ATE483976T1 - Gfats als modifikatoren des p53-wegs und verwendungsverfahren - Google Patents

Gfats als modifikatoren des p53-wegs und verwendungsverfahren

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Publication number
ATE483976T1
ATE483976T1 AT02749774T AT02749774T ATE483976T1 AT E483976 T1 ATE483976 T1 AT E483976T1 AT 02749774 T AT02749774 T AT 02749774T AT 02749774 T AT02749774 T AT 02749774T AT E483976 T1 ATE483976 T1 AT E483976T1
Authority
AT
Austria
Prior art keywords
methods
gfats
pathway
pathway modifiers
modifiers
Prior art date
Application number
AT02749774T
Other languages
English (en)
Inventor
Lori Friedman
Gregory Plowman
Marcia Belvin
Helen Francis-Lang
Danxi Li
Roel Funke
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Application granted granted Critical
Publication of ATE483976T1 publication Critical patent/ATE483976T1/de

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT02749774T 2001-06-05 2002-06-02 Gfats als modifikatoren des p53-wegs und verwendungsverfahren ATE483976T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29607601P 2001-06-05 2001-06-05
US32860501P 2001-10-10 2001-10-10
US35725302P 2002-02-15 2002-02-15
PCT/US2002/021112 WO2002099083A2 (en) 2001-06-05 2002-06-02 Gfats as modifiers of the p53 pathway and methods of use

Publications (1)

Publication Number Publication Date
ATE483976T1 true ATE483976T1 (de) 2010-10-15

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AT02749774T ATE483976T1 (de) 2001-06-05 2002-06-02 Gfats als modifikatoren des p53-wegs und verwendungsverfahren

Country Status (8)

Country Link
US (7) US20030036076A1 (de)
EP (7) EP1456650B1 (de)
JP (7) JP2005501528A (de)
AT (1) ATE483976T1 (de)
AU (17) AU2002320264B2 (de)
CA (7) CA2449289A1 (de)
DE (1) DE60237917D1 (de)
WO (27) WO2002099083A2 (de)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005505257A (ja) * 2001-06-05 2005-02-24 エクセリクシス・インコーポレイテッド ｐ５３経路のモディファイヤーとしてのＩＧｓおよび使用方法
CA2452202A1 (en) * 2001-06-27 2003-01-09 The Walter And Eliza Hall Institute Of Medical Research Diagnostic methods and agents
AU2003224638A1 (en) * 2002-03-01 2003-09-16 Exelixis, Inc. PDPK1s AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE
GB0207533D0 (en) 2002-04-02 2002-05-08 Oxford Glycosciences Uk Ltd Protein
AU2003244191A1 (en) * 2002-06-26 2004-01-19 Takeda Pharmaceutical Company Preventives/remedies for cancer
FR2844713A1 (fr) * 2002-09-25 2004-03-26 Exonhit Therapeutics Sa Nouvelle cible de l'angiogenese et utilisations
US7358262B2 (en) 2003-01-29 2008-04-15 Whitehead Institute For Biomedical Research Identification of genotype-selective anti-tumor agents
CA2513601A1 (en) * 2003-01-29 2004-08-12 Exelixis, Inc. Tkts as modifiers of the beta-catenin pathway and methods of use
US7767387B2 (en) * 2003-06-13 2010-08-03 Sagres Discovery, Inc. Therapeutic targets in cancer
WO2004076655A1 (en) * 2003-02-27 2004-09-10 Basf Aktiengesellschaft Modified nitrilases and their use in methods for the production of carboxylic acids
US8273536B2 (en) 2003-06-19 2012-09-25 Exelixis, Inc. Marks as modifers of the PTEN pathway and methods of use
EP1633880A4 (de) * 2003-06-19 2006-11-08 Exelixis Inc Mptene als modifikatoren des pten/igf-wegs und verwendungsverfahren
