DOP2011000232A - Proteinas de union a il-1 - Google Patents

Proteinas de union a il-1

Info

Publication number
DOP2011000232A
DOP2011000232A DO2011000232A DO2011000232A DOP2011000232A DO P2011000232 A DOP2011000232 A DO P2011000232A DO 2011000232 A DO2011000232 A DO 2011000232A DO 2011000232 A DO2011000232 A DO 2011000232A DO P2011000232 A DOP2011000232 A DO P2011000232A
Authority
DO
Dominican Republic
Prior art keywords
antibodies
activity
proteins
antibody
union
Prior art date
Application number
DO2011000232A
Other languages
English (en)
Inventor
Chengbin Wu
Chung-Ming Hsieh
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of DOP2011000232A publication Critical patent/DOP2011000232A/es

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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Abstract

Proteínas que se unen a Ia IL-Ia. Anticuerpos que son anticuerpos quiméricos, anticuerpos que tienen CDR injertadas o anticuerpos humanizados. Los anticuerpos de la invención presentan una afinidad elevada por Ia IL-la y neutralizan la actividad de la IL-la. Un anticuerpo de Ia invención puede ser un anticuerpo completo o una porción de unión aI antígeno de éste. Métodos para elaborar y usar los anticuerpos de la invención. Los anticuerpos o las porciones de anticuerpos de la invención son útiles para detectar Ia IL-la y para inhibir la actividad de la IL- la, por ejemplo, en un sujeto humano que padece un trastorno en eI que la actividad de Ia IL-la es perjudicial.
DO2011000232A 2009-01-29 2011-07-18 Proteinas de union a il-1 DOP2011000232A (es)

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