WO2005001026A3 - Adks as modifiers of the pten pathway and methods of use - Google Patents

Adks as modifiers of the pten pathway and methods of use Download PDF

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Publication number
WO2005001026A3
WO2005001026A3 PCT/US2004/014963 US2004014963W WO2005001026A3 WO 2005001026 A3 WO2005001026 A3 WO 2005001026A3 US 2004014963 W US2004014963 W US 2004014963W WO 2005001026 A3 WO2005001026 A3 WO 2005001026A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
adks
modifiers
pten
pten pathway
Prior art date
Application number
PCT/US2004/014963
Other languages
French (fr)
Other versions
WO2005001026A2 (en
Inventor
Michael R Costa
Garth Joseph Mcgrath
Kim Lickteig
Original Assignee
Exelixis Inc
Michael R Costa
Garth Joseph Mcgrath
Kim Lickteig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Michael R Costa, Garth Joseph Mcgrath, Kim Lickteig filed Critical Exelixis Inc
Publication of WO2005001026A2 publication Critical patent/WO2005001026A2/en
Publication of WO2005001026A3 publication Critical patent/WO2005001026A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2510/00—Detection of programmed cell death, i.e. apoptosis

Abstract

Human ADK genes are identified as modulators of the PTEN pathway, and thus are therapeutic targets for disorders associated with defective PTEN function. Methods for identifying modulators of PTEN, comprising screening for agents that modulate the activity of ADK are provided.
PCT/US2004/014963 2003-05-14 2004-05-13 Adks as modifiers of the pten pathway and methods of use WO2005001026A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47074603P 2003-05-14 2003-05-14
US60/470,746 2003-05-14

Publications (2)

Publication Number Publication Date
WO2005001026A2 WO2005001026A2 (en) 2005-01-06
WO2005001026A3 true WO2005001026A3 (en) 2005-03-24

Family

ID=33551422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/014963 WO2005001026A2 (en) 2003-05-14 2004-05-13 Adks as modifiers of the pten pathway and methods of use

Country Status (1)

Country Link
WO (1) WO2005001026A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006099185A2 (en) * 2005-03-10 2006-09-21 Exelixis, Inc Brsk1s as modifiers of the pten/akt pathway and methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040005644A1 (en) * 2002-02-28 2004-01-08 Su Yan A. Method and composition for detection and treatment of breast cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040005644A1 (en) * 2002-02-28 2004-01-08 Su Yan A. Method and composition for detection and treatment of breast cancer

Also Published As

Publication number Publication date
WO2005001026A2 (en) 2005-01-06

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