BR112017001242A2 - tratamento de câncer usando um receptor antigênico quimérico a cd33 - Google Patents

tratamento de câncer usando um receptor antigênico quimérico a cd33

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Publication number
BR112017001242A2
BR112017001242A2 BR112017001242A BR112017001242A BR112017001242A2 BR 112017001242 A2 BR112017001242 A2 BR 112017001242A2 BR 112017001242 A BR112017001242 A BR 112017001242A BR 112017001242 A BR112017001242 A BR 112017001242A BR 112017001242 A2 BR112017001242 A2 BR 112017001242A2
Authority
BR
Brazil
Prior art keywords
antigen receptor
cancer treatment
chimeric antigen
car
relates
Prior art date
Application number
BR112017001242A
Other languages
English (en)
Inventor
Richardson Celeste
Glass David
Ebersbach Hilmar
Song Huijuan
Brogdon Jennifer
Zhang Jiquan
Mannick Joan
Jascur Julia
Murphy Leon
C Milone Michael
Wu Qilong
Singh Reshma
Kenderian Saad
Gill Saar
Huber Thomas
Original Assignee
Novartis Ag
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Univ Pennsylvania filed Critical Novartis Ag
Publication of BR112017001242A2 publication Critical patent/BR112017001242A2/pt

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    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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Abstract

a presente invenção refere-se a composições e métodos para o tratamento de doenças associadas à expressão de cd33. a invenção também se refere a receptor antigênico quimérico (car) específico para cd33, vetores que codificam o mesmo e células t recombinantes que compreendem o car de cd33. a invenção também inclui métodos de administração de uma célula t geneticamente modificada que expressa um car que compreende um domínio de ligação a cd33.
BR112017001242A 2014-07-21 2015-07-21 tratamento de câncer usando um receptor antigênico quimérico a cd33 BR112017001242A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2014082589 2014-07-21
CN2014090504 2014-11-06
PCT/US2015/041390 WO2016014576A1 (en) 2014-07-21 2015-07-21 Treatment of cancer using a cd33 chimeric antigen receptor

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BR112017001242A2 true BR112017001242A2 (pt) 2017-12-05

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EP (2) EP3722316A1 (pt)
JP (2) JP6831777B2 (pt)
KR (1) KR102594343B1 (pt)
CN (2) CN112481283A (pt)
AU (2) AU2015292755B2 (pt)
BR (1) BR112017001242A2 (pt)
CA (1) CA2955154C (pt)
CO (1) CO2017000510A2 (pt)
ES (1) ES2805475T3 (pt)
IL (1) IL250138B (pt)
MX (1) MX2017001008A (pt)
RU (1) RU2747384C2 (pt)
SG (2) SG10201913765YA (pt)
TW (1) TWI719942B (pt)
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