SI3164492T1 - Sistem polipeptidne ekspresije - Google Patents

Sistem polipeptidne ekspresije

Info

Publication number
SI3164492T1
SI3164492T1 SI201531033T SI201531033T SI3164492T1 SI 3164492 T1 SI3164492 T1 SI 3164492T1 SI 201531033 T SI201531033 T SI 201531033T SI 201531033 T SI201531033 T SI 201531033T SI 3164492 T1 SI3164492 T1 SI 3164492T1
Authority
SI
Slovenia
Prior art keywords
expression systems
polypeptide expression
polypeptide
systems
expression
Prior art date
Application number
SI201531033T
Other languages
English (en)
Inventor
Isidro Hotzel
Yonglei Shang
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of SI3164492T1 publication Critical patent/SI3164492T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
SI201531033T 2014-07-03 2015-07-02 Sistem polipeptidne ekspresije SI3164492T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462020838P 2014-07-03 2014-07-03
US201462080698P 2014-11-17 2014-11-17
EP15739141.8A EP3164492B1 (en) 2014-07-03 2015-07-02 Polypeptide expression systems
PCT/US2015/039086 WO2016004370A1 (en) 2014-07-03 2015-07-02 Polypeptide expression systems

Publications (1)

Publication Number Publication Date
SI3164492T1 true SI3164492T1 (sl) 2020-02-28

Family

ID=53674343

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201531033T SI3164492T1 (sl) 2014-07-03 2015-07-02 Sistem polipeptidne ekspresije

Country Status (9)

Country Link
US (2) US10308944B2 (sl)
EP (2) EP3164492B1 (sl)
JP (3) JP6694400B2 (sl)
CN (2) CN106574270B (sl)
ES (1) ES2763526T3 (sl)
HR (1) HRP20192243T1 (sl)
PL (1) PL3164492T3 (sl)
SI (1) SI3164492T1 (sl)
WO (1) WO2016004370A1 (sl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106574270B (zh) * 2014-07-03 2021-07-13 豪夫迈·罗氏有限公司 多肽表达系统
JP2022538598A (ja) * 2019-06-25 2022-09-05 ミガル ガリラヤ リサーチ インスティテュート リミテッド プレｍＲＮＡのトランススプライシングに基づく合成転写用論理「ＡＮＤ」ゲートを作製するためのシステムおよびその使用
JP2022012406A (ja) 2020-07-01 2022-01-17 Ｋｙｂ株式会社 リリーフ弁

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
WO1990005144A1 (en) 1988-11-11 1990-05-17 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
DK0590058T3 (da) 1991-06-14 2004-03-29 Genentech Inc Humaniseret heregulin-antistof
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
EP0625200B1 (en) 1992-02-06 2005-05-11 Chiron Corporation Biosynthetic binding protein for cancer marker
US6150141A (en) * 1993-09-10 2000-11-21 Trustees Of Boston University Intron-mediated recombinant techniques and reagents
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
EP0883344B2 (en) 1995-12-15 2010-06-09 VIRxSYS Corporation Therapeutic molecules generated by trans-splicing
US20030027250A1 (en) * 1995-12-15 2003-02-06 Mitchell Lloyd G. Methods and compositions for use in spliceosome mediated RNA trans-splicing
US20020062010A1 (en) 1997-05-02 2002-05-23 Genentech, Inc. Method for making multispecific antibodies having heteromultimeric and common components
PT1034298E (pt) 1997-12-05 2012-02-03 Scripps Research Inst Humanização de anticorpo murino
CN101289511A (zh) 2000-04-11 2008-10-22 杰南技术公司 多价抗体及其应用
IL136459A0 (en) * 2000-05-30 2001-06-14 Galim Galil Immunology Ltd Antibody library
WO2002053581A2 (en) 2001-01-08 2002-07-11 Intronn, Inc. Spliceosome mediated rna trans-splicing
NZ530852A (en) * 2001-08-27 2006-11-30 Genentech Inc Methods and compositions for recombinantly producing functional antibodies or antibody fragments in prokaryotic and eukaryotic host cells
CN1886512A (zh) * 2002-04-23 2006-12-27 斯克里普斯研究所 多肽在叶绿体中的表达以及用于表达多肽的组合物和方法
KR100465201B1 (ko) * 2002-07-16 2005-01-13 현대모비스 주식회사 안티로크 브레이크 시스템의 액압 제어용 전자식 밸브
JP4773947B2 (ja) 2003-01-09 2011-09-14 マクロジェニクス，インコーポレーテッド 細菌細胞及び哺乳動物細胞における抗体発現のための二重発現ベクター系
JP5128935B2 (ja) 2004-03-31 2013-01-23 ジェネンテック， インコーポレイテッド ヒト化抗ＴＧＦ−β抗体
US20060026422A1 (en) * 2004-07-29 2006-02-02 International Business Machines Corporation Method, apparatus, and product for providing a backup hardware trusted platform module in a hypervisor environment
US7879321B2 (en) * 2004-10-08 2011-02-01 Virxsys Corporation Use of RNA trans-splicing for antibody gene transfer and antibody polypeptide production
AU2006303440B2 (en) * 2005-10-21 2011-09-08 F. Hoffmann-La Roche Ag Method for the recombinant expression of a polypeptide
WO2007147901A1 (en) 2006-06-22 2007-12-27 Novo Nordisk A/S Production of bispecific antibodies
PL2059533T3 (pl) 2006-08-30 2013-04-30 Genentech Inc Przeciwciała wieloswoiste
PL2235064T3 (pl) 2008-01-07 2016-06-30 Amgen Inc Sposób otrzymywania cząsteczek przeciwciał z heterodimerycznymi fc z zastosowaniem kierujących efektów elektrostatycznych
US8313942B2 (en) * 2008-09-26 2012-11-20 Wyeth Llc Compatible display vector systems
SG179196A1 (en) 2009-09-16 2012-04-27 Genentech Inc Coiled coil and/or tether containing protein complexes and uses thereof
PL2643468T3 (pl) * 2010-11-22 2018-11-30 Amicus Therapeutics, Inc. Nowe sekwencje sygnałowe do poprawy ekspresji białek i wydzielania ekombinowanych enzymów i innych białek
CA2877009C (en) * 2012-07-05 2023-10-03 Devin TESAR Expression and secretion system
CN106574270B (zh) * 2014-07-03 2021-07-13 豪夫迈·罗氏有限公司 多肽表达系统

Also Published As

Publication number Publication date
CN113789339A (zh) 2021-12-14
US10308944B2 (en) 2019-06-04
CN106574270A (zh) 2017-04-19
PL3164492T3 (pl) 2020-04-30
HRP20192243T1 (hr) 2020-03-06
CN106574270B (zh) 2021-07-13
US20190256859A1 (en) 2019-08-22
JP2023081910A (ja) 2023-06-13
EP3164492A1 (en) 2017-05-10
US11851661B2 (en) 2023-12-26
US20160002642A1 (en) 2016-01-07
JP6694400B2 (ja) 2020-05-13
EP3680336A1 (en) 2020-07-15
ES2763526T3 (es) 2020-05-29
JP2020114219A (ja) 2020-07-30
EP3164492B1 (en) 2019-10-23
WO2016004370A1 (en) 2016-01-07
JP2017520255A (ja) 2017-07-27

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