ATE187494T1 - Multivalente einkettige antikörper - Google Patents

Multivalente einkettige antikörper

Info

Publication number
ATE187494T1
ATE187494T1 AT94903587T AT94903587T ATE187494T1 AT E187494 T1 ATE187494 T1 AT E187494T1 AT 94903587 T AT94903587 T AT 94903587T AT 94903587 T AT94903587 T AT 94903587T AT E187494 T1 ATE187494 T1 AT E187494T1
Authority
AT
Austria
Prior art keywords
single chain
chain antibodies
multivalent single
multivalent
peptide linker
Prior art date
Application number
AT94903587T
Other languages
English (en)
Inventor
Peter S Mezes
Brian B Gourlie
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Application granted granted Critical
Publication of ATE187494T1 publication Critical patent/ATE187494T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT94903587T 1992-12-11 1993-12-10 Multivalente einkettige antikörper ATE187494T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99026392A 1992-12-11 1992-12-11

Publications (1)

Publication Number Publication Date
ATE187494T1 true ATE187494T1 (de) 1999-12-15

Family

ID=25535963

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94903587T ATE187494T1 (de) 1992-12-11 1993-12-10 Multivalente einkettige antikörper

Country Status (9)

Country Link
US (2) US5877291A (de)
EP (1) EP0628078B1 (de)
JP (1) JP3312357B2 (de)
AT (1) ATE187494T1 (de)
CA (1) CA2117477C (de)
DE (1) DE69327229T2 (de)
HK (1) HK1019014A1 (de)
SG (1) SG55079A1 (de)
WO (1) WO1994013806A1 (de)

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JP3312357B2 (ja) 2002-08-05
CA2117477C (en) 2001-06-12
CA2117477A1 (en) 1994-06-23
EP0628078A1 (de) 1994-12-14
EP0628078B1 (de) 1999-12-08
JPH07503622A (ja) 1995-04-20
SG55079A1 (en) 1998-12-21
US5877291A (en) 1999-03-02
HK1019014A1 (en) 2000-01-14
US5892020A (en) 1999-04-06
WO1994013806A1 (en) 1994-06-23
AU680461B2 (en) 1997-07-31
AU5747794A (en) 1994-07-04
DE69327229D1 (de) 2000-01-13
DE69327229T2 (de) 2000-03-30

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