq ID NO: 68 DNA Sequence Nucleic Acid Accession tt : NM_016109.2 Coding sequence: 196..1416
1 11 21 31 41 51
I I I I I I
ATAAAAACCG TCCTCGGGCG CGGCGGGGAG AAGCCGAGCT GAGCGGATCC TCACACGACT 60
GTGATCCGAT TCTTTCCAGC GGCTTCTGCA ACCAAGCGGG TCTTACCCCC GGTCCTCCGC 120
GTCTCCAGTC CTCGCACCTG GAACCCCAAC GTCCCCGAGA GTCCCCGAAT CCCCGCTCCC 180
AGGCTACCTA AGAGGATGAG CGGTGCTCCG ACGGCCGGGG CAGCCCTGAT GCTCTGCGCC 240
GCCACCGCCG TGCTACTGAG CGCTCAGGGC GGACCCGTGC AGTCCAAGTC GCCGCGCTTT 300
GCGTCCTGGG ACGAGATGAA TGTCCTGGCG CACGGACTCC TGCAGCTCGG CCAGGGGCTG 360
CGCGAACACG CGGAGCGCAC CCGCAGTCAG CTGAGCGCGC TGGAGCGGCG CCTGAGCGCG 420
TGCGGGTCCG CCTGTCAGGG AACCGAGGGG TCCACCGACC TCCCGTTAGC CCCTGAGAGC 480
CGGGTGGACC CTGAGGTCCT TCACAGCCTG CAGACACAAC TCAAGGCTCA GAACAGCAGG 540
ATCCAGCAAC TCTTCCACAA GGTGGCCCAG CAGCAGCGGC ACCTGGAGAA GCAGCACCTG 600
CGAATTCAGC ATCTGCAAAG CCAGTTTGGC CTCCTGGACC ACAAGCACCT AGACCATGAG 660
GTGGCCAAGC CTGCCCGAAG AAAGAGGCTG CCCGAGATGG CCCAGCCAGT TGACCCGGCT 720
CACAATGTCA GCCGCCTGCA CCGGCTGCCC AGGGATTGCC AGGAGCTGTT CCAGGTTGGG 780
GAGAGGCAGA GTGGACTATT TGAAATCCAG CCTCAGGGGT CTCCGCCATT TTTGGTGAAC 840
TGCAAGATGA CCTCAGATGG AGGCTGGACA GTAATTCAGA GGCGCCACGA TGGCTCAGTG 900
GACTTCAACC GGCCCTGGGA AGCCTACAAG GCGGGGTTTG GGGATCCCCA CGGCGAGTTC 960
TGGCTGGGTC TGGAGAAGGT GCATAGCATC ACGGGGGACC GCAACAGCCG CCTGGCCGTG 1020
CAGCTGCGGG ACTGGGATGG CAACGCCGAG TTGCTGCAGT TCTCCGTGCA CCTGGGTGGC 1080
GAGGACACGG CCTATAGCCT GCAGCTCACT GCACCCGTGG CCGGCCAGCT GGGCGCCACC 1140
ACCGTCCCAC CCAGCGGCCT CTCCGTACCC TTCTCCACTT GGGACCAGGA TCACGACCTC 1200
CGCAGGGACA AGAACTGCGC CAAGAGCCTC TCTGGAGGCT GGTGGTTTGG CACCTGCAGC 1260
CATTCCAACC TCAACGGCCA GTACTTCCGC TCCATCCCAC AGCAGCGGCA GAAGCTTAAG 1320
AAGGGAATCT TCTGGAAGAC CTGGCGGGGC CGCTACTACC CGCTGCAGGC CACCACCATG 1380
TTGATCCAGC CCATGGCAGC AGAGGCAGCC TCCTAGCGTC CTGGCTGGGC CTGGTCCCAG 1440
GCCCACGAAA GACGGTGACT CTTGGCTCTG CCCGAGGATG TGGCCAAGAC CACGACTGGA 1500
GAAGCCCCCT TTCTGAGTGC AGGGGGGCTG CATGCGTTGC CTCCTGAGAT CGAGGCTGCA 1560
GGATATGCTC AGACTCTAGA GGCGTGGACC AAGGGGCATG GAGCTTCACT CCTTGCTGGC 1620
CAGGGAGTTG GGGACTCAGA GGGACCACTT GGGGCCAGCC AGACTGGCCT CAATGGCGGA 1680
CTCAGTCACA TTGACTGACG GGGACCAGGG CTTGTGTGGG TCGAGAGCGC CCTCATGGTG 1740 CTGGTGCTGT TGTGTGTAGG TCCCCTGGGG ACACAAGCAG GCGCCAATGG TATCTGGGCG 1800 GAGCTCACAG AGTTCTTGGA ATAAAAGCAA CCTCAGAACA CTT 1843 Seq ID NO 69 DNA Sequence
Nucleic Acid Accession tt NM_001216 1
Coding sequence 43 1422
1 11 21 31 41 51
I I I I I I
GCCCGTACAC ACCGTGTGCT GGGACACCCC ACAGTCAGCC GCATGGCTCC CCTGTGCCCC 60
AGCCCCTGGC TCCCTCTGTT GATCCCGGCC CCTGCTCCAG GCCTCACTGT GCAACTGCTG 120
CTGTCACTGC TGCTTCTGAT GCCTGTCCAT CCCCAGAGGT TGCCCCGGAT GCAGGAGGAT 180
TCCCCCTTGG GAGGAGGCTC TTCTGGGGAA GATGACCCAC TGGGCGAGGA GGATCTGCCC 240
AGTGAAGAGG ATTCACCCAG AGAGGAGGAT CCACCCGGAG AGGAGGATCT ACCTGGAGAG 300
GAGGATCTAC CTGGAGAGGA GGATCTACCT GAAGTTAAGC CTAAATCAGA AGAAGAGGGC 360
TCCCTGAAGT TAGAGGATCT ACCTACTGTT GAGGCTCCTG GAGATCCTCA AGAACCCCAG 420
AATAATGCCC ACAGGGACAA AGAAGGGGAT GACCAGAGTC ATTGGCGCTA TGGAGGCGAC 480
CCGCCCTGGC CCCGGGTGTC CCCAGCCTGC GCGGGCCGCT TCCAGTCCCC GGTGGATATC 540
CGCCCCCAGC TCGCCGCCTT CTGCCCGGCC CTGCGCCCCC TGGAACTCCT GGGCTTCCAG 600
CTCCCGCCGC TCCCAGAACT GCGCCTGCGC AACAATGGCC ACAGTGTGCA ACTGACCCTG 660
CCTCCTGGGC TAGAGATGGC TCTGGGTCCC GGGCGGGAGT ACCGGGCTCT GCAGCTGCAT 720
CTGCACTGGG GGGCTGCAGG TCGTCCGGGC TCGGAGCACA CTGTGGAAGG CCACCGTTTC 780
CCTGCCGAGA TCCACGTGGT TCACCTCAGC ACCGCCTTTG CCAGAGTTGA CGAGGCCTTG 840
GGGCGCCCGG GAGGCCTGGC CGTGTTGGCC GCCTTTCTGG AGGAGGGCCC GGAAGAAAAC 900
AGTGCCTATG AGCAGTTGCT GTCTCGCTTG GAAGAAATCG CTGAGGAAGG CTCAGAGACT 960
CAGGTCCCAG GACTGGACAT ATCTGCACTC CTGCCCTCTG ACTTCAGCCG CTACTTCCAA 1020
TATGAGGGGT CTCTGACTAC ACCGCCCTGT GCCCAGGGTG TCATCTGGAC TGTGTTTAAC 1080
CAGACAGTGA TGCTGAGTGC TAAGCAGCTC CACACCCTCT CTGACACCCT GTGGGGACCT 1140
GGTGACTCTC GGCTACAGCT GAACTTCCGA GCGACGCAGC CTTTGAATGG GCGAGTGATT 1200
GAGGCCTCCT TCCCTGCTGG AGTGGACAGC AGTCCTCGGG CTGCTGAGCC AGTCCAGCTG 1260
AATTCCTGCC TGGCTGCTGG TGACATCCTA GCCCTGGTTT TTGGCCTCCT TTTTGCTGTC 1320
ACCAGCGTCG CGTTCCTTGT GCAGATGAGA AGGCAGCACA GAAGGGGAAC CAAAGGGGGT 1380
GTGAGCTACC GCCCAGCAGA GGTAGCCGAG ACTGGAGCCT AGAGGCTGGA TCTTGGAGAA 1440
TGTGAGAAGC CAGCCAGAGG CATCTGAGGG GGAGCCGGTA ACTGTCCTGT CCTGCTCATT 1500
ATGCCACTTC CTTTTAACTG CCAAGAAATT TTTTAAAATA AATATTTATA AT 1552
Seq ID NO 70 DNA Sequence
Nucleic Acid Accession tt NM_003039 1
Coding sequence 107 1612
1 11 21 31 41 51
I I I I I I
CTTCTCTCTC CATTCAGTGC ACGCGTTACT TTGGCTAAAA GGAGGTGAGC GGCACTCTGC 60
CCTTCCAGAG CAAGCATGGA GCAACAGGAT CAGAGCATGA AGGAAGGGAG GCTGACGCTT 120
GTGCTTGCCC TGGCAACCCT GATAGCTGCC TTTGGGTCAT CCTTCCAGTA TGGGTACAAC 180
GTGGCTGCTG TCAACTCCCC AGCACTGCTC ATGCAACAAT TTTACAATGA GACTTACTAT 240
GGTAGGACCG GTGAATTCAT GGAAGACTTC CCCTTGACGT TGCTGTGGTC TGTAACCGTG 300
TCCATGTTTC CATTTGGAGG GTTTATCGGA TCCCTCCTGG TCGGCCCCTT GGTGAATAAA 360
TTTGGCAGAA AAGGGGCCTT GCTGTTCAAC AACATATTTT CTATCGTGCC TGCGATCTTA 420
ATGGGATGCA GCAGAGTCGC CACATCATTT GAGCTTATCA TTATTTCCAG ACTTTTGGTG 480
GGAATATGTG CAGGTGTATC TTCCAACGTG GTCCCCATGT ACTTAGGGGA GCTGGCCCCT 540
AAAAACCTGC GGGGGGCTCT CGGGGTGGTG CCCCAGCTCT TCATCACTGT TGGCATCCTT 600
GTGGCCCAGA TCTTTGGTCT TCGGAATCTC CTTGCAAACG TAGATGGCTG GCCGATCCTG 660
CTGGGGCTGA CCGGGGTCCC CGCGGCGCTG CAGCTCCTTC TGCTGCCCTT CTTCCCCGAG 720
AGCCCCAGGT ACCTGCTGAT TCAGAAGAAA GACGAAGCGG CCGCCAAGAA AGCCCTACAG 780
ACGCTGCGCG GCTGGGACTC TGTGGACAGG GAGGTGGCCG AGATCCGGCA GGAGGATGAG 840
GCAGAGAAGG CCGCGGGCTT CATCTCCGTG CTGAAGCTGT TCCGGATGCG CTCGCTGCGC 900
TGGCAGCTGC TGTCCATCAT CGTCCTCATG GGCGGCCAGC AGCTGTCGGG CGTCAACGCT 960
ATCTACTACT ACGCGGACCA GATCTACCTG AGCGCCGGCG TGCCGGAGGA GCACGTGCAG 1020
TACGTGACGG CCGGCACCGG GGCCGTGAAC GTGGTCATGA CCTTCTGCGC CGTGTTCGTG 1080
GTGGAGCTCC TGGGTCGGAG GCTGCTGCTG CTGCTGGGCT TCTCCATCTG CCTCATAGCC 1140
TGCTGCGTGC TCACTGCAGC TCTGGCACTG CAGGACACAG TGTCCTGGAT GCCATACATC 1200
AGCATCGTCT GTGTCATCTC CTACGTCATA GGACATGCCC TCGGGCCCAG TCCCATACCC 1260
GCGCTGCTCA TCACTGAGAT CTTCCTGCAG TCCTCTCGGC CATCTGCCTT CATGGTGGGG 1320
GGCAGTGTGC ACTGGCTCTC CAACTTCACC GTGGGCTTGA TCTTCCCGTT CATCCAGGAG 1380
GGCCTCGGCC CGTACAGCTT CATTGTCTTC GCCGTGATCT GCCTCCTCAC CACCATCTAC 1440
ATCTTCTTGA TTGTCCCGGA GACCAAGGCC AAGACGTTCA TAGAGATCAA CCAGATTTTC 1500
ACCAAGATGA ATAAGGTGTC TGAAGTGTAC CCGGAAAAGG AGGAACTGAA AGAGCTTCCA 1560
CCTGTCACTT CGGAACAGTG ACTCTGGAGA GGAAGCCAGT GGAGCTGGTC TGCCAGGGGC 1620
TTCCCACTTT GGCTTATTTT TCTGACTTCT AGCTGTCTGT GAATATCCAG AAATAAAACA 1680
ACTCTGATGT GGAATGCAGT CCTCATCTCC AGCCTCCCCA CCCCAGTGGG AACTGTGCAA 1740
AGGGCTGCCT TGCTGTTCTT GAAGCTGGGC TGTCTCTCTC CATGTTGGCC TGTCACCAGA 1800
CCCGAGTCAA TTAAACAGCT GGTCCTCCAC TTTGCTGGTT CAGCCTTCGT GTGGCTCCTG 1860
GTAACGTGGC TCCACCTTGA TGGGTCAACC TTTGTGTGGC TCCTGGTAAC ATAACAACAA 1920
CAGTTACTAT AGTGGTGAGA TGGAAGGAAT CAAATTTTGC CAGAGAAACT AACTCGGTGG 1980
CCCCAACAGG TCTTCCGGGG CCATGGGCAT TTGTTTAGAG CCAAATTCAT CCTCTTACCA 2040
GATCCTTTTC CAGAAATACC TGTCTAGGAA GGTGTGATGT CAGAAACAAT GACATCCAGA 2100
AAGCTGAGGA ACAGGTTCCT GTGGAGACAC TGAGTCAGAA TTCTTCATCC AAATTATTTT 2160
GTTAGTGGAA AATGGAATTG CTTCTGTGTA GTCAATAAAA TGAACCTGAT CACTTTTC 2218
Seq ID NO 71 DNA Sequence
Nucleic Acid Accession tt NM_001252 1
Coding sequence 138 719
1 11 21 31 41 51 i i i i i i
GGCTGGTCCC CTGACAGGTT GAAGCAAGTA GACGCCCAGG AGCCCCGGGA GGGGGCTGCA 60
GTTTCCTTCC TTCCTTCTCG GCAGCGCTCC GCGCCCCCAT CGCCCCTCCT GCGCTAGCGG 120
AGGTGATCGC CGCGGCGATG CCGGAGGAGG GTTCGGGCTG CTCGGTGCGG CGCAGGCCCT 180
ATGGGTGCGT CCTGCGGGCT GCTTTGGTCC CATTGGTCGC GGGCTTGGTG ATCTGCCTCG 240 TGGTGTGCAT CCAGCGCTTC GCACAGGCTC AGCAGCAGCT GCCGCTCGAG TCACTTGGGT 300
GGGACGTAGC TGAGCTGCAG CTGAATCACA CAGGACCTCA GCAGGACCCC AGGCTATACT 360
GGCAGGGGGG CCCAGCACTG GGCCGCTCCT TCCTGCATGG ACCAGAGCTG GACAAGGGGC 420
AGCTACGTAT CCATCGTGAT GGCATCTACA TGGTACACAT CCAGGTGACG CTGGCCATCT 480 GCTCCTCCAC GACGGCCTCC AGGCACCACC CCACCACCCT GGCCGTGGGA ATCTGCTCTC S40
CCGCCTCCCG TAGCATCAGC CTGCTGCGTC TCAGCTTCCA CCAAGGTTGT ACCATTGCCT 600
CCCAGCGCCT GACGCCCCTG GCCCGAGGGG ACACACTCTG CACCAACCTC ACTGGGACAC 660
TTTTGCCTTC CCGAAACACT GATGAGACCT TCTTTGGAGT GCAGTGGGTG CGCCCCTGAC 720
CACTGCTGCT GATTAGGGTT TTTTAAATTT TATTTTATTT TATTTAAGTT CAAGAGAAAA 780 AGTGTACACA CAGGGGCCAC CCGGGGTTGG GGTGGGAGTG TGGTGGGGGG TAGTGGTGGC 840
AGGACAAGAG AAGGCATTGA GCTTTTTCTT TCATTTTCCT ATTAAAAA 888
Seq ID NO 72 DNA Sequence
Nucleic Acid Accession tt NM_018092 2
Coding sequence 13 618
1 11 21 31 41 51
I I I I I I
AGCAGGTTTC GAATGCTCTT TACTTCCTTT GTGGAGCAAA AGAAAAAAGC AGGAGTATTT 60
GAACAAATCA CTAAGACTCA TGGAACAATT ATTGGCATTA CTTCAGGGAT TGTCTTGGTC 120
CTTCTCATTA TTTCTATTTT AGTACAAGTG AAACAGCCTC GAAAAAAGGT CATGGCTTGC 180
AAAACCGCTT TTAATAAAAC CGGGTTCCAA GAAGTGTTTG ATCCTCCTCA TTATGAACTG 240
TTTTCACTAA GGGACAAAGA GATTTCTGCA GACCTGGCAG ACTTGTCGGA AGAATTGGAC 300
AACTACCAGA GGATGCGGCG CTCCTCCACC GCCTCCCGCT GCATCCACGA CCACCACTGT 360
GGGTCGCAGG CCTCCAGCGT CAAACAAAGC AGGACCAACC TCAGTTCCAT GGAGCTTCCT 420
CTCCGAAATG ACTTTGCACA ACCACAGCCA ATGAAAACAT TTAA AGCAC CTTCAAGAAA 480
AGTAGTTACA CTTTCAAACA GGGACATGAG TGCCCTGAGC AGGCCCTGGA AGACCGAGTA 540
ATGGAGGAGA TTCCCTGTGA AATTTATGTC AGGGGGCGAG AAGATTCTGC ACAAGCATCC 600
ATATCCATTG ACTTCTAATC TTCTGCTAAT GGTGATGTGA ATTCTTAGGG TGTGTACGTA 660
CGCAGCCTCC AGGGCACCAT ACTGTTTCCA GCAGCCAACC CTTTTCTCCC ATCACAACTA 720
CGAAGACCTT GATTTACCGT TAACCTATTG TATGGTGATG TTTTTATTCT CTCAGGCAGT 780
CTATATATGT TAAACCAATC AAGGAACTTA CTCTATTCAG TGGAAACAAT AATCATCTCT 840
ATTGCTTGGT GTCATTTATA GGAAGCACTG CCAGTTAAAG AGCATTAGAA GAGGTGGTTG 900
GATGGAGCCA GGCTCAGGCT GCCTCTTCGT TTTAGCAACA AGAAGACTGC TCTTGACTGA 960
TAACAGCTCT GTCAATATTT TGATGCCACA ATAAACTTGA TTTTTCTTTA CATTCCTTTT 1020
ATTTTTCCTT TCTCTAAATT TAATTTGTTT TATAAGCCTA TCGTTTTACC ATTTCATTTT 1080
CTTACATAAG TACAAGTGGT TAATGTACCA CATACTTCAG TATAGGCATT TGTTCTTGAG 1140
TGTGTCAAAA TACAGCTAGT TACTGTGCCA ATTAAGACCC AGTTGTATTT CACCCATCTG 1200
TTTCTTCTTG GCTAATCTCT GTACTTCTGC CTTTTAATTA CTGGGCCCTT ATTCCTTATT 1260
TTCTGTGAGA AATAATAGAT GATATGATTT ATTACCTTTC AATTATATTT TTCTCAGTTA 1320
TACTAGAAAA TTTCATAATC CTGGGATATA TGTACCATTG TCAGCTATGA CTAAAAATTT 1380
GAAAAAGATA AAAATTTCTA GCAAGCCTTT GAAGTTTACC AAGTATAGTC ACATTCAGTG 1440
ACAGCCCATT CATTCCAGTA AAGAATCATT TCATTCACTT TGGGAGAGGC CTATAATTAC 1500
ATTTATTTGC AATGTTTCTC TTCGCTAGAT TGTTACATAG CTCCCATTCT GTTGGTTTTG 1560
CTTACAGCAT ATGGTAACCA AGGTTAGATG CCAGTTAAAA TTCCTTAGAA ATTGGATGAG 1620
CCTTGAGATT GCTTCTTAAC TGGGACATGA CATTTTTCTA GCTCTTATCA AGAATAACAA 1680
CTTCCACTTT TTTTTAAACT GCACTTTTGA CTTTTTTTAT GGTATAAAAA CAATAATTTA 1740
TAAACATAAA AGCTCATTGT GTTTTTTAGA CTTTTGATAT TATTTGA AC TGTACAAACT 1800
TTATTAAATC AAGATGAAAG ACCTACAGGA CAGATTCCTT TCAGTGTTCA CATCAGTGGC 1860
TTTGTATGCA AATATGCTGT GTTGGACCTG GACGCTATAA CTTATTGTAA AGACCTTGGA 1920
AATGTGGACA TAAGCTCTTT CTTTCCTTTT GTTACTGTAT TTAGTTTGTG ATAAATTTTT 1980
CACTGTGTGA TATTTATGCT CTAAATCACT ACACAAATCC CATATTAAAA TATACATTGT 2040
ACCTGACCCT TTAATCATGT TATTTATGCC ACCAAGGTTG TGGATCTTAA GGTATGTATG 2100
GAAAGGAACT CATTTATCAA ATTGTAAGTA ATACAGACAT GCCATTTAAA AGAGGTAAAT 2160
TCTTGTTTTC TATATTTTGT TAGTAAATTC TCAATGAAAT AAGTTGAAGT TTCACTGGAT 2220
TTCATTAACT TTTAAATATT ACATATATGT GTTTTCTCAG ATTAGTGAAA ATTGTGACCT 2280
TAAATTTAAT ACACATATAC TGCCTCAG 2308
Seq ID NO 73 DNA Sequence
Nucleic Acid Accession tt Eos sequence
1 11 21 31 41 51
I I I I I I
GCTGAATGTT TTTTTCATTT TCCTGAGAGA TGCAAATGTT CATTCATTCA TCTCATTATA 60
CAACACAGTA CATAAATGTA GCTTCAGAGC GTATTAAGTG CTTTTATACA CAAGTGCTGG 120
CTGTGTGGAC CAGGTGGTAG CTCATTTAGG CCCCAAATTC ATTAAGGGCA GGGTCTGACT 180
CTTAGGCTTC TTAATATTTG GTTTGGTGCA TGGTCAAGAG CTGGACCCAC ATGTTGCATA 240
GCAGCAGGGC TGATATGTTT AAAGACGCTG GGCTTTTTCT GCTCTGGGGC CCTTTCCCGG 300
GGGTTCCGGT GAGTCCCTCC CCAGGTGGGT CTGCCCCCAC CCGTGTGGGC GGGATTAGCT 360
CCCAGAGGCT GGCCAGGCCC CACCTGGGGG AGGCTTGAGG GCAGGGCCCC AAGGCTGAGA 420
TTCAGGCTTG GGGGAACAGA GCAGGAAAGA GACCCGGTAC CGAAAGTGAG CGGGGCAGGC 480
ACCTAGTCAC ATGGGTAATG GGCAGGGGTC GGTCACTGGC TTTGGCTCCA GGGCCAGAGC 540
AGTCTGACTT AGTGTTGAGC TCCAAGCATG GAACACTGGA GTTGGTTCAT TTTGACCAGC 600
AAGCCTCTAA ATGGGTGCCT TGATTACCCA CCGCAAGGAG AGGGCAGTTG CCTTTTTATG 660
ACATGTTAAT TCCAGCCAGG TGAGTCACCA GGTAGCTCTC ATCCTCCTGC CAGGCTCCCC 720
TGCCTGTCGG TTTGGCATTG TCAGATAATG TGATCATTCA TTGAAGTGAC ATTTGAGTTC 780
CAAACCAGTT TTCTCCTTTA ACCATTTCAC CCTCAGGAGT GATTCTCCTT TGTTTGGCAT 840
TGTCAGGGAA TGTGATGATC CATTCAAATG ACTTTTGAGT TCCAAATAGT GTTTCTACTT 900
TAACTTCCTA AATGAAAAAA AAAAAAAAAA AAA 9 3
Seq ID NO 74 DNA Sequence Nucleic Ac id Accession # Eos sequence
1 11 21 31 41 51
I I I I I I
TTTTTTTTTT TCATTTAGGA AGTTAAAGTA GAAACACTAT TTGGAACTCA AAAGTCATTT 60 GAATGGATCA TCACATTCCC TGACAATGCC AAACAAAGGA GAATCACTCC TGAGGGTGAA 120 ATGGTTAAAG GAGAAAACTG GTTTGGAACT CAAATGTCAC TTCAATGAAT GATCACATTA 180
TCTGACAATG CCAAACCGAC AGGCAGGGGA GCCTGGCAGG AGGATGAGAG CTACCTGGTG 240
ACTCACCTGG CTGGAATTAA CATGTCATAA AAAGGCAACT GCCCTCTCCT TGCGGTGGGT 300
AATCAAGGCA CCCATTTAGA GGCTTGCTGG TCAAAATGAA CCAACTCCAG TGTTCCATGC 360
TTGGAGCTCA ACACTAAGTC AGACTGCTCT GGCCCTGGAG CCAAAGCCAG TGACCGACCC 420
CTGCCCATTA CCCATGTGAC TAGGTGCCTG CCCCGCTCAC TTTCGGTACC GGGTCTCTTT 480
CCTGCTCTGT TCCCCCAAGC CTGAATCTCA GCCTTGGGGC CCTGCCCTCA AGCCTCCCCC S40
AGGTGGGGCC TGGCCAGCCT C 561
Seq ID NO 75 DNA Sequence
Nucleic Acid Accession tt Eos sequence
Coding sequence 1 459
1 11 21 31 41 51
I I I I I I
ATCATTGCAG CCACGATTAA TAATGCCAGC ATGACTTCCC CAATTGACAA TGCTGGACTT 60
GCAGCAGATG ACTTCAAAAT GAATGCATCC TTGCAGACAC AGATCTCCAC GGATGCTGAA 120
GCAGTTAGCT CGGCCAAGAG TGAGATAATG GAGCTGAAAC AAGTCCTCCA GTCCCTCCAG 180
CATGAACTGC AGTCTGTCTT GGCCATGCAA AGCTCCCCAG AAGGAACCCT GGCTGACACA 240
GAAGCTGGCT ACGTGGCTCA GCTGTCAGAA ATTAAGATGT ATATCAGCAT CCTGGAGGAG 300
CAGATCTGCC AGATCCGGGG CGAGACTGAA TACCAGAACA CAGAGTATGC ACAACTGCAG 360
GACATCAAGA CACGCCTGGA GGTGGAGATC GAGACCTACC ACCGCCTGCT CGGTGGAGAG 420
GGAGGTTCTG AGGCCAGAGA AGCTGAATCT AAAGGATGAT TCTCTGTGGA CTCCAAAGGA 480
ATAACCAACA CAGCTCAATC GAGGGGAAGA GTCGCTTTTT AAAATTCACA TAAAAGCAGA 540
GGAACCAGGC TGGTGACGGA TAATGACCAA CTAATTTCAT CTCAACACTG TTTCTGATGT 600
AAAATTCAAG AGTAAGATGC AGGCAGCTGA GTCCTGTCCC CAGGATGTAA ATGATGACAC 660
CTAACAAAGG CGTGCTGAAG CACTGCAACA AACCTGCGGC CACAGAGCTG CAGCTACTCC 720
TGTAATCCTT TCTCAGATTC TTTTGTCTTA TTGGTTCGGT TTTGTCTTTA AATTGCAAAA 780
TGTGTTTTCC TTCTTAATCA TTCTGTGTCG ATAAACTTTT TGCCTGTTGC AAATCAA 837
Seq ID NO 76 DNA Sequence
Nucleic Acid Accession # NM 00326S 2
Coding sequence 102 2816
1 11 21 31 41 51
I I I I I I
CACTTTCGAG AGTGCCGTCT ATTTGCCACA CACTTCCCTG ATGAAATGTC TGGATTTGGA 60
CTAAAGAAAA AAGGAAAGGC TAGCAGTCAT CCAACAGAAT CATGAGACAG ACTTTGCCTT 120
GTATCTACTT TTGGGGGGGC CTTTTGCCCT TTGGGATGCT GTGTGCATCC TCCACCACCA 180
AGTGCACTGT TAGCCATGAA GTTGCTGACT GCAGCCACCT GAAGTTGACT CAGGTACCCG 2 0
ATGATCTACC CACAAACATA ACAGTGTTGA ACCTTACCCA TAATCAACTC AGAAGATTAC 300
CAGCCGCCAA CTTCACAAGG TATAGCCAGC TAACTAGCTT GGATGTAGGA TTTAACACCA 360
TCTCAAAACT GGAGCCAGAA TTGTGCCAGA AACTTCCCAT GTTAAAAGTT TTGAACCTCC 420
AGCACAATGA GCTATCTCAA CTTTCTGATA AAACCTTTGC CTTCTGCACG AATTTGACTG 480
AACTCCATCT CATGTCCAAC TCAATCCAGA AAATTAAAAA TAATCCCTTT GTCAAGCAGA 540
AGAATTTAAT CACATTAGAT CTGTCTCATA ATGGCTTGTC ATCTACAAAA TTAGGAACTC 600
AGGTTCAGCT GGAAAATCTC CAAGAGCTTC TATTATCAAA CAATAAAATT CAAGCGCTAA 660
AAAGTGAAGA ACTGGATATC TTTGCCAATT CATCTTTAAA AAAATTAGAG TTGTCATCGA 720
ATCAAATTAA AGAGTTTTCT CCAGGGTGTT TTCACGCAAT TGGAAGATTA TTTGGCCTCT 780
TTCTGAACAA TGTCCAGCTG GGTCCCAGCC TTACAGAGAA GCTATGTTTG GAATTAGCAA 840
ACACAAGCAT TCGGAATCTG TCTCTGAGTA ACAGCCAGCT GTCCACCACC AGCAATACAA 900
CTTTCTTGGG ACTAAAGTGG ACAAATCTCA CTATGCTCGA TCTTTCCTAC AACAACTTAA 960
ATGTGGTTGG TAACGATTCC TTTGCTTGGC TTCCACAACT AGAATATTTC TTCCTAGAGT 1020
ATAATAATAT ACAGCATTTG TTTTCTCACT CTTTGCACGG GCTTTTCAAT GTGAGGTACC 1080
TGAATTTGAA ACGGTCTTTT ACTAAACAAA GTATTTCCCT TGCCTCACTC CCCAAGATTG 1140
ATGATTTTTC TTTTCAGTGG CTAAAATGTT TGGAGCACCT TAACATGGAA GATAATGATA 1200
TTCCAGGCAT AAAAAGCAAT ATGTTCACAG GATTGATAAA CCTGAAATAC TTAAGTCTAT 1260
CCAACTCCTT TACAAGTTTG CGAACTTTGA CAAATGAAAC ATTTGTATCA CTTGCTCATT 1320
CTCCCTTACA CATACTCAAC CTAACCAAGA ATAAAATCTC AAAAATAGAG AGTGATGCTT 1380
TCTCTTGGTT GGGCCACCTA GAAGTACTTG ACCTGGGCCT TAATGAAATT GGGCAAGAAC 1440
TCACAGGCCA GGAATGGAGA GGTCTAGAAA ATATTTTCGA AATCTATCTT TCCTACAACA 1500
AGTACCTGCA GCTGACTAGG AACTCCTTTG CCTTGGTCCC AAGCCTTCAA CGACTGATGC 1560
TCCGAAGGGT GGCCCTTAAA AATGTGGATA GCTCTCCTTC ACCATTCCAG CCTCTTCGTA 1620
ACTTGACCAT TCTGGATCTA AGCAACAACA ACATAGCCAA CATAAATGAT GACATGTTGG 1680
AGGGTCTTGA GAAACTAGAA ATTCTCGATT TGCAGCATAA CAACTTAGCA CGGCTCTGGA 1740
AACACGCAAA CCCTGGTGGT CCCATTTATT TCCTAAAGGG TCTGTCTCAC CTCCACATCC 1800
TTAACTTGGA GTCCAACGGC TTTGACGAGA TCCCAGTTGA GGTCTTCAAG GATTTATTTG 1860
AACTAAAGAT CATCGATTTA GGATTGAATA ATTTAAACAC ACTTCCAGCA TCTGTCTTTA 1920
ATAATCAGGT GTCTCTAAAG TCATTGAACC TTCAGAAGAA TCTCATAACA TCCGTTGAGA 1980
AGAAGGTTTT CGGGCCAGCT TTCAGGAACC TGACTGAGTT AGATATGCGC TTTAATCCCT 2040
TTGATTGCAC GTGTGAAAGT ATTGCCTGGT TTGTTAATTG GATTAACGAG ACCCATACCA 2100
ACATCCCTGA GCTGTCAAGC CACTACCTTT GCAACACTCC ACCTCACTAT CATGGGTTCC 2160
CAGTGAGACT TTTTGATACA TCATCTTGCA AAGACAGTGC CCCCTTTGAA CTCTTTTTCA 2220
TGATCAATAC CAGTATCCTG TTGATTTTTA TCTTTATTGT ACTTCTCATC CACTTTGAGG 2280
GCTGGAGGAT ATCTTTTTAT TGGAATGTTT CAGTACATCG AGTTCTTGGT TTCAAAGAAA 2340
TAGACAGACA GACAGAACAG TTTGAATATG CAGCATATAT AATTCATGCC TA AAAGATA 2400
AGGATTGGGT CTGGGAACAT TTCTCTTCAA TGGAAAAGGA AGACCAATCT CTCAAATTTT 2460
GTCTGGAAGA AAGGGACTTT GAGGCGGGTG TTTTTGAACT AGAAGCAATT GTTAACAGCA 2520
TCAAAAGAAG CAGAAAAATT ATTTTTGTTA TAACACACCA TCTATTAAAA GACCCATTAT 2580
GCAAAAGATT CAAGGTACAT CATGCAGTTC AACAAGCTAT TGAACAAAAT CTGGATTCCA 2640
TTATATTGGT TTTCCTTGAG GAGATTCCAG ATTATAAACT GAACCATGCA CTCTGTTTGC 2700
GAAGAGGAAT GTTTAAATCT CACTGCATCT TGAACTGGCC AGTTCAGAAA GAACGGATAG 2760
GTGCCTTTCG TCATAAATTG CAAGTAGCAC TTGGATCCAA AAACTCTGTA CATTAAATTT 2820
ATTTAAATAT TCAATTAGCA AAGGAGAAAC TTTCTCAATT TAAAAAGTTC TATGGCAAAT 2880
TTAAGTTTTC CATAAAGGTG TTAT ATTTG TTTATTCATA TTTGTAAATG ATTATATTCT 2940
ATCACAATTA CATCTCTTCT AGGAAAATGT GTCTCCTTAT TTCAGGCCTA TTTTTGACAA 3000 TTGACTTAAT TTTACCCAAA ATAAAACATA TAAGCACGTA AAAAAAAAAA AAAAAAA 3057
Seq ID NO 77 DNA Sequence Nucleic Acid Accession B Eos sequence 5 1 11 21 31 41 51
I I I I I I
ATCAAGGAGG ACAGATTTTA TATGCTTAAG ACTGGAGGGA GAGAGACCAG TTAGAAAGAC 60
TCTGGCTATA ATCCAAGCAA GCCATACTAT GGGCTGGTTT GGTGGAGGTA GAGGAATGTC 120
CAGATTGGAG AAACAGGAAG TTAAAAATGG GCAGGGCTTG CTGACTGTTT GAAACTAGGG 180 0 GGTGTGAAGG GAGGCAGCAC TCTAGGATAA ACACCAGACT TGCCGATTGT TTGGGAATAT 240
CCAATTCTGC TGTAGAAGAC AGGAAAACAA TAAACTCAAA AGAAGTGTTA CACATAGATA 300
ACTAAATTAG TCATCTGTAG ATAGTACAAC ATATTCGTGT GTACAGAGAT CAAAAGGGAC 360
AGAAAGACCA AGGAGGCACT AAATATTCAC GGTACCCTAA ATACGTGAGA CATGAGGCAC 420
TCAGGATGCA GGAGGTTTCA ATTTGACAGG ATGGATGCAC ACTGCATGAC CCACAGTTCA 480 5 GCTGGTGTGA TCATTCCACC CAACTTGCCC CCTCTCCCGT GTGTTGACCC ACCCCAGCAC 540
CTGCCTCCTG CTTCTCAGAA TGTGTTTTAC ATTTATTTAA TAAACGATGT TATTTGAGCA 600
TTTA 604
Seq ID NO 78 DNA Sequence 0 Nucleic Acid Accession tt Eos sequence
1 11 21 31 41 51
I I I I I I ττττττττττ TTTTTTTTTA AATGCTCAAA TAACATCGTT TATTAAATAA ATGTAAAACA 60
CATTCTGAGA AGCAGGAGGC AGGTGCTGGG GTGGGTCAAC ACACGGGAGA GGGGGCAAGT 120 5 TGGGTGGAAT GATCGATCAC ACCAGCTGAA CTGTGGGTCA TGCAGTGTGC ATCCATCCTG 180
TCAAATTGAA ACCTCCTGCA TCCTGAGTGC CTCATGTCTC ACGTATTTAG GGTACCGTGA 240
ATATTTAGTG CCTCCTTGGT CTTTCTGTCC CTTTTGATCT CTGTACACAC GAATACGTTG 300
TACTATC AC AGATGACTAA TTTAGTTATC TGTGTGTAAC ACTTCTTTTG AGTTTATTGT 360
TTTCCTGTCT TCTACAGCAG AATTGGATAT TCCCAAACAA TCTGCAAGTC TGGTGTTTAT 420 0 CCTAGAGTGC TGCCTCCCTT CACACCCCCT AGTTTCAAAC AGTCAGCAAG CCCTGCCCAT 480
TTTTAACTTC CTGGTTTCTC AATCTGGACA TTCCTCTACC TCCACCAAAC CAGCCCATAG 540
TATGGCTTGC TTGGATTATA GCCAGAGTCT TTCTAACTGG TCTCTCTCCC TCCAGTCTTA 600
AGCTTAAAAT CGTCTCCTTG ATT 623 5 Seq ID NO 79 DNA Sequence
Nucleic Acid Accession # Eos sequence
Coding sequence 315 1416
1 11 21 31 41 51
.„ I I I I I I U CTTCAGATAG ATTATATCTG GAGTGAAGAA TCCTGCCACC TATGTATCTG GCATAGTATT 60
CTGTGTAGTG GGATGAGCAG AGAACAAAAA CAAAATAATC CAGTGAGAAA AGCCCGTAAA 120
TAAACTTTCA GACCAGAGAT CTATTCTCTA GCTTATTTTA AGCTCAACTT AAAAGGAAGA 180
ACTGTTCTCT GATTCTTTTC GCCTTCAATA CACTTAATGA TTTAACTCCA CCCTCCTTCA 240
AAAGAAACAG CATTTCCTAC TTTTATACTG TCTATATGAT TGATTTGCAC AGCTCATCTG 300 5 GCCAGAAGAG CTGAGACATC CGTTCCCCTA CAAGAAACTC TCCCCGGGTG GAACAAGATG 360
GATTATCAAG TGTCAAGTCC AATCTATGAC ATCAATTATT ATACATCGGA GCCCTGCCAA 420
AAAATCAATG TGAAGCAAAT CGCAGCCCGC CTCCTGCCTC CGCTCTACTC ACTGGTGTTC 480
ATCTTTGGTT TTGTGGGCAA CATGCTGGTC ATCCTCATCC TGATAAACTG CAAAAGGCTG 540
AAGAGCATGA CTGACATCTA CCTGCTCAAC CTGGCCATCT CTGACCTGTT TTTCCTTCTT 600 0 ACTGTCCCCT TCTGGGCTCA CTATGCTGCC GCCCAGTGGG ACTTTGGAAA TACAATGTGT 660
CAACTCTTGA CAGGGCTCTA TTTTATAGGC TTCTTCTCTG GAATCTTCTT CATCATCCTC 720
CTGACAATCG ATAGGTACCT GGCTGTCGTC CATGCTGTGT TTGCTTTAAA AGCCAGGACG 780
GTCACCTTTG GGGTGGTGAC AAGTGTGATC ACTTGGGTGG TGGCTGTGTT TGCGTCTCTC 840
CCAGGAATCA TCTTTACCAG ATCTCAAAAA GAAGGTCTTC ATTACACCTG CAGCTCTCAT 900 5 TTTCCATACA GTCAGTATCA ATTCTGGAAG AATTTCCAGA CATTAAAGAT AGTCATCTTG 960
GGGCTGGTCC TGCCGCTGCT TGTCATGGTC ATCTGCTACT CGGGAATCCT AAAAACTCTG 1020
CTTCGGTGTC GAAATGAGAA GAAGAGGCAC AGGGCTGTGA GGCTTATCTT CACCATCATG 1080
ATTGTTTATT TTCTCTTCTG GGCTCCCTAC AACATTGTCC TTCTCCTGAA CACCTTCCAG 1140
GAATTCTTTG GCCTGAATAA TTGCAGTAGC TCTAACAGGT TGGACCAAGC TATGCAGGTG 1200 0 ACAGAGACTC TTGGGATGAC GCACTGCTGC ATCAACCCCA TCATCTATGC CTTTGTCGGG 1260
GAGAAGTTCA GAAACTACCT CTTAGTCTTC TTCCAAAAGC ACATTGCCAA ACGCTTCTGC 1320 AAATGCTGTT CTATTTTCCA GCAAGAGGCT CCCGAGCGAG CAAGCTCAGT TTACACCCGA 1380 TCCACTGGGG AGCAGGAAAT ATCTGTGGGC TTGTGACACG GACTCAAGTG GGCTGGTGAC 1440 CCAGTCAGAG TTGTGCACAT GGCTTAGTTT TCATACACAG CCTGGGCTGG GGGTGGGGTG 1500 5 GGAGAGGTCT TTTTTAAAAG GAAGTTACTG TTATAGAGGG TCTAAGATTC ATCCATTTAT 1560
TTGGCATCTG TTTAAAGTAG ATTAGATCTT TTAAGCCCAT CAATTATAGA AAGCCAAATC 1620 AAAATATGTT GATGAAAAAT AGCAACCTTT TTATCTCCCC TTCACATGCA TCAAGTTATT 1680 GACAAACTCT CCCTTCACTC CGAAAGTTCC TTATGTATAT TTAAAAGAAA GCCTCAGAGA 1740 ATTGCTGATT CTTGAGTTTA GTGATCTGAA CAGAAATACC AAAATTATTT CAGAAATGTA 1800
70 CAACTTTTTA CCTAGTACAA GGCAACATAT AGGTTGTAAA TGTGTTTAAA ACAGGTCTTT 1860
GTCTTGCTAT GGGGAGAAAA GACATGAATA TGATTAGTAA AGAAATGACA CTTTTCATGT 1920 GTGATTTCCC CTCCAAGGTA TGGTTAATAA GTTTCACTGA CTTAGAACCA GGCGAGAGAC 1980 TTGTGGCCTG GGAGAGCTGG GGAAGCTTCT TAAATGAGAA GGAATTTGAG TTGGATCATC 2040 TATTGCTGGC AAAGACAGAA GCCTCACTGC AAGCACTGCA TGGGCAAGCT TGGCTGTAGA 2100
75 AGGAGACAGA GCTGGTTGGG AAGACATGGG GAGGAAGGAC AAGGCTAGAT CATGAAGAAC 2160
CTTGACGGCA TTGCTCCGTC TAAGTCATGA GCTGAGCAGG GAGATCCTGG TTGGTGTTGC 2220 AGAAGGTTTA CTCTGTGGCC AAAGGAGGGT CAGGAAGGAT GAGCATTTAG GGCAAGGAGA 2280 CCACCAACAG CCCTCAGGTC AGGGTGAGGA TGGCCTCTGC TAAGCTCAAG GCGTGAGGAT 2340 o n GGGAAGGAGG GAGGTATTCG TAAGGATGGG AAGGAGGGAG GTATTCGTGC AGCATATGAG 2400
80 GATGCAGAGT CAGCAGAACT GGGGTGGATT TGGTTTGGAA GTGAGGGTCA GAGAGGAGTC 2460
AGAGAGAATC CCTAGTCTTC AAGCAGATTG GAGAAACCCT TGAAAAGACA TCAAGCACAG 2520 AAGGAGGAGG AGGAGGTTTA GGTCAAGAAG AAGATGGATT GGTGTAAAAG GATGGGTCTG 2580 GTTTGCAGAG CTTGAACACA GTCTCACCCA GACTCCAGGC TGTCTTTCAC TGAATGCTTC 2640 TGACTTCATA GATTTCCTTC CCATCCCAGC TGAAATACTG AGGGGTCTCC AGGAGGAGAC 2700 TAGATTTATG AATACACGAG GTATGAGGTC TAGGAACATA CTTCAGCTCA CACATGAGAT 2760
CTAGGTGAGG ATTGATTACC TAGTAGTCAT TTCATGGGTT GTTGGGAGGA TTCTATGAGG 2820
CAACCACAGG CAGCATTTAG CACATACTAC ACATTCAATA AGCATCAAAC TCTTAGTTAC 2880
TCATTCAGGG ATAGCACTGA GCAAAGCATT GAGCAAAGGG GTCCCATAGA GGTGAGGGAA 2940
GCCTGAAAAA CTAAGATGCT GCCTGCCCAG TGCACACAAG TGTAGGTATC ATTTTCTGCA 3000
TTTAACCGTC AATAGGCAAA GGGGGGAAGG GACATATTCA TTTGGAAATA AGCTGCCTTG 3060
AGCCTTAAAA CCCACAAAAG TACAATTTAC CAGCCTCCGT ATTTCAGACT GAATGGGGGT 3120
GGGGGGGGCG CCTTAGGTAC TTATTCCAGA TGCCTTCTCC AGACAAACCA GAAGCAACAG 3180
AAAAAATCGT CTCTCCCTCC CTTTGAAATG AATATACCCC TTAGTGTTTG GGTATATTCA 3240 0 TTTCAAAGGG AGAGAGAGAG GTTTTTTTCT GTTCTTTCTC ATATGATTGT GCACATACTT 3300
GAGACTGTTT TGAATTTGGG GGATGGCTAA AACCATCATA GTACAGGTAA GGTGAGGGAA 3360
TAGTAAGTGG TGAGAACTAC TCAGGGAATG AAGGTGTCAG AATAATAAGA GGTGCTACTG 3420
ACTTTCTCAG CCTCTGAATA TGAACGGTGA GCATTGTGGC TGTCAGCAGG AAGCAACGAA 3480
GGGAAATGTC TTTCCTTTTG CTCTTAAGTT GTGGAGAGTG CAACAGTAGC ATAGGACCCT 3540
15 ACCCTCTGGG CCAAGTCAAA GACATTCTGA CATCTTAGTA TTTGCATATT CTTATGTATG 3600
TGAAAGTTAC AAATTGCTTG AAAGAAAATA TGCATC AAT AAAAAACACC TTCTA 3655
Seq ID NO- 80 DNA Sequence Nucleic Acid Accession tt Eos sequence 0 1 11 21 31 41 51
I I I I I I
GCCCCTGAAG TTAGCGGAAG GGAACGGGCA TGTTTTGGAA AGGCCCGCCG GGAATTCCCT 60
CAGAAACCAG GCGAAGCTCC CTGCTGGGCC AGGCCCCCCT CGTGTGCTTG AGGAGGATGG 120
GAGCCCGGCC TCGGTTTGTT ATCCTAATTA AGTGGAAAAT TAAGAAAATA ATAGAATAGC 180 5 GTAAGTACTA ATAGTAAAAT TATAGTAAGA GAAATAACAA TAGCTAGAAT GGAATGAATT 240
GCTGTATTAA CCAAGGCTAG AAAGAATTTC AGCCCTCCGA AAGTTAAAGC GAGGGAAGAG 300
AGAGACCCTC TCATATTGTT TTATACTCAG TACCTGTTTT TTTTTTTTTT TTTTAAAAAA 360
AGGAAGTGAA ATCAAAGACA GGCAGCCCAG CGCCAGGCCC AAAACTGGAC CTGGGCCTGC 420
CTGGCCTAAA CCTAGTAGTT AAAAATCAAC TCATGACTTA GAAACCGATG TTATTCATAG 480 0 ATTCCAGACA TTCTATAGAA GAACATTGTG AAACTCCCTG CCCTGTTCTG TTTCTCTCTG 540
ACCATCGGTG CATGCAGCCC CTGTCACGTA CCCCTTGCTT GCTCAAATCA ATCACGACCC 600
TTTCATGTGA AATTTTAGTG TTGTGAGCTC TTAAAAGCGA CAGAAATTGT GCACTCGGGG 660
AGCTCGGATT TTAAGGCAGT AGCTTGCCAA TGCTCCCAGC TGAATAAAGC CCTTTCTTCT 720
ACAGCTCCGT GTCTGAGAGG TTTTGTCTGT GGCTTGTCCT GCTACAGTCC TTGGTTCCCT 780
35 GACCAGGAAG CGAGGTGACT GACAAGCCCT GTGGAGCGTC CCTGCAGAGG ACTCCGGCCA 840
GCCTGAGTGA CGCAATCCAA AGAGCGCTCC CGGGTAGGAA ATGGCCCCGG TGGAATGCCT 900
TGCCAGAGCA GCGCATAGCA GGCTCCCGAG AAGGATTAAC ACTGGCTGAA CACCGGGAAG 960
GAACTGGCAC TTGAAGTCCA GACATCTGAA GCTTGTCAAG ACTAGTCTTT GGAACTTGCC 1020
CCACTCCATG TGAGTGGAAG CATGGCCTGA TCACCCACGG TGTGCCTGTA TTGACATCTT 1080
40 TGTTCTGGTT TTGACTTGGC TTGACTTGGT AAGACTAGTC TTTGGAACTT GCCCCACTCC 1140
ACGTGAGTGG AAGCGTGGCC TGATCACCCA CGGTGTGCCT GTATTGGCAC TTTTGTTCTG 1200
GTTTTGACTT GGCTTGACTT GGTAAGACTA GTCTTTGGAA CTTGCCCCAC TCCATCTGAG 1260
TGGAAACGTG GCCTGATCAC CCACAGCATG CCTGCATGGG CACTCTTGTT CTGGTTTTGA 1320
CTTGACTTGA ATTGCTGGAT ACTTTGGTTT TGGTTTTGAC TTGGCTTGAA TTTTTTGGTA 1380
45 CTCGGATTTT GAATTTCGTG ATTTTGGTTT GGTATAAACG GTAAAAGTGT GTGTGCCCTC 1440
TTTACCTGTT CTTTGTCTTG TGGTATGTGT GGTGTGAGCG TGGTATTTTG TCTGGAAAAA 1500
AAAAAAAAAA 1510
Seq ID NO 81 DNA Sequence J\) Nucleic Acid Access ion tt Eos sequence
1 11 21 31 41 51
I I I I I I
CGCTGCCGGG CCGGGGCTGG GCCGGAGCGG CGGCGCCTGG ATGCCGGCCC GGGGCTGGGC 60
CGGAGACTGG CGCCCGCCCC GAAGCGACTT TCGGTCCCCG ACCCGCTCCG CCTGACCCCT 120
55 ATGATGAAGA GGGCGTCCAC TGGAGTTCTT GCTGTCGACA TCTTTGACAA GTTCAACTTC 180
ACGGGAGCCA GAGTCCCATG GTTCGACGCC ATTCATGAAG AATTCCCCAG GGAGCTGGAG 240
TCCTCCATCT CCTTCCCAGC CAACTTCTTC AAACCACCTG AAGAAAAAGT GCTTAGGTAG 300
AGGTTGAGCA TCCTAATCCT GAAATCTGAA ATGCTCCAGA ATCTGAACCT TCTTGAGCAC 360
CAACCTGACA CTTAAAGGAA GTGCTCATTG GAGGATCTGT GACAATTACT AAAAACTTCC 420
60 CCAAATAAAA AGGACATGAA AAGAATCTCA CGCTATCGCC CAGGCTGGAG TGCAGTGGCG 480
CGATCTCCGC TCACTGCAAG CTCCGCCTCC CGGGTTCGCG CCATTCTCCT GCCTCAGCCT 540
CCCGAGAGTA GCTGGGACTG CAGGCGCCCG CCACCACGCC CAGCTAATTT TTTGTATTTT 600
TAGTGGAGAC GGGGTTTCAC CGTGTTGGCC AGAATGGTTT CGATCTCCTC ACCTCGCGAT 660
CCATCCGCCT CAGCCTCCCA AAGTGCTGGG ATTACAGGCG TGAGCCACCG TGCCTGGCCC 720
65 TCATGTGTCT TAAAAAGAGG GGTGACTCTG ATGTGGGGTC ATGCTTGAAA CTGAGAGGAC 780
GAGGTCCCCG ACCCTCCATT GCAGCCAGCT CTCTCTGGAA CTAACAGAGT GAGAACTCGC 840
TCATTACCAA GGGGAGGACA CCAAGCCATT CATGGGGGAC CCACCCCCAT GACCCAAACA 900
ACCCCGACCA CGCCCACCTC CAACCCTTAA GCAGTCCATC TCCAGAACTC TTTTCATCCT 960
GCAGATCTGA AACTCTAGCC CACAAAACAC CAACTCCACT CCCCAGCCAC TGGTGCCCAC 1020
70 CGTTGTTTCT GTCTCTGAAT TTGACTCCTC TAGGGACCTC CCATAAGTGG AATCATACAA 1080
TATTTGTCCT TTTGTGCTTG GCTTATTTCA CTGAGCGTAA TGTTCTCTAG GTTCACCTGT 1140
GTTGTAGCAA ACGTCAGACT TTCCCTCCTT TTGAAGGCTG AGTAATATTC TGTTGTGTGG 1200
ATGGAGCACG CATTGTTTAT CCACTCACCT GTTGACGCAT GCCTGGGTCG TTTCCACCTT 1260
TCGGCCTGTG TGAATGGTGC TGCTCTGAAC AGGGGTGAAG ACGTATCTGG GCGTCTGCTT 1320
75 TCAGTTCTTT TGGGTGTATA CCCAGAAGTG GGCTTGCTGG GTCACGTGGT AAATCCTGTG 1380
GTTGATTTTT TGAGGACGCA CCATACTGTT TTCGGTGGGA CATCTGTTGG GTTTTGAGAA 1440
GCACCTGCTG GCACTGAGAG CTGTCTTGGG GAACACAGGT GCTCCTGCCG GAGTCCTCAC 1500
GCTCTGCTCA CGTTGCAGAA GGCCCCCTGG TAAGGCCAGC CAGCCGGAGG ACCACCCCGC 1560
AGACCACACG CCCAGGGCCT GGCACCGAGG GGGAGGCCCC GATCAGCAGG TGAAAGCGAC 1620
80 ACCCTGATGA CACTGGCTAG TTCACCTTCA CTCTGGTCAT CGTTTACTGT ACCCCGGGGC 1680
AGCTCCCGCC TGAGCCCTAT GACCCCAACC GCCGCAGCCT CTGGTAAGGC CTGGGTATGG 1740
GGCACATGGA GAGGGCCCAT TCCAGAGGCT CCTAAGTCAA AAGAGATTCC ACAAGTCAAA 1800
ATCCTGATCC TGATCAAGCA CAGGCCTTCA CAGTGACATT TCACTGTGAC CCTGGCCCAG 1860
AGACAGAGAC CACTGTCCTG CAGTGTCCCT GGGAGGGAGG TTCTGGGTCT GCCACAGGAC 1920 ACCACACCCT GGAACATTGC ACACCCTTTG CCTGGCCTTT TCCCAGCGTT TCTGTCAGAA 1980
ATGCCCCCTC CCAAGCATAC ACCCCATCTT GTGCCCCGAG GGACTCGATT CTCTCCCCAC 2040
ACACCCGACC CGAGGCTGTC ATGGGTAGTG CCTGCTGCTG GCCCCAGGGT TAGGGCTGCT 2100
CAGCCAGTCC TGGCTGGAAA GGATGAATGT CCCACAAGCA GCTTTGGGGC CTGCTTGGTG 2160
GGAGCAGCCC GAGGATCCGC CCTTCGTCCT CCTGCCATTT CCCACTTCCC TGGCTCTGGG 2220
GTCCTCATGT TCACGTGGTT CTCAGTGACT GGGTGATTGA CNNNNNNNNN NNNNNNNNNN 2280
NNNNNNNGGT GTCTTTTGCT GGACATTTAA GCCATTCCTT GTGTTTCTGC CATTAGCTAT 2340
TATGGGCTGT AACATCTTTG CACCTGTGCC TTCTTTCTTT TTAAATTTCT GAAGTCCTAA 2400
TTTGACCCAA AGGTGACACA TCTCCCTGTG TGCCCTGTCA GTGATGAAAC CTGCTCTGGG 2460
GATGAAGATG CCGTGGGGCC CACAGATCCA AGCTCTCGGA GTGTGATTCT GTCTCCCCTA 2520
GAAACACATC CATGGCATGT CCTCAGGGCA TTTGTGCATG GGATTAAGCA AATGTTTCCT 2580
AATCATGTTT GTCCCTGTGC TCTGGCTTCT TGACCTCAGG CTGCCTCACT GGCCCATCAT 2640
TAATACGTCG ATGGTGAGCG CACTGGTGTA CAGCGAGGGG GCTCCACTTC CGAGCCCCCT 2700
GGAGAGGCCC GTCCTGGTGG AGTTCACCCT GCTGGAGATG GAGAAGCGAA CCAAGCCTGT 2760
CTGTGTGTTC TGGAACCATT CCCTGGCGTA AATGTGATGC CGGGAGTTCT GCATCTTCAT 2820
GTGAGGGCTT TGCCAAGACA CAGAGAACCC GCAGGGTTGT TGGCTCAGCG GCAGATCGTC 2880
CCACGGGGAC AGTCTCTTGT GGTCTGTGTC TCCCCCTTCA GCCCCCTGTG GGGCAGTTAG 2940
CCTCCTGCTC TGCTTCTGTG GGTGCATCAG AGCCCCCCCA GATGCCCACA CGCAGACGCG 3000
CACAGGCCTG CACGTGGAAA CACAGACATG CGCACACGCA GGCCCACACA CAGACGCACA 3060
CAGAGCTGCA CGTGGAGACA CGTGCGCACA CGCAGGCCCA CACGCAGGCC CACACACAGG 3120
TGCACGCGGA CCTGCACGTG GAGACACAGA TGTGTGCACA TGCAGGCCCA CACACAGGTG 3180
AGCGTGGACC TGTGTGAACA GATGCGCGCA GACCTGCACG TGGAGACACA GACATGCAGG 3240
CGCACAAAGA GATCCCTCAA GGCTGACACC CAGGAAGGGG CCTCTCACTT GTGGGACTCC 3300
CGAGATGCAG TGGCCAACAC TAGTGTAGTG CCCAGTTCAC TGCTGGATAA GACAGAGGCC 3360
TGTTCTGGTC ACACATGGGA GGCAGAACCC AGAGACTGGG CCCAGGAGCC CTTCTGCTGA 3420
CAGTGGGAAC TCCCAGCTAC GTGTGGGGGT CCCCATACCA GACAAAGGTC CCTGACCTTA 3480
GTCTTGCCCG AGAGGCCGAC ACAGCCCAGC TTTGGGGTCT GGCTTTACCC ACAAGAGGCC 3540
ACACCTTGCC ACAGCACTGT TTATCTGGCC TGTTTCAGAA GCACCGTCAG AGTGGCGAAG 3600
GCAGGAGGTG GTGCACGAGA GTCTACGTTC TAGCATCCAT TCAAGTGAGG GAAAGGCGTT 3660
TCGTACTTAG AAAAATGCAA AATTAATGAT TCTCACCCAC ACATGAGACT GTGGATTCAC 3720
CCATGTATGA GACAGTGGAT TCAGAGCCAT GCTGTGGCTC TCATCTGCTG GGAGCCAGTA 3780
GTGTTTGTGC TTTGGTTTTG TTTTTTTAGC TACATGGTTT ATGTGAGGTG CGGACTTACT 3840
TGAGTTGCTC TGTCTTTACA GGGAGCTTGC TTTTTCTCTG CTGGTTTGTT TTCACTTTTG 3900
CTGTCTCTGT TTAGAAGAAA ACATTAGAAC TGGGGTGTGG TGGAAGGATG GGAGCACAAT 3960
CTGGGAGGGG AAGACCTGCT CTCTCTCCAC ATACCAGGAG GGAGTGGCAG GAAGGGGAGA 4020
CACTGTGCCG GACTCAGGGA GTCAAGAGCG TGAGCACCCC CAGGCTTCAA TCTGCTGAAC 4080
GTTGTGCATC TGGGGGCGCC CGTGCAGCAG GAACACTCTC CCCATCACAA TTCCTCTGGG 4140
CACAGTGGAG AGCCATGAGT GGGGGCTGTC CTGGGGGCTG CGCTATGGTG AGTGAGCCCA 4200
CGCCAGGAGC CAGTTCAGCC CAGCCTCATT CTTCTCCTGC TTCTTTGCTT TCCAAGTTCT 4260
AGTTCATAAG CAACCAGCAC AGTACCTGGA ATGTAAGAGG CGCTTGGCTT ATAAAAGAGA 4320
GAAGAAAGGA ACCCCTTTCA CCACGAGGGA CGTCAGGCCC AGCTCTCTGT CCCGGGCATT 4380
CATCTTTTTT CCGGCAATTA GCTTCAGCTC TAATGACCTG CTGTCTGCTT TATGTTGCAC 4440
CTATGATTTC CAGATTGTAA AGTTTGTGGC AAATGTATTA ACGTTCACAT CCCATTTACA 4500
GATTAGCAAA CTAAGGATCT GAGAGGTTAT GTGATTTTCC CAGTCTGGCG GAGGGCAGGG 4560
CCCTGTCAGA AGCCGAGACA CACCTCGTAA CAGCTTGTTA TTTGGGGCTT CCCATCAGTG 620
AGGCAGGAGT CATAATGGGG CCCTGGCTTC TGGGCAATTC CCATAAAACA TTGTGCCACC 4680
TGAAGATGGA AGTGTCAGAG GAAGGCGAGA TGTTATTTCT GAAAGCATCT ACCCTCAGAA 4740
AGAGACAGAG GAGTGCATCG CAGCTGTGTG AACCCGGGGT GGTGGTGGTT CCAGCAGCGG 4800
GGCACGTGGT GGACGCAAGA CGGCCCCGTT TGAGTTTTGC TGCTAGGTGA CACGTAGAAC 4860
TTGAACTTCA GAGGGTGCTC CTTGGGGGCC CTGATGAGAG AGACACAGAA GGGAAGGGAG 4920
ACTGTTCCCA TGGTCCTGCC TCTGCGGCAG CGAGCCTGCT GCTCTTGCAG CTGGGTGGCT 4980
GTTCGGTGCA GGGGGCCGGT GAGGAACACG GTGGGGAGCA GCCTGCGAGG GCGCCGGGCT 5040
TTCAGCACTC ACTATACCTG CTGTTTGGTT TGGCCAGGAT GGCCTGGGAG TCCCCAGGGC 5100
CGGGCAAAGA CTGCCCCCAA CAGACATGGG CGGAGGGAAC CGTCTCACCC CTGCCTCTTC 5160
TCCCTTCTCT ACGCAGTGTC AGTGGGACGG GAGGGTGGTC TGCCCGGGGC TTCAAGCTCC 5220
TGTCCAGGAA CCGGACCCAT GTCGTACGCC AGTGCAGCCA CACGGCCAGC TTCGAGGTGC 5280
TCATGGACGT CTCCAGGTGT GAGATGGGCA TCTTCTTGTG GCCACTATGC CCGCTGAGCC 5340
TACCCCCAAA CCTGCCCCTC CTCAAACTAA ATCTTCCATT CTAAGCACTT TGAACGAAGC 5400
AAATCAACCA ATTAAAAAAA TATATTCCAG GAAAAAAAAA AAAAAAAAAA AAAAAAAACA 5460
AAA 5463
Seq ID NO 82 DNA Sequence
Nucleic Acid Accession tt Eos sequence
Coding sequence 651
1 11 21 31 41 51
I I I I I I
CCACAGGGGC CCCCAGGGCC ACCAGGGATC CCTGGAGCCA AGGGCGAGCT TGGATTGCCC 60
GGTGCCCCAG GAATCGATGG AGAGAAGGGC CCCAAAGGAC AGAAAGGAGA CCCAGGAGAG 120
CCTGGGCCAG CAGGACTCAA AGGGGAAGCA GGCGAGATGG GCTTGTCCGG CCTCCCGGGC 180
GCTGACGGCC TCAAGGGGGA GAAGGGGGAG TCGGCATCTG ACAGCCTACA GGAGAGCCTG 240
GCTCAGCTCA TAGTGGAGCC AGGGCCCCCT GGCCCCCCTG GCCCCCCAGG CCCGATGGGC 300
CTCCAGGGAA TCCAGGGTCC CAAGGGCTTG GATGGAGCAA AGGGAGAGAA GGGTGCGTCG 360
GGTGAGAGAG GCCCCAGCGG CCTGCCTGGG CCAGTTGGCC CACCGGGCCT TATTGGGCTG 420
CCAGGAACCA AAGGAGAGAA GGGCAGACCC GGGGAGCCAG GACTAGATGG TTTCCCTGGA 480
CCCCGAGGAG AGAAAGGTGA TCGGAGCGAG CGTGGAGAGA AGGGAGAACG AGGGGTCCCC 540
GGCCGGAAAG GAGTGAAGGG CCAGAAGGGC GAGCCGGGAC CACCAGGCCT GGACCAGCCG 600
TGTCCCGTGG GCCCCGACGG GCTGCCTGTG CCTGGCTGCT GGCATAAGTG ACCCACAGGC 660
CCAGCTCACA CCTGTACAGA TCCGTGTGGA CATTTTTAAT TTTTGTAAAA ACAAAACAGT 720
AATATATTGA TCTTTTTTCA TGGAATGCGC TACCTGTGGC CTTTTAACAT TCAAGAGTAT 780
GCCCACCCAG CCCCAAAGCC ACCGGCATGT GAAGCTGCCG GAAAGTGGAC AGGCCAGACC 840
AGGGAGATGT GTACCTGAGG GGCACCCTTG GGCCTGGGCT TTCCCAGGAA GGAGATGAAG 900
GTAGAAGCAC CTGGCTCGGG CAAGGCTAGA AAGATGCTAC GTTGGGCCTT CAGTCACCTG 960
ATCAGCAGAG AGACTCTCAG CTGTGGTACT GCCCTGTAAG AACCTGCCCC CGCAAAACTC 1020
TGGAGTCCCT GGGACACACC CTATCCAAGA AGACCCAGGG GTGGAACAGC GGCTGCTGTT 1080 GCTCCTGGCC TCATCAGCCT CCAAACTCAA CCACAACCAG CTGCCTCTGC AGTTGGACAA 1140
GACTTGGCCC CCGGACAAGA CTCGCCCAGC ACTTGCGGCT GGGCCCGGGG AGCAGTGAGT 1200
GGAAATCCCC CACGAGGGTC TAGCTCTACC ACATTCAGGA GGCCTCAGGA GGCCAGCCTG 1260
CCATGAGAGC ACATGTCCTC TGGCCAGGAG TAGTGGCTGA GCTCTGTGAT CGCTGTGATG 1320 TGGACCCAGC TCCAGGGAGC AGAGTGTCGA GGATGGAGGG GCCCAGCCTG GACTGACTGC 1380
TACTTCCTGT CTCTGTTTCC ATTATCACCC AGAGAGGGAC AAGATAGGAC ATGGCCTGGA 1440
CCAGGGAGGC AGGCCTCCCA CTCAGAGTCT GGGTCTCACT GGCCCCAAGT CTCCCACCCA 1500
GAACTCTGGC CAAAAATGGC TCTCTAGGTG GGCTGTGCAG GCAAAGCAAA GCTCAGGGCT 1560
GGTTCCCAGC TGGCCTGAGC AGGGGGCCTG CCACCAGACC CACCCACGCT CTGACGAGAG 1620 GCTTTTCCAC CTCCAGCAAG TGTTCCCAGC AACCAGCTCC ATCCTGGCTG CTTGCCTTCC 1680
ATTTCCGTGT AGATGGAGAT CACTGTGTGT AATAAACCAC AAGTGCGTGT C 1731
Seq ID NO 83 DNA Sequence
Nucleic Acid Accession tt Eos sequence
1 11 21 31 41 51
I I I I I I
CCACAGGGGC CCCCAGGGCA CCAGGGATCC CTGGAGCCAA GGGCGAGCTT GGATTGCCCG 60
GTGCCCCAGG AATCGATGGA GAGAAGGGCC CCAAAGGACA GAAAGGAGAC CCAGGAGAGC 120
CTGGGCCAGC AGGACTCAAA GGGGAAGCAG GCGAGATGGG CTTGTCCGGC CTCCCGGGCG 180 CTGACGGCCT CAAGGGGGAG AAGGGGGAGT CGGCATCTGA CAGCCTACAG GAGAGCCTGG 240
CTCAGCTCAT AGTGGAGCCA GGGCCCCCTG GCCCCCCTGG CCCCCCAGGC CCGATGGGCC 300
TCCAGGGAAT CCAGGGTCCC AAGGGCTTGG ATGGAGCAAA GGGAGAGAAG GGTGCGTCGG 360
GTGAGAGAGG CCCCAGCGGC CTGCCTGGGC CAGTTGGCCC ACCGGGCCTT ATTGGGCTGC 420
CAGGAACCAA AGGAGAGAAG GGCAGACCCG GGGAGCCAGG ACTAGATGGT TTCCCTGGAC 480
CCCGAGGAGA GAAAGGTGAT CGGAGCGAGC GTGGAGAGAA GGGAGAACGA GGGGTCCCCG 540
GCCGGAAAGG AGTGAAGGGC CAGAAGGGCG AGCCGGGACC ACCAGGCCTG GACCAGCCGT 600
GTCCCGTGGG CCCCGACGGG CTGCCTGTGC CTGGCTGCTG GCATAAGTGA CCCACAGGCC 660
CAGCTCACAC CTGTACAGAT CCGTGTGGAC ATTTTTAATT TTTGTAAAAA CAAAACAGTA 720
ATATATTGAT CTTTTTTCAT GGAATGCGCT ACCTGTGGCC TTTTAACATT CAAGAGTATG 780
CCCACCCAGC CCCAAAGCCA CCGGCATGTG AAGCTGCCGG AAAGTGGACA GGCCAGACCA 840
GGGAGATGTG TACCTGAGGG GCACCCTTGG GCCTGGGCTT TCCCAGGAAG GAGATGAAGG 900
TAGAAGCACC TGGCTCGGGC AAGGCTAGAA AGATGCTACG TTGGGCCTTC AGTCACCTGA 960
TCAGCAGAGA GACTCTCAGC TGTGGTACTG CCCTGTAAGA ACCTGCTCCC GCAAAACTCT 1020
GGAGTCCCTG GGACACACCC TATCCAAGAA GACCCAGGGG TGGAACAGCG GCTGCTGTTG 1080
CTCCTGGCCT CATCAGCCTC CAAACTCAAC CACAACCAGC TGCCTCTGCA GTTGGACAAG 1140
ACTTGGCCCC CGGACAAGAC TCGCCCAGCA CTTGCGGCTG GGCCCGGGGA GCAGTGAGTG 1200
GAAATCCCCC ACGAGGGTCT AGCTCTACCA CATTCAGGAG GCCTCAGGAG GCCAGCCTGC 1260
CATGAGAGCA CATGTCCTCT GGCCAGGAGT AGTGGCTGAG CTCTGTGATC GCTGTGATGT 1320
GGACCCAGCT CCAGGGAGCA GAGTGTCGGG GATGGAGGGG CCCAGCCTGG ACTGACTGCT 1380
ACTTCCTGTC TCTGTTTCCA TTATCACCCA GAGAGGGACA AGATAGGACA TGGCCTGGAC 1440
CAGGGAGGCA GGCCTCCCAC TCAGAGTCTG GGTCTCACTG GCCCCAAGTC TCCCACCCAG 1500
AACTCTGGCC AAAAATGGCT CTCTAGGTGG GCTGTGCAGG CAAAGCAAAG CTCAGGGCTG 1560
GTTCCCAGCT GGCCTGAGCA GGGGGCCTGC CACCAGACCC ACCCACGCTC TGACGAGAGG 1620
CTTTTCCACC TCCAGCAAGT GTTCCCAGCA ACCAGCTCCA TCCTGGCTGC TTGCCTTCCA 1680
TTTCCGTGTA GATGGAGATC ACTGTGTGTA ATAAACCACA AGTGCGTGAA AAAAAAAAAA 1740
AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AG 1782
Seq ID NO 84 DNA Sequence
Nucleic Acid Accession tt Eos sequence
1 11 21 31 41 51
I I I I I I
TCCCTGAAGT GGCTGCTATC CAGGATGACT GTGTTGCTGC AGTCTTTGAG TGGTTGGAGC 60
GCTGTAATGT CTATGTTAAT AGCTGGGAAA TCGCAGTAGC AGCAACCAGA CCACTCCAAT 120
GGAACAATCC AAGTTGGGGT AAGTTTGATT GAGCAAAAAA GTCATGCTGA CTGTGTGATG 180
AAGAGGCAGA ACTGGTAACA GTGACAGGCC CTGCAGTCAG CAGCTGTGGA TTTTATGTGC 240
AGGGCAGACT GATCTGGAAA ATGGGAAGAG CTGACTGCCA ATAACACCTT GGGGGGAGGT 300
TTGTTCAGTG CATCTCCCTA CTCCTTGTAT ACCTCTGATG ACATGCAGAA GCTTAGGAAA 360
TAAAACACAC TTGTAACATC ACAGGGTGCA AGTAAGTACA TGTGGATGCC AGTGTAGAGA 420
GAAGCGAAAG CTAGTTTTCA TTGCAAGAAT CCAAACAGAG TAACAGGGCT TTGTCCACTG 480
TCTCCAGTCC ATGGTTCCCT GGTGTTCCTA GAGTCCTATT AAAAAAAAAA AAAAAAAAA 539
Seq ID NO 85 DNA Sequence
Nucleic Acid Accession tt NM_004861 1
Coding sequence 204 1475
1 11 21 31 41 51
I I I I I I
GGCAGCCTGG GAGTTGGACG TGGCTCAGGC AGTGGGTAGA AAGGGGCAGC CAGCCACAGC 60
CCGAGGGTCT CACTGTGTCA TCCAGAGCTG GAGTGCAGCG GCACAGTCAT GGCTCACTGG 120
AACTCAGGCT CAAGCAATCC TCCCGCCTCA GCCTTCCAAG TAACTAGGAC TACAGGCATG 180
TGCCACCACG CCTGGTGTCT GAGATGCTGC CACCGCAGAA GAAGCCCTGG GAGTCCATGG 240
CTAAGGGGCT GGTGCTGGGC GCGCTCTTCA CTAGTTTCCT GCTGCTGGTG TACTCCTATG 300
CCGTGCCCCC GCTGCATGCC GGCCTGGCCT CCACGACCCC GGAGGCCGCA GCGTCCTGCT 360
CTCCACCTGC ACTCGAGCCA GAGGCAGTGA TCCGGGCCAA CGGCTCGGCG GGGGAGTGCC 420
AGCCGCGGCG CAACATCGTG TTCTTGAAGA CGCACAAGAC GGCCAGCAGC ACCCTGCTCA 480
ACATCCTGTT CCGCTTCGGC CAGAAGCACC GGCTCAAGTT CGCCTTCCCT AACGGCCGCA 540
ATGACTTCGA CTACCCGACC TTCTTCGCCC GCAGCCTGGT GCAGGACTAT CGGCCCGGGG 600
CCTGCTTCAA CATCATCTGC AACCACATGC GCTTCCACTA CGACGAGGTG CGCGGCCTGG 660
TGCCGACCAA CGCCATCTTC ATCACGGTGC TCCGCGACCC CGCCCGCTTG TTCGAGTCCT 720
CCTTCCACTA CTTCGGGCCG GTGGTGCCCC TCACGTGGAA GCTCTCGGCC GGCGACAAGC 780
TGACCGAGTT CCTGCAAGAC CCGGATCGCT ACTACGACCC CAACGGCTTC AATGCCCACT 840
ACCTCCGAAA CCTGCTCTTC TTCGACCTGG GCTATGACAA CAGCCTGGAC CCCAGCAGCC 900
CGCAGGTGCA GGAGCACATC CTGGAGGTGG AGCGTCGCTT CCACCTGGTG CTCCTTCAAG 960
AGTACTTCGA CGAGTCGCTG GTGCTGCTGA AGGACCTGCT GTGCTGGGAG CTGGAGGACG 1020
TGCTCTACTT CAAGCTCAAC GCCCGCCGCG ACTCGCCCGT GCCGCGGCTC TCGGGGGAGC 1080 TGTATGGGCG CGCCACCGCC TGGAACATGC TGGACTCCCA CCTCTACCGC CACTTCAACG 1140
CCAGCTTCTG GCGCAAGGTG GAGGCCTTCG GGCGGGAGCG CATGGCCCGC GAGGTGGCCG 1200
CCCTGCGCCA TGCCAACGAG CGCATGCGGA CCATCTGCAT CGACGGGGGC CACGCCGTGG 1260
ACGCCGCCGC CATCCAGGAC GAGGCCATGC AGCCCTGCCA GCCGCTGGGC ACCAAGTCCA 1320 TCCTGGGCTA CAACCTCAAG AAGAGCATCG GGCAGCGGCA CGCGCAGCTC TGCCGGCGCA 1380
TGCTCACGCC CGAGATCCAG TACCTGATGG ACCTCGGCGC CAACCTGTGG GTCACCAAGC 14 0
TCTGGAAGTT CATTCGCGAT TTCCTGCGGT GGTGACGTCC CACCGCCCAG CGGCTTGCCT 1500
GCCTGCTCGC TCCCTGCAGA GGGGCTGAGC AGGACGCCGC TGGTGCTGGC CGCCCCCAGC 1560
CCCCTCCTGG TGCCACCTCA GACCCCGGGG TGAGGGGGGG CTCCCTGGGG GGAGGCAGCC 1620 AGCCAAGACT GGGCCCATGA ACACAGAGAG GGCCTAACCG AGATCAGTAT TTAACTAATT 1680
ATACCAGTTT TTATTAAACC CCTTTCCCTC CCCGATAAAG AATGTTCTAT TTCTGCCTCC 1740
CCTTAAAGGG GAGACCTCAG AAGTAAAGGA ATTTGATGTT GTGTTTTTGT T 1791
Seq ID NO: 86 DNA Sequence Nucleic Acid Accession tt : Eos sequence Coding sequence: 337..1878 1 11 21 31 41 51
I I I I I I
CTGCACAGGG AGTTTGTCTT GTGCAAACAA TTTCCAAGGC AGCGTTTTCT TCCCTGCCTG 60
GGAGTGCAGG GCTCAGCGCC TTCACTTTGG AACTGACTCA GAGACCTAAA GAAGCCCACC 120
TGGCCAGCGG GAAGGGGGGC CGCCGCCGCC TCCCGGTTTT GGGCAGCCCT GGCCAGCTCC 180
CTGTGGCCTT GGAGGACTTC CACCGGGCAG GCGTTCCCAT GATGCCAGGC TACCAGGCGC 240
GGGGGATTCC TGCAGGCCGG CGCTGCTTTT CTTAGAACCC CCTTTCTAGA AAAGTACACC 300
TGGAGGTTTT GCTTCAAAGA GAGGAGAGGC AGCAGCATGG CGAGTGTCCT GTCCCGACGC 360
CTTGGAAAGC GGTCCCTCCT GGGAGCCCGG GTGTTGGGAC CCAGTGCCTC GGAGGGGCCC 420
TCGGCTGCCC CACCCTCGGA GCCACTGCTA GAAGGGGCCG CTCCCCAGCC TTTCACCACC 480
TCTGATGACA CCCCCTGCCA GGAGCAGCCC AAGGAAGTCC TTAAGGCTCC CAGCACCTCG 540
GGCCTTCAGC AGGTGGCCTT TCAGCCTGGG CAGAAGGTTT ATGTGTGGTA CGGGGGTCAA 600
GAGTGCACAG GACTGGTGGA GCAGCACAGC TGGATGGAGG GTCAGGTGAC CGTCTGGCTG 660
CTGGAGCAGA AGCTGCAGGT CTGCTGCAGG GTGGAGGAGG TGTGGCTGGC AGAGCTGCAG 720
GGCCCCTGTC CCCAGGCACC ACCCCTGGAG CCCGGAGCCC AGGCCCTGGC CTACAGGCCC 780
GTCTCCAGGA ACATCGATGT CCCAAAGAGG AAGTCGGACG CAGTGGAAAT GGATGAGATG 840
ATGGCGGCCA TGGTGCTGAC GTCCCTGTCC TGCAGCCCTG TTGTACAGAG TCCTCCCGGG 900
ACCGAGGCCA ACTTCTCTGC TTCCCGTGCG GCCTGCGACC CATGGAAGGA GAGTGGTGAC 960
ATCTCGGACA GCGGCAGCAG CACTACCAGC GGTCACTGGA GTGGGAGCAG TGGTGTCTCC 1020
ACCCCCTCGC CCCCCCACCC CCAGGCCAGC CCCAAGTATT TGGGGGATGC TTTTGGTTCT 1080
CCCCAAACTG ATCATGGCTT TGAGACCGAT CCTGACCCTT TCCTGCTGGA CGAACCAGCT 1140
CCACGAAAAA GAAAGAACTC TGTGAAGGTG ATGTACAAGT GCCTGTGGCC AAACTGTGGC 1200
AAAGTTCTGC GCTCCATTGT GGGCATCAAA CGACACGTCA AAGCCCTCCA TCTGGGGGAC 1260
ACAGTGGACT CTGATCAGTT CAAGCGGGAG GAGGATTTCT ACTACACAGA GGTGCAGCTG 1320
AAGGAGGAAT CTGCTGCTGC TGCTGCTGCT GCTGCCGCAG GCACCCCAGT CCCTGGGACT 1380
CCCACCTCCG AGCCAGCTCC CACCCCCAGC ATGACTGGCC TGCCTCTGTC TGCTCTTCCA 1440
CCACCTCTGC ACAAAGCCCA GTCCTCCGGC CCAGAACATC CTGGCCCGGA GTCCTCCCTG 1500
CCCTCAGGGG CTCTCAGCAA GTCAGCTCCT GGGTCCTTCT GGCACATTCA GGCAGATCAT 1560
GCATACCAGG CTCTGCCATC CTTCCAGATC CCAGTCTCAC CACACATCTA CACCAGTGTC 1620
AGCTGGGCTG CTGCCCCCTC CGCCGCCTGC TCTCTCTCTC CGGTCCGGAG CCGGTCGCTA 1680
AGCTTCAGCG AGCCCCAGCA GCCAGCACCT GCGATGAAAT CTCATCTGAT CGTCACTTCT 1740
CCACCCCGGG CCCAGAGTGG TGCCAGGAAA GCCCGAGGGG AGGCTAAGAA GTGCCGCAAG 1800
GTGTATGGCA TCGAGCACCG GGACCAGTGG TGCACGGCCT GCCGGTGGAA GAAGGCCTGC 1860
CAGCGCTTTC TGGACTGAGC TGTGCTGCAG GTTCTACTCT GTTCCTGGCC CTGCCGGCAG 1920
CCACTGACAA GAGGCCAGTG TGTCACCAGC CCTCAGCAGA AACCGAAAGA GAAAGAACGG 1980
AAACACGGAG TTTGGGCTCT GTTGGCTAAG GTGTAACACT TAAAGCAATT TTCTCCCATT 2040
GTGCGAACAT TTTATTTTTT AAAAAAAAGA AACAAAAATA TTTTTCCCCC TAAAATAGGA 2100
GAGAGCCAAA ACTGACCAAG GCTATTCAGC AGTGAACCAG TGACCAAAGA ATTAATTACC 2160
CTCCGTTTCC CACATCCCCA CTCTCTAGGG GATTAGCTTG TGCGTGTCAA AAGAAGGAAC 2220
AGCTCGTTCT GCTTCCTGCT GAGTCGGTGA ATTCTTTGCT TTCTAAACTC TTCCAGAAAG 2280
GACTGTGAGC AAGATGAATT TACTTTTCTT AAAAAAAAAA AAAAAAAAAA AAAAAAAGAG 2340
TTTCTGGCTG ATGGGTGACT CAGAGTGCAG GACTGCCTGG CCGTGGGGCA GAGGGGTTTG 2400
CCCTTCTCGG AGGGTACCTC CTGTTCCCTG TCTGAGCATC CTGCATGGAA GTCAAAGGAA 2460
ATCCCTTTCT TGGTGACGAC TTAAATCTGG GTTCCCTCAG ACATTGGGTT GCACCCCAAC 2520
AAATATTAAA TGGCTTCTTC TTAAAGCCCA GAGAAAGAGG TTTTTTAAAA GACTGTCGCC 2580
AAATAGCTGA GCCAAAAGGC TGATCAGAAT TCACTTTTTG GAATGTGGCA GTTAAACACT 2640
ACCTTGATCA TTCTCTCCTC TTTCCTCGAG GAACTCCTGG AGGGTTTGAG CGTCTGGAAA 2700
CTCTCTGCTC TGACCCGAGG AAGCACCCTC CTGACGCCGC CTTCCTCCGG TTATTGAAAG 2760
GACGCCTCAG AAATGCTTTG TTTTCTTTTA CGATGTATTC AGAAGCCTTT ACTGATTAAA 2820
GTTTTCTTTT ATTTGGGTGG CCGGGAGAGA CCCAGGGAGG TTCTGGAGGT TCCTTTCTGT 2880
CTCCTGGCCC CACCAGGGAT TTCCCCATTT CTGTTTGCTG CCTGAAAGCA GGATGAGGAA 2940
GGCCAAGGAG AGTCCTTGCA CCCGTGAGCG TCAGGATGAG GAAATGACAG GAGGAAGACG 3000
TGGGTTTGGG TTAGTGGCTG CTGGCGTTTT GGCCCTTGGT GTTTCTGGAG CCTCCAGGGA 3060 TCTAGGGGAG CCTGGGCTGC GTGCATGTCG ATAAGCAGAG CTGTTCTTGG GGAGAAGGAG 3120 GGAGGTCTCG GGAGTGTAGC ACCATGCCAA CCAGCCCTGC GCGAAGACAG AGTGAGCCAC 3180 GCCCGGATGG CAGGGCATGT TTCTGTTTTG GTGTCTCACT TTCCTCCCAG CGTGACTTAT 3240
TTGGGGATTC CTCAGGGCCT ACTGGAATGT GACTGCCCAC TGCCCAGCTG CCTCGGGTAC 3300
AAGTCCTGGC CCTATGTCCC AGCTGTCAGG GGCTCAGGGA ATCCTACCCA GCCACCTGTC 3360 CTGGGATGGA GTGTCAGCAT CCACCCCTTG GTTGTCATCG AGGCCGCCCT CCCAGTCCTG 3420 GGTGAAGATA TTTGGGCCAC CAGGGCTCCC TTGGCCCCTT CACGTAGGAA ATAGACACGT 3480 GCTTTTTAAT GCAGGACACT TTGAGTGTTA CAAAATCTGT AGACCTGGCA GTAGGGTCAT 3540 GATGTTGGGA AGGGTGTAGT GCCCTAGGTT GGTGACAGAA GGGACAGACA CTTGTGCACA 3600 GGTGTCTTTG GTGATGGGGT TTTTTTTTTT ATAACTTAGT AAAAAAAAAA AAATGTATGT 3660 GGAATTCTGT CTCTTGGTAA AGCTCAAAGC CAGGCTAGCC TGAGGTGGCG CAGGGCTCTC 3720 CTTCCTGTCC CTTCGATCTC CTTGAGAATT AAGAGCTGGC AGCTGCTGAT GGTGTTTCCC 3780 AACCCCCCTC ACTTCCCAAG ACAACCCCCA GCTTCAGGTC CTCATGGGGA GGGGAGGGCA 3840 CGTTCTTGAC ACATGGGAAC TTCGCTCAGG AGGGCCTCCC CTTCCCCTCT CCCTCAGAGT 3900 TTTCACTGCC GTCTCGTCTT TAGAAAGCTG TTTGAATTCC CCCCGCCCCC AGTTTGGACC 3960 GTGTAGATAT AACTGGATAT ACGGATTTTT CTCTTTGTGC AGGCTTCTTA TGCCGTTGGT 4020
ATACAGGGCA GGAAAGAGAG GAATAAAGGG AGAGAGCAGT GTGGAAACCA CGGTGGTTTT 4080
GCTTTGTTCT TACTAGGTTT TGGTGCCACC TTCCCTGCCT GCGCTTGTGC CCCCTCTCCT 4140
CCTTGGCACT GGCGGCCTCC TTGCCTCCCT TCCACCCGTG CTGCCATCCC GTGCCTGTCG 4200
TGTTGGTTCT TCACACGTGC TCTGTTCTCG GGGTTGTTCC ATTCATGCCT TCTTGGAGGG 4260
TGAGGGTGGC TTGGGAACCG ACCCAGTGAT CATGCCTACT TTCTTCTTTG TATCTCCCTC 4320
CTTCCCAGCC CACCCGGGCA GCAGACTCTG ATGGAAGGAA GGTGCCGTAG GTGGGCTTTT 4380
AGAAACTAAC GGGACTGGTT TTCAAAGCAG TTATCTTGGG AAACTGTTTA TTCCAGCGAT 4440
GTGACTTTTT TCAGAATATT TCTTGGAATC ATATTCAGAG TCTGGGGCTG TGTGTTGAGC 4500
AGCCTTAAGG ATGCTAGACA CTCATTTAGT GCCCAGGGAG TCCAGCGAAT GACGTCTGTG 4560
GCCAAGCGAG GTCTCAGGTG CAAAGCAAAA GGACCATTTA AAGTAAAATA GCTTGGATTC 4620
AATCATGTGA CTTTTAAATT GGCTCAGAAA GCAATTTTGT AATTTCAGAG AGTGTTTTGA 4680
GCCATGGCCA CGTTGTCATT GTGAGTCTAT AGCTTGACTC CTTGGAGAAC AATATTCATT 4740
TGGTTGTGGA GACTGATTTG CTGGGAGAAA TCTGTCCTGT TACTTTCTGG TCATCCCAGG 4800
TTCTGACTTT TACCAGGGGC AAAAAAAAAA AAAGCAAGAG GGAGATAAAT CCCATCTGTG 4860
AGTTTGTCTT ATTGGCGCCT TTTTCCTCAG CTGTCTTCCA AGTATTATTT TTACTGTTAA 4920
AAAATTTTTT AAAAATGTGA AATGTAATGT TTTTACAGCA ACAATATGAA ATATA 497S
Seq ID NO: 87 DNA Sequence
Nucleic Acid Accession it : Eos sequence
1 11 21 31 41 51
I I I I I I
AGTGTGAAGG GAAGGCTAAG GACGCATCGG TGCTGGAGAG TTGAGAATAT GCCTTCCCCT 60
CCACCCCCAA CCCAGTCACC TTATTTGAAA AAAAATTAAA AAACACCTTT TATTTAAAAA 120
CCTAACCCTG GAAGTTTGCT CGGGAAGGCA TTCTCTTCCT CTTCCTCCAG CTGCCTGAAA 180
ATCATATGCG TGGTTTTTCC TGTTTCCTGC TCTGTAGCTG ACATCAGGGG AGCAACGTGA 240
ACACAGGAAA ATGGAAATCA ACATTTGAAA CTTTTAAATG GAAGCTTTAT TGGGGTTCCA 300
CATATGGAAA ACTGCAAATA GCAGAAGTAT GTGACTCAAT AAATTATTCT GGAGTGACCA 360
CATCCTCTAA CTGCCTCCCA GGACAAGACG GAGAATGTGA ACAATGCTCC TGAAGGCCCC 420
TTTCCCTCAA AGAATCACTG CAATTGAAGG AAAAATGCTC CATGTCCCCT CTGCCAGTTG 480
GTGTTTATCA AAGGACAACG GAGGAAGAGA GACAAAGTGC CTGGATGTGT GTGTTAATCA 540
AGAGTTGTCA GGACCCTGCC TCTAAAAGAA AGCGCTAAAA .TGATGCTTTT GACAAGACTT 600
TTCTCAAAGT GGATGCAGTC TAAGGGTTGG AAAACAAGGC CCAATCAGGC TAGGTCTGAC 660
TTGTCGCCTG CTTTTGTAAA TAAAGTTTTA TTGGCTCACA GA 702
Seq ID NO: 88 DNA Sequence
Nucleic Ac d Accession H : Eos sequence
1 11 21 31 41 51
I I I I I I
AGTGTGAAGG GAAGGCTAAG GACGCATCGG TGCTGGAGAG TTGAGAATAT GCCTTCCCCT 60
CCACCCCCAA CCCAGTCACC TTATTTGAAA AAAAATTAAA AAACACCTTT TATTTAAAAA 120
CCTAACCCTG GAAGTTTGCT CGCTGCCTGA AAATCATATG CGTGGTTTTT CCTGTTTCCT 180
GCTCTGTAGC TGACATCAGG GGAGCAACGT GAACACAGGA AAATGGAAAT CAACATTTGA 240
AACTTTTAAA TGGAAGCTTT ATTGGGGTTC CACATATGGA AAACTGCAAA TAGCAGAAGT 300
ATGTGACTCA ATAAATTATT CTGGAGTGAC CACATCCTCT AACTGCCTCC CAGGACAAGA 360
CGGAGAATGT GAACAATGCT CCTGAAGGCC CCTTTCCCTC AAAGAATCAC TGCAATTGAA 420
GGAAAAATGC TCCATGTCCC CTCTGCCAGT TGGTGTTTAT CAAAGGACAA CGGAGGAAGA 480
GAGACAAAGT GCCTGGATGT GTGTGTTAAT CAAGAGTTGT CAGGACCCTG CCTCTAAAAG 540
AAAGCGCTAA AATGATGCTT TTGACAAGAC TTTTCTCAAA GTGGATGCAG TCTAAGGGTT 600
GGAAAACAAG GCCCAATCAG GCTAGGTCTG ACTTGTCGCC TGCTTTTGTA AATAAAGTTT 660
TATTGGCTCA CAGA 674
Seq ID NO: 89 DNA Sequence
Nucleic Acid Accession H : Eos sequence
1 11 21 31 41 51
I I I I I I
AGTGTGAAGG GAAGGCTAAG GACGCATCGG TGCTGGAGAG TTGAGAATAT GCCTTCCCCT 60
CCACCCCCAA CCCAGTCACC TTATTTGAAA AAAAATTAAA AAACACCTTT TATTTAAAAA 120
CCTAACCCTG GAAGTTTGCT CGCTGACATC AGGGGAGCAA CGTGAACACA GGAAAATGGA 180
AATCAACATT TGAAACTTTT AAATGGAAGC TTTATTGGGG TTCCACATAT GGAAAACTGC 240
AAATAGCAGA AGTATGTGAC TCAATAAATT ATTCTGGAGT GACCACATCC TCTAACTGCC 300
TCCCAGGACA AGACGGAGAA TGTGAACAAT GCTCCTGAAG GCCCCTTTCC CTCAAAGAAT 360
CACTGCAATT GAAGGAAAAA TGCTCCATGT CCCCTCTGCC AGTTGGTGTT TATCAAAGGA 420
CAACGGAGGA AGAGAGACAA AGTGCCTGGA TGTGTGTGTT AATCAAGAGT TGTCAGGACC 480
CTGCCTCTAA AAGAAAGCGC TAAAATGATG CTTTTGACAA GACTTTTCTC AAAGTGGATG 540
CAGTCTAAGG GTTGGAAAAC AAGGCCCAAT CAGGCTAGGT CTGACTTGTC GCCTGCTTTT 600
GTAAATAAAG TTTTATTGGC TCACAGA 627
Seq ID NO: 90 DNA Sequence
Nucleic Acid Accession tt: AB058765 2
Coding sequence- 400. 3492
1 11 21 31 41 51
I I I I I I
GGCGCGCCAG GTAAGGCAGG CGGACGCGCG GACCCCTCGG CGCAGTGCGG CCCCGAAGGC 60 GGTAGGGCGA GAAAGAGCTG GGACCCCCCC GCAACTTCGG GATCGGCTGG GTGAGGCTGG 120 GCAGGCCTGA TGCTCAGGGG TTCGTGCCGG GAAGTTCAGG TCCTCGGACA ACCTCTCTCC 180
AGCTCTCCGC CGCCGGTACC CACGGCCCAG TCTCCACCTG GGGAAACCCC CTTGGCGTGG 240
CTTGTTTCGT TACAAGTTAT CCTGGTAGAG TGGGCATGAA GGCCTCGGAG GCAACTGTGC 300 CTGCAGGTGT CCATCACCTT CAAGGACTTG GCCGTGCGGT TCTCGGAGGA GGAGTGGCGG 360
CTCCTGGAGG AGGGGCAGAG GGAGTTCTAC CGAGACGTGA TGCGGGAGAA CTACGAGACG 420 CTGGTCTCTG TGGGGACAGC TGAGCTGCTC CCCCTCTCTG CTTTCCTGTC ACCCTCAGAG 480 CCTGGAAGAG CTGTTGGGGG AGGGAGCCAC GCTGATGAGG GGCAGGAGCC TGCTGGTTGT 540 GGAGATCCCC AGGGGGGACA GCCCCGGCAC AGCCTGCACC TCACAGCCCT GGTGCAGCTG 600 GTGAAGGAGA TCCCAGAGTT CTTGTTTGGA GAAGTCAAGG GCGCTATGGA CAGCCCCGAG 660 AGCGAGAGCC GGGGAGCCAG CCTGGATGGA GAGAGAGCGA GCCCCGAGGC AGCTGCGGCA 720
AGAGAGCCCT GCCCTCTCCG AGGCCTGCTC AGCTGCCTTC CAGACGGCCC TACCAGCCAG 780
CCCCACCTGG CCACCACGCC CACCGACAGC TCGTGTTCCA GTGGCCCAAC TGGTGACGGG 840
GTCCAGGGAA GTCCTCTCCC CATCAAAACT GCCGACAAAC CGTGGCCTAC AAGGAAGGAA 900 GGCCCAGGAG CCCTGGGCGG GGAGCCCAGC CCTCCCACCC ATAGCCCCAG CAGGAGGAAG 960
AGCCACAGAG GACAGGAGAG AGGGACCTCA GAGGCCGGAA TTTCTCCTGG GAACAGCCCC 1020
TTGCAAGGCC TCATCAACTG TCTGAAGGAA ATCCTTGTGC CTGGGCCCCG GCACCCCGAG 1080
ACATCCCCAA GCTTCTTGCC ACCTCTCCCT AGCCTGGGCA CGTCCAGGCT AACCAGAGCA 1140
GACCTGGGGC CTGGGAGCCC GCCCTGGGCA GTGAAGACCG AGGCGGTTTC AGGGGATTGT 1200 CCCCTCCAGG GTCTGCTACA CTGTCTGAAG GAGCTCCCCG AGGCCCAGGA CAGGCATCCC 1260
AGTCCCTCAG GAGTGGGGAA CCGACGGCTA CAGGAGAATC CAGGAGCCTG GAAAAGGGGT 1320
TCTGGAGGGC CTGGATACCT CCTGACCCCT CCTCCCCATC CTGATCTTGG AGCTGGCGGT 1380
CTGCTCTCTG TGAAGATGGA GAACAGCTGG GTCCAGAGCC CCCCAGGACC TGCATCCTGT 1440
CAGCCTGGCA GGCAGCCCCT CAGTCCCTCA GCCACTGGAG ACACCAGAGG GGTCCCCCAA 1500 CCCAGCTGGG GCCCTGAGGC TCAAGCTGCC AGTGCCTCAA GCTCACCGCT GGAAGCCCTG 1560
GAAGCCTGTC TGAAGGGCAT TCCCCCAAAT GGGTCGTCAC CTTCCCAGCT GCCACCCACT 1620
TCTTGTTCCC AGAACCCCCA GCCAGGAGAC TCTAGGTCTC AGAAGCCTGA ACTGCAACCC 1680
CACAGATCAC ACAGTGAAGA AGCGACCAGA GAGCCTGTTC TGCCTCTGGG TCTGCAGAGC 1740
TGTGTGAGAG ATGGCCCCAG CAGGCCCCTG GCCCCCCGAG GAACCCCCAC CAGCTTCTCC 1800 TCATCCAGCA GCACCGACTG GGACCTGGAT TTTGGGAGTC CTGTGGGGAA CCAGGGGCAG 1860
CATCCTGGAA AAGGAAGCCC ACCAGGAAGC TCCCCACTGC AGGGTCTGGA GAATTGTCTC 1920
AAGGAGATAC CTGTGCCTGT GCTGCGGCCT GCCTGGCCCT GCTCCTCAGC AGCAGACAGG 1980
GGACCGAGGA GAGCAGAGCC CAGGAACTGG ACAGCAGACA AGGAAGGACT GAGGGCTGAG 2040
GCCTGCGAGT CAGCCCGTCT CGGGCAGGGT AGGGGAGAAG CGCCCACCCG GAGCCTCCAT 2100 CTGGTCAGCC CACAGGTGTT CACCTCCAGC TGCGTCCCCG CCTGCCACCA GCGGGGGTTC 2160
AAAGACCCTG GGGCCACCAG GCCAGGAGTG TGGAGGTGGC TCCCAGAGGG GTCTGCCCCC 2220
AAGCCCTCCC CGCTGCACTG CCTGGAGAGC GCCCTGAGGG GGATCTTGCC TGTAAGGCCC 2280
TTGCGCTTCG CCTGCGTGGG AGGCCCCAGC CCCAGCCCCA GCCCCGGCTC CAGCTCGAGC 2340
TTCAGCGGCT CTGAAGGAGA AGACCCGAGG CCAGAGCCTG AGCTCTGGAA GCCGCTCCCC 2400 CAGGAGAGGG ACCGCCTTCC CAGCTGTAAG CCTCCTGTCC CTCTGTCCCC ATGTCCTGGT 2460
GGGACCCCTG CTGGCAGCAG TGGCGGCAGC CCTGGTGAAG ACCCCAGGAG AACAGAGCCC 2520
AGGTACTGCA GCGGCCTCGG TGCAGGTACA GCTCAGGATC CCTGCCCGGT TTCTCAGCTG 2580
GAGAAAAGGC CCAGGGTTAG TGAAGCATCC AGAGGCCTGG AGCTTGGACA TGGAAGACCC 2640
AGAGTTGCAG CCAAGACCCA TGAGAGGCTG CTCCCCCAGG GCCCGCCTGA GCTGCCCAGT 2700 GAGTCTCCCC CTCCGGAGCT GCCCCCTCCG GAAGCTGCGC CTCCTGTGTT GCCAGCCTCC 2760
TCCCTGCAGC CGCCATGCCA CTGTGGGAAG CCCCTGCAGC AGGAGCTGCA CAGCCTCGGT 2820
GCTGCCCTTG CGGAGAAGCT GGATCGGCTC GCCACAGCGC TGGCAGGCCT GGCTCAGGAA 2880
GTGGCCACCA TGAGGACCCA GGTGAATCGG CTGGGGAGGC GCCCCCAAGG CCCTGGGCCA 2940
ATGGGCCAAG CTTCCTGGAT GTGGACCCTC CCACGGGGAC CTCGCTGGGC TCATGGCCCT 3000 GGTCACAGAC ATCTGCCCTA CTGGAGGCAG AAGGGACCCA CGAGGCCTAA ACCAAAGATC 3060
CTGCGTGGCC AGGGAGAGAG CTGCAGGGCT GGTGACCTGC AAGGACTCTC CAGAGGGACC 3120
GCTCGCCGGG CACGTCCGCT GCCTCCAGAC GCTCCCCCGG CAGAACCTCC TGGGCTCCAC 3180
TGCAGCTCTT CCCAGCAGCT GCTGTCCTCT ACACCCAGCT GCCATGCTGC GCCGCCTGCA 3240
CACCCCCTCC TCGCACATAC CGGGGGCCAC CAGAGCCCCC TTCCCCCTTT AGTGCCTGCT 3300 GCCTTACCCC TGCAGGGAGC CTCTCCTCCT GCAGCCAGTG CAGATGCAGA CGTGCCGACC 3360
TCAGGAGTGG CACCAGACGG GATCCCAGAG CGGCCCAAGG AGCCGAGCAG CCTGCTGGGA 3420
GGAGTGCAGA GGGCCCTCCA GGAAGAACTG TGGGGTGGGG AGCACAGGGA CCCGAGATGG 3480
GGGGCGCATT GATGGCATTC CTCTTCTCCA CATCTGCTCG TTCTTGCCGA GGGTGCAGTG 3540
GTGGCGTGGA AGCCCTGTCA CCCCACCCCA GGCCACCCTC TCCCAGAGGA CGCCATCTCC 3600 CTTACTGTTG CTGGGAGCCT CGCCCTTTGT CCCAACTGGG TAGAGCCCCC AGGTGCTGTT 3660
TGCTCAGGAG GCTGCTGTGG GGGTGCCTTC CTCAGCCTCT GGCCCTCTTG GCTCAGATTC 3720
AATCAAATGT TGCTTCCCTC TCCTGTCTTT CCCACTGGAG CCGCCCAAGC TTGTAGGTGG 3780
GTGGTGTGCA TAGGCCACGT GTGCCCCACA TATGCAGGGG GTGCCCCACA CAGCTAGAGC 3840
GGCCAGGAGA GCGCCTCCTA ACCACCAGCC GTTCCTGATC TCAGGAGCCT TGAAGGGCTG 3900 GGCTCTTGCC TTCCTGGAGT AAATATTGGC ACAGATTTCA TTTGAGAGAA CTCAGCCCCC 3960
TGGTCTAAGC TGGACTTACC TCTGTGGATT CTGAAATTAA AGAAGTGAGT TGCTAAGG 4018
Seq ID NO 91 DNA Sequence Nucleic Acid Accession # AL831935 1 Coding sequence 1854
1 11 21 31 41 51
I I I I I I
AGCCTGCTGG TTGTGGAGAT CCCCAGGGGG GACAGCCCCG GCACAGCCTG CACCTCACAG 60
CCCTGGTGCA GCTGGTGAAG GAGATCCCAG AGTTCTTGTT TGGAGAAGTC AAGGGCGCTA 120 TGGACAGCCC CGAGAGCGAG AGCCGGGGAG CCAGCCTGGA TGGAGAGAGA GCGAGCCCCG 180
AGGCTGCGGC AAGAGAGCCC TGCCCTCTCC GAGGCCTGCT CAGCTGCCTT CCAGACGGCC 240 CTACCAGCCA GCCCCACCTG GCCACCACGC CCACCGACAG CTCGTGTTCC AGTGGCCCAA 300 CTGGTGACGG GGTCCAGGGA AGTCCTCTCC CCATCAAAAC TGCCGACAAA CCGTGGCCTA 360 CAAGGAAGGA AGGCCCAGGA GCCCTGGGCG GGGAGCCCAG CCCTCCCACC CATAGCCCCA 420 GCAGGAGGAA GAGCCACAGA GGACAGGAGA GAGGGACCTC AGAGGCCCCA ATTTCTCCTG 480 GGAACAGCCC CTTGCAAGGC CTCATCAACT GTCTGAAGGA AATCCTTGTG CCTGGGCCCC 5 0 GGCACCCCGA GACATCCCCA AGCTTCTTGC CACCTCTCCC TAGCCTGGGC ACGTCCAGGC 600 TAACCAGAGC AGACCTGGGG CCTGGGAGCC CGCCCTGGGC AGTGAAGACC GAGGCGGTTT 660 CAGGGGATTG TCCCCTCCAG GGTCTGCTAC ACTGTCTGAA GGAGCTCCCC GAGGCCCACC 720 ACAGGCATCC CAGTCCCTCA GGAGTGGGGA ACCGACGGCT ACAGGAGAAT CCAGGAGCCT 780 GGAAAAGGGG TTCTGGAGGG CCTGGATACC TCCTGACCCC TCCTCCCCAT CCTGATCTTG 840 GAGCTGGCGG TCTGCTCTCT GTGAAGATGG AGAACAGCTG GGTCCAGAGC CCCCCAGGAC 900 CTGCATCCTG TCAGCCTGGC AGGCAGCCCC TCAGTCCCTC AGCCACTGGA GACACCAGAG 960 GGGTCCCCCA ACCCAGCTGG GGCCCTGAGG CTCAAGCTGC CAGTGCCTCA AGCTCACCGC 1020 TGGAAGCCCT GGAAGCCTGT CTGAAGGGCA TTCCCCCAAA TGGGTCGTCA CCTTCCCAGC 1080 TGCCACCCAC TTCTTGTTCC CAGAACCCCC AGCCAGGAGA CTCTAGGTCT CAGAAGCCTG 1140 AACTGCAACC CCACAGATCA CACAGTGAAG AAGCGACCAG AGAGCCTGTT CTGCCTCTGG 1200 GTCTGCAGAG CTGTGTGAGA GATGGCCCCA GCAGGCCCCT GGCCCCCCGA GGAACCCCCA 1260 CCAGCTTCTC CTCATCCAGC AGCACCGACT GGGACCTGGA TTTTGGGAGT CCTGTGGGGA 1320 ACCAGGGGCA GCATCCTGGA AAAGGAAGCC CACCAGGAAG CTCCCCACTG CAGGGTCTGG 1380
AGAATTGTCT CAAGGAGATA CCTGTGCCTG TGCTGCGGCC TGCCTGGCCC TGCTCCTCAG 1440
CAGCAGACAG GGGACCGAGG AGAGCAGAGC CCAGGAACTG GACAGCAGAC AAGGAAGGGT 1500
CTGCCCCCAA GCCCTCCCCG CTGCACTGCC TGGAGAGCGC CCTGAGGGGG ATCTTGCCTG 1560
TAAGGCCCTT GCGCTTCGCC TGCGTGGGAG GCCCCAGCCC CAGCCCCAGC CCCGGCTCCA 1620
GCTCGAGCTT CAGCGGCTCT GAAGGAGAAG ACCCGAGGCC AGAGCCTGAT CTCTGGAAGC 1680
CGCTCCCCCA GGAGAGGGAC CGCCTTCCCA GCTGTAAGCC TCCTGTCCCT CTGTCCCCAT 1740
GTCCTGGTGG GACCCCTGCT GGCAGCAGTG GCGGCAGCCC TGGTGAAGAC CCCAGGAGAA 1800
CAGAGCCCAG GTACTGCAGC GGCCTCGGTG CAGGTGAGCC TGGGGTCTCC TGAGGGGGCG 1860 0 CCCATGCGTT CCCCAGAGGA CCAGGAGTCC AGACTGGATC CTTTGAGTCC TGCCTGTCGC 1920
TTTGCCTGGC TCTTGCCAGG GAGTCCTGCA CATTGGCCGT GCTTTAGTTC CCTGTAAGGT 1980
ACAGCTCAGG ATCCCTGCCC GGTTTCTCAG CTGGAGAAAA GGCCCAGGGT TAGTGAAGCA 2040
TCCAGAGGCC TGGAGCTTGC ACATGGAAGA CCCAGAGTTG CAGCCAAGAC CCATGAGAGG 2100
CTGCTCCCCC AGGGCCCGCC TGAGCTGCCC AGTGAGTCTC CCCCTCCGGA GCTGCCCCCT 2160 5 CCGGAAGCTG CGCCTCCTGT GTTGCCAGCC TCCTCCCTGC AGCCGCCATG CCACTGTGGG 2220
AAGCCCCTGC AGCAGGAGCT GCACAGCCTC GGTGCTGCCC TTGCGGAGAA GCTGGATCGG 2280
CTCGCCACAG CGCTGGCAGG CCTGGCTCAG GAAGTGGCCA CCATGAGGAC CCAGGTGAAT 2340
CGGCTGGGGA GGCGCCCCCA AGGCCCTGGG CCAATGGGCC AAGCTTCCTG GATGTGGACC 2400
CTCCCACGGG GACCTCGCTG GGCTCATGGC CCTGGTCACA GACATCTGCC CTACTGGAGG 2460 0 CAGAAGGGAC CCACGAGGCC TAAACCAAAG ATCCTGCGTG GCCAGGGAGA GAGCTGCAGG 2520
GCTGGTGACC TGCAAGGACT CTCCAGAGGG ACCGCTCGCC GGGCACGTCC GCTGCCTCCA 2580
GACGCTCCCC CGGCAGAACC TCCTGGGCTC CACTGCAGCT CTTCCCAGCA GCTGCTGTCC 2640
TCTACACCCA GCTGCCATGC TGCGCCGCCT GCACACCCCC TCCTCGCACA TACCGGGGGC 2700
CACCAGAGCC CCCTTCCCCC TTTAGTGCCT GCTGCCTTAC CCCTGCAGGG AGCCTCTCCT 2760 5 CCTGCAGCCA GTGCAGATGC AGACGTGCCG ACCTCAGGAG TGGCACCAGA CGGGATCCCA 2820
GAGCGGCCCA AGGAGCCGAG CAGCCTGCTG GGAGGAGTGC AGAGGGCCCT CCAGGAAGAA 2880
CTGTGGGGTG GGGAGCACAG GGACCCGAGA TGGGGGGCGC ATTGATGGCA TTCCTCTTCT 2940
CCACATCTGC TCGTTCTTGC CGAGGGTGCA GTGGTGGCGT GGAAGCCCTG TCACCCCACC 3000
CCAGGCCACC CTCTCCCAGA GGACGCCATC TCCCTTACTG TTGCTGGGAG CCTCGCCCTT 3060 0 TGTCCCAACT GGGTAGAGCC CCCAGGTGCT GTTTGCTCAG GAGGCTGCTG TGGGGGTGCT 3120
TTCCTCAGCC TCTGGCCCTC TTGGCTCAGA TTCAATCAAA TGTTGCTTCC CTCTCCTGTC 3180
TTTCCCACTG GAGCCGCCCA AGCTTGTAGG TGGGTGGTGT GCATAGGCCA CGTGTGCCCC 3240
ACATATGCAG GGGGTGCCCC ACACAGCTAG AGCGGCCAGG AGAGCGCCTC CTAACCACCA 3 00
GCCGTTCCTG ATCTCAGGAG CCTTGAAGGG CTGGGCTCTT GCCTTCCTGG AGTAAATATT 3360 5 GGCACAGATT TCATTTGAGA GAACTCAGCC CCCTGGTCTA AGCTGGACTT ACCTCTGTGG 3420
ATTCTGAAAT TAAAGAAGTG AGTTGCCAAA AAAAAAAAAA AAAA 3464
Seq ID NO: 92 DNA Sequence
Nucleic Acid Accession H : BC029071.1 0 Coding sequence: ..771
1 11 21 31 41 51
I I I I I I
CGGACGCGTG GGCGGACGCG TGGGCGGCTG AGGAGTGGGG TGATGATGCC ACTGGCAGAA 60
GCAGGCGCCC TGGCCCAAGG AGGAGGCCCT TCAGCAACGG AGTGGGCCTG CATTCTGCGG 120 5 AGGAAGACCC CCAGGCACAA GCAGCCCACC TTACTGATGG TCAGAGCATC CAGAAGAAGT 180
GGCAAGACTT CAGCTGTCCT CAAAGCAGGA AGACAGAGTG TTTCTGGCAG AAAGAACAGC 240
ACAAGCAAAG ATCTGGTAAC CCTAGGTGCC TCCAGTTTGA GGGAGGAGAG AGGACACCCC 300
CTCCACCCCA GACATAGGAA AGCAGTCCAC CTGCGCACCA GGGGCAGGAC ACGTGGCTGG 360
GTGCAGACGC TGGCCCGGAT GTCGCGGAGG ACTCGCGGGC CGGTAGAGCG CGCGGCGGCG 420 0 GCGGCGGCGG CGGCGGCGGG AGGAGACGCA GGTCACGCCC CCTTCCCACC ACCTCCCGCC 480
GCCGACGGGG CGCGCGCGCC GAGGAGCCCG GGACAGGTGA CTCCTAGAGG ACTGCGTCTG 540
CGCCTCCCCC GGCGGGAGTC CCTTCTTCGC GGCCTCTGCC GCCCCCTGCG TCCCCTCCTG 600
GGCTTCCGAG AGTCTGACTC AGCCAAGCCG GCATCGCTTC GCCTCCTACA ACACACCCCG 660
AGCGCGAGAA GAAATTACAG GATTGCAGGG GCACGGCTAA TGCGCTCTAA TTACCCACCG 720 5 CCGCTGTCAT CCGCGGCGCT CCGCGGCGCT GGGCCAACGC GCCGTAATTA AGACGCCGCT 780
CCCCGCTCCC GGAACCCTCC CTTCGCCACC CTCCACCCAC CCACCTCGCG GTCCCCAGGA 840
CCACTGGCTG CCAACTCCTG CCGCCCTCTG GGACTGCCCC TCAGTCCCAG GAGAGCTATG 900
AGGCCTCACT GGGGGCAGAA CTTGGGGAGA CCGAAGCCGG CCCTTCCACT CCCCTAAACC 960
TACAGTCCTG GAAGGTCTCT GCTGGAAGAG ACTGGGAGAG TGGGGAGGGG CCAGGGACCT 1020 0 ATTTCGTTGA CAGAAACAGT GAGGTCTATT GGAAAGTTAG CCTTCAGTGG GAGGAGTGGC 1080
AAAGGCACGC AGGGCAGCAG TACCCCCGTT TGGCACTTGA GGCACGGAGA AGGGAAGGGA 1140
AGTCCGCCCA GCCAGAACTC CCAGACCCGC TCGTTTAACA GTGGCTTTAT GAGCAGCACG 1200
ACGGACTCCC TCCCCTGGCG GGGAAATTAC CTTCCTGCGA AGAAAGGTGA CATCCCCGCC 1260
ACAGACACGG AGGCCCCGCC TGCTGGCCAG CTGTGGCCGC CATAGGGGAG CTGGTGAGGA 1320 5 GTGAGGTGGC TCTGGCCTCC CATGTCAGGT AGGGTGAGAG AGGCCCTGAA GATAGAAGCC 1380
AGGCCCGAAG GCCAGAATTA AAGGGGTAGC TTGGCCATCA GCTCCTTCCC CCAAAACCAG 1440
GCTCAGAGCT CTCCTCTATC AGCAATTCTT TCCTGAGGTC CAGGGTGTTG CAAACTCATG 1500
GCCTTGGGCC ACGTTTTACC TTCAGTGAGG TTTTGTTTGG CTTGCAATGA GTACATCCGT 1560
TTTAGGTTGA ATGTGAGAGT CTGCAGACAA TGTGGGTTCT CCGACTGCCC TCCCAGTGAA 1620 0 GGTGGACCTC TGATTTAGAC CGGCCCGCTG GGCCCGTGCC TACATCCTTT TCCTCAGCGT 1680
CAGGATCTTA GTCCCCATGA TTGCTGCCCC TTTGTGGTCT GCATGTTTCT TGGTAAGGGT 1740
GCCCAGTCAA GTGTCTCTGG GAGCCCCCTC TTCTCTGTCA TCGTCAGGCT CCCCACTTGC 1800
AGTGGCCGTG GTGGCTGCAC ATGCTCCCGG ATACCCCTCC AGCACTCCCT TTTGTCATCT 1860
TGAGTTTCAG TCCGTGACTT GGGTGGCACC CTATCTTCTC CATCAGGGAT GGTAGCTATT 1920
75 TTTCTGCCAT GAGACTAGAG GTTGCTTGAG AACAGGAAAT TGGATCTCTC CCTTCAGGCT 1980
GGGATTTCAC TAAGGGCTGG AGAAGGGGGG AATATGGGAG GATTATCTCC TATCACAGGG 2040
AGCGCTCTGA GGGCAAGGCT GTGTCTCCGA TTCAGACTGA CGGTTCCCTG AGGATGGGGC 2100
TGTTTCTCCC CTCCGACTGG GGCTCCCTGA GGATGGGGCT GTTTCTCCCC TCCGACTGGG 2160
_ _ GCTCCCTGAG GACAGGGCTG TGTCTCCCCT CAGCCTGGGG CTCCCTGAGT CAGGGCTGTG 2220
80 TCTCCCCTCA GACTGGGGCT CCCTGAGGAC GGGGCTGTGT CTGCCTCAGA CTGGGAATCC 2280
CTGAAGATGG GGCCGTGTCT CCCTCAAAGT GGGGCTCCCT CAGGACAGCG TTGTGTCTCC 2340
CCTCAGACTG CGGCTCCCTG AGGACGGGGC TGTGTCTCCC TCAGACTGGG GCTCCCTGAA 2400
GAAAGGGCTG CTTCTCCCTC AGACTGGAGC TCCCTGAAGA TGGGGCTGTG TCCCCCTCAG 2460
ACTGGGGCTG CCTGAGGACG AGGCTGCATC TCCCCTCAGA CTGGAGCTCC CTGAGGGCAG 2520 GGCTGTCTCC CCCCTTCAGA CTGGGGCCTC CCCCAAAGGA CAGGGACTGT GTCTCCCCTG 2580
GGACTAGGTT CTTTGTGTCT TCTGCATCAG ACAGATTCCC ATGAGGACAG GGCTGTCTCC 2640
CCCTCCATCT GGAGCTCCCT GAAGGCAATG GCCTCTCCCC TCAAATGGGA CATTTGCACC 2700
CCACCCCACC CTCTGGCTCC CCATGGCGCC CAGGCATTCC TCCCAGGACA CCATTTGTCA 2760
CGCTTTGATG AATGAAACTT ACTAAAAAAA AAAAAAAAAA 2800
Seq ID NO: 93 DNA Sequence
Nucleic Acid Accession tt -- NM_002104.l
Coding sequence: 41..835
1 11 21 31 41 51
I I I I I I
AACACATTTC ATCTGGGCTT CTTAAATC A AATCTTTAAA ATGACTAAGT TTTCTTCCTT 60
TTCTCTGTTT TTCCTAATAG TTGGGGCTTA TATGACTCAT GTGTGTTTCA ATATGGAAAT 120
TATTGGAGGG AAAGAAGTGT CACCTCATTC CAGGCCATTT ATGGCCTCCA TCCAGTATGG 180
CGGACATCAC GTTTGTGGAG GTGTTCTGAT TGATCCACAG TGGGTGCTGA CAGCAGCCCA 240
CTGCCAATAT CGGTTTACCA AAGGCCAGTC TCCCACTGTG GTTTTAGGCG CACACTCTCT 300
CTCAAAGAAT GAGGCCTCCA AACAAACACT GGAGATCAAA AAATTTATAC CATTCTCAAG 360
AGTTACATCA GATCCTCAAT CAAATGATAT CATGCTGGTT AAGCTTCAAA CAGCCGCAAA 420
ACTCAATAAA CATGTCAAGA TGCTCCACAT AAGATCCAAA ACCTCTCTTA GATCTGGAAC 480
CAAATGCAAG GTTACTGGCT GGGGAGCCAC CGATCCAGAT TCATTAAGAC CTTCTGACAC 540
CCTGCGAGAA GTCACTGTTA CTGTCCTAAG TCGAAAACTT TGCAACAGCC AAAGTTACTA 600
CAACGGCGAC CCTTTTATCA CCAAAGACAT GGTCTGTGCA GGAGATGCCA AAGGCCAGAA 660
GGATTCCTGT AAGGGTGACT CAGGGGGCCC CTTGATCTGT AAAGGTGTCT TCCACGCTAT 720
AGTCTCTGGA GGTCATGAAT GTGGTGTTGC CACAAAGCCT GGAATCTACA CCCTGTTAAC 780
CAAGAAATAC CAGACTTGGA TCAAAAGCAA CCTTGTCCCG CCTCATACAA ATTAAGTTAC 840
AAATAATTTT ATTGGATGCA CTTGCTTCTT TTTTCCTAAT ATGCTCGCAG GTTAGAGTTG 900
GGTGTAAGTA AAGCAGAGCA CATATGGGGT CCATTTTTGC ACTTGTAAGT CATTTTATTA 960
AGGAATCAAG TTCTTTTTCA CTTGTATCAC TGATGTATTT CTACCATGCT GGTTTTATTC 1020
TAAATAAAAT TTAGAAGACT 1040
Seq ID NO: 94 DNA Sequence
Nucleic Acid Accession It : NM_052947.1
Coding sequence: 199..4794
1 11 21 31 41 51
I I I I I I
GAATCTGCTG AGCCCCCACT AACCCAGAGT GATAAAAGAG AGACTTCTCA CACCACAGCA 60
GCAGCGACTG GTCGGAGTTC CCATGCTGAT GCAAGAGAAT GTGCTATTTC AACCCAGGCA 120
GAGCAAGAAG CAAAAACCCT TCAAACTTCA ACAGACTCAG TCTCCAAAGA AGGCAACACA 180
AATTGCAAGG GAGAAGGCAT GCAAGTTAAT ACTCTATTTG AAACAAGCCA GGTTCCAGAC 240
TGGAGTGATC CTCCTCAGGT ACAAGTTCAG GAAACAGTCA GAGAGACAAT CTCTTGCAGC 300
CAGATGCCAG CTTTCTCAGA GCCTGCTGGG GAGGAGTCCC CATTCACTGG GACCACAACA 360
ATTTCCTTCT CAAACTTAGG AGGGGTCCAC AAGGAAAATG CATCATTAGC TCAACACTCG 420
GAGGTCAAAC CCTGTACCTG TGGTCCACAG CAGGAAGAAA AACAAGACAG AGATGGCAAC 480
ATACCTGACA ATTTCAGGGA AGACCTAAAA TATGAGCAGA GCATCTCAGA AGCCAATGAT 540
GAGACTATGT CCCCAGGTGT GTTCTCAAGG CATCTCCCCA AGGATGCTCG TGCTGACTTC 600
AGGGAGCCTG TGGCTGTCTC TGTTGCTTCC CCTGAACCCA CAGATACTGC CCTCACCCTG 660
GAAAATGTGT GTGATGAGCC AAGGGACAGA GAAGCAGTGT GTGCAATGGA GTGTTTTGAG 720
GCTAGTGACC AAGGAACATG TTTTGATACC ATAGATTCTC TTGTTGGGAC ACCAGTTGAT 780
AACTATTCGC CTCAAGAAAT TTGCTCTGTA GATACGGAAC TGGCAGAAGG TCAAAACAAA 840
GTATCTGATT TATGTTCTTC TAATGACAAG ACACTGGAAG TCTTTTTTCA GACACAAGTG 900
TCTGAGACTT CAGTGTCTAC GTGCAAAAGC AGCAAGGACG GCAACTCAGT CATGTCCCCT 960
CTTTTTATCA GTACTTTCAC CTTGAACATT TCACACACAG CTAGTGAAGG TGCCACAGGA 1020
GAAAATCTAG CCAAGGTGGA GAAATCCACC TACCCACTGG CCTCCACAGT ACATGCTGGC 1080
CAGGAGCAGC CAAGCCCCAG CAACTCAGGA GGGCTTGATG AAACACAGCT CCTTTCTTCT 1140
GAGAACAATC CTTTAGTGCA ATTTAAAGAA GGAGGTGACA AGAGCCCCAG TCCTAGTGCC 1200
GCAGACACCA CAGCCACACC AGCCAGTTAT AGTTCAATTG TGAGTTTTCC TTGGGAGAAG 1260
CCAACAACAT TAACTGCTAA TAATGAGTGC TTTCAAGCGA CCAGAGAGAC TGTTACCATT 1320
GCCACCGAAG TCCACCCAGC CAAATACCTT GCTGTGTCAA TTCCTGAGGA CAAGCATGCA 1380
CCTGGCACTG AGGAGAGGTT CCCTCGTGCA TCCCATGAAA AGGTTTCCCA ATTTCCTTCC 1440
CAAGTGCAGG TGGATCATAT TTTAAGTGGT GCTACCATCA AATCTACAAA AGAGCTACTT 1500
TGCAGGGCAC CCAGTGTGCC AGGAGTCCCA CACCATGTCC TGCAGCTCCC AGAGGGAGAG 1560
GGTTTCTGCA GTAATTCCCC TCTTCAGGTT GATAACCTGT CTGGAGATAA GAGCCAGACT 1620
GTGGACAGAG CAGACTTTAG GAGCTATGAA GAGAATTTCC AAGAAAGAGG AAGTGAAACA 1680
AAGCAGGGGG TCCAGCAGCA GAGCCTGTCC CAGCAGGGTT CTCTTTCTGC ACCTGATTTC 1740
CAACAAAGTT TGCCTACGAC ATCTGCTGCA CAAGAGGAAA GAAACTTGGT GCCCACGGCC 1800
CCCTCACCAG CAAGCTCTAG GGAAGGAGCA GGGCAGCGCT CAGGTTGGGG GACGAGGGTC 1860
TCCGTGGTGG CTGAAACTGC TGGGGAAGAA GACAGTCAGG CTCTGAGCAA CGTTCCATCT 1920
CTCTCTGATA TCCTTTTGGA AGAGTCTAAA GAATATAGAC CTGGAAATTG GGAGGCAGGC 1980
AACAAGCTGA AGATTATAAC TCTAGAGGCT TCCGCTTCTG AAATCTGGCC ACCACGACAA 2040
CTGACAAATT CTGAGAGCAA GGCATCAGAC GGTGGTCTCA TAATTCCTGA CAAGGTCTGG 2100
GCTGTACCTG ATAGTCTAAA GGCAGATGCT GTTGTGCCTG AATTGGCCCC CTCTGAAATA 2160
GCAGCATTGG CTCACAGTCC AGAGGATGCT GAGTCAGCCC TTGCTGATAG CAGAGAAAGC 2220
