BR112017000939A2 - tratamento de câncer usando um receptor antigênico quimérico de cll-1 - Google Patents

tratamento de câncer usando um receptor antigênico quimérico de cll-1

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Publication number
BR112017000939A2
BR112017000939A2 BR112017000939A BR112017000939A BR112017000939A2 BR 112017000939 A2 BR112017000939 A2 BR 112017000939A2 BR 112017000939 A BR112017000939 A BR 112017000939A BR 112017000939 A BR112017000939 A BR 112017000939A BR 112017000939 A2 BR112017000939 A2 BR 112017000939A2
Authority
BR
Brazil
Prior art keywords
cll
antigen receptor
cancer treatment
chimeric antigen
car
Prior art date
Application number
BR112017000939A
Other languages
English (en)
Inventor
Richardson Celeste
Glass David
Ebersbach Hilmar
Brogdon Jennifer
Zhang Jiquan
Mannick Joan
Jascur Julia
Wei Lai
Murphy Leon
C Milone Michael
Wu Qilong
Yang Qiumei
Singh Reshma
Kenderian Saad
Gill Saar
Original Assignee
Novartis Ag
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Univ Pennsylvania filed Critical Novartis Ag
Publication of BR112017000939A2 publication Critical patent/BR112017000939A2/pt

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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Abstract

a invenção fornece composições e métodos para o tratamento de doenças associadas à expressão de cll-1. a invenção também se refere ao receptor antigênico quimérico (car) específico para cll-1, vetores que codificam o mesmo e células recombinantes que compreendem o car de cll-1. a invenção também inclui métodos de administração de uma célula geneticamente modificada que expressa um car que compreende um domínio de ligação a cll-1.
BR112017000939A 2014-07-21 2015-07-21 tratamento de câncer usando um receptor antigênico quimérico de cll-1 BR112017000939A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2014082602 2014-07-21
CN2014090500 2014-11-06
PCT/US2015/041337 WO2016014535A1 (en) 2014-07-21 2015-07-21 Treatment of cancer using a cll-1 chimeric antigen receptor

Publications (1)

Publication Number Publication Date
BR112017000939A2 true BR112017000939A2 (pt) 2017-11-14

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BR112017000939A BR112017000939A2 (pt) 2014-07-21 2015-07-21 tratamento de câncer usando um receptor antigênico quimérico de cll-1

Country Status (16)

Country Link
US (2) US10568947B2 (pt)
EP (1) EP3171882A1 (pt)
JP (2) JP6736540B2 (pt)
KR (1) KR20170037625A (pt)
CN (1) CN107109420A (pt)
AR (1) AR101829A1 (pt)
AU (2) AU2015292811B2 (pt)
BR (1) BR112017000939A2 (pt)
CA (1) CA2955465A1 (pt)
CO (1) CO2017000506A2 (pt)
IL (1) IL250116B (pt)
MX (1) MX2017001013A (pt)
RU (1) RU2741120C2 (pt)
SG (2) SG11201700418VA (pt)
TW (1) TWI718992B (pt)
WO (1) WO2016014535A1 (pt)

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