BR112017001183A2 - tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado - Google Patents

tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado

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Publication number
BR112017001183A2
BR112017001183A2 BR112017001183A BR112017001183A BR112017001183A2 BR 112017001183 A2 BR112017001183 A2 BR 112017001183A2 BR 112017001183 A BR112017001183 A BR 112017001183A BR 112017001183 A BR112017001183 A BR 112017001183A BR 112017001183 A2 BR112017001183 A2 BR 112017001183A2
Authority
BR
Brazil
Prior art keywords
bcma
chimeric antigen
cancer treatment
antigen receptor
humanized anti
Prior art date
Application number
BR112017001183A
Other languages
English (en)
Inventor
H June Carl
Richardson Celeste
Glass David
Choi Eugene
Plesa Gabriela
Huet Heather
Ebersbach Hilmar
Brogdon Jennifer
Mannick Joan
Murphy Leon
Ruella Marco
C Milone Michael
Wu Qilong
Singh Reshma
Wang Yongqiang
Original Assignee
Novartis Ag
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Univ Pennsylvania filed Critical Novartis Ag
Publication of BR112017001183A2 publication Critical patent/BR112017001183A2/pt

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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Abstract

a presente invenção refere-se a composições e métodos para tratamento de doenças associadas com expressão de bcma. a invenção refere-se também a receptor de antígeno quimérico (car) específico para vetores de bcma codificando o mesmo e células t recombinantes compreendendo o bcma car. a invenção inclui também métodos de administração de uma célula t geneticamente modificada expressando um car que compreende um domínio de ligação de bcma.
BR112017001183A 2014-07-21 2015-07-21 tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado BR112017001183A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2014082586 2014-07-21
CN2014090501 2014-11-06
PCT/US2015/041378 WO2016014565A2 (en) 2014-07-21 2015-07-21 Treatment of cancer using humanized anti-bcma chimeric antigen receptor

Publications (1)

Publication Number Publication Date
BR112017001183A2 true BR112017001183A2 (pt) 2017-11-28

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BR112017001183A BR112017001183A2 (pt) 2014-07-21 2015-07-21 tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado

Country Status (16)

Country Link
US (3) US10174095B2 (pt)
EP (1) EP3172237A2 (pt)
JP (2) JP7054622B2 (pt)
KR (1) KR102612313B1 (pt)
CN (1) CN106687483B (pt)
AU (2) AU2015292744C1 (pt)
BR (1) BR112017001183A2 (pt)
CA (1) CA2955386A1 (pt)
CO (1) CO2017000507A2 (pt)
IL (1) IL250043B (pt)
MX (1) MX2017001011A (pt)
MY (1) MY181834A (pt)
RU (1) RU2751660C2 (pt)
SG (1) SG11201700476VA (pt)
TW (1) TWI750110B (pt)
WO (1) WO2016014565A2 (pt)

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