ECSP11011239A - Proteínas ligadoras il-1 - Google Patents
Proteínas ligadoras il-1Info
- Publication number
- ECSP11011239A ECSP11011239A EC2011011239A ECSP11011239A ECSP11011239A EC SP11011239 A ECSP11011239 A EC SP11011239A EC 2011011239 A EC2011011239 A EC 2011011239A EC SP11011239 A ECSP11011239 A EC SP11011239A EC SP11011239 A ECSP11011239 A EC SP11011239A
- Authority
- EC
- Ecuador
- Prior art keywords
- antibodies
- activity
- antibody
- binding proteins
- elaboration
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
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Abstract
La presente invención abarca las proteínas ligadoras IL-1 . En concreto, la invención se refiere a los anticuerpos que son anticuerpos quiméricos, CDR injertados y anticuerpos humanizados. Los anticuerpos de la invención tienen una alta afinidad para la IL-1 y neutralizar la actividad de la IL-1 . Un anticuerpo de la invención puede ser un anticuerpo de longitud completa o una porción de unión al antígeno de los mismos. Método de elaboración y método de uso de los anticuerpos de la invención también se proporcionan. Los anticuerpos, o porciones de anticuerpo de la invención son útiles para la detección de IL-1 y para inhibir la actividad de la IL-1 , por ejemplo, en un ser humano que sufre de un trastorno en el que la actividad de la IL-1 es perjudicial.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US20625009P | 2009-01-29 | 2009-01-29 |
Publications (1)
Publication Number | Publication Date |
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ECSP11011239A true ECSP11011239A (es) | 2011-08-31 |
Family
ID=42396257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EC2011011239A ECSP11011239A (es) | 2009-01-29 | 2011-07-28 | Proteínas ligadoras il-1 |
Country Status (23)
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US (2) | US8383778B2 (es) |
EP (1) | EP2391652A4 (es) |
JP (1) | JP2012516153A (es) |
KR (1) | KR20110110349A (es) |
CN (1) | CN102369217A (es) |
AU (1) | AU2010208637A1 (es) |
BR (1) | BRPI1007371A2 (es) |
CA (1) | CA2749966A1 (es) |
CL (1) | CL2011001834A1 (es) |
CO (1) | CO6400231A2 (es) |
CR (1) | CR20110577A (es) |
DO (1) | DOP2011000232A (es) |
EC (1) | ECSP11011239A (es) |
IL (1) | IL214341A0 (es) |
MX (1) | MX2011007987A (es) |
NZ (1) | NZ593905A (es) |
PE (1) | PE20120586A1 (es) |
RU (1) | RU2011135768A (es) |
SG (1) | SG172855A1 (es) |
TW (1) | TW201031421A (es) |
UA (1) | UA102722C2 (es) |
WO (1) | WO2010087972A2 (es) |
ZA (1) | ZA201105177B (es) |
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ES2567198T3 (es) * | 2003-01-24 | 2016-04-20 | Applied Molecular Evolution, Inc. | Antagonistas de la IL-1 beta humana |
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CN101203241B (zh) * | 2005-04-19 | 2012-02-22 | 西雅图基因公司 | 人源化抗-cd70结合物和其应用 |
PL2322552T3 (pl) * | 2005-06-21 | 2016-08-31 | Xoma Us Llc | PRZECIWCIAŁA WIĄŻĄCE IL-1β I ICH FRAGMENTY |
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NZ612578A (en) * | 2005-08-19 | 2014-11-28 | Abbvie Inc | Dual variable domain immunoglobin and uses thereof |
US20090215992A1 (en) * | 2005-08-19 | 2009-08-27 | Chengbin Wu | Dual variable domain immunoglobulin and uses thereof |
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EP2471818A1 (en) | 2006-11-02 | 2012-07-04 | Genentech, Inc. | Humanized anti-factor D antibodies and uses thereof |
BRPI1007371A2 (pt) | 2009-01-29 | 2018-03-27 | Abbott Lab | proteínas de ligação a il-1 |
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-
2010
- 2010-01-29 BR BRPI1007371A patent/BRPI1007371A2/pt not_active IP Right Cessation
- 2010-01-29 UA UAA201110369A patent/UA102722C2/ru unknown
- 2010-01-29 CA CA2749966A patent/CA2749966A1/en not_active Abandoned
- 2010-01-29 SG SG2011049012A patent/SG172855A1/en unknown
- 2010-01-29 EP EP10736144A patent/EP2391652A4/en not_active Withdrawn
- 2010-01-29 MX MX2011007987A patent/MX2011007987A/es not_active Application Discontinuation
- 2010-01-29 RU RU2011135768/10A patent/RU2011135768A/ru not_active Application Discontinuation
- 2010-01-29 KR KR1020117019626A patent/KR20110110349A/ko not_active Application Discontinuation
- 2010-01-29 PE PE2011001415A patent/PE20120586A1/es not_active Application Discontinuation
- 2010-01-29 NZ NZ593905A patent/NZ593905A/xx not_active IP Right Cessation
- 2010-01-29 CN CN2010800144900A patent/CN102369217A/zh active Pending
- 2010-01-29 US US12/696,314 patent/US8383778B2/en active Active
- 2010-01-29 WO PCT/US2010/000244 patent/WO2010087972A2/en active Application Filing
- 2010-01-29 TW TW099102701A patent/TW201031421A/zh unknown
- 2010-01-29 AU AU2010208637A patent/AU2010208637A1/en not_active Abandoned
- 2010-01-29 JP JP2011547978A patent/JP2012516153A/ja active Pending
-
2011
- 2011-07-08 CO CO11085495A patent/CO6400231A2/es not_active Application Discontinuation
- 2011-07-13 ZA ZA2011/05177A patent/ZA201105177B/en unknown
- 2011-07-18 DO DO2011000232A patent/DOP2011000232A/es unknown
- 2011-07-28 EC EC2011011239A patent/ECSP11011239A/es unknown
- 2011-07-28 CL CL2011001834A patent/CL2011001834A1/es unknown
- 2011-07-28 IL IL214341A patent/IL214341A0/en unknown
- 2011-11-07 CR CR20110577A patent/CR20110577A/es unknown
-
2013
- 2013-02-06 US US13/760,729 patent/US20130280253A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CL2011001834A1 (es) | 2012-03-09 |
UA102722C2 (en) | 2013-08-12 |
CN102369217A (zh) | 2012-03-07 |
EP2391652A2 (en) | 2011-12-07 |
WO2010087972A3 (en) | 2010-09-16 |
US20130280253A1 (en) | 2013-10-24 |
IL214341A0 (en) | 2011-09-27 |
NZ593905A (en) | 2013-03-28 |
AU2010208637A1 (en) | 2011-08-04 |
CO6400231A2 (es) | 2012-03-15 |
KR20110110349A (ko) | 2011-10-06 |
MX2011007987A (es) | 2011-08-17 |
JP2012516153A (ja) | 2012-07-19 |
ZA201105177B (en) | 2012-03-28 |
RU2011135768A (ru) | 2013-03-10 |
TW201031421A (en) | 2010-09-01 |
EP2391652A4 (en) | 2013-01-02 |
PE20120586A1 (es) | 2012-06-17 |
CA2749966A1 (en) | 2010-08-05 |
DOP2011000232A (es) | 2011-09-15 |
CR20110577A (es) | 2012-02-24 |
SG172855A1 (en) | 2011-08-29 |
WO2010087972A2 (en) | 2010-08-05 |
US20100221179A1 (en) | 2010-09-02 |
US8383778B2 (en) | 2013-02-26 |
BRPI1007371A2 (pt) | 2018-03-27 |
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