AR061986A1 - Agentes inductores de muerte celular - Google Patents

Agentes inductores de muerte celular

Info

Publication number
AR061986A1
AR061986A1 ARP070103112A ARP070103112A AR061986A1 AR 061986 A1 AR061986 A1 AR 061986A1 AR P070103112 A ARP070103112 A AR P070103112A AR P070103112 A ARP070103112 A AR P070103112A AR 061986 A1 AR061986 A1 AR 061986A1
Authority
AR
Argentina
Prior art keywords
antibody
antibodies
diabody
clones
hla class
Prior art date
Application number
ARP070103112A
Other languages
English (en)
Inventor
Kimura Naoki
Kawai Shigeto
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of AR061986A1 publication Critical patent/AR061986A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se provee un anticuerpo con elevada actividad inductora de apoptosis. Se inmunizaron ratones con células que expresan HLA clase Ia humano y microglobulina b2 humana (b2M) para obtener anticuerpos monoclonales. El análisis de los anticuerpos obtenidos se realizó para obtener diez clones de anticuerpos con actividad inductora de apoptosis. Los análisis de estos clones revelaron que tres de los clones (anticuerpos C3B3, C11B9, y C17D11) con dominio b2 de del antígeno HLA clase I como epítopo, demostraron una actividad citotóxica más fuerte cuando formaban enlaces cruzados con un anticuerpo IgG antimurino. Además, cuando se genera un diacuerpo C3B3, este diacuerpo reveló un efecto antitumoral más fuerte, comparado con diacuerpos convencionales del anticuerpo 2D7, que es un anticuerpo HLA clase IA. Reivindicación 3: Un anticuerpo caracterizado porque comprende regiones variables de cadena pesada que comprende CDR1, 2 y 3 que consiste en las secuencias de aminoácidos de SEQ ID Nº 7, 8 y 9, y regiones variables de cadena liviana que comprende CDR1, 2 y 3 que consiste en las secuencias de aminoácidos SEQ ID Nº 10, 11 y 12. Reivindicación 22: Un agente supresor de crecimiento celular caracterizado porque comprende el anticuerpo de acuerdo con cualquiera de las reivindicaciones 1 a 14 como ingrediente activo.
ARP070103112A 2006-07-13 2007-07-13 Agentes inductores de muerte celular AR061986A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006193053 2006-07-13

Publications (1)

Publication Number Publication Date
AR061986A1 true AR061986A1 (es) 2008-08-10

Family

ID=38923311

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070103112A AR061986A1 (es) 2006-07-13 2007-07-13 Agentes inductores de muerte celular

Country Status (15)

Country Link
US (1) US20100150927A1 (es)
EP (1) EP2048230A4 (es)
JP (1) JPWO2008007755A1 (es)
KR (1) KR20090038896A (es)
CN (1) CN101517075A (es)
AR (1) AR061986A1 (es)
AU (1) AU2007273507A1 (es)
BR (1) BRPI0714209A2 (es)
CA (1) CA2657385A1 (es)
CL (1) CL2007002057A1 (es)
IL (1) IL196134A0 (es)
MX (1) MX2009000487A (es)
PE (1) PE20081004A1 (es)
TW (1) TW200808351A (es)
WO (1) WO2008007755A1 (es)

Families Citing this family (13)

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CL2008000719A1 (es) * 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
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EP2048230A4 (en) 2010-01-20
KR20090038896A (ko) 2009-04-21
JPWO2008007755A1 (ja) 2009-12-10
EP2048230A1 (en) 2009-04-15
US20100150927A1 (en) 2010-06-17
CL2007002057A1 (es) 2008-01-11
CN101517075A (zh) 2009-08-26
PE20081004A1 (es) 2008-09-18
MX2009000487A (es) 2009-01-27
TW200808351A (en) 2008-02-16
CA2657385A1 (en) 2008-01-17
BRPI0714209A2 (pt) 2014-06-24
AU2007273507A1 (en) 2008-01-17
WO2008007755A1 (fr) 2008-01-17

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