US7435808B2 (en) 2003-06-25 2008-10-14 Bristol-Myers Squibb Company Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2
WO2005026737A2 (en) * 2003-09-18 2005-03-24 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with organic cation transporter slc22a4 (slc22a4)
WO2005029085A2 (en) * 2003-09-22 2005-03-31 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with organic cation transporter slc22a11 (slc22a11)
ATE554393T1 (de) * 2003-09-27 2012-05-15 Siemens Healthcare Diagnostics Diagnostika und therapeutika für mit adiponectin receptor 2 (adipor2) assoziierten erkrankungen
WO2005040830A1 (en) * 2003-10-21 2005-05-06 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with organic cationic transporter-like 3 (orctl3) (orctl3)
WO2005040827A2 (en) * 2003-10-21 2005-05-06 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with organic cationic transporter-like 4 (orctl4) (orctl4)
BR122018071808B8 (pt) 2003-11-06 2020-06-30 Seattle Genetics Inc conjugado
WO2005052132A2 (en) * 2003-11-24 2005-06-09 Exelixis, Inc Mbms as modifiers of branching morphogenesis and methods of use
GB0328928D0 (en) * 2003-12-12 2004-01-14 Cancer Rec Tech Ltd Materials and methods relating to cell cycle control
US8415315B2 (en) 2004-05-06 2013-04-09 University Of Central Florida Research Foundation, Inc. Methods and compositions for inhibiting the proliferation of cancer cells
EP1761784B1 (de) * 2004-05-24 2016-10-26 Universität Zu Köln Identifizierung des ergothionein-transporters und therapeutische verwendungen davon
BRPI0510883B8 (pt) 2004-06-01 2021-05-25 Genentech Inc composto conjugado de droga e anticorpo, composição farmacêutica, método de fabricação de composto conjugado de droga e anticorpo e usos de uma formulação, de um conjugado de droga e anticorpo e um agente quimioterapêutico e de uma combinação
AU2005287169A1 (en) * 2004-09-17 2006-03-30 Exelixis, Inc. PIK4CA as modifier of the RAC pathway and methods of use
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
CN101065151B (zh) 2004-09-23 2014-12-10 健泰科生物技术公司 半胱氨酸改造的抗体和偶联物
MX2007006252A (es) 2004-11-24 2009-02-13 Theraptosis Sa Nuevos peptidos utiles como inhibidores duales de caspasa-2/-6 y sus aplicaciones biologicas.
EP1817059A2 (de) 2004-12-01 2007-08-15 Genentech, Inc. Konjugate von 1,8-bis-naphthalimiden mit einem antikörper
AU2005318836B2 (en) * 2004-12-21 2012-03-22 Viventia Bio Inc. Cancer specific antibody and cell surface proteins
NZ560320A (en) * 2005-01-25 2011-02-25 Prolexys Pharmaceuticals Inc Quinoxaline derivatives as antitumor agents
WO2006094293A2 (en) * 2005-03-03 2006-09-08 President And Fellows Of Harvard College Slim compositions and methods of use thereof
EP1734118A1 (de) * 2005-06-15 2006-12-20 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Genom-weites RNAi-Screening zur Identifizierung von Genen die das JAK/STAT Pathway modulieren
WO2007037538A1 (ja) * 2005-09-30 2007-04-05 Link Genomics, Inc. Ｓｐｏ１１遺伝子の治療的又は診断的用途
WO2007084486A2 (en) * 2006-01-13 2007-07-26 Battelle Memorial Institute Animal model for assessing copd-related diseases
JPWO2008068827A1 (ja) * 2006-12-01 2010-03-11 ジェイファーマ株式会社 腎臓特異性を有する新規な有機イオントランスポーター
