DE69609188T2 - Neutralisierende monoklonale antikörper gegen respiratorischen synzytialvirus - Google Patents
Neutralisierende monoklonale antikörper gegen respiratorischen synzytialvirusInfo
- Publication number
- DE69609188T2 DE69609188T2 DE69609188T DE69609188T DE69609188T2 DE 69609188 T2 DE69609188 T2 DE 69609188T2 DE 69609188 T DE69609188 T DE 69609188T DE 69609188 T DE69609188 T DE 69609188T DE 69609188 T2 DE69609188 T2 DE 69609188T2
- Authority
- DE
- Germany
- Prior art keywords
- antibodies
- respiratory syncytial
- syncytial virus
- monoclonal antibodies
- antibodies against
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000725643 Respiratory syncytial virus Species 0.000 title abstract 2
- 230000003472 neutralizing effect Effects 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 238000010367 cloning Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1006—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being against or targeting material from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US393195P | 1995-09-18 | 1995-09-18 | |
PCT/US1996/014937 WO1997010846A1 (en) | 1995-09-18 | 1996-09-18 | Neutralizing monoclonal antibodies to respiratory syncytial virus |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69609188D1 DE69609188D1 (de) | 2000-08-10 |
DE69609188T2 true DE69609188T2 (de) | 2000-12-21 |
Family
ID=21708285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69609188T Expired - Fee Related DE69609188T2 (de) | 1995-09-18 | 1996-09-18 | Neutralisierende monoklonale antikörper gegen respiratorischen synzytialvirus |
Country Status (11)
Country | Link |
---|---|
US (3) | US7488477B2 (de) |
EP (2) | EP0851924A1 (de) |
AT (1) | ATE194291T1 (de) |
AU (2) | AU7075496A (de) |
CA (2) | CA2230116A1 (de) |
DE (1) | DE69609188T2 (de) |
DK (1) | DK0853487T3 (de) |
ES (1) | ES2148799T3 (de) |
GR (1) | GR3034349T3 (de) |
PT (1) | PT853487E (de) |
WO (2) | WO1997010846A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7229619B1 (en) | 2000-11-28 | 2007-06-12 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
WO2001055217A1 (en) * | 2000-01-27 | 2001-08-02 | Medimmune, Inc. | Ultra high affinity neutralizing antibodies |
JP2003525061A (ja) * | 2000-03-01 | 2003-08-26 | メディミューン,インコーポレイテッド | 高効力組換え抗体およびその産生法 |
US7179900B2 (en) * | 2000-11-28 | 2007-02-20 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
US7425618B2 (en) * | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
EP1900753B1 (de) | 2002-11-08 | 2017-08-09 | Ablynx N.V. | Verfahren zur Verabreichung therapeutischer Polypeptide und Polypeptide dafür |
US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
US20060034845A1 (en) | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
GB2398783A (en) * | 2003-02-26 | 2004-09-01 | Antonio Lanzavecchia | A method for producing immortalised human B memory lymphocytes |
GB0306618D0 (en) * | 2003-03-22 | 2003-04-30 | Univ Newcastle | Antibody |
CN101065151B (zh) * | 2004-09-23 | 2014-12-10 | 健泰科生物技术公司 | 半胱氨酸改造的抗体和偶联物 |
US20100111856A1 (en) * | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
JP2008518936A (ja) * | 2004-10-29 | 2008-06-05 | メディミューン,インコーポレーテッド | Rsv感染症および関連状態を予防および治療する方法 |
CN101679513A (zh) | 2007-03-06 | 2010-03-24 | 西福根有限公司 | 用于治疗呼吸道合胞病毒感染的重组抗体 |
EP1997830A1 (de) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV-spezifische Bindemoleküle und Mittel zu ihrer Herstellung |
AU2008304574A1 (en) * | 2007-09-24 | 2009-04-02 | Vanderbilt University | Monoclonal antibodies to respiratory syncytial virus and uses thereof |
RU2505544C2 (ru) * | 2007-10-19 | 2014-01-27 | Дженентек, Инк. | Антитела против tenb2, сконструированные с цистеином, и конъюгаты антитело - лекарственное средство |
KR100938998B1 (ko) * | 2008-01-08 | 2010-01-28 | (주) 에이프로젠 | 호흡기 신시티움 바이러스에 대한 항체 |
US8591961B2 (en) | 2008-09-04 | 2013-11-26 | Allergan, Inc. | Aesthetic treatment of scars and aging skin |
JP5762408B2 (ja) | 2009-08-13 | 2015-08-12 | クルセル ホランド ベー ヴェー | ヒト呼吸器合胞体ウイルス(rsv)に対する抗体および使用方法 |
US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
KR101839163B1 (ko) | 2010-06-08 | 2018-03-15 | 제넨테크, 인크. | 시스테인 조작된 항체 및 접합체 |
CN103097412B (zh) | 2010-07-09 | 2016-08-10 | 克鲁塞尔荷兰公司 | 抗人呼吸道合胞病毒(rsv)抗体以及使用方法 |
TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒f蛋白質的人類抗體及其使用方法 |
EP3191521A2 (de) | 2014-09-12 | 2017-07-19 | F. Hoffmann-La Roche AG | Cystein-manipulierte antikörper und konjugate |
JO3555B1 (ar) | 2015-10-29 | 2020-07-05 | Merck Sharp & Dohme | جسم مضاد يبطل فعالية فيروس الالتهاب الرئوي البشري |
EA039222B1 (ru) * | 2016-07-27 | 2021-12-20 | Мерк Шарп И Доум Корп. | Антитело, нейтрализующее респираторно-синцитиальный вирус человека |
EP3525820A4 (de) * | 2016-10-17 | 2020-09-16 | Vanderbilt University | Humane respiratorische synzytial-virus-antikörper und verfahren zur verwendung davon |
US11312761B2 (en) | 2016-10-21 | 2022-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
WO2018075954A2 (en) | 2016-10-21 | 2018-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
WO2018075974A2 (en) | 2016-10-21 | 2018-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
TW202228779A (zh) | 2017-03-01 | 2022-08-01 | 英商梅迪繆思有限公司 | 抗rsv單株抗體配製物 |
US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
SG11201909955XA (en) | 2017-05-02 | 2019-11-28 | Merck Sharp & Dohme | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies |
SG11202007241WA (en) * | 2018-01-31 | 2020-08-28 | Wistar Inst | Nucleic acid antibody constructs for use against respiratory syncytial virus |
WO2021202463A1 (en) | 2020-03-30 | 2021-10-07 | Danisco Us Inc | Anti-rsv antibodies |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US4800078A (en) * | 1987-05-28 | 1989-01-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Immunotherapeutic method of treating respiratory disease by intranasal administration of Igb |
GB9019812D0 (en) * | 1990-09-11 | 1990-10-24 | Scotgen Ltd | Novel antibodies for treatment and prevention of infection in animals and man |
GB9207479D0 (en) * | 1992-04-06 | 1992-05-20 | Scotgen Ltd | Novel antibodies for treatment and prevention of respiratory syncytial virus infection in animals and man |
CA2144043C (en) * | 1992-09-16 | 2005-01-18 | Dennis R. Burton | Human neutralizing monoclonal antibodies to respiratory syncytial virus |
AU3660893A (en) * | 1993-01-29 | 1994-08-15 | Med Immune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
CA2168349A1 (en) * | 1993-07-30 | 1995-02-09 | Lingxun Duan | Intracellular immunization |
AU689489B2 (en) * | 1993-07-30 | 1998-04-02 | Oravax, Inc | Monoclonal IgA antibody against respiratory syncytial virus |
-
1996
- 1996-09-18 AU AU70754/96A patent/AU7075496A/en not_active Abandoned
- 1996-09-18 ES ES96933810T patent/ES2148799T3/es not_active Expired - Lifetime
- 1996-09-18 WO PCT/US1996/014937 patent/WO1997010846A1/en active IP Right Grant
- 1996-09-18 DK DK96933810T patent/DK0853487T3/da active
- 1996-09-18 EP EP96931633A patent/EP0851924A1/de not_active Withdrawn
- 1996-09-18 EP EP96933810A patent/EP0853487B1/de not_active Expired - Lifetime
- 1996-09-18 PT PT96933810T patent/PT853487E/pt unknown
- 1996-09-18 WO PCT/US1996/014944 patent/WO1997011177A1/en not_active Application Discontinuation
- 1996-09-18 CA CA002230116A patent/CA2230116A1/en not_active Abandoned
- 1996-09-18 AT AT96933810T patent/ATE194291T1/de active
- 1996-09-18 AU AU72400/96A patent/AU7240096A/en not_active Abandoned
- 1996-09-18 DE DE69609188T patent/DE69609188T2/de not_active Expired - Fee Related
- 1996-09-18 CA CA002230127A patent/CA2230127A1/en not_active Abandoned
-
2000
- 2000-09-06 GR GR20000402037T patent/GR3034349T3/el not_active IP Right Cessation
-
2003
- 2003-04-30 US US10/425,855 patent/US7488477B2/en not_active Expired - Fee Related
-
2008
- 2008-04-24 US US12/082,000 patent/US20090110684A1/en not_active Abandoned
-
2011
- 2011-09-30 US US13/250,357 patent/US8221759B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2230127A1 (en) | 1997-03-27 |
WO1997010846A1 (en) | 1997-03-27 |
US20120087909A1 (en) | 2012-04-12 |
US7488477B2 (en) | 2009-02-10 |
DK0853487T3 (da) | 2000-10-23 |
GR3034349T3 (en) | 2000-12-29 |
US20090110684A1 (en) | 2009-04-30 |
ES2148799T3 (es) | 2000-10-16 |
DE69609188D1 (de) | 2000-08-10 |
CA2230116A1 (en) | 1997-03-27 |
EP0851924A1 (de) | 1998-07-08 |
WO1997011177A1 (en) | 1997-03-27 |
AU7240096A (en) | 1997-04-09 |
AU7075496A (en) | 1997-04-09 |
US8221759B2 (en) | 2012-07-17 |
US20040005324A1 (en) | 2004-01-08 |
ATE194291T1 (de) | 2000-07-15 |
EP0853487B1 (de) | 2000-07-05 |
PT853487E (pt) | 2000-11-30 |
EP0853487A1 (de) | 1998-07-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |