DE69309472T2 - Fusionsproteine von monomeren und dimeren von antikörperfragmenten - Google Patents

Fusionsproteine von monomeren und dimeren von antikörperfragmenten

Info

Publication number
DE69309472T2
DE69309472T2 DE69309472T DE69309472T DE69309472T2 DE 69309472 T2 DE69309472 T2 DE 69309472T2 DE 69309472 T DE69309472 T DE 69309472T DE 69309472 T DE69309472 T DE 69309472T DE 69309472 T2 DE69309472 T2 DE 69309472T2
Authority
DE
Germany
Prior art keywords
pct
fusion proteins
antibody
dimers
monomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69309472T
Other languages
English (en)
Other versions
DE69309472D1 (de
Inventor
Andreas Plueckthun
Peter Pack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of DE69309472D1 publication Critical patent/DE69309472D1/de
Publication of DE69309472T2 publication Critical patent/DE69309472T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
DE69309472T 1992-01-23 1993-01-15 Fusionsproteine von monomeren und dimeren von antikörperfragmenten Expired - Lifetime DE69309472T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92101069 1992-01-23
PCT/EP1993/000082 WO1993015210A1 (en) 1992-01-23 1993-01-15 Monomeric and dimeric antibody-fragment fusion proteins

Publications (2)

Publication Number Publication Date
DE69309472D1 DE69309472D1 (de) 1997-05-07
DE69309472T2 true DE69309472T2 (de) 1997-10-23

Family

ID=8209260

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69309472T Expired - Lifetime DE69309472T2 (de) 1992-01-23 1993-01-15 Fusionsproteine von monomeren und dimeren von antikörperfragmenten

Country Status (16)

Country Link
US (1) US5910573A (de)
EP (1) EP0654085B1 (de)
JP (2) JP3490437B2 (de)
KR (1) KR100254759B1 (de)
AT (1) ATE151113T1 (de)
AU (1) AU676150B2 (de)
CA (1) CA2128511C (de)
CZ (1) CZ287296B6 (de)
DE (1) DE69309472T2 (de)
DK (1) DK0654085T3 (de)
ES (1) ES2102007T3 (de)
GR (1) GR3023860T3 (de)
HU (1) HU215180B (de)
NO (1) NO942750L (de)
RU (1) RU2128709C1 (de)
WO (1) WO1993015210A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10133071A1 (de) * 2001-07-07 2003-03-06 Alexander Cherkasky Antigene, Rezeptoren, Liganden oder ihre Regionen kombiniert mit proteolytischer Aktivität

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HU215180B (hu) 1998-10-28
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