KR930008155A - 씨형 간염 바이러스(hcv)에 대한 모노클로날 항체 - Google Patents

씨형 간염 바이러스(hcv)에 대한 모노클로날 항체 Download PDF

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KR930008155A
KR930008155A KR1019920019092A KR920019092A KR930008155A KR 930008155 A KR930008155 A KR 930008155A KR 1019920019092 A KR1019920019092 A KR 1019920019092A KR 920019092 A KR920019092 A KR 920019092A KR 930008155 A KR930008155 A KR 930008155A
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hcv
hepatitis
monoclonal antibodies
virus
monoclonal antibody
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KR1019920019092A
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KR100238559B1 (ko
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빈난트 요한네스 안토니우스 하벳츠
미리암 프란시스카 헨리카 마리아 클라인-로트
테오도투스 아드리아누스 마리아 우스터라켄
싱 히엠 얍
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에프.지.엠.헤르만스, 에이.지.제이.베르미렌
악조 엔.브이.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C07K16/109—Hepatitis C virus; Hepatitis G virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2474/00—Immunochemical assays or immunoassays characterised by detection mode or means of detection
    • G01N2474/20—Immunohistochemistry assay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

본 발명은 C형 간염 바이러스(HCV)코어 단백질상의 에피토프에 대해 결합특이성을 가진 모노클로날 항체를 생성하는 하브리도마 세포주 및 하이브리도마 세포주에 의해 생성된 모노클로날 항체에 관한 것이다.

Description

씨형 간염 바이러스(HCV)에 대한 모노클로날 항체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. C형 간염 바이로스(HCV)코어 단백질상의 에피토프에 대해 결합 특이성을 가진 모노클로날 항체를 생성하는 하이브리도마 세포주.
  2. C형 간염 바이러스 코어 단백질상의 에피토프에 대해 결합 특이성을 가진, 제1항의 하이브리도마 세포주에 의해 생성된 모노클로날 항체.
  3. HCV 코어 에피토프에 대해 유향성인 모노클로날 항체.
  4. 간 생검내에서 측정 또는 검색 가능한 HCV에피토프에 대해 유향정인 모노클로날 항체.
  5. C형 간염 바이러스 코어 단백질상의 에피토프에 대한 특이성을 가진 모노클로날 항체로서, 골수종 세포를 HCV코어 펩티드로 미리 접종한 마우로부터 얻은 임파구과 융합시켜 생성된 하이브리도마 세포주로 부터 생성된 것을 특징으로 하는 모노클로날 항체.
  6. 제5항에 있어서, HCV코어 펩티드가 펩티드 A1327 또는 그의 단편임을 특징으로 하는 모노클로날 항체.
  7. 샘플을 제3항에 따른 모노클로날 항체와 접촉시킨후, 형성된 면역 복합체의 존재를 검색하고 이를 통해 샘플내 HCV의 존재를 결정하는 것을 포함하여 샘플내에서 HCV을 검색하는 방법.
  8. 제7항에 따른 면역-측정법을 수행하기 위한 시험용 킷트.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920019092A 1991-10-15 1992-10-15 씨형 간염 바이러스에 대한 모노클로날 항체 KR100238559B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91202659 1991-10-15
EP91202659.8 1991-10-15

Publications (2)

Publication Number Publication Date
KR930008155A true KR930008155A (ko) 1993-05-21
KR100238559B1 KR100238559B1 (ko) 2000-01-15

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KR1019920019092A KR100238559B1 (ko) 1991-10-15 1992-10-15 씨형 간염 바이러스에 대한 모노클로날 항체

Country Status (11)

