MA39095A1 - Anticorps et immunoconjugués anti-cd33 - Google Patents
Anticorps et immunoconjugués anti-cd33Info
- Publication number
- MA39095A1 MA39095A1 MA39095A MA39095A MA39095A1 MA 39095 A1 MA39095 A1 MA 39095A1 MA 39095 A MA39095 A MA 39095A MA 39095 A MA39095 A MA 39095A MA 39095 A1 MA39095 A1 MA 39095A1
- Authority
- MA
- Morocco
- Prior art keywords
- immunoconjugates
- antibodies
- methods
- well
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
Abstract
L'invention concerne des anticorps et des immunoconjugués anti-cd33 ainsi que des procédés d'utilisation de ceux-ci.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361916087P | 2013-12-13 | 2013-12-13 | |
PCT/US2014/069874 WO2015089344A1 (fr) | 2013-12-13 | 2014-12-12 | Anticorps et immunoconjugués anti-cd33 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA39095A1 true MA39095A1 (fr) | 2018-08-31 |
Family
ID=52282942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA39095A MA39095A1 (fr) | 2013-12-13 | 2014-12-12 | Anticorps et immunoconjugués anti-cd33 |
Country Status (20)
Country | Link |
---|---|
US (2) | US9951133B2 (fr) |
EP (2) | EP3080164B1 (fr) |
JP (3) | JP6502942B2 (fr) |
KR (1) | KR20160098328A (fr) |
CN (2) | CN110590950A (fr) |
AR (1) | AR098743A1 (fr) |
AU (1) | AU2014362238A1 (fr) |
CA (1) | CA2931340A1 (fr) |
CL (1) | CL2016001477A1 (fr) |
CR (1) | CR20160257A (fr) |
EA (1) | EA201691214A1 (fr) |
IL (1) | IL245757A0 (fr) |
MA (1) | MA39095A1 (fr) |
MX (1) | MX2016007576A (fr) |
PE (1) | PE20160712A1 (fr) |
PH (1) | PH12016501143A1 (fr) |
SG (1) | SG11201604784XA (fr) |
TW (1) | TW201533060A (fr) |
WO (1) | WO2015089344A1 (fr) |
ZA (1) | ZA201603548B (fr) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2881966C (fr) | 2012-08-24 | 2020-10-06 | The Regents Of The University Of California | Anticorps et vaccins utilisables en vue du traitement de cancers ror1 et de l'inhibition de la metastase |
GB201510010D0 (en) | 2015-06-09 | 2015-07-22 | King S College London | PDD and BPD compounds |
US11136390B2 (en) | 2015-06-12 | 2021-10-05 | Alector Llc | Anti-CD33 antibodies and methods of use thereof |
JP2018518491A (ja) | 2015-06-12 | 2018-07-12 | アレクトル エルエルシー | 抗cd33抗体及びその使用方法 |
US20180339985A1 (en) | 2015-08-21 | 2018-11-29 | Femtogenix Limited | Pdd compounds |
GB201514928D0 (en) | 2015-08-21 | 2015-10-07 | King S College London | PDD compounds |
US20190203299A1 (en) * | 2016-04-06 | 2019-07-04 | University Of Florida Research Foundation, Incorporated | Biomarkers for anti-leukemic therapy |
EP3452088A4 (fr) * | 2016-05-03 | 2020-04-15 | The Scripps Research Institute | Anticorps agonistes de trkb pour le traitement de troubles neurodégénératifs |
JP6738909B2 (ja) * | 2016-05-27 | 2020-08-12 | アクティニウム ファーマシューティカルズ インコーポレイテッド | 血液悪性疾患を処置するための低用量抗体に基づく方法 |
CA3029003A1 (fr) | 2016-06-27 | 2018-01-04 | The Regents Of The University Of California | Associations medicamenteuses pour le traitement du cancer |
US11261250B2 (en) | 2016-07-22 | 2022-03-01 | Fred Hutchinson Cancer Research Center | Bi-specific molecule for cell-specific Notch inhibition and related methods and compositions |
CN109689111B (zh) * | 2016-08-11 | 2024-04-05 | 基因泰克公司 | 吡咯并苯并二氮杂䓬前药及其抗体缀合物 |
WO2018102682A1 (fr) | 2016-12-01 | 2018-06-07 | Regeneron Pharmaceuticals, Inc. | Anticorps anti-pd-l1 radiomarqués pour imagerie immuno-pet |
JP2020506971A (ja) | 2017-02-08 | 2020-03-05 | ドラゴンフライ セラピューティクス, インコーポレイテッド | ナチュラルキラー細胞の活性化のための多重特異性結合タンパク質およびがんを処置するためのその治療的使用 |
JP7167041B2 (ja) | 2017-02-10 | 2022-11-08 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 免疫petイメージングのための放射標識抗lag3抗体 |
CN110944661A (zh) | 2017-02-20 | 2020-03-31 | 蜻蜓疗法股份有限公司 | 结合her2、nkg2d和cd16的蛋白质 |
US20200148767A1 (en) * | 2017-05-26 | 2020-05-14 | Fred Hutchinson Cancer Research Center | Anti-cd33 antibodies and uses thereof |