CATAAAGGCG AAGAGCCCAC CATCAGTGTA CACTGGAGAA GTCTTTCTTC CCGGGGTTTC 2280 AGCCAACCGA GACTCCTGGA GTCATCCGTG GACCCTGTAG ATGAAAAGGA GTTATCTGTC 2340
ACAGATTCAC TGTCAGCGGC TTCTGAAACT GGAGGGAAGG AAAATGTTAA CAATGTGAGT 2400
CAAGACCAGG AGGAAAAACA ACTCAAGATG GATCACACTG CCTTCTTTAA AAAGTTTCTG 2460 ACCTGCCCTA AAATCCTAGA GTCCTCTGTA GATCCCATTG ATGAGATAAG TGTGATAGAG 2520 TACACCAGGG CTGGAAAACC AGAGCCCTCT GAAACCACAC CACAGGGCGC CAGAGAAGGA 2580 GGTCAATCAA ATGACGGAAA CATGGGCCAC GAAGCGGAAA TCCAGTCGGC CATTTTGCAA 2640 GTTCCATGTC TCCAGGGAAC CATTCTGAGT GAAAATAGAA TCAGCAGAAG CCAAGAAGGC 2700 AGTATGAAGC AGGAGGCAGA ACAAATTCAA CCTGAGGAGG CAAAAACTGC CATTTGGCAA 2760 GTCCTGCAAC CCAGCGAAGG CGGTGAAAGA ATTCCAAGTG GATGTAGCAT AGGCCAAATA 2820 CAAGAAAGCA GTGATGGGAG CTTAGGGGAG GCTGAGCAAA GCAAAAAGGA CAAAGCAGAA 2880 TTGATTTCCC CCACTTCACC TCTTTCTAGT TGTCTTCCAA TAATGACTCA CTCTTCTCTT 2940 GGGGTTGACA CGCACAACTC CACAGGCCAA ATTCATGACG TCCCTGAAAA TGACATAGTT 3000
GAGCCCAGAA AGCGTCAGTA TGTGTTTCCT GTTTCACAGA AAAGGGGAAC TATTGAGAAT 3060
GAGCGTGGGA AACCTTTGCC CTCTTCTCCT GATCTTACCA GGTTCCCTTG TACTTCATCT 3120
CCTGAAGGAA ATGTCACAGA CTTTTTGATA AGCCACAAAA TGGAGGAACC TAAAATAGAG 180 GTGCTTCAAA TTGGGGAAAC CAAACCCCCA AGCTCATCTA GCTCCTCAGC GAAGACCTTG 3240
GCATTTATTT CAGGAGAACG TGAGTTAGAG AAAGCCCCTA AGTTACTGCA GGATCCATGT 3300
CAAAAGGGCA CCCTGGGCTG TGCGAAAAAG TCCAGGGAGA GAGAGAAGTC CCTGGAAGCC 3360
CGAGCAGGCA AATCGCCAGG GACCCTCACA GCAGTGACGG GGTCAGAGGA GGTCAAGAGG 3420
AAGCCAGAAG CCCCAGGCAG TGGACATTTA GCTGAGGGAG TAAAGAAGAA AATTTTGTCC 480 AGGGTGGCAG CACTGAGGCT GAAACTGGAA GAAAAGGAAA ATATCAGAAA GAACTCAGCC 3540
TTTCTTAAAA AGATGCCCAA ACTCGAAACA TCATTATCAC ACACAGAAGA GAAACAAGAC 3600
CCAAAAAAGC CATCTTGCAA AAGAGAAGGA AGAGCTCCAG TATTACTGAA AAAAATCCAA 3660
GCTGAGATGT TCCCTGAACA CTCTGGAAAT GTAAAATTAA GCTGCCAATT TGCAGAAATT 3720
CATGAAGATT CTACTATCTG CTGGACAAAA GATTCAAAGT CCATAGCCCA AGTGCAGAGA 3780 AGTGCAGGGG ACAACTCCAC TGTTTCCTTT GCCATCGTGC AAGCCAGTCC GAAGGACCAG 3840
GGACTCTATT ACTGCTGCAT CAAGAACAGC TACGGAAAAG TGACTGCTGA ATTTAACCTC 3900
ACAGCTGAAG TTCTCAAACA GCTGTCAAGT CGCCAGGATA CTAAAGGATG TGAAGAGATT 3960
GAATTCAGCC AACTCATCTT CAAAGAAGAC TTCCTCCATG ACAGCTACTT TGGGGGCCGC 4020
CTGCGTGGTC AGATCGCCAC GGAGGAGCTG CACTTTGGAG AAGGGGTTCA CCGCAAAGCC 4080 TTCCGCAGCA CAGTGATGCA CGGCCTCATG CCTGTCTTCA AACCTGGCCA TGCCTGTGTG 4140
CTTAAGGTGC ACAATGCCAT TGCCTATGGG ACCAGAAATA ATGATGAGCT CATCCAAAGG 4200
AACTACAAAC TCGCTGCCCA GGAATGCTAT GTTCAAAATA CTGCCAGGTA TTATGCCAAG 4260
ATCTACGCTG CTGAAGCACA GCCTCTGGAA GGCTTTGGAG AAGTACCTGA GATCATTCCT 4320
ATTTTTCTTA TCCATCGGCC TGAGAACAAT ATCCCGTATG CTACAGTGGA GGAGGAGCTG 4 80 ATTGGAGAAT TTGTGAAGTA TTCCATCAGG GATGGGAAAG AAATAAACTT CTTGAGAAGA 4440
GAATCAGAAG CTGGTCAGAA ATGTTGCACC TTCCAGCACT GGGTGTACCA GAAAACAAGT 4500
GGCTGCCTCC TGGTGACGGA CATGCAAGGT GTAGGAATGA AGCTAACTGA CGTTGGCATA 4560
GCAACGCTGG CTAAAGGGTA CAAGGGATTT AAAGGCAACT GTTCCATGAC CTTCATTGAT 4620
CAGTTTAAAG CACTACACCA GTGTAACAAG TATTGCAAAA TGCTGGGACT GAAATCCCTT 4680 CAAAACAACA ACCAGAAACA GAAGCAGCCG AGCATTGGGA AAAGCAAAGT TCAAACAAAC 4740
TCTATGACAG TAAAGAAGGC AGGGCCTGAG ACCCCAGGCG AAAAGAAAAC CTAACGTCCC 4800
TGGGTAACCT AATGGCCACT GGCTAGCAGC ACACAATCTC GCCAGGGAAA ATCTGAGGCC 4860
ACACAGGAGA GAATATACAG CCTGCAGAGA GTGCGTGGCA ATCCTTACCC CCAGCCGACT 4920
GTGCGCCAAG ATGCTTCTAA ACCCATCACC TGCTGTCTTC ACTCAAATGA TTTCAGAACA 4980 GGATTTGCGA CCAGGTTTAT GGGGAGATTG AATCAACGAT TGGTCTCAAA GACAGGCCAT 5040
TCTTTATATA CACGTTTAGC ATTTTTACCA ACCTCACATC ATGTGTATAT TTGTGTATTT 5100
GCACATGGTT GTGCTGTCGA GGACCTGGTG CTGAGAAGAG TCTGTTCACA GCCAAAATTC 5160
TTCCCACTGT CATTCCTAAC CTGGGATTTC TAGACACATC CTGCTGTGAT GTAAACAGAA 5220
ATCACGAATT CGCTCACTCC ATCAAGTTGT TCCACTCCTG TCTAATACGC TATTGTTGCC 5280 GGAGGTGGGT TCTGTGACGT GAAGCCATTT CCCATCATTC AACAGCCAGT TACAATTTTC 5340
TGTTTAATTA AATTCATATT TAAACAAAAA AAAAA 5375
Seq ID NO 95 DNA Sequence
Nucleic Acid Accession tt NM_134421 1
Coding sequence 527 1108
1 11 21 31 41 51
I I I I I I
AGCTTCTGCC AAGGGTGGGG GCCCACGCGG AGGCGATCCG CTCGTTCCTC CCAGGGCCAT 60
GGGGCGACGA GGAGAGCCCT GGCCTCCCCG CGACCCGCAC CGCGACCTGG GCCAGACGCG 120
CCACCTTCCC CGGTCGCGGT TTGCTTCTCT TTAAAATGAG GACAGCTCCT CCCTTGGGGG 180
CTGTGGTGAC AGGTGAAATG AGAACGCACT GAAGACAGCT CTTGGTCCAA AGCCCCGCAC 240
ACAGGGCATG GTCTAGTGGC CCAGTCAGGA CGCGGAAACA CTCCCTGGAG GTTCTGACCC 300
ACTCCCTCTC AGCCTCCGCC TGGTCTCTGG GTTGGCTGTT CCAGCTCCAA AGAGAAGGAG 360
GAACCTTTTC CTTCTGCAGC CCCTCCCCAC CAGCTCCATT CCTTAGCTGG GGTCAGACCT 420
GGGGTCCTCA CTGCAGCTGG CCTCTGGCAG CGTTCTCAGG CTAGCCCTCC CTGCTGAAAA 480
GAGAACCGTG TGGGACTCAC AGGTGTAGTC GCCGCCGCCA GCCGCCATGG GCAAACAGAA 540
CAGCAAGCTG CGGCCCGAGG TGCTGCACCA CCTGCGGGAG AACACGGAGT TCACCGACCA 600
CGAGCTGCAG GAGTGGTACA AGGGCTTCCT CAAGGACTGC CCCACCGGCC ACCTGACCGT 660
GGACGAGTTC AAGAAGATCT ACGCCAACTT CTTCCCCTAC GGCGACGCTT CCAAGTTCGC 720
CGAGCACGTC TTCCGCACCT TCGACACCAA CGGCGACGGC ACCATCGACT TCCGGGAGTT 780
CATCATTGCG CTGAGCGTGA CCTCGCGGGG CAAGCTGGAG CAGAAGCTCA AGTGGGCCTT 840
CAGCATGTAC GACCTGGACG GCAACGGCTA CATCAGCCGC AGCGAGATGC TGGAGATCGT 900
GCAGGCCATC TACAAGATGG TGTCGTCTGT GATGAAGATG CCGGAGGATG AGTCCACCCC 960
GGAGAAGCGC ACAGACAAGA TCTTCAGGCA GATGGACACC AACAATGACG GCAAACTGTC 1020
CTTGGAAGAA TTCATCAGAG GTGCCAAGAG CGACCCCTCC ATCGTCCGCC TGCTGCAGTG 1080
CGACCCCAGC AGTGCCAGTC AGTTCTGAGC GAGCGGCCCC TGGACAGTTG CAGAGAAACA 1140
CAGGCTTGTC GTGCCGTTTA AGCTTTGCTT GCAAGAGTGG ATGCCCCGCA ATCGTTCCTG 1200
CTCTCCCGGG CCCCGGGCCT GGGGCATGCG TTGCACCTGC CCGGCCCGGT GGCTGCGCCT 1260
CCCTCCTCCA CCTGACCAAC GCGACATTCC TCCCCTCACG CCTGGCCCGG TCCCTTCCAG 1320
GGCAACTCCC AGGGATGTGG TGACATGCAG GGTTCAAGTG TTCTTGGTTC CAGGCACCTC 1380
CCGGCTCACG GGGAGCTCAG AGGTCCATGC CGAGGAGACC AGGCAGGACC TCCCGAGGCT 1440
GCGCCCCGGC CGGCCCATGC GTTTTGTGAT CCCAAGTGAC TCTGTGGGAA GGGTGGGGAC 1500
GAGGCGTCGG GAGGGTATAC AGGGAGCCCC TCCCGTGCAT GGCTGCCCCC CCGTTCATTT 1560
TCTCCACCAC AGCCGCTTGC ACGTATAGAT ACTGTGGTCC CCTTTCTTTT AATATATAAA 1620
TTATGTATGG TGAAGTGGAG TGTATTGTGT AGGTCCCGTA TTTAATGCCT CTGACTGCCT 1680
TTGAAGCGCA GCCCTCTGTG GCCCGCAGCC CCCTGAGCCT GGCTGTTGTG TGGTATTTAT 1740
GCTCTCTTTG TCTGCCTGTT TCTAAGGAAA TGCATGTGTG CCCTGAGCCG TGATGATCCT 1800
CCCATCCGTG TTGTGAGCAC AGGCATTTGT GTCTGGTCTG TCCTCCCTGT TGATTGGTCT 1860
GGCATTTCCG GTATTAAAAT GATAAAATAA ATGGCATTTT CTGAAAAAAA AAAAAAAAAA 1920
Seq ID NO 96 DNA Sequence
Nucleic Acid Accession ft NM_002149 2
Coding sequence 375 956
1 11 21 31 41 51 I I I I I I
CGGCGGCGGC GGGCAGCGGA CGGGCGGACT GACGGGCGCC TCCACCTTGC TCCCTCCCTG 60
GCTGCCGGCT TCCTTTTGTC TTTCTGGGCG GCGATGAGCG CAGGGCCGGC GCAGCAGCTG 120
CGGGCGCACG GAGGCCCGCG CTGCTAGTCA CTCCTCCCGG CCTCGGCGCG CTTGTCCCGG 180
GCAGCGGCCC GGGCCCGCTG CAGCCGCCGC CGGCGCCGAA CTTGGGCTCG GGAAGCCGGC 240
GGACCGCGTC CTGCGCCGGA GCAGGGGCAT GGTCTAGTGG CCCAGTCACC ACGCGGAAAC 300
ACTCCCTGGA GGTTCTGACC CACTCCCTCT CAGCCTCCGC CTGGTCTCTG GTGTAGTCGC 360
CGCCGCCAGC CGCCATGGGC AAACAGAACA GCAAGCTGCG GCCCGAGGTG CTGCAGGACC 420
TGCGGGAGAA CACGGAGTTC ACCGACCACG AGCTGCAGGA GTGGTACAAG GGCTTCCTCA 480
AGGACTGCCC CACCGGCCAC CTGACCGTGG ACGAGTTCAA GAAGATCTAC GCCAACTTCT 540
TCCCCTACGG CGACGCTTCC AAGTTCGCCG AGCACGTCTT CCGCACCTTC GACACCAACG 600
GCGACGGCAC CATCGACTTC CGGGAGTTCA TCATTGCGCT GAGCGTGACC TCGCCCGGCA 660
AGCTGGAGCA GAAGCTCAAG TGGGCCTTCA GCATGTACGA CCTGGACGGC AACGGCTACA 720
TCAGCCGCAG CGAGATGCTG GAGATCGTGC AGGCCATCTA CAAGATGGTG TCGTCTGTGA 780 TGAAGATGCC GGAGGATGAG TCCACCCCGG AGAAGCGCAC AGACAAGATC TTCAGGCAGA 840
TGGACACCAA CAATGACGGC AAACTGTCCT TGGAAGAATT CATCAGAGGT GCCAAGAGCG 900
ACCCCTCCAT CGTCCGCCTG CTGCAGTGCG ACCCCAGCAG TGCCAGTCAG TTCTGAGCGA 960
GCGGCCCCTG GACAGTTGCA GAGAAACACA GGCTTGTCGT GCCGTTTAAG CTTTGCTTGC 1020
AAGAGTGGAT GCCCCGCAAT CGTTCCTGCT CTCCCGGGCC CCGGGCCTGG GGCATGCGTT 1080
GCACCTGCCC GGCCCGGTGG CTGCGCCTCC CTCCTCCACC TGACCAACGC GACATTCCTC 1140
CCCTCACGCC TGGCCCGGTC CCTTCCAGGG CAACTCCCAG GGATGTGGTG ACATGCAGGG 1200
TTCAAGTGTT CTTGGTTCCA GGCACCTCCC GGCTCACGGG GAGCTCAGAG GTCCATGCCG 1260
AGGAGACCAG GCAGGACCTC CCGAGGCTGC GCCCCGGCCG GCCCATGCGT TTTGTGATCC 1320
CAAGTGACTC TGTGGGAAGG GTGGGGACGA GGCGTCGGGA GGGTATACAG GGAGCCCCTC 1 80
CCGTGCATGG CTGCCCCCCC GTTCATTTTC TCCACCACAG CCGCTTGCAC GTATAGATAC 1440
TGTGGTCCCC TTTCTTTTAA TATATAAATT ATGTATGGTG AAGTGGAGTG TATTGTGTAG 1500
GTCCCGTATT TAATGCCTCT GACTGCCTTT GAAGCGCAGC CCTCTGTGGC CCGCAGCCCC 1560
CTGAGCCTGG CTGTTGTGTG GTATTTATGC TCTCTTTGTC TGCCTGTTTC TAAGGAAATG 1620
CATGTGTGCC CTGAGCCGTG ATGATCCTCC CATCCGTGTT GTGAGCACAG GCATTTGTGT 1680
CTGGTCTGTC CTCCCTGTTG ATTGGTCTGG CATTTCCGGT ATTAAAATGA TAAAATAAAT 1740
GGCATTTTCT GAAAAAAAAA AAAAAAAAA 1769
Seq ID NO 97 DNA Sequence
Nucleic Acid Accession ^ Eos sequence
1 11 21 31 41 51
I I I I I I
GCTGACTCTG AGGACCCCGT GGACATTAAA GAAAAATGAA CAGGTTTTTC TTAAAGCACC 60
AACCTGCTCT TTAACAAAAA TTATGAAAGG TTAAAAΛGAG TCTATAAAAA CTTACCTTAT 120
GGTCAAACAT GAAAAATTGG ATAAATATGT CTACAAGGTT TTATTAAAAT TAAGTTTAAC 180
ATTAATAACA CACTAATATA AAGGTAAAAT TTAGCTTATC TGGTATAAAA GTCATACAGG 240
AAGCATTAGT AAATATAAAA TAGCGTTTAG CTTTCTTTTG TCTAAAAACT AATAAAAATT 300
GGTGCTAAAG GAAGCATTCA TTTTACTAGA GGATCATAAA AGTTAAAGAC TTAAAACAAA 360
CTTTGGCAAT TAAGACAGCA TACCAAGATG CAAATGCCTG GTTGAAATGG ATCAAATATT 420
CCATCTGCAG GTTAAACAAA AGCAATTAGC ATGCTTGTGC ACATGGCAGG CCAGAGACCC 480
TGATTGTCCC CCTTCCACTA AGGTGGTCCT CCAGTCGACC AGGCATGGGC TGCATGGTAG 540
CTCTTTTCCA GGATTCTACA GCCTGGAGTA ATAAGTCATG CCAAGCTCTC TCTGCTATAT 600
CCTGAAGTCC CTGCGGGTCA GCCCCCGAGG GCCATCCAGC TTCCGTCTCC CAACACTAAG 660
TTCACTTCTT GTCTCTCATG GCAGGGAGGA GACTTAGCAT TCCTTGGAGA CCTGAAGGGA 720
TGCAGTGAGC TTAAGAATTT TCAAGAGCTT ATCAATCAGT CAGCCCTTGT TCATCCCCGA 780
GCGGATGTGT GGTGGTATTG TGGTGGACCT TTATTGGGCA CTCTGCCGAA TAACTAGAGT 840
GGCACTTGTG CTTTAGCCTA TTTGGCTATC CCTTTCACCC TGGCATTTCA TCAACCAGAG 900
GAAGGAAAAA AAAAATAATA AGACATCGTA AAGCGAGAGA AGCCCCTTAT GGGTCTTTCA 960
ACTCTCACAT CTATTTAGAT GCAATCGAAG CCCCGCAAGG AACACCAGAT CAATTTAAAG 1020
TCCGAAATCA AATAGCTACA GGATTTAAGT CAATATTTTG GTAGATGACA GTCAATAAAA 1080
ATGTAGATTA GATAAACTGC ATCTATTACA CCCAACAGCA ATGAGCTTTT CATGAGTTGA 1140
AAAAAAGAAA AACTCATGTC GGCCCCAGCC CTGAGGCTAC CTGACCTGAC AAAACTCTTT 1200
ACACTCTATG TGTCAGAAAG AGAAAAAATG GCAGTTGGAG TTTTAACCCA GACTGTAGGG 1260
CCCTGGCCAA GGCCAGTGGC CTATCTCTCA AAACAACTAG ACGGGGTTTC CAAAGGCTGG 1320
CCCCCATGTC CAAGGGCCCT GGCAGCAATA GCCCTGTTAG CACAAGAAGC AGATAAGCTA 1380
ACTCTTAGGC AAAACCTAAA CATAAAGTCC CCCCATGCTG TGGTAACTTT AATAAATACC 1440
AAAGGACATC ATTAGCTAAT GAATGCTAGA CTGACTGACT AGATACCAAA GCTTGCTCTG 1500
TGAAAATCCC TGCATAACCG TCGAAGTTTG CAACACCCTA AACCCAGCCA CCTTACTCCT 1560
GGTATCAGAG AGCCCAGTTG AACATAACTG TGTAGAGTTA TTGGACTCAG TTTATTCTAG 1620
TGGGTCCAAC TCCAAGACCA TCCTTAAACA TCAGTAGACT GGGAGCTGTA CGTGGATGGG 1680
AGCACGTTCG CCAACCCCTG CAAAGTGATT CTGAAGAAGA CGACAAGCGC TGCTCCAGTC 1740
ACACCCGGAA GCTGACTGGT CCACTCATGG CCGAGCATGA GGAAACTCAT CGCGGGACTC 1800
ATTTTCCTTA AAATTTGGAC TTGCACAGTA AGGACTTCAA CTGACCTTCC TCAGACTGAG 1860
GACTGTTCCC AGGATATACA TCAAGTCACT GAGGTAGGGA AAAAAGGTTG CTACAGTCCT 1920
ATTATTTTAT AGTTATTATG AATGCCTAGG AACTCCAAAA GGAACTTGTT TGTACAATAA 1980
CACTCAGTAC AAAGTATGTA ATCCAGGAAG TGACCAGCCT GAAGCGTGTT ATGACTCACT 2040
GTAAGCCTCC CATGATTAAG GACTGATCCT TTTCTAAGTG ACAGAAGTAG AGTAATAGCT 2100
AAAAAAAAAA AAAAAAAAGT CGAGC 2125
Seq ID NO 98 DNA Sequence
Nucleic Acid Accession tt NM_003946 2
Coding sequence 98 724
1 11 21 31 41 51
I I I I I I
GGCACGAGGG AGAGGCAGGA GGACACCGAG TTCCCCGTGT TGGCCTCCAG GTCCTGTGCT 60
TGCGGAGCCG TCCGGCGGCT GGGATCGAGC CCCGACAATG GGCAACGCGC AGGAGCGGCC 120
GTCAGAGACT ATCGACCGCG AGCGGAAACG CCTGGTCGAG ACGCTGCAGG CGGACTCGGG 180
ACTGCTGTTG GACGCGCTGC TGGCGCGGGG CGTGCTCACC GGGCCAGAGT ACGAGGCATT 240
GGATGCACTG CCTGATGCCG AGCGCAGGGT GCGCCGCCTA CTGCTGCTGG TGCAGGGCAA 300
GGGCGAGGCC GCCTGCCAGG AGCTGCTACG CTGTGCCCAG CGTACCGCGG GCGCGCCGGA 360 CCCCGCTTGG GACTGGCAGC ACGTGGGTCC GGGCTACCGG GACCGCAGCT ATGACCCTCC 420
. ATGCCCAGGC CACTGGACGC CGGAGGCACC CGGCTCGGGG ACCACATGCC CCGGGTTGCC 480
CAGAGCTTCA GACCCTGACG AGGCCGGGGG CCCTGAGGGC TCCGAGGCGG TGCAATCCGG 540
GACCCCGGAG GAGCCAGAGC CAGAGCTGGA AGCTGAGGCC TCTAAAGAGG CTGAACCGGA 600
5 GCCGGAGCCA GAGCCAGAGC TGGAACCCGA GGCTGAAGCA GAACCAGAGC CGGAACTGGA 660
GCCAGAACCG GACCCAGAGC CCGAGCCCGA CTTCGAGGAA AGGGACGAGT CCGAAGATTC 720
CTGAAGGCCA GAGCTCTGAC AGGCGGTGCC CCGCCCATGC TGGATAGGAC CTGGGATGCT 780
GCTGGAGCTG AATCGGATGC CACCAAGGCT CGGTCCAGCC CAGTACCGCT GGAAGTGAAT 840
AAACTCCGGA GGGTCGGACG GGACCTGGGC TCTCTCCACG ATTCTGGCTG TTTGCCCAGC 900
1 0 AACTTAGGGT GGGTACCTCT GAGTCCCAGG GACCTGGGCA GGCCCAAGCC CACCACGAGC 960
ATCATCCAGT CCTCAGCCCT AATCTGCCCT TAGGAGTCCA GGCTGCACCC TGGAGATCCC 1020
AAACCTAGCC CCCTAGTGGG ACAAGGACCT GACCCTCCTG CCCGCATACA CAACCCATTT 1080
CCCCTGGTGA GCCACTTGGC AGCATATGTA GGTACCAGCT CAACCCCACG CAAGTTCCTG 1140
AGCTGAACAT GGAGCAAGGG GAGGGTGACT TCTCTCCACA TAGGGAGGGC TTAGAGCTCA 1200
15 CAGCCTTGGG AAGTGAGACT AGAAGAGGGG AGCAGAAAGG GACCTTGAGT AGACAAAGGC 1260
CACACACATC ATTGTCATTA CTGTTTTAAT TGTCTGGCTT CTCTCTGGAC TGGGAGCTCA 1320
GTGAGGATTC TGACCAGTGA CTTACACAAA AGGCGCTCTA TACATATTAT AATATATTCG 1380
CTTACTAAAT GAAAAAAAAA AAAAAAAAAA A 1411
20 Seq ID NO : 99 DNA Sequence
Nucleic Acid Accession tt : NM_004207 . ι
Coding sequence : 63 . . 1460
1 11 21 31 41 51
~_- I I I I I I GGCGAGAGGC GGGCTGAGGC GGCCCAGCGG CGGCAGGTGA GGCGGAACCA ACCCTCCTGG 60
CCATGGGAGG GGCCGTGGTG GACGAGGGCC CCACAGGCGT CAAGGCCCCT GACGGCGGCT 120
GGGGCTGGGC CGTGCTCTTC GGCTGTTTCG TCATCACTGG CTTCTCCTAC GCCTTCCCCA 180
AGGCCGTCAG TGTCTTCTTC AAGGAGCTCA TACAGGAGTT TGGGATCGGC TACAGCGACA 240
CAGCCTGGAT CTCCTCCATC CTGCTGGCCA TGCTCTACGG GACAGGTCCG CTCTGCAGTG 300
30 TGTGCGTGAA CCGCTTTGGC TGCCCCCCCG TCATGCTTGT GGGGGGTCTC TTTGCGTCGC 360
TGGGCATGGT GGCTGCGTCC TTTTGCCGGA GCATCATCCA GGTCTACCTC ACCACTGGGG 420
TCATCACGGG GTTGGGTTTG GCACTCAACT TCCAGCCCTC GCTCATCATG CTGAACCGCT 480
ACTTCAGCAA GCGGCGCCCC ATGGCCAACG GGCTGGCGGC AGCAGGTAGC CCTGTCTTCC 540
TGTGTGCCCT GAGCCCGCTG GGGCAGCTGC TGCAGGACCG CTACGGCTGG CGGGGCGGCT 600
35 TCCTCATCCT GGGCGGCCTG CTGCTCAACT GCTGCGTGTG TGCCGCACTC ATGAGGCCCC 660
TGGTGGTCAC GGCCCAGCCG GGCTCGGGGC CGCCGCGACC CTCCCGGCGC CTGCTAGACC 720
TGAGCGTCTT CCGGGACCGC GGCTTTGTGC TTTACGCCGT GGCCGCCTCG GTCATGGTGC 780
TGGGGCTCTT CGTCCCGCCC GTGTTCGTGG TGAGCTACGC CAAGGACCTG GGCGTGCCCG 840
ACACCAAGGC CGCCTTCCTG CTCACCATCC TGGGCTTCAT TGACATCTTC GCGCGGCCGG 900
40 CCGCGGGCTT CGTGGCGGGG CTTGGGAAGG TGCGGCCCTA CTCCGTCTAC CTCTTCAGCT 960
TCTCCATGTT CTTCAACGGC CTCGCGGACC TGGCGGGCTC TACGGCGGGC GACTACGGCG 1020
GCCTCGTGGT CTTCTGCATC TTCTTTGGCA TCTCCTACGG CATGGTGGGG GCCCTGCAGT 1080
TCGAGGTGCT CATGGCCATC GTGGGCACCC ACAAGTTCTC CAGTGCCATT GGCCTGGTGC 1140
TGCTGATGGA GGCGGTGGCC GTGCTCGTCG GGCCCCCTTC GGGAGGCAAA CTCCTGGATG 1200
45 CGACCCACGT CTACATGTAC GTGTTCATCC TGGCGGGGGC CGAGGTGCTC ACCTCCTCCC 1260
TGATTTTGCT GCTGGGCAAC TTCTTCTGCA TTAGGAAGAA GCCCAAAGAG CCACAGCCTG 1320
AGGTGGCGGC CGCGGAGGAG GAGAAGCTCC ACAAGCCTCC TGCAGACTCG GGGGTGGACT 1380
TGCGGGAGGT GGAGCATTTC CTGAAGGCTG AGCCTGAGAA AAACGGGGAG GTGGTTCACA 1440
CCCCGGAAAC AAGTGTCTGA GTGGCTGGGC GGGGCCGGCA GGCACAGGGA GGAGGTACAG 1500
50 AAGCCGGCAA CGCTTGCTAT TTATTTTACA AACTGGACTG GCTCAGGCAG GGCCACGGCT 1560
GGGCTCCAGC TGCCGGCCCA GCGGATCGTC GCCCGATCAG TGTTTTGAGG GGGAAGGTGG 1620
CGGGGTGGGA ACCGTGTCAT TCCAGAGTGG ATCTGCGGTG AAGCCAAGCC GCAAGGTTAC 1680
AAGGCATCCT CACCAGGGGC CCCGCCTGCT GCTCCCAGGT GGCCTGCGGC CACTGCTATG 1740
CTCAAGGACC TGGAAACCCA TGCTTCGAGA CAACGTGACT TTAATGGGAG GGTGGGTGGG 1800
55 CCGCAGACAG GCTGGCAGGG CAGGTGCTGC GTGGGGCCCT CTCCAGCCCG TCCTACCCTG 1860
GGCTCACATG GGGCCTGTGC CCACCCCTCT TGAGTGTCTT GGGGACAGCT CTTTCCACCC 1920
CTGGAAGATG GAAATAAACC TGCGTGTGGG TGGAGTGTTC TCGTGCCGAA TTCAAAAAGC 1980
TT 1982
60 Seq ID NO: 100 DNA Sequence
Nucleic Acid Accession ii : NM_018325.1
Coding sequence: 163..1590
1 11 21 31 41 51
65 I I I I I I
ACGTGGTACG GAACCGGCGC CGCGCTTGCT GCTGGTAACA GGGCCTTGCC TAGTGGGCCT 60
TCCTTCCCAG GTCGCCCCTC AGTCTCCACT AGAGACAGGA CTGACCAGTT GCTCTTCCTT 120
CCAAGAACCT TCGAGATCTG CGGTCTGGGG TCTGGTTGAA AGATGGCGGC CCTCACTACC 180
CTGTTTAAGT ACATAGATGA AAATCAGGAT CGCTACATTA AGAAACTCGC AAAATGGGTG 240
GCTATCCAGA GTGTGTCTGC GTGGCCGGAG AAGAGAGGCG AAATCAGGAG GATGATGGAA 300
70 GTTGCTGCTG CAGATGTTAA GCAGTTGGGG GGCTCTGTGG AACTCCTGGA TATCCCAAAA 360
CAAAAGCTCC CTGATGGCTC GGAGATCCCG CTCCCTCCTA TTCTGCTCGG CAGGCTGGGC 420
TCCGACCCAC AGAAGAAGAC CGTGTGCATT TACGGGCACC TGGATGTGCA GCCTGCAGCC 480
CTGGAGGACG GCTGGGACAG CGAGCCCTTC ACCCTGGTGG AGCGAGACGG CAAGCTGTAT 540
GGGAGAGGTT CGACTGATGA TAAGGGCCCG GTGGCCGGCT GGATAAACGC CCTGGAAGCG 600
75 TATCAGAAAA CAGGCCAGGA GATTCCTGTC AACGTCCGAT TCTGCCTCGA AGGCATGGAG 660
GAGTCAGGCT CTGAGGGCCT AGACGAGCTG ATTTTTGCCC GGAAAGACAC ATTCTTTAAG 720
GATGTGGACT ATGTCTGCAT TTCTGACAAT TACTGGCTGG GAAAGAAGAA GCCCTGCATC 780
ACCTACGGCC TCAGGGGCAT TTGCTACTTT TTCATCGAGG TGGAGTGCAG CAACAAAGAC 840
CTCCATTCTG GGGTGTACGG GGGCTCGGTG CATGAGGCCA TGACTGATCT CATTTTGCTG 900
80 ATGGGCTCTT TGGTGGACAA GAGGGGGAAC ATCCTGATCC CCGGCATTAA CGAGGCCGTG 960
GCCGCCGTCA CGGAAGAGGA GCACAAGCTG TACGACGACA TCGACTTTGA CATAGAGGAG 1020
TTTGCCAAGG ATGTGGGGGC GCAGATCCTC CTGCACAGCC ACAAGAAAGA CATCCTCATG 1080
CACCGATGGC GGTACCCGTC TCTGTCCCTC CATGGCATCG AAGGCGCCTT CTCTGGGTCT 1140
GGGGCCAAGA CCGTGATTCC CAGGAAGGTG GTTGGCAAGT TCTCCATCAG GCTCGTGCCG 1200 AACATGACTC CTGAAGTCGT CGGCGAGCAG GTCACAAGCT ACCTAACTAA GAAGTTTGCT 1260
GAACTACGCA GCCCCAATGA GTTCAAGGTG TACATGGGCC ACGGTGGGAA GCCCTGGGTC 1320
TCCGACTTCA GTCACCCTCA TTACCTGGCT GGGAGAAGAG CCATGAAGAC AGTTTTTGGT 1380
GTTGAGCCAG ACTTGACCAG GGAAGGCGGC AGTATTCCCG TGACCTTGAC CTTTCAGGAG 1440
GCCACGGGCA AGAACGTCAT GCTGCTGCCT GTGGGCTCAG CGGATGACGG AGCCCACTCC 1S00
CAGAATGAAA AGCTCAACAG GTATAACTAC ATAGAGGGAA CCAAGATGCT GGCCGCGTAC 1560
CTGTATGAGG TCTCCCAGCT GAAGGACTAG GCCAAGCCCT CTGTGTGCCA TCTCCAATGA 1620
GAAGGAATCC TGCCCTCACC TCACCCTTTT CCAACTTGCC CAGGGAAGTG GAGGTTCCCT 1680
CTTTCCTTTC CCTCTTGTCA GGTCATCCAT GACTTTAGAG AACAGACACA AGTGTATCCA 1740
GCTGTCCACG GGTGGAGCTA CCCGTTGGGC TTATGAGTGA CCTGGAGTGA CAGCTGAGTC 1800
ACCCTGGGTA AGTTCTCAGA GTGGTCAGGA TGGCTTGACC TGCAGAAGAT ACCCAAGGTC 1860
CAAAAGCACA AGGTCTGCGG AAAGTTCTGG TTGTCGGCTG GGCACCACGG CTCACACCTA 1920
TAATCGAGCA CTTTGGGAGG CCAAGACAGG AGGATCACTT GAGGCCAGGA GTCTGAGACA 1980
AGCCTAGGCA ACAAAACAAG ACTCTGTCTC TACAAAAAGT TTAAGAAATG AGCCAGACAT 2040
GGTGGTGTAT GCCTGTAGTC CCAGCCACTC AGAAGGCTGA GGCAGGAGGA TCGCTTGAGA 2100
CCAAGAGTTT GAGCCTGCGG TGAGCTGTGA ATGCACCACG GCACTCAAGC CTGGGCAATG 2160
TAGCAAGATC CTGTCTCTAC AAGAAATTTT TTAAAAATGA GCCAAGTGTG GTGGTGCATG 2220
CCTGTAGTTC CAGCTACTCA GGACACTGAC GTAGGAGGGT TGCTTGAGAC TGAGAGTTGG 2280
AGGCTGCGAT GAGCCATGAA TGCCCCACTG CACTCCAGCC TGGGCGACAG AACGAGACCC 2340
CATCTCAAAA AAAATAAGTT CTGGTTGTCA TTGAATTGGG ATAAACAGAG AGCTTGATGC 2400
TTTCTGCCTT CTGTCTCAGG TGATGCATTG CACATTTGGG ATATTTGGAA AGGAAATGAG 2460
GAAAGAAATT AGGGCCTCCT CTGATCTCTC GCTATCTGCG GGTCCTGTCC TTTTCTCAAG 2520
ACCTTCACCA TTACTGGCAT TTTCCTGTCT TCTCTTTAGT ATGATCCCTC AAAACCTCAC 2580
TAACTGGAAG GATGATTTTG TCTCAGTTTG TACTCCTAAA TAAAAAGTAA ACATGACACC 2640
TCT 2643
Seq ID NO: 101 DNA Sequence
Nucleic Acid Accession tt : AF258592
Coding sequence 93..1268
1 11 21 31 41 51
I I I I I I
GTCGCCCCTC AGTCTCCACT AGAGACAGGA CTGACCAGTT GCTCTTCCTT CCAAGAACCT 60
TCGAGATCTG CGGTCTGGGG TCTGGTTGAA AGATGGCGGC CCTCACTACC CTGTTTAAGT 120
ACATAGATGA AAATCAGGAT CGCTACATTA AGAAACTCGC AAAATGGGTG GCTATCCAGA 180
GTGTGTCTGC GTGGCCGGAG AAGAGAGGCG AAATCAGGAG GATGATGGAA GTTGCTGCTG 240
CAGATGTTAA GCAGTTGGGG GGCTCTGTCC AACTGGTGGA TATCCCAAAA CAAAAGGAGA 300
TTCCTGTCAA CGTCCGATTC TGCCTCGAAG GCATGGAGGA GTCAGGCTCT GAGGGCCTAG 360
ACGAGCTGAT TTTTGCCCGG AAAGACACAT TCTTTAACCA TGTGGACTAT GTCTGCATTT 420
CTGACAATTA CTGGCTGGGA AAGAAGAAGC CCTGCATCAC CTACGGCCTC AGGGGCATTT 480
GCTACTTTTT CATCGAGGTG GAGTGCAGCA ACAAAGACCT CCATTCTGGG GTGTACGGGG 540
GCTCGGTGCA TGAGGCCATG ACTGATCTCA TTTTGCTGAT GGGCTCTTTG GTGGACAAGA 600
GGGGGAACAT CCTGATCCCC GGCATTAACG AGGCCGTGGC CGCCGTCACG GAAGAGGAGC 660
ACAAGCTGTA CGACGACATC GACTTTGACA TAGAGGAGTT TGCCAAGGAT GTGGGGGCGC 720
AGATCCTCCT GCACAGCCAC AAGAAAGACA TCCTCATGCA CCGATGGCGG TACCCGTCTC 780
TGTCCCTCCA TGGCATCGAA GGCGCCTTCT CTGGGTCTGG GGCCAAGACC GTGATTCCCA 840
GGAAGGTGGT TGGCAAGTTC TCCATCAGGC TCGTGCCGAA CATGACTCCT GAAGTCGTCG 900
GCGAGCAGGT CACAAGCTAC CTAACTAAGA AGTTTGCTGA ACTACGCAGC CCCAATGAGT 960
TCAACCTGTA CATCCGCCAC GGTGGGAAGC CCTGGGTCTC CGACTTCAGT CACCCTCATT 1020
ACCTGGCTGG GAGAAGAGCC ATGAAGACAG TTTTTGGTGT TGAGCCAGAC TTGACCAGGG 1080
AAGGCGGCAG TATTCCCGTG ACCTTGACCT TTCAGGAGGC CACGGGCAAG AACGTCATGC 1140
TGCTGCCTGT GGGGTCAGCG GATGACGGAG CCCACTCCCA GAATGAAAAG CTCAACAGGT 1200
ATAACTACAT AGAGGGAACC AAGATGCTGG CCGCGTACCT GTATGAGGTC TCCCAGCTGA 1260
AGGACTAGGC CAAGCCCTCT GTGTGCCATC TCCAATGAGA AGGAATCCTG CCCTCACCTC 1320
ACCCTTTTCC AACTTGCCCA GGGAAGTGGA GGTTCCCTCT TTCCTTTCCC TCTTGTCAGG 1380
TCATCCATGA CTTTAGAGAA CAGACACAAG TGTATCCAGC TGTCCACGGG TGGAGCTACC 1440
CGTTGGGCTT ATGAGTGACC TGGAGTGACA GCTGAGTCAC CCTGGGTAAG TTCTCAGAGT 1500
GGTCAGGATG GCTTGACCTG CAGAAGATAC CCAAGGTCCA AAAGCACAAG GTCTGCCCAA 1560
AGTTCTGGTT GTCGGCTGGG CACCACGGCT CACACCTATA ATCGAGCACT TTGGGAGGCC 1620
AAGACAGGAG GATCACTTGA GGCCAGGAGT CTGAGACAAG CCTAGGCAAC AAAACAAGAC 1680
TCTGTCTCTA CAAAAAGTTT AAGAAATGAG CCAGACATGG TGGTGTATGC CTGTAGTCCC 1740
AGCCACTCAG AAGGCTGAGG CAGGAGGATC GCTTGAGACC AAGAGTTTGA GCCTGCGGTG 1800
AGCTGTGAAT GCACCACGGC ACTCAAGCCT GGGCAATGTA GCAAGATCCT GTCTCTACAA 1860
GAAATTTTTT AAAAATGAGC CAAGTGTGGT GGTGCATGCC TGTAGTTCCA GCTACTCAGG 1920
ACACTGACGT AGGAGGGTTG CTTGAGACTG AGAGTTGGAG GCTGCGATGA GCCATGAATG 1980
CCCCACTGCA CTCCAGCCTG GGCGACAGAA CGAGACCCCA TCTCAAAAAA AATAAGTTCT 2040
GGTTGTCATT GAATTGGGAT AAACAGAGAG CTTGATGCTT TCTGCCTTCT GTCTCAGGTG 2100
ATGCATTGCA CATTTGGGAT ATTTGGAAAG GAAATGAGGA AAGAAATTAG GGCCTCCTCT 2160
GATCTCTCGC TATCTGCGGG TCCTGTCCTT TTCTCAAGAC CTTCACCATT ACTGGCATTT 2220
TCCTGTCTTC TCTTTAGTAT GATCCCTCAA AACCTCACTA ACTG AAGGA TGATTTTGTC 2280
TCAGTTTGTA CTCCTAAATA AAAAGTAAAC ATGACACCTC TAAAAAAAAA AAAAAAAAAA 2340
AAAAAAAAA 2349
Seq ID NO: 102 DNA Sequence
Nucleic Acid Accession . Eos sequence
1 11 21 31 41 SI
I I I I I I
TTTTTTACAA AGGGACTTAA AATTGTCAGG ATGATGGCAT ATCATCAGTG AGATGCTTCT 60
ACGTTGATGT GCACTTGTGT ATGCATGTAT TATACATACC CTCATGATGG GAACTGGAGT 120
CAATAATTTT CTTTTCTTTC TTTAGGACAC TTTCCTAGAT CTTTCCACTG TTAACCCAAC 180
CATCCAGATC TCCTAAACTC TCCTGAGAAC TTAGAAATTA ACTCCTTTCC TCTTCCCTAT 240
TTGGCTGCGC TAATAGAGCA GGCATGCAAT ACTAAGCTTC ACAGCTAGGT GTCCTCATAA 300
TGCAATGACT TCCTTTGGCA GCCTAGTCAT TGACAGCTGA CTTTGAGTCA AGAAAGTAAG 360
TTTTCTCTCT CCTTTATGTT TAATTTCTAT TTAGGGAGAT TCCTTATGAG GGATACTTAT 420
GAAGGCCACT TTCCTCCTGC TATGTGCTCA GAGCTAACTC CATATTTTCC TGTAAGTTTA 480 TAAGTAGCTT GCAATTCAGT TAGGTGTCCA CCAATG 516
Seq ID NO 103 DNA Sequence
Nucleic Acid Accession tt NM_018401 1
Coding sequence 65 1309
1 11 21 31 41 51
I I I I I I
GTCCCACATC CCGCATCCGG CATCCCAGCG GCCGGGCATG TAGCAGCGGC AGCAACGGCG 60
GAATATGGGC GGGAACCACT CCCACAAGCC CCCCGTGTTT GACGAGAATG AGGAAGTCAA 120
CTTTGACCAT TTTCAGATTC TGCGGGCCAT TGGTAAACCG AGTTTTGGAA AGGTATGCAT 180
CGTGCAGAAG CGAGACACTA AGAAAATGTA TGCAATGAAG TACATGAACA AGCAGAAGTG 240
CATCGAGAGG GATGAGGTTC GGAATGTTTT CCGGGAGCTG CAGATCATGC AAGGGCTGGA 300
GCACCCCTTC CTGGTCAATC TGTGGTACTC CTTCCAGGAT GAGGAGGACA TGTTCATGGT 360
GGTGGACCTG CTCCTCCGAG GCGACCTGCG CTACCATCTG CAGCAGAATG TGCATTTCAC 420
AGAGGGGACT GTGAAACTCT ACATCTGTGA GCTGGCACTG GCCCTGGAGT ATCTTCAGAG 480
GTACCACATC ATCCACAGAG ACATCAAGCC AGACAATATC CTGCTGGATG AACACGGACA 540
TGTTCACATT ACAGACTTCA ACATAGCGAC GGTAGTGAAA GGAGCAGAAA GGGCTTCCTC 600
CATGGCTGGC ACCAAGCCCT ACATGGCTCC AGAAGTATTC CAGGTGTACA TGGACAGAGG 660
CCCCGGATAC TCGTACCCTG TCGACTGGTG GTCCCTGGGC ATCACAGCCT ATGAGCTGCT 720
GCGGGGCTGG AGGCCGTACG AAATCCACTC GGTCACGCCC ATCGATGAAA TCCTCAACAT 780
GTTCAAGGTG GAGCGTGTCC ACTACTCCTC CACGTGGTGC AAGGGGATGG TGGCCCTGCT 840
GAGGAAGCTC CTGACCAAGG ATCCTGAGAG CCGCGTGTCC AGCCTTCATG ACATACAGAG 900
CGTGCCCTAC TTGGCCGACA TGAACTCCGA CGCGGTGTTC AAGAAGGCAC TGATGCCCCC 960
CTTTGTGCCC AATAAAGGGA GGTTGAACTG CGATCCCACA TTTGAGCTTG AAGAGATGAT 1020
TCTAGAATCC AAGCCACTTC ACAAAAAGAA GAAGCGATTG GCAAAGAACA GATCCAGGGA 1080
TGGCACAAAG GACAGCTGCC CGCTGAATGG ACACCTGCAG CACTGTTTCC AGACTGTCCG 1140
GGAGGAATTC ATCATATTCA ACAGAGAGAA GCTCAGGAGG CAGCAGGGAC AGGGCAGCCA 1200
GCTCTTGGAC ACCGACAGCC GAGGGGGAGG CCAGGCCCAA AGCAAGCTCC AGGACGGGTG 1260
CAACAACAAC CTCCTCACCC ACACCTGCAC CCGTGGCTGC AGCAGCTGAG CCCACACTTG 1320
TTGCTGCTCA ACAGGACTGC ACTCGTCTCT GCCCTGCCCA CCCAGAGCCC CTCTTTGTGC 1380
CCTGATGGTC CCTGTCTCAC CCCTGAAAAC ATCAGATGCA GAAAAAGCCC TGGACTTGGA 1440
GCTGGGAAGC CTGGGTTCTG GTCCCATCTC CATGACTGAT TCACGTGTGA CCTCAGACAA 1500
GTCACGCCCT CTCTGTGCCT CCGTTTTCTG CATCTGCCAA AGGGGTTAAA CACTTCTGCC 1560
CCACTTCAAA TTACAAGATT ATGGGGAGAA CCCAATTAGG TAGGAAACAT GAAAAACCTT 1620
TGATATTTAT AAAATCATTT TTACGTGCAA AATATAACCT TAATATTTGA AGTGACCCCC 1680
ATTCCCCAAA GCAATCAAAC CGTCATGACT TTGCAATTTG GCACATCCTA GCTTGTTAGA 1740
GGGCACTTCC GAAAAACACA GCCCTGACAG CAAAATAAAG GTCTGATATG TTGGCCCCTT 1800
CTATGGAAAC AACGCTGCCA AATCCTGGAG CAAAACCTGA AGTGTCTTCA TGTGCATTCT 1860
CTGGCAGGCC ACAGTCCTGA GCTTGTAAGA TGGTGCAGCA TGCAGACCAG ACTTGTCCCC 1920
AAGGTCTCAG CGCTGCCCTC TCACTCCTCC CCTCATTTAA GAAGACTATC CTTACCTTTT 1980
AGTTTCAGCA GTCCTCACCA CCACCATATC CCCAGTGCTG GGATGGCACA CAGGTGTCCA 2040
TTCAGATGAG AGTTGGGTCG CTGAGCATTG GTTACTCCTG CAGAGTGTAA TCAGCACCCC 2100
ATCCAACTGG CCCGAAAGCC CAGACCTGCA GCAGAACTCT CCAACTCTCT ATCAGCTTTC 2160
AGGGTTTTCT CTCCTGGGAA GGGTGTAAAA TCAGCTTGTC AGATTCTTCT TACAGAGAGT 2220
ATCCAATCGG TATTGGTGGA GCGGCTCCCT ATTTATACAA TAGGAAGCAT GGGTGCTTAG 2280
AAAGTTTATT TCAGGAGGAA AATGGGTTCA CACAAAAAGC AAACTACATT CTGATCTGCT 2340
CAGGGAGAAG CTTGCCTTTG AACTGGAAGA TGTTGGGATG AGCAGGGAAA GCTTAGACTT 2400
TGGAGTCAGG TTTGTGTTCA GAATCCAGCC CTGCTGGCTA CTAACTAACT GGGAGACCTT 2460
AGGCAAAGCA TGCAATCGCT CTGAATGGCA GTTTCCTCAT TTTTAAACAG GGATAATAAA 2520
ACTAATATTG CAGGGGAGTT ACAGGGTTAA ATAAGATCCT GTGTGTAACC CCAAGCATTG 2580
GATGACTCAT AGAATGGCCT TTTTTGTCAG CATAATCGTC ATCATTATTT AGATACTTTC 2640
TTCCTTCACT CACCCAGCAG GTCAGTTTTC TGTGCAAACA AACCTGTTTA GGATTCTTCC 2700
AAATGTTCTT CCTGGGGTCT TTGATATTTG TTTGTTACAT CCTGCTGAAG TTCGACTGTG 2760
TTTTTATTTT TTCATCCAAC TTCCATTTTT CACTTTTTAC ATGATTACTC AATCCTTGGG 2820
GCTGTCCATG TCATCTCTTA GATTTCTTAA AAGACATTTT AATGTATGGT TAGGTTTTAT 2880
ATTTTTATTT TTTAAAAAAG AAATAGTCAG TGTTTTCCTC CTTTCAACCG AGACTATTTC 2940
TGGATTGTGT GCTCCTCGTC AGTTGACTTG TTTTGCACAC TTTTCTTTAC TTCATGTCCC 3000
CATCAACAAC CGTCCTGCTC CCCACCTCCC CCAGGAAATA AGGGGCCTGC TCCTCTCCCT 3060
ACTGTGACCC TGGAGGCTCT TAAGATGATG ATGGTTTTTT TTATTGGGCT GAGTTCACGA 3120
ATTACCGGCA GGAGCTGGAA GTCGCCCTAG GAACACCAGA TTTCCTGGTT CTGTTCAAGT 3180
TGGCATTTCT TGTTTGGAAT AAACTATTTC TTGGACATTC CTTC 3224
Seq ID NO 104 DNA Sequence
Nucleic Acid Accession tt NM_004207 1
Coding sequence 63 1460
1 11 21 31 41 51
I I I I I I
GGCGAGAGGC GGGCTGAGGC GGCCCAGCGG CGGCAGGTGA GGCGGAACCA ACCCTCCTGG 60
CCATGGGAGG GGCCGTGGTG GACGAGGGCC CCACAGGCGT CAAGGCCCCT GACGGCGGCT 120
GGGGCTGGGC CGTGCTCTTC GGCTGTTTCG TCATCACTGG CTTCTCCTAC GCCTTCCCCA 180
AGGCCGTCAG TGTCTTCTTC AAGGAGCTCA TACAGGAGTT TGGGATCGGC TACAGCGACA 240
CAGCCTGGAT CTCCTCCATC CTGCTGGCCA TGCTCTACGG GACAGGTCCG CTCTGCAGTG 300
TGTGCGTGAA CCGCTTTGGC TGCCGGCCCG TCATGCTTGT GGGGGGTCTC TTTGCGTCGC 360
TGGGCATGGT GGCTGCGTCC TTTTGCCGGA GCATCATCCA GGTCTACCTC ACCACTGGGG 420
TCATCACGGG GTTGGGTTTG GCACTCAACT TCCAGCCCTC GCTCATCATG CTGAACCGCT 480
ACTTCAGCAA GCGGCGCCCC ATGGCCAACG GGCTGGCGGC AGCAGGTAGC CCTGTCTTCC 540
TGTGTGCCCT GAGCCCGCTG GGGCAGCTGC TGCACCACCG CTACGGCTGG CGGGGCGGCT 600
TCCTCATCCT GGGCGGCCTG CTGCTCAACT GCTGCGTGTG TGCCGCACTC ATGAGGCCCC 660
TGGTGGTCAC GGCCCAGCCG GGCTCGGGGC CGCCGCGACC CTCCCGGCGC CTGCTAGACC 720
TGAGCGTCTT CCGGGACCGC GGCTTTGTGC TTTACGCCGT GGCCGCCTCG GTCATGGTGC 780
TGGGGCTCTT CGTCCCGCCC GTGTTCGTGG TGAGCTACGC CAAGGACCTG GGCGTGCCCG 840
ACACCAACCC CGCCTTCCTG CTCACCATCC TGGGCTTCAT TGACATCTTC GCGCGGCCGG 900
CCGCGGGCTT CGTGGCGGGG CTTGGGAAGG TGCGGCCCTA CTCCGTCTAC CTCTTCAGCT 960
TCTCCATGTT CTTCAACGGC CTCGCGGACC TGGCGGGCTC TACGGCGGGC GACTACGGCG 1020 GCCTCGTCCT CTTCTGCATC TTCTTTGGCA TCTCCTACGG CATGGTGGGG GCCCTGCAGT 1080
TCGAGGTGCT CATGGCCATC GTGGGCACCC ACAAGTTCTC CAGTGCCATT GGCCTGGTGC 1140
TGCTGATGGA GGCGGTGGCC GTGCTCGTCG GGCCCCCTTC GGGAGGCAAA CTCCTGGATG 1200
CGACCCACGT CTACATGTAC GTGTTCATCC TGGCGGGGGC CGAGGTGCTC ACCTCCTCCC 1260 TGATTTTGCT GCTGGGCAAC TTCTTCTGCA TTAGGAAGAA GCCCAAAGAG CCACAGCCTG 1320
AGGTGGCGGC CGCGGAGGAG GAGAAGCTCC ACAAGCCTCC TGCAGACTCG GGGGTGGACT 1380
TGCGGGAGGT GGAGCATTTC CTGAAGGCTG AGCCTGAGAA AAACGGGGAG GTGGTTCACA 1440
CCCCGGAAAC AAGTGTCTGA GTGGCTGGGC GGGGCCGGCA GGCACAGGGA GGAGGTACAG 1500
AAGCCGGCAA CGCTTGCTAT TTATTTTACA AACTGGACTG GCTCAGGCAG GGCCACGGCT 1560 GGGCTCCAGC TGCCGGCCCA GCGGATCGTC GCCCGATCAG TGTTTTGAGG GGGAAGGTGG 1620
CGGGGTGGGA ACCGTGTCAT TCCAGAGTGG ATCTGCGGTG AAGCCAAGCC GCAAGGTTAC 1680
AAGGCATCCT CACCAGGGGC CCCGCCTGCT GCTCCCAGGT GGCCTGCGGC CACTGCTATG 1740
CTCAAGGACC TGGAAACCCA TGCTTCGAGA CAACGTGACT TTAATGGGAG GGTGGGTGGG 1800
CCGCAGACAG GCTGGCAGGG CAGGTGCTGC GTGGGGCCCT CTCCAGCCCG TCCTACCCTG 1860 GGCTCACATG GGGCCTGTGC CCACCCCTCT TGAGTGTCTT GGGGACAGCT CTTTCCACCC 1920
CTGGAAGATG GAAATAAACC TGCGTGTGGG TGGAGTGTTC TCGTGCCGAA TTCAAAAAGC 1980
TT 1982
Seq ID NO 105 DNA Sequence
Nucleic Acid Accession tt NM_006598 1
Coding sequence 5 3256
1 11 21 31 41 51
I I I I I I
AGCCATGCCC ACGAACTTTA CGGTGGTGCC CGTGGAGGCT CACGCCGACG GCGGCGGGGA 60
CGAGACTGCC GAGCGGACGG AGGCTCCGGG CACCCCCGAG GGCCCCGAGC CCGAGCGCCC 120
CAGCCCGGGA GATGGAAATC CAAGAGAAAA CAGCCCATTC CTCAACAATG TCGAGGTGGA 180
ACAAGAGAGC TTCTTTGAAG GGAAGAACAT GGCACTTTTC GAGGAGCAGA TGGACAGTAA 240
CCCCATGGTG TCCTCGCTGC TCAACAAGCT GGCCAACTAC ACCAACCTGA GCCAGGGCGT 300
CCTGGAGCAC GAGGAGGACG AGGAGAGCCG GCGGCGGGAG GCCAAGGCTC CGCGCATGGG 360
CACCTTCATC GGCGTCTACC TGCCGTGCCT GCAGAACATC CTGGGCGTCA TCCTCTTCCT 420
GCGCCTGACG TGGATCGTGG GGGTGGCTGG TGTCCTGGAG TCCTTCCTCA TCGTGGCCAT 480
GTGCTGCACA TGTACAATGC TGACCGCCAT TTCCATGAGT GCGATCGCTA CCAACGGTGT 540
GGTCCCAGCT CCCGGGTCCT ACTACATGAT ATCGCGCTCG CTGGGACCCG AGTTTGGAGG 600
CGCTGTCGGC CTCTGCTTCT ACCTGGGCAC GACGTTTGCA GGGGCCATGT ATATTTTGGG 660 GACCATCGAG ATTTTTCTGA CGTACATCTC CCCGGGTGCG GCCATCTTCC AGGCGGAGGC 720
TGCAGGTGGC GAGGCGGCCG CCATGCTGCA CAACATGCGT GTGTACGGCA CGTGCACGCT 780
CGTGCTCATG GCCCTGGTGG TCTTCGTGGG CGTCAAGTAT GTCAACAAGC TGGCGCTGGT 840
CTTCCTGGCC TGCGTCGTGC TGTCCATCCT GGCCATCTAT GCCGGCGTCA TCAAGTCTGC 900
CTTCGACCCC CCGGACATCC CGGTCTGCCT CCTGGGGAAC CGCACGCTGT CACGGCGCAG 960
CTTCGATGCC TGCGTCAAGG CCTACGGCAT CCACAACAAC TCAGCCACCT CCGCGCTCTG 1020
GGGCCTCTTC TGCAACGGCT CCCAGCCCAG CGCCGCCTGT GACGAGTACT TCATCCAGAA 1080
CAACGTCACC GAAATCCAGG GCATCCCGGG CGCGGCCAGT GGTGTCTTCC TGGAGAACCT 1140
GTGGAGTACG TACGCGCACG CGGGGGCGTT TGTGGAGAAG AAAGGTGTGC CCTCGGTGCC 1200
CGTGGCAGAG GAGAGCCGTG CCAGCACACT GCCCTACGTG CTCACCGACA TCGCGGCCTC 1260
CTTCACCCTG CTGCTTGGCA TCTACTTCCC TTCCGTGACC GGTATCATGG CGGGTTCAAA 1320
CCGGTCCGGG GACCTCAAGG ATGCACAGAA GTCCATCCCC ACGGGGACCA TCCTGGCCAT 1380
AGTGACGACG TCTTTCATCT ATCTCTCCTG CATTGTGCTG TTTGGGGCCT GCATTGAAGG 1440
CGTGGTCTTA CGAGATAAGT TCGGGGAGGC CCTGCAGGGG AACCTGGTCA TCGGCATGCT 1500
GGCCTGGCCC TCCCCCTGGG TCATCGTCAT CGGCTCCTTC TTCTCCACCT GCGGTGCCGG 1560
CCTGCAGACC CTCACGGGGG CACCGCGCCT ACTGCAGGCC ATTGCCCGTG ACGGCATCGT 1620
CCCCTTCCTG CAGGTGTTTG GCCACGGGAA GGCCAACGGG GAGCCCACGT GGGCGCTGCT 1680
GCTGACAGTC CTCATCTGCG AGACTGGCAT CCTCATCGCC TCTCTGGACA GCGTGGCCCC 1740
GATCCTCTCC ATGTTCTTCC TCATGTGCTA CCTGTTCGTG AACCTGGCCT GCGCCGTGCA 1800
GACCCTGCTA CGTACCCCCA ACTGGCGTCC ACGCTTCAAG TTCTACCACT GGACCCTGTC 1860
CTTTCTGGGT ATGAGCCTGT GCCTGGCGCT GATGTTCATC TGCTCCTGGT ACTACGCGCT 1920
GTCCGCCATG CTCATCGCTG GCTGCATCTA CAAGTACATC GAGTACCGCG GGGCCGAGAA 1980
GGAGTGGGGC GATGGCATCC GTGGCCTATC CCTGAACGCC GCCCGCTACG CCCTGCTGCG 2040
CGTGGAGCAC GGTCCCCCCC ACACCAAGAA CTGGAGGCCC CAGGTGCTGC TGATGCTGAA 2100
CCTGGACGCG GAGCAGGCCG TGAAGCACCC CCGCCTGCTG TCCTTCACGT CGCAGCTGAA 2160
GGCCGGCAAG GGCCTGACCA TCGTGGGCTC GGTGCTGGAG GGGACGTACC TGGACAAGCA 2220
CATGGAGGCT CAGCGGGCCG AGGAGAACAT ACGGTCCCTA ATGAGCACAG AGAAGACCAA 2280
CCGCTTCTGC CAGCTGGTGG TCTCGTCCAG CCTGCGGGAT GGCATGTCCC ACCTGATCCA 2340
GTCGGCCGGC CTGGGCGGCC TGAAGCACAA CACGGTGCTC ATGGCCTGGC CCGCATCCTG 2400
GAAGCAGGAG GACAACCCCT TCTCCTGGAA GAACTTTGTA GACACCGTCC GCGACACCAC 2460
CGCCGCGCAC CAGGCTCTGC TGGTGGCCAA GAACGTCGAC TCGTTTCCGC AAAACCAGGA 2520
GCGCTTCCCC GGGGGCCACA TCGACGTGTG GTGGATCGTG CACGACGGCG GCATGCTCAT 2580
GCTGCTGCCC TTCCTGCTGC GCCAGCACAA GGTGTGGAGG AAGTGCCGGA TGCGTATCTT 2640
CACCGTGGCC CAGGTGGACG ACAACAGCAT CCAGATGAAG AAGGACCTGC AGATGTTCTT 2700
GTATCACTTG CGCATCAGCG CCGAGGTGGA GGTGGTGGAG ATGGTTGAAA ACGACATATC 2760
TGCTTTCACC TACGAGAGGA CACTAATGAT GGAGCAGAGG TCGCAGATGC TGAAGCAGAT 2820
GCAGCTGTCC AAGAACGAGC AGGAGCGAGA GGCCCAGCTG ATCCACGACA GGAACACCGC 2880
GTCCCACACC GCGGCGGCAG CCAGGACCCA AGCGCCGCCT ACGCCAGACA AGGTGCAGAT 2940
GACCTGGACC ACCGAGAAGC TGATCGCTGA GAAGTACAGG AGCAGAGACA CCAGCCTATC 3000
CGGTTTCAAA GACCTCTTCA GCATGAAGCC GGACCAGTCC AACGTCAGGC GGATGCACAC 3060
GGCTGTGAAG CTCAATGGCG TCGTCCTCAA CAAGTCCCAG GATGCGCAGC TGGTCCTGCT 3120
CAACATGCCA GGTCCTCCCA AAAACCGGCA GGGAGACGAG AACTACATGG AGTTTCTTGA 3180
AGTCCTGACC GAGGGGCTGA ACAGAGTCCT CCTGGTCAGG GGTGGCGGCC GGGAGGTGAT 3240 CACCATCTAC TCCTAATGCC CAACAGCATC ACGGCACTCT GGGACAGGCA CGGAGGACGG 3300 CGTGGGCAGC CTGGGCCTGG GCTTGGCCCA GGGAACCAGA CGGCAGACAC ACCTGTCCCC 3360
CAGTGATGCC ACCCAAGCTG CCCATGGGGC TTCCTACGGA AGTTTCTAGG CCCGTCACCT 3420 AGGGCTCTCC TGTTCAGCCT TAACAGCCTC AGCAAATCAG GGCGTGGCTG GACGATTTCC 3480
TTGCATCTGA GGGCAGACGC TGCTACCGGA GTGACCTGGA CGTGGCCAGA TCTTCTCGCA 3540 GGTCACAAGA AGCCAGTGAG CCCTTGCCTT GGTTTCTGGA AGTTCTTTTC CTTGGCTGGA 3600 TTTACCCAGT GGTTAGGTTG CATTTCTACC CCATCCAGAA CATTCTTGGA AGAGCACCCG 3660 GAGCTGAAGC TGTCCCTGAT GATGAAGGTG AAACGTCAGC CCTGGCCATG GCTCCGCTCA 3720
GGGCCCCGGT CACCTCCGAG TCACTCTGTT CCTTGACTGT CTTTGTGTTT CTGTACCTCA 3780
AGGCACTGAA GCTCCAGGAC TCTGTCCATG CCCGTGTCAC CCTCGTGTGG GAGCCTCTGG 3840
GCTCGGCAGG TCCACATTTC ATGAGCTGAG GCGTGGGCCA GGGCCATCTG GAAAGGGAAC 3900
TCCCCTTTTC CAGAACGTGG TGGATCATCT GTCGGGTGTG TGGTGAACAC GTTCAGTTCA 3960
TCAGGGCCTA CGCTCCGGGA AGGGGCCCCC AGCTGTGGCT CTGCCATGCC GGGCTGTGTT 4020
TGCAGCTGTC CGAGTCTCCA TCCACCTTTA GAAAACCAGT CACTTCTTTT CATAAGCACT 4080
GACACCGCCC AGCCCACAGC CACAGGTGCG ATCAGTGCCT CACGCAGGCA AATGCACTGA 4140
AACCCAGGGG CACACGCGCG CAGAGTGAAC AGTGAGTTCC CCCGACAGCC CACGACAGCC 4200
AGGACTGCCC TCCCCACCCC ACCCCACCCC AGGAGCACGG CACACAGTTC AGCCTCTGAG 4260
CTGGCTCACA CGTGCCATCC CCACCCCGGT GCTCCAGGGA AGGAGGACAC GGACCCGACG 4320
TGGGAGGTCC TCAGGCAGCA GTGGCGCCTG GTGTCAGGTC TGTCTGGCTG AGTCCCGGGC 4380
GTCCCCTGCC ATGGCCTGTG CCTTGCATGG AGGCGGCGGT GGCACTGAAG AGATAGCTTT 4440
CAAGGGCCCA ACACTTTGCA CTTCGGCTGG CTGTGAGTTT CTGCTTTGTA GGTTGTGGTC 4500
ACATTTGCAG GCTGCGGGCA GTGGCACCGA CTTGGGCCTC CCTTTCTATG TGGCATATTT 4560
ATTTATTTAA ACACCCCAGG GAGTTACGTG GTAACAAGGT TGTCCATAAA GAGGTTGCTT 4620
CTATATACTA GAGGCCCCAG ATGGCAGGCC TTGGGCTACG TCTGGCTTGC ATGGTCTCCC 4680
AAGGGAATCA ACCCCATCAA CAAAGTTCAA ATCGGGGCAG AGGCTGCACT TGTGCCCCCA 4740
GATGTTTCTG AGGAGCCAGA TTAGGGCTGG CATTGCTGTA GAGTGACGGC TGCTGCCCAG 4800
AGCGTGTCCC AGACATCACA GCGGGGCTCA GCAGTTCCCA CAGCCTCTGC CTGCCTTGGC 4860
TAAGCATGAG TTAAGCAGCA AAACGCTCCT CCATGTCTGG ATGGGGCCGG CAGGTCCTGT 4920
GTCCCCTGCA CCTGGAGGAG AGCAGGCTAG AGGCACAGCG GCCACATGGT GCTGGCTCTG 4980
AACGTTGGTT GGTGGCTGGA AAACAGCCCT GCTTCTGAGG GCCGCTCAGT TCTGCACACG 5040
AAACCACCTC CTGAGGGCTC AGCTCTGCCC CCGCCCTGGG CTGCAGCCTC TGCACGCAAG 5100
CACCAGGCAT CCTTTGTGTT GTCAACTCCG TGTAACCAGT AACTACAGCC ATTTACAATT 5160
GACTCCGTTT CCTTTTGTAG GTTTCCCTGT CTGTCTGTGT TAGTAGAAAA ATAAAATCCT 5220
ATGAAATCTG AAAAAAAAA 5239
Seq ID NO: 106 DNA Sequence
Nucleic Acid Accession tt ■ N _00458S
Coding sequence: 62..556
1 11 21 31 41 51
I I I I I I
CCTTCAGCAT AAAAGCTGAT CCACAAACAA GAGGAGCACC AGACCTCCTC TTGGCTTCGA 60
GATGGCTTCG CCACACCAAG AGCCCAAACC TGGAGACCTG ATTGAGATTT TCCGCCTTGG 120
CTATGAGCAC TGGGCCCTGT ATATAGGAGA TGGCTACGTG ATCCATCTGG CTCCTCCAAG 180
TGAGTACCCC GGGGCTGGCT CCTCCAGTGT CTTCTCAGTC CTGAGCAACA GTGCAGAGGT 240
GAAACGGGGG CGCCTGGAAG ATGTGGTGGG AGGCTGTTGC TATCCCGTCA ACAACAGCTT 300
GGACCATGAG TACCAACCAC GGCCCGTCCA GGTGATCATC AGTTCTGCGA AGGAGATGGT 360
TGGTCAGAAG ATGAAGTACA GTATTGTGAG CAGGAACTGT GAGCACTTTG TCGCCCAGCT 420
GAGATATGGC AAGTCCCGCT GTAAACAGGT GGAAAAGGCC AAGGTTGAAG TCGGTGTGGC 480
CACGGCGCTT GGAATCCTGG TTGTTGCTGG ATGCTCTTTT GCGATTAGGA GATACCAAAA 540
AAAAGCAACA GCCTGAAGCA GCCACAAAAT CCTGTGTTAG AAGCAGCTGT GGGGGTCCCA 600
GTGGAGATGA GCCTCCCCCA TGCCTCCAGC AGCCTGACCC TCGTGCCCTG TCTCAGGCGT 660
TCTCTAGATC CTTTCCTCTG TTTCCCTCTC TCGCTGGCAA AAGTATGATC TAATTGAAAC 720
AAGACTGAAG GATCAATAAA CAGCCATCTG CCCCTTCAAA AAAAAAAA 768
Seq ID NO: 107 DNA Sequence
Nucleic Acid Accession tt : NM_004696.1
Coding sequence: 183..1646
1 11 21 31 41 51
I I I I I I
CTTGGCTCTT ACAATGCTCA CTTGTTTTCA CAATGCAGCA AAATGAAATG CCTTAGAAAA 60
AGAGTAACAT TCCAGAAAAC GGTGTAATTT ATTTTTCTTC CTTAATTGCC CCATCTGTGG 120
AGGATTTCTT TGCTGAACAC CACATCAAAG GGATCTTCTG CATTTAAAAT AGAAGAGGCA 180
TCATGCTGAA GAGGGAGGGG AAGGTCCAAC CTTACACTAA AACCCTGGAT GGAGGATGGG 240
GATGGATGAT TGTGATTCAT TTTTTCCTGG TGAATGTGTT TGTGATGGGG ATGACCAAGA 300
CTTTTGCAAT TTTCTTTGTG GTCTTTCAAG AAGAGTTTGA AGGCACCTCA GAGCAAATTG 360
GTTGGATTGG ATCCATCATG TCATCTCTTC GTTTTTGTGC AGGTCCCCTG GTTGCTATTA 420
TTTGTGACAT ACTTGGAGAG AAAACTACCT CCATTCTTGG GGCTTTCGTT GTTACTGGTG 480
GATATCTGAT CAGCAGCTGG GCCACAAGTA TTCCTTTTCT TTGTGTGACT ATGGGACTTC 540
TACCCGGTTT GGGTTCTGCT TTCTTATACC AAGTGGCTGC TGTGGTAACT ACCAAATACT 600
TCAAAAAACG ATTGGCTCTT TCTACAGCTA TTGCCCGTTC TGGGATGGGA CTGACTTTTC 660
TTTTGGCACC CTTTACAAAA TTCCTGATAG ATCTGTATGA CTGGACAGGA GCCCTTATAT 720
TATTTGGAGC TATCGCATTG AATTTGGTGC CTTCTAGTAT GCTCTTAAGA CCCATCCATA 780
TCAAAAGTGA GAACAATTCT GGTATTAAAG ATAAAGGCAG CAGTTTGTCT GCACATGGTC 840
CAGAGGCACA TGCAACAGAA ACACACTGCC ATGAGACAGA AGAGTCTACC ATCAAGGACA 900
GTACTACGCA GAAGGCTGGA CTACCTAGCA AAAATTTAAC AGTCTCACAA AATCAAAGTG 960
AAGAGTTCTA CAATGGGCCT AACAGGAACA GACTGTTATT AAAGAGTGAT GAAGAAAGTG 1020
ATAAGGTTAT TTCGTGGAGC TGCAAACAAC TGTTTGACAT TTCTCTCTTT AGAAATCCTT 1080
TCTTCTACAT ATTTACTTGG TCTTTTCTCC TCAGTCAGTT AGCATACTTC ATCCCTACCT 1140
TTCACCTGGT AGCCAGAGCC AAAACACTGG GGATTGACAT CATGGATGCC TCTTACCTTG 1200
TTTCTGTAGC AGGTATCCTT GAGACGGTCA GTCAGATTAT TTCTGGATGG GTTGCTGATC 1260
AAAACTGGAT TAAGAAG AT CATTACCACA AGTCTTACCT CATCCTCTGC GGCATCACTA 1320
ACCTGCTTGC TCCTTTAGCC ACCACATTTC CACTACTTAT GACCTACACC ATCTGCTTTG 1380
CCATCTTTGC TGGTGGTTAC CTGGCATTGA TACTGCCTGT ACTGGTTGAT CTGTGTAGGA 1440
ATTCTACAGT AAACACCTTT TTGGGACTTG CCAGTTTCTT TGCTGGGATG GCTGTCCTTT 1500
CTGGACCACC TATAGCAGGC TGGTTATATG ATTATACCCA GACATACAAT GGCTCTTTCT 1560
ACTTCTCTGG CATATGCTAT CTCCTCTCTT CAGTTTCCTT TTTTTTTGTA CCATTGCCCG 1620
AAAGATGGAA AAACAGTCTG ACCTGAAAGA AAGAAGACTG CAATCAAGTG AGAGCTAAAC 1680
AAAAGAAAAC CTAAACTAAT GTCATTGGAA ACAAAAGCTT GAAAGAAACA CATCGCATCT 1740
ACATTTGTAA CATGAGAAGG AAAACAATTT TTTTTTTTTT TTTTTTGAGA CGGAGTCTCG 1800
CTCTTTCGCC CAGGCTGGAG TGCAGTGGCG CAATCTCGGC TCACTGTAAT CTCCGCCTCC 1860
TGGGTTCAAG GGATTCTCCT GCCTCAGCCT CCCAAGTAGC TGGGACTACA GGCACACGCC 1920 ACCACACCCA GCTAATTTTT TGTATTTTTA GTAGAGGCCC GGTTTCACCA TGTTAGCCAG 1980
GATGGTCTCC ATCTCCTGAC CTCGTGATCC GCCCGCCTTG TCCTCCAAAG TGCTGGGATT 2040
ACAGGCATGA GCCACTGGGC GCGGCCAGAT AAGTTTTTAA GGTTCCTTCT TGCTTTAGCA 2100
TTCTGAGAAA TGTCTAATTG GTAGTAAGAC AAGAGTAATA GCAACCTGTA TTGTTAGTAT 2160 TTAACCAAAT ACCCTAAAAT TTTAATCAGG TACCTTATGT ATTAAATAGA AATCGGAATG 2220
TACCATAATA AATCCAAACT CTCAATTACG CCATGGTAAT TCAGTCACTA AAATATGTAA 2280
AGATAGAAAA TTTTTTAATT TAAAGAAGTG TGAAACATAG CCATTGATTG ATCAGAATTC 23 0
TGGAATCTGA ATATTAAAAC CTTACTTAGT GACTGGAATG GTATATGCTC CCTCCAAAAG 2400
TTTATCTTTG TTTATTGATT AAAGGTAATC CTTACTTTCT TTGTATTACT TAGGTTCTCA 2460 ATTAAAGGTA ATCCTTACTT TCTTTGTATT ACTTAGGTTC TTAAATTTCT ATGATAAACA 2520
TGTATTGCT 2529
Seq ID NO : 108 DNA Sequence Nucleic Acid Accession If : NM_000358 . 1 Coding sequence : 48 . .2099
1 11 21 31 41 51
GCTTGCCCGT CGGTCGCTAG CTCGCTCG T GCGCGTCGTC CCGCTCCATG GCGCTCTTCG 60
TGCGGCTGCT GGCTCTCGCC CTGGCTCTGG CCCTGGGCCC CGCCGCGACC CTGGCGGGTC 120
CCGCCAAGTC GCCCTACCAG CTGGTGCTGC AGCACAGCAG GCTCCGGGGC CGCCAGCACG 180
GCCCCAACGT GTGTGCTGTG CAGAAGGTTA TTGGCACTAA TAGGAAGTAC TTCACCAACT 240
GCAAGCAGTG GTACCAAAGG AAAATCTGTG GCAAATCAAC AGTCATCAGC TACGAGTGCT 300
GTCCTGGATA TGAAAAGGTC CCTGGGGAGA AGGGCTGTCC AGCAGCCCTA CCACTCTCAA 360
ACCTTTACGA GACCCTGGGA GTCGTTGGAT CCACCACCAC TCAGCTGTAC ACGGACCGCA 420
CGGAGAAGCT GAGGCCTGAG ATGGAGGGGC CCGGCAGCTT CACCATCTTC GCCCCTAGCA 480
ACGAGGCCTG GGCCTCCTTG CCAGCTGAAG TGCTGGACTC CCTGGTCAGC AATGTCAACA 540
TTGAGCTGCT CAATGCCCTC CGCTACCATA TGGTGGGCAG GCGAGTCCTG ACTGATGAGC 600
TGAAACACGG CATGACCCTC ACCTCTATGT ACCAGAATTC CAACATCCAG ATCCACCACT 660
ATCCTAATG GATTGTAACT GTGAACTGTG CCCGGCTCCT GAAAGCCGAC CACCATGCAA 720
CCAACGGGGT GGTGCACCTC ATCGATAAGG TCATCTCCAC CATCACCAAC AACATCCAGC 780
AGATCATTGA GATCGAGGAC ACCTTTGAGA CCCTTCGGGC TGCTGTGGCT GCATCAGGGC 840
TCAACACGAT GCTTGAAGGT AACGGCCAGT ACACGCTTTT GGCCCCGACC AATGAGGCCT 900
TCGAGAAGAT CCCTAGTGAG ACTTTGAACC GTATCCTCCG CGACCCAGAA GCCCTCAGAG 960
ACCTGCTGAA CAACCACATC TTGAAGTCAG CTATGTGTGC TGAAGCCATC GTTGCGGGGC 1020
TGTCTGTAGA GACCCTGGAG GGCACGACAC TGGAGGTGGG CTGCAGCGGG GACATGCTCA 1080
CTATCAACGG GAAGGCGATC ATCTCCAATA AAGACATCCT AGCCACCAAC GCGGTGATCC 1140
ACTACATTGA TGAGCTACTC ATCCCAGACT CAGCCAAGAC ACTATTTGAA TTGGCTGCAG 1200
AGTCTGATGT GTCCACAGCC ATTGACCTTT TCAGACAAGC CGGCCTCGGC AATCATCTCT 1260
CTGGAAGTGA GCGGTTGACC CTCCTGGCTC CCCTGAATTC TGTATTCAAA GATGGAACCC 1320
CTCCAATTGA TGCCCATACA AGGAATTTGC TTCGGAACCA CATAATTAAA GACCAGCTCC 1380
CCTCTAAGTA TCTGTACCAT GGACAGACCC TGGAAACTCT GGGCGGCAAA AAACTGAGAG 1440
TTTTTGTTTA TCGTAATAGC CTCTGCATTG AGAACAGCTG CATCGCGGCC CACGACAAGA 1500
GGGGGAGGTA CGGGACCCTG TTCACGATGG ACCCCGTGCT GACCCCCCCA ATGGGGACTG 1560
TCATGGATGT CCTGAAGGGA GACAATCGCT TTAGCATGCT GGTAGCTGCC ATCCAGTCTG 1620
CAGGACTGAC GGAGACCCTC AACCGGGAAG GAGTCTACAC AGTCTTTGCT CCCACAAATG 1680
AAGCCTTCCG AGCCCTGCCA CCAAGAGAAC GGAGCAGACT CTTGGGAGAT GCCAAGGAAC 1740
TTGCCAACAT CCTGAAATAC CACATTGGTG ATGAAATCCT GGTTAGCGGA GGCATCGGGG 1800
CCCTGGTGCG GCTAAAGTCT CTCCAAGGTG ACAAGCTGGA AGTCAGCTTG AAAAACAATG 1860
TGGTGAGTGT CAACAAGGAG CCTGTTGCCG AGCCTGACAT CATGGCCACA AATGGCGTGG 1920
TCCATGTCAT CACCAATGTT CTGCAGCCTC CAGCCAACAG ACCTCACCAA AGAGGGGATG 1980
AACTTGCAGA CTCTGCGCTT GAGATCTTCA AACAAGCATC AGCGTTTTCC AGGGCTTCCC 2040
AGAGGTCTGT GCGACTAGCC CCTGTCTATC AAAAGTTATT AGAGAGGATG AAGCATTAGC 2100
TTGAAGCACT ACAGGAGGAA TGCACCACGG CAGCTCTCCG CCAATTTCTC TCAGATTTCC 2160
ACAGAGACTG TTTGAATGTT TTCAAAACCA AGTATCACAC TTTAATGTAC ATGGGCCGCA 2220
CCATAATGAG ATGTGAGCCT TGTGCATGTG GGGGAGGAGG GAGAGAGATG TACTTTTTAA 2280
ATCATGTTCC CCCTAAACAT GGCTGTTAAC CCACTGCATG CAGAAACTTG GATGTCACTG 2340
CCTGACATTC ACTTCCAGAG AGGACCTATC CCAAATGTGG AATTGACTGC CTATGCCAAG 2400
TCCCTGGAAA AGGAGCTTCA GTATTGTGGG GCTCATAAAA CATGAATCAA GCAATCCAGC 2460
CTCATGGGAA GTCCTGGCAC AGTTTTTGTA AAGCCCTTGC ACAGCTGGAG AAATGGCATC 2S20
ATTATAAGCT ATGAGTTGAA ATGTTCTGTC AAATGTGTCT CACATCTACA CGTGGCTTGG 2580
AGGCTTTTAT GGCGCCCTGT CCACCTAGAA AAGAAATGGT ATGTAGAGCT TAGATTTCCC 2640
TATTGTGACA GAGCCATGGT GTGTTTGTAA TAATAAAACC AAAGAAACAT A 2691
Seq ID NO : 109 DNA Sequence
Nucleic Acid Accession tt : NM_14S648
Coding sequence : 59 . . 1792
1 11 21 31 41 51
I I I I I I
CAGGTTGGGT TCTGGGACAG GTGACCCGGC GGCGGGGCGA GGCAGCTGGC GGCGTCGCAT 60
GGAGGGCTCT GGGGGCGGTG CGGGCGAGCG GGCGCCGCTG CTGGGCGCGC GGCGGGCGGC 120
GGCGGCCGCG GCCCCGGCTG GGGCGTTCGC GGGCCGGCGC GCGGCGTGCG GGGCCGTGCT 180
GCTGACGGAG CTGCTGGAGC GCGCCGCTTT CTACGGCATC ACGTCCAACC TCCTGCTATT 240
CCTGAACGGG GCGCCGTTCT GCTGGGAGGG CGCGCAGGCC AGCGAGGCGC TGCTGCTCTT 300
CATGGGCCTC ACCTACCTGG GCTCGCCGTT CGGAGGCTCC CTGGCCGACG CGCGGCTGGG 60
CCGGGCGCGC GCCATCCTGC TGAGCCTGGC GCTCTACCTG CTGGGCATGC TGGCCTTCCC 420
GCTGCTGGCC GCGCCCGCCA CGCGAGCCGC GCTCTGCCCT TCCGCGCGCC TGCTCAACTG 480
CACGGCGCCT GGTCCCGACG CCGCCGCCCG CTGCTGCTCA CCGGCCACCT TCGCGGGGCT 540
GGTGCTGGTG GGCCTGGGCG TGGCCACCGT CAAGGCCAAC ATCACGCCCT TCGGCGCCGA 600
CCAGGTTAAA GATCGAGGTC CGGAAGCCAC TAGGAGATTT TTTAATTGGT TTTATTGGAG 660
CATTAACCTG GGAGCGATCC TGTCGTTAGG TGGCATTGCC TATATTCAGC AGAACGTCAG 720
CTTTGTCACT GGTTATGCGA TCCCCACTGT CTGCGTCCCC CTTGCTTTTG TGGTCTTCCT 780
CTGTGGCCAG AGCGTTTTCA TCACCAAGCC TCCTGATGGC AGTGCCTTCA CCGACATGTT 840
CAAGATACTG ACGTATTCCT GCTGTTCCCA GAAGCGAAGT GGAGAGCGCC AGAGTAATGG 900
TGAAGGCATT GGAGTCTTTC AGCAATCTTC TAAACAAAGT CTGTTTGATT CATGTAAGAT 960 GTCTCATGGT GGGCCATTTA CAGAAGAGAA AGTGGAAGAT GTGAAAGCTC TGGTCAAGAT 1020
TGTCCCTGTT TTCTTGGCTT TGATACCTTA CTGGACAGTG TATTTCCAAA TGCAGACAAC 1080
ATATGTTTTA CAGAGTCTTC ATTTGAGGAT TCCAGAAATT TCAAATATTA CAACCACTCC 1140
TCACACGCTC CCTGCAGCCT GGCTGACCAT GTTTGATGCT GTGCTCATCC TCCTGCTCAT 1200
CCCTCTGAAG GACAAACTGG TCGATCCCAT TTTGAGAAGA CATGGCCTGC TCCCATCCTC 1260
CCTGAAGAGG ATCGCCGTGG GCATGTTCTT TGTCATGTGC TCGGCCTTTG CTGCACCAAT 1320
TTTGGAGAGT AAAAGGCTGA ACCTTGTTAA AGAGAAAACC ATTAATCAGA CCATCGGCAA 1380
CGTCGTCTAC CATGCTGCCG ATCTGTCGCT GTGGTGGCAG GTGCCGCAGT ACTTGCTGAT 1440
TGGGATCAGC GAGATCTTTG CAAGTATCGC AGGCCTGGAA TTTGCATACT CAGCTGCCCC 1500
CAAGTCCATG CAGAGTGCCA TAATGGGCTT GTTCTTTTTC TTCTCTGGCG TCGGGTCGTT 1560
CGTGGGTTCT GGACTGCTGG CACTGGTGTC TATCAAAGCC ATCGGATGGA TGAGCAGTCA 1620
CACAGACTTT GGTAATATTA ACGGCTGCTA TTTGAACTAT TACTTTTTTC TTCTGGCTGC 1680
TATTCAAGGA GCTACCCTCC TGCTTTTCCT CATTATTTCT GTGAAATATG ACCATCATCG 1740
AGACCATCAG CGATCAAGAG CCAATGGCGT GCCCACCAGC AGGAGGGCCT GACCTTCCTG 1800
AGGCCATGTG CGGTTTCTGA GGCTGACATG TCAGTAACTG ACTGGGGTGC ACTGAGAACA 1860
GGCAAGACTT TAAATTCCCA TAAAATGTCT GACTTCACTG AAACTTGCAT GTTGCCTGGA 1920
TTGATTTCTT CTTTCCCTCT ATCCAAAGGA GCTTGGTAAG TGCCTTACTG CAGCGTGTCT 1980
CCTGGCACGC TGGGCCCTCC GGGAGGAGAG CTGCAGATTT CGAGTATGTC GCTTGTCATT 2040
CAAGGTCTCT GTGAATCCTC TAGCTGGGTT CCCTTTTTTA CAGAAACTCA CAAATGGAGA 2100
TTGCAAAGTC TTGGGGAACT CCACGTGTTA GTTGGCATCC CAGTTTCTTA AACAAATAGT 2160
ATCACCTGCT TCCCATAGCC ATATCTCACT GTAAAAAAAA AAAATTAATA AACTGTTACT 2220
TATATTTAAG AAAGTGAGGA TTTTTTTTTT TTAAAGATAA AAGCATGGTC AGATGCTGCA 2280
AGGATTTTAC ATAAATGCCA TATTTATGGT TTCCTTCCTG AGAACAGTCT TGCTCTTGCC 2340
ATGTTCTTTG ATTTAGGCTG GTAGTAAACA CATTTCATCT GCTGCTTCAA AAAGTACTTA 2400
CTTTTTAAAC CATCAACATT ACTTTTCTTT CTTAAGGCAA GGCATGCATA AGAGTCATTT 2460
GAGACCATGT GTCCCATCTC AAGCCACAGA GCAACTCACA GGGTACTTCA CACCTTACCT 2520
AGTCAGAGTG CTTATATATA GCTTTATTTT GGTACGATTG AGACTAAAGA CTGATCATGG 2580
TTGTATGTAA GGAAAACATT CTTTTGAACA GAAATAGTGT AATTAAAAAT AATTGAAAGT 2640
GTTAAATGTG AACTTGAGCT GTTTGACCAG CCACATTTTT GTATTGTTAC TGTACGTGTA 2700
TCTGGGGCTT CTCCGTTTGT TAATACTTTT TCTGTATTTG TTGCTGTATT TTTGGCATAA 2760
CTTTATTATA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAA 2807
Seq ID NO : 110 DNA Sequence
Nucleic Acid Accession tt : NM_001250
Coding sequence : 48 . . 881
1 11 21 31 41 51
I I I I I I
GCCTCGCTCG GGCGCCCAGT GGTCCTGCCG CCTGGTCTCA CCTCGCCATG GTTCGTCTGC 60
CTCTGCAGTG CGTCCTCTGG GGCTGCTTGC TGACCGCTGT CCATCCAGAA CCACCCACTG 120
CATGCAGAGA AAAACAGTAC CTAATAAACA GTCAGTGCTG TTCTTTGTGC CAGCCAGGAC 180
AGAAACTGGT GAGTGACTGC ACAGAGTTCA CTGAAACGGA ATGCCTTCCT TGCGGTGAAA 240
GCGAATTCCT AGACACCTCC AACAGAGAGA CACACTGCCA CCAGCACAAA TACTGCGACC 300
CCAACCTAGG GCTTCCCGTC CAGCAGAAGG GCACCTCAGA AACAGACACC ATCTGCACCT 360
GTGAAGAAGG CTGGCACTGT ACGAGTGAGG CCTGTGAGAG CTGTGTCCTG CACCGCTCAT 420
GCTCGCCCGG CTTTGGGGTC AAGCAGATTG CTACAGGGGT TTCTGATACC ATCTGCGAGC 480
CCTGCCCAGT CGGCTTCTTC TCCAATGTGT CATCTGCTTT CGAAAAATGT CACCCTTGGA 540
CAAGCTGTGA GACCAAAGAC CTGGTTGTGC AACAGGCAGG CACAAACAAG ACTGATGTTG 600
TCTGTGGTCC CCAGGATCGG CTGAGAGCCC TCCTGGTGAT CCCCATCATC TTCGGGATCC 660
TGTTTGCCAT CCTCTTGGTG CTGGTCTTTA TCAAAAAGGT GGCCAAGAAG CCAACCAATA 720
AGGCCCCCCA CCCCAAGCAG GAACCCCAGG AGATCAATTT TCCCGACGAT CTTCCTGGCT 780
CCAACACTGC TGCTCCAGTG CAGGAGACTT TACATGGATG CCAACCGGTC ACCCAGGAGG 840
ATGGCAAAGA GAGTCGCATC TCAGTGCAGG AGAGACAGTG AGGCTGCACC CACCCAGGAG 900
TGTGGCCACG TGGGCAAACA GGCAGTTGGC CAGAGAGCCT CCTGCTGCTG CTGCAGGGGT 960
GCAGGCAGAA GCGGGGAGCT ATGCCCAGTC AGTGCCAGCC CCTC 1004
Seq ID NO : 111 DNA Sequence
Nucleic Acid Accession It : NM_00384 . 3
Coding sequence : 286 . . 1608
1 11 21 31 41 51 i i i i i i
GCGCTTGCGG AGGATTGCGT TGACGAGACT CTTATTTATT GTCACCAACC TGTGGTGGAA 60
TTTGCAGTTG CACATTGGAT CTGATTCGCC CCGCCCCGAA TGACGCCTGC CCGGAGGCAG 120
TGAAAGTACA GCCGCGCCGC CCCAAGTCAG CCTGGACACA TAAATCAGCA CGCGGCCGGA 180
GAACCCCGCA ATCTCTGCGC CCACAAAATA CACCGACGAT GCCCGATCTA CTTTAAGGGC 240
TGAAACCCAC GGGCCTGAGA GACTATAAGA GCGTTCCCTA CCGCCATGGA ACAACGGGGA 300
CAGAACGCCC CGGCCGCTTC GGGGGCCCGG AAAAGGCACG GCCCAGGACC CAGGGAGGCG 360
CGGGGAGCCA GGCCTGGGCT CCGGGTCCCC AAGACCCTTG TGCTCGTTGT CGCCGCGGTC 420
CTGCTGTTGG TCTCAGCTGA GTCTGCTCTG ATCACCCAAC AAGACCTAGC TCCCCAGCAG 480
AGAGCCCCCC CACAACAAAA GAGGTCCAGC CCCTCAGAGG GATTGTGTCC ACCTGGACAC 540
CATATCTCAG AAGACGGTAG AGATTGCATC TCCTGCAAAT ATGGACACCA CTATAGCACT 600
CACTGGAATG ACCTCCTTTT CTGCTTGCGC TGCACCAGGT GTGATTCAGG TGAAGTGGAG 660
CTAAGTCCCT GCACCACGAC CAGAAACACA GTGTGTCAGT GCGAAGAAGG CACCTTCCGG 720
GAAGAAGATT CTCCTGAGAT GTGCCGGAAG TGCCGCACAG GGTGTCCCAG AGGGATGGTC 780
AAGGTCGGTG ATTGTACACC CTGGAGTGAC ATCGAATGTG TCCACAAAGA ATCAGGTACA 840
AAGCACAGTG GGGAAGCCCC AGCTGTGGAG GAGACCCTGA CCTCCAGCCC AGGGACTCCT 900
GCCTCTCCCT GTTCTCTCTC AGGCATCATC ATAGGAGTCA CAGTTGCAGC CGTAGTCTTG 960
ATTGTGGCTG TGTTTGTTTG CAAGTCTTTA CTGTGGAAGA AAGTCCTTCC TTACCTGAAA 1020
GGCATCTGCT CAGGTGGTGG TGGGGACCCT GAGCGTGTGG ACAGAAGCTC ACAACGACCT 1080
GGGGCTGAGG ACAATGTCCT CAATGAGATC GTGAGTATCT TGCAGCCCAC CCAGGTCCCT 1140
GAGCAGGAAA TGGAAGTCCA GGAGCCAGCA GAGCCAACAG GTGTCAACAT GTTGTCCCCC 1200
GG GAGTCAG AGCATCTGCT GGAACCGGCA GAAGCTGAAA GGTCTCAGAG GAGGAGGCTG 1260
CTGGTTCCAG CAAATGAAGG TGATCCCACT GAGACTCTGA GACAGTGCTT CGATGACTTT 1320
GCAGACTTGG TGCCCTTTGA CTCCTGGGAG CCGCTCATGA GGAAGTTGGG CCTCATGGAC 1380
AATGAGATAA AGGTGGCTAA AGCTGAGGCA GCGGGCCACA GGGACACCTT GTACACGATG 1440 CTGATAAAGT GGGTCAACAA AACCGGGCGA GATGCCTCTG TCCACACCCT GCTGGATGCC 1500
TTGGAGACGC TGGGAGAGAG ACTTGCCAAG CAGAAGATTG AGGACCACTT GTTGAGCTCT 1560
GGAAAGTTCA TGTATCTAGA AGGTAATGCA GACTCTGCCA TGTCCTAAGT GTGATTCTCT 1620
TCAGGAAGTC AGACCTTCCC TGGTTTACCT TTTTTCTGGA AAAAGCCCAA CTGGACTCCA 1680
5 GTCAGTAGGA AAGTGCCACA ATTGTCACAT GACCGGTACT GGAAGAAACT CTCCCATCCA 1740
ACATCACCCA GTGGATGGAA CATCCTGTAA CTTTTCACTG CACTTGGCAT TATTTTTATA 1800
AGCTGAATGT GATAATAAGG ACACTATGGA AATGTCTGGA TCATTCCGTT TGTGCGTACT 1860
TTGAGATTTG GTTTGGGATG TCATTGTTTT CACAGCACTT TTTTATCCTA ATGTAAATGC 1920
TTTATTTATT TATTTGGGCT ACATTGTAAG ATCCATCTAC ACAGTCGTTG TCCGACTTCA 1980 0 CTTGATACTA TATGATATGA ACCTTTTTTG GGTGGGGGGT GCCCGGCAGT TCACTCTGTC 2040
TCCCAGGCTG GAGTGCAATG GTGCAATCTT GGCTCACTAT AGCCTTGACC TCTCAGGCTC 2100
AAGCGATTCT CCCACCTCAG CCATCCAAAT AGCTGGGACC ACAGGTGTGC ACCACCACGC 2160
CCGGCTAATT TTTTGTATTT TGTCTAGATA TAGGGGCTCT CTATGTTGCT CAGGGTGGTC 2220
TCGAATTCCT GGACTCAAGC AGTCTGCCCA CCTCAGACTC CCAAAGCGGT GGAATTAGAG 2280 5 GCGTGAGCCC CCATGCTTGG CCTTACCTTT CTACTTTTAT AATTCTGTAT GTTATTATTT 2340
TATGAACATG AAGAAACTTT AGTAAATGTA CTTGTTTACA TAGTTATGTG AATAGATTAG 2400
ATAAACATAA AAGGAGGAGA CATACAATGG GGGAAGAAGA AGAAGTCCCC TGTAAGATGT 2460
CACTGTCTCC GTTCCAGCCC TCCCTCAGAT GTACTTTGGC TTCAATGATT GGCAACTTCT 2520
ACAGGGGCCA GTCTTTTGAA CTGGACAACC TTACAAGTAT ATGAGTATTA TTTATAGGTA 2580 0 GTTGTTTACA TATGAGTCGG GACCAAAGAG AACTGGATCC ACGTGAAGTC CTGTGTGTGG 2640
CTGGTCCCTA CCTGGGCAGT CTCATTTGCA CCCATAGCCC CCATCTATGG ACAGGCTGGG 2700
ACAGAGGCAG ATGGGTTAGA TCACACATAA CAATAGGGTC TATGTCATAT CCCAAGTGAA 2760
CTTGAGCCCT GTTTGGGCTC AGGAGATAGA AGACAAAATC TGTCTCCCAC GTCTGCCATG 2820
GCATCAAGGG GGAAGAGTAG ATGGTGCTTG AGAATGGTGT GAAATGGTTG CCATCTCAGG 2880 5 AGTAGATGGC CCGGCTCACT TCTGGTTATC TGTCACCCTG AGCCCATGAG CTGCCTTTTA 2940
GGGTACAGAT TGCCTACTTG AGGACCTTGG CCGCTCTGTA AGCATCTGAC TCATCTCAGA 3000
AATGTCAATT CTTAAACACT GTGGCAACAG GACCTAGAAT GGCTGACGCA TTAAGGTTTT 3060
CTTCTTGTGT CCTGTTCTAT TATTGTTTTA AGACCTCAGT AACCATTTCA GCCTCTTTCC 3120
AGCAAACCCT TCTCCATAGT ATTTCAGTCA TGGAAGGATC ATTTATGCAG GTAGTCATTC 3180 0 CAGGAGTTTT TGGTCTTTTC TGTCTCAAGG CATTGTGTGT TTTGTTCCGG GACTGGTTTG 3240
GGTGGGACAA AGTTAGAATT GCCTGAAGAT CACACATTCA GACTGTTGTG TCTGTGGAGT 3300
TTTAGGAGTG GGGGGTGACC TTTCTGGTCT TTGCACTTCC ATCCTCTCCC ACTTCCATCT 3360
GGCATCCCAC GCGTTGTCCC CTGCACTTCT GGAAGGCACA GGGTGCTGCT GCCTCCTGGT 3420
CTTTGCCTTT GCTGGGCCTT CTGTGCAGGA CGCTCAGCCT CAGGGCTCAG AAGGTGCCAG 3480 5 TCCGGTCCCA GGTCCCTTGT CCCTTCCACA GAGGCCTTCC TAGAAGATGC ATCTAGAGTG 3540
TCAGCCTTAT CAGTGTTTAA GATTTGTCTT TTATTTTTAA TTTTTTTGAG ACAGAATCTC 3600
ACTCTCTCGC CCAGGCTGGA GTGCAACGGT ACGATCTTGG CTCAGTGCAA CCTCCGCCTC 3660
CTGGGTTCAA GCGATTCTCG TGCCTCAGCC TCCGGAGTAG CTGGGATTGC AGGCACCCGC 3720
CACCACGCCT GGCTAATTTT TGTATTTTTA GTAGAGACGG GGTTTCACCA TGTTGGTCAG 3780 0 GCTGGTCTCG AACTCCTGAC CTCAGGTGAT CCACCTTGGC CTCCGAAAGT GCTGGGATTA 3840
CAGGCGTGAG CCACCAGCCA CCCCAAGCTA TTCTTTTAAA GTAAGCTTCC TGACGACATG 3900
AAATAATTGG GGGTTTTGTT GTTTAGTTAC ATTAGGCTTT GCTATATCCC CACCCCAAAT 3960
AGCATGTGAC ACAGGACAGC CATAGTATAG TGTGTCACTC GTGGTTGGTG TCCTTTCATG 4020
CTTCTGCCCT GTCAAAGGTC CCTATTTGAA ATGTGTTATA ATACAAACAA GGAAGCACAT 4080 5 TGTGTACAAA ATACTTATGT ATTTATGAAT CCATGACCAA ATTAAATATG AAACCTTATA 4140
TAAAAAAAAA AAAAAAAAAA 4160
Seq ID NO : 112 DNA Sequence Nucleic Acid Accession tt : NM_147187 . 1 0 Coding sequence : 286 . . 1521
1 11 21 31 41 51
I I I I I I
GCGCTTGCGG AGGATTGCGT TGACGAGACT CTTATTTATT GTCACCAACC TGTGGTGGAA 60
TTTGCAGTTG CACATTGGAT CTGATTCGCC CCGCCCCGAA TGACGCCTGC CCGGAGGCAG 120 5 TGAAAGTACA GCCGCGCCGC CCCAAGTCAG CCTGGACACA TAAATCAGCA CGCCCCCGGA 180
GAACCCCGCA ATCTCTGCGC CCACAAAATA CACCGACGAT GCCCGATCTA CTTTAAGGGC 240
TGAAACCCAC GGGCCTGAGA GACTATAAGA GCGTTCCCTA CCGCCATGGA ACAACGGGGA 300
CAGAACGCCC CGGCCGCTTC GGGGGCCCGG AAAAGGCACG GCCCAGGACC CACCGAGGCG 360
CGCGGAGCCA GGCCTGGGCT CCGGGTCCCC AAGACCCTTG TGCTCGTTGT CGCCGCGGTC 420 0 CTGCTGTTGG TCTCAGCTGA GTCTGCTCTG ATCACCCAAC AAGACCTAGC TCCCCAGCAG 480
AGAGCCCCCC CACAACAAAA GAGGTCCAGC CCCTCAGAGG GATTGTGTCC ACCTGGACAC 540
CATATCTCAG AAGACGGTAG AGATTGCATC TCCTGCAAAT ATGGACAGGA CTATAGCACT 600
CACTGGAATG ACCTCCTTTT CTGCTTGCGC TGCACCAGGT GTGATTCAGG TGAAGTGGAG 660
CTAAGTCCCT GCACCACGAC CAGAAACACA GTGTGTCAGT GCGAAGAAGG CACCTTCCGG 720 5 GAAGAAGATT CTCCTGAGAT GTGCCGCAAG TGCCGCACAG GGTGTCCCAG AGGGATGGTC 780
AAGGTCGGTG ATTGTACACC CTGGAGTGAC ATCGAATGTG TCCACAAAGA ATCAGGCATC 840
ATCATAGGAG TCACAGTTGC AGCCGTAGTC TTGATTGTGG CTGTGTTTGT TTGCAAGTCT 900
TTACTGTGGA AGAAAGTCCT TCCTTACCTG AAAGGCATCT GCTCAGCTGG TGGTGGGGAC 960
CCTGAGCGTG TGGACAGAAG CTCACAACGA CCTGGGGCTG AGGACAATGT CCTCAATGAG 1020
70 ATCGTGAGTA TCTTGCAGCC CACCCAGGTC CCTGAGCAGG AAATGGAAGT CCAGGAGCCA 1080
GCAGAGCCAA CAGGTGTCAA CATGTTGTCC CCCGGGGAGT CAGAGCATCT GCTGGAACCG 1140
GCAGAAGCTG AAAGGTCTCA GAGGAGGAGG CTGCTGGTTC CAGCAAATGA AGGTGATCCC 1200
ACTGAGACTC TGAGACAGTG CTTCGATGAC TTTGCAGACT TGGTGCCCTT TGACTCCTGG 1260
GAGCCGCTCA TGAGGAAGTT GGGCCTCATG GACAATGAGA TAAAGGTGGC TAAAGCTGAG 1320
75 GCAGCGGGCC ACAGGGACAC CTTGTACACG ATGCTGATAA AGTGGGTCAA CAAAACCGGG 1380
CGAGATGCCT CTGTCCACAC CCTGCTGGAT GCCTTGGAGA CGCTGGGAGA GAGACTTGCC 1440
AAGCAGAAGA TTGAGGACCA CTTGTTGAGC TCTGGAAAGT TCATGTATCT AGAAGGTAAT 1500
GCAGACTCTG CCATGTCCTA AGTGTGATTC TCTTCAGGAA GTCAGACCTT CCCTGGTTTA 1560
O Λ CCTTTTTTCT GGAAAAAGCC CAACTGGACT CCAGTCAGTA GGAAAGTGCC ACAATTGTCA 1620
80 CATGACCGGT ACTGGAAGAA ACTCTCCCAT CCAACATCAC CCAGTGGATG GAACATCCTG 1680
TAACTTTTCA CTGCACTTGG CATTATTTTT ATAAGCTGAA TGTGATAATA AGGACACTAT 1740
GGAAATGTCT GGATCATTCC GTTTGTGCGT ACTTTGAGAT TTGGTTTGGG ATGTCATTGT 1800
TTTCACAGCA CTTTTTTATC CTAATGTAAA TGCTTTATTT ATTTATTTGG GCTACATTGT 1860
AAGATCCATC TACACAGTCG TTGTCCGACT TCACTTGATA CTATATGATA TGAACCTTTT 1920 TTGGGTGGGG GGTGCGGGGC AGTTCACTCT GTCTCCCAGG CTGGAGTGCA ATGGTGCAAT 1980
CTTGGCTCAC TATAGCCTTG ACCTCTCAGC CTCAAGCGAT TCTCCCACCT CAGCCATCCA 2040
AATAGCTGCG ACCACAGGTG TGCACCACCA CGCCCGGCTA ATTTTTTGTA TTTTGTCTAG 2100
ATATAGGGGC TCTCTATGTT GCTCAGGGTG GTCTCGAATT CCTGGACTCA AGCAGTCTGC 2160 CCACCTCAGA CTCCCAAAGC GGTGGAATTA GAGGCGTGAG CCCCCATGCT TGGCCTTACC 2220
TTTCTACTTT TATAATTCTG TATGTTATTA TTTTATGAAC ATGAAGAAAC TTTAGTAAAT 2280
GTACTTGTTT ACATAGTTAT GTGAATAGAT TAGATAAACA TAAAAGGAGG AGACATACAA 2340
TGGGGGAAGA AGAAGAAGTC CCCTGTAAGA TGTCACTGTC TGGGTTCCAG CCCTCCCTCA 2400
GATGTACTTT GGCTTCAATG ATTGGCAACT TCTACAGGGG CCAGTCTTTT GAACTGGACA 2460 ACCTTACAAG TATATGAGTA TTATTTATAG GTAGTTGTTT ACATATGAGT CGGGACCAAA 2520
GAGAACTGGA TCCACGTGAA GTCCTGTGTG TGGCTGGTCC CTACCTGGGC AGTCTCATTT 2580
GCACCCATAG CCCCCATCTA TGGACAGGCT GGGACAGAGG CAGATGGGTT AGATCACACA 2640
TAACAATAGG GTCTATGTCA TATCCCAAGT GAACTTGAGC CCTGTTTGGG CTCAGGAGAT 2700
AGAAGACAAA ATCTGTCTCC CACGTCTGCC ATGGCATCAA GGGGGAAGAG TAGATGGTGC 2760 TTGAGAATGG TGTGAAATGG TTGCCATCTC AGGAGTAGAT GGCCCGGCTC ACTTCTCCTT 2820
ATCTGTCACC CTGAGCCCAT GAGCTGCCTT TTAGGGTACA GATTGCCTAC TTGAGGACCT 2880
TGGCCGCTCT GTAAGCATCT GACTCATCTC AGAAATGTCA ATTCTTAAAC ACTGTGGCAA 2940
CAGGACCTAG AATGGCTGAC GCATTAAGGT TTTCTTCTTG TGTCCTGTTC TATTATTGTT 3000
TTAAGACCTC AGTAACCATT TCAGCCTCTT TCCAGCAAAC CCTTCTCCAT AGTATTTCAG 3060 TCATCCAAGG ATCATTTATG CAGCTAGTCA TTCCAGGAGT TTTTGGTCTT TTCTGTCTCA 3120
AGGCATTGTG TGTTTTGTTC CGGGACTGGT TTGGGTGGGA CAAAGTTAGA ATTGCCTGAA 3180
GATCACACAT TCAGACTGTT GTGTCTGTGG AGTTTTAGGA GTGGGGGGTG ACCTTTCTGG 3240
TCTTTGCACT TCCATCCTCT CCCACTTCCA TCTGGCATCC CACGCGTTGT CCCCTGCACT 3300
TCTGGAAGGC ACAGGGTGCT GCTGCCTCCT GGTCTTTGCC TTTGCTGGGC CTTCTGTGCA 3360 GGACGCTCAG CCTCAGGGCT CAGAAGGTGC CAGTCCGGTC CCAGGTCCCT TGTCCCTTCC 3420
ACAGAGGCCT TCCTAGAAGA TGCATCTAGA GTGTCAGCCT TATCAGTGTT TAAGATTTGT 3480
CTTTTATTTT TAATTTTTTT GAGACAGAAT CTCACTCTCT CGCCCAGGCT GGAGTGCAAC 3540
GGTACGATCT TGGCTCAGTG CAACCTCCGC CTCCTGGGTT CAAGCGATTC TCGTGCCTCA 3600
GCCTCCGGAG TAGCTGGGAT TGCAGGCACC CGCCACCACG CCTGGCTAAT TTTTGTATTT 3660 TTAGTAGAGA CGGGGTTTCA CCATGTTGGT CAGGCTGGTC TCGAACTCCT GACCTCAGGT 3720
GATCCACCTT GGCCTCCGAA AGTGCTGGGA TTACAGGCGT GAGCCACCAG CCAGGCCAAG 3780
CTATTCTTTT AAAGTAAGCT TCCTGACGAC ATGAAATAAT TGGGGGTTTT GTTGTTTAGT 3840
TACATTAGGC TTTGCTATAT CCCCAGGCCA AATAGCATGT GACACACCAC AGCCATAGTA 3900
TAGTGTGTCA CTCGTGGTTG GTGTCCTTTC ATGCTTCTGC CCTGTCAAAG GTCCCTATTT 3960 GAAATGTGTT ATAATACAAA CAAGGAAGCA CATTGTGTAC AAAATACTTA TGTATTTATG 4020
AATCCATGAC CAAATTAAAT ATGAAACCTT ATATAAAAAA AAAAAAAAAA AAA 4073
Seq ID NO . 113 DNA Sequence Nucleic Acid Accession tt : NM_0020ll 2 Coding sequence : 157 . .2565
1 11 21 31 41 51
I I I I I I
CCGAGGAGCG CTCGGGCTGT CTGCGGACCC TGCCGCGTGC AGGGGTCGCG GCCGCCTGCA 60
GCTGGGAGTG AGGCGGCGGA GGAGCCAGGT GAGGAGGAGC CAGGAAGGCA GTTGGTGGGA 120 AGTCCAGCTT GGGTCCCTGA GAGCTGTGAG AAGGAGATGC GGCTGCTGCT GGCCCTGTTG 180
GGGGTCCTGC TGAGTGTGCC TGGGCCTCCA GTCTTGTCCC TGGAGGCCTC TGAGGAAGTG 240
GAGCTTGAGC CCTGCCTGGC TCCCAGCCTG GAGCAGCAAG AGCAGGAGCT GACAGTAGCC 300
CTTGGGCAGC CTGTGCGGCT GTGCTGTGGG CGGGCTGAGC GTGGTGGCCA CTGGTACAAG 360
GAGGGCAGTC GCCTGGCACC TGCTGGCCGT GTACGGGGCT GGAGGGGCCG CCTAGAGATT 420 GCCAGCTTCC TACCTGAGGA TGCTGGCCGC TACCTCTGCC TGGCACGAGG CTCCATGATC 480
GTCCTGCAGA ATCTCACCTT GATTACAGCT GACTCCTTGA CCTCCAGCAA CGATGATGAG 540
GACCCCAAGT CCCATAGGGA CCTCTCGAAT AGGCACAGTT ACCCCCAGCA AGCACCCTAC 600
TGGACACACC CCCAGCGCAT GGAGAAGAAA CTGCATGCAG TACCTGCGGG GAACACCGTC 660
AAGTTCCGCT GTCCAGCTGC AGGCAACCCC ACGCCCACCA TCCGCTGGCT TAAGGATGGA 720 CAGGCCTTTC ATGGGGAGAA CCGCATTGGA GGCATTCCCC TGCGCCATCA GCACTGGAGT 780
CTCGTGATGG AGAGCGTGGT GCCCTCGGAC CGCGGCACAT ACACCTGCCT GGTAGAGAAC 840
GCTGTGGGCA GCATCCGCTA TAACTACCTG CTAGATGTGC TGGAGCGGTC CCCGCACCGG 900
CCCATCCTGC ACCCCGGGCT CCCGGCCAAC ACCACAGCCG TGGTGGGCAG CGACGTGGAG 960
CTGCTGTGCA AGGTGTACAG CGATGCCCAG CCCCACATCC AGTGGCTGAA GCACATCGTC 1020 ATCAACGGCA GCAGCTTCGG AGCCGACGGT TTCCCCTATG TGCAAGTCCT AAAGACTGCA 1080
GACATCAATA GCTCAGAGGT GGAGGTCCTG TACCTGCGGA ACGTGTCAGC CGAGGACGCA 1140
GGCGAGTACA CCTGCCTCGC AGGCAATTCC ATCGGCCTCT CCTACCAGTC TGCCTGGCTC 1200
ACGCTGCTGC CAGAGGAGGA CCCCACATCC ACCGCAGCAG CGCCCGAGGC CAGGTATACG 1260
GACATCATCC TGTACGCGTC GGGCTCCCTG GCCTTGGCTG TGCTCCTGCT GCTGGCCGGG 1320 CTGTATCGAG GGCAGGCGCT CCACGGCCGG CACCCCCGCC CGCCCGCCAC TGTGCAGAAG 1380
CTCTCCCGCT TCCCTCTGGC CCGACAGTTC TCCCTGGAGT CAGGCTCTTC CGGCAAGTCA 1440
AGCTCATCCC TGGTACGAGG CGTGCGTCTC TCCTCCAGCG GCCCCGCCTT GCTCGCCGGC 1500
CTCGTGAGTC TAGATCTACC TCTCGACCCA CTATGGGAGT TCCCCCGCCA CAGGCTGGTG 1560
CTTGGGAAGC CCCTAGCCGA GGGCTGCTTT GGCCAGGTAG TACGTGCAGA GGCCTTTGGC 1620 ATGGACCCTG CCCGGCCTGA CCAAGCCAGC ACTGTGGCCG TCAAGATGCT CAAAGACAAC 1680
GCCTCTGACA AGGACCTGGC CGACCTGGTC TCGGAGATGG AGGTGATGAA GCTGATCCCC 1740
CGACACAAGA ACATCATCAA CCTGCTTGGT GTCTGCACCC AGGAAGGGCC CCTGTACGTG 1800
ATCGTGGAGT GCGCCGCCAA GGGAAACCTG CGGGAGTTCC TGCGGGCCCG GCGCCCCCCA 1860
GGCCCCGACC TCAGCCCCGA CGGTCCTCCC AGCAGTGAGG GGCCGCTCTC CTTCCCAGTC 1920 CTGGTCTCCT GCGCCTACCA GGTGGCCCGA GGCATGCAGT ATCTGGAGTC CCGGAAGTGT 1980
ATCCACCGGG ACCTGGCTGC CCGCAATGTG CTGGTGACTG AGGACAATGT GATGAAGATT 2040
GCTGACTTTG GGCTGGCCCG CGGCGTCCAC CACATTGACT ACTATAAGAA AACCAGCAAC 2100
GGCCGCCTGC CTGTGAAGTG GATGGCGCCC GAGGCCTTGT TTGACCGGGT GTACACACAC 2160
CAGAGTGACG TGTGGTCTTT TGGGATCCTG CTATGCGAGA TCTTCACCCT CGGGGGCTCC 2220 CCGTATCCTG GCATCCCGGT GGAGGAGCTG TTCTCGCTGC TGCGGGAGGG ACATCGGATG 2280
GACCGACCCC CACACTGCCC CCCAGAGCTG TACGGGCTGA TGCGTGAGTG CTGGCACGCA 2340
GCGCCCTCCC AGAGGCCTAC CTTCAAGCAG CTGGTGGAGG CGCTGGACAA GGTCCTGCTG 2400
GCCGTCTCTG AGGAGTACCT CGACCTCCGC CTGACCTTCG GACCCTATTC CCCCTCTCCT 2460
GGGGACGCCA GCAGCACCTG CTCCTCCAGC GATTCTGTCT TCAGCCACGA CCCCCTGCCA 2520 TTGGGATCCA GCTCCTTCCC CTTCCCGTCT GGGGTGCAGA CATGAGCAAG GCTCAAGGCT 2580
GTGCAGGCAC ATAGGCTGGT GGCCTTGGGC CTTGGGGCTC AGCCACAGCC TGACACAGTG 2640
CTCGACCTTG ATAGCATGGG GCCCCTGGCC CAGAGTTGCT GTGCCGTGTC CAAGGGCCGT 2700
GCCCTTGCCC TTGGAGCTGC CGTGCCTGTG TCCTGATGGC CCAAATGTCA GGGTTCTGCT 2 60
CGGCTTCTTG GACCATGGCG CTTAGTCCCC ATCCCGGGTT TGGCTGAGCC TGGCTGGAGA 2820
GCTGCTATGC TAAACCTCCT GCCTCCCAAT ACCAGCAGGA GGTTCTGGGC CTCTGAACCC 2880
CCTTTCCCCA CACCTCCCCC TGCTGCTGCT GCCCCAGCGT CTTGACGGGA GCATTGCCCC 2940
CTGAGCCCAG AGAAGCTGGA AGCCTGCCGA AAACAGGAGC AAATGGCGTT TTATAAATTA 3000
TTTTTTTGAA ATAAA 3015
Seq ID NO 114 DNA Sequence
Nucleic Acid Accession If NM_022963 1
Coding sequence 157 2445
1 11 21 31 41 51 i i i i i i
CCGAGGAGCG CTCGGGCTGT CTGCGGACCC TGCCGCGTGC AGGGGTCGCG GCCGCCTGCA 60
GCTGGGAGTG AGGCGGCGGA GGAGCCAGGT GAGGAGGAGC CAGGAAGGCA GTTGGTGGGA 120
AGTCCAGCTT GGGTCCCTGA GAGCTGTGAG AAGGAGATGC GGCTGCTGCT GGCCCTGTTG 180
GGGGTCCTGC TGAGTGTGCC TGGGCCTCCA GTCTTGTCCC TGGAGGCCTC TGAGGAAGTG 240
GAGCTTGAGC CCTGCCTGGC TCCCAGCCTG GAGCAGCAAG AGCAGCAGCT GACAGTAGCC 300
CTTGGGCAGC CTGTGCGGCT GTGCTGTGGG CGCCCTGAGC GTGGTGGCCA CTGGTACAAG 360
GAGGGCAGTC GCCTGGCACC TGCTGCCCGT GTACGGGGCT GGAGGGGCCG CCTAGAGATT 420
GCCAGCTTCC TACCTGAGGA TGCTGGCCGC TACCTCTGCC TGGCACGAGG CTCCATGATC 480
GTCCTGCAGA ATCTCACCTT GATTACAGCT GACTCCTTGA CCTCCAGCAA CGATGATGAG 540
GACCCCAAGT CCCATAGGGA CCTCTCGAAT AGGCACAGTT ACCCCCAGCA AGCACCCTAC 600
TGGACACACC CCCAGCGCAT GGAGAAGAAA CTGCATGCAG TACCTGCGGG GAACACCGTC 660
AAGTTCCGCT GTCCAGCTGC AGGCAACCCC ACGCCCACCA TCCGCTGGCT TAAGGATGGA 720
CAGGCCTTTC ATGGGGAGAA CCGCATTGGA GGCATTCGGC TGCGCCATCA GCACTGGAGT 780
CTCGTGATGG AGAGCGTGGT GCCCTCG AC CGCGGCACAT ACACCTGCCT GGTAGAGAAC 840
GCTGTGGGCA GCATCCGCTA TAACTACCTG CTAGATGTGC TGGAGCGGTC CCCGCACCGG 900
CCCATCCTGC AGGCCGGGCT CCCGGCCAAC ACCACAGCCG TGGTGGGCAG CGACGTGGAG 960
CTGCTGTGCA AGGTGTACAG CGATGCCCAG CCCCACATCC AGTGGCTGAA GCACATCGTC 1020
ATCAACGCCA GCAGCTTCGC AGCCGACGGT TTCCCCTATG TGCAAGTCCT AAAGACTGCA 1080
GACATCAATA GCTCAGAGGT GGAGGTCCTG TACCTGCGGA ACGTGTCAGC CGAGGACGCA 1140
GGCGAGTACA CCTGCCTCGC AGGCAATTCC ATCGGCCTCT CCTACCAGTC TGCCTGGCTC 1200
ACGGTGCTGC CAGGTACTGG GCGCATCCCC CACCTCACAT GTGACAGCCT GACTCCAGCA 1260
GGCAGAACCA AGTCTCCCAC TTTGCAGTTC TCCCTGGAGT CAGGCTCTTC CGGCAAGTCA 1320
AGCTCATCCC TGGTACGAGG CGTGCGTCTC TCCTCCAGCG GCCCCGCCTT GCTCGCCGGC 1380
CTCGTGAGTC TAGATCTACC TCTCGACCCA CTATGGGAGT TCCCCCGGGA CACCCTGGTG 1440
CTTGGGAAGC CCCTAGGCGA GGGCTGCTTT GGCCAGGTAG TACGTGCAGA GGCCTTTGGC 1500
ATGGACCCTG CCCGGCCTGA CCAAGCCAGC ACTGTGGCCG TCAAGATGCT CAAAGACAAC 1560
GCCTCTGACA AGGACCTGGC CGACCTGCTC TCGGAGATGG AGGTGATGAA GCTGATCGGC 1620
CGACACAAGA ACATCATCAA CCTGCTTGGT GTCTGCACCC AGGAAGGGCC CCTGTACGTG 1680
ATCGTGGAGT GCGCCGCCAA GGGAAACCTG CGGGAGTTCC TGCGGGCCCG GCGCCCCCCA 1740
GGCCCCGACC TCAGCCCCGA CGGTCCTCGG AGCAGTGAGG GGCCGCTCTC CTTCCCAGTC 1800
CTGGTCTCCT GCGCCTACCA GGTGGCCCGA GGCATGCAGT ATCTGGAGTC CCGGAAGTGT 1860
ATCCACCGGG ACCTGGCTGC CCGCAATGTG CTGGTGACTG AGGACAATGT GATGAAGATT 1920
GCTGACTTTG GGCTGGCCCG CGGCGTCCAC CACATTGACT ACTATAAGAA AACCAGCAAC 1980
GGCCGCCTGC CTGTGAAGTG GATGGCGCCC GAGGCCTTGT TTGACCGGGT GTACACACAC 2040
CAGAGTGACG TGTGGTCTTT TGGGATCCTG CTATGGGAGA TCTTCACCCT CGGGGGCTCC 2100
CCGTATCCTG GCATCCCGGT GGAGGAGCTG TTCTCGCTGC TGCGGGAGGG ACATCGGATG 2160
GACCGACCCC CACACTGCCC CCCAGAGCTG TACGGGCTGA TGCGTGAGTG CTGGCACGCA 2220
GCGCCCTCCC AGAGGCCTAC CTTCAAGCAG CTCCTGGAGG CGCTGGACAA GGTCCTGCTG 2280
GCCGTCTCTG AGGAGTACCT CGACCTCCGC CTGACCTTCG GACCCTATTC CCCCTCTGGT 2340
GGGGACGCCA GCAGCACCTG CTCCTCCAGC GATTCTGTCT TCAGCCACGA CCCCCTGCCA 2400
TTGGGATCCA GCTCCTTCCC CTTCGGGTCT GGGGTGCAGA CATGAGCAAG GCTCAAGGCT 2460
GTGCAGGCAC ATAGGCTGGT GGCCTTGGGC CTTGGGGCTC AGCCACAGCC TGACACAGTG 2520
CTCGACCTTG ATAGCATGGG GCCCCTGGCC CAGAGTTGCT GTGCCGTGTC CAAGGGCCGT 2580
GCCCTTGCCC TTGGAGCTGC CGTGCCTGTG TCCTGATGGC CCAAATGTCA GGGTTCTGCT 2640
CGGCTTCTTG GACCATGGCG CTTAGTCCCC ATCCCGGGTT TGGCTGAGCC TGGCTGGAGA 2700
GCTGCTATGC TAAACCTCCT GCCTCCCAAT ACCAGCAGGA GGTTCTGGGC CTCTGAACCC 2760
CCTTTCCCCA CACCTCCCCC TGCTGCTGCT GCCCCAGCGT CTTGACGGGA GCATTGGCCC 2820
CTGAGCCCAG AGAAGCTGGA AGCCTGCCGA AAACAGGAGC AAATGGCGTT TTATAAATTA 2880
TTTTTTTGAA ATAAA 2895
Seq ID NO 15 DNA Sequence
Nucleic Acid Accession ft NM_002845 2
Coding sequence 1 4359
1 11 21 31 41 51 i i i i i i
ATGAGGGGAC TTGGGACTTG CCTGGCGACT TTGGCCCCAC TTTTGCTAAC TGCGGCGGGC 60
GAGACGTTCT CACCTGGCTG CCTCTTTGAT GAGCCGTATA GCACATGTGG ATATAGTCAA 120
TCTGAAGGTG ATGACTTCAA TTGGGAGCAA GTGAACACCT TGACTAAACC GACTTCTGAT 180
CCATGGATGC CATCAGGTTC TCTCATGCTG GTGAATGCCT CTGGGAGACC TGAGGGGCAG 240
AGAGCCCACC TGCTCTTACC CCAACTTAAG GAAAATGACA CCCACTGCAT CGATTTTCAC 300
TATTTTGTGT CCAGCAAGAG TAATTCTCCT CCGGGGTTAC TCAATGTCTA CGTGAAGGTC 360
AATAACGGGC CACTGGGGAA TCCTATCTCC AATATATCTG GAGACCCAAC ACGTACATGG 420
AACAGGGCAG AACTGGCCAT TAGTACTTTC TGGCCTAACT TTTATCAGGT GATTTTTGAA 480
GTGATAACTT CTGGACATCA AGGCTATCTC GCTATCGATG AGGTGAAGGT GTTAGGACAT 540
