ATE243754T1 - Multifunktionelle proteine mit vorbestimmter zielsetzung - Google Patents

Multifunktionelle proteine mit vorbestimmter zielsetzung

Info

Publication number
ATE243754T1
ATE243754T1 AT94201816T AT94201816T ATE243754T1 AT E243754 T1 ATE243754 T1 AT E243754T1 AT 94201816 T AT94201816 T AT 94201816T AT 94201816 T AT94201816 T AT 94201816T AT E243754 T1 ATE243754 T1 AT E243754T1
Authority
AT
Austria
Prior art keywords
proteins
sequences
producing
binding site
binding
Prior art date
Application number
AT94201816T
Other languages
English (en)
Inventor
James S Huston
Hermann Oppermann
Original Assignee
Micromet Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21979976&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE243754(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Micromet Ag filed Critical Micromet Ag
Application granted granted Critical
Publication of ATE243754T1 publication Critical patent/ATE243754T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • External Artificial Organs (AREA)
  • Prostheses (AREA)
AT94201816T 1987-05-21 1988-05-19 Multifunktionelle proteine mit vorbestimmter zielsetzung ATE243754T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5280087A 1987-05-21 1987-05-21

Publications (1)

Publication Number Publication Date
ATE243754T1 true ATE243754T1 (de) 2003-07-15

Family

ID=21979976

Family Applications (2)

Application Number Title Priority Date Filing Date
AT88905298T ATE120761T1 (de) 1987-05-21 1988-05-19 Multifunktionelle proteine mit vorbestimmter zielsetzung.
AT94201816T ATE243754T1 (de) 1987-05-21 1988-05-19 Multifunktionelle proteine mit vorbestimmter zielsetzung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT88905298T ATE120761T1 (de) 1987-05-21 1988-05-19 Multifunktionelle proteine mit vorbestimmter zielsetzung.

Country Status (8)

Country Link
US (2) US5476786A (de)
EP (2) EP0623679B1 (de)
JP (1) JPH02500329A (de)
AT (2) ATE120761T1 (de)
AU (2) AU612370B2 (de)
CA (2) CA1341614C (de)
DE (2) DE3856559T2 (de)
WO (1) WO1988009344A1 (de)

Families Citing this family (676)

* Cited by examiner, † Cited by third party
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ATE120761T1 (de) 1995-04-15
DE3856559D1 (de) 2003-07-31
US6207804B1 (en) 2001-03-27
DE3853515D1 (de) 1995-05-11
EP0318554A1 (de) 1989-06-07
EP0318554B1 (de) 1995-04-05
EP0623679B1 (de) 2003-06-25
CA1341415C (en) 2003-01-07
EP0318554A4 (de) 1990-01-24
AU1804988A (en) 1988-12-21
EP0623679A1 (de) 1994-11-09
AU8579991A (en) 1992-02-13
WO1988009344A1 (en) 1988-12-01
DE3856559T2 (de) 2004-04-29
EP0318554B2 (de) 2005-01-12
CA1341614C (en) 2011-05-24
DE3853515T3 (de) 2005-08-25
JPH02500329A (ja) 1990-02-08
US5476786A (en) 1995-12-19
DE3853515T2 (de) 1995-08-17
AU648591B2 (en) 1994-04-28
AU612370B2 (en) 1991-07-11

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