AR071891A1 - Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano) - Google Patents
Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano)Info
- Publication number
- AR071891A1 AR071891A1 ARP090101855A ARP090101855A AR071891A1 AR 071891 A1 AR071891 A1 AR 071891A1 AR P090101855 A ARP090101855 A AR P090101855A AR P090101855 A ARP090101855 A AR P090101855A AR 071891 A1 AR071891 A1 AR 071891A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- sequence
- antibody
- thirosine
- kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Adem s proporciona metodos para tratar leucemia al administrar una cantidad efectiva de un anticuerpo ya sea solo o en combinacion con un agente anti-c ncer o tratamiento que incluye metotrexato. Reivindicacion 1: Un anticuerpo que enlaza espec¡ficamente el FLT3 humano (SEQ ID Ns 43), caracterizado porque comprende un CDRH1 que tiene la secuencia SYYMH (SEQ ID Ns 2), un CDRH2 que tiene la secuencia IINPSGGSTSYAQKFQG (SEQ ID Ns 3), un CDRH3 que tiene la secuencia GVGAHDAFDI (SEQ ID Ns 4) o VVAAAVADY (SEQ ID Ns 5), un CDRL1 que tiene la secuencia RSSQSLLHSNGNNYLD (SEQ ID Ns 6) o RSSQSLLHSNGYNYLD (SEQ ID Ns 7), un CDRL2 que tiene la secuencia LGSNRAS (SEQ ID Ns 8), y un CDRL3 que tiene la secuencia MQGTHPAIS (SEQ ID Ns 9) o MQSLQTPFT (SEQ ID Ns 11). Reivindicacion 8: Un cido polinucleico aislado, caracterizado porque comprende una secuencia de nucleotidos que codifica el anticuerpo o fragmento de conformidad con cualesquiera de las reivindicaciones 1-7. Reivindicacion 12: Una composicion farmaceutica, caracterizada porque comprende un anticuerpo o fragmento de conformidad con las reivindicaciones 1-7 o 11 junto con un portador, diluyente o excipiente farmaceuticamente aceptable.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13039408P | 2008-05-30 | 2008-05-30 | |
US13039508P | 2008-05-30 | 2008-05-30 | |
US13053908P | 2008-05-30 | 2008-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR071891A1 true AR071891A1 (es) | 2010-07-21 |
Family
ID=41092183
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090101855A AR071891A1 (es) | 2008-05-30 | 2009-05-22 | Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano) |
Country Status (18)
Country | Link |
---|---|
US (3) | US20090297529A1 (es) |
EP (1) | EP2300500A1 (es) |
JP (1) | JP2011521647A (es) |
KR (1) | KR20110004455A (es) |
CN (1) | CN102046659A (es) |
AR (1) | AR071891A1 (es) |
AU (1) | AU2009260517B2 (es) |
BR (1) | BRPI0912173A2 (es) |
CA (1) | CA2726522A1 (es) |
CL (1) | CL2009001277A1 (es) |
EA (1) | EA201071421A1 (es) |
IL (1) | IL209142A0 (es) |
MX (1) | MX2010013144A (es) |
NZ (1) | NZ588791A (es) |
PE (1) | PE20091963A1 (es) |
TW (1) | TWI374032B (es) |
WO (1) | WO2009155015A1 (es) |
ZA (1) | ZA201008024B (es) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR071891A1 (es) * | 2008-05-30 | 2010-07-21 | Imclone Llc | Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano) |
US9109227B2 (en) | 2010-01-05 | 2015-08-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | FLT3 receptor antagonists for the treatment or the prevention of pain disorders |
US20130156764A1 (en) * | 2010-03-12 | 2013-06-20 | The Johns Hopkins University | Neutralization of flt3 ligand as a leukemia therapy |
JP6251678B2 (ja) * | 2011-09-22 | 2017-12-20 | アムジエン・インコーポレーテツド | Cd27l抗原結合タンパク質 |
JP5798199B2 (ja) * | 2012-03-08 | 2015-10-21 | 国立研究開発法人科学技術振興機構 | 抗がん剤 |
ES2939760T3 (es) | 2014-03-15 | 2023-04-26 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico para antígenos |
JP2017528433A (ja) | 2014-07-21 | 2017-09-28 | ノバルティス アーゲー | 低い免疫増強用量のmTOR阻害剤とCARの組み合わせ |
WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
