ZA200004383B - Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue. - Google Patents

Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue.

Info

Publication number
ZA200004383B
ZA200004383B ZA200004383A ZA200004383A ZA200004383B ZA 200004383 B ZA200004383 B ZA 200004383B ZA 200004383 A ZA200004383 A ZA 200004383A ZA 200004383 A ZA200004383 A ZA 200004383A ZA 200004383 B ZA200004383 B ZA 200004383B
Authority
ZA
South Africa
Prior art keywords
epitopes
directed against
detection
antibodies directed
envelope proteins
Prior art date
Application number
ZA200004383A
Other languages
English (en)
Inventor
Geert Maertens
Erik Depla
Marie-Ange Buyse
Original Assignee
Innogenetics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics Nv filed Critical Innogenetics Nv
Publication of ZA200004383B publication Critical patent/ZA200004383B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C07K16/109—Hepatitis C virus; Hepatitis G virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA200004383A 1998-03-27 2000-08-24 Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue. ZA200004383B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98870060A EP0947525A1 (en) 1998-03-27 1998-03-27 Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue

Publications (1)

Publication Number Publication Date
ZA200004383B true ZA200004383B (en) 2003-01-28

Family

ID=8237012

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200004383A ZA200004383B (en) 1998-03-27 2000-08-24 Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue.

Country Status (19)

Country Link
US (2) US6521403B1 (xx)
EP (2) EP0947525A1 (xx)
JP (1) JP3657515B2 (xx)
KR (1) KR20010042225A (xx)
CN (1) CN1294598A (xx)
AT (1) ATE336512T1 (xx)
AU (1) AU756495B2 (xx)
BR (1) BR9909026A (xx)
CA (1) CA2321179A1 (xx)
DE (1) DE69932812T2 (xx)
ES (1) ES2272065T3 (xx)
HU (1) HUP0103650A3 (xx)
IL (1) IL138586A0 (xx)
NZ (1) NZ506553A (xx)
PL (1) PL343638A1 (xx)
PT (1) PT1064309E (xx)
TR (1) TR200002695T2 (xx)
WO (1) WO1999050301A2 (xx)
ZA (1) ZA200004383B (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69526636T3 (de) * 1994-07-29 2006-11-23 Innogenetics N.V. Gereinigte hepatitis-c-virus hüllproteine zur diagnostischen und therapeutischen verwendung
US20030180284A1 (en) * 1998-11-05 2003-09-25 Board Of Trustees Of Leland Stanford Junior University Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes
AU1144501A (en) * 1999-10-27 2001-05-08 Innogenetics N.V. Redox reversible hcv proteins with native-like conformation
EP1535628B1 (en) * 1999-11-24 2013-07-31 Novartis Vaccines and Diagnostics, Inc. Hbv/hcv virus-like particle
EP1178116A1 (en) * 2000-08-03 2002-02-06 Hybrigenics S.A. Sid nucleic acids and polypeptides selected from a pathogenic strain of hepatitis C virus and applications thereof
US6924362B2 (en) * 2000-12-01 2005-08-02 The United States Of America As Represented By The Department Of Health & Human Services Monoclonal antibodies specific for the E2 glycoprotein of hepatitic C virus and their use in the diagnosis, treatment, and prevention of hepatitis C
WO2002060954A1 (en) 2001-01-12 2002-08-08 Karolinska Innovations Ab Materials and methods for treatment of hepatitis c
KR20060087574A (ko) * 2003-09-22 2006-08-02 가부시키가이샤 그린 펩티드 Ｃ형 간염 바이러스 유래 펩티드
EP1574517A1 (en) 2004-03-09 2005-09-14 Innogenetics N.V. HCV E1 comprising specific disulfide bridges
EP1602664A1 (en) * 2004-03-08 2005-12-07 Innogenetics N.V. HCV E1 comprising specific disulfide bridges
US7309589B2 (en) * 2004-08-20 2007-12-18 Vironix Llc Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing
WO2006033012A2 (en) * 2004-09-24 2006-03-30 Pfizer Limited Method of screening for modulators of hepatitis c virus infection
WO2008150282A1 (en) * 2006-02-23 2008-12-11 University Of California, San Diego Ribosomal s-6 kinase (rsk) inhibitory peptides and method of use thereof
US20090311248A1 (en) * 2006-03-22 2009-12-17 Erik Depla Hepatitis C Virus Neutralizing Antibodies
EP2030628B1 (en) * 2006-06-01 2012-08-15 Yun Cheng A peptide for preventing or treating liver damage and its derivant and the use
US8551484B2 (en) 2007-02-21 2013-10-08 University Of Massachusetts Human antibodies against hepatitis C virus (HCV) and uses thereof
EP2336173A4 (en) 2008-09-30 2012-07-25 Toray Industries FOR BINDING THE CROP PROTEIN 2 OF THE HEPATITIS C-VIRUS CAPACITIVE ANTIBODY AND METHOD FOR IDENTIFYING THE GENOTYPIC OF THE HEPATITIS C VIRUS USING THEREOF
US20100104555A1 (en) * 2008-10-24 2010-04-29 The Scripps Research Institute HCV neutralizing epitopes
US9751931B2 (en) 2012-10-26 2017-09-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hepatitis C virus neutralizing antibodies and methods
CN111795920B (zh) * 2015-03-23 2024-04-30 赛多利斯生物分析仪器股份有限公司 对生物材料评估腺病毒或腺相关病毒的病毒类型的非缔合的病毒尺寸颗粒
CN109160942B (zh) * 2018-09-26 2021-06-29 广州市第八人民医院 Hcv包膜蛋白高度保守区域的肽段502-518及其用途
CN109232722B (zh) * 2018-09-26 2021-06-29 广州市第八人民医院 Hcv包膜蛋白高度保守区域的肽段317-325及其用途
KR20230050761A (ko) 2021-10-08 2023-04-17 김민준 과제기한 자동알림

