WO2004005483A3 - ADCY3S AS MODIFIERS OF THE p21 PATHWAY AND METHODS OF USE - Google Patents

ADCY3S AS MODIFIERS OF THE p21 PATHWAY AND METHODS OF USE Download PDF

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Publication number
WO2004005483A3
WO2004005483A3 PCT/US2003/021375 US0321375W WO2004005483A3 WO 2004005483 A3 WO2004005483 A3 WO 2004005483A3 US 0321375 W US0321375 W US 0321375W WO 2004005483 A3 WO2004005483 A3 WO 2004005483A3
Authority
WO
WIPO (PCT)
Prior art keywords
pathway
methods
adcy3s
modifiers
adcy3
Prior art date
Application number
PCT/US2003/021375
Other languages
French (fr)
Other versions
WO2004005483A2 (en
Inventor
Helen Francis-Lang
Lori Friedman
Thomas Kidd
Siobhan Roche
Haiguang Zhang
Original Assignee
Exelixis Inc
Helen Francis-Lang
Lori Friedman
Thomas Kidd
Siobhan Roche
Haiguang Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Helen Francis-Lang, Lori Friedman, Thomas Kidd, Siobhan Roche, Haiguang Zhang filed Critical Exelixis Inc
Priority to AU2003265263A priority Critical patent/AU2003265263A1/en
Publication of WO2004005483A2 publication Critical patent/WO2004005483A2/en
Publication of WO2004005483A3 publication Critical patent/WO2004005483A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Human ADCY3 genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of ADCY3 are provided.
PCT/US2003/021375 2002-07-10 2003-07-09 ADCY3S AS MODIFIERS OF THE p21 PATHWAY AND METHODS OF USE WO2004005483A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003265263A AU2003265263A1 (en) 2002-07-10 2003-07-09 ADCY3S AS MODIFIERS OF THE p21 PATHWAY AND METHODS OF USE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39479502P 2002-07-10 2002-07-10
US60/394,795 2002-07-10

Publications (2)

Publication Number Publication Date
WO2004005483A2 WO2004005483A2 (en) 2004-01-15
WO2004005483A3 true WO2004005483A3 (en) 2005-12-22

Family

ID=30115769

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/021375 WO2004005483A2 (en) 2002-07-10 2003-07-09 ADCY3S AS MODIFIERS OF THE p21 PATHWAY AND METHODS OF USE

Country Status (2)

Country Link
AU (1) AU2003265263A1 (en)
WO (1) WO2004005483A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005100998A2 (en) * 2004-04-16 2005-10-27 Europroteome Ag Membrane markers for use in cancer diagnosis and therapy
KR101416147B1 (en) * 2012-07-18 2014-07-09 국립암센터 Use of ADCY3 for the Diagnosis and Treatment of Gastric Cancer
EP2775304A1 (en) * 2013-03-07 2014-09-10 Universitätsspital Basel Methods for detecting inflammatory disorder

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SINNARAJAH S. ET AL: "RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III.", NATURE., vol. 409, 22 February 2001 (2001-02-22), pages 1051 - 1055, XP002992247 *
WONG S.T. ET AL: "Disruption of the Type III Adenylyl Cyclase Gene Leads to Peripheral and Behavioral Anosmia in Transgenic Mice.", NEURON., vol. 27, no. 3, September 2000 (2000-09-01), pages 487 - 497, XP002992246 *

Also Published As

Publication number Publication date
WO2004005483A2 (en) 2004-01-15
AU2003265263A1 (en) 2004-01-23

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