WO2016145099A1 (en) | 2015-03-09 | 2016-09-15 | Agensys, Inc. | Antibody drug conjugates (adc) that bind to flt3 proteins |
US20180298068A1 (en) | 2015-04-23 | 2018-10-18 | Novartis Ag | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
US11667691B2 (en) | 2015-08-07 | 2023-06-06 | Novartis Ag | Treatment of cancer using chimeric CD3 receptor proteins |
EP3569244A1 (en) * | 2015-09-23 | 2019-11-20 | CytoImmune Therapeutics, LLC | Flt3 directed car cells for immunotherapy |
JP7118887B2 (ja) | 2015-11-23 | 2022-08-16 | ノバルティス アーゲー | 最適化されたレンチウイルス移入ベクターおよびその使用 |
RU2018127657A (ru) | 2015-12-30 | 2020-01-31 | Новартис Аг | Виды терапии на основе иммуноэффекторных клеток с улучшенной эффективностью |
EP3432924A1 (en) | 2016-03-23 | 2019-01-30 | Novartis AG | Cell secreted minibodies and uses thereof |
WO2017205747A1 (en) * | 2016-05-27 | 2017-11-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Flt3-specific chimeric antigen receptors and methods using same |
SG11201811290VA (en) | 2016-06-17 | 2019-01-30 | Magenta Therapeutics Inc | Compositions and methods for the depletion of cd117+cells |
WO2018111340A1 (en) | 2016-12-16 | 2018-06-21 | Novartis Ag | Methods for determining potency and proliferative function of chimeric antigen receptor (car)-t cells |
US11236171B2 (en) | 2016-12-21 | 2022-02-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies specific for FLT3 and uses thereof |
WO2018134787A2 (en) | 2017-01-20 | 2018-07-26 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cd137+ cells |
ES2912408T3 (es) | 2017-01-26 | 2022-05-25 | Novartis Ag | Composiciones de CD28 y métodos para terapia con receptores quiméricos para antígenos |
US20190375815A1 (en) | 2017-01-31 | 2019-12-12 | Novartis Ag | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
EP3589647A1 (en) | 2017-02-28 | 2020-01-08 | Novartis AG | Shp inhibitor compositions and uses for chimeric antigen receptor therapy |
JP2020519665A (ja) | 2017-05-17 | 2020-07-02 | アンセルム(アンスティテュト ナショナル ド ラ サンテ エ ド ラ ルシェルシュ メディカル) | オピオイドによる痛みの処置を改善する為のflt3阻害剤 |
MX2019014465A (es) * | 2017-06-02 | 2020-01-23 | Pfizer | Anticuerpos especificos para flt3 y sus usos. |
JP7317718B2 (ja) * | 2017-06-02 | 2023-07-31 | ファイザー・インク | Flt3を標的にするキメラ抗原受容体 |
WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
EP3661554A4 (en) * | 2017-07-31 | 2021-04-21 | Dragonfly Therapeutics, Inc. | PROTEINS BINDING TO NKG2D, CD16 AND FLT3 |
RU2020116579A (ru) | 2017-10-25 | 2021-11-25 | Новартис Аг | Способы получения клеток, экспрессирующих химерный антигенный рецептор |
US20210040205A1 (en) | 2017-10-25 | 2021-02-11 | Novartis Ag | Antibodies targeting cd32b and methods of use thereof |
WO2019089798A1 (en) | 2017-10-31 | 2019-05-09 | Novartis Ag | Anti-car compositions and methods |
WO2019210153A1 (en) | 2018-04-27 | 2019-10-31 | Novartis Ag | Car t cell therapies with enhanced efficacy |
EP3788369A1 (en) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
EP3801769A1 (en) | 2018-05-25 | 2021-04-14 | Novartis AG | Combination therapy with chimeric antigen receptor (car) therapies |
EP3802825A1 (en) | 2018-06-08 | 2021-04-14 | Intellia Therapeutics, Inc. | Compositions and methods for immunooncology |
AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
WO2020128638A1 (en) * | 2018-12-18 | 2020-06-25 | Northern Biologics Inc. | Flt3 agonist antibodies and uses thereof |
BR112021011874A2 (pt) | 2018-12-20 | 2021-09-08 | Novartis Ag | Regime de dosagem e combinação farmacêutica compreendendo derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona |
MX2021009763A (es) | 2019-02-15 | 2021-09-08 | Novartis Ag | Derivados de 3-(1-oxo-5-(piperidin-4-il)isoindolin-2-il)piperidina -2,6-diona y usos de los mismos. |
