HUP0003513A2 - Apoptózist indukáló monoklonális antitest - Google Patents

Apoptózist indukáló monoklonális antitest

Info

Publication number
HUP0003513A2
HUP0003513A2 HU0003513A HUP0003513A HUP0003513A2 HU P0003513 A2 HUP0003513 A2 HU P0003513A2 HU 0003513 A HU0003513 A HU 0003513A HU P0003513 A HUP0003513 A HU P0003513A HU P0003513 A2 HUP0003513 A2 HU P0003513A2
Authority
HU
Hungary
Prior art keywords
inducing apoptosis
subject
monoclonal antibodies
monoclonal antibody
antibodies according
Prior art date
Application number
HU0003513A
Other languages
English (en)
Inventor
Naoshi Fukushima
Shinsuke Uno
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Publication of HUP0003513A2 publication Critical patent/HUP0003513A2/hu
Publication of HUP0003513A3 publication Critical patent/HUP0003513A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Abstract

A találmány tárgyát monoklonális antitestek képezik, amelyek képesekintegrinasszociált fehérjéket (Integrin Associated Proteins, IAP)tartalmazó, sejtmaggal rendelkező vérsejtek apoptózisát indukálni; atalálmány tárgyát képezik továbbá a találmány szerinti monoklonálisantitestek fragmensei, peptidjei és kis molekulatömegű vegyületei; atalálmány tárgyát képezik a találmány szerinti monoklonálisantitesteket termelő hibridómák is. A találmány szerinti antitestekterápiás ágensként alkalmazhatók mieloid leukémia és limfoid leukémiaesetében. Ó
HU0003513A 1997-09-11 1998-09-11 Monoclonal antibody inducing apoptosis HUP0003513A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP26485397 1997-09-11

Publications (2)

Publication Number Publication Date
HUP0003513A2 true HUP0003513A2 (hu) 2001-02-28
HUP0003513A3 HUP0003513A3 (en) 2004-05-28

Family

ID=17409137

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003513A HUP0003513A3 (en) 1997-09-11 1998-09-11 Monoclonal antibody inducing apoptosis

Country Status (14)

Country Link
US (1) US20030157100A1 (hu)
EP (1) EP1035132B1 (hu)
KR (2) KR20040106585A (hu)
CN (1) CN1198845C (hu)
AT (1) ATE395362T1 (hu)
AU (1) AU740225B2 (hu)
CA (1) CA2303072A1 (hu)
DE (1) DE69839492D1 (hu)
HU (1) HUP0003513A3 (hu)
NO (1) NO20001238L (hu)
PL (1) PL339265A1 (hu)
RU (1) RU2212413C2 (hu)
SK (1) SK3232000A3 (hu)
WO (1) WO1999012973A1 (hu)

