ATE469175T1 - Prkcs als modifikatoren des beta catenin pfads und anwendungsverfahren - Google Patents

Prkcs als modifikatoren des beta catenin pfads und anwendungsverfahren

Info

Publication number
ATE469175T1
ATE469175T1 AT04781103T AT04781103T ATE469175T1 AT E469175 T1 ATE469175 T1 AT E469175T1 AT 04781103 T AT04781103 T AT 04781103T AT 04781103 T AT04781103 T AT 04781103T AT E469175 T1 ATE469175 T1 AT E469175T1
Authority
AT
Austria
Prior art keywords
beta catenin
prkcs
modifiers
application method
catenin pathway
Prior art date
Application number
AT04781103T
Other languages
English (en)
Inventor
Helen Francis-Lang
Christopher G Winter
Richard Benn Abegania Ventura
Timothy S Heuer
Joanne I Adamkewicz
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Application granted granted Critical
Publication of ATE469175T1 publication Critical patent/ATE469175T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
AT04781103T 2003-08-14 2004-08-13 Prkcs als modifikatoren des beta catenin pfads und anwendungsverfahren ATE469175T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49517203P 2003-08-14 2003-08-14
PCT/US2004/026361 WO2005016282A2 (en) 2003-08-14 2004-08-13 Prkcs as modifiers of the beta catenin pathway and methods of use

Publications (1)

Publication Number Publication Date
ATE469175T1 true ATE469175T1 (de) 2010-06-15

Family

ID=34193286

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04781084T ATE482979T1 (de) 2003-08-14 2004-08-12 Ups als den beta-catenin-pfad modifizierende substanzen und anwendungsverfahren
AT04781103T ATE469175T1 (de) 2003-08-14 2004-08-13 Prkcs als modifikatoren des beta catenin pfads und anwendungsverfahren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT04781084T ATE482979T1 (de) 2003-08-14 2004-08-12 Ups als den beta-catenin-pfad modifizierende substanzen und anwendungsverfahren

Country Status (8)

Country Link
US (2) US20080050313A1 (de)
EP (3) EP1651674B1 (de)
JP (3) JP2007502118A (de)
AT (2) ATE482979T1 (de)
AU (3) AU2004265662B2 (de)
CA (3) CA2535897A1 (de)
DE (2) DE602004029368D1 (de)
WO (3) WO2005017119A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4606712B2 (ja) 2003-01-08 2011-01-05 マサチューセッツ インスティテュート オブ テクノロジー 2−oスルファターゼ組成物および関連の方法
CA2674493C (en) 2007-01-05 2017-05-09 Massachusetts Institute Of Technology Compositions of and methods of using sulfatases from flavobacterium heparinum

Family Cites Families (27)

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NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4870009A (en) 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
US4670388A (en) 1982-12-30 1987-06-02 Carnegie Institution Of Washington Method of incorporating DNA into genome of drosophila
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
GB9517780D0 (en) 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
GB9517779D0 (en) 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
WO1998042876A1 (en) 1997-03-26 1998-10-01 Board Of Regents, The University Of Texas System Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US6066500A (en) * 1999-06-25 2000-05-23 Isis Pharmaceuticals Inc. Antisense modulation of Beta catenin expression
AU1086501A (en) 1999-10-15 2001-04-30 Carnegie Institution Of Washington Rna interference pathway genes as tools for targeted genetic interference
AU2001236990A1 (en) * 2000-02-14 2001-08-27 Yale University Compositions, methods and kits relating to uridine phosphorylase gene mutations
WO2001094629A2 (en) * 2000-06-05 2001-12-13 Avalon Pharmaceuticals Cancer gene determination and therapeutic screening using signature gene sets
US20020015943A1 (en) * 2000-07-31 2002-02-07 Mariann Bienz Assays, methods and means relating to the modulation of levels of nuclear beta-catenin
US20020110841A1 (en) * 2000-12-22 2002-08-15 KUFE Donald W. Regulation of cell growth by MUC1
US20030087250A1 (en) * 2001-03-14 2003-05-08 Millennium Pharmaceuticals, Inc. Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
US7771931B2 (en) * 2001-09-06 2010-08-10 The General Hospital Corporation Methods for diagnosing and treating diseases and conditions associated with protein kinase Cλ
WO2003052068A2 (en) * 2001-12-13 2003-06-26 Exelixis, Inc. Mbcats as modifiers of the beta-catenin pathway and methods of use
US20040014049A1 (en) * 2002-07-19 2004-01-22 Isis Pharmaceuticals Inc. Antisense modulation of protein kinase C-iota expression

Also Published As

Publication number Publication date
EP1651674B1 (de) 2010-09-29
EP1654349A4 (de) 2008-08-20
AU2004265662B2 (en) 2010-12-16
DE602004027387D1 (de) 2010-07-08
AU2004264952B2 (en) 2010-12-16
EP1651674A2 (de) 2006-05-03
JP2007502119A (ja) 2007-02-08
EP1654349A2 (de) 2006-05-10
EP1653915B1 (de) 2010-05-26
AU2004265662A1 (en) 2005-02-24
WO2005017118A2 (en) 2005-02-24
ATE482979T1 (de) 2010-10-15
CA2535901A1 (en) 2005-02-24
DE602004029368D1 (de) 2010-11-11
JP2007502118A (ja) 2007-02-08
AU2004265661A1 (en) 2005-02-24
WO2005017119A3 (en) 2006-01-26
CA2535897A1 (en) 2005-02-24
WO2005017118A3 (en) 2006-07-06
EP1653915A2 (de) 2006-05-10
EP1651674A4 (de) 2006-09-20
AU2004264952A1 (en) 2005-02-24
US20070128606A1 (en) 2007-06-07
WO2005016282A3 (en) 2006-04-06
EP1653915A4 (de) 2007-09-05
WO2005017119A2 (en) 2005-02-24
CA2535812A1 (en) 2005-02-24
WO2005016282A2 (en) 2005-02-24
US20080050313A1 (en) 2008-02-28
JP2007515935A (ja) 2007-06-21

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