BRPI1016055A2 - composição e métodos de uso para anticorpos terapêuticos específicos para a subunidade beta i do receptor de il-12 - Google Patents
composição e métodos de uso para anticorpos terapêuticos específicos para a subunidade beta i do receptor de il-12Info
- Publication number
- BRPI1016055A2 BRPI1016055A2 BRPI1016055A BRPI1016055A BRPI1016055A2 BR PI1016055 A2 BRPI1016055 A2 BR PI1016055A2 BR PI1016055 A BRPI1016055 A BR PI1016055A BR PI1016055 A BRPI1016055 A BR PI1016055A BR PI1016055 A2 BRPI1016055 A2 BR PI1016055A2
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- methods
- therapeutic antibodies
- receptor beta
- specific therapeutic
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16517709P | 2009-04-27 | 2009-04-27 | |
PCT/EP2010/054093 WO2010112458A1 (en) | 2009-03-31 | 2010-03-29 | Composition and methods of use for therapeutic antibodies specific for the il-12 receptore betal subunit |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI1016055A2 true BRPI1016055A2 (pt) | 2016-05-10 |
Family
ID=42174564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI1016055A BRPI1016055A2 (pt) | 2009-04-27 | 2010-03-29 | composição e métodos de uso para anticorpos terapêuticos específicos para a subunidade beta i do receptor de il-12 |
Country Status (11)
Country | Link |
---|---|
US (2) | US8715657B2 (pt) |
EP (1) | EP2424894A1 (pt) |
JP (1) | JP2012524524A (pt) |
KR (1) | KR20120057563A (pt) |
CN (1) | CN102414223A (pt) |
AU (1) | AU2010230311B9 (pt) |
BR (1) | BRPI1016055A2 (pt) |
CA (1) | CA2759942A1 (pt) |
EA (1) | EA201101572A1 (pt) |
MX (1) | MX2011011338A (pt) |
WO (1) | WO2010112458A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010112458A1 (en) * | 2009-03-31 | 2010-10-07 | Novartis Ag | Composition and methods of use for therapeutic antibodies specific for the il-12 receptore betal subunit |
WO2011103105A1 (en) | 2010-02-18 | 2011-08-25 | Bristol-Myers Squibb Company | Fibronectin based scaffold domain proteins that bind il-23 |
CN103154037A (zh) | 2010-10-05 | 2013-06-12 | 诺瓦提斯公司 | 抗IL12Rβ1抗体及它们在治疗自身免疫病和炎性疾病中的用途 |
CN103275222B (zh) * | 2013-05-15 | 2014-04-16 | 中山康方生物医药有限公司 | 一种阻断白介素12 p40功能的单克隆抗体及其编码基因和应用 |
WO2016102641A1 (en) * | 2014-12-24 | 2016-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of acute exacerbations of chronic obstructive pulmonary disease |
KR101873499B1 (ko) * | 2015-02-10 | 2018-07-03 | 주식회사 원메디칼 | 혈관 질환 진단용 바이오 마커 및 이의 용도 |
CN109810947B (zh) * | 2019-01-18 | 2021-06-11 | 北京贝来生物科技有限公司 | 一种抑制Th17细胞活化的间充质干细胞及其制备方法和应用 |
WO2023077091A1 (en) * | 2021-10-28 | 2023-05-04 | Abbvie Inc. | Anti-amyloid beta antibodies and methods of using the same |
WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
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US6698767B2 (en) | 2002-03-11 | 2004-03-02 | Ford Global Technologies, Llc | Adjustable suspension stabilizer bar |
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DK1553975T3 (da) * | 2002-09-27 | 2012-05-07 | Xencor Inc | Optimerede Fc-varianter og fremgangsmåder til generering heraf. |
EP1558640B1 (en) | 2002-10-29 | 2011-04-13 | Anaphore, Inc. | Trimeric binding proteins for trimeric cytokines |
DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
US7981843B2 (en) | 2004-01-20 | 2011-07-19 | Kalobios Pharmaceuticals, Inc. | Antibody specificity transfer using minimal essential binding determinants |
WO2010112458A1 (en) * | 2009-03-31 | 2010-10-07 | Novartis Ag | Composition and methods of use for therapeutic antibodies specific for the il-12 receptore betal subunit |
-
2010
- 2010-03-29 WO PCT/EP2010/054093 patent/WO2010112458A1/en active Application Filing
- 2010-03-29 CN CN2010800186481A patent/CN102414223A/zh active Pending
- 2010-03-29 AU AU2010230311A patent/AU2010230311B9/en not_active Ceased
- 2010-03-29 EP EP10711067A patent/EP2424894A1/en not_active Withdrawn
- 2010-03-29 EA EA201101572A patent/EA201101572A1/ru unknown
- 2010-03-29 KR KR1020117025295A patent/KR20120057563A/ko unknown
- 2010-03-29 CA CA2759942A patent/CA2759942A1/en not_active Abandoned
- 2010-03-29 BR BRPI1016055A patent/BRPI1016055A2/pt not_active IP Right Cessation
- 2010-03-29 JP JP2012502617A patent/JP2012524524A/ja not_active Ceased
- 2010-03-29 MX MX2011011338A patent/MX2011011338A/es not_active Application Discontinuation
- 2010-03-29 US US13/265,346 patent/US8715657B2/en active Active
-
2014
- 2014-03-20 US US14/220,166 patent/US20140248265A1/en not_active Abandoned
Also Published As
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AU2010230311B2 (en) | 2012-08-16 |
US8715657B2 (en) | 2014-05-06 |
EP2424894A1 (en) | 2012-03-07 |
AU2010230311A1 (en) | 2011-10-13 |
WO2010112458A1 (en) | 2010-10-07 |
JP2012524524A (ja) | 2012-10-18 |
EA201101572A1 (ru) | 2012-05-30 |
CN102414223A (zh) | 2012-04-11 |
AU2010230311B9 (en) | 2012-09-20 |
US20140248265A1 (en) | 2014-09-04 |
KR20120057563A (ko) | 2012-06-05 |
WO2010112458A8 (en) | 2012-03-22 |
MX2011011338A (es) | 2012-04-19 |
CA2759942A1 (en) | 2010-10-07 |
US20120034231A1 (en) | 2012-02-09 |
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