MX2020004948A - Receptor de antígeno quimérico que selecciona como diana bcma, receptor de antígeno quimérico que selecciona como diana cd19 y terapias de combinación. - Google Patents
Receptor de antígeno quimérico que selecciona como diana bcma, receptor de antígeno quimérico que selecciona como diana cd19 y terapias de combinación.Info
- Publication number
- MX2020004948A MX2020004948A MX2020004948A MX2020004948A MX2020004948A MX 2020004948 A MX2020004948 A MX 2020004948A MX 2020004948 A MX2020004948 A MX 2020004948A MX 2020004948 A MX2020004948 A MX 2020004948A MX 2020004948 A MX2020004948 A MX 2020004948A
- Authority
- MX
- Mexico
- Prior art keywords
- antigen receptor
- chimeric antigen
- targeting chimeric
- bcma
- combination therapies
- Prior art date
Links
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 title abstract 4
- 238000002648 combination therapy Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 abstract 1
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 abstract 1
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
La invención proporciona composiciones y métodos para tratar enfermedades asociadas con la expresión de BCMA. La invención también se refiere a un método de administración de una terapia de receptor de antígeno quimérico que selecciona como diana BCMA (CAR) y un agente terapéutico adicional.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762586834P | 2017-11-15 | 2017-11-15 | |
US201762588836P | 2017-11-20 | 2017-11-20 | |
PCT/US2018/061239 WO2019099639A1 (en) | 2017-11-15 | 2018-11-15 | Bcma-targeting chimeric antigen receptor, cd19-targeting chimeric antigen receptor, and combination therapies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020004948A true MX2020004948A (es) | 2020-11-11 |
Family
ID=64664435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020004948A MX2020004948A (es) | 2017-11-15 | 2018-11-15 | Receptor de antígeno quimérico que selecciona como diana bcma, receptor de antígeno quimérico que selecciona como diana cd19 y terapias de combinación. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20200360431A1 (es) |
EP (1) | EP3710040A1 (es) |
JP (1) | JP2021502979A (es) |
KR (1) | KR20200089285A (es) |
CN (1) | CN111787938A (es) |
AU (1) | AU2018369883A1 (es) |
BR (1) | BR112020009336A2 (es) |
CA (1) | CA3088095A1 (es) |
IL (1) | IL274617A (es) |
MX (1) | MX2020004948A (es) |
RU (1) | RU2020119365A (es) |
SG (1) | SG11202004512XA (es) |
TW (1) | TW201922774A (es) |
WO (1) | WO2019099639A1 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8415150B2 (en) * | 2009-02-24 | 2013-04-09 | The Trustees Of The University Of Pennsylvania | Methods for treating progressive multifocal leukoencephalopathy (PML) |
WO2014130657A1 (en) | 2013-02-20 | 2014-08-28 | The Trustees Of The University Of Pennsylvania | Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor |
ES2769574T3 (es) | 2013-03-15 | 2020-06-26 | Michael C Milone | Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva |
US10287354B2 (en) | 2013-12-20 | 2019-05-14 | Novartis Ag | Regulatable chimeric antigen receptor |
DK3183268T3 (da) | 2014-08-19 | 2020-05-11 | Univ Pennsylvania | Behandling af cancer ved anvendelse af en cd123-kimær antigenreceptor |
MX2017012939A (es) | 2015-04-08 | 2018-05-22 | Novartis Ag | Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19. |
AU2016249005B2 (en) | 2015-04-17 | 2022-06-16 | Novartis Ag | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
WO2017027392A1 (en) | 2015-08-07 | 2017-02-16 | Novartis Ag | Treatment of cancer using chimeric cd3 receptor proteins |
CN108780084B (zh) | 2015-09-03 | 2022-07-22 | 诺华股份有限公司 | 预测细胞因子释放综合征的生物标志物 |
EP3432924A1 (en) | 2016-03-23 | 2019-01-30 | Novartis AG | Cell secreted minibodies and uses thereof |
US10525083B2 (en) | 2016-10-07 | 2020-01-07 | Novartis Ag | Nucleic acid molecules encoding chimeric antigen receptors comprising a CD20 binding domain |
WO2018140725A1 (en) | 2017-01-26 | 2018-08-02 | Novartis Ag | Cd28 compositions and methods for chimeric antigen receptor therapy |
JP2021501570A (ja) | 2017-10-18 | 2021-01-21 | ノバルティス アーゲー | 選択的タンパク質分解のための組成物及び方法 |
SG11202011830SA (en) | 2018-06-13 | 2020-12-30 | Novartis Ag | Bcma chimeric antigen receptors and uses thereof |
CN114945382A (zh) | 2019-11-26 | 2022-08-26 | 诺华股份有限公司 | Cd19和cd22嵌合抗原受体及其用途 |
US20230174944A1 (en) * | 2020-04-15 | 2023-06-08 | Cartesian Therapeutics, Inc. | Engineered cells secreting therapeutic enzymes |
US20230203178A1 (en) * | 2020-07-06 | 2023-06-29 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Chimeric antigen receptor car or car construct targeting bcma and cd19 and application thereof |
US20220031751A1 (en) | 2020-08-03 | 2022-02-03 | Kyverna Therapeutics, Inc. | Methods of producing t regulatory cells, methods of transducing t cells, and uses of the same |
EP3954378A1 (en) * | 2020-08-11 | 2022-02-16 | Sandoz AG | Compositions comprising t-cells for topical administration to the lung |
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BR112020009336A2 (pt) | 2020-10-27 |
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AU2018369883A1 (en) | 2020-05-28 |
WO2019099639A8 (en) | 2019-10-31 |
KR20200089285A (ko) | 2020-07-24 |
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