RU2017124859A - Полученные с помощью генной инженерии антитела с цистеиновыми заменами и их конъюгаты - Google Patents
Полученные с помощью генной инженерии антитела с цистеиновыми заменами и их конъюгаты Download PDFInfo
- Publication number
- RU2017124859A RU2017124859A RU2017124859A RU2017124859A RU2017124859A RU 2017124859 A RU2017124859 A RU 2017124859A RU 2017124859 A RU2017124859 A RU 2017124859A RU 2017124859 A RU2017124859 A RU 2017124859A RU 2017124859 A RU2017124859 A RU 2017124859A
- Authority
- RU
- Russia
- Prior art keywords
- conjugates
- genetic engineering
- antibodies obtained
- cysteine
- cysteine replacements
- Prior art date
Links
- 235000018417 cysteine Nutrition 0.000 title claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 title claims 2
- 238000010353 genetic engineering Methods 0.000 title 1
- 235000001014 amino acid Nutrition 0.000 claims 2
- -1 free cysteine amino acid Chemical class 0.000 claims 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Claims (1)
- Выделенное, полученное с помощью генной инженерии антитело с цистеиновыми заменами, содержащее свободную цистеиновую аминокислоту и последовательность тяжелой цепи, выбранную из SEQ ID NO:50-98, или последовательность легкой цепи, выбранную из SEQ ID NO:99-147, где цистеин в последовательности представляет собой свободную цистеиновую аминокислоту.
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RU2012156248A RU2626537C2 (ru) | 2010-06-08 | 2011-06-07 | Полученные с помощью генной инженерии антитела с цистеиновыми заменами и их конъюгаты |
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