CCATGTACCA GGACTCCTCA CTTCCTGCGG ATTCAGAATG TGGAAGTTAA TGCTGGCCAG 600
TTTGCTACCT TCCAGTGCAG TGCCATCGGC AGGACCGTGG CAGGAGACAG GCTCTGGTTA 660
CAGGGCATTG ATGTGCGAGA TGCTCCTCTG AAGGAAATCA AGGTGACCAG CTCCCGACGC 720
TTCATTGCTT CATTTAATGT TGTGAATACC ACCAAACGAG ATGCTCCAAA GTACCGCTGC 780
ATGATTCGCA CTGAAGGAGG TGTTGGAATA TCAAACTATG CAGAGTTGGT AGTTAAAGAA 840 CCACCCGTTC CTATTGCCCC ACCTCAGCTC GCCTCTGTAG GAGCCACCTA CCTGTGGATA 900
CAGCTCAACG CCAACTCCAT CAATGGGGAT GGGCCCATTG TGGCCCGAGA GGTGGAGTAC 960
TGCACGGCCA GTGGGAGCTG GAATGACCGG CAGCCAGTCG ATTCCACGAG CTATAAAATT 1020
GGACACCTTG ACCCAGATAC AGAATATGAG ATTAGTGTGC TCCTGACCAG GCCAGGGGAG 1080
GGTGGCACTG GCTCTCCTGG TCCAGCTCTC AGGACAAGAA CAAAGTGTGC TGATCCCATG 1140
CGAGGCCCAA GAAAACTAGA AGTAGTGGAG GTCAAATCTC GGCAAATCAC TATCCGCTGG 1200
GAGCCATTTG GATATAATGT AACTCGTTGC CACAGTTATA ATCTCACTGT CCACTACTGT 1260
TACCAAGTTG GAGGACAAGA ACAAGTGCGA GAAGAAGTAA GCTGGGATAC AGAAAATTCA 1320
CACCCTCAAC ACACGATCAC TAACCTGTCA CCATACACCA ATGTCAGTGT GAAACTGATC 1380
CTCATGAACC CAGAGGGCCG GAAGGAAAGC CAAGAACTCA TAGTGCAGAC AGATGAAGAC 1440
CTCCCAGGTG CTGTTCCCAC TGAATCCATA CAAGGAAGTA CCTTTGAAGA GAAGATATTT 1500
CTTCAGTGGA GAGAACCAAC TCAAACATAT GGTGTAATCA CTTTATATGA GATCACCTAC 1560
AAAGCAGTCA GTTCCTTTGA CCCAGAAATA GATTTATCCA ATCAGAGTGG AAGAGTTTCA 1620
AAGCTGGGAA ATGAAACCCA TTTTCTGTTT TTTGGACTGT ATCCGGGGAC CACATACTCC 1680
TTTACCATCC GAGCTAGCAC AGCTAAGGGT TTTGGGCCTC CAGCAACAAA CCAGTTCACC 1740
ACCAAAATAT CAGCACCCTC TATGCCAGCT TATGAACTTG AGACACCTTT GAATCAAACT 1800
GACAATACCG TGACAGTCAT GCTGAAACCT GCCCACAGCA GAGGAGCACC TGTCAGTGTC 1860
TATCAAATAG TTGTTGAGGA AGAACGTCCT CGAAGAACTA AAAAGACGAC AGAAATCTTA 1920
AAGTGCTACC CAGTGCCAAT TCACTTCCAG AATGCTTCTC TGCTGAACTC ACAGTACTAC 1980
TTTGCTGCAG AATTTCCTGC AGACAGCCTC CAAGCTGCGC AGCCTTTTAC AATTGGTGAT 2040
AATAAGACAT ATAATGGATA CTGGAACACT CCCCTTCTCC CCTATAAAAG CTACAGAATT 2100
TATTTCCAAG CTGCTAGTAG AGCCAATGGG GAAACCAAAA TAGACTGTGT CCAAGTGGCC 2160
ACAAAAGGAG CTGCCACTCC GAAACCAGTC CCAGAACCCG AGAAACAGAC AGACCATACA 2220
GTTAAAATTG CTGGAGTCAT CGCGGGCATC TTGCTGTTCG TGATTATATT TCTTGGAGTT 2280
GTGTTGGTAA TGAAGAAAAG GAAACTGGCC AAGAAGCGGA AAGAGACCAT GAGCAGCACC 2340
CGACAGGAGA TGACTGTGAT GGTGAACTCA ATGGACAAGA GCTATGCTGA GCAGGGCACA 2400
AACTGCGACG AGGCTTTCTC ATTCATGGAC ACGCACAATC TGAATGGGAG ATCTGTGTCT 2460
TCACCATCGT CCTTCACAAT GAAAACAAAT ACACTGAGCA CATCCCTGCC TAATTCCTAT 2520
TACCCAGATG AAACCCACAC AATGGCCAGC GATACCAGCA GCCTGGTGCA GTCCCATACT 2580
TACAAGAAGC GAGAGCCGGC CGACGTGCCC TATCAGACTG GGCAGCTCCA CCCCGCCATC 2640
CGGGTGGCAG ACCTCCTTCA GCACATCACA CAGATGAAGT GTGCGGAGGG CTACGGCTTC 2700
AAGGAGGAAT ACGAGAGCTT CTTTGAAGGG CAGTCTGCAC CATGGGACTC GGCTAAGAAA 2760
GATGAGAACA GAATGAAGAA CAGATACGGG AATATCATTG CATACGATCA TTCCCGAGTG 2820
AGGCTGCAGA CAATAGAAGG AGACACAAAC TCAGACTATA TCAATGGCAA TTATATCGAT 2880
GGTTATCATC GACCCAATCA TTACATTGCT ACCCAAGGGC CAATGCAGGA AACCATCTAT 2940
GACTTCTGGA GGATGGTGTG GCACGAAAAC ACTGCAAGTA TCATCATCCT GACCAATCTT 3000
GTGGAAGTGG GAAGGGTCAA ATGCTGCAAA TACTGGCCAG ATGACACAGA GATATATAAA 3060
GACATTAAAG TTACCCTAAT AGAAACAGAA CTACTGGCAG AATATGTGAT AAGAACATTT 3120
GCTGTTGAAA AGAGAGGTGT GCATGAAATC CGAGAGATCA GACAGTTTCA CTTCACTGGC 3180
TGGCCGGATC ATGGGGTCCC CTACCATGCC ACCGGCCTGC TCCGATTCGT GCGGCAAGTC 3240
AAGTCCAAGA GCCCGCCCAG TGCAGCCCCA CTGGTGGTGC ACTGCAGTGC TGGTGCAGGG 3300
AGGACTGGCT GTTTCATCGT CATTGATATC ATGTTGGACA TCCCCGAAAG GGAAGGGGTC 3360
GTAGACATCT ACAACTGCGT CAGGGAGCTG CGCTCACGGA GGGTGAACAT GGTGCAAACA 3420
GAGGAGCAGT ATGTGTTTAT CCACGATGCG ATCCTGGAAG CCTGTCTTTG TGGGGACACC 3480
TCTGTGCCTG CTTCCCAAGT TAGGTCTCTG TATTATGACA TGAACAAACT GGATCCACAG 3540
ACAAACTCAA GCCAGATTAA AGAGGAATTC CCCACGCTAA ACATGGTGAC ACCAACGCTG 3600
CGAGTAGAGG ACTGCAGCAT CGCACTGTTG CCCCGGAACC ATGAGAAAAA CCGGTGCATG 3660
GACATCCTGC CCCCAGACCG CTGCCTGCCC TTCCTCATCA CCATCGATGG GGAGAGCAGC 3720
AACTACATCA ATGCTGCCCT CATGGACAGC TATAAACAGC CTTCAGCTTT TATAGTCACC 3780
CAGCATCCTT TGCCAAACAC AGTGAAAGAC TTTTGGAGAC TGGTCCTGGA TTATCACTGC 3840
ACATCCGTAG TTATGCTAAA TGATGTGGAT CCTGCCCAGT TGTGTCCACA GTACTGGCCA 3900
GAAAACGGAG TACACAGACA CGGCCCCATC CAGGTGGAAT TTGTCTCTGC TGACCTCCAA 3960
GAGGACATCA TCAGCAGGAT ATTCCGCATT TACAATGCCG CCAGACCCCA AGATGGATAT 4020
CGGATGGTGC AGCAATTCCA GTTCCTGGGC TGGCCGATGT ACAGGGACAC ACCAGTGTCT 4080
AAGCGCTCCT TCTTGAAGCT CATTCGCCAG GTGGACAAGT GGCAAGAGGA ATACAATGGC 4140
GGGGAAGGCC CGACCGTTGT GCACTGCTTG AACGGGGGAG GCCGCAGTGG GACGTTCTGC 4200
GCCATCAGCA TCGTATGTGA GATGCTCCGG CACCAGAGAA CCGTGGATGT CTTTCACGCT 4260
GTGAAGACAC TGAGGAACAA CAAGCCCAAC ATGGTCGACC TCCTGGATCA GTACAAGTTC 4320
TGCTACGAGG TGGCCCTGGA ATACTTGAAT TCTGGCTGAT GGTGTAAACA GCTCTGCAAA 4380
CAATCCCTTT CATACCACAA AGCCAAGACG TTCCATGGTA TTTGTGCAAA AGAGATGAAG 4440
ACTTCTCAAT ATGCTTATTT TGCTTTGCAT AATTGGCTCT TTTTAAGAGC CCAAGAAAGT 4500
GTTTCTAAAA TTGCTTGCAC TGCCCAATCC CAGTAATGCT GCTGCCTGAC AGAAACACAC 4560
ACACAGCCAC AGTTGCCAAA TCCCGTACTC CTTGCCACCG GCTTTCTAGA GCAGCGTAGA 4620
CAGCTGGTAA ACTGAAGAGC ACAACTATAT TCTTATGAAG GAATTTGTAC CTTTGGGGTA 4680
TTATTTTGTG GCCCGTGACC CTCGTTATTG TTACAGCTGA GTGTATGTTT TTGTTCTGTG 4740
GAGAATGCTA TCTGGCATTA TGGTAATATA TTATTTTAGG TAATATTTGT ACTTTAACAT 4800
GTTGCATAAT ATATGCTTAT GTAGCTTTCC AGGACTAACA GATAAATGTG TAATGAACAA 4860
AGATATGTTG TATGAGTCGT CGTTTCTGTC AGATTTGTAT TGTTTCCAAG GGAAAAGCTT 4920
GGGGGAGGAC TCAGTTCACA AAATGCAAAA CTCAACGATC AGATTCACGG ACCCAGAGCT 4980
TTTCCATGTG TTTATATTGT AAATATTTTT GATTTCATCA AATTATTTAT TCATTAAAAG 5040
AAATTTTTGT GAAAAAAAAA AAAAA 5065
Seq ID NO : 116 DNA Sequence
Nucleic Acid Accession It : NM_016551 . 1
Coding sequence - 38 . . 1750
1 11 21 31 41 51 l l l l 1 1
CCAGCCCTGG CGTGGGCCCA GCCCGGCCCA GGCAGCAATG GGGTTCCTGC AGCTGCTCCT 60 CGTAGCGGTG CTGGCATCCG AACACCGGGT GGCTGGTGCA GCCGAGGTCT TCGGGAATTC 120 CAGCGAGGGT CTTATTGAAT TTTCTGTGGG GAAATTTAGA TACTTCGAGC TCAATAGGCC 180 CTTTCCAGAG GAAGCTATTT TGCATGATAT TTCAAGCAAT GTGACTTTTC TTATTTTCCA 240 AATACACTCA CAGTATCAGA ATACAACTGT TTCCTTTTCT CCGACTCTCC TTTCCAATTC 300 CTCGGAAACA GGCACTGCCA GTGGACTGGT TTTCATCCTT AGACCAGAGC AGAGTACATG 360 CACTTGGTAC TTGGGGACTT CAGGCATACA GCCTGTCCAG AATATGGCTA TCCTACTCTC 420 CTACTCAGAA AGAGATCCTG TCCCTGGAGG CTGTAATTTG GAGTTCGATT TAGATATTGA 480
TCCCAACATT TACTTGCAGT ATAATTTCTT TGAAACGACT ATCAAGTTTG CCCCAGCAAA 540
CCTAGGCTAT GCGAGAGGCG TAGATCCCCC ACCATGTGAC GCTGGGACAG ACCAGGACTC 600
CAGGTGGAGG TTGCAGTATG ATGTCTATCA GTATTTTCTG CCTGAGAATG ACCTCACTGA 660
GGAGATGTTG CTGAAGCATC TGCAGAGGAT GGTCAGTGTG CCCCAGCTGA AGGCCAGTGC 720
TCTCAAGGTG GTTACCCTAA CAGCTAATGA TAAGACAAGT GTTTCCTTCT CCTCCCTCCC 780
GGGACAAGGT GTCATATACA ATGTCATTGT TTGGGACCCG TTTCTAAATA CATCTGCTGC 840
CTACATTCCT GCTCACACAT ACGCTTGCAG CTTTGAGGCA GGAGAGGGTA GTTGTGCTTC 900
CCTAGGAAGA GTGTCTTCCA AAGTGTTCTT CACTCTTTTT GCCCTGCTTG GTTTCTTCAT 960
TTGTTTCTTT GGACACAGAT TCTGGAAAAC AGAATTATTC TTCATAGGCT TTATCATCAT 1020
GGGATTCTTC TTTTATATAC TGATTACAAG ACTGACACCT ATCAAGTATG ATGTGAATCT 1080
GATTCTGACA GCTGTCACTG GAAGCGTCGG TGGAATGTTC TTGGTAGCTG TGTGGTGGCG 1140
ATTTGGAATC CTCTCGATCT GCATGCTCTG TGTTGGACTA GTGCTGGGGT TCCTCATCTC 1200
GTCAGTGACT TTCTTTACTC CACTGGGAAA CCTAAAGATT TTTCATGATG ATGGTGTATT 1260
CTGGGTCACT TTCTCTTGCA TAGCTATCCT CATTCCAGTA GTTTTCATGG GCTGCC AAG 1320
AATACTGAAC ATACTGACTT GTGGAGTCAT TGGCTCCTAT TCGGTGGTTT TAGCCATTGA 1380
CAGTTACTGG TCCACAAGCC TTTCCTACAT CACTTTGAAC GTACTCAAGA GAGCGCTCAA 1440
CAAGGATTTC CACAGAGCTT TCACAAATGT GCCTTTTCAA ACTAATGACT TCATTATCCT 1500
GGCAGTATGG GGCATGCTGG CTGTAAGTGG AATTACGTTA CAGATTCGAA GAGAGAGAGG 1560
ACGACCGTTC TTCCCTCCCC ACCCATACAA GTTATGGAAG CAAGAGAGAG AGCGCCGAGT 1620
GACAAACATT CTGGACCCTA GCTACCACAT TCCTCCATTG AGAGAGAGGC TCTATGGCCG 1680
ATTAACCCAG ATTAAAGGGC TCTTCCAGAA GGAGCAGCCA GCTGGAGAGA GAACGCCTTT 1740
GCTTCTGTAG ATGCCCAGGG GCTTGGTCAG TGTGCCTCAG CTTTGGAGTT CATGCCTGGA 1800
GTGGTTCAAC AGTCTCTGGT GCAAGTCTAA TAAGAGATCA GGCATATATA TCTGTTCTTT 1860
GCATAATATT ATGGTGCCCT TATTGATATA TGGTAAGGGT GTACTAGGGG ATTAGGATGA 1920
TTGTAAGAGA ATGAGAAAGA TGACCAAAAG GTTGGTGGTA GGGAGGCTTT TTCTTATTTC 1980
CAAATACTTG AGAAATTACC TTTTGGTTTA CAAATCTATG ATCAACTTAT TCCATTAAAT 2040
AGATACATTA AAAAAATTAA AAACTGCAAA AAAAAAAAAA AAACTGGTGT TTCTTTTTAT 2100
AACCCCTTGA AACAAGTCTC TCACCTGAGC CTGTCTAAAC TTTCGGAGGG AGTTTATTAT 2160
TGAGTCTTTA TCTGTGACAG TATTTGGAGA TTTAGGGATT TGATACTTAG GCCTTTGAAT 2220
TTTAGAATAC AAAAAGAGAA GCAAGCCAGA CATGGTGGCT CACACCTGTA ATCCCAATAC 2280
TGGGAAGCCA AGGTGGGAGT ATCGCTTGAG CCCACCAGTT TGAGACCGAC ATGGGCAACA 2340
TGACAAGACC CCATCTCTAC AAAAAAAATT AAAAAATTAG CCAGGCATGG TGGCACATGC 2400
CTACTCCCAG CTCCCAAGGA GACTGAGATG GGAGGATCCC TGGAGCCCTG AAGATTGAGG 2460
CTACAGTGAG CCTTGATTGT GTCACTGCAC TCCAGCTTGG GTGACAGAGA CCCTGTCTCG 2520
AGAAATT 2527
Seq ID NO 117 DNA Sequence
Nucleic Acid Accession # NM_003820 1
Coding sequence 294 1145
1 11 21 31 l l l l CCTTCATACC GGCCCTTCCC CTCGGCTTTG CCTGGACAGC TCCTGCCTCC CGCAGGGCCC 60 ACCTGTGTCC CCCAGCGCCG CTCCACCCAG CAGGCCTGAG CCCCTCTCTG CTGCCAGACA 120 CCCCCTGCTG CCCACTCTCC TGCTGCTCGG GTTCTGAGGC ACAGCTTGTC ACACCGAGGC 180 GGATTCTCTT TCTCTTTCTC TTCTGGCCCA CAGCCGCAGC AATGGCGCTG AGTTCCTCTG 240 CTCCAGTTCA TCCTGCTAGC TGGGTTCCCG AGCTGCCGGT CTGAGCCTGA GGCATGGAGC 300 CTCCTGGAGA CTGGGGGCCT CCTCCCTGGA GATCCACCCC CAGAACCGAC GTCTTGAGGC 360 TGGTGCTGTA TCTCACCTTC CTGGGAGCCC CCTGCTACGC CCCAGCTCTG CCGTCCTGCA 420 ACCAGGACGA GTACCCAGTG GGCTCCGAGT GCTGCCCCAA GTGCAGTCCA GGTTATCGTG 480 TGAAGGAGGC CTGCGGGGAG CTGACGGGCA CAGTGTGTGA ACCCTGCCCT CCAG CACCT 540 ACATTGCCCA CCTCAATGGC CTAAGCAAGT GTCTGCAGTG CCAAATGTGT GACCCAGCCA 600 TGGGCCTGCG CGCGAGCCGG AACTGCTCCA GGACAGAGAA CGCCGTGTGT GGCTGCAGCC 660 CAGGCCACTT CTGCATCGTC CAGGACGGGG ACCACTGCGC CGCGTGCCGC GCTTACGCCA 720 CCTCCAGCCC GGGCCAGAGG GTGCAGAAGG GAGGCACCGA GAGTCAGGAC ACCCTGTGTC 780 AGAACTGCCC CCCGGGGACC TTCTCTCCCA ATGGGACCCT GGAGGAATGT CAGCACCAGA 840 CCAAGTGCAG CTCCCTGGTG ACGAAGGCCG GAGCTGGGAC CAGCAGCTCC CACTGGGTAT 900 GGTGGTTTCT CTCAGGGAGC CTCGTCATCG TCATTGTTTG CTCCACAGTT GGCCTAATCA 960 TATGTGTGAA AAGAAGAAAG CCAAGGGGTG ATGTAGTCAA GGTGATCGTC TCCGTCCAGC 1020 GGAAAAGACA GGAGGCAGAA GGTGAGGCCA CAGTCATTGA GGCCCTGCAG GCCCCTCCGG 1080 ACGTCACCAC GGTGGCCGTG GAGGAGACAA TACCCTCATT CACGGGGAGG AGCCCAAACC 1140 ACTGACCCAC AGACTCTGCA CCCCGACGCC AGAGATACCT GGAGCGACGG CTGCTGAAAG 1200 AGGCTGTCCA CCTGGCGAAA CCACCGGAGC CCGGAGGCTT GGGGGCTCCG CCCTGGGCTG 1260 GCTTCCGTCT CCTCCAGTGG AGGGAGAGGT GGGGCCCCTG CTGGGGTAGA GCTGGGGACG 1320 CCACGTGCCA TTCCCATGGG CCAGTGAGGG CCTCCGGCCT CTGTTCTGCT GTGGCCTGAG 1380 CTCCCCAGAG TCCTGAGGAG GAGCGCCAGT TGCCCCTCGC TCACAGACCA CACACCCAGC 1440 CCTCCTGGGC CAGCCCAGAG GGCCCTTCAG ACCCCAGCTG TCTGCGCGTC TGACTCTTGT 1500 GGCCTCAGCA GGACAGGCCC CCCGCACTGC CTCACAGCCA AGGCTGGACT GGGTTGGCTG 1560 CAGTGTGGTG TTTAGTGGAT ACCACATCGG AAGTGATTTT CTAAATTGGA TTTGAATTCC 1620 GGTCCTGTCT TCTATTTGTC ATGAAACAGT GTATTTGGGG AGATGCTGTG GGAGGATGTA 1680 AATATCTTGT TTCTCCTCAA AAAAAAAAAA AAAAAAAAAA AAAA 1724
Seq ID NO 118 DNA Sequence
Nucleic Acid Accession tt Eos sequence
Coding sequence 42 1070
1 11 21 31 l l l l CAGGCACCAC CAGGACCAGC TGATCATTCC AGCCCACAGC AATGGAGCCA CATGACTCCT 60 CCCACATGGA CTCTGAGTTC CGATACACTC TCTTCCCGAT TGTTTACAGC ATCATCTTTG 120 TGCTCGGGGT CATTGCTAAT GGCTACGTGC TGTGGGTCTT TGCCCGCCTG TACCCTTGCA 180 AGAAATTCAA TGAGATAAAG ATCTTCATGG TGAACCTCAC CATGGCGGAC ATGCTCTTCT 240 TGATCACCCT GCCACTTTGG ATTGTCTACT ACCAAAACCA GGGCAACTGG ATACTCCCCA 300 AATTCCTGTG CAACGTGGCT GGCTGCCTTT TCTTCATCAA CACCTACTGC TCTGTGGCCT 360 TCCTGGGCGT CATCACTTAT AACCGCTTCC AGGCAGTAAC TCGGCCCATC AAGACTGCTC 420 AGGCCAACAC CCGCAAGCGT GGCATCTCTT TGTCCTTGGT CATCTCCGTG GCCATTGTGG 480
GAGCTGCATC CTACTTCCTC ATCCTGGACT CCACCAACAC AGTGCCCGAC AGTGCTGGCT 540
CAGGCAACGT CACTCGCTGC TTTGAGCATT ACGAGAAGGG CAGCGTGCCA GTCCTCATCA 600
TCCACATCTT CATCGTGTTC AGCTTCTTCC TGGTCTTCCT CATCATCCTC TTCTGCAACC 660
TGGTCATCAT CCGTACCTTG CTCATGCAGC CGGTGCAGCA GCAGCGCAAC GCTGAAGTCA 720
AGCGCCGGGC GCTGTGGATG GTGTGCACGG TCTTCCCGGT GTTCATCATC TGCTTCGTGC 780
CCCACCACGT GGTGCAGCTG CCCTGGACCC TTGCTGAGCT GGGCTTCCAG GACAGCAAAT 840
TCCACCAGCC CATTAATGAT GCACATCAGG TCACCCTCTG CCTCCTTAGC ACCAACTGTG 900
TCTTAGACCC TGTTATCTAC TGTTTCCTCA CCAAGAAGTT CCGCAAGCAC CTCACCGAAA 960
AGTTCTACAG CATGCGCAGT AGCCGGAAAT GCTCCCGGGC CACCACGGAT ACGGTCACTG 1020
AAGTGGTTGT GCCATTCAAC CAGATCCCTG GCAATTCCCT CAAAAATTAG TCCCTGCTTC 1080
CAGGCCTGAA GTCTTCTCCT CCATGAACAT CATGCACTGA GCTCCGGGAA GAAGGGATAT 1140
CTACTGTGGT CTGGGCACCA CCTCTGTGGG CACTGGTGGG CCATTAGATT TGGAGGCTAC 1200
CTCACCTGGG CACCGATGAT GGCAGAGCCA GGCTGTTGGA AAATCCAGAA CTCAAATGAG 1260
CCCCTTCATC CGCCTGTGGG CGCATACTAC AGTAACTGTG ACTGATGACT TTATCCTGAG 1320
TCCCTTAATC TTATGGGGCC GGAAGGAATG TCAGGGCCAG GTGCAGACCT TGGGGGAAGA 1380
CTTTAAACCA CCTAGTTCTC CCCGATGGGG CATCCCTCTA AAGCTTTGGG GGAGTGGGCG 1440
CAGTCCCTCA CACCTGTAAT CCCAGCACTT TGGGAGGCCG AGGTGGGCAG ATCATGGGTC 1500
AAGAGATCGA GACCATCCTG GCCAACATTG TAAAACCCCA TCTCTACTAA AACATACAAA 1560
AATTAGCCGC GCATGGTGGC ACACGCCTGT AGTCCCAGCT ACTCAGGAGG CTGAGGCAGG 1620
AGAATCGCTT GAACCTGGGA GGCAGAGGTT GCAGTGAACC TAGATTGCAC CATTGCACTC 1680
TAGCCTGCCA ACAGAGCGAG ATTCCATCTC AAAAAAAAAA AAAAAAAAAA AAAAAAAGCT 1740
TTGGGCAACT ACTCTCAAGT GATAGAGGTA GACTGGGTTA GGAAAGGACA CTGCCCTCAC 1800
TGTATGGCAC TACCTTGGGG CAGACTTTTG AGCTAAGATG TTGCCATCCT CTCTCCACCC 1860
TCCGGCACAA GGTCTTTGTG ACCTTTCTCA GGGGAAGGGG CTTGATGGAA CCTTCTCTGA 1920
CTCATCTGGC AACCTGTCCC TAATGGTGAC CAAAGAAGAT AAAACATGAA CAGACCAAAA 1980
GCTAGGACAA GAGCTTGCTT CCCAAGACAG ACGTGTCTGT CTGCAAAGGC CTTGCCTCTA 2040
GTCCAGTCAG CTCTGGGGGA GTGGGAAGGA GATGCCCACC TCCTCTTTCT GTCTCAACAA 2100
TAGTCCCTAA TTAAGTACCT TCTGTGCGGC AGCCACCCAC TGAGGGTGGG CAAAGGCCCC 2160
TTGAAAGCAA AATTGGGGCT GGGCTCAGTG GCTCATGCCT ATAATCCCAG CACTTTGGGA 2220
GGCCAAGGCA GGCAGATCAC CTGAGGTCCG GAGTTCGAGA CCAGCCTGGC CAACGTGGTG 2280
AAACGCCATC TCCACTAAGA ATACAAAAAT ATGGCTCATG CCTGTAATCC CAGTACTTTG 2340
GGAGGCTGAG GTGGGCCGAT CATTTGAAGT TAGGAGTTTG AGACCAGCCT GACCAATATG 2400
GTAAAACCCC GTCTCTACTA AAAATACAAA AAAATTAGCC TGGCGTGGTG GCGCATGCCT 2460
GTAGTCCCAT AGGCTGTAGC TACTGGGAGG AGGCCCAGCT TGCAGTGAGC CGAGATCACG 2520
CCACTGCTCT CCAGCCTGGG CGACAGAGTG AGACTCTGTG TCAAAAACAA ACAAACAAAC 2580
AAAAAAGGCA AAATTGGAGC TGTCCAGGCC AGGACACCCC GATGTCCAGG GGCTTCCATA 2640
CGAACAGGCA CATGGGCTGG GAAGTACATG AGGCCCCTGG GTAGAAGGGT CTGTCAGTTC 2700
TCTCCTCCCT TGCCCTCTGG GAGGGTCCTC CTAACATAGC TTCCAGGAGG TGGGAGGAGC 2760
AGTTACTGTC AGCAGGTGTC AGCCAGGTGT CAGCTTCTCC TGGGGATCTC TAGATGTCTG 2820
CTTGTGATTT TTGGCAAGTA TATGCAAATG AGCCTCCTCT CCTGCCCTGA GACAAGTATC 2880
TGCAGTGTGA ACCTGGCAGC CTCAGACCCA AGGGGCTCAG AGGAAACTTC TCTGGTTTCT 2940
AGAGCTCTGT GCTCCTTCAG AGAAGTCTTC CTTCCTTCCA GTCAGTGTCC CTGTGAAGCT 3000
GGGATACTCA TTTCCTGTGT ACCGGGCAAA CACCGGATTG CTGATTTTGA GAAATGCCTC 3060
TCGATGGACC TGTAACCTGC TGGAGTCTGG GATGGTAGCT GTGGGCTGGA CTTGCCTGAT 120
GGGATGACCC GGTGGCTAGT GCAGCATCAC ACAAGCCTGG TTCAAGTCTT GGCTGTGTCA 3180
TTTCCTGCTG AGGGACCAGG CACTGAATTT CCTACCTCTT AGGGTCATTA CCTATGAGGT 3240
TAAAGCTACC TCATGGGATT GTTATACGCC AC AATGTTG AGGCAGACAC CTCTTGGCAG 3300
GGTGACTGCT CATCTTAGAC CCTCCCCTTT TCTGCGAATT TGGGCCCCTT GATCCTCTGA 3360
TGGGAGCTGA AAGGATGAGA GGTGGGCATC TAGATTTAGG GAGGCTGTTC AGGCTTTGCA 3420
GGTCCCTTAC CTGAACACAT AGAAACCCTG GAGCTGTGAC TGTGTCCATG TGTGTGTGTT 3480
TGTCTGTGTG TGTTGCGGGG GATGGGCACC TGCATGAATG TGGTAGAGAA AATGGCTCTG 3540
CTCAGAGGGA AGATACGCAT AGCAAGGCAG GGACCAGAGG AATCACAGGC GCCTGGAGAG 3600
CAGCCGGGCA CCGCCTCCAG GGACCTGCCG GCTTCCCTCA GTCCTCCAGG GGCCCAGCAC 3660
TCTTCCTTTA GGCCCTGTGA GCGTCCCTTG TCAGGATACA TTCTCTCATT TTGCTGAAGC 3720
TGATTTGATT GGGTGTCTGT TTCTCGCAGC CAAAAGAGCT CTGAATGAGG AAAGTGCTTC 3780
TGTGCTAACT CCCCGCGTCT CCTGAATTTC AGTCATTCAT GTACCCGCCT CGAAATTTTT 3840 GCAATATCTG TGTACCAACT GTCCATTTAC TTAATAAAGA AGTTTTCTTT AAATTAAGTC 3900 ACTTTTAA 3908
Seq ID NO 119 DNA Sequence
Nucleic Acid Accession ft NM_003271 2
Coding sequence 137 853
1 11 21 31 41 51
I I I I I I
GCGGGAGGCG GCGGCGCAGA GCTTGGGGCT TCCTTGGTCG CACCCACCAC CTGCCTGCCC 60 ACTGGTCAGC CTTCAGGGAC CCTGAGCACC GCCTGGTCTC TTTCCTGTGG CCAGCCCAGA 120 ACTGAAGCGC TGCGGCATCC CGCGCGCCTG CCTCCAGGCC GTCAAGTACC TCATGTTCGC 180 CTTCAACCTG CTCTTCTGGC TGGGAGGCTG TGGCGTGCTG GGTGTCGGCA TCTGGCTGGC 240 CGCCACACAG GGGAGCTTCG CCACGCTGTC CTCTTCCTTC CCGTCCCTGT CGGCTGCCAA 300 CCTGCTCATC ATCACCGGCG CCTTTGTCAT GGCCATCGGC TTCGTGGGCT GCCTGGGTGC 360 CATCAAGGAG AACAAGTGCC TCCTGCTCAC TTTCTTCCTG CTGCTGCTGC TGGTGTTCCT 420 GCTGGAGGCC ACCATCGCCA TCCTCTTCTT CGCCTACACG GACAAGATTG ACAGGTATGC 480 CCAGCAAGAC CTGAAGAAAG GCTTGCACCT GTACGGCACG CAGGGCAACG TGGGCCTCAC 540
CAACGCCTGG AGCATCATCC AGACCGACTT CCGCTGCTGT GGCGTCTCCA ACTACACTGA 600 CTGGTTCGAG GTGTACAACG CCACGCGGGT ACCTGACTCC TGCTGCTTGG AGTTCAGTGA 660 GAGCTGTGGG CTGCACGCCC CCGGCACCTG GTGGAAGGCG CCGTGCTACG AGACGGTGAA 720 GGTGTGGCTT CAGGAGAACC TGCTGGCTGT GGGCATCTTT GGGCTGTGCA CGCCGCTGGT 780 GCAGATCCTG GGCCTGACCT TCGCCATGAC CATGTACTGC CAAGTGGTCA AGGCAGACAC 840
CTACTGCGCG TAGGCCGCCC ACCGCCCGCT TCTCTGCCAA AAGGACGCCC ACGGGGAGAT 900
GGCCGCACCC ACAGCTGCCT TTCCCACCAC CAGCCTCGGT GCTCTGCCCC ATGCTGGGAG 960
GAGGGAGGGA GGGACAGGTG CCTGGAGCCC CCGGAACCCT GTTTCTGGAA GGCCCTAGCT 1020
CAGGTGGCTT CAGGGCCTCC GGACCCCCCC TGGGAGGGGT GGCCACGTGC TGGCTGCGGA 1080
ACCCAGGGCA GGGGTGGGAG GGGCCTCCAG CACTTTTTAT ATTTACGTAT TCTCCAAAGC 1140 AGTGTTCACA CGGGAGCCAG CCTGTGGCCC CCAGCCTCCT GGAAAACAGG TTGGCGCTGG 1200
AGGAGCCGGG TCTTCCCATC CTGGAGGTGG CCCCACTGGT CCTGGTGCTC CAGGCGGGGC 1260
CGTGGACCCC TCACCTACAT TCCATAGTGG GCCCGTGGGG CTCCTGGTGC ATCTTAATAA 1320
AGTGTGAGCA GCAAAAAAAA AAAAAAAAAA AAA 1353
Seq ID NO 120 DNA Sequence
Nucleic Acid Accession It N _005629 1
Coding sequence 639 2546
1 11 21 31 41 51 i i I i i i
TAGTCGCAGC GAGGTGGCGA GTCGCTGAGC CCGCCGCGGC CCCGAGAGCG GCTGCAGCCG 60
CCGCCGCCGG GAAGGAGAGG GCGAGGCGCG CCCGAGCCGC CGCCGCCGCC GCCACCGCCG 120
CCGCCGCCAC CACCGCCACC GGAGTCGCGG GCCAGCCGGG CAGCCTCCGC GGGCCCCGGC 180
CGGGGCGGGG GGCGCGGGCC ACACCCCCCT GCTCCGCCCG TCGTTTGCAG ACCGCGGGCG 2 0 CCGATGTCGC CCGCGCCCCG TTAGGATGAG TCTCGCGTCG GGCGAGGAGC CGCCGCAGCC 300
GCCGCCGCCC GAGCCGCCCG CAGGAGCCTC GGGAGCCGCC GCCGCCGCCG CCGCCGCCCG 360
GCCGGGCCCC GACGCCGCCC GCGCGCCCCC GGGCCCCCGA CACACATGAG ATTCTTCAGG 420
CTCACTTTCA AGTGCTTCGT GGACTGCTTC TGACTGCGCC GCCCGCGCCC CGCACCCCGC 480
CGTCCGCCCG CCGCCCCGTC CCCCGGCCCG GCCGCCCCCC GGCCCCCGGC CG CCCGCGC 540 CCTCGGGGCC CTCCCCGGTG CCGCCGGTGC CCCCCGCCTG ACCGCCGCCC CCCGTGAGGC 600
GCCGCGACCC CGGCCCGGCC GTGCGGCCCG CCGGGGCCAT GGCGAAGAAG AGCGCCGAGA 660
ACGGCATCTA TAGCGTGTCC GGCGACGAGA AGAAGGGCCC CCTCATCGCG CCCGGGCCCG 720
ACGGGGCCCC GGCCAAGGGC GACGGCCCCG TGGGCCTGGG GACACCCGGC GGCCGCCTGG 780
CCGTGCCGCC GCGCGAGACC TGGACGCGCC AGATGGACTT CATCATGTCG TGCGTGGGCT 840 TCGCCGTGGG CTTGGGCAAC GTGTGGCGCT TCCCCTACCT GTGCTACAAG AACGGCGGAG 900
GTGTGTTCCT TATTCCCTAC GTCCTGATCG CCCTGGTTGG AGGAATCCCC ATTTTCTTCT 960
TAGAGATCTC GCTCCGCCAG TTCATGAAGG CCGGCAGCAT CAATGTCTGG AACATCTGTC 1020
CCCTGTTCAA AGGCCTGGGC TACGCCTCCA TGGTGATCGT CTTCTACTGC AACACCTACT 1080
ACATCATGGT GCTGGCCTGG GGCTTCTATT ACCTGGTCAA GTCCTTTACC ACCACGCTGC 1140 CCTGGGCCAC ATGTGGCCAC ACCTGGAACA CTCCCGACTG CGTGGAGATC TTCCGCCATG 1200
AAGACTGTGC CAATGCCAGC CTGCCCAACC TCACCTGTGA CCAGCTTGCT GACCGCCGGT 1260
CCCCTGTCAT CGAGTTCTGG GAGAACAAAG TCTTGAGGCT GTCTGGGGGA CTGGAGGTGC 1 20
CACCGGCCCT CAACTCCGAG GTGACCCTTT GTCTGCTGGC CTGCTGGGTG CTGGTCTACT 1380
TCTGTGTCTG GAAGGGGGTC AAATCCACGG GAAAGATCGT GTACTTCACT GCTACATTCC 1440 CCTACGTGGT CCTGGTCGTG CTGCTCCTGC GTGGAGTGCT GCTGCCTGGC GCCCTGGATG 1500
GCATCATTTA CTATCTCAAG CCTGACTCCT CAAAGCTGGG GTCCCCTCAG GTGTGGATAG 1560
ATGCGGGGAC CCAGATTTTC TTTTCTTACG CCATTGGCCT GGGGGCCCTC ACAGCCCTGG 1620
GCAGCTACAA CCGCTTCAAC AACAACTGCT ACAAGGACGC CATCATCCTG GCTCTCATCA 1680
ACAGTGGGAC CAGCTTCTTT GCTGGCTTCG TGGTCTTCTC CATCCTGCGC TTCATGGCTG 1740 CAGAGCAGGG CGTGCACATC TCCAACCTGG CAGAGTCAGG GCCGGGCCTG GCCTTCATCG 1800
CCTACCCGCG GGCTGTCACG CTGATGCCAG TGGCCCCACT CTGGGCTGCC CTGTTCTTCT 1860
TCATGCTGTT GCTGCTTGGT CTCGACAGCC AGTTTGTAGG TGTGGAGGGC TTCATCACCG 1920
GCCTCCTCGA CCTCCTCCCG GCCTCCTACT ACTTCCGTTT CCAAAGGGAG ATCTCTGTGG 1980
CCCTCTGTTG TGCCCTCTGC TTTGTCATCG ATCTCTCCAT GGTGACTGAT GGCGGGATGT 2040 ACGTCTTCCA GCTGTTTGAC TACTACTCGG CCAGCGGCAC CACCCTGCTC TGGCAGGCCT 2100
TTTGGGAGTG CGTGGTGGTG GCCTGGGTGT ACGGAGCTGA CCGCTTCATG GACGACATTG 2160
CCTGTATGAT CGCGTACCGA CCTTGCCCCT GGATGAAATG GTGCTGGTCC TTCTTCACCC 2220
CGCTGGTCTG CATGGGCATC TTCATCTTCA ACGTTGTGTA CTACGAGCCG CTGGTCTACA 2280
ACAACACCTA CGTGTACCCG TGGTGGGGTG AGGCCATGGG CTGGGCCTTC GCCCTGTCCT 2340 CCATGCTGTG CGTGCCGCTG CACCTCCTGG GCTGCCTCCT CAGGGCCAAG GGCACCATGG 2400
CTGAGCGCTG GCAGCACCTG ACCCAGCCCA TCTGGGGCCT CCACCACTTG GAGTACCGAG 2460
CTCAGGACGC AGATGTCAGG GGCCTGACCA CCCTGACCCC AGTGTCCGAG AGCAGCAAGG 2520
TCGTCGTGGT GGAGAGTGTC ATGTGACAAC TCAGCTCACA TCACCAGCTC ACCTCTGGTA 2580
GCCATAGCAG CCCCTGCTTC AGCCCCACCG CACCCCTCCA GGGGGCCTGC CTTTCCCTGA 2640 CACTTTTGGG GTCTGCCTGG GGGAGGAGGG GAGAAAGCAC CATGAGTGCT CACTAAAACA 2700
ACTTTTTCCA TTTTTAATAA AACGCCAAAA ATATCACAAC CCACCAAAAA TAGATGCCTC 2760
TCCCCCTCCA GCCCTAGCCG AGCTGGTCCT AGGCCCCGCC TAGTGCCCCA CCCCCACCCA 2820
CAGTGCTGCA CTCCTCCTGC CCCTGCCACG CCCACCCCCT GCCCACCTCT CCAGGCTCTG 2880
CTCTGCAGCA CACCCGTGGG TGACCCCTCA CCCCAGAAGC AGCAGTGGCA GCTTGGGAAA 2940 TGTGAGGTΛG GGAAGGAGGG AGAGACGGGA GGGAGGAGAG AGAGGAGAAG GGAGGCAGGG 3000
GAGGGGCAGC AGAACCAAGG CAAATATTTC AGCTGGGCTA TACCCCTCTC CCCATCCCTG 3060
TTATAGAAGC TTAGAGAGCC AGCCAGCAAT GGAACCTTCT GGTTCCTGCG CCAATCGCCA 3120
CCAGTATCAA TTGTGTGAGC TTGGGTGCGA GTGCACGCGT GCGTGAGTAC GGAGAGTATA 3180
TATAGATCTC TATCTCTTAG CAAAGGTGAA TGCCAGATGT AAATGGCGCC TCTGGGCAAA 3240 GGAGGCTTGT ATTTTGCACA TTTTATAAAA ACTTGAGAGA ATGAGATTTC TGCTTGTATA 3300
TTTCTAAAAA GAGGAAGGAG CCCAAACCAT CCTCTCCTTA CCACTCCCAT CCCTGTGAGC 3360
CCTACCTTAC CCCTCTGCCC CTAGCCAAGG AGTGTGAATT TATAGATCTA ACTTTCATAG 3420
GCAAAACAAA AGCTTCGAGC TGTTGCGTGT GTGAGTCTGT TGTGTGGATG TGCGTGTGTG 3480
GTCCCCAGCC CCAGACTGGA TTGGAAAAGT GCATGGTGGG GGCCTCGGGG CTGTCCCCAC 3540 GCTGTCCCTT TGCCACAAGT CTGTGGGGCA AGAGGCTGCA ATATTCCGTC CTCCGTGTCT 3600
GGGCTGCTAA CCTGGCCTGC TCAGGCTTCC CACCCTGTGC GGGGCACACC CCCAGGAAGG 3660
GACCCTGGAC ACGGCTCCCA CGTCCAGGCT TAAGGTGGAT GCACTTCCCG CACCTCCAGT 3720
CTTCTGTGTA GCAGCTTTAA CCCACGTTTG TCTGTCACGT CCAGTCCCGA GACGGCTGAG 3780
TGACCCCAAG AAAGGCTTCC CCGACACCCA GACAGAGGCT GCAGGGCTGG GGCTGCGTGA 3840 GGGTGGCGGG CCTGCGGGGA CATTCTACTG TGCTAAAAAG CCACTGCAGA CATAGCAATA 3900
AAAACATGTC ATTTTCC 3917
Seq ID NO 121 DNA Sequence
Nucleic Acid Accession » NM_013332 1
Coding sequence 206 397
1 11 21 31 41 51
I I I I I I
GCACGAGGGC GCTTTTGTCT CCCCTGAGTT TTGTGGCCCG AAGCTTCTGC GCTGGTGCTT 60 AGTAACCGAC TTTCCTCCGG ACTCCTGCAC GACCTGCTCC TACAGCCGGC GATCCACTCC 120 CGCCTGTTCC CCCGGAGGGT CCAGAGGCCT TTCAGAAGGA GAAGGCAGCT CTGTTTCTCT 180
GCAGAGGAGT AGGGTCCTTT CAGCCATGAA GCATGTGTTG AACCTCTACC TGTTAGGTGT 240
GGTACTGACC CTACTCTCCA TCTTCGTTAG AGTGATGGAG TCCCTAGAAG GCTTACTAGA 300
GAGCCCATCG CCTGGGACCT CCTCCACCAC CAGAAGCCAA CTAGCCAACA CAGAGCCCAC 360 CAAGGGCCTT CCAGACCATC CATCCAGAAG CATGTGATAA GACCTCCTTC CATACTGGCC 420
ATATTTTGGA ACACTGACCT AGACATGTCC AGATGGGAGT CCCATTCCTA GCAGACAAGC 480
TGAGCACCGT TGTAACCAGA GAACTATTAC TAGGCCTTGA AGAACCTGTC TAACTGGATG 540
CTCATTGCCT GGGCAAGGCC TGTTTAGGCC GGTTGCGGTG GCTCATGCCT GTAATCCTAG 600
CACTTTGGGA GGCTGAGGTG GGTGGATCAC CTGAGGTCAG GAGTTCGAGA CCAGCCTCGC 660 CAACATGGCG AAACCCCATC TCTACTAAAA ATACAAAAGT TAGCTGGGTG TGGTGGCAGA 720
GGCCTGTAAT CCCAGTTCCT TGGGAGGCTG AGGCGGGAGA ATTGCTTGAA CCCGGGGACG 780
GAGGTTGCAG TGAACCGAGA TCGCACTGCT GTACCCAGCC TGGGCCACAG TGCAAGACTC 840
CATCTCAAAA AAAAAAAGAA AAGAAAAAGC CTGTTTAATG CACAGGTGTG AGTGGATTGC 900
TTATGGCTAT GAGATAGGTT GATCTCGCCC TTACCCCGGG GTCTGGTGTA TGCTGTGCTT 960 TCCTCAGCAG TATGGCTCTG ACATCTCTTA GATGTCCCAA CTTCAGCTGT TGGGAGATGG 1020
TGATATTTTC AACCCTACTT CCTAAACATC TGTCTGGGGT TCCTTTAGTC TTGAATGTCT 1080
TATGCTCAAT TATTTGGTGT TGAGCCTCTC TTCCACAAGA GCTCCTCCAT GTTTGGATAG 1140
CAGTTGAAGA GGTTGTGTGG GTGGGCTGTT GGGAGTGAGG ATGGAGTGTT CAGTGCCCAT 1200
TTCTCATTTT ACATTTTAAA GTCGTTCCTC CAACATAGTG TGTATTGGTC TGAAGGGGGT 1260 GGTGGGATGC CAAAGCCTGC TCAAGTTATG GACATTGTGG CCACCATGTG GCTTAAATGA 1320
TTTTTTCTAA CTAATAAAGT GGAATATATA TTTCAAAAAA AAAAAAAAAA AA 1372
Seq ID NO: 122 DNA Sequence Nucleic Acid Accession tt: NM_020142.2 Coding sequence: 274..537
1 11 21 31 41 51
I I I I I I
GGCACGAGGG TCTCCGCCTG CAGGTGCAGA CATCTGGAGG AGAGAGTCGG AGAGCAGAAA 60
CCACTTGGCT CCCAGACAAT TCCCCTACAG GCTTTGGGCC TGGAATTGAG GAGAAAGTGA 120
GCTAAGTTGG GGTGGGGTGA GTCCAAAGAA GCACGGGCTG GGCCAAGCTA AGCTGCTCTG 180
GGCTGGGCTG ATCCCTCCCC ACTCAGGGGC GGGACCCCAG GAGGAGGGAG AGGACAGAGC 240
CACTGCAGAG GACCAGACTG GGAAAACAAC GATATGGCAG GAGCCAGTCT TGGGGCCCGC 300
TTCTACCGGC AGATCAAAAG ACATCCGGGG ATCATCCCGA TGATCGGCTT AATCTGCCTG 360
GGCATGGGCA GCGCTGCGCT TTACTTGCTG CGACTCGCCC TTCGCAGCCC CGACGTCTGC 420
TGGGACAGAA AGAACAACCC GGAGCCCTGG AACCGCCTGA GCCCCAATGA CCAATACAAG 480
TTCCTTGCAG TTTCCACTGA CTATAAGAAG CTGAAGAAGG ACCGGCCAGA CTTCTAAGCC 540
AGGCTGGGCT GCCAGTGCCA TGCAAGCCAC AGCCAGCCAG CCCATCCACT TCTTCCACTC 600
CTCCCCGCAG GCCCCAAGGC ATCACTCCGG CCACCCTGTC CCGCTACTGC TTACACAGGC 660
CGGGTTCCCA CGCAGAGGGG AGGCTGCTCC ACCCCTACTC TCCTCCCTTG CTCCCAGCAG 720
CGGAAGCGCC TCTGACCCTT GGCTTGAGTC CCACGTGGGG GAGGAGGAGG CAGGCAGCAC 780
CAGCAGGGGT CCACCAAGAG CCCAGACCAG CCCCTCTGCC CTCCTACCCG GGCCTCGAAG 840
GGTGTGGCAC AGGCTACGTG TTGAGCGTGG CCTACGTGAG CCAACAAGAA GCAGGGGCCT 900
CTGAGTGCCA AGCGACGTGG CGGGCTCCAC GTTAGCCCAG GCTCTGAGAG CCAGCCCAGG 960
GGCGGCGCTG CTCAGCTTGG GCTGGTCCAG GGCCTGCCCA GGCTGGGGCA CCTTTGCCTC 1020
CTGAGGCGCA GCGCACTCCT CCCCTGCCCA AGCCTACTGC CTCCCGCTGC CGCCAGTACC 1080
CCCTCCAGCC CCACACCTGG GCCTCCCCCT GCCACTCCCC TCCCTTGCTC CCCTCTGTCC 1140
CCAG GATCA AACAGAAGCA GCCGTGGGCA AAATACAATT TCATTTAACA AATTGAAAAA 1200
AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 1260
AAAAAAAAAA AAAAAAAAAA AAAA 1284
Seq ID NO: 123 DNA Sequence
Nucleic Acid Accession it : Eos sequence
1 11 21 31 41 51
I I I I I I
TCTTGACTGA AATTCTCTCC TGATGCTGAG CCCTGCACCC CACCTTCCTT TTCCTAACTA 60
TGAATTGATG GCAAAGTCCA CTCAAAACAA CCAGTTAAGT GCTCACGAGA GAGTAGTCAA 120
GCACCTCCAG AAAGAAACCG GGTTTTTGTT CACATAGCAG GAAGTGACTC CCTCCGTGGT 180
AATTTATCTT GGAAACACAG GTAGATTGGC AGAAAAACGG GAACATGTAG GTACCGCGAT 240
GTTGGTGCAT GTCCATTACT TTGGGATAGG CTTTCTCAGT CTTTCCTCAA ATGATAGTTG 300
AGCCAGTTTT CCAGTGGCAA TTCTGAGTGA CTTGCGCTTG TCTTATGGTG TGGTCAAGGG 360
ACGTTCAGAA CTACGGAAAA CTTTTACTGA AACAGCGAAG CAGAGTATAC CGGCATGAGA 420
GGGAAGATGA ACACTCACCT ATGTACCACT CTTTGACAAT AAATATAGTA TTTCTCAAAT 480
CAGTCTCAAG ACTGATCCTG TCTCAGAACA GACCATTGTT CTCTCATTTC TCTAATACGC 540
TGAGAGGAAC ACTCTGAATA AAGGCTAAGT GGTGGAGCAT GCAA 584
Seq ID NO: 124 DNA Sequence
Nucleic Acid Accession tt : NM_002204.1
Coding sequence- 74..3229
1 11 21 31 41 51
I I I I I I
AGGTGAACAG GTCCTCACGC CCAGCTCCGC CCCCTCACGC GCTCTCGCCG GGACCCCGCT 60
TCCGCTGGCA GCCATGGGCC CCGGCCCCAG CCGCGCGCCC CGCGCCCCAC GCCTGATGCT 120
CTGTGCGCTC GCCTTGATGG TGGCGGCCGG CGGCTGCGTC GTCTCCGCCT TCAACCTCCA 180
TACCCGATTC CTGGTAGTGA AGGAGGCCGG GAACCCGGGC AGCCTCTTCG GCTACTCGGT 240
CGCCCTCCAT CGGCAGACAG AGCGGCAGCA GCGCTACCTG CTCCTGGCTG GTGCCCCCCG 300
GGAGCTCGCT GTGCCCGATG GCTACACCAA CCGGACTGGT GCTGTGTACC TGTGCCCACT 360
CACTGCCCAC AAGGATGACT GTGAGCGGAT GAACATCACA GTGAAAAATG ACCCTGGCCA 420
TCACATTATT GAGGACATGT GGCTTGCAGT GACTGTGGCC AGCCAGGGCC CTGCAGGCAG 480
AGTTCTGGTC TGTGCCCACC GCTACACCCA GGTGCTGTGG TCAGGGTCAG AAGACCAGCG 540
GCGCATGGTG GGCAAGTGCT ACGTGCGAGG CAATGACCTA GAGCTGGACT CCAGTGATGA 600
CTGGCAGACC TACCACAACG AGATGTGCAA TAGCAACACA GACTACCTGG AGACGCGCAT 660
GTGCCAGCTG GGCACCAGCG GTGGCTTCAC CCAGAACACT GTGTACTTCG GCGCCCCCGG 720
TGCCTACAAC TGGAAAGGAA ACAGCTACAT GATTCAGCGC AAGGAGTGGG ACTTATCTGA 780
GTATAGTTAC AAGGACCCAG AGGACCAAGG AAACCTCTAT ATTGGGTACA CGATGCAGGT 840 AGGCAGCTTC ATCCTGCACC CCAAAAACAT CACCATTGTG ACAGGTGCCC CACGGCACCG 900
ACATATGGGC GCCCTGTTCT TGCTGAGCCA GGAGGCAGGC GGAGACCTGC GGAGGAGGCA 960
GGTGCTGGAG GGCTCGCAGG TGGGCGCCTA TTTTGGCAGC GCAATTGCCC TGGCAGACCT 1020
GAACAATGAT GGGTGGCAGG ACCTCCTGGT GGGCGCCCCC TACTACTTCG AGAGGAAAGA 1080 GGAAGTAGGG GGTGCCATCT ATGTCTTCAT GAACCAGGCG GGAACCTCCT TCCCTGCTCA 1140
CCCCTCACTC CTTCTTCATG GCCCCAGTGG CTCTGCCTTT GGTTTATCTG TGGCCAGCAT 1200
TGGTGACATC AACCAGGATG GATTTCAGGA TATTGCTGTG GGAGCTCCGT TTGAAGGCTT 1260
GGGCAAAGTG TACATCTATC ACAGTAGCTC TAAGGGGCTC CTTAGACAGC CCCAGCAGGT 1320
AATCCATGGA GAGAAGCTGG GACTGCCTGG GTTGGCCACC TTCGGCTATT CCCTCAGTGG 1380 GCAGATGGAT GTGGATGAGA ACTTCTACCC AGACCTTCTA GTGGGAAGCC TGTCAGACCA 1440
CATTGTGCTG CTGCGGGCCC GGCCAGTCAT CAACATCGTC CACAAGACCT TGGTGCCCAG 1500
GCCAGCTGTG CTGGACCCTG CACTTTGCAC GGCCACCTCT TGTGTGCAAG TGGAGCTGTG 1560
CTTTGCTTAC AACCAGAGTG CCGGGAACCC CAACTACAGG CGAAACATCA CCCTGGCCTA 1620
CACTCTGGAG GCTGACAGGG ACCGCCGGCC GCCCCGGCTC CGCTTTGCCG GCAGTGAGTC 1680 CGCTGTCTTC CACGCCTTCT TCTCCATGCC CGAGATGCGC TGCCAGAAGC TGGAGCTGCT 1740
CCTGATGGAC AACCTCCGTG ACAAACTCCG CCCCATCATC ATCTCCATGA ACTACTCTTT 1800
ACCTTTGCGG ATGCCCGATC GCCCCCGGCT GGGGCTGCGG TCCCTGGACG CCTACCCGAT 1860
CCTCAACCAG GCACAGGCTC TGGAGAACCA CACTGAGGTC CAGTTCCAGA AGGAGTGCGG 1920
GCCTGACAAC AAGTGTGAGA GCAACTTGCA GATGCGGGCA GCCTTCGTGT CAGAGCAGCA 1980 GCAGAAGCTG AGCAGGCTCC AGTACAGCAG AGACGTCCGG AAATTGCTCC TGAGCATCAA 2040
CGTGACGAAC ACCCGGACCT CGGAGCGCTC CGGGGAGGAC GCCCACGAGG CGCTGCTCAC 2100
CCTGGTGGTG CCTCCCGCCC TGCTGCTGTC CTCAGTGCGC CCCCCCGGGG CCTGCCAAGC 2160
TAATGAGACC ATCTTTTGCG AGCTGGGGAA CCCCTTCAAA CGGAACCAGA GGATGGAGCT 2220
GCTCATCGCC TTTGAGGTCA TCGGGGTGAC CCTGCACACA AGGGACCTTC AGGTGCAGCT 2280 GCAGCTCTCC ACGTCGAGTC ACCAGGACAA CCTGTGGCCC ATGATCCTCA CTCTGCTCCT 2340
GGACTATACA CTCCAGACCT CGCTTAGCAT GGTAAATCAC CGGCTACAAA GCTTCTTTGG 2400
GGGGACAGTG ATGGGTGAGT CTGGCATGAA AACTGTGGAG GATGTAGGAA GCCCCCTCAA 2460
GTATGAATTC CAGGTGGGCC CAATGGGGGA GGGGCTGGTG GGCCTGGGGA CCCTGGTCCT 2520
AGGTCTGGAG TGGCCCTACG AAGTCAGCAA TGGCAAGTGG CTGCTGTATC CCACGGAGAT 2580 CACCGTCCAT GGCAATGGGT CCTGGCCCTG CCGACCACCT GGAGACCTTA TCAACCCTCT 2640
CAACCTCACT CTTTCTGACC CTGGGGACAG GCCATCATCC CCACAGCGCA GGCGCCGACA 2700
GCTCCATCCA GGGGGAGGCC AGGGCCCCCC ACCTGTCACT CTGGCTGCTG CCAAAAAAGC 2760
CAAGTCTGAG ACTGTGCTGA CCTGTGCCAC AGGGCGTGCC CACTGTGTGT GGCTAGAGTG 2820
CCCCATCCCT GATGCCCCCG TTGTCACCAA CGTGACTGTG AAGGCACGAG TGTGGAACAG 2880 CACCTTCATC GAGGATTACA GAGACTTTGA CCGAGTCCGG GTAAATGGCT GGGCTACCCT 2940
ATTCCTCCGA ACCAGCATCC CCACCATCAA CATGGAGAAC AAGACCACGT GGTTCTCTGT 3000
GGACATTGAC TCCCAGCTGG TGGAGGAGCT GCCGGCCGAA ATCGAGCTGT GGCTGCTGCT 3060
GGTGGCCGTG GGTGCAGGGC TGCTGCTGCT GGGGCTGATC ATCCTCCTGC TGTGGAAGTG 3120
CGGCTTCTTC AAGCGAGCCC GCACTCGCGC CCTGTATGAA GCTAAGAGGC AGAAGGCGGA 3180 GATGAAGAGC CAGCCGTCAG AGACAGAGAG GCTGACCGAC GACTACTGAG GGGGCAGCCC 3240
CCCGCCCCCG GCCCACCTGG TGTGACTTCT TTAAGCGGAC CCGCTATTAT CAGATCATGC 3300
CCAAGTACCA CGCAGTGCGG ATCCGGGAGG AGGAGCGCTA CCCACCTCCA GGGAGCACCC 3360
TGCCCACCAA GAAGCACTGG GTGACCAGCT GGCAGACTCG GGACCAATAC TACTGACGTC 3420
CTCCCTGATC CCACCCCCTC CTCCCCCAGT GTCCCCTTTC TTCCTATTTA TCATAAGTTA 3480 TGCCTCTGAC AGTCCACAGG GGCCACCACC TTTGGCTGGT AGCAGCAGGC TCAGGCACAT 3540
ACACCTCGTC AAGAGCATGC ACATGCTGTC TGGCCCTGGG GATCTTCCCA CAGGAGGGCC 3600
AGCGCTGTGG ACCTTACAAC GCCGAGTGCA CTGCATTCCT GTGCCCTAGA TGCACGTGGG 3660
GCCCACTGCT CGTGGACTGT GCTGGTGCAT CACGGATGGT GCATGGGCTC GCCGTGTCTC 3 20
AGCCTCTGCC AGCGCCAGCG CCAAAACAAG CCAAAGAGCC TCCCACCAGA GCCGGGAGGA 3780 AAAGGCCCCT GCAATGTGGT GACACCTCCC CTTTCACACC TGGATCCATC TTGAGAGCCA 3840
CAGTCACTGG ATTGACTTTG CTGTCAAAAC TACTGACAGG GAGCAGCCCC CCCGCCGCTG 3900
GCTGGTGGGC CCCCAATTGA CACCCATGCC AGAGAGGTGG GGATCCTGCC TAAGGTTGTC 3960
TACGCGGCCA CTTGGAGGAC CTGGCGTGCT CAGACCCAAC AGCAAAGGAA CTAGAAAGAA 4020
GGACCCAGAA GGCTTGCTTT CCTGCATCTC TGTGAAGCCT CTCTCCTTGG CCACAGACTG 4080 AACTCGCAGG GAGTGCAGCA GGAAGGAACA AAGACAGGCA AACGGCAACG TAGCCTGGGC 4140
TCACTGTGCT GGGGCATGGC GGGATCCTCC ACAGAGAGGA GGGGACCAAT TCTGGACAGA 4200
CAGATGTTGG GAGGATACAG AGGAGATGCC ACTTCTCACT CACCACTACC AGCCAGCCTC 4260
CAGAAGGCCC CAGAGAGACC CTGCAAGACC ACGGAGGGAG CCGACACTTG AATGTAGTAA 4320
TAGGCACCGG GCCCTGCCAC CCCATCCAGC CAGACCCCAG CTGAACCATG CGTCAGGGGC 4380 CTAGAGGTGG AGTTCTTAGC TATCCTTGGC TTTCTGTGCC AGCCTGGCTC TGCCCCTCCC 4440
CCATGGGCTG TGTCCTAAGG CCCATTTGAG AAGCTGAGGC TAGTTCCAAA AACCTCTCCT 4500
GACCCCTGCC TGTTGGCAGC CCACTCCCCA GCCCCAGCCC CTTCCATGGT ACTGTAGCAG 4560
GGGAATTCCC TCCCCCTCCT TGTGCCTTCT TTGTATATAG GCTTCTCACC GCGACCAATA 4620
AACAGCTCCC AGTTTGT 4637
Seq ID NO 125 DNA Sequence
Nucleic Acid Accession tt NM_005501 1
Coding sequence 74 3274
1 11 21 31 41 51 i i i i i i
AGGTGAACAG GTCCTCACGC CCAGCTCCGC CCCCTCACGC GCTCTCGCCG GGACCCCGCT 60
TCCGCTGGCA GCCATGGGCC CCGGCCCCAG CCGCGCGCCC CGCGCCCCAC GCCTGATGCT 120
CTGTGCGCTC GCCTTGATGG TGGCGGCCGG CGGCTGCGTC GTCTCCGCCT TCAACCTGGA 180
TACCCGATTC CTGGTAGTGA AGGACGCCCC GAACCCGGGC AGCCTCTTCG GCTACTCGGT 240
CGCCCTCCAT CGGCAGACAG AGCGGCAGCA GCGCTACCTG CTCCTGGCTG GTGCCCCCCG 300
GGAGCTCGCT GTGCCCGATG GCTACACCAA CCGGACTGGT GCTGTGTACC TGTGCCCACT 360
CACTGCCCAC AAGGATGACT GTGAGCGGAT GAACATCACA GTGAAAAATG ACCCTGGCCA 420
TCACATTATT GAGGACATGT GGCTTGGAGT GACTGTGGCC AGCCAGCGCC CTGCAGGCAG 480
AGTTCTGGTC TGTGCCCACC GCTACACCCA GGTGCTGTGG TCAGGGTCAG AAGACCAGCG 540
GCGCATGGTG GGCAAGTGCT ACGTGCGAGG CAATGACCTA GAGCTGGACT CCAGTGATGA 600
CTGGCAGACC TACCACAACG AGATGTGCAA TAGCAACACA GACTACCTGG AGACGGGCAT 660
GTGCCAGCTG GGCACCAGCG GTGGCTTCAC CCAGAACACT GTGTACTTCG GCGCCCCCCC 720
TGCCTACAAC TGGAAAGGAA ACAGCTACAT GATTCAGCGC AAGGAGTGGG ACTTATCTGA 780
GTATAGTTAC AAGGACCCAG AGGACCAAGG AAACCTCTAT ATTGGGTACA CGATGCACCT 840 AGGCAGCTTC ATCCTGCACC CCAAAAACAT CACCATTGTG ACAGGTGCCC CACGGCACCG 900
ACATATGGGC GCGGTGTTCT TGCTGAGCCA GGAGGCAGGC GGAGACCTGC GGAGGAGGCA 960
GGTGCTGGAG GGCTCGCAGG TGGGCGCCTA TTTTGGCAGC GCAATTGCCC TGGCAGACCT 1020
GAACAATGAT GGGTGGCAGG ACCTCCTGGT GGGCGCCCCC TACTACTTCG AGAGGAAAGA 1080
GGAAGTAGGG GGTGCCATCT ATGTCTTCAT GAACCAGGCG GGAACCTCCT TCCCTGCTCA 1140
CCCCTCACTC CTTCTTCATG GCCCCAGTGG CTCTGCCTTT GGTTTATCTG TGGCCAGCAT 1200
TGGTGACATC AACCAGGATG GATTTCAGGA TATTGCTGTG GGAGCTCCGT TTGAAGGCTT 1260
GGGCAAAGTG TACATCTATC ACAGTAGCTC TAAGGGGCTC CTTAGACAGC CCCAGCAGGT 1320
AATCCATGGA GAGAAGCTGG GACTGCCTGG GTTGGCCACC TTCGGCTATT CCCTCAGTGG 1380
GCAGATGGAT GTGGATGAGA ACTTCTACCC AGACCTTCTA GTGGGAAGCC TGTCAGACCA 1440
CATTGTGCTG CTGCGGGCCC GGCCAGTCAT CAACATCGTC CACAAGACCT TGGTGCCCAG 1500
GCCAGCTGTG CTGGACCCTG CACTTTGCAC GGCCACCTCT TGTGTGCAAG TGGAGCTGTG 1560
CTTTGCTTAC AACCAGAGTG CCGGGAACCC CAACTACAGG CGAAACATCA CCCTGGCCTA 1620
CACTCTGGAG GCTGACAGGG ACCGCCGGCC GCCCCGGCTC CGCTTTGCCG GCAGTGAGTC 1680
CGCTGTCTTC CACGGCTTCT TCTCCATGCC CGAGATGCGC TGCCAGAAGC TGGAGCTGCT 1740
CCTGATGGAC AACCTCCGTG ACAAACTCCG CCCCATCATC ATCTCCATGA ACTACTCTTT 1800
ACCTTTGCGG ATGCCCGATC GCCCCCGGCT GGGGCTGCGG TCCCTGGACG CCTACCCGAT 1860
CCTCAACCAG GCACAGGCTC TGGAGAACCA CACTGAGGTC CAGTTCCAGA AGGAGTGCGC 1920
GCCTGACAAC AAGTGTGAGA GCAACTTGCA GATGCGGGCA GCCTTCGTGT CAGAGCAGCA 1980 GCAGAAGCTG AGCACCCTCC AGTACAGCAG AGACGTCCGG AAATTGCTCC TGAGCATCAA 2040
CGTGACGAAC ACCCGGACCT CG AGCGCTC CGGGGAGGAC GCCCACGAGG CGCTGCTCAC 2100
CCTGGTGGTG CCTCCCGCCC TGCTGCTGTC CTCAGTGCGC CCCCCCGGGG CCTGCCAAGC 2160
TAATGAGACC ATCTTTTGCG AGCTGGGGAA CCCCTTCAAA CGGAACCAGA GGATGGAGCT 2220
GCTCATCGCC TTTGAGGTCA TCGGGGTGAC CCTGCACACA AGGGACCTTC AGGTGCAGCT 2280
GCAGCTCTCC ACGTCGAGTC ACCAGGACAA CCTGTGGCCC ATGATCCTCA CTCTGCTGGT 2340
GGACTATACA CTCCAGACCT CGCTTAGCAT GGTAAATCAC CGGCTACAAA GCTTCTTTGG 2400
GGGGACAGTG ATGGGTGAGT CTGGCATGAA AACTGTGGAG GATGTAGGAA GCCCCCTCAA 2460
GTATGAATTC CAGGTGGGCC CAATGGGGGA GGGGCTGGTG GGCCTGGGGA CCCTGGTCCT 2520
AGGTCTGGAG TGGCCCTACG AAGTCAGCAA TGGCAAGTGG CTGCTGTATC CCACGGAGAT 2580
CACCGTCCAT GGCAATGGGT CCTGGCCCTG CCGACCACCT GGAGACCTTA TCAACCCTCT 2640
CAACCTCACT CTTTCTGACC CTGGGGACAG GCCATCATCC CCACAGCGCA GCCGCCGACA 2700
GCTGGATCCA GGGGGAGGCC AGGGCCCCCC ACCTGTCACT CTGGCTGCTG CCAAAAAAGC 2760
CAAGTCTGAG ACTGTGCTGA CCTGTGCCAC AGGGCGTGCC CACTGTGTGT GGCTAGAGTG 2820
CCCCATCCCT GATGCCCCCG TTGTCACCAA CGTGACTGTG AAGGCACGAG TGTGGAACAG 2880
CACCTTCATC GAGGATTACA GAGACTTTGA CCGAGTCCGG GTAAATGGCT GGGCTACCCT 2940
ATTCCTCCGA ACCAGCATCC CCACCATCAA CATGGAGAAC AAGACCACGT GGTTCTCTGT 3000
GGACATTGAC TCGGAGCTGG TGGAGGAGCT GCCGGCCGAA ATCGAGCTGT GGCTGGTGCT 3060
GGTGGCCGTG GGTGCACCGC TGCTGCTGCT GGGGCTGATC ATCCTCCTGC TGTGGAAGTG 3120
TGACTTCTTT AAGCGGACCC GCTATTATCA GATCATGCCC AAGTACCACG CAGTGCCCAT 3180
CCGGGAGGAG GAGCGCTACC CACCTCCAGG GAGCACCCTG CCCACCAAGA AGCACTGGGT 3240
GACCAGCTGG CAGACTCGGG ACCAATACTA CTGACGTCCT CCCTGATCCC ACCCCCTCCT 3300
CCCCCAGTGT CCCCTTTCTT CCTATTTATC ATAAGTTATG CCTCTGACAG TCCACAGGGG 3360
CCACCACCTT TGGCTCCTAG CAGCAGGCTC AGGCACATAC ACCTCGTCAA GAGCATGCAC 3420
ATGCTGTCTG GCCCTGGGGA TCTTCCCACA GGAGGGCCAG CGCTGTGGAC CTTACAACGC 3 80
CGAGTGCACT GCATTCCTGT GCCCTAGATG CACGTGGGGC CCACTGCTCG TGGACTGTGC 3540
TGGTGCATCA CGGATGGTGC ATGGGCTCGC CGTGTCTCAG CCTCTGCCAG CGCCAGCGCC 3600
AAAACAAGCC AAAGAGCCTC CCACCAGAGC CGGGAGGAAA AGGCCCCTGC AATGTGGTGA 3660
CACCTCCCCT TTCACACCTG GATCCATCTT GAGAGCCACA GTCACTGGAT TGACTTTGCT 3720
GTCAAAACTA CTGACACCGA GCAGCCCCCG GGCCGCTGGC TGGTGGGCCC CCAATTGACA 3780
CCCATGCCAG AGAGGTGGGG ATCCTGCCTA AGGTTGTCTA CGGGGGCACT TGGAGGACCT 3840
GGCGTGCTCA GACCCAACAG CAAAGGAACT AGAAAGAAGG ACCCAGAAGG CTTGCTTTCC 3900
TGCATCTCTG TGAAGCCTCT CTCCTTGGCC ACAGACTGAA CTCGCAGGGA GTGCAGCAGG 3960
AAGGAACAAA GACAGGCAAA CGGCAACGTA GCCTGGGCTC ACTGTGCTGG GGCATGGCGG 4020
GATCCTCCAC AGAGAGGAGG GGACCAATTC TGGACAGACA GATGTTGGGA GGATACAGAG 4080
GAGATGCCAC TTCTCACTCA CCACTACCAG CCAGCCTCCA GAAGGCCCCA GAGAGACCCT 4140
GCAAGACCAC GGAGGGAGCC GACACTTGAA TGTAGTAATA GGCAGGGGGC CCTGCCACCC 4200
CATCCAGCCA GACCCCAGCT GAACCATGCG TCACCGGCCT AGAGGTGGAG TTCTTAGCTA 4260
TCCTTGGCTT TCTGTGCCAG CCTGCCTCTG CCCCTCCCCC ATGGGCTGTG TCCTAAGGCC 4320
CATTTGAGAA GCTGAGGCTA GTTCCAAAAA CCTCTCCTGA CCCCTGCCTG TTGGCAGCCC 4380
ACTCCCCAGC CCCAGCCCCT TCCATGGTAC TGTAGCAGGG GAATTCCCTC CCCCTCCTTG 4440
TGCCTTCTTT GTATATAGGC TTCTCACCGC GACCAATAAA CAGCTCCCAG TTTGT 4495
Seq ID NO 126 DNA Sequence
Nucleic Acid Accession tt NM_003786
Coding sequence 71 4654
1 11 21 31 41 51
I I I I I I
CTCCGGCGCC CGCTCTGCCC GCCGCTGGGT CCGACCGCGC TCGCCTTCCT TGCAGCCGCG 60
CCTCGGCCCC ATGGACGCCC TGTGCGGTTC CCCGGAGCTC GGCTCCAAGT TCTGCCACTC 120
CAACCTGTCT GTGCACACAG AAAACCCGGA CCTCACTCCC TGCTTCCAGA ACTCCCTGCT 180
GGCCTGGGTG CCCTGCATCT ACCTGTGGGT CGCCCTGCCC TGCTACTTGC TCTACCTGCG 240
GCACCATTGT CGTGGCTACA TCATCCTCTC CCACCTGTCC AAGCTCAAGA TGGTCCTGGG 300
TGTCCTGCTG TGGTGCGTCT CCTGGGCCCA CCTTTTTTAC TCCTTCCATG GCCTGGTCCA 360
TGGCCGGGCC CCTGCCCCTG TTTTCTTTGT CACCCCCTTG GTGGTGGGGG TCACCATGCT 420
GCTGGCCACC CTGCTGATAC AGTATGAGCG GCTGCAGGGC GTACAGTCTT CGGGGGTCCT 480
CATTATCTTC TGGTTCCTGT GTGTGGTCTG CGCCATCGTC CCATTCCGCT CCAAGATCCT 540
TTTAGCCAAG GCAGAGGGTG AGATCTCAGA CCCCTTCCGC TTCACCACCT TCTACATCCA 600
CTTTGCCCTG GTACTCTCTG CCCTCATCTT GGCCTGCTTC AGGGAGAAAC CTCCATTTTT 660
CTCCGCAAAG AATGTCGACC CTAACCCCTA CCCTGAGACC AGCGCTGGCT TTCTCTCCCG 720
CCTGTTTTTC TGGTGGTTCA CAAAGATGGC CATCTATGGC TACCGGCATC CCCTGGAGGA 780
GAAGGACCTC TGGTCCCTAA AGGAAGAGGA CAGATCCCAG ATGGTGGTGC AGCAGCTGCT 840
GGAGGCATGG AGGAAGCAGG AAAAGCAGAC GGCACGACAC AAGGCTTCAG CAGCACCTGC 900
GAAAAATGCC TCCGGCGAGG ACGAGGTGCT GCTGGGTGCC CCCCCCAGGC CCCGGAAGCC 960
CTCCTTCCTG AAGGCCCTGC TGGCCACCTT CGGCTCCAGC TTCCTCATCA GTGCCTGCTT 1020 CAAGCTTATC CAGCACCTGC TCTCCTTCAT CAATCCACAG CTGCTCAGCA TCCTGATCAG 1080
GTTTATCTCC AACCCCATGG CCCCCTCCTG GTGGGGCTTC CTGGTGGCTG GGCTGATGTT 1140
CCTGTGCTCC ATGATGCAGT CGCTGATCTT ACAACACTAT TACCACTACA TCTTTGTGAC 1200
TGGGGTGAAG TTTCGTACTG GGATCATGGG TGTCATCTAC AGGAAGGCTC TGGTTATCAC 1260
CAACTCAGTC AAACGTGCGT CCACTGTGGG GGAAATTGTC AACCTCATGT CAGTGGATGC 1320
CCAGCGCTTC ATGGACCTTG CCCCCTTCCT CAATCTGCTG TGGTCAGCAC CCCTGCAGAT 1380
CATCCTGGCG ATCTACTTCC TCTGCCAGAA CCTAGGTCCC TCTGTCCTCC CTGGAGTCGC 1440
TTTCATGGTC TTGCTGATTC CACTCAACGG AGCTGTGGCC GTGAAGATGC GCGCCTTCCA 1500
GGTAAAGCAA ATGAAATTGA AGGACTCGCG CATCAAGCTG ATGAGTGAGA TCCTGAACCC 1560
CATCAAGGTG CTGAAGCTGT ACGCCTGGGA GCCCAGCTTC CTGAAGCAGG TGGAGGGCAT 1620
CAGGCAGCGT GAGCTCCAGC TGCTGCGCAC GGCGGCCTAC CTCCACACCA CAACCACCTT 1680
CACCTGGATG TGCAGCCCCT TCCTGCTGAC CCTGATCACC CTCTGGGTGT ACGTGTACGT 1740
GGACCCAAAC AATGTGCTCC ACGCCGAGAA GGCCTTTGTG TCTGTGTCCT TGTTTAATAT 1800
CTTAAGACTT CCCCTCAACA TGCTGCCCCA GTTAATCAGC AACCTGACTC AGGCCAGTGT 1860
GTCTCTGAAA CGGATCCAGC AATTCCTGAG CCAAGAGGAA CTTGACCCCC AGAGTGTGGA 1920
AAGAAAGACC ATCTCCCCAG GCTATGCCAT CACCATACAC AGTGGCACCT TCACCTCCGC 1980
CCAGGACCTG CCCCCCACTC TGCACAGCCT AGACATCCAG GTCCCGAAAG GGGCACTGGT 2040
GGCCGTGGTG GGGCCTGTGG GCTGTGGGAA GTCCTCCCTG GTGTCTGCCC TGCTGGGAGA 2100
GATGGAGAAG CTAGAAGGCA AAGTGCACAT GAAGGGCTCC GTGGCCTATG TGCCCCAGCA 2160
GCCATGGATC CAGAACTGCA CTCTTCAGGA AAACGTGCTT TTCGGCAAAG CCCTGAACCC 2220
CAAGCGCTAC CAGCAGACTC TGGAGGCCTG TGCCTTGCTA GCTGACCTGG AGATGCTGCC 2280
TGGTGGGGAT CAGACAGAGA TTGCAGAGAA GGGCATTAAC CTGTCTCCGG GCCAGCGGCA 2340
GCGGGTCAGT CTGGCTCGAG CTGTTTACAG TGATGCCGAT ATTTTCTTGC TGGATGACCC 2400
ACTGTCCGCG GTGGACTCTC ATGTGGCCAA GCACATCTTT GACCACGTCA TCGGGCCAGA 2460
AGGCGTGCTG GCAG CAAGA CGCGAGTGCT GGTGACGCAC GGCATTAGCT TCCTGCCCCA 2520
GACAGACTTC ATCATTGTGC TAGCTGATGG ACAGGTGTCT GAGATGGGCC CGTACCCAGC 2580
CCTGCTGCAG CGCAACGGCT CCTTTGCCAA CTTTCTCTGC AACTATGCCC CCGATGAGGA 2640
CCAAGGGCAC CTCCAGGACA GCTGGACCGC GTTGGAAGGT GCAGAGGATA AGGAGGCACT 2700
GCTGATTGAA GACACACTCA GCAACCACAC GGATCTGACA GACAATGATC CAGTCACCTA 2760
TGTGGTCCAG AAGCAGTTTA TGAGACAGCT GAGTGCCCTG TCCTCAGATG GGGAGGGACA 2820
GGGTCGGCCT GTACCCCGGA GGCACCTGGG TCCATCAGAG AAGGTGCAGG TGACAGAGGC 2880
GAAGGCAGAT GGGGCACTGA CCCACCAGGA GAAAGCAGCC ATTGGCACTG TGGAGCTCAG 2940
TGTGTTCTGG GATTATGCCA AGGCCGTGGG GCTCTGTACC ACGCTGGCCA TCTGTCTCCT 3000
GTATGTGGGT CAAAGTGCGG CTGCCATTGG AGCCAATGTG TGGCTCAGTG CCTGGACAAA 3060
TGATGCCATG GCAGACAGTA GACAGAACAA CACTTCCCTG AGGCTGGGCG TCTATGCTGC 3120
TTTAGGAATT CTGCAAGGGT TCTTGCTGAT GCTGGCAGCC ATGGCCATGG CAGCGGGTGG 3180
CATCCAGGCT GCCCGTGTGT TGCACCAGGC ACTGCTGCAC AACAAGATAC GCTCGCCACA 3240
GTCCTTCTTT GACACCACAC CATCAGGCCG CATCCTGAAC TGCTTCTCCA AGGACATCTA 3300
TGTCGTTGAT GAGGTTCTGG CCCCTGTCAT CCTCATGCTG CTCAATTCCT TCTTCAACGC 3360
CATCTCCACT CTTGTGGTCA TCATGGCCAG CACGCCGCTC TTCACTGTGG TCATCCTGCC 3420
CCTGGCTGTG CTCTACACCT TAGTGCAGCG CTTCTATGCA GCCACATCAC GGCAACTGAA 3480
GCGCCTGGAA TCAGTCAGCC GCTCACCTAT CTACTCCCAC TTTTCGGAGA CAGTGACTGG 3540
TGCCAGTGTC ATCCGGGCCT ACAACCGCAG CCGGGATTTT GAGATCATCA GTGATACTAA 3600
GGTGGATGCC AACCAGAGAA GCTGCTACCC CTACATCATC TCCAACCGGT GGCTGAGCAT 3660
CGGAGTGGAG TTCGTGGGGA ACTGCGTGGT GCTCTTTGCT GCACTATTTG CCGTCATCGG 3720
GAGGAGCAGC CTGAACCCGG GGCTGGTGGG CCTTTCTGTG TCCTACTCCT TGCAGGTGAC 3780
ATTTGCTCTG AACTGGATGA TACGAATGAT GTCAGATTTG GAATCTAACA TCGTGGCTGT 3840
GGAGAGGGTC AAGGAGTACT CCAAGACAGA GACAGAGGCG CCCTGGGTGG TGGAAGGCAG 900
CCGCCCTCCC GAAGGTTGGC CCCCACGTGG GGAGGTGGAG TTCCGGAATT ATTCTGTGCG 960
CTACCGGCCG GGCCTAGACC TGGTGCTGAG AGACCTGAGT CTGCATGTGC ACGGTGGCGA 4020
GAAGGTGGGG ATCGTGGGCC GCACTGGGGC TGGCAAGTCT TCCATGACCC TTTGCCTGTT 4080
CCGCATCCTG GAGGCGGCAA AGGGTGAAAT CCGCATTGAT GGCCTCAATG TGGCAGACAT 4140
CGGCCTCCAT GACCTGCGCT CTCAGCTGAC CATCATCCCG CAGGACCCCA TCCTGTTCTC 4200
CCGGACCCTG CGCATGAACC TGGACCCCTT CGGCAGCTAC TCAGAGGAGG ACATTTGGTG 4260
GGCTTTGGAG CTGTCCCACC TGCACACGTT TGTGAGCTCC CAGCCGGCAG GCCTGGACTT 4320
CCAGTGCTCA GAGGGCGGGG AGAATCTCAG CGTGGGCCAG AGGCAGCTCG TGTGCCTGGC 4380
CCGAGCCCTG CTCCGCAAGA GCCGCATCCT GGTTTTAGAC GAGGCCACAG CTGCCATCGA 4440
CCTGGAGACT GACAACCTCA TCCACCCTAC CATCCGCACC CAGTTTGATA CCTGCACTGT 4500
CCTGACCATC GCACACCGGC TTAACACTAT CATGGACTAC ACCAGGGTCC TGGTCCTGGA 4560
CAAAGGAGTA GTAGCTGAAT TTGATTCTCC AGCCAACCTC ATTGCAGCTA GAGGCATCTT 4620
CTACGGGATG GCCAGAGATG CTGGACTTGC CTAAAATATA TTCCTGAGAT TTCCTCCTGG 4680
CCTTTCCTGG TTTTCATCAG GAAGGAAATG ACACCAAATA TGTCCGCAGA ATGGACTTGA 4740
TAGCAAACAC TGGGGGCACC TTAAGATTTT GCACCTGTAA AGTGCCTTAC ACCGTAACTG 4800
TGCTGAATGC TTTAGATGAG GAAATGATCC CCAAGTGGTG AATGACACGC CTAAGGTCAC 4860
AGCTAGTTTG AGCCAGTTAG ACTAGTCCCC CGGTCTCCCG ATTCCCAACT GAGTGTTATT 4920
TGCACACTGC ACTGTTTTCA AATAACGATT TTATGAAATG ACCTCTGTCC TCCCTCTGAT 4980
TTTTCATATT TTCCTAAAGT TTCGTTTCTG TTTTTTAATA AAAAGCTTTT TCCTCCTGGA 5040
ACAGAAGACA GCTGCTGGGT CAGGCCACCC CTAGGAACTC AGTCCTGTAC TCTGGGGTGC 5100
TGCCTGAATC CATTAAAAAT GGGAGTACTG ATGAAATAAA ACTACATGGT CAACAGTAAA 5160
AAAAAAAAAA AAAAAA 5176
Seq ID NO: 127 DNA Sequence
Nucleic Acid Accession It: NM_002701 1
Coding sequence: 102..899
1 11 21 31 41 51
I I I I I I
GTAGTCCTTT GTTACATGCA TGAGTCAGTG AACAGGGAAT GGGTGAATGA CATTTGTGGG 60 TAGGTTATTT CTAGAAGTTA GGTGGGCAGC TCGGAAGGCA GATGCACTTC TACAGACTAT 120 TCCTTGGGGC CACACGTAGG TTCTTGAATC CCGAATGGAA AGGGGAGATT GATAACTGGT 180 GTGTTTATGT TCTTACAAGT CTTCTGCCTT TTAAAATCCA GTCCCAGGAC ATCAAAGCTC 240 TGCAGAAAGA ACTCGAGCAA TTTGCCAAGC TCCTGAAGCA GAAGAGGATC ACCCTGGGAT 300 ATACACAGGC CGATGTGGGG CTCACCCTGG GGGTTCTATT TGGGAAGGTA TTCAGCCAAA 360 CGACCATCTG CCGCTTTGAG GCTCTGCAGC TTAGCTTCAA GAACATGTGT AAGCTGCGCC 420 CCTTGCTGCA GAAGTGGGTG GAGGAAGCTG ACAACAATGA AAATCTTCAG GAGATATGCA 480 AAGCAGAAAC CCTCGTGCAG GCCCGAAAGA GAAAGCGAAC CAGTATCGAG AACCGAGTGA 540
GAGGCAACCT GGAGAATTTG TTCCTGCAGT GCCCGAAACC CACACTGCAG CAGATCAGCC 600
ACATCGCCCA GCAGCTTGGG CTCGAGAAGG ATGTGGTCCG AGTGTGGTTC TGTAACCGGC 660
GCCAGAAGGG CAAGCGATCA AGCAGCGACT ATGCACAACG AGAGGATTTT GAGGCTGCTG 720
GGTCTCCTTT CTCAGGGGGA CCAGTGTCCT TTCCTCTGGC CCCACCGCCC CATTTTGCTG 780
CCCCACCCTA TGGGAGCCCT CACTTCACTG CACTGTACTC CTCCCTCCCT TTCCCTGAGG 840
GGGAAGCCTT TCCCCCTGTC TCTGTCACCA CTCTGGGCTC TCCCTTGCAT TCAAACTGAG 900
GTGCCTGCCT GCCCTTCTAG GAATGGGGGA CAGGGGGAGG GGAGGAGCTA GGGAAAGAAA 960
ACCTCCAGTT TGTGCCAGGG TTTTTGGATT AAGTTCTTCA TTCACTAAGG AAGGAATTGG 1020
GAACACAAAG GGTGGGGGCA GGGGAGTTTG GGGCAACTGG TTGGAGGGAA GGTGAAGTTC 1080
AATGATGCTC TTGATTTTAA TCCCACATCA TGTATCACTT TTTTCTTAAA TAAAGAAGCT 1140
TGGGACACAG TAGATAGA 1158
Seq ID NO 128 DNA Sequence Nucleic Acid Accession tt Eos sequence
1 11 21 31 41 51
I I I I I I
AAATAAGTAT ATCTGTCAAA AATCATATTT TTATGAGATG TGTCAATACT GGTCTCGTGT 60
CATTTAGGCT ACTTGGAAAA AAGATAAAAA AAATCCTGTT TGGCTCCAAA AAGGAAAAAT 120
CAGCCCCTCC TGCATGAGTG GGAGCTGCAA CCCTTTAGAA CTGATAATCA CAAACCCCTC 180
AGAACCAAAG TGAAATGAAG GAAAATATGT AACATTAGGC ATTGATGGAA GAGGACTAGA 240
TCCTAGTGTA AGCATCCTAA TAAAAGGAGG GGTTCAAAGA TGCTCTCCAG AACCAGTATT 300
TCAGACTTCC TATGATAAAC TAAATGTGCC AGTACCAGAG ACTCCAGGAA AAACCAGAAA 360
TTTGTTTTTG CAATTAGCCG AGCATGTAGT CCAGTCTTTA AATGTCAATT CATGTTATGT 420
TTGTGGAAAA ACTGTAGTAA GAGTTTCCAT AAGAAGAACT TCCATAAGAA GCCCAAGAAT 480
TAGTTCCTAC AGACCCAGTT CCTGATGAAT TCCCAGCCCA AAAGAACCAC CCTGACAATT S40
TTTAGGTTCT AAAAGTCTGA ATTATTAGAC AGTATTGCAT AGCTAGAGAA GGAAAAGGAT 600
TCACTCATCC TATAAGGCGG CTTAGTTGTC TTAGGCAAAA GCTGTATAAT GGTACCACAA 660
ATACAGTTAC ATCCTGGAGT TCCAATTACA CAGAAAGAGA TCCATTCAGT CAATTTCCAA 720
GGTTGCAGAC TGCTTGGGCC CACCCAGAAT TCCACCGGGA CTGCACGCCC CCCACCAGGT 780
TATACTGGAT ATGTGGGCAC AGAGCTTATG CTAAGCTGCC TGATCAGTGG ACAGGTAGCT 840
GTGTAATTGA CACCATTAAA CCATCTTTCT TCTTACTGCC CATAAAAGCA GGGGAACTTC 900
TGGGCTTCCC AGTCTATGCT TCCCGCAAAA AACAAAGCAT AGCCATAGGT GATTGGAAAG 960
ATGATAAATG GCCCCCTGAA AGAATCATAC AATACTATGC ACCCACCACT TGGGCACAAG 1020
ATGACTCTTG GGGATATCGG ACCCCCATCT ACATGCTCAA CGGAATCATA CGGTTACAAG 1080
CTGTTTTCGA AATTATTACT AATACAACCG GTCAAGCCTT GACTGTTCTT GCCCAGCAGG 1140
AGACTCTGAT GAGAAATGCT ATCTATCAAA ATAGACTAGC TCTTGACTAC TTGCTAGCAG 1200
CTGAAAGAGA AGTTTGTGAA AAATTTAACT TTACTAATTG TTTTCTACAC ACAGGTGATC 1260
AAGGGCAAGT AGTTAAAAAT ATAGTTAAAG ATATAACAAA ACTGGCACAT GTACCCATAC 1320
AAGTGTGGCA CGGACTCAAT CCAGGATCCA TGTTTAAAAA TTAGTTCCCA GCAATAGGAA 1 80
GATTTAAAAC TCTTATAATA GGAGTTATAA TAGTAATAAA AACCTGCTTA CTGCTCCCTT 1440
GTTTACTACT TTTACTTCTA CAAATGATAA AAAGCTTCAT TGCTACCTTA GTTCACCAAA 1500
ATGCTTCAGC ACAAGTGTAC TATATGAATC ACTATCAATC TATTGCACAA AAAGACATAA 1S60
GTAGCAAAAA TAAGAGTGAG AACTCCCACT AATAAAAAGT GAGAGTCTCA AACCGGGAAA 1620
ATGAGGAAAG AGAGCGACCC TCTCATATTG TTCTATATTG TTTTATACTC AGTACCTGTT 1680
TTAAGGAAAA AACAACAAGG AAGTAAAATC AAAGACAGCC AGCCCAGCGC CAGGCCCAAA 1740
ACCAGGCCTG GGCCTGCCTG GCCTAAACCC AGTAGTTAAA AATCAACTCA TAACTTAGAA 1800
ACTGATGTTA TTCATAGATT CCAGACATTG TATAGAAGAA CATTGTGTAA CTCCCTGCCC 1860
TGTTCTGTTT CTCTCTGACT GCCGGTGCAT GCAGCCCCTG TCACGTACCG CCTGCTTGCT 1920
CAAATCAATC ACGACCCTTT CATGTGAAAT GTTTAGTGTT GTGAGCCCTT AAAAGGGACA 1980
GAAATCGTGC ACTCGGGGAG CTCAGATTTT AAGGCAGTAG TTTGCTGATG CTCCCAGCTG 2040
AATAAAGCCC TTCCTTCTAC AAAAAAAA 2068
Seq ID NO 129 DNA Sequence
Nucleic Acid Accession tt Eos sequence
1 11 21 31 41 51
I I I I I I
TTTTTTTTTT TTTTTTTTTT TTTCCTGTAA CACTTTATGT TTATTAGCAG TCTGGTTTTA 60
GCCTAAAAGT CACAACTTTT TTGGAAGTTT TCCCTAACCA GTCACCCCAG ATTAGGCACA 120
TGCCTCTAGG TTAGAGTCCT GTCACCAGAG ATTGATCACA CTTGATTGTG ATTGTTAGAC 180
AACTGTCTCA TTCAATAGAC TGTCAGTTTC TGGAGGCCAG AGATCTTGTC TCTGTTGTTC 240
CTCTTTTAAT CCCCAGTGTC TAGCATCTCA GAGACACTTG TTGAATGAAT TCATTAACGA 300
CTGGCTGAAT AATGAGCAAT TCATGAAAAA ACACTTTATA TTCACACCTT TTGGGTAAGA 360
CAGTAGCTCC CTTAAAACAC ACACACACTC TTCATGGTAT GTCACAGAAC TACAGTCTAC 420
ACTCAGTGCA AAGGGTTTCA AAATCCAGTA GGAAGGACAA ATATTGTCCC TCTTCTGTCC 480
TTGGAGAAGA TATTGTGCAA GTGTGGAGTT CTCCTGGAGA AATATTCTTT TTTTTTCTTT 540
GAGATGGAGT TTCACTCTTG TTGCCCAGGC TGGAGTGCAA TGGCACGATC TTAGCTCACT 600
GCAACCTCTG CCTCATGGGT TGAAGCAATT CAAGACCTGC CTTAGCCTCC TGGGTAGCTG 660
GAATTACAAG CACCCACCAC CACATCCAGC TAATTTTTTG TAATTTCAGT AGAGATGGGG 720
TTTCACTATA TTGGCCAGGC TGGTCTCGAA CTCCTGACTT CAGACAATCC ACCCGCCTCA 780
ATCTCCCAAA GTGCT 795
Seq ID NO 130 DNA Sequence
Nucle ic Acid Accession # NM_00 S458 1
Coding sequence 461 3286
1 11 21 31 41 SI
I I I I I I
GCCGCCCCTG AGCAGCCTCG CCTTCGCCTC CCGCGTTTCC TGCCGTCCGC CCTCCCCCGG 60
CCGAGCTCCA GGGGCTGCCG CCTAGCAGCT CCCGGCCCGA GAGCGGTTCA GAGCGCGCAC 120
GGGGGCGGGC GGAGGCGGCC CGGTGCCCGG CGGCCGCGCT GGAGAGAGGC GCGCGCGGAG 180
ACGCCGCCCC CCCTCTCCGC GTTTGCTCGC TTGCTCCCCG CCTCCCGCAC TCCGCTCGCT 240
CCCACCCCTT CCCCCCGTGA TTGATCCGTC ACGGGCGCCG CCGCTGCCGC CGCCGCCGCC 300
GCGGCCGTTC TGAGCCGAGC CGGAACCCTA GCCCGAGACG GAGCCGGGGC CCGGGCCGGC 360
GCCATTGCGC GGGCGCCGCG GGAAGACCTT GGCGCGGGGC GGCGGGCCGG GCCAGGCCAT 420 GCGGGCCGAG TGAGCCGGCG CCCGCAGCCC GCGGCGCGGC ATGGCTTCCC CGCGGAGCTC 480
CGGGCAGCCC GGGCCGCCGC CGCCGCCGCC ACCGCCGCCC GCGCGCCTGC TACTGCTACT S40
GCTGCTGCCG CTGCTGCTGC CTCTGGCGCC CCCGGCCTGC GGCTGGGCGC GGGGCGCCCC 600
CCGGCCGCCG CCCAGCAGCC CGCCGCTCTC CATCATGGGC CTCATGCCGC TCACCAAGGA 660
GGTGGCCAAG GGCAGCATCG GGCGCGGTGT GCTCCCCGCC GTGGAACTGG CCATCGAGCA 720
GATCCGCAAC GAGTCACTCC TGCGCCCCTA CTTCCTCGAC CTGCGGCTCT ATGACACGGA 780
GTGCGACAAC GCAAAAGGGT TGAAAGCCTT CTACGATGCA ATAAAATACG GGCCTAACCA 840
CTTGATGGTG TTTGGAGGCG TCTGTCCATC CGTCACATCC ATCATTGCAG AGTCCCTCCA 900
AGGCTGGAAT CTGGTGCAGC TTTCTTTTGC TGCAACCACG CCTGTTCTAG CCGATAAGAA 960
AAAATACCCT TATTTCTTTC GGACCGTCCC ATCAGACAAT GCGGTGAATC CAGCCATTCT 1020
GAAGTTGCTC AAGCACTACC AGTGGAAGCG CGTGGGCACG CTGACGCAAG ACGTTCAGAG 1080
GTTCTCTGAG GTGCGCAATG ACCTGACTGG AGTTCTGTAT GGCGAGGACA TTGAGATTTC 1140
AGACACCGAG AGCTTCTCCA ACGATCCCTG TACCAGTGTC AAAAAGCTGA AGGGGAATGA 1200
TGTGCGGATC ATCCTTGGCC AGTTTGACCA GAATATGGCA GCAAAAGTGT TCTGTTGTGC 1260
ATACGAGGAG AACATGTATG GTAGTAAATA TCAGTGGATC ATTCCGGGCT GGTACGAGCC 1320
TTCTTGGTGG GAGCAGGTGC ACACCCAAGC CAACTCATCC CGCTGCCTCC GGAAGAATCT 1380
GCTTGCTGCC ATGGAGGGCT ACATTGGCGT GGATTTCGAG CCCCTGAGCT CCAAGCAGAT 1440
CAAGACCATC TCAGGAAAGA CTCCACAGCA GTATGAGAGA GAGTACAACA ACAAGCGGTC 1500
AGCCGTGGGG CCCAGCAAGT TCCACCCGTA CGCCTACGAT GGCATCTCCG TCATCGCCAA 1560
GACACTGCAG AGGGCCATGG AGACACTGCA TGCCAGCAGC CCCCACCAGC GGATCCAGGA 1620
CTTCAACTAC ACGGACCACA CGCTGGGCAG GATCATCCTC AATGCCATGA ACGAGACCAA 1680
CTTCTTCGGG GTCACGGGTC AAGTTGTATT CCGGAATGGG GAGAGAATGG GGACCATTAA 1740
ATTTACTCAA TTTCAAGACA GCAGGGAGGT GAAGGTGGGA GAGTACAACG CTGTGGCCGA 1800
CACACTGGAG ATCATCAATG ACACCATCAG GTTCCAAGGA TCCGAACCAC CAAAAGACAA 1860
GACCATCATC CTGGAGCAGC TGCGCAAGAT CTCCCTACCT CTCTACAGCA TCCTCTCTGC 1920
CCTCACCATC CTCCCGATGA TCATGGCCAG TGCTTTTCTC TTCTTCAACA TCAAGAACCG 1980
GAATCAGAAG CTCATAAAGA TGTCGAGTCC ATACATGAAC AACCTTATCA TCCTTGGAGG 2040
GATGCTCTCC TATGCTTCCA TATTTCTCTT TGGCCTTGAT GGATCCTTTG TCTCTGAAAA 2100
GACCTTTGAA ACACTTTGCA CCGTCAGGAC CTGGATTCTC ACCGTGGGCT ACACGACCGC 2160
TTTTGGGGCC ATGTTTGCAA AGACCTGGAG AGTCCACGCC ATCTTCAAAA ATGTGAAAAT 2220
GAAGAAGAAG ATCATCAAGG ACCAGAAACT GCTTGTGATC GTGGGGGGCA TGCTGCTGAT 2280
CGACCTGTGT ATCCTGATCT GCTGGCAGGC TGTGGACCCC CTGCGAAGGA CAGTGGAGAA 2340
GTACAGCATG GAGCCGGACC CAGCAGGACG GGATATCTCC ATCCGCCCTC TCCTGGAGCA 2400
CTGTGAGAAC ACCCATATGA CCATCTGGCT TGGCATCGTC TATGCCTACA AGGGACTTCT 2460
CATGTTGTTC GGTTGTTTCT TAGCTTG GA GACCCGCAAC GTCAGCATCC CCGCACTCAA 2520
CGACAGCAAG TACATCGGGA TGAGTGTCTA CAACGTGGGG ATCATGTGCA TCATCGGGGC 2580
CGCTGTCTCC TTCCTGACCC GGGACCAGCC CAATGTGCAG TTCTGCATCG TGGCTCTGGT 2640
CATCATCTTC TGCAGCACCA TCACCCTCTG CCTGGTATTC GTGCCGAAGC TCATCACCCT 2700
GAGAACAAAC CCAGATGCAG CAACGCAGAA CAGGCGATTC CAGTTCACTC AGAATCAGAA 2760
GAAAGAAGAT TCTAAAACGT CCACCTCGGT CACCAGTGTG AACCAAGCCA GCACATCCCG 2820
CCTGGAGGGC CTACAGTCAG AAAACCATCG CCTGCGAATG AAGATCACAG AGCTGGATAA 2880
AGACTTGGAA GAGGTCACCA TGCAGCTGCA GGACACACCA GAAAAGACCA CCTACATTAA 2940
ACAGAACCAC TACCAAGAGC TCAATGACAT CCTCAACCTG GGAAACTTCA CTGAGAGCAC 3000
AGATGGAGGA AAGGCCATTT TAAAAAATCA CCTCGATCAA AATCCCCAGC TACAGTGGAA 3060
CACAACAGAG CCCTCTCGAA CATGCAAAGA TCCTATAGAA GATATAAACT CTCCAGAACA 3120
CATCCAGCGT CGGCTGTCCC TCCAGCTCCC CATCCTCCAC CACGCCTACC TCCCATCCAT 3180
CGGAGGCGTG GACGCCAGCT GTGTCAGCCC CTGCGTCAGC CCCACCGCCA GCCCCCGCCA 3240
CAGACATGTG CCACCCTCCT TCCGAGTCAT GGTCTCGGGC CTGTAAGGGT GGGAGGCCTG 3300
GGCCCGGGGC CTCCCCCGTG ACAGAACCAC ACTGGGCAGA GGGGTCTGCT GCAGAAACAC 3360
TGTCGGCTCT GGCTGCGGAG AAGCTGGGCA CCATGGCTGG CCTCTCAGGA CCACTCGGAT 3420
GGCACTCAGG TGGACAGGAC GGGGCAGGGG GAGACTTGGC ACCTGACCTC GAGCCTTATT 3480
TGTGAAGTCC TTATTTCTTC ACAAAGAAGA GGAACGGAAA TGGGACGTCT TCCTTAACAT 3540
CTGCAAACAA GGAGGCGCTG GGATATCAAA CTTGCAAAAA AAAAAAAAAA AAAAAAAAAA 3600
CAAAAAAACT AGACAAGGAG AGAGGCACTA GAACTCCAGC TGGAAGTCAC GGAGTGGCTC 3660
GAGCAGCCTT GGGAAGAGGC AAGGAGCTTC TGAAGAAACT GCCTCTGCAC ACACATCACT 3720
GGCTGTGACC CCTCAGGCTA GCCCTTCTCC ACTCTGGGGG AGGAGGTGGG AAGGGCCACC 3780
AGGCCCCCAG CTGCCAGGCC AGCTGACCCC AGCCTTCCTG GAACAGGGAG TCTGCACCAG 3840
CGCAGACAGG CACAGCCCTG GAGCAGGCAG GCCGAGGGCT GCGGCACTGC AGCAGGCTGA 3900
CTTACATGCT CCACATGGGA CCTGTGTCAC CCAATGAGAT GTTTGTTACT CTGGTAAATG 3960
CCACACGTTA ACACAATAAC ACCCATTCCT GGGACCGTGG GGATTTAGGG CACGTCACTG 4020
CAGACACGCT CTGCAGCATT CACCGACAGT CTGTCATGCA CCCACCACGT TGGCCATGTC 4080
CTTGTGTTCC TATCGGATGC TCCCAGTAAC CAGGGGGACC ACCCGAGCTA ATCATGGAAT 4140
GTCTGTTCCC AGCAAACACG ATAAAGAAAG ATTGTGCACT TTAACCTCTC TCATCAGGGC 4200
CCAAGGGCTG GCTGGGATTT TTTTTTTTTT TTTCCCACTA ACTTTGTTTC TGACCAAAGT 4260
GAATTGGAGG CACTCTGCTA AAAGACATCC CCGTAGACAT AGGGGAGAGA GTTGCTGGCT 4320
GAGGGCTTCC CTTGGCTTCC AGAAGGCAGC CTTCCATCCA GACAAGCCAG TGAGCTCTCC 4380
CCTTGGGATC ACTGGGGTGA TCAGTCAGCA GATTGATTCT CATTCATAAG ATCATTCCTC 4440
CCTTTAAATT GAGCCCCTAA GAGCACTGGC CTGGGAGTCA GACAGACCTG GGTTCAAGTC 4500
CTCAGTCCCC TGCCCACTCC CTACGTGACT TTGATCAGGT CACTAGTGTC TCTCTGAGCC 4560
TCAGTTTCCC CTCTGTAACT TGGGGTTGAA CTAAAACACC TGTCCTGCCT ACCTCACAAG 4620
GTCACTCTGA GGATTGAAAC TTGATCTTGT CCAGGAAAGC TTTGTACCAA ACAGTGAAGC 4680
CGCCCTGATC CGTGAGGTAT GAGTATGACT CTGACCTTCA GCCCTCCCTA CAGCCGGGGG 4740
TGTGGCCCAG AGAAGCTTCC AGCACAGCCC TCTACCCAGA ACATCCGGGC TGGAGGGAGG 4800
CTCCCAGTGA CTTTTCTGAC ATTCCTAGAC AGGTTCATTC TTTGCTCAAG AAAGGCCTGA 4860
ATGACAATGT CCAGGATGTC TGCACAACTG AGCAGCTCGC TCACTCCCTA AAGAAACCTA 4920
TTGGCAGCTT CAACAGGCAG GCAATAATCT CTTCCCAGAA CCACTGCAGT CAGGAATAAA 4980
CTGTTTTCTC CACCAGGCTT TGACAAAAGG GCCCACAGGA ATCTTACCAA TGCCAACATT 5040
TCAAAGCACC CTATTTCACG TAGCATAGCT TTCTGCTCCC CTTCCCCAAA GAGAGGTTAT 5100
GGAGGTACTG TAGCTTTTAG GGAAAAAAAA ATGTTAACAC ATCACAGGTC AAGTTGAAGT 5160
CATTCTCTGT TTAGGCACTA AAAATCGGTG TTGTCACTCA CTGTGTATTA CCAGTATTTA 5220
CTTGCTTTCT TGATTTCACC AAAACCAAAT TTAATTTAAA GGACCACATT AATTTTTCAA 5280
AGGGAAAGAG ACAATTAATT GTACATAATG TATACACACA CACAAAAAAA AATACCTGTA 5340
GAAATATTAT TCCAGCATAG CAGGAAAACA AACAAAAGTA TTGGACTGTC GGAGGTGAGC 5400
CTGTGCGTCT GTAACCCTTT GTGACTCCTG AGCGTGCGCT GTCTTCTACC TTAACTCACG 5460 AAGTACATTC TCTGTCTTAC TGATACTGTA GGTTCACCCA TTTTTTTTTA ATTTCCTCGC 5520
AAATAACAAG ACCCACAGAA GTGACTCTAG CTACTTAATG GTTCTGTTCT TTTATATGCA 5580
GCAAACACAC CGTCCATTTC TGAAGAGGCT TCGGCCTGAA GGCATTTTCC AATGATGTTA 5640
GTGCACAAAA CGCTTTAAAT TAGACTGGAA CTGCCAGAAT CAAATGTAAA TGAGGAATTT 5700
CTCGTACCCC TACTGCATGG TATCGATTTT TAATAAATTG TTGCAAATTT GTTTTTATGA 5760
ATAAAAGGAA AAAACCTGTC GTCTTT 5786
Seq ID NO 131 DNA Sequence
Nucleic Acid Accession tt NM_014817
Coding sequence 247 2682
1 11 21 31 41 51
I I I I I I
CAGAAATGCA ACAAGTAGTA CCCGGGGTCT GCAGAGCGCC CCGCGCCGCC TGACTTGGCC 60
GGGCGAAGCC CGCCTGCAGA GACCCGGGCC GGCCTCCGGA CAAAGGACGG AGGAGGGGCT 120
GGACGGCGCT GCGAAGTCCG AAAGAGGCCA TTTAGCGACT CTGGCCAGGC TAAGGGGAAT 180
GCAGAGGAGA CACAGAGCCG GCGGGCCAAG AGGACGATCC GGCCGCTGCA CGCAGGGCGG 240
GAGGCGATGG AGGCTGCCCG CGCCTTGCGC CTCCTGCTCG TGGTGTGCGG CTGCCTCGCG 300
CTCCCGCCGC TGGCCGAGCC CGTGTGCCCG GAGCGCTGCG ACTGCCAGCA TCCCCAGCAT 360
CTCCTGTGCA CCAACAGGGG GCTCCGCGTA GTGCCCAAGA CCAGCTCGCT GCCGAGCCCC 420
CACGACGTGC TCACCTACAG CCTCGGCCCC AACTTCATAA CCAACATCAC GGCCTTCGAC 480
TTCCACCGTC TGGGGCAGCT CAGACGGCTG GACCTGCAGT ACAACCAGAT CCGCTCTCTG 540
CACCCCAAGA CCTTCGAGAA GCTCTCGCGG CTGGAAGAGC TGTACCTGGG GAACAACCTC 600
TTGCAGGCGC TCGCCCCGGG CACGCTGGCC CCGCTGCGCA AGCTGCGCAT CCTCTACGCC 660
AACGGCAACG AGATCAGCCG CCTAAGCCGC GGCTCCTTCG AGGGCCTGGA GAGTCTAGTC 720
AAGCTGCGGC TGGACGGGAA CGCCCTGGGG GCGCTGCCGG ACGCGGTCTT CGCTCCCTTG 780
GGCAACCTGC TCTACCTACA TCTGGAGTCC AACCCCATCC GCTTTCTGCG CAAGAACGCC 840
TTCGCCCAGC TAGGCAAGCT GCGCTTCCTC AACCTCTCTG CCAACGAGCT ACAGCCCTCC 900
CTGCGCCACG CGGCCACCTT CGCACCGCTG CGCTCCCTCT CCTCCCTCAT CCTCTCGGCC 960
AACAGCCTGC AGCACCTCGG GCCGCGCATC TTCCAGCACC TGCCACGTCT CGGCCTGCTC 1020
TCGCTCAGGG GCAACCAGCT CACGCACCTC GCGCCTGAGG CCTTTTGGGG CTTCCAGGCC 1080
CTGCGCGAGC TGCGCCTGGA GGGTAATCGG CTGAGCCAGC TGCCAACTGC GCTGCTGGAG 1140
CCTCTGCACA GCCTGGAGGC GCTGGACCTG AGCGGCAATG AGCTGTCCGC CCTGCACCCG 1200
GCCACCTTCG GCCACCTGGG CCGGCTGCGC GAGCTCAGCC TGCGCAACAA CGCGCTCAGC 1260
GCCCTATCCG GGGACATCTT CGCCGCCAGC CCAGCCCTTT ATCGGCTGGA TCTAGACGGC 1320
AACGGCTGGA CCTGCGACTG CCGGCTGCGA GGCCTGAAGC GCTGGATGGG CGACTGGCAC 1380
TCGCAGGGCC GGCTCCTCAC TGTCTTCGTG CAGTGTCGCC ACCCCCCGGC CCTGCGAGGC 1440
AAATACCTGG ATTACCTGGA TGACCAGCAG CTGCAAAATG GATCCTGCGC GGATCCCTCG 1500
CCCTCAGCTT CCCTGACCGC TGACCGCAGG CCCCAGCCCC TACCCACGGC CGCAGGGGAG 1560
GAGATGACGC CACCTGCAGC TCTCGCGGAG GAGCTGCCGC CGCAGCCGCA GCTCCAGCAG 1620
CACCGGCGAT TTCTAGCTGG GGTGGCCTGG GATGGGGCCG CCAGGGAGCT GGTAGGCAAC 1680
CGCAGCGCTC TAAGGCTGAG TCCCCGGGGC CCGGGCCTCC AGCAGCCCAG CCCCTCCGTC 1740
GCTGCCGCCG CGGCCCCGCC TCCACAGTCC CTAGACCTGC ACAAGAAGCC CCAGCGGGGC 1800
CGTCCGACTC GGGCAGATCC CGCCCTCGCG GAGCCCACCC CAACGGCCTC TCCTGGCTCT 1860
GCGCCATCGC CCGCCGGCGA CCCCTGGCAG CGCGCGACGA AGCATCGTCT GGGCACGGAG 1920
CACCAGGAGC GTGCCGCCCA GTCCGACGGT GGGGCCGCCC TGCCGCCGCT GGTGTCCGAC 1980
CCATGCGACT TCAACAAGTT CATTCTGTGC AACCTGACGG TGGAGGCGGT GGGCGCAGAC 2040
AGCGCCTCGG TGCGCTGGGC CGTGCGCGAG CACCGCAGTC CCCGGCCGCT GGGCGGCGCG 2100
CGCTTCCGCC TGCTCTTTGA CCGCTTTGGC CAGCAGCCCA AGTTCCACCG CTTCGTCTAC 2160
CTGCCTGAGA GCAGCGACTC GGCCACGCTG CGCGAGCTGC GCGGGGACAC CCCCTACCTG 2220
, GTGTGCGTGG AGGGCGTGCT TGGGGGCCGT GTCTGCCCTG TGGCTCCCCG GGACCACTGC 2280
GCGGGGCTGG TCACCCTACC GGAGGCCGGG AGCCGCGGCG GCGTCGACTA CCAGCTGCTG 2340
ACCTTGGCCC TGCTGACGGT CAACGCGCTG CTGGTGCTCC TGGCCTTGGC GGCCTGGGCG 2400
TCTCGCTGGC TGCGTAGGAA ACTGCGGGCT AGGCGGAAGG GCGGGGCCCC GGTCCACGTT 2460
CGGCACATGT ACTCCACCCG ACGGCCCCTG CGCTCCATGG GCACCGGCGT GTCCGCCGAC 2520
TTCTCGGGAT TCCAGTCGCA CCGGCCACGC ACCACCGTGT GCGCGCTCAG TGAGGCGGAC 2580
CTCATCGAAT TCCCCTGCGA CCGCTTCATG GACAGTGCGG GCGGCGGCGC GGGCGGCAGC 2640
CTGAGACGGG AGGACCGTCT CCTGCAGCGA TTTGCCGACT AGGTCCAGGG CATATAGAGA 2700
CCATCTCATT GGCCCTAAGG AGCCGCCTCT CCGTGAGGCC CACCAGCCCA CCTCACCGGA 2760
AGTGCCGTTT TGTGCACTTG CCAGAGAGGC CGGTGGGGAC AGAGGGCCAA TTCGGGCACC 2820
ATCCCCCAAT TCCCAATACT CGAGAAGTAA ATGGATGGTA CTTGGTGGTC AGAGCCAGAG 2880
TAGGGGACAA ATGGATGGTG GGATGCTGAG GTCGGAGGCT TCGCTTGGAG GCTTTGACAC 2940
AGCTATGCGA ATGGCTTTTG TAGCACTGCA ATGCAGAAGC CAGGCTTTGG GGGTAGAAAG 3000
GGGGTGCTTG TGCCCCCAAC ATGGCCAGAA ATATTTGGGT GCATGCTTTT TGTTTGCTCA 3060
GTGTCAAACA GAGAAGTTTT GTTTCTATTT AAGGAAGGAA CTTATTACCA TTACAAAGGA 3120
GGCTTGGCCA GGGACTCCAC TGGTTTGGTG ATCTCTGCCA AGAAGGGGGA TGTAAACAGG 3180
TGGTAAAGTT TAACATACCC GCCAAGGAAC TCGTTTATGT TGGCTGATAG AGCATTCAGG 3240
ATACCTTAAA GTTTAATAAG AGACGCATTT TTTTTTTTCA AAAATGTGAA AAGCTCTGAC 3300
ATTTAACGAA CTGACCAATA GACTCAAGGA CTGTTTTAGT TGGACTGGGC CATTTTATTA 3360
TGTTCCTTTT AATATTAACA GTACAAGAGC GCTTGCTGAC TTCGAGGATA ACTAAGATTA 3420
CATACTTTCT CAGGAGAAGG CTGCATGCAA GACTTCTCTG TCAGGGTTGC TCCTGTGGCT 3480
TTTTTAATTT TATTTTTTTA AACCTATATA TGGAAAAGGA AATTTCAATG CCAGATTTGA 3540
TAAAAGAATG TGATGTATAT GTAGCTGATG ACCCACTGCG GAACACCAGT GTTCCAGTTC 3600
ACTTACCACA TCTGTGACAG TGTGTTTAGA TTGGAATAAA TGTGATGCAT TACTTCTTAT 3660
GTTTTTATCA GTGACATGGT TGACTGTGCC CTAATTCTCT TGAGTTGCAG TTAAGCAATG 3720
AAGGTTATTT CCTAATAGGG AAGCAAAAGG TGATTGTCAA TTGATAGTTT AATGTTTGAC 3780
CACATTAGTG TCTTTATATG AAATAGTAGA GGGGAAGAAA TTATAGAAAA CAAATGTGAA 3840
AAAAATACAC CAGTGGGTAT CTGTTCTACT AAAACCAGAA GATTGTTATG AGTACTTAAA 3900
CCTCACTGTG AAATAATGAT ATATTTTGCA ATTAATCCCT CCCCAACTGA GTGTCTTACT 3960
GTGTTATTAA ATCTTATCTT TTAGTTAATA GTTGCAGTAT TTCTTTTAAA TGTTTTTGTT 4020
TTAAACTTAG GGGTAGGATC CTTTATTTGT TCAGTTGTTT CCAACTATTT CCGATACTTT 4080
CATTCCCTGC TATTTATGAA GTACATGTTT ATCACTAAGT GTAGTGGTTT GGTTTACATT 4140
AATAATTTTA TGTGTGGTCT AAAAATGCAG TCACTAAGAG AATGTACACT GTGGTTATGG 4200
TCACAGTGGT TATGGATTTA TTGGCAGTGG AGTACCATGG AGGTCACTGC AATGGTGCTA 4260
AGGCTGACAG TGGAATCTTC TGTTTAGGGC CTTAAGCCCC TGAGGGTCCT GGTGACTCAG 4320 GGAATCCATC ACAGCCCCGG GTCTTTCACC CCAGTTCACT CCTTTTATGT TTGGCCTAGA 4380
TTGACCCATG CCTGCCCTCT TCTCAACAGC TGAGTAGGGA ACCAGCCATC TGAATGAGCT 4440
GATCGTTGTT TATGTTCAAA TGAGTAAATG TCCAGACCAC TTAAAACTAC AGCTGCTTTT 4500
CTGGCAGTCT CGTCTGCGGG GCCAAAACTT AATAAACCAC AGGAAATAGA CTGTCATTCT 4560
TAGTTTGCTG CCACCGCTTA TTTTAGATTG AGAGCATACT GGTACATGAG AGCAGTAGTG 4620
TTGTTTGCTC TTATTTTCAA CCAGGGAGCT ATCTGGCACC TTTTGTGCTC CTGGCTTTTT 4680
TCAATCATAG CACTATTGCA TCTCCTAGCT ATTTCTTTTG CCCAGCAGGG TAATATTGAG 4740
TCCCATTGCA AGTATGGACA AGGCCTCTGG TTCTCCTCAC CACCCACCTT TTCAGCCATA 4800
GAACATCACT GAAAATGCCT AATGCCTGGA TCTGTGTTCT ACTTTAGTTT CACTGGGAAG 4860
TCTTTCAGTG GGAGATGAAT AAATGTTATA CATTGTTATG TCCAGTTATG TCAATAAACC 4920
CACTAATAGA GAT 4933
Seq ID NO : 132 DNA Sequence
Nucleic Acid Accession tt : NM_001792 . 2
Coding sequence : 206 . . 2926
1 11 21 31 41 51
I I I I I I
TTTGTCATCA GCTCGCTCTC CATTGGCGGG GAGCGGAGAG CAGCGAAGAA GGGGGTGGGG 60
AGGGGAGGGG AAGGGAAGGG GGTGGAAACT GCCTGGAGCC GTTTCTCCGC GCCGCTGTTG 120
GTGCTGCCGC TGCCTCCTCC TCCTCCGCCG CCGCCGCCGC CGCCGCCGCC TCCTCCGGCT 180
CTTCGCTCGG CCCCTCTCCG CCTCCATGTG CCGGATAGCG GGAGCGCTGC GGACCCTGCT 240
GCCGCTGCTG GCGGCCCTGC TTCAGCCGTC TGTAGAGGCT TCTGGTGAAA TCGCATTATG 300
CAAGACTGGA TTTCCTGAAG ATGTTTACAG TGCAGTCTTA TCGAAGGATG TGCATGAAGG 360
ACAGCCTCTT CTCAATGTGA AGTTTAGCAA CTGCAATGGA AAAAGAAAAG TACAATATGA 420
GAGCAGTGAG CCTGCAGATT TTAAGGTGGA TGAAGATGGC ATGGTGTATG CCGTGAGAAG 480
CTTTCCACTC TCTTCTGAGC ATGCCAAGTT CCTGATATAT GCCCAAGACA AAGAGACCCA 540
GGAAAAGTGG CAAGTGGCAG TAAAATTGAG CCTGAAGCCA ACCTTAACTG AGGAGTCAGT 600
GAAGGAGTCA GCAGAAGTTG AAGAAATAGT GTTCCCAAGA CAATTCAGTA AGCACAGTGG 660
CCACCTACAA AGGCAGAAGA GAGACTGGGT CATCCCTCCA ATCAACTTGC CAGAAAACTC 720
CAGGGGACCT TTTCCTCAAG AGCTTGTCAG GATCAGGTCT GATAGAGATA AAAACCTTTC 780
ACTGCGGTAC AGTGTAACTG GGCCAGCAGC TGACCAGCCT CCAACTGGTA TCTTCATTAT 840
CAACCCCATC TCGGGTCAGC TGTCGGTGAC AAAGCCCCTG GATCGCGAGC AGATAGCCCG 900
GTTTCATTTG AGGGCACATG CAGTAGATAT TAATGGAAAT CAAGTGCAGA ACCCCATTGA 960
CATTGTCATC AATGTTATTG ACATGAATGA CAACAGACCT GAGTTCTTAC ACCAGGTTTG 1020
GAATGGGACA GTTCCTGAGG GATCAAAGCC TGGAACATAT GTGATGACCG TAACAGCAAT 1080
TGATGCTGAC GATCCCAATG CCCTCAATCC GATGTTGAGG TACAGAATCG TGTCTCAGGC 1140
TCCAAGCACC CCTTCACCCA ACATGTTTAC AATCAACAAT GAGACTGGTG ACATCATCAC 1200
AGTGGCAGCT GGACTTGATC GAGAAAAAGT GCAACAGTAT ACGTTAATAA TTCAAGCTAC 1260
AGACATGGAA GGCAATCCCA CATATGGCCT TTCAAACACA GCCACGGCCG TCATCACAGT 1320
GACAGATGTC AATGACAATC CTCCAGAGTT TACTGCCATG ACGTTTTATG GTGAAGTTCC 1380
TGAGAACAGG GTAGACATCA TAGTAGCTAA TCTAACTGTG ACCGATAAGG ATCAACCCCA 1440
TACACCAGCC TGGAACGCAG TGTACAGAAT CAGTGGCCCA GATCCTACTG GACGGTTCGC 1500
CATCCAGACC GACCCAAACA GCAACGACGG GTTAGTCACC GTGGTCAAAC CAATCGACTT 1560
TGAAACAAAT AGGATGTTTG TCCTTACTGT TGCTGCAGAA AATCAAGTGC CATTAGCCAA 1620
GGGAATTCAG CACCCGCCTC AGTCAACTGC AACCGTGTCT GTTACAGTTA TTGACGTAAA 1680
TGAAAACCCT TATTTTGCCC CCAATCCTAA GATCATTCGC CAAGAAGAAG GGCTTCATGC 1740
CGGTACCATG TTGACAACAT TCACTGCTCA GGACCCAGAT CGATATATGC AGCAAAATAT 1800
TAGATACACT AAATTATCTG ATCCTGCCAA TTGGCTAAAA ATAGATCCTG TGAATGGACA 1860
AATAACTACA ATTGCTGTTT TGGACCGAGA ATCACCAAAT GTGAAAAACA ATATATATAA 1920
TGCTACTTTC CTTGCTTCTG ACAATGGAAT TCCTCCTATG AGTGGAACAG GAACGCTGCA 1980
GATCTATTTA CTTGATATTA ATGACAATGC CCCTCAAGTG TTACCTCAAG AGGCAGAGAC 2040
TTGCGAAACT CCAGACCCCA ATTCAATTAA TATTACAGCA CTTGATTATG ACATTGATCC 2100
AAATGCTGGA CCATTTGCTT TTGATCTTCC TTTATCTCCA GTGACTATTA AGAGAAATTG 2160
GACCATCACT CGGCTTAATG GTGATTTTGC TCAGCTTAAT TTAAAGATAA AATTTCTTGA 2220
AGCTGGTATC TATGAAGTTC CCATCATAAT CACAGATTCG GGTAATCCTC CCAAATCAAA 2280
TATTTCCATC CTGCGCGTGA AGGTTTGCCA GTGTGACTCC AACGGGGACT GCACAGATGT 2340
GGACAGGATT GTGGGTGCGG GGCTTGGCAC CGGTGCCATC ATTGCCATCC TGCTCTGCAT 2400
CATCATCCTG CTTATCCTTG TGCTGATGTT TGTGGTATGG ATGAAACGCC GGGATAAAGA 2460
ACGCCAGGCC AAACAACTTT TAATTGATCC AGAAGATGAT GTAAGAGATA ATATTTTAAA 2520
ATATGATGAA GAAGGTGGAG GAGAAGAAGA CCAGGACTAT GACTTGAGCC AGCTGCAGCA 2580
GCCTGACACT GTGGAGCCTG ATGCCATCAA GCCTGTGGGA ATCCGACGAA TGGATGAAAG 2640
ACCCATCCAC GCTGAGCCCC AGTATCCGGT CCGATCTGCA GCCCCACACC CTCCAGACAT 2700
TGGGGACTTC ATTAATGAGG GCCTTAAAGC GGCTGACAAT GACCCCACAG CTCCACCATA 2760
TGACTCCCTG TTAGTGTTTG ACTATGAAGG CAGTGGCTCC ACTGCTGGGT CCTTGAGCTC 2820
CCTTAATTCC TCAAGTAGTG GTGGTGAGCA GGACTATGAT TACCTGAACG ACTGGGGGCC 2880