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WO1995006748A1 (fr) * 1993-09-03 1995-03-09 Chugai Seiyaku Kabushiki Kaisha Anticorps monoclonal permettant d'induire une apoptose
US7531643B2 (en) 1997-09-11 2009-05-12 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody inducing apoptosis
US7696325B2 (en) 1999-03-10 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Polypeptide inducing apoptosis
WO2000053634A1 (fr) * 1999-03-10 2000-09-14 Chugai Seiyaku Kabushiki Kaisha Fv monocatenaire induisant l'apoptose
TWI241345B (en) * 2000-03-10 2005-10-11 Chugai Pharmaceutical Co Ltd Apoptosis inducing polypeptide
AU2001246934A1 (en) * 2000-04-17 2001-10-30 Chugai Seiyaku Kabushiki Kaisha Agonist antibodies
US20040058393A1 (en) * 2000-04-17 2004-03-25 Naoshi Fukishima Agonist antibodies
KR100870123B1 (ko) * 2000-10-20 2008-11-25 츄가이 세이야꾸 가부시키가이샤 저분자화 아고니스트 항체
WO2002033072A1 (en) * 2000-10-20 2002-04-25 Chugai Seiyaku Kabushiki Kaisha Degraded tpo agonist antibody
KR20030055274A (ko) 2000-10-20 2003-07-02 츄가이 세이야꾸 가부시키가이샤 저분자화 트롬보포에틴 아고니스트 항체
WO2002033073A1 (fr) * 2000-10-20 2002-04-25 Chugai Seiyaku Kabushiki Kaisha Anticorps agoniste degrade
US20050069549A1 (en) 2002-01-14 2005-03-31 William Herman Targeted ligands
DE60324700D1 (de) 2002-10-11 2008-12-24 Chugai Pharmaceutical Co Ltd Zelltod-induzierender wirkstoff
JP2004279086A (ja) 2003-03-13 2004-10-07 Konica Minolta Holdings Inc 放射線画像変換パネル及び放射線画像変換パネルの製造方法
EP1609803A4 (en) * 2003-03-31 2006-05-24 Chugai Pharmaceutical Co Ltd MODIFIED ANTIBODY AGAINST CD22 AND ITS USE
US8613922B2 (en) 2003-04-24 2013-12-24 The University Of North Carolina At Chapel Hill Methods for inhibiting diabetic retinopathy with an antibody against integrin associated protein (IAP)
US8101719B2 (en) 2003-11-11 2012-01-24 Chugai Seiyaku Kabushiki Kaisha Humanized anti-CD47 antibody
TW200530269A (en) 2003-12-12 2005-09-16 Chugai Pharmaceutical Co Ltd Anti-Mpl antibodies
WO2005056603A1 (ja) * 2003-12-12 2005-06-23 Chugai Seiyaku Kabushiki Kaisha 細胞死誘導剤
TW200530266A (en) * 2003-12-12 2005-09-16 Chugai Pharmaceutical Co Ltd Method of reinforcing antibody activity
JPWO2005056602A1 (ja) * 2003-12-12 2008-03-06 中外製薬株式会社 アゴニスト活性を有する改変抗体のスクリーニング方法
TW200722518A (en) 2005-03-31 2007-06-16 Chugai Pharmaceutical Co Ltd Sc(fv)2 structural isomers
US20090022687A1 (en) * 2005-05-18 2009-01-22 Chugai Seiyaku Kabushiki Kaisha Novel Pharmaceuticals That Use Anti-HLA Antibodies
AU2006256041B2 (en) 2005-06-10 2012-03-29 Chugai Seiyaku Kabushiki Kaisha Stabilizer for protein preparation comprising meglumine and use thereof
JP5085322B2 (ja) 2005-06-10 2012-11-28 中外製薬株式会社 ｓｃ（Ｆｖ）２を含有する医薬組成物
US20070113297A1 (en) * 2005-09-13 2007-05-17 Yongguang Yang Methods and compositions for inhibition of immune responses
JPWO2008007755A1 (ja) * 2006-07-13 2009-12-10 中外製薬株式会社 細胞死誘導剤
CL2008000719A1 (es) * 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
CA3054220C (en) 2008-01-15 2022-10-11 The Board Of Trustees Of The Leland Stanford Junior University Methods for manilpulating phagocytosis mediated by cd47
CA2711370C (en) 2008-01-15 2017-06-13 The Board Of Trustees Of The Leland Stanford Junior University Markers of acute myeloid leukemia stem cells
AU2009279676C1 (en) 2008-08-07 2015-08-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Radioprotectants targeting thrombospondin-1 and CD47
MX360772B (es) * 2012-02-06 2018-11-15 Inhibrx Inc Anticuerpos cd47 y metodos de uso de los mismos.
BR112015013431A2 (pt) 2012-12-12 2017-11-14 Vasculox Inc anticorpos monoclonais ou respectivos fragmentos ligantes de antígenos, composição farmacêutica, e usos de anticorpo monoclonal ou respectivo fragmento ligante de antígenos
US9221908B2 (en) 2012-12-12 2015-12-29 Vasculox, Inc. Therapeutic CD47 antibodies
RU2748401C2 (ru) 2015-09-18 2021-05-25 Арч Онколоджи, Инк. Терапевтические антитела к CD47
WO2018075960A1 (en) 2016-10-21 2018-04-26 Tioma Therapeutics, Inc. Therapeutic cd47 antibodies
TWI831759B (zh) 2017-12-01 2024-02-11 美商思進公司 Cd47抗體及其用於治療癌症之用途
CN110066336B (zh) * 2019-05-12 2021-11-09 杭州科兴生物科技有限公司 抗cd47单克隆抗体、片段及其医药用途
US20230181644A1 (en) 2021-10-28 2023-06-15 Lyell Immunopharma, Inc. Methods of generating cells
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0672142T3 (da) * 1992-12-04 2001-06-18 Medical Res Council Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse
WO1995006748A1 (fr) * 1993-09-03 1995-03-09 Chugai Seiyaku Kabushiki Kaisha Anticorps monoclonal permettant d'induire une apoptose
US6719972B1 (en) * 1994-06-03 2004-04-13 Repligen Corporation Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies
US5885574A (en) * 1994-07-26 1999-03-23 Amgen Inc. Antibodies which activate an erythropoietin receptor
WO1997032601A1 (fr) * 1996-03-06 1997-09-12 Chugai Seiyaku Kabushiki Kaisha Procede de criblage de substances induisant l'apoptose
US7531643B2 (en) * 1997-09-11 2009-05-12 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody inducing apoptosis
US7696325B2 (en) * 1999-03-10 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Polypeptide inducing apoptosis

Also Published As

Publication number Publication date
HUP0003513A3 (en) 2004-05-28
EP1035132B1 (en) 2008-05-14
KR20010023866A (ko) 2001-03-26
RU2212413C2 (ru) 2003-09-20
AU9002898A (en) 1999-03-29
KR20040106585A (ko) 2004-12-17
WO1999012973A1 (fr) 1999-03-18
PL339265A1 (en) 2000-12-04
CN1276798A (zh) 2000-12-13
EP1035132A4 (en) 2005-02-09
SK3232000A3 (en) 2000-09-12
NO20001238D0 (no) 2000-03-09
CN1198845C (zh) 2005-04-27
NO20001238L (no) 2000-05-11
EP1035132A1 (en) 2000-09-13
ATE395362T1 (de) 2008-05-15
CA2303072A1 (en) 1999-03-18
US20030157100A1 (en) 2003-08-21
DE69839492D1 (de) 2008-06-26
AU740225B2 (en) 2001-11-01

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees