UY34558A - Proteínas de unión específicas duales dirigidas contra il-13 y/o il-17 - Google Patents

Proteínas de unión específicas duales dirigidas contra il-13 y/o il-17

Info

Publication number
UY34558A
UY34558A UY34558A UY34558A UY34558A UY 34558 A UY34558 A UY 34558A UY 34558 A UY34558 A UY 34558A UY 34558 A UY34558 A UY 34558A UY 34558 A UY34558 A UY 34558A
Authority
UY
Uruguay
Prior art keywords
directed against
dual specific
proteins directed
specific union
union proteins
Prior art date
Application number
UY34558A
Other languages
English (en)
Inventor
Chung-Ming Hsieh
Ghayur Tariq
Carrie L Goodreau
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of UY34558A publication Critical patent/UY34558A/es

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    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5437—IL-13

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Abstract

Proteínas de unión multivalentes y multiespecíficas manipuladas que se unen a la IL-13 y/o a la IL-17, junto con métodos de elaboración y sus usos en la prevención, el diagnóstico y/o tratamiento de una enfermedad
UY34558A 2011-12-30 2012-12-28 Proteínas de unión específicas duales dirigidas contra il-13 y/o il-17 UY34558A (es)

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BR112014015851A2 (pt) 2019-09-24
TW201333035A (zh) 2013-08-16
US9120870B2 (en) 2015-09-01
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WO2013102042A2 (en) 2013-07-04

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