ACGGTTCAAG AAACTTGCTG ACATGTATGG TGGAGGTGAT GACTGAACTT CAGGGTGAAC 2940 TTGGTTTTTG GACAAGTACA AACAATTTCA ACTGATATTC CCAAAAAGCA TTCAGAAGCT 3000 AGGCTTTAAC TTTGTAGTCT ACTAGCACAG TGCTTGCTGC AGGCTTTGGC ATAGGCTGCA 3060 AACCAATTTG GGCTCAGAGG GAATATCAGT GATCCATACT GTTTGGAAAA ACACTGAGCT 3120 CAGTTACACT TGAATTTTAC AGTACAGAAG CACTGGGATT TTATGTGCCT TTTTGTACCT 3180 TTTTCAGATT GGAATTAGTT TTCTGTTTAA GGCTTTAATG GTACTGATTT CTGAAACGAT 3240 AAGTAAAAGA CAAAATATTT TGTGGTGGGA GCAGTAAGTT AAACCATGAT ATGCTTCAAC 3300 ACGCTTTTGT TACATTGCAT TTGCTTTTAT TAAAATACAA AATTAAACAA ACAAAAAAAC 3360 TCATGGAGCG ATTTTATTAT CTTGGGGGAT GAGACCATGA GATTGGAAAA TGTACATTAC 3420 TTCTAGTTTT AGACTTTAGT TTGTTTTTTT TTTTTCACTA AAATCTTAAA ACTTACTCAG 3480 CTGGTTGCAA ATAAAGGGAG TTTTCATATC ACCAATTTGT AGCAAAATTG AATTTTTTCA 3540 TAAACTAGAA TGTTAGACAC ATTTTGGTCT TAATCCATGT ACACTTTTTT ATTTCTGTAT 3600 TTTTCCACTT CACTGTAAAA ATAGTATGTG TACATAATGT TTTATTGGCA TAGTCTATGG 3660 AGAAGTGCAG AAACTTCAGA ACATGTGTAT GTATTATTTG GACTATGGAT TCAGGTTTTT 3720 TGCATGTTTA TATCTTTCGT TATGGATAAA GTATTTACAA AACAGTGACA TTTGATTCAA 3780 TTGTTGAGCT GTAGTTAGAA TACTCAATTT TTAATTTTTT TAATTTTTTT ATTTTTTATT 3840 TTCTTTTTCC TTTGGGGAGG GAGAAAAGTT CTTAGCACAA ATGTTTTACA TAATTTGTAC 3900 CAAAAAAAAA AAAAAGGAAA GGAAAGAAAG GGGTGGCCTG ACACTGGTGG CACTACTAAG 3960 TGTGTGTTTT TTAAAAAAAA AAATGGAAAA AAAAAAGCTT TTAAACTGGA GAGACTTCTG 4020 ACAACAGCTT TGCCTCTGTA TTGTGTACCA GAATATAAAT GATACACCTC TGACCCCAGC 4080
GTTCTGAATA AAATGCTAAT TTTGCAAAAA AAAAAAAAAA AA 4122
Seq ID NO 133 DNA Sequence
Nucleic Acid Accession # NM_016941 1
Coding sequence 8 1864
1 11 21 31 41 51
I I I I I I
GAAGGCCATG GTCTCCCCAC GGATGTCCGG GCTCCTCTCC CAGACTGTGA TCCTAGCGCT 60
CATTTTCCTC CCCCAGACAC GGCCCGCTGG CGTCTTCGAG CTGCAGATCC ACTCTTTCGG 120
GCCCCGTCCA GGCCCTGGGG CCCCGCGGTC CCCCTGCAGC GCCCCCCTCC CCTGCCGCCT 180
CTTCTTCAGA GTCTGCCTGA AGCCTGGGCT CTCAGAGGAG GCCGCCGAGT CCCCGTGCGC 240
CCTGGGCGCG GCGCTGAGTG CGCGCGGACC GGTCTACACC GAGCAGCCCG GAGCGCCCGC 300
GCCTGATCTC CCACTGCCCG ACGGGCTCTT GCAGGTGCCC TTCCGGGACG CCTGGCCTGC 360
CACCTTCTCT TTCATCATCG AAACCTGGAG AGAGGAGTTA GGAGACCAGA TTGGAGGGCC 420
CGCCTGGAGC CTGCTGGCGC GCGTGGCTGG CAGGCGGCGC TTGGCAGCCG GAGGCCCGTG 480
GGCCCCCGAC ATTCAGCGCG CAGCCGCCTG GGAGCTGCGC TTCTCGTACC GCGCGCGCTG 540
CGAGCCGCCT GCCGTCGGGA CCGCGTGCAC GCGCCTCTGC CGTCCGCGCA GCGCCCCCTC 600
GCGGTGCGGT CCGGGACTGC GCCCCTGCGC ACCGCTCGAG GACGAATGTG AGGCGCCGCT 660
GGTGTGCCGA GCAGCCTGCA GCCCTGAGCA TGGCTTCTGT GAACAGCCCG GTGAATGCCG 720
ATGCCTAGAG GGCTCCACTG GACCCCTCTG CACGGTCCCT GTCTCCACCA GCAGCTGCCT 780
CAGCCCCAGG GGCCCGTCCT CTGCTACCAC CGGATGCCTT GTCCCTGGGC CTGGGCCCTG 840
TGACGGGAAC CCGTGTGCCA ATGGAGGCAG CTGTAGTGAG ACACCCAGGT CCTTTGAATG 900
CACCTGCCCG CGTGGGTTCT ACGGGCTGCG GTGTGAGGTG AGCGGGGTGA CATGTGCAGA 960
TGGACCCTGC TTCAACGGCG GCTTGTGTGT CGGGGGTGCA GACCCTGACT CTGCCTACAT 1020
CTGCCACTGC CCACCTGGTT TCCAAGGCTC CAACTGTGAG AAGAGGGTGG ACCGGTGCAG 1080
CCTGCAGCCA TGCCGCAATG GCGGACTCTG CCTGGACCTG GGCCACGCCC TGCGCTGCCG 1140
CTGCCGCGCC GGCTTCGCGG GTCCTCGCTG CGAGCACGAC CTGGACGACT GCGCGGGCCG 1200
CGCCTGCGCT AACGCCGGCA CGTGTGTGGA GGGCGGCGGC GCGCACCGCT GCTCCTGCGC 1260
GCTGGGCTTC GGCGGCCGCG ACTGCCGCGA GCGCGCGGAC CCGTGCGCCG CGCGCCCCTG 1320
TGCTCACGGC GGCCGCTGCT ACGCCCACTT CTCCGGCCTC GTCTGCGCTT GCGCTCCCGC 1380
CTACATGGGA GCGCGGTGTG AGTTCCCAGT GCACCCCGAC GGCGCAAGCG CCTTGCCCGC 1440
GGCCCCGCCG GGCCTCAGGC CCGGGGACCC TCAGCGCTAC CTTTTGCCTC CGGCTCTGGG 1500
ACTGCTCGTG GCCGCGGGCG TGGCCGGCGC TGCGCTCTTG CTGGTCCACG TGCGCCGCCG 1560
TGGCCACTCC CAGCATGCTG GGTCTCGCTT GCTCCCTGGG ACCCCGGAGC CGTCAGTCCA 1620
CGCACTCCCG GATGCACTCA ACAACCTAAG GACGCAGGAG GGTTCCGGGG ATGGTCCGAG 1680
CTCGTCCGTA GATTGGAATC GCCCTGAAGA TGTAGACCCT CAAGGGATTT ATGTCATATC 1740
TGCTCCTTCC ATCTACGCTC GGGAGGTAGC GACGCCCCTT TTCCCCCCGC TACACACTGG 1800
GCGCGCTGCC CAGAGGCAGC ACCTGCTTTT TCCCTACCCT TCCTCGATTC TGTCCGTGAA 1860
ATGAATTGGG TAGAGTCTCT GCAAGGTTTT AAGCCCATTT TCAGTTCTAA CTTACTTTCA 1920
Seq ID NO 134 DNA Sequence
Nucleic Acid Accession If FGENESH prediction
Coding sequence 1 411
1 11 21 31 41 51
I I I I I I
ATGTGCCAGG CTTTCCTCTG GGTGCTAGGG ACACTGTGGC TTCTCAAAAA TGCCCGTTGT 60
CTGCAGCCAT ACCCACCTGA ACATGCCCAA TCTTGCCTGA TCTCAGAAGC TAAGCAGGGT 120
CAGGCCCAGT TACCACTTGG ATGGGTGAAG TGGCCCTTGC ACTTGAGGAG CTCACTGTCC 180
AAAAGGTTGG AAAGGAAGTA CCCCAGCCTA TTGAATGGGG AAATTGAAGC ACAGATATGT 240
AAAACATCTT CTCTAGAGTT ACCCAGCTGT GATCTGGTGA CAGCTGATGG TTCCACTGAA 300
GTAACTATCT CGGAAAATCT CCCTGCTGTT GGATTCCATA TCTGTCAACA GCACCACTCT 360
CATGTAGAAG GCATGGTTAA CATCTCCAAA GCCTCTTCTG GCCAAATGTA G 411
Seq ID NO 13S DNA Sequence
Nucleic Acid Accession # NM_024812 1
Coding sequence 184 621
1 11 21 31 41 51
I I I I I I
GAGAGGGCCC GGACTAGGGG CGGCGGGCAC CGCAGGAGCT CCGCGCCCCT GCAGCGCGGG 60
CGGGAGCCCG GACGCGATGT CGCCGCCGCC GCCTCCTTGC GGGCCGGGGC TGCGCCTCCG 120
GGGCTGAGCC GCCGCCAGAG CCGACAGCCG AGCAGCCGCT GGGCGCTCCC GCGGCGCAGG 180
AGGATGGGCT GCCCCCCGAG CCGGGCGGAT GCCATCGAGC CCCGCTACTA CGAGAGCTGG 240
ACCCGGGAGA CAGAATCCAC CTGGCTCACC TACACCGACT CGGACGCGCC GCCCAGCGCC 300
GCCGCCCCGG ACAGCGGCCC CGAAGCGGGC GGCCTGCACT CGGGCATGCT GGAAGATGGA 360
CTGCCCTCCA ATGGTGTGCC CCGATCTACA GCCCCAGGTG GAATACCCAA CCCAGAGAAG 420
AAGACGAACT GTGAGACCCA GTGCCCAAAT CCCCAGAGCC TCAGCTCAGG CCCTCTGACC 480
CAGAAACAGA ATGGCCTTCA GACCACAGAG GCTAAAAGAG ATGCTAAGAG AATGCCTGCA 540
AAAGAAGTCA CCATTAATGT AACAGATAGC ATCCAACAGA TGGACAGAAG TCGAAGAATC 600
ACAAAGAACT GTGTCAACTA GCAGAGAGTC CAAGCAGAAG GGCAGATGGA CTTCTTCAGT 660
GTCCTTCACG GCACTGGATC CCATCAAAGA ACCTTGAAGA AGTGGCTGCC CCTTGCTGGA 720
CCTGAATTCT ACTGAGTCCC TGGCAAGACC GTCTTACCTG GCAGCAAACT GCTGCCTGAT 780
TTGTTGGGAC CTTCTGAGCC TTCTACTTAT CATGTAAATG TATTGGCACA GTGCTTACAT 840
ATGTTAATAA ACTGCAAATG TGCAGTTCAG TTTGTCTCTT TGCAACTCCT GTAATACCCT 900
CTGGTGTAAA AGTAGTGAGT TAAAGCTACA GGTCAGTTTA TGAAACAGAA AAGTAGGAAT 960
GCATTTTCTG GGTGAAAGAG TCACACCTTA GTGCTATAAC TCTCCTGCCC ATGATAGTGT 1020
ATTCTGTTTC AGGCAAGCTT ATTCTTTCCT TCCTTCATTT TAAATATTGT CATTACAAAT 1080
CTTACCAGGT TCACTTAAAA GCTGGCTTTC ATCCAACTCT AAACCCACAT ATTGAAAAAA 1140
TCAAGGTACA GGAAAACTCC TTGTTATCCT TGTTTCCTTA GCTTGGTATG AGACAGATCG 1200
GATCCAGTTT CCCATGCACC AACCCACTGC CCATGGCATG TCTTTGGGAG GTGTCTGTGA 1260
AGCAGTCATA CCTGCTCCTC ATCTGCCTGG AAAGTCCTCC TATTCCAGTG TCCATGTTGG 1320
CCTCCAGTCC TTAATGTCAC CATGCTTGTG GCCAATGCAT CCAAATAAGG ATACCCCTCA 1 80
GGGCTCAGCT AGACATTGCA ATTTTGCATA GCTTTCCAGT TCCCTTTGCT TGTCTTCTTG 1440 ACTGTCTTCC CTCTCTACCG GGGTCACTTG CAATTGTTAA TCAAAGATTG AACACTGCGT 1500 AGGAGAGGGA GATGATCCAG AGACATGTGG CAGCAGGCAT GGCTTCCCCT TGGCCTCTCT 1560
GTACACTGCC CCAGGACTGT CATTTTGGCA TCTGCAAAGG AATCACTTTA GAAAGCCAGC 1620
ACCTGGTTGA TGTGTATTCA TACTGACATT AGATTGATGT GCACTGCATT AGAAATGAGG 1680
TAGCTGACAC AGAAAAAGGA TGTTTTGATA GGAATAATTT TCTAGTATGT CTTGAAACAT 1740
GTTCATCTGG AAGTATTTTC CTCCAAAGTA ATGTAGCATG ATTTTTCAAG GATTGTTAAC 1800
ATGCCTGGGA TTGGGAAAGA TAGGACTAAA GTTGTGCCAA ACTATATCAA TAAATTCCAT 1860
GTTTAGCAGA AATAGGCAGC CTATTGGTGT TATGTTTATG TAACATAGTC CAGAGAACTG 1920
ACATGCAGGT CAAAAGTCAG ATACGCAACC TCCTTATCTG CTAACTCTGT TATTCTTCAA 1980
ACACAAGTGG GTAGTGTCAT TTTTCCTTCC TTCCTTCCAT TGGCAGATTG TATATTTATT 2040
CACAAAACAT TAAATGTCCA TCCTGTGCCA GGTACTATGC AGATGTTGAG GGATTTGGGG 2100
TCTGGTTAGT CGTGACTATC TATCCTGAAT CTAACAGTGA CTTCATAACT AGGAGACTGA 2160
ATTAGACCCT TAAGGTATAG TGTGTGTTGC AAATCACTCT GCAATGGAAA CTTTTATATT 2220
CAGGGTAGGT TTGTGTCTTA AACTAGGTGT TCTAATCAAT GTACAAGACT TTACCATACA 2280
CGCAACTATA GTTTTTCTAA ACCTTCATCA TTTTGTGATT CTTTGAGAAA GGGCTTTTAG 2340
GAACTTTATG TTCTAAAAAA TGTTTTTAAC AATAATAAGA TAAAAGAAAA ACCTGTGATT 2400
CATATGTCCC CACTGGCATT ACTCAGCAGG AGCCCCCAGC TGCCAAAGGT TGGCAGTGAT 2460
CCTGCAAGTT CAAGGGCTCT TTCTCCCTGG GGATGTGCTT TGTGGCTTCT CTTTACAGCT 2520
TTGTTTCTGC ATCAGTTCAC TGCTGCATGT TGTTTGGAAT TTATCACCTT AAGAAAGTGT 2580
CTCTGTTTTA TATAGAAACA CTTTCTCACT TACAGGGGAG AAGGAAATGC AGGGCACATG 2640
ATCTGGCCCT CCCCAGAACA ATCTGGATTT CACGGAGACA GCAACCAGAA GTTAAACCAT 2700
GTGACTAAAA ATGCATCTGG CTACTTTTTC ATGTATGTAT GAGACAGAAA CTAATCCTTA 2760
CTATCCTATT AGGATACCAC TTTTCATTGC AAAGTTTGTG TCAATAAAGT CATTAATTTT 2820
AAACAT 2826 Seq ID NO 136 DNA Sequence
Nucleic Acid Accession If XM_040550 1
Coding sequence 82 4158
1 11 21 31 41 51
I I I I I I
CCTTGGTTTC CGTTGCAGAT TCCCACAACT CCATGCTGTG TGCTGCAGGC TGGTCCTGAA 60
CCCAGATCTC TGGCTGAGAG GATGGGGGCA GATGGGGAAA CAGTGGTTCT GAAGAACATG 120
CTCATTGGCA TCAACCTGAT CCTTCTGGGC TCCATGATCA AGCCTTCAGA GTGTCAGCTG 180
GAGGTCACCA CAGAAAGGGT CCAGAGACAG TCAGTGGAGG AGGAGGGAGG CATTGCCAAC 240
TACAACACAT CCAGCAAAGA GCAGCCTGTG GTCTTCAACC ACGTGTACAA CATTAACGTG 300
CCCTTGGACA ACCTCTGCTC CTCACCGCTA GAGGCCTCTG CTGAGCAGGA GGTGAGTGCA 360
GAAGACGAGA CTCTGGCAGA GTACATGGGC CAGACCTCAG ACCACGAGAG CCAGGTCACC 420
TTTACACACA GGATCAACTT CCCCAAAAAG GCCTGTCCAT GTGCCAGTTC AGCCCAGGTG 480
CTGCAGGAGC TGCTGAGCCG GATCGAGATG CTGCAGAGGG AGGTGTCGGT GCTGCGAGAC 540
CAGTGCAACG CCAACTGCTG CCAAGAAAGT GCTGCCACAG GACAACTGGA CTATATCCCT 600
CACTGCAGTG GCCACGGCAA CTTTAGCTTT GAGTCCTGTG GCTGCATCTG CAACGAAGGC 660
TGGTTTGGCA AGAATTGCTC GGAGCCCTAC TGCCCGCTGG GTTGCTCCAG CCGGGGGGTG 720
TGTGTGGATG GCCAGTGCAT CTGTGACAGC GAGTACAGCG GGGATGACTG TTCCGAACTC 780
CGGTGCCCAA CAGACTGCAG CTCCCGCGGG CTCTGCGTGG ACGGGGAGTG TGTCTGTGAA 840
GAGCCCTACA CTGCCGAGGA CTGCAGGGAA CTGAG TGCC CTCCGGACTG TTCGGGGAAG 900
GGGAGATGTG CCAACCCTAC CTGTTTATGC GAGGAGGGCT ACGTTGGTGA GGACTGCGGC 960
CAGCGGCAGT GTCTGAATGC CTGCAGTGGG CGAGGACAAT GTGAGGAGGG GCTCTGCGTC 1020
TGTGAAGAGG GCTACCAGGG CCCTGACTGC TCAGCAGTTG CCCCTCCAGA GGACTTGCGA 1080
GTGGCTGCTA TCAGCGACAG GTCCATTGAG CTGGAATGGG ACGGGCCGAT GGCAGTGACG 1140
GAATATGTGA TCTCTTACCA GCCGACCCCC CTGCGGGGCC TCCAGCTCCA GCAGCGGGTG 1200
CCTGGAGATT GGAGTGGTGT CACCATCACG GAGCTGGAGC CAGGTCTCAC CTACAACATC 1260
AGCGTCTACG CTGTCATTAG CAACATCCTC AGCCTTCCCA TCACTGCCAA GGTGGCCACC 1320
CATCTCTCCA CTCCTCAAGG GCTACAATTT AAGACGATCA CAGAGACCAC CGTGGAGGTG 1380
CAGTGGGAGC CCTTCTCATT TTCCTTCGAT GGGTGGGAAA TCAGCTTCAT TCCAAAGAAC 1440
AATGAAGGGG GAGTGATTGC TCAGGTCCCC AGCGATGTTA CGTCCTTTAA CCAGACAGGA 1500
CTAAAGCCTG GGGAGGAATA CATTGTCAAT GTGGTGGCTC TGAAAGAACA GGCCCGCAGC 1560
CCCCCTACCT CGGCCAGCGT CTCCACAGTC ATTGACGGCC CCACGCAGAT CCTGGTTCGC 1620
GATGTCTCGG ACACTGTGGC TTTTGTGGAG TGGATTCCCC CTCGAGCCAA AGTCGATTTC 1680
ATTCTTTTGA AATATGGCCT GGTGGGCGGG GAAGGTGGGA GGACCACCTT CCGGCTGCAG 1740
CCTCCCCTGA GCCAATACTC AGTGCAGGCC CTGCGGCCTG GCTCCCGATA CGAGGTGTCA 1800
GTCAGTGCCG TCCGAGGGAC CAACGAGAGC GATTCTGCCA CCACTCAGTT CACAACAGAG 1860
ATCGATGCCC CCAAGAACTT GCGAGTTGGT TCTCGCACAG CAACCAGCCT TGACCTCGAG 1920
TGGGATAACA GTGAAGCCGA AGTTCAGGAG TACAAGGTTG TGTACAGCAC CCTGGCGGGT 1980
GAGCAATATC ATGAGGTACT GGTCCCCAGG GGCATTCCTC CAACCACCAG GGCCACCCTG 2040
ACAGATCTGG TACCTGGCAC TGAGTATGGA GTTGGAATAT CTGCCGTCAT GAACTCACAG 2100
CAAAGCGTGC CAGCCACCAT GAATGCCAGG ACTGAACTTG ACAGTCCCCG AGACCTCATG 2160
GTGACAGCCT CCTCGGAGAC CTCCATCTCC CTCATCTGGA CCAAGGCCAG TGGCCCCATT 2220
GACCACTACC GAATTACCTT TACCCCATCC TCTG GATTG CCTCAGAAGT CACCGTACCC 2280
AAGGACAGCA CCTCATACAC ACTAACAGAT CTAGAGCCTG GGGCAGAGTA CATCATTTCC 2340
GTCACTGCTG AGAGGGGTCG GCAGCAGAGC TTGGAGTCCA CTGTGGATGC TTTCACAGGC 2400
TTCCGTCCCA TCTCTCATCT GCACTTTTCT CATGTGACCT CCTCCAGTGT GAACATCACT 2460
TGCAGTGATC CATCTCCCCC AGCAGACAGA CTCATTCTTA ACTACAGCCC CAG GATGAG 2520
GAGGAAGAGA TGATGGAGGT CTCCCTGGAT GCCACCAAGA GGCATGCTGT CCTGATGGGC 2580
CTGCAACCAG CCACAGAGTA TATTGTGAAC CTTGTGGCTG TCCATGGCAC AGTGACCTCT 2640
GAGCCCATTG TGGGCTCCAT CACCACAGGA ATTGATCCCC CAAAAGACAT CACAATTAGC 2700
AATGTGACCA AGGACTCAGT GATGGTCTCC TGGAGCCCTC CTGTTGCATC TTTCGATTAC 2760
TACCGAGTAT CATATCGACC CACCCAAGTG GGACGACTAG ACAGCTCAGT GGTGCCCAAC 2820
ACTGTGACAG AATTCACCAT CACCAGACTG AACCCAGCTA CCGAATACGA AATCAGCCTC 2880
AACAGCGTGC GGGGCAGGGA GGAAAGCGAG CGCATCTGTA CTCTTGTGCA CACAGCCATG 2940
GACAACCCTG TGGATCTGAT TGCTACCAAT ATCACTCCAA CAGAAGCCCT GCTGCAGTGG 3000
AAGGCACCAG TGGGTGAGGT GGAGAACTAC GTCATTGTTC TTACACACTT TGCAGTCGCT 3060
GGAGAGACCA TCCTTGTTGA CGGAGTCAGT GAGGAATTTC GGCTTGTTGA CCTGCTTCCT 3120
AGCACCCACT ATACTGCCAC CATGTATGCC ACCAATGGAC CTCTCACCAG TGGCACCATC 3180
AGCACCAACT TTTCTACTCT CCTGGACCCT CCGGCAAACC TGACAGCCAG TGAAGTCACC 3240
AGACAAAGTG CCCTGATCTC CTGGCAGCCT CCCACCGCAG AGATTGAAAA TTATGTCTTG 3300 ACCTACAAAT CCACCGATGG AAGCCGCAAG GAGCTGATTG TGGATGCAGA AGACACCTGG 3 60
ATTCGACTGG AGGGCCTGTT GGAGAACACA GACTACACGG TGCTCCTGCA GGCAGCACAG 3420
GACACCACGT GGAGCAGCAT CACCTCCACC GCTTTCACCA CAGGAGGCCG GGTGTTCCCT 3480
CATCCCCAAG ACTGTGCCCA GCATTTGATG AATGGAGACA CTTTGAGTGG GGTTTACCCC 3540
ATCTTCCTCA ATGGGGAGCT GAGCCAGAAA TTACAAGTGT ACTGTGATAT GACCACCGAC 3600
GGGGGCGGCT GGATTGTATT CCAGAGGCGG CAGAATGGCC AAACTGATTT TTTCCGGAAA 3660
TGGGCTGATT ACCGTGTTGG CTTCGGGAAC GTGGAGGATG AGTTCTGGCT GGGGCTGGAC 3720
AATATACACA CCATCACATC CCAGGGCCGC TATGAGCTGC GCGTGGACAT GCGGGATGGC 3780
CAAGAGGCCG CCTTCGCCTC CTACGACAGG TTCTCTGTCG AGGACAGCAG AAACCTGTAC 3840
AAACTCCGCA TAGGAAGCTA CAACGGCACT GCGGGGGACT CCCTCAGCTA TCATCAAGGA 3900
CGCCCTTTCT CCACAGAGGA TAGAGACAAT GATGTTGCAG TGACTAACTG TGCCATGTCG 3960
TACAAGGGAG CATGGTGGTA TAAGAACTGC CACCGGACCA ACCTCAATGG GAAGTACGGG 4020
GAGTCCAGGC ACAGTCAGGG CATCAACTGG TACCATTGGA AAGGCCATGA GTTCTCCATC 4080
CCCTTTGTGG AAATGAAGAT GCGCCCCTAC AACCACCGTC TCATGGCAGG GAGAAAACGG 4140
CAGTCCTTAC AGTTCTGAGC AGTGGGCGGC TGCAAGCCAA CCAATATTTT CTGTCATTTG 4200
TTTGTATTTT ATAATATGAA ACAAGGGGGG AGGGTAATAG CAATGTGTTT TGCAACATAT 4260
TAAGAGTATG TGAAGGAAGC AGGGATGTCG CAGGAATCCG CTGCCTAACA TCTGCTCTTG 4320
GTTTCTGCTG CCCTGGAGCC TGACCCTCAG TCTCCATTCT CCCTCCTACC CAGGCCTCCT 4380
CAACCTTCAC CTCCTTTCCC ACCAACCAGG AGAAGTAGGA AGTTTTCTTA AAGGGCCAAT 4440
TCAAAGCCAA GTCGTGGGGT GCAGATTGTT ATGGTGACAG GCACACACAT TTTTCTACCC 4500
TTCTTCTGAG ATGTCCTCTG CCTTCCAGGT ATTTGTGATT TTGTCACAGC CTGACATGGC 4560
CAGGTTCTCA CACTGGCCCA GAGAAAAGAG CCTCAGCAAG AGAGTTTTGC CAACAATTCC 4620
CCTTAAAAGG AAACAGATCA ACTACACCGC ATCCCAACAA CCCAGGTTCT TTTCCTTCCT 4680
TCCTTCCTTC CTCCCTTCCT TCTTTCCTGC CTTCCC 4716
Seq ID NO 137 DNA Sequence
Nucleic Acid Accession #: NM_005883.1
Coding sequence 1714..8625
1 11 21 31 41 51 i i I i i i
GGGTTTGGGG AGCAGGAGGC AGACATGTGT TGCTTTGCAC GTCATCTCCT CCTTCCACCT 60
GGCTGGGCAT GGGATGGTGA CCTCAGCTGG AACATGGGGC TCGAGCCAGA CCTCAGGGTC 120
TCCCTGCGTG TAGCCCCCAA CCCCAAGCCT GATCCCCACC GGAGACCTGA ACAGCCTTGG 180
ACATCATCGG ATCAGGGTGG GAGGTGCCAG CCTCTGCCAC CTGACTTCCA GTCCCTGTGC 240
CCCTCCCACC CTGCCCTTCC GCACTCCTGC CCTGCAGGTT CCTCAGAGGG GCAACCCAAA 300
GCCAGAGAGG GGCGGGTCTT GTCGGGCCTC CAGCCTGGAC TTCCCAGCCC CTCTGGGGCA 360
GCATCTGGGT GCCAGACCTC GGTTCCTAGG GCCTCGTTTC TCCCTCTGGG AACAGCCAAA 420
TGGTGGTCCC TGAGACTCAG GACAGACCAA GAAGAAGCCG GATGACATGG CAAGCCACAC 480
ACTGCGTCCC CTGAGCAGGA CGGGACAGCC CGACTCCATC CTCCCACCTG CGACTGAGCC 540
CCCACCCCTA CTCCTGTCCC AGCCGTGCCC CTGCTGACAT TTGGGTGGGA GGGGAGGGGA 600
TGAGGGGGCA CCTGGGGGTC AGAGAACAAA TGACGGGTGA ATACATGTGT GTGGCCAGGT 660
GGAGGAGGGA GGGGAGGAGC AGGTGGGCTG GACAGGGCCG GTGTGAGGAA GGGGCTCAGG 720
CTGGCAGGGG GAGGTGGCAA GAGGGATGGG CTGCCATTGG TGGTCTGAGA CAAAGGCGGA 780
GGGAGGAGGC GAGCGCTGAT GGGAAAGGAA CAAAGAGGGA AGGGGGGCGT GAAGGGGGTT 840
CCGGCGGGAG GGCCGAGCCG AGGGAGGAGG CGCCGGCCAG CTGGACAGAG GGAGGAGGCC 900
AGGCCAGAGC CAGAAGACCC CCAGAGGCAC AAAGAAGCCA GCGCGCTGGC GGAGTCAAGG 960
GATGGGGCAG AGACTGCCGG GGCCAGCAGG GACCAGCTGA AGGCTGCGCA GGGGGTGCGG 1020
GCCACACAGG TAGCCACCCT GAGCTCAGCC ACCGATGGAG GGTCGTGGGG CTGCTGCGGT 1080
GATGGCCCTG GGCTTGGGTC CATCTGTCCT GCCGTTTCTG CACAGCTTAG GTGTCACCCA 1140
CTGGCCTTCG TGGTGTTTTC ATTGTCCATC GGCAGGGACA GCTGGTGGTC TGTCTGCCCC 1200
GCCTGTCTGG CTGTCAGCCT CTGGGCAGGC TTGCTTTTAT GGGGGAGGGT CCTGTCTGTC 1260
TGTCTGTCGC CCTCTCTGGC TGTGAGCCTG GGGGTGCTGG GCTGGCCAGT CCCCTTGCTG 1320
GGTTAGGCTG TCCCAGCTGT CTGAGTGTTT GTCCGGCTGT CAGGATGTGT CCTGGGGGCT 1380
GGGAAGGAGA GGCCGACCCA TNGTCTGTCG GTCGACTCCT CAGTTGGACG TTCAGCTGTC 1440
TGTACGTCTG TCTGCTGGCC CATCTGTCTC CCCTTGGGGC CACCTCTCAC TCCACCTGCC 1500
CCTCTGCGCC CCGGATTGCC TCCCCAGCAC CACGTGGGCC TGTACTTGTC CACACCAGTG 1560
ACTCCTGCCT GAGACCCCCC CCCAACCCAG GATCAGGCAG GACGGCTGGG GCTTAGGTCA 1620
GGGGCCGTCT GTCCGGAAGG CATCACCGCG CCCTCCCCAG ACCATCAGCT GAACCCTCTG 1680
ACCCTGTGAT CCCAGACGCT GCACCAGCTG AAGATGGCGA GCTCCGTGGC GCCCTACGAG 1740
CAGCTGGTGA GGCAGGTGGA GGCCTTGAAG GCTGAGAACA GCCACCTGAG GCAGGAGCTA 1800
AGGGACAACT CCAGCCACCT GTCCAAGCTG GAGACAGAGA CGTCGGGCAT GAAGGAGGTC 1860
CTGAAGCACC TACAGGGAAA ACTGGAGCAG GAGGCCCGAG TGCTGGTGTC CTCGGGGCAG 1920
ACGGAGGTGC TCCAGCAGCT GAAGGCCCTA CAGATGGACA TCACCAGCCT GTACAACCTC 1980
AAGTTCCAGC CGCCCACCCT GGGCCCGGAG CCTGCCGCCC GGACCCCCGA GGGCAGCCCA 2040
GTACACGGCT CCGGGCCCTC CAAGGACAGC TTTGGGGAGC TGAGCCGGGC CACCATCCGG 2100
CTGCTGGAGG AACTGGACCG GGAACGGTGT TTCCTGCTGA ATGAGATTGA GAAGGAGGAG 2160
AAGGAGAAGC TCTGGTACTA CTCTCAGCTG CAGGGCCTGT CCAAGCGCCT GGACGAGCTG 2220
CCGCACGTGG AGACGCAGTT CTCGATGCAG ATGGACCTGA TCCGGCAGCA GCTTGAGTTC 2280
GAGGCCCAGC ACATCCGCTC GCTGATGGAG GAGCGCTTCG GCACCTCGGA CGAGATGGTG 2340
CAGCGGGCAC AGATCCGCGC CTCGCGCCTG GAGCAGATTG ACAACCAGCT GCTGGAGGCG 2400
CAGGACCGAG TGCAGCAGAC GCAGCCCCAG GCCTTGCTGG CGGTGAAGTC GGTGCCGGTG 2460
GACGAGGACC CCGAGACAGA GCTCCCCACA CACCCTGAGG ATGGCACCCC TCAGCCGGGC 2520
AACAGCAACC TGGAGGTGGT CTTCTGGCTG TTGTCCATGT TGGCGACGCG CGACCACCAG 2580
GATACAGCGC GCACGCTGCT GGCCATGTCC AGCTCGCCCG AGAGCTGCGT GGCCATGCGC 2640
CGCTCGGGCT GTCTGCCTCT GCTGCTGCAA ATCCTCCACG GCACCGAGGC CGCGGCCGCG 2700
GGTCGCGCCG GGGCCCCAGG GGCACCGGGC GCCAAGGACG CACGCATGCG CGCCAACGCG 2760
GCGCTGCACA ACATCGTCTT CTCGCAGCCG GACCACCGCC TGGCGCGCAA GGAGATGCGC 2820
GTCCTGCACG TGCTGGAGCA GATCCGGGCC TACTGCGAGA CCTGCTGGGA CTGGCTGCAG 2880
GCCCGAGACG GCGGGCCCGA CCGAGGTGGC GCCGGCAGCG CCCCGATCCC CATCGAGCCG 2940
CAGATCTGCC AGGCCACCTG TGCTGTTATG AAGCTGTCCT TTGATGAGGA GTACCGCCGT 3000
GCCATGAACG AGCTAGGTGG GCTGCAGGCC GTGGCAGAGC TGCTGCAGGT TGACTATGAG 3060
ATGCACAAGA TGACCCGGGA CCCGCTGAAC CTGCCGCTGC GCCGCTACGC GGGCATGACC 3120
CTCACCAACC TCACCTTTGG GGACGTTGCC AACAAGGCCA CCCTGTGTGC GCGCCGCGGC 3180
TGCATGGAGG CCATCGTGGC CCAGCTGGCC TCCGACAGTG AGGAGCTCCA CCAGGTGGTG 3240 TCCAGCATCC TTCGGAACTT GTCCTGGAGG GCCGACATCA ACAGCAAGAA GGTGCTGAGG 3300
GAGGCCCGCA GCGTGACTGC CCTGGTGCAG TGTGTCCTGC GGGCCACCAA GGAGTCCACC 3360
CTGAAGAGCG TGCTGAGCGC CCTGTGGAAT CTGTCTGCAC ACAGCACAGA GAACAAGGCG 3420
GCCATCTGCC AGGTGGATGG CGCCCTGGGC TTCCTGGTGA GCACCCTGAC CTACAAGTGT 3480 CAGAGCAACT CGCTGGCCAT CATCGAGAGC CCCGGCGGCA TCCTCCGCAA TGTGTCCAGC 3540
CTCGTCGCCA CCCGTGAGGA CTACAGGCAG GTGCTCCGGG ATCACAACTG TCTGCAGACG 3600
CTGCTGCAGC ATCTGACTTC GCACAGCCTG ACCATCGTGA GCAACGCGTG CGGCACGCTC 3660
TGGAACCTGT CGGCCCGCAG CGCCCGTGAC CAGGAGCTGC TGTGGGACCT GGGCGCCGTG 3720
GGCATGCTGC GTAATCTGGT GCACTCCAAG CACAAGATGA TCGCCATGGG CAGCGCCGCC 3780 GCCCTGCGCA ACCTGCTGGC CCATCGGCCC GCCAAGCACC AGGCGGCCGC CACCGCCGTG 3840
TCCCCAGGCA GCTGCGTGCC CAGCCTGTAC GTGCGCAAGC AGCCCGCGCT GGAGGCCGAG 900
CTGGACGCAC GGCACCTCGC GCAGGCGCTG GAGCACCTGG AGAAGCAGGG CCCGCCGGCA 3960
GCCGAGGCCG CCACTAAGAA GCCGCTGCCG CCCCTGCGAC ACCTGGACGG CCTGGCCCAA 4020
GACTATGCTT CCGATTCGGG CTGCTTTGAC GACGACGATG CACCGTCATC CCTGGCTGCG 4080 GCCGCGGCCA CCGGGGAGCC AGCCAGCCCT GCCGCGCTGT CCCTCTTCCT GGGCAGCCCC 4140
TTCCTGCAGG GGCAGGCGCT GGCTCGCACC CCGCCCACCC GCCGAGGCGG CAAGCAGGCA 4200
GAGAAGGACA CCAGTGGGGA GGCAGCCGTG GCGGCCAAGG CCAAGGCCAA GCTGGCGCTT 4260
GCAGTGGCGC GCATCGACCA GCTGGTGGAG GACATCTCCG CCCTGCACAC CTCGTCCGAC 4320
GATAGCTTCA GCCTCAGCTC TGGAGACCCG GGACAGGAGG CGCCACGGGA GGGCCGCGCC 4380 CAGTCCTGCT CGCCATGCCG CGGCCCGGAG GGCGGGCGCC GAGAGGCAGG AAGCCGGGCG 4440
CACCCGCTGC TGCGGCTCAA GGCGGCCCAC GCCAGCCTCT CCAACGACAG CCTCAACAGC 4500
GGCAGTGCCA GCGACGGGTA CTGCCCACGC GAACATATGC TGCCCTGCCC GCTGGCCGCA 4560
CTGGCTTCGC GCCGCGAGGA CCCCACCTGT GGGCAGCCTC GGCCCAGCCG GCTTGACCTT 4620
GACCTGCCCG GCTGCCAGGC CGAGCCCCCG GCCCGCGAGG CCACCTCCGC CGACGCCCGC 4680 GTGCGCACCA TCAAGCTGTC GCCTACCTAT CAGCACGTGC CACTGCTTGA GGGTGCCTCA 4740
AGGGCGGGTG CAGAGCCCCT CGCGGGGCCT GGAATCTCTC CACCGGCCCG GAAGCAGCCC 4800
TGGCTGCCGG CAGACCACCT GAGCAAGGTT CCCGAGAAGC TGGCGGCTGC CCCGCTGTCT 4860
GTGGCCAGCA AGGCACTGCA GAAACTGGCG GCGCAAGAGG GGCCACTCTC GCTGTCCCGA 4920
TGCAGCTCCC TTTCCTCGCT GTCCTCGGCC GGCCGCCCAG GCCCCAGCGA GGGTGGTGAC 4980 CTGGATGACA GTGACTCCTC CCTGGAGGGG CTGCAGGAGG CCCCCCCCAG CGAGGCTGAG 5040
CTGGACAGCA CGTGGCGGGC GCCCGCCGCC ACCTCGCTGC CCGTAGCCAT TCCGGCTCCC 5100
CGGCGTAACC GAGGCCGGGG CCTGGGGGTG GAAGACGCCA CGCCGTCCAG CTCGTCCCAG 5160
AACTACGTGC AGGAGACACC GCTTGTGCTG AGCCGCTGCA GCTCTGTGAG CTCGCTCCGC 5220
AGCTTCGAGA GCCCGTCCAT CGCCAGCTCC ATCCCCAGTG AACCTTGCAG CGGGCAGGGC 5280
AGCGGCACCA TCAGCCCTAG CGAGCTGCCC GACAGCCCCG GACAGACCAT GCCTCCCAGC 5340
CCCAGCAAGA CGCCACCGCT GGCGCCCGCG CCACACCGTC CCCCCGAGGC CACCCAGTTC 5400
AGCCTGCAGT GGGAGAGCTA CGTGAAGCGC TTCCTGCACA TCGCCGACTG CCCCGAGCGC 5460
TGCCGGCTGC CATCTGAGCT GGACGCAGGC AGCGTGCGCT TTACCGTGGA GAAGCCAGAC 5520
GAGAACTTCT CGTGCGCCTC CAGCCTCAGC GCGCTGGCCT TGCACGAGCA CTACGTGCAG 5580 CAGGACGTGG AGCTGCGGCT GCTGCCCTCG GCCTGCCCCG AGCGCGGCGG GGGCGCCGGG 5640
GGCGCCGGCC TCCATTTTGC AGGGCACCCC CGGCGGGAGG AGGGGCCGGC GCCCACCCGT 5700
TCTCGCCCTC GCGGCGCCGC GGACCAGGAG CTGGAACTGC TGCGGGAGTG CCTGGGAGCC 5760
GCCGTGCCTG CCCGGCTGCG CAAGGTGGCC TCCGCGCTGG TGCCAGGTCG CCGCGCACTC 5820
CCCGTGCCCG TCTACATGTT GGTGCCCGCC CCGGCCCCGG CCCAGGAGGA CGACTCCTGC 5880
ACTGACTCCG CGGAGCGCAC GCCGGTCAAC TTCTCTAGCG CCGCCTCGCT CAGCGACGAG S940
ACGCTGCAGG GACCCCCCAG GGACCAGCCC GGGGGACCAG CGCGCAGGCA AAGACCCACC 6000
GGCCGCCCCA CCTCTGCCAG ACAGGCCATG GCCCACCGGC ACAAGGCGGG AGGCGCCGGC 6060
CGCAGCGCGG AGCAGTCTCG GGGCGCGGGC AAGAACCGAG CAGGGCTGGA GCTGCCCCTG 6120
GGCCCCCCCC CGAGCGCCCC CGCAGACAAG GACGGCTCAA AGCCCGGCCG GACCCGCGGG 6180
GACGGGGCGC TCCAGTCGCT GTGCCTCACG ACGCCCACTG AGGAGGCCGT GTACTGCTTC 6240
TACGGCAACG ACTCGGACGA GGAGCCCCCG GCGGCCGCGC CCACGCCAAC CCACCGGCGC 6300
ACATCGGCCA TCCCTCGCGC TTTTACGCGG GAGCGTCCGC AGGGCCGGAA GGAGGCCCCT 6360
GCCCCGTCCA AGGCTGCACC AGCTGCCCCG CCGCCCGCCC CCACCCAGCC CAGCCTCATT 6420
GCTGACGAGA CCCCGCCCTG CTACTCCCTG AGCTCCTCCG CCAGCTCCCT CAGCGAGCCC 6480
GAGCCCTCGG AGCCGCCGGC CGTCCATCCA CGAGGCCGGG AGCCCGCGGT CACCAAGGAC 6540
CCGCGCCCAG GAGGCGGACG CGACAGCTCG CCCAGCCCGC GGGCCGCGGA GGAGCTTCTG 6600
CAGCGGTGCA TCAGCTCGGC CCTGCCCAGG CGCCGGCCCC CCGTGTCTGG CCTGCGGCGC 6660
CGCAAGCCCC GAGCCACCCG GCTGGATGAG CGGCCCGCAG AGCCGTCCCG GGAACGCGGC 6720
GAGGAGGCAG CGGGCTCGGA CCGCGCCTCC GACCTGGATA GCGTGGAGTG GCGCGCCATC 6780 CAGGAGGGCG CCAATTCAAT TGTCACGTGG CTGCACCAGG CAGCAGCTGC CACGCGGGAG 6840
GCCTCGTCCG AGTCCGACTC CATCCTGTCC TTCGTATCCG GGCTGTCAGT GGGATCCACC 6900
CTACAGCCCC CCAAGCACAG GAAGGGACGA CAGCCGGAGG GAGAAATGGG CAGTGCCCGG 6960
CGGCCAGAGA AAAGGGGCGC AGCCTCAGTC AAGACCAGCG GGAGCCCCCG TTCCCCTGCA 7020
GGCCCCGAGA AGCCACGTGG CACACAGAAG ACCACGCCCG GGGTGCCAGC TGTGCTCCGG 7080
GGACGAACAG TGATCTACGT CCCCAGCCCG GCACCCCGTG CCCAGCCCAA AGGGACCCCC 7140
GGCCCCCGCG CCACACCGCG GAAGGTGGCG CCCCCTTGCC TGGCACAGCC CGCGGCTCCA 7200
GCCAAAGTCC CGAGCCCCGG GCAGCAGCGC TCGCGGAGCC TACACCGGCC TGCCAAGACC 7260
TCGGAGCTGG CGACGCTGAG CCAGCCCCCC AGAAGCGCCA CACCGCCCGC CCGCCTCGCC 7320
AAGACCCCCT CCTCCAGCTC CTCCCAGACC TCGCCCGCCT CCCAGCCCCT GCCCAGAAAG 7380
CGCCCCCCGG TCACCCAGGC TGCTGGGGCC CTGCCCGGCC CCGGAGCCTC CCCGGTGCCC 7440
AAAACGCCGG CGCGCACCCT TCTGGCGAAG CAGCACAAGA CGCAGAGATC GCCCGTGCCC 7500
ATCCCGTTCA TGCAGACCCC GGCCCGGCGT GGGCCGCCAC CGCTGGCTCG GGCAGTCCCG 7560
GAGCCGGGCC CCAGGGGCCG GGCGGGGACC GAGGCGGGCC CGGGGGCGCG CGGGGGCCGC 7620
CTGGGCCTGC TGCGTGTGGC CTCAGCCCTC TCCAGCGGCA GCGAGTCCTC CGACCGCTCG 7680
GGCTTCCGGC GACAGCTAAC CTTCATCAAG GAGTCGCCGG GCTTGCGGCG CCGCCGCTCC 7740
GAGCTGTCCT CGGCCGAGTC CGCGGCCTCT GCCCCCCAGG GCGCCTCGCC CCGCCGCGGC 7800
CGGCCCGCGC TGCCCGCCGT CTTCCTCTGC TCCTCGCGCT GCGAAGAGCT CCGAGCCCCA 7860
CCCCCCCAGG GCCCGGCCCC GGCCCCCCAG CGGCCCCCCG CCCCCCGACC CAGCCCTGGC 7920
GAGCGCCCTG CCCGGCGCAC CACCTCCGAG AGCCCGTCCC GCCTGCCTGT GCGCGCGCCC 7980
GCCGCCCGGC CGGAGACTGT CAAGCGCTAC GCGTCGCTGC CGCACATCAG CGTGGCCCGC 8040
AGGCCCGACG GCGCCGTCCC CGCGGCCCCT GCCTCAGCCG ACGCCGCGCG CCGCAGCAGC 8100
GACCCGGAGC CCCGGCCGCT CCCCAGGGTG GCCGCGCCGG GCACGACCTG GCGGCGCATC 8160
CGAGATGAGG ACGTGCCCCA CATCCTGCGC AGCACGCTTC CCGCCACCCC CCTGCCACTG 8220
CCCGGCTCCA CGCCCGAGGA CGCCCCCCCC GGGCCCCCGC CGCGCAAGAC CAGCGACGCC 8280 GTGGTCCAGA CCGAGGAGGT CGCCGCCCCC AAGACCAACT CCAGCACGTC CCCGAGCCTG 8340
GAGACCAGGG AGCCCCCCGG GGCCCCCGCC GGCGGCCAGC TCTCCCTCCT CGGCAGCGAC 8400
GTGGACGGTC CCAGCCTCGC CAAGGCTCCC ATCTCCGCAC CCTTCGTGCA CGAGGGCCTG 8460
GCGGTCGCCG TGGGGGGCTT CCCCGCCAGC CGGCACGGCT CCCCCAGCCG CTCGGCCCGA 8520
GTACCCCCCT TCAACTATGT GCCCAGCCCC ATGGTGGTCG CAGCCACCAC CGACTCGGCC 8580
GCGGAGAAAG CCCCGGCCAC TGCCTCCGCC ACCCTCCTGG AATAGTGGCC TAGGCCGGCC 8640
TTCTGGAACG TTCTCTCCCG GCCCTGCGGC GCGGTCTGGC TGCCCCATGG GCCTGCGCTG 8700
TAGACGTCCC CCATAGCTCG CCCCAGGGCC TCTGCCCACC CGAGCCCCAC CACTCTCAGA 8760
ACCCCCGCCC AGCGCACCCC GACCTCGCGC CTCACCGGAA GACCTTGCCT CTGTGCCGCG 8820
GAGGTCCAGC AGGAAACGGG GCGGCCGCTA GGCCTCAAGT CCCGACCGTG GAGCGCTGGC 8880
AAGGGCGTCC TGGCCCAGCC CTGAGCGCGC GGCCCTTCCC CTGTCGCAAG CCGTTGCTTG 8940
ACCCCGGGCG AGGGAGGCGG TAGCCTCCGG GTCCGGGTCT GGGTCTGGGT CCGCTGCTTC 9000
GCAGGGACAG CGCTGGGGAG GTGACGGCGC CCGCCGCAGG TGGGGCGAGG CTGGGGGAGG 9060
GCGGCGCCGC GGCGGGCCTG CCAGCTGGGG GCCTTTGCCC CGCGCAGCGG CGAAGCCTGT 9120
AATCACTGCA GCCGCCGGTA ATTCGCTAAT GAGGGCTTTG CACCGATTGT TTTCATTCTC 9180
AGCCCCAGCT GTGGGAGTGC GGGTGGGGGT GTGGCCGAGC CCCCCCAGGA AGCCCCGCCC 9240
AGACCCTGTT CAGGGAACCC GGAGCCCAAG CGCTCCGGCG GAGCCCAAAA GGGTGGGGGT 9300
GGGAGGGGCA GAGGCCAACG GATCCCCCTG CCTGTCGCAC CCCTTGGCGG GAGACGGGAA 9360
GGCAGCGGGC TGCGTACGAT GGGACCTGGT GCAGACGCCG GGCCGGCTGA CATTTGGACC 9420
CCATCCCAGA GGAGATGCTG GCTACCAGCT GGGGCGACCC CAAGGGTCGC TGGAGTCAGT 9480
ATCGGCCCGG CGCAGCCGCG GCGGGCGAGG CCAATCCAAA GGAGACTGAG GGGAGTCCCG 9540
GCAGTGAGCC CGAGGCCCTG GGACCTGGAG CCCGCGCTGG CCTCTCCCCA GCGGAGCCTG 9600
CACGTTACGG AGACCATCAC ATGTGGGCGT GGTCAGTGCC CAGGACCGCA CCGCTGCTCA 9660
TCTTGTCCCT TTTCAATTCC CTTCTGGTTC ATGATGCATA AAGCGCTAGG CCCTAGAACT 9720
CCAGAAACAG CACAGCTGGG GCGGGGACCC AGCCTTGCCC TCCACCCGAG GCTCTGGGAC 9780
AAGGCGGGAG GTTCGGGGGC CTTCCGGCAG GTGAACGCAG GGCTCCAGAG TATTTGGTGC 9840
CAGATGAGGT GAAAGCTTAT AGAAGGGCCT GAGGGGCTCG GCTGCCTCAT CCCCTGGCGC 9900
GGGAGGCTGG GAGCTGCGCC TCCTGCGTGG GGTGGGACTC GCAGGGGCCG GGTCTCCGTG 9960
ACTCCGGCAA CGCCTCGTCC TGCAGAGGGA GCCGACAACC TCTTTTCTGC AGAAAAGCTC 10020
CAGCAGGCGC TGCCTTCACC CACGGATCTG CCCAGGCTGA AGGCACACGC TCAATGCCCC 10080
ACGTGCCTTC TCCAGGAGGA ACGAACCAGG GTTTGAGGGT TGGGTGGATG GAGCTCAAAA 10140
GGAAACCCCA GCCCCACCAC GGATGACCCA TCCCTCCCGT CCCATCCCCA GCATGGGCAA 10200
GGCCAGCCTT TCTGGCAAAA GGAGCTGTCC TCAACTCAGG GCCGCTGTGA GCAAAGCTGA 10260
CCCCAGCCCC CACCCCCAGT TAACACTGCT GCTTCTCTGA ATGCATGTCA CCCTGCACCC 10320
CATGCTCCGG GCCCACACCC TGCAGGACAA GGAGCTCCAG ACAGGACGTC CATAAGTCAC 10380
CGAGGTGTGC CACCCAGCAG GTGCTGGAGG TGCCCAATGC TCCCTCCTAG GACCTCGCAG 10440
CCAGGCAAGG CTGTCAGGTT GTTTTGGGGG AAAAGGGGGT CATCCATGGC TGAACAAAAA 10500
GCCCGGAAAA TGCAGGCTGA GTGGGGCGAC CTCCTGCCTG CCAGGAGCCC CCTTTCAGGA 10560
CACAGCGGGG GTCTCACACT TGCTGTCCCC ATCCATGGCC CGAGGGGGAA CCTGCTGGTC 10620
TCTTCTGAGC TTTTGGACTT GGGGATGCCA AACACGTGCT CACCCTCACA CTCGCCCCGG 10680
CCCGCTGCGC CCCTAATTGC CAAAGGGTAG GGAAATGGCG AAGCCAGCCA CCAGGTCGCT 10740
GGTGACAGGG CCAGGGTTAT GCAGGAAGGT GGTGCGGCAT TGCCTTCCAC ATATGTAAGT 10800
CTCTGGGCCC CGCCCTCCCA GCTCCCTGCC TCTGTTTCCC CATGTGGGCC GTGGGGAACT 10860
CCCAGAGCTA CCTCTTGGGG GAGCGTGGTG GCAGCGATGA TGGGGAGACG CCTGGAAGCT 10920
CACAGAACTT GGGTCTGCCT GGCTCCTGCC CGTGACGCCT TGCCCAGCAG CAAGGTGCGC 10980
AACATGGCTG CCAGCCCCGC CTCCCACCCC CACCCCGAGT CCTGAGCTCA CTTTCGCCTT 11040
CTCCATCCCC TGCCGTGGGG GCCACAGCCA CACCTCACCG CCCAGTCCAG CTGTGCTCCA 11100
GAAGGGGACA GGCAGTCCGC GGTCTCTGGA CAATCAACTC AAGGTACGCC CACTGCAAGG 11160
CCTCCCTCCC ACCGCGGCCC CTGCCTGGCC ACCTGGCCTC TCTGCACCAG GGTGACAAGG 11220
GGTCCTCGTC TGCCCCCCAA TGCTCCAGGG CCAGTCCTAA GGAGCTGAGG GTCTGAGGAC 11280
GCAGGGAGGG TGGAGGTGTC CTGAGGCTGA TGGACAGTGA CCGCCACTGG CCCCCAACAT 11340
GACCACACGT GGGTGCTGAA CTCGGGGCGC CGTGCCCACC GGCATGGTCC TCCCGAGCTC 11400
CGACAGCATT ACCTCACCCG GCCCCATCTG TTGCCCCCCT CCAGCCCTGA TGGCGCGCGC 11460
CTGGTCTGTC TGATTCCCCT AGCCGCCACC CCACGTTTCT GTACCGGGTT TCTGCAGTGT 11520
TAAACGGACG TGTAAATAGT GGTAAATAGT GAAAGCCTGT CCTTCCCTAA ATGTAAAGCC 11580
ATCTGTCCGG CGTAAGGACG ACACCGTCAG CTGTCCGACT CGCACACATT TAATAAACTG 11640
AGCTCTTGC 11649
Seq ID NO 138 DNA Sequence Nucleic Acid Accession tt NM_0063 Coding sequence 118 588 1 11 21 31 41 51
I I I I 1 I 1 1 1
CTCCTCACAG AAGCCTCCAG CTGGGCATCC AAGAAGAAGC AGCCTCATTT GTTTTCTGGT 60 GTCATCGTAG GTGGCCACCT ATGGCTTTTG GGAATGTAAA AAGGGCAGCT CTCTGGCATG 120 TTCCTGACTG AGGATCTCAT AACATTTAAC TTGAGGAACT TCCTCCTTTT CCAGCTTTGG 180 GAGTCAAGCT TCTCACCTGG GGCGGGTGGG TTCTGCACCA CCCTCCCACC CTCCTTCCTC 240 CGTGTGGACG ATAGAGCCAC ATCCAGCACC ACGGACAGCT CCCGGGCGCC TTCATCTCCT 300 CGTCCTCCAG GCAGCACAAG CCATTGTGGA ATCTCCACCA GGTGTACAGA ACGGTGCCTC 360 TGCGTCCTGC CACTCAGGAC CTCTCAAGTC CCCGATGTGA TGGCTCCTCA GCATGATCAG 420 GAGAAATTCC ATGATCTTGC TTATTCCTGT CTTGGGAAGT CCTTCTCCAT GTCTAACCAA 480 GATCTATATG GCTATAGCAC CAGCTCTTTG GCTCTTGGCT TGGCATGGCT AAGTTGGGAG 540 ACCAAAAAGA AGAATGTACT TCATCTGGTT GGGCTGGATT CCCTCTGATA AGCCTTCCCA 600 GTTGACTGAA AGATGAGGCT AGGCTCTAGC AAGTTGAAGT CAAACCAGCT CCTTCAAGAA 660 GCTTTGAGCA GAATGAAGTG GGGAGGACCC AGCTTCCAGC CCACCAAGCC CACTGTACCT 720 GGAGCCATCT GGGATAAGAC TTTGACCCAT GACTCCCATA TCCACAGCCT GTCCATCCTA 780 GCCCATCCCA GTTTATCCTG TATCATTTGA GCTGGGATTC CCACATCCTC TGAGTTGGAA 840 GTCCCATCTC AAGTCTTCAA TAAAGACTCT TGAATATTG 879
Seq ID NO 139 DNA Sequence
Nucleic Acid Accession II BC032726 1
Coding sequence 48 2135
1 11 21 31 l l l l CCACGCGTCC GGAACGTCTT TTTGCGGACG CCCTCGGAGC AGCCGCGATG GCCAGCACCA 60
GGAGTATCGA GCTGGAGCAC TTTGAGGAAC G GACAAAAG GCCGCGGCCG GGGTCGCGCA 120
GAGGGGCCCC CAGCTCCTCC GGGGGCAGCA GCAGCTCGCG CCCCAAGGGG AACGGGCTCA 180
TCCCCAGTCC GGCGCACAGT GCCCACTGCA GCTTCTACCG CACGCGGACC CTGCAGGCCC 240
TCAGCTCGGA GAAGAAGGCC AAGAAGGCGC GCTTCTACCG GAACGGGGAC CGCTACTTCA 300
AGGGCCTGGT GTTTGCCATC TCCAGCGACC GCTTCCCCTC CTTCGATGCG CTCCTCATAG 360
AGCTCACCCG CTCCCTGTCG GACAACGTGA ACCTGCCCCA CCGTGTCCGC ACTATCTACA 420
CCATCGACGG CAGCCGGAAG GTCACCAGCC TGGACGAGCT GCTGGAAGGT GAGAGTTACG 480
TGTGTGCATC CAATGAACCA TTTCGTAAAG TCGATTACAC CAAAAATATT AATCCAAACT 540
GGTCTGTGAA CATCAAGGGT GGGACATCCC GAGCGCTGGC TGCTGCCTCC TCTGTGAAAA 600
GTGAAGTAAA AGAAAGTAAA GATTTCATCA AACCCAAGTT AGTGACTGTG ATTCGAAGTG 660
GAGTGAAGCC TAGAAAAGCC GTGCGGATCC TTCTGAATAA AAAGACTGCT CATTCCTTTG 720
AACAAGTCTT AACAGATATC ACCGAAGCCA TTAAACTAGA CTCAGGAGTC GTCAAGAGGC 780
TCTGCACCCT GGATGGAAAG CAGGTTACTT GTCTGCAAGA CTTTTTTCCT GATGACGATG 840
TTTTTATTGC ATGTGGACCA GAAAAATTTC GTTATGCCCA AGATGACTTT GTCCTGGATC 900
ATAGTGAATG TCGTGTCCTG AAGTCATCTT ATTCTCGATC CTCAGCTGTT AAGTATTCTG 960
GATCCAAAAG CCCTGGGCCC TCTCGACGCA GCAAATCACC AGCTTCAGTT AATGGAACTC 1020
CCAGCAGCCA ACTTTCTACT CCTAAATCTA CGAAATCCTC CAGTTCCTCT CCAACTAGTC 1080
CAGGAAGTTT CAGAGGATTA AAGATTTCTG CTCATGGCAG ATCTTCTTCC AATGTAAACG 1140
GTGGACCTGA GCTTGACCGT TGCATAAGTC CTGAAGGTGT GAATGGAAAC AGATGCTCTG 1200
AATCATCAAC TCTTCTTGAG AAATACAAAA TTGGAAAGGT CATTGGTGAT GGCAATTTTG 1260
CAGTAGTCAA AGAGTGTATA GACAG TCCA CTGGAAAGGA GTTTGCCC A AAGATTATAG 1320
ACAAAGCCAA ATGTTGTGGA AAGGAACACC TGATTGAGAA TGAAGTGTCA ATACTGCGCC 1380
GAGTGAAACA TCCCAATATC ATTATGCTGG TCGAGGAGAT GGAAACAGCA ACTGAGCTCT 1440
TTCTGGTGAT GGAATTGGTC AAAGGTGGAG ATCTCTTTGA TGCAATTACT TCGTCGACCA 1500
AGTACACTGA GAGAGATGGC AGTGCCATGG TGTACAACTT AGCCAATGCC CTCAGGTATC 1560
TCCATGCCCT CAGCATCGTG CACAGAGACA TCAAACCAGA GAATCTCTTG GTGTGTGAAT 1620
ATCCTGATGG AACCAAGTCT TTGAAACTGG GAGACTTTGG GCTTGCGACT GTGGTAGAAG 1680
GCCCTTTATA CACAGTCTGT GGCACACCCA CTTATGTGGC TCCAGAAATC ATTGCTGAAA 1740
CTGGCTATCC CCTGAAGGTG GACATTTGGG CAGCTGGTGT GATCACATAC ATACTTCTCT 1800
GTGGATTCCC ACCATTCCGA AGTGAGAACA ATCTCCAGGA AGATCTCTTC GACCAGATCT 1860
TGGCTGGGAA GCTGGAGTTT CCGGCCCCCT ACTGGGATAA CATCACGCAC TCTGCCAAGG 1920
AATTAATCAG TCAAATGCTT CAGGTAAATG TTGAAGCTCG GTGTACCGCG GGACAAATCC 1980
TGAGTCACCC CTGGGTGTCA GATGATGCCT CCCAGCAGAA TAACATGCAA GCTGAGGTGA 2040
CAGGTAAACT AAAACAGCAC TTTAATAATG CGCTCCCCAA ACAGAACAGC ACTACCACCG 2100
GGGTCTCCGT CATCATGTTT GATTTGACAG TTTGAGAGGC ACCTCAGAGT TTCCTTCTTT 2160
ACCCCGCTGA GACAGTGGGA GAGCCTGAAG CAGAATCCTG AACACGGCTC TAGATAAGGA 2220
GGGGCAGATT TTCTGCAGCA AGCACTGTCA AGACAGCGGC AGGCCTG GA TGGAGCCCAT 2280
CTCTCCAGTT CCTCCCTCAG TGGAGGAGAT CCCTGTGCCT GGGGAAGCAG TCCCGGCCCC 2340
CACCCCTCCG GAATCTCCCA CCCCCCACTG TCCTCCCGCT GCCCCGGGTG GTGAGCGGGC 2400
AGGAACCTGG CGCCGCCACC GAGACTGAGC CTCCTGCAGA CGGGCGAAGC CGCCTGCTGC 2460
CGCCCAGGAA GCCAGCCCTC TGCTCGGCCT CGCCGGCCTC CCTGCTGCAG GCCTCCCTCT 2520
CTTCACCGCC TGCGCCTGAG TTCGCGGGTC CTCCGCAGGC CGCCTGGGAA CCGGAGCCTG 2580
GCGTGCCGGA GCCTGGCCTG GTGCTCTGGG CTCTGCCTTC TGGTTCCTGG AGGCATCAAA 2640
GGCTGCATCC GTTCTGCCAA CAGCTGTTCG GAGAGACTCG TTCCAGATCA TCCCGTCATT 2700
TTCAGTTTGT TGGACATTTT ACAGCTTCAC CAGGAGAATG TGCAACTTTA TTCCAGCATT 2760
CGATGCATTT TTATAGAAAC ACTTTGGAAA CACTTTGGAT GAACCAAGGC CTTTTCCTTA 2820
TTTAAGTAGA CTCAGAACAC TCCCTTTCTT TTCTTTTCTC TCTCTCTCTC TCTTTTTTTT 2880
TACGAAAGAC TTAGAATTGC ATTTGTCCTT TTGTGGGTGT CCTGTGAGAG GTGATATGGG 2940
GGCTAAGAGG ACTGGCTTTC TAATAGAAGA AGTGAGCGCC TGAGAGGACA ATTTGGTCAT 3000
TGGACACGGA TTGCAGGCTT TGAGAAGCGC TCAGAGGCCC AGGGCGGCGG GCTCAGCCAT 3060
TCGGCTTGGG GCACCAGGCT CCCCAGAGAC AATGCTCAGT ATTCATTCAT ACACAGACGA 3120
TGGAAGAAGC CACTTCTTCC CTGGGCGGTG TGGGTTTCCC CCAGCTCTTC CCACACGTGT 3180
GTTAGGAAAT GCCCGTGAAC TTGCCCTCTG GGCTTTTTAA TGAGAGGCTT GGCGCATGCG 3240
GCACCCAGCG GCTGCTTCCC TGCAAGCCAG CGACTTGCCG AGCAGAATGA GCTCTGCTCC 3300
TGAGCCCCGG TAGCTGCTTC CTCATCTGCA TTTCATCTGG AGCAGGGCAG GTAACCACAG 3360
GAGGAGGCAT GCCCGAGGCA GCCAGGACTG GGCCCGAAGG TGCTCCCTGG ATATACTCTG 3420
TGAACCTTCT GGAAGGCTGC TGGCAGTTTT TCCTTTTTGT CCACCACCCT GCTCTTTTTA 3480
ATAATTGTAC ATAATCCGTG TATTTGTTTT ACCTGCTCAT CTTCTAAACT GGCGAGCCCT 3540
A AGTTCGTT CTCATTGTTA GATTTTGCCT TTTACAAGTG TCCCCAACCT GCAATAAACT 3600
TTTCCCTCTT GAAAAAAAAA AAAAAA 3626
Seq ID NO 140 DNA Sequence
Nucleic Acid Accession It- NM_015163 2
Coding sequence 1801. 3933
1 11 21 31 41 51
I I I I I I
GAAGAAATCG AGAAAACAAG AAAGCACGAA AGCAAGCAAG CAAGAAAGCA AGCAAGAAAG 60
AAACAAAAGA AAGAAAGAAA GAAAGAAAAC AGGAAAGCAA GAAAGCACGA AAGCAAGCAA 120
GCAAGCAAGA AAGCAAGCAA GAAAGAAACA AAAGAAAGAA AGAAAGAAAG AAAGAAAAAG 180
AAAACAGGAA AGCAAGAAAG CACGAAAGCA AGCAAGCAAG CAAGAAAGCA AGCATGAAAG 240
AAACGAAAGA AAGAAAGAAA GCAAGAAAAC GGGAAAGCAA GAAAGCACGA AAGCAAGCAA 300
GCAAGCGAGC GAGAGAGAGA GAGAGAGAGA GAGAGAGAGA GAGAGAGAGA GAGAGAGAGG 360
CTGGGCGCGG TGGCTCACGC CTGTCATCCC AGCACTTTGG GAGGCTAAGG CAGGCGGACC 420
ACCTGAGGTT GGGAGTGGGA GACCAGCCTG ACCAACATGG AAAAACACCG TCTCTACTAA 480
AAGTACAAAC ATCAGCCAGG CACGGTGGCC CATGCCTGTA ATCCCAGCTA ATCAGGAGGC 540
TGAGGCAGGA GAATCGCTTG AACCTGGGAG GCGGAGGGTG CGGTGAGCCG AGATCGCACC 600
ATTGCCCTCT AGCCTGGGCA ACAAGAGTGA AACTCTGTCT CAAAAAAAAA AAGAAGAAGA 660
AGAAGAAGAA GAAGAAGAAG AAGAAGAAGA AGAAGAAGAA GAAGAAGAAG AAGAAGAGAA 720
AGTAATAAAG AAAGAAAGAA AGAAAAGGCA AGGCCAGGCA AGTCCAGGCA AGGCAAATCT 780
ACCTGCTTTC AC ACATCTG GGGAGAATCA GGAAAGTCCC CAACAACAAC AAGGCCTAAA 840
GTGGAGCTGC CATCTGTCAA ACCCGAGCGG AAGAGTCCAC GCGGGTTAAA GACACGAAGA 900
AAGACAAGGA AACCCCTGAC CAAGGAGAAG AACAATCGGG CCCAGCCAGG GTCTGTCTCC 960
CGGGGTTGTC TGGGCAACCA GGGAGGGCGG GCCTCCGAGA CTCCGTCTCG AAACATCAAT 1020 CACGATAATA ACATAAAATG AAGTTAAAAA AAGAAATCAC GCATAATTCC TAACGTGTTT 1080
GAGGCCTCGA AAGGCGAGAG GCGTACGTGT ATGTCACGGT GGGGTTGTTC TGTTTTGTTG 1140
TTTTTTTCTT TTTTCTTTTC TTCTTTTTCC CCAGAAACTC ACTTTTTAAT TATTTTGTTG 1200
CGTTTCATTT TCATTTTCAT TTTTTGGAGA CGGAGTCTCG CTCTGTCGCC CAGGCTGGGT 1260
TGCAGTGGCG CGATCTCGGC TCACTGCAAC CTCCGCCTCC CAGGTTCAAG CGATTCTCCT 1320
GCCTCAGCTC GCCCTCCCGA GTAGCTGGGA TTACAGACAG TACAGCACAG CACAGCGCCC 1380
GGCTAATGTT GTGTATTGTG AGTAGAGACG GGGTTTCACC ATACTGGCCC TGTTGGTCTG 14 0
ACCGCCTCTT GATCCACCGG CCTTGGCCTC CCAAAGTGAG GGGATGACAG GCTTGAGCCA 1500
CCGCGCAGGG CCCATTTATT TATTTTATTT TATTTATTTA TTTTAATTTA TGTATGTATG 1560
TATGTATGTA TGTATGTATT TATTTATGTA TTTATTTTTG AGACGGAGTT TCGCTCTTGT 1620
TGCTCAGACT GGAGTGCGAG CTAGCGCCTC TCTGGGTGTC CGTGCCAGTG CTGCGCGGGA 1680
AGGCACCACC ACCACAGCCG CCGCCGCTGG CCAGGGTGCT GGACAAGACG GGCCCGTCGG 1740
CCACCTCGCC AGCTCAGGCA CCCGCTGCAG CCGTCGCTGT CTCCTCCCAG ACCGGTCCCC 1800
ATGGAGGAGA TGGAAGAGGA GTTGAAATGC CCCGTGTGCG GCTCCTTCTA TCGGGAGCCC 1860
ATCATCCTGC CCTGCTCTCA CAATTTGTGT CAGGCGTGCG CCCGCAACAT CCTGGTGCAG 1920
ACCCCAGAGT CTGAATCCCC CCAGAGCCAT CGGGCCGCGG GCTCCGCGGT CTCCGACTAT 1980
GACTATCTGG ACCTGGACAA GATGAGCCTA TACAGCGAGG CGGACAGCGG CTATGGCTCC 2040
TACGGGGGGT TCGCCAGCGC CCCCACTACC CCGTGCCAGA AGTCCCCCAA CGGCGTCCGC 2100
GTGTTTCCCC CGGCTATGCC GCCACCGGCC ACCCACTTGT CACCGGCCCT GGCCCCGGTG 2160
CCCCGCAACT CCTGTATCAC CTGCCCCCAG TGTCACCGCA GCCTCATCCT GGATGACCGG 2220
GGGCTCCGCG GCTTCCCCAA GAATCGCGTA CTGGAAGGGG TAATTGACCG CTACCAGCAG 2280
AGCAAAGCCG CGGCCCTCAA GTGCCAGCTC TGCGAGAAGG CGCCCAAGGA AGCCACCGTC 2340
ATGTGCGAAC AGTGCGATGT CTTCTACTGC GATCCGTGCC GCCTGCGCTG CCACCCGCCC 2400
CGGGGGCCCC TAGCCAAGCA CCGCCTGCTG CCCCCGGCCC AGGGTCGTGT GAGCCGGAGG 2460
CTGAGCCCAC GCAAGGTCTC CACCTGCACA GACCACGAGC TGGAGAACCA CAGCATGTAC 2520
TGCGTGCAAT GCAAGATGCC CGTGTGCTAC CAGTGCTTGG AGGAGGGCAA ACACTCCAGC 2580
CACGAAGTCA AGGCTCTGGG GGCCATGTGG AAACTACATA AGAGCCAGCT CTCCCAGGCG 2640
CTGAACGCAC TGTCAGACAG GGCCAAAGAA GCCAAGGAGT TTCTGGTACA GCTGCGCAAC 2700
ATGGTCCAGC AGATCCAGGA GAACAGTGTG GAGTTTGAAG CCTGTCTGGT GGCCCAATGT 2760
GATGCCCTCA TCGATGCCCT CAACAGAAGA AAAGCCCAGC TGCTGGCCCG CGTCAACAAG 2820
GAGCATGAGC ACAAGCTGAA GGTGGTTCGA GATCAGATCT CTCACTGCAC AGTGAAATTG 2880
CGCCAGACCA CAGGTCTCAT GGAGTACTGC TTGGAGGTGA TTAAGGAAAA TGATCCTAGT 2940
GGTTTTTTGC AGATTTCTGA CGCCCTCATA AGAAGAGTGC ACCTGACTGA GGATCAGTGG 3000
GGTAAAGGCA CACTCACTCC AAGGATGACC ACGGACTTTG ACTTGAGTCT GGACAACAGC 3060
CCTCTGCTGC AATCCATCCA CCAGCTGGAT TTCGTGCAAG TGAAAGCTTC CTCTCCAGTC 3120
CCAGCAACCC CTATCCTACA GCTGGAGGAA TGTTGTACCC ACAACAACAG CGCTACGTTG 3180
TCCTGGAAAC AGCCACCTCT GTCCACGGTG CCCGCCGATG GATACATTCT GGAGCTGGAT 3240
GATGGCAACG GTGGTCAATT CCGGGAGGTG TATGTGGGGA AGGAGACAAT GTGCACTGTG 3300
GATGGTCTTC ACTTCAACAG CACATACAAC GCTCGGGTCA AGGCCTTCAA CAAAACAGCA 3360
GTCAGCCCGT ACAGCAAGAC CCTGGTCCTC CAAACGTCTG AGGTGGCCTG GTTTGCTTTC 3420
GACCCTGGCT CGGCGCACTC GGACATCATC CTCTCCAATG ACAACCTGAC AGTGACCTGT 3480
AGT AGCT ATG ATGACCGGGT GGTGCTAGGG AAGACTGGCT TCTCCAAGGG CATCCACTAC 3540
TGGGAGCTCA CGGTAGATCG CTATGACAAC CACCCTGATC CTGCCTTTCC TGTGGCTCGC 3600
ATGGACGTGA TGAAGGATGT GATGTTAGGA AAAGACGACA AAGCTTGGGC AATGTATGTG 3660
GACAATAACC GGAGCTGGTT CATGCACAAC AACTCGCACA CCAACAGAAC TGAGGGAGGG 3720
ATCACAAAAG GGGCCACAAT TGGGGTCCTC CTCGACTTAA ATAGAAAAAA CTTGACATTT 3780
TTTATCAACG ATGAACAACA AGGTCCCATA GCATTTGATA ACGTGGAGGG CCTCTTCTTC 3840
CCTGCGGTCA GCCTGAACAG GAACGTGCAG GTCACGCTGC ACACCCCGCT CCCAGTCCCC 3900
GACTTCTACT CCAGCAGAGC ATCAATAGCC TAAGGATGTG CCGTGGAGGC GCCAGCTGCC 3960
TGTTCTTACC TCCGCCTGCG AGAGCCACAG CAAGGAGCTC AGCCAGCCGT GGTGGGGTGC 4020
AGAGTTGGCA GGAGTGGGAG AAGGAGGAGA GAAAAGCTGG TCCTCTGCAG TCTTTACACC 4080
CACAGCTCTG CCCTTTTCCC TTTCAACCTC TCCTCCGCTG TCATGCCTGC TTCCGCTTCC 4140
ATGTCCAACA ATTCTAACCA ACAAAGGACC TAGACAGCCC ACCAAGTCAC TTGGTTCCCA 4200
CTCCCAGATT TTGCTTTTAT TTAACTTAAT TTTTTATGTA GGTGAGTTAT ATTTTCTTTC 4260
TTTTCTGATC AGGTTATTGG TGACTTACTG GACTGGCACC GCCAGGAGAA AATTCTCCTG 4320
CTAACTTTTT TTCTTAAGCT TTCTGTCAAA CAATGAGGTT GTAGGGGGAG GTAGGGAAGA 4380
ATGAGCTGAA TTTGTAGCAT ACAGCTTACC TGCTAGAATG TTCTTACCCT CTTACCTCTC 4440
CTGTAGCGTT AGCTCTGCAG AGCTAAGCTT TGGGAGAATG AATCTATCAC TGAGAAGTTT 4500
TACTACTCAT TGAAGCACAA AAATATCCGC TACACACCTT CACATCAGGG TAGGATCGTT 4560
AGGATGGCTC TATAATTAGG ATAGGCCAGA ACCCTCCCCA CTGTATAAAA TTGGAAAGTC 4620
TCTAAGACAC AGGCAAACCA GGGGACTTAA TGATTTGGTT CGTTTATTTA ATAAAAGCTT 4680
TTAATTGAGA ACCTACTATT GACCAGGCAC TGTTCAAGAC ACTAGAACAT TATGTTCTAG 4740
ACACTGTGGC GACACAGTGG TGAACAGACA GGCATGGTCT CTGCCCTTCG GAGCTTATAT 4800
TCCAGTAGGA GAAAAAGCAA AAATAAAATA ATTATAAATG GTCATATGTA CTAGAAAGGA 4860
AATGGGCAAG GGTCAAAGAG ACTCATGGGC AAGATCTTTC AGGCTTCCTA GAATGATGCT 4920
AAAAATCCAC ACATTCTGGC CATAGCACCA GAAATGTACC AACTCAATGC CTTTTCAGCT 4980
GCACTATTTA ATTATGGTAC CTGCTGCCAC TCATCACAGA GCCCTTCTTG GTAGAAATGA 5040
TGTCAGCATT CTTATTTGCT GATGCTGCTA TGATACCACG CCTTAAAAAT TGACAGTTGA 5100
AAAAAAAAAG AGTGACCAGA GGGCAAAGGA CCCATTCTCA GTAATGGGAG ATCTTGAGTT 5160
GCAGTCCACA GCATTCACAT TCTCAGGATA AACATGCTTG TCTCCATATA TACTATCTGT 5220
GCCTGTTATG AATGAAAAAT CCATCCACTC TGCTGCCATT CACAGCCTAA TCTTCTGGAG 5280
TAGTCCAAAC AATGTTTGGA AAAACATGGG ACTGTATGTC ATTACTATGA CTGATAGCAG 5340
AATAATAATG CATCTTACTT CTATATAGAG ATAGACTTAC ATAGGTTACC CTTGAAATTC 5400
ATTAGTTTGT CATAAAGTTT TAGGAAAGGT AGGACCCGGA AAGAAGTTCT AATTAGTTGT 5460
CTAAATATTT TTCAGTGAGC CAAGAAATTC ACCATGAAAA AACAAGAATA ACAAATAGAA 5520
GGGAAGAGAT AGGATGGGAA AGCTAACAAA TTAAAGTTTT GGCAAAAAGG AATATATGTA 5580
AATAGCTAAT TATTTACTTT TGTGCTTACT TTATTTAGAT TATTTCTATC AGTTACAATC 5640
TTTTTCTAGT TAAGTGTACC TAATTTATGC AATGGGTGCT ATCCTGTTTA TGTGTGTCTT 5700
GGTTTTTCTT GGCTACAGAA AAACTGTTGC AGGGCAACAC TAGTTTGATA TTTGATTTAC 5760
TCTCCAATGA GACTCAATGG CTGGGCCGTG GTAGACTCAT AGTTCCTCTT GTTCTTTATT 5820
AAATTCATCC TGCTAATTAG ATTTCTAGTG ACTTGTAACA TGTAGTTTAC ACTGAATTGC 5880
AATTACAGAT GCATACAACT ACTATACTAG AAAAAATTGT CATTTCTGAT GTGCCAATAA 5940
ATGATTTTTA TGAGAGAAAA AAAAAAAAAA AAAAAAAA 5978 Seq ID NO: 141 DNA Sequence Nucleic Acid Accession || : NM_032636.2 Coding sequence 102. 1103
1 11 21 31 41 51 I I I I I I
GGGAGAAAGC CTGTTGCGTG GAAGATAAGG CGGCGCGGGA AGTGGACACA GGGTGGGCTG 60
GAGCTCAGAT CTAACTGGAC TCTCGCTCCT GCTCCCTGGA CATGGAGGAT TTGGAGGAAG 120
ATGTAAGGTT TATTGTGGAT GAGACCTTGG ACTTTGGGGG GCTGTCACCA TCTGACAGCC 180
GTGAGGAGGA AGACATAACA GTGTTGGTGA CTCCAGAGAA ACCACTTCGA CGCCGCCTCT 240 CCCACCGAAG TGACCCAAAT GCAGTGGCAC CTGCCCCCCA CCGTGTGAGG CTCAGCCTAG 300
GCCCCCTCAG TCCAGAGAAG CTGGAGGAGA TCCTCGATGA GGCCAACCGG CTGGCCGCTC 360
AGCTGGAGCA GTGTGCCCTG CAGGATCCCG AGAGCGCAGG CGAGGGCCTG GGGCCTCGCC 420
GAGTGAAGCC CAGTCCTCGG CGGGAGACCT TTGTGCTGAA GGATAGTCCT GTCCGAGACC 480
TGCTGCCCAC TGTGAACTCT TTGACGCGGA GCACCCCCTC CCCAAGCAGC CTGACGCCTC 540 GACTCCGGAG TAATGATAGG AAGGGGTCAG TCAGGGCTCT CCGGGCTACA TCTGCAAAGA 600
GGCCCTCCAA CATGAAGAGG GAGTCACCCA CTTGCAATCT GTTCCCTGCA TCCAAAAGCC 660
CAGCATCTTC TCCTCTTACC CGATCGACTC CCCCAGTCCG GGGGAGAGCC GGGCCCAGTG 720
GGAGAGCAGC AGCCAGCCCA CCCACCCCCA TCAGATCCGT CCTGCCCCCA CAGCCTTCTA 780
CCAGCAACTC TCAACGCCTG CCCCCCCCGC AGGGAGCAGC TGCTAAATCT TCCAGTCAAC 840 TGCCCATTCC CTCGGCCATC CCCAGGCCTG CCAGCCGAAT GCCACTCACC AGCCGGAGTG 900
TGCCACCTGG CAGAGGTGCC CTACCTCCGG ATTCTCTGTC AACTCGAAAA GGGCTTCCAA 960
GACCAAGCAC TGCAGGACAC AGAGTGCGGG AAAGTGGACA CAAGGTTCCT GTTTCCCAGC 1020
GACTAAATCT TCCTGTCATG GGTGCCACTC GCAGCAATCT GCAGCCCCCC AGGAAAGTGG 1080
CAGTCCCACC ACCTACCAGC TAAAGAGATC AGGACAGCAA GCAAGACTTC AGTAGCAAAC 1140 CACTACAGTC AGTACCTCCA CTCGCCTCTA CCCAGCAGAC CCTGACTCCA GCAGATTCTG 1200
GCCCAGGGAC AGGAGGAAGA GATGCCACCA GGCCTGGTCT CCCAGGAGTA GAGACCATGG 1260
GAAATGGGGT GGATTAGGAT TGAGCTGGAG AAGACTTAAA CTCTCTGGGT TGAAAGAAGA 1320
TTAGGGGAAA AGAGGTCACC TTCCAGCAGT GAAATGAACA AATAGAAGAT GAGAAGTACA 1380
GGCAAGTGGT TTGTCTTTAT CCACCCCCAC TGTTGTGGTC AGCCCCAGAG AATTTTATCT 1440 TCTTCCTTGG CATTGGTTCA CTGGACATTT CCACGTGAGC GGCCTCCGTA GCTAACCTCC 1500
CTGCCCTCTG AGGAGCCATC TTCCTGAATC GCATTCTCTA CTGGACTCTG GCCTGCTTGC 1560
AGAGGTGGCA GCACCCACCT GGTCTTCAGA AATTGTTTCC TGTGAATTCT GTGACTCCTA 1620
ATAGGCCAGT TTGTGATAAG CTTACTCTAT GAGTCTTCAT TTTTCTAAAA TAAAGTGAAT 1680 GTATTTTTAA ~ "^
Seq ID NO - GAD8 DNA Sequence
Nucleic Acid Accession ■ NM_022123 . 1
Coding sequence . 76 . .2781
1 11 21 31 41 51 i i i i i i
CCACGCGTCC GACGCCCCCC ACCCGGGAGG GGGGAGAGAG GCAAAAAGTA AGAGAGGAAA 60
AAAAATAGCA GGAAGATGGC GCCCACCAAG CCCAGCTTTC AGCAGGATCC TTCCAGGCGA 120
GAACGTTTAC AAGCATTGAG AAAGGAGAAA TCCCGAGATG CTGCTCGCTC CCGCCGCGGA 180
AAAGAAAACT TTGAGTTCTA TGAATTGGCC AAGTTGTTGC CTCTTCCTGC AGCCATTACC 240
AGCCAGCTCG ACAAGGCATC CATCATTCGA CTTACAATTA GCTATCTGAA AATGAGGGAC 300
TTTGCTAACC AGGGGGACCC TCCGTGGAAC TTGCGAATGG AAGGCCCTCC ACCTAACACA 360
TCAGTAAAAG GTGCACAGCG AAGGAGAAGC CCCAGTGCAC TAGCCATTGA AGTATTTGAA 420
GCACATTTGG GAAGCCACAT TTTGCAGTCC CTGGATGGCT TTGTATTTGC ACTAAATCAG 480
GAAGGAAAAT TTTTGTACAT TTCCGAAACA GTCTCCATCT ACCTAGGCCT CTCACAAGTG 540
GAGCTGACAG GCAGCAGTGT CTTTGACTAT GTCCACCCCG GAGATCACGT GGAGATGGCT 600
GAGCAGCTGG GCATGAAGCT CCCCCCTCCG CGGGGTCTCC TGTCACAGGG CACTGCTGAG 660
GACGGAGCCA GCTCAGCATC TTCCTCCTCT CAGTCGGAGA CCCCCGAGCC AGTGGAGTCA 720
ACCAGCCCCA GTCTGCTAAC CACTGACAAC ACTCTTGAGC GTTCCTTTTT CATCCGAATG 780
AAATCTACTC TGACCAAACG CGGTGTGCAC ATCAAATCAT CAGGATATAA GGTGATTCAC 840
ATAACAGCCC GGCTACGCCT GAGAGTGTCG CTGTCCCACG GGAGGACCGT CCCCAGCCAA 900
ATCATGGGTC TCGTGGTTGT TGCGCATGCC TTGCCTCCCC CTACGATCAA TGAAGTCAGA 960
ATTGACTGCC ATATGTTCGT CACTCGAGTA AATATGGACC TCAATATCAT TTACTGTGAA 1020
AATAGGATTA GTGATTATAT GGATCTGACC CCTGTAGATA TCGTAGGGAA GAGATGCTAC 1080
CACTTCATCC ATGCTGAAGA CGTGGAGGGC ATCAGCCACA GTCACTTGGA CTTGCTGAAT 1140
AAGGGTCAGT GTGTGACAAA GTACTATCGC TGGATGCAGA AGAACGGAGG ATATATTTGG 1200
ATACAGTCCA GTGCCACCAT AGCTATTAAT GCCAAGAATG CAAATGAAAA GAATATCATC 1260
TGGGTGAATT ACCTTCTTAG CAATCCTGAG TACAAGGACA CACCCATGGA CATCGCACAG 1320
CTCCCCCATC TGCCGGAGAA AACTTCCGAA TCCTCGGAGA CATCCGACTC TGAGTCAGAC 1380
TCTAAAGACA CCTCAGGTAT TACAGAGGAC AACGAGAACT CCAAGTCCGA CGAGAAGGGG 1440
AACCAGTCCG AGAACAGCGA AGACCCGGAG CCCGACCGGA AGAAGTCGGG CAACGCGTGT 1500
GACAACGACA TGAACTGCAA CGACGACGGC CACAGCTCCA GTAACCCGGA CAGCCGCGAC 1560
AGCGACGACA GCTTCGAGCA CTCGGACTTT GAGAACCCCA AGGCGGGCGA GGACGGCTTC 1620
GGTGCTCTGG GCGCGATGCA GATCAAGGTG GAGCGCTACG TGGAGAGCGA GTCGGACCTG 1680
CGGCTGCAGA ACTGCGAGTC ACTCACGTCC GACAGCGCCA ACCACTCC-GA CAGCGCAGGC 1740
GAGGCGGGCG CGCAGGCCTC CAGCAAGCAC CAGAAGCGCA AGAAAAGGCG GAAACGGCAA 1800
AAGGGCGGCA GCGCCAGCCG CCGGCGCCTG TCCAGCGCGT CGAGCCCAGG CGCCCTGCAC 1860
GCGGGCCTGC TGGAGCCCCC GCGGCTGCTG TCCTCCCCCA ACAGTGCCTC GGTGCTCAAG 1920
ATCAAGACGG AGATCTCAGA ACCCATCAAT TTCGACAATG ACAGCAGCAT CTGGAACTAC 1980
CCGCCCAACC GGGAGATCTC CAGCAACGAG TCCCCCTACA GCATGACCAA GCCCCCCAGC 2040
TCTGAGCACT TCCCGTCCCC GCAGGGCGGC GGCGGTGGGG GTGGCGGTGG CGGGGGGCTG 2100
CACGTGGCCA TTCCCGACTC GGTCCTCACC CCGCCCGGCG CCGACGCCGC GGCCGCCCGC 2160
AAGACTCAGT TCGGCGCCTC GGCCACCGCG GCCCTGGCCC CCGTCGCCTC CGACCCGCTG 2220
TCACCCCCGC TCTCGGCGTC CCCGCGGGAC AAGCACCCCG GGAACGCCGG CGGGGGCGGG 2280
GGCGGGGGCG GCGGCGCGGG GGGCGGCGGC CCCAGCGCGT CCAACTCCTT GCTGTACACT 2340
GGGGACCTCC AGGCGCTGCA GAGGTTGCAG GCGGGCAACG TCGTGCTCCC GCTGGTGCAC 2400
AGGGTGACCG GGACCCTGGC CGCCACCAGC ACCCCCGCGC AGAGGGTCTA CACCACGGGC 2460
ACCATCCGCT ACGCGCCCGC CGAGGTGACC CTGGCCATGC AGAGCAACCT GCTGCCCAAC 2520
GCGCACGCTG TTAACTTCGT GGACGTTAAC AGCCCCGGCT TTGGCCTCGA CCCCAAGACG 2580
CCCATGGAGA TGCTCTACCA CCACGTGCAC CGGCTCAACA TGTCAGGACC GTTCGGCCCC 2640 GCAGTGAGCG CAGCTAGCCT GACGCAGATG CCCGCCGGCA ACGTGTTCAC CACGGCCGAG 2700
GGACTCTTCT CCACGCTGCC CTTCCCCGTC TACAGCAACG GCATCCACGC CCCACAGACT 2760
CTGGAGCGCA AGGAGGACTG AGGCGCCGCC CGTCCTCCGC CCGGCCAGGC CCCGCTTGGA 2820
GGAGGCATCG TCGGCATTTT CGTTTAGACC TTTAATTCTA GCACTTTGAA TTCGAGCAGG 2880
TCAGCGTCTT CTCTCGCCAC GACGGTCCCC ATTCCACCCC CTCTTTCTTT CACCTGACTT 2940
ATTCTTTCGT GTAAAGATAT GTTTATTTTT TGCCTTCAGA GGGTCAGACG ACCAGTTGCC 3000
TGCCGTTTTG TCTTCTTCTA AGGTGTGTGT TGGGTTGTTT TGCTTTCCTT TGCATCTTTA 3060
TTAAGATGTC TTTCATGTGT ATATGCCTCT GCCATAGAAT ACTCAGTCTT GTGGTCAAGA 3120
GAGTTCTCAA GTGACAACCA TTGGGGTTTC TTCATAAAGA TCTTGATATG ATCAAGATGG 3180
AAAGAGACAA GCATAAACAA TGTGCCCTGT TTGACTAAGT CAAATGAAAT AGGGTGGTTT 3240
TTGTTTCTGT TCCTAATTCC TTTAAAAAAT AGGGGGAATA GTATTTTAGA ATTTTATGCA 3300
GAATTTAATT CTCTTTTTAC GGTTAAGATT TTAAGATTTT CTTACTTGCA CATAAAAATA 3360
ATTTGGGTTC TTAAACTTAA TTTCTGGCCT GTGACTAGAA TGTTTAAAAA AAAAAAAAAC 3420
CCTCGTGC 3428
Seq ID NO 142 DNA Sequence
Nucleic Acid Accession # XM_166946 2
Coding sequence 1 1641
1 11 21 31 41 51 i i i i i i
ATGGGCTCTG ACTCTCGGCT TCCTGAGATG GAGGAGAAAG GGTCTGCGGA CAAAGCTGGC 60
TGGTCCGGAG CTCTTCTCCC TGAGGTGAAG AACCAGGGCT TGAAACTATG TGAGTGGATG 120
CTGGTTTTGA AGGCAGAGCT GGTGGAATGG TACACGTCAG TGATTGTAGG GCAACAGGGG 180
CATCGATTAA AAATGGACCT TCTTAAGGAG AGGCACCACC GCAAGTACCT GCAGAAGCCT 240 ATCAAGCGCT GCAGCGGCCT CATGGGCCTG AACTGGAGTT TGAGACCAGC CATCTCTTCC 300
TCACCCCTTG CGAGGAGTCA AGAGAAACAC CACGGGGCAA AGGGAAACGA AGGAGTTAAG 360
GCGTTGAGCT TCAGAAAGCT CAGAAAACTA AAGCGACCCC CCACTCCTCC AAGCCAGGCT 420
AAGAGCTGCC GGGGGCGCAC GGGCAGCGCT GCGGACAGCC CGGGAGCCGC GGCGATGGCG 480
GTGCAGGCGC CGCTCCTCAG CACGCACCCT TTCGTGCCCT TCGGCTTCGG GGGCTCCCCG 540 GACGGGCTAG GGGGCGCCTT CGGAGCCCTG GACAAGGGCT GCTGTTTCGA GGACGATGAG 600
ACCGCGGCTC CGGCGGGTGC GCTGCTGTCG GGAGCCGAAG GAGGGGACGT GCGCGAGGCC 660
ACCCGCGATC TACTCAGCTT CATTGACTCG GCGTCCAGCA ACATCAAGCT GGCGCTGGAC 720
AAGCCGGGCA AGTCGAAGCG GAAGGTGAAC CACCGCAACG CCCCGACAGT CGCGGCCCCG 780
GCCCACGGCA AGGCTGCCCC CCCCCGGGAG GCGTCGCAGG CCGCCGCGGC CGCCAGCTTG 840 CAAAGCCGAA GTCTCCCCGC GCTCTTCGAC TCGCTGCGCC ACGTCCCCGG GGGTGCCGAG 900
CCGGCGCGGG GTGAGGTGGC TGCGCCGGCG GCCGGGCTAG GAGGTGCGGG CACTGGGGGC 960
GCGCGAGGGG ACGTGGCAGG CCCCGCGGGG GCCACGGCGA TCCCAGGGGC CACCAAGGTC 1020
CCGCTGCGGG CACGCAATCT GCCTCCGTCC TTCTTCACG AGCCGTCCCG GGCAGGCGGC 1080
GGCGGGTGTG GCCCGTCGGG GCCGGACGTG AGCTTGGGCG ACCTGGAGAA GGGCGCG AG 1140 GCCGTGGAGT TCTTTGAGCT GCTGGGGCCC GACTACGGCG CCGGCACGGA GGCCCCAGTC 1200
TTGCTTGCCG CCGAGCCTCT CGACGTGTTC CCCGCCGGAG CCTCCGTACT GCCCGGACCC 1260
CCGGAGCTGG AGCCCGGCCT CTTTGAGCCG CCGCCGGCAG TGGTGGGAAA CCTACTGTAC 1320
CCCGAGCCCT GGAGCGTCCC GGGCTGCTCC CCGACCAAAA AGAGCCCCCT GACTGCCCCC 1380
CGCGGCGGCT TGACCTTGAA CGAGCCCTTG AGCCCCCTGT ACCCCGCCGC TGCGGATTCT 1440 CCCGGCGGGG AGGACGGGCG GGGCCATTTG GCCTCTTTCG CCCCCTTCTT TCCAGACTGC 1500
GCCCTGCCCC CGCCGCCGCC GCCCCATCAG GTGTCCTACG AT ACAGCGC GGGCTACAGC 1560
CGCACCGCCT ATTCCAGCCT TTGCAGATCC GACGGGGTTT GGGAAGGGGC GCCGGGGGAG 1620
GAGGGGGCGC ACCGGGACTG A 1641
Seq ID NO 143 DNA Sequence
Nucleic Acid Accession tt NM_022123 1
Coding sequence 76 2781
1 11 21 31 41 51
I I I I I I
CCACGCGTCC GACGCCCCCC ACCCCCGAGG GGGGAGAGAG GCAAAAAGTA AGAGAGGAAA 60
AAAAATAGCA GGAAGATGGC GCCCACCAAG CCCAGCTTTC AGCAGGATCC TTCCAGGCGA 120
GAACGTTTAC AAGCATTGAG AAAGGAGAAA TCCCGAGATG CTGCTCGCTC CCGCCGGGGA 180
AAAGAAAACT TTGAGTTCTA TGAATTGGCC AAGTTGTTGC CTCTTCCTGC AGCCATTACC 240
AGCCAGCTCG ACAAGGCATC CATCATTCGA CTTACAATTA GCTATCTGAA AATGAGGGAC 300
TTTGCTAACC AGGGGGACCC TCCGTGGAAC TTGCGAATGG AAGGCCCTCC ACCTAACACA 360
TCAGTAAAAG GTGCACAGCG AAGGAGAAGC CCCAGTGCAC TAGCCATTGA AGTATTTGAA 420
GCACATTTGG GAAGCCACAT TTTGCAGTCC CTGGATGGCT TTGTATTTGC ACTAAATCAG 480
GAAGGAAAAT TTTTGTACAT TTCCGAAACA GTCTCCATCT ACCTACCCCT CTCACAAGTG 540
GAGCTGACAG GCAGCAGTGT CTTTGACTAT GTCCACCCCG GAGATCACGT GGAGATGGCT 600
GAGCAGCTGG GCATGAAGCT CCCCCCTGGG CGCGGTCTCC TGTCACAGGG CACTGCTGAG 660
GACGGAGCCA GCTCAGCATC TTCCTCCTCT CAGTCCCAGA CCCCCGAGCC AGTGGAGTCA 720
ACCAGCCCCA GTCTGCTAAC CACTGACAAC ACTCTTGAGC GTTCCTTTTT CATCCGAATG 780
AAATCTACTC TGACCAAACG CGGTGTGCAC ATCAAATCAT CAGGATATAA GGTGATTCAC 840
ATAACAGGCC GGCTACGCCT GAGAGTGTCG CTGTCCCACG GGAGGACCGT CCCCAGCCAA 900
ATCATGGGTC TCGTGGTTGT TGCGCATGCC TTGCCTCCCC CTACGATCAA TGAAGTCAGA 960
ATTGACTGCC ATATGTTCGT CACTCGAGTA AATATGGACC TCAATATCAT TTACTGTGAA 1020
AATAGGATTA GTGATTATAT GGATCTGACC CCTGTAGATA TCGTAGGGAA GAGATGCTAC 1080
CACTTCATCC ATGCTGAAGA CGTGGAGGGC ATCAGGCACA GTCACTTGGA CTTGCTGAAT 1140
AAGGGTCAGT GTGTGACAAA GTACTATCGC TGGATGCAGA AGAACGGAGG ATATATTTGG 1200
ATACAGTCCA GTGCCACCAT AGCTATTAAT GCCAAGAATG CAAATGAAAA GAATATCATC 1260
TGGGTGAATT ACCTTCTTAG CAATCCTGAG TACAAGCACA CACCCATGGA CATCGCACAG 1320
CTCCCCCATC TGCCGGAGAA AACTTCCGAA TCCTCGGAGA CATCCGACTC TGAGTCAGAC 1380
TCTAAAGACA CCTCAGGTAT TACAGAGGAC AACGAGAACT CCAAGTCCGA CGAGAAGGGG 1440
AACCAGTCCG AGAACAGCGA AGACCCGGAG CCCGACCGGA AGAAGTCGGG CAACGCGTGT 1500
GACAACGACA TGAACTGCAA CGACGACGGC CACAGCTCCA GTAACCCGGA CAGCCGCGAC 1560
AGCGACGACA GCTTCGAGCA CTCGGACTTT GAGAACCCCA AGGCGGGCGA GGACGGCTTC 1620
GGTGCTCTGG GCGCGATGCA GATCAAGGTG GAGCGCTACG TGGAGAGCGA GTCGGACCTG 1680
CGGCTGCAGA ACTGCGAGTC ACTCACGTCC GACAGCGCCA AGGACTCGGA CAGCGCAGGC 1740
GAGGCGGGCG CGCAGGCCTC CAGCAAGCAC CAGAAGCGCA AGAAAAGGCG GAAACGCCAA 1800 AAGGGCGGCA GCGCCAGCCG CCGGCGCCTG TCCAGCGCGT CGAGCCCAGG CGCCCTGCAC 1860
GCGGGCCTGG TGGAGCCCCC GCGGCTGCTG TCCTCCCCCA ACAGTGCCTC GGTGCTCAAG 1920
ATCAAGACGG AGATCTCAGA ACCCATCAAT TTCGACAATG ACAGCAGCAT CTGGAACTAC 1980
CCGCCCAACC CCGAGATCTC CAGGAACGAG TCCCCCTACA GCATGACCAA GCCCCCCAGC 2040
TCTGAGCACT TCCCGTCCCC GCAGGGCGGC GGCGGTGGGG GTGGCGGTGG CGGGGGGCTG 2100
CACGTGGCCA TTCCCGACTC GGTCCTCACC CCGCCCGGCG CCGACGGCGC GGCCGCCCGC 2160
AAGACTCAGT TCGGCGCCTC GGCCACCGCG GCCCTGCCCC CCGTCGCCTC CGACCCGCTG 2220
TCACCCCCGC TCTCGGCGTC CCCGCGGGAC AAGCACCCCG GGAACGGCGG CGGGGGCCCG 2280
GGCGCGGGCG GCGGCGCGGG GGGCGGCGGC CCCAGCGCGT CCAACTCCTT GCTGTACACT 2340
GGGGACCTGG AGGCGCTGCA GAGGTTGCAG GCGGGCAACG TCGTGCTCCC GCTGGTGCAC 2400
AGGCTGACCG GGACCCTGCC CGCCACCAGC ACGGCCGCGC AGAGGGTCTA CACCACGGGC 2460
ACCATCCGCT ACGCGCCCGC CGAGGTGACC CTGGCCATGC AGAGCAACCT GCTGCCCAAC 2520
GCGCACGCTG TTAACTTCGT GGACGTTAAC AGCCCCGGCT TTGGCCTCGA CCCCAAGACG 2580
CCCATGGAGA TGCTCTACCA CCACGTGCAC CGGCTCAACA TGTCAGGACC GTTCGCCGGC 2640
GCAGTGAGCG CAGCTAGCCT GACGCAGATG CCCGCCCCCA ACGTGTTCAC CACGGCCGAG 2 00
GGACTCTTCT CCACGCTGCC CTTCCCCGTC TACAGCAACG GCATCCACGC GGCACAGACT 2760
CTGGAGCGCA AGGAGGACTG AGGCGCCGCC CGTCCTGGGC CCGGCCAGGC CCCGCTTGGA 2820
GGAGGCATCG TCGCCATTTT CGTTTAGACC TTTAATTCTA GCACTTTGAA TTCGAGCAGG 2880
TCAGCGTCTT CTCTCGCCAC GACGGTCCCC ATTCCACCCC CTCTTTCTTT CACCTGACTT 2940
ATTCTTTCGT GTAAAGATAT GTTTATTTTT TGCCTTCAGA GGGTCAGACG ACCAGTTGCC 3000
TGCCGTTTTG TCTTCTTCTA AGGTGTGTGT TGGGTTGTTT TGCTTTCCTT TGCATCTTTA 3060
TTAAGATGTC TTTCATGTGT ATATGCCTCT GCCATAGAAT ACTCAGTCTT GTGGTCAAGA 3120
GAGTTCTCAA GTGACAACCA TTGGGGTTTC TTCATAAAGA TCTTGATATG ATCAAGATGG 3180
AAAGAGACAA GCATAAACAA TGTGCCCTGT TTGACTAAGT CAAATGAAAT AGGGTGGTTT 3240
TTGTTTCTGT TCCTAATTCC TTTAAAAAAT AGGGGGAATA GTATTTTAGA ATTTTATGCA 3300
GAATTTAATT CTCTTTTTAC GGTTAAGATT TTAAGATTTT CTTACTTGCA CATAAAAATA 3360
ATTTGGGTTC TTAAACTTAA TTTCTGGCCT GTGACTAGAA TGTTTAAAAA AAAAAAAAAC 3420 CCTCGTGC
Seq ID NO 144 DNA Sequence
Nucleic Acid Accession tt NM_005806 1
Coding sequence 105 1076
1 11 21 31 41 51
I I I I I I
CCCTGAGGCT TTTCGGAGCG AGCTCCTCAA ATCGCATCCA GATTTTCGGG TCCGAGGGAA 60
GGAGGACCCT GCGAAAGCTG CGACGACTAT CTTCCCCTGG GGCCATG AC TCGGACGCCA 120
GCCTGGTGTC CAGCCGCCCG TCGTCGCCAG AGCCCGATGA CCTTTTTCTG CCGGCCCGGA 180
GTAAGGGCAG CAGCGGCAGC GCCTTCACTG GGGGCACCGT GTCCTCGTCC ACCCCGAGTG 240
ACTGCCCGCC GGAGCTGAGC GCCGAGCTGC GCGGCGCTAT GGGCTCTGCG GGCGCGCATC 300
CTGGGGACAA GCTAGGAGGC AGTGGCTTCA AGTCGTCCTC GTCCAGCACC TCGTCGTCTA 360
CGTCGTCGGC GGCTGCGTCG TCCACCAAGA AGGACAAGAA GCAAATGACA GAGCCGGAGC 420
TGCAGCAGCT GCGTCTCAAG ATCAACAGCC GCGAGCGCAA GCGCATGCAC GACCTCAACA 480
TCGCCATGGA TGGCCTCCGC GAGGTCATGC CGTACGCACA CGGCCCTTCG GTGCGCAAGC 540
TTTCCAAGAT CGCCACGCTG CTGCTGGCGC GCAACTACAT CCTCATGCTC ACCAACTCGC 600
TGGAGGAGAT GAAGCGACTG GTGAGCGAGA TCTACGGGGG CCACCACGCT GGCTTCCACC 660
CGTCGGCCTG CGGCGGCCTG GCGCACTCCG CGCCCCTGCC CGCCGCCACC GCGCACCCGG 720
CAGCAGCAGC GCACGCCGCA CATCACCCCG CGGTGCACCA CCCCATCCTG CCGCCCGCCG 780
CCGCAGCGGC TGCTGCCGCC GCTGCAGCCG CGGCTGTGTC CAGCGCCTCT CTGCCCGGAT 840
CCGCGCTGCC GTCGGTCGGC TCCATCCGTC CACCGCACGC CCTACTCAAG TCTCCGTCTG 900
CTGCCGCGGC CGCCCCGCTG GGGGGCGGGG GCGGCGGCAG TCCGGCGAGC GGGGGCTTCC 960
AGCACTGGGG CGGCATGCCC TGCCCCTGCA GCATGTGCCA GGTGCCGCCG CCGCACCACC 1020
ACGTGTCGGC TATGGGCGCC GGCAGCCTGC CGCGCCTCAC CTCCGACGCC AAGTGAGCCG 1080
ACTGGCGCCG GCGCGTTCTG GCGACAGGGG AGCCAGGGGC CGCCCGGAAG CGAGGACTGG 1140
CCTGCGCTGG GCTCGGGAGC TCTGTCGCGA GGAGGGGCGC AGGACCATGG ACTGGGGGTG 1200
GGGCATGCTG GGGATTCCAG CATCTGCGAA CCCAAGCAAT GGGGGCGCCC ACAGAGCAGT 1260
GGGGAGTGAG GGGATGTTCT CTCCGGGACC TGATCGAGCG CTGTCTGGCT TTAACCTGAG 1320
CTGGTCCAGT AGACATCGTT TTATGAAAAG GTACCGCTGT GTGCATTCCT CACTAGAACT 1380
CATCCGACCC CCGACCACCA CCTCCGGGAA AAGATTCTAA AAACTTCTTT CCCTGAGAGC 1440
GTGGCCTGAC TTGCAGACTC GGCTTGGGCA GCACTTCGGG GGGGGAGGGG GTGTTATGGG 1500
AGGGGGACAC ATTGGGGCCT TGCTCCTCTT CCTCCTTTCT TGGCGGGTGG GAGACTCCGG 1560
GTAGCCGCAC TGCAGAAGCA ACAGCCCGAC CGCGCCCTCC AGGGTCGTCC CTGGCCCAAG 1620
GCCAGGGGCC ACAAGTTAGT TGGAAGCCGG CGTTCGGTAT CAGAAGCGCT GATGGTCATA 1680
TCCAATCTCA ATATCTGGGT CAATCCACAC CCTCTTAGAA CTGTGGCCGT TCCTCCCTGT 1740
CTCTCGTTGA TTTGGGAGAA TATGGTTTTC TAATAAATCT GTGGATGTTC CTTCTTCAAC 1800
AGTATGAGCA AGTTTATAGA CATTCAGAGT AGAACCACTT GTGGATTGGA ATAACCCAAA 1860
ACTGCCGATT TCAGGGGCGG GTGCATTGTA GTTATTATTT TAAAATAGAA ACTACCCCAC 1920
CGACTCATCT TTCCTTCTCT AAGCACAAAG TGATTTGGTT ATTTTGGTAC CTGAGAACGT 1980
AACAGAATTA AAAGGCAGTT GCTGTGGAAA CAGTTTGGGT TATTTGGGGG TTCTGTTGGC 2040 TTTTAAAAT TTTCTTTTTT GGATGTGTAA ATTTATCAAT GATGAGGTAA GTGCGCAATG 2100
CTAAGCTGTT TGCTCACGTG ACTGCCAGCC CCATCGGAGT CTAAGCCGCC TTTCCTCTAT 2160
TTTGGTTTAT TTTTGCCACG TTTAACACAA ATGGTAAACT CCTCCACGTG CTTCCTGCGT 2220
TCCGTGCAAG CCGCCTCGGC GCTGCCTGCG TTGCAAACTG GGCTTTGTAG CGTCTGCCGT 2280
GTAACACCCT TCCTCTGATC GCACCGCCCC TCGCAGAGAG TGTATCATCT GTTTTATTTT 2340
TGTAAAAACA AAGTGCTAAA TAATATTTAT TACTTGTTTG GTTGCAAAAA CGGAATAAAT 2400
GACTGAGTGT TGAGATTTTA AATAAAATTT AAAGT 2 35
Seq ID NO 145 DNA Sequence
Nucleic Acid Accession tt XM_045127 3
Coding sequence 21 4469
1 11 21 31 41 51
I I I I I I
ATGGTGCCGA GACTCTGTGC ATGACCGTGC TGGAAGAAAG CAGCATCTCT CTAATGAGTA 60
GCGTCGTAGC AGACTTCTCT GAATTTGAGG AAGATCCTCA AGTATTTAAT ACGCTTTTCC 120
CCTCCAGACC TATCGTCCCA CTTTCTTCTA GATCCATGGA AATCTCAGAG ACGAGTGTTG 180 GCATTTCTGC CGAGGTGGAT ATGAGTAGTG TTACAACCAC ACAGGTTCCC CCTGCCCACG 2 0
GCCGCCTCTC TGTGCCGGCG TCACTTGATC CTACTGCTGG CTCCTTGTCT GTTGCTGAAA 300
CCCAAGTGAC GCCATCCAGC GTGACCACTG CATTTTTCTC GGTCATCACC AGCATTCTCC 360
TTGACTCATC TTTCTCTGTC ATAGCAAACA AAAACACACC GTCGCTTGCC GTCAGAGACC 420
CGAGTGTTTT TACGCCTTAT AGTCTGGTTC CTTCAGTGGA GTCTTCACTT TTCTCTGACC 480
AAGAACGTTC CAGTTTTTCT GAGCATAAAC CCAGAGGTGC TTTGGATTTT GCATCCAGCT 540
TTTTCTCAAC ACCCCCGCTG GAACTCAGCG GCTCCATCTC TTCGCCTTCG GAAGCACCTG 600
CGTCTCTGTC TCTGATGCCG AGTGACTTGT CCCCCTTCAC ATCTCAGTCT TTTTCTCCCT 660
TGGTTGAGAC ATTTACATTG TTTGACTCTA GTGATCTGCA GTCATCTCAG CTGTCTCTTC 720
CCAGTTCCAC AAATCTTGAG TTTTCGCAGC TCCAGCCAAG TTCCGAGCTG CCTTTAAACA 780
CCATCATGTT GCTACCTAGC CGTTCTGAGG TGTCACCATG GTCAAGCTTC CCTTCTGATT 840
CTCTCGAGTT TGTTGAAGCG TCTACGGTTT CACTGACGGA TTCAGAAGCT CATTTTACCT 900
CAGCTTTCAT TGAAAC ACC TCCTATCTTG AGTCTTCACT CATTTCCCAT GAATCCGCAG 960
TCACTGCACT GGTGCCCCCC GGCTCTGAGT CTTTTGACAT TTTGACTGCC GGGATTCAAG 1020
CAACATCACC ATTGACCACT GTCCACACAA CGCCCATTTT AACTGAGTCT TCTTTGTTCT 1080
CAACTCTGAC ACCTCCTGAC GACCAAATCA GTGCTCTAGA CGGTCACGTG TCTGTCCTGG 1140
CCTCTTTCTC CAAAGCCATT CCCACTGGTA CGGTGTTGAT CACTGACGCG TACCTGCCAT 1200
CAGGATCCTC GTTTGTTTCT GAAGCAACCC CCTTCCCTCT GCCCACAGAG CTGACCGTCG 1260
TGGGCCCATC ACTCACACCC ACAGAGGTGC CACTGAACAC CTCCACGGAA GTGAGCACAA 1320
CCAGCACCGG TGCTGCCACT GGTGGTCCCC TCGACTCCAC CCTGATGGGT GACGCCGCAA 1380
GTCAGAGCCC CCCAGAGAGT AGTGCTGCTC CTCCCCTGCC ATCCCTGCGT CCCGTGACTG 1440
CCTTCACTCT CGAAGCAACA GTCGACACAC CAACACTGGC TACTGCCAAG CCGCCATATG 1500
TTTGTGATAT CACAGTCCCC GATGCCTATC TGATCACAAC TGTGCTGGCC AGAAGAGCTG 1560
TGCAGCAGTA CATCATTACA GCAATCAAAG AAGTACTGAG GATTCACTTC AACCGTGCAG 1620
TGGAACTGAA GGTTTACGAA CTATTTACTG ACTTCACTTT TCTGGTAACA TCCGGTCCTT 1680
TCGTTTACAC GGCAATATCC GTCATAAATG TGCTTATAAA CAGTAAGCTT GTCCGTGACC 1740
AGACTCCTTT AATCCTGTCT GTGAAACCTT CTTTCCTTGT GCCAGAGTCC AGGTTCCAAG 1800
TTCAAACAGT ACTTCAGTTT GTGCCTCCGA GTGTGGATAC TGGCTTCTGC AACTTCACCC 1860
AGCGCATTGA GAAAGGCCTA ATGACAGCTC TCTTTGAAGT GAGAAAACAC CACCAGGGAA 1920
CGTATAACCT CACGGTGCAG ATCTTGAATA TCACCATCAG TTCCTCAAGG GTGACTCCTC 1980
GGCGGGGCCC GGTGAATATC ATCTTTGCGG TTAAAAGCAC ACAGGGATTT TTGAATGGGT 2040
CGGAAGTGAG CGAGCTGCTC AGAAACTTGA GTGTGGTGGA GTTCAGTTTC TATCTGGGAT 2100
ACCCAGTGCT GCAGATCGCA GAGCCCTTCC AGTATCCACA GCTCAACTTA TCTCAGTTGC 2160
TGAAGTCCTC TTGGGTCAGA ACAGTTCTCC TGGGCGTCAT GGAGAAGCAA CTCCAGAATG 2220
AAGTGTTTCA AGCCGAGATG GAACGCAAGC TGGCCCAGCT GCTCAGCGAG GTTTCCACCA 2280
GAAGGCCCAT GTGGAGAAGG GCCACTGTAG CTGCAGGGAA CAGTGTGGTG CAGGTGGTAA 2340
ATGTGTCGAG GCTGGAGGGA GATGACAATC CGGTACAGCT CATCTACTTT GTGGAGGATC 2400
AAGATGGAGA AAGACTCAGT GCAGTCAAGT CTTCGGACCT GATTAACAAA ATGGACCTCC 2460
AGAGAGCAGC CATCATCTTG GGTTACCGAA TTCAAGGTGT CATTGCCCAG CCTGTCGACA 2520
GGGTGAAGAG GCCGTCTCCG GAATCCCAGA GCAACAACTT GTGGGTCATT GTTGGCGTGG 2580
TCATCCCAGT GCTGGTGGTG ATGGTGATTG TTGTCATCCT CTACTCCAAA CTATGCCGCA 2640
CAGACAAGCT AGACTTTCAG CCTGACACTG TGGCCAACAT TCAGCAGCGT CAGAAGCTGC 2700
AGATCCCTAG TGTGAAGGGC TTCGATTTTG CTAAGCAGCA TCTGGGTCAG CACAATAAAG 2760
ACGACATATT GATTATTCAT GAGCCAGCGC CACTGCCAGG ACCTCTGAAG GACCACACCA 2820
CGCCCTCGGA AAATGGAGAC GTGCCAAGCC CCAAGTCAAA GATCCCTTCC AAGAATGTTC 2880
GTCACAGAGG AAGAGTTTCT CCCTCAGATG CTGACTCTAC CCTCAGTGAA GAGTCCAGCG 2940
AGAGGGACGC AGGAGATAAG ACGCCGGGAG CCGTCAACGA TGGCAGGTCC CACAGAGCTC 3000
CGCAGAGCGG GCCACCACTG CCCAGTTCGG GAAATGAGCA GCACTCATCA GCCTCCATCT 3060
TCGAGCACGT GGACAGGATC TCCCGCCCCC CGGAGGCTAG CCGGCGGGTC CCCAGTAAGA 3120
TCCAGCTTAT CGCCATGCAG CCGATCCCGG CACCTCCCGT CCAGCGCCCC TCCCCAGCCG 3180
ACCGAGTGGC CCAAAGCAAT AAAATCAACA AAGAGATTCA GACCGCGCTG CGGCACAAGT 3240
CTGAGATCGA GCACCATCGC AACAAGATCC GCCTGCGCGC CAAGCGCCGC GGGCACTACG 3300
AGTTCCCGGT GGTAGACGAC CTGTCCTCGG GCGACACTAA GGAGCGACAC CGGGTGTACC 3360
GCAGGGCACA GATGCAGATC GACAAGATCC TGCACCCCAC GGCCAGCGTG CCCTCCGTGT 3420
TCATAGAGCC CAGGAAGAGC TCACGGATAA AACGTTCTCC CAAGCCTCGC CGGAAACACC 3480
AGGTCAACGG CTGTCCTGCC GACGCTGAGA AGGACCGGCT CATCACCACA GACAGCGATG 3540
GCACCTACAG GAGGCCCCCC GGCGTCCACA ACTCAGCCTA CATCGGATGC CCATCGGATC 600
CTGACCTCCC AGCCGATGTG CAGACACCAT CCTCGGTGGA ACTGGGGAGG TATCCAGCCC 3660
TTCCCTTCCC GGCCTCCCAG TACATCCCAC CCCAGCCGTC CATCGAGGAG GCACGCCAGA 3720
CCATGCACTC CCTCCTGGAC GACGCCTTTG CCCTCGTGGC CCCCAGCAGC CAGCCTGCCA 3780
GCACCGCAGG TGTAGGCCCC GGAGTCCCAC CCGGCCTGCC CGCAAACAGC ACCCCTTCCC 3840
AGGAAGAGAG GCGAGCCACC CAGTGGGGGT CCTTCTACAG CCCAGCCCAG ACGGCCAACA 3900
ATCCCTGCAG TAGATACGAA GACTATGGAA TGACTCCCCC GACGGGTCCA TTGCCAAGAC 3960
CAGGTTTTGG CCCCGGTTTG CTGCAGTCTA CAGAGCTGGT GCCCCCTGAC CCTCAGCAGC 4020
CACAGGCCTC CGCCGAAGCC CCATTTGCTG CCAGAGGGAT CTACTCCCAG GAGATGCCGT 4080
CGGTGGCCCG GCCTCGGCCT GTCGGGGGTA CCACAGGCTC CCAGATCCAG CACCTGACAC 4140
AGGTGGGGAT TGCCAGCAGA ATTGGAGCTC AGCCAGTGGA AATCCCGCCA AGCAGAGGCA 4200
GCCAGTATGG GGGGCCAGGC TGGCCTTCGT ACGGGGAGGA CGAAGCGGGG CGAAGAGAGG 4260
CCGTGCCAAG GACTTCACCC AGGGAGCCCT CAGCTCCTTC CGGGAACCTC CCCCACCGGG 4320
GACTGCAGGG CCCTGGGCTG GGTTACCCCA CCAGCTCCAC GGAAGACCTC CAGCCTGGCC 380
ACTCCTCGGC CTCTCTCATC AAAGCAATCC GCGAGGAGCT CCTCCGGCTC TCCCAGAAAC 4440
AGAGCACCGT GCAGAACTTC CACAGCTGAT CGGCCTCGCC TCGCAGATTT GCCAAGTATC 4500
CGCTTCCTGT GGAAGCAAGA CCAAAAGGAA ATCAACTGAG TGGGTGTTTG GAAGAGGAAG 4560
GAGCAACTCT CGGGCAGCCT GCCCAAGGGA GGGAGCAAGT TGCAATTTAG AAGATGCCAT 4620
ACGTCGTGTG ACAGCTCATG AGCCTTTCAC TGGGCTGGCA ATTGTCTGAA CACTTGGGTT 4680
CAGTTGAAAT ATATGTATTT TGGCCAAAAG CCAGCAGCAC TTCACAAAAA CAAAACACAA 4740
ACCTAAGCTA ACAAAATGAC TGCATTCGTC TCTTTTTTAA AGGTAGAGAT TAAACTGTAT 4800
AGACAGCATA GGGATGAAAG GAACCAAGCG TTTCTGTGGG ATTGAGACTG GTACGTGTAC 4860
GATGAACCTG CTGCTTTGTT TTCTGAGAAG AGGTTTGAAG ACATTTTATT AACAGCTTAA 4920
TTTTTCTCTT TTACTCCATA GGAACTTATT TTAATAGTAA CATTAACAAC AAGAATACTA 4980
AGACTGTTTG GGAATTTTAA AAAGCTACTA GTGAGAAACC AAATGATAGG TTGTAGAGCC 5040
TGATGACTCC AAACAAAGCC ATCACCCGCA TTCTTCCTCC TTCTTCTGGT GCTACAGCTC 5100
CAAGGGCCCT TCACCTTCAT GTCTGAAATG GAACTTTGGC TTTTTCAGTG GAAGAATATG 5160
TTGAAGGTTT CATTTTGTTC TAGAAAAAAA AAATCCCTCC CAAAGTGGGG CAAAAAGCTT 5220 TATATTTATT TGATTATCCA AAATACAGAT CAAAGTTTAG ATCT 5264
Seq ID NO 146 DNA Sequence
Nucleic Acid Accession It AK096568 1
Coding sequence 63 797
1 11 21 31 41 51
I I I I I I
ATCTTCGGCG GGCGAGTGGG CTCGGCCTGT GCAACCCGCA CCTGCGTCCC TCGCCCGGCC 60
CGATGGCGCC GCCCCCGCTG GGCCCCTTGG TGCTGGCGCT CGGCCCCGCC GCGGCGGTGC 120
TGGGCTCGGT GCTCTTCATC CTCTGGAAGA CCTACTTCGG CCGCCCCCGA GAGCGGCGCT 180
GGGACCGGGG AGAGGCCTGG TGGGGCGCGG AGGCTGCCCG CCTCCCCGAG TGGGACGAGT 2 0
GGGACCCCGA GGACGAGGAG GACGAGGAGC CGGCGCTGGA GGAGCTGGAA CAGCGCGAGG 300
TGCTGGTGCT GGGGCTCCAT GGCGCAGGCA AGAGCACGTT CCTGCGCGTG TTGTCGGGGA 360
AGCCACCGCT GGAAGGCCAC ATCCCCACCT GGGGCTTCAA CTCCGTGCGT CTGCCCACCA 420
AGGACTTTGA GGTGGACCTG CTAGAAATTG GGGGCAGCCA GAACCTGCGC TTCTACTGCA 480
AGGAGTTTGT GAGCGAGGTG GATGTGCTGG TGTTTGTGGT GGACTCGGCT GACCGACTGC 540
GGCTGCCCTG GGCCCGACAG GAGCTGCACA AGCTGCTGGA CAAGGACCCT GACCTGCCTG 600
TCGTCGTGGT GGCCAACAAG CAGGACCTGA GCGAGGCCAT GAGTATGGGG GAGCTGCAGC 660
GGGAGCTGGG TCTACAGGCT ATCGATAACC AGCGGGAGGT TTTCCTCTTG GCAGCCAGCA 720
TTGCCCCTGC AGGACCCACC TTTGAAGAGC CTGGCACCGT GCACATCTGG AAACTGCTCT 780
TGGAGCTCCT CTCCTAGGCT GGAGCTCTCC TGCTTGCCAC CTGCCTGTCA AGACCATAGT 840
TGTACTGCTG CTGCTTCATT GCCAGACTGG GCCTCCGGCA AGAGCCACAT GGCAGCATTT 900
CCCTTTTCCC CTCCTTTGCC TTTCAAGAGC AGGGCCTGGG CAAGGCCAAG AACCATGCAG 960
AAGCCTTCCT GGTGAGGTGG CCGTGAAGCC GAAGCAGGGA GGTGGGTGAG ACAGAGGGTG 1020
GGGAGGATAG TGTCTGGCTC ATTCCAGGCT GGAATGTGGA TCCAGCTTTC CCTTCTCTTA 1080
CCTGTACAGT GAGATGCTCA GTGGGCTCAA TCCTCCACTA CAGGTCCCCC TACCTGAGGA 1140
ACCAGTGTAG GTGTCAGAAA TACTCCTAGA GCCTCAAGGT CTCCCAGTCC AGAAACAGTC 1200
TGGTGACGTC ATGCCCTTCT CATGTGGGCA GCTTCTGAGT GGTGACACAG CAAGCCTTTG 1260
TTCCTGTCCT GCATTGTCCA GCCCCAGCTC CACCTAAGTG ACTTGTGGCC TTGTGCAATC 1320
TCTGCCTCTC TGACCCCACC GCCATTATTT TTAAAGGGAG GTGGTTTCCT AATTCGCAGA 1380
TGCCTTTCCC AGCCATGGGA GTGTGAAGTG CTAGGATGAA CCTGGCCATC CTAGCAAGGA 1440
GCTTTCTGAA GACCTCCCTG CCTTTCCCTG AGCCCACCCC TGGCCCGCCA GCCTCTCTTG 1500
ACTACAGAAT AACTGATATT CACCCACCAA ACAGAAAAAG TGAAGGCTGG GTTTTTCCCC 1560
TCTAATCTGG AGGCAAGCTG CTGCTCTCGT ACTAACTGTG CCAGTGCCCA TGTTTACAGA 1620
AGTCAGGGGA AGGAAGGAGC CTGTGTCCCT GGGACGACAG TCAACTGCAG CTAGCTGTTG 1680
ACCTCAGAAC TGCATTTTAT TTATTAATTT A AAGCAGAA CAGGCCAGAG TTCTACCCTC 1740
TGTTTCTAGG TGCTGTTTTC AAAACCCCAG ATGACAGTCA TAGAAAATTT GGAACTTAGG 1800
AAAATAGCTG GAATCATGAA TGACAATGAG ATAACATACA GATGTCAGTG GAGACAAAGT 1860
TGTGGGTTCC TCCTCCCACC TGGCTTTGAG GCTGTCGTCG ATATCATAGT ACTTTACATG 1920
GATTCACATG AACTGAAACG CCACCACTTG GCCCAGGATG TTGAAAGGGT GCAAATTCCT 1980
TCTGGGTAGA TAAGAAATGA CTCTGGGAGA GGATTTCCCT TATGTGAATC TAGGTAAAAA 2040
GATGAAAAAA AATTGTATTA TGTGATCCTA ACCACAGGAA TAGCAGACCA GCCAACCCGA 2100
TGGCCTTGGG TACATCACTC AGCCTTTCTG GACCCAATTT TTCCCCAGTG AAAGCCAAGT 2160
TGGACTGAAT TTCTGGAGTT CTCATCAGTG CACATTCCAT AGTTCTCCAG TGCTTGGCGA 2220
TCAGCCCAAT TGAAGGACTG GCTCTGTACT GACACTTATT ATCGGTACAG GCAAAGAGGA 2280
GCCTGTTGTC TGTTAGGGAC CACTAAATCA ACAACCACAA ATGGATTTTT TTTTTAAGAG 2340
GAGCTGTGCA CCTCAATTTG CTGTCTAGTT GAGAATAGAG ATTGTGTGCC TTCATTTCAT 2400
