MX2012004412A - Proteinas de union a il-1. - Google Patents

Proteinas de union a il-1.

Info

Publication number
MX2012004412A
MX2012004412A MX2012004412A MX2012004412A MX2012004412A MX 2012004412 A MX2012004412 A MX 2012004412A MX 2012004412 A MX2012004412 A MX 2012004412A MX 2012004412 A MX2012004412 A MX 2012004412A MX 2012004412 A MX2012004412 A MX 2012004412A
Authority
MX
Mexico
Prior art keywords
binding proteins
activity
binding
methods
proteins
Prior art date
Application number
MX2012004412A
Other languages
English (en)
Inventor
Chengbin Wu
Chung-Ming Hsieh
Renne Miller
Dominic J Ambrosi
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2012004412A publication Critical patent/MX2012004412A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/545—IL-1

Abstract

La presente invención describe proteínas de unión a IL1 ß, incluyendo anticuerpos quiméricos, injertados con CDR, y humanizados que se unen a lL-1ß. Las proteínas de unión de la invención tienen alta afinidad para IL-1ß y neutralilzan la actividad de lL-1ß. Una proteína de unión de la invención puede ser un anticuerpo de longitud completa o una porción de unión a lL-1ß del mismo. También se describen métodos para elaborar y métodos para utilizar las proteínas de unión de la invención. Las proteínas de unión a IL-1ß de la invención son útiles para detectar lL-1ß y para inhibir la actividad de IL-1ß, incluyendo en un individuo humano que padece de una enfermedad o trastorno en el cual la actividad de lL-1ß es perjudicial.
MX2012004412A 2009-10-15 2010-10-15 Proteinas de union a il-1. MX2012004412A (es)

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PCT/US2010/052849 WO2011047266A1 (en) 2009-10-15 2010-10-15 Il-1 binding proteins

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RU2012119788A (ru) 2013-11-20
US20110142761A1 (en) 2011-06-16
AU2010306681A1 (en) 2012-04-19
EP2488201A4 (en) 2013-12-25
CN102655880A (zh) 2012-09-05
US20130295004A1 (en) 2013-11-07
JP2013507929A (ja) 2013-03-07
CA2775402A1 (en) 2011-04-21
WO2011047266A1 (en) 2011-04-21
TW201124427A (en) 2011-07-16
US8398966B2 (en) 2013-03-19
EP2488201A1 (en) 2012-08-22
ZA201202610B (en) 2012-12-27
IL219202A0 (en) 2012-06-28
BR112012007365A2 (pt) 2016-11-22
KR20120104542A (ko) 2012-09-21
UY32949A (es) 2011-02-28
IN2012DN02634A (es) 2015-09-04

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