MA35898B1 - Anticorps anti-lrp5 et leurs procédés d'utilisation - Google Patents

Anticorps anti-lrp5 et leurs procédés d'utilisation

Info

Publication number
MA35898B1
MA35898B1 MA37268A MA37268A MA35898B1 MA 35898 B1 MA35898 B1 MA 35898B1 MA 37268 A MA37268 A MA 37268A MA 37268 A MA37268 A MA 37268A MA 35898 B1 MA35898 B1 MA 35898B1
Authority
MA
Morocco
Prior art keywords
methods
lrp5 antibodies
lrp5
antibodies
making
Prior art date
Application number
MA37268A
Other languages
English (en)
Inventor
Yan Wu
Weilan Ye
Jeremy Bryant Burton
Cecilia Chiu
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MA35898B1 publication Critical patent/MA35898B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des anticorps anti-lrp5 et des procédés de fabrication et d'utilisation associés.
MA37268A 2012-01-18 2014-08-06 Anticorps anti-lrp5 et leurs procédés d'utilisation MA35898B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261588100P 2012-01-18 2012-01-18
PCT/US2013/022045 WO2013109819A1 (fr) 2012-01-18 2013-01-18 Anticorps anti-lrp5 et leurs procédés d'utilisation

Publications (1)

Publication Number Publication Date
MA35898B1 true MA35898B1 (fr) 2014-12-01

Family

ID=47604271

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37268A MA35898B1 (fr) 2012-01-18 2014-08-06 Anticorps anti-lrp5 et leurs procédés d'utilisation

Country Status (24)

Country Link
US (4) US9200072B2 (fr)
EP (1) EP2804629A1 (fr)
JP (1) JP6242813B2 (fr)
KR (1) KR20140116490A (fr)
CN (1) CN104066449B (fr)
AR (1) AR089752A1 (fr)
AU (1) AU2013209707A1 (fr)
BR (1) BR112014017518A2 (fr)
CA (1) CA2862422A1 (fr)
CL (1) CL2014001888A1 (fr)
CO (1) CO7000747A2 (fr)
CR (1) CR20140382A (fr)
EA (1) EA028202B1 (fr)
IL (1) IL233317A0 (fr)
IN (1) IN2014DN05885A (fr)
MA (1) MA35898B1 (fr)
MX (1) MX2014008157A (fr)
NZ (1) NZ626520A (fr)
PE (1) PE20141561A1 (fr)
PH (1) PH12014501605A1 (fr)
SG (2) SG10201601747XA (fr)
TW (1) TW201335187A (fr)
WO (1) WO2013109819A1 (fr)
ZA (1) ZA201404675B (fr)

