KR910019641A - 사람 유두종 바이러스(hpv) 18의 단백질상의 혈청 반응성 에피토프 - Google Patents

사람 유두종 바이러스(hpv) 18의 단백질상의 혈청 반응성 에피토프 Download PDF

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KR910019641A
KR910019641A KR1019910007527A KR910007527A KR910019641A KR 910019641 A KR910019641 A KR 910019641A KR 1019910007527 A KR1019910007527 A KR 1019910007527A KR 910007527 A KR910007527 A KR 910007527A KR 910019641 A KR910019641 A KR 910019641A
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epitope
hpv18
protein
serum reactive
proteins
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KR1019910007527A
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KR100203547B1 (ko
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블로일 콘라드
기스만 루츠
뮐러 마르틴
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스타인, 부크
베링베르케 아크티엔게젤샤프트
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/275—Poxviridae, e.g. avipoxvirus
    • A61K39/285—Vaccinia virus or variola virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

내용 없음

Description

사람 유두종 바이러스(HPV)18의 단백질상의 혈청 반응성 에피토프
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기의 아미노산 서열을 갖는 HPV18의 E1 단백질상의 혈청 반응성 에피토프.
    TENSPLGERLECDTELSPRLQEISKNS
  2. 하기의 아미노산 서열(I)내지(III)중 어느 하나를 갖는 HPV18의 E6단백질상의 혈청반응성 에피토프.
    I. DPTRRTYKLPDLCTEKNTSKQDIEITCVYCKT
    II. MAPFEDPTRRPYKL
    III.AACHKCKDFYSRIREKRHYSDSVYGDTKEKLT
  3. 하기의 아미노산 서열(I) 및 (II)중 어느 하나를 갖는, HPV18의 E7단백질상의 혈청반응성 에피토프.
    I.VLHLDPQNEIPVDKKCHEQKSDSEEENDEIDGCNHQHLPARRAEPQRH
    II.IDGUNHQHKPARR
  4. 제1항 내지 제3항중 어느 한 항에 따른 혈청반응성 에피토프 하나 이상을 함유하는 펩타이드.
  5. 제4항에 따른 펩타이드 하나이상을 함유하는 백신.
  6. 제4항에 따른 펩타이드 하나 이상을 함유하는, HPV18의 단백질 E1,E6또는 E7에 대한 특이항체를 동정하기 위한 진단 조성물.
  7. 제1항 내지 3항중 어느 한 항에 따른 에피토프 및/또는 제4항에 따른 펩타이드에 선택성이 있는 플리클로날 또는 모노클로날 항체를 함유하는 환자혈청내의 바이러스 단백질을 동정하기 위한 진단 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910007527A 1990-05-10 1991-05-10 사람 유두종 바이러스18의 단백질상의 혈청반응성 에피토프 KR100203547B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4015044,5 1990-05-10
DE4015044A DE4015044A1 (de) 1990-05-10 1990-05-10 Seroreaktive epitope auf proteinen des menschlichen papillomavirus (hpv) 18

Publications (2)

Publication Number Publication Date
KR910019641A true KR910019641A (ko) 1991-12-19
KR100203547B1 KR100203547B1 (ko) 1999-06-15

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KR1019910007527A KR100203547B1 (ko) 1990-05-10 1991-05-10 사람 유두종 바이러스18의 단백질상의 혈청반응성 에피토프

Country Status (9)

Country Link
US (1) US6322794B1 (ko)
EP (1) EP0456197A1 (ko)
JP (3) JP3401022B2 (ko)
KR (1) KR100203547B1 (ko)
AU (1) AU650648B2 (ko)
CA (1) CA2042236C (ko)
DE (1) DE4015044A1 (ko)
IE (1) IE911584A1 (ko)
PT (1) PT97621B (ko)

