DE69932812D1 - Epitope in der viralen hüllproteine und spezifische antikörper gegen diese epitope: verwendung für die detektion von hcv viralantigene im empfängergewebe - Google Patents

Epitope in der viralen hüllproteine und spezifische antikörper gegen diese epitope: verwendung für die detektion von hcv viralantigene im empfängergewebe

Info

Publication number
DE69932812D1
DE69932812D1 DE69932812T DE69932812T DE69932812D1 DE 69932812 D1 DE69932812 D1 DE 69932812D1 DE 69932812 T DE69932812 T DE 69932812T DE 69932812 T DE69932812 T DE 69932812T DE 69932812 D1 DE69932812 D1 DE 69932812D1
Authority
DE
Germany
Prior art keywords
epitopes
detection
proteins
viral
hcv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69932812T
Other languages
English (en)
Other versions
DE69932812T2 (de
Inventor
Geert Maertens
Erik Depla
Marie-Ange Buyse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujirebio Europe NV SA
Original Assignee
Innogenetics NV SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics NV SA filed Critical Innogenetics NV SA
Application granted granted Critical
Publication of DE69932812D1 publication Critical patent/DE69932812D1/de
Publication of DE69932812T2 publication Critical patent/DE69932812T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C07K16/109—Hepatitis C virus; Hepatitis G virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69932812T 1998-03-27 1999-03-29 Epitope in der viralen hüllproteine und spezifische antikörper gegen diese epitope: verwendung für die detektion von hcv viralantigene im empfängergewebe Expired - Fee Related DE69932812T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98870060 1998-03-27
EP98870060A EP0947525A1 (de) 1998-03-27 1998-03-27 Epitope in der viralen Hüllproteine und spezifische Antikörper gegen diese Epitope: Verwendung für die detektion von viralantigene im empfängergewebe
PCT/EP1999/002154 WO1999050301A2 (en) 1998-03-27 1999-03-29 Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of hcv viral antigen in host tissue

Publications (2)

Publication Number Publication Date
DE69932812D1 true DE69932812D1 (de) 2006-09-28
DE69932812T2 DE69932812T2 (de) 2007-04-12

Family

ID=8237012

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69932812T Expired - Fee Related DE69932812T2 (de) 1998-03-27 1999-03-29 Epitope in der viralen hüllproteine und spezifische antikörper gegen diese epitope: verwendung für die detektion von hcv viralantigene im empfängergewebe

Country Status (19)

Country Link
US (2) US6521403B1 (de)
EP (2) EP0947525A1 (de)
JP (1) JP3657515B2 (de)
KR (1) KR20010042225A (de)
CN (1) CN1294598A (de)
AT (1) ATE336512T1 (de)
AU (1) AU756495B2 (de)
BR (1) BR9909026A (de)
CA (1) CA2321179A1 (de)
DE (1) DE69932812T2 (de)
ES (1) ES2272065T3 (de)
HU (1) HUP0103650A3 (de)
IL (1) IL138586A0 (de)
NZ (1) NZ506553A (de)
PL (1) PL343638A1 (de)
PT (1) PT1064309E (de)
TR (1) TR200002695T2 (de)
WO (1) WO1999050301A2 (de)
ZA (1) ZA200004383B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69526636T3 (de) * 1994-07-29 2006-11-23 Innogenetics N.V. Gereinigte hepatitis-c-virus hüllproteine zur diagnostischen und therapeutischen verwendung
US20030180284A1 (en) * 1998-11-05 2003-09-25 Board Of Trustees Of Leland Stanford Junior University Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes
AU1144501A (en) * 1999-10-27 2001-05-08 Innogenetics N.V. Redox reversible hcv proteins with native-like conformation
EP1535628B1 (de) * 1999-11-24 2013-07-31 Novartis Vaccines and Diagnostics, Inc. Hbv/hcv virus-ähnliche teilchen
EP1178116A1 (de) * 2000-08-03 2002-02-06 Hybrigenics S.A. Sid nukleische Saüre und aus einem pathogenischen Stamm des Hepatitis C Viruses selektierte Polypeptide und deren Verwendungenthereof
US6924362B2 (en) * 2000-12-01 2005-08-02 The United States Of America As Represented By The Department Of Health & Human Services Monoclonal antibodies specific for the E2 glycoprotein of hepatitic C virus and their use in the diagnosis, treatment, and prevention of hepatitis C
WO2002060954A1 (en) 2001-01-12 2002-08-08 Karolinska Innovations Ab Materials and methods for treatment of hepatitis c
KR20060087574A (ko) * 2003-09-22 2006-08-02 가부시키가이샤 그린 펩티드 Ｃ형 간염 바이러스 유래 펩티드
EP1574517A1 (de) 2004-03-09 2005-09-14 Innogenetics N.V. HCV E1 beinhaltend spezifische Disulfidbrücken
EP1602664A1 (de) * 2004-03-08 2005-12-07 Innogenetics N.V. HCV E1 beinhaltend spezifische Disulfidbrücken
US7309589B2 (en) * 2004-08-20 2007-12-18 Vironix Llc Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing
WO2006033012A2 (en) * 2004-09-24 2006-03-30 Pfizer Limited Method of screening for modulators of hepatitis c virus infection
WO2008150282A1 (en) * 2006-02-23 2008-12-11 University Of California, San Diego Ribosomal s-6 kinase (rsk) inhibitory peptides and method of use thereof
US20090311248A1 (en) * 2006-03-22 2009-12-17 Erik Depla Hepatitis C Virus Neutralizing Antibodies
EP2030628B1 (de) * 2006-06-01 2012-08-15 Yun Cheng Peptid zur prophylaxe oder therapie von leberschäden sowie ein derivat davon und seine verwendung
US8551484B2 (en) 2007-02-21 2013-10-08 University Of Massachusetts Human antibodies against hepatitis C virus (HCV) and uses thereof
EP2336173A4 (de) 2008-09-30 2012-07-25 Toray Industries Zur bindung des hüllproteins 2 des hepatitis-c-virus fähiger antikörper und verfahren zur identifizierung des genotyps des hepatitis-c-virus unter dessen verwendung
US20100104555A1 (en) * 2008-10-24 2010-04-29 The Scripps Research Institute HCV neutralizing epitopes
US9751931B2 (en) 2012-10-26 2017-09-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hepatitis C virus neutralizing antibodies and methods
CN111795920B (zh) * 2015-03-23 2024-04-30 赛多利斯生物分析仪器股份有限公司 对生物材料评估腺病毒或腺相关病毒的病毒类型的非缔合的病毒尺寸颗粒
CN109160942B (zh) * 2018-09-26 2021-06-29 广州市第八人民医院 Hcv包膜蛋白高度保守区域的肽段502-518及其用途
CN109232722B (zh) * 2018-09-26 2021-06-29 广州市第八人民医院 Hcv包膜蛋白高度保守区域的肽段317-325及其用途
KR20230050761A (ko) 2021-10-08 2023-04-17 김민준 과제기한 자동알림