TTTCATTGCT TTGTAGTATT TTATTGTATG CATGTACCAT AATTTATTTA TCCAGTTGGA 2460
ATTTATCCTG GCAAAGATTT GCAGTAAGTC TCCAGCTGAA TTTCTTTTCA GGCGACTAGC 2520
CAGTTGCACC AACAATATTT AGTGAGTAAT CCGTCTTTTC TCCACTAATG TAAATGCCAC 2580
TTTTATTATT TATTAAATGA CCTTAAATAT TGTGGTCTAC TTCCAGACTT GCTCTTCTGC 2640
TCCATTCATC TTTCTATTTC TGAATTTGCA ATGAACAGTT TATTATTGTC ACTTTATAAT 2700
ACACTTTAAG ATCTGGCAGA GTTTGTCTCC CGCATTTCTC TTTCTTTTTC AGAACTTTTC 2760
TTGATTTCCC TGCATGATCT TTGGAATCAG CTTGTCAAGA TCCAAAATAA TCCTGTTGGT 2820
ATGTTTGTTT GTATCCCATT AAAATTATAG ATGAAAAG 2858
Seq ID NO 147 DNA Sequence
Nucle ic Acid Accession It NM_021077 1
Coding sequence 37 402
1 11 21 31 41 51
I I I I I I
CGCGCGCCCG AACGAAGCCG CGGCCCGGGC ACAGCCATGG CCCGGCGGGC GGGGGGCGCT 60 CGGATGTTCG GCAGCCTCCT GCTCTTCGCC CTGCTCGCTG CCGGCGTCGC CCCGCTCAGC 120 TGGGATCTCC CGGAGCCCCG CAGCCGAGCC AGCAAGATCC GAGTGCACTC GCGAGGCAAC 180 CTCTGGGCCA CCG TCACTT CATGGGCAAG AAGAGTCTGG AGCCTTCCAG CCCATCCCAT 240 TGGGGACAGC TCCCCACACC TCCCCTGAGG GACCAGCGAC TGCAGCTGAG TCATGATCTG 300 CTCGGAATCC TCCTGCTAAA GAAGGCTCTG GGCGTGAGCC TCAGCCGCCC CGCACCCCAA 360 ATCCAGTACA GGAGGCTGCT GGTACAAATA CTGCAGAAAT GACACCAATA ATAGGGGCAG 420 ACACAACAGC GTGGCTTAGA TTGTGCCCAC CCAGGGAAGG TGCTGAATGG GACCCTGTTG 480 ATGGCCCCAT CTGGATGTAA ATCCTGAGCT CAAATCTCTG TTACTCCATT ACTGTGATTT 540 CTGGCTCCGT CACCAGAAAT ATCGCTGATG CAGACACAGA TTATGTTCCT GCTGTATTTC 600 CTGCTTCCCT GTTGAATTGG TGAATAAAAC CTTGCTCTT 639
Seq ID NO 148 DNA Sequence
Nucleic Acid Accession tt NM_002055 1
Coding sequence 15 1313
1 11 21 31 41 51
I I I I I I
AGAGCCAGAG CAGGATGGAG AGGAGACGCA TCACCTCCGC TGCTCGCCGC TCCTACGTCT 60 CCTCAGGGGA GATGATGGTG GGGGGCCTGG CTCCTGGCCG CCGTCTCCGT CCTGGCACCC 120 GCCTCTCCCT GGCTCGAATG CCCCCTCCAC TCCCGACCCG GGTGGATTTC TCCCTGGCTG 180 GGGCACTCAA TGCTGGCTTC AAGGAGACCC GGGCCAGTGA GCGGGCAGAG ATGATGGAGC 240 TCAATGACCG CTTTGCCAGC TACATCGAGA AGGTTCGCTT CCTGGAACAG CAAAACAAGG 300 CGCTGGCTGC TGAGCTGAAC CAGCTGCGGG CCAACCAGCC CACCAAGCTG GCAGACGTCT 360 ACCAGGCTGA GCTGCGAGAG CTGCGGCTGC GGCTCGATCA ACTCACCGCC AACAGCGCCC 420
GGCTGGAGGT TGAGAGGGAC AATCTGGCAC AGGACCTGGC CACTGTGAGG CAGAAGCTCC 480
AGGATGAAAC CAACCTGAGG CTGGAAGCCG AGAACAACCT GGCTGCCTAT AGACAGGAAG 540
CAGATGAAGC CACCCTCCCC CGTCTGGATC TGGAGAGGAA GATTGAGTCG CTGGAGGAGG 600
AGATCCCCTT CTTGAGGAAG ATCCACGAGG AGGAGGTTCG GGAACTCCAG GAGCAGCTCC 660
CCCGACAGCA GGTCCATGTG GAGCTTGACG TGGCCAAGCC AGACCTCACC GCAGCCCTGA 720
AAGAGATCCG CACGCAGTAT GAGGCAATGG CGTCCAGCAA CATGCATGAA GCCGAAGAGT 780
GGTACCGCTC CAAGTTTGCA GACCTGACAG ACGCTGCTGC CCGCAACGCG GAGCTGCTCC 840
GCCAGGCCAA GCACGAAGCC AACGACTACC GCCGCCAGTT GCAGTCCTTG ACCTGCGACC 900
TGGAGTCTCT GCGCGGCACG AACGAGTCCC TGGAGAGGCA GATGCGCGAG CAGGAGGAGC 960
GGCACGTGCG GGAGGCGGCC AGTTATCAGG AGGCGCTCCC GCGGCTCCAG GAAGAGGGGC 1020
AGAGCCTCAA GGACGAGATG GCCCGCCACT TGCACCAGTA CCAGGACCTG CTCAATGTCA 1080
AGCTGGCCCT GGACATCGAG ATCGCCACCT ACAGGAAGCT GCTAGAGGGC GAGGAGAACC 1140
GGATCACCAT TCCCGTGCAG ACCTTCTCCA ACCTGCAGAT TCGAGAAACC AGCCTGGACA 1200
CCAAGTCTGT GTCAGAAGGC CACCTCAAGA GGAACATCGT GGTGAAGACC GTGGAGATGC 1260
GGGATGGAGA GGTCATTAAG GAGTCCAAGC AGGAGCACAA GGATGTGATG TGAGGCAGGA 1320
CCCACCTGGT GGCCTCTGCC CCGTCTCATG AGGGGCCCGA GCAGAAGCAG GATAGTTGCT 1380
CCGCCTCTGC TGGCACATTT CCCCAGACCT GAGCTCCCCA CCACCCCAGC TGCTCCCCTC 1440
CCTCCTCTGT CCCTAGGTCA GCTTGCTGCC CTAGGCTCCG TCAGTATCAG GCCTGCCAGA 1500
CGGCACCCAC CCAGCACCCA GCAACTCCAA CTAACAAGAA ACTCACCCCC AAGGGCAGTC 1560
TGGAGGGGCA TGGCCAGCAG CTTGCGTTAG AATGAGGAGG AAGGAGAGAA GGGGAGGAGG 1620
GCGGGGGGCA CCTACTACAT CGCCCTCCAC ATCCCTGATT CCTGTTGTTA TGGAAACTGT 1680
TGCCAGAGAT GGAGGTTCTC TCGGAGTATC TGGGAACTGT GCCTTTGAGT TTCCTCAGGC 1740
TGCTGGAGGA AAACTGAGAC TCAGACAGGA AAGGGAAGGC CCCACAGACA AGGTAGCCCT 1800
GGCCAGAGGC TTGTTTTGTC TTTTGGTTTT TATGAGGTGG GATATCCCTA TGCTGCCTAG 1860
GCTGACCTTG AACTCCTGGG CTCAAGCAGT CTACCCACCT CAGCCTCCTG TGTAGCTGGG 1920
ATTATAGATT GGAGCCACCA TGCCCAGCTC AGAGGGTTGT TCTCCTAGAC TGACCCTGAT 1980
CAGTCTAAGA TGGGTGGGGA CGTCCTGCCA CCTGGGGCAG TCACCTGCCC AGATCCCAGA 2040
AGGACCTCCT GAGCGATGAC TCAAGTGTCT CAGTCCACCT GAGCTGCCAT CCAGGGATGC 2100
CATCTGTGGG CACGCTGTGG GCAGGTGGGA GCTTGATTCT CAGCACTTGG GGGATCTGTT 2160
GTGTACGTGG AGAGGGATGA GGTGCTGGGA GGGATAGAGG GGGGCTGCCT GGCCCCCAGC 2220
TGTGGGTACA GAGAGGTCAA GCCCACCAGG ACTGCCCCGT GCAGACTGGA GGGGACGCTG 2280
GTAGAGATGG AGGAGGAGGC AATTGGGATG GCACTAGGCA TACAAGTAGG GGTTGTGGGT 2340
GACCAGTTGC ACTTGGCCTC TGGATTGTGG GAATTAAGGA AGTGACTCAT CCTCTTGAAG 2400
ATGCTGAAAC AGGAGAGAAA GGGGATGTAT CCATGGGGGC AGGGCATGAC TTTGTCCCAT 2460
TTCTAAAGGC CTCTTCCTTG CTGTGTCATA CCAGGCCGCC CCAGCCTCTG AGCCCCTGGG 2520
ACTGCTGCTT CTTAACCCCA GTAAGCCACT GCCACACGTC TGACCCTCTC CACCCCATAG 2580
TGACCCCCTG CTTTTCCCTA AGCCAAGGGC TCTTGCGGTC CCTTCTTACT CACACACAAA 2640
ATGTACCCAG TATTCTAGGT AGTGCCCTAT TTTACAATTG TAAAACTGAG GCACGAGCAA 2700
AGTGAAGACA CTGGCTCATA TTCCTGCAGC CTGGAGGCCG GGTGCTCAGG GCTGACACGT 2760
CCACCCCAGT GCACCCACTC TGCTTTGACT GAGCAGACTG GTGAGCAGAC TGGTGGGATC 2820
TGTGCCCAGA GATGGGACTG GGAGGGCCCA CTTCAGGGTT CTCCTCTCCC CTCTAAGGCC 2880
GAAGAAGGGT CCTTCCCTCT CCCCAAGACT TGGTGTCCTT TCCCTCCACT TCTTCCTGCC 2940
ACCTGCTGCT GCTGCTGCTG CTAATCTTCA GGGCACTGCT GCTGCCTTTA GTCGCTGAGG 3000
AAAAATAAAG ACAAATGCTG CGCCCTTAAA AAA 3033
Seq ID NO 149 DNA Sequence
Nucleic Acid Accession # 29126 1
Coding sequence 445 1845
1 11 21 31 41 51
I I I I I I
GAATTCCGCC TCACAGTGGC CAGGTCCTGT GCCAGATTGT CCCTCTCAAC CTCCAGCCGG 60
GCGCTGTTGG CGTGAGTTGA TCGAGCCGCA GCCGCAGCTC TCGCAGCTCA GCCTGGTAGA 120
CGTCTGCCAG CTTGGTGGGC TCCTTGGCCC GCAGCTGGTT CAGCCTCAGC AGCCAGCGCC 180
TTGTTTTGCT GTTCCAGGAA GCGAACCTTC TCGATGTAGC TGGCAAAGCG GTATTGAGCT 240
CCATCATCTC TGCCCGCTCA CTGGCCCGGG TCTCCTTGAA GCCAGCATTG AGTGCCCCAG 300
CCAGGGAGAA ATCCACCCGG GTCGGAGTGG AGGGGGCATT CGAGCCAGGG AGAGGCGGGT 360
GCACCACCCA GACGGCGGCC AGGAGCCAGG CCCCCCACCA TCATCTCCCC TGAGGAGACG 420
TAGGAGCGCC GAGCAGCGGA GGTGATGCGT CTCCTCTCCA GCCTGTCCCC CTCGTCGGTG 480
TCCTCCGATG CTGAAGAATA CCAGCCTCCT ATATGGAAAT CATACTTATA TCAGTTACAG 540
CAAGAGGCAC CTCGTCCCAA GAGAATCATT TGTCCTCGGG AGGTGGAAAA CAGACCAAAA 600
TATTATGGAA GAGAGTTTCA TGGGATCATC TCTCGGGAGC AGGCGGATGA GCTTCTTGGA 660
GGCGTGGAGG GTGCCTACAT CCTTAGAGAA AGCCAGCGCC AACCAGGATG CTACACGCTG 720
GCTCTCAGGT TTGGAAACCA GACCTTAAAC TACAGGCTCT TCCACGACGG GAAACACTTT 780
GTGGGTGAGA AGAGGTTTGA GTCGATTCAT GATCTGGTGA CAGATGGCTT GATAACACTG 840
TACATAGAAA CAAAAGCTGC CGAGTACATT TCAAAAATGA CAACTAACCC CATCTATGAA 900
CACATTGGAT ATGCCACCCT ACTCAGAGAA AAAGTATCCA GAAGGCTGAG CAGGTCTAAA 960
AATGAACCAA GAAAAACAAA CGTCACACAT GAAGAACACA CAGCCCTGGA AAAGATCTCC 1020
TCCCTGGTTC GAAGGGCTGC CCTCACACAC AACGACAACC ACTTCAATTA TGAGAAGACA 1080
CACAACTTTA AGGTCCACAC GTTCCGAGGC CCACACTCCT GTGAATATTG TGCCAATTTC 1140
ATGTGGGGGC TCATCGCCCA ACCGGTCCGG TGCTCAGACT GTGGATTGAA CGTACACAAA 1200
CAGTGTTCCA AGCACGTTCC CAATGACTGC CAACCTGATC TCAAGAGGAT CAAGAAAGTG 1260
TACTGTTGTG ACCTCACAAC ACTTGTGAAG GCTCACAACA CTCAGAGACC CATGGTGGTA 1320
GACATATGCA TTCGGGAAAT TGAAGCAAGA GGATTAAAAT CG AAGGCCT TTACAGAGTC 1380
TCTGGGTTCA CTGAACACAT TGAAGATGTC AAAATCCCAT TTGACAGAGA TGGTGAAAAG 1440
GCCGATATAT CTGCCAATGT CTATCCAGAC ATAAACATCA TCACTGGAGC CCTTAAACTG 1500
TATTTCAGAG ACTTACCCAT CCCTGTCATC ACATATGATA CCTATTCCAA ATTTATAGAT 1560
GCAGCAAAAA TCTCCAATGC AGATGAGAGG CTGGAAGCCG TCCATGAAGT GCTGATGCTG 1620
CTGCCTCCTG CCCACTATGA AACCCTCCGG TACCTAATGA TCCACCTCAA AAAGGTTACT 1680
ATGAATGAAA AAGACAATTT CATGAATGCA GAAAATCTGG GGATCGTGTT TGGGCCCACT 1740
CTGATGAGGC CCCCTGAGGA CAGCACCCTG ACCACCCTGC ATGATATGCG GTACCAAAAG 1800
CTGATTGTGC AGATTTTAAT AGAAAACGAA GACGTTTTAT TCTAATCCAT CAGGGAAATG 1860
AGCTGAATGG CCCAGCACCA TCAAGTTGAC ACAGCTAAGG ATAAAACATT TCTTACCACT 1920
TGATTTGTTT TCCAAGCAAG TGCTAGAATT TGCTGGACTG CAGAGGATCG CTGAGTGGGG 1980 TACTGTGTCT CA AGACATG CGCCACCTCC ACGTGAGAAC AAGGGTGAAG GTGAGGGAAG 2040
CCCCTCACCT TGGGTCTTTT GCTGTGCCTC CTATGTATGT CTCCTTTGCT GGAAGAGTGA 2100
TTAATACATC TTTAATTTAT TAAAAAACAA TGTAGACCTT TAAACTTCAG TCTTATTGGG 2160
AATAAAAGGG AACTTAATTC ATACAGGTAC TTGATACAGT TATACATTTT CCACTTACAA 2220
AAAGAAGACA ATTCTGTTAA ATGAAACGTG TATCGTAAAA TGTAATTTTA TTTACCCACG 2280
AGAATGTTGT TATTTTAGCA ATAGAACTCA ATGCAGATGC ATTGGTTATT ACCCTGTGTA 2340
CCTTGTCCCT CATTTTGCTG TGACACCCTG AAAAAGCTGA CCACAAATGC AGTATTATCA 2400
TTGACATACC TCTGTCCTCC TCAGTGCTTT TTAATGTAAT TTCACCGGAA TTC 2453
Seq ID NO : 150 DNA Sequence
Nucleic Acid Access ion tl : XM_113553 . 1
Coding sequence : 25 . 939
1 11 21 31 41 51
I I I I I I
CCCAGGAACC CCCAGGGAGC CAGCATGAAG CGAGCTCACC CCGAGTACAG CTCCTCGGAC 60
AGCGAGCTGG ACGAGACCAT CGAGGTGGAG AAGGAGAGTG CGGACGAGAA TGGAAACTTG 120
AGTTCGGCTC TAGGTTCCAT GTCCCCAACT ACATCTTCCC AGATTTTGGC CAGAAAAAGA 180
CGGAGAGGAA TAATTGAGAA GCGCCGACGA GACCGGATCA ATAACAGTTT GTCTGAGCTG 240
AGAAGGCTGG TACCCAGTGC TTTTGAGAAG CAGCGATCTG CTAAGCTAGA AAAAGCCGAG 300
ATCCTGCAGA TGACCGTGGA TCACCTGAAA ATGCTGCATA CGGCAGGAGG GAAAGGTTAC 360
TTTGACGCGC ACGCCCTTGC TATGGACTAT CGGAGTTTGG GATTTCGGGA ATGCCTGGCA 420
GAAGTTGCGC GTTATCTGAG CATCATTGAA GGACTAGATG CCTCTGACCC GCTTCGAGTT 480
CGACTCCTTT CGCATCTCAA CAACTACGCT TCCCAGCGGG AAGCCGCGAG CGGCGCCCAC 540
GCGGGCCTCG GACACATTCC CTGGGGGACC GTCTTCGGAC ATCACCCGCA CATCGCGCAC 600
CCGCTGTTGC TGCCCCAGAA CGGCCACGGG AACGCGGGCA CCACCCCCTC ACCCACGGAA 660
CCGCACCACC AGGGCAGGCT GGGCTCGGCA CATCCGGAGG CGCCTGCTTT GCGAGCGCCC 720
CCTAGCGGCA GCCTCGGACC GGTGCTCCCT GTGGTCACCT CCGCCTCCAA ACTGTCGCCG 780
CCTCTGCTCT CCTCAGTGGC CTCCCTGTCG GCCTTCCCCT TCTCTTTCGG CTCCTTCCAC 840
TTACTGTCTC CCAATGCACT GAGCCCTTCA GCACCCACGC AGGCTGCAAA CCTTGGCAAG 900
CCCTATAGAC CTTGGGGGAC GGAGATCGGA GCTTTTTAAA GAACTGATGT AGAATGAGGG 960
AGGGGAAAGT TTAAAATCCC AGCTGGGCTG GACTGTTGCC AACATCACCT TAAAGTCGTC 1020
AGTAAAAGTA AAAAGGAAAA AGGTACACTT TCAGATAATT TTTTTTTTAA AGACTAAAGG 1080
TTTGTTGGTT TACTTTTATC TTTTTTAATG TTTTTTTCAT CATGTCATGT ATTAGCAGTT 1140
TTTAAAAACT AGTTGTTAAA TTTTGTTCAA GACATTAAAT TGAAATAGTG AGTATAAGCC 1200
AACACTTTGT GATAGGTTTG TACTGTGCCT AATTTACTTT GTAAACCAGA ATGATTCCGT 1260
TTTTGCCTCA AAATTTGGGG AATCTTAACA TTTAGTATTT TTGGTCTGTT TTTCTCCTTG 1320
TATAGTTATG GTCTGTTTTT AGAATTAATT TTCCAAACCA CTATGCTTAA TGTTAACATG 1380
ATTCTGTTTG TTAATATTTT GACAGATTAA GGTGTTGTAT AAATAATATT CTTTTGGGGG 1440
GAGGGGAACT ATATTGAATT TTATATTTCT GAGCAAAGCG TTGACAAATC AGATGATCAG 1500
CTTTATCCAA GAAAGAAGAC TAGTAAATTG TCTGCCTCCT ATAGCAGAAA GGTGAATGTA 1560
CAAACTGTTG GTGGCCCTGA ATCCATCTGA CCAGCTGCTG GTATCTGCCA GGACTGGCAG 1620
TTCTGATTTA GTTAGGAGAG AGCCGCTGAT AGGTTAGGTC TCATTTGGAG TGTTGGTGGA 1680
AAGGAAACTG AAGGTAATTG AATAGAATAC GCCTGCATTT ACCAGCCCCA GCAACACAAA 1740
GAATTTTTAA TCACACGGAT CTCAAATTCA CAAATGTTAA CATGGATAAG TGATCATGGT 1800
GTGCGAGTGG TCAATTGAGT AGTACAGTGG AAACTGTTAA ATGCATAACC TAATTTTCCT 1860
GGGACTGCCA TATTTTCTTT TAACTGGAAA TTTTTATGTG AGTTTTCCTT TTGGTGCATG 1920
GAACTGTGGT TGCCAAGGTA TTTAAAAGGG CTTTCCTGCC TCCTTCTCTT TGATTTATTT 1980
AATTTGATTT GGGCTATAAA ATATCATTTT TCAGGTTTAT TCTTTTAGCA GGTGTAGTTA 2040
AACGACCTCC ACTGAACTCC GTTTGACCTC TGTTGTACTG ATGTGTTGTG ACTAAATAAA 2100
AAA 2103
Seq ID NO : 151 DNA Sequence
Nuc leic Ac id Accession tt : NM_001936 .2
Coding sequence : 178 . . 2589
1 11 21 31 41 51
I I I I I I
AGCAAACTCG TCTTGTCTAC CCACCCTCCC TCCCCCATCC TCCCCAAAAT AGCCTTGTGA 60
TTTCGGAAGT ATGGACTAAA ATCACACTCC TCCTTACCTT ACCGCTTGGA CTCTGGTGGC 120
TCCCAACTCG CCGTCAGACC CCACCTGCCC CGGTGGTGGG AAGCGCCTGG ACAGACCATG 180
ACCACAGCCA AGGAGCCAAG CGCTTCCCGG AAATCCGTGC AGCAGCAGGA ACAGGAGCTG 240 GTGGGGAGTA ACCCTCCGCA GAGGAATTGG AAAGGAATAG CAATTGCACT GCTTGTCATT 300 CTGGTCATCT GCTCCTTGAT CGTCACCTCG GTCATACTTC TGACACCAGC GGAAGATAAT 360
AGTCTGTCTC AAAAGAAGAA GGTCACTGTA GAAGATCTCT TCAGTGAAGA CTTCAAAATT 20 CATGACCCCG AGGCTAAGTG GATAAGTGAT ACAGAATTCA TCTACAGAGA ACAGAAAGGA 480 ACAGTGAGAC TGTGGAATGT TGAAACAAAT ACTTCTACTG TCTTAATAGA AGGCAAAAAA 540 ATTGAATCAT TAAGAGCCAT CAGATATGAA ATATCTCCAG ATAGAGAGTA TGCACTTTTT 600 TCATACAATG TGGAACCCAT ATATCAACAC TCGTATACTG GATATTACGT CCTGAGCAAA 660 ATTCCTCATG GGGATCCTCA AAGTCTGGAC CCACCAGAAG TCAGCAATGC AAAGCTTCAG 720 TATGCAGGAT GGGGCCCTAA AGGCCAACAG CTGATATTTA TTTTTGAAAA CAATATCTAC 780 TACTGTGCAC ATGTCGGGAA ACAGGCCATC CGTGTGGTCT CCACTGGCAA GGAAGGTGTG 840 ATTTACAATG GCCTCAGTGA CTGGCTGTAT GAAGAGGAGA TTTTGAAGAC ACACATCGCA 900 CACTGGTGGT CTCCGGATGG CACGAGACTC GCCTACGCCG CCATCAATGA TTCCCGTGTC 960 CCCATCATCC AGCTCCCAAC TTACACCGGC TCCATCTACC CCACCGTGAA GCCCTACCAC 1020 TATCCCAAGG CTGGAAGTGA GAACCCCAGC ATTTCCCTAC ACGTTATTGG CTTAAATGGA 1080 CCCACCCATG ATCTGGAGAT GATGCCGCCT GATGATCCAC GGATGAGGGA GTACTACATC 1140 ACCATGGTGA AGTGGGCCAC CAGCACCAAG GTCGCCGTGA CCTGGCTGAA CCGGGCGCAG 1200 AACGTGTCCA TCCTCACCCT CTGCGACGCC ACCACGGGGG TCTGCACGAA GAAACACGAG 1260 GATGAAAGTG AGGCCTCCCT CCACAGACAG AATGAAGAAC CTGTGTTCTC CAAGGATGGC 1320 CGAAAGTTTT TCTTCATCAG AGCCATCCCC CAGGGAGGAC GAGGGAAATT CTATCACATC 1380 ACCCTGTCCT CGTCCCAGCC CAACAGCAGC AACGACAACA TCCAGTCCAT CACCTCCGGG 1440 GACTGGGACG TGACCAAGAT CCTAGCCTAC GATGAGAAGG GGAATAAGAT CTACTTCCTG 1500 AGCACGGAGG ACCTGCCTCG GAGACGACAA CTCTACAGTG CCAACACGGT GGGCAACTTC 1560 AACAGGCAGT GCCTCTCCTG TGACCTGGTT GAGAACTGCA CCTACTTCAG CGCTTCCTTC 1620 AGCCATAGCA TGGACTTCTT CCTGCTCAAG TGCGAAGGTC CTGGTGTTCC TATGGTGACG 1680 GTGCACAACA CAACAGATAA GAAAAAAATG TTTGACCTAG AAACAAATGA ACATGTCAAG 1740
AAGGCCATAA ATGACCGACA GATGCCTAAA GTGGAATACA GGGACATTGA GATTGATGAT 1800
TACAACCTGC CCATGC-.GAT ACTGAAGCCA GCAACCTTCA CCGACACCAC CCACTACCCT 1860
CTGCTCCTCC TGGTGGATGG CACCCCGGGC AGCCAGAGTG TAGCTGAGAA GTTCGAGGTG 1920
AGCTGGGAGA CCCTGATGGT GAGCAGCCAC GGCGCGGTGG TGGTAAAGTG TGACGGCCGT 1980
GGCAGCGGCT TCCAAGGGAC CAAGCTCCTG CACGAAGTGA GGCCCCCCCT GGGCTTGCTG 2040
GAGGAGAAGG ACCAGATGGA GGCCGTGCGG ACGATGCTGA AGGAGCAGTA CATTGACAGG 2100
ACGCGCGTGG CCGTGTTTGG GAAGGATTAC GGTGGCTACC TGAGCACCTA CATCCTCCCA 2160
GCAAAGCGAG AAAATCAAGG CCAGACATTC ACCTGCGGCT CTGCTCTCTC TCCAATAACA 2220
GACTTCAAAC TCTATGCCTC TGCGTTTTCC GAGAGGTACT TGGGCCTCCA TGGACTTGAC 2280
AACAGAGCAT ACGAGATGAC CAAGGTAGCC CATCGAGTCT CCGCGCTGGA AGAACAGCAG 2340
TTCCTGATCA TTCATCCCAC TGCCGATGAA AAAATTCATT TCCAGCACAC AGCAGAACTC 2400
ATTACACAAC TAATTAGGGG AAAGGCTAAT TACAGCTTAC AGATTTACCC GGACGAAAGC 2460
CATTACTTTA CCAGCTCCAG CCTCAAACAG CATCTGTACC GGTCCATCAT CAACTTCTTC 2S20
GTGGAATGCT TCAGGATCCA GGACAAACTG CCGACAGTCA CAGCGAAAGA GGACGAGGAG 2580
GAGGACTAAG CTCAGGTCGC TCTAAGCACA AACGTGGCTC TTTCTACAAC CAGATGCAAC 2640
CGAGGGATTT CCCTGCCCTC CCTCTTCCCT CGGAGGGGCG GGGCGGGGCG GGGCCGGGTG 2700
TTCCATAGCA TGTGTGTCTC GGATGCGGAA GGCAGTTTTG CTTGGGAAAC AAGCTCCTTC 2760
CCCGGGGTCA TCACTCACGG CCTCCATGGC ACCAGGGACA ACGCTGTCCC CGCAGCAGCG 2820
CCTCCTCCCG GCGCCCGAGA GACCGGCACG CCACGGCCCC TCCCCCAAGG AACAGAGCAA 2880
AGGATGGTGG CCGCAGGCCC CACGCGAGCC CACAGGACAC CGGCCCCTAG ATTCCAGCCA 2940
CCAAGCGGAA GCATGAGACC CGCCCACACT AGCCTCTGTG TTCCCGTTAG GGACATCACA 3000
CCCTGTCTCA CGTCGCAGTG CCATGGACGC AGCAGTTACA GCACCATTGT TTTAGCAGTG 3060
CGTGTTCATA TATGGGCTTG CTACTTCCTG TAATGAGGAC GTTCAACATG GTGAGGGGCT 3120
ACAAGAAAAC GCTTTTCTGT ACAGAGTCTT ACTGTAGCTA CGCTAATGGT TAACCTGATA 3180
GAATTAACTC GTATTTTTCT ATGGTTTTAA CCTGATGCTC CACTGTCTCC GTCATGGGGT 3240
TGTTTTGCTG TTTGGGGTTG GGCCTTGTTT CCCTTTCCTT TCTCCAGTCC ACGTGTAGAC 3300
TTTGCGCTTG ATGAAGAAGC AGATCG AAG TAACTGCTCC CTCCTCAAGG TTGTCTTCAG 3360
ACGTCTTGGG GACGTTCCTA AACACTGAGG GGGAAGACAG CCAATAGCAC CCATTAAAAG 3420
AAATACCTAA ATAAAACCTC TCTCCCACTC AGCTATGCTA GGGCTTGGCT GTAGGTGTGC 3480
ACTGTCTATT TACATCCGTC CTTACAACCA TCCTTGTCCT CCTTGGTACC GTATCAAGCT 3S40
CTTTCCCATG ACATTTGGTT 3560
Seq ID NO 152 DNA Sequence
Nucleic Acid Accession # XM_087461 1
Coding sequence 236 1138
1 11 21 31 41 51
I I I I I I
CCGCCGCCGG GGGCGGCGGG GAACCCCAAA CGCAACCGGG TCTGGAGGGA TCCCCGCGCC 60
GAGCCAGCCG CCGTCACCGC CTCCGCGCCG CCCCTGCCCG CTTGGCAGGC GCCCGGCGCG 120
CCCGCACTGC GCCCGCCCGC CCCCTCCCGC GGTCCCACCG TGAGCTCGCC GGCCCGTCGC 180
CCGCTCGCCA TGCAACCGCC GCCGGCCTCG CGCGCGTAGG CGCCCGCCGC AGGCCATGCT 240
GCCCCTGCTC GCCGCGCTCC TCCCCGCCGC CTGCCCGCTG CCGCCCGTCC GCGGCGGGGC 300
CGCGGACGCG CCCGGCCTCC TCGGGGTGCC CTCCAATGCT TCAGTCAACG CGTCCTCCGC 360
GGCGAGCCCA TCGCCCCGCG GCTGCTGGCC TCGGCGGCCC CCGGGCCCCC CGAGCGCCCG 420
GGCCCGGAGG AGGCGCCGGC GGCGGCGGCG CCTGTGCAAC ATCAGCGTGC AGCGCCAGAT 480
GCTGAGCTCG CTGCTCGTGC GCTGGGGCCG CCCGCGGGGC TTCCAGTGCG ACCTACTGCT 540
CTTCTCCACC AACGCGCACG GCCGCGCTTT CTTCGCCGCC GCCTTCCACC GCGTCGGGCC 600
GCCGCTGCTC ATCGAGCACC TGGGGCTGGC GGCGGGCGGC GCGCAGCAGG ACCTGCGCCT 660
CTGCGTGGGC TGCGGCTGGG TGCGCCCTCG CCGCACCGGC CGCCTCCGGC CCGCCGCCGC 720
CCCCAGCGCC GCCGCCGCCA CCGCCGGGGC GCCCACCGCG CTGCCAGCCT ACCCCGCGGC 780
CGAGCCGCCC GGGCCGCTGT GGCTGCAGGG CGAGCCGCTG CATTTCTGCT GCCTAGACTT 840
CAGCCTGGAG GAGCTGCAGG GCGAGCCCCG CTGGCGGCTG AACCGTAAGC CCATTGAGTC 900
CACGCTGGTG GCCTGCTTCA TGACCCTCCT CATCGTGGTG TGGAGCGTGG CCGCCCTCAT 960
CTGCCCGCTG CCCATCATCG CCGGCTTCCT GCCCAACGGC ATGGAACAGC GCCCCACCAC 1020
CGCCAGCACC ACCGCAGCCA CCCCCGCCGC AGTGCCCGCA GGGACCACCG CAGCCGCCGC 1080
CGCCGCCGCC GCTGCCGCCG CCGCCGCGGC CGTCACTTCG GGGGTGGCGA CCAAGTGACC 1140
CGCTCCGCTC CTCCCTGTGT CCGTCCTGTG TCCGCGCGCG CGGGTGCCTT TCCCGCCGGA 1200
GACTCGGCCG GTGTGCTTCG TGCTGTAGTT ATCGTTAGTT CCTCTTCCCG AGATGGGGCC 1260
GCCGAGAGAC CCCAGCGCCT TTGAAAAGCA AGGTTTGTGC TGCGCTTCCA GTTCCGAAAA 1320
GCAGATGTTT AAGCCCTTCC ACTGAGGGTG GGATCGCAGC TCCGAAGACG GAGAGGAGGG 1380
AAATGGGGCC CTTTCCCCTC TATTGCATCC CCCTGCCCGA CTCCTTCCCC GCACCCACGT 1440
GCCCTAGATT CATGGCAGAA AATGACCAAA TCCTGTGTAT TTGTTTTATA TATTTAATAA 1500
CTGTTTTAAA TGAAAGTTTT AGTAAAAAAA ATACAAAACA AAAAGATTAA ATTGCTATTG 1560
CTGTAGTAAG AGAAGCTCTT TGTATCTGAA CATAGTTGTA TTTGAAATTT GTGGTTTTTT 1620
AATTTATTTA AAATTGGGGG GAGGGCATGG GAAGGATTTA ACACCGATAT ATTGTTACCG 1680
CTGAAAATGA ACTTTATGAA CCTTTTCCAA GTTGATCTAT CCAGTGACGT GGCCTGGTGG 1740
GCGTTTCTTC TTGTACTTAT GTGGTTTTTT GGCTTTTAAT ACAGACATTT TCCTCC 1796
Seq ID NO 153 DNA Sequence
Nucleic Acid Accession It NM_012261 1
Coding sequence 1-843
1 11 21 31 41 51
I I I I I I
ATGGATCTCC AAGGAAGAGG GGTCCCCAGC ATCGACAGAC TTCGAGTTCT CCTGATGTTG 60
TTCCATACAA TGGCTCAAAT CATGGCAGAA CAAGAAGTGG AAAATCTCTC AGGCCTTTCC 120
ACTAACCCTG AAAAAGATAT ATTTGTGGTG CGGGAAAATG GGACGACGTG TCTCATGGCA 180
GAGTTTGCAG CCAAATTTAT TGTACCTTAT GATGTGTGGG CCAGCAACTA CGTAGATCTG 240
ATCACAGAAC AGGCCGATAT CGCATTGACC CGGGGAGCTG AGGTGAAGGG CCGCTGTGGC 300
CACAGCCAGT CGGAGCTGCA AGTGTTCTGG GTGGATCGCG CATATGCACT CAAAATGCTC 360
TTTGTAAAGG AAAGCCACAA CATGTCCAAG GGACCTGAGG CGACTTCCAG GCTGAGCAAA 420
GTGCAGTTTG TCTACGACTC CTCCCAGAAA ACCCACTTCA AAGACGCAGT CAGTGCTGGG 480
AAGCACACAG CCAACTCGCA CCACCTCTCT GCCTTGGTCA CCCCCGCTGG GAAGTCCTAT 540
GAGTGTCAAG CTCAACAAAC CATTTCACTG GCCTCTAGTG ATCCGCAGAA GACCCTCACC 600 ATGATCCTGT CTGCGGTCCA CATCCAACCT TTTGACATTA TCTCAGATTT TGTCTTCAGT 660
GAAGAGCATA AATGCCCAGT GGATGAGCGG GAGCAACTGG AAGAAACCTT GCCCCTGATT 720
TTGGGGCTCA TCTTGGGCCT CGTCATCATG GTAACACTCG CGATTTACCA CGTCCACCAC 780
AAAATGACTG CCAACCAGGT GCAGATCCCT CGGGACAGAT CCCAGTATAA GCACATGGGC 840
TAG 843
Seq ID NO: 154 DNA Sequence
Nucleic Acid Accession tt : NM_144586
Coding sequence. 261..686
1 11 21 31 41 51
I I I I I I
GGCACGAGGC CGGAGGCGCG GTGCTCGGCC CGGGAGCGCG AGCGGGAGGA GCAGAGACCC 60
GCAGCCGGGA GCCCGAGCGC GGGCGATGCA GGCTCCGCGA GCGGCACCTG CGGCTCCTCT 120
AAGCTACGAC CGTCGTCTCC GCGGCAGCAG CGCGGGCCCC AGCAGCCTCG GCAGCCACAG 180
CCGCTGCAGC CGGGGCAGCC TCCGCTGCTG TCGCCTCCTC TGATGCGCTT GCCCTCTCCC 240
GGCCCCGGGA CTCCGGGAGA ATGTGGGTCC TAGGCATCGC GGCAACTTTT TGCGGATTGT 300
TCTTGCTTCC AGGCTTTGCG CTGCAAATCC AGTGCTACCA GTGTGAAGAA TTCCAGCTGA 360
ACAACGACTG CTCCTCCCCC GAGTTCATTG TGAATTGCAC GGTGAACGTT CAAGACATGT 420
GTCAGAAAGA AGTGATGGAG CAAAGTGCCG GGATCATGTA CCGCAAGTCC TGTGCATCAT 480
CAGCGGCCTG TCTCATCGCC TCTGCCGGGT ACCAGTCCTT CTGCTCCCCA GGGAAACTGA 540
ACTCAGTTTG CATCAGCTGC TGCAACACCC CTCTTTGTAA CGGGCCAAGG CCCAAGAAAA 600
GGGGAAGTTC TGCCTCGGCC CTCAGGCCAG GGCTCCGCAC CACCATCCTG TTCCTCAAAT 660
TAGCCCTCTT CTCGGCACAC TGCTGAAGCT GAAGGAGATG CCACCCCCTC CTGCATTGTT 720
CTTCCAGCCC TCGCCCCCAA CCCCCCACCT CCCTGAGTGA GTTTCTTCTG GGTGTCCTTT 780
TATTCTGGGT AGGGAGCGGG AGTCCGTGTT CTCTTTTGTT CCTGTGCAAA TAATGAAAGA 840
GCTCGGTAAA GCATTCTGAA TAAATTCAGC CTGACTGAAT TTTCAGTATG TACTTGAAGG 900
AAGGAGGTGG AGTGAAAGTT CACCCCCAAA AAAAAAAAAA AAAAAA 946
Seq ID NO : 1SS DNA Sequence
Nucleic Acid Accession If : NM_004694
Coding sequence - 166 . . 1737
1 11 21 31 41 51
I I I I I I
TTGGGGGTTT ATTCTCTTCC CTTCTAACTT GACAGGGTCT TGCTCTGTCA TTCAGGCAAG 60
AGTGCAGTAG TGTGATCACT TCTTACTGCC GCCTCAAGCT TCCAGCCTCA ACTCAAGCAA 120
TCCTCCCACC TCAGCCACCC AAGTGGCTGG GACTACAGAT TAAGAATGAC CCAAAATAAA 180
TTAAAGCTTT GTTCCAAAGC CAATGTGTAT ACTGAAGTGC CTGATGGAGG ATGGGGCTGG 240
GCGGTAGCTG TTTCATTTTT CTTCGTTGAA GTCTTCACCT ACGGCATCAT CAAGACATTT 300
GGTGTCTTCT TTAATGACTT AATGGACAGT TTTAATGAAT CCAATAGCAG GATCTCATGG 360
ATAATCTCAA TCTGTGTGTT TGTCTTAACA TTTTCAGCTC CCCTCGCCAC AGTCCTGAGC 420
AATCGTTTCG GACACCGTCT GGTAGTGATG TTGGGGGGGC TACTTGTCAG CACCCCGATG 480
GTGGCCGCCT CCTTCTCACA AGAGGTTTCT CATATGTACG TCGCCATCGG CATCATCTCT 540
GGTCTGGGAT ACTGCTTTAG TTTTCTCCCA ACTGTAACCA TCCTATCACA ATATTTTGGC 600
AAAAGACGTT CCATAGTCAC TGCAGTTGCT TCCACAGGAG AATGTTTCGC TGTGTTTGCT 660
TTCGCACCAG CAATCATGGC TCTGAAGGAG CGCATTCCCT GGAGATACAG CCTCCTCTTC 720
GTGGGCCTAC TACAGTTAAA CATTGTCATC TTCGGAGCAC TGCTCAGACC CATCATTATC 780
AGAGGACCAG CGTCACCGAA AATAGTCATC CAGGAAAATC GGAAAGAAGC GCAGTATATG 840
CTTGAAAATG AGAAAACACG AACCTCAATA GACTCCATTG ACTCAGGAGT AGAACTAACT 900
ACCTCACCTA AAAATGTGCC TACTCACACT AACCTGGAAC TGGAGCCGAA GGCCGACATG 960
CAGCAGGTCC TGGTGAAGAC CAGCCCCAGC CCAAGCGAAA AGAAAGCCCC GCTATTAGAC 1020
TTCTCCATTT TGAAAGAGAA AAGTTTTATT TGTTATGCAT TATTTGGTCT CTTTGCAACA 1080
CTGGGATTCT TTGCACCTTC CTTGTACATC ATTCCTCTGG GCATTAGTCT GGGCATTGAC 1140
CAGGACCGCG CTGCTTTTTT ATTATCTACG ATGGCCATTG CAGAAGTTTT CGGAAGGATC 1200
GGAGCTGGTT TTGTCCTCAA CAGCGAGCCC ATTCGTAAGA TTTACATTGA GCTCATCTGC 1260
GTCATCTTAT TGACTGTGTC TCTGTTTGCC TTTACTTTTG CTACTGAATT CTGGGGTCTA 1320
ATGTCATGCA GCATATTTTT TGGGTTTATG GTTGGAACAA TAGGAGGACT CACATTCCAC 1380
TGCTTGCTGA AGATGATGTC GTGGGCATTG CAGAAGATGT CTTCTGCAGC TGGGGTCTAC 1440
ATCTTCATTC AGAGCATAGC AGGACTGGCT GGACCGCCCC TTGCAGGTTT GTTGGTGGAC 1500
CAAAGTAAGA TCTACAGCAG GGCCTTCTAC TCCTGCGCAG CTGGCATGGC CCTGGCTGCT 1560
GTGTGCCTCG CCCTGGTGAG ACCGTGTAAG ATGGGACTGT GCCAGCGTCA TCACTCAGGT 1620
GAAACAAAGG TAGTGAGCCA TCGTGGGAAG ACTTTACAGG ACATACCTGA AGACTTTCTG 1680
GAAATGGATC TTGCAAAAAA TGAGCACAGA GTTCACGTGC AAATGGAGCC GGTATGACAC 1740
ACTTTCTTAC AACAACAGCC ACTGTGTTGG CTGGAGAGGG ATGGGGTGGG CCCAACGGGG 1800
ACACAAGGAG GCAGAGGAGC TAACCCCTCT ACTCCACTTT CAAAACTACA TTTTAAAGGG 1860
AATGTGTATG TGAAGAGCAC TACCAACATC GCTTTTGTTT TGTTTTGTTT TGTTTTAAGC 1920
TTTTTTTTTT TGCTTGTTTT TAAAGCCAAA ACAAAAAACA ACCAAGCACT CTTCCATATA 1980
TAAATCTGCC TGTATTCAGT AGCAATACAA GAGATATGTA GAAAGACTCT TTGGTTCACA 2040
TTCCGATATT AAAATAGTGA CATGAACTGG CAAAGTGGTT TTAAAAGCTT TCACGTGGGA 2100
TAAATGATTT TCTTTTTTTC TTTTCTTTCT TCCTATCCTC TTGTCTGAAT AAACTACTCT 2160
CCTGAATAAA ACAACATCCA ACCCAGGTCA TTGAAATGAA ATTGGCCAGT C . 2212
Seq ID NO : 156 DNA Sequence
Nucleic Acid Accession It : NM_004833 . 1
Coding sequence : 246 . . 1277
1 11 21 31 41 51
I I I I I I
TCAGCCAATT AGAGCTCCAG TTGTCACTCC TACCCACACT GGGCCTGGGG GTGAAGGGAA 60
GTGTTTATTA GGGGTACATG TGAAGCCGTC CAGAAGTGTC AGAGTCTTTG TAGCTTTGAA 120
AGTCACCTAG GTTATTTGGG CATGCTCTCC TGAGTCCTCT GCTAGTTAAG CTCTCTGAAA 180
AGAAGGTGGC AGACCCGGTT TGCTGATCGC CCCAGGGATC AGGAGGCTGA TCCCAAAGTT 240
GTCAGATGGA GAGTAAATAC AAGGAGATAC TCTTGCTAAC AGGCCTGGAT AACATCACTG 300
ATGAGGAACT GGATAGGTTT AAGTTCTTTC TTTCAGACGA GTTTAATATT GCCACAGGCA 360
AACTACATAC TGCAAACAGA ATACAAGTAG CTACCTTGAT GATTCAAAAT GCTGGGGCGG 420
TGTCTGCAGT GATGAAGACC ATTCGTATTT TTCAGAAGTT GAATTATATG CTTTTGGCAA 480 AACGTCTTCA GGAGGAGAAG GAGAAAGTTG ATAAGCAATA CAAATCGGTA ACAAAACCAA 540
AGCCACTAAG TCAAGCTGAA ATGAGTCCTG CTGCATCTGC AGCCATCAGA AATGATGTCG 600
CAAAGCAACG TGCTGCACCA AAAGTCTCTC CTCATGTTAA GCCTGAACAG AAACAGATGG 660
TGGCCCAGCA GGAATCTATC AGAGAAGGGT TTCAGAAGCG CTGTTTGCCA GTTATGGTAC 720
TGAAAGCAAA GAAGCCCTTC ACGTTTGAGA CCCAAGAAGG CAAGCAGGAG ATGTTTCATG 780
CTACAGTGGC TACAGAAAAG GAATTCTTCT TTGTAAAAGT TTTTAATACA CTGCTGAAAG 840
ATAAATTCAT TCCAAAGAGA ATAATTATAA TAGCAAGATA TTATCGGCAC AGTGGTTTCT 900
TAGAGGTAAA TAGCGCCTCA CGTGTGTTAG ATGCTGAATC TGACCAAAAG GTTAATGTCC 960
CGCTGAACAT TATCAGAAAA GCTGGTGAAA CCCCGAAGAT CAACACGCTT CAAACTCAGC 1020
CCCTTGGAAC AATTGTGAAT GGTTTGTTTG TAGTCCAGAA CCTAACAGAA AAGAAGAAAA 1080
ACATATTATT TGACCTAAGT GACAACACTG GGAAAATGGA AGTACTGGGG GTTAGAAACG 1140
AGGACACAAT GAAATGTAAG GAAGGAGATA AGGTTCGACT TACATTCTTC ACACTGTCAA 1200
AAAATGGAGA AAAACTACAG CTGACATCTG GAGTTCATAG CACCATAAAG GTTATTAAGG 1260
CCAAAAAAAA AACATAGAGA AGTAAAAAGG ACCAATTCAA GCCAACTGGT CTAAGCAGCA 1320
TTTAATTGAA GAATATGTGA TACAGCCTCT TCAATCAGAT TGTAAGTTAC CTGAAAGCTG 1380
CAGTTCACAG GCTCCTCTCT CCACCAAATT AGGATAGAAT AATTGCTGGA TAAACAAATT 1440
CAGAATATCA ACAGATGATC ACAATAAACA TCTGTTTCTC ATTCC 1485
Seq ID NO: 157 DNA Sequence
Nucleic Acid Accession #: NM_00S409.3
Coding sequence: 94.-378
1 11 21 31 41 51
I I I I I I
TTCCTTTCAT GTTCAGCATT TCTACTCCTT CCAAGAAGAG CAGCAAAGCT GAAGTAGCAG 60
CAACAGCACC AGCAGCAACA GCAAAAAACA AACATGAGTG TGAAGGGCAT GGCTATAGCC 120
TTGCCTGTGA TATTGTGTGC TACAGTTGTT CAAGGCTTCC CCATGTTCAA AAGAGGACGC 180
TGTCTTTGCA TAGGCCCTGG GGTAAAAGCA GTGAAAGTGG CAGATATTGA GAAAGCCTCC 240
ATAATGTACC CAAGTAACAA CTGTGACAAA ATAGAAGTGA TTATTACCCT GAAAGAAAAT 300
AAAGGACAAC GATGCCTAAA TCCCAAATCG AAGCAAGCAA GGCTTATAAT CAAAAAAGTT 360
GAAAGAAAGA ATTTTTAAAA ATATCAAAAC ATATGAAGTC CTGGAAAAGG GCATCTGAAA 420
AACCTAGAAC AAGTTTAACT GTGACTACTG AAATGACAAG AATTCTACAG TAGGAAACTG 480
AGACTTTTCT ATGGTTTTGT GACTTTCAAC TTTTGTACAG TTATGTGAAG GATGAAAGGT 540
GGGTGAAAGG ACCAAAAACA GAAATACAGT CTTCCTGAAT GAATGACAAT CAGAATTCCA 600
CTGCCCAAAG GAGTCCAGCA ATTAAATGGA TTTCTAGGAA AAGCTACCTT AAGAAAGGCT 660
GGTTACCATC GGAGTTTACA AAGTGCTTTC ACGTTCTTAC TTGTTGTATT ATACATTCAT 720
GCATTTCTAG GCTAGAGAAC CTTCTAGATT TGATGCTTAC AACTATTCTG TTGTGACTAT 780
GAGAACATTT CTGTCTCTAG AAGTTATCTG TCTGTATTGA TCTTTATGCT ATATTACTAT 840
CTGTGGTTAC AGTGGAGACA TTGACATTAT TACTGGAGTC AAGCCCTTAT AAGTCAAAAG 900
CATCTATGTG TCGTAAAGCA TTCCTCAAAC ATTTTTTCAT GCAAATACAC ACTTCTTTCC 960
CCAAATATCA TGTAGCACAT CAATATGTAG GGAAACATTC TTATGCATCA TTTGGTTTGT 1020
TTTATAACCA ATTCATTAAA TGTAATTCAT AAAATGTACT ATGAAAAAAA TTATACGCTA 1080
TGGGATACTG GCAACAGTGC ACATATTTCA TAACCAAATT AGCAGCACCG GTCTTAATTT 1140
GATGTTTTTC AACTTTTATT CATTGAGATG TTTTGAAGCA ATTAGGATAT GTGTGTTTAC 1200
TGTACTTTTT GTTTTGATCC GTTTGTATAA ATGATAGCAA TATCTTGGAC ACATTTGAAA 1260
TACAAAATGT TTTTGTCTAC CAAAGAAAAA TGTTGAAAAA TAAGCAAATG TATACCTAGC 1320
AATCACTTTT ACTTTTTGTA ATTCTGTCTC TTAGAAAAAT ACATAATCTA ATCAATTTCT 1380
TTGTTCATGC CTATATACTG TAAAATTTAG GTATACTCAA GACTAGTTTA AAGAATCAAA 1440
GTCATTTTTT TCTCTAATAA ACTACCACAA CCTTTCTTTT TTAAAAAAAA AAA 1493
Seq ID NO: DNA Sequence 158
Nucleic Acid Accession ft: NM_002562.1
Coding sequence: 27..1814
1 11 21 31 41 51
I I I I I I
AAAACGCAGG GAGGGAGGCT GTCACCATGC CGGCCTGCTG CAGCTGCAGT GATGTTTTCC 60
AGTATGAGAC GAACAAAGTC ACTCGGATCC AGAGCATGAA TTATGGCACC ATTAAGTGGT 120
TCTTCCACGT GATCATCTTT TCCTACGTTT GCTTTGCTCT GGTGAGTGAC AAGCTGTACC 180
AGCGGAAAGA GCCTGTCATC AGTTCTGTGC ACACCAAGGT GAAGGGGATA GCAGAGGTGA 240
AAGAGGAGAT CGTGGAGAAT GGAGTGAAGA AGTTGCTGCA CAGTGTCTTT GACACCGCAG 300
ACTACACCTT CCCTTTGCAG GGGAACTCTT TCTTCGTGAT GACAAACTTT CTCAAAACAG 360
AAGGCCAAGA GCAGCGCTTG TGTCCCGAGT ATCCCACCCG CAGGACGCTC TGTTCCTCTG 420
ACCGAGGTTG TAAAAAGGGA TGGATGGACC CGCAGAGCAA AGGAATTCAG ACCGGAAGGT 480
GTGTAGTGCA TGAAGGGAAC CAGAAGACCT GTGAAGTCTC TGCCTGGTGC CCCATCGAGG 540
CAGTGGAAGA GGCCCCCCGG CCTGCTCTCT TGAACAGTGC CGAAAACTTC ACTGTGCTCA 600
TCAAGAACAA TATCGACTTC CCCGGCCACA ACTACACCAC GAGAAACATC CTGCCAGGTT 660
TAAACATCAC TTGTACCTTC CACAAGACTC AGAATCCACA GTGTCCCATT TTCCGACTAG 720
GAGACATCTT CCGAGAAACA GGCGATAATT TTTCAGATGT GGCAATTCAG GGCGGAATAA 780
TGGGCATTGA GATCTACTGG GACTGCAACC TAGACCGTTG GTTCCATCAC TGCCATCCCA 840
AATACAGTTT CCGTCGCCTT GACGACAAGA CCACCAACGT GTCCTTGTAC CCTGGCTACA 900
ACTTCAGATA CGCCAAGTAC TACAAGGAAA ACAATGTTGA GAAACGGACT CTGATAAAAG 960
TCTTCGGGAT CCGTTTTGAC ATCCTGGTTT TTGGCACCGG AGGAAAATTT GACATTATCC 1020
AGCTCCTTGT GTACATCGGC TCAACCCTCT CCTACTTCGG TCTGGCCGCT GTGTTCATCG 1080 ACTTCCTCAT CGACACTTAC TCCAGTAACT GCTGTCGCTC CCATATTTAT CCCTGGTGCA 1140 AGTGCTGTCA GCCCTGTGTG GTCAACGAAT ACTACTACAG GAAGAAGTGC GAGTCCATTG 1200 TGGAGCCAAA GCCGACATTA AAGTATGTGT CCTTTGTGGA TGAATCCCAC ATTAGGATGG 1260 TGAACCAGCA GCTACTAGGG AGAAGTCTGC AAGATGTCAA GGGCCAAGAA GTCCCAAGAC 1320 CTGCGATGGA CTTCACAGAT TTGTCCAGGC TGCCCCTGGC CCTCCATGAC ACACCCCCGA 1380 TTCCTGGACA ACCAGAGGAG ATACAGCTGC TTAGAAAGGA GGCGACTCCT AGATCCAGGG 1440 ATAGCCCCGT CTGGTGCCAG TGTGGAAGCT GCCTCCCATC TCAACTCCCT GAGAGCCACA 1500 GGTGCCTCCA GGAGCTGTGC TGCCGGAAAA AGCCGGGGGC CTGCATCACC ACCTCAGAGC 1560 TGTTCAGGAA GCTGGTCCTG TCCAGACACG TCCTGCAGTT CCTCCTGCTC TACCACCAGC 1620 CCTTGCTGGC GCTGGATGTG GATTCCACCA ACAGCCGGCT GCGCCACTGT GCCTACAGGT 1680 GCTACGCCAC CTGGCGCTTC GGCTCCCAGG ACATGGCTGA CTTTGCCATC CTGCCCAGCT 1740 GCTGCCGCTG GAGGATCCGG AAAGAGTTTC CGAAGAGTGA AGGGCAGTAC AGTGGCTTCA 1800 AGAGTCCTTA CTGAAGCCAG GCACCGTGGC TCACGTCTGT AATCCCACCT TTT 1853
Seq ID NO 159 DNA Sequence Nucleic Acid Accession II NM_001793 2 Coding sequence 54-2543
1 11 21 31 41 51
I I I I I I
AAAGGGGCAA GAGCTGAGCG GAACACCGGC CCGCCGTCGC GGCAGCTGCT TCACCCCTCT 60
CTCTGCAGCC ATGGGGCTCC CTCGTGCACC TCTCGCGTCT CTCCTCCTTC TCCAGGTTTG 120 CTGGCTGCAG TGCGCGGCCT CCGAGCCGTG CCGGGCGGTC TTCAGGGAGG CTGAAGTGAC 180
CTTGGAGGCG GGAGGCGCGG AGCAGGAGCC CGGCCACCCG CTGGGGAAAG TATTCATCCG 240
CTGCCCTGGG CAAGAGCCAG CTCTGTTTAG CACTGATAAT GATGACTTCA CTGTGCGGAA 300
TGGCGAGACA GTCCAGGAAA GAAGGTCACT GAAGGAAAGG AATCCATTGA AGATCTTCCC 360
ATCCAAACGT ATCTTACGAA GACACAAGAG AGATTGGGTG GTTGCTCCAA TATCTGTCCC 420 TGAAAATGGC AAGGGTCCCT TCCCCCAGAG ACTGAATCAG CTCAAGTCTA ATAAAGATAG 480
AGACACCAAG ATTTTCTACA GCATCACGCG GCCGGGGGCA GACAGCCCCC CTGAGGGTGT 540
CTTCGCTGTA GAGAAGGAGA CAGGCTGGTT GTTGTTGAAT AAGCCACTGG ACCGGGAGGA 600
GATTGCCAAG TATGAGCTCT TTGGCCACGC TGTGTCAGAG AATGGTGCCT CAGTGGAGGA 660
CCCCATGAAC ATCTCCATCA TCGTGACCGA CCAGAATGAC CACAAGCCCA AGTTTACCCA 720 CCACACCTTC CGAGCCAGTG TCTTAGAGGG AGTCCTACCA GGTACTTCTG TGATGCACCT 780
GACAGCCACG GATGAGGATG ATGCCATCTA CACCTACAAT GGGGTGGTTG CTTACTCCAT 840
CCATAGCCAA GAACCAAAGG ACCCACACGA CCTCATGTTC ACCATTCACC GGAGCACACC 900
CACCATCAGC GTCATCTCCA GTGGCCTGGA CCGGGAAAAA GTCCCTGAGT ACACACTGAC 960
CATCCAGGCC ACAGACATGG ATGGGGACGG CTCCACCACC ACGGCAGTGG CAGTAGTGGA 1020 GATCCTTGAT GCCAATGACA ATGCTCCCAT GTTTGACCCC CAGAAGTACG AGGCCCATGT 1080
GCCTGAGAAT GCAGTGGGCC ATGAGGTGCA GAGGCTGACG GTCACTGATC TGGACGCCCC 1140
CAACTCACCA GCGTGGCGTG CCACCTACCT TATCATGGGC GGTGACGACG GGGACCATTT 1200
TACCATCACC ACCCACCCTG AGAGCAACCA GCGCATCCTG ACAACCAGGA AGGGTTTGGA 1260
TTTTGAGGCC AAAAACCAGC ACACCCTGTA CGTTGAAGTG ACCAACGAGG CCCCTTTTGT 1320 GCTGAAGCTC CCAACCTCCA CAGCCACCAT AGTGGTCCAC GTGGAGGATG TGAATGAGGC 1380
ACCTGTGTTT GTCCCACCCT CCAAAGTCGT TGAGGTCCAG GAGGGCATCC CCACTGGGGA 1440
GCCTGTGTGT GTCTACACTG CAGAAGACCC TGACAAGGAG AATCAAAAGA TCAGCTACCG 1SO0
CATCCTGAGA GACCCAGCAG GGTGGCTAGC CATGGACCCA GACAGTGGGC AGGTCACAGC 1560
TGTGGGCACC CTCGACCGTG AGGATGAGCA GTTTGTGAGG AACAACATCT ATGAAGTCAT 1620 GGTCTTGGCC ATGGACAATG GAAGCCCTCC CACCACTGGC ACGGGAACCC TTCTGCTAAC 1680
ACTGATTGAT GTCAATGACC ATGGCCCAGT CCCTGAGCCC CGTCAGATCA CCATCTGCAA 1740
CCAAAGCCCT GTGCGCCAGG TGCTGAACAT CACGGACAAG GACCTGTCTC CCCACACCTC 1800
CCCTTTCCAG GCCCAGCTCA CAGATGACTC AGACATCTAC TGGACGGCAG AGGTCAACGA 1860
GGAAGGTGAC ACAGTGGTCT TGTCCCTGAA GAAGTTCCTG AAGCAGGATA CATATGACGT 1920 GCACCTTTCT CTGTCTGACC ATGGCAACAA AGAGCAGCTG ACGGTGATCA GGGCCACTGT 1980
GTGCGACTGC CATGGCCATG TCGAAACCTG CCCTGGACCC TGGAAGGGAG GTTTCATCCT 2040
CCCTGTGCTG GGGGCTGTCC TGGCTCTGCT GTTCCTCCTG CTGGTGCTGC TTTTGTTGGT 2100
GAGAAAGAAG CGGAAGATCA AGGAGCCCCT CCTACTCCCA GAAGATGACA CCCGTGACAA 2160
CGTCTTCTAC TATGGCGAAG AGGGGGGTGG CGAAGAGGAC CAGGACTATG ACATCACCCA 2220 GCTCCACCGA GGTCTCCAGG CCAGGCCGGA GGTGGTTCTC CGCAATGACG TGGCACCAAC 2280
CATCATCCCG ACACCCATGT ACCGTCCTCG GCCAGCCAAC CCAGATGAAA TCGGCAACTT 2340
TATAATTGAG AACCTGAAGG CGGCTAACAC AGACCCCACA GCCCCGCCCT ACGACACCCT 2400
CTTGGTGTTC GACTATGAGG GCAGCCCCTC CGACGCCGCG TCCCTGAGCT CCCTCACCTC 2460
CTCCGCCTCC GACCAAGACC AAGATTACGA TTATCTGAAC GAGTGGGGCA GCCGCTTCAA 2520 GAAGCTGGCA GACATGTACG GTGGCGGGGA GGACGACTAG GCGGCCTGCC TGCAGGGCTG 2580
GGGACCAAAC GTCAGGCCAC AGAGCATCTC CAACCGGTCT CAGTTCCCCC TTCAGCTGAG 2640
GACTTCGGAG CTTGTCAGGA AGTGGCCGTA GCAACTTGGC GGAGACAGGC TATGAGTCTG 2700
ACGTTAGAGT GGTTGCTTCC TTAGCCTTTC AGGATGGAGG AATGTGGGCA GTTTGACTTC 2760
AGCACTGAAA ACCTCTCCAC CTGGGCCAGG GTTGCCTCAG AGGCCAAGTT TCCAGAAGCC 2820 TCTTACCTGC CGTAAAATGC TCAACCCTGT GTCCTGGGCC TGGGCCTGCT GTGACTGACC 2880
TACAGTGGAC TTTCTCTCTG GAATGGAACC TTCTTAGCCC TCCTGGTGCA ACTTAATTTT 2940
TTTTTTTAAT GCTATCTTCA AAACGTTAGA GAAAGTTCTT CAAAAGTGCA GCCCAGAGCT 3000
GCTCCGCCCA CTGGCCGTCC TGCATTTCTG GTTTCCAGAC CCCAATGCCT CCCATTCGGA 3060
TGGATCTCTG CGTTTTTATA CTGAGTGTGC CTAGGTTGCC CCTTATTTTT TATTTTCCCT 3120 GTTGCGTTGC TATAGATGAA GGGTGAGGAC AATCGTGTAT ATGTACTAGA ACTTTTTTAT 3180
TAAAGAAACT TTTCCCAGAA AAAAA 3205
Seq ID NO 160 DNA Sequence
Nucleic Acid Accession tt NM_002571 1
Coding sequence 99 587
1 11 21 31 41 51
I I I I I I
CATCCCTCTG GCTCCAGAGC TCAGAGCCAC CCACAGCCGC AGCCATGCTG TGCCTCCTGC 60
TCACCCTGCG CGTGGCCCTG GTCTGTGGTG TCCCGGCCAT GGACATCCCC CAGACCAAGC 120
AGGACCTGGA GCTCCCAAAG TTGGCAGGGA CCTGGCACTC CATGGCCATG GCGACCAACA 180
ACATCTCCCT CATGGCGACA CTGAAGGCCC CTCTGAGGGT CCACATCACC TCACTGTTGC 240
CCACCCCCGA GGACAACCTG GAGATCGTTC TGCACAGATG GGAGAACAAC AGCTGTGTTG 00
AGAAGAAGGT CCTTGGAGAG AAGACTGGGA ATCCAAAGAA GTTCAAGATC AACTATACGG 360
TGGCGAACGA GGCCACGCTG CTCGATACTG ACTACGACAA TTTCCTGTTT CTCTGCCTAC 420
AGGACACCAC CACCCCCATC CAGAGCATGA TGTGCCAGTA CCTGGCCAGA GTCCTCCTGG 480
AGGACGATGA GATCATGCAG GGATTCATCA GGGCTTTCAG GCCCCTGCCC AGGCACCTAT 540
GGTACTTGCT GGACTTGAAA CAGATGGAAG AGCCGTGCCG TTTCTAGCTC ACCTCCGCCT 600
CCAGGAAGAC CAGACTCCCA CCCTTCCACA CCTCCAGAGC AGTGGGACTT CCTCCTGCCC 660
TTTCAAAGAA TAACCACAGC TCAGAAGACG ATGACGTGGT CATCTGTGTC GCCATCCCCT 720
TCCTGCTGCA CACCTGCACC ATTGCCATGG GGAGGCTGCT CCCTGCCGGC AGAGTCTCTG 780
GCAGAGGTTA TTAATAAACC CTTGGAGCAT G 811
Seq ID NO 161 DNA Sequence
Nucleic Acid Accession It NM 001327 1 Coding sequence 89 631
1 11 21 31 41 51
I I I I I I
AGCAGCGGGC GCTGTGTGTA CCGAGAATAC GAGAATACCT CGTGGGCCCT GACCTTCTCT 60
CTGAGAGCCG GGCAGAGGCT CCGGAGCCAT GCAGGCCGAA GGCCGGGGCA CAGGGGGTTC 120
GACGGGCGAT GCTGATGGCC CAGGAGGCCC TGGCATTCCT GATGGCCCAG GGGGCAATGC 180
TGGCGGCCCA GGAGAGGCGG GTGCCACCCG CCCCAGAGGT CCCCCCGGCG CAGGGGCAGC 240
AAGGGCCTCG GGGCCGGGAG GAGGCGCCCC GCGGGGTCCG CATCCCGCCG CGGCTTCAGG 300
GCTGAATGGA TGCTGCAGAT GCGGGGCCAG GGGGCCGGAG AGCCGCCTGC TTGAGTTCTA 360
CCTCGCCATG CCTTTCGCGA CACCCATGGA AGCAGAGCTG GCCCGCAGGA GCCTCCCCCA 420
GGATGCCCCA CCGCTTCCCG TGCCACCGGT GCTTCTGAAG GAGTTCACTG TGTCCGGCAA 480
CATACTGACT ATCCGACTGA CTGCTGCAGA CCACCGCCAA CTGCAGCTCT CCATCAGCTC 540
CTGTCTCCAG CAGCTTTCCC TGTTGATGTG GATCACGCAG TGCTTTCTGC CCGTGTTTTT 600
GGCTCAGCCT CCCTCAGGGC AGAGGCGCTA AGCCCAGCCT GGCGCCCCTT CCTAGGTCAT 660
GCCTCCTCCC CTACCGAATG GTCCCAGCAC GAGTGGCCAG TTCATTGTGG GGGCCTGATT 720
GTTTGTCGCT GGAGGAGGAC GGCTTACATG TTTGTTTCTG TAGAAAATAA AACTGAGCTA 780
Seq ID NO: 162 DNA Sequence Nucleic Acid Accession « NM_020994 Coding sequence 53 459
1 11 21 31 41 51
I I I I I I
CCTCGTGGGC CCTGACCTTC TCTCTGAGAG CCGGGCAGAG GCTCCGGAGC CATGCAGGCC 60
GAAGGCCAGG GCACAGGGGG TTCGACGGGC GATGCTGATG GCCCAGGAGG CCCTGGCATT 120 CCTGATGGCC CACCGGGCAA TGCTGGCGGC CCAGCAGAGG CGGGTGCCAC GGGCGGCAGA 180
GGTCCCCGGG GCGCAGGGGC AGCAAGGGCC TCGGGGCCGA GAGGAGGCGC CCCGCGGGGT 240
CCGCATGGCG GTGCCGCTTC TGCGCACCAT GGAAGGTGCC CCTGCGGGGC CAGGAGGCCG 300
GACAGCCGCC TGCTTCAGTT CCGACTGACT GCTGCAGACC ACCGCCAACT GCAGCTCTCC 360
ATCAGCTCCT GTCTCCAGCA GCTTTCCCTG TTGATGTGGA TCACGCAGTG CTTTCTGCCC 420 GTGTTTTTGG CTCAGCCTCC CTCAGGGCAG AGGCGCTAAG CCCAGCCTGG CGCCCCTTCC 480
TAGGTCATGC CTCCTCCCCT AGGGAATGGT CCCAGCACGA GTGGCCAGTT CATTGTGGGG 540
GCCTGATTGT TTGTCGCTGG AGGAGGACGG CTTACATGTT TGTTTCTGTA GAAAATAAAG 600
CTGAGCTA 608 Seq ID NO- 163 DNA Sequence
Nucleic Acid Accession Ii NM_006928.2
Coding sequence 1 1986
1 11 21 31 41 51
I I I I I I
ATGGATCTGG TGCTAAAAAG ATGCCTTCTT CATTTGGCTG TGATAGGTGC TTTGCTGGCT 60
GTGGGGGCTA CAAAAGTACC CAGAAACCAG GACTGGCTTG GTGTCTCAAG GCAACTCAGA 120
ACCAAAGCCT GGAACAGGCA GCTGTATCCA GAGTGGACAG AAGCCCAGAG ACTTGACTGC 180
TGGAGAGGTG GTCAAGTGTC CCTCAAGGTC AGTAATGATG GGCCTACACT GATTGGTGCA 240
AATGCCTCCT TCTCTATTGC CTTGAACTTC CCTGGAAGCC AAAAGGTATT GCCAGATGGG 300
CAGGTTATCT GGGTCAACAA TACCATCATC AATGGGAGCC AGGTGTGGGG AGGACAGCCA 360
GTGTATCCCC AGGAAACTGA CGATGCCTGC ATCTTCCCTG ATGGTGGACC TTGCCCATCT 420
GGCTCTTGGT CTCAGAAGAG AAGCTTTGTT TATGTCTGGA AGACCTGGGG CCAATACTGG 480
CAAGTTCTAG GGGGCCCAGT GTCTGGGCTG AGCATTGGGA CAGGCAGGGC AATGCTGGGC 540
ACACACACCA TGGAAGTGAC TGTCTACCAT CGCCGGGGAT CCCGGAGCTA TGTGCCTCTT 600
GCTCATTCCA GCTCAGCCTT CACCATTACT GACCAGGTGC CTTTCTCCGT GAGCGTGTCC 660
CAGTTGCGGG CCTTGCATGG AGGGAACAAG CACTTCCTGA GAAATCAGCC TCTGACCTTT 720
GCCCTCCAGC TCCATGACCC CAGTGGCTAT CTGGCTGAAG CTGACCTCTC CTACACCTGG 780
GACTTTGGAG ACAGTAGTGG AACCCTGATC TCTCGGGCAC TTGTGGTCAC TCATACTTAC 840
CTCCAGCCTG GCCCAGTCAC TGCCCAGGTG GTCCTGCAGG CTGCCATTCC TCTCACCTCC 900
TGTGGCTCCT CCCCAGTTCC AGGCACCACA GATGGGCACA GGCCAACTGC AGAGGCCCCT 960
AACACCACAG CTGGCCAAGT GCCTACTACA GAAGTTGTGG GTACTACACC TGGTCAGGCG 1020
CCAACTGCAG AGCCCTCTGG AACCACATCT GTGCAGGTGC CAACCACTGA AGTCATAAGC 1080
ACTGCACCTG TGCAGATGCC AACTGCAGAG AGCACAGGTA TGACACCTGA GAAGGTGCCA 1140
GTTTCAGAGG TCATGGGTAC CACACTGGCA GAGATGTCAA CTCCAGAGGC TACAGGTATG 1200
ACACCTGCAG AGGTATCAAT TGTGGTGCTT TCTGGAACCA CAGCTGCACA GGTAACAACT 1260
ACAGAGTGGG TGGAGACCAC AGCTAGAGAG CTACCTATCC CTGAGCCTGA AGGTCCAGAT 1320
GCCAGCTCAA TCATGTCTAC GGAAAGTATT ACAGGTTCCC TGGGCCCCCT GCTGGATGGT 1380
ACAGCCACCT TAAGGCTGGT GAAGAGACAA GTCCCCCTCC ATTGTGTTCT GTATCGATAT 1440
GGTTCCTTTT CCGTCACCCT GGACATTGTC CAGGGTATTG AAAGTGCCGA GATCCTGCAG 1500
GCTGTGCCGT CCGGTGAGGG GGATGCATTT GAGCTGACTG TGTCCTGCCA AGGCGGGCTG 1S60
CCCAAGGAAG CCTGCATGGA GATCTCATCG CCAGCGTGCC AGCCCCCTGC CCAGCGGCTG 1620
TGCCAGCCTG TGCTACCCAG CCCAGCCTGC CAGCTCCTTC TGCACCAGAT ACTGAAGGGT 1680
GGCTCGGGGA CATACTGCCT CAATGTGTCT CTGGCTGATA CCAACAGCCT GGCAGTGGTC 1740
AGCACCCAGC TTATCATGCC TGGTCAAGAA GCAGGCCTTG GGCAGGTTCC GCTGATCGTG 1800
GGCATCTTGC TGGTGTTGAT GGCTGTCCTC CTTGCATCTC TGATATATAG GCGCAGACTT 1860
ATGAAGCAAG ACTTCTCCGT ACCCCAGTTG CCACATAGCA GCAGTCACTG GCTGCGTCTA 1920
CCCCGCATCT TCTGCTCTTG TCCCATTGGT GAGAATAGCC CCCTCCTCAG TGGGCAGCAG 1980
GTCTGA 1986 Seq ID NO 164 DNA Sequence
Nucleic Acid Accession It NM_001922 2
Coding sequence 415 1974
1 11 21 31 41 51
I I I I I I
GCAATTAAAG TCAAGAGCTA AGGAGGGAGG GAGAGGGTTT AGAAATACCA GCATAATAAG 60
TAGTATGACT CCGTGCTCTG TAAATTAACT CAATTAGACA AAGCCTGACT TAACCCGGGA 120
AGATGGTGAG AAGCGCTACC CTCATTAAAT TTGGTTGTTA GAGGCGCTTC TAAGGAAATT 180
AAGTCTGTTA GTTGTTTGAA TCACATAAAA TTGTGTGTGC ACGTTCATGT ACACATGTGC 240
ACACATGTAA CCTCTGTGAT TCTTGTGGGT ATTTTTTTAA GAAGAAAGGA ATAGAAAGCA 300 AAGAAAAATA AAAAATACTG AAAAGAAAAG ACTGAAAGAG TAGAAGATAA GGAGAAAAGT 360
ACGACAGAGA CAAGGAAAGT AAGAGAGAGA GAGAGCTCTC CCAATTATAA AGCCATGAGC 420
CCCCTTTGGT GGGGGTTTCT GCTCAGTTGC TTGGGCTGCA AAATCCTGCC AGCAGCCCAG 480
GGTCAGTTCC CCCGAGTCTG CATGACGGTG GACAGCCTAG TGAACAAGGA GTGCTGCCCA 540
CGCCTGGGTG CAGAGTCGGC CAATGTCTGT GGCTCTCAGC AAGGCCGGGG GCAGTGCACA 600
GAGGTGCGAG CCGACACAAG GCCCTCCAGT GGTCCCTACA TCCTACGAAA CCAGGATGAC 660
CGTGAGCTGT GGCCAAGAAA ATTCTTCCAC CGGACCTGCA AGTGCACAGG AAACTTTGCC 720
GGCTATAATT GTGGAGACTG CAAGTTTGGC TGGACCGGTC CCAACTGCGA GCGGAAGAAA 780
CCACCAGTGA TTCGGCAGAA CATCCATTCC TTGAGTCCTC AGGAAAGAGA GCAGTTCTTG 840
GGCGCCTTAG ATCTCGCGAA GAAGAGAGTA CACCCCGACT ACGTGATCAC CACACAACAC 900
TGGCTGGGCC TGCTTGGGCC CAATGGAACC CAGCCGCAGT TTGCCAACTG CAGTGTTTAT 960
GATTTTTTTG TGTGGCTCCA TTATTATTCT GTTAGAGATA CATTATTAGG ACCAGGACGC 1020
CCCTACAGGG CCATAGATTT CTCACATCAA GGACCTGCAT TTGTTACCTG GCACCGGTAC 1080
CATTTGTTGT GTCTGGAAAG AGATCTCCAG CGACTCATTG GCAATGAGTC TTTTGCTTTG 1140
CCCTACTGGA ACTTTGCCAC TGGGAGGAAC GAGTGTGATG TGTGTACAGA CCAGCTGTTT 1200
GGGGCAGCGA GACCAGACGA TCCGACTCTG ATTAGTCGGA ACTCAAGATT CTCCAGCTGG 1260
GAAACTGTCT GTGATAGCTT GGATGACTAC AACCACCTGG TCACCTTGTG CAATGGAACC 1320
TATGAAGGTT TGCTGAGAAG AAATCAAATG GGAAGAAACA GCATGAAATT GCCAACCTTA 1380
AAAGACATAC GAGATTGCCT GTCTCTCCAG AAGTTTGACA ATCCTCCCTT CTTCCAGAAC 1440
TCTACCTTCA GTTTCAGGAA TGCTTTGGAA GGGTTTGATA AAGCAGATGG GACTCTGGAT 1S00
TCTCAAGTGA TGAGCCTTCA TAATTTGGTT CATTCCTTCC TGAACGGGAC AAACGCTTTG 1560
CCACATTCAG CCGCCAATGA TCCCATTTTT GTGGTTCTTC ATTCCTTTAC TGATGCCATC 1620
TTTGATGAGT GGATGAAAAG ATTTAATCCT CCTGCAGATG CCTGGCCTCA GGAGCTGGCC 1680
CCTATTGGTC ACAATCGGAT GTACAACATG GTTCCTTTCT TCCCTCCAGT GACTAATGAA 1740
GAACTCTTTT TAACCTCAGA CCAACTTCCC TACAGCTATG CCATCGATCT GCCAGTTTCA 1800
GTTGAAGAAA CTCCAGGTTG GCCCACAACT CTCTTAGTAG TCATGGGAAC ACTGGTGGCT 1860
TTGGTTGGTC TTTTTGTGCT GTTGGCTTTT CTTCAATATA GAAGACTTCG AAAAGGATAT 1920
ACACCCCTAA TGGAGACACA TTTAAGCAGC AAGAGATACA CAGAAGAAGC CTAGGGTGCT 1980
CATGCCTTAC CTAAGAGAAG AGGCTGGCCA AGCCACAGTT CTGACGCTGA CAATAAAGGA 2040
ACTAATCCTC ACTGTTCCTT CTTGAGTTGA AGATCTTTGA CATAGGTTCT TCTATAGTGA 2100
TGATGATCTC ATTCAGAAGA TGCTTAGCTG TAGTTTCCGC TTTGCTTGCT TGTTTAACAA 2160
ACCCAACTAA AGTGCTTGAG GCTACCTCTA CCTTCAAATA AAGATAGACC TGACAATTTG 2220
TGATATCTAA TAATAACCCC CCCCCCAATA TTGATTAAGC CTCCTCCTTT TCTGAAAGCA 2280
TTTAAAAAAA A 2291
Seq ID NO 165 DNA Sequence
Nucleic Acid Accession It XM_059422 3
Coding sequence 207 1400
1 11 21 31 41 51
I I I I I I
TGTGGGGCTG CCCGGGCTGC GCGGCGTCTG CAGGCGCCAC CGCTGCCTCT TTCCGGCTGT 60
GACCCTCCTC GCCGCCGCCG CTTGCCTGCG TCCTCCGACT CCCCGCGCCG CCGAGACCAG 120
GCTCCCGCTC CGGTTGCGGC CGCACCGCCC TCCGCGGCCG CCCCCTGCCG ATCCAGCGAG 180
CGCGGTCGTC CTTGGTGGAA GGAACCATGA ACTGGCATCT CCCCCTCTTC CTCTTCCCCT 240
CTGTGACGCT GCCTTCCATC TGCTCCCACT TCAATCCTCT GTCTCTCGAG GAACTAGGCT 300
CCAACACGCG GATCCAGGTT TTCAATCAGA TTGTGAAGTC GAGGCCTCAT GACAACATCG 360
TGATCTCTCC CCATGGGATT GCGTCGGTCC TGGGGATGCT TCAGCTGGGG GCCCACGGCA 420
GGACCAAGAA GCAGCTCGCC ATGCTGATGA GATACGCCGT AAATGGAGTT GGTAAAATAT 480
TAAAGAAGAT CAACAACCCC ATCGTCTCCA AGAAGAATAA AGACATTGTG ACAGTGGCTA 540
ACGCCGTGTT TGTTAAGAAT GCCTCTGAAA TTGAAGTGCC TTTTGTTACA AGGAACAAAG 600
ATGTGTTCCA GTGTGAGGTC CGGAATGTGA ACTTTGAGGA TCCAGCCTCT GCCTGTGATT 660
CCATCAATGC ATCCGTTAAA AATGAAACCA GGGATATGAT TGACAATCTG CTGTCCCCAG 720
ATCTTATTGA TGGTGTGCTC ACCAGACTGC TCCTCGTCAA CGCAGTGTAT TTCAAGGGTC 780
TGTGGAAATC ACGGTTCCAA CCCGAGAACA CAAAGAAACG CACTTTCGTG GCAGCCGACG 840
GGAAATCCTA TCAAGTGCCA ATGCTGGCCC AGCTCTCCGT GTTCCGGTGT GGGTCGACAA 900
GTGCCCCCAA TGATTTATGG TACAACTTCA TTGAACTGCC CTACCACGGG GAAAGCATCA 960
GCATGCTGAT TGCACTGCCG ACTGAGAGCT CCACTCCGCT GTCTGCCATC ATCCCACACA 1020
TCAGCACCAA GACCATAGAC AGCTCCATGA GCATCATGGT GCCCAAGAGG GTGCAGGTGA 1080
TCCTGCCCAA GTTCACAGCT GTAGCACAAA CAGATTTGAA GGAGCCGCTG AAAGTTCTTG 1140
GCATTACTGA CATGTTTGAT TCATCAAAGG CAAATTTTGC AAAAATAACA AGCTCAGAAA 1200
ACCTCCATGT TTCTCATATC TTGCAAAAAG CAAAAATTGA AGTCAGTGAA GATGGAACCA 1260
AAGCTTCAGC AGCAACAACT GCAATTCTCA TTGCAAGATC ATCGCCTCCC TCCTTTATAG 1320
TAGACAGACC TTTTCTGTTT TTCATCCGAC ATAATCCTAC AGGTGCTGTG TTATTCATGG 1380
GGCAGATAAA CAAACCCTGA AGAGTATACA AAAGAAACCA TGCAAAGCAA CGACTACTTT 1440
GCTACGAAGA AAGACTCCTT TCCTGCATCT TTCATAGTTC TGTTAAATAT TTTTGTACAT 1500
CGCTTCTTTT TCAAAACTAG TTCTTAGGAA CAGACTCGAT GCAAGTGTTT CTGTTCTGGG 1560
AGGTATTGGA GGGAAAAAAC AAGCACCATG GCTGGAACAC TGTACTGAGG AATGAATAGA 1620
AAGGCTTCCA GATGTCTAAA AGATTCTTTA AACTACTGAA CTGTTACCTA GGTTAACAAC 1680
CCTGTTGAGT ATTTGCTGTT TGTCCAGTTC AGGAATTTTT GTTTTGTTTT GTCTATATGT 1740
GCGGCTTTTC AGAAGAAATT TAATCAGTGT GACAGAAAAA AAAATGTTTT ATGGTAGCTT 1800
TTACTTTTTA TGAAAAAAAA ATTATTTGCC TTTTAAATTC TTTTCCCCCA TCCCCCTCCA 1860
AAGTCTTGAT AGCAAGCGTT ATTTTGGTGG TAGAAACGGT GAAATCTCTA GCCTCTTTGT 1920
GTTTTTGTTG TTGTTGTTGT TGTTGTTTTA TATAATGCAT GTATTCACTA AAATAAAATT 1980
TAAAAAACTC CTGTCTTGCT AGACAAGGTT GCTGTTGTGC AGTGTGCCTG TCACTACTGG 2040
TCTGTACTCC TTGGATTTGC ATTTTTGTAT TTTGTACAAA GTAAAAATAA ACTGTTATGA 2100
GTAGT 2105
Seq ID NO 166 DNA Sequence
Nucleic Acid Accession II XM_040512 3
Coding sequence 382 1302
1 11 21 31 41 51
I I I I I I
GGGGCCGCCG GGCAGGAGGA GTTGGAGGAG GACGATGCCT TTATCAGCGT GCAGGTGCCG 60 GCGGCCGCCT TTTTGGGCTC CGGGACCCCC GGGAGTGGGA GCGGCAGTCG GGGACGCCTC 120 AACTCGTTCA CTCAGGGAAT CCTGCCCATC GCCTTCTCCA GGCCGACTTC GCAGAACTAC 180
TGCTCCCTGG AGCAGCCAGG CCAGGGCGGC AGCACCAGCG CCTTCGAGCA GCTGCAGAGG 240
TCCCGACGGC GCCTCATCTC CCAGAGATCT TCCTTGGAGA CCCTGGAAGA TATTGAGGAG 300
AACGCCCCTC TCCCCAGATG TCGAACTCTC TCAGGTTCAC CCAGACCAAA GAATTTTAAG 360
AAGATTCATT TTATCAAGAA CATGCGGCAA CACGATACCA GGAATGGCAG AATAGTCCTT 420
ATCAGTGGCA GAAGATCCTT CTGTAGTATA TTTTCAGTGC TGCCGTATCG CGACAGTACC 480
CAAGTCGGGG ACTTGAAGTT GGACGGAGGA AGACAATCAA CTGGTGCAGT GAGTTTGAAA 540
GAGATCATTG GTCTGGAAGG TGTGGAGCTG GGTGCTGATG GGAAGACTGT TTCCTATACC 600
CAATTTCTGT TACCCACAAA TGCCTTTGGA GCCCGGAGAA ATACCATAGA CTCCACCTCC 660
TCTTTCTCCC AGTTCCGTAA CCTGAGCCAC CGCAGCCTCT CCATAGGCCG GGCAAGCGGC 720
ACCCAGGGGA GCCTCGACAC AGGTAGTGAC CTCCGAGACT TTATGGACTA TGACCCAAAT 780
CTCTTGGATG ACCCCCAGTG GCCTTGTGGC AAACACAAAC GCGTTCTGAT CTTCCCTTCC 840
TACATGACAA CAGTGATTGA CTACGTGAAG CCCTCGGATC TCAAGAAGGA CATGAACGAG 900
ACCTTCAAGG AGAAGTTTCC TCACATTAAG CTGACACTCA GCAAAATTAG GAGTCTGAAA 960
CGAGAGATGC GGAAGCTTGC GCAGGAGGAC TGTGGCCTTG AGGAGCCCAC GGTGGCCATG 1020
GCCTTCGTCT ACTTTGAAAA GCTCGCCCTC AAGGGGAAAC TCAACAAACA GAACCGGAAG 1080
CTGTGTGCTG GGGCATGTGT GCTGTTAGCA GCCAAAATTG GAAGTGACCT CAAAAAACAC 1140
GAAGTCAAGC ATTTAATTGA CAAACTGGAA GAGAAGTTCC GGCTGAACAG GCGAGAACTG 1200
ATTGCCTTTG AATTCCCGGT GTTAGTGGCC TTGGAATTCG CCCTCCACTT GCCCGAGCAC 1260
GAAGTCATGC CCCACTACAG ACGGCTGGTC CAGAGTTCCT AGCACTGGCC CCGAGGACAG 1320
CCAAGGGCCA TTTCTTCTCA GCTTGGTGGA GCAGCACTTA CTTACTACTG GAAATGAAAA 1380
AAAGTAGAAC TCAGAATACC AGACTTTTCT TCCTCTCGAC ATAGTTTGGG GAGAAGCAGT 1440
ACTAGAAACT TTCCAAGGAG TCTTGGGTGT GTAGCCAAGA GGAGCCATGA GCTATGGACT 1S00
CCTCAAGCAC GGGAAGAGGA GGTGTGTGCT GAGAACAGAG AGGCCCTGCC CTCTGTCCAC 1560
TAGCGAGAAT CCCTAGCTGC CCCAGCCCAG TCTTTCTCCC CGGCATTCAC AAACTTTGCA 1620
AGCGTGGTCC AGGGCCTTCT CCAGATCTGT TCCAACTTGG AGTGTGAAGG GCTTGAGCAT 1680
ACGCGGGAAG AGAGTCTGCA GAAGTTGGGG GAAAACTTTT AAAAGATACC CTCATTGTGT 1740
CAAAGAGTGT GCCAATCTAT TTTTGTATCA GCATTGGAAG TGCACTTTCC CCTCCGGCGT 1800
GTGGGTGTGT GAATGTGCAA GTGTCTGAGA GATACTGCAT CAGCCCTAGA CCCCCAGAGC 1860
CAGTCCCGCC CTTTACAGAG CAGCCCTTAG CCTGGGGCCA TGGGTCACCC TGACCTTCAA 1920
CAATTATTTC TAGATGATTT CTCCATAAGA ATTGCTCTCT CGGTACCAGA CAGTTTGACA 1980
TCCTCCACCC TTAGAAAATG ACTGACATTG TTTTGTTACT GCTCCTACCC ACCAAGGGGA 2040
TAAAGAAGGC GAGTTCTGAG TGTTGGATGA GTCAGTCGCG TGGAAGGACG TGGAGCGTGG 2100
CGCTCTGTAA CTTCCTGCCG TCTGCCACCC CGCCACGTGT ATTTAACCCT CGCACTTTCT 2160
CCACTGTGGA GATGGCTCCG GCGGCGCCCC ACAGTGTGTA TTCCTGTCCT CTATGTTAGA 2220
GTGCATCAGA AGCACATTTA CTGTGCTATC TATATCGCTA TATAAAAGTG TTTTATAAAA 2280
ACCCAGAATA GGAGCACGAC GCATGATTGG TGTTTGAGGC GTTTGCCAGC TGGGACAAAC 2340
TGCGTTTGGA GCTGTGGTTA AGCTGACTAA GGAGGCGGTG GCTCTTTCTT AACATTCCCA 2400
CGTGCCCAGG GCTGTTCATG CAAGATTTTA ATGGTGACTT GTCCTGGCTT ACTGGGACAG 2460
TCTGTATGAG GCATGTCACC ACACTGTCGC CTCATAGCTG CAAGAGAGAG GCACCAGCTG 2520
AAGTTCCCCT GACTGAAGAG AGCCTGTGGC CATGTAAAAA GAGAATTAAA CTCTTGTTGC 2580
TTTTTGT 2587
Seq ID NO 167 DNA Sequence
Nucleic Acid Accession II BC008826
Coding sequence 188 2695
1 11 21 31 41 51
I I I I I I
GGCACGAGCC TCCGGCCTCT CCACTAGGAA CCGACAGCCC CCCTCCCCGC GTCCCTCCCT 60
CTCTCTCCAG CCGTTTTGGG GAGGGGCTCT CCACGCTCCG GATAGTTCCC GAGGGTCATC 120
CGCGCCGCAC TCGCCTTTCC GTTTCGCCTT CACCTGGATA TAATTTCCGA GCGAAGCTGC 180
CCCCAGGATG ACCACGCTGG CCGGCGCTGT GCCCAGCATG ATGCGGCCGG GCCCGGGGCA 240
GAACTACCCG CGTAGCGGGT TCCCGCTGGA AGTGTCCACT CCCCTCGGCC AGGGCCGCGT 300
CAACCAGCTC GGCGGCGTTT TTATCAACGG CAGGCCGCTG CCCAACCACA TCCGCCACAA 360
GATCGTGGAG ATGGCCCACC ACGGCATCCG GCCCTGCGTC ATCTCGCGCC AGCTGCGCGT 420
GTCCCACCCC TGCGTCTCCA AGATCCTGTG CACCTACCAG GAGACTGGCT CCATACGTCC 480
TCCTGCCATC GGCGGCAGCA AGCCCAAGGT GACAACGCCT GACGTGGAGA AGAAAATTGA 540
GGAATACAAA AGAGAGAACC CGGGCATGTT CAGCTGGGAA ATCCGAGACA AATTACTCAA 600
GGACGCGGTC TGTGATCGAA ACACCGTGCC GTCAGTGAGT TCCATCAGCC GCATCCTGAG 660
AAGTAAATTC GGGAAAGGTG AAGAGGAGGA GGCCGACTTG GAGAGGAAGG AGGCAGAGGA 720
AAGCGAGAAG AAGGCCAAAC ACAGCATCGA CGGCATCCTG AGCGAGCGAG CCTCAGCACC 780
CCAATCAGAT GAAGGCTCTG ATATTGACTC TGAACCAGAT TTACCACTAA AGAGGAAACA 840
GCGCAGAAGC CGAACCACCT TCACAGCAGA ACAGCTGGAG GAACTGGAGC GTGCTTTTGA 900
GAGAACTCAT TACCCTGACA TTTATACTAG GGAGGAACTG GCCCAGAGGG CGAAGCTCAC 960
CGAGGCCCGA GTACAGGTCT GGTTTAGCAA CCGCCGTGCA AGATGGAGGA AGCAAGCTGG 1020 GGCCAATCAA CTGATGGCTT TCAACCATCT CATTCCCGGG GGGTTCCCTC CCACTGCCAT 1080 GCCGACCTTG CCAACGTACC AGCTGTCGGA GACCTCTTAC CAGCCCACAT CTATTCCACA 1140 AGCTGTGTCA GATCCCAGCA GCACCGTTCA CAGACCTCAA CCGCTTCCTC CAAGCACTGT 1200 ACACCAAAGC ACGATTCCTT CCAACCCAGA CAGCAGCTCT GCCTACTGCC TCCCCAGCAC 1260 CAGGCATGGA TTTTCCAGCT ATACAGACAG CTTTGTGCCT CCGTCGGGGC CCTCCAACCC 1320 CATGAACCCC ACCATTCCCA ATGGCCTCTC ACCTCAGAAT TCAATTCGTC ATAATCTGTC 1380 CCTACACAGC AAGTTCATTC GTGTGCAGAA TGAAGGAACT GGAAAAAGTT CTTGGTGGAT 1440 GCTCAATCCA GAGGGTGGCA AGAGCGGGAA ATCTCCTAGG AGAAGAGCTG CATCCATGGA 1500 CAACAACAGT AAATTTGCTA AGAGCCGAAG CCGAGCTGCC AAGAAGAAAG CATCTCTCCA 1560 GTCTGCCCAG GAGGGTGCTG GGGACAGCCC TGGATCACAG TTTTCCAAAT GGCCTGCAAG 1620 CCCTGGCTCT CACAGCAATG ATGACTTTGA TAACTGGAGT ACATTTCGCC CTCGAACTAG 1680 CTCAAATGCT AGTACTATTA GTGGGAGACT CTCACCCATT ATGACCGAAC AGGATGATCT 1740 TCCAGAAGGG GATGTGCATT CTATGGTGTA CCCGCCATCT GCCGCAAAGA TGGCCTCTAC 1800 TTTACCCAGT CTGTCTGAGA TAAGCAATCC CGAAAACATG GAAAATCTTT TGGATAATCT 1860 CAACCTTCTC TCATCACCAA CATCATTAAC TGTTTCGACC CAGTCCTCAC CTGGCACCAT 1920 GATGCAGCAG ACGCCGTGCT ACTCGTTTGC GCCACCAAAC ACCAGTTTGA ATTCACCCAG 1980 CCCAAACTAC CAAAAATATA CATATGGCCA ATCCAGCATG AGCCCTTTGC CCCAGATGCC 2040 TATACAAACA CTTCAGGACA ATAAGTCGAG TTATGGAGGT ATGAGTCAGT ATAACTGTGC 2100 GCCTGGACTC TTGAAGGAGT TGCTGACTTC TGACTCTCCT CCCCATAATG ACATTATGAC 2160 ACCAGTTGAT CCTGGGGTAG CCCAGCCCAA CAGCCGGGTT CTGGGCCAGA ACGTCATGAT 2220
GGGCCCTAAT TCGGTCATGT CAACCTATGG CAGCCAGGCA TCTCATAACA AAATGATGAA 2280
TCCCAGCTCC CATACCCACC CTGGACATGC TCAGCAGACA TCTGCAGTTA ACGGGCGTCC 2340
CCTGCCCCAC ACGGTAAGCA CCATGCCCCA CACCTCGGGT ATGAACCGCC TGACCCAAGT 2400
GAAGACACCT GTACAAGTGC CTCTGCCCCA CCCCATGCAG ATGAGTGCCC TGGGGGGCTA 2460
CTCCTCCGTG AGCAGCTGCA ATGGCTATGG CAGAATGGGC CTTCTCCACC AGGAGAAGCT 2520
CCCAAGTGAC TTGGATGGCA TGTTCATTGA GCGCTTAGAC TGTGACATGG AATCCATCAT 2580
TCGGAATGAC CTCATGCATG GAGATACATT GGATTTT AC TTTGACAATG TGTTGCCCAA 2640
CCAAAGCTTC CCACACAGTG TCAAGACAAC GACACATAGC TGGGTGTCAG GCTGAGGGTT 2700
AGTGAGCAGG TTACACTTAA AAGTACTTCA GATTGTCTGA CAGCAGGAAC TGAGAGAAGC 2760
AGTCCAAAGA TGTCTTTCAC CAACTCCCTT TTAGTTTTCT TGGTTAAAAA AAAAAAAAAA 2820
AAAAAAA 2827
Seq ID NO: 168 DNA Sequence
Nucleic Acid Accession tt : NM_005761.1
Coding sequence: 250..4956
1 11 21 31 41 51
I I I I I I
GCGAGGAGGA AACGGTGCCG GAGCGCGCAG GGCTTGCTGC CGCCACCGCC GCTGCACAGG 60
CTGCCGGAGC GAGCCTGCCG CGCGCCGCCC TCCCCGCTCT CCTTCCTGGG CGAGCTGCGG 120
GGATGGGGCG GCCGCGGGAG CCCGAGCGCG CGCAGGAACC GCCGCCGCCG CCGCCCGCGT 180
CTCCGTTGCC GCGCGCCTGA GCCGCCGTCG CCGCCGCGCG CCCTGCCCGG GGGCGGCCCC 240
CCCAGCCCCA TGGAGGTCTC CCGGAGGAAG GCGCCGCCGC GCCCCCCGCG CCCCGCAGCG 300
CCACTGCCCC TGCTCGCCTA TCTGCTGGCA CTGGCGGCTC CCGGCCGGGG CGCGGACGAG 360
CCCGTGTGGC GGTCGGAGCA AGCCATCGCA GCCATCGCGG CGAGCCAGGA GGACGGCGTG 420
TTTGTGGCGA GCGGCAGCTG CCTGGACCAG CTGGACTACA GCCTGGAGCA CAGCCTCTCG 480
CGCCTGTACC GGGACCAAGC GGGCAACTGC ACAGAGCCGG TCTCGCTGGC GCCCCCCGCG 540
CGGCCCCGGC CCGCGAGCAG CTTCAGCAAG CTGCTGCTGC CCTACCGCGA GGGGGCGGCC 600
GGCCTCGGGG GGCTGCTGCT CACCGGCTGG ACCTTCGACC GGGGCGCCTG CGAGGTGCGG 660
CCCCTGGGCA ACCTGAGCCG CAACTCCCTG CGCAACGGCA CCGAGGTGGT GTCGTGCCAC 720
CCGCAGGGCT CGACGGCCGG CGTGGTGTAC CGCGCGGGCC GGAACAACCG CTGGTACCTG 780
GCGGTGGCCG CCACCTACGT GCTGCCTGAG CCGGAGACG CGAGCCGCTG CAACCCCGCG 840
GCATCCGACC ACGACACGGC CATCGCGCTC AAGGACACGG AGGGGCGCAG CCTGGCCACG 900
CAGGAGCTGG GGCGCCTCAA GCTGTGCGAG GGCGCGGGCA GCCTGCACTT CGTGGACGCC 960
TTTCTCTGGA ACGGCAGCAT CTACTTCCCC TACTACCCCT ACAACTATAC GAGCGGCGCT 1020
GCCACCGGCT GGCCCAGCAT GGCGCGCATC GCGCAGAGCA CCGAGGTGCT GTTCCAGGGC 1080
CACCCATCCC TCGACTGCGC CCACGGCCAC CCCGACGGCC GCCGCCTGCT CCTCTCCTCC 1140
AGCCTAGTGG AGGCCCTGGA CGTCTGGGCG GGAGTGTTCA GCGCGGCCGC TGGAGAGGGC 1200
CACCAGCGGC GCTCCCCCAC CACCACGGCG CTCTGCCTCT TCAGAATGAG TGAGATCCAG 1260
GCGCGCGCCA AGAGGGTCAG CTGGGACTTC AAGACGGCCG AGAGCCACTG CAAAGAAGGG 1320
GATCAACCTG AAAGAGTCCA ACCAATCGCA TCATCTACCT TGATCCATTC CGACCTGACA 1380
TCCGTTTATG GCACCGTGGT AATGAACAGG ACTGTTTTAT TCTTGGGGAC TGGAGATGGC 1440
CAGTTACTTA AGGTTATTCT TGGTGAGAAT TTGACTTCAA ATTGTCCAGA GGTTATCTAT 1500
GAAATTAAAG AAGAGACACC TGTTTTCTAC AAACTCGTTC CTGATCCTGT GAAGAATATC 1560
TACATTTATC TAACAGCTGG GAAAGAGGTG AGGAGAATTC GTGTTGCAAA CTGCAATAAA 1620
CATAAATCCT GTTCGGAGTG TTTAACAGCC ACAGACCCTC ACTGCGGTTG GTGCCATTCG 1680
CTACAAAGGT GCACTTTTCA AGGAGATTGT GTACATTCAG AGAACTTAGA AAACTGGCTG 1740
GATATTTCGT CTG AGCAAA AAAGTGCCCT AAAATTCAGA TAATTCGAAG CAGTAAAGAA 1800
AAGACTACAG TGACTATGGT GGGAAGCTTC TCTCCAAGAC ACTCAAAGTG CATCCTGAAG 1860
AATGTGGACT CTAGCAGGGA GCTCTGCCAG AATAAAAGTC AGCCCAACCG GACCTGCACC 1920
TGTAGCATCC CAACCAGAGC AACCTACAAA GATGTTTCAG TTGTCAACGT GATGTTCTCC 1980
TTCGGTTCTT GGAATTTATC AGACAGATTC AACTTTACCA ACTGCTCATC ATTAAAAGAA 2040
TGCCCAGCAT GCGTAGAAAC TGGCTGCGCG TGGTGTAAAA GTGCAAGAAG GTGTATCCAC 2100
CCCTTCACAG CTTGCGACCC TTCTGATTAT GAGAGAAACC AGGAACAGTG TCCAGTGGCT 2160
GTCGAGAAGA CATCAGGAGG AGGAAGACCC AAGGAGAACA AGGGGAACAG AACCAACCAG 2220
GCTTTACAGC TCTTCTACAT TAAGTCCATT GAGCCACAGA AAGTATCGAC ATTACCGAAA 2280
AGCAACGTGA TAGTAACGGG AGCAAACTTT ACCCGGGCAT CGAACATCAC AATGATCCTG 2340
AAAGGAACCA GTACCTGTGA TAAGGATGTG ATACAGGTTA GCCATGTGCT AAATGACACC 2 00
CACATGAAAT TCTCTCTTCC ATCAAGCCGG AAAGAAATGA AGGATGTGTG TATCCAGTTT 2460
GATGGTGGGA ACTGCTCTTC TGTGGGATCC TTATCCTACA TTGCTCTCCC ACATTGTTCC 2520
CTTATATTTC CTGCTACCAC CTGGATCAGT GGTGGTCAAA ATATAACCAT GATGGGCAGA 2580
AATTTTGATG TAATTGACAA CTTAATCATT TCACATGAAT TAAAAGGAAA CATAAATGTC 2640
TCTGAATATT GTGTGGCGAC TTACTGCGGG TTTTTAGCCC CCAGTTTAAA GAGTTCAAAA 2700
GTGCGCACGA ATGTCACTGT GAAGCTGAGA GTACAAGACA CCTACTTGGA TTGTGGAACC 2760
CTGCAGTATC GGGAGGACCC CAGATTCACG GGGTATCGGG TGGAATCCGA GGTGGACACA 2820
GAACTGGAAG TGAAAATTCA AAAAGAAAAT GACAACTTCA ATATTTCCAA AAAAGACATT 2880
GAAATTACTC TCTTCCATGC GGAAAATGGG CAATTAAATT GCAGTTTTGA AAATATTACT 2940
AGAAATCAAG ATCTTACCAC CATCCTTTGC AAAATTAAAG GCATCAAGAC TGCAAGCACC 3000
ATTGCCAACT CTTCTAAGAA AGTTCGGGTC AAGCTGGGAA ACCTGGAGCT CTACGTCGAG 3060
CAGGAGTCAG TTCCTTCCAC ATGGTATTTT CTGATTGTGC TCCCTGTCTT GCTAGTGATT 3120
GTCATTTTTG CGGCCGTGGG GGTGACCAGG CACAAATCGA AGGAGCTGAG TCGCAAACAG 3180
AGTCAACAAC TAGAATTGCT GGAAAGCGAG CTCCGGAAAG AGATACGTGA CGGCTTTGCT 3240
GAGCTGCAGA TGGATAAATT GGATGTGGTT GATAGTTTTG GAACTGTTCC CTTCCTTGAC 3300
TACAAACATT TTGCTCTGAG AACTTTCTTC CCTGAGTCAG GTGGCTTCAC CCACATCTTC 3360
ACTGAAGATA TGCATAACAG AGACGCCAAC GACAAGAATG AAAGTCTCAC AGCTTTGGAT 3420
GCCCTAATCT GTAATAAAAG CTTTCTTGTT ACTGTCATCC ACACCCTTGA AAAGCAGAAG 3480
AACTTTTCTG TGAAGGACAG GTGTCTGTTT GCCTCCTTCC TAACCATTGC ACTGCAAACC 3540
AAGCTGGTCT ACCTGACCAG CATCCTAGAG GTGCTGACCA GGGACTTGAT GGAACAGTGT 3600
AGTAACATGC AGCCGAAACT CATGCTGAGA CGCACGGAGT CCGTCGTCGA AAAACTCCTC 3660
ACAAACTGGA TGTCCGTCTG CCTTTCTGGA TTTCTCCGGG AGACTGTCGG AGAGCCCTTC 3720
TATTTGCTGG TGACGACTCT GAACCAGAAA ATTAACAACC GTCCCGTGGA TGTAATCACT 3780
TGCAAAGCCC TGTACACACT TAATGAAGAC TGGCTGTTGT GGCAGGTTCC GGAATTCAGT 3840
ACTGTGGCAT TAAACGTCGT CTTTGAAAAA ATCCCGGAAA ACGAGAGTGC AGATGTCTGT 3900
CGGAATATTT CAGTCAATGT TCTCGACTGT GACACCATTG GCCAAGCCAA AGAAAAGATT 3960 TTCCAAGCAT TCTTAAGCAA AAATGGCTCT CCTTATCCAC TTCAGCTTAA TGAAATTGGT 4020
CTTGAGCTTC AAATGGGCAC ACGACAGAAA GAACTTCTGG ACATCGACAG TTCCTCCGTG 4080
ATTCTTGAAG ATGGAATCAC CAAGCTAAAC ACCATTGGCC ACTATGAGAT ATCAAATGGA 4140
TCCACTATAA AAGTCTTTAA GAAGATAGCA AATTTTACTT CAGATGTGGA GTACTCGGAT 4200
GACCACTGCC ATTTGATTTT ACCAGATTCG GAAGCATTCC AAGATGTGCA AGGAAAGAGA 4260
CATCGAGGGA AGCACAAGTT CAAAGTAAAA GAAATGTATC TGACAAAGCT GCTGTCGACC 4320
AAGGTGGCAA TTCATTCTGT GCTTGAAAAA CTTTTTAGAA GCATTTGGAG TTTACCCAAC 4380
AGCAGAGCTC CATTTGCTAT AAAATACTTT TTTGACTTTT TGGACGCCCA GGCTGAAAAC 4440
AAAAAAATCA CAGATCCTGA CGTCGTACAT ATTTGGAAAA CAAACAGCCT TCCTCTTCGC 4500
TTCTGGGTAA ACATCCTGAA GAACCCTCAG TTTGTCTTTG ACATTAAGAA GACACCACAT 4560
ATAGACGGCT GTTTGTCAGT GATTGCCCAG GCATTCATGG ATGCATTTTC TCTCACAGAG 4620
CAGCAACTAG GGAAGGAAGC ACCAACTAAT AAGCTTCTCT ATGCCAAGGA TATCCCAACC 4680
TACAAAGAAG AAGTAAAATC TTATTACAAA GCAATCAGGG ATTTGCCTCC ATTGTCATCC 4740
TCAGAAATGG AAGAATTTTT AACTCAGGAA TCTAAGAAAC ATGAAAATGA ATTTAATGAA 4800
GAAGTGGCCT TGACAGAAAT TTACAAATAC ATCGTAAAAT ATTTTGATGA GATTCTAAAT 4860
AAACTAGAAA GAGAACGAGG GCTCCAAGAA GCTCAGAAAC AACTCTTGCA TGTAAAAGTC 4920
TTATTTGATG AAAAGAAGAA ATGCAAGTGG ATGTAAGCAC TCTGGGGCCT GGCTTAATCT 4980
GGCAAAGTTC TTCAGACGAC TTGGGAGCAA AATGGCTGCT TGAGCTACTC TGTGTCGTTA 5040
ATTTGTTGTT TGCACATAGG TTCCACTTTG GGCACTGTCT TTTTAAGAGA CCAAGGCACA 5100
TGCACAGCTT TTAGAAAGCA A 5121
Seq ID NO 169 DNA Sequence
Nucleic Acid Accession tt XM_063670 1
Coding sequence 1 708
1 11 21 31 41 51
I I I I I I
ATGCAGAGAA TCCTTGAGGA ACCAGCTGAT GATTGCACAT GGTCAACTCG GATTCTTCTT 60
ACCCTGAGTG AATTTATAAT GTCGCTGCAG CGTACTGTTT ATCCCCACAG TGAGAAGTGG 120
CGTGCTCTCT CAGTCCCTTC ATCTTCCTAT TTTCAGGAGC TGGTGGGCAC CAGCCAGGAA 180
CTGGCTCTCA CCTTCTGGCA TTTACTGTCT ATGTTTGGAT TCTTCATCGT GTCCTATGGC 240
TTTCTCACAG CATTTGGCAG GACTCTTTTC CACTTCCATC TGCTACAACC CAACCTTACA 300
CCTTCACGCT TTGACAAGTA CACTGGTCTC TTCATCTATG AAATAGAGGG AGATGGGTTA 360
GATCCATGTT TTCAAAGCAT GGTCCAAGGA ATCCTAGAGG TTTTGTGGAT GTCCAAAGTG 420
GAGAGTGCAT ACCACACTAA TGATGGTGAT ACTGCTGCAG AGGGGGTGGA AAATGGTACC 480
AGTCAAACCC GAGGCGGAGG AGGAGCAGCC CGCAGTCGCT GCCGCGAGAT GGAGGAGCCC 540
ACGCCCGAGC CCGTCTATGT CGACGTAGAC AAAGGGCTGA CCTTCCCCTG CTTCGTCTTC 600
CTCTGCCTCT TCCTTGTCGT GATGATCATC CGCTGTGCCA AGGTCATCAT GGACCCTTAC 660
AGCGCCATCC CCACATCCAC CTGGGAGGAG CAGCACCTGG ACGACTGA 708
Seq ID NO 170 DNA Sequence
Nucleic Acid Access ion # FGENESH predicted
Coding sequence 1 - 936
1 11 21 31 41 51
I I I I I I
ATGGAGCCAA GCCACAGCCA ACCCACAATG GACATGAAGC ACATGCAAGA GCGTCCAGCT 60
GCCTCGCCTT TAAAATGCCA GGACGCCCGC GGCTCCGCTC AGAGCCCCCT CTCGCCTGCT 120
GGCCCGGGCT CGCCCGCGCC GCTGGGGGCT CTGACTCCTG CCGAGCCGGG CCTGGGCAGC 180
GCCCCCCGCG CCCCGCGAGC CCGCGCCCCC GTCACCGGGA AACGCCGTAG CCGGCGATCC 240
GCGGTCGCCC TGGGCTCCCC GCCGGCCCAG CCAGGACCCC GGGAGCGCAC CCGACGGGCC 300
TCGCCAGCCC TAGAAAATAA CTCTGACCTC TTGTCCAAGG CATCTGCTAT AGCTACTGGG 360
ACACCACCCT GTGAAGACTC TACCATTGCA AGGTTCTACC TGCCCCCACC TCTCACCACT 420
CACCCCGAGC TGGTGGGCAC CAGCCAGGAA CTGGCTCTCA CCTTCTGGCA TTTACTGTCT 480
ATGTTTGGAT TCTTCATCGT GTCCTATGGC TTTCTCACAG CATTTGGCAG GACTCTTTTC 540
CACTTCCATC TGCTACAACC CAACCTTACA CCTTCACGCT TTGACAAGTA CACTGGCCAG 600
CTCCTCGAGC TCCCAGTTCA CTCAAAGTAT GTACTGACCA TCCACTGGAG CCAGGGACTG 660
TGCATTTCCT CGTCACATCC CTGTGAAGCA GGGGTGGAAA ATGGTACCAG TCAAACCCGA 720
GGCGGAGGAG GAGCAGCCCG CAGTCGCTGC CGCGAGATGG AGGAGCCCAC GCCCGAGCCC 780
GTCTATGTCG ACGTAGACAA AGGGCTGACC TTGGCCTGCT TCGTCTTCCT CTGCCTCTTC 840
CTTGTCGTGA TGATCATCCG CTGTGCCAAG GTCATCATGG ACCCTTACAG CGCCATCCCC 900
ACATCCACCT GGGAGGAGCA GCACCTCCAC GACTGA 936
Seq ID NO 171 DNA Sequence
Nucleic Acid Access ion tt FGENESH predicted
Coding sequence 1 - 2094
1 11 21 31 41 51
I I I I I I
ATGGGCAAGG ATTTCATGTC TAAAACACCA AAAGCAATGG CAACACAAGC CAAAATTGAC 60
AAATGGGATC TAATTAAACT AAAGAGCTTC TGCACAGCAA AAGAAACTAC CATCAGAGTG 120
AACAGACAAC CTACAGAATG GGAGAAAATT TTTGCAATCT ACTCATCTGA CGAAGGGCTA 180
ATATCCAGAA TCTACAATGA ACCCAAACAA ATTTACAAGA AAAAAACAAA CAACCCTATC 240
AACAAGTGGG CGAAGGATAT GAACAGACAC TTCTCAAAAG AAGACATTTA TGCAGCCAAC 300
AGACACATGA AAAAATGCTC ATCATCACTG GCCATCAGAG AAATGCAAAT CAAAACCACA 360
ACGAGATGCC ATCTCACACC AGTTAGAATG GCGATCATTA AAAAGTCAGG AAACAACAGA 420
ACTGCAGAAG AACAGCCAAA ACTGAGAAAG GAAGCAGTTG GATCTATTGA GATATTCCGC 480
TTTGCTGATG GACTGGACAT CACACTCATG ATCCTGGGTA TACTGGCATC ACTCCTCAAT 540
GGAGCCTGCC TTCCTTTAAT GCCACTGGTT TTAGGAGAAA TGAGTGATAA CCTTATTAGT 600
GGATGTCTAG TCCAAACTAA CACAACAAAT TATCAGAACT GTACTCAGTC TCAAGAGAAG 660
CTGAATGAAG ATATGACTCT GTTGACCCTG TATTATGTTG GAATAGGTGT TGCTGCCTTG 720
ATTTTTGGTT ACATACAGAT TTCCTTGTGG ATTATAACTG CAGCACGACA GACCAAGAGG 780
ATTCGAAAAC AGTTTTTTCA TTCAGTTTTG GCACAGGACA TCGGCTGGTT TGATAGCTGT 840
GACATCGCTG AACTTAACAC TCGCATGACA GATGACATTG ACAAAATCAG TGATGGTATT 900
GGAGATAAGA TTGCTCTGTT GTTTCAAAAC ATGTCTACTT TTTCGATTGG CCTCCCAGTT 960
GGTTTGGTGA AGGGCTGGAA ACTCACCCTA GTGACTCTAT CCACGTCTCC TCTTATAATG 1020
GCTTCAGCGG CAGCATGTTC TAGGATGGTC ATCTCATTGA CCAGTAAGGA ATTAAGTGCC 1080 TATTCCAAAG CTGGGGCTGT GGCAGAAGAA GTCTTGTCAT CAATCCGAAC AGTCATAGCC 1140
TTTAGGGCCC AGGAGAAAGA ACTTCAAAGG TATACACAGA ATCTCAAAGA TGCAAAGGAT 1200
TTTGGCATAA AAAGGACTAT AGCTTCAAAA GTGTCTCTTG GTGCTGTGTA CTTCTTTATG 1260
AATGGAACCT ATGGACTTGC TTTTTGGTAT GGAACCTCCT TGATTCTTAA TGGAGAACCT 1320 GGATATACCA TCGGGACTGT TCTTGCTGTT TTCTTTAGTG TAATCCATAG CAGTTATTGC 1380
ATTGCAGCAG CAGTCCCTCA CTTTGAAACC TTCGCAATAG CCCGAGGAGC TGCCTTTCAT 1440
ATTTTCCAGG TTATTGATAA GAAACCCAGT ATAGATAACT TTTCCACAGC TGGATATAAA 1500
CCTGAATCCA TAGAAGGAAC TGTGGAATTT AAAAATGTTT CTTTCAATTA TCCATCAAGA 1560
CCATCTATCA AGATTCTGAA AGGTCTGAAT CTCAGAATTA AGTCTGGAGA GACAGTCGCC 1620 TTGGTCGGTC TCAATGGCAG TGGGAAGAGT ACGGTAGTCC AGCTTCTGCA GAGGTTATAT 1680
GATCCGGATG ATGGCTTTAT CATGGTGGAT GAGAATGACA TCAGAGCTTT AAATGTGCGG 1740
CATTATCGAG ACCATATTGG AGTGGTTAGT CAAGAGCCTG TTTTGTTCGG GACCACCATC 1800
AGTAACAATA TCAAGTATGG ACGAGATGAT GTGACTGATG AAGAGATGGA GAGAGCAGCA 1860
AGGGAAGCAA ATGCGTATGA TTTTATCATG GAGTTTCCTA ATAAATTTAA TACATTGGTA 1920 GGGGAAAAAG GAGCTCAAAT GAGTGGAGGG CAGAAACAGA GGATCGCAAT TGCTCGTGCC 1980
TTAGTTCGAA ACCCCAAGAT TCTGATTTTA GATGAGGCTA CGTCTGCCCT GGATTCAGAA 2040
AGCAAGTCAG CTGTTCAAGC TGCACTGGAG AAGGATACCC CCAGGTATTC ATTTTGA 2097
Seq ID NO: 172 DNA Sequence Nucleic Acid Accession #: XM_166496.1 Coding sequence: 378..773 1 11 21 31 41 51
I I I I I I
CC AATTCCT CTAATATCTC TCTGTTTTCT TTAGTGTAAT CCATAGCAGT TATTGCATTG 60 GAGCAGCAGT CCCTCACTTT GAAACCTTCG CAATAGCCCG AGGAGCTGCC TTTCATATTT 120
TCCAGGTTAT TGATAAGAAA CCCAGTATAG ATAACTTTTC CACAGCTGGA TATAAACCTG 180
AATCCATAGA AGGAACTGTG GAATTTAAAA ATGTTTCTTT CAATTATCCA TCAAGACCAT 240
CTATCAAGAT TCTGAAAGGT CTGAATCTCA GAATTAAGTC TGGAGAGACA GTCGCCTTGG 300
TCGGTCTCAA TGGCAGTGGG AAGAGTACGG TAGTCCAGCT TCTGCAGAGG TTATATGATC 360 CCCATGATGG CTTTATCATG GTGGATGAGA ATGACATCAG AGCTTTAAAT GTGCGGCATT 420
ATCGAGACCA TATTGGAGTG GTTAGTCAAG AGCCTGTTTT GTTCGGGACC ACCATCAGTA 480
ACAATATCAA GTATGGACGA GATGATGTGA CTGATGAAGA GATGGAGAGA GCAGCAAGGG 540
AAGCAAATGC GTATGATTTT ATCATGGAGT TTCCTAATAA ATTTAATACA TTGCTAGGGG 600
AAAAAGGAGC TCAAATGAGT GGAGGGCAGA AACAGAGGAT CGCAATTGCT CGTGCCTTAG 660 TTCGAAACCC CAAGATTCTG ATTTTAGATG AGGCTACGTC TGCCCTGGAT TCAGAAAGCA 720
AGTCAGCTGT TCAAGCTGCA CTGGAGAAGG ATACCCCCAG GTATTCATTT TGACCTAATT 780
TCACCTCAAG TGGAGAATCG CTGACCTTGA ACCAGCGCCC TTCGACAGCT CTGCCCCCTC 840
AAACCTCACC CTGACCTCCT GCTGCCTATG AGCTACTG 878 Seq ID NO : 173 DNA Sequence
Nucleic Acid Accession tt : XM_166305 .2
Coding sequence - 157 . .1104
1 11 21 31 41 51
I I I I I I
GAGAAGCCCT CTTCCCTTTA AAAAAAAAAA AAAAAAGGCT GCTTCTCGCA GAGTGGAAAG 60
CCCCCCTCCC CATCCCACCA AAACCATTTG ACAAGCAGGA CAACGAAGAG GCAGAAGGAT 120
CTGGGCCTGT GCGCGACGCC CCGGGGGACG AGGCTCATGG AGAAGTTTCG GGCCCTGCTG 180
GACCTGCACG TCAAGCACCA CAGCGCCTTG GGCTACGGCC TGGTGACCCT GCTGACGGCG 240
GGCGGGGAGC GCATCTTCTC CGCCGTGGCA TTCCAGTGCC CGTGCAGCGC CGCCTGGAAC 300
CTGCCCTACG GCCTGGTCTT CTTGCTGGTG CCGGCGCTCG CGCTCTTCCT CCTGGGCTAC 360
GTGCTGAGCG CACGCACGTG GCGCCTGCTC ACCGGATGCT GCTCCAGCGC CCGCGCGAGT 420
TGCGGATCGG CGCTGCGCGG CTCCCTGGTG TGCACGCAAA TCAGCGCGGC CGCCGCGCTC 480
GCGCCCCTCA CCTGGGTGGC CGTGGCGCTG CTCGGGGGCG CCTTTTACGA GTGCGCGGCC 540
ACCGGGAGCG CGGCCTTCGC GCAGCGCCTG TGCCTCGGCC GCAACCGCAG CTGCGCCGCG 600
GAGCTGCCGC TGGTGCCGTG CAACCAGGCC AAGGCGTCGG ACGTGCAGGA CCTCCTGAAG 660
GATCTGAAGG CTCAGTCGCA GGTGTTGGGC TGGATCTTGA TAGCAGTTGT TATCATCATT 720
CTTCTGATTT TTACATCTGT CACCCGATGC CTATCTCCAG TTAGTTTTCT GCAGCTGAAA 780
TTCTGGAAAA TCTATTTGGA ACAGGAGCAG CAGATCCTTA AAAGTAAAGC CACAGAGCAT 840
GCAACTGAAT TGGCAAAAGA GAATATTAAA TGTTTCTTTG AGGGCTCGCA TCCAAAAGAA 900
TATAACACTC CAAGCATGAA AGAGTGGCAG CAAATTTCAT CACTGTATAC TTTCAATCCG 960
AAGGGCCAGT ACTACAGCAT GTTGCACAAA TATGTCAACA GAAAAGAGAA GACTCACAGT 1020
ATCAGGTCTA CTGAAGGAGA TACGGTGATT CCTGTTCTTG GCTTTGTAGA TTCATCTGGT 1080
ATAAACAGCA CTCCTGAGTT ATGACCTTTT GAATGAGTAG AAAAAAAAAT TGTTTTGAAT 1140
TATTGCTTTA TTAAAAAATA AACATTGGTA TTTTT 1175
Seq ID NO : 174 DNA Sequence Nucleic Acid Accession tt ■ NM_032211 . 5 Coding sequence : 152 . .2422
1 11 21 31 41 51 I I I I I I
GGCTGGGGGG CCGCGGGCGG GAGGCGGATA AAAAGGCCCC AGGGCGCCCG GGGAGGGAGC 60
CCGTTAGCGC TGCTCCGCCG CGCCGCCCGC CCAGCCCCGG ACTGTCCGCG CTCCATCTCC 120
TATCTTGGCC TCAGCTGTCC TTGAAGTCAC CATGGCGAGG TCCCCACCAG CCACCCTCTT 180
TCTGTTCCTG CTGCTGCTAG GCCAGCCCCC TCCCAGCAGG CCACAGTCAC TGGGCACCAC 240
TAAGCTCCGG CTGGTGGGCC CAGAGAGCAA GCCAGAGGAG GGCCGCCTGG AGGTGCTGCA 300
CCAGGGCCAG TGGGGCACCG TGTGTGATGA CAACTTTGCT ATCCAGGAGG CCACAGTGGC 360
TTGCCGCCAG CTGGGCTTCG AAGCTGCCTT GACCTGGGCC CACAGTGCCA AGTACGGCCA 420
AGGGGAGGGA CCCATCTGGC TGGACAATGT GCAGTGTGTG GGCACAGAGA GCTCCTTGGA 480
CCAGTGCGGG TCTAATGGCT GGGGAGTCAG TGACTGCAGT CACTCAGAAG ACGTAGGGGT 540
GATATGCCAC CCCCGGCGCC ATCGTGGCTA CCTTTCTGAA ACTGTCTCCA ATGCCCTTGG 600
GCCCCAGGGC CGGCGGCTGG AGGAGGTGCG GCTCAAGCCC ATCCTTGCCA GTGCCAAGCA 660
GCATAGCCCA GTGACCGAGG GAGCCGTGGA GGTGAAGTAT GAGGGCCACT GGCGGCACCT 720
GTGTGACCAG GGCTGGACCA TGAACAACAG CAGGGTGGTG TGCGGGATGC TGGGCTTCCC 780
CAGCGAGGTG CCTGTCGACA GCCACTACTA CAGGAAAGTC TGGGATCTGA AGATGAGGGA 840 CCCTAAGTCT AGGCTGAAGA GCCTGACGAA TAAGAACTCC TTCTGGATCC ACCAGGTCAC 900
CTGCCTGGGG ACAGAGCCCC ACATGGCCAA CTGCCAGGTG CAGGTGGCTC CAGCCCGGGG 960
CAAGCTGCGG CCAGCCTGCC CAGGTGGCAT GCATGCTGTG GTCAGCTGTG TGGCAGGGCC 1020
TCACTTCCGC CCACCGAAGA CAAAGCCACA ACGCAAAGGG TCCTG GCAG AGGAGCCGAG 1080 GGTGCGCCTG CGCTCCGGGG CCCAGGTGGC CGAGGGCCGG GTGGAAGTGC TCATGAACCG 1140
CCAGTGGGGC ACGGTCTGTG ACCACAGGTG GAACCTCATC TCTGCCAGTG TCGTGTGTCG 1200
