BRPI0809931B8 - antagonistas do receptor do hormônio liberador de gonadotrofina e métodos relacionados com o mesmo - Google Patents

antagonistas do receptor do hormônio liberador de gonadotrofina e métodos relacionados com o mesmo

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Publication number
BRPI0809931B8
BRPI0809931B8 BRPI0809931A BRPI0809931A BRPI0809931B8 BR PI0809931 B8 BRPI0809931 B8 BR PI0809931B8 BR PI0809931 A BRPI0809931 A BR PI0809931A BR PI0809931 A BRPI0809931 A BR PI0809931A BR PI0809931 B8 BRPI0809931 B8 BR PI0809931B8
Authority
BR
Brazil
Prior art keywords
receptor antagonists
gonadotropin
releasing hormone
hormone receptor
related methods
Prior art date
Application number
BRPI0809931A
Other languages
English (en)
Inventor
Beaton Graham
Zhao Liren
Rowbottom Martin
Chen Mi
Ashweek Neil
Smith Nicole
Lowe Richard
Richard Coon Timothy
Ewing Todd
Jiang Wanlong
Wade Warren
Moree Willy
Zhu Yun-Fei
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of BRPI0809931A2 publication Critical patent/BRPI0809931A2/pt
Publication of BRPI0809931B1 publication Critical patent/BRPI0809931B1/pt
Publication of BRPI0809931B8 publication Critical patent/BRPI0809931B8/pt

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    • C07—ORGANIC CHEMISTRY
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
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Abstract

antagonistas do receptor do hormônio liberador de gonadotrofina e método relacionadas com o mesmo. antagonistas do receptor de gnrh são revelados, os quais têm utilidade no tratamento de uma variedade de condições relacionadas com o hormônio sexual tanto em homens quanto em mulheres. os compostos desta invenção têm estrutura, em que r1a r1b r1d r2 r2 e a são conforme definido aqui, incluindo estereoisômeros, ésteres, solvatos e sais farmaceuticamente acetáveis dos mesmo. são também reveladas composições contendo um composto desta invenção em combinação com um veículo farmaceuticamente aceitável, assim como os métodos relacionados com o seu uso para antagonizar o hormônio liberador da gonadotrofina em um indivíduo necessitado disso.
BRPI0809931A 2007-04-06 2008-04-04 antagonistas do receptor do hormônio liberador de gonadotrofina e métodos relacionados com o mesmo BRPI0809931B8 (pt)

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US20140024665A1 (en) 2014-01-23
NZ580457A (en) 2012-03-30
US8084614B2 (en) 2011-12-27
US20210284653A1 (en) 2021-09-16
BRPI0809931A2 (pt) 2014-10-07
UY31009A1 (es) 2008-11-28
US20100152207A1 (en) 2010-06-17
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TW200846324A (en) 2008-12-01
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US20170320888A1 (en) 2017-11-09
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US20250282792A1 (en) 2025-09-11
US10336769B2 (en) 2019-07-02
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AU2008237239B2 (en) 2013-08-29
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US8481738B2 (en) 2013-07-09
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