UY32949A - Proteínas de unión a il-1 - Google Patents

Proteínas de unión a il-1

Info

Publication number
UY32949A
UY32949A UY0001032949A UY32949A UY32949A UY 32949 A UY32949 A UY 32949A UY 0001032949 A UY0001032949 A UY 0001032949A UY 32949 A UY32949 A UY 32949A UY 32949 A UY32949 A UY 32949A
Authority
UY
Uruguay
Prior art keywords
binding proteins
activity
binding
proteins
methods
Prior art date
Application number
UY0001032949A
Other languages
English (en)
Inventor
Chung-Ming Hsieh
Chengbin Wu Domicilio
Miller Renee
Dominic J Ambrosi
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of UY32949A publication Critical patent/UY32949A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/545—IL-1

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Abstract

Proteínas de unión a IL-1ß, incluyendo anticuerpos quiméricos, con injerto de CDR y humanizados que se unen a IL-1ß. Las proteínas de unión de la in vención tienen una gran afinidad por la IL-1ß y neutralizan la actividad de la IL-1ß. La proteína d e unión de la invención puede ser un anticuerpo de longitud completa o una -porción de unión a IL-1ß de la misma. Se describen asimismo métodos de e laboración y métodos de uso de las proteínas de unión de la invención. Las proteínas de unión a IL- 1ß de la invención son de utilidad para detectar IL-1ß y para inhibir la actividad de IL-1ß, inclusive en un sujeto humano que sufre de una enfermed ad o trastorno en donde la actividad de la IL-1ß es perjudicial.
UY0001032949A 2009-10-15 2010-10-15 Proteínas de unión a il-1 UY32949A (es)

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EP2488201A1 (en) 2012-08-22
CA2775402A1 (en) 2011-04-21
US8398966B2 (en) 2013-03-19
IN2012DN02634A (es) 2015-09-04
KR20120104542A (ko) 2012-09-21
BR112012007365A2 (pt) 2016-11-22
AR078650A1 (es) 2011-11-23
MX2012004412A (es) 2012-05-08
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RU2012119788A (ru) 2013-11-20

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