EP1978105A1 (de) * 2007-04-04 2008-10-08 Deutsches Institut Für Ernährungsforschung - Stiftung Des Öffentlichen Rechts - Vertreten Durch Den Stiftungsvorstand TBC1D1 als Marker für die Reaktion auf Nahrungsfett und Fettleibigkeit
EP2023144A1 (de) * 2007-08-01 2009-02-11 Sanofi-Aventis Neues AS160-Protein, Testsysteme, Verfahren und Verwendungen bei der Identifizierung von Therapeutika gegen Typ-2-Diabetes
ES2557931T3 (es) 2007-08-08 2016-01-29 Lexicon Pharmaceuticals, Inc. (7H-Pirrolo[2,3-d]pirimidin-4-il)-piperazinas como inhibidores de cinasas para el tratamiento de cáncer e inflamación
CN101828114B (zh) * 2007-08-24 2015-03-11 Lsip基金运营联合公司 妇科癌症的检出方法
EP2674433A1 (de) 2008-04-21 2013-12-18 Lexicon Pharmaceuticals, Inc. LIMK2-Hemmer, Zusammensetzungen diese enthaltend und Verfahren zu deren Anwendung
AR072804A1 (es) 2008-07-15 2010-09-22 Genentech Inc Conjugados derivados de antraciclina,proceso para su preparacion,composiciones farmaceuticas que los contienen y su uso como agentes antitumorales.
US8470980B2 (en) 2009-09-09 2013-06-25 Centrose, Llc Extracellular targeted drug conjugates
EP2525794A1 (de) 2010-01-22 2012-11-28 Lexicon Pharmaceuticals, Inc. 5-(1h-pyrazol-5-yl)thiazol-basierte verbindungen zur behandlung von erkrankungen und leiden des auges
BR112012026213B1 (pt) 2010-04-15 2021-12-28 Medimmune Limited Compostos de pirrolobenzodiazepinas, conjugado das mesmas, composição farmacêutica compreendendo o conjugado e uso do mesmo para o tratamento de uma doença proliferativa
WO2011156328A1 (en) 2010-06-08 2011-12-15 Genentech, Inc. Cysteine engineered antibodies and conjugates
WO2012010240A1 (en) * 2010-07-19 2012-01-26 Cellzome Ag In vivo method for the evaluation of a compound-target interaction
CN103313990B (zh) 2010-11-17 2016-07-20 基因泰克公司 丙氨酰美登醇抗体偶联物
WO2012131297A1 (en) 2011-03-28 2012-10-04 Jonathan Bayldon Baell Pyrido [3',2' :4,5] thieno [3, 2-d] pyrimidin- 4 - ylamine derivatives and their therapeutical use
US8679767B2 (en) 2011-05-12 2014-03-25 Genentech, Inc. Multiple reaction monitoring LC-MS/MS method to detect therapeutic antibodies in animal samples using framework signature peptides
SG11201401406YA (en) 2011-10-14 2014-05-29 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
FR2984362B1 (fr) * 2011-12-20 2017-11-24 Biomerieux Sa Procede pour le diagnostic ou le pronostic in vitro du cancer du poumon
WO2013130093A1 (en) 2012-03-02 2013-09-06 Genentech, Inc. Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
WO2013138463A1 (en) * 2012-03-14 2013-09-19 University Of Central Florida Research Foundation, Inc. Neurofibromatoses therapeutic agents and screening for same
EP2906250B1 (de) 2012-10-12 2018-05-30 ADC Therapeutics SA Pyrrolobenzodiazepin-anti-psma-antikörperkonjugate
WO2014057074A1 (en) 2012-10-12 2014-04-17 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
SMT201800346T1 (it) 2012-10-12 2018-09-13 Medimmune Ltd Coniugati pirrolobenzodiazepina-anticorpo
US10695433B2 (en) 2012-10-12 2020-06-30 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
WO2014057122A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
SI2906253T1 (sl) 2012-10-12 2018-11-30 Adc Therapeutics Sa Konjugati pirolobenzodiazepin-protitelo proti PSMA