KR20210129672A (ko) | 2019-02-15 | 2021-10-28 | 노파르티스 아게 | 치환된 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체 및 이의 용도 |
JP2022526194A (ja) * | 2019-04-10 | 2022-05-23 | エレベートバイオ テクノロジーズ,インコーポレイテッド | Flt3特異的キメラ抗原受容体およびその使用方法 |
TW202110873A (zh) * | 2019-04-30 | 2021-03-16 | 美商聖堤生物科技股份有限公司 | 嵌合受體及其使用方法 |
AU2020283742A1 (en) * | 2019-05-24 | 2021-09-16 | Elixiron Immunotherapeutics (hong Kong) Limited | Anti-CSF1R antibodies, IL10 fusion proteins, and uses thereof |
AU2020366000A1 (en) * | 2019-10-15 | 2022-05-12 | Dragonfly Therapeutics, Inc. | Antibodies targeting FLT3 and use thereof |
CA3165399A1 (en) | 2019-12-20 | 2021-06-24 | Novartis Ag | Uses of anti-tgf-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases |
TW202200620A (zh) | 2020-04-14 | 2022-01-01 | 丹麥商賽門弗鎮公司 | 抗flt3抗體及組合物 |
KR20230004680A (ko) | 2020-04-17 | 2023-01-06 | 시티 오브 호프 | Flt3-양성 악성 종양의 치료를 위한 flt3-표적화된 키메라 항원 수용체 변형 세포 |
EP4142749A1 (en) | 2020-04-30 | 2023-03-08 | The Regents of the University of Colorado, A Body Corporate | Multispecific anti-flt3 chimeric antigen receptors |
IL298473A (en) | 2020-06-11 | 2023-01-01 | Novartis Ag | zbtb32 inhibitors and uses thereof |
BR112022026202A2 (pt) | 2020-06-23 | 2023-01-17 | Novartis Ag | Regime de dosagem compreendendo derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona |
CN111808821B (zh) * | 2020-06-24 | 2022-06-14 | 南方医科大学珠江医院 | Flt3-nkg2d双靶点car-t的构建与制备 |
CN116134027A (zh) | 2020-08-03 | 2023-05-16 | 诺华股份有限公司 | 杂芳基取代的3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途 |
MX2023005609A (es) | 2020-11-13 | 2023-05-29 | Novartis Ag | Terapias de combinacion con celulas que expresan receptores quimericos para el antigeno (car). |
TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途 |
WO2022229853A1 (en) | 2021-04-27 | 2022-11-03 | Novartis Ag | Viral vector production system |
AU2022330106A1 (en) * | 2021-08-16 | 2024-03-21 | Hemogenyx Pharmaceuticals Llc | Anti-flt3 antibodies, cars, car t cells and methods of use |
WO2023105087A1 (en) * | 2021-12-10 | 2023-06-15 | Tubulis Gmbh | Novel flt3 antibodies and antibody-drug-conjugates based thereon, therapeutic methods and uses thereof in combination with tyrosine kinase inhibitors |
WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
ATE74118T1 (de) | 1987-04-03 | 1992-04-15 | Hermann Hofmann | Verfahren zum kompostieren von organischen stoffen und vorrichtung zur durchfuehrung dieses verfahrens. |
EP0623679B1 (en) | 1987-05-21 | 2003-06-25 | Micromet AG | Targeted multifunctional proteins |
JPH02503867A (ja) | 1988-04-15 | 1990-11-15 | プロテイン デザイン ラブズ インコーポレーテッド | Il‐2レセプター特異的キメラ抗体 |
AU4128089A (en) * | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5185438A (en) | 1991-04-02 | 1993-02-09 | The Trustees Of Princeton University | Nucleic acids encoding hencatoporetic stem cell receptor flk-2 |
US5367057A (en) * | 1991-04-02 | 1994-11-22 | The Trustees Of Princeton University | Tyrosine kinase receptor flk-2 and fragments thereof |
ATE463573T1 (de) | 1991-12-02 | 2010-04-15 | Medimmune Ltd | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
AU4025193A (en) | 1992-04-08 | 1993-11-18 | Cetus Oncology Corporation | Humanized C-erbB-2 specific antibodies |
US7534867B1 (en) * | 1993-05-19 | 2009-05-19 | Schering Corporation | Purified mammalian Flt3 ligands; agonists; antagonists |
US5554512A (en) | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
JPH09502352A (ja) | 1993-09-08 | 1997-03-11 | イムクローン システムズ インコーポレイテッド | Flk−2レセプターを認識するモノクローナル抗体および原始造血幹細胞集団の単離 |
US5635388A (en) | 1994-04-04 | 1997-06-03 | Genentech, Inc. | Agonist antibodies against the flk2/flt3 receptor and uses thereof |
