BR112017021500A2 - terapias com cd20, terapias com cd22 e terapias de combinação com uma célula que expressa (car) receptor de antígeno quimérico de cd19 - Google Patents
terapias com cd20, terapias com cd22 e terapias de combinação com uma célula que expressa (car) receptor de antígeno quimérico de cd19Info
- Publication number
- BR112017021500A2 BR112017021500A2 BR112017021500-4A BR112017021500A BR112017021500A2 BR 112017021500 A2 BR112017021500 A2 BR 112017021500A2 BR 112017021500 A BR112017021500 A BR 112017021500A BR 112017021500 A2 BR112017021500 A2 BR 112017021500A2
- Authority
- BR
- Brazil
- Prior art keywords
- therapies
- car
- combination
- antigen receptor
- chimeric antigen
- Prior art date
Links
- 238000002648 combination therapy Methods 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000009097 single-agent therapy Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/00—Immunoglobulins specific features
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Abstract
a presente invenção refere-se a composições e métodos para tratar doenças associadas com a expressão de cd19, por exemplo, ao administrar uma célula t recombinante compreendendo o car de cd19 conforme descrito no presente documento, em combinação com um ou mais inibidores de célula b, por exemplo, inibidores de um ou mais de cd10, cd20, cd22, cd34, cd123, flt-3, ror1, cd79b, cd179b ou cd79a. a descrição adicionalmente destaca novos domí-nios de ligação aos antígenos e moléculas de car direcionadas a cd20 e cd22, e usos, por exemplo, como monoterapias ou em terapias de combinação. a invenção também provê kits e composições descritos no presente documento.
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562144639P | 2015-04-08 | 2015-04-08 | |
US201562144615P | 2015-04-08 | 2015-04-08 | |
US201562144497P | 2015-04-08 | 2015-04-08 | |
US62/144,639 | 2015-04-08 | ||
US62/144,615 | 2015-04-08 | ||
US62/144,497 | 2015-04-08 | ||
US201562207255P | 2015-08-19 | 2015-08-19 | |
US62/207,255 | 2015-08-19 | ||
US201562263423P | 2015-12-04 | 2015-12-04 | |
US62/263,423 | 2015-12-04 | ||
PCT/US2016/026655 WO2016164731A2 (en) | 2015-04-08 | 2016-04-08 | Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell |
Publications (1)
Publication Number | Publication Date |
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BR112017021500A2 true BR112017021500A2 (pt) | 2018-09-25 |
Family
ID=55861177
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017021500-4A BR112017021500A2 (pt) | 2015-04-08 | 2016-04-08 | terapias com cd20, terapias com cd22 e terapias de combinação com uma célula que expressa (car) receptor de antígeno quimérico de cd19 |
Country Status (24)
Country | Link |
---|---|
US (4) | US10253086B2 (pt) |
EP (2) | EP4056588A1 (pt) |
JP (3) | JP6961490B2 (pt) |
KR (1) | KR20170134642A (pt) |
CN (2) | CN114958764A (pt) |
AU (2) | AU2016245958B2 (pt) |
BR (1) | BR112017021500A2 (pt) |
CA (1) | CA2981751A1 (pt) |
CO (1) | CO2017010190A2 (pt) |
DK (1) | DK3280729T3 (pt) |
ES (1) | ES2923894T3 (pt) |
HK (1) | HK1243101A1 (pt) |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] |