WO2019006280A1 (fr) * | 2017-06-30 | 2019-01-03 | Lentigen Technology, Inc. | Anticorps monoclonaux humains spécifiques de cd33 et leurs procédés d'utilisation |
US10730944B2 (en) | 2017-07-24 | 2020-08-04 | Regeneron Pharmaceuticals, Inc. | Anti-CD8 antibodies and uses thereof |
CN110662765B (zh) | 2017-08-03 | 2023-09-29 | 艾利妥 | 抗cd33抗体及其使用方法 |
JP2021512630A (ja) | 2018-02-08 | 2021-05-20 | ドラゴンフライ セラピューティクス, インコーポレイテッド | Nkg2d受容体を標的とする抗体可変ドメイン |
MX2020008683A (es) * | 2018-02-20 | 2020-12-07 | Dragonfly Therapeutics Inc | Dominios variables de anticuerpo que se dirigen a cd33 y sus usos. |
JOP20190116A1 (ar) | 2018-05-24 | 2019-11-24 | Janssen Biotech Inc | الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها |
WO2020068058A1 (fr) * | 2018-09-25 | 2020-04-02 | Academia Sinica | Anticorps anti-siglec, composition pharmaceutique le comprenant, et leurs utilisations |
US11666672B2 (en) * | 2018-11-21 | 2023-06-06 | City Of Hope | Anti-CD33 antibody-guided imaging and treatment of acute myeloid leukemia |
AU2020268827A1 (en) * | 2019-05-04 | 2021-11-11 | Inhibrx, Inc. | CD33-binding polypeptides and uses thereof |
EP4011863A4 (fr) | 2019-08-08 | 2023-09-20 | Toagosei Co., Ltd. | Composé 2-cyanoacrylate et composition adhésive |
WO2021078123A1 (fr) * | 2019-10-21 | 2021-04-29 | Nanjing Leads Biolabs Co., Ltd. | PROTÉINE RECOMBINANTE CIBLANT PD-1 ET TGFβ |
WO2021138407A2 (fr) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Molécules multifonctionnelles se liant à cd33 et utilisations associées |
US20230365676A1 (en) * | 2020-09-15 | 2023-11-16 | University Of Florida Research Foundation, Incorporated | Cd33 antibodies |
JP2024504728A (ja) | 2021-01-26 | 2024-02-01 | サイトケアズ (シャンハイ) インコーポレイテッド | キメラ抗原受容体(car)構築物およびcar構築物を発現するnk細胞 |
CN112940132B (zh) * | 2021-03-22 | 2022-04-01 | 深圳市亚辉龙生物科技股份有限公司 | Chi3l1抗体及其应用、核酸、重组表达载体系统和宿主细胞 |
CN113667114B (zh) * | 2021-08-02 | 2023-07-14 | 北京大学深圳医院 | 一种主链可消除的so2纳米前药的制备方法及其用途 |
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2014
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- 2014-12-12 CA CA2931340A patent/CA2931340A1/fr not_active Abandoned
- 2014-12-12 KR KR1020167018377A patent/KR20160098328A/ko not_active Application Discontinuation
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- 2014-12-12 WO PCT/US2014/069874 patent/WO2015089344A1/fr active Application Filing
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2018
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Also Published As
Publication number | Publication date |
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JP2017505604A (ja) | 2017-02-23 |
EA201691214A1 (ru) | 2016-12-30 |
US20170002074A1 (en) | 2017-01-05 |
ZA201603548B (en) | 2018-11-28 |
PE20160712A1 (es) | 2016-07-26 |
EP3080164A1 (fr) | 2016-10-19 |
EP3461845B1 (fr) | 2020-09-16 |
AR098743A1 (es) | 2016-06-08 |
US10556951B2 (en) | 2020-02-11 |
CN105814084B (zh) | 2019-09-24 |
MX2016007576A (es) | 2016-10-03 |
CL2016001477A1 (es) | 2017-01-20 |
IL245757A0 (en) | 2016-07-31 |
KR20160098328A (ko) | 2016-08-18 |
EP3461845A1 (fr) | 2019-04-03 |
WO2015089344A9 (fr) | 2016-01-14 |
SG11201604784XA (en) | 2016-07-28 |
JP2021104019A (ja) | 2021-07-26 |
EP3080164B1 (fr) | 2019-01-16 |
AU2014362238A1 (en) | 2016-06-09 |
TW201533060A (zh) | 2015-09-01 |
US20180312586A1 (en) | 2018-11-01 |
CN105814084A (zh) | 2016-07-27 |
CA2931340A1 (fr) | 2015-06-18 |
JP6502942B2 (ja) | 2019-04-17 |
JP2019146572A (ja) | 2019-09-05 |
US9951133B2 (en) | 2018-04-24 |
CN110590950A (zh) | 2019-12-20 |
EP3461845A8 (fr) | 2019-05-29 |
CR20160257A (es) | 2016-07-22 |
WO2015089344A1 (fr) | 2015-06-18 |
PH12016501143A1 (en) | 2016-08-15 |
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