DE19608769C1 (de) * | 1996-03-07 | 1997-04-10 | Univ Eberhard Karls | Antikörper BV10A4H2 |
US6084060A (en) | 1996-12-09 | 2000-07-04 | Imclone Systems Incorporated | Composition and method for preserving progenitor cells |
DE19727814C1 (de) * | 1997-06-30 | 1998-10-01 | Univ Eberhard Karls | Anitkörper 4G8B4B12 |
WO1999060023A1 (en) | 1998-05-15 | 1999-11-25 | Imclone Systems Incorporated | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases |
US6999122B1 (en) * | 1999-07-22 | 2006-02-14 | Minolta Co., Ltd. | Solid-state logarithmic image sensing device |
WO2002102973A2 (en) | 2001-06-20 | 2002-12-27 | Prochon Biotech Ltd. | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
WO2005094823A1 (ja) | 2004-03-30 | 2005-10-13 | Kyowa Hakko Kogyo Co., Ltd. | Flt-3阻害剤 |
US8227455B2 (en) | 2005-04-18 | 2012-07-24 | Rigel Pharmaceuticals, Inc. | Methods of treating cell proliferative disorders |
BRPI0812400A2 (pt) | 2007-06-05 | 2014-10-29 | Univ Yale | Unidade, hibridoma, composição farmacêutica, método para identificar uma unidade, anticorpo isolado a uma unidade de ligação de antígeno do mesmo, molécula peptídica, e, uso da unidade. |
AR071891A1 (es) * | 2008-05-30 | 2010-07-21 | Imclone Llc | Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano) |
-
2009
- 2009-05-22 AR ARP090101855A patent/AR071891A1/es not_active Application Discontinuation
- 2009-05-25 PE PE2009000733A patent/PE20091963A1/es not_active Application Discontinuation
- 2009-05-25 CL CL2009001277A patent/CL2009001277A1/es unknown
- 2009-05-28 EP EP09767327A patent/EP2300500A1/en not_active Ceased
- 2009-05-28 BR BRPI0912173A patent/BRPI0912173A2/pt not_active IP Right Cessation
- 2009-05-28 NZ NZ588791A patent/NZ588791A/en not_active IP Right Cessation
- 2009-05-28 US US12/473,295 patent/US20090297529A1/en not_active Abandoned
- 2009-05-28 JP JP2011511791A patent/JP2011521647A/ja not_active Withdrawn
- 2009-05-28 KR KR1020107026790A patent/KR20110004455A/ko not_active Application Discontinuation
- 2009-05-28 US US12/994,956 patent/US20110091470A1/en not_active Abandoned
- 2009-05-28 MX MX2010013144A patent/MX2010013144A/es active IP Right Grant
- 2009-05-28 CA CA2726522A patent/CA2726522A1/en not_active Abandoned
- 2009-05-28 AU AU2009260517A patent/AU2009260517B2/en not_active Expired - Fee Related
- 2009-05-28 EA EA201071421A patent/EA201071421A1/ru unknown
- 2009-05-28 WO PCT/US2009/045365 patent/WO2009155015A1/en active Application Filing
- 2009-05-28 CN CN2009801189357A patent/CN102046659A/zh active Pending
- 2009-06-01 TW TW098118092A patent/TWI374032B/zh not_active IP Right Cessation
-
2010
- 2010-09-27 US US12/890,793 patent/US8071099B2/en not_active Expired - Fee Related
- 2010-11-04 IL IL209142A patent/IL209142A0/en unknown
- 2010-11-09 ZA ZA2010/08024A patent/ZA201008024B/en unknown
Also Published As
Publication number | Publication date |
---|---|
NZ588791A (en) | 2012-05-25 |
CL2009001277A1 (es) | 2010-10-08 |
PE20091963A1 (es) | 2010-01-15 |
EA201071421A1 (ru) | 2011-08-30 |
WO2009155015A1 (en) | 2009-12-23 |
TW201010722A (en) | 2010-03-16 |
BRPI0912173A2 (pt) | 2016-07-26 |
US20090297529A1 (en) | 2009-12-03 |
CA2726522A1 (en) | 2009-12-23 |
JP2011521647A (ja) | 2011-07-28 |
AU2009260517A1 (en) | 2009-12-23 |
IL209142A0 (en) | 2011-01-31 |
CN102046659A (zh) | 2011-05-04 |
KR20110004455A (ko) | 2011-01-13 |
EP2300500A1 (en) | 2011-03-30 |
ZA201008024B (en) | 2012-04-25 |
TWI374032B (en) | 2012-10-11 |
MX2010013144A (es) | 2010-12-21 |
AU2009260517B2 (en) | 2012-12-06 |
US20110008355A1 (en) | 2011-01-13 |
US20110091470A1 (en) | 2011-04-21 |
US8071099B2 (en) | 2011-12-06 |
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