Country Link
US (1) US5595868A (ko)
EP (1) EP0537856B1 (ko)
JP (1) JP3335387B2 (ko)
KR (1) KR100238559B1 (ko)
AT (1) ATE162553T1 (ko)
AU (1) AU670541B2 (ko)
CA (1) CA2080548C (ko)
DE (1) DE69224134T2 (ko)
ES (1) ES2114547T3 (ko)
FI (1) FI105275B (ko)
ZA (1) ZA927837B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2049679C (en) * 1990-08-24 2005-06-21 Sushil G. Devare Hepatitis c assay utilizing recombinant antigens
KR930702507A (ko) * 1990-11-07 1993-09-09 챨스 엠. 브록 C형 간염 바이러스에 대한 모노클로날 항체 및 이의 사용 방법
US5753430A (en) * 1990-11-07 1998-05-19 Abbott Laboratories Monoclonal antibodies to hepatitis C virus and method for using same
JP3217600B2 (ja) * 1994-07-12 2001-10-09 株式会社先端生命科学研究所 非ａ非ｂ型肝炎ウイルス関連抗原のイムノアッセイ、それに使用するモノクローナル抗体、およびこの抗体を産生するハイブリドーマ
CN1044384C (zh) * 1994-08-25 1999-07-28 中国药品生物制品检定所 抗丙型肝炎病毒抗原单克隆抗体细胞株建立及其单克隆抗体
US5849800A (en) * 1997-03-28 1998-12-15 The Penn State Research Foundation Use of amantadine for treatment of Hepatitis C
CA2316130A1 (en) * 1999-08-19 2001-02-19 Masanori Fukui Method for detection or determination of hcv core antigens and reagent for detection or determination for use therein
US20030232745A1 (en) * 2001-06-26 2003-12-18 Olson William C. Uses of DC-sign and DC-Signr for inhibiting hepatitis C virus infection
US7022323B2 (en) * 2001-06-26 2006-04-04 Progenics Pharmaceuticals, Inc. Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection
US7049060B2 (en) * 2001-11-05 2006-05-23 Ortho-Clinical Diagnostics, Inc. HCV anti-core monoclonal antibodies
US7858752B2 (en) 2006-12-05 2010-12-28 Abbott Laboratories Recombinant antibodies against hepatitis C virus and methods of obtaining and using same
MX2009008706A (es) 2007-02-21 2009-09-14 Univ Massachusetts Anticuerpos humanos contra el virus de la hepatitis c (hcv) y usos de los mismos.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2012739T5 (es) * 1987-11-18 2001-12-01 Chiron Corp Diagnosticos para nanbv.
US5191064A (en) * 1988-09-30 1993-03-02 The Research Foundation For Microbial Diseases (Osaka University) Non-a, non-b hepatitis virus antigen peptide
WO1990011089A1 (en) * 1989-03-17 1990-10-04 Chiron Corporation Nanbv diagnostics and vaccines
EP0445801A3 (en) * 1990-03-08 1992-07-01 Kuraray Co., Ltd. Peptide and its use
JPH0436185A (ja) * 1990-03-28 1992-02-06 Kyowa Hakko Kogyo Co Ltd 融合抗原ポリペプチド
ZA912040B (en) * 1990-03-30 1991-12-24 Akzo Nv Peptides immunochemically reactive with antibodies directed against hepatitis non-a,non-b virus

Also Published As

Publication number Publication date
FI924641A (fi) 1993-04-16
ES2114547T3 (es) 1998-06-01
US5595868A (en) 1997-01-21
ATE162553T1 (de) 1998-02-15
EP0537856A1 (en) 1993-04-21
ZA927837B (en) 1994-03-11
DE69224134D1 (de) 1998-02-26
DE69224134T2 (de) 1998-07-02
CA2080548A1 (en) 1993-04-16
CA2080548C (en) 2003-07-01
FI105275B (fi) 2000-07-14
JP3335387B2 (ja) 2002-10-15
EP0537856B1 (en) 1998-01-21
KR100238559B1 (ko) 2000-01-15
JPH05260960A (ja) 1993-10-12
AU2707992A (en) 1993-04-22
AU670541B2 (en) 1996-07-25
FI924641A0 (fi) 1992-10-14

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