TCAGCTGGGC TTTGGCTCTG CTCGGGAGGC CCTCTTTGGG GCCCGGCTGG GCCAAGGGCT 1260
AGGGCCCATC CACCTGAGTG AGGTGCGCTG CAGGGGATAT GAGCGGACCC TCAGCGACTG 1320
CCCTGCCCTG GAAGGGTCCC AGAATGGTTG CCAACATGAG AATGCTGCTG CTGTCAGGTG 1380 CAATGTCCCT AACATGGGCT TTCAGAATCA GGTGCGCTTG GCTCCTCCGC GTATCCCTGA 1440
GGAGGGGCTA TTGGAGGTGC AGGTGGAGGT GAACGGGGTC CCACGCTGGG GGAGCGTGTG 1500
CAGTGAAAAC TGGGGGCTCA CCGAAGCCAT GGTGGCCTGC CGACAGCTCG GCCTGCGTTT 1560
TGCCATCCAT GCCTACAAGG AAACCTGGTT CTGGTCGGGG ACGCCAAGGG CCCACCAGGT 1620
GGTGATGAGT GGGGTGCGCT GCTCAGGCAC AGAGCTGGCC CTGCAGCAGT GCCAGAGGCA 1680 CGGGCCGGTG CACTGCTCCC ACGGTGGCGG GCGCTTCCTG GCTGGAGTCT CCTGCATGGA 1740
CAGTGCACCA GACCTGGTGA TGAACGCCCA GCTAGTGCAG GAGACGGCCT ACTTGGAGGA 1800
CCGCCCGCTC AGCCAGCTGT ATTGTGCCCA CGAGGAGAAC TGCCTCTCCA AGTCTGCGGA 1860
TCACATGGAC TGGCCCTACG GATACCGCCG CCTATTGCGC TTCTCCACAC AGATCTACAA 1920
TCTGGGCCGG ACTGACTTTC GTCCAAAGAC TGGACGCGAT AGCTGGGTTT GGCACCAGTG 1980 CCACAGGCAT TACCACAGCA TTGAGGTCTT CACCCACTAC GACCTCCTCA CTCTCAATGG 2040
CTCCAAGGTG GCTGAGGGGC ACAAGGCCAG CTTCTGTCTG GAGGACACAA ACTGCCCCAC 2100
AGGACTGCAG CGGCGCTACG CATGTGCCAA CTTTGGAGAA CACCGAGTGA CTGTAGGCTG 2160
CTGGGACACC TACCGGCATG ACATTGATTG CCAGTGGGTG GATATCACAG ATGTGGGCCC 2220
CGGGAATTAT ATCTTCCAGG TGATTGTGAA CCCCCACTAT GAAGTGGCAG AGTCAGATTT 2280 CTCCAACAAT ATGCTGCAGT GCCGCTGCAA GTATGATGGG CACCGGGTCT GGCTGCACAA 23 0
CTGCCACACA GGGAATTCAT ACCCAGCCAA TGCAGAACTC TCCCTGGAGC AGGAACAGCG 2400
TCTCAGGAAC AACCTCATCT GAAGCTGTCA CTGCACACTC CTAGCTGCTG CCGATACACC 2460
AGATACCTCA GCTTATTGGA GCCATGCCCT TCACAGAGTC CCAACTCAGA GGAAAAGGGC 2520
CAGTGCCAAG GGGCACCAAG AACCTGCTCA GGAAGCCTTT TGATGGCAAG ATCACCAATC 2580 CAGATGGTAT TGCTCCCTCA GGATGGCTCT GGGCCTGCCC CTAAGGGCCT GTGGCCTATG 2640
GAATATGTCC TCCAGGCTTT GCTCAGCTGA GCTCCTCTTC TGTAAGGAAA CCCAGTCATC 2700
CCTGAATCTT GCCACAGAGA TCCGGGATTC AGGAGCTCTC AGTTTCTTAG GGATGGACTA 2760
TGGCCCAGTC CCCCATCTAA GTGGTGCTTT GCAAATGTCT TGGAGGAGTA TAGGACAGAG 2820
GACCAAAATA CACAGCAGGT AGTGTTAGCT CTCTGCTAGG AGCTCAAAGC AACACAACTT 2880 GTATCAAAAT CACAACTGGC AGAGAAGCTG GTGGATCCAA TCCTTTCTTC ATCTGTTGTT 2940
ATTTAGAACT CACCTCTCAC ACTCTGTTCT TTAGTGTCCT TACCTTTATC TTACCACACA 3000
CATGGGTGTT TC ATTATCC TTGGAAGCAC AGACCTCGGG CATCCCCTTA TTGCCTGATG 3060
GGCCAACACC AACAGTTACG GAGTGCTTGA GAAGGGGCAA GTTTCACAGA AATGGCCAGA 3120
TAGGGCCTTC CTACAGAGCA GCAAGAGTAG GCCAAGCAGA AAGACTGCTG AGGTAACACG 3180 GACCCCAGCC CCTGTCAGGG CCTCTGCCAA GGAAATAATA TGGACCATTT ACCTGGCAGG 3240
CAGTCTGCTC TCTCTCAGGA TCACCACGCA TCTCAGGATT GGTCTAAACT TCAAGTCTCA 3300
ACCAAGTGTC TGAAGTGAAC TTTGCATTGA ATAAATTTTT GCCATGGAAA GAACATCAAA 3360
CAAGCCACTC ATCTCTACAG AGATAAGAAA ACAAGTTTGG CAGAGCAAGA GACAGAAGAC 3420
CGTGGAGAAA TCAGAAGGGG GAACAGTCAG TTTAGTTAAG GATGGAACCT GGGAAAGGCC 3480 ACCATTCCTG CTTGATGGGG CTCTGATTTG CTCTTGCTCA AGTGGAATAA AACCCCATGG 3540
TCTTCTTGAC ATGATTCTTG ATCTTTTCTC CACTGAGACA CACTTAAGTG ATGATCCTTA 3600
CAGGACTGAC ACCCTAATGC CAATAAAAGT TGCTCATTAT GGACTGCTAC AAAAAAAAAA 3660
AAAAA 3665
Seq ID NO: 175 DNA Sequence
Nucleic Acid Accession ft: NM_001798.2
Coding sequence: 234..1130
1 11 21 31 41 51
I I I I I I
GGAAGCAGGG CGGGGCCTCT GGTGGCGGTC GGGAACTCCC TGGGAGGCGG CAACATTGTT 60
TCAAGTTGGC CAAATTGACA AGAGCGAGAG GTATACTGCG TTCCATCCCG ACCCGGGGCC 120
ACGGTACTGG GCCCTGTTTC CCCCTCCTCG GCCCCCGAGA GCCAGGGTCC GCCTTCTGCA 180
GGGTTCCCAG GCCCCCGCTC CAGGGCCGGG CTGACCCGAC TCGCTGGCGC TTCATGGAGA 2 0
ACTTCCAAAA GGTGGAAAAG ATCGGAGAGG GCACGTACGG AGTTGTGTAC AAAGCCAGAA 300
ACAAGTTGAC GGGAGAGGTG GTGGCGCTTA AGAAAATCCG CCTGGACACT GAGACTGAGG 360
GTGTGCCCAG TACTGCCATC CGAGAGATCT CTCTGCTTAA GGAGCTTAAC CATCCTAATA 420
TTGTCAAGCT GCTGGATGTC ATTCACACAG AAAATAAACT CTACCTGGTT TTTGAATTTC 480
TGCACCAAGA TCTCAAGAAA TTCATGGATG CCTCTGCTCT CACTGGCATT CCTCTTCCCC 540
TCATCAAGAG CTATCTGTTC CAGCTGCTCC AGGGCCTAGC TTTCTGCCAT TCTCATCGGG 600
TCCTCCACCG AGACCTTAAA CCTCAGAATC TGCTTATTAA CACAGAGGGG GCCATCAAGC 660
TAGCAGACTT TGGACTAGCC AGAGCTTTTG GAGTCCCTGT TCGTACTTAC ACCCATGAGG 720
TGGTGACCCT GTGGTACCGA GCTCCTGAAA TCCTCCTGGG CTGCAAATAT TATTCCACAG 780
CTGTGGACAT CTGGAGCCTG GGCTGCATCT TTGCTGAGAT GGTGACTCGC CGGGCCCTAT 840
TCCCTGCAGA TTCTGAGATT GACCAGCTCT TCCGGATCTT TCGGACTCTG GGGACCCCAG 900
ATGAGGTGGT GTGGCCAGGA GTTACTTCTA TGCCTGATTA CAAGCCAAGT TTCCCCAAGT 960
GGGCCCGGCA AGATTTTAGT AAAGTTGTAC CTCCCCTGGA TGAAGATGGA CGGAGCTTGT 1020
TATCGCAAAT GCTGCACTAC GACCCTAACA AGCGGATTTC GGCCAAGGCA GCCCTGGCTC 1080
ACCCTTTCTT CCAGGATGTG ACCAAGCCAG TACCCCATCT TCGACTCTGA TAGCCTTCTT 1140
GAAGCCCCCA GCCCTAATCT CACCCTCTCC TCCAGTGTGG GCTTGACCAG GCTTGGCCTT 1200
GGGCTATTTG GACTCAGGTG GGCCCTCTGA ACTTGCCTTA AACACTCACC TTCTAGTCTT 1260
GGCCAGCCAA CTCTGGGAAT ACAGGGGTGA AAGGGGGGAA CCAGTGAAAA TGAAAGGAAG 1320
TTTCAGTATT AGATGCACTT AAGTTAGCCT CCACCACCCT TTCCCCCTTC TCTTAGTTAT 1380
TGCTGAAGAG GGTTGG ATA AAAATAATTT TAAAAAAGCC TTCCTACACG TTAGATTTGC 1440
CGTACCAATC TCTGAATGCC CCATAATTAT TATTTCCAGT GTTTGGGATG ACCAGGATCC 1500
CAAGCCTCCT GCTGCCACAA TGTTTATAAA GGCCAAATGA TAGCGGGGGC TAAGTTGGTG 1560
CTTTTGAGAA CCAAGTAAAA CAAAACCACT GGGAGGAGTC TATTTTAAAG AATTCCCTTG 1620
AAAAAATAGA TCCAATCAGT TTATACCCTA GTTAGTGTTT TGCCTCACCT AATAGGCTGG 1680
GAGACTGAAG ACTCAGCCCG GGTGGGGCTG CAGAAAAATG ATTGGCCCCA GTCCCCTTGT 1740
TTGTCCCTTC TACAGGCATG AGGAATCTGG GAGGCCCTGA GACAGGGATT GTGCTTCATT 1800 CCAATCTATT GCTTCACCAT GGCCTTATGA GGCAGCTGAG AGATGTTTGA ATTTTTCTCT 1860
TCCTTTTAGT ATTCTTAGTT GTTCAGTTGC CAAGGATCCC TGATCCCATT TTCCTCTGAC 1920
GTCCACCTCC TACCCCATAG GAGTTAGAAG TTAGCGTTTA GGCATCATTT TGAGAATGCT 1980
GACACTTTTT CAGGGCTGTG ATTGAGTGAG GGCATGGGTA AAAATATTTC TTTAAAAGAA 2040
GGATGAACAA TTATATTTAT ATTTCAGGTT ATATCCAATA GTAGAGTTGG CTTTTTTTTT 2100
TTTTTTTTTG GTCATAGTCC GTGGATTTGT TGCCATGTGC ACCTTGGGGT TTTGTAATGA 2160
CAGTGCTAAA AAAAAAAAAG CATTTTTTTT TATGATTTGT CTCTGTCACC CTTGTCCTTG 2220
AGTGCTCTTG CTATTAACGT TATTTGTAAT TTAGTTTGTA GCTCATTAAA AAAATGTGCC 2280
TAGTTTTATA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAA 2328
Seq ID NO: 176 DNA Sequence
Nucleic Acid Accession It - NM_052827.ι
Coding sequence: 234..1028
1 11 21 31 41 51 i i i i i i
GGAAGCAGGG CGGGGCCTCT GGTGGCGGTC GGGAACTCGG TGGGAGGCGG CAACATTGTT 60
TCAAGTTGGC CAAATTGACA AGAGCGAGAG GTATACTGCG TTCCATCCCG ACCCGGGGCC 120
ACGGTACTGG GCCCTGTTTC CCCCTCCTCG GCCCCCGAGA GCCAGGGTCC GCCTTCTGCA 180
GGGTTCCCAG GCCCCCGCTC CAGGGCCGGG CTGACCCGAC TCGCTGGCGC TTCATGGAGA 240
ACTTCCAAAA GGTGGAAAAG ATCGGAGAGG GCACGTACGG AGTTGTGTAC AAAGCCAGAA 300
ACAAGTTGAC GGGAGAGGTG GTGGCGCTTA AGAAAATCCG CCTGGACACT GAGACTGAGG 360
GTGTGCCCAG TACTGCCATC CGAGAGATCT CTCTGCTTAA GGAGCTTAAC CATCCTAATA 420
TTGTCAAGCT GCTGGATGTC ATTCACACAG AAAATAAACT CTACCTGGTT TTTGAATTTC 480
TGCACCAAGA TCTCAAGAAA TTCATGGATG CCTCTGCTCT CACTGGCATT CCTCTTCCCC 540
TCATCAAGAG CTATCTGTTC CAGCTGCTCC AGGGCCTAGC TTTCTGCCAT TCTCATCGCG 600
TCCTCCACCG AGACCTTAAA CCTCAGAATC TGCTTATTAA CACAGAGGGG GCCATCAAGC 660
TAGCAGACTT TGGACTAGCC AGAGCTTTTG GAGTCCCTGT TCGTACTTAC ACCCATGAGG 720
TGACTCGCCG GGCCCTATTC CCTGGAGATT CTGAGATTGA CCAGCTCTTC CGGATCTTTC 780
GGACTCTGGG GACCCCAGAT GAGGTGGTGT GGCCAGGAGT TACTTCTATG CCTGATTACA 840
AGCCAAGTTT CCCCAAGTGG GCCCGGCAAG ATTTTAGTAA AGTTGTACCT CCCCTGGATG 900
AAGATGGACG GAGCTTGTTA TCGCAAATGC TGCACTACGA CCCTTACAAG AGGATTTCGG 960
CCAAGGCAGC CCTGGCTCAC CCTTTCTTCC AGGATGTGAC CAAGCCAGTA CCCCATCTTC 1020
GACTCTGATA GCCTTCTTGA AGCCCCCAGC CCTAATCTCA CCCTCTCCTC CAGTGTGGGC 1080
TTGACCAGGC TTGGCCTTGG GCTATTTGGA CTCAGGTGGG CCCTCTGAAC TTGCCTTAAA 1140
CACTCACCTT CTAGTCTTGG CCAGCCAACT CTCCGAATAC AGGGGTGAAA GGGGGGAACC 1200
AGTGAAAATG AAAGGAAGTT TCAGTATTAG ATGCACTTAA GTTAGCCTCC ACCACCCTTT 1260
CCCCCTTCTC TTAGTTATTG CTGAAGAGGG TTGGTA AAA AATAATTTTA AAAAAGCCTT 1320
CCTACACGTT AGATTTGCCG TACCAATCTC TGAATGCCCC ATAATTATTA TTTCCAGTGT 1380
TTGGGATGAC CAGGATCCCA AGCCTCCTGC TGCCACAATG TTTATAAAGG CCAAATGATA 1440
GCGGGGGCTA AGTTGGTGCT TTTGAGAACC AAGTAAAACA AAACCACTGG GAGGAGTCTA 1500
TTTTAAAGAA TTCGGTTGAA AAAATAGATC CAATCAGTTT ATACCCTAGT TAGTGTTTTG 1560
CCTCACCTAA TAGGCTGGGA GACTGAAGAC TCAGCCCGGG TGGGGCTGCA GAAAAATGAT 1620
TGGCCCCAGT CCCCTTGTTT GTCCCTTCTA CAGGCATGAG GAATCTGGGA GGCCCTGAGA 1680
CAGGGATTGT GCTTCATTCC AATCTATTGC TTCACCATGG CCTTATGAGG CAGGTGAGAG 1740
ATGTTTGAAT TTTTCTCTTC CTTTTAGTAT TCTTAGTTGT TCAGTTGCCA AGGATCCCTG 1800
ATCCCATTTT CCTCTGACGT CCACCTCCTA CCCCATAGGA GTTAGAAGTT AGGGTTTAGG 1860
CATCATTTTG AGAATGCTGA CACTTTTTCA GGGCTGTGAT TGAGTGAGGG CATGGGTAAA 1920
AATATTTCTT TAAAAGAAGG ATGAACAATT ATATTTATAT TTCAGGTTAT ATCCAATAGT 1980
AGAGTTGGCT TTTTTTTTTT TTTTTTTGGT CATAGTGGGT GGATTTGTTG CCATGTGCAC 2040
CTTGGGGTTT TGTAATGACA GTGCTAAAAA AAAAAAAGCA TTTTTTTTTA TGATTTGTCT 2100
CTGTCACCCT TGTCCTTGAG TGCTCTTGCT ATTAACGTTA TTTGTAATTT AGTTTGTAGC 2160
TCATTAAAAA AATGTGCCTA GTTTTATAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 2220
AAAAAA 2226
Seq ID NO: 177 DNA Sequence
Nucleic Acid Accession ft. NM_032738.1
Coding sequence- 118..1197
1 11 21 31 41 51
I I I I I I
GGCACGAGGG ATGCAAGGAG ATGAGACAGT TAGATTTACT TCCTCTTTTC TAATCTGAGA 60
GGTTTCATGT TGAAGAAAAT CAGTGTTGGG GTTGCAGGAG ACCTAAACAC AGTCACCATG 120
AAGCTGGGCT GTGTCCTCAT GGCCTGCCCC CTCTACCTTT CCCTTGCTGT GCTCTGGGTG 180
GCCCAGATGC TACTGGCTGC CAGTTTTGAG ACGCTGCAGT GTGAGGGACC TGTCTGCACT 240
GAGGAGAGCA GCTGCCACAC GGAGGATGAC TTGACTGATG CAAGGGAAGC TGGCTTCCAG 300
GTCAAGGCCT ACACTTTCAG TGAACCCTTC CACCTGATTG TGTCCTATGA CTGGCTGATC 360
CTCCAAGGTC CAGCCAAGCC AGTTTTTGAA GGGGACCTGC TGGTTCTGCG CTGCCAGGCC 420
TGGCAAGACT GGCCACTGAC TCAGGTGACC TTCTACCGAG ATGGCTCAGC TCTGGGTCCC 480
CCCGGGCCTA ACAGGGAATT CTCCATCACC GTGGTACAAA AGGCAGACAG CGGGCACTAC 540
CACTGCAGTG GCATCTTCCA GAGCCCTCCT CCTGGGATCC CAGAAACAGC ATCTGTTGTG 600
GCTATCACAG TCCAAGAACT GTTTCCAGCG CCAATTCTCA GAGCTGTACC CTCAGCTGAA 660
CCCCAAGCAG GAAGCCCCAT GACCCTGAGT TGTCAGACAA AGTTGCCCCT GCAGAGGTCA 720
GCTGCCCGCC TCCTCTTCTC CTTCTACAAG GATGGAAGGA TAGTGCAAAG CAGGGGGCTC 780
TCCTCAGAAT TCCAGATCCC CACAGCTTCA GAAGATCACT CCGGGTCATA CTGGTGTGAG 840
GCAGCCACTG AGGACAACCA AGTTTGGAAA CAGAGCCCCC AGCTAGAGAT CAGAGTGCAG 900
GGTGCTTCCA GCTCTGCTGC ACCTCCCACA TTGAATCCAG CTCCTCAGAA ATCAGCTGCT 960
CCAGGAACTG CTCCTGAGGA GGCCCCTCCG CCTCTGCCTC CGCCGCCAAC CCCATCTTCT 1020
GAGGATCCAG GCTTTTCTTC TCCTCTGGGG ATGCCAGATC CTCATCTGTA TCACCAGATG 1080
GGCCTTCTTC TCAAACACAT GCAGGATGTG AGAGTCCTCC TCCCTCACCT GCTCATGCAG 1140
TTGAGGGAAT TATCTGGCCA CCAGAAGCCT GGGACCACAA AGGCTACTGC TGAATAGAAG 1200
TAAACAGTTC ATCCATGATC TCACTTAACC ACCCCAATAA ATCTGATTCT TTATTTTCTC 1260
TTCCTGTCCT GCACATATGC ATAAGTACTT TTACAAGTTG TCCCAGTGTT TTGTTAGAAT 1320
AATGTAGTTA GGTGAGTGTA AATAAATTTA TATAAAGTGA GAATTAGAGT TTAGCTATAA 1380
TTGTGTATTC TCTCTTAACA CAACAGAATT CTGCTGTCTA GATCAGGAAT TTCTATCTGT 1440
TATATCGACC AGAATGTTGT GATTTAAAGA GAACTAATGG AAGTGGATTG AATACAGCAG 1500 TCTCAACTGG GGGCAATTTT GCCCCCCAGA GGACATTGGG CAATGTTTGG AGACATTTTG 1560
GTCATTATAC TTGGGGGGTT GGGGGATGGT GGGATGTGTG TGCTACTGGC ATCCAGTAAA 1620
TAGAAGCCAG GGGTGCCGCT AAACATCCTA TAATGCACAG GGCAGTACCC CACAACGAAA 1680
AATAATCTGG CCCAAAATGT CAGTTGTACT GAGTTTGAGA AACCCCAGCC TAATGAAACC 1740 CTAGGTGTTG GGCTCTGGAA TGGGACTTTG TCCCTTCTAA TTATTATCTC TTTCCAGCCT 1800
CATTCAGCTA TTCTTACTGA CATACCAGTC TTTAGCTCCT GCTATGGTCT GTTCTTTAGT 1860
TCTAGTTTGT ATCCCCTCAA AAGCCATTAT GTTGAAATCC TAATCCCCAA GGTGATGGCA 1920
TTAAGAAGTG GGCCTTTGGG AAGTGATTAG ATCAGGAGTG CAGAGCCCTC ATGATTAGGA 1980
TTAGTGCCCT TATTTAAAAA GGCCCCAGAG AGCTAACTCA CCCTTCCACC ATATGAGGAC 2040 GTGGCAAGAA GATGACATGT ATGAGAACCA AAAAACAGCT GTCGCCAAAC ACCGACTCTG 2100
TCGTTGCCTT GATCTTGAAC TTCCAGCCTC CAGAACTATG AGAAATAAAA TTCTGTTGTT 2160
TGTAAAAAAA AAAAAAAAAA A 2181
Seq ID NO 178 DNA Sequence
Nucleic Acid Accession # NM_002346 1
Coding sequence 136 531
1 11 21 31 41 51
I I I I I I
GCTCCGGCCA GCCGCGGTCC AGAGCGCGCG AGGTTCGGGG AGCTCCGCCA GGCTGCTGCT 60
ACCTGCGTCC GCCCCCCGAG CAGGACAGGC TGCTTTGGTT TGTGACCTCC AGGCAGGACG 120
GCCATCCTCT CCAGAATGAA GATCTTCTTG CCAGTGCTGC TGGCTGCCCT TCTGGGTGTG 180
GAGCGAGCCA GCTCGCTGAT GTGCTTCTCC TGCTTGAACC AGAAGAGCAA TCTGTACTGC 240
CTGAAGCCGA CCATCTGCTC CGACCAGGAC AACTACTGCG TGACTGTGTC TGCTAGTGCC 300
GGCATTGGGA ATCTCGTGAC ATTTGGCCAC AGCCTGAGCA AGACCTGTTC CCCGGCCTGC 360
CCCATCCCAG AAGGCGTCAA TGTTGGTGTG GCTTCCATGC GCATCAGCTG CTGCCAGAGC 420
TTTCTGTGCA ATTTCAGTGC GGCCGATGGC GGGCTGCGGG CAAGCGTCAC CCTGCTGGGT 480
GCCGGGCTGC TGCTGAGCCT GCTGCCGGCC CTGCTGCGGT TTGGCCCCTG ACCGCCCAGA 540
CCCTGTCCCC CGATCCCCCA GCTCAGGAAG GAAAGCCCAG CCCTTTCTGG ATCCCACAGT 600
GTATGGGAGC CCCTGACTCC TCACGTGCCT GATCTGTGCC CTTGGTCCCA GGTCAGGCCC 660
ACCCCCTGCA CCTCCACCTG CCCCAGCCCC TGCCTCTGCC CAAGTGGGCC AGCTGCCCTC 720
ACTTCTGGGG TGGATGATGT GACCTTCCTT GGGGGACTGC GGAAGGGACG AGGGTTCCCT 780
GCAGTCTTAC GGTCCAACAT CAGACCAAGT CCCATGGACA TGCTGACAGG GTCCCCAGGG 840
AGACCGTGTC AGTAGGGATG TGTGCCTGGC TGTGTACGTG GGTGTGCAGT GCACGTGAGA 900
GCACGTGGCG GCTTCTGGGG GCCATGTTTG GGGAGGGAGG TGTGCCAGCA GCCTGGAGAG 960
CCTCAGTCCC TGTAGCCCCC TGCCCTGGCA CAGCTGCATG CACTTCAAGG GCAGCCTTTG 1020
GGGGTTGGGG TTTCTGCCAC TTCCGGGTCT AGGCCCTGCC CAAATCCAGC CAGTCCTGCC 1080
CCAGCCCACC CCCACATTGG AGCCCTCCTG CTGCTTTGGT GCCTCAAATA AATACAGATG 1140
TCCCC 1145
Seq ID NO 179 DNA Sequence
Nucleic Acid Accession tt XM_113526 2
Coding sequence 253 2409
1 11 21 31 41 51
I I I I I I
TGGGCGCCGG CGGAGCGGAG CCAGATCCGA GCGGCGGCGG CAAGCTGGCT GCGAGCGGCT 60
GAGCAGCACT CCAAGCTCGC CGGCCTTTGC TCTCCAGGAC TTGTCCCAGC AGCCCCTCGA 120
ACTGAGAATT ACACCATCGG ACCCCTGGCT CTGAGGCCTT CAGACTTGGA CTGTGTCACA 180
CTGCCACCCT TCCAGGGCTC CAACTTGCAG ACGCCCTGTT GTGGGACAGT CTCTGTAATC 240
GCGAAAGCAA CCATGCAAGA CCTGGGGGAA AACACCATGG TTTTATCCAC CCTGAGATCT 300
TTGAACAACT TCATCTCTCA GCGTGTGGAG GGAGGCTCTG GACTGGATAT TTCTACCTCG 360
GCCCCAGGTT CTCTGCAGAT GCAGTACCAG CAGAGCATGC AGCTGGAGGA AAGAGCAGAG 420
CAGATCCGTT CGAAGTCCCA CCTCATCCAG GTGGAGCGGG AGAAAATGCA GATGGAGCTG 480
AGTCACAAGA GGGCTCGAGT GGAGCTGGAG AGAGCAGCCA GCACCAGTGC CAGGAACTAC 540
GAGCGTGAGG TCGACCGCAA CCAGGAGCTC CTGACGCGCA TCCGGCAGCT TCACCAGCGG 600
GAGGCCGGGG CGGAGGAGAA GATGCAGGAG CAGCTGGAGC GCAACAGGCA GTGTCAGCAG 660
AACTTGGATG CTGCCAGCAA GAGGCTGCGT GAGAAAGAGG ACAGTCTGGC CCACCCTGGC 720
GAGACCATCA ACGCACTGAA GGGGAGGATC TCGGAACTGC AGTGGAGCGT GATGGACCAG 780
GAGATGCGCG TGAAGCGCCT GGAGTCGGAG AAGCAGGAGC TGCAGGAGCA GCTGCACCTG 840
CAACACAAAA AATGCCAGGA AGCCAATCAG AAAATCCAGG AACTCCAGGC CAGCCAAGAA 900
GCAAGAGCAG ACCACGAGCA GCAGATTAAG GATCTGGAGC AGAAGCTGTC CCTGCAAGAG 960
CAGGATGCAG CGATTGTGAA GAACATGAAG TCTGAGCTGG TACGCCTCCC TAGGCTGGAA 1020
CGGGAGCTGA AGCAGCTGCG GGAGGAGAGC GCGCACCTGC GCGAGATGAG AGAGACCAAC 1080
GGGCTGCTCC AGGAAGAGCT GGAAGGGCTG CAGAGGAAGC TGGGGCGCCA GGAGAAGATG 1140
CAGGAGACGC TGGTTGGCTT GGAGCTGGAG AACGAGAGGC TGCTGGCCAA GCTGCAAAGC 1200
TGGGAGAGAC TGGACCAGAC CATGGGCCTG AGCATCAGGA CTCCAGAAGA CCTTTCCAGA 1260 TTCGTGGTTG AGCTGCAGCA GAGGGAGCTT GCCTTGAAGG ACAAGAACAG CGCCGTCACC 1320
AGCAGCGCCC GGGGGCTGGA GAAGGCCAGG CAGCAGCTGC AGGAGGAGCT CCGGCAGGTC 1380 AGCGGCCAGC TGTTGGAGGA GAGGAAGAAG CGCGAGACCC ACGAGGCGCT GGCCCGGAGG 1440
CTCCAGAAAC GGGTCCTGCT GCTCACCAAG GAGCGCGACG GTATGCGGGC CATCCTGGGG 1500 TCCTACGACA GCGAGCTGAC CCCGGCCGAG TACTCACCCC AGCTGACGCG GCGCATGCGG 1560 GAGGCTGAGG ATATGGTGCA GAAGGTGCAC AGCCACAGCG CCGAGATGGA GGCTCAGCTG 1620 TCGCAGGCCC TCCAGGAGCT GGGAGGCCAG AAACAAAGAG CAGACATGCT GGAGATGGAG 1680 CTGAAGATGC TGAAGTCTCA GTCCAGCTCT GCCGAACAGA GCTTCCTGTT CTCCAGGGAG 1740 GAGGCGGACA CGCTCAGGTT GAAGGTCGAG GAGCTGGAAG GCGAGCGGAG TCGGCTGGAG 1800 GAGGAAAAGA GGATGCTGGA GGCACAGCTG GAGCGGCGAG CTCTGCAGGG TGACTATGAC 1860 CAGAGCAGGA CCAAAGTGCT GCACATGAGC CTGAACCCCA CCAGTGTGGC CAGGCAGCGC 1920 CTGCGCGAGG ACCACAGCCA GCTGCAGCCG GAGTGCGAGC GACTGCGCGG GCTCCTGCGC 1980 GCCATGGAGA GAGGAGGCAC CGTCCCAGCC GACCTTGAGG CTGCCGCCGC GAGTCTGCCA 2040 TCGTCCAAGG AGGTGGCAGA GCTGAAGAAG CAGGTGGAGA GTGCCGAGCT GAAGAACCAG 2100 CGGCTCAAGG AGGTTTTCCA GACCAAGATC CAGGAGTTCC GCAAGGCCTG CTACACGCTC 2160 ACCGGCTACC AGATCGACAT CACCACGGAG AACCAGTACC GGCTGACCTC GCTGTACGCC 2220 GAGCACCCAG GCGACTGCCT CATCTTCAAG GCCACCAGCC CCTCGGGTTC CAAGATGCAG 2280 CTACTGGAGA CAGAGTTCTC ACACACCGTG GGCGAGCTCA TCGAGGTGCA CCTGCGGCGC 2340 CAGGACAGCA TCCCTGCCTT CCTCAGCTCG CTCACCCTCG AGCTCTTCAG CCGCCAGACC 2400 GTGGCGTAGC CTGCAGGCTC GGGGGCATAG CCCCAGCCAC TCTGCTTGGC CTGACCTGCA 2460
GGTCCCCTGC CCCGCCAGCC ACAGGCTGGG TGCACGTCCT GCCTCTCCAG CCCCACACCG 2520
CAGCAGCATG ACTGACAGAC ACGCTGGGAC CTACGTCGGG CTTCCTGCTG GGGCGGCCAG 2580
CACCCTCTCC ACGTGCAGAC CCCATGCGTC CCGGAGCCTG GTGTGTGGGC GTCGGCCACC 2640
AGCCTGGGTT CCTCACCTTG TGAAATAAAA TCTTCTCCCC TAG 2683
Seq ID NO 180 DNA Sequence
Nucleic Acid Accession tt NM_000273 1
Coding sequence 1 1275
1 11 21 31 41 51
I I I I I I
ATGACCCAGG CAGCCCGGCG GGGTCCTCCC ACACCCGAGC CGCGTCCGCG AACACAGCCC 60
ATGGCCTCCC CGCGCCTACC GACCTTCTGC TGCCCCACGC GGGACGCAGC CACGCAGCTC 120
GTGCTGAGCT TCCAGCCGCG GGCCTTCCAC GCGCTCTGCC TGGGCAGCGG CGGGCTCCGC 180
TTGGCGCTGG GCCTTCTGCA GCTGCTGCCC GGCCGCCCCC CCGCGGGCCC CGGGTCCCCC 2 0
GCGACGTCCC CGCCCCCCTC GGTCCGCATC CTGCGCGCTG CCGCTGCCTG CGACCTTCTC 300
GGCTGCCTGG GTATGGTGAT CCGGTCCACC GTGTGGTTAG GATTCCCAAA TTTTGTTGAC 360
AGCGTCTCCC ATATGAACCA CACGGAAATT TGGCCTGCTG CTTTCTGCGT GGGGAGTGCG 420
ATGTGGATCC AGCTGTTGTA CAGTGCCTGC TTCTGGTGGC TGTTTTGCTA TGCAGTGGAT 480
GCTTATCTGG TGATCCGGAG ATCGGCAGGA CTGAGCACCA TCCTGCTGTA TCACATCATG 540
GCGTGGGGCC TGGCCACCCT GCTCTGTGTG GAGGGAGCCG CCATGCTCTA CTACCCTTCC 600
GTGTCCAGGT GTGAGCGGGG CCTCCACCAC GCCATCCCCC ACTATGTCAC CATGTACCTG 660
CCCCTGCTGC TGGTTCTCGT GGCGAACCCC ATCCTGTTCC AAAAGACAGT GACTGCAGTG 720
GCCTCTTTAC TTAAAGGAAG ACAAGGCATT TACACGGAGA ACGAGAGGAG GATGGGAGCC 780
GTGATCAAGA TCCGATTTTT CAAAATCATG CTGGTTTTAA TTATTTGTTG GTTGTCGAAT 840
ATCATCAATG AAAGCCTTTT ATTCTATCTT GAGATGCAAA CAGATATCAA TGGAGGTTCT 900
TTGAAACCTG TCAGAACTGC AGCCAAGACC ACATGGTTTA TTATGGGAAT CCTGAATCCA 960
GCCCAGGGAT TTCTCTTGTC TTTGGCCTTC TACGGCTGGA CAGGATGCAG CCTGGGTTTT 1020
CAGTCTCCCA GGAAGGAGAT CCAGTGGGAA TCACTGACCA CCTCGGCTGC TGAGGGGGCT 1080
CACCCATCCC CACTGATGCC CCATGAAAAC CCTGCTTCCG GGAAGGTGTC TCAAGTGGGT 1140
GGGCAGACTT CTGACGAAGC CCTGAGCATG CTGTCTGAAG GTTCTGATGC CAGCACAATT 1200
GAAATTCACA CTGCAAGTGA ATCCTGCAAC AAAAATGAGG GTGACCCTGC TCTCCCAACC 1260
CATGCAGACC TATGAAGGGG ATGTGCTGGG GGTCCAGACC CCATATTCCT CAGACTCAAC 1320
AATTCTTGTT CTTTAGAACT GTGTTCTCAC CTTCCCAACA CTGCACTGCC GAAGTGTAGC 1380
GGCCCCCAAA CCTTGCTCTC ATCACCAGCT AGAGCTTCTT CCCGAAGGGC CTTTAGGATA 1440
GGAGAAAGGG TTCATGCACA CACGTGTGAG AATGGAAGAG CCCCCTCCAG ACCACTCTAC 1500
AGCTGCTCTA GCCTTAGTTG CCACTAGGAA GTTTTCTGAG GCTGGCTGTA AAGTAAGTGT 1560
AAGGTCCACA TCCTTGGGGA AGTAGTTAAA TAAAATAGTT ATGACTG 1607
Seq ID NO 181 DNA Sequence
Nucleic Acid Accession # NM_139317 1
Coding sequence 174 1070
1 11 21 31 41 51
I I I I I I
CCCTGGGATA CTCCCCTCCC AGGGTGTCTG GTGGCAGGCC TGTGCCTATC CCTGCTGTCC 60
CCAGGGTGGG CCCCGGGGGT CACCAGCTCC AGAAGGGCCA GCTGGGCATA TTCTGAGATT 120
GGCCATCAGC CCCCATTTCT GCTGCAAACC TGGTCAGAGC CAGTGTTCCC TCCATGCGAC 180
CTAAAGACAG TGCCAAGTGC CTGCACCGTG GACCACAGCC GAGCCACTGG GCAGCCGGTG 240
ATGGTCCCAC GCAGGAGCGC TGTGGACCCC GCTCTCTGGG CAGCCCTGTC CTAGGCCTGG 300
ACACCTGCAG AGCCTGGGAC CACGTGGATG GGCAGATCCT GGGCCAGCTG CGGCCCCTGA 360
CAGAGGAGGA AGAGGAGGAG GGCGCCGCGG CCACCTTGTC CAGGGGGCCT GCCTTCCCCG 420
GCATGGGCTC TGAGGAGTTG CGTCTGGCCT CCTTCTATGA CTGGCCGCTG ACTGCTGAGG 480
TGCCACCCGA GCTGCTGGCT GCTGCCGGCT TCTTCCACAC AGGCCATCAG GACAAGGTGA 540
GGTGCTTCTT CTGCTATGGG GGCCTGCAGA GCTGGAAGCG CGGGGACGAC CCCTGCACGG 600
AGCATGCCAA GTGGTTCCCC AGCTGTCAGT TCCTGCTCCG GTCAAAAGGA AGAGACTTTG 660
TCCACAGTGT GCAGGAGACT CACTCCCAGC TGCTGCGCTC CTGGGACCCG TGGGAAGAAC 720
CGGAAGACGC AGCCCCTGTG GCCCCCTCCG TCCCTGCCTC TGGGTACCCT GAGCTGCCCA 780
CACCCAGGAG AGAGGTCCAG TCTGAAAGTG CCCAGGAGCC AGGAGGGGTC AGTCCAGCCG 840 AGGCCCAGAG GGCGTGGTGG GTTCTTGAGC CCCCAGCAGC CAGGGATGTG GAGGCGCAGC 900 TdCGGCGGCT GCAGGAGGAG AGGACGTGCA AGGTGTGCCT GGACCGCGCC GTGTCCATCG 960
TCTTTGTGCC GTGCGGCCAC CTGGTCTGTG CTGAGTGTGC CCCCGCCCTG CAGCTGTGCC 1020
CCATCTGCAG AGCCCCCGTC CGCAGCCGCG TGCGCACCTT CCTGTCCTAG GCCAGGTGCC 1080
ATGGCCCCCC AGGTGGGCTG CAGAGTGGGC TCCCTGCCCC TCTCTGCCTG TTCTGGACTG 1140
TGTTCTGGGC CTGCTGAGGA TGGCAGAGCT GGTGTCCATC CAGCACTGAC CAGCCCTGAT 1200
TCCCCGACCA CCGCCCAGGG TGGAGAAGGA GGCCCTTGCT TGGCGTGGGG GATGGCTTAA 1260
CTGTACCTGT TTGGATGCTT CTGAATAGAA ATAAAGTGGG TTTTCCCTGG AGGTACCCAG 1320
CA 1322
Seq ID NO 182 DNA Sequence
Nucleic Acid Accession It NM_022161 2
Coding sequence 174 1016
1 11 21 31 41 51
I I I I I I
CCCTGGGATA CTCCCCTCCC AGGGTGTCTG GTGGCAGGCC TGTGCCTATC CCTGCTGTCC 60
CCAGGGTGGG CCCCGGGGGT CAGGAGCTCC AGAAGGGCCA GCTGGGCATA TTCTGAGATT 120
GGCCATCAGC CCCCATTTCT GCTGCAAACC TGGTCAGAGC CAGTGTTCCC TCCATCCGAC 180
CTAAAGACAG TGCCAAGTGC CTGCACCGTG GACCACAGCC GAGCCACTGG GCAGCCGGTG 240
ATGGTCCCAC GCAGGAGCGC TGTGGACCCC GCTCTCTGGG CAGCCCTGTC CTAGGCCTGG 300
ACACCTGCAG AGCCTGGGAC CACGTGGATG GGCAGATCCT GGGCCAGCTG CGGCCCCTGA 360
CAGAGGAGGA AGAGGAGGAG GGCGCCGCGG CCACCTTGTC CAGGGGGCCT GCCTTCCCCG 420
GCATGGGCTC TGAGGAGTTG CGTCTGGCCT CCTTCTATGA CTGGCCGCTG ACTGCTGAGG 480
TGCCACCCGA GCTGCTGGCT GCTGCCGGCT TCTTCCACAC AGGCCATCAG GACAAGGTGA 540
GGTGCTTCTT CTGCTATGGG GGCCTGCAGA GCTGGAAGCG CGGGGACGAC CCCTGCACGG 600
AGCATGCCAA GTGGTTCCCC AGCTGTCAGT TCCTGCTCCG GTCAAAAGGA AGAGACTTTG 660 TCCACAGTGT GCAGGAGACT CACTCCCAGC TGCTGGGCTC CTGGGACCCG TGGGAAGAAC 720
CGGAAGACGC AGCCCCTGTG GCCCCCTCCG TCCCTGCCTC TGGGTACCCT GAGCTGCCCA 780
CACCCAGGAG AGAGGTCCAG TCTGAAAGTG CCCAGGAGCC AGGAGCCAGG GATGTGGAGG S40
CGCAGCTGCG GCGGCTGCAG GAGGAGAGGA CGTGCAAGGT GTGCCTGGAC CGCGCCGTGT 900 CCATCGTCTT TGTGCCGTGC GGCCACCTGG TCTGTGCTGA GTGTGCCCCC GGCCTGCAGC 960
TGTGCCCCAT CTGCAGAGCC CCCGTCCGCA GCCGCGTGCG CACCTTCCTG TCCTAGGCCA 1020
GGTGCCATGG CCGGCCAGCT GGGCTGCAGA GTGGGCTCCC TGCCCCTCTC TGCCTGTTCT 1080
GGACTGTGTT CTGGGCCTGC TGAGGATGGC AGAGCTGGTG TCCATCCAGC ACTGACCAGC 1140
CCTGATTCCC CGACCACCGC CCAGGGTGGA GAAGGAGGCC CTTGCTTGGC GTGGGGGATG 1200 GCTTAACTGT ACCTGTTTGG ATGCTTCTGA ATAGAAATAA AGTGGGTTTT CCCTGGAGGT 1260
ACCCAGCA 1268
Seq ID NO. 183 DNA Sequence Nucleic Acid Accession If: NM_021020.1 Coding sequence: 112..1902
1 11 21 31 41 51
TGAGGGCTTT GCTATGACCT CAGTCCCCTC ACGGAGCCAC GACTGCCCCT TGCTGCCACA 60
GCCTTTCCAA GACCCTGCCC GGCCCTGCCC CATCCTCAGC CCCGAGTCAC CATGGGCAGC 120
GTCAGTAGCC TCATCTCCGG CCACAGCTTC CACAGCAAGC ACTGCCGGGC TTCGCAGTAC 180
AAGCTGCGCA AGTCCTCCCA CCTCAAGAAG CTCAACCGGT ATTCCGACGG GCTGCTGAGG 240
TTTGGCTTCT CCCAGCACTC CGGTCACGGC AAGTCCAGCT CCAAAATGGG CAAGAGCGAA 300
GACTTCTTCT ACATCAAGGT CAGCCAGAAA GCCCCCGGCT CCCATCACCC AGATTACACG 360
GCACTGTCCA GCGGGGATTT AGGGGGCCAG GCTGGGGTGG ACTTTGACCC GTCCACACCC 420
CCCAAGCTCA TGCCCTTCTC CAATCAGCTA GAAATGGGCT CCGAGAAGGG TGCAGTGAGG 480
CCCACAGCCT TCAAGCCTGT GCTGCCACGG TCAGGAGCCA TCCTGCACTC CTCCCCGGAG 540
AGTGCCAGCC ACCAGCTGCA CCCCGCCCCT CCAGACAAGC CCAAGGAGCA GGAGCTGAAG 600
CCTGGCCTGT GCTCTGGGGC GCTGTCAGAC TCCGGCCGGA ACTCCATGTC CAGCCTGCCC 660
ACACACAGCA CCAGCAGCAG CTACCAGCTG GACCCGCTCC TCACACCCGT GGGACCCACA 720
AGCCGTTTTG GGGGCTCCGC CCACAACATC ACCCACCGCA TCGTCCTCCA GGACAGCAAC 780
ATGATGAGCC TGAAGGCTCT GTCCTTCTCC GACCCAGGTA GCAAGCTGGG CCACTCGAAC 840
AAGGCAGACA AGGGCCCCTC GTGTGTCCGC TCCCCCATCT CCACGGACGA GTGCAGCATC 900
CAGGAGCTGG AGCAGAAGCT GTTGGAGAGG GAGGGCGCCC TCCAGAAGCT GCAGCGCAGC 960
TTTGAGGAGA AGGAGCTTGC CTCCAGCCTG GCCTACGAGG AGCGGCCGCG GCGCTGCAGG 1020
GACGAGCTGG AGGGCCCGGA GCCCAAAGGC GGCAACAAGC TCAAGCAGGC CTCGCAGAAG 1080
AGCCAGCGCG CGCAGCAGGT CCTGCACCTG CAGGTACTGC AGCTTCAGCA GGAGAAGCGG 1140
CAGCTCCGGC AGGAGCTCGA GAGCCTCATG AAGGAGCAGG ACCTGCTGGA GACCAAGCTC 1200
AGGTCCTACG AGAGGGAGAA GACCAGCTTC GGCCCCGCGC TGGAGGAGAC CCAGTGGGAG 1260
GTGTGCCAGA AGTCAGGCGA GATCTCCCTC CTGAAGCAGC AGCTGAAGGA GTCCCAGACG 1320
GAGGTGAACG CCAAGGCTAG CGAGATCCTG GGTCTCAAGG CACAGCTGAA GGACACGCGG 1380
GGCAAGCTGG AGGGCCTGGA GCTGAGGACC CAGGACCTGG AGGGCGCCCT GCGCACCAAG 1440
GGCCTGGAGC TGGAGGTCTG TGAGAATGAG CTGCAGCGCA AGAAGAACGA GGCGGAGCTG 1500
CTGCGGGAGA AGGTGAACCT GCTGGAGCAG GAGCTGCAGG AGCTGCGGGC CCAGGCCGCC 1560
CTGGCCCGCG ACATGGGGCC GCCCACCTTC CCCGAGGACG TCCCTGCCCT GCAGCGGGAG 1620
CTGCAGCGGC TGCGGGCCGA GCTGCGGGAG GAGCGGCAAG GCCATGACCA GATGTCCTCG 1680
GGCTTCCAGC ATGAGCGGCT CGTGTGGAAG GAGGAGAAGG AGAAGGTGAT TCAGTACCAG 1740
AAACAGCTGC AGCAGAGCTA CGTGGCCATG TACCAGCGGA ACCAGCGCCT GGAGAAGGCC 1800
CTGCAGCAGC TGGCACGTGG GGACAGCGCC GGGGAGCCCT TGGAGGTTGA CCTGGAAGGG 1860
GCTGACATCC CCTACGAGGA CATCATAGCC ACTGAGATCT GAGGGGCTGC CTGGGAAGGC 1920
GAGTCTGGGG ACCTGGCACT GGGAGGCAGG GCTCTCCCGT GCATCCCCCC TGCTCAGCAA 1980
TTCAGACCCC TCTGAGAGAC GCCACTCCCT GGCACACAGA CCCACCACCC CCGAGGGGAG 2040
GGCAGGATGG CCTTTCCTTC CCTCTCTGAT GTCCCAGTGC TCACCAGCCC TGCAGCCCAC 2100
CAGACGTCAG GCCCTGACTC CTCTGGCTTT CCCAGGAGAT GGGTCCAGGG GTCTGTCTGC 2160
TTTGGTTAAG GGCTCCCTAA ACTTTGGCCT TTGTTCGAAA TAGATATCCT CTCCCCCTCC 2220
TCCAGCCAAG GTGGCCACAG CAAGAACAGC GGCTCCCCTC CGCTTCTCAT CCCAACCTCT 2280
TTTTCCTCCT GGACACATTG GAATGCCTTG GAAATAGAAA GAAGCCATAT ATGACCAGAA 2340
GCCTTGGAAC CAGCCCCATC AGAACCTGAG CTATTTTCCT CTGGCCGCAG AGGTGTAGGG 2400
GTGGAATGAG CCGCGGGGAA GCTGGCTTTG AAACCTCAGG GCTGTCCCAG CCCCGGCAAG 2460
CCACAGGAAG GAGGGGAGAG ACAGGCAGCC CAGCAGTGTG GAGACCCTGC CACAGCCAGA 2520
GGAGGGCAGA GGGAGAATCC AAGGGTTGAG AGCCAGTGGC GGGTGATGGC CAGCCCCTGG 2580
GCCCCAGCCC CTGTTTACTG GTTCTTGCAA ATGGGAGCTG AGCAGCCTCT GGACAGCCAG 2640
TGACCTTTGA CCTCGGTGAC CACTCTTCTT TAAGCCATAG ACCCTGAGGC CCTGGGCTGG 2700
GTGCTGGGAA GGGAGGGTTG AAACCACCGT GAACCAGAGG GTGTGGCTTT CCAGGCACCC 2760
TCAGGGAGCC TCCCCATCTG TCCAGCTGGG GCCAGAGGCT GGGAGTCCCT ACCTGCTTCA 2820 CGTTGGCCGG CGGCTACTCT GGAATGTTTT TCCCTCCCCA GAATCAAGCT TTTGCTTGAT 2880
CCAGAAGAGC CCATATCACT AAGATGGCAT ATATGTGATC TGGGCATTTT CCTCCTCTGC 2940
CTACAGCCAG GTTTAGCGGC AAACCTTTCC CCCTTAGCAC CTTCAGGGCT GAGTTCTGGG 3000
TTTCTAGAGG TCAGGACGGC TCCTCAGAGC GCCAGGAAGC CAGAGCCCCA AGCAGGACGA 3060
AAAAGAGGCA TACACACAGC AGTGTGAATA GCCTGGCCAC CAGCCATCCT CCCTCCACCT 3120
CAAGACCCCC ATTTGTCCCA GACTAAAGGA TCCAGAGAGC AGCTCCCTTT CTCAGGAGCT 3180
TGGGCAGTGC CCCAGGGAGT CCAGGGTTTC TCTGCAGATG TGCGCAGCGG GAGGCGGTGG 3240
TAGAGAGAGA TAAAAGGTGG AGTTTCTCTG TTGTTTGGTT CAGGGATTTT ATTTTTAATT 3300
TTATGAGACA GGGTCTTGCT CTGTCCCCCA GGCTGGAGTG CAGTGGCATG ATCATAGCTC 3360
ACTGCAGCCT CATACTCCTG GGCTCAAGCA ATCCTCCTGC CTCAGCCTTC CAACTAGCTG 3420
GGACTACAGG TGCGCGCCAC CGTGCCTGCC TAACTTTTCA TTTTTTTTGT AGGGACGGGG 3480
TCTCGTTTTG TTGCCAAAGC TGGTCTCAAA CTTGTGGCCT CAAGCAATCC ACCTGCCTTG 3540
GCCTCCCAAA GTGCTGAGAT TGCAGATGTG AGCCACCGTG CCTGGCCAGA TTTTTCTTTT 3600
ATTCTTCTTT CTTTTTCTTT TTTGCTTTCT TGTCTTTTCA GAAGCAAGCC AGACCTAGCA 3660
GGCTGTTCCA TGTTCTATTT TTGACTGTAG CCACAGCTGC TGTTCTCAGG ACAGCATCCC 3720
TTCCCACATG CCTGCGCCTG CTGCCTGCTG AGATGAGGAG GGGAGCGTCT GGGAACTTGC 3780
GAGTCCAAGC CCAGTCCCCA TTTCTGCCTC GCTCACCGCT GGCCCTTAGA GACCCCGAGG 3840
TAGGGGTGGG GAGATGCTTC TCTCCTTGCC CCCCGCCCTC ATGGGTCCTA GCCCTTCCCT 3900
GAGTGCGGGC TGAGGCCAGA GTCACCTTTT CTGTGGCTGG CTCTACCTTC CTGTCCCTGA 3960
GGTTAAACGG TGCCCATCCT GCCATCCTCA AACGACAGAG GAGCTTTTCT GGAATTTCAA 4020 ACCATTGCTC TTAGTCCCAA GCTAGGCTTA AACCTGGAAT CTACAAGCCA AAAGTCCCTC 4080
CCTGCCTGAG GGCAGTACCC TCCATTGGGC ACAGTCCAGA CCCAAGTCAA AGATGCCCCA 4140
TTCCTTGCGC CTCAGCCCTC AGTTCCTTCA TTTCCACCAG GCCGTGCCTT GTTTGAGTTT 4200
TTCCTCCCAG TGAGACTGCC CCACGGAGAC AGAGGAAAGG GCTGGCTCCC CCTCCCCAGG 4260
CTGGAGACCC CCCCCAACTC CAGGAAAGAG CAGTCAGAGT CCAGTGCTCT GCCTCAGACG 4320
TTGCCTGAGA AGAAGTGGCT GCCACACCCA GGGGAAGGCC CTGAGGCGGA GGCTGTGCTC 4380
CGCCATGGTG TCCCGGTACC TTCCATACAC AGAGGAGTGC AGCCTTCTCC ATATCTCCAT 4440
GGCCCTGTCC CAGGCCGGCC CAGATGTGTC CCCCCCAGGC CTTGTCCTAC GTCCAAGGTG 4500
GCAGATGTCT TCCCTGGGCT GCCACCAGCC CCCGCCCCAG AGTGGCCCAC CGTGGCACTA 4560
GAATGCAAGT ATCCTGCGAC CTTGCAACCT CACCTTCCTG TGGGTGTTCT TTCCTGCCCT 4620
GTCCAAAAGC GCCCTCACTA TTCTTGGACC ATGCCAGATT CTGCCTCTCT GGAAAGAGGC 4680
TCTCCACAGC AGAAGCCTCC AAGCACAGAG CCTGCCCCCA GGCCCCAGAC AGGGTGGGCT 4740
TCCTGCCCTT CCCTCTGGGC ACGCCTGCTG GCCGACCCAC TGACCCACTC GGATGGACCA 4800
ACCTGCTCTG TCCCCAAAGG ACGCCTGCAG GAGAGAGCAG CACTCCGCAT CACCTCACCA 4860
AGGATCGGAC TCTGCCCCTG GACCTGGGAA CGACTGGACT GTCACGGGGT TCCCTCCTAG 4920
CTCTCCCAGT GAACTCCTGC CAGGCACACA CAGCCCCTAT AGCACTGAGC TCACATGGGA 4980
CTGGGATATG GGGGCATCTC TTCCCCAGAG AGGCACTCAG TGAGCCTCCT GTGCCTGGCC 5040
CCAGTCTGGG CCATCTCTTA GGTGAGACAG TTGCCCGAAA CTAAGCCAGG CCTGGCTGGA 5100
GGAGCAGCAG CTTGGGGAGA GGGATTTCCC TGCAGACCTC AAGCCATCAT GCGGTGGGTG 5160
CTGCCATGAC AGAGGCTGCA CCCCTGGGCC AGCGGGGCTG CTCACCCACC TCTTGTGCAA 5220
GGTGGCCTTT GTGCTGCGCC TGCAGGCAGA GCTGGAGCCC CCAGCAGAGG CAGGCTGGGA 5280
CGGACCAGCA TCTGGAAGAT GTACATAGTT ATTTTTCTCT TTGTGGTTTC TTGTTTGGTT 5340
TGGTTTGCTT TTGACAGCTT CATTTTATTT TTGACGTCAC TTTTTGGCCA TGTAAACTAT 5400
TTGTGGCAAT TTTATGTTTT TATTTATGAA TAAAGAATGC CATTTCTCAC GCCCTCTAAA 5460
AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AA 5492
Seq ID NO 184 DNA Sequence Nucleic Acid Accession tt AF265577 Coding sequence 1 2193 1 11 21 31 41 51 l l l l 1 I 1
ATGCCCAAAA ATAGCAAGGT CCTAAAAAGA GAATTAGATG ATGATGTTAC TGAGTCTGTC 60 AAAGACCTTC TTTCCAATGA AGACGCAGCT GATGATGCTT TTAAGACAAG TGAACTAATT 120 GTTGATGGCC AGGAAGAGAA AGATACAGAT GTTGAAGAAG GATCTGAAGT CGAAGATGAA 180 AGACCAGCTT GGAACAGTAA ACTACAATAC ATCCTGGCCC AAGTTGGATT TTCTGTAGGT 240 TTAGGAAATG TGTGGCGATT TCCATACCTA TGTCAGAAGA ATGGGGGCCG TGCATATCTT 300 TTACCATATT TAATACTACT TATGGTAATA GGTATTCCCC TTTTTTTCTT GGAACTCTCT 360 GTGGGTCAAA GAATTCGGCG AGGCAGCATT GGTGTATGGA ATTACATAAG CCCTAAACTG 420 GGCGGGATTG GATTTGCAAG TTGTGTAGTG TGCTATTTTG TAGCTCTCTA CTACAACGTC 480 ATCATTGGCT GGAGTTTGTT TTATTTTTCT CAGTCTTTTC AGCAACCCCT GCCTTCCGAT 540 CAGTGTCCTT TGGTGAAAAA TGCTTCACAC ACTTTTGTAG AACCAGAATG TGAACAAAGT 600 TCTGCCACCA CCTATTACTG GTACAGGGAA GCACTGAATA TTTCAAGTTC CATTTCTGAA 660 AGTGGGGGCT TAAACTCCAA GATGACCATC TGCTTGTTGG CTGCCTGGGT CATGGTTTGC 720 TTGGCTATGA TCAAAGGCAT TCAGTCTTCT GGAAAAATCA TATATTTTAG TTCTCTGTTT 780 CCATATGTGG TACTTATTTG CTTCCTCATC AGAGCATTCC TTTTAAATGG TTCAATTGAT 840 GGCATTCGCC ACATGTTTAC CCCTAAGCTT GAAATAATGC TGGAGCCCAA GGTCTGGAGA 900 GAAGCTGCTA CTCAAGTGTT CTTTGCCTTA GGTCTGGGAT TTGGTGGTGT CATTGCCTTT 960 TCAAGCTACA ACAAGAGAGA CAACAACTGC CACTTTGATG CTGTCCTGGT GTCCTTCATC 1020 AATTTTTTCA CTTCTGTCCT GGCAACATTG GTGGTGTTTG CAGTTCTGGG CTTCAAAGCA 1080 AATGTCATAA ATGAGAAATG CATTACACAA AATTCAGAGA CGATCATGAA ATTTTTGAAA 1140 ATGGGGAACA TTAGTCAGGA TATTATTCCC CATCATATCA ACCTTTCAAC TGTTACTGCA 1200 GAAGATTATC ATTTAGTTTA TGACATCATT CAAAAAGTGA AAGAAGAAGA GTTTCCTGCT 1260 CTTCATCTCA ATTCCTGTAA AATTGAAGAA GAGCTAAATA AAGCTGTTCA GGGGACCGGC 1320 TTAGCTTTTA TTGCCTTTAC AGAAGCGATG ACACATTTTC CTGCATCTCC CTTCTGGTCA 1380 GTGATGTTTT TCCTCATGCT GCTCAATCTA GGCCTTGGCA GTATGTTTGG AACCATTGAA 1440 GGGATTGTCA CGCCTATTGT GGACACTTTC AAAGTGAGGA AAGAAATTCT TACTGTTATC 1500 TGTTGTCTTC TGGCATTTTG TATTCCCCTG ATATTTGTGC AACGCTCTGG AAATTACTTT 1560 GTTACAATGT TTGATGATTA TTCTGCTACA CTGCCTCTGC TAATTGTAGT CATTTTGGAG 1620 AATATTGCTG TATGCTTTGT TTATGGCATA GATAAGTTTA TGGAAGACCT AAAAGATATG 1680 CTGGGCTTTG CTCCCAGCAG ATATTACTAC TATATGTGGA AATATATTTC TCCTCTAATG 1740 CTATTATCAT TGCTAATAGC TAGTGTTGTG AATATGGGAT TAAGTCCTCC TGGCTATAAC 1800 GCATGCATTG AAGATAAGGC ATCTGAAGAA TTTCTGAGCT ATCCAACATG GGGACTGGTT 1860 GTTTGTGTCT CTCTGGTTGT CTTTGCAATA CTCCCAGTCC CTGTAGTTTT CATTGTTCGT 1920 CGCTTCAACC TTATAGATGA TAGTTCTGGT AATTTAGCAT CTGTGACCTA TAAGAGAGGA 1980 AGGCTCCTGA AAGAGCCTGT GAACTTAGAG GGCGATGATA CAAGCCTCAT TCACGGAAAA 2040 ATACCGAGCG AGATGCCATC TCCAAATTTT GCTAAAAATA TTTATCGAAA ACAGAGTGGA 2100 TCCCCAACTC TGGATACTGC TCCCAATGGA CGGTATGGAA TAGGGTACTT GATGGCAGAT 2160 ATTATGCCAG ATATGCCAGA ATCTGATTTG TAG 2193
Seq ID NO IBS DNA Sequence
Nucleic Acid Accession tt NM_031945 1
Coding sequence 65 1132
1 11 21 31 l l l l
CACAGAGGAG CCAGCGAACC TCTCCCGGCG CCTGTTCTGG GGGCTTTCTG TTCCAGCGTC 60 AAGGATGGAG GAGGGGGAGA GGAGCCCCTT ACTGTCCCAG GAAACTGCAG GCCAGAAGCC 120 CCTCTCTGTG CACAGGCCAC CCACCTCAGG CTGCCTAGGT CCAGTGCCCA CCGAGGACCA 180 GGCGGAGGCC TGCCGCTGCA GCTGCTGTCC CCCCCAGACC AAGCACCACC CCTTGAGTGG 240 CACTCCCAAG AAAGGACCAG CCCCTTCCCT CTCCCCAGGG AGCAGCTGCG TCAAGTATCT 300 GATCTTCCTC TCCAACTTCC CCTTCTCCCT GCTCCGGCTG CTGGCCCTGG CCATCGGGCT 360 CTGGGGCCTG GCTGTCAAGG GGTCTCTGGG AAGTGATCTG GGGGGGCCCC TGCCCACAGA 420 CCCCATGCTG GGGCTGGCAC TGGGAGGGCT GGTGGTCAGC GCAGCGAGCC TGGCTGGCTG 480 CCTGGGCGCC CTCTGCGAGA ACACCTGCCT GTTACGTGGC TTCTCCGCCG GCATCCTTGC 540 CTTCCTGGTG CTTGAGGCCG TGGCGGGGGC CCTGGTGGTG GCCCTCTGGG GCCCGCTGCA 600 AGACAGCCTG GAGCACACCC TGCGTGTGGC CATCGCCCAC TACCAGGACG ACCCAGACCT 660
GCGCTTCCTC CTCGACCAAG TCCAGCTCGG GCTGAGGTGC TGCGGAGCTG CCTCCTACCA 720
GGACTGGCAG CAGAACCTGT ACTTTAACTG CAGCTCCCCC GGGGTGCAGG CCTGCAGCCT 780
TCCCGCCTCC TGCTGCATCG ACCCCCGCGA AGATGGAGCC TCTGTCAACG ACCAGTGCGG 840 CTTCGGGGTC CTGCGCCTGG ATGCGGACGC AGCTCAGAGA GTGGTGTACC TGGAGGGCTG 900
CGGCCCGCCG CTCCGGCGGT GGCTGCGCGC GAACCTCCCT GCCTCGGGCG GCTACGCAAT 960
CGCGGTGGTG CTGCTGCAGG GGGCGGAGCT CCTGCTGGCC GCCCCCCTAC TCGGGGCCCT 1020
CGCTGCCCGC AGTGGGGCGG CGTACGCCCC CGGAGCGCAC CCGGAGGACC GCGCTGGCCC 1080
CCAGAGCCCC AGCCCCCCCG CCCCGCCCGC TGCCAAACCC GCCCCCGGCT GAGCGCACGC 1140 CCCGAGGTCC GAGACCGCCA CGCACAGGGA TACAGGGGCC GCCTCCGCCC GGCTAAAAAG 1200
CGCTGCCTGC GCCGCCGCCG CCGCCTGATT TCGCTCGGGC TTCGGGTGAC TTCGCCGCAG 1260
GACCTACCCA GCTCGCTCAC TTCGCTCGCT CCGCGTCCCC CATGCCAGCC CCCAACGCAG 1320
GGCGCCCGGC GAAGCCACGG GACTGGCCCG AGGAGCACGC GGGGCCGGAG GAAATCCTGG 1380
AGCTGACCCT CACCTCCGAG CCCCCACTCC CACCCCAGCC GCACAGTTCC CACCTCCTGG 1440 CACCTCCCTC CCCTGGGGCC GCCACCCCTT CTGCGCTCGT GATGGTGGAG CTAAGGTCCA 1500
GGCCTCTCCC TCCCGAGTGC ATTTTTGGGG AGATAG AAA TGTTTTATTC GGGTGTATCA 1560
TTCATACAGT AAAGACACCA ATCTTCAAAA AAAAAAAAAA A 1601
Seq ID NO 186 DNA Sequence
Nucleic Acid Accession tt AF475085 1
Coding sequence 54 1715
1 11 21 31 41 51
I I I I I I
GCGCCCTCGC CGCGGACACC GGAGCTGCGC CCGCTCCCCG CTGTCCCCCA GAGATGGCAG 60
ATCCTGAGGT AGTTGTGAGT AGCTGCAGCT CTCATGAAGA GGAAAATCGC TGCAATTTTA 120
ACCAGCAAAC ATCTCCATCT GAGGAGCTTC TATTAGAAGA CCAGATGAGG CGAAAACTCA 180
AATTTTTTTT CATGAATCCC TGTGAGAAGT TCTGGGCTCG AGGTAGAAAA CCATCCAAAC 240
TTGCCATACA AATTCTAAAA ATTGCAATGG TGACTATCCA GCTGGTCTTA TTTGGGCTAA 300
GTAACCAGAT GGTGGTAGCT TTCAAGGAAG AGAATACTAT AGCATTCAAA CACCTTTTCC 360
TAAAAGGATA TATGGACCGA ATGGATGACA CATATGCAGT GTACACACAA AGTGACGTGT 420
ATGATCAGTT AATCTTCGCA GTAAACCAGT ACTTGCAGCT ATACAATGTC TCCGTTGGGA 480
ATCATGCTTA TGAGAACAAA GGTACCAAGC AATCTGCTAT GGCAATCTGT CAGCACTTCT 540
ACAAGCGAGG AAACATCTAC CCTGGAAATG ATACCTTTGA CATCGATCCA GAAATTGAAA 600
CTGAGTGTTT CTTTGTGGAG CCAGATGAAC CTTTTCACAT TGGGACACCA GCAGAAAATA 660
AACTGAACTT AACACTGGAC TTCCACAGAC TCCTAACAGT GGAGCTTCAG TTTAAACTGA 720
AAGCCATTAA TCTGCAGACA GTTCGTCATC AAGAACTCCC TGACTGTTAT GACTTTACTC 780
TGACTATAAC ATTTGACAAC AAGGCCCATA GTGGAAGAAT TAAAATAAGT TTAGATAATG 840
ACATTTCCAT CAGAGAATGT AAAGACTCCC ATGTATCTGG ATCAATTCAG AAGAACACTC 900
ATTACATGAT GATCTTTGAT GCCTTTGTCA TTCTGACTTG CTTCCTTTCA TTAATCCTCT 960
GCATTAGATC TGTGATTAGA GGACTTCAGC TTCAGCAGGA GTTTGTCAAT TTTTTCCTCC 1020
TCCATTATAA GAAGGAAGTT TCTGTTTCTG ATCAAATCCA ATTTGTCAAT GGATGGTACA 1080
TTATGATTAT TATTAGTGAC ATATTGACAA TCATTGGATC AATTCTAAAA ATGGAAATCC 1140
AAGCTAAGAG TCTAACTAGT TATGATGTCT GTAGCATACT TCTTGGGACT TCTACCATGC 1200
TCGTGTGGCT TGGAGTCATC CGATACCTCG GTTTCTTTGC AAAGTACAAC CTCCTCATTT 1260
TGACCCTTCA GGCAGCGCTG CCCAATGTCA TCAGGTTCTG CTGCTGTGCA GCTATGATTT 1320
ACTTAGGTTA CTGCTTCTGT GGATGGATCG TGCTGGGGCC TTACCATGAC AAGTTTCGTT 1380
CTCTGAACAT GGTCTCTGAG TGCCTTTTCT CTCTGATAAA TGGAGATGAT ATGTTTGCCA 1440
CGTTTGCAAA AATGCAGCAA AAAAGTTACT TAGTCTGGCT GTTTAGTAGA ATTTACCTCT 1500
ACTCATTCAT CAGCCTCTTT ATATATATGA TTTTAAGTCT TTTCATTGCA CTGATCACTG 1560
ATACATACGA AACAATTAAG CAATACCAAC AAGATGGCTT CCCAGAGACT GAACTTCGTA 1620
CATTTATATC AGAATGCAAA GATCTACCCA ACTCTGGAAA ATACAGATTA GAAGATGACC 1680
CTCCAGTATC TTTATTCTGC TGTTGTAAAA AGTAGCTATC AGGTTTATCT GTACTTTAGA 1740
GGAAAATATA ATGTGTAGCT GAGTTGGAAC ACTGTGGATA TTCTGAGATC AGATGTAGTA 1800
TGTTTGGAGA CTGTTATTTT GAGCTAATTG AGACCTATAA TTCACCAATA ACTGTTTATA 1860
TTTTTAAAAG CAATATTTAA TGTCTTTGCA ACTTTATGCT 1900
Seq ID NO 187 DNA Sequence
Nucleic Acid Access ion tt NM_000114 1
Coding sequence 194 910
1 11 21 31 41 51
I I I I I I
CGGGTAGCGC GCTCTGAAAG TTTATGACCG CCGCAGCCAA CTCCTGGCCG GAGCTGGAGA 60
CGCAGCGAGC GATCGGCCGG CCTCGAACCC CCACAGCTGC AGGGCGAGGC CAGCTGTACC 120
CGGCCCCAGT GCCCTTTCGC GGCCACAAGC GGCCGTCCTC CTCCTCCGGT GCTCCGCCGC 180
CTGATCTAGG TTCATGGAGC CGGGGCTGTG GCTCCTTTTC GGGCTCACAG TGACCTCCGC 240
CGCAGGATTC GTGCCTTGCT CCCAGTCTGG GGATGCTGGC AGGCGCGGCG TGTCCCAGGC 300
CCCCACTGCA GCCAGATCTG AGGGGGACTG TGAAGAGACT GTGGCTGGCC CTGGCGAGGA 360
GACTGTGGCT GGCCCTGGCG AGGGGACTGT GGCCCCGACA GCACTGCAGG GTCCAAGCCC 420
TGGAAGCCCT GGGCAGGAGC AGGCGGCCGA CCGGGCCCCT GAGCACCACC GATCCAGGCG 480
CTGCACGTGC TTCACCTACA AGGACAACCA GTGTGTCTAC TATTGCCACC TGGACATCAT 540
TTGGATCAAC ACTCCCGAAC AGACGGTGCC CTATGGACTG TCCAACTACA GAGGAAGCTT 600
CCGGGGCAAG AGGTCTGCGG GGCCACTTCC AGGGAATCTG CAGCTCTCAC ATCGGCCACA 660
CTTGCGCTGC GCTTGTGTGG GGAGATATGA CAAGGCCTGC CTGCACTTTT GCACCCAAAC 720
TCTGGACGTC AGCAGTAATT CAAGGACCCC AGAAAAAACA GACAAAGAAG AGGAAGGGAA 780
GGTTGAAGTC AAGGACCAAC AAAGCAAGCA GGCTTTAGAC CTCCACCATC CAAAGCTCAT 840
GCCCGGCAGT GGACTCGCCC TCGCTCCATC TACCTGCCCC CGCTGCCTCT TTCACCAAGG 900
AGCCCCTTAG GAGGACAGGC CTGCAGCTCC AATTTCATGC AGGAAATTGG TTTTGGAGAG 960
TTTTGGCAAG TTGGAAAGCC ACTTACTGGC TTTTGACATG ACTTCTCTTG GAGAATAAGT 1020
GGACTCCAAG CTAACTCTTT GCAAATGTAA ACACATGTCC ATCTTGTTAA TAAATGCAAA 1080
ATGCCCGTGC AGCAGAAGCA TGCGACTTTC ATATCCTTGC CTAGAA AGG CTGCATGGTG 1140
TATGTCAGTG AGGGCCACGA GGCGTCGGCT TTAGACACAG ATCATAGCTC TACAGCAGTT 1200
TATGAATTTG AAGCTTATGG GATTTTGGCA GAGAAATTTT CAGCTGTGCT TGATACCCAC 1260
CAAAAGAATG TATCTCGAAA GAATGAAGGA AGAAGAAAAA AGGATCCTTG ATGTTTGTGA 1320
CAAGAAAATG AGAAAGTTAG TATCTGCAAT ACAGAGCTTG TTCCTGTTCA GTGACTGACC 1380 CTCTGTATTC TGTATAGACA CCAGGCCGAT ACACAGTGCA GTTCCCAGCC CTTGTTTGCA 1440
GGAAGCCGAC TGTAAAGACA GCCCCAGCTC AAGGCTATTA GGTTGAATAT TTGCTTTCAT 1500
GAGTAAATGT GGATCTTTGG GGAATGGCTT CAAAATAAGT CACGAACACA AATTCTTTGT 1560
AAATTATGTA AATTCCTGTT TATATAAATT GGCAACAACT TATACCGTCT GACAGTTCAA 1620 AATCTCTTTC AGCTGCGCTC TTCCCACCGA GCCGAGCTTA CTGTGAGTGT GGAGATGTTA 1680
TCCCACCATG TAAAGTCGCC TGCGCAGGGG AGGGCTGCCC ATCTCCCCAA CCCAGTCACA 1740
GAGAGATAGG AAACGGCATT TGAGTGGGTG TCCAGGGCCC CGTAGAGAGA CATTTAAGAT 1800
GGTGTATGAC AGAGCATTGG CCTTGACCAA ATGTTAAATC CTCTGTGTGT ATTTCATAAG 1860
TTATTACAGG TATAAAAGTG ATGACCTATC ATGAGGAAAT GAAAGTGGCT GATTTGCTGG 1920 TAGGATTTTG TACAGTTTAG AGAAGCGATT ATTTATTGTG AAACTGTTCT CCACTCCAAC 1980
TCCTTTATGT GGATCTGTTC AAAGTAGTCA CTGTATATAC GTATAGAGAG GTAGATAGGT 2040
AGGTAGATTT TAAATTGCAT TCTGAATACA AACTCATACT CCTTAGAGCT TGAATTACAT 2100
TTTTAAAATG CATATGTGCT GTTTGGCACC GTGGCAAGAT GGTATCAGAG AGAAACCCAT 2160
CAATTGCTCA AATACTCAGA AAGTACTGTC AAAAGCCTAA TAAAAAACCT AAAGTTTGCT 2220
CTG 2223
Seq ID NO 188 DNA Sequence
Nucleic Acid Accession It NM_005356 2
Coding sequence 52 1581
1 11 21 31 41 51
I I I I I I
CGCCTGGACC ATGTGAATGG GGCCAGAGGG CTCCCGGGCT GGGCACCGAC CATGGGCTGT 60
GGCTGCAGCT CACACCCGGA AGATGACTGG ATGGAAAACA TCGATGTGTG TGAGAACTGC 120
CATTATCCCA TAGTCCCACT GGATGGCAAG GGCACGCTGC TCATCCGAAA TGGCTCTGAG 180
GTGCGGGACC CACTGGTTAC CTACGAAGGC TCCAATCCGC CGGCTTCCCC ACTGCAAGAC 240
AACCTGGTTA TCGCTCTGCA CAGCTATGAG CCCTCTCACG ACGGAGATCT GGGCTTTGAG 300
AAGGGGGAAC CACTCCGCAT CCTGGAGCAG AGCGGCGAGT GGTGGAAGGC GCAGTCCCTG 360
ACCACGCGCC AGGAAGGCTT CATCCCCTTC AATTTTGTGG CCAAAGCGAA CAGCCTGGAG 420
CCCGAACCCT GGTTCTTCAA GAACCTGAGC CGCAAGGACG CGGAGCGGCA GCTCCTGGCG 480
CCCGGGAACA CTCACGGCTC CTTCCTCATC CGGGAGAGCG AGAGCACCGC CGGGTCCTTT 540
TCACTGTCGG TCCGGGACTT CGACCAAAAC CAGGGAGAGG TGGTGAAACA TTACAAGATC 600
CGTAATCTGG ACAACGGTGG CTTCTACATC TCCCCTCGAA TCACTTTTCC CGCCCTGCAT 660
GAACTGGTCC GCCATTACAC CAATGCTTCA GATGGGCTGT GCACACGGTT GAGCCGCCCC 720
TGCCAGACCC AGAAGCCCCA GAAGCCGTGG TGGGAGGACG AGTGGGAGGT TCCCAGGGAG 780
ACGCTGAAGC TGGTGGAGCG GCTGGGGGCT GGACAGTTCG GGGAGGTGTG GATGGGGTAC 840
TACAACGGGC ACACGAAGGT GGCGCTGAAG AGCCTGAAGC AGGGCAGCAT GTCCCCGGAC 900
GCCTTCCTGG CCGAGGCCAA CCTCATGAAG CAGCTGCAAC ACCAGCGGCT GGTTCGGCTC 960
TACGCTGTGG TCACCCAGGA GCCCATCTAC ATCATCACTG AATACATGGA GAATGGGAGT 1020
CTAGTGGATT TTCTCAAGAC CCCTTCAGGC ATCAAGTTGA CCATCAACAA ACTCCTGGAC 1080
ATGCCAGCCC AAATTGCAGA AGGCATGGCA TTCATTGAAG AGCGGAATTA TATTCATCGT 1140
GACCTTCGGG CTGCCAACAT TCTCCTGTCT GACACCCTGA GCTGCAAGAT TGCAGACTTT 1200
GGCCTAGCAC GCCTCATTGA GGACAACGAG TACACAGCCA GGGAGGGGGC CAAGTTTCCC 1260
ATTAAGTGGA CAGCGCCAGA AGCCATTAAC TACGGGACAT TCACCATCAA GTCAGATGTG 1320
TGGTCTTTTG GGATCCTGCT GACGGAAATT GTCACCCACG GCCGCATCCC TTACCCAGGG 1380
ATGACCAACC CGGAGGTGAT TCAGAACCTG GAGCGAGGCT ACCGCATGGT GCGCCCTGAC 1440
AACTGTCCAG AGGAGCTGTA CCAACTCATG AGGCTGTGCT GGAAGGAGCG CCCAGAGGAC 1500
CGGCCCACCT TTGACTACCT GCGCAGTGTG CTGGAGGACT TCTTCACCCC CACAGAGGGC 1560
CAGTACCAGC CTCAGCCTTG AGAGGAGGCC TTGAGAGGCC CTGGGGTTCT CCCCCTTTCT 1620
CTCCAGCCTG ACTTGCGGAG ATGGAGTTCT TGTGCCATAG TCACATGGCC TATGCACATA 1680
TGGACTCTGC ACATGAATCC CACCCACATG TGACACATAT GCACCTTGTG TCTGTACACG 1740
TGTCCTGTAG TTGCGTGGAC TCTGCACATG TCTTGTGCAT GTGTAGCCTG TGCATGT TG 1800
TCTTCCACAC TGTACAAGGT ACCCCTTTCT GGCTCTCCCA TTTCCTGAGA CCACCAGAGA 1860
GAGGGGAGAA GCCTGGGATT GACAGAAGCT TCTGCCCACC TACTTTTCTT TCCTCAGATC 1920
ATCCAGAAGT TCCTCAAGGG CCAGGACTTT ATCTAATACC TCTGTGTGCT CCTCCTTGGT 1980
GCCTGCCCTG GCACACATCA GGAGTTCAAT AAATGTCTGT TGATGACTGC CG 2032
Seq ID NO 189 DNA Sequence
Nucleic Acid Accession tt NM_0146S4 1
Coding sequence 1504 2658
1 11 21 31 41 51
I I I I I I
CTGAGATGCA GGCCCAGCGC TGGCGCAGTG AGAACTTCGA GAGACCCGTG GACCTGGAGG 60
GCTCTGGGGA TGATGACTCC TTTCCCGATG ATGAACTGGA TGACCTCTAC TCGGGGTCGG 120
GCTCGGGCTG TAAGTACCCC CCTCCCTACC TCTGCCTGGG GGCAGTGACC AGTCTGTATC 180
CAGCCTCAAC TCTGAGAAGC CCACGGGGGG CTTGCTTCAG TGAGGCAGGG GGCATTCACT 240
GCCTGGGTCA GGCAAGTTCT TCTTGCTCTG GATCCCCAGA ACAAGAAGGG CAGAACATCC 300
TTCTGGGGAT AGAACAAGAC CTGGGAGGAC CTCAGGGCCC AGAATGTCCA GGTCTCCAGG 360
GTCCCACGTC TGCATCTTTG TGTGTGCTAT GTGGCTTTCT CTGCAGACCT TGCTTGGTTC 420
CGGTGGTCCC GTCAGGTGCA ATAAGCTGTG GCCAATGGTG GGGTTAGGGC AGTGATGACA 480
CAGGGCAGCT GCTTCAAGTG GTGCCTGGGA TGGCCCCGCC CTCCGGAAGG GGAGCCAGGT 540
CAGCTGGGTC TAGCAGAATC TCGCGAGAGA AGGGCACCGC GAACCCCACT CTGCCATGTA 600
GCAACTGTGT GCCCCTCGGT GCTCCCCCTC CCTGAATCCC TGTATTTTCA CCTGTGGATG 660
GTGAGAAATA CGACTTCTTC TCAGTGCCTC TAGGAGGGTT TGGGATAGGA AGCTGGGGTC 720
TGGCACAGAG GAGGAGCTCT CAAAATGGTA GCAAAAAGAA GGCAGCTGAG ACTGGGCCCA 780
GTGAGGGCAC GGGCTGGCAT CTGAGGAGAT GGTACGGGGT CTGCACGCCA CAGAGCTGGC 840 TCCCCACAGC CCTCGCCTCT GGTCTCCCCT CCTTAGCCAA GTCCTTTGAG CCTCTTTCAA 900 ATTAATCTTT GTAAAACCCG TTTATATTGG GTCACATCTC TATTCGCAAA GTTCCCTGGC 960 TCCCCTCCCT CCTGCCTGGT TCCGAGCCCA GGAGCTGGCT GTGGCTTCTC CCTCCCCCAT 1020 CCCCTACTCC CCGTCTCATT TCCTCCCAAG TTCCTTCACT GTCCCGGCTT TGCGTCAGCC 1080 AGATTGCTCA AGCAGTTCCC CTGCCTCAAG GGCTTCTTTT CCCTTTTACC CTCCGCCTCT 1140 GCCTCTGGGG GAAGCCCTTA GTGTACCACC CCTGCCTTGA GCTTGTGGTA GGGGTGCCTT 1200 TGGGGTCTGA CTCTTCCCAG AATGCCACTC CTGTGTTCCC CTGCAAGCCC CAGCAAGTTT 1260 TGCAGCCAGT AGCGCCTCAG TTGCTGCTGC CTGGATTCAA CCTCATAGAA ACTGTAGGCT 1320 GGGTGGGCAG GAATAGTCAA GGAAGGCTTC CCGGGAGAGG CGGCCCCCAG AATTTTTGAC 1380 TTGGCAGAGA GAAGTTGGGG AACATCAGCA ACTGACCACC TTTAGCTGGC TGTGCCTTCC 1440
TCCTTTCTCT CATCTTTTCT GGGAAAATTG GGTAAAGAGA GGGGGTTGGG AGACCTAATC 1500
TTGATGGCCA TTGCTTACCT GGGATCCTCA TGCCCCTCAC AACCACCCAG CTCCCTAGCT 1560
CTCTCCCTCT CCCCCACCCC CTCAGACTTC GAGCAGGAGT CGCGCATTGA GACAGCCATG 1620
CGCTTCAGCC CAGATGTAGC CCTGGCGGTG TCCACCACAC CTGCGGTGCT GCCCACCACG 1680
AACATCCAGC CTGTGGGCAC ACCATTTGAA GAGCTCCCCT CTGAGCGCCC CACCCTGGAG 1740
CCAGCCACCA GCCCCCTGGT GGTGACAGAA GTCCCGGAAG AGCCCAGCCA GAGAGCCACC 1800
ACCGTCTCCA CTACCATCCC TACCACTGCT GCCACAAGCA CAGGGGACCC GACTGTGGCC 1860
ACAGTGCCTG CCACAGTGGC CACCGCCACC CCCAGCACCC CTGCAGCACC CCCTTTTACG 1920
GCCACCACTG CTGTTATAAG GACCACTGGC GTACGGAGGC TTCTGCCTCT CCCACTGACC 1980
ACAGTGGCTA CGGCACGGGC CACTACCCCC GAGGCGCCCT CCCCGCCCAC CACGCCGGCT 2040
GTCTTGGACA CCGAGGCCCC AACACCCAGG CTCCTCAGCA CAGCTACCTC CCGCCCAAGA 2100
GCCCTTCCCA GGCCGGCCAC CACCCAGGAG CCTGACATCC CTGAGAGGAG CACCCTGCCC 2160
CTGGGGACCA CTGCCCCTGG ACCCACAGAG GTGGCTCAGA CCCCAACTCC AGAGACCTTC 2220
CTGACCACAA TCCGGGATGA GCCAGAGGTT CCGGTGAGTG GGGGGCCCAG TGGAGACTTC 2280
GAGCTGCCAG AAGAAGAGAC CACACAACCA GACACAGCCA ATGAGGTGGT AGCTGTGGGA 2340
GGGGCTGCGG CCAAGGCATC ATCTCCACCT GGGACACTGC CCAAGGGTGC CCGCCCGGGC 2400
CCTCCCCTCC TGGACAATGC CATCGACTCG GGCAGCTCAG CTGCTCAGCT GCCTCAGAAG 2460
AGTATCCTCC AGCGGAAGGA GGTGCTCGTA GCTGTGATTG TGGGCGGGGT GGTGGGCGCC 2520
CTCTTTGCTG CCTTCTTGGT CACACTGCTC ATCTATCGTA TGAAGAAAAA GGATGAGGGC 2580
AGCTACACGC TGGAGGAACC CAAGCAGGCG AGCGTCACAT ACCAGAAGCC TGACAAGCAG 2640
GAGGAGTTCT ATGCCTAGTG GAGCCACAGT GCCTCCCTGC AGCCTCAACA CCACCCTGCT 2700
GTCCAGTCCC CAGCCTGGCC CCACCAGCCC AAGCCTGGGA CTGGGCCTGG AACCTGGCCC 2760
CAGTTCTTCT CTGCCCTCTC TCCCAAGGTC TGCCCAGCCT GCCAGCCTCA CACAGATCTT 2820
CCCCGAGGAA GAGGGGCTGC TGCCATCTGC CCCAGACTGT GCCCTTACGA GCTCATCTCT 2880
TGTTCCCCTC ATCCCTGCCA CCAGTCTGGG GCTTCAGGAC CTCATGTCAG ATGGATGGGA 2940
GGAAGAAAGC TCCTGATTGG CTGGTGGTGG AAGAAAGGGT GGGGCTTGAG ATGAGCCTGA 3000
GCCCTGACTT GGCACCCACA GTGCTCACTG AGATCTCCTT TTTGGGGCAG AGAGGCACTC 3060
AGGCTGGTTT CCAGCACAAA CATTTCCTAA ACACAGCCCT TGAAATCATC TAGACACTGC 3120
AACCTCTTGC TCGTATCCCA GGGCCTCTCT CTAGCTGGGT GAGAGGGTGT CCCTTGTCAC 3180
CAGCCTGTTT TGTCCTGGTC TCTCTCCGGT TGTTGAATCT CTCCTCTTGC CTGCCAAGTA 3240
CACATGTACC CAGACTTCAT TTCTTTCTGC ATCTTCCCCC AAGAAACAGC TTCCTGAGCG 3300
TGCTGGGGCA GCCACTGGTG AGGAGGGGCT GCTCTGATGT CCCTCCTATG AGGGGACTCT 3360
GCACAGACAC CATTGCCCAC ACTATCACCA TATTTTCACT CAGTCACACA CAAGACAAAA 3420
GCATGCAATG ACAAAACCAT ACGCAATCCT GACCGCCCAG CCAATCAAGA CATATCACAG 3480
AACACACGCG TCCTTCCAAG AATGTTTATC CTCATGCATC ACTTACACAC CCCCAGACAC 3540
GTACTGCAAT GCAAGTCACT AGTCATGGTC ACATGACAGT GACAGTGTGG CCTCCTCCTA 3600
CCCCAAATAC ACCCACACTC TGGCACCACA CACATTGTCT CCAGCTTTCA GGCTTACTGG 3660
GGAGGGTGGA ATCGAGCCAG AACAATCAGC CCATATTGGC TCCCCCTAAG TTGCCCCGTC 3720
ATACTCAGTC CCATGCCATG GTGCCCACAC CAACCATGCA GCCACCAACC CCAGCCAGTG 3780
TCAGACACAA TCCCATGTGG ATGCACAGTC TCACTCCACA TGACCTGCTC TCAATGCTGG 3840
AGGGAAACAG GCAGCCCCTT GCCTTTCTCG GAAAAAGTGT GGGGCCACAG CCCTTTTAGG 3900
GCATTGCATG CAGGTGGGCC TGGCTTCACC CCTACCTGCT TCCTCCCCAC CGCAGCTGGC 3960
AGAGGGGGAG GTTTGGGGCC AGACCCCCAC TAGCTCCGAG CCTGCGGGCT CCTCTAAGGC 4020
TGAGGAAGGA AATTTGGCCC CAGGTTGTTG GGGGGTCTTG GGTCTCCCAG GACGGAAGGC 4080
CCAGGCCAGG GAGGGGGCAT GTGGTTGGGC TCCTTTATCT CCCTGTGTCC CCTTCCTGCT 4140
TTGAGCTAGG GGGCTGACTC TGCCTCCCAG GACACAAGTC TCCAAAGTGC CTGTGAGGGC 4200
GGGCCCTCCG CACCCTCTGC CCTCTGCCTG GCAGGCCAAC CTCAGCCCAC CTGCCCAGAG 4260
GCCCTCCCTG TGGACACCCC CTCACCTATT TGGCCAAACA ATTCTGGCTG CAGCTTCAGG 4320
GGCCATGGCT GGAAGCAGCC CCTGCAGATC CCTCAGGCCC CGAGGTCAGG GTTTGAGGGA 4380
TGAGACCAGG TGATAGTGGG GGAGGGGTTA CTTCCTTTGT TACCTAGCAA GTAGGGCTAT 4440
TTCCATCGGT ATTTTAAATG TGGGGTCACA GATCTTTTGG GGAGGGTGTG CTTGCCACCG 4500
GGCCTCTTGG AGCCAAAGGG ATGTGGTGTG AGTTGCGATT GGCTGCCACT CACACCCCCA 4560
CCCCTCACCC ACATCCCAGA TTCAAGTCAG GAAGGCAGGT TTTATTTCAG GGCCCTTTTC 4620
AAGATGCCCT GGCAGCAGAT TTCTGCAGGA TGAGGGGTAG CGGTGTGTAG GCAGTGAGGG 4680
GGAGGTTCCA GGGGCTGTCC CACAGCCTGT CTTTTCCAGG CTGCGCTCCA TCTTCCAGTC 4740
CCAAAACCCT CCTTCACAGG GCCCAGAGGC TTGTGAGGAA GCCAGGTGGA CCCAGCCTTG 4800
GAAGAGTGGG CATGGGGGGC CCCTGATATC TGCAGGGGGC GGGTTGGCCT CAGTCATCTT 4860
TGGAGCAGAA GGGCTGGGTC CTGGGGCCAC AGACCACAAG GCTCAGCCTC CCTACCCTGC 4920
TCCCTGGGGT GCTGCTGTCT TGGAGAGCAC AGCTCTGGTG AGACGGCCTG GGCACCCCGA 4980
GCCTGAGAAA CCAGGGAGGA TAGAGGAGAA AAGGGCTTGG GCCCCCAGCC CCAGAAGATG 5040
CTGCGCCCCA GGTGGGAGAC CCAACAGTGG GTGCAGTTTC TCAGTGGGGC TGGAGCCAAT 5100
GGTGGGGGTG GCCCCGGCAG GCCTGGCTCC TCACATCCCA GGGGTTGGCT TCTGATTTGG 5160
GGCTTGGGCT CCAGGCACTG GCTTCTCTTC TCTGTGTCCT TAGCATTTGA GAGAAGAGGC 5220
CAGGGGCCTT GTTCATGGAT CCCTCCACCC AAGGCAGATG TCCAGGCTTT ATCCTCCTGA 5280
GGATGAGGAG TCTGACCAGC CCAAATCTGC CCTGGCCGGC CTGACCGGGG CAAGGCAGTC S340
CAAGAGAGTT CAGTGAGGAC CAGCTAGGCT CTCCCAGGTG CAATGTGGGT GCAGGGCCCT 5400
CATGTCCCCC TACCCCTGCC TGTGATGGAG TGTTCTGAGG GGCTTTGGCA TTTGCTCCAA 5460
GCACAGCGAG TTCCAAATGA GAGGGAGCTT CTGTGGCTTG AGAGCCTCTG GGGCCTTCCC 5520
TGCCAGAGCA CGAGGCAGGC CAGGACCTGG AGAGCCCAGA CCCTGTCTCC AGGAGGCCAG 5580
GAGGCCAGAT GGGGGCCTTG CCTGAAAGAC TGGTCCCCTT GATCGCTGGA GGCATGTGGG 5640
TGGCAACCAG GGCTCCGCAG GGCTTAGGGT GTGTGGGCCA AACCCCCCTG GGGTTGGCAA 5700
AGCCGCCTGT CAGGCCTCCT GCTGGGGGCC CCTGGACACA GGGAGCAGAC CCTCTGCCTC 5760
ATGGGGTAGG AGTGGCTGCC TCCTGTGTTC TCTGGATTTC TTCTCCCAAC AACTACAACC 5820
CTGCACTTGC CTCCCCAGGC CTCTTGCCTG TAAATAGAAG CCCGCAAACT GTACAGATTT 5880
ACAGAGGCAT CGAGACTGGG CCCTGGGAGT TGCCATCTGA GAGCCGATCC CCCCAGCATC 5940
CCCCACCTGC CTGCCTCCCA CCACAGTGAC CCTGCCCTCA GCGTGGCAAA TGCATGTAAA 6000
TATTTTTCGT AGGCAGCGTG GCTCCAGAGA GCCCCCTGAA GACAGTGTCC CTCCCTCCTG 6060
TGAGTCCTTT CTCCTGTACA GAACCTGCCT GGGGTGGGTG GGGGTCTGCC ATTCCCTCCC 6120
CCAGGCCTTC CCTGCCCCTT CTCTCCCCTG TAACCTGTTT ATTAACCATA CCTGTCCTGA 6180
GTTCATGGCC AAAACCTTAA ATAAGAAAAA CAAAAGAAAA AGACAGTGGA AAAAAGAGAC 6240
CAAGGCGCCT GCCCCACTGC GGGTACTCTC CTGTTCCAGC CTTGTGAAGG AACTGGTTTT 6300
GTTTTTGTTT TTGTTTTTTT TTTTTTTGTT TGTTTGTTTG TTTTTTAACA CTTCCTGTGC 6360
TGTGCCCATT TATAAGAGGA AATAAAATTA AGCTGAAATG 6400 Seq ID NO 190 DNA Sequence Nucleic Acid Accession NM_00691 2 Coding sequence 189 1580 1 11 21 31 41 51
I I I I I I
CTCCGATCTA GAGGCAGATT CCTGACTAAT CCCAGAGGGC TGGCCCAGCC TGTGCTCCCC 60
GGGCTGCTAG GAAGCGATGA CCACTCTTGT TAGCCCAAGT TGAAGAAAGC CGGGCTGTGC 120
CTCCGAGCCG AGAGAGGCGG TAATATTTAG AAGCTGCACA GGAGAGGAAC ATGAACTGAC 180 GAGTAAACAT GTATGGAAAT TATTCTCACT TCATGAAGTT TCCCGCAGGC TATGGAGGCT 240
CCCCTGGCCA CACTGGCTCT ACATCCATGA GCCCATCAGC AGCCTTGTCC ACAGGGAAGC 300
CAATGGACAG CCACCCCAGC TACACAGATA CCCCAGTGAG TGCCCCACGG ACTCTGAGTG 360
CAGTGGGGAC CCCCCTCAAT GCCCTGGGCT CTCCATATCG AGTCATCACC TCTGCCATGG 420
GCCCACCCTC AGGAGCACTT GCAGCGCCTC CAGGAATCAA CTTGGTTGCC CCACCCAGCT 480 CTCAGCTAAA TGTGGTCAAC AGTGTCAGCA GTTCAGAGGA CATCAAGCCC TTACCAGGGC 540
TTCCCGGGAT TGGAAACATG AACTACCCAT CCACCAGCCC CGGATCTCTG GTTAAACACA 600
TCTGTGCCAT CTGTG AGAC AGATCCTCAG GAAAGCACTA CGGGGTATAC AGTTGTGAAG 660
GCTGCAAAGG GTTCTTCAAG AGGACGATAA GGAAGGACCT CATCTACACG TGTCGGGATA 720
ATAAAGACTG CCTCATTGAC AAGCGTCAGC GCAACCGCTG CCAGTACTGT CGCTATCAGA 780 AGTGCCTTGT CATCCGCATG AAGAGGGAAG CTGTGCAAGA AGAAAGACAG AGGAGCCGAG 840
AGCGAGCTGA GAGTGAGGCA GAATGTGCTA CCAGTGGTCA TGAAGACATG CCTGTGGAGA 900
GGATTCTAGA AGCTGAACTT GCTGTTGAAC CAAAGACAGA ATCCTATGGT GACATGAATA 960
TGGAGAACTC GACAAATGAC CCTGTTACCA ACATATGTCA TGCTGCTGAC AAGCAGCTTT 1020
TCACCCTCGT TGAATGGGCC AAGCGTATTC CCCACTTCTC TGACCTCACC TTGGAGGACC 1080 AGGTCATTTT GCTTCGGGCA GGGTGGAATG AATTGCTGAT TGCCTCTTTC TCCCACCGCT 1140
CAGTTTCCGT GCAGGATGGC ATCCTTCTGG CCACG GTTT ACATGTCCAC CGGAGCAGTG 1200
CCCACAGTGC TGGGGTCGGC TCCATCTTTG ACAGAGTCCT AACTGAGCTG GTTTCCAAAA 1260
TGAAAGACAT GCAGATGGAC AAGTCGGAAC TGGGATGCCT GCGAGCCATT GTACTCTTTA 1320
ACCCAGATGC CAAGGGCCTG TCCAACCCCT CTGAGGTGGA GACTCTGCGA GAGAAG TTT 1380 ATGCCACCCT TGAGGCCTAC ACCAAGCAGA AGTATCCGGA ACAGCCAGGC AGGTTTGCCA 1440
AGCTGCTGCT GCGCCTCCCA GCTCTGCGTT CCATTGGCTT GAAATGCCTG GAGCACCTCT 1S00
TCTTCTTCAA GCTCATCGCG GACACCCCCA TTGACACCTT CCTCATGGAG ATGTTGGAGA 1560
CCCCGCTGCA GATCACCTGA GCCCCACCAG CCACAGCCTC CCCACCCAGG ATGACCCCTG 1620
GGCAGGTGTG TGTGGACCCC CACCCTGCAC TTTCCTCCAC CTCCCACCCT GACCCCCTTC 1680 CTGTCCCCAA AATGTGATGC TTATAATAAA GAAAACCTTT CTACAAAAAA AAAAAAAAAA 1740
AA 1742
Seq ID NO 191 DNA Sequence
Nucleic Acid Accession NM_002185 1
Coding sequence 23 1402
1 11 21 31 41 51
I I I I I I
CTCTCTCTCT ATCTCTCTCA GAATGACAAT TCTAGGTACA ACTTTTGGCA TGGTTTTTTC 60
TTTACTTCAA GTCGTTTCTG GAGAAAGTGG CTATGCTCAA AATGGAGACT TGGAAGATGC 120
AGAACTGGAT GACTACTCAT TCTCATGCTA TAGCCAGTTG GAAGTGAATG GATCGCAGCA 180
TTCACTGACC TGTGCTTTTG AGGACCCAGA TGTCAACACC ACCAATCTGG AATTTGAAAT 240
ATGTGGGGCC CTCGTCCAGG TAAAGTGCCT GAATTTCAGG AAACTACAAG AGATATATTT 300
CATCGAGACA AAGAAATTCT TACTGATTGG AAAGAGCAAT ATATGTGTGA AGGTTGGAGA 360
AAAGAGTCTA ACCTGCAAAA AAATAGACCT AACCACTATA GTTAAACCTG AGGCTCCTTT 420
TGACCTGAGT GTCATCTATC GGGAAGGAGC CAATGACTTT GTGGTGACAT TTAATACATC 480
ACACTTGCAA AAGAAGTATG TAAAAGTTTT AATGCATGAT GTAGCTTACC GCCAGGAAAA S40
GGATGAAAAC AAATGGACGC ATGTGAATTT ATCCAGCACA AAGCTGACAC TCCTGCAGAG 600
AAAGCTCCAA CCGGCAGCAA TGTATGAGAT TAAAGTTCGA TCCATCCCTG ATCACTATTT 660
TAAAGGCTTC TGGAGTGAAT GGAGTCCAAG TTATTACTTC AGAACTCCAG AGATCAATAA 720
TAGCTCAGGG GAGATCCATC CTATCTTACT AACCATCAGC ATTTTGAGTT TTTTCTCTGT 780
CGCTCTGTTG GTCATCTTGG CCTGTGTGTT ATGGAAAAAA AGGATTAAGC CTATCGTATG 840
GCCCAGTCTC CCCGATCATA AGAAGACTCT GGAACATCTT TGTAAGAAAC CAAGAAAAAA 900
TTTAAATGTG AGTTTCAATC CTGAAAGTTT CCTGGACTGC CAGATTCATA GGGTGGATGA 960
CATTCAAGCT AGAGATGAAG TGGAAGGTTT TCTGCAAGAT ACGTTTCCTC AGCAACTAGA 1020
AGAATCTGAG AAGCAGAGGC TTGGAGGGGA TGTGCAGAGC CCCAACTGCC CATCTGAGGA 1080
TGTAGTCGTC ACTCCAGAAA GCTTTGGAAG AGATTCATCC CTCACATGCC TGGCTGCGAA 1140
TGTCAGTGCA TGTGACGCCC CTATTCTCTC CTCTTCCAGG TCCCTAGACT GCAGGGAGAG 1200
TGGCAAGAAT GGGCCTCATG TGTACCAGGA CCTCCTGCTT AGCCTTGGGA CTACAAACAG 1260
CACGCTGCCC CCTCCATTTT CTCTCCAATC TGGAATCCTG ACATTGAACC CAGTTGCTCA 1320
GGGTCAGCCC ATTCTTACTT CCCTGGGATC AAATCAAGAA GAAGCATATG TCACCATGTC 1380
CAGCTTCTAC CAAAACCAGT GAAGTGTAAG AAACCCAGAC TGAACTTACC GTGAGCGACA 1440
AAGATGATTT AAAAGGGAAG TCTAGAGTTC CTAGTCTCCC TCACAGCACA GAGAAGACAA 1500
AATTAGCAAA ACCCCACTAC ACAGTCTGCA AGATTCTGAA ACATTGCTTT GACCACTCTT 1560
CCTGAGTTCA GTGGCACTCA ACATGAGTCA AGAGCATCCT GCTTCTACCA TGTGGATTTG 1620
GTCACAAGGT TTAAGGTGAC CCAATGATTC AGCTATTT 1658
Seq ID NO 192 DNA Sequence
Nucleic Acid Accession It NM_006272 1
Coding sequence 73 351
1 11 21 31 41 51
I I I I I I
TGCCGCCCAG GACCCGCAGC AGAGACGACG CCTGCAGCAA GGAGACCAGG AAGGGGTGAG 60
ACAAGGAAGA GGATGTCTGA GCTGGAGAAG GCCATGGTGG CCCTCATCGA CGTTTTCCAC 120
CAATATTCTG GAAGGGAGGG AGACAAGCAC AAGCTGAAGA AATCCGAACT CAAG AGCTC 180
ATCAACAATG AGCTTTCCCA TTTCTTAGAG GAAATCAAAG AGCAGGAGGT TGTGGACAAA 240
GTCATGGAAA CACTGGACAA TGATGGAGAC GGCGAATGTG ACTTCCAGGA ATTCATGGCC 300
TTTGTTGCCA TGGTTACTAC TGCCTGCCAC GAGTTCTTTG AACATGAGTG AGATTAGAAA 360
GCAGCCAAAC CTTTCCTGTA ACAGAGACGG TCATGCAAGA AAGCAGACAG CAAGGGCTTG 420
CAGCCTAGTA GGAGCTGAGC TTTCCAGCCG TGTTGTAGCT AATTAGGAAG CTTGATTTGC 480 TTTGTGATTG AAAAATTGAA AACCTCTTTC CAAAGGCTGT TTTAACGGCC TGCATCATTC S40
TTTCTGCTAT ATTAGGCCTG TGTGTAAGCT GACTG CCCC AGGGACTCTT GTTAACAGTA 600
ACTTAGGAGT CAGGTCTCAG TGATAAAGCG TGCACCGTGC AGCCCGCCAT GGCCGTGTAG 660
ACCCTAACCC GGAGGGAACC CTGACTACAG AAATTACCCC GGGGCACCCT TAAAACTTCC 720 ACTACCTTTA AAAAACAAAG CCTTATCCAG CATTATTTGA AAACACTGCT GTTCTTTAAA 780
TGCGTTCCTC ATCCATGCAG ATAACAGCTG GTTGGCCGGT GTGGCCCTGC AAGGGCGTGG 840
TGGCTTCGGC CTGCTTCCCG GGATGCGCCT GATCACCACC TGAACGCTCA GCGCTGGCAG 900
CGTCCTGGAA AAAGCAACTC CATCAGAACT CGCAATCCGA GCCAGCTCTG GGGGCTCCAG 960
CGTGGCCTCC GTGACCCATG CGATTCAAGT CGCGGCTGCA GGATCCTTGC CTCCAACGTG 1020 CCTCCAGCAC ATGCGGCTTC CGAGGGCACT ACCCCGGGCT CTGAGCCACC GCGAGGGCCT 1080
GCGTTCAATA AAAAG 1095
Seq ID NO 193 DNA Sequence Nucleic Acid Accession tt NM_006157 1 Coding sequence 103 2535
1 11 21 31 41 51
I I I I I I
TAGCAAGTTT GGCGGCTCCA AGCCAGGCGC GCCTCAGGAT CCAGGCTCAT TTGCTTCCAC 60
CTAGCTTCGG TGCCCCCTGC TAGGCGGGGA CCCTCGAGAG CGATGCCGAT GGATTTGATT 120
TTAGTTGTGT GGTTCTGTGT GTGCACTGCC AGGACAGTGG TGGGCTTTGG GATGGACCCT 180
GACCTTCAGA TGGATATCGT CACCGAGCTT GACCTTGTGA ACACCACCCT TGGAGTTGCT 240
CAGGTGTCTG GAATGCACAA TGCCAGCAAA GCATTTTTAT TTCAAGACAT AGAAAGAGAG 300
ATCCATGCAG CTCCTCATGT GAGTGAGAAA TTAATTCAGC TGTTCCAGAA CAAGAGTGAA 360
TTCACCATTT TGGCCACTGT ACAGCAGAAG CCATCCACTT CACCAGTGAT ACTGTCCATT 420
CGAGAACTGG AGCACAGCTA TTTTGAACTG GAGAGCAGTG GCCTGACCGA TGAGATTCGG 480
TATCACTACA TACACAATGG GAAGCCAAGG ACAGAGGCAC TTCCTTACCG CATGGCAGAT 540
GGACAATGGC ACAAGGTTGC ACTGTCAGTT AGCGCCTCTC ATCTCCTGCT CCATGTCGAC 600
TGTAACAGCA TTTATGAGCG TGTGATAGAC CCTCCAGATA CCAACCTTCC CCCAGGAATC 660
AATTTATGGC TTGGCCAGCG CAACCAAAAG CATGGCTTAT TCAAAGGGAT CATCCAAGAT 720
GGGAAGATCA TCTTTATGCC GAATGGATAT ATAACACAGT GTCCAAATCT AAATCACACT 780
TGCCCAACCT GCAGTGATTT CTTAAGCCTG GTGCAAGGAA TAATGGATTT ACAAGAGCTT 840
TTGGCCAAGA TGACTGCAAA ACTAAATTAT GCAGAGACAA GACTTAGTCA ATTGGAAAAC 900
TGTCATTGTG AGAAGACTTG TCAAGTGAGT GGACTGCTCT ATCGAGATCA AGACTCTTGG 960
GTAGATGGTG ACCATTGCAG GAACTGCACT TGCAAAAGTG GTGCCGTGGA ATGCCGAAGG 1020
ATGTCCTGTC CCCCTCTCAA TTGCTCCCCA GACTCCCTCC CAGTACACAT TGCTGCCCAG 1080
TGCTGTAAGG TCTGCCGACC AAAATGTATC TATGGAGGAA AAGTTCTTGC AGAAGGCCAG 1140
CGGATTTTAA CCAAGAGCTG TCGGGAATGC CGAGGTGGAG TTTTAGTAAA AATTACAGAA 1200
ATGTGTCCTC CTTTGAACTG CTCAGAAAAG GATCACATTC TTCCTGAGAA TCAGTGCTGC 1260
CGTGTCTGTA GAGGTCATAA CTTTTGTGCA GAAGGACCTA AATGTGGTGA AAACTCAGAG 1320
TGCAAAAACT GGAATACAAA AGCTACTTGT GAGTGCAAGA GTGGTTACAT CTCTGTCCAG 1380
GGAGACTCTG CCTACTGTGA AGATATTGAT GAGTGTGCAG CTAAGATGCA TTACTGTCAT 1440
GCCAATACTG TGTGTGTCAA CCTTCCTGCG TTATATCGCT GTGACTGTGT CCCAGGATAC 1500
ATTCGTGTGG ATGACTTCTC TTGTACAGAA CACGATGAAT GTGGCAGCGG CCAGCACAAC 1560
TGTGATGAGA ATGCCATCTG CACCAACACT GTCCAGGGAC ACAGCTGCAC CTGCAAACCG 1620
GGCTACGTGG GGAACGGGAC CATCTGCAGA GCTTTCTGTG AAGAGGGCTG CAGATACGGT 1680
GGAACGTGTG TGGCTCCCAA CAAATGTGTC TGTCCATCTG GATTCACAGG AAGCCACTGC 1740
GAGAAAGATA TTGATGAATG TTCAGAGGGA ATCATTGAGT GCCACAACCA TTCCCGCTGC 1800
GTTAACCTGC CAGGGTGGTA CCACTGTGAG TGCAGAAGCG GTTTCCATGA CGATGGGACC 1860
TATTCACTGT CCGGGGAGTC CTGTATTGAC ATTGATGAAT GTGCCTTAAG AACTCACACC 1920
TGTTGGAACG ATTCTGCCTG CATCAACCTG GCAGGGGGTT TTGACTGTCT CTGCCCCTCT 1980
CCGCCCTCCT GCTCTGGTGA CTGTCCTCAT GAAGGGGGGC TGAAGCACAA TGGCCAGGTG 2040
TGGACCTTGA AAGAAGACAG GTGTTCTGTC TGCTCCTGCA AGGATGGCAA GATATTCTGC 2100
CGACGGACAG CTTGTGATTG CCAGAATCCA AGTGCTGACC TATTCTGTTG CCCAGAATGT 2160
GACACCAGAG TCACAAGTCA ATGTTTAGAC CAAAATGGTC ACAAGCTGTA TCGAAGTGGA 2220
GACAATTGGA CCCATAGCTG TCAGCAGTGT CGGTGTCTCC AAGGAGAGGT AGATTGCTGG 2280
CCACTCACTT GCCCCAACTT GAGCTGTGAG TATACAGCTA TCTTAGAAGG GGAATGTTGT 2340
CCCCGCTGTG TCAGTGACCC CTGCCTAGCT GATAACATCA CCTATGACAT CAGAAAAACT 2400
TGCCTGGACA GCTATG TGT TTCACGGCTT AGTGGCTCAG TGTGGACGAT GGCTGGATCT 2460
CCCTGCACAA CCTGTAAATG CAAGAATGGA AGAGTCTGTT GTTCTGTGGA TTTTGAGTGT 2520
CTTCAAAATA ATTGAAGTAT TTACAGTGGA CTCAACGCAG AAGAATGGAC GAAATGACCA 2580
TCCAACGTGA TTAAGGATAG GAATCGGTAG TTTGGTTTTT TTGTTTGTTT TGTTTTTTTA 2640
ACCACAGATA ATTGCCAAAG TTTCCACCTG AGGACGGTGT TTCCCAGGTT GCCTTTTGGA 2700
CCTACCACTT TGCTCATTCT TGCTAACCTA GTCTAGGTGA CCTACAGTGC CGTGCATTTA 2760
AGTCAATGGT TGTTAAAAGA AGTTTCCCGT GTTGTAAATC ATGTTTCCCT TATCAGATCA 2820
TTTGCAAATA CATTTAAATG ATCTCATGGT AAATGGTTGA TGTATTTTTT GGGTTTATTT 2880
TGTGTACTAA CCATAATAGA GAGAGACTCA GCTCCTTTTA TTTATTTTGT TGATTTATGG 2940
ATCAAATTCT AAAATAAAGT TGCCTGTTGT GACTTTT 2977
Seq ID NO 194 DNA Sequence
Nucleic Acid Accession « NM_016180 1
Coding sequence 26 1618
1 11 21 31 41 SI
I I I I I I
CAGCAAGGTT CCTCTCCCAG TGGCCATGGG TAGCAACAGT GGGCAGGCTG GCCGCCACAT 60
CTATAAATCC CTAGCTGATG ATGGCCCCTT TGACTCTGTG GAGCCGCCTA AAAGACCCAC 120
CAGCAGACTC ATCATGCACA GCATGGCCAT GTTCGGAAGA GAGTTCTGCT ACGCGCTGGA 180
GGCAGCGTAT GTGACCCCAG TCCTGCTCAG CGTAGGTCTG CCCAGCAGCC TGTACAGCAT 240
TGTGTGGTTC CTCAGCCCCA TCCTGGGATT CCTGCTGCAG CCCGTGGTCG GATCGGCCAG 300
CGACCACTGC CCCTCCAGGT GGGGCCGCCG GAGACCCTAC ATCCTCACCC TGGGAGTCAT 360
GATGCTCGTG GGCATGGCTC TGTACCTCAA TGGGGCTACT GTTGTAGCAG CTTTGATTGC 420
TAACCCAAGG AGGAAGCTGG TTTGGGCCAT AAGTGTCACC ATGATAGGTG TCGTTCTCTT 480
TGATTTTGCT GCCGACTTCA TTGATGGGCC CATCAAAGCC TACTTATTTG ATGTCTGCTC 540
CCATCAGGAC AAGGAGAAGG GCCTCCACTA CCATGCCCTC TTCACAGGTT TTGGAGGTGC 600
CCTGGGTTAC CTTTTGGGTG CTATAGACTG GGCCCATCTG GAGCTGGGAA GACTGTTGGG 660 TACAGAATTC CAGGTCATGT TCTTCTTCTC TGCATTGGTG CTCACTTTGT GTTTTACTGT 720
TCATCTGTGC AGTATCTCTG AAGCCCCACT TACAGAGGTT GCAAAGGGCA TTCCCCCACA 780
GCAAACCCCT CAGGACCCTC CATTGTCATC AGATGGAATG TACGAGTATG GTTCTATCGA 840
GAAAGTTAAA AATGGTTACG TAAATCCAGA GCTGGCAATG CAGGGAGCAA AAAACAAAAA 900
TCATGCTGAA CAGACTCGCA CCGCAATGAC ATTAAAGTCA CTGCTGAGAG CACTCCTGAA 960
CATGCCTCCT CACTACCGCT ACCTTTGCAT CAGCCACCTC ATTGGATGGA CGGCCTTCCT 1020
GTCCAACATG CTGTTCTTCA CAGATTTCAT GGGCCAGATT GTGTACCGCG GGGATCCCTA 1080
TAGTGCACAC AACTCCACAG AGTTTCTCAT CTACGAAAGA GGAGTCGAGG TTGGATGTTG 1140
GGGCTTCTGC ATCAACTCCG TGTTTTCCTC ACTTTATTCT TACTTTCAGA AAGTTTTGGT 1200
ATCCTACATT GGATTAAAGG GTCTTTACTT CACGGGATAT TTGCTGTTTG GCCTGCCGAC 1260
GGGATTTATT GCGCTCTTCC CGAATGTCTA CTCCACCCTG GTCCTGTGCA GCCTGTTTGG 1320
TGTAATGTCC AGCACCCTGT ACACTGTGCC CTTTAACCTC ATTACTGAGT ACCACCGCGA 1380
GGAAGAAAAG GAGAGGCAGC AGGCCCCAGG AGGGGACCCA GACAACAGCG TGAGAGGGAA 1440
GGGCATGGAC TGCGCCACCC TCACATGCAT GGTGCAGCTG GCTCAGATCC TGGTCGGAGG 1500
TGGCCTG GC TTTCTCCTCA ACACAGCCGG GACCGTTGTC GTCGTGGTGA TCACAGCGTC 1560
TGCGGTGGCA CTGATAGGCT GTTGCTTTGT CGCTCTCTTT GTTAGATATG TGGATTAGGT 1620
CAATAAAGAG ACAATGACCC TAAAAAAAAA 16SO
Seq ID NO 195 DNA Sequence
Nucleic Acid Accession tt NM_012400 2
Coding sequence 18 455
1 11 21 31 41 51
1 1 1 1 1 1 TGCTCTGTGC TGGGATCATG GAACTTGCAC TGCTGTGTGG GCTCCTGGTG ATGGCTGGTG 60
TGATTCCAAT CCAGGGCGGG ATCCTGAACC TGAACAAGAT GGTCAAGCAA GTGACTGGGA 120
AAATGCCCAT CCTCTCCTAC TGGCCCTACG GCTGTCACTG CGGACTAGGT GGCAGAGGCC 180
AACCCAAAGA TGCCACGCAC TGGTGCTGCC AGACCCATGA CTGCTGCTAT GACCACCTGA 240
AGACCCAGGG GTGCAGCATC TACAAGGACT ATTACAGATA CAACTTTTCC CAGGGGAACA 300
TCCACTGCTC TGACAAGGGA AGCTGGTGTG AGCAGCAGCT GTGTGCCTGT GACAAGGAGG 360
TGGCCTTCTG CCTGAAGCGC AACCTGGACA CCTACCAGAA GCGACTGCGT TTCTACTGGC 420
GGCCCCACTG CCGGGGGCAG ACCCCTGGGT GCTAGAAGCC CACACCCTCT ACCCTGTTCC 480
TCAGCATGGA GCTCTGGCAT CCCCACCTCA GTATCTAACC TGAACCAGCC TGGCTTTTCA 540
AACACTCCGG GGGGAGGTAG TCCCAGCCTC CCCCGGAACC CTCTACCAAT GCCTTCTGAC 600
CTTCTGAAGC TTTCCGAATC CTCCCAGTTG AGGCAGTAGC TGTGTCCTCT GAGGGTGGAT 660
GGGAATCTTG GGAGAAGCCC AAGCAAGCGA GCCCTCAGAG GTGGTGTTTG GACCAAAGCA 720
TCGGGGTGGG GGAGGGGTCT GCCGCTGTCC CCCACCTGCT GGCCCCCTTG TCCTTCCTCA 780
CCCCCTCCAA TATAGTCTCG GAGCTACAAC CGCAGCAGCC ACTATAAAGG GCAATATTGA 840
TCTTTCTGTC CATGTGGCTC TATCTTTTAA AACCTCAAGG CCCTCCACTG TCCTAAGATA 900
AAGCCTCTCA TAGGCACTGC GGACCCTGCA CAGTCTGGCC ATGTGACCCT CTCCCCAGGC 960
AAGCTCTGAA GTCCCTGCAG GTGGAGGCCA TGCCTGTCTT AAACTCAGTT GCATCCCTGG 1020
TGCCCAAAGC AACACCAGAA CCAAGAAGGA GCTCCATAAA TCCTTCTTGG GTGAAGCCTA 1080
GACAAAGCCG CCAGGTCTTG TGGCTCCAGG CACCAGAGCC TTGAGTACTT TCTCCTGCCT 1140
CCAGGCATTG GCTCAGGGTG AATTACAAGG GCCTACTGAA TGGCTATTAC TTTCATCACG 1200
ACTGATCCCC ACCTCCTCAG GGTCAAAGGG CTACTTTCTG GAAGTCTCCC CAGGCTGACT 1260
CCTTCTCCCT GACTGCAACC GCTCACTCCC TCCTCCAAGC TCCCACAATG CTTCATG CT 1320
CTGCCGCTTA CCTAGCTTGG CCTAGAGTGG CAAATGGAAC TTCTCTGATC TCCCCCAACT 1380
AGACTGGAGC CCCCGAAGGA TGGAGACCAT GTCTGTGCCA TCTCTGTTTC CCCTGTTTTC 1440
CCACATACTA GGTGCTCAAT TCATGCCTGT GAATGGCGTG AGCCCATAAT GGATACACAG 1S00
AGGTTGCAGC AGATGGTGTG GGTACCTCAC CCAGATATCA TCCAGGCCCA AGGCCCCTCT 1560
CCCTGAGTGA GGCCAGGTGT TGGCAGCCAA CTGCTCCAAT CTGCCTCCTT CCCCTAAATA 1620
CTGCCCTCCT CTAGTGGGAG CTGCCTTCCC CCTGCCCCAC CTCTCCCACC AAGAGGCCAC 1680
CTGTCACTCA TGGCCAGCAG AGTGACACCA TGGAGGGTAC AATTGCCAGC TCCCCCGTGT 1740
CTGTGCAGGA TTGTCTGGGT TGAATGACAC TCTCAAATTG TTCCTGCGAT CGGGCTGAGG 1800
CCAGGCCTCT CCTGGAACCA CCTCTCTGCT TGGTCTGACC CCTTGCCCTA TCCAGTTTTC 1860
CTGGTTCCCT CACAGGTTTC TCCAGAAAGT ACTCCCTCAG TAAAGCATTT GCACAAGAAT 1920
CCTTGTCTCA GGCTCTGCTT CTAAGGAAAG AGACTGAAGA GGGACAACTT TTTCCTATGA 1980
GGACTCCCAA TCTGCCATTT GTGTGTGGCT AGCTGTTTCC AGCCAGCGGG CTGAGGCACC 2040
TGCAGTCACC CACACTCTGG GCCTGTGGCA CCATCTGTGC CTCAGCTGAC TGAGCAGTTC 2100
TGAGATGTGG TGACTCATGT GAAGTGGTGT CATAGGAATG AAGGACTGTG GGCGCTGGGT 2160
TCAAATTCCA GTTCTATGCA CCACTCCAGG TAGGGATACC CATGGGGGCA GCTGTGCCTG 2220
TGTGGGGGAA CAGGGTAGGG AAATCTCCAT ACCTTCTCAA TTTTGCTGTG AACCTAAAAC 2280
TGCCATATAA AGATAAAGTC TAGGCCAGGC ATGGTGGCTC ATGCCTGTAA TCCCAACACT 2340
TAGGGTGGCT GAGGCAGGCA GATCACCTGG CCTCAGGAGT TCAAGACCAG CCTGCCCAAC 2400
ATGGCAAAAC CTCGTCTCTA CTAAAAATAC AAAAATTAGC CAGGCATCGT GGTGGGTGCC 2460
TGTAATCCCA GCTATTCAGG AGGCTGAGGC AGGAGAATCA CTTGGACCTG GGAGGCAGAG 2520
GTTTCAGTGA GCCCAGATCG CGACACTGCA CTCCAGCCTG GGCAACAGAG TGACACTCTG 2580
TCTCAAAAAA TAAAATAAAA TAAAATAAAA TAAAATAAAA TAAAATAAAA AAAAAAAAAA 2640
AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 2700
AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAA 2747
Seq ID NO 196 DNA Sequence
Nucleic Acid Accession tt NM_018833 1
Coding sequence 80 2041
1 11 21 31
GAGGTTGGGA GAGACGGAGC GGACCTCAGC GCTGAAGCAG AAGTCCCCGG AGCTGCCCTC 60
TCCCCGCCGC GGCTGAGCCA TGCCCCTCCC TGACCTGAGA CCCTGGACCT CCCTGCTGCT 120
GGTGGACGCG GCTTTACTGT GGCTGCTTCA GGGCCCTCTG GGGACTTTGC TTCCTCAAGG 180
GCTGCCAGGA CTATGGCTGG AGGGGACCCT GCGGCTGGGA GGGCTGTGGG GGCTGCTAAA 240
GCTAAGAGGG CTGCTGGGAT TTGTGGGGAC ACTGCTGCTC CCGCTCTGTC TGGCCACCCC 300
CCTGACTGTC TCCCTGAGAG CCCTCCTCGC GGGGGCCTCA CGTGCTCCCC CAGCCAGAGT 360
CGCTTCAGCC CCTTGGAGCT GGCTGCTCCT GGGGTACGGG GCTGCGGGGC TCAGCTCCTC 420
ACTGTGGGCT GTTCTGAGCC CTCCTCCAGC CCAGGAGAAG GAGCACCACC AGGTGAACAA 480
CAAAGTCTTG ATGTGGAGGC TGCTGAAGCT CTCCAGGCCG GACCTGCCTC TCCTCGTTGC 540 CGCCTTCTTC TTCCTTGTCC TTGCTGTTTT GGGTGAGACA TTAATCCCTC ACTATTCTGG 600
TCGTGTCATT GACATCCTGG GAGGTGATTT TGACCCCCAT GCCTTTGCCA GTGCCATCTT 660
CTTCATGTGC CTCTTCTCCT TTGGCAGCTC ACTGTCTGCA GGCTGCCGAG GAGGCTGCTT 720
CACCTACACC ATGTCTCGAA TCAACTTGCG GATCCGGGAG CAGCTTTTCT CCTCCCTGCT 780
GCGCCAGGAC CTCGGTTTCT TCCAGCAGAC TAAGACAGGG GAGCTGAACT CACGGCTGAG 8 0
CTCGGATACC ACCCTGATGA GTAACTGGCT TCCTTTAAAT GCCAATGTGC TCTTGCGAAG 900
CCTCCTGAAA GTGGTGGGGC TGTATGGCTT CATGCTCAGC ATATCGCCTC GACTCACCCT 960
CCTTTCTCTG CTGCACATGC CCTTCACAAT AGCAGCGGAG AAGGTGTACA ACACCCGCCA 1020
TCAGGAAGTG CTTCGGGAGA TCCAGGATGC AGTGGCCAGG GCG GGCACC TGGTGCGGGA 1080
AGCCGTTGGA GGGCTGCAGA CCGTTCGCAG TTTTGGGGCC GAGGAGCATG AAGTCTGTCG 1140
CTATAAAGAG GCCCTTGAAC AATGTCGGCA GCTGTATTGG CGGAGAGACC TGGAACGCGC 1200
CTTGTACCTG CTCATAAGGA GGGTGCTGCA CTTGGGTGTG CAGATGCTGA TGCTGAGCTG 1260
TGGGCTGCAG CAGATGCAGG ATGGGGAGCT CACCCAGGGC AGCCTGCTTT CCTTTATGAT 1320
CTACCAGGAG AGCGTGGGGA GCTATGTGCA GACCCTGGTA TACATATATG GGGATATGCT 1380
CAGCAACGTG GGAGCTGCAG AGAAGGTTTT CTCCTACATG GACCGACAGC CAAATCTGCC 1440
TTCACCTGGC ACGCTTGCCC CCACCACTCT GCAGGGGGTT GTGAAATTCC AAGACGTCTC 1500
CTTTGCATAT CCCAATCGCC CTGACAGGCC TGTGCTCAAG GGGCTGACGT TTACCCTACG 1560
TCCTCCTGAG GTGACGGCGC TCCTGGGACC CAATGGGTCT GGGAAGAGCA CAGTGGCTGC 1620
CCTGCTGCAG AATCTGTACC AGCCCACAGG GGGACAGGTG CTGCTGGATG AAAAGCCCAT 1680
CTCACAGTAT GAACACTGCT ACCTGCACAG CCAGGTGGTT TCAGTTGGGC AGGAGCCTGT 1740
GCTGTTCTCC GGTTCTGTGA GGAACAACAT TGCTTATGGG CTGCAGAGCT GCGAAGATGA 1800
TAAGGTGATG GCGCCTGCCC AGGCTGCCCA CGCAGATGAC TTCATCCAGG AAATGGAGCA 1860