PT2906298T (pt) 2012-10-12 2018-12-28 Medimmune Ltd Conjugados de pirrolobenzodiazepina-anticorpos
US8959767B2 (en) 2012-11-21 2015-02-24 United Technologies Corporation Method of extending life of rotating parts
JP6307519B2 (ja) 2012-12-21 2018-04-04 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ピロロベンゾジアゼピンおよびその結合体
CN110627797A (zh) 2012-12-21 2019-12-31 麦迪穆有限责任公司 用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物
EP2968596B1 (de) 2013-03-13 2019-03-06 Medimmune Limited Pyrrolobenzodiazepine und konjugate davon
JP6340019B2 (ja) 2013-03-13 2018-06-06 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ピロロベンゾジアゼピン及びそのコンジュゲート
AU2014230735B2 (en) 2013-03-13 2018-03-15 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
US10442836B2 (en) 2013-08-12 2019-10-15 Genentech, Inc. 1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
EP3054985B1 (de) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepin-antikörper-konjugate
US10010624B2 (en) 2013-10-11 2018-07-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
WO2015052535A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
JP6980384B2 (ja) 2013-12-16 2021-12-15 ジェネンテック， インコーポレイテッド １−（クロロメチル）−２，３−ジヒドロ−１ｈ−ベンゾ［ｅ］インドール二量体抗体−薬物コンジュゲート化合物、並びに使用及び処置の方法
RU2689388C1 (ru) 2013-12-16 2019-05-28 Дженентек, Инк. Пептидомиметические соединения и их конъюгаты антител с лекарственными средствами
EA201691023A1 (ru) 2013-12-16 2016-10-31 Дженентек, Инк. Пептидомиметические соединения и их конъюгаты антитела с лекарственным средством
KR102775902B1 (ko) 2013-12-17 2025-03-06 크링 바이오테라퓨틱스 비.브이. 골수 증식성 또는 림프 증식성 질환에 대응하는 수단 및 방법
US10188746B2 (en) 2014-09-10 2019-01-29 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
JP6622293B2 (ja) 2014-09-12 2019-12-18 ジェネンテック， インコーポレイテッド アントラサイクリンジスルフィド中間体、抗体−薬物複合体、及び方法
MX2017003123A (es) 2014-09-12 2017-05-12 Genentech Inc Anticuerpos y conjugados modificados geneticamente con cisteina.
AU2015317653A1 (en) 2014-09-17 2017-04-06 Genentech, Inc. Pyrrolobenzodiazepines and antibody disulfide conjugates thereof
US10780096B2 (en) 2014-11-25 2020-09-22 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
JP6752204B2 (ja) 2014-12-03 2020-09-09 ジェネンテック， インコーポレイテッド 四級アミン化合物及びその抗体−薬物コンジュゲート
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
TWI747524B (zh) * 2015-06-19 2021-11-21 德商英麥提克生物技術股份有限公司 用於免疫治療的新穎胜肽及胜肽組合物與產生用於抗胰臟癌及其他癌症的支架的方法
MA43345A (fr) 2015-10-02 2018-08-08 Hoffmann La Roche Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation
MA43354A (fr) 2015-10-16 2018-08-22 Genentech Inc Conjugués médicamenteux à pont disulfure encombré
MA45326A (fr) 2015-10-20 2018-08-29 Genentech Inc Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
US20170315132A1 (en) 2016-03-25 2017-11-02 Genentech, Inc. Multiplexed total antibody and antibody-conjugated drug quantification assay
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
ES2858151T3 (es) 2016-05-20 2021-09-29 Hoffmann La Roche Conjugados de PROTAC-anticuerpo y procedimientos de uso
US20170370906A1 (en) 2016-05-27 2017-12-28 Genentech, Inc. Bioanalytical analysis of site-specific antibody drug conjugates
EP3464280B1 (de) 2016-06-06 2021-10-06 F. Hoffmann-La Roche AG Silvestrol-antikörper-arzneimittelkonjugate und verfahren zur verwendung
