DK3129470T3 - Behandling af cancer ved anvendelse af anti-CD19-kimær antigenreceptor - Google Patents

Behandling af cancer ved anvendelse af anti-CD19-kimær antigenreceptor Download PDF

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Publication number
DK3129470T3
DK3129470T3 DK15719043.0T DK15719043T DK3129470T3 DK 3129470 T3 DK3129470 T3 DK 3129470T3 DK 15719043 T DK15719043 T DK 15719043T DK 3129470 T3 DK3129470 T3 DK 3129470T3
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Prior art keywords
cancer
treatment
antigen receptor
chimeric antigen
chimeric
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DK15719043.0T
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English (en)
Inventor
John Byrd
Jason Dubovsky
Joseph Fraietta
Saar Gill
David Glass
Amy Johnson
Carl H June
Saad Kenderian
Joan Mannick
Marcela Maus
Leon Murphy
Natarajan Muthusamy
David L Porter
Marco Ruella
William Raj Sellers
Mariusz Wasik
Jennifer Brogdon
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Novartis Ag
Univ Pennsylvania
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Publication of DK3129470T3 publication Critical patent/DK3129470T3/da

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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DK15719043.0T 2014-04-07 2015-04-07 Behandling af cancer ved anvendelse af anti-CD19-kimær antigenreceptor DK3129470T3 (da)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461976396P 2014-04-07 2014-04-07
US201462007309P 2014-06-03 2014-06-03
US201462036493P 2014-08-12 2014-08-12
US201462076238P 2014-11-06 2014-11-06
US201462087888P 2014-12-05 2014-12-05
US201462097278P 2014-12-29 2014-12-29
PCT/US2015/024671 WO2015157252A1 (en) 2014-04-07 2015-04-07 Treatment of cancer using anti-cd19 chimeric antigen receptor

Publications (1)

Publication Number Publication Date
DK3129470T3 true DK3129470T3 (da) 2021-07-05

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DK15719043.0T DK3129470T3 (da) 2014-04-07 2015-04-07 Behandling af cancer ved anvendelse af anti-CD19-kimær antigenreceptor

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US (2) US10357514B2 (da)
EP (2) EP3129470B1 (da)
JP (3) JP6765966B2 (da)
KR (3) KR20240042250A (da)
CN (2) CN107075482B (da)
AU (2) AU2015244039B2 (da)
CA (1) CA2940671A1 (da)
DK (1) DK3129470T3 (da)
ES (1) ES2876263T3 (da)
HR (1) HRP20211055T1 (da)
HU (1) HUE054588T2 (da)
IL (4) IL280215B (da)
LT (1) LT3129470T (da)
MX (2) MX2016013239A (da)
MY (1) MY191608A (da)
PL (1) PL3129470T3 (da)
PT (1) PT3129470T (da)
RU (1) RU2718542C2 (da)
SG (2) SG10202109752XA (da)
SI (1) SI3129470T1 (da)
TW (1) TWI753848B (da)
WO (1) WO2015157252A1 (da)
ZA (1) ZA201605657B (da)

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RU2019137208A (ru) 2013-02-20 2020-02-19 Новартис Аг ЛЕЧЕНИЕ РАКА С ИСПОЛЬЗОВАНИЕМ ХИМЕРНОГО АНТИГЕНСПЕЦИФИЧЕСКОГО РЕЦЕПТОРА НА ОСНОВЕ ГУМАНИЗИРОВАННОГО АНТИТЕЛА ПРОТИВ EGFRvIII
EP3623380A1 (en) 2013-03-15 2020-03-18 Michael C. Milone Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
TWI654206B (zh) 2013-03-16 2019-03-21 諾華公司 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症
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