TGGAATATAC ACAGATGTAG GGGAGAAGGG AAGCCAGCTG GCTGCGGGAC AGAAACAACG 1920
TCTGCCCATT GCCCGGGCCC TTGTACGAGA CCCGCGGGTC CTCATCCTGG ATGAGGCTAC 1980
TAGTGCCCTA GATGTGCAGT GCGAGCAGGC CAAAACCCTT TGGAAGTTCA TGATATTTTG 2040
AATTTCAATG GATATTTCCT GGGAATAATG AGTTCAAATG AACGAATATG TGGAACAAAG 2100
CATCACCAAC ATTTATTTTT TCAGGATGAG GTGATGGACA AAACCATCAC AGGGAAATTG 2160
AGGCAAATAG TACATGTAAA ACAATACTTC GGGTGAGTCC ACCTATCCCA AAGTCGTATC 2220
AAAGAAGTGG CTGCAGATTG GAGCCCAAAG CCTTTGGTTC CTCAGTTTCC AAATGGATTC 2280
TCACTAGGTG GGATCATGAG TTTGCTTTCC ACACCCCAAA TTCTAACTAT TTCTTTTGTT 2340
TCTTACATCC TTTCCCTCTT CCCCAGCCCC TTCCCCTCAT GTTACACCTC TTGCTCCTTT 2400
GAGACGTCAA TCACCACTGA GAAAGAATTA AACCAGTATT TTGAGCTGGC AAAATTCTTA 2460
GCCTAGTACA ATTCCTTCAA TTAAACTGTA GCTCAAC 2497
Seq ID NO- 197 DNA Sequence
Nucleic Acid Accession tt ■ NM_002416
Coding sequence: 40-417
1 11 21 31 41 51
I I I I I I
ATCCAATACA GGAGTGACTT GGAACTCCAT TCTATCACTA TGAAGAAAAG TGGTGTTCTT 60
TTCCTCTTGG GCATCATCTT GCTGGTTCTG ATTGGAGTGC AAGGAACCCC AGTAGTGAGA 120
AAGGGTCGCT GTTCCTGCAT CAGCACCAAC CAAGGGACTA TCCACCTACA ATCCTTGAAA 180
GACCTTAAAC AATTTGCCCC AAGCCCTTCC TGCGAGAAAA TTGAAATCAT TGCTACACTG 240
AAGAATGGAG TTCAAACATG TCTAAACCCA GATTCAGCAG ATGTGAAGGA ACTGATTAAA 300
AAGTGGGAGA AACAGGTCAG CCAAAAGAAA AAGCAAAAGA ATGGGAAAAA ACATCAAAAA 360
AAGAAAGTTC TGAAAGTTCG AAAATCTCAA CGTTCTCGTC AAAAGAAGAC TACATAAGAG 420
ACCACTTCAC CAATAAGTAT TCTGTGTTAA AAATGTTCTA TTTTAATTAT ACCGCTATCA 480
TTCCAAAGGA GGATGGCATA TAATACAAAG GCTTATTAAT TTGACTAGAA AATTTAAAAC 540
ATTACTCTGA AATTGTAACT AAAGTTAGAA AGTTGATTTT AAGAATCCAA ACGTTAAGAA 600
TTGTTAAAGG CTATGATTGT CTTTGTTCTT CTACCACCCA CCAGTTGAAT TTCATCATGC 660
TTAAGGCCAT GATTTTAGCA ATACCCATGT CTACACAGAT GTTCACCCAA CCACATCCCA 720
CTCACAACAG CTGCCTGGAA GAGCAGCCCT AGGCTTCCAC GTACTGCAGC CTCCAGAGAG 780
TATCTGAGGC ACATGTCAGC AAGTCCTAAG CCTGTTAGCA TGCTCCTGAG CCAAGCAGTT 840
TGAAATTGAG CTGGACCTCA CCAAGCTGCT GTGGCCATCA ACCTCTGTAT TTGAATCAGC 900
CTACAGGCCT CACACACAAT GTGTCTGAGA GATTCATGCT GATTGTTATT GGGTATCACC 960
ACTGGAGATC ACCAGTGTGT GGCTTTCAGA GCCTCCTTTC TGGCTTTCCA AGCCATGTGA 1020
TTCCATCTTG CCCGCTCAGG CTGACCACTT TATTTCTTTT TGTTCCCCTT TGCTTCATTC 1080
AAGTCAGCTC TTCTCCATCC TACCACAATG CAGTGCCTTT CTTCTCTCCA GTGCACCTGT 1140
CATATGCTCT GATTTATCTG AGTCAACTCC TTTCTCATCT TGTCCCCAAC ACCCCACAGA 1200
AGTGCTTTCT TCTCCCAATT CATCCTCACT CAGTCCAGCT TAGTTCAAGT CCTGCCTCTT 1260
AAATAAACCT TTTTGGACAC ACAAATTATC TTAAAACTCC TGTTTCACTT GGTTCAGTAC 1320
CACATGGGTG AACACTCAAT GGTTAACTAA TTCTTGGGTG TTTATCCTAT CTCTCCAACC 1380
AGATTGTCAG CTCCTTGAGG GCAAGAGCCA CAGTATATTT CCCTGTTTCT TCCACAGTGC 1440
CT AAT AAT AC TGTGGAACTA GGTTT AATA ATTTTTTAAT TGATGTTGTT ATGGGCAGGA 1500
TGGCAACCAG ACCATTGTCT CAGAGCAGGT GCTGGCTCTT TCCTGGCTAC TCCATGTTGG 1S60
CTAGCCTCTG GTAACCTCTT ACTTATTATC TTCAGGACAC TCACTACAGG GACCAGGGAT 1620
GATGCAACAT CCTTGTCTTT TTATGACAGG ATGTTTGCTC AGCTTCTCCA ACAATAAGAA 1680
GCACGTGGTA AAACACTTGC GGATATTCTG GACTGTTTTT AAAAAATATA CAGTTTACCG 1740
AAAATCATAT AATCTTACAA TGAAAAGGAC TTTATAGATC AGCCAGTGAC CAACCTTTTC 1800
CCAACCATAC AAAAATTCCT TTTCCCGAAG GAAAAGGGCT TTCTCAATAA GCCTCAGCTT 1860
TCTAAGATCT AACAAGATAG CCACCGAGAT CCTTATCGAA ACTCATTTTA GGCAAATATG 1920
AGTTTTATTG TCCGTTTACT TGTTTCAGAG TTTGTATTGT GATTATCAAT TACCACACCA 1980
TCTCCCATGA AGAAAGGGAA CGGTGAAGTA CTAAGCGCTA GAGGAAGCAG CCAAGTCGGT 2040
TAGTGGAAGC ATGATTGGTG CCCAGTTAGC CTCTGCAGGA TGTGGAAACC TCCTTCCAGG 2100
GGAGGTTCAG TGAATTGTGT AGGAGAGGTT GTCTGTGGCC AGAATTTAAA CCTATACTCA 2160
CTTTCCCAAA TTGAATCACT GCTCACACTG CTGATGATTT AGAGTGCTGT CCGCTGGAGA 2220
TCCCACCCGA ACGTCTTATC TAATCATGAA ACTCCCTAGT TCCTTCATGT AACTTCCCTG 2280
AAAAATCTAA GTGTTTCATA AATTTGAGAG TCTGTGACCC ACTTACCTTG CATCTCACAG 2340
GTAGACAGTA TATAACTAAC AACCAAAGAC TACATATTGT CACTGACACA CACGTTATAA 2400
TCATTTATCA TATATATACA TACATGCATA CACTCTCAAA GCAAATAATT TTTCACTTCA 2460
AAACAGTATT GACTTGTATA CCTTGTAATT TGAAATATTT TCTTTGTTAA AATAGAATGG 2520 TATCAATAAA TAGACCATTA ATCAG
Seq ID NO - 198 DNA Sequence Nucleic Acid Accession # NM_006533 1
Coding sequence 72 467
1 11 21 31 41 51
I I I I I I
AGGGAGAGAG GGAGGGGAGG AAATTGGAGA CCCCAGCACC CCCTTGCTCA CTCTCTTGCT 60
CACAGTCCAC GATGGCCCGG TCCCTCCTGT GCCTTGGTGT CATCATCTTG CTGTCTGCCT 120
TCTCCGGACC TGGTGTCAGG GGTGGTCCTA TGCCCAAGCT GGCTGACCGC AAGCTGTGTG 180
CGGACCAGGA GTGCAGCCAC CCTATCTCCA TGGCTGTGGC CCTTCAGGAC TACATGGCCC 240
CCGACTGCCG ATTCCTGACC ATTCACCGGG GCCAAGTGGT GTATGTCTTC TCCAAGCTGA 300
AGGGCCGTGG GCGGCTCTTC TGGGGAGGCA GCGTTCAGGG AGATTACTAT GGAGATCTGG 360
CTGCTCGCCT GGGCTATTTC CCCAGTAGCA TTGTCCGAGA GGACCAGACC CTGAAACCTG 420
GCAAAGTCGA TGTGAAGACA GACAAATGGG ATTTCTACTG CCAGTGAGCT CAGCCTACCG 480
CTGGCCCTGC CGTTTCCCCT CCTTGGGTTT ATGCAAATAC AATCAGCCCA GTGCAAAC 538
Seq ID NO 199 Protein sequence
Protein Accession tt NP_002412 1
1 11 21 31 41 51
I I I I I I
MHSFPPLL L FWGWSHSF PATLETQEQD VDLVQKYLEK YYN KNDGRQ VEKRRNSGPV 60 VEK KQMQEF FG KVTGKPD AETLKVMKQP RCGVPDVAQF V TEGNPRWE QTHLTYRIEN 120
YTPDLPRADV DHAIEKAFQL WSNVTPLTFT KVSEGQADIM ISFVRGDHRD NSPFDGPGGN 180
LAHAFQPGPG IGGDAHFDED ERWTNNFREY NLHRVAAHEL GHSLG SHST DIGALMYPSY 240
TFSGDVQLAQ DDIDGIQAIY GRSQNPVQPI GPQTPKACDS K TFDAITTI RGEVMFFKDR 300
FYMRTNPFYP EVE NFISVF WPQLPNGLEA AYEFADRDEV RFFKGNKYVJA VQGQNVLHGY 360 PKDIYSSFGF PRTVKHIDAA LSEENTGKTY FFVANKYWRY DEYKRSMDPG YPKMIAHDFP 420 GIGHKVDAVF MKDGFFYFFH GTRQYKFDPK TKRILTLQKA NSWFNCRKN
Seq ID NO 200 Protein sequence
Protein Accession # NP_002412 1
1 11 21 31 41 51
I I I I I I
MHSFPPLLLL LFWGWSHSF PATLETQEQD VDLVQKYLEK YYNLKNDGRQ VEKRRNSGPV 60
VEKLKQMQEF FGLKVTGKPD AETLKVMKQP RCGVPDVAQF VLTEGNPRWE QTHLTYRIEN 120
YTPDLPRADV DHAIEKAFQL WSNVTPLTFT KVSEGQADIM ISFVRGDHRD NSPFDGPGGN 180
LAHAFQPGPG IGGDAHFDED ERWTNNFREY NLHRVAAHAL GHSLGLSHST DIGALMYPSY 240
TFSGDVQLAQ DDIDGIQAIY GRSQNPVQPI GPQTPKACDS KLTFDAITTI RGEVMFFKDR 300
FYMRTNPFYP EVELNFISVF WPQLPNGLEA AYEFADRDEV RFFKGNKYWA VQGQNVLHGY 360
PKDIYSSFGF PRTVKHIDAA LSEENTGKTY FFVANKYWRY DEYKRSMDPG YPKMIAHDFP 420 GIGHKVDAVF MKDGFFYFFH GTRQYKFDPK TKRILTLQKA NSWFNCRKN
Seq ID NO 201 Protein sequence
Protein Accession It NP_002413
1 11 21 31 41 51
I I I I I I
MKSLPILLLL CVAVCSAYPL DGAARGEDTS MNLVQKYLEN YYDLEKDVKQ FVRRKDSGPV 60
VKKIREMQKF LGLEVTGKLD SDTLEVMRKP RCGVPDVGHF RTFPGIPKWR KTHLTYRIVN 120
YTPDLPKDAV DSAVEKALKV WEEVTPLTFS RLYEGEADIM ISFAVREHGD FYPFDGPGNV 180
LAHAYAPGPG INGDAHFDDD EQWTKDTTGT NLFLVAAHEI GHSLGLFHSA NTEALMYPLY 240
HSLTDLTRFR LSQDDINGIQ SLYGPPPDSP ETPLVPTEPV PPEPGTPANC DPALSFDAVS 300
TLRGEILI FK DRHFWRKSLR KLEPELHLIS SFWPSLPSGV DAAYEVTSKD LVFIFKGNQF 360
WAIRGNEVRA GYPRGIHTLG FPPTVRKIDA AISDKEKNKT YFFVEDKYWR FDEKRNSMEP 420 GFPKQIAEDF PGIDSKIDAV FEEFGFFYFF TGSSQLEFDP NAKKVTHTLK SNSWLNC
Seq ID NO 202 Protein Sequence
Protein Accession If NP_001845
1 11 21 31 41 51
I I I I I I
MEPWSSRWKT KRWLWDFTVT TLALTFLFQA REVRGAAPVD VLKALDFHNS PEGISKTTGF 60
CTNRKNSKGS DTAYRVSKQA QLSAPTKQLF PGGTFPEDFS ILFTVKPKKG IQSFLLSIYN 120
EHGIQQIGVE VGRSPVFLFE DHTGKPAPED YPLFRTVNIA DGKWHRVAIS VEKKTVTMIV 180
DCKKKTTKPL DRSERAIVDT NGITVFGTRI LDEEVFEGDI QQFLITGDPK AAYDYCEHYS 240
PDCDSSAPKA AQAQEPQIDE YAPEDIIEYD YEYGEAEYKE AESVTEGPTV TEETIAQTEA 300
NIVDDFQEYN YGTMESYQTE APRHVSGTNE PNPVEEIFTE EYLTGEDYDS QRKNSEDTLY 360
ENKEIDGRDS DLLVDGDLGE YDFYEYKEYE DKPTSPPNEE FGPGVPAETD ITETSINGHG 420
AYGEKGQKGE PAWEPGMLV EGPPGPAGPA GIMGPPGLQG PTGPPGDPGD RGPPGRPGLP 480
GADGLPGPPG TMLMLPFRYG GDGSKGPTIS AQEAQAQAIL QQARIALRGP PGPMGLTGRP 540
GPVGGPGSSG AKGESGDPGP QGPRGVQGPP GPTGKPGKRG RPGADGGRGM PGEPGAKGDR 600
GFDGLPGLPG DKGHRGERGP QGPPGPPGDD GMRGEDGEIG PRGLPGEAGP RGLLGPRGTP 660
GAPGQPGMAG VDGPPGPKGN MGPQGEPGPP GQQGNPGPQG LPGPQGPIGP PGEKGPQGKP 720
GLAGLPGADG PPGHPGKEGQ SGEKGALGPP GPQGPIGXPG PRGVKGADGV RGLKGSKGEK 780
GEDGFPGFKG DMGLKGDRGE VGQIGPRGXD GPEGPKGRAG PTGDPGPSGQ AGEKGKLGVP 840
GLPGYPGRQG PKGSTGFPGF PGANGEKGAR GVAGKPGPRG QRGPTGPRGS RGARGPTGKP 900
GPKGTSGGDG PPGPPGERGP QGPQGPVGFP GPKGPPGPPG RMGCPGHPGQ RGETGFQGKT 960
GPPGPGGWG PQGPTGETGP IGERGYPGPP GPPGEQGLPG AAGKEGAKGD PGPQGISGKD 1020
GPAGLRGFPG ERGLPGAQGA PGLKGGEGPQ GPPGPVGSPG ERGSAGTAGP IGLRGRPGPQ 1080
GPPGPAGEKG APGEKGPQGP AGRDGVQGPV GLPGPAGPAG SPGEDGDKGE IGEPGQKGSK 1140
GGKGENGPPG PPGLQGPVGA PGIAGGDGEP GPRGQQGMFG QKGDEGARGF PGPPGPIGLQ 1200
GLPGPPGEKG ENGDVGPWGP PGPPGPRGPQ GPNGADGPQC PPGSVGSVGG VGEKGEPGEA 1260
GNPGPPGEAG VGGPKGERGE KGEAGPPGAA GPPGAKGPPG DDGPKGNPGP VGFPGDPGPP 1320
GELGPAGQDG VGGDKGEDGD PGQPGPPGPS GEAGPPGPPG KRGPPGAAGA EGRQGEKGAK 1380
GEAGAEGPPG KTGPVGPQGP AGKPGPEGLR GIPGPVGEQG LPGAAGQDGP PGPMGPPGLP 1440
GLKGDPGSKG EKGHPGLIGL IGPPGEQGEK GDRGLPGTQG SPGAKGDGGI PGPAGPLGPP 1500
GPPGLPGPQG PKGNKGSTGP AGQKGDΞGLP GPPGPPGPPG EVIQPLPILS SKKTRRHTEG 1560
MQADADDNIL DYSDGMEEIF GSLNSLKQDI EHMKFPMGTQ TNPARTCKDL QLSHPDFPDG 1620 EYWIDPNQGC SGDSFKVYCN FTSGGETCIY PDKKSEGVRI SSWPKEKPGS WFSEFKRGKL 1680
LSYLDVEGNS INMVQMTFLK LLTASARQNF TYHCHQΞAAW YDVSSGSYDK ALRFLGSNDE 1740
EMSYDNNPFI KTLYDGCTSR KGYEKTVIEI NTPKIDQVPI VDVMISDFGD QNQKFGFEVG 1800 PVCFLG
Seq ID NO 203 Protein sequence
Protein Accession It XP_057014
1 11 21 31 41 51
I I I I I I
10 MRPQGPAASP QRLRGLLLLL LLQLPAPSSA SEIPKGKQKA QLRQREWDL YNGMCLQGPA 60
GVPGRDGSPG ANGIPGTPGI PGRDGFKGEK GECLRESFEE SWTPNYKQCS WSSLNYGIDL 120
GKIAECTFTK MRSNSALRVL FSGSLRLKCR NACCQRWYFT FNGAECSGPL PIEAIIYLDQ 180
GSPEMNSTIN IHRTSSVEGL CEGIGAGLVD VAIWVGTCSD YPKGDASTGW NSVSRIIIEE 240 LPK
15
Seq ID NO 204 Protein sequence
Protein Accession tl Eos sequence
1 11 21 31 41 51
~Λ I I I I I I ) MPGTKLTRTG APADYRVILK TSQEDELDVP DDISVRVMSS QSVLVSWVDP VLEKQKKWA 60
SRQYTVRYRE KGELARWDYK QIANRRVLIE NLIPDTVYEF AVRISQGERD GKWSTSVFQR 120
TPESAPTTAP ENLNVWPVNG KPTWAASWD ALPETEGKVK VCLLDTGLFS VSSFQPSAKS 180
FQNTFFHTPR LSNHLEQSPS PILETLLLPW WMVCSLGNAI FSKSGPQTGE AWDLTPKPSL 240
SLCQQECSCT QKDFSCLAYL IDIQTKQVNK DPQLEGSVFG PCFLFYFLTF MLDIGGFSFI 300
25 MCYEDPVSSL TGNSLKSVAA SKADVQQNTE DNGKPEKPEP SSPSPRAPAS SQHPSVPASP 360
QGRNAKDLLL DLKNKILANG GAPRKPQLRA KKAEELDLQS TEITGEEELG SREDSPMSPS 420
DTQDQKRTLR PPSRHGHSW APGRTAVRAR MPALPRREGV DKPGFSLATQ PRPGAPPSAS 480
ASPAHHASTQ GTSHRPSLPA SLNDNDLVDS DEDERAVGSL HPKGAFAQPR PALSPSRQSP 540
SSVLRDRSSV HPGAKPASPA RRTPHSGAAE EDSSASAPPS RLSPPHGGSS RLLPTQPHLS 600
30 SPLSKGGKDG EDAPATNSNA PSRSTMSSSV SSHLSSRTQV SEGAEASDGE SHGDGDREDG 660
GRQAEATAQT LRARPASGHF HLLRHKPFAA NGRSPSRFSI GRGPRLQPSS SPQSTVPSRA 720
HPRVPSHSDS HPKLSSGIHG DEEDEKPLPA TWNDHVPSS SRQPISRGWE DLRRSPQRGA 780
SLHRKEPIPE NPKSTGADTH PQGKYSSLAS KAQDVQQSTD ADTEGHSPKA QPGSTDRHAS 840
PARPPAARSQ QHPSVPRRMT PGRAPEQQPP PPVATSQHHP GPQSRDAGRS PSQPRLSLTQ 900
35 AGRPRPTSQG RSHSSSDPYT ASSRGMLPTA LQNQDEDAQG SYDDDSTEVE AQDVRAPAHA 960
ARAKEAAASL PKHQQVESPT GAGAGGDHRS QRGHAASPAR PSRPGGPQSR ARVPSRAAPG 1020
KSEPPSKRPL SSKSQQSVSA EDEEEEDAGF FKGGKEDLLS SSVPKWPSSS TPRGGKDADG 1080
SLAKEEREPA IALAPRGGΞL APVKRPLPPP PGSSPRASHV PSRPPPRSAA TVSPVAGTHP 1140
WPRYTTRAPP GHFSTTPMLS LRQRMMHARF RNPLΞRQPAR PSYRQGYNGR PNVEGKVLPG 1200
40 SNGKPNGQRI INGPQGTKWV VDLDRGLVLN AEGRYLQDSH GNPLRIKLGG DGRTIVDLEG 1260
TPWSPDGLP LFGQGRHGTP LANAQDKPIL SLGGKPLVGL EVIKKTTHPP TTTMQPTTTT 1320
TPLPTTTTPR PTTATTMQPT TTTTPLPTTT PRPTTATTRR TTTRRPTTTV RTTTRTTTTT 1380
TPKPTTPIPT CPPGTLERHD DDGNLIMSSN GIPECYAEED EFSGLETDTA VPTEEAYVIY 1440
DEDYEFETSR PPTTTEPSTT ATTPRVIPEE GAISSFPEEE FDLAGRKRFV APYVTYLNKD 1500
45 PSAPCSLTDA LDHFQVDSLD EIIPNDLKKS DLPPQHAPRN ITWAVEGCH SFVIVDWDKA 1560
TPGDLVTGYL VYSASYEDFI RNKFSTQASS VTHLPIENLK PNTRYYFKVQ AQNPHGYGPI 1620 SPSVSFVTES DNPLLWRPP GGELSGSHSL SNMIPATRTA MDGNM
Seq ID NO 205 Protein Sequence
50 Protein Accession II NP_055059
1 11 21 31 41 51
I I I I I I
MDPPAGAARR LLCPALLLLL LLLPPPLLPP PPPPANARLA AAADPPGGPL GHGAERILAV 60
PVRTDAQGRL VSHWSAATS RAGVRARRAA PVRTPSFPGG NEEEPGSHLF YNVTVFGRDL 120
55 HLRLRPNARL VAPGATMEWQ GEKGTTRVEP L GSCLYVGD VAGLAEASSV ALSNCDGLAG 180
LIRMEEEEFF IEPLEKGLAA QEAEQGRVHV VYRRPPTSPP LGGPQALDTG ASLDSLDSLS 240
RALGVLEEHA NSSRRRARRH AADDDYNIEV LLGVDDSWQ FHGKEHVQKY LLTLMNIVNE 300
IYHDEΞLGAH INWLVRIIL LSYGKSMSLI EIGNPSQSLE NVCRWAYLQQ KPDTGHDEYH 360
DHAIFLTRQD FGPSGMQGYA PVTGMCHPVR SCTLNHEDGF SSAFWAHET GHVLGMEHDG 420
60 QGNRCGDEVR LGSIMAPLVQ AAFHRFHWSR CSQQELSRYL HSYDCLLDDP FAHDWPALPQ 480
LPGLHYSMNE QCRFDFGLGY MMCTAFRTFD PCKQLWCSHP DNPYFCKTKK GPPLDGTMCA 540
PGKHCFKGHC IWLTPDILKR DGSWGAWSPF GSCSRTCGTG VKFRTRQCDN PHPANGGRTC 600
SGLAYDFQLC SRQDCPDSLA DFREEQCRQW DLYFEHGDAQ HHWLPHEHRD AKERCHLYCE 660
SRETGEWSM KRMVHDGTRC SYKDAFSLCV RGDCRKVGCD GVIGSSKQED KCGVCGCDNS 720
65 HCKWKGTFT RSPKKHGYIK MFEIPAGARH LLIQEVDATS HHLAVKNLET GKFILNEEND 780
VDASSKTFIA MGVEWEYRDE DGRETLQTMG PLHGTITVLV IPVGDTRVSL TYKYMIHEDS 840
LNVDDNNVLE EDSWYEWAL KKWSPCSKPC GGGΞQFTKYG CRRRLDHKMV HRGFCAALSK 900
PKAIRRACNP QECSQPVWVT GEWEPCSQTC GRTGMQVRSV RCIQPLHDNT TRSVHAKHCN 960
DARPESRRAC SRELCPGRWR AGPWSQCSVT CGNGTQERPV PCRTADDSFG ICQEERPETA 1020
70 RTCRLGPCPR NISDPSKKSY WQWLSRPDP DSPIRKISSK GHCQGDKSIF CRMEVLSRYC 1080
SIPGYNKLSC KSCNLYNNLT NVEGRIEPPP GKHNDIDVFM PTLPVPTVAM EVRPSPSTPL 1140
EVPLNASSTN ATEDHPETNA VDEPYKIHGL EDEVQPPNLI PRRPSPYEKT RNQRIQELID 1200
EMRKKEMLGK F 1211
75 Seq ID NO 206 Protein sequence
Protein Accession It NP_076927
1 11 21 31 41 51
I I I I I I
MGENDPPAVE APFSFRSLFG LDDLKISPVA PDADAVAAQI LSLLPLKFFP IIVIGIIALI 60
80 LALAIGLGIH FDCSGKYRCR SSFKCIELIA RCDGVSDCKD GEDEYRCVRV GGQNAVLQVF 120
TAASWKTMCS DDWKGHYANV ACAQLGFPSY VSSDNLRVSS LEGQFREEFV SIDHLLPDDK 180
VTALHHSVYV REGCASGHW TLQCTACGHR RGYSSRIVGG NMSLLSQWPW QASLQFQGYH 240
LCGGSVITPL WIITAAHCVY DLYLPKSWTI QVGLVSLLDN PAPSHLVEKI VYHSKYKPKR 300
LGNDIALMKL AGPLTFNEMI QPVCLPNSEE NFPDGKVCWT SGWGATEDGG DASPVLNHAA 360 VPLISNKICN HRDVYGGIIS PSMLCAGYLT GGVDSCQGDS GGPLVCQERR LWKLVGATSF 420 GIGCAEVNKP GVYTRVTSFL DWIHEQMERD LKT
Seq ID NO. 207 Protein Sequence 5 Protein Accession H -. CAC03433.2
1 11 21 31 41 51
I I I I I I
MLSSTDFTFA SWELWRVDH PNEEQQKDVT LRVSGDLHVG GVMLKLVEQI NISQDWSDFA 60
LWWEQKHCWL LKTHWTLDKY GVQADAKLLF TPQHKMLRLR LPNLKMVRLR VSFSAWFKA 120 0 VSDICKILNI RRSEELSLLK PSGDYFKKKK KKDKNNKEPI IEDILNLESS PTASGSSVSP 180
GLYSKTMTPI YDPINGTPAS STMTWFSDSP LTEQNCSILA FSQPPQSPEA LADMYQPRSL 240
VDKAKLNAGW LDSSRSLMEQ GIQEDEQLLL RFKYYSFFDL NPKYDAVRIN QLYEQARWAI 300
LLEEIDCTEE EMLIFAALQY HISKLSLSAE TQDFAGESEV DEIEAALSNL EVTLEGGKAD 360
SLLEDITDIP KLADNLKLFR PKKLLPKAFK QYWFIFKDTS IAYFKNKELE QGEPLEKLNL 420
15 RGCEWPDVN VAGRKFGIKL LIPVADGMNE MYLRCDHENQ YAQWMAACML ASKGKTMADS 480
SYQPEVLNIL SFLRMKNRNS ASQVASSLEN MDMNPECFVS PRCAKKHKSK Q AARILEAH 540
QNVAQMPLVE AKLRFIQAWQ SLPEFGLTYY LVRFKGSKKD DILGVSYNRL IKIDAATGIP 600
VTTWRFTNIK QWNVNWETRQ WIEFDQNVF TAFTCLSADC KIVHEYIGGY IFLSTRSKDQ 660
NETLDEDLFH KLTGGQD 677 0
Seq ID NO: 208 Protein Sequence
Protein Accession ft: NP_114433.1
1 11 21 31 41 51 5 I I I I I I
MASRSMRLLL LLSCLAKTGV LGDIIMRPSC APGWFYHKSN CYGYFRKLRN WSDAELECQS 60
YGNGAHLASI LSLKEASTIA EYISGYQRSQ PIWIGLHDPQ KRQQWQWIDG AMYLYRSWSG 120
KSMGGNKHCA EMSSNNNFLT WSSNECNKRQ HFLCKYRP 158
Seq ID NO: 209 Protein Sequence 0 Protein Accession It ■ XP_051860.2
1 11 21 31 41 51
I I I I I I
MGAAGRQDFL FKAMLTISWL TLTCFPGATS TVAAGCPDQS PELQPWNPGH DQDHHVHIGQ 60
GKTLLLTSSA TVYSIHISEG GKLVIKDHDE PIVLRTRHIL IDNGGELHAG SALCPFQGNF 120 5 TIILYGRADE GIQPDPYYGL KYIGVGKGGA LELHGQKKLS WTFLNKTLHP GGMAEGGYFF 180
ERSWGHRGVI VHVIDPKSGT VIHSDRFDTY RSKKESERLV QYLNAVPDGR ILSVAVNDEG 240
SRNLDDMARK AMTKLGSKHF LHLGFRHPWS FLTVKGNPSS SVEDHIEYHG HRGSAAARVF 300
KLFQTEHGEY FNVSLSSEWV QDVEWTEWFD HDKVSQTKGG EKISDLWKAH PGKICNRPID 360
IQATTMDGVN LSTEWYKKG QDYRFACYDR GRACRSYRVR FLCGKPVRPK LTVTIDTNVN 420 0 STILNLEDNV QSWKPGDTLV IASTDYSMYQ AEEFQVLPCR SCAPNQVKVA GKPMYLHIGE 480
EIDGVDMRAE VGLLSRNIIV MGEMEDKCYP YRNHICNFFD FDTFGGHIKF ALGFKAAHLE 540
GTELKHMGQQ LVGQYPIHFH LAGDVDERGG YDPPTYIRDL SIHHTFSRCV TVHGSNGLLI 600
KDWGYNSLG HCFFTEDGPE ERNTFDHCLG LLVKSGTLLP SDRDSKMCKM ITEDSYPGYI 660
PKPRQDCNAV STFWMANPNN NLINCAAAGS EETGFWFIFH HVPTGPSVGM YSPGYSEHIP 720
45 LGKFYNNRAH SNYRAGMIID NGVKTTEASA KDKRPFLSII SARYSPHQDA DPLKPREPAI 780
IRHFIAYKNQ DHGAWLRGGD VWLDSCRFAD NGIGLTLASG GTFPYDDGSK QEIKNSLFVG 840
ESGNVGTEMM DNRIWGPGGL DHSGRTLPIG QNFPIRGIQL YDGPINIQNC TFRKFVALEG 900
RHTSALAFRL NNAWQSCPHN NVTGIAFEDV PITSRVFFGE PGPWFNQLDM DGDKTSVFHD 960
VDGSVSEYPG SYLTKNDNWL VRHPDCINVP DWRGAICSGC YAQMYIQAYK TSNLRMKIIK 1020
50 NDFPSHPLYL EGALTRSTHY QQYQPWTLQ KGYTIHWDQT APAELAIWLI NFNKGDWIRV 1080
GLCYPRGTTF SILSDVHNRL LKQTSKTGVF VRTLQMDKVE QSYPGRSHYY WDEDSGLLFL 1140
KLKAQNEREK FAFCSMKGCE RIKIKALIPK NAGVSDCTAT AYPKFTERAV VDVPMPKKLF 1200
GSQLKTKDHF LEVKMESSKQ HFFHLWNDFA YIEVDGKKYP SSEDGIQVW IDGNQGRWS 1260
HTSFRNSILQ GIPWQLFNYV ATIPDNSIVL MASKGRYVSR GPWTRVLEKL GADRGLKLKE 1320
55 QMAFVGFKGS FRPIWVTLDT EDHKAKIFQV VPIPWKKKK L 1361
Seq ID NO. 210 Protein Sequence Protein Accession It: NP_036244.1 ,Λ 1 11 21 31 41 51
60 i i i i i i
MSQVKSSYSY DAPSDFINFS SLDDEGDTQN IDSWFEEKAN LENKLLGKNG TGGLFQGKTP 60
LRKANLQQAI VTPLKPVDNT YYKEAEKENL VEQSIPSNAC SSLEVEAAIS RKTPAQPQRR 120
SLRLSAQKDL EQKEKHHVKM KAKRCATPVI IDEILPSKKM KVSNNKKKPE EEGSAHQDTA 180
EKNASSPEKA KGRHTVPCMP PAKQKFLKST EEQELEKSMK MQQEWEMRK KNEEFKKLAL 240
65 AGIGQPVKKS VSQVTKSVDF HFRTDERIKQ HPKNQEEYKE VNFTSELRKH PSSPARVTKG 300
CTIVKPFNLS QGKKRTFDET VSTYVPLAQQ VEDFHKRTPN RYHLRSKKDD INLLPSKSSV 360
TKICRDPQTP VLQTKHRARA VTCKSTAELE AEELEKLQQY KFKARELDPR ILEGGPILPK 420
KPPVKPPTEP IGFDLEIEKR IQERESKKKT EDEHFEFHSR PCPTKILEDV VGVPEKKVLP 480
ITVPKSPAFA LKNRIRMPTK EDEEEDEPW IKAQPVPHYG VPFKPQIPEA RTVEICPFSF 540
70 DSRDKERQLQ KEKKIKELQK GEVPKFKALP LPHFDTINLP EKKVKNVTQI EPFCLETDRR 600
GALKAQTWKH QLEEELRQQK EAACFKARPN TVISQEPFVP KKEKKSVAEG LSGSLVQEPF 660
QLATEKRAKE RQELEKRMAE VEAQKAQQLE EARLQEEEQK KEELARLRRE LVHKANPIRK 720
YQGLEIKSSD QPLTVPVSPK FSTRFHC 747
75 Seq ID NO: 211 Protein Sequence
Protein Accession It : NP_065169.1
1 11 21 31 41 51
I I I I I I
MSRRKQAKPQ HINSEEDQGE QQPQQQTPEF ADAAPAAPAA GELGAPVNHP GNDEVASEDE 60
80. ATVKRLRREE THVCEKCCAE FFSISEFLEH KKNCTKNPPV LIMNDSEGPV PSEDFSGAVL 120
SHQPTSPGSK DCHRENGGSS EDMKEKPDAE SWYLKTETA LPPTPQDISY LAKGKVANTN 180
VTLQALRGTK VAVNQRSADA LPAPVPGANS IPWVLEQILC LQQQQLQQIQ LTEQIRIQVN 240
MWASHALHSS GAGADTLKTL GSHMSQQVSA AVALLSQKAG SQGLSLDALK QAKLPHANIP 300
SATSSLSPGL APFTLKPDGT RVLPNVMSRL PSALLPQAPG SVLFQSPFST VALDTSKKGK 360 GKPPNISAVD VKPKDEAALY KHKCKYCSKV FGTDSSLQIH LRSHTGERPF VCSVCGHRFT 420
TKGNLKVHFH RHPQVKANPQ LFAEFQDKVA AGNGIPYALS VPDPIDEPSL SLDSKPVLVT 480
TSVGLPQNLS SGTNPKDLTG GSLPGDLQPG PSPESEGGPT LPGVGPNYNS PRAGGFQGSG 540
TPEPGSETLK LQQLVENIDK ATTDPNECLI CHRVLSCQSS LKMHYRTHTG ERPFQCKICG 600
RAFSTKGNLK THLGVHRTNT SIKTQHSCPI CQKKFTNAVM LQQHIRMHMG GQIPNTPLPE 660
NPCDFTGSEP MTVGENGSTG AICHDDVIES IDVEEVSSQE APSSSSKVPT PLPSIHSASP 720
TLGFAMMASL DAPGKVGPAP FNLQRQGSRE NGSVESDGLT NDSSSLMGDQ EYQSRSPDIL 780
ETTSFQALSP ANSQAESIKS KSPDAGSKAE SSENSRTEME GRSSLPSTFI RAPPTYVKVE 840
VPGTFVGPST LSPGMTPLLA AQPRRQAKQH GCTRCGKNFS SASALQIHER THTGEKPFVC 900
NICGRAFTTK GNLKVHYMTH GANNNSARRG RKLAIENTMA LLGTDGKRVS EIFPKEILAP 960
SVNVDPWWN QYTSMLNGGL AVKTNEISVI QSGGVPTLPV SLGATSWNN ATVSKMDGSQ 1020
SGISADVEKP SATDGVPKHQ FPHFLEENKI AVS 1053
Seq ID NO: 212 Protein Sequence
Protein Accession It: NP_005092
1 11 21 31 41 51
I I I I I I
MGWDLTVKML AGNEFQVSLS SSMSVSELKA QITQKIGVHA FQQRLAVHPS GVALQDRVPL 60
ASQGLGPGST VLLWDKCDE PLSILVRNNK GRSSTYEVRL TQTVAHLKQQ VSGLEGVQDD 120
LFWLTFEGKP LEDQLPLGEY GLKPLSTVFM NLRLRGGGTE PGGRS 165
Seq ID NO: 213 Protein sequence
Protein Accession (f: Eos sequence
1 11 21 31 41 51 i i i i i i
MIILIYLFLL L EDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT YAEAKAVCEF 60
EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG PNCGFGKTGI IDYGIRLNRS 120
ERWDAYCYNP HAKECGGVFT DPKQIFKSPG FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF 180
DLEDDPGCLA DYVEIYDSYD DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF 240 QIKYVAMDPV SKSSQGKNTS TTSTGNKNFL AGRFSHL
Seq ID NO: 214 Protein sequence
Protein Accession tt : NP_009046.1
1 11 21 31
MIILIYLFLL LWEDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT YAEAKAVCEF 60
EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG PNXXFGKTGI IDYGIRLNRS 120
ERWDAYCYNP HAKECGGVFT DPKRIFKSPG FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF 180
DLEDDPGCLA DYVEIYDSYD DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF 240 QIKYVAMDPV SKSSQGKNTS TTSTGNKNFL AGRFSHL
Seq ID NO: 215 Protein Sequence
Protein Accession It: NP_006389.1
1 11 21 31 41 51 i i i i i i
MAPNASCLCV HVRSEEWDLM TFDANPYDSV KKIKEHVRSK TKVPVQDQVL LLGSKILKPR 60 RSLSSYGIDK EKTIHLTLKV VKPSDEELPL FLVESGDEAK RHLLQVRRSS SVAQVKAMIE 120 TKTGIIPETQ IVTCNGKRLE DGKMMADYGI RKGNLLFLAS YCICC 165
Seq ID NO: 216 Protein Sequence
Protein Accession - NP_002349.1
1 11 21 31 41 51
I I I I I I
MALQLSREQG ITLRGSAEIV AEFFSFGINS ILYQRGIYPS ETFTRVQKYG LTLLVTTDLE 60
LIKYLNNWE QLKDWLYKCS VQKLVWISN IESGEVLERW QFDIECDKTA KDDSAPREKS 120
QKAIQDEIRS VIRQITATVT FLPLLEVSCS FDLLIYTDKD LWPEKWEES GPQFITNSEE 180
VRLRSFTTTI HKVNSMVAYK IPVND 205
Seq ID NO: 217 Protein sequence
PrOtein Accession It: NP_001889.1
1 11 21 31 41 51
I I I I I I
MAQYLSTLLL LLATLAVALA WSPKEEDRII PGGIYNADLN DEWVQRALHF AISEYNKATK 60 DDYYRRPLRV LRARQQTVGG VNYFFDVEVG RTICTKSQPN LDTCAFHEQP ELQKKQLCSF 120 EIYEVPWENR RSLVKSRCQE S
Seq ID NO: 218 Protein sequence
Protein Accession It: NP_009162.1
1 11 21 31 41 51 i i i i i i
MDKLKCPSFF KCREKEKVSA SSENFHVGEN DENQDRGNWS KKSDYLLSMI GYAVGLGNVW 60
RFPYLTYSNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA SLGPVSVWRI LPLFQGVGIT 120
MVLISIFVTI YYNVIIAYSL YYMFASFQSE LPWKNCSSWS DKNCSRSPIV THCNVSTVNK 180
GIQEIIQMNK SWVDINNFTC INGSEIYQPG QLPSEQYWNK VALQRSSGMN ETGVIVWYLA 240
LCLLLAWLIV GAALFKGIKS SGKWYFTAL FPYWLLILL VRGATLEGAS KGISYYIGAQ 300
SNFTKLKEAE VWKDAATQIF YSLSVAWGGL VALSSYNKFK NNCFSDAIW CLTNCLTSVF 360
AGFAIFSILG HMAHISGKEV SQWKSGFDL AFIAYPEALA QLPGGPFWSI LFFFMLLTLG 420
LDSQFASIET ITTTIQDLFP KVMKKMRVPI TLGCCLVLFL LGLVCVTQAG IYWVHLIDHF 480
CAGWGILIAA ILELVGIIWI YGGNRFIEDT EMMIGAKRWI FWLWWRACWF VITPILLIAI 540
FIWSLVQFHR PNYGAIPYPD WGVALGWCMI VFCIIWIPIM AIIKIIQAKG NIFQRLISCC 600 RPASNWGPYL EQHRGERYKD MVDPKKEADH EIPTVSGSRK PE
Seq ID NO: 219 Protein sequence Protein Accession #: NP 006389.1 1 11 21 31 41 51
I I I I I I
MAPNASCLCV HVRSEEWDLM TFDANPYDSV KKIKEHVRSK TKVPVQDQVL LLGSKILKPR 60
RSLSSYGIDK EKTIHLTLKV VKPSDEELPL FLVESGDEAK RHLLQVRRSS SVAQVKAMIE 120 5 TKTGIIPETQ IVTCNGKRLE DGKMMADYGI RKGNLLFLAS YCIGG
Seq ID NO 220 Protein sequence Protein Accession tt XP_09474i 1 , - 1 11 21 31 41 51
10 i i i i i i
MKANYSAEER FLLLGFSDWP SLQPVLFALV LLCYLLTLTG NSALVLLAVR DPRLHTPMYY 60
FLCHLALVDA GFTTS PPL LANLRGPALW LPRSHCTAQL CASLALGSAE CVLLAVMALD 120
RAAAVCRPLR YAGLVSPRLC RTLASASWLS GLTNSVAQTA LLAERPLCAP RLLDHFICEL 180
PALLKLACGG DGDTTENQMF AARWILLLP FAVILASYGA VARAVCCMRF SGGRRRAVGT 240
15 CGSHLTAVCL FYGSAIYTYL QPAQRYNQAR GKFVSLFYTV VTPALNPLIY TLRNKKVKGA 300 ARRLLRSLGR GQAGQ
Seq ID NO 221 Protein Sequence 20 Protein Accession It NP_06115S 1
1 11 21 31 41 51
I I I I I I
MDPFTEKLLE RTRARRENLQ RKMAERPTAA PRSMTHAKRA RQPLSEASNQ QPLSGGEEKS 60
CTKPSPSKKR CSDNTEVEVS NLENKQPVES TSAKSCSPSP VSPQVQPQAA DTISDSVAVP 120
25 ASLLGMRRGL NSRLEATAAS SVKTRMQKLA EQRRRWDNDD MTDDIPESSL FSPMPSEEKA 180
ASPPKPLLSN ASATPVGRRG RLANLAATIC SWEDDVNHSF AKQNSVQEQP GTACLSKFSS 240
ASGASARINS SSVKQEATFC SQRDGDASLN KALSSSADDA SLVNASISSS VKATSPVKST 300
TSITDAKSCE GQNPELLPKT PISPLKTGVS KPIVKSTLSQ TVPSKGELSR EICLQSQSKD 360
KSTTPGGTGI KPFLERFGER CQEHSKESPA RSTPHRTPII TPNTKAIQER LFKQDTSSST 420
30 THLAQQLKQE RQKELACLRG RFDKGNIWSA EKGGNSKSKQ LETKQETHCQ STPLKKHQGV 480
SKTQSLPVTE KVTENQIPAK NSSTEPKGFT ECEMTKSSPL KITLFLEEDK SLKVTSDPKV 540
EQKIEVIREI EMSVDDDDIN SSKVINDLFS DVLEEGELDM EKSQEEMDQA LAESSEEQED 600
ALNISSMSLL APLAQTVGW SPESLVSTPR LELKDTSRSD ESPKPGKFQR TRVPRAESGD 660
SLGSEDRDLL YSIDAYRSQR FKETERPSIK QVIVRKEDVT SKLDEKNNAF PCQVNIKQKM 720
35 QELNNEINMQ QTVIYQASQA LNCCVDEEHG KGSLEEAEAE RLLLIATGKR TLLIDELNKL 780
KNEGPQRKNK ASPQSEFMPS KGSVTLSEIR LPLKADFVCS TVQKPDAANY YYLIILKAGA 840
ENMVATPLAS TSNSLNGDAL TFTTTFTLQD VSNDFEINIE VYSLVQKKDP SGLDKKKKTS 900
KSKAITPKRL LTSITTKSNI HSSVMASPGG LSAVRTSNFA LVGSYTLSLS SVGNTKFVLD 960
KVPFLSSLEG HIYLKIKCQV NSSVEERGFL TIFEDVSGFG AWHRRWCVLS GNCISYWTYP 1020
40 DDEKRKNPIG RINLANCTSR QIEPANREFC ARRNTFELIT VRPQREDDRE TLVSQCRDTL 1080
CVTKNWLSAD TKEERDLWMQ KLNQVLVDIR LWQPDACYKP IGKP 1124
Seq ID NO 222 Protein Sequence
Protein Accession II Q9H8V3
45 1 11 21 31 41 51
I I I I I I
MAENSVLTST TGRTSLADSS IFDSKVTEIS KENLLIGSTS YVEEEMPQIE TRVILVQEAG 60
KQEELTKALK DIKVGFVKME SVEEFEGLDS PEFENVFWT DFQDSVFNDL YKADCRVIGP 120
PWLNCSQKG EPLPFSCRPL YCTSMMNLVL CFTGFRKKEE LVRLVTLVHH MGGVIRKDFN 180
50 SKVTHLVANC TQGEKFRVAV SLGTPIMKPE WIYKAWERRN EQDFYAAVDD FRNEFKVPPF 240
QDCIFSFLGF SDEEKTNMEE MTEMQGGKYL PLGDERCTHL WEENIVKDL PFEPSKKLYV 300
VKQEWFWGSI QMDARAGETM YLYEKANTPE LKKSVSMLSL NTPNSNRKRR RLKETLAQLS 360
RDTDVSPFPP RKRPSAEHSL SIGSLLDISN TPESSINYGD TPKSCTKSSK SSTPVPSKQS 420
ARWQVAKELY QTESNYVNIL ATIIQLFQVP LEEEGQRGGP ILAPEEIKTI FGSIPDIFDV 480
55 HTKIKDDLED LIVNWDESKS IGDIFLKYSK DLVKTYPPFV NFFEMSKETI IKCEKQKPRF 540
HAFLKINQAK PECGRQSLVE LLIRPVQRLP SVALLI-NDLK KHTADENPDK STLEKAIGSL 600
KEVMTHINED KRKTEAQKQI FDWYEVDGC PANLLSSHRS LVQRVETISL GEHPCDRGEQ 660
VTLFLFNDCL EIARKRHKVI GTFRSPHGQT RPPASLKHIH LMPLSQIKKV LDIRETEDCH 720
NAFALLVRPP TEQANVLLSF QMTSDELPKE NWLKMLCRHV ANTICKADAE NLIYTADPES 780
60 FEVNTKDMDS TLSRASRAIK KTSKKVTRAF SFSKTPKRAL RRALMTSHGS VEGRSPSSND 840
KHVMSRLSST SSLAGIPSPS LVSLPSFFER RSHTLSRSTT HLI 883
Seq ID NO 223 Protein Sequence
Protein Accession It NP_002488 1
65 1 11 21 31 41 51
I I I I I I
MPSRAEDYEV LYTIGTGSYG RCQKIRRKSD GKILVWKELD YGSMTEAEKQ MLVSEVNLLR 60
ELKHPNIVRY YDRIIDRTNT TLYIVMEYCE GGDLASVITK GTKERQYLDE EFVLRVMTQL 120
TLALKECHRR SDGGHTVLHR DLKPANVFLD GKQNVKLGDF GLARILNHDT SFAKTFVGTP 180
70 YYMSPEQMNR MSYNEKSDIW SLGCLLYELC ALMPPFTAFS QKELAGKIRE GKFRRIPYRY 240
SDELNEIITR MLNLKDYHRP SVEEILENPL IADLVADEQR RNLERRGRQL GEPEKSQDSS 300
PVLSELKLKE IQLQERERAL KAREERLEQK EQELCVRERL AEDKLARAEN LLKNYSLLKE 360
RKFLSLASNP ELLNLPSSVI KKKVHFΞGES KENIMRSENS ESQLTSKSKC KDLKKRLHAA 420
QLRAQALSDI EKNYQLKSRQ ILGMR 445
75
Seq ID NO 224 Protein Sequence
Protein Accession tt Eos sequence
1 11 21 31 41 51
80 I I I I I I
DISYENENYN SSWIPGSHIV SPSLLLNLNN GQLLPLQLQG PLNSWIPPFS GILQQQQQAQ 60
IPGLSQFSLS ALDQFAGLLP NQIPLTGEAS FAQGAQAGQV DPLQLQTPPQ TQPGPSHVMP 120
YVFSFKMPQE QGQMFQYYPV YMVLPWEQPQ QTVPRSPQQT RQQQYEEQIP FYAQFGYIPQ 180
LAEPAISGGQ QQLAFDPQLG TAPEIAVMST GEEIPYLQKE AINFRHDSAG VFMPSTSPKP 240
STTNVFTSAV DQTITPELPE EKDKTDSLRE P 271 Seq ID NO 225 Protein Sequence Protein Accession If eos sequence
1 11 21 31 41 51 I I I I I I
RGKEHRSRMV QIFLFRSRSK IYHTKMKIII LLGFLGATLS APLIPQRLMS ASNSNELLLN 60 LNNGQLLPLQ LQGPLNSWIP PFSGILQQQQ QAQIPGLSQF SLSALDQFAG LLPNQIPLTG 120 EASFAQGAQA GQVDPLQLQT PPQTQPGPSH VMPYVFSFKM PQEQGQMFQY YPVYMVLPWE 180 QPQQTVPRSP QQTRQQQYEE QIPFYAQFGY IPQLAEPAIS GGQQQLAFDP QLGTAPEIAV 240 MSTGEEIPYL QKEAINFRHD SAGVFMPSTS PKPSTTNVFT SAVDQTITPE LPEEKDKTDS 300 LREP 304
Seq ID NO 226 Protein Sequence Protein Accession tt NP_003970 1 1 11 21 31 41 51
I I I I I I
MATTVPDGCR NGLKSKYYRL CDKAEAWGIV LETVATAGW TSVAFMLTLP ILVCKVQDSN 60
RRKMLPTQFL FLLGVLGIFG LTFAFIIGLD GSTGPTRFFL FGILFSICFS CLLAHAVSLT 120
KLVRGRKPLS LLVILGLAVG FSLVQDVIAI EYIVLTMNRT NVNVFSELSA PRRNEDFVLL 180 LTYVLFLMAL TFLMSSFTFC GSFTGWKRHG AHIYLTMLLS IAIWVAWITL LMLPDFDRRW 240
DDTILSSALA ANGWVFLLAY VSPEFWLLTK QRNPMDYPVE DAFCKPQLVK KSYGVENRAY 300
SQEEITQGFE ETGDTLYAPY STHFQLQNQP PQKEFSIPRA HAWPSPYKDY EVKKEGS 357
Seq ID NO 227 Protein Sequence
Protein Accession # NP_11657S 1
1 11 21 31 41 51
I I I I I I
MPKIVLNGVT VDFPFQPYKC QQEYMTKVLE CLQQKVNGIL ESPTGTGKTL CLLCTTLAWR 60
EHLRDGISAR KIAERAQGEL FPDRALSSWG NAAAAAGDPI ACYTDIPKII YASRTHSQLT 120
QVINELRNTS YRPKVCVLGS REQLCIHPEV KKQESNHLQI HLCRKKVASR SCHFYNNVEE 180
KSLEQELASP ILDIEDLVKS GSKHRVCPYY LSRNLKQQAD IIFMPYNYLL DAKSRRAHNI 240
DLKGTWIFD EAHNVEKMCE ESASFDLTPH DLASGLDVID QVLEEQTKAA QQGEPHPEFS 300
ADSPSPGLNM ELEDIAKLKM ILLRLEGAID AVELPGDDSG VTKPGSYIFE LFAEAQITFQ 360
TKGCILDSLD QIIQHLAGRA GVFTNTAGLQ KLADIIQIVF SVDPSEGSPG SPAGLGALQS 420 YKVHIHPDAG HRRTAQRSDA WSTTAARKRG KVLSYWCFSP GHSMHELVRQ GVRSLILTSG 480
TLAPVSSFAL EMQIPFPVCL ENPHIIDKHQ IWVG PRGP DGAQLSSAFD RRFSEECLSS 540
LGKALGNIAR PYGLLIFF PSYPVMEKSL EFWRARDLAR KMEALKPLFV EPRSKGSFSE 600
TISAYYARVA APGSTGATFL AVCRGKASEG LDFSDTNGRG VIVTGLPYPP RMDPR LKM 660
QFLDEMKGQG GAGGQFLSGQ EWYRQQASRA VNQAIGRVIR HRQDYGAVFL CDHRFAFADA 720
RAQLPSWVRP HVRVYDNFGH VIRDVAQFFR VAERTMPAPA PRATAPSVRG EDAVSEAKSP 780
GPFFSTRKAK SLDLHVPSLK QRSSGSPAAG DPESSLCVEY EQEPVPARQR PRGLLAALEH 840
SEQRAGSPGE EQAHSCSTLS LLSEKRPAEE PRGGRKKIRL VSHPEEPVAG AQTDRAKLFM 900
VAVKQELSQA NFATFTQALQ DYKGSDDFAA LAACLGPLFA EDPKKHNLLQ GFYQFVRPHH 960
KQQFEEVCIQ LTGRGCGYRP EHSIPRRQRA QPVLDPTGRT APDPKLTVST AAAQQLDPQE 1020
HLNQGRPHLS PRPPPTGDPG SQPQWGSGVP RAGKQGQHAV SAYLADARRA LGSAGCSQLL 1080
AALTAYKQDD DLDKVLAVLA ALTTAKPEDF PLLHRFSMFV RPHHKQRFSQ TCTDLTGRPY 1140
PGMEPPGPQE ERLAVPPVLT HRAPQPGPSR SEKTGKTQSK ISSFLRQRPA GTVGAGGEDA 1200
GPSQSSGPPH GPAASEWGEP HGRDIAGQQA TGAPGGPLSA GCVCQGCGAE DWPFQCPAC 1260
DFQRCQACWQ RHLQASRMCP ACHTASRKQS VMQVFWPEPH KDHEGAGGAR PVAAVPGVGA 1320
ACPAAGAGCT RSGRNTHLPL AGRRDRGAAG VCPVPPRHLC AAAVPPRQPH DVWPVSTAPL 1380
HAVLELPGAL PLLQRPLRGA 1400
Seq ID NO 228 Protein Sequence
Protein Accession II NP_057518 1
1 11 21 31 41 51
I I I I I I
MPKIVLNGVT VDFPFQPYKC QQEYMTKVLE CLQQKVNGIL ESPTGTGKTL CLLCTTLAWR 60
EHLRDGISAR KIAERAQGEL FPDRALSSWG NAAAAAGDPI ACYTDIPKII YASRTHSQLT 120
QVINELRNTS YRPKVCVLGS REQLCIHPEV KKQESNHLQI HLCRKKVASR SCHFYNNVEE 180
KSLEQELASP ILDIEDLVKS GSKHRVCPYY LSRNLKQQAD IIFMPYNYLL DAKSRRAHNI 240
DLKGTWIFD EAHNVEKMCE ESASFDLTPH DLASGLDVID QVLEEQTKAA QQGEPHPEFS 300
ADSPSPGLNM ELEDIAKLKM ILLRLEGAID AVELPGDDSG VTKPGSYIFE LFAEAQITFQ 360
TKGCILDSLD QIIQHLAGRA GVFTNTAGLQ KLADIIQIVF SVDPSEGSPG SPAGLGALQS 420
YKVHIHPDAG HRRTAQRSDA WSTTAARKRG KVLSYWCFSP GHSMHELVRQ GVRSLILTSG 480
TLAPVSSFAL EMQIPFPVCL ENPHIIDKHQ IWVGWPRGP DGAQLSSAFD RRFSEECLSS 540
LGKALGNIAR WPYGLLIFF PSYPVMEKSL EFWRARDLAR KMEALKPLFV EPRSKGSFSE 600
TISAYYARVA APGSTGATFL AVCRGKASEG LDFSDTNGRG VIVTGLPYPP RMDPRWLKM 660
QFLDEMKGQG GAGGQFLSGQ EWYRQQASRA VNQAIGRVIR HRQDYGAVFL CDHRFAFADA 720
RAQLPSWVRP HVRVYDNFGH VIRDVAQFFR VAERTMPAPA PRATAPSVRG EDAVSEAKSP 780
GPFFSTRKAK SLDLHVPSLK QRSSGSPAAG DPESSLCVEY EQEPVPARQR PRGLLAALEH 840
SEQRAGSPGE EQAHSCSTLS LLSEKRPAEE PRGGRKKIRL VSHPEEPVAG AQTDRAKLFM 900
VAVKQELSQA NFATFTQALQ DYKGSDDFAA LAACLGPLFA EDPKKHNLLQ GFYQFVRPHH 960
KQQFEEVCIQ LTGRGCGYRP EHSIPRRQRA QPVLDPTGRT APDPKLTVST AAAQQLDPQE 1020
HLNQGRPHLS PRPPPTGDPG SQPQWGSGVP RAGKQGQHAV SAYLADARRA LGSAGCSQLL 1080
AALTAYKQDD DLDKVLAVLA ALTTAKPEDF PLLHRFSMFV RPHHKQRFSQ TCTDLTGRPY 1140
PGMEPPGPQE ERLAVPPVLT HRAPQPGPSR SEKTGKTQSK ISSFLRQRPA GTVGAGGEDA 1200
GPSQSSGPPH GPAASEWGL 1219
Seq ID NO 229 Protein Sequence
Protein Accession It NP_056462 1
1 11 21 31 41 51
I I I I I I
MPAPAPRATA PSVRGEDAVS EAKSPGPFFS TRKAKSLDLH VPSLKQRSSG SPAAGDPESS 60
LCVEYEQEPV PARQRPRGLL AALEHSEQRA GSPGEEQAHS CSTLSLLSEK RPAEEPRGGR 120 KKIRLVSHPE EPVAGAQTDR AKLFMVAVKQ ELSQANFATF TQALQDYKGS DDFAALAACL 180
GPLFAEDPKK HNLLQGFYQF VRPHHKQQFE EVCIQLTGRG CGYRPEHSI P RRQRAQPVLD 240
PTGRTAPDPK LTVSTAAAQQ LDPQEHLNQG RPHLSPRPPP TGDPGSQPQW GSGVPRAGKQ 300
GQHAVSAYLA DARRALGSAG CSQLLAALTA YKQDDDLDKV LAVLAALTTA KPEDFPLLHR 360 FSMFVRPHHK QRFSQTCTDL TGRPYPGMEP PGPQEERLAV PPVLTHRAPQ PGPSRSEKTG 420
KTQSKI SSFL RQRPAGTVGA GGEDAGPSQS SGPPHGPAAS EWGEPHGRDI AGQQATGAPG 480
GPLSAGCVCQ GCGAEDWPF QCPACDFQRC QACWQRHLQA SRMCPACHTA SRKQSVMQVF 540
WPEPQ 545 Seq ID NO : 230 Protein Sequence
Protein Accession It : NP_003814 . 1 1 11 21 31 41 51
I I I I I I
MRALEGPGLS LLCLVLALPA LLPVPAVRGV AETPTYPWRD AETGERLVCA QCPPGTFVQR 60
PCRRDSPTTC GPCPPRHYTQ FWNYLERCRY CNVLCGEREE EARACHATHN RACRCRTGFF 120
AHAGFCLEHA SCPPGAGVIA PGTPSQNTQC QPCPPGTFSA SSSSSEQCQP HRNCTALGLA 180
LNVPGSSSHD TLCTSCTGFP LSTRVPGAEE CERAVIDFVA FQDISIKRLQ RLLQALEAPE 240
GWGPTPRAGR AALQLKLRRR LTELLGAQDG ALLVRLLQAL RVARMPGLER SVRERFLPVH 300 Seq ID NO: 231 Protein Sequence
Protein Accession It: NP_116563.1 1 11 21 31 41 51
I I I I I I
MRALEGPGLS LLCLVLALPA LLPVPAVRGV AETPTYPWRD AETGERLVCA QCPPGTFVQR 60 PCRRDSPTTC GPCPPRHYTQ FWNYLERCRY CNVLCGEREE EARACHATHN RACRCRTGFF 120
AHAGFCLEHA SCPPGAGVIA PGTPSQNTQC QPCPPGTFSA SSSSSEQCQP HRNCTALGLA 180
LNVPGSSSHD TLCTSCTGFP LSTRVPGAEE CERAVIDFVA FQDISIKRLQ RLLQALEAPE 240
GWGPTPRAGR AALQLKLRRR LTELLGAQDG ALLVRLLQAL RVARMPGLER SVRERFLPVH 300
Seq ID NO: 232 Protein Sequence
Protein Accession U -. NP_000584.2
1 11 21 31 41 51
I I I I I I
MAELLASAGS ACSWDFPRAP PSFPPPAASR GGLGGTRSFR PHRGAESPRP GRDRDGVRVP 60
MASSRCPAPR GCRCLPGASL AWLGTVLLLL ADWVLLRTAL PRIFSLLVPT ALPLLRVWAV 120
GLSRWAVLWL GACGVLRATV GSKSENAGAQ GWLAALKPLA AALGLALPGL ALFRELI SWG 180
APGSADSTRL LHWGSHPTAF SYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL 240
GSETRRLSLF LVL LSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV 300
LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNIMSRVTE DTSTLSDSLS 360 ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLITLPLLFL LPKKVGKWYQ LLEVQVRESL 420
AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF REKLQEIKTL NQKEAVAYAV NSWTTSI SGM 480
LLKVGILYIG GQLVTSGAVS SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKI FE 540
YLDRTPRCPP SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN 600
GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV FGRSLQENIA 660 YGLTQKPTME EITAAAVKSG AHSFI SGLPQ GYDTEVDEAG SQLSGGQRQA VALARALIRK 720
PCVLILDDAT SALDANSQLQ VEQLLYESPE RYSRSVLLIT QHLSLVEQAD HILFLEGGAI 780
REGGTHQQLM EKKGCYWAMV QAPADAPE 808
Seq ID NO: 233 Protein Sequence
Protein Accession It NP_002414.1
1 11 21 31 41 51
I I I I I I
MRLTVLCAVC LLPGSLALPL PQEAGGMSEL QWEQAQDYLK RFYLYDSETK NANSLEAKLK 60
EMQKFFGLPI TGMLNSRVIE IMQKPRCGVP DVAEYSLFPN SPKWTΞKWT YRIVSYTRDL 120
PHITVDRLVS KALNMWGKEI PLHFRKWWG TADIMIGFAR GAHGDSYPFD GPGNTLAHAF 180
APGTGLGGDA HFDEDERWTD GSSLGINFLY AATHELGHSL GMGHSSDPNA VMYPTYGNGD 240
PQNFKLSQDD IKGIQKLYGK RSNSRKK 267
Seq ID NO: 234 Protein Sequence
Protein Accession It- NP_061144
1 11 21 31 41 51
I I I I I I
MPIEIVCKIK FAEEDAKPKE KEAGDEQSLL GAVAPGAAPR DLATFASTST LHGLGRACGP 60
GPHGLRRTLW ALALLTSLAA FLYQAAGLAR GYLTRPHLVA MDPAAPAPVA GFPAVTLCNI 120
NRFRHSALSD ADIFHLANLT GLPPKDRDGH RAAGLRYPEP DMVDILNRTG HQLADMLKSC 180
NFSGHHCSAS NFSWYTRYG KCYTFNADPR SSLPSRACCM GSGLEIMLDI QQEEYLPIWR 240
ETNETSFEAG IRVQIHSQEE PPYIHQLGFG VSPGFQTFVS CQEQRLTYLP QPWGNCRAES 300
ELREPELQGY SAYSVSACRL RCEKEAVLQR CHCRMVHMPG NETICPPNIY IECADHTLDS 360
LGGGPEGPCF CPTPCNLTRY GKEISMVRI P NRGSARYLAR KYNRNETYIR ENFLVLDVFF 420
EALTSEAMEQ RAAYGLSALL GDLGGQMGLF IGASI LTLLE ILDYIYEVSW DRLKRVWRRP 480
KTPLRTSTGG ISTLGLQELK EQSPCPSLGR AEGGGVSSLL PNHHHPHGPP GGLFEDFAC 539
Seq ID NO : 235 Protein Sequence
Prote in Access ion It : BAC03567
1 11 21 31 41 51
I I I I I I
MEVSSPSPAQ RLRRKKRPMV QGPAGCQVFQ PSPSGGTAGD PGGLSDPFYP PRSGSLALGD 60
PSSDPACSQS GPMEAEEDSL PEQPEDSAQL QQEKPSLYIG VRGTWRSMQ EVLWTRLREL 120
PDPVLSEEW EGIAAGIEAA LWDLTQGTNG RYKTKYRSLL FNLRDPRNLD LFLKWHGDV 180
TPYDLVRMSS MQLAPQELAR WRDQEEKRGL NIIEQQQKEP CRLPASKMTH KGEVEIQRDM 240
DQTLTLEDLV GPQMFMDCSP QALPIASEDT TGQHDHHFLD PNCHICKDWE PSNELLGSFE 300
AAKSCGDNIF QKALSQTPMP APEMPKTREL SPTEPQDRVP PSGLHVPAAP TKALPCLPPW 360
EGVLDMFSIK RFRARAQLVS GHSCRLVQAL PTVIRSAGCI PSNIVWDLLA SICPAKAKDV 420
CWRLCPHGA RDTQNCRLLY SYLNDRQRHG LASVEHMGMV LLPLPAFQPL PTRLRPLGGP 480 GLEVTHSSLL LAVLLPKEGL PDTAGSSPWL GKVQKMVSFN SKVEKRYYQp DDRRPNVPLK 540
GTPPPGGAWQ QSQGRGSIAP RGISAWQRPP RGRGRLWPEP ENWQHPGRGQ WPPEPGLRQS 600
QHPYSVAPAG HGFGRGQHFH RDSCPHQALL RHLESLATMS HQLQALLCPQ TKSSIPRPLQ 660
RLSSALAAPE PPGPARDSSL GPTDEAGSEC PFPRKA 696
Seq ID NO 236 Protein Sequence
Protein Accession II NP_005282
1 11 21 31 41 51
I I I I I I
MSKRSWWAGS RKPPREMLKL SGSDSSQSMN GLEVAPPGLI TNFSLATAEQ CGQETPLENM 60
LFASFYLLDF ILALVGNTLA LWLFIRDHKS GTPANVFLMH LAVADLSCVL VLPTRLVYHF 120
SGNHWPFGEI ACRLTGFLFY LNMYASIYFL TCISADRFLA IVHPVKSLKL RRPLYAHLAC 180
AFLWVWAVA MAPLLVSPQT VQTNHTWCL QLYREKASHH ALVSLAVAFT FPFITTVTCY 240
LLIIRSLRQG LRVEKRLKTK AVRMIAIVLA IFLVCFVPYH VNRSVYVLHY RSHGASCATQ 300
RILALANRIT SCLTSLNGAL DPIMYFFVAE KFRHALCNLL CGKRLKGPPP SFEGKTNESS 360
LSAKSEL 367
Seq ID NO 237 Protein Sequence
Protein Accession II NP_061113
1 11 21 31 41 51
I I I I I I
MRKTRLWGLL WMLFVSELRA ATKLTEEKYE LKEGQTLDVK CDYTLEKFAS SQKAWQIIRD 60
GEMPKTLACT ERPSKNSHPV QVGRIILEDY HDHGLLRVRM VNLQVEDSGL YQCVIYQPPK 120
EPHMLFDRIR LWTKGFSGT PGSNENSTQN VYKIPPTTTK ALCPLYTSPR TVTQAPPKST 180
ADVSTPDSEI NLTNVTDIIR VPVFNIVILL AGGFLSKSLV FSVLFAVTLR SFVP 234
Seq ID NO 238 Protein Sequence
Protein Accession tt NP_003458
1 11 21 31 41 51 I I I I I I
MEGISIYTSD NYTEEMGSGD YDSMKEPCFR EENANFNKIF LPTIYSIIFL TGIVGNGLVI 60
LVMGYQKKLR SMTDKYRLHL SVADLLFVIT LPFWAVDAVA NWYFGNFLCK AVHVIYTVNL 120
YSSVLILAFI SLDRYLAIVH ATNSQRPRKL LAEK YVGV WIPALLLTIP DFIFANVSEA 180
DDRYICDRFY PNDLWVWFQ FQHIMVGLIL PGIVILSCYC IIISKLSHSK GHQKRKALKT 240 TVILILAFFA CWLPYYIGIS IDSFILLEII KQGCEFENTV HKWISITEAL AFFHCCLNPI 300
LYAFLGAKFK TSAQHALTSV SRGSSLKILS KGKRGGHSSV STESESSSFH SS 352
Seq ID NO 239 Protein Sequence
Protein Accession tt NP_036338 1
1 11 21 31 41 51
I I I I I I
MHPQWILSL ILHLADSVAG SVKVGGEAGP SVTLPCHYSG AVTSMCWNRG SCSLFTCQNG 60
IVWTNGTHVT YRKDTRYKLL GDLSRRDVSL TIENTAVSDS GVYCCRVEHR GWFNDMKITV 120
SLEIVPPKVT TTPIVTTVPT VTTVRTSTTV PTTTTVPTTT VPTTMSIPTT TTVPTTMTVS 180
TTTSVPTTTS IPTTTSVPVT TTVSTFVPPM PLPRQNHEPV ATSPSSPQPA ETHPTTLQGA 240
IRREPTSSPL YSYTTDGNDT VTESΞDGLWN NNQTQLFLEH SLLTANTTKG IYAGVCISVL 300
VLLALLGVII AKKYFFKKEV QQLΞVSFSSL QIKALQNAVE KEVQAEDNIY IENSLYATD 359
Seq ID NO 240 Protein Sequence
Protein Accession ft NP_004923 1
1 11 21 31 41 51
I I I I I I
MRTYRYFLLL FWVGQPYPTL STPLSKRTSG FPAKKRALEL SGNSKNELNR SKRSWMWNQF 60
FLLEEYTGSD YQYVGKLHSD QDRGDGSLKY ILSGDGAGDL FIINENTGDI QATKRLDREE 120
KPVYILRAQA INRRTGRPVE PESEFIIKIH DINDNEPIFT KEVYTATVPE MSDVGTFWQ 180
VTATDADDPT YGNSAKWYS ILQGQPYFSV ESETGIIKTA LLNMDRENRE QYQWIQAKD 240
MGGQMGGLSG TTTVNITLTD VNDNPPRFPQ STYQFKTPES SPPGTPIGRI KASDADVGEN 300
AEIEYSITDG EGLDMFDVIT DQETQEGIIT VKKLLDFEKK KVYTLKVEAS NPYVEPRFLY 360
LGPFKDSATV RI EDVDEP PVFSKLAYIL QIREDAQINT TIGSVTAQDP DAARNPVKYS 420
VDRHTDMDRI FNIDSGNGSI FTSKLLDRET LLWHNITVIA TEINNPKQSS RVPLYIKVLD 480
VNDNAPEFAE FYETFVCEKA KADQLIQTLH AVDKDDPYSG HQFSFSLAPE AASGSNFTIQ 540
DNKDNTAGIL TRKNGYNRHE MSTYLLP I SDNDYPVQSS TGTVTVRVCA CDHHGNMQSC 600
HAEALIHPTG LSTGALVAIL LCIVILLVTV VLFAALRRQR KKEPLIISKE DIRDNIVSYN 660
DEGGGEEDTQ AFDIGTLRNP EAIEDNKLRR DIVPEALFLP RRTPTARDNT DVRDFINQRL 720
KENDTDPTAP PYDΞLATYAY EGTGSVADSL SSLESVTTDA DQDYDYLSDW GPRFKKLADM 780
YGGVDSDKDS 790
Seq ID NO 241 Protein Sequence Protein Accession II BAB14227 1 1 11 21 31 41 SI
I I I I I I
MRRLTRRLVL PVFGVLWITV LLFFWVTKRK LEVPTGPEVQ TPKVWSLFFK VAGMSPWAPQ 60
VPVSPTPPYQ RGHLPTGGHL AVCHFPCLLQ EAQFHLQTQV FLQVRCTLLV YCTDLPPTSI 120
IITFHNEARS TLLRTIRSVL NRTPTHLIRE IILVDDFSND PDDCKQLIKL PKVKCLRNNE 180
RQGLVRSRIR GADIAQGTTL TFLDSHCEVN RDWLQPLLHR VKEDYTRWC PVIDIINLDT 240
FTYIESASEL RGGFDWSLHF QWEQLSPEQK ARRLDPTEPI RTPIIAGGLF VIDKAWFDYL 300
GKYDMDMDIW GGENFEISFR VWMCGGSLEI VPCSRVGHVF RKKHPYVFPD GNANTYIKNT 360
KRTAEVWMDE YKQYYYAARP FALERPFGNV ESRLDLRKNL RCQSFKWYLE NIYPELSIPK 420
ESSIQKGNIR QRQKCLESQR QNNQETPNLK LSPCAKVKGE DAKSQVWAFT YTQQILQEEL 480
CLSVITLFPG APWLVLCKN GDDRQQWTKT GSHIEHIASH LCLDTDMFGD GTENGKEIW 540
NPCESSLMSQ HWDMVSS 557
Seq ID NO 242 Protein Sequence Protein Accession tt AAH10659 1 11 21 31 41 51
I I I I I I
MRRLTRRLVL PVFGVLWITV LLFFWVTKRK LEVPTGPEVQ TPKPSDADWD DLWDQFDERR 60
YLNAKKWRVG DDPYKLYAFN QRESERISSN RAIPDTRHLR CTLLVYCTDL PPTSIIITFH 120 NEARSTLLRT IRSVLNRTPT HLIREIILVD DFSNDPDDCK QLIKLPKVKC LRNNERQGLV 180
RSRIRGADIA QGTTLTFLDΞ HCEVNRDWLQ PLLHRVKEDY TRWCPVIDI INLDTFTYIE 240
SASELRGCFD WSLHFQWEQL SPEQKARRLD PTEPIRTPII AGGLFVIDKA WFDYLGKYDM 300
DMDIWGGENF EJSFRVWMCG GSLEIVPCSR VGHVFRKKHP YVFPDGNANT YIKNTKRTAE 360
VWMDEYKQYY YAARPFALER PFGNVESRLD LRKNLRCQSF KWYLENIYPE LSIPKESSIQ 420 KGNIRQRQKC LESQRQNNQE TPNLKLSPCA KVKGEDAKSQ VWAFTYTQQI LQEELCLSVI 480
TLFPGAPWL VLCKNGDDRQ QWTKTGSHIE HIASHLCLDT DMFGDGTENG KEIWNPCES 540
SLMSQHWDMV SS SS2
Seq ID NO 243 Protein Sequence Protein Accession || AAH10659 1
1 11 21 31 41 51
I I I I I I
MRRLTRRLVL PVFGVLWITV LLFFWVTKRK LEVPTGPEVQ TPKPSDADWD DLWDQFDERR 60
YLNAKKWRVG DDPYKLYAFN QRESERISSN RAIPDTRHLS VLNRTPTHLI REIILVDDFS 120 NDPDDCKQLI KLPKVKCLRN NERQGLVRSR IRGADIAQGT TLTFLDSHCE VNRDWLQPLL 180
HRVKEDYTRV VCPVIDIINL DTFTYIESAS ELRGGFDWSL HFQWEQLSPE QKARRLDPTE 240
PIRTPIIAGG LFVIDKAWFD YLGKYDMDMD IWGGENFEIS FRVWMCGGSL EIVPCSRVGH 300
VFRKKHPYVF PDGNANTYIK NTKRTAEVWM DEYKRYYYAA RPFALERPFG NVESRLDLRK 360
NLRCQSFKWY LENIYPELSI PKESSIQKGN IRQRQKCLES QRQNNQETPN LKLSPCAKVK 420 GEDAKSQVWA FTYTQQILQE ELCLSVITLF PGAPWLVLC KNGDDRQQWT KTGSHIEHIA 480
SHLCLDTDMF GDGTENGKEI NPCESSLM SQHWDMVSS 519
Seq ID NO 244 Protein Sequence
Protein Accession tt NP_078848 1
1 11 21 31 41 51
I I I I I I
MNGKVWSGPG FGALTSPRAH SDFLDSHCEV NRDWLQPLLH RVKEDYTRW CPVIDIINLD 60
TFTYIESASE LRGGFDWSLH FQWEQLSPEQ KARRLDPTEP IRTPIIAGGL FVIDKAWFDY 120
LGKYDMDMDI WGGENFEISF RVWMCGCSLE IVPCSRVGHV FRKKHPYVFP DGNANTYIKN 180
TKRTAEVWMD EYKQYYYAAR PFALERPFGN VESRLDLRKN LRCQSFKWYL ENIYPELSIP 240
KESSIQKGNI RQRQKCLESQ RQNNQETPNL KLSPCAKVKG EDAKSQVWAF TYTQQILQEE 300
LCLSVITLFP GAPWLVLCK NGDDRQQWTK TGSHIEHIAS HLCLDTDMFG DGTENGKEIV 360
VNPCESSLMS QHWDMVSS 378
Seq ID NO 245 Protein Sequence
Protein Accession # NP_001209 1
1 11 21 31 41 51
I I I I I I
MPRRSLHAAA VLLLVILKEQ PSSPAPVNGS KWTYFGPDGE NSWSKKYPSC GGLLQSPIDL 60 HSDILQYDAS LTPLEFQGYN LSANKQFLLT NNGHSVKLNL PSDMHIQGLQ SRYSATQLHL 120
HWGNPNDPHG SEHTVSGQHF AAELHIVHYN SDLYPDASTA SNKSEGLAVL AVLIEMGSFN 180
PSYDKIFSHL QHVKYKGQEA FVPGFNIEEL LPERTAEYYR YRGSLTTPPC NPTVLWTVFR 240
NPVQISQEQL LALETALYCT HMDDPSPREM INNFRQVQKF DERLVYTSFS QVQVCTAAGL 300
SLGIILSLAL AGILGICIW WSIWLFRRK SIKKGDNKGV IYKPATKMET EAHA 354
Seq ID NO 246 Protem Sequence
Protein Accession II BC000278
1 11 21 31 41 51
I I I I I I
MPRRSLHAAA VLLLVILKEQ PSSPAPVNGS KWTYFGPDGE NSWSKKYPSC GGLLQSPIDL 60
HSDILQYDAS LTPLEFQGYN LSANKQFLLT NNGHSVKLNL PSDMHIQGLQ SRYSATQLHL 120
HWGNPNDPHG SEHTVSGQHF AAELHIVHYN SDLYPDASTA SNKSEGLAVL AVLIEMGSFN 180
PSYDKIFSHL QHVKYKGQEA FVPGFNIEEL LPERTAEYYR YRGSLTTPPC NPTVLWTVFR 240
NPVQISQEQL LALETALYCT HMDDPSPREM INNFRQVQKF DERLVYTSFS QGIILSLALA 300
GILGICIVW VSIWLFRRKS IKKGDNKGVI YKPATKMETE AHA 343
Seq ID NO 247 Protein Sequence
Protein Accession tt NP_006623 1
1 11 21 31 41 51 I I I I I I
MQVDETLIPR KGPSLCSARY GIALVLHFCN FTTIAQNVIM NITMVAMVNS TSPQSQLNDS 60 SEVLPVDSFG GLSKAPKSLP AKSSILGGQF AIWEKWGPPQ ERSRLCSIAL SGMLLGCFTA 120 ILIGGFISET LGWPFVFYIF GGVGCVCCLL WFWIYDDPF SYPWISTSEK EYIISSLKQQ 180 VGSΞKQPLPI KAMLRSLPIW SICLGCFSHQ WLVSTM YI PTYISSVYHV NIRDNGLLSA 240 LPFIVAWVIG MVGGYLADFL LTKKFRLITV RKIATILGSL PSSALIVSLP YLNSGYITAT 300 ALLTLSCGLS TLCQSGIYIN VLDIAPRYSS FLMGASRGFS SIAPVIVPTV SGFLLSQDPE 360 FGWRNVFFLL FAVNLLGLLF YLIFGEADVQ EWAKERKLTR L 401
Seq ID NO 248 Protein Sequence
Protein Accession # NP_003049 1
1 11 21 31 41 51
I I I I I I
MPTTVDDVLE HGGEFHFFQK QMFFLLALLS ATFAPIYVGI VFLGFTPDHR CRSPGVAELS 60
LRCGWSPAEE LNYTVPGPGP AGEASPRQCR RYEVDWNQST FDCVDPLASL DTNRSRLPLG 120
PCRDGWVYET PGSSIVTEFN LVCANSWMLD LFQSSVNVGF FIGSMSIGYI ADRFGRKLCL 180
LTTVLINAAA GVLMAISPTY TWMLIFRLIQ GLVSKAGWLI GYILITEFVG RRYRRTVGIF 240
YQVAYTVGLL VLAGVAYALP HWRWLQFTVA LPNFFFLLYY WCIPESPRWL ISQNKNAEAM 300
RIIKHIAKKN GKSLPASLQR LRLEEETGKK LNPSFLDLVR TPQIRKHTMI LMYNWFTSΞV 360
LYQGLIMHMG LAGDNIYLDF FYSALVEFPA AFMIILTIDR IGRRYPWAAS NMVAGAACLA 420 SVFIPGDLQW LKIIISCLGR MGITMAYEIV CLVNAELYPT FIRNLGVHIC SSMCDIGGII 480
TPFLVYRLTN IWLELPLMVF GVLGLVAGGL VLLLPETKGK ALPETIEEAE NMQRPRKNKE 540
KMIYLQVQKL DIPLN S5S Seq ID NO: 249 Protein Sequence
Protein Accession It. Eos sequence
1 11 21 31 41 51
I I I I I I
MQPAIQVWFG EDLPLSPRSP LTPRHGPGLA NVCQYDEWIA VRHEATLLPM QEDLSIWLSG 60 LLGIKVKAEK LLEELDNGVL LCQLIDVLQN MVKTCNSEES GNFPMRKVPC KKDAASGSFF 120
ARDNTANFLH WCRDIGVDET YLFESEGLVL HKDPRQVYLC LLEIGRIVSR YGVEPPVLVK 180
LEKEIELEET LLNTSGPEDΞ ISIPKSCCRH EELHEAVKHI AEDPPCSCSH RFSIEYLSEG 240
RYRLGDKILF IRMLHGKHVM VRVGGGWDTL QGFLLKYDPC RILQFATLEQ KILAFQKGVS 300
NESVPDSPAR TPQPPEMNPL SAVNMFQKQN SKPSVPVSIP KSKEKQGRPP GALVPASSLK 360
GGNLGSMSVR SKLPNSPAAS SHPKLKSSKG ITKKPQAPSN NASSSLASLN PVGKNTSSPA 420
LPRTAPCISE SPRKCISSPN TPKAKVIPAQ NSADLPESTL LPNKCSGKTQ PKYLKHNHIS 480
SRDNAVSHLA AHSNSSSKCP KLPKANIPVR PKPSFQSSAK MTKTSSKTIA TGLGTQSQPS 540
DGAPQAKPVP AQKLKSALNL NQPVSVSSVS PVKATQKSKD KNIVSATKKQ PQNKSAFQKT 600
GPSSLKSPGR TPLSIVSLPQ SSTKTQTAPK SAQTVAKSQH STKGPPRSGK TPASIRKPPS 660
SVKDADSGDK KPTAKKKEDD DHYFVMTGSK KPRK 694
Seq ID NO: 250 Protein Sequence
Protein Accession tt -. NP_001035.1
1 11 21 31 41 51 i i i i i i
MSKSKCSVGL MSSWAPAKE PNAVGPKEVE LILVKEQNGV QLTSSTLTNP RQSPVEAQDR 60
ETWGKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV PYLLFMVIAG MPLFYMELAL 120
GQFNREGAAG VWKICPILKG VGFTVILISL YVGFFYNVII AWALHYLFSS FTTELPWIHC 180
NNSWNSPNCS DAHPGDSSGD SSGLNDTFGT TPAAEYFERG VLHLHQSHGI DDLGPPRWQL 240
TACLVLVIVL LYFSLWKGVK TSGKWWITA TMPYWLTAL LLRGVTLPGA IDGIRAYLSV 300
DFYRLCEASV WIDAATQVCF SLGVGFGVLI AFΞSYNKFTN NCYRDAIVTT SINSLTSFSS 360
GFWFSFLGY MAQKHSVPIG DVAKDGPGLI FIIYPEAIAT LPLSSAWAW FFIMLLTLGI 420
DSAMGGMESV ITGLIDEFQL LHRHRELFTL FIVLATFLLS LFCVTNGGIY VFTLLDHFAA 480
GTSILFGVLI EAIGVAWFYG VGQFSDDIQQ MTGQRPSLYW RLCWKLVSPC FLLFWWSI 540
VTFRPPHYGA YIFPDWANAL GWVIATSSMA MVPIYAAYKF CSLPGSFREK LAYAIAPEKD 600
RELVDRGEVR QFTLRHWLKV 620
Seq ID NO: 251 Protein Sequence
Protein Accession It: NP_071356.1
1 11 21 31 41 51
I I I I I I
MPLGHIMRLD LEKIALEYIV PCLHEVGFCY LDNFLGE G DCVLERVKQL HCTGALRDGQ 60
LAGPRAGVSK RHLRGDQITW IGGNEEGCEA ISFLLSLIDR LVLYCGSRLG KYYVKERSKA 120
MVACYPGNGT GYVRHVDNPN GDGRCITCIY YLNKNVIDAKL HGGILRIFPE GKSFIADVEP 180
IFDRLLFFWS DRRNPHEVQP SYATRYAMTV WYFDAEERAE AKKKFRNLTR KTESALTED 239
Seq ID NO: 252 Protein Sequence Protein Accession # : NP_647475.1
1 11 21 31 41 51 I I I I I I
MSGAPTAGAA LMLCAATAVL LSAQGGPVQS KSPRFASWDE MNVLAHGLLQ LGQGLREHAE 60
RTRSQLSALE RRLSACGSAC QGTEGSTDLP LAPESRVDPE VLHSLQTQLK AQNSRIQQLF 120
HKVAQQQRHL EKQHLRIQHL QSQFGLLDHK HLDHEVAKPA RRKRLPEMAQ PVDPAHNVSR 180
LHRLPRDCQE LFQVGERQSG LFEIQPQGSP PFLVNCKMTS DCCWTVIQRR HDGSVDFNRP 240
WEAYKAGFGD PHGEFWLGLE KVHSITGDRN SRLAVQLRDW DGNAELLQFS VHLGGEDTAY 300
SLQLTAPVAG QLGATTVPPS GLSVPFSTWD QDHDLRRDKN CAKSLSGGWW FGTCSHSNLN 360
GQYFRSIPQQ RQKLKKGIFW KTWRGRYYPL QATTMLIQPM AAEAAS 406
Seq ID NO: 2S3 Protein Sequence
Protein Accession If: NP_001207.1
1 11 21 31 41 51
I I I I I I
MAPLCPSPWL PLLIPAPAPG LTVQLLLSLL LLMPVHPQRL PRMQEDSPLG GGSSGEDDPL 60
GEEDLPSEED SPREEDPPGE EDLPGEEDLP GEEDLPEVKP KSEEEGSLKL EDLPTVEAPG 120
DPQEPQNNAH RDKEGDDQSH WRYGGDPPWP RVSPACAGRF QSPVDIRPQL AAFCPALRPL 180
ELLGFQLPPL PELRLRNNGH SVQLTLPPGL EMALGPGREY RALQLHLHWG AAGRPGSEHT 240
VEGHRFPAEI HWHLSTAFA RVDEALGRPG GLAVLAAFLE EGPEENSAYE QLLSRLEEIA 300
EEGSETQVPG LDISALLPSD FSRYFQYEGS LTTPPCAQGV IWTVFNQTVM LSAKQLHTLS 360
DTLWGPGDSR LQLNFRATQP LNGRVIEASF PAGVDSSPRA AEPVQLNSCL AAGDILALVF 420
GLLFAVTSVA FLVQMRRQHR RGTKGGVSYR PAEVAETGA 459
Seq ID NO: 254 Protein Sequence
Protein Accession It : NP_003030 1
1 11 21 31 41 51
I I I I I I
MEQQDQSMKE GRLTLVLALA TLIAAFGSSF QYGYNVAAVN SPALLMQQFY NETYYGRTGE 60
FMEDFPLTLL WSVTVSMFPF GGFIGSLLVG PLVNKFGRKG ALLFNNIFSI VPAILMGCSR 120
VATSFELIII SRLLVGICAG VSSNWPMYL GELAPKNLRG ALG PQLFI TVGILVAQIF 180
GLRNLLANVD GWPILLGLTG VPAALQLLLL PFFPESPRYL LIQKKDEAAA KKALQTLRGW 240
DSVDREVAEI RQEDEAEKAA GFISVLKLFR MRSLRWQLLS IIVLMGGQQL SGVNAIYYYA 300
DQIYLSAGVP EEHVQYVTAG TGAVNWMTF CAVFWELLG RRLLLLLGFS ICLIACCVLT 360
AALALQDTVS WMPYISIVCV ISYVIGHALG PSPIPALLIT EIFLQSSRPS AFMVGGSVHW 420
LSNFTVGLIF PFIQEGLGPY SFIVFAVICL LTTIYIFLIV PETKAKTFIE INQIFTKMNK 480
VSEVYPEKEE LKELPPVTSE Q 501 Seq ID NO- 255 Protein Sequence
Protein Accession ■ NP_001243.1
1 11 21 31 41 51
I I I I I I
MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLWCIQR FAQAQQQLPL ESLGWDVAEL 60
QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR DGIYMVHIQV TLAICSSTTA 120
SRHHPTTLAV GICSPASRSI SLLRLSFHQG CTIASQRLTP LARGDTLCTN LTGTLLPSRN 180
TDETFFGVQW VRP 193 0
Seq ID NO: 256 Protein Sequence
Protein Accession If- NP_060562.2
1 11 21 31 41 51 C I I I I I I J MLFTSFVEQK KKAGVFEQIT KTHGTIIGIT SGIVLVLLII SILVQVKQPR KKVMACKTAF 60
NKTGFQEVFD PPHYELFSLR DKEISADLAD LSEELDNYQR MRRSSTASRC IHDHHCGSQA 120
SSVKQSRTNL SSMELPLRND FAQPQPMKTF NSTFKKSSYT FKQGHECPEQ ALEDRVMEEI 180 PCEIYVRGRE DSAQASISID F 201 0 Seq ID NO: 2S7 Protein Sequence
Protein Accession tl : Eos sequence
1 11 21 31 41 51
I I I I I I
IIAATINNAS MTSPIDNAGL AADDFKMNAS LQTQISTDAE AVSSAKSEIM ELKQVLQSLQ 60 5 HELQSVLAMQ SSPEGTLADT EAGYVAQLSE IKMYISILEE QICQIRGETE YQNTEYAQLQ 120
DIKTRLEVEI ETYHRLLGGE GGSEAREAES KG 152
Seq ID NO: 258 Protein Sequence
Protein Accession tl : NP_003256.1 0 1 11 21 31 41 51
I I I I I I
MRQTLPCIYF WGGLLPFGML CASSTTKCTV SHEVADCSHL KLTQVPDDLP TNITVLNLTH 60
NQLRRLPAAN FTRYSQLTΞL DVGFNTISKL EPELCQKLPM LKVLNLQHNE LSQLSDKTPA 120
FCTNLTELHL MSNSIQKIKN NPFVKQKNLI TLDLSHNGLS STKLGTQVQL ENLQELLLSN 180 5 NKIQALKSEE LDIFANSSLK KLELSSNQIK EFSPGCFHAI GRLFGLFLNN VQLGPSLTEK 240
LCLELANTSI RNLSLSNSQL ΞTTSNTTFLG LKWTNLTMLD LSYNNLNWG NDSFAWLPQL 300
EYFFLEYNNI QHLFSHSLHG LFNVRYLNLK RSFTKQSISL ASLPKIDDFS FQWLKCLEHL 360
NMEDNDIPGI KSNMFTGLIN LKYLSLSNSF TSLRTLTNET FVSLAHSPLH ILNLTKNKIS 420
KIESDAFSWL GHLEVLDLGL NEIGQELTGQ EWRGLENIFE IYLSYNKYLQ LTRNSFALVP 480 0 SLQRLMLRRV ALKNVDSSPS PFQPLRNLTI LDLSNNNIAN INDDMLEGLE KLEILDLQHN 540
NLARLWKHAN PGGPIYFLKG LSHLHILNLE SNGFDEIPVE VFKDLFELKI IDLGLNNLNT 600
LPASVFNNQV SLKSLNLQKN LITSVEKKVF GPAFRNLTEL DMRFNPFDCT CESIAWFVNW 660
INETHTNIPE LSSHYLCNTP PHYHGFPVRL FDTSSCKDSA PFELFFMINT SILLIFIFIV 720
LLIHFEGWRI SFYWNVSVHR VLGFKEIDRQ TEQFEYAAYI IHAYKDKDWV WEHFSSMEKE 780 5 DQSLKFCLEE RDFEAGVFEL EAIVNSIKRS RKIIFVITHH LLKDPLCKRF KVHHAVQQAI 840
EQNLDSIILV FLEEIPDYKL NHALCLRRGM FKSHCILNWP VQKERIGAFR HKLQVALGSK 900
NSVH 904
Seq ID NO: 259 Protein Sequence 0 Protein Accession It . NP_000570.l
1 11 21 31 41 51
I I I I I I
MDYQVSSPIY DINYYTSEPC QKINVKQIAA RLLPPLYSLV FIFGFVGNML VILILINCKR 60
LKSMTDIYLL NLAISDLFFL LTVPFWAHYA AAQWDFGNTM CQLLTGLYFI GFFSGIFFII 120 5 LLTIDRYLAV VHAVFALKAR TVTFGWTSV ITWWAVFAS LPGIIFTRSQ KEGLHYTCSS 180
HFPYSQYQFW KNFQTLKIVI LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFTI 240
MIVYFLFWAP YNIVLLLNTF QEFFGLNNCS SSNRLDQAMQ VTETLGMTHC CINPIIYAFV 300
GEKFRNYLLV FFQKHIAKRF CKCCSIFQQE APERASSVYT RSTGEQEISV GL 352 0 Seq ID NO: 260 Protein Sequence
Protein Accession tt : Eos sequence
1 11 21 31 41 51
I I I I I I
PQGPPGPPGI PGAKGELGLP GAPGIDGEKG PKGQKGDPGE PGPAGLKGEA GEMGLSGLPG 60 5 ADGLKGEKGE SASDSLQESL AQLIVEPGPP GPPGPPGPMG LQGIQGPKGL DGAKGEKGAS 120
GERGPSGLPG PVGPPGLIGL PGTKGEKGRP GEPGLDGFPG PRGEKGDRSE RGEKGERGVP 180
GRKGVKGQKG EPGPPGLDQP CPVGPDGLPV PGCWHK 216
Seq ID NO: 261 Protein Sequence 0 Protein Accession tt : NP_004852.1
1 11 21 31 41 51
I I I I I I
MLPPQKKPWE SMAKGLVLGA LFTSFLLLVY SYAVPPLHAG LASTTPEAAA SCSPPALEPE 60
AVIRANGSAG ECQPRRNIVF LKTHKTASST LLNILFRFGQ KHRLKFAFPN GRNDFDYPTF 120 5 FARSLVQDYR PGACFNIICN HMRFHYDEVR GLVPTNAIFI TVLRDPARLF ESSFHYFGPV 180
VPLTWKLSAG DKLTEFLQDP DRYYDPNGFN AHYLRNLLFF DLGYDNSLDP SSPQVQEHIL 240
EVERRFHLVL LQEYFDESLV LLKDLLCWEL EDVLYFKLNA RRDSPVPRLS GELYGRATAW 300
NMLDSHLYRH FNASFWRKVE AFGRERMARE VAALRHANER MRTICIDCCH AVDAAAIQDE 360
AMQPWQPLGT KSILGYNLKK SIGQRHAQLC RRMLTPEIQY LMDICANLWV TKLWKFIRDF 420 0 LRW 423
Seq ID NO- 262 Protein Sequence
Protein Accession If: NP_061130 1
1 11 21 31 41 51 I I I I I I
MASVLSRRLG KRSLLGARVL GPSASEGPSA APPSEPLLEG AAPQPFTTSD DTPCQEQPKE 60
VLKAPSTSGL QQVAFQPGQK VYVWYGGQEC TGLVEQHSWM EGQVTVWLLE QKLQVCCRVE 120
EVWLAELQGP CPQAPPLEPG AQALAYRPVS RNIDVPKRKS DAVEMDEMMA AMVLTSLSCS 180 PWQSPPGTE ANFSASRAAC DPWKESGDIS DSGSSTTSGH WSGSSGVSTP SPPHPQASPK 240
YLGDAFGSPQ TDHGFETDPD PFLLDEPAPR KRKNSVKVMY KCLWPNCGKV LRSIVGIKRH 300
VKALHLGDTV DSDQFKREED FYYTEVQLKE ESAAAAAAAA AGTPVPGTPT SEPAPTPSMT 360
GLPLSALPPP LHKAQSSGPE HPGPESSLPΞ GALSKSAPGS FWHIQADHAY QALPSFQI PV 420
SPHIYTSVSW AAAPSAACSL SPVRSRSLSF SEPQQPAPAM KSHLIVTSPP RAQSGARKAR 480 GEAKKCRKVY GIEHRDQWCT ACRWKKACQR FLD 513
Seq ID NO : 263 Protein Sequence Prote in Accession It : AB058765 . 2 1 11 21 31 41 51 i i i i i i
MRENYETLVS VGTAELLPLS AFLSPSEPGR AVGGGSHADE GQEPAGCGDP QGGQPRHSLH 60
LTALVQLVKE IPEFLFGEVK GAMDSPESES RGASLDGERA SPEAAAAREP CPLRGLLSCL 120
PDGPTSQPHL ATTPTDSSCS SGPTGDGVQG SPLPIKTADK PWPTRKEGPG ALGGEPSPPT 180
HSPSRRKSHR GQERGTSEAG ISPGNSPLQG LINCLKEILV PGPRHPETSP SFLPPLPSLG 240 TSRLTRADLG PGSPPWAVKT EAVSGDCPLQ GLLHCLKELP EAQDRHPSPS GVGNRRLQEN 300
PGAWKRGSGG PGYLLTPPPH PDLGAGGLLS VKMENSWVQS PPGPASCQPG RQPLSPSATG 360
DTRGVPQPSW GPEAQAASAS SSPLEALEAC LKGIPPNGSS PSQLPPTSCS QNPQPGDSRS 420
QKPELQPHRS HSEEATREPV LPLGLQSCVR DGPSRPLAPR GTPTSFSSSS STDWDLDFGS 480
PVGNQGQHPG KGSPPGSSPL QGLENCLKEI PVPVLRPAWP CSSAADRGPR RAEPRNWTAD 540 KEGLRAEACE SARLGQGRGE APTRSLHLVS PQVFTSSCVP ACHQRGFKDP GATRPGVWRW 600
LPEGSAPKPS PLHCLESALR GILPVRPLRF ACVGGPSPSP SPGSSSSFSG SEGEDPRPEP 660
ELWKPLPQER DRLPSCKPPV PLSPCPGGTP AGSSCCSPGE DPRRTEPRYC SGLGAGTAQD 720
PCPVSQLEKR PRVSEASRGL ELGHGRPRVA AKTHERLLPQ GPPELPSESP PPELPPPEAA 780
PPVLPASSLQ PPCHCGKPLQ QELHSLGAAL AEKLDRLATA LAGLAQEVAT MRTQVNRLGR 840 RPQGPGPMGQ ASWMWTLPRG PRWAHGPGHR HLPYWRQKGP TRPKPKI LRG QGESCRAGDL 900
QGLSRGTARR ARPLPPDAPP AEPPGLHCSS SQQLLSSTPS CHAAPPAHPL LAHTGGHQSP 960
LPPLVPAALP LQGASPPAAS ADADVPTSGV APDGI PERPK EPSSLLGGVQ RALQEELWGG 1020
EHRDPRWGAH 1030 Seq ID NO : 264 Protein Sequence
Protein Accession It : AL831935 1 1 11 21 31 41 51
I I I I I I
PAGCGDPQGG QPRHSLHLTA LVQLVKEIPE FLFGEVKGAM DSPESESRGA SLDGERASPE 60 AAAREPCPLR GLLSCLPDGP TSQPHLATTP TDSSCSSGPT GDGVQGSPLP IKTADKPWPT 120
RKEGPGALGG EPSPPTHSPS RRKSHRGQER GTSEAGISPG NSPLQGLINC LKEILVPGPR 180
HPETSPSFLP PLPSLGTSRL TRADLGPGSP PWAVKTEAVS GDCPLQGLLH CLKELPEAQD 240
RHPSPSGVGN RRLQENPGAW KRGSGGPGYL LTPPPHPDLG AGGLLSVKME NSWVQSPPGP 300
ASCQPGRQPL SPSATGDTRG VPQPSWGPEA QAASASSSPL EALEACLKGI PPNGSSPSQL 360 PPTSCSQNPQ PGDSRSQKPE LQPHRSHSEE ATREPVLPLG LQSCVRDGPS RPLAPRGTPT 420
SFSSSSSTDW DLDFGSPVGN QGQHPGKGSP PGSSPLQGLE NCLKEIPVPV LRPAWPCSSA 480
ADRGPRRAEP RNWTADKEGS APKPSPLHCL ESALRGILPV RPLRFACVGG PSPSPSPGSS 540
SSFSGSEGED PRPEPDLWKP LPQERDRLPS CKPPVPLSPC PCCTPAGSSG GSPGEDPRRT 600
EPRYCSGLGA GEPGVS 616
Seq ID NO: 265 Protein Sequence Protein Accession If: AAH29071 1 1 11 21 31 41 51
I I I I I I
RTRGRTRGRL RSGVMMPLAE AGALAQGGGP SATEWACILR RKTPRHKQPT LLMVRASRRS 60
GKTSAVLKAG RQSVSGRKNS TSKDLVTLGA SSLREERGHP LHPRHRKAVH LRTRGRTRGW 120
VQTLARMSRR TRGPVERAAA AAAAAAGGDA GHAPFPPPPA ADGARAPRSP GQVTPRGLRL 180
RLPRRESLLR GLCRPLRPLL GFRESDSAKP ASLRLLQHTP SARRNYRIAG ARLMRSNYPP 240
PLSSAALRGA GPTRRN 256
Seq ID NO: 266 Protein Sequence
Protein Accession If: NP_002095 1
1 11 21 31 41 51
I I I I I I
MTKFSSFSLF FLIVGAYMTH VCFNMEIICC KEVSPHSRPF MASIQYGGHH VCGGVLIDPQ 60
WVLTAAHCQY RFTKGQSPTV VLGAHSLSKN EASKQTLEIK KFIPFSRVTS DPQSNDIMLV 120
KLQTAAKLNK HVKMLHIRSK TSLRSGTKCK VTGWGATDPD SLRPSDTLRE VTVTVLSRKL 180
CNSQSYYNGD PFITKDMVCA GDAKGQKDSC KGDSGGPLIC KGVFHAIVSG GHECGVATKP 240
GIYTLLTKKY QTWIKSNLVP PHTN 264
Seq ID NO: 257 Protein Sequence
Protein Accession #: NP_443179.1
1 11 21 31 41 51
I I I I I I
MQVNTLFETS QVPDWSDPPQ VQVQETVRET ISCSQMPAFS EPAGEESPFT GTTTISFSNL 60
GGVHKENASL AQHSEVKPCT CGPQQEEKQD RDGNIPDNFR EDLKYEQSIS EANDETMSPG 120
VFSRHLPKDA RADFREPVAV SVASPEPTDT ALTLENVCDE PRDREAVCAM ECFEASDQGT 180
CFDTIDSLVG TPVDNYSPQE ICSVDTELAE GQNKVSDLCS SNDKTLEVFF QTQVSETSVS 240
TCKSSKDGNS VMSPLFISTF TLNISHTASE GATGENLAKV EKSTYPLAST VHAGQEQPSP 300
SNSGGLDETQ LLSSENNPLV QFKEGGDKSP SPSAADTTAT PASYSSIVSF PWEKPTTLTA 360
NNECFQATRE TVTIATEVHP AKYLAVSIPE DKHAGGTEER FPRASHEKVS QFPSQVQVDH 420
ILSGATIKST KELLCRAPSV PGVPHHVLQL PEGEGFCSNS PLQVDNLSGD KSQTVDRADF 480
RSYEENFQER GSETKQGVQQ QSLSQQGSLS APDFQQSLPT TSAAQEERNL VPTAPSPASS 540
REGAGQRSGW GTRVSWAET AGEEDSQALS NVPSLSDILL EESKEYRPGN WEAGNKLKII 600 TLEASASEIW PPRQLTNSES KASDGGLIIP DKVWAVPDSL KADAWPELA PSEIAALAHS 660
PEDAESALAD SRESHKGEEP TISVHWRSLS SRGFSQPRLL ESSVDPVDEK ELSVTDSLSA 720
ASETGGKENV NNVSQDQEEK QLKMDHTAFF KKFLTCPKIL ESSVDPIDEI SVIEYTRAGK 780
PEPSETTPQG AREGGQSNDG NMGHEAEIQS AILQVPCLQG TILSENRISR SQEGSMKQEA 840
5 EQIQPEEAKT AIWQVLQPSE GGERIPSGCS IGQIQESSDG SLGEAEQSKK DKAELISPTS 900
PLSSCLPIMT HSSLGVDTHN STGQIHDVPE NDIVEPRKRQ YVFPVSQKRG TIENERGKPL 960
PSSPDLTRFP CTSSPEGNVT DFLISHKMEE PKIEVLQIGE TKPPSSSSSS AKTLAFISGE 1020
RELEKAPKLL QDPCQKGTLG CAKKSREREK SLEARAGKSP GTLTAVTGSE EVKRKPEAPG 1080
SGHLAEGVKK KILSRVAALR LKLEEKENIR KNSAFLKKMP KLETSLSHTE EKQDPKKPSC 1140
10 KREGRAPVLL KKIQAEMFPE HSGNVKLSCQ FAEIHEDSTI CWTKDSKSIA QVQRSAGDNS 1200
TVSFAIVQAS PKDQGLYYCC IKNSYGKVTA EFNLTAEVLK QLSSRQDTKG CEEIEFSQLI 1260
FKEDFLHDSY FGGRLRGQIA TEELHFGEGV HRKAFRSTVM HGLMPVFKPG HACVLKVHNA 1320
IAYGTRNNDE LIQRNYKLAA QECYVQNTAR YYAKIYAAEA QPLEGFGEVP EIIPIFLIHR 1380
PENNIPYATV EEELIGEFVK YSIRDGKEIN FLRRESEAGQ KCCTFQHWVY QKTSGCLLVT 1440
15 DMQGVGMKLT DVGIATLAKG YKGFKGNCSM TFIDQFKALH QCNKYCKMLG LKSLQNNNQK 1500
QKQPSIGKSK VQTNSMTVKK AGPETPGEKK T 1531
Seq ID NO 268 Protein Sequence
Protein Accession # NP_602293 1
20 1 11 21 31 41 51
I I I I I I
MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD 60
ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE 120
MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV 180
25 RLLQCDPSSA SQF 193
Seq ID NO 269 Protein Sequence Protein Accession tt NP_002140 2 „„ 1 11 21 31 41 51
30 I I I I I I
MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD 60 ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE 120 MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV 180 RLLQCDPSSA SQF 193
Seq ID NO 270 Protein Sequence
Protein Accession # NP_003937 1
1 11 21 31 41 51
4 ΛΓUK M IGNAQERPSE T IIDRERKRLV E ITLQADSGLL L IDALLARGVL TIGPEYEALDA LIPDAERRVRR 60
LLLLVQGKGE AACQELLRCA QRTAGAPDPA WDWQHVGPGY RDRSYDPPCP GHWTPEAPGS 120
GTTCPGLPRA SDPDEAGGPE GSEAVQSGTP EEPEPELEAE ASKEAEPEPE PEPELEPEAE 180
AEPEPELEPE PDPEPEPDFE ERDESEDS 208
45 Seq ID NO 271 Protein Sequence
Protein Accession it NP_004198 1
1 11 21 31 41 51
I I I I I I
MGGAWDEGP TGVKAPDGGW GWAVLFGCFV ITGFSYAFPK AVSVFFKELI QEFGIGYSDT 60
50 AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL GMVAASFCRS IIQVYLTTGV 120
ITGLGLALNF QPSLIMLNRY FSKRRPMANG LAAAGSPVFL CALSPLGQLL QDRYGWRGGF 180
LILGGLLLNC CVCAALMRPL WTAQPGSGP PRPSRRLLDL SVFRDRGFVL YAVAASVMVL 240
GLFVPPVFW SYAKDLGVPD TKAAFLLTIL GFIDIFARPA AGFVAGLGKV RPYSVYLFSF 300
SMFFNGLADL AGSTAGDYGG LWFCIFFGI SYGMVGALQF EVLMAIVGTH KFSSAIGLVL 360
55 LMEAVAVLVG PPSGGKLLDA THVYMYVFIL AGAEVLTSSL ILLLGNFFCI RKKPKEPQPE 420
VAAAEEEKLH KPPADSGVDL REVEHFLKAE PEKNGE HT PETSV 465
Seq ID NO 272 Protein Sequence
Protein Accession tt NP_060705 1
60 1 11 21 31 41 51
I I I I I I
MAALTTLFKY IDENQDRYIK KLAKWVAIQS VSAWPEKRGE IRRMMEVAAA DVKQLGGSVE 60
LVDIGKQKLP DGSEIPLPPI LLGRLGSDPQ KKTVCIYGHL DVQPAALEDG WDSEPFTLVE 120
RDGKLYGRGS TDDKGPVAGW INALEAYQKT GQEIPVNVRF CLEGMEESGS EGLDELIFAR 180
65 KDTFFKDVDY VCISDNYWLG KKKPCITYGL RGICYFFIEV ECSNKDLHSG VYGGSVHEAM 240
TDLILLMGSL VDKRGNILIP GINEAVAAVT EEEHKLYDDI DFDIEEFAKD VGAQILLHSH 300
KKDILMHRWR YPSLSLHGIE GAFSGSGAKT VIPRKWGKF SIRLVPNMTP EWGEQVTSY 360
LTKKFAELRS PNEFKVYMGH GGKPWVSDFS HPHYLAGRRA MKTVFGVEPD LTREGGSIPV 420
TLTFQEATGK NVMLLPVGSA DDGAHSQNEK LNRYNYIEGT KMLAAYLYEV SQLKD 475
70
Seq ID NO 273 Protein Sequence Protein Accession # AF258592_1 1 11 21 31 41 51
75 I I I I I I
MAALTTLFKY IDENQDRYIK KLAKWVAIQS VSAWPEKRGE IRRMMEVAAA DVKQLGGSVE 60
LVDIGKQKEI PVNVRFCLEG MEESGSEGLD ELIFARKDTF FKDVDYVCIS DNYWLGKKKP 120
CITYGLRGIC YFFIEVECSN KDLHSGVYGG SVHEAMTDLI LLMGSLVDKR GNILIPGINE 180
AVAAVTEEEH KLYDDIDFDI EEFAKDVGAQ ILLHSHKKDI LMHRWRYPSL SLHGIEGAFS 240
GSGAKTVIPR KWGKFSIRL VPNMTPEWG EQVTSYLTKK FAELRSPNEF KVYMGHGGKP 300
80 WVSDFSHPHY LAGRRAMKTV FGVEPDLTRE GGSIPVTLTF QEATGKNVML LPVGSADDGA 360
HSQNEKLNRY NYIEGTKMLA AYLYEVSQLK D 391
Seq ID NO 274 Protein Sequence Protein Accession # NP 060871 1 1 11 21 31 41 51
I I I I I I
MGGNHSHKPP VFDENEEVNF DHFQILRAIG KGΞFGKVCIV QKRDTKKMYA MKYMNKQKCI 60
ERDEVRNVFR ELQIMQGLEH PFLVNLWYSF QDEEDMFMW DLLLGGDLRY HLQQNVHFTE 120
GTVKLYICEL ALALEYLQRY HIIHRDIKPD NILLDEHGHV HITDFNIATV VKGAERASSM 180
AGTKPYMAPE VFQVYMDRGP GYSYPVDWWS LGITAYELLR GWRPYEIHSV TPIDEILNMF 240
KVERVHYSST WCKGMVALLR KLLTKDPESR VSΞLHDIQSV PYLADMNWDA VFKKALMPGF 300
VPNKGRLNCD PTFELEEMIL ESKPLHKKKK RLAKNRSRDG TKDSCPLNGH LQHCLETVRE 360
EFIIFNREKL RRQQGQGSQL LDTDSRGGGQ AQSKLQDGCN NNLLTHTCTR GCSS 414
Seq ID NO 275 Protein Sequence
Protein Accession II NP_004198 1
1 11 21 31 41 51
I I I I I I
MGGAWDEGP TGVKAPDGGW GWAVLFGCFV ITGFSYAFPK AVSVFFKELI QEFGIGYSDT 60
AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL GMVAASFCRS IIQVYLTTGV 120
ITGLGLALNF QPSLIMLNRY FSKRRPMANG LAAAGSPVFL CALSPLGQLL QDRYGWRGGF 180
LI GGLLLNC CVCAALMRPL WTAQPGSGP PRPSRRLLDL SVFRDRGFVL YAVAASVMVL 240
GLFVPPVFW SYAKDLGVPD TKAAFLLTIL GFIDIFARPA AGFVAGLGKV RPYSVYLFSF 300
SMFFNGLADL AGSTAGDYGG LWFCIFFGI SYGMVGALQF EVLMAIVGTH KFSSAIGLVL 360
LMEAVAVLVG PPSGGKLLDA THVYMYVFIL AGAEVLTSSL ILLLGNFFCI RKKPKEPQPE 420
VAAAEEEKLH KPPADSGVDL REVEHFLKAE PEKNGEWHT PETSV 465
Seq ID NO 276 Protein Sequence
Protein Accession II NP_006589 1
1 11 21 31 41 51
I I I I I I
MPTNFTWPV EAHADGGGDE TAERTEAPGT PEGPEPERPS PGDGNPRENS PFLNNVEVEQ 60
ESFFEGKNMA LFEEEMDSNP MVSSLLNKLA NYTNLSQGW EHEEDEESRR REAKAPRMGT 120
FIGVYLPCLQ NILGVILFLR LTWIVGVAGV LESFLIVAMC CTCTMLTAIS MSAIATNG 180
PAGGSYYMIS RSLGPEFGGA VGLCFYLGTT FAGAMYILGT IEIFLTYISP GAAIFQAEAA 240
GGEAAAMLHN MRVYGTCTLV LMALWFVGV KYVNKLALVF LACWLΞILA IYAGVIKSAF 300
DPPDIPVCLL GNRTLSRRSF DACVKAYGIH NNSATSALWG LFCNGSQPSA ACDEYFIQNN 360
VTEIQGIPGA ASGVFLENLW STYAHAGAFV EKKGVPSVPV AEESRASTLP YVLTDIAASF 420
TLLVGIYFPS VTGIMAGSNR SGDLKDAQKS IPTGTILAIV TTSFIYLSCI VLFGACIEGV 480
VLRDKFGEAL QGNLVIGMLA WPSPWVIVIG SFFSTCGAGL QTLTGAPRLL QAIARDGIVP 540
FLQVFGHGKA NGEPTWALLL TVLICETGIL IASLDSVAPI LSMFFLMCYL FVNLACAVQT 600
LLRTPNWRPR FKFYHWTLSF LGMSLCLALM FICSWYYALS AMLIAGCIYK YIEYRGAEKE 660
WGDGIRGLSL NAARYALLRV EHGPPHTKNW RPQVLVMLNL DAEQAVKHPR LLSFTSQLKA 720
GKGLTIVGSV LEGTYLDKHM EAQRAEENIR SLMSTEKTKG FCQLWSSSL RDGMSHLIQS 780
AGLGGLKHNT VLMAWPASWK QEDNPFSWKN FVDTVRDTTA AHQALLVAKN VDSFPQNQER 840
FGGGHIDVWW IVHDGGMLML LPFLLRQHKV WRKCRMRIFT VAQVDDNSIQ MKKDLQMFLY 900
HLRISAEVEV VEMVENDISA FTYERTLMME QRSQMLKQMQ LSKNEQEREA QLIHDRNTAS 960
HTAAAARTQA PPTPDKVQMT WTREKLIAEK YRSRDTΞLSG FKDLFSMKPD QSNVRRMHTA 1020
VKLNGWLNK ΞQDAQLVLLN MPGPPKNRQG DENYMEFLEV LTEGLNRVLL VRGGGREVIT 1080
IYS 1083
Seq ID NO 277 Protein Sequence
Protein Accession tt NP_004576 1
1 11 21 31 41 51
I I I I I I
MASPHQEPKP GDLIEIFRLG YEHWALYIGD GYVIHLAPPS EYPGAGSSSV FSVLSNSAEV 60
KRGRLEDWG GCCYRVNNSL DHEYQPRPVE VIISSAKEMV GQKMKYSIVS RNCEHFVAQL 120
RYGKSRCKQV EKAKVEVGVA TALGIL AG CSFAIRRYQK KATA 164
Seq ID NO 278 Protein Sequence
Protein Accession II NP_004687 l
1 11 21 31 41 51
I I I I I I
MLKREGKVQP YTKTLDGGWG WMIVIHFFLV NVFVMGMTKT FAIFFWFQE EFEGTSEQIG 60
WIGSIMSSLR FCAGPLVAII CDILGEKTTS ILGAFWTGG YLISSWATSI PFLCVTMGLL 120
PGLGSAFLYQ VAAWTTKYF KKRLALSTAI ARSGMGLTFL LAPFTKFLID LYDWTGALIL 180
FGAIALNLVP SSMLLRPIHI KSENNSGIKD KGSSLSAHGP EAHATETHCH ETEESTIKDS 240
TTQKAGLPSK NLTVSQNQSE EFYNGPNRNR LLLKSDEESD KVISWSCKQL FDISLFRNPF 300
FYIFTWSFLL SQLAYFIPTF HLVARAKTLG IDIMDASYLV SVAGILETVS QIISGWVADQ 360
NWIKKYHYHK SYLILCGITN LLAPLATTFP LLMTYTICFA IFAGGYLALI LPVLVDLCRN 420
STVNRFLGLA SFFAGMAVLS GPPIAGWLYD YTQTYNGSFY FSGICYLLSS VSFFFVPLAE 480
RWKNSLT 487
Seq ID NO 279 Protein Sequence
Protein Accession H NP_000349 1
1 11 21 31 41 51
I I I I I I
MALFVRLLAL ALALALGPAA TLAGPAKSPY QLVLQHSRLR GRQHGPNVCA VQKVIGTNRK 60
YFTNCKQWYQ RKICGKSTVI SYECCPGYEK VPGEKGCPAA LPLSNLYETL GWGSTTTQL 120
YTDRTEKLRP EMEGPGSFTI FAPSNEAWAS LPAEVLDSLV SNVNIELLNA LRYHMVGRRV 180
LTDELKHGMT LTSMYQNSNI QIHHYPNGIV TVNCARLLKA DHHATNGWH LIDKVISTIT 240
NNIQQIIEIE DTFETLRAAV AASGLNTMLE GNGQYTLLAP TNEAFEKIPS ETLNRILGDP 300
EALRDLLNNH ILKSAMCAEA IVAGLSVETL EGTTLEVGCS GDMLTINGKA IISNKDILAT 360
NGVIHYIDEL LIPDSAKTLF ELAAESDVST AIDLFRQAGL GNHLSGSERL TLLAPLNSVF 420
KDGTPPIDAH TRNLLRNHII KDQLASKYLY HGQTLETLGG KKLRVFVYRN SLCIENSCIA 480
AHDKRGRYGT LFTMDRVLTP PMGTVMDVLK GDNRFSMLVA AIQSAGLTET LNREGVYTVF 540
APTNEAFRAL PPRERSRLLG DAKELANILK YHIGDEILVS GGIGALVRLK SLQGDKLEVS 600
LKNNWSVNK EPVAEPDIMA TNGWHVITN VLQPPANRPQ ERGDELADSA LEIFKQASAF 660 SRASQRSVRL APVYQKLLER MKH 683
Seq ID NO 280 Protein Sequence Protein Accession tt NP_663623 1 11 21 31 41 51
I I I I I I
MEGSGGGAGE RAPLLGARRA AAAAAAAGAF AGRRAACGAV LLTELLERAA FYGITSNLVL 60
FLNGAPFCWE GAQASEALLL FMGLTYLGSP FGGWLADARL GRARAILLSL ALYLLGMLAF 120
PLLAAPATRA ALCGSARLLN CTAPGPDAAA RCCSPATFAG LVLVGLGVAT VKANITPFGA 180 DQVKDRGPEA TRRFFNWFYW SINLGAILSL GGIAYIQQNV SFVTGYAIPT VCVGLAFWF 240
LCGQSVFITK PPDGSAFTDM FKILTYSCCS QKRSGERQSN GEGIGVFQQS SKQSLFDSCK 300
MSHGGPFTEE KVEDVKALVK IVPVFLALIP YWTVYFQMQT TYVLQSLHLR IPEISNITTT 360
PHTLPAAWLT MFDAVLILLL IPLKDKLVDP ILRRHGLLPS SLKRIAVGMF FVMCSAFAAG 420
ILESKRLNLV KEKTINQTIG NWYHAADLS LWWQVPQYLL IGISEIFASI AGLEFAYSAA 480 PKSMQSAIMG LFFFFSGVGS FVGSGLLALV SIKAIGWMSS HTDFGNINGC YLNYYFFLLA 540
AIQGATLLLF LIISVKYDHH RDHQRSRANG VPTSRRA S77
Seq ID NO 281 Protein Sequence Protein Accession tt NP_001241 1 1 11 21 31 41 51
I I I I I I
MVRLPLQCVL WGCLLTAVHP EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL 60
PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV 120
LHRSCSPGFG VKQIATGVSD TICEPCPVGF FΞNVSSAFEK CHPWTSCETK DLWQQAGTN 180 KTDWCGPQD RLRALWIPI IFGILFAILL VLVFIKKVAK KPTNKAPHPK QEPQEINFPD 240
DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ 277
Seq ID NO 282 Protein Sequence
Protein Accession ft NP_003833 3
1 11 21 31 41 51
I I I I I I
MEQRGQNAPA ASGARKRHGP GPREARGARP GLRVPKTLVL WAAVLLLVS AESALITQQD 60
LAPQQRAAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD 120
SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH 180
KESGTKHSGE APAVEETVTS SPGTPASPCS LSGIIIGVTV AAWLIVAVF VCKSLLWKKV 240
LPYLKGICSG GGGDPERVDR SSQRPGAEDN VLNEIVSILQ PTQVPEQEME VQEPAEPTGV 300
NMLSPGESEH LLEPAEAERS QRRRLLVPAN EGDPTETLRQ CFDDFADLVP FDSWEPLMRK 360
LGLMDNEIKV AKAEAAGHRD TLYTMLIKWV NKTGRDΛSVH TLLDALETLG ERLAKQKIED 420