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308750A (en) 1989-12-22 1994-05-03 Abbott Laboratories Monoclonal antibodies to putative HCV E2/NS1 proteins and methods for using same
ES2139591T5 (es) 1990-11-08 2007-08-01 Novartis Vaccines And Diagnostics, Inc. Asialoglicoproteinas del virus de la hepatitis c.
AU662517B2 (en) * 1991-01-31 1995-09-07 Abbott Laboratories Monoclonal antibodies to putative HCV envelope region and methods for using same
FR2677372B1 (fr) 1991-06-06 1994-11-10 Pasteur Institut Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques.
DE4209215A1 (de) * 1991-07-04 1993-01-07 Boehringer Mannheim Gmbh Hcv peptidantigene und verfahren zur bestimmung von hcv
IT1249684B (it) 1991-07-19 1995-03-09 Sorin Biomedica Spa Epitopi della proteina env del virus dell'epatite c.
JP3439209B2 (ja) 1992-01-31 2003-08-25 アボツト・ラボラトリーズ Ｈｃｖ蛋白のための哺乳動物発現システム
AU671623B2 (en) * 1992-03-06 1996-09-05 N.V. Innogenetics S.A. Process for the determination of peptides corresponding to immunologically important epitopes and biotinylated peptides used therein
JPH05344899A (ja) 1992-06-11 1993-12-27 Kokuritsu Yobou Eisei Kenkyusho Ｃ型肝炎ウイルス外被タンパク質の産生法
CA2143823C (en) * 1992-08-27 2005-07-26 Alfio Comis Retro-, inverso - and retro-inverso synthetic peptide analogues
US5514539A (en) 1993-06-29 1996-05-07 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
US5610009A (en) 1994-01-28 1997-03-11 Abbott Laboratories Mammalian expression systems for hepatitis C virus envelope genes
DE69526636T3 (de) 1994-07-29 2006-11-23 Innogenetics N.V. Gereinigte hepatitis-c-virus hüllproteine zur diagnostischen und therapeutischen verwendung
US6110465A (en) * 1995-06-07 2000-08-29 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of isolates of hepatitis C virus and the use of reagents derived from these hypervariable sequences in diagnostic methods and vaccines

Also Published As

Publication number Publication date
BR9909026A (pt) 2000-12-05
EP1064309A2 (en) 2001-01-03
DE69932812T2 (de) 2007-04-12
DE69932812D1 (de) 2006-09-28
AU756495B2 (en) 2003-01-16
NZ506553A (en) 2002-11-26
EP0947525A1 (en) 1999-10-06
US20030129746A1 (en) 2003-07-10
ATE336512T1 (de) 2006-09-15
CA2321179A1 (en) 1999-10-07
US6841353B2 (en) 2005-01-11
TR200002695T2 (tr) 2000-12-21
JP3657515B2 (ja) 2005-06-08
JP2002510038A (ja) 2002-04-02
US6521403B1 (en) 2003-02-18
HUP0103650A2 (hu) 2002-01-28
AU3602299A (en) 1999-10-18
CN1294598A (zh) 2001-05-09
KR20010042225A (ko) 2001-05-25
ES2272065T3 (es) 2007-04-16
WO1999050301A3 (en) 1999-11-25
IL138586A0 (en) 2001-10-31
PL343638A1 (en) 2001-08-27
WO1999050301A2 (en) 1999-10-07
EP1064309B1 (en) 2006-08-16
HUP0103650A3 (en) 2005-10-28
PT1064309E (pt) 2006-12-29

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