SI2235064T1 - Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov - Google Patents

Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov

Info

Publication number
SI2235064T1
SI2235064T1 SI200931342T SI200931342T SI2235064T1 SI 2235064 T1 SI2235064 T1 SI 2235064T1 SI 200931342 T SI200931342 T SI 200931342T SI 200931342 T SI200931342 T SI 200931342T SI 2235064 T1 SI2235064 T1 SI 2235064T1
Authority
SI
Slovenia
Prior art keywords
making antibody
electrostatic steering
steering effects
heterodimeric molecules
heterodimeric
Prior art date
Application number
SI200931342T
Other languages
English (en)
Inventor
Gunasekaran Kannan
Michael Wittekind
Wei Yan
Martin Pentony
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of SI2235064T1 publication Critical patent/SI2235064T1/sl

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/526CH3 domain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SI200931342T 2008-01-07 2009-01-06 Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov SI2235064T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1956908P 2008-01-07 2008-01-07
US12030508P 2008-12-05 2008-12-05
PCT/US2009/000071 WO2009089004A1 (en) 2008-01-07 2009-01-06 Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
EP09700643.1A EP2235064B1 (en) 2008-01-07 2009-01-06 Method for making antibody fc-heterodimeric molecules using electrostatic steering effects

Publications (1)

Publication Number Publication Date
SI2235064T1 true SI2235064T1 (sl) 2016-04-29

Family

ID=40578139

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200931342T SI2235064T1 (sl) 2008-01-07 2009-01-06 Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov

Country Status (14)

Country Link
US (2) US8592562B2 (sl)
EP (3) EP2235064B1 (sl)
JP (3) JP6157046B2 (sl)
AU (1) AU2009204501B2 (sl)
CA (1) CA2709847C (sl)
CY (1) CY1117162T1 (sl)
DK (1) DK2235064T3 (sl)
ES (2) ES2774337T3 (sl)
HU (1) HUE028536T2 (sl)
MX (1) MX350962B (sl)
PL (1) PL2235064T3 (sl)
PT (1) PT2235064E (sl)
SI (1) SI2235064T1 (sl)
WO (1) WO2009089004A1 (sl)

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