HLLSSGKFMY LEGNADSAMS 440
Seq ID NO 283 Protein Sequence
Protein Accession II NP_671716 1
1 11 21 31 41 51
I I I I I I
MEQRGQNAPA ASGARKRHGP GPREARGARP GLRVPKTLVL WAAVLLLVS AESALITQQD 60
LAPQQRAAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD 120
SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH 180
KESGIIIGVT VAAWLIVAV FVCKSLLWKK VLPYLKGICS GGGGDPERVD RSSQRPGAED 240
NVLNEIVSIL QPTQVPEQEM EVQEPAEPTG VNMLSPGESE HLLEPAEAER SQRRRLLVPA 300
NEGDPTETLR QCFDDFADLV PFDSWEPLMR KLGLMDNEIK VAKAEAAGHR DTLYTMLIKW 360
VNKTGRDASV HTLLDALETL GERLAKQKIE DHLLSSGKFM YLEGNADSAM S 411
Seq ID NO 284 Protein Sequence
Protein Accession ^ NP_002002 2
1 11 21 31 41 51
I I I I I I
MRLLLALLGV LLSVPGPPVL SLEASEEVEL EPCLAPSLEQ QEQELTVALG QPVRLCCGRA 60
ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS FLPEDAGRYL CLARGSMIVL QNLTLITGDS 120
LTSSNDDEDP KSHRDLSNRH SYPQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPTP 180 TIRWLKDGQA FHGENRIGGI RLRHQHWSLV MESWPSDRG TYTCLVENAV GSIRYNYLLD 240
VLERSPHRPI LQAGLPANTT AWGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP 300
YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPEEDPTWTA 360
AAPEARYTDI ILYASGSLAL AVLLLLAGLY RGQALHGRHP RPPATVQKLS RFPLARQFSL 420
ESGSSGKSSS SLVRGVRLSS SGPALLAGLV SLDLPLDPLW EFPRDRLVLG KPLGEGCFGQ 480
WRAEAFGMD PARPDQASTV AVKMLKDNAS DKDLADLVSE MEVMKLIGRH KNIINLLGVC 540
TQEGPLYVIV ECAAKGNLRE FLRARRPPGP DLSPDGPRSS EGPLSFPVLV SCAYQVARGM 600
QYLESRKCIH RDLAARNVLV TEDNVMKIAD FGLARGVHHI DYYKKTSNGR LPVKWMAPEA 660
LFDRVYTHQS DVWSFGILLW EIFTLGGSPY PGIPVEELFS LLREGHRMDR PPHCPPELYG 720
LMRECWHAAP SQRPTFKQLV EALDKVLLAV SEEYLDLRLT FGPYSPSGGD ASSTCSSSDS 780
VFSHDPLPLG SSSFPFGSGV QT 802
Seq ID NO 285 Protein Sequence
Protein Accession II NP_075252 1
1 11 21 31 41 51 I I I I I I
MRLLLALLGV LLSVPGPPVL SLEASEEVEL EPCLAPSLEQ QEQELTVALG QPVRLCCGRA 60
ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS FLPEDAGRYL CLARGSMIVL QNLTLITGDS 120
LTSSNDDEDP KSHRDLSNRH SYPQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPTP 180
TIRWLKDGQA FHGENRIGGI RLRHQHWSLV MESWPSDRG TYTCLVENAV GSIRYNYLLD 240 VLERSPHRPI LQAGLPANTT AWGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP 300
YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPGTGRIPHL 360
TCDSLTPAGR TKSPTLQFSL ESGSSGKSSS SLVRGVRLSS SGPALLAGLV SLDLPLDPLW 420
EFPRDRLVLG KPLGEGCFGQ WRAEAFGMD PARPDQASTV AVKMLKDNAS DKDLADLVSE 480
MEVMKLIGRH KNIINLLGVC TQEGPLYVIV ECAAKGNLRE FLRARRPPGP DLSPDGPRSS 540 EGPLSFPVLV SCAYQVARGM QYLESRKCIH RDLAARNVLV TEDNVMKIAD FGLARGVHHI 600
DYYKKTSNGR LPVKWMAPEA LFDRVYTHQS DVWSFGILLW EI FTLGGSPY PGI PVEELFS 660
LLREGHRMDR PPHCPPELYG LMRECWHAAP SQRPTFKQLV EALDKVLLAV SEEYLDLRLT 720
FGPYSPSGGD ASSTCSSSDS VFSHDPLPLG SSSFPFGSGV QT 762
Seq ID NO 286 Protein Sequence
Protein Accession ft NP_002836 2
1 11 21 31 41 51
I I I I I I
MRGLGTCLAT LAGLLLTAAG ETFSGGCLFD EPYSTCGYSQ SEGDDFNWEQ VNTLTKPTSD 60
PWMPSGSLML VNASGRPEGQ RAHLLLPQLK ENDTHCIDFH YFVSSKSNSP PGLLNVYVKV 120
NNGPLGNPIW NISGDPTRTW NRAELAISTF WPNFYQVIFE VITSGHQGYL AIDEVKVLGH 180
PCTRTPHFLR IQNVEVNAGQ FATFQCSAIG RTVAGDRLWL QGIDVRDAPL KEIKVTSSRR 240
FIASFNWNT TKRDAGKYRC MIRTEGGVGI SNYAELWKE PPVPIAPPQL ASVGATYLWI 300
QLNANSINGD GPIVAREVEY CTASGSWNDR QPVDSTSYKI GHLDPDTEYE ISVLLTRPGE 360
GGTGSPGPAL RTRTKCADPM RGPRKLEWE VKSRQITIRW EPFGYNVTRC HSYNLTVHYC 420
YQVGGQEQVR EEVSWDTENS HPQHTITNLS PYTNVSVKLI LMNPEGRKES QELIVQTDED 480
LPGAVPTESI QGSTFEEKI F LQWREPTQTY GVITLYEITY KAVSSFDPEI DLSNQSGRVS 540
KLGNETHFLF FGLYPGTTYS FTIRASTAKG FGPPATNQFT TKISAPSMPA YELETPLNQT 600
DNTVTVMLKP AHSRGAPVSV YQIWEEERP RRTKKTTEIL KCYPVPIHFQ NASLLNSQYY 660
FAAEFPADSL QAAQPFTIGD NKTYNGYWNT PLLPYKSYRI YFQAASRANG ETKIDCVQVA 720
TKGAATPKPV PEPEKQTDHT VKIAGVIAGI LLFVI IFLGV VLVMKKRKLA KKRKETMSST 780
RQEMTVMVNS MDKSYAEQGT NCDEAFSFMD THNLNGRSVS SPSSFTMKTN TLSTSVPNSY 840
YPDETHTMAS DTSSLVQSHT YKKREPADVP YQTGQLHPAI RVADLLQHIT QMKCAEGYGF 900 KEEYESFFEG QSAPWDSAKK DENRMKNRYG NI IAYDHSRV RLQTIEGDTN SDYINGNY1D 960
GYHRPNHYIA TQGPMQETIY DFWRMVWHEN TASI IMVTNL VEVGRVKCCK YWPDDTEIYK 1020
DIKVTLIETE LLAEYVIRTF AVEKRGVHEI REIRQFHFTG WPDHGVPYHA TGLLGFVRQV 1080
KSKSPPSAGP LWHCSAGAG RTGCFIVIDI MLDMAEREGV VDIYNCVREL RSRRVNMVQT 1140
EEQYVFIHDA ILEACLCGDT SVPASQVRSL YYDMNKLDPQ TNSSQIKEEF RTLNMVTPTL 1200 RVEDCSIALL PRNHEKNRCM DILPPDRCLP FLITIDGESS NYINAALMDS YKQPSAFIVT 1260
QHPLPNTVKD FWRLVLDYHC TS MLNDVD PAQLCPQYWP ENGVHRHGPI QVEFVSADLE 1320
EDI ISRIFRI YNAARPQDGY RMVQQFQFLG WPMYRDTPVS KRSFLKLIRQ VDKWQEEYNG 1380
GEGPTWHCL NGGGRSGTFC AISIVCEMLR HQRTVDVFHA VKTLRNNKPN MVDLLDQYKF 1440
CYEVALEYLN SG 1452
Seq ID NO 287 Protein Sequence
Protein Accession ft NP_057635 1
1 11 21 31 41 51
M IGFLQLLWA VILASEHRVAG AIAEVFGNSSE GILIEFSVGKF RIYFELNRPFP EIEAILHDI SS 60
NVTFLIFQIH SQYQNTTVSF SPTLLSNSSE TGTASGLVFI LRPEQSTCTW YLGTSGIQPV 120
QNMAILLSYS ERDPVPGGCN LEFDLDIDPN IYLEYNFFET TIKFAPANLG YARGVDPPPC 180
DAGTDQDSRW RLQYDVYQYF LPENDLTEEM LLKHLQRMVS VPQVKASALK WTLTANDKT 240
SVSFSSLPGQ GVIYNVIVWD PFLNTSAAYI PAHTYACSFE AGEGSCASLG RVSSKVFFTL 300
FALLGFFICF FGHRFWKTEL FFIGFI IMGF FFYILITRLT PIKYDVNLIL TAVTGSVGGM 360
FLVAVWWRFG ILSICMLCVG LVLGFLISSV TFFTPLGNLK I FHDDGVFWV TFSCIAILI P 420
WFMGCLRIL NILTCGVIGS YSWLAIDSY WSTSLSYITL NVLKRALNKD FHRAFTNVPF 480
QTNDFI ILAV WGMLAVSGIT LQIRRERGRP FFPPHPYKLW KQERERRVTN ILDPSYHI PP 540
LRERLYGRLT QIKGLFQKEQ PAGERTPLLL 570
Seq ID NO 288 Protein Sequence
Protein Accession II NP_003811 1
1 11 21 31 41 51
I I I I I I
MEPPGDWGPP PWRSTPRTDV LRLVLYLTFL GAPCYAPALP SCKEDEYPVG SECCPKCSPG 60
YRVKEACGEL TGTVCEPCPP GTYIAHLNGL SKCLQCQMCD PAMGLRASRN CSRTENAVCG 120
CSPGHFCIVQ DGDHCAACRA YATSSPGQRV QKGGTESQDT LCQNCPPGTF SPNGTLEECQ 180
HQTKCSWLVT KAGAGTSSSH WVWWFLSGSL VIVIVCSTVG LIICVKRRKP RGDWKVIVS 240
VQRKRQEAEG EATVIEALQA PPDVTTVAVE ETIPSFTGRS PNH 283
Seq ID NO 289 Protein Sequence
Protein Accession tt NP_000943 1
1 11 21 31 41 51
M IEPHDSSHMD SIEFRYTLFPI VIYSIIFVLGV IIANGYVLWVF AIRLYPCKKFN EIIKIFMVNLT 60
MADMLFLITL PLWIVYYQNQ GNWILPKFLC NVAGCLFFIN TYCSVAFLGV ITYNRFQAVT 120
RPIKTAQANT RKRGISLSLV IWVAIVGAAS YFLILDSTNT VPDSAGSGNV TRCFEHYEKG 180
SVPVLIIHIF IVFSFFLVFL IILFCNLVII RTLLMQPVQQ QRNAEVKRRA LWMVCTVLAV 240
FIICFVPHHV VQLPWTLAEL GFQDSKFHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF 300
RKHLTEKFYΞ MRSSRKCSRA TTDTVTEVW PFNQIPGNSL KN 342
Seq ID NO 290 Protein Sequence Protein Accession ff NP_003262 1
1 11 21 31 41 51 I I I I I I
GCLGAIKENK CLLLTFFLLL LLVFLLEATI AILFFAYTDK IDRYAQQDLK KGLHLYGTQG 60 NVGLTNAWSI IQTDFRCCGV SNYTDWFEVY NATRVPDSCC LEFSESCGLH APGTWWKAPC 120 YETVKVWLQE NLLAVGIFGL CTALVQILGL TFAMTMYCQV VKADTYCA 168
Seq ID NO 291 Protein Sequence
Protein Accession ft NP_005620 1
1 11 21 31 41 51
M IAKKSAENGI YISVSGDEKKG PILIAPGPDGA PIAKGDGPVGL GITPGGRLAVP PIRETWTRQMD FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV GGIPIFFLEI SLGQFMKAGS 120
INVWNICPLF KGLGYASMVI VFYCNTYYIM VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD 180
CVEIFRHEDC ANASLANLTC DQLADRRSPV IEFWENKVLR LSGGLEVPGA LNWEVTLCLL 240
ACWVLVYFCV WKGVKSTGKI VYFTATFPYV VLWLLVRGV LLPGALDGII YYLKPDWSKL 300
5 GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG TSFFAGF F 360
SILGFMAAEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP LWAALFFFML LLLGLDSQFV 420
GVEGFITGLL DLLPASYYFR FQREISVALC CALCFVIDLS MVTDGGMYVF QLFDYYSASG 480
TTLLWQAFWE CVWAWVYGA DRFMDDIACM IGYRPCPWMK WCWSFFTPLV CMGIFIFNW 540
YYEPLVYNNT YVYPWWGEAM GWAFALSSML CVPLHLLGCL LRAKGTMAER WQHLTQPIWG 600
10 LHHLEYRAQD ADVRGLTTLT PVSESSKVW VESVM 635
Seq ID NO 292 Protein Sequence
Protein Accession β: NP_037464.1
1 11 21 31 41 51
15 I I I I I I
MKHVLNLYLL GWLTLLSIF VRVMESLEGL LESPSPGTSW TTRSQLANTE PTKGLPDHPS 60 RSM 63
Seq ID NO: 293 Protein Sequence
20 Protein Accession tt ■ NP_064527.l
1 11 21 31 41 51
I I I I I I
MAGASLGARF YRQIKRHPGI IPMIGLICLG MGSAALYLLR LALRSPDVCW DRKNNPEPWN 60 RLSPNDQYKF LAVSTDYKKL KKDRPDF 87
25
Seq ID NO: 294 Protein Sequence
Protein Accession ft: NP_002195.1
1 11 21 31 41 51
,Λ I I I I I I
JV MGPGPSRAPR APRLMLCALA LMVAAGGCW SAFNLDTRFL KEAGNPGS LFGYSVALHR 60
QTERQQRYLL LAGAPRELAV PDGYTNRTGA VYLCPLTAHK DDCERMNITV KNDPGHHIIE 120
DMWLGVTVAS QGPAGRVLVC AHRYTQVLWS GSEDQRRMVG KCYVRGNDLE LDSSDDWQTY 180
HNEMCNSNTD YLETGMCQLG TSGGFTQNTV YFGAPGAYNW KGNSYMIQRK EWDLSEYSYK 240
DPEDQGNLYI GYTMQVGSFI LHPKNITIVT GAPRHRHMGA VFLLSQEAGG DLRRRQVLEG 300
35 SQVGAYFGSA IALADLNNDG WQDLLVGAPY YFERKEEVGG AIYVFMNQAG TSFPAHPSLL 360
LHGPSGSAFG LSVASIGDIN QDGFQDIAVG APFEGLGKVY IYHSSSKGLL RQPQQVIHGE 420
KLGLPGLATF GYSLSGQMDV DENFYPDLLV GSLSDHIVLL RARPVINIVH KTLVPRPAVL 480
DPALCTATSC VQVELCFAYN QSAGNPNYRR NITLAYTLEA DRDRRPPRLR FAGSESAVFH 540
GFFSMPEMRC QKLELLLMDN LRDKLRPIII SMNYSLPLRM PDRPRLGLRS LDAYPILNQA 600
40 QALENHTEVQ FQKECGPDNK CESNLQMRAA FVSEQQQKLS RLQYSRDVRK LLLSINVTNT 660
RTSERSGEDA HEALLTLWP PALLLSSVRP PGACQANETI FCELGNPFKR NQRMELLIAF 720
EVIGVTLHTR DLQVQLQLST SSHQDNLWPM ILTLLVDYTL QTSLSMVNHR LQSFFGGTVM 780
GESGMKTVED VGSPLKYEFQ VGPMGEGLVG LGTLVLGLEW PYEVSNGKWL LYPTEITVHG 840
NGSWPCRPPG DLINPLNLTL SDPGDRPSSP QRRRRQLDPG GGQGPPPVTL AAAKKAKSET 900
45 VLTCATGRAH CVWLECPIPD APWTNVTVK ARVWNSTFIE DYRDFDRVRV NGWATLFLRT 960
SIPTINMENK TTWFSVDIDS ELVEELPAEI ELWLVLVAVG AGLLLLGLII LLLWKCGFFK 1020
RARTRALYEA KRQKAEMKSQ PSETERLTDD Y 1051
Seq ID NO: 295 Protein Sequence
50 Protein Accession tt NP_005492.1
1 11 21 31 41 51
I I I I I I
MGPGPSRAPR APRLMLCALA LMVAAGGCW SAFNLDTRFL WKEAGNPGS LFGYSVALHR 60
QTERQQRYLL LAGAPRELAV PDGYTNRTGA VYLCPLTAHK DDCERMNITV KNDPGHHIIE 120
55 DMWLGVTVAS QGPAGRVLVC AHRYTQVLWS GSEDQRRMVG KCYVRGNDLE LDSSDDWQTY 180
HNEMCNSNTD YLETGMCQLG TSGGFTQNTV YFGAPGAYNW KGNSYMIQRK EWDLSEYSYK 240
DPEDQGNLYI GYTMQVGSFI LHPKNITIVT GAPRHRHMGA VFLLSQEAGG DLRRRQVLEG 300
SQVGAYFGSA IALADLNNDG WQDLLVGAPY YFERKEEVGG AIYVFMNQAG TSFPAHPSLL 360
LHGPSGSAFG LSVASIGDIN QDGFQDIAVG APFEGLGKVY IYHSSSKGLL RQPQQVIHGE 420
60 KLGLPGLATF GYSLSGQMDV DENFYPDLLV GSLSDHIVLL RARPVINIVH KTLVPRPAVL 480
DPALCTATSC VQVELCFAYN QSAGNPNYRR NITLAYTLEA DRDRRPPRLR FAGSESAVFH 540
GFFSMPEMRC QKLELLLMDN LRDKLRPIII SMNYSLPLRM PDRPRLGLRS LDAYPILNQA 600
QALENHTEVQ FQKECGPDNK CESNLQMRAA FVSEQQQKLS RLQYSRDVRK LLLSINVTNT 660
RTSERSGEDA HEALLTLWP PALLLSSVRP PGACQANETI FCELGNPFKR NQRMELLIAF 720
65 EVIGVTLHTR DLQVQLQLST SSHQDNLWPM ILTLLVDYTL QTSLSMVNHR LQSFFGGTVM 780
GESGMKTVED VGSPLKYEFQ VGPMGEGLVG LGTLVLGLEW PYEVSNGKWL LYPTEITVHG 840
NGSWPCRPPG DLINPLNLTL SDPGDRPSSP QRRRRQLDPG GGQGPPPVTL AAAKKAKSET 900
VLTCATGRAH CVWLECPIPD APWTNVTVK ARVWNSTFIE DYRDFDRVRV NGWATLFLRT 960
SIPTINMENK TTWFSVDIDS ELVEELPAEI ELWLVLVAVG AGLLLLGLII LLLWKCDFFK 1020
70 RTRYYQIMPK YHAVRIREEE RYPPPGSTLP TKKHWVTSWQ TRDQYY 1066
Seq ID NO: 296 Protein Sequence Protein Accession It: NP_003777
1 11 21 31 41 51
75 I I I I I I
MDALCGSGEL GSKFWDSNLS VHTENPDLTP CFQNSLLAWV PCIYLWVALP CYLLYLRHHC 60
RGYIILSHLS KLKMVLGVLL WCVSWADLFY SFHGLVHGRA PAPVFFVTPL WGVTMLLAT 120
LLIQYERLQG VQSSGVLIIF WFLCWCAIV PFRSKILLAK AEGEISDPFR FTTFYIHFAL 180
VLSALILACF REKPPFFSAK NVDPNPYPET SAGFLSRLFF WWFTKMAIYG YRHPLEEKDL 240
80 WSLKEEDRSQ M QQLLEAW RKQEKQTARH KASAAPGKNA SGEDEVLLGA RPRPRKPSFL 300
KALLATFGSS FLISACFKLI QDLLSFINPQ LLSILIRFIS NPMAPSWWGF LVAGLMFLCS 360
MMQSLILQHY YHYIFVTGVK FRTGIMGVIY RKALVITNSV KRASTVGEIV NLMSVDAQRF 420
MDLAPFLNLL WSAPLQIILA IYFLWQNLGP SVLAGVAFMV LLIPLNGAVA VKMRAFQVKQ 480
MKLKDSRIKL MSEILNGIKV LKLYAWEPSF LKQVEGIRQG ELQLLRTAAY LHTTTTFTWM 540 CSPFLVTLIT LWVYVYVDPN NVLDAEKAFV SVSLFNILRL PLNMLPQLIS NLTQASVSLK 600
RIQQFLSQEE LDPQSVERKT ISPGYAITIH SGTFTWAQDL PPTLHSLDIQ VPKGALVAW 660
GPVGCGKSSL VSALLGEMEK LEGKVHMKGS VAYVPQQAWI QNCTLQENVL FGKALNPKRY 720
QQTLEACALL ADLEMLPGGD QTEIGEKGIN LSGGQRQRVS LARAVYSDAD IFLLDDPLSA 780
VDSHVAKHIF DHVIGPEGVL AGKTRVLVTH GISFLPQTDF IIVLADGQVS EMGPYPALLQ 840
RNGSFANFLC NYAPDEDQGH LEDSWTALEG AEDKEALLIE DTLSNHTDLT DNDPVTYWQ 900
KQFMRQLSAL ΞSDGEGQGRP VPRRHLGPSE KVQVTEAKAD GALTQEEKAA IGTVELSVFW 960
DYAKAVGLCT TLAICLLYVG QSAAAIGANV WLSAWTNDAM ADSRQNNTSL RLGVYAALGI 1020
LQGFLVMLAA MAMAAGGIQA ARVLHQALLH NKIRSPQSFF DTTPSGRILN CFSKDIYWD 1080
EVLAPVILML LNSFFNAIST LWIMASTPL FTWILPLAV LYTLVQRFYA ATSRQLKRLE 1140
SVSRSPIYSH FSETVTGASV IRAYNRSRDF EIISDTKVDA NQRSCYPYII SNRWLSIGVE 1200
FVGNCWLFA ALFAVIGRSS LNPGLVGLSV SYSLQVTFAL NWMIRMMSDL ESNIVAVERV 1260
KEYSKTETEA PWWEGSRPP EGWPPRGEVE FRNYSVRYRP GLDLVLRDLS LHVHGGEKVG 1320
IVGRTGAGKS SMTLCLFRIL EAAKGEIRID GLNVADIGLH DLRSQLTIIP QDPILFSGTL 1380
RMNLDPFGSY SEEDIWWALE LSHLHTFVSS QPAGLDFQCS EGGENLSVGQ RQLVCLARAL 1440
LRKSRILVLD EATAAIDLET DNLIQATIRT QFDTCTVLTI AHRLNTIMDY TRVLVLDKGV 1500
VAEFDSPANL IAARGIFYGM ARDAGLA 1527
Seq ID NO 297 Protein Sequence
Protein Accession it NP_002692 1
1 11 21 31 41 51
I I I I I I
MHFYRLFLGA TRRFLNPEWK GEIDNWCVYV LTSLLPFKIQ SQDIKALQKE LEQFAKLLKQ 60
KRITLGYTQA DVGLTLGVLF GKVFSQTTIC RFEALQLSFK NMCKLRPLLQ KWVEEADNNE 120
NLQEICKAET LVQARKRKRT SIENRVRGNL ENLFLQCPKP TLQQISHIAQ QLGLEKDWR 180
VWFCNRRQKG KRSSSDYAQR EDFEAAGSPF SGGPVSFPLA PGPHFGAPGY GSPHFTALYS 240
SVPFPEGEAF PPVSVTTLGS PLHSN 265
Seq ID NO 298 Protein Sequence
Protein Accession II NP_005449 1
1 11 21 31 41 51
I I I I I I
MASPRRSGQP GRPPPPPPPP ARLLLLLLLP LLLPLAPGAW GWARGAPRPP PSSPPLSIMG 60
LMPLTKEVAK GSIGRGVLPA VELAIEQIRN ESLLRPYFLD LRLYDTECDN AKGLKAFYDA 120
IKYGPNHLMV FGGVCPSVTS IIAESLQGWN LVQLSFAATT PVLADKKKYP YFFRTVPSDN 180
AVNPAILKLL KHYQWKRVGT LTQDVQRFSE VRNDLTGVLY GEDIEISDTE SFSNDPCTSV 240
KKLKGNDVRI ILGQFDQNMA AKVFCCAYEE NMYGSKYQWI IPGWYEPSWW EQVHTEANSS 300
RCLRKNLLAA MEGYIGVDFE PLSSKQIKTI SGKTPQQYER EYNNKRSGVG PSKFHGYAYD 360
GIWVIAKTLQ RAMETLHASS RHQRIQDFNY TDHTLGRIIL NAMNETNFFG VTGQWFRNG 420
ERMGTIKFTQ FQDSREVKVG EYNAVADTLE IINDTIRFQG SEPPKDKTII LEQLRKISLP 480
LYSILSALTI LGMIMASAFL FFNIKNRNQK LIKMSSPYMN NLIILGGMLS YASIFLFGLD 540
GSFVSEKTFE TLCTVRTWIL TVGYTTAFGA MFAKTWRVHA IFKNVKMKKK IIKDQKLLVI 600
VGGMLLIDLC ILICWQAVDP LRRTVEKYSM EPDPAGRDIS IRPLLEHCEN THMTIWLGIV 660
YAYKGLLMLF GCFLAWETRN VSIPALNDSK YIGMSVYNVG IMCIIGAAVS FLTRDQPNVQ 720
FCIVALVIIF CSTITLCLVF VPKLITLRTN PDAATQNRRF QFTQNQKKED SKTSTSVTSV 780
NQASTSRLEG LQSENHRLRM KITELDKDLE EVTMQLQDTP EKTTYIKQNH YQELNDILNL 840
GNFTESTDGG KAILKNHLDQ NPQLQWNTTE PSRTCKDPIE DINSPEHIQR RLSLQLPILH 900
HAYLPSIGGV DASCVSPCVS PTASPRHRHV PPSFRVMVSG L 941
Seq ID NO 299 Protein Sequence
Protein Accession II NP_055632
1 11 21 31 41 51
I I I I I I
MEAARALRLL LWCGCLALP PLAEPVCPER CDCQHPQHLL CTNRGLRWP KTSSLPSPHD 60
VLTYSLGGNF ITNITAFDFH RLGQLRRLDL QYNQIRSLHP KTFEKLSRLE ELYLGNNLLQ 120
ALAPGTLAPL RKLRILYANG NEISRLSRGS FEGLESLVKL RLDGNALGAL PDAVFAPLGN 180
LLYLHLESNR IRFLGKNAFA QLGKLRFLNL SANELQPSLR HAATFAPLRS LSSLILSANS 240
LQHLGPRIFQ HLPRLGLLSL RGNQLTHLAP EAFWGLEALR ELRLEGNRLS QLPTALLEPL 300
HSLEALDLSG NELSALHPAT FGHLGRLREL SLRNNALSAL SGDIFAASPA LYRLDLDGNG 360
WTCDCRLRGL KRWMGDWHSQ GRLLTVFVQC RHPPALRGKY LDYLDDQQLQ NGSCADPSPS 420
ASLTADRRRQ PLPTAAGEEM TPPAGLAEEL PPQPQLQQQG RFLAGVAWDG AARELVGNRS 480
ALRLSRRGPG LQQPSPSVAA AAGPAPQSLD LHKKPQRGRP TRADPALAEP TPTASPGSAP 540
SPAGDPWQRA TKHRLGTEHQ ERAAQSDGGA GLPPLVSDPC DFNKFILCNL TVEAVGADSA 600
SVRWAVREHR SPRPLGGARF RLLFDRFGQQ PKFHRFVYLP ESSDSATLRE LRGDTPYLVC 660
VEGVLGGRVC PVAPRDHCAG LVTLPEAGSR GGVDYQLLTL ALLTVNALLV LLALAAWASR 720
WLRRKLRARR KGGAPVHVRH MYSTRRPLRS MGTGVSADFS GFQSHRPRTT VCALSEADLI 780
EFPCDRFMDS AGGGAGGSLR REDRLLQRFA D 811
Seq ID NO 300 Protein Sequence
Protein Accession # NP_001783 2
1 11 21 31 41 51
I I I I I I
MCRIAGALRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH EGQPLLNVKF 60
SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA KFLIYAQDKE TQEKWQVAVK 120 LSLKPTLTEE SVKESAEVEE IVFPRQFSKH SGHLQRQKRD WVIPPINLPE NSRGPFPQEL 180
VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV 240
DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL 300
NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY 360
GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDIIV ANLTVTDKDQ PHTPAWNAVY 420
RISGGDPTGR FAIQTDPNSN DGLVTWKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS 480
TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP 540
ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 600
NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTITRLNGD 660
FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL 720 GTGAIIAILL CIIILLILVL MFWWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE 780
EDQDYDLSQL QQPDTVEPDA IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL 840
KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM 900
YGGGDD 906
Seq ID NO 301 Protein Sequence
Protein Accession ft- NP_058637.1
1 11 21 31 41 51
10 I I I I I I
MVSPRMSGLL SQTVILALIF LPQTRPAGVF ELQIHSFGPG PGPGAPRSPC SARLPCRLFF 60
RVCLKPGLSE EAAESPCALG AALSARGPVY TEQPGAPAPD LPLPDGLLQV PFRDAWPGTF 120
SFIIETWREE LGDQIGGPAW SLLARVAGRR RLAAGGPWAR DIQRAGAWEL RFSYRARCEP 180
PAVGTACTRL CRPRSAPSRC GPGLRPCAPL EDECEAPLVC RAGCSPEHGF CEQPGECRCL 240
EGWTGPLCTV PVSTSSCLSP RGPSSATTGC LVPGPGPCDG NPCANGGSCS ETPRSFECTC 300
15 PRGFYGLRCE VSGVTCADGP CFNGGLCVGG ADPDSAYICH CPPGFQGSNC EKRVDRCSLQ 360
PCRNGGLCLD LGHALRCRCR AGFAGPRCEH DLDDCAGRAC ANGGTCVEGG GAHRCSCALG 420
FGGRDCRERA DPCAARPCAH GGRCYAHFSG LVCACAPGYM GARCEFPVHP DGASALPAAP 480
PGLRPGDPQR YLLPPALGLL VAAGVAGAAL LLVHVRRRGH SQDAGSRLLA GTPEPSVHAL 540
PDALNNLRTQ EGSGDGPSSS VDWNRPEDVD PQGIYVISAP SIYAREVATP LFPPLHTGRA 600
20 GQRQHLLFPY PSSILSVK 618
Seq ID NO: 302 Protein Sequence Protein Accession it : fgenes prediction -_ 1 11 21 31 41 51
25 I I I I I I
MCQAFLWVLG TLWLLKNARC LQPYPPEHAQ SCLISEAKQG QAQLPLGWVK WPLHLRSSLS 60 KRLERKYPSL LNGEIEAQIC KTSSLELPSC DLVTADGSTE VTISENLPAV GFHICQQQDS 120 HVEGMVNISK ASSGQM 136
30 Seq ID NO: 303 Protein Sequence Protein Accession ft: NP_079088 1 1 11 21 31 41 51
I I I I I I
MGCGGSRADA IEPRYYESWT RETESTWLTY TDSDAPPSAA APDSGPEAGG LHSGMLEDGL 60 35 PSNGVPRSTA PGGIPNPEKK TNCETQCPNP QSLSSGPLTQ KQNGLQTTEA KRDAKRMPAK 120 EVTINVTDSI QQMDRSRRIT KNCVN 145
Seq ID NO: 304 Protein Sequence
Protein Accession ft: XP_040550.1
40 1 11 21 31 41 51
I I I I I I
MGADGETWL KNMLIGINLI LLGΞMIKPSE CQLEVTTERV QRQSVEEEGG IANYNTSSKE 60
QPWFNHVYN INVPLDNLCS SGLEASAEQE VSAEDETLAE YMGQTSDHES QVTFTHRINF 120
PKKACPCASS AQVLQELLSR IEMLEREVSV LRDQCNANCC QESAATGQLD YIPHCSGHGN 180
45 FSFESCGCIC NEGWFGKNCS EPYCPLGCSS RGVCVDGQCI CDSEYSGDDC SELRCPTDCS 240
SRGLCVDGEC VCEEPYTGED CRELRCPGDC SGKGRCANGT CLCEEGYVGE DCGQRQCLNA 300
CSGRGQCEEG LCVCEEGYQG PDCSAVAPPE DLRVAGISDR SIELEWDGPM AVTEYVISYQ 360
PTALGGLQLQ QRVPGDWSGV TITELEPGLT YNISVYAVIS NILSLPITAK VATHLSTPQG 420
LQFKTITETT VEVQWEPFSF SFDGWEISFI PKNNEGGVIA QVPSDVTSFN QTGLKPGEEY 480
50 IVNWALKEQ ARSPPTSASV STVIDGPTQI LVRDVSDTVA FVEWIPPRAK VDFILLKYGL 540
VGGEGGRTTF RLQPPLSQYS VQALRPGSRY EVSVSAVRGT NESDSATTQF TTEIDAPKNL 600
RVGSRTATSL DLEWDNSEAE VQEYKWYST LAGEQYHEVL VPRGIGPTTR ATLTDLVPGT 660
EYGVGISAVM NSQQSVPATM NARTELDSPR DLMVTASSET SISLIWTKAS GPIDHYRITF 720
TPSSGIASEV TVPKDRTSYT LTDLEPGAEY IISVTAERGR QQSLESTVDA FTGFRPISHL 780
55 HFSHVTSSSV NITWSDPSPP ADRLILNYSP RDEEEEMMEV SLDATKRHAV LMGLQPATEY 840
IVNLVAVHGT VTSEPIVGSI TTGIDPPKDI TISNVTKDSV MVSWSPPVAS FDYYRVSYRP 900
TQVGRLDSSV VPNTVTEFTI TRLNPATEYE ISLNSVRGRE ESERICTLVH TAMDNPVDLI 960
ATNITPTEAL LQWKAPVGEV ENYVIVLTHF AVAGETILVD GVSEEFRLVD LLPSTHYTAT 1020
MYATNGPLTS GTISTNFSTL LDPPANLTAS EVTRQSALIS WQPPRAEIEN YVLTYKSTDG 1080
60 SRKELIVDAE DTWIRLEGLL ENTDYTVLLQ AAQDTTWSSI TSTAFTTGGR VFPHPQDCAQ 1140
HLMNGDTLSG VYPIFLNGEL SQKLQVYCDM TTDGGGWIVF QRRQNGQTDF FRKWADYRVG 1200
FGNVEDEFWL GLDNIHRITS QGRYELRVDM RDGQEAAFAS YDRFSVEDSR NLYKLRIGSY 1260
NGTAGDSLSY HQGRPFSTED RDNDVAVTNC AMSYKGAWWY KNCHRTNLNG KYGESRHSQG 1320
INWYHWKGHE FSIPFVEMKM RPYNHRLMAG RKRQSLQF 1358
65
Seq ID NO: 305 Protein Sequence
Protein Accession ft: NP_005874.1
1 11 21 31 41 51
I I I I I I
70 MASSVAPYEQ LVRQVEALKA ENSHLRQELR DNSSHLSKLE TETSGMKEVL KHLQGKLEQE 60
ARVLVSSGQT EVLEQLKALQ MDITSLYNLK FQPPTLGPEP AARTPEGSPV HGSGPSKDSF 120
GELSRATIRL LEELDRERCF LLNEIEKEEK EKLWYYSQLQ GLSKRLDELP HVETQFSMQM 180
DLIRQQLEFE AQHIRSLMEE RFGTSDEMVQ RAQIRASRLE QIDKELLEAQ DRVQQTEPQA 240
LLAVKSVPVD EDPETEVPTH PEDGTPQPGN SKVEWFWLL SMLATRDQED TARTLLAMSS 300
75 SPESCVAMRR SGCLPLLLQI LHGTEAAAGG RAGAPGAPGA KDARMRANAA LHNIVFSQPD 360
QGLARKEMRV LHVLEQIRAY CETCWDWLQA RDGGPEGGGA GSAPIPIEPQ ICQATCAVMK 420
LSFDEEYRRA MNELGGLQAV AELLQVDYEM HKMTRDPLNL ALRRYAGMTL TNLTFGDVAN 480
KATLCARRGC MEAIVAQLAS DSEELHQ S SILRNLSWRA DINSKKVLRE AGSVTALVQC 540
VLRATKESTL KSVLSALWNL SAHSTENKAA ICQVDGALGF LVSTLTYKCQ SNSLAIIESG 600
80 GGILRNVSSL VATREDYRQV LRDHNCLQTL LQHLTSHSLT IVSNACGTLW NLSARSARDQ 660
ELLWDLGAVG MLRNLVHSKH KMIAMGSAAA LRNLLAHRPA KHQAAATAVS PGSCVPSLYV 720
RKQRALEAEL DARHLAQALE HLEKQGPPAA EAATKKPLPP LRHLDGLAQD YASDSGCFDD 780
DDAPSSLAAA AATGEPASPA ALSLFLGSPF LQGQALARTP PTRRGGKEAE KDTSGEAAVA 840
AKAKAKLALA VARIDQLVED ISALHTSSDD SFSLSSGDPG QEAPREGRAQ SCSPCRGPEG 900 GRREAGSRAH PLLRLKAAHA SLSNDSLNSG SASDGYCPRE HMLPCPLAAL ASRREDPRCG 960
QPRPSRLDLD LPGCQAEPPA REATSADARV RTIKLSPTYQ HVPLLEGASR AGAEPLAGPG 1020
ISPGARKQAW LPADHLSKVP EKLAAAPLSV ASKALQKLAA QEGPLSLSRC SSLSSLSSAG 1080
RPGPΞEGGDL DDSDSSLEGL EEAGPSEAEL DSTWRAPGAT SLPVAIPAPR RNRGRGLGVE 1140 DATPSSSSEN YVQETPLVLS RCSSVΞSLGS FESPSIASSI PΞEPCSGQGS GTISPSELPD 1200
SPGQTMPPSR SKTPPLAPAP QGPPEATQFS LQWESYVKRF LDIADCRERC RLPSELDAGS 1260
VRFTVEKPDE NFSCASSLSA LALHEHYVQQ DVELRLLPSA CPERGGGAGG AGLHFAGHRR 1320
REEGPAPTGS RPRGAADQEL ELLRECLGAA VPARLRKVAS ALVPGRRALP VPVYMLVPAP 1380
APAQEDDSCT DΞAEGTPVNF SSAASLSDET LQGPPRDQPG GPAGRQRPTG RPTSARQAMG 1440 HRHKAGGAGR SAEQSRGAGK NRAGLELPLG RPPSAPADKD GSKPGRTRGD GALQSLCLTT 1500
PTEEAVYCFY GNDSDEEPPA AAPTPTHRRT SAIPRAFTRE RPQGRKEAPA PSKAAPAAPP 1560
PARTQPSLIA DETPPCYSLS SSASSLSEPE PSEPPAVHPR GREPAVTKDP GPGGGRDSSP 1620
SPRAAEELLQ RCISSALPRR RPPVSGLRRR KPRATRLDER PAEGSRERGE EAAGSDRASD 1680
LDSVEWRAIQ EGANSIVTWL HQAAAATREA SSESDSILSF VSGLSVGSTL QPPKHRKGRQ 1740 AEGEMGSARR PEKRGAASVK TSGSPRSPAG PEKPRGTQKT TPGVPAVLRG RTVIYVPSPA 1800
PRAQPKGTPG PRATPRKVAP PCLAQPAAPA KVPSPGQQRS RSLHRPAKTS ELATLSQPPR 1860
SATPPARLAK TPSSSSSQTS PASQPLPRKR PPVTQAAGAL PGPGASPVPK TPARTLLAKQ 1920
HKTQRSPVRI PFMQRPARRG PPPLARAVPE PGPRGRAGTE AGPGARGGRL GLVRVASALS 1980
SGSESSDRSG FRRQLTFIKE SPGLRRRRSE LSSAESAASA PQGASPRRGR PALPAVFLCS 2040 SRCEELRAAP RQGPAPARQR PPAARPSPGE RPARRTTSES PSRLPVRAPA ARPETVKRYA 2100
SLPHISVARR PDGAVPAAPA SADAARRSSD GEPRPLPRVA APGTTWRRIR DEDVPHILRS 2160
TLPATALPLR GSTPEDAPAG PPPRKTSDAV VQTEEVAAPK TNSSTSPSLE TREPPGAPAG 2220
GQLSLLGSDV DGPSLAKAPI SAPFVHEGLG VAVGGFPASR HGSPSRSARV PPFNYVPSPM 2280
WAATTDSAA EKAPATASAT LLE 2303
Seq ID NO 306 Protein Sequence
Protein Accession it NP_006356 1
1 11 21 31 41 51
I I I I I I
MFLTEDLITF NLRNFLLFQL WESSFSPGAG GFCTTLPPSF LRVDDRATSS TTDSSRAPSS 60 PRPPGSTSHC GISTRCTERC LCVLPLRTSQ VPDVMAPQHD QEKFHDLAYS CLGKSFSMSN 120 QDLYGYSTSS LALGLAWLSW ETKKKNVLHL VGLDSL 156
Seq ID NO 307 Protein Sequence Protein Accession U AAH32726 1 1 11 21 31 41 51
I I I I I I
MASTRSIELE HFEERDKRPR PGSRRGAPSS SGGSSSSGPK GNGLIPSPAH SAHCSFYRTR 60
TLQALSSEKK AKKARFYRNG DRYFKGLVFA ISSDRFRSFD ALLIELTRSL SDNVNLPQGV 120
RTIYTIDGSR KVTSLDELLE GESYVCASNE PFRKVDYTKN INPNWSVNIK GGTSRALAAA 180
SSVKSEVKES KDFIKPKLVT VIRSGVKPRK AVRILLNKKT AHSFEQVLTD ITEAIKLDSG 240
WKRLCTLDG KQVTCLQDFF GDDDVFIACG PEKFRYAQDD FVLDHSECRV LKSSYSRSSA 300
VKYSGSKSPG PSRRSKSPAS VNGTPSSQLS TPKSTKSSSS SPTSPGSFRG LKISAHGRSS 360
SNVNGGPELD RCISPEGVNG NRCSESSTLL EKYKIGKVIG DGNFAWKEC IDRSTGKEFA 420
LKIIDKAKCC GKEHLIENEV SILRRVKHPN IIMLVEEMET ATELFLVMEL VKGGDLFDAI 480
TSSTKYTERD GSAMVYNLAN ALRYLHGLSI VHRDIKPENL LVCEYPDCTK SLKLGDFGLA 540
TWEGPLYTV CGTPTYVAPE IIAETGYGLK VDIWAAGVIT YILLCGFPPF RSENNLQEDL 600
FDQILAGKLE FPAPYWDNIT DSAKELISQM LQVNVEARCT AGQILSHPWV SDDASQENNM 660
QAEVTGKLKQ HFNNALPKQN STTTGVSVIM FDLTV 695
Seq ID NO 308 Protein Sequence
Protein Accession If NP_055978 2
1 11 21 31 41 51
I I I I I I
MEEMEEELKC PVCGSFYREP IILPCSHNLC QACARNILVQ TPESESPQSH RAAGSGVSDY 60
DYLDLDKMSL YSEADSGYGS YGGFASAPTT PCQKSPNGVR VFPPAMPPPA THLSPALAPV 120
PRNSCITCPQ CHRSLILDDR GLRGFPKNRV LEGVIDRYQQ SKAAALKCQL CEKAPKEATV 180
MCEQCDVFYC DPCRLRCHPP RGPLAKHRLV PPAQGRVSRR LSPRKVSTCT DHELENHSMY 240
CVQCKMPVCY QCLEEGKHSS HEVKALGAMW KLHKSQLSQA LNGLSDRAKE AKEFLVQLRN 300
MVQQIQENSV EFEACLVAQC DALIDALNRR KAQLLARVNK EHEHKLKWR DQISHCTVKL 360
RQTTGLMEYC LEVIKENDPS GFLQISDALI RRVHLTEDQW GKGTLTPRMT TDFDLSLDNS 420
PLLQSIHQLD FVQVKASSPV PATPILQLEE CCTHNNSATL SWKQPPLSTV PADGYILELD 480
DGNGGQFREV YVGKETMCTV DGLHFNSTYN ARVKAFNKTG VSPYSKTLVL QTSEVAWFAF 540
DPGSAHSDII LSNDNLTVTC SSYDDR LG KTGFSKGIHY WELTVDRYDN HPDPAFGVAR 600
MDVMKDVMLG KDDKAWAMYV DNNRSWFMHN NSHTNRTEGG ITKGATIGVL LDLNRKNLTF 660
FINDEQQGPI AFDNVEGLFF PAVSLNRNVQ VTLHTGLPVP DFYSSRASIA 710
Seq ID NO 309 Protein Sequence
Protein Accession tt NP_116025 1
1 11 21 31 41 51
I I I I I I
MEDLEEDVRF IVDETLDFGG LSPSDSREEE DITVLVTPEK PLRRGLSHRS DPNAVAPAPQ 60
GVRLSLGPLS PEKLEEILDE ANRLAAQLEQ CALQDRESAG EGLGPRRVKP SPRRETFVLK 120
DSPVRDLLPT VNSLTRSTPS PSSLTPRLRS NDRKGSVRAL RATSGKRPSN MKRESPTCNL 180
FPASKSPASS PLTRSTPPVR GRAGPSGRAA ASPPTPIRSV LAPQPSTSNS QRLPRPQGAA 240
AKSSSQLPIP SAIPRPASRM PLTSRSVPPG RGALPPDSLS TRKGLPRPST AGHRVRESGH 300
KVPVSQRLNL PVMGATRSNL QPPRKVAVPG PTR 333
Seq ID NO 310 Protein Sequence
Protein Accession If ref |XP_166946 2
1 11 21 31 41 51
I I I I I I
MGSDSRLPEM EEKGSGDKAG WSGALLAEVK NQGLKLCEWM LVLKAELVEW YTSVIVGQQG 60 HRLKMDLLKE RHHRKYLQKP IKRCSGLMGL NWSLRPAISΞ SPLARSQEKH HGAKGNEGVK 120 ALSFRKLRKL KRPPTPPSQA KSWRGRTGSA ADSPGAAAMA VQAALLSTHP FVPFGFGGSP 180
DGLGGAFGAL DKGCCFEDDE TGAPAGALLS GAEGGDVREA TRDLLSFIDS ASSNIKLALD 240
KPGKSKRKVN HRNAPTVAAP AHGKAAPRRE ASQAAAAASL QSRSLAALFD SLRHVPGGAE 300
PAGGEVAAPA AGLGGAGTGG AGGDVAGPAG ATAIPGARKV PLRARNLPPS FFTEPSRAGG 360 GGCGPSGPDV SLGDLEKGAE AVEFFELLGP DYGAGTEAAV LLAAEPLDVF PAGASVLRGP 420
PELEPGLFEP PPA GNLLY PEPWSVPGCS PTKKSPLTAP RGGLTLNEPL SPLYPAAADS 480
PGGEDGRGHL ASFAPFFPDC ALPPPPPPHQ VSYDYSAGYS RTAYSSLWRS DGVWEGAPGE 540
EGAHRD 546 Seq ID NO 311 Protein Sequence Protein Accession ff NP_071406 1 1 11 21 31 41 51
M IAPTKPSFQQ DIPSRRERLQA LIRKEKSRDAA RISRRGKENFE FIYELAKLLPL PIAAITSQLDK 60 ASIIRLTISY LKMRDFANQG DPPWNLRMEG PPPNTSVKGA QRRRSPSALA IEVFEAHLGS 120
HILQSLDGFV FALNQEGKFL YISETVSIYL GLSQVELTGS SVFDYVHPGD HVEMAEQLGM 180
KLPPGRGLLS QGTAEDGASS ASSSSQSETP EPVESTSPSL LTTDNTLERS FFIRMKSTLT 240
KRGVHIKSSG YKVIHITGRL RLRVSLSHGR TVPSQIMGLV WAHALPPPT INEVRIDCHM 300
FVTRVNMDLN IIYCENRISD YMDLTPVDIV GKRCYHFIHA EDVEGIRHSH LDLLNKGQCV 360 TKYYRWMQKN GGYIWIQSSA TIAINAKNAN EKNIIWVNYL LSNPEYKDTP MDIAQLPHLP 420
EKTSESSETS DSESDSKDTS GITEDNENSK SDEKGNQSEN SEDPEPDRKK SGNACDNDMN 480
CNDDGHSSSN PDSRDSDDSF EHSDFENPKA GEDGFGALGA MQIKVERYVE SESDLRLQNC 540
ESLTSDSAKD SDSAGEAGAQ ASSKHQKRKK RRKRQKGGSA SRRRLSSASS PGGLDAGLVE 600
PPRLLSSPNS ASVLKIKTEI SEPINFDNDS SIWNYPPNRE ISRNESPYSM TKPPSSEHFP 660
SPQGGGGGGG GGGGLHVAIP DSVLTPPGAD GAAARKTQFG ASATAALAPV ASDPLSPPLS 720
ASPRDKHPGN GGGGGGGGGG AGGGGPSASN SLLYTGDLEA LQRLQAGNW LPLVHRVTGT 780
LAATSTAAQR VYTTGTIRYA PAEVTLAMQS NLLPNAHAVN FVDVNSPGFG LDPKTPMEML 840
YHHVHRLNMS GPFGGAVSAA SLTQMPAGNV FTTAEGLFST LPFPVYSNGI HAAQTLERKE 900
D 901
Seq ID NO 312 Protein Sequence
Protein Accession It NP_005797 1
1 11 21 31 41 51
M IDSDASLVSS RIPSSPEPDDL FILPARSKGSS GISAFTGGTVS SISTPSDCPPE LISAELRGAMG 60
SAGAHPGDKL GGSGFKSSSS STSΞSTSΞAA ASSTKKDKKQ MTEPELQQLR LKINSRERKR 120
MHDLNIAMDG LREVMPYAHG PSVRKLSKIA TLLLARNYIL MLTNSLEEMK RLVSEIYGGH 180
HAGFHPSACG GLAHSAPLPA ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS 240
ASLPGSGLPS VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG ASGGFQHWGG MPCPCSMCQV 300
PPPHHHVSAM GAGSLPRLTS DAK 323
Seq ID NO 313 Protein Sequence Protein Accession It XP_045127 3
1 11 21 31 41 51 I I I I I I
MTVLEESSIS LMSSWADFS EFEEDPQVFN TLFPSRPIVP LSSRSMEISE TSVGISAEVD 60
MSSVTTTQVP PAHGRLSVPA SLDPTAGSLS VAETQVTPSS VTTAFFSVIT SILLDSSFSV 120
IANKNTPSLA VRDPSVFTPY SLVPSVESSL FSDQERSSFS EHKPRGALDF ASSFFSTPPL 180
ELSGSISSPS EAPASLSLMP SDLSPFTSQS FSPLVETFTL FDSSDLQSSQ LSLPSSTNLE 240
FSQLQPSSEL PLNTIMLLPS RSEVSPWSSF PSDSLEPVEA STVSLTDSEA HFTSAFIETT 300
SYLESSLISH ESAVTALVPP GSESFDILTA GIQATSPLTT VHTTPILTES SLFSTLTPPD 360
DQISALDGHV SVLASFSKAI PTGTVLITDA YLPSGSSFVS EATPFPLPTE LTWGPSLTP 420
TEVPLNTSTE VSTTSTGAAT GGPLDSTLMG DAASQSPPES SAAPPLPSLR PVTAFTLEAT 480
VDTPTLATAK PPYVCDITVP DAYLITTVLA RRAVQEYIIT AIKEVLRIHF NRAVELKVYE 540
LFTDFTFLVT SGPFVYTAIS VINVLINSKL VRDQTPLILS VKPSFLVPES RFQVQTVLQF 600
VPPSVDTGFC NFTQRIEKGL MTALFEVRKH HQGTYNLTVQ ILNITISSSR VTPRRGPVNI 660
IFAVKSTQGF LNGSEVSELL RNLSWEFSF YLGYPVLQIA EPFQYPQLNL SQLLKSSWVR 720
TVLLGVMEKQ LQNEVFQAEM ERKLAQLLSE VSTRRRMWRR ATVAAGNSW QWNVSRLEG 780
DDNPVQLIYF VEDQDGERLS AVKSSDLINK MDLQRAAIIL GYRIQGVIAQ PVDRVKRPΞP 840
ESQSNNLWVI VGWIPVLW MVIWILYWK LCRTDKLDFQ PDTVANIQQR QKLQIPSVKG 900
FDFAKQHLGQ HNKDDILIIH EPAPLPGPLK DHTTPSENGD VPSPKSKIPS KNVRHRGRVS 960
PSDADSTVSE ESSERDAGDK TPGAVNDGRS HRAPQSGPPL PSSGNEQHSS ASIFEHVDRI 1020
SRPPEASRRV PSKIQLIAMQ PIPAPPVQRP SPADRVAESN KINKEIQTAL RHKSEIEHHR 1080
NKIRLRAKRR GHYEFP DD LSSGDTKERH RVYRRAQMQI DKILDPTASV PSVFIEPRKS 1140
SRIKRSPKPR RKHQVNGCPA DAEKDRLITT DSDGTYRRPP GVHNSAYIGC PSDPDLPADV 1200
QTPSSVELGR YPALPFPASQ YIPPQPSIEE ARQTMHSLLD DAFALVAPSS QPASTAGVGP 1260
GVPPGLPANS TPSQEERRAT QWGSFYSPAQ TANNPCSRYE DYGMTPPTGP LPRPGFGPGL 1320
LQSTELVPPD PQQPQASAEA PFAARGIYSE EMPSVARPRP VGGTTGSQIQ HLTQVGIASR 1380
IGAQPVEIPP SRGSQYGGPG WPSYGEDEAG RREAVPRTSG REPSAPSGNL PHRGLQGPGL 1440
GYPTSSTEDL QPGHSSASLI KAIREELLRL SQKQSTVQNF HS 1482
Seq ID NO 314 Protein Sequence Protein Accession # BAC04820 1 1 11 21 31 41 51 I I I I I I
MAPRPLGPLV LALGGAAAVL GSVLPILWKT YFGRGRERRW DRGEAWWGAE AARLPEWDEW 60
DPEDEEDEEP ALEELEQREV LVLGLDGAGK STFLRVLSGK PPLEGHIPTW GFNSVRLPTK 120 DFEVDLLEIG GSQNLRFYWK EFVSEVDVLV FWDSADRLR LPWARQELHK LLDKDPDLPV 180
VWANKQDLS EAMSMGELQR ELGLQAIDNQ REVFLLAASI APAGPTFEEP GTVHIWKLLL 240 ELLS 244
Seq ID NO 315 Protein Sequence
Protein Accession tl NP_066S63 1
1 11 21 31 41 51 I I I I I I
MARRAGGARM FGSLLLFALL AAGVAPLSWD LPEPRSRASK IRVHSRGNLW ATGHFMGKKS 60
LEPSSPSHWG QLPTPPLRDQ RLQLSHDLLG ILLLKKALGV SLSRPAPQIQ YRRLLVQILQ 120
K 121
Seq ID NO- 316 Protein Sequence
Protein Accession I) NP_002046.1
1 11 21 31 41 51 ιn I I I I I I
1U MERRRITSAA RRSYVSSGEM MVGGLAPGRR LGPGTRLSLA RMPPPLPTRV DFSLAGALNA 60
GFKETRASER AEMMELNDRF ASYIEKVRFL EQQNKALAAE LNQLRAKEPT KLADVYQAEL 120
RELRLRLDQL TANSARLEVE RDNLAQDLAT VRQKLQDETN LRLEAENNLA AYRQEADEAT 180
LARLDLERKI ESLEEEIRFL RKIHEEEVRE LQEQLARQQV HVELDVAKPD LTAALKEIRT 240
QYEAMASSNM HEAEEWYRSK FADLTDAAAR NAELLRQAKH EANDYRRQLQ SLTCDLESLR 300
15 GTNESLERQM REQEERHVRE AASYQEALAR LEEEGQSLKD EMARHLQEYQ DLLNVKLALD 360
IEIATYRKLL EGEENRITIP VQTFSNLQIR ETSLDTKSVS EGHLKRNI KTVEMRDGEV 420
IKESKQEHKD VM 432
Seq ID NO: 317 Protein Sequence
20 Protein Accession ft: AAA19191.1 1 11 21 31 41 51
I I I I I I
MRLLSSLSGS SVSSDAEEYQ PPIWKSYLYQ LQQEAPRPKR IICPREVENR PKYYGREFHG 60
IISREQADEL LGGVEGAYIL RESQRQPGCY TLALRFGNQT LNYRLFHDGK HFVGEKRFES 120
25 IHDLVTDGLI TLYIETKAAE YISKMTTNPI YEHIGYATLL REKVSRRLSR SKNEPRKTNV 180
THEEHTAVEK ISSLVRRAAL THNDNHFNYE KTHNFKVHTF RGPHWCEYCA NFMWGLIAQG 240
VRCSDCGLNV HKQCSKHVPN DCQPDLKRIK KVYCCDLTTL VKAHNTQRPM WDICIREIE 300
ARGLKSEGLY RVSGFTEHIE DVKMAFDRDG EKADISANVY PDINIITGAL KLYFRDLPIP 360
VITYDTYSKF IDAAKISNAD ERLEAVHEVL MLLPPAHYET LRYLMIHLKK VTMNEKDNFM 420
30 NAENLGIVFG PTLMRPPEDS TLTTLHDMRY QKLIVQILIE NEDVLF 466
Seq ID NO: 318 Protein Sequence
Protein Accession ft: XP_1135S3.1
1 11 21 31 41 51
35 I I I I I I
MKRAHPEYSS SDSELDETIE VEKESADENG NLSSALGSMS PTTSSQILAR KRRRGIIEKR 60
RRDRINNSLS ELRRLVPSAF EKQGSAKLEK AEILQMTVDH LKMLHTAGGK GYFDAHALAM 120
DYRSLGFREC LAEVARYLSI IEGLDASDPL RVRLVSHLNN YASQREAASG AHAGLGHIPW 180
GTVFGHHPHI AHPLLLPQNG HGNAGTTASP TEPHHQGRLG SAHPEAPALR APPSGSLGPV 240
40 LPWTSASKL SPPLLSSVAS LSAFPFSFGS FHLLSPNALS PSAPTQAANL GKPYRPWGTE 300
IGAF 304
Seq ID NO: 319 Protein Sequence
Protein Accession ft: NP_001927.2
45 1 11 21 31 41 51
I I I I I I
MTTAKEPSAS GKSVQQQEQE LVGSNPPQRN WKGIAIALLV ILVICSLIVT SVILLTPAED 60
NSLSQKKKVT VEDLFSEDFK IHDPEAKWIS DTEFIYREQK GTVRLWNVET NTSTVLIEGK 120
KIESLRAIRY EISPDREYAL FSYNVEPIYQ HSYTGYYVLS KIPHGDPQSL DPPEVSNAKL 180
50 QYAGWGPKGQ QLIFIFENNI YYCAHVGKQA IRWSTGKEG VIYNGLSDWL YEEEILKTHI 240
AHWWSPDGTR LAYAAINDSR VPIMELPTYT GSIYPTVKPY HYPKAGSENP SISLHVIGLN 300
GPTHDLEMMP PDDPRMREYY ITMVKWATST KVAVTWLNRA QNVSILTLCD ATTGVCTKKH 360
EDESEAWLHR QNEEPVFSKD GRKFFFIRAI PQGGRGKFYH ITVSSSQPNS SNDNIQSITS 420
GDWDVTKILA YDEKGNKIYF LSTEDLPRRR QLYSANTVGN FNRQCLSCDL VENCTYFSAS 480
55 FSHSMDFFLL KCEGPGVPMV TVHNTTDKKK MFDLETNEHV KKAINDRQMP KVEYRDIEID 540
DYNLPMQILK PATFTDTTHY PLLLWDGTP GSQSVAEKFE VSWETVMVSS HGAVWKCDG 600
RGSGFQGTKL LHEVRRRLGL LEEKDQMEAV RTMLKEQYID RTRVAVFGKD YGGYLSTYIL 660
PAKGENQGQT FTCGSALSPI TDFKLYASAF SERYLGLHGL DNRAYEMTKV AHRVSALEEQ 720
QFLIIHPTAD EKIHFQHTAE LITQLIRGKA NYΞLQIYPDE SHYFTSSSLK QHLYRSIINF 780
60 FVECFRIQDK LPTVTAKEDE EED 803
Seq ID NO: 320 Protein Sequence Protein Accession #: XP_087461.1 , . 1 11 21 31 41 51
65 i i i i i i
MLPLLAALLA AACPLPPVRG GAADAPGLLG VPSNASVNAS SAASPSPRGC WPRRPPGPPS 60
ARARRRRRRR RRLCNISVQR QMLSSLLVRW GRPRGFQCDL LLFSTNAHGR AFFAAAFHRV 120
GPPLLIEHLG LAAGGAQQDL RLCVGCGWVR GRRTGRLRPA AAPSAAAATA GAPTALPAYP 180
AAEPPGPLWL QGEPLHFCCL DFSLEELQGE PGWRLNRKPI ESTLVACFMT LVIWWSVAA 240
70 LIWPVPIIAG FLPNGMEQRR TTASTTAATP AAVPAGTTAA AAAAAAAAAA AVTSGVATK 299
Seq ID NO: 321 Protein Sequence Protein Accession it . NP_036393.1 __ 1 11 21 31 41 51
75 i i i i i i
MDLQGRGVPS IDRLRVLLML FHTMAQIMAE QEVENLSGLS TNPEKDIFW RENGTTCLMA 60
EFAAKFIVPY DVWASNYVDL ITEQADIALT RGAEVKGRCG HSQSELQVFW VDRAYALKML 120
FVKESHNMSK GPEATWRLSK VQFVYDSSEK THFKDAVSAG KHTANSHHLS ALVTPAGKSY 180
ECQAQQTISL ASSDPQKTVT MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI 240
80 LGLILGLVIM VTLAIYHVHH KMTANQVQIP RDRSQYKHMG 280
Seq ID NO: 322 Protein Sequence
Protein Accession It: NP_653187
1 11 21 31 41 51 I I I I I I
MWVLGIAATF CGLFLLPGFA LQIQCYQCEE FQLNNDCSSP EFIVNCTVNV QDMCQKEVME 60
QSAGIMYRKS CASSAACLIA SAGYQSFCSP GKLNSVCISC CNTPLCNGPR PKKRGSSASA 120
LRPGLRTTIL FLKLALFSAH C 141
Seq ID NO 323 Protein Sequence
Protein Accession It NP_004685
1 11 21 31 41 51 i 1nU M TQNKLKLCS K 'ANVYTEVPD G 'GWGWAVAVS F 'FFVEVFTYG I 'IKTFGVFFN D 'LMDSFNESN 60
SRISWIISIC VFVLTFSAPL ATVLSNRFGH RLWMLGGLL VSTGMVAASF SQEVSHMYVA 120
IGIISGLGYC FSFLPTVTIL SQYFGKRRSI VTAVASTGEC FAVFAFAPAI MALKERIGWR 180
YSLLFVGLLQ LNIVIFGALL RPIIIRGPAS PKIVIQENRK EAQYMLENEK TRTSIDSIDS 240
GVELTTSPKN VPTHTNLELE PKADMQQVLV KTSPRPSEKK APLLDFSILK EKSFICYALF 300
15 GLFATLGFFA PSLYIIPLGI SLGIDQDRAA FLLSTMAIAE VFGRIGAGFV LNREPIRKIY 360
1ELICVILLT VSLFAFTFAT EFWGLMSCSI FFGFMVGTIG GLTFHCLLKM MSWALQKMSS 420
AAGVYIFIQS IAGLAGPPLA GLLVDQSKIY SRAFYSCAAG MALAAVCLAL VRPCKMGLCQ 480
RHHSGETKW SHRGKTLQDI PEDFLEMDLA KNEHRVHVQM EPV 523
20 Seq ID NO 324 Protein Sequence Protein Accession tt NP_004824 1 1 11 21 31 41 51
I I I I I I
MESKYKEILL LTGLDNITDE ELDRFKFFLS DEFNIATGKL HTANRIQVAT LMIQNAGAVS 60
25 AVMKTIRIFQ KLNYMLLAKR LQEEKEKVDK QYKSVTKPKP LSQAEMSPAA SAAIRNDVAK 120
QRAAPKVSPH VKPEQKQMVA QQESIREGFQ KRCLPVMVLK AKKPFTFETQ EGKQEMFHAT 180
VATEKEFFFV KVFNTLLKDK FIPKRIIIIA RYYRHSGFLE VNSASRVLDA ESDQKVNVPL 240
NIIRKAGETP KINTLQTQPL GTIVNGLFW QKVTEKKKNI LFDLSDNTGK MEVLGVRNED 300
TMKCKEGDKV RLTFFTLSKN GEKLQLTSGV HSTIKVIKAK KKT 343
30
Seq ID NO 325 Protein Sequence
Protein Accession tt NP_005400 1
1 11 21 31 41 51
I I I I I I
35 MSVKGMAIAL AVILCATWQ GFPMFKRGRC LCIGPGVKAV KVADIEKASI MYPSNNCDKI 60
EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF 94
Seq ID NO 326 Protein Sequence
Protein Accession II NP_002553 1
40 1 11 21 31 41 51
I I I I I I
MPACCSCSDV FQYETNKVTR IQSMNYGTIK WFFHVIIFSY VCFALVSDKL YQRKEPVISS 60
VHTKVKGIAE VKEEIVENGV KKLVHSVFDT ADYTFPLQGN SFFVMTNFLK TEGQEQRLCP 120
EYPTRRTLCS SDRGCKKGWM DPQSKGIQTG RCWHEGNQK TCEVSAWCPI EAVEEAPRPA 180
45 LLNSAENFTV LIKNNIDFPG HNYTTRNILP GLNITCTFHK TQNPQCPIFR LGDIFRETGD 240
NFSDVAIQGG IMGIEIYWDC NLDRWFHHCH PKYSFRRLDD KTTNVSLYPG YNFRYAKYYK 300
ENNVEKRTLI KVFGIRFDIL VFGTGGKFDI IQLWYIGST LSYFGLAAVF IDFLIDTYSS 360
NCCRSHIYPW CKCCQPCWN EYYYRKKCES IVEPKPTLKY VSFVDESHIR MVNQQLLGRS 420
LQDVKGQEVP RPAMDFTDLS RLPLALHDTP PIPGQPEEIQ LLRKEATPRS RDSPVWCQCG 480
50 SCLPSQLPES HRCLEELCCR KKPGACITTS ELFRKLVLSR HVLQFLLLYQ EPLLALDVDS 540
TNSRLRHCAY RCYATWRFGS QDMADFAILP SCCRWRIRKE FPKSEGQYSG FKSPY 595
Seq ID NO 327 Protein Sequence
Protein Accession If NP_001784 2
55 1 11 21 31 41 51
I I I I I I
MGLPRGPLAS LLLLQVCWLQ CAASEPCRAV FREAEVTLEA GGAEQEPGQA LGKVFMGCPG 60
QEPALFSTDN DDFTVRNGET VQERRSLKER NPLKIFPSKR ILRRHKRDWV VAPISVPENG 120
KGPFPQRLNQ LKSNKDRDTK IFYSITGPGA DSPPEGVFAV EKETGWLLLN KPLDREEIAK 180
60 YELFGHAVSE NGASVEDPMN ISIIVTDQND HKPKFTQDTF RGSVLEGVLP GTSVMQVTAT 240
DEDDAIYTYN GWAYSIHSQ EPKDPHDLMF TIHRSTGTIS VIΞSGLDREK VPEYTLTIQA 300
TDMDGDGSTT TAVAWEILD ANDNAPMFDP QKYEAHVPEN AVGHEVQRLT VTDLDAPNSP 360
AWRATYLIMG GDDGDHFTIT THPESNQGIL TTRKGLDFEA KNQHTLYVEV TNEAPFVLKL 420
PTSTATIWH VEDVNEAPVF VPPSKWEVQ EGIPTGEPVC VYTAEDPDKE NQKISYRILR 480
65 DPAGWLAMDP DSGQVTAVGT LDREDEQFVR NNIYEVMVLA MDNGSPPTTG TGTLLLTLID 540
VNDHGPVPEP RQITICNQSP VRQVLNITDK DLSPHTSPFQ AQLTDDSDIY WTAEVNEEGD 600
TWLSLKKFL KQDTYDVHLS LSDHGNKEQL TVIRATVCDC HGHVETCPGP WKGGFILPVL 660
GAVLALLFLL LVLLLLVRKK RKIKEPLLLP EDDTRDNVFY YGEEGGGEED QDYDITQLHR 720
GLEARPEWL RNDVAPTIIP TPMYRPRPAN PDEIGNFIIE NLKAANTDPT APPYDTLLVF 780
70 DYEGSGSDAA SLSSLTSSAS DQDQDYDYLN EWGSRFKKLA DMYGGGEDD 829
Seq ID NO 328 Protein Sequence
Protein Accession tt NP_002562 1
1 11 21 31 41 51
75 I I I I I I
MDIPQTKQDL ELPKLAGTWH SMAMATNNIS LMATLKAPLR VHITSLLPTP EDNLEIVLHR 60 WENNSCVEKK VLGEKTGNPK KFKINYTVAN EATLLDTDYD NFLFLCLQDT TTPIQSMMCQ 120 YLARVLVEDD EIMQGFIRAF RPLPRHLWYL LDLKQMEEPC RF 162
80 Seq ID NO 329 Protein Sequence LEK6
Protein Accession NP_001318 1
1 11 21 31 41 51
I I I I I I
MQAEGRGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPGGGA 60 PRGPHGGAAS GLNGCCRCGA RGPESRLLEF YLAMPFATPM EAELARRSLA QDAPPLPVPG 120 VLLKEFTVSG NILTIRLTAA DHRQLQLSIS SCLQQLSLLM WITQCFLPVF LAQPPSGQRR 180
Seq ID NO 330 Protein Sequence LEK6
Protein Accession tt NP_066274
1 11 21 31 41 51
I I I I I I
MQAEGQGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPRGGA 60 PRGPHGGAAS AQDGRCPCGA RRPDSRLLQF RLTAADHRQL QLSISSCLQQ LSLLMWITQC 120 FLPVFLAQAP SGQRR 135
Seq ID NO 331 Protein Sequence
Protein Accession it NP_008859 1
1 11 21 31 41 51 i i i i i i
MDLVLKRCLL HLAVIGALLA VGATKVPRNQ DWLGVSRQLR TKAWNRQLYP EWTEAQRLDC 60
WRGGQVSLKV SNDGPTLIGA NASFSIALNF PGSQKVLPDG QVIWVNNTII NGSQVWGGQP 120
VYPQETDDAC IFPDGGPCPS GSWSQKRSFV YVWKTWGQYW QVLGGPVSGL SIGTGRAMLG 180
THTMEVTVYH RRGSRSYVPL AHSSSAFTIT DQVPFSVSVS QLRALDGGNK HFLRNQPLTF 240 ALQLHDPSGY LAEADLSYTW DFGDSSGTLI SRAL THTY LEPGPVTAQV VLQAAIPLTS 300
CGSSPVPGTT DGHRPTAEAP NTTAGQVPTT E GTTPGQA PTAEPSGTTS VQVPTTEVIS 360
TAPVQMPTAE STGMTPEKVP VSEVMGTTLA EMSTPEATGM TPAEVSI L SGTTAAQVTT 420
TEWVETTARE LPIPEPEGPD ASSIMSTESI TGSLGPLLDG TATLRLVKRQ VPLDCVLYRY 480
GSFSVTLDIV QGIESAEILQ AVPSGEGDAF ELTVSCQGGL PKEACMEISS PGCQPPAQRL 540
CQPVLPSPAC QLVLHQILKG GSGTYCLNVS LADTNSLA STQLIMPGQE AGLGQVPLIV 600
GILLVLMAW LASLIYRRRL MKQDFSVPQL PHSSSHWLRL PRIFCSCPIG ENSPLLSGQQ 660
V 661
Seq ID NO 332 Protein Sequence Protein Accession It NP_001913 2
1 11 21 31 41 51
I I I I I I
MSPLWWGFLL SCLGCKILPG AQGQFPRVCM TVDSLVNKEC CPRLGAESAN VCGSQQGRGQ 60
CTEVRADTRP WSGPYILRNQ DDRELWPRKF FHRTCKCTGN FAGYNCGDCK FGWTGPNCER 120 KKPPVIRQNI HSLSPQEREQ FLGALDLAKK RVHPDYVITT QHWLGLLGPN GTQPQFANCS 180
VYDFFVWLHY YSVRDTLLGP GRPYRAIDFS HQGPAFVTWH RYHLLCLERD LQRLIGNESF 240
ALPYWNFATG RNECDVCTDQ LFGAARPDDP TLISRNSRFS SWETVCDSLD DYNHLVTLCN 300
GTYEGLLRRN QMGRNSMKLP TLKDIRDCLS LQKFDNPPFF QNSTFSFRNA LEGFDKADGT 360
LDSQVMSLHN LVHSFLNGTN ALPHSAANDP IFWLHSFTD AIFDEWMKRF NPPADAWPQE 420 LAPIGHNRMY NMVPFFPPVT NEELFLTSDQ LGYSYAIDLP VΞVEETPGWP TTLLWMGTL 480
VALVGLFVLL AFLQYRRLRK GYTPLMETHL SSKRYTEEA 519
Seq ID NO 333 Protein Sequence
Protein Accession It XP_059422 1
1 11 21 31 41 51
I I I I I I
MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN IVISPHGIAS 60
VLGMLQLGAD GRTKKQLAMV MRYGVNGVGK ILKKINKAIV SKKNKDIVTV ANAVFVKNAS 120
EIEVPFVTRN KDVFQCEVRN VNFEDPASAC DSINAWVKNE TRDMIDNLLS PDLIDGVLTR 180
LVLVNAVYFK GLWKSRFQPE NTKKRTFVAA DGKSYQVPML AQLSVFRCGS TSAPNDLWYN 240
FIELPYHGES ISMLIALPTE SSTPLSAIIP HISTKTIDSW MSIMVPKRVQ VILPKFTAVA 300
QTDLKEPLKV LGITDMFDSS KANFAKITRS ENLHVSHILQ KAKIEVSEDG TKASAATTAI 360
LIARSSPPWF IVDRPFLFFI RHNPTGAVLF MGQINKP 397
Seq ID NO 334 Protein Sequence
Protein Accession If XP_040512 2
1 11 21 31 41 51
I I I I I I
MRQHDTRNGR IVLISGRRSF CSIFSVLPYR DSTQVGDLKL DGGRQSTGAV SLKEIIGLEG 60
VELGADGKTV SYTQFLLPTN AFGARRNTID STSSFSQFRN LSHRSLSIGR ASGTQGSLDT 120
GSDLGDFMDY DPNLLDDPQW PCGKHKRVLI FPSYMTTVID YVKPSDLKKD MNETFKEKFP 180
HIKLTLSKIR SLKREMRKLA QEDCGLEEPT VAMAFVYFEK LALKGKLNKQ NRKLCAGACV 240
LLAAKIGSDL KKHEVKHLID KLEEKFRLNR RELIAFEFPV LVALEFALHL PEHEVMPHYR 300
RLVQSS 306
Seq ID NO 335 Protein Sequence
Protein Accession ft AAH08826
1 11 21 31 41 SI
I I I I I I
MTTLAGAVPR MMRPGPGQNY PRSGFPLEVS TPLGQGRVNQ LGGVFINGRP LPNHIRHKIV 60
EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA IGGSKPKVTT PDVEKKIEEY 120
KRENPGMFSW EIRDKLLKDA VCDRNTVPSV SSISRILRSK FGKGEEEEAD LERKEAEESE 180
KKAKHSIDGI LSERASAPQS DEGSDIDSEP DLPLKRKQRR SRTTFTAEQL EELERAFERT 240
HYPDIYTREE LAQRAKLTEA RVQVWFSNRR ARWRKQAGAN QLMAFNHLIP GGFPPTAMPT 300
LPTYQLSETS YQPTSIPQAV SDPSSTVHRP QPLPPSTVHQ STIPSNPDSS SAYCLPSTRH 360
GFSSYTDΞFV PPSGPSNPMN PTIGNGLSPQ NSIRHNLSLH SKFIRVQNEG TGKSSWWMLN 420
PEGGKSGKSP RRRAASMDNN SKFAKSRSRA AKKKASLQSG QEGAGDSPGS QFSKWPASPG 480
SHSNDDFDNW STFRPRTSSN ASTISGRLSP IMTEQDDLGE GDVHSMVYPP SAAKMASTLP 540
SLSEISNPEN MENLLDNLNL LSSPTSLTVS TQSSPGTMMQ QTPCYSFAPP NTSLNSPSPN 600
YQKYTYGQSS MSPLPQMPIQ TLQDNKSSYG GMSQYNCAPG LLKELLTSDS PPHNDIMTPV 660
DPGVAQPNSR VLGQNVMMGP NSVMSTYGSQ ASHNKMMNPS SHTHPGHAQQ TSAVNGRPLP 720
HTVSTMPHTS GMNRLTQVKT PVQVPLPHPM QMSALGGYSS VSSCNGYGRM GLLHQEKLPS 780
DLDGMFIERL DCDMESIIRN DLMDGDTLDF NFDNVLPNQS FPHSVKTTTH SWVSG 835 Seq ID NO- 336 Protein Sequence
Protein Accession II NP_005752 1
1 11 21 31 41 51
I I I I I I
MEVSRRKAPP RPPRPAAPLP LLAYLLALAA PGRGADEPVW RSEQAIGAIA ASQEDGVFVA 60
SGSCLDQLDY SLEHSLSRLY RDQAGNCTEP VSLAPPARPR PGSSFSKLLL PYREGAAGLG 120
GLLLTGWTFD RGACEVRPLG NLSRNSLRNG TEWSCHPQG STAGWYRAG RNNRWYLAVA 180
ATYVLPEPET ASRCNPAASD HDTAIALKDT EGRSLATQEL GRLKLCEGAG SLHFVDAFLW 240
NGSIYFPYYP YNYTSGAATG WPSMARIAQS TEVLFQGQAS LDCGHGHPDG RRLLLSSSLV 300
EALDVWAGVF SAAAGEGQER RSPTTTALCL FRMSEIQARA KRVSWDFKTA ESHCKEGDQP 360
ERVQPIASST LIHSDLTSVY GTWMNRTVL FLGTGDGQLL KVILGENLTS NCPEVIYEIK 420
EETPVFYKLV PDPVKNIYIY LTAGKEVRRI RVANCNKHKS CSECLTATDP HCGWCHSLQR 480
CTFQGDCVHS ENLENWLDIS SGAKKCPKIQ IIRSSKEKTT VTMVGSFSPR HSKCMVKNVD 540
SSRELCQNKS QPNRTCTCSI PTRATYKDVS NVMFSFGS WNLSDRFNFT NCSSLKECPA 600 CVETGCAWCK SARRCIHPFT ACDPSDYERN QEQCPVAVEK TSGGGRPKEN KGNRTNQALQ 660
VFYIKSIEPQ KVSTLGKSNV IVTGANFTRA SNITMILKGT STCDKDVIQV SHVLNDTHMK 720
FSLPSSRKEM KDVCIQFDGG NCSSVGSLSY IALPHCSLIF PATTWISGGQ NITMMGRNFD 780
VIDNLIISHE LKGNINVSEY CVATYCGFLA PSLKSSKVRT NVTVKLRVQD TYLDCGTLQY 840
REDPRFTGYR VESEVDTELE VKIQKENDNF NISKKDIEIT LFHGENGQLN CSFENITRNQ 900
DLTTILCKIK GIKTASTIAN SSKKVRVKLG NLELYVEQES VPSTWYFLIV LPVLLVIVIF 960
AAVGVTRHKS KELSRKQSQQ LELLESELRK EIRDGFAELQ MDKLDWDSF GTVPFLDYKH 1020
FALRTFFPES GGFTHIFTED MHNRDANDKN ESLTALDALI CNKSFLVTVI HTLEKQKNFS 1080
VKDRCLFASF LTIALQTKLV YLTSILEVLT RDLMEQCSNM QPKLMLRRTE SWEKLLTNW 1140
MSVCLSGFLR ETVGEPFYLL VTTLNQKINK GPVDVITCKA LYTLNEDWLL WQVPEFSTVA 1200
LNWFEKIPE NESADVCRNI SVNVLDCDTI GQAKEKIFQA FLSKNGSPYG LQLNEIGLEL 1260
QMGTRQKELL DIDSSSVILE DGITKLNTIG HYEISNGSTI KVFKKIANFT SDVEYSDDHC 1320
HLILPDSEAF QDVQGKRHRG KHKFKVKEMY LTKLLSTKVA IHSVLEKLFR SIWSLPNSRA 1380
PFAIKYFFDF LDAQAENKKI TDPDWHIWK TNSLPLRFWV NILKNPQFVF DIKKTPHIDG 1440
CLSVIAQAFM DAFSLTEQQL GKEAPTNKLL YAKDIPTYKE EVKSYYKAIR DLPPLSSSEM 1500
EEFLTQESKK HENEFNEEVA LTEIYKYIVK YFDEILNKLE RERGLEEAQK QLLHVKVLFD 1560
EKKKCKWM 1568
Seq ID NO: 337 Protein Sequence
Protein Accession II: XP_063670.1
1 11 21 31 41 51
I I I I I I
MQRILEEPAD DCTWSTRILL TLSEFIMSLQ RTVYPHSEKW RALSVPSSSY FQELVGTSQE 60
LALTFWHLLS MFGFFIVSYG FLTAFGRTLF HLDLLQPNLT PSRFDKYTGL FIYEIEGDGL 120
DPCFQSMVQG ILEVLWMSKV ESAYHT DGD TAGEGVENGT SQTRGGGGAA RSRCREMEEP 180
TPEPVYVDVD KGLTLACFVF LCLFLWMII RCAKVIMDPY SAIPTSTWEE QHLDD 235
Seq ID NO: 338 Protein Sequence
Protein Accession If : FGENESH predicted
1 11 21 31 41 51 i i i i i i
MEPSHSQPTM DMKHMQERPA ASPLKCQDGR GSAQSPLSAA GPGSPAPLGA LTPAEPGLGS 60
APRAPRARAP VTGKRRSRRS AVALGSAPAQ PGPRERTGRA SPALENNSDL LSKASAIATG 120
TPPCEDSTIA RFYLPPPLTT HPELVGTSQE LALTFWHLLS MFGFFIVSYG FLTAFGRTLF 180
HLDLLQPNLT PSRFDKYTGQ LLELPVHSKY VLTIHWSQGL CIWSSHPCEA GVENGTSQTR 240
GGGGAARSRC REMEEPTPEP VYVDVDKGLT LACFVFLCLF LWMIIRCAK VIMDPYSAIP 300
TSTWEEQHLD D 311
Seq ID NO. 339 Protein Sequence
Protein Accession ft: FGENESH predicted
1 11 21 31 41 51
I I I I I I
MGKDFMSKTP KAMATQAKID KWDLIKLKSF CTAKETTIRV NRQPTEWEKI FAIYSSDEGL 60
ISRIYNEPKQ IYKKKTNNPI NKWAKDMNRH FSKEDIYAAN RHMKKCSSSL AIREMQIKTT 120
TRCHLTPVRM AIIKKSGNNR TAEEQPKLRK EAVGSIEIFR FADGLDITLM ILGILASLVN 180
GACLPLMPLV LGEMSDNLIS GCLVQTNTTN YQNCTQSQEK LNEDMTLLTL YYVGIGVAAL 240
IFGYIQISLW IITAARQTKR IRKQFFHSVL AQDIGWFDSC DIGELNTRMT DDIDKISDGI 300
GDKIALLFQN MSTFSIGLAV GLVKGWKLTL VTLSTSPLIM ASAAACSRMV ISLTSKELSA 360
YSKAGAVAEE VLSSIRTVIA FRAQEKELQR YTQNLKDAKD FGIKRTIASK VSLGAVYFFM 420
NGTYGLAFWY GTSLILNGEP GYTIGTVLAV FFSVIHSSYC IGAAVPHFET FAIARGAAFH 480
IFQVIDKKPS IDNFSTAGYK PESIEGTVEF KNVSFNYPSR PSIKILKGLN LRIKSGETVA 540
LVGLNGSGKS TWQLLQRLY DPDDGFIMVD ENDIRALNVR HYRDHIGWS QEPVLFGTTI 600
SNNIKYGRDD VTDEEMERAA REANAYDFIM EFPNKPNTLV GEKGAQMSGG QKQRIAIARA 660
LVRNPKILIL DEATSALDSE SKSAVQAALE KDTPRYSF 698
Seq ID NO: 340 Protein Sequence
Protein Accession If: XP_166496.1
1 11 21 31 41 51
I I I I I I
MVDENDIRAL NVRHYRDHIG SQEPVLFG TTISNNIKYG RDDVTDEEME RAAREANAYD 60 FIMEFPNKFN TLVGEKGAQM SGGQKQRIAI ARALVRNPKI LILDEATSAL DSESKSAVQA 120 ALEKDTPRYS F 131
Seq ID NO: 341 Protein Sequence
Protein Accession It: XP_166305.1
1 11 21 31 41 51
I I I I I I
MEKFRAVLDL HVKHHSALGY GLVTLLTAGG ERIFSAVAFQ CPCSAAWNLP YGLVFLLVPA 60 LALFLLGYVL SARTWRLLTG CCSSARASCG SALRGSLVCT QISAAAALAP LTWVAVALLG 120 GAFYECAATG SAAFAQRLCL GRNRSCAAEL PLVPCNQAKA SDVQDLLKDL KAQSQVLGWI 180 LIAWIIILL IFTSVTRCLS PVSFLQLKFW KIYLEQEQQI LKSKATEHAT ELAKENIKCF 240
FEGSHPKEYN TPSMKEWQQI SSLYTFNPKG QYYSMLHKYV NRKEKTHSIR STEGDTVIPV 300
LGFVDSSGIN STPEL 315 Seq ID NO 342 Protein Sequence Protein Accession ^ NP_115587 S 1 11 21 31 41 51
I I I I I I
MARSPPATLF LFLLLLGQPP PSRPQSLGTT KLRLVGPESK PEEGRLEVLH QGQWGTVCDD 60 NFAIQEATVA CRQLGFEAAL TWAHSAKYGQ GEGPIWLDNV QCVGTESSLD QCGSNGWGVS 120
DCSHSEDVGV ICHPRRHRGY LSETVSNALG PQGRRLEEVR LKPILASAKQ HSPVTEGAVE 180
VKYEGHWRQV CDQGWTMNNS RWCGMLGFP SEVPVDSHYY RKVWDLKMRD PKSRLKSLTN 240
KNSFWIHQVT CLGTEPHMAN CQVQVAPARG KLRPACPGGM HAWSCVAGP HFRPPKTKPQ 300
RKGSWAEEPR VRLRSGAQVG EGRVEVLMNR QWGTVCDHRW NLISASWCR QLGFGSAREA 360 LFGARLGQGL GPIHLSEVRC RGYERTLSDC PALEGSQNGC QHENAAAVRC NVPNMGFQNQ 420
VRLAGGRIPE EGLLEVQVEV NGVPRWGSVC SENWGLTEAM VACRQLGLGF AIHAYKETWF 480
WSGTPRAQEV VMSGVRCSGT ELALQQCQRH GPVHCSHGGG RFLAGVSCMD SAPDLVMNAQ 540
LVQETAYLED RPLSQLYCAH EENCLSKSAD HMDWPYGYRR LLRFSTQIYN LGRTDFRPKT 600
GRDSWVWHQC HRHYHSIEVF THYDLLTLNG SKVAEGHKAS FCLEDTNCPT GLQRRYACAN 660 FGEQGVTVGC WDTYRHDIDC QWVDITDVGP GNYIFQVIVN PHYEVAESDF SNNMLQCRCK 720
YDGHRVWLHN CHTGNSYPAN AELΞLEQEQR LRNNLI 756
Seq ID NO 343 Protein Sequence
Protein Accession ft NP_001789 2
1 11 21 31 41 51
I I I I I I
MENFQKVEKI GEGTYGWYK ARNKLTGEW ALKKIRLDTE TEGVPSTAIR EISLLKELNH 60
PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS 120
HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEWTLWYRA PEILLGCKYY 180
STAVDIWΞLG CIFAEMVTRR ALFPGDSEID QLFRIFRTG TPDEWWPGV TSMPDYKPSF 240
PKWARQDFSK WPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL 298
Seq ID NO 344 Protein Sequence
Protein Accession ft NP_439892 1
1 11 21 31 41 51
I I I I I I
MENFQKVEKI GEGTYGWYK ARNKLTGEW ALKKIRLDTE TEGVPSTAIR EISLLKELNH 60
PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS 120
HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEVTRRALFP GDSEIDQLFR 180
IFRTLGTPDE WWPGVTSMP DYKPSFPKWA RQDFSKWPP LDEDGRSLLS QMLHYDPYKR 240
ISAKAALAHP FFQDVTKPVP HLRL 264
Seq ID NO 345 Protein Sequence
Protein Accession ft NP_116127 1
1 11 21 31 41 51
I I I I I I
MKLGCVLMAW ALYLSLGVLW VAQMLLAASF ETLQCEGPVC TEESSCHTED DLTDAREAGF 60
QVKAYTFSEP FHLIVSYDWL ILQGPAKPVF EGDLLVLRCQ AWQDWPLTQV TFYRDGSALG 120
PPGPNREFSI TWQKADSGH YHCSGIFQSP GPGIPETASV VAITVQELFP APILRAVPSA 180
EPQAGSPMTL SCQTKLPLQR SAARLLFSFY KDGRIVQSRG LSSEFQIPTA SEDHSGSYWC 240
EAATEDNQVW KQSPQLEIRV QGASSSAAPP TLNPAPQKSA APGTAPEEAP GPLPPPPTPS 300
SEDPGFSSPL GMPDPHLYHQ MGLLLKHMQD VRVLLGHLLM ELRELSGHQK PGTTKATAE 359
Seq ID NO 346 Protein Sequence
Protein Accession ft NP_002337 1
1 11 21 31 41 51
I I I I I I
MKIFLPVLLA ALLGVERASS LMCFSCLNQK SNLYCLKPTI CSDQDNYCVT VSASAGIGNL 60 VTFGHSLSKT CSPACPIPEG VNVGVASMGI SCCQSFLCNF SAADGGLRAS VTLLGAGLLL 120 SLLPALLRFG P 131
Seq ID NO 347 Protein Sequence Protem Accession If XP_113526 2
1 11 21 31 41 51 I I I I I I
MEDLGENTMV LSTLRSLNNF ISQRVEGGSG LDISTSAPGS LQMQYQQSMQ LEERAEQIRS 60
KSHLIQVERE KMQMELSHKR ARVELERAAS TSARNYEREV DRNQELLTRI RQLQEREAGA 120
EEKMQEQLER NRQCQQNLDA ASKRLREKED SLAQAGETIN ALKGRISELQ WSVMDQEMRV 180
KRLESEKQEL QEQLDLQHKK CQEANQKIQE LQASQEARAD HEQQIKDLEQ KLSLQEQDAA 240
IVKNMKSELV RLPRLERELK QLREESAHLR EMRETNGLLQ EELEGLQRKL GRQEKMQETL 300
VGLELENERL LAKLQSWERL DQTMGLSIRT PEDLSRFWE LQQRELALKD KNSAVTSSAR 360
GLEKARQQLQ EELRQVSGQL LEERKKRETH EALARRLQKR VLLLTKERDG MRAILGSYDS 420
ELTPAEYSPQ LTRRMREAED MVQKVHSHSA EMEAQLSQAL EELGGQKQRA DMLEMELKML 480
KSQSSSAEQΞ FLFSREEADT LRLKVEELEG ERSRLEEEKR MLEAQLERRA LQGDYDQSRT 540
KVLHMSLNPT SVARQRLRED HSQLQAECER LRGLLRAMER GGTVPADLEA AAASLPSΞKE 600
VAELKKQVES AELKNQRLKE VFQTKIQEFR KACYTLTGYQ IDITTENQYR LTSLYAEHPG 660
DCLIFKATSP SGSKMQLLET EFSHTVGELI EVHLRRQDSI PAFLSSLTLE LFSRQTVA 718
Seq ID NO 348 Protein Sequence Protein Accession H NP_000264 1
1 11 21 31 41 51
I I I I I I
MTQAGRRGPG TPEPRPRTQP MASPRLGTFC CPTRDAATQL VLSFQPRAFH ALCLGSGGLR 60
LALGLLQLLP GRRPAGPGSP ATSPPASVRI LRAAAACDLL GCLGMVIRST VWLGFPNFVD 120 SVSDMNHTEI WPAAFCVGSA MWIQLLYSAC FWWLFCYAVD AYLVIRRSAG LSTILLYHIM 180
AWGLATLLCV EGAAMLYYPS VSRCERGLDH AIPHYVTMYL PLLLVLVANP ILFQKTVTAV 240
ASLLKGRQGI YTENERRMGA VIKIRFFKIM LVLIICWLSN IINESLLFYL EMQTDINGGS 300
LKPVRTAAKT TWFIMGILNP AQGFLLSLAF YGWTGCSLGF QSPRKEIQWE SLTTSAAEGA 360
HPSPLMPHEN PASGKVSQVG GQTSDEALSM LSEGSDASTI EIHTASESCN KNEGDPALPT 420
HGDL 424
Seq ID NO 349 Protein Sequence
Protein Accession ft NP_647478 1
1 11 21 31 41 51
I I I I I I
MGPKDSAKCL HRGPQPSHWA AGDGPTQERC GPRSLGSPVL GLDTCRAWDH VDGQILGQLR 60
PLTEEEEEEG AGATLSRGPA FPGMGSEELR LASFYDWPLT AEVPPELLAA AGFFHTGHQD 120
KVRCFFCYGG LQSWKRGDDP WTEHAKWFPS CQFLLRSKGR DFVHSVQETH SQLLGSWDPW 180
EEPEDAAPVA PSVPASGYPE LPTPRREVQS ESAQEPGGVS PAEAQRAWWV LEPPGARDVE 240
AQLRRLQEER TCKVCLDRAV SIVFVPCGHL VCAECAPGLQ LCPICRAPVR SRVRTFLS 298
Seq ID NO 350 Protein Sequence
Protein Accession ft NP_071444 1
1 11 21 31 41 51
I I I I I I
MGPKDSAKCL HRGPQPSHWA AGDGPTQERC GPRSLGSPVL GLDTCRAWDH VDGQILGQLR 60
PLTEEEEEEG AGATLSRGPA FPGMGSEELR LASFYDWPLT AEVPPELLAA AGFFHTGHQD 120
KVRCFFCYGG LQSWKRGDDP WTEHAKWFPS CQFLLRSKGR DFVHSVQETH SQLLGSWDPW 180
EEPEDAAPVA PSVPASGYPE LPTPRREVQS ESAQEPGARD VEAQLRRLQE ERTCKVCLDR 240
AVSIVFVPCG HLVCAECAPG LQLCPICRAP VRSRVRTFLS 280
Seq ID NO 351 Protein Sequence
Protein Accession tt NP_066300 1
1 11 21 31 41 51
I I I I I I
MGSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS GHGKSSΞKMG 60
KSEDFFYIKV SQKARGSHHP DYTALSSGDL GGQAGVDFDP STPPKLMPFS NQLEMGSEKG 120
AVRPTAFKPV LPRSGAILHS SPESASHQLH PAPPDKPKEQ ELKPGLCSGA LSDSGRNSMS 180 SLPTHSTSSS YQLDPLVTPV GPTSRFGGSA HNITQGIVLQ DSNMMSLKAL SFSDGGSKLG 240
HSNKADKGPS CVRSPISTDE CΞIQELEQKL LEREGALQKL QRSFEEKELA SSLAYEERPR 300
RCRDELEGPE PKGGNKLKQA SQKSQRAQQV LHLQVLQLQQ EKRQLRQELE SLMKEQDLLE 360
TKLRSYEREK TSFGPALEET QWEVCQKSGE ISLLKQQLKE SQTEVNAKAS EILGLKAQLK 420
DTRGKLEGLE LRTQDLEGAL RTKGLELEVC ENELQRKKNE AELLREKVNL LEQELQELRA 480
QAALARDMGP PTFPEDVPAL QRELERLRAE LREERQGHDQ MSSGFQHERL VWKEEKEKVI 540
QYQKQLQQSY VAMYQRNQRL EKALQQLARG DSAGEPLEVD LEGADIPYED IIATEI 596
Seq ID NO 352 Prote Sequence Protein Accession If AAG41361 1 1 11 21 31 41 51
I I I I I I
MPKNSKWKR ELDDDVTESV KDLLSNEDAA DDAFKTSELI VDGQEEKDTD VEEGSEVEDE 60
RPAWNSKLQY ILAQVGFSVG LGNVWRFPYL CQKNGGGAYL LPYLILLMVI GIPLFFLELS 120
VGQRIRRGSI GVWNYISPKL GGIGFASCW CYFVALYYNV IIGWSLFYFS QSFQQPLPWD 180
QCPLVKNASH TFVEPECEQS SATTYYWYRE ALNISSSISE SGGLNWKMTI CLLAAWVMVC 240
LAMIKGIQSS GKIIYFSSLF PYWLICFLI RAFLLNGSID GIRHMFTPKL EIMLEPKVWR 300
EAATQVFFAL GLGFGGVIAF SSYNKRDNNC HFDAVLVSFI NFFTSVLATL WFAVLGFKA 360
NVINEKCITQ NSETIMKFLK MGNISQDIIP HHINLSTVTA EDYHLVYDII QKVKEEEFPA 420
LHLNSCKIEE ELNKAVQGTG LAFIAFTEAM THFPASPFWS VMFFLMLVNL GLGSMFGTIE 480
GIVTPIVDTF KVRKEILTVI CCLLAFCIGL IFVQRSGNYF VTMFDDYSAT LPLLIWILE 540
NIAVCFVYGI DKFMEDLKDM LGFAPSRYYY YMWKYISPLM LLSLLIAS NMGLSPPGYN 600
AWIEDKASEE FLSYPTWGLV VCVSLWFAI LPVPWFIVR RFNLIDDSSG NLASVTYKRG 660
RVLKEPVNLE GDDTSLIHGK IPSEMPSPNF GKNIYRKQSG SPTLDTAPNG RYGIGYLMAD 720
IMPDMPESDL 730
Seq ID NO 353 Protein Sequence
Protein Accession ft NP_005594 1
1 11 21 31 41 51
I I I I I I
MEEGERSPLL SQETAGQKPL SVHRPPTSGC LGPVPREDQA EAWGCSCCPP ETKHQALSGT 60
PKKGPAPSLS PGSSCVKYLI FLSNFPFSLL GLLALAIGLW GLAVKGSLGS DLGGPLPTDP 120
MLGLALGGLV VSAASLAGCL GALCENTCLL RGFSGGILAF LVLEAVAGAL WALWGPLQD 180
SLEHTLRVAI AHYQDDPDLR FLLDQVQLGL RCCGAASYQD WQQNLYFNCS SPGVQACSLP 240
ASCCIDPRED GASVNDQCGF GVLRLDADAA QRWYLEGCG PPLRRWLRAN LAASGGYAIA 300
WLLQGAELL LAARLLGALA ARSGAAYGPG AHGEDRAGPQ SPSPGAPPAA KPARG 355
Seq ID NO 354 Protein Sequence Protein Accession If AAL84622 1
1 11 21 31 41 51 I I I I I I
MADPEVWSS CSSHEEENRC NFNQQTSPSE ELLLEDQMRR KLKFFFMNPC EKFWARGRKP 60
WKLAIQILKI AMVTIQLVLF GLSNQMWAF KEENTIAFKH LFLKGYMDRM DDTYAVYTQS 120
DVYDQLIFAV NQYLQLYNVS VGNHAYENKG TKQSAMAICQ HFYKRGNIYP GNDTFDIDPE 180
IETECFFVEP DEPFHIGTPA ENKLNLTLDF HRLLTVELQF KLKAINLQTV RHQELPDCYD 240
FTLTITFDNK AHSGRIKISL DNDISIRECK DWHVSGSIQK NTHYMMIFDA FVILTCLVSL 300
ILCIRSVIRG LQLQQEFVNF FLLHYKKEVS VSDQMEFVNG WYIMIIISDI LTIIGSILKM 360
EIQAKSLTSY DVCSILLGTS TMLVWLGVIR YLGFFAKYNL LILTLQAALP NVIRFCCCAA 420
MIYLGYCFCG WIVLGPYHDK FRSLNMVSEC LFSLINGDDM FATFAKMQQK SYLVWLFSRI 480
YLYSFISLFI YMILSLFIAL ITDTYETIKQ YQQDGFPETE LRTFISECKD LPNSGKYRLE 540 DDPPVSLFCC CKK 553
Seq ID NO 3SS Protein Sequence Protein Accession # NP_000105 1 1 11 21 31 41 51
I I I I I I
MEPGLWLLFG LTVTSAAGFV PCSQSGDAGR RGVSQAPTAA RSEGDCEETV AGPGEETVAG 60
PGEGTVAPTA LQGPSPGSPG QEQAAEGAPE HHRSRRCTCF TYKDKECVYY CHLDIIWINT 120
PEQTVPYGLS NYRGSFRGKR SAGPLPGNLQ LSHRPHLRCA CVGRYDKACL HFCTQTLDVS 180 SNSRTAEKTD KEEEGKVEVK DQQSKQALDL HHPKLMPGSG LALAPSTCPR CLFQEGAP 238
Seq ID NO 3S6 Prote Sequence
Protein Accession ft NP_005347 2
1 11 21 31 41 51 I I I I I I
MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP 60
LQDNLVIALH SYEPSHDGDL GFEKGEPLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 120
SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGE KH 180
YKIRNLDNGG FYISPRITFP GLHELVRHYT NASDGLCTRL SRPCQTQKPQ KPWWEDEWEV 240 PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL 300
VRLYAWTQE PIYIITEYME NGSLVDFLKT PSGIKLTINK LLDMAAQIAE GMAFIEERNY 360
IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK 420
SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY QLMRLCWKER 480 PEDRPTFDYL RSVLEDFFTA TEGQYQPQP 509
Seq ID NO 357 Protein Sequence
Protein Accession II NP_055469 1
1 11 21 31 41 51
I I I I I I
MAIAYLGSSC PSQPPSSLAL SLSPTPSDFE QESGIETAMR FSPDVALAVS TTPAVLPTTN 60
IQPVGTPFEE LPSERPTLEP ATSPL TEV PEEPSQRATT VSTTMATTAA TSTGDPTVAT 120
VPATVATATP STPAAPPFTA TTAVIRTTGV RRLLPLPLTT VATARATTPE APSPPTTAAV 180
LDTEAPTPRL VSTATSRPRA LPRPATTQEP DIPERSTLPL GTTAPGPTEV AQTPTPETFL 240
TTIRDEPEVP VSGGPSGDFE LPEEETTQPD TANE AVGG AAAKASSPPG TLPKGARPGP 300
GLLDNAIDSG SSAAQLPQKS ILERKEVLVA VIVGGWGAL FAAFLVTLLI YRMKKKDEGS 360
YTLEEPKQAS VTYQKPDKQE EFYA 384
Seq ID NO 358 Protein Sequence Protein Accession tt NP_008848 1 1 11 21 31 41 51
I I I I I I
MYGNYSHFMK FPAGYGGSPG HTGSTSMSPS AALSTGKPMD SHPSYTDTPV SAPRTLSAVG 60
TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL NWNSVSSSE DIKPLPGLPG 120
IGNMNYPSTS PGSLVKHICA ICGDRSSGKH YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD 180 CLIDKRQRNR CQYCRYQKCL VMGMKREAVQ EERQRSRERA ESEAECATSG HEDMPVERIL 240
EAELAVEPKT ESYGDMNMEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI 300
LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV LTELVSKMKD 360
MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT LEAYTKQKYP EQPGRFAKLL 420
LRLPALRSIG LKCLEHLFFF KLIGDTPIDT FLMEMLETPL QIT 463
Seq ID NO 359 Protein Sequence
Protein Accession ft NP_002176 1
1 11 21 31 41 51
I I I I I I
MTILGTTFGM VFSLLQ SG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE 60
DPDVNTTNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK 120
IDLTTIVKPE APFDLSVIYR EGANDFWTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH 180
VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP 240
ILLTISILSF FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKNLNVSFNP 300
ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP SEDVWTPES 360
FGRDSSLTCL AGNVSACDAP ILSSSRSLDC RESGKNGPHV YQDLLLSLGT TNSTLPPPFS 420
LQSGILTLNP VAQGQPILTS LGSNQEEAYV TMSSFYQNQ 459
Seq ID NO 360 Protein Sequence Protein Accession ft NP_006263 1
1 11 21 31 41 51
I I I I I I
MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE QEWDKVMET 60
LDNDGDGECD FQEFMAFVAM VTTACHEFFE HE 92
Seq ID NO 361 Protein Sequence Protein Accession tt NP_006148 1
1 11 21 31 41 51
I I I I I I
MPMDLILWW FCVCTARTW GFGMDPDLQM DIVTELDLVN TTLGVAQVSG MHNASKAFLF 60
QDIEREIHAA PHVSEKLIQL FQNKSEFTIL ATVQQKPSTS GVILSIRELE HSYFELESSG 120
LRDEIRYHYI HNGKPRTEAL PYRMADGQWH KVALSVSASH LLLHVDCNRI YERVIDPPDT 180
NLPPGINLWL GQRNQKHGLF KGIIQDGKII FMPNGYITQC PNLNHTCPTC SDFLSLVQGI 240
MDLQELLAKM TAKLNYAETR LSQLENCHCE KTCQVSGLLY RDQDSWVDGD HCRNCTCKSG 300
AVECRRMSCP PLNCSPDSLP VHIAGQCCKV CRPKCIYGGK VLAEGQRILT KSCRECRCCV 360
LVKITEMCPP LNCSEKDHIL PENQCCRVCR GHNFCAEGPK CGENSECKNW NTKATCECKS 420
GYISVQGDSA YCEDIDECAA KMHYCHANTV CVNLPGLYRC DCVPGYIRVD DFSCTEHDEC 480 GSGQHNCDEN AICTNTVQGH SCTCKPGYVG NGTICRAFCE EGCRYGGTCV APNKCVCPSG 540
FTGSHCEKDI DECSEGIIEC HNHSRCVNLP GWYHCECRSG FHDDGTYSLS GESCIDIDEC 600
ALRTHTCWND SACINLAGGF DCLCPSGPSC SGDCPHEGGL KHNGQVWTLK EDRCSVCSCK 660
DGKIFCRRTA CDCQNPSADL FCCPECDTRV TSQCLDQNGH KLYRSGDNWT HSCQQCRCLE 720
GEVDCWPLTC PNLSCEYTAI LEGECCPRCV SDPCLADNIT YDIRKTCLDS YGVSRLSGSV 780
WTMAGSPCTT CKCKNGRVCC SVDFECLQNN 810
Seq ID NO: 362 Protein Sequence
Protein Accession It: NP_057264 1
1 11 21 31 41 51
I I I I I I
MGSNSGQAGR HIYKSLADDG PFDSVEPPKR PTSRLIMHSM AMFGREFCYA VEAAYVTPVL 60
LSVGLPSSLY SIVWFLSPIL GFLLQP GS ASDHCRSRWG RRRPYILTLG VMMLVGMALY 120
LNGATWAAL IANPRRKLVW AISVTMIG LFDFAADFID GPIKAYLFDV CSHQDKEKGL 180
HYHALFTGFG GALGYLLGAI DWAHLELGRL LGTEFQVMFF FSALVLTLCF TVHLCSISEA 240
PLTEVAKGIP PQQTPQDPPL SSDGMYEYGS IEKVKNGYVN PELAMQGAKN KNHAEQTRRA 300
MTLKSLLRAL VNMPPHYRYL CISHLIGWTA FLSNMLFFTD FMGQIVYRGD PYSAHNSTEF 360
LIYERGVEVG CWGFCINSVF SSLYSYFQKV LVSYIGLKGL YFTGYLLFGL GTGFIGLFPN 420
VYSTLVLCSL FGVMSSTLYT VPFNLITEYH REEEKERQQA PGGDPDNSVR GKGMDCATLT 480 CMVQLAQILV GGGLGFLVNT AGTWVWIT ASAVALIGCC FVALFVRYVD 530
Seq ID NO: 363 Protein Sequence
Protein Accession If: NP_036532.1
1 11 21 31 41 51 i i i i i i
MELALLCGLV VMAGVIPIQG GILNLNKMVK QVTGKMPILS YWPYGCHCGL GGRGQPKDAT 60
DWCCQTHDCC YDHLKTQGCS IYKDYYRYNF SQGNIHCSDK GSWCEQQLCA CDKEVAFCLK 120
RNLDTYQKRL RFYWRPHCRG QTPGC 145 Seq ID NO 364 Protein Sequence Protem Accession ft- NP_061313.1 1 11 21 31 41 51
I I I I I I
MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW GLLKLRGLLG 60 FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS WLLVGYGAAG LSWSLWAVLS 120
PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP LLVAAFFFLV LAVLGETLIP HYSGRVIDIL 180
GGDFDPHAFA SAIFFMCLFS FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF 240
FQETKTGELN SRLSSDTTLM SNWLPLNANV LLRSLVKWG LYGFMLSISP RLTLLSLLHM 300
PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ WREAVGGLQ TVRSFGAEEH EVCRYKEALE 360 QCRQLYWRRD LERALYLLIR RVLHLGVQML MLSCGLQQMQ DGELTQGSLL SFMIYQESVG 420
SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ PNLPSPGTLA PTTLQGWKF QDVSFAYPNR 480
PDRPVLKGLT FTLRPGEVTA LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC 540
YLHSQWSVG QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV 600
GEKGSQLAAG QKQRLAIARA LVRDPRVLIL 630
Seq ID NO 365 Protein Sequence
Protein Accession ft- NP_002407
1 11 21 31 41 51
I I I I I I
MKKSGVLFLL GIILLVLIGV QGTPWRKGR CSCISTNQGT IHLQSLKDLK QFAPSPSCEK 60 IEIIATLKNG VQTCLNPDSA DVKELIKKWE KQVSQKKKQK NGKKHQKKKV LKVRKSQRSR 120 QKKTT
Seq ID NO. 366 Protein Sequence
Protein Accession ft: NP_006524 1
1 11 21 31 41 51
I I I I I I
MARSLVCLGV IILLSAFSGP GVRGGPMPKL ADRKLCADQE CSHPISMAVA LQDYMAPDCR 60
FLTIHRGQW YVFSKLKGRG RLFWGGSVQG DYYGDLAARL GYFPSSIVRE DQTLKPGKVD 120
VKTDKWDFYC Q 131
It is understood that the examples described above in no way serve to limit the true scope of this invention, but rather are presented for illustrative puφoses. All publications, sequences of accession numbers, and patent applications cited in this specification are herein incoφorated by reference as if each individual publication or patent application were specifically and individually indicated to be incoφorated by reference.

Claims

WHAT IS CLAIMED IS:
1. A method for determining the presence or absence of a pathological cell in a patient, said method comprising detecting a nucleic acid comprising a sequence at least 80% identical to a sequence as described in Tables 2A-68 in a biological sample from said patient, thereby determining the presence or absence of said pathological cell.
2. The method of Claim 1, wherein: a) said pathology is described in Table 1 , including a cancer; and/or b) said biological sample comprises isolated nucleic acids.
3. The method of Claim 1, wherein said biological sample is tissue from an organ which is affected by said pathology of Table 1, including a cancer.
4. The method of Claim 2, wherein said nucleic acids are mRNA
5. The method of Claim 2: a) further comprising a step of amplifying nucleic acids before said step of detecting said nucleic acid; or b) where said detecting is of a protein encoded by said nucleic acid.
6. The method of Claim 1, wherein said nucleic acid comprises a sequence as described in Tables 2A-68.
7. The method of Claim 2, wherein: a) said detecting step is carried out by: i) using a labeled nucleic acid probe; ii) utilizing a biochip comprising a sequence at least 80% identical to a sequence as described in Tables 2A-68; or iii) detecting a polypeptide encoded by said nucleic acid; or b) said patient is: i) undergoing a therapeutic regimen to treat said pathology of Table 1 ; or ii) is suspected of having said pathology or cancer.
8. An isolated nucleic acid molecule comprising a sequence as described in Tables 2A-68.
9. The nucleic acid molecule of Claim 8, which is labeled.
10. An expression vector comprising the nucleic acid of Claim 8.
11. A host cell comprising the expression vector of Claim 10.
12. An isolated polypeptide which is encoded by a nucleic acid molecule comprising a sequence as described in Tables 2A-68.
13. An antibody that specifically binds a polypeptide of Claim 12.
14. The antibody of Claim 13: a) conjugated to an effector component; b) conjugated to a detectable label, including a fluorescent label, a radioisotope, or a cytotoxic chemical; c) which is an antibody fragment; or d) which is a humanized antibody.
15. A method for specifically targeting a compound to a pathological cell in a patient, said method comprising administering to said patient an antibody of Claim 13, thereby providing said targetting.
16. A method for determining the presence or absence of a pathological cell in a patient, said method comprising contacting a biological sample with an antibody of Claim 13.
17. The method of Claim 16, wherein: a) said antibody is conjugated to: i) an effector component; or ii) a fluorescent label; or b) said biological sample is a blood, serum, urine, or stool sample.
18. A method for identifying a compound that modulates a pathology-associated polypeptide, said method comprising the steps of: a) contacting said compound with a pathology-associated polypeptide, said polypeptide encoded by a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as described in Tables 2A-68; and b) determining the functional effect of said compound upon said polypeptide.
19. A drug screening assay comprising the steps of: a) administering a test compound to a mammal having a pathology of Table 1 or a cell isolated therefrom; and b) comparing the level of gene expression of a polynucleotide that selectively hybridizes to a sequence at least 80% identical to a sequence as described in Tables 2A-68 in a treated cell or mammal with the level of gene expression of said polynucleotide in a control cell or mammal, wherein a test compound that modulates said level of expression of the polynucleotide is a candidate for the treatment of said pathology.
PCT/US2002/029560 2001-09-17 2002-09-17 Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer WO2003025138A2 (en)

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EP02766297A EP1434881A4 (en) 2001-09-17 2002-09-17 Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer
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US60/323,469 2001-09-17
US32388701P 2001-09-20 2001-09-20
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US35066601P 2001-11-13 2001-11-13
US60/350,666 2001-11-13
US35525702P 2002-02-08 2002-02-08
US35514502P 2002-02-08 2002-02-08
US60/355,257 2002-02-08
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