WO2018031662A1 (en) 2016-08-11 2018-02-15 Genentech, Inc. Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof
CN110139674B (zh) 2016-10-05 2023-05-16 豪夫迈·罗氏有限公司 制备抗体药物缀合物的方法
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
ES2871001T3 (es) 2017-02-08 2021-10-28 Adc Therapeutics Sa Conjugados de pirrolobenzodiazepinas y anticuerpos
WO2018192944A1 (en) 2017-04-18 2018-10-25 Medimmune Limited Pyrrolobenzodiazepine conjugates
CA3057748A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
ES2988683T3 (es) 2017-06-14 2024-11-21 Adc Therapeutics Sa Pautas posológicas para la administración de un CAF anti-CD19
SG11202000358YA (en) 2017-08-18 2020-02-27 Medimmune Ltd Pyrrolobenzodiazepine conjugates
KR20220156974A (ko) 2017-09-20 2022-11-28 주식회사 피에이치파마 타일란스타틴 유사체
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
GB201814281D0 (en) 2018-09-03 2018-10-17 Femtogenix Ltd Cytotoxic agents
EP3870235A1 (de) 2018-10-24 2021-09-01 F. Hoffmann-La Roche AG Konjugierte chemische abbauauslöser und verwendungsverfahren
EP3894427A1 (de) 2018-12-10 2021-10-20 Genentech, Inc. Photovernetzende peptide zur stellenspezifischen konjugation an fc-haltige proteine
GB201901197D0 (en) 2019-01-29 2019-03-20 Femtogenix Ltd G-A Crosslinking cytotoxic agents
MX2021010477A (es) 2019-03-15 2021-10-01 Medimmune Ltd Dimeros de azetidobenzodiazepina y conjugados que los comprenden para uso en el tratamiento de cancer.
GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
WO2022078524A2 (en) 2021-11-03 2022-04-21 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody
EP4637833A2 (de) 2022-12-23 2025-10-29 Genentech, Inc. Cereblon-abbaukonjugate und verwendungen davon
WO2024220546A2 (en) 2023-04-17 2024-10-24 Peak Bio, Inc. Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4870009A (en) 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
US4670388A (en) 1982-12-30 1987-06-02 Carnegie Institution Of Washington Method of incorporating DNA into genome of drosophila
US4736866A (en) 1984-06-22 1988-04-12 President And Fellows Of Harvard College Transgenic non-human mammals
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5235033A (en) * 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5421964A (en) * 1993-04-30 1995-06-06 E. I. Du Pont De Nemours And Company Process for separating HCl and halocarbons
US5989893A (en) * 1993-09-27 1999-11-23 University Of Massachusetts Medical Center Receptor-activated reporter systems
AU1211895A (en) * 1993-11-22 1995-06-13 Onyx Pharmaceuticals P53-binding polypeptides and polynucleotides encoding same
US5659024A (en) * 1994-01-14 1997-08-19 The Burnham Institute Promotors that regulate the expression of genes involved in cell death
NZ295371A (en) * 1994-10-28 1998-11-25 Max Planck Gesellschaft Protein kinase npk-10, a composition for treating alzheimers disease and cancer and diagnostic kits
US6218162B1 (en) * 1995-09-27 2001-04-17 Gerald Krystal SH2-containing inositol-phosphatase
US5863729A (en) 1996-07-09 1999-01-26 Washington University DNA sequences encoding human TcAK1 kinase
CA2212786A1 (en) 1996-08-13 1998-02-13 Takeda Chemical Industries, Ltd. Novel glutamine:fructose-6-phosphate amidotransferase, its production and use