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MX2011002418A (es) * 2008-09-10 2011-04-05 Genentech Inc Metodos para inhibir la angiogenesis ocular.
JP5861469B2 (ja) * 2012-01-23 2016-02-16 日本電気硝子株式会社 ガラス管の清浄切断装置と清浄切断方法
BR112017000130A2 (pt) 2014-07-11 2018-01-09 Genentech Inc método para atenuar a toxicidade associada à inibição da via de notch e método de tratamento do câncer
US11142577B2 (en) 2014-09-12 2021-10-12 The Board Of Trustees Of The Leland Stanford Junior University WNT signaling agonist molecules
CA2999756A1 (fr) * 2015-09-24 2017-03-30 The University Of North Carolina At Chapel Hill Methodes et compositions pour reduire les metastases
CN106367517A (zh) * 2016-09-28 2017-02-01 湖北工业大学 一种低密度脂蛋白受体相关蛋白5基因突变检测的试剂及应用
JP2020518675A (ja) * 2017-05-05 2020-06-25 レチナール ソリューションズ エルエルシー ノリン誘発性の遺伝子発現および疾患を処置するためのその使用
EP3630816B1 (fr) * 2017-05-31 2024-03-20 Boehringer Ingelheim International GmbH Polypeptides antagonistes de la signalisation wnt dans des cellules tumorales
WO2019126398A1 (fr) * 2017-12-19 2019-06-27 Surrozen, Inc. Molécules de substitution de wnt et leurs utilisations
EP3728323A4 (fr) 2017-12-19 2022-01-26 Surrozen Operating, Inc. Anticorps anti-fzd et méthodes d'utilisation
AU2018393076B2 (en) 2017-12-19 2025-11-20 Surrozen Operating, Inc. Anti-LRP5/6 antibodies and methods of use
WO2019129677A1 (fr) * 2017-12-29 2019-07-04 F. Hoffmann-La Roche Ag Anticorps anti-vegf et procédés d'utilisation
CN119798435A (zh) * 2019-08-14 2025-04-11 安托拉诊疗公司 与lrp5蛋白结合的抗体及使用方法
US11834512B2 (en) 2020-05-04 2023-12-05 The Regents Of The University Of California Inhibiting anti-ENPP1 antibodies
CN111909935B (zh) * 2020-07-17 2022-11-15 武汉纽福斯生物科技有限公司 重组人卷曲蛋白受体4(fzd4)的表达载体及其应用
KR102536092B1 (ko) * 2020-09-29 2023-05-24 조선대학교산학협력단 Lrp5 발현 또는 활성 억제제를 포함하는 허혈성 심장질환의 예방 또는 치료용 약학적 조성물
IL303344A (en) 2020-12-18 2023-08-01 Antlera Therapeutics Inc Tetravalent FZD and WNT receptor binding antibody compounds
WO2023250402A2 (fr) * 2022-06-22 2023-12-28 Antlera Therapeutics Inc. Molécules d'anticorps de liaison au co-récepteur wnt et fzd tétravalent et leurs utilisations
WO2025149667A1 (fr) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Conjugués anticorps-médicament et leurs utilisations
CN118599000A (zh) * 2024-05-11 2024-09-06 中山大学附属第三医院 Lrp5作为靶向分子在治疗糖尿病肾病中的应用
US20260070966A1 (en) 2024-09-06 2026-03-12 Eyebiotech Limited Multivalent fzd4, wnt co-receptor, and vegf receptor molecules and uses thereof
WO2026055310A1 (fr) 2024-09-06 2026-03-12 Merck Sharp & Dohme Llc Molécules de liaison multivalentes au fzd4, au co-récepteur wnt et au vegf et leurs utilisations

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JP2015511119A (ja) 2015-04-16
PE20141561A1 (es) 2014-11-12
IL233317A0 (en) 2014-08-31
CA2862422A1 (fr) 2013-07-25
US10035854B2 (en) 2018-07-31
PH12014501605A1 (en) 2014-10-08
NZ626520A (en) 2016-09-30
IN2014DN05885A (fr) 2015-06-05
US9200072B2 (en) 2015-12-01
MX2014008157A (es) 2014-10-06
US9522954B2 (en) 2016-12-20
SG11201404198TA (en) 2014-08-28
EA201491357A1 (ru) 2014-11-28
ZA201404675B (en) 2016-11-30
EP2804629A1 (fr) 2014-11-26
CR20140382A (es) 2014-10-07
SG10201601747XA (en) 2016-04-28
CL2014001888A1 (es) 2014-10-03
BR112014017518A2 (pt) 2018-09-04
HK1197187A1 (en) 2015-01-09
EA028202B1 (ru) 2017-10-31
TW201335187A (zh) 2013-09-01
WO2013109819A1 (fr) 2013-07-25
KR20140116490A (ko) 2014-10-02
US20130183320A1 (en) 2013-07-18
CO7000747A2 (es) 2014-07-21
JP6242813B2 (ja) 2017-12-06
CN104066449B (zh) 2018-04-27
AU2013209707A1 (en) 2014-07-24
AR089752A1 (es) 2014-09-17
US20190010228A1 (en) 2019-01-10
US20170166636A1 (en) 2017-06-15
US20160185855A1 (en) 2016-06-30
BR112014017518A8 (pt) 2017-07-04

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