MX342034B - Proteinas monovalentes que se unen a antigenos. - Google Patents

Proteinas monovalentes que se unen a antigenos.

Info

Publication number
MX342034B
MX342034B MX2013009781A MX2013009781A MX342034B MX 342034 B MX342034 B MX 342034B MX 2013009781 A MX2013009781 A MX 2013009781A MX 2013009781 A MX2013009781 A MX 2013009781A MX 342034 B MX342034 B MX 342034B
Authority
MX
Mexico
Prior art keywords
antigen binding
binding proteins
monovalent antigen
monovalent
antibodies
Prior art date
Application number
MX2013009781A
Other languages
English (en)
Other versions
MX2013009781A (es
Inventor
Klein Christian
Bossenmaier Birgit
Kettenberger Hubert
Keunkele Klaus-Peter
Thomas Regula Joerg
Schaefer Wolfgang
Schwaiger Manfred
Sustmann Claudio
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2013009781A publication Critical patent/MX2013009781A/es
Publication of MX342034B publication Critical patent/MX342034B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

La presente invención se refiere a proteínas monovalentes que se unen a antígenos con un intercambio de dominios CH1-CL, a métodos para su producción, a composiciones farmacéuticas que contienen tales anticuerpos y a usos de los mismos.
MX2013009781A 2011-02-28 2012-02-24 Proteinas monovalentes que se unen a antigenos. MX342034B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11156321 2011-02-28
PCT/EP2012/053119 WO2012116927A1 (en) 2011-02-28 2012-02-24 Monovalent antigen binding proteins

Publications (2)

Publication Number Publication Date
MX2013009781A MX2013009781A (es) 2013-09-26
MX342034B true MX342034B (es) 2016-09-12

Family

ID=45819191

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013009781A MX342034B (es) 2011-02-28 2012-02-24 Proteinas monovalentes que se unen a antigenos.

Country Status (11)

Country Link
US (2) US20120237507A1 (es)
EP (1) EP2681240B1 (es)
JP (1) JP5768147B2 (es)
KR (1) KR101572338B1 (es)
CN (1) CN103403025B (es)
AR (1) AR085403A1 (es)
BR (1) BR112013020338A2 (es)
CA (1) CA2824824A1 (es)
MX (1) MX342034B (es)
RU (1) RU2013141078A (es)
WO (1) WO2012116927A1 (es)

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