MX2020004948A - Receptor de antígeno quimérico que selecciona como diana bcma, receptor de antígeno quimérico que selecciona como diana cd19 y terapias de combinación. - Google Patents

Receptor de antígeno quimérico que selecciona como diana bcma, receptor de antígeno quimérico que selecciona como diana cd19 y terapias de combinación.

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Publication number
MX2020004948A
MX2020004948A MX2020004948A MX2020004948A MX2020004948A MX 2020004948 A MX2020004948 A MX 2020004948A MX 2020004948 A MX2020004948 A MX 2020004948A MX 2020004948 A MX2020004948 A MX 2020004948A MX 2020004948 A MX2020004948 A MX 2020004948A
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Mexico
Prior art keywords
antigen receptor
chimeric antigen
targeting chimeric
bcma
combination therapies
Prior art date
Application number
MX2020004948A
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English (en)
Inventor
Gabriela Plesa
Carl H June
Alfred Garfall
Adam David Cohen
Michael C Milone
Edward A Stadtmauer
Original Assignee
Novartis Ag
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Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2020004948A publication Critical patent/MX2020004948A/es

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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Abstract

La invención proporciona composiciones y métodos para tratar enfermedades asociadas con la expresión de BCMA. La invención también se refiere a un método de administración de una terapia de receptor de antígeno quimérico que selecciona como diana BCMA (CAR) y un agente terapéutico adicional.
MX2020004948A 2017-11-15 2018-11-15 Receptor de antígeno quimérico que selecciona como diana bcma, receptor de antígeno quimérico que selecciona como diana cd19 y terapias de combinación. MX2020004948A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762586834P 2017-11-15 2017-11-15
US201762588836P 2017-11-20 2017-11-20
PCT/US2018/061239 WO2019099639A1 (en) 2017-11-15 2018-11-15 Bcma-targeting chimeric antigen receptor, cd19-targeting chimeric antigen receptor, and combination therapies

Publications (1)

Publication Number Publication Date
MX2020004948A true MX2020004948A (es) 2020-11-11

Family

ID=64664435

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Application Number Title Priority Date Filing Date
MX2020004948A MX2020004948A (es) 2017-11-15 2018-11-15 Receptor de antígeno quimérico que selecciona como diana bcma, receptor de antígeno quimérico que selecciona como diana cd19 y terapias de combinación.

Country Status (14)

Country Link
US (1) US20200360431A1 (es)
EP (1) EP3710040A1 (es)
JP (1) JP2021502979A (es)
KR (1) KR20200089285A (es)
CN (1) CN111787938A (es)
AU (1) AU2018369883A1 (es)
BR (1) BR112020009336A2 (es)
CA (1) CA3088095A1 (es)
IL (1) IL274617A (es)
MX (1) MX2020004948A (es)
RU (1) RU2020119365A (es)
SG (1) SG11202004512XA (es)
TW (1) TW201922774A (es)
WO (1) WO2019099639A1 (es)

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ES2769574T3 (es) 2013-03-15 2020-06-26 Michael C Milone Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva
US10287354B2 (en) 2013-12-20 2019-05-14 Novartis Ag Regulatable chimeric antigen receptor
DK3183268T3 (da) 2014-08-19 2020-05-11 Univ Pennsylvania Behandling af cancer ved anvendelse af en cd123-kimær antigenreceptor
MX2017012939A (es) 2015-04-08 2018-05-22 Novartis Ag Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19.
AU2016249005B2 (en) 2015-04-17 2022-06-16 Novartis Ag Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
WO2017027392A1 (en) 2015-08-07 2017-02-16 Novartis Ag Treatment of cancer using chimeric cd3 receptor proteins
CN108780084B (zh) 2015-09-03 2022-07-22 诺华股份有限公司 预测细胞因子释放综合征的生物标志物
EP3432924A1 (en) 2016-03-23 2019-01-30 Novartis AG Cell secreted minibodies and uses thereof
US10525083B2 (en) 2016-10-07 2020-01-07 Novartis Ag Nucleic acid molecules encoding chimeric antigen receptors comprising a CD20 binding domain
WO2018140725A1 (en) 2017-01-26 2018-08-02 Novartis Ag Cd28 compositions and methods for chimeric antigen receptor therapy
JP2021501570A (ja) 2017-10-18 2021-01-21 ノバルティス アーゲー 選択的タンパク質分解のための組成物及び方法
SG11202011830SA (en) 2018-06-13 2020-12-30 Novartis Ag Bcma chimeric antigen receptors and uses thereof
CN114945382A (zh) 2019-11-26 2022-08-26 诺华股份有限公司 Cd19和cd22嵌合抗原受体及其用途
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US20230203178A1 (en) * 2020-07-06 2023-06-29 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Chimeric antigen receptor car or car construct targeting bcma and cd19 and application thereof
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EP3954378A1 (en) * 2020-08-11 2022-02-16 Sandoz AG Compositions comprising t-cells for topical administration to the lung
EP4196231A1 (en) * 2020-08-14 2023-06-21 H. Lee Moffitt Cancer Center & Research Institute, Inc. Chimeric antigen receptor t cells for treating autoimmunity
CN112409414B (zh) * 2020-12-01 2021-10-26 北京师范大学 锝-99m标记含异腈的FAPI衍生物及制备方法和应用
CN112321713B (zh) * 2020-12-31 2021-05-25 北京艺妙神州医药科技有限公司 一种抗bcma的抗体及其应用
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