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GB9207701D0 (en) * 1992-04-08 1992-05-27 Cancer Res Campaign Tech Papillomavirus e7 protein
IL105554A (en) * 1992-05-05 1999-08-17 Univ Leiden Peptides of human papillomavirus for use in preparations elicit a human T cell response
AUPN015794A0 (en) * 1994-12-20 1995-01-19 Csl Limited Variants of human papilloma virus antigens
GB9503570D0 (en) * 1995-02-23 1995-04-12 Kodak Ltd Process and apparatus for the development of photographic materials
CA2211995A1 (en) * 1995-02-24 1996-08-29 Cantab Pharmaceuticals Research Limited Polypeptides useful as immunotherapeutic agents and methods of polypeptide preparation
IL117459A (en) * 1995-03-22 2005-11-20 Merck & Co Inc Dna encoding human papillomavirus type 18
AUPN443995A0 (en) * 1995-07-27 1995-08-17 Csl Limited Papillomavirus polyprotein
US6908615B1 (en) 1996-03-18 2005-06-21 Merck & Co., Inc. DNA encoding human papilloma virus type 18
JP3618497B2 (ja) * 1996-12-27 2005-02-09 富士通株式会社 タンパク質の抗原決定基予測方法及びシステム
GB9717953D0 (en) 1997-08-22 1997-10-29 Smithkline Beecham Biolog Vaccine
US20050100928A1 (en) * 1999-09-16 2005-05-12 Zycos Inc., A Delaware Corporation Nucleic acids encoding polyepitope polypeptides
ES2330078T3 (es) * 1999-09-16 2009-12-04 Eisai Corporation Of North America Acidos nucleicos que codifican polipeptidos poliepitope.
US7026443B1 (en) * 1999-12-10 2006-04-11 Epimmune Inc. Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions
US7312041B2 (en) * 2001-02-16 2007-12-25 Arbor Vita Corporation Methods of diagnosing cervical cancer
US20040229298A1 (en) * 2000-11-11 2004-11-18 Lu Peter S. Methods and compositions for treating cervical cancer
CN1695058B (zh) 2002-09-09 2011-04-13 生命树股份有限公司 诊断宫颈癌的方法
WO2005063286A1 (en) 2003-12-23 2005-07-14 Arbor Vita Corporation Antibodies for oncogenic strains of hpv and methods of their use
DK1576967T3 (da) 2004-03-18 2008-01-21 Pasteur Institut Rekombinant protein, der bærer epitoper fra det humane papillomvirus indsat i et adenylatcyclaseprotein eller et fragment deraf samt dets terapeutiske anvendelse
WO2016006873A1 (ko) * 2014-07-09 2016-01-14 연세대학교 산학협력단 인유두종바이러스 펩타이드의 자궁경부암 진단 및 치료 용도
CN105753980B (zh) * 2016-03-29 2019-04-02 上海市普陀区中心医院 一种hpv18 e6单克隆抗体及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
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US4777239A (en) * 1986-07-10 1988-10-11 The Board Of Trustees Of The Leland Stanford Junior University Diagnostic peptides of human papilloma virus
DE3625257A1 (de) * 1986-07-23 1988-02-04 Behringwerke Ag Expressionsprodukte der menschlichen papillomviren typ 16 und 18, fuer diese proteine spezifische antikoerper und diese antikoerper bzw. entsprechende dna enthaltende diagnostika

Also Published As

Publication number Publication date
DE4015044A1 (de) 1991-11-14
PT97621B (pt) 1998-08-31
JP2001026600A (ja) 2001-01-30
KR100203547B1 (ko) 1999-06-15
US6322794B1 (en) 2001-11-27
AU7621291A (en) 1991-11-14
JP2001017190A (ja) 2001-01-23
CA2042236A1 (en) 1991-11-11
JP3401022B2 (ja) 2003-04-28
PT97621A (pt) 1992-03-31
JPH04227000A (ja) 1992-08-17
IE911584A1 (en) 1991-11-20
EP0456197A1 (de) 1991-11-13
CA2042236C (en) 2002-07-09
JP3676195B2 (ja) 2005-07-27
JP3717755B2 (ja) 2005-11-16
AU650648B2 (en) 1994-06-30

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