DK3083689T3 - Anti-CD3-antistoffer og fremgangsmåder til anvendelse - Google Patents

Anti-CD3-antistoffer og fremgangsmåder til anvendelse Download PDF

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Publication number
DK3083689T3
DK3083689T3 DK14828608.1T DK14828608T DK3083689T3 DK 3083689 T3 DK3083689 T3 DK 3083689T3 DK 14828608 T DK14828608 T DK 14828608T DK 3083689 T3 DK3083689 T3 DK 3083689T3
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antibodies
methods
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DK14828608.1T
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Inventor
Allen J Ebens Jr
Xiaocheng Chen
Teemu T Junttila
Robert F Kelley
Mary A Mathieu
Liping L Sun
Mark S Dennis
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Genentech Inc
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
DK14828608.1T 2013-12-17 2014-12-17 Anti-CD3-antistoffer og fremgangsmåder til anvendelse DK3083689T3 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361917346P 2013-12-17 2013-12-17
US201461949950P 2014-03-07 2014-03-07
US201462026594P 2014-07-18 2014-07-18
US201462053582P 2014-09-22 2014-09-22
US201462091441P 2014-12-12 2014-12-12
PCT/US2014/070951 WO2015095392A1 (en) 2013-12-17 2014-12-17 Anti-cd3 antibodies and methods of use

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DK3083689T3 true DK3083689T3 (da) 2020-08-03

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DK17156352.1T DK3192812T3 (da) 2013-12-17 2014-12-17 Anti-CD3-antistoffer og fremgangsmåder til anvendelse

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US (7) US10174124B2 (da)
EP (3) EP3192812B1 (da)
JP (6) JP6449295B2 (da)
KR (5) KR102433591B1 (da)
CN (4) CN112390883A (da)
AU (3) AU2014364805B2 (da)
BR (3) BR122021025085B1 (da)
CA (3) CA2932288C (da)
CL (1) CL2016001556A1 (da)
CR (1) CR20160314A (da)
DK (2) DK3083689T3 (da)
EA (1) EA038933B1 (da)
ES (2) ES2811923T3 (da)
FR (1) FR22C1048I2 (da)
HR (2) HRP20201143T1 (da)
HU (3) HUE050159T2 (da)
IL (3) IL302303A (da)
LT (3) LT3192812T (da)
MX (2) MX2016007958A (da)
NL (1) NL301194I2 (da)
NZ (1) NZ721309A (da)
PE (3) PE20210648A1 (da)
PH (1) PH12016501186A1 (da)
PL (2) PL3192812T3 (da)
PT (2) PT3192812T (da)
RS (2) RS60443B1 (da)
SG (3) SG10201809385RA (da)
SI (2) SI3083689T1 (da)
TW (3) TWI747385B (da)
UA (1) UA120753C2 (da)
WO (1) WO2015095392A1 (da)
ZA (2) ZA201603755B (da)

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