US5962303A (en) * 1996-10-15 1999-10-05 Smithkline Beecham Corporation Topoisomerase III
SE9604731D0 (sv) * 1996-12-20 1996-12-20 Tamas Bartfai Konsulting Ab A component of intercellular junctions in the endothelium
JPH10257896A (ja) * 1997-01-17 1998-09-29 Seikagaku Kogyo Co Ltd グリコサミノグリカン硫酸基転移酵素のポリペプチド及びそれをコードするｄｎａ
CA2203083A1 (en) * 1997-04-18 1998-10-18 Gail Ouellette Gene and cdna involved in alzheimer's disease
US5955338A (en) * 1997-06-27 1999-09-21 Incyte Pharmaceuticals, Inc. Phosphatidylinositol 4,5-bisphosphate 5-phosphatase
AU8382998A (en) * 1997-07-02 1999-01-25 Genzyme Corporation P53 influenced gene expression
US6133246A (en) * 1997-08-13 2000-10-17 Isis Pharmaceuticals Inc. Antisense oligonucleotide compositions and methods for the modulation of JNK proteins
US5977311A (en) * 1997-09-23 1999-11-02 Curagen Corporation 53BP2 complexes
US6203788B1 (en) * 1997-09-29 2001-03-20 Adherex Inc. Compounds and methods for regulating cell adhesion
AUPO957397A0 (en) * 1997-10-01 1997-10-30 St. Vincent's Institute Of Medical Research Transporter protein
AU3908299A (en) * 1997-12-08 1999-06-28 Ontogeny, Inc. Cadherin-like polypeptides, methods and compositions related thereto
US6818744B1 (en) * 1997-12-15 2004-11-16 Raymond Frade p53 regulatory protein called RB18A and uses thereof
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US5942398A (en) * 1998-02-26 1999-08-24 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding glutx and uses thereof
US6214821B1 (en) * 1998-03-05 2001-04-10 Washington State University Research Foundation Methods and composition for the inhibition of cancer cells
US6020135A (en) * 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
US6165461A (en) * 1998-04-14 2000-12-26 Board Of Regents, University Of Texas System Tao protein kinases and methods of use therefor
EP1098968A4 (de) * 1998-07-20 2002-01-02 Univ Jefferson Homologe von nitrilase
AU5683099A (en) 1998-08-18 2000-03-14 Uab Research Foundation, The Blockade of glucose toxicity to the beta cells in the islets of langerhans
AU1736600A (en) * 1998-11-23 2000-06-13 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The P53 and vegf regulate tumor growth of nos2 expressing cancer cells
AU2216300A (en) 1998-12-22 2000-07-12 G.D. Searle & Co. Glutamine: fructose-6-phosphate aminotransferase ii enzyme and their encoding nucleic acids
US6762291B1 (en) 1999-03-16 2004-07-13 Exelixis, Inc. Insect p53 tumor suppressor genes and proteins
AU4352000A (en) * 1999-04-14 2000-11-14 Arbor Vita Corporation Clasp-2 transmembrane proteins
CA2383244A1 (en) * 1999-05-28 2000-12-07 Sugen, Inc. Protein kinases
US6558903B1 (en) * 1999-06-30 2003-05-06 Millennium Pharmaceuticals, Inc. Kinases and uses thereof
AU6091900A (en) * 1999-07-13 2001-01-30 Incyte Genomics, Inc. Human lim domain proteins
AU5840300A (en) * 1999-07-14 2001-01-30 University Of Lausanne Glutx polypeptide family and nucleic acids encoding same
WO2001009315A1 (en) * 1999-07-29 2001-02-08 Helix Research Institute Novel gene participating in the maintenance of smooth muscle cell differentiation
