MX2016008539A - Variantes de region fc con propiedades de union a receptor fc neonatal (fcrn) modificadas y de union a proteina a mantenidas. - Google Patents
Variantes de region fc con propiedades de union a receptor fc neonatal (fcrn) modificadas y de union a proteina a mantenidas.Info
- Publication number
- MX2016008539A MX2016008539A MX2016008539A MX2016008539A MX2016008539A MX 2016008539 A MX2016008539 A MX 2016008539A MX 2016008539 A MX2016008539 A MX 2016008539A MX 2016008539 A MX2016008539 A MX 2016008539A MX 2016008539 A MX2016008539 A MX 2016008539A
- Authority
- MX
- Mexico
- Prior art keywords
- binding properties
- region variants
- mutations
- polypeptide
- modified fcrn
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
En la presente se describe un polipéptido que comprende un primer polipéptido y un segundo polipéptido, cada uno que comprende en dirección de N-terminal a C-terminal al menos una porción de una región bisagra de inmunoglobulina, que comprende uno o más residuos de cisteína, un dominio CH2 de inmunoglobulina y un dominio CH3 de inmunoglobulina, en donde i) el primer polipéptido comprende las mutaciones I253A, H310A y H435A y el segundo polipéptido comprende las mutaciones H310A, H433A y Y436A, o ii) el primer polipéptido comprende las mutaciones I253A, H310A y H435A y el segundo polipéptido comprende las mutaciones L251D, L314D y L432D, o iii) el primer polipéptido comprende las mutaciones I253A, H310A y H435A y el segundo polipéptido comprende las mutaciones L251S, L314S y L432S.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14151320 | 2014-01-15 | ||
EP14165923 | 2014-04-25 | ||
PCT/EP2015/050426 WO2015107026A1 (en) | 2014-01-15 | 2015-01-12 | Fc-region variants with modified fcrn- and maintained protein a-binding properties |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016008539A true MX2016008539A (es) | 2016-09-26 |
Family
ID=52339150
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016008539A MX2016008539A (es) | 2014-01-15 | 2015-01-12 | Variantes de region fc con propiedades de union a receptor fc neonatal (fcrn) modificadas y de union a proteina a mantenidas. |
Country Status (11)
Country | Link |
---|---|
US (2) | US20170037153A1 (es) |
EP (2) | EP3094647A1 (es) |
JP (2) | JP6786392B2 (es) |
KR (1) | KR20160107190A (es) |
CN (2) | CN110903398B (es) |
BR (1) | BR112016016416A2 (es) |
CA (1) | CA2931986A1 (es) |
HK (1) | HK1223952A1 (es) |
MX (1) | MX2016008539A (es) |
RU (1) | RU2727639C2 (es) |
WO (1) | WO2015107026A1 (es) |
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-
2015
- 2015-01-12 WO PCT/EP2015/050426 patent/WO2015107026A1/en active Application Filing
- 2015-01-12 RU RU2016133346A patent/RU2727639C2/ru active
- 2015-01-12 CN CN201911266804.5A patent/CN110903398B/zh active Active
- 2015-01-12 BR BR112016016416A patent/BR112016016416A2/pt not_active IP Right Cessation
- 2015-01-12 JP JP2016546941A patent/JP6786392B2/ja active Active
- 2015-01-12 CA CA2931986A patent/CA2931986A1/en not_active Abandoned
- 2015-01-12 KR KR1020167019022A patent/KR20160107190A/ko not_active Application Discontinuation
- 2015-01-12 EP EP15700148.8A patent/EP3094647A1/en not_active Ceased
- 2015-01-12 CN CN201580003626.0A patent/CN105899534B/zh active Active
- 2015-01-12 EP EP20214926.6A patent/EP3835318A1/en active Pending
- 2015-01-12 MX MX2016008539A patent/MX2016008539A/es unknown
-
2016
- 2016-07-14 US US15/210,199 patent/US20170037153A1/en not_active Abandoned
- 2016-10-25 HK HK16112241.4A patent/HK1223952A1/zh unknown
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2018
- 2018-04-06 US US15/947,424 patent/US20190016828A1/en active Pending
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2020
- 2020-08-26 JP JP2020142798A patent/JP2020196744A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP6786392B2 (ja) | 2020-11-18 |
CA2931986A1 (en) | 2015-07-23 |
CN105899534A (zh) | 2016-08-24 |
CN110903398B (zh) | 2023-08-15 |
CN105899534B (zh) | 2020-01-07 |
EP3835318A1 (en) | 2021-06-16 |
WO2015107026A1 (en) | 2015-07-23 |
RU2727639C2 (ru) | 2020-07-22 |
US20190016828A1 (en) | 2019-01-17 |
KR20160107190A (ko) | 2016-09-13 |
HK1223952A1 (zh) | 2017-08-11 |
US20170037153A1 (en) | 2017-02-09 |
CN110903398A (zh) | 2020-03-24 |
BR112016016416A2 (pt) | 2017-10-03 |
JP2017505767A (ja) | 2017-02-23 |
EP3094647A1 (en) | 2016-11-23 |
RU2016133346A3 (es) | 2018-11-08 |
RU2016133346A (ru) | 2018-02-20 |
JP2020196744A (ja) | 2020-12-10 |
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