ATE483976T1 - Gfats als modifikatoren des p53-wegs und verwendungsverfahren - Google Patents

Gfats als modifikatoren des p53-wegs und verwendungsverfahren

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Publication number
ATE483976T1
ATE483976T1 AT02749774T AT02749774T ATE483976T1 AT E483976 T1 ATE483976 T1 AT E483976T1 AT 02749774 T AT02749774 T AT 02749774T AT 02749774 T AT02749774 T AT 02749774T AT E483976 T1 ATE483976 T1 AT E483976T1
Authority
AT
Austria
Prior art keywords
methods
gfats
pathway
pathway modifiers
modifiers
Prior art date
Application number
AT02749774T
Other languages
English (en)
Inventor
Lori Friedman
Gregory Plowman
Marcia Belvin
Helen Francis-Lang
Danxi Li
Roel Funke
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Application granted granted Critical
Publication of ATE483976T1 publication Critical patent/ATE483976T1/de

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
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    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
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    • C—CHEMISTRY; METALLURGY
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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT02749774T 2001-06-05 2002-06-02 Gfats als modifikatoren des p53-wegs und verwendungsverfahren ATE483976T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29607601P 2001-06-05 2001-06-05
US32860501P 2001-10-10 2001-10-10
US35725302P 2002-02-15 2002-02-15
PCT/US2002/021112 WO2002099083A2 (en) 2001-06-05 2002-06-02 Gfats as modifiers of the p53 pathway and methods of use

Publications (1)

Publication Number Publication Date
ATE483976T1 true ATE483976T1 (de) 2010-10-15

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AT02749774T ATE483976T1 (de) 2001-06-05 2002-06-02 Gfats als modifikatoren des p53-wegs und verwendungsverfahren

Country Status (8)

Country Link
US (7) US20030013144A1 (de)
EP (7) EP1456650B1 (de)
JP (7) JP2005501528A (de)
AT (1) ATE483976T1 (de)
AU (17) AU2002320264B2 (de)
CA (7) CA2449289A1 (de)
DE (1) DE60237917D1 (de)
WO (27) WO2002099044A2 (de)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2449275A1 (en) * 2001-06-05 2002-12-12 Exelixis, Inc. Dgks as modifiers of the p53 pathway and methods of use
WO2003003016A1 (en) * 2001-06-27 2003-01-09 The Walter And Eliza Hall Institute Of Medical Research Diagnostic methods and agents
WO2003074674A2 (en) * 2002-03-01 2003-09-12 Exelixis, Inc. MSRAs AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE
GB0207533D0 (en) 2002-04-02 2002-05-08 Oxford Glycosciences Uk Ltd Protein
AU2003244191A1 (en) * 2002-06-26 2004-01-19 Takeda Pharmaceutical Company Preventives/remedies for cancer
FR2844713A1 (fr) * 2002-09-25 2004-03-26 Exonhit Therapeutics Sa Nouvelle cible de l'angiogenese et utilisations
US7358262B2 (en) 2003-01-29 2008-04-15 Whitehead Institute For Biomedical Research Identification of genotype-selective anti-tumor agents
WO2004067721A2 (en) * 2003-01-29 2004-08-12 Exelixis Inc. Tkts as modifiers of the beta-catenin pathway and methods of use
US7767387B2 (en) * 2003-06-13 2010-08-03 Sagres Discovery, Inc. Therapeutic targets in cancer
DE602004021778D1 (de) * 2003-02-27 2009-08-13 Basf Se Modifizierte nitrilasen und deren verwendung in verfahren zur herstellung von carbonsäuren
JP2007525962A (ja) * 2003-06-19 2007-09-13 エクセリクシス， インク． ＰＴＥＮ／ＩＧＦ経路のモディファイヤーとしてのＭＰＴＥＮｓおよび使用方法
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