ES2592507T3 (es) * 1999-09-03 2016-11-30 The Brigham And Women's Hospital, Inc. Métodos y composiciones para el tratamiento de enfermedad inflamatoria mediante el uso de agentes moduladores de cadherina-11
JP2003527831A (ja) * 1999-10-05 2003-09-24 キュラジェン コーポレイション エンドゼピン様ポリペプチドおよびエンドゼピン様ポリペプチドをコードするポリヌクレオチド
WO2001029058A1 (en) 1999-10-15 2001-04-26 University Of Massachusetts Rna interference pathway genes as tools for targeted genetic interference
WO2001030964A2 (en) * 1999-10-22 2001-05-03 Lifespan Biosciences, Inc. Anti-cancer nucleic acid and protein targets
WO2001032928A2 (en) * 1999-11-05 2001-05-10 Phase-1 Molecular Toxicology Methods of determining individual hypersensitivity to an agent
CN1390255A (zh) 1999-11-24 2003-01-08 武田药品工业株式会社 与疾病相关的基因用途
EP1240194A2 (de) * 1999-11-24 2002-09-18 Sugen, Inc. Protein kinasen und protein kinase-ahnliche enzyme identifiziert durch genomisches sequenzieren
US6635742B1 (en) * 2000-01-25 2003-10-21 Nuvelo, Inc. Antibodies specific for semaphorin-like polypeptides
JP2004500814A (ja) * 1999-12-23 2004-01-15 インサイト・ゲノミックス・インコーポレイテッド 輸送体及びイオンチャネル
AU2001234944A1 (en) 2000-02-03 2001-08-14 Hyseq, Inc. Novel nucleic acids and polypeptides
JP2004502404A (ja) * 2000-02-17 2004-01-29 インサイト・ゲノミックス・インコーポレイテッド ヒトキナーゼ
WO2001062206A2 (en) * 2000-02-22 2001-08-30 Mount Sinai School Of Medicine Of New York University N-cadherin modulated migration, invasion, and metastasis
US6420382B2 (en) * 2000-02-25 2002-07-16 Merck & Co., Inc. Tyrosine kinase inhibitors
US7001735B2 (en) * 2000-03-01 2006-02-21 Albert Einstein College Of Medicine Of Yeshiva University Glucose transporter/sensor protein and uses thereof
US20030165831A1 (en) * 2000-03-21 2003-09-04 John Lee Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer
WO2001087918A1 (en) * 2000-05-16 2001-11-22 The Regents Of The University Of California Methods for identifying novel therapeutics and diagnostics in the p53 pathway
DE10024171A1 (de) * 2000-05-17 2001-12-20 Basf Lynx Bioscience Ag Neuronale Serin-Threonin-Protein-Kinase
EP1307545A2 (de) * 2000-05-26 2003-05-07 Bayer Aktiengesellschaft Regulation der menschlichen p78-ähnlichen serin-threonin kinase
EP1290187A2 (de) 2000-06-15 2003-03-12 Incyte Genomics, Inc. Humane kinasen
AU2001279106A1 (en) * 2000-07-28 2002-02-13 Chiron Corporation Isolation of drosophila and human polynucleotides encoding par-1 kinase, polypeptides encoded by the polynucleotides and methods utilizing the polynucleotides and polypeptides
WO2002033097A2 (en) * 2000-10-16 2002-04-25 Bayer Aktiengesellschaft Regulation of human sulfotransferase
WO2002036755A2 (en) * 2000-10-30 2002-05-10 Bayer Aktiengesellschaft Regulation of human inositolpolyphosphate 5-phosphatase
WO2002090378A2 (en) * 2001-05-09 2002-11-14 Genaissance Pharmaceuticals, Inc. Haplotypes of the ces2 gene
JP2005522982A (ja) * 2001-05-31 2005-08-04 カイロン コーポレイション 癌治療のための標的としてのｐ−カドヘリン
WO2003033708A2 (en) * 2001-10-15 2003-04-24 Bayer Healthcare Ag Regulation of human serine/threonine protein kinase
WO2003054190A1 (fr) * 2001-12-21 2003-07-03 Takeda Chemical Industries, Ltd. Nouvelles proteines et adn correspondants
AU2003224811A1 (en) * 2002-03-28 2003-10-13 Incyte Corporation Transporters and ion channels

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