BRPI0809931A2 - Antagonistas do receptor do hormônio liberador de gonadotrofina e métodos relacionados com o mesmo - Google Patents

Antagonistas do receptor do hormônio liberador de gonadotrofina e métodos relacionados com o mesmo

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Publication number
BRPI0809931A2
BRPI0809931A2 BRPI0809931-6A2A BRPI0809931A BRPI0809931A2 BR PI0809931 A2 BRPI0809931 A2 BR PI0809931A2 BR PI0809931 A BRPI0809931 A BR PI0809931A BR PI0809931 A2 BRPI0809931 A2 BR PI0809931A2
Authority
BR
Brazil
Prior art keywords
gonadotrophine
receptor antagonists
hormone receptor
methods related
free hormone
Prior art date
Application number
BRPI0809931-6A2A
Other languages
English (en)
Inventor
Graham Beaton
Mi Chen
Timothy Richard Coon
Todd Ewing
Wanlong Jiang
Richaard Lowe
Willy Moree
Nicole Smith
Warren Wade
Liren Zhao
Yun-Fei Zhu
Martin Rowbottom
Neil Ashweek
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of BRPI0809931A2 publication Critical patent/BRPI0809931A2/pt
Publication of BRPI0809931B1 publication Critical patent/BRPI0809931B1/pt
Publication of BRPI0809931B8 publication Critical patent/BRPI0809931B8/pt

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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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