CO6400231A2 - Proteínas de unión a il-1 - Google Patents
Proteínas de unión a il-1Info
- Publication number
- CO6400231A2 CO6400231A2 CO11085495A CO11085495A CO6400231A2 CO 6400231 A2 CO6400231 A2 CO 6400231A2 CO 11085495 A CO11085495 A CO 11085495A CO 11085495 A CO11085495 A CO 11085495A CO 6400231 A2 CO6400231 A2 CO 6400231A2
- Authority
- CO
- Colombia
- Prior art keywords
- antibodies
- activity
- antibody
- proteins
- union
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
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- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
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Abstract
La presente invención abarca proteínas de unión a IL-1a. Específicamente, la invención se relaciona con anticuerpos que son anticuerpos quiméricos, de CDR injertada y humanizados. Los anticuerpos de la invención tienen alta afinidad por IL-1a y neutralizan la actividad de IL-1a. Un anticuerpo de la invención puede ser un anticuerpo de longitud total o una porción de unión a antígeno del mismo. También se provee el método para preparar y el método para usar los anticuerpos de la invención. Los anticuerpos, o porciones de anticuerpo de la invención son útiles para detectar una IL-1a y para inhibir la actividad de IL-1a, p.e., en un sujeto humano que sufre de un trastorno en el cual la actividad de IL-1a es perjudicial.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US20625009P | 2009-01-29 | 2009-01-29 |
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CO6400231A2 true CO6400231A2 (es) | 2012-03-15 |
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CO11085495A CO6400231A2 (es) | 2009-01-29 | 2011-07-08 | Proteínas de unión a il-1 |
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US (2) | US8383778B2 (es) |
EP (1) | EP2391652A4 (es) |
JP (1) | JP2012516153A (es) |
KR (1) | KR20110110349A (es) |
CN (1) | CN102369217A (es) |
AU (1) | AU2010208637A1 (es) |
BR (1) | BRPI1007371A2 (es) |
CA (1) | CA2749966A1 (es) |
CL (1) | CL2011001834A1 (es) |
CO (1) | CO6400231A2 (es) |
CR (1) | CR20110577A (es) |
DO (1) | DOP2011000232A (es) |
EC (1) | ECSP11011239A (es) |
IL (1) | IL214341A0 (es) |
MX (1) | MX2011007987A (es) |
NZ (1) | NZ593905A (es) |
PE (1) | PE20120586A1 (es) |
RU (1) | RU2011135768A (es) |
SG (1) | SG172855A1 (es) |
TW (1) | TW201031421A (es) |
UA (1) | UA102722C2 (es) |
WO (1) | WO2010087972A2 (es) |
ZA (1) | ZA201105177B (es) |
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US20090215992A1 (en) * | 2005-08-19 | 2009-08-27 | Chengbin Wu | Dual variable domain immunoglobulin and uses thereof |
SG2014010029A (en) * | 2005-08-19 | 2014-08-28 | Abbott Lab | Dual variable domain immunoglobin and uses thereof |
EP2057191A1 (en) * | 2006-08-18 | 2009-05-13 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
UA116614C2 (uk) | 2006-11-02 | 2018-04-25 | Дженентек, Інк. | Антитіло до фактора d і його застосування |
WO2010087972A2 (en) | 2009-01-29 | 2010-08-05 | Abbott Laboratories | Il-1 binding proteins |
US20110016506A1 (en) * | 2009-07-15 | 2011-01-20 | Yung-Yu Lu | Set-Top Box |
NZ628792A (en) * | 2010-05-14 | 2016-03-31 | Abbvie Inc | Il-1 binding proteins |
-
2010
- 2010-01-29 WO PCT/US2010/000244 patent/WO2010087972A2/en active Application Filing
- 2010-01-29 PE PE2011001415A patent/PE20120586A1/es not_active Application Discontinuation
- 2010-01-29 JP JP2011547978A patent/JP2012516153A/ja active Pending
- 2010-01-29 KR KR1020117019626A patent/KR20110110349A/ko not_active Application Discontinuation
- 2010-01-29 CN CN2010800144900A patent/CN102369217A/zh active Pending
- 2010-01-29 CA CA2749966A patent/CA2749966A1/en not_active Abandoned
- 2010-01-29 UA UAA201110369A patent/UA102722C2/ru unknown
- 2010-01-29 NZ NZ593905A patent/NZ593905A/xx not_active IP Right Cessation
- 2010-01-29 MX MX2011007987A patent/MX2011007987A/es not_active Application Discontinuation
- 2010-01-29 SG SG2011049012A patent/SG172855A1/en unknown
- 2010-01-29 AU AU2010208637A patent/AU2010208637A1/en not_active Abandoned
- 2010-01-29 EP EP10736144A patent/EP2391652A4/en not_active Withdrawn
- 2010-01-29 TW TW099102701A patent/TW201031421A/zh unknown
- 2010-01-29 BR BRPI1007371A patent/BRPI1007371A2/pt not_active IP Right Cessation
- 2010-01-29 US US12/696,314 patent/US8383778B2/en active Active
- 2010-01-29 RU RU2011135768/10A patent/RU2011135768A/ru not_active Application Discontinuation
-
2011
- 2011-07-08 CO CO11085495A patent/CO6400231A2/es not_active Application Discontinuation
- 2011-07-13 ZA ZA2011/05177A patent/ZA201105177B/en unknown
- 2011-07-18 DO DO2011000232A patent/DOP2011000232A/es unknown
- 2011-07-28 IL IL214341A patent/IL214341A0/en unknown
- 2011-07-28 CL CL2011001834A patent/CL2011001834A1/es unknown
- 2011-07-28 EC EC2011011239A patent/ECSP11011239A/es unknown
- 2011-11-07 CR CR20110577A patent/CR20110577A/es unknown
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2013
- 2013-02-06 US US13/760,729 patent/US20130280253A1/en not_active Abandoned
Also Published As
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CL2011001834A1 (es) | 2012-03-09 |
PE20120586A1 (es) | 2012-06-17 |
WO2010087972A2 (en) | 2010-08-05 |
UA102722C2 (en) | 2013-08-12 |
CR20110577A (es) | 2012-02-24 |
TW201031421A (en) | 2010-09-01 |
EP2391652A4 (en) | 2013-01-02 |
KR20110110349A (ko) | 2011-10-06 |
WO2010087972A3 (en) | 2010-09-16 |
US8383778B2 (en) | 2013-02-26 |
NZ593905A (en) | 2013-03-28 |
CA2749966A1 (en) | 2010-08-05 |
JP2012516153A (ja) | 2012-07-19 |
AU2010208637A1 (en) | 2011-08-04 |
BRPI1007371A2 (pt) | 2018-03-27 |
EP2391652A2 (en) | 2011-12-07 |
MX2011007987A (es) | 2011-08-17 |
DOP2011000232A (es) | 2011-09-15 |
CN102369217A (zh) | 2012-03-07 |
SG172855A1 (en) | 2011-08-29 |
RU2011135768A (ru) | 2013-03-10 |
IL214341A0 (en) | 2011-09-27 |
US20100221179A1 (en) | 2010-09-02 |
ZA201105177B (en) | 2012-03-28 |
US20130280253A1 (en) | 2013-10-24 |
ECSP11011239A (es) | 2011-08-31 |
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