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308750A (en) 1989-12-22 1994-05-03 Abbott Laboratories Monoclonal antibodies to putative HCV E2/NS1 proteins and methods for using same
ES2139591T5 (es) 1990-11-08 2007-08-01 Novartis Vaccines And Diagnostics, Inc. Asialoglicoproteinas del virus de la hepatitis c.
AU662517B2 (en) * 1991-01-31 1995-09-07 Abbott Laboratories Monoclonal antibodies to putative HCV envelope region and methods for using same
FR2677372B1 (fr) 1991-06-06 1994-11-10 Pasteur Institut Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques.
DE4209215A1 (de) * 1991-07-04 1993-01-07 Boehringer Mannheim Gmbh Hcv peptidantigene und verfahren zur bestimmung von hcv
IT1249684B (it) 1991-07-19 1995-03-09 Sorin Biomedica Spa Epitopi della proteina env del virus dell'epatite c.
JP3439209B2 (ja) 1992-01-31 2003-08-25 アボツト・ラボラトリーズ Ｈｃｖ蛋白のための哺乳動物発現システム
AU671623B2 (en) * 1992-03-06 1996-09-05 N.V. Innogenetics S.A. Process for the determination of peptides corresponding to immunologically important epitopes and biotinylated peptides used therein
JPH05344899A (ja) 1992-06-11 1993-12-27 Kokuritsu Yobou Eisei Kenkyusho Ｃ型肝炎ウイルス外被タンパク質の産生法
CA2143823C (en) * 1992-08-27 2005-07-26 Alfio Comis Retro-, inverso - and retro-inverso synthetic peptide analogues
US5514539A (en) 1993-06-29 1996-05-07 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
US5610009A (en) 1994-01-28 1997-03-11 Abbott Laboratories Mammalian expression systems for hepatitis C virus envelope genes
DE69526636T3 (de) 1994-07-29 2006-11-23 Innogenetics N.V. Gereinigte hepatitis-c-virus hüllproteine zur diagnostischen und therapeutischen verwendung
US6110465A (en) * 1995-06-07 2000-08-29 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of isolates of hepatitis C virus and the use of reagents derived from these hypervariable sequences in diagnostic methods and vaccines

Also Published As

Publication number Publication date
BR9909026A (pt) 2000-12-05
EP1064309A2 (de) 2001-01-03
DE69932812T2 (de) 2007-04-12
AU756495B2 (en) 2003-01-16
NZ506553A (en) 2002-11-26
EP0947525A1 (de) 1999-10-06
US20030129746A1 (en) 2003-07-10
ATE336512T1 (de) 2006-09-15
CA2321179A1 (en) 1999-10-07
US6841353B2 (en) 2005-01-11
TR200002695T2 (tr) 2000-12-21
JP3657515B2 (ja) 2005-06-08
JP2002510038A (ja) 2002-04-02
US6521403B1 (en) 2003-02-18
HUP0103650A2 (hu) 2002-01-28
AU3602299A (en) 1999-10-18
CN1294598A (zh) 2001-05-09
ZA200004383B (en) 2003-01-28
KR20010042225A (ko) 2001-05-25
ES2272065T3 (es) 2007-04-16
WO1999050301A3 (en) 1999-11-25
IL138586A0 (en) 2001-10-31
PL343638A1 (en) 2001-08-27
WO1999050301A2 (en) 1999-10-07
EP1064309B1 (de) 2006-08-16
HUP0103650A3 (en) 2005-10-28
PT1064309E (pt) 2006-12-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee