DE60324700D1 - Zelltod-induzierender wirkstoff - Google Patents

Zelltod-induzierender wirkstoff

Info

Publication number
DE60324700D1
DE60324700D1 DE60324700T DE60324700T DE60324700D1 DE 60324700 D1 DE60324700 D1 DE 60324700D1 DE 60324700 T DE60324700 T DE 60324700T DE 60324700 T DE60324700 T DE 60324700T DE 60324700 D1 DE60324700 D1 DE 60324700D1
Authority
DE
Germany
Prior art keywords
antibody
cell
tod
active substance
cell death
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60324700T
Other languages
English (en)
Inventor
Shuji Ozaki
Masahiro Abe
Masayuki Tsuchiya
Naoki Kimura
Shigeto Kawai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE60324700D1 publication Critical patent/DE60324700D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
DE60324700T 2002-10-11 2003-10-10 Zelltod-induzierender wirkstoff Expired - Lifetime DE60324700D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002299289 2002-10-11
PCT/JP2003/013063 WO2004033499A1 (ja) 2002-10-11 2003-10-10 細胞死誘導剤

Publications (1)

Publication Number Publication Date
DE60324700D1 true DE60324700D1 (de) 2008-12-24

Family

ID=32089339

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60324700T Expired - Lifetime DE60324700D1 (de) 2002-10-11 2003-10-10 Zelltod-induzierender wirkstoff

Country Status (7)

Country Link
US (1) US8158385B2 (de)
EP (1) EP1561759B9 (de)
JP (2) JPWO2004033499A1 (de)
AT (1) ATE414105T1 (de)
AU (1) AU2003271175A1 (de)
DE (1) DE60324700D1 (de)
WO (1) WO2004033499A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696325B2 (en) 1999-03-10 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Polypeptide inducing apoptosis
CN1308447C (zh) * 2000-10-20 2007-04-04 中外制药株式会社 低分子化的激动剂抗体
CN1308448C (zh) 2000-10-20 2007-04-04 中外制药株式会社 低分子化的tpo激动剂抗体
DE60324700D1 (de) 2002-10-11 2008-12-24 Chugai Pharmaceutical Co Ltd Zelltod-induzierender wirkstoff
JP2004279086A (ja) * 2003-03-13 2004-10-07 Konica Minolta Holdings Inc 放射線画像変換パネル及び放射線画像変換パネルの製造方法
JPWO2004087763A1 (ja) * 2003-03-31 2006-07-27 中外製薬株式会社 Ｃｄ２２に対する改変抗体およびその利用
WO2005056602A1 (ja) * 2003-12-12 2005-06-23 Chugai Seiyaku Kabushiki Kaisha アゴニスト活性を有する改変抗体のスクリーニング方法
EP1710255A4 (de) * 2003-12-12 2008-09-24 Chugai Pharmaceutical Co Ltd Modifizierte antikörper, die rezeptortrimere oder höhere multimere erkennen
TW200530269A (en) 2003-12-12 2005-09-16 Chugai Pharmaceutical Co Ltd Anti-Mpl antibodies
EP1712565A4 (de) * 2003-12-12 2009-03-11 Chugai Pharmaceutical Co Ltd Den zelltod induzierende mittel
JP4799405B2 (ja) * 2004-04-09 2011-10-26 中外製薬株式会社 細胞死誘導剤
TW200722518A (en) * 2005-03-31 2007-06-16 Chugai Pharmaceutical Co Ltd Sc(fv)2 structural isomers
KR101374454B1 (ko) 2005-03-31 2014-03-17 추가이 세이야쿠 가부시키가이샤 회합제어에 의한 폴리펩티드 제조방법
EP1927367A4 (de) * 2005-05-18 2009-08-12 Univ Tokushima Neues pharmazeutisches mittel mit anti-hla-antikörper
JP5085322B2 (ja) 2005-06-10 2012-11-28 中外製薬株式会社 ｓｃ（Ｆｖ）２を含有する医薬組成物
US20090028854A1 (en) * 2005-06-10 2009-01-29 Chugai Seiyaku Kabushiki Kaisha sc(Fv)2 SITE-DIRECTED MUTANT
JP5068167B2 (ja) 2005-06-10 2012-11-07 中外製薬株式会社 メグルミンを含有するタンパク質製剤の安定化剤、およびその利用
EP2009101B1 (de) 2006-03-31 2017-10-25 Chugai Seiyaku Kabushiki Kaisha Antikörpermodifikationsverfahren für die aufreinigung eines bispezifischen antikörpers
AU2007273507A1 (en) 2006-07-13 2008-01-17 Chugai Seiyaku Kabushiki Kaisha Cell death inducer
CL2008000719A1 (es) 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
US20110117602A1 (en) * 2007-11-19 2011-05-19 Kagoshima University, Human antibody capable of inducing apoptosis
TW201118166A (en) * 2009-09-24 2011-06-01 Chugai Pharmaceutical Co Ltd HLA class I-recognizing antibodies
NO2802607T3 (de) 2012-01-13 2018-03-03
UA114108C2 (uk) 2012-07-10 2017-04-25 Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання
JP6534615B2 (ja) 2013-09-27 2019-06-26 中外製薬株式会社 ポリペプチド異種多量体の製造方法
EP3398965A4 (de) 2015-12-28 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Verfahren zur förderung der effizienz der reinigung von polypeptid mit fc-region

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
JP2727112B2 (ja) 1988-04-26 1998-03-11 コニカ株式会社 安定なペルオキシダーゼ組成物及び安定な抗体組成物
US5077216A (en) 1988-07-06 1991-12-31 The Trustees Of Dartmouth College Monoclonal antibodies specific for a human mononculear phagocyte-specific antigen
JPH0341033A (ja) 1989-07-07 1991-02-21 Kyowa Hakko Kogyo Co Ltd 安定なモチリン類含有製剤
US5223241A (en) 1990-10-01 1993-06-29 The General Hospital Corporation Method for early detection of allograft rejection
CA2097932A1 (en) 1991-10-11 1993-04-12 Shojiro Yamazaki Antibody containing composition
US5837821A (en) 1992-11-04 1998-11-17 City Of Hope Antibody construct
JP3720353B2 (ja) 1992-12-04 2005-11-24 メディカル リサーチ カウンシル 多価および多重特異性の結合タンパク質、それらの製造および使用
ATE187494T1 (de) 1992-12-11 1999-12-15 Dow Chemical Co Multivalente einkettige antikörper
US5780021A (en) 1993-03-05 1998-07-14 Georgetown University Method for treating type 1 diabetes using α-interferon and/or β-i
US5747654A (en) * 1993-06-14 1998-05-05 The United States Of America As Represented By The Department Of Health And Human Services Recombinant disulfide-stabilized polypeptide fragments having binding specificity
US5840344A (en) 1993-09-03 1998-11-24 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibodies having property of causing apoptosis
JP3554355B2 (ja) 1994-03-03 2004-08-18 中外製薬株式会社 Ｉｌ−６オートクライン増殖性ヒト骨髄腫細胞株
US6719972B1 (en) 1994-06-03 2004-04-13 Repligen Corporation Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies
US5885574A (en) 1994-07-26 1999-03-23 Amgen Inc. Antibodies which activate an erythropoietin receptor
DE69534530T2 (de) 1994-08-12 2006-07-06 Immunomedics, Inc. Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper
US8771694B2 (en) 1994-08-12 2014-07-08 Immunomedics, Inc. Immunoconjugates and humanized antibodies specific for B-cell lymphoma and leukemia cells
US6451523B1 (en) 1994-09-14 2002-09-17 Interneuron Pharmaceuticals, Inc. Detection of a leptin receptor variant and methods for regulating obesity
US5690935A (en) 1995-01-13 1997-11-25 Regents Of The University Of Minnesota Biotherapy of cancer by targeting TP-3/P80
DK0812136T3 (da) 1995-02-28 2001-02-19 Procter & Gamble Fremgangsmåde til fremstilling af ikke-kulsyreholdige læskedrikke med bedre mikrobiel stabilitet
US6013067A (en) 1995-06-07 2000-01-11 Zymogenetics, Inc. Methods for increasing hematopoietic cells
AU6113396A (en) 1995-06-14 1997-01-15 Regents Of The University Of California, The Novel high affinity human antibodies to tumor antigens
EP1619250B1 (de) 1996-01-08 2009-11-25 Genentech, Inc. OB Rezeptor-Variante und Liganden
FR2745008A1 (fr) 1996-02-20 1997-08-22 Ass Pour Le Dev De La Rech En Recepteur nucleaire de glucocorticoides modifie, fragments d'adn codant pour ledit recepteur et procedes dans lesquels ils sont mis en oeuvre
US6579692B1 (en) 1996-03-06 2003-06-17 Chugai Seiyaku Kabushiki Kaisha Method of screening apoptosis inducing substances
NZ332689A (en) 1996-05-09 2000-07-28 Pharma Pacific Pty Ltd Using interferon to treat autoimmune, mycobacterial or neurodegenerative disease
EP0852951A1 (de) 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
US6323000B2 (en) 1996-12-20 2001-11-27 Clark A. Briggs Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof
US6183744B1 (en) 1997-03-24 2001-02-06 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
US6306393B1 (en) 1997-03-24 2001-10-23 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
AU8296098A (en) 1997-07-08 1999-02-08 Board Of Regents, The University Of Texas System Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
US7531643B2 (en) 1997-09-11 2009-05-12 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody inducing apoptosis
HUP0003513A3 (en) 1997-09-11 2004-05-28 Chugai Pharmaceutical Co Ltd Monoclonal antibody inducing apoptosis
US7081360B2 (en) 1998-07-28 2006-07-25 Cadus Technologies, Inc. Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties
US20050220787A1 (en) 2002-11-07 2005-10-06 Lobo Peter I Naturally occuring IgM antibodies that bind to lymphocytes
US7696325B2 (en) 1999-03-10 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Polypeptide inducing apoptosis
US7442776B2 (en) 1999-10-08 2008-10-28 Young David S F Cancerous disease modifying antibodies
US20020028178A1 (en) 2000-07-12 2002-03-07 Nabil Hanna Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications
TWI242043B (en) 2000-03-10 2005-10-21 Chugai Pharmaceutical Co Ltd Polypeptide inducing apoptosis
US20040058393A1 (en) 2000-04-17 2004-03-25 Naoshi Fukishima Agonist antibodies
WO2002013860A1 (fr) 2000-08-11 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Preparations stabilisees contenant un anticorps
CN1308447C (zh) 2000-10-20 2007-04-04 中外制药株式会社 低分子化的激动剂抗体
CN1308448C (zh) 2000-10-20 2007-04-04 中外制药株式会社 低分子化的tpo激动剂抗体
CA2424371A1 (en) 2000-10-20 2003-04-01 Chugai Seiyaku Kabushiki Kaisha Agonistic monoclonal antibody fragments
CA2424364A1 (en) 2000-10-20 2003-04-01 Chugai Seiyaku Kabushiki Kaisha Degraded tpo agonist antibody
CA2447602C (en) 2001-05-18 2011-11-01 Kirin Beer Kabushiki Kaisha Anti-trail-r antibodies
US7321026B2 (en) 2001-06-27 2008-01-22 Skytech Technology Limited Framework-patched immunoglobulins
US20030148409A1 (en) 2001-10-15 2003-08-07 Edmund Rossi Direct targeting binding proteins
JP3665324B2 (ja) 2001-10-15 2005-06-29 麒麟麦酒株式会社 抗ｈｌａ−ｄｒ抗体
EP3192528A1 (de) 2002-02-14 2017-07-19 Chugai Seiyaku Kabushiki Kaisha Formularierung anti-il-6r antikörper-enthaltender lösungen die einen zucker als stabilisator beinhalten
DE60334364D1 (de) 2002-02-21 2010-11-11 Univ California Behandlungsverfahren unter verwendung von anti-cd22-antikörpern
WO2003087163A1 (fr) 2002-04-15 2003-10-23 Chugai Seiyaku Kabushiki Kaisha Procede d'elaboration d'une banque scdb
JP2004086862A (ja) 2002-05-31 2004-03-18 Celestar Lexico-Sciences Inc タンパク質相互作用情報処理装置、タンパク質相互作用情報処理方法、プログラム、および、記録媒体
WO2003107218A1 (ja) 2002-05-31 2003-12-24 セレスター・レキシコ・サイエンシズ株式会社 相互作用予測装置
EP1551453A4 (de) 2002-06-17 2007-04-25 Us Gov Health & Human Serv Spezifitätsgrafting eines mäuseantikörpers auf ein menschliches gerüst
JP2005529616A (ja) 2002-06-18 2005-10-06 アイアールエム エルエルシー 化学療法耐性腫瘍の診断および治療
AU2003246102A1 (en) 2002-06-27 2004-01-19 Genox Research, Inc. Method of examining allergic disease and drug for treating the same
WO2005004912A1 (en) 2003-07-11 2005-01-20 Oncotherapy Science, Inc. Method for treating synovial sarcoma
DE60324700D1 (de) 2002-10-11 2008-12-24 Chugai Pharmaceutical Co Ltd Zelltod-induzierender wirkstoff
JPWO2004037293A1 (ja) 2002-10-22 2006-02-23 大日本住友製薬株式会社 安定化組成物
JP2004279086A (ja) 2003-03-13 2004-10-07 Konica Minolta Holdings Inc 放射線画像変換パネル及び放射線画像変換パネルの製造方法
JPWO2004087763A1 (ja) 2003-03-31 2006-07-27 中外製薬株式会社 Ｃｄ２２に対する改変抗体およびその利用
WO2005044857A1 (ja) 2003-11-11 2005-05-19 Chugai Seiyaku Kabushiki Kaisha ヒト化抗cd47抗体
WO2005056602A1 (ja) 2003-12-12 2005-06-23 Chugai Seiyaku Kabushiki Kaisha アゴニスト活性を有する改変抗体のスクリーニング方法
EP1710255A4 (de) 2003-12-12 2008-09-24 Chugai Pharmaceutical Co Ltd Modifizierte antikörper, die rezeptortrimere oder höhere multimere erkennen
EP1712565A4 (de) 2003-12-12 2009-03-11 Chugai Pharmaceutical Co Ltd Den zelltod induzierende mittel
TW200530266A (en) 2003-12-12 2005-09-16 Chugai Pharmaceutical Co Ltd Method of reinforcing antibody activity
TW200530269A (en) 2003-12-12 2005-09-16 Chugai Pharmaceutical Co Ltd Anti-Mpl antibodies
KR20070010046A (ko) 2004-04-06 2007-01-19 제넨테크, 인크. Ｄｒ5 항체 및 그의 용도
JP4799405B2 (ja) 2004-04-09 2011-10-26 中外製薬株式会社 細胞死誘導剤
TW200722518A (en) 2005-03-31 2007-06-16 Chugai Pharmaceutical Co Ltd Sc(fv)2 structural isomers
EP1927367A4 (de) 2005-05-18 2009-08-12 Univ Tokushima Neues pharmazeutisches mittel mit anti-hla-antikörper
US20090028854A1 (en) 2005-06-10 2009-01-29 Chugai Seiyaku Kabushiki Kaisha sc(Fv)2 SITE-DIRECTED MUTANT
JP5068167B2 (ja) 2005-06-10 2012-11-07 中外製薬株式会社 メグルミンを含有するタンパク質製剤の安定化剤、およびその利用
RU2008135433A (ru) 2006-02-02 2010-03-10 Дзе Дженерал Хоспитал Корпорейшн (Us) Гибриды рекомбинантных антител-белков стресса
AU2007273507A1 (en) 2006-07-13 2008-01-17 Chugai Seiyaku Kabushiki Kaisha Cell death inducer
BRPI0713086A2 (pt) 2006-08-14 2012-10-09 Forerunner Pharma Res Co Ltd diagnóstico e tratamento de cáncer usando anticorpo anti-desmogleìna-3
CL2008000719A1 (es) 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
ES2511844T3 (es) 2007-12-21 2014-10-23 F. Hoffmann-La Roche Ag Formulación de anticuerpo

Also Published As

Publication number Publication date
JP2010155841A (ja) 2010-07-15
ATE414105T1 (de) 2008-11-15
EP1561759A1 (de) 2005-08-10
US20060275301A1 (en) 2006-12-07
EP1561759B1 (de) 2008-11-12
EP1561759B9 (de) 2009-08-26
EP1561759A4 (de) 2006-05-31
AU2003271175A1 (en) 2004-05-04
WO2004033499A1 (ja) 2004-04-22
US8158385B2 (en) 2012-04-17
JPWO2004033499A1 (ja) 2006-02-09

Similar Documents

Publication Publication Date Title
DE60324700D1 (de) Zelltod-induzierender wirkstoff
EA200300464A1 (ru) ГУМАНИЗИРОВАННОЕ АНТИТЕЛО ПРОТИВ РЕЦЕПТОРА ЛИМФОТОКСИНА-β (ВАРИАНТЫ), КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ИЛИ СНИЖЕНИЯ РИСКА РАЗВИТИЯ, ТЯЖЕСТИ ИЛИ ПОСЛЕДСТВИЙ НЕОПЛАЗИИ У ЧЕЛОВЕКА, ВЫДЕЛЕННАЯ НУКЛЕИНОВАЯ КИСЛОТА (ВАРИАНТЫ), КЛЕТКА КЛЕТОЧНОЙ ЛИНИИ
EA200401198A1 (ru) АНТИТЕЛА ПРОТИВ αvβ6
EA200500520A1 (ru) Пуриновые соединения и их применение в качестве лигандов каннабиноидных рецепторов
EA200600594A1 (ru) Новые гетероциклические соединения - ингибиторы hsp90 и способы их получения
PT1315520E (pt) Utilizacao de anticorpos trifuncionais biespecificos e triespecificos para tratamento de ascites malignas
EA200100315A1 (ru) Простые тетрагидропиридовые эфиры
EA200301117A1 (ru) Антитела против vla-1
CO5580797A2 (es) Anticuerpos anti-cd33 y metodo para tratamiento de leucemia mieloide aguda utilizando los mismos
ES2559763T3 (es) Anticuerpo humano específico de CD3 con propiedades inmunosupresoras
DE69433663D1 (de) Antikörper gegen menschliches prostatspezifisches drüsenkallikrein
EA200800812A1 (ru) Композиции антитела против cd3
EA200501286A1 (ru) МОЛЕКУЛЫ АНТИТЕЛ СО СПЕЦИФИЧНОСТЬЮ К ЧЕЛОВЕЧЕСКОМУ IL-1β
EA199900620A1 (ru) Фталазиноны
EA200201214A1 (ru) Замещенные тиоацетамиды
EA200800199A1 (ru) Способ получения олефина и/или простого эфира
EA200970923A1 (ru) АНТИ-EpСАМ АНТИТЕЛО И ЕГО ПРИМЕНЕНИЕ
BRPI0509177A (pt) uso de anticorpos anti-alfa5beta1 para inibir a proliferação de células cancerìgenas
DE69932812D1 (de) Epitope in der viralen hüllproteine und spezifische antikörper gegen diese epitope: verwendung für die detektion von hcv viralantigene im empfängergewebe
MX2021002299A (es) Anticuerpos de anti-cd33 y metodos para usarlos.
EA200401628A1 (ru) Ингибиторы пептидной деформилазы
SE0000675D0 (sv) Monoclonal antibodies
ATE467128T1 (de) Kolloidale metallkonjugate
EA200200974A1 (ru) Моноклональные антитела к рецептору лпнп человека, их получение и применение
WO2003055908A3 (en) Bag3 nucleotide and protein sequences to be used in research, diagnostics and therapy for cell death-involving diseases

Legal Events

Date Code Title Description
8364 No opposition during term of opposition