EA201390977A1 - Комбинация агониста опиоидных рецепторов и антагониста опиоидных рецепторов для лечения болезни паркинсона - Google Patents

Комбинация агониста опиоидных рецепторов и антагониста опиоидных рецепторов для лечения болезни паркинсона

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Publication number
EA201390977A1
EA201390977A1 EA201390977A EA201390977A EA201390977A1 EA 201390977 A1 EA201390977 A1 EA 201390977A1 EA 201390977 A EA201390977 A EA 201390977A EA 201390977 A EA201390977 A EA 201390977A EA 201390977 A1 EA201390977 A1 EA 201390977A1
Authority
EA
Eurasian Patent Office
Prior art keywords
opioid receptor
parkinson
disease
treatment
combination
Prior art date
Application number
EA201390977A
Other languages
English (en)
Other versions
EA025747B1 (ru
Inventor
Михаэль Хопп
Клаудиа Тренквальдер
Original Assignee
Эро-Селтик С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43903970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201390977(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эро-Селтик С.А. filed Critical Эро-Селтик С.А.
Publication of EA201390977A1 publication Critical patent/EA201390977A1/ru
Publication of EA025747B1 publication Critical patent/EA025747B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Настоящим изобретением обеспечивается фармацевтическая лекарственная форма, включающая агонист опиоидных рецепторов и антагонист опиоидных рецепторов, для применения при лечении болезни Паркинсона. Настоящее изобретение также относится к применению агониста опиоидных рецепторов и антагониста опиоидных рецепторов в такой лекарственной форме.
EA201390977A 2010-12-28 2011-12-27 Комбинация агониста опиоидных рецепторов и антагониста опиоидных рецепторов для лечения болезни паркинсона EA025747B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10197210 2010-12-28
PCT/EP2011/074103 WO2012089738A1 (en) 2010-12-28 2011-12-27 A combination of an opioid agonist and an opioid antagonist in the treatment of parkinson's disease

Publications (2)

Publication Number Publication Date
EA201390977A1 true EA201390977A1 (ru) 2013-12-30
EA025747B1 EA025747B1 (ru) 2017-01-30

Family

ID=43903970

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390977A EA025747B1 (ru) 2010-12-28 2011-12-27 Комбинация агониста опиоидных рецепторов и антагониста опиоидных рецепторов для лечения болезни паркинсона

Country Status (19)

Country Link
US (1) US20140037729A1 (ru)
EP (1) EP2658523A1 (ru)
JP (2) JP5864606B2 (ru)
KR (2) KR101632858B1 (ru)
CN (1) CN103347495B (ru)
AR (1) AR084620A1 (ru)
AU (1) AU2011351447B2 (ru)
BR (1) BR112013016862A2 (ru)
CA (1) CA2822528C (ru)
CL (1) CL2013001943A1 (ru)
EA (1) EA025747B1 (ru)
MX (1) MX354125B (ru)
MY (1) MY162895A (ru)
NZ (1) NZ612837A (ru)
SG (1) SG191208A1 (ru)
TW (2) TWI554271B (ru)
UA (1) UA109301C2 (ru)
WO (1) WO2012089738A1 (ru)
ZA (1) ZA201304303B (ru)

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Publication number Priority date Publication date Assignee Title
NZ603170A (en) 2010-05-10 2015-04-24 Euro Celtique Sa Combination of active loaded granules with additional actives
ES2642788T3 (es) 2010-05-10 2017-11-20 Euro-Celtique S.A. Fabricación de gránulos sin principio activo y de comprimidos que comprenden los mismos
KR101632858B1 (ko) * 2010-12-28 2016-06-22 유로-셀티큐 에스.에이. 파킨슨병의 치료에 있어서 오피오이드 효능제와 오피오이드 길항제의 조합물
US10736889B2 (en) 2011-04-29 2020-08-11 Rutgers, The State University Of New Jersey Method of treating dyskinesia
HUE052542T2 (hu) 2011-04-29 2021-05-28 Univ Rutgers Eljárás diszkinézia kezelésére
US9918980B2 (en) 2011-04-29 2018-03-20 Rutgers, The State University Of New Jersey Method of treating dyskinesia
WO2014004126A1 (en) * 2012-06-26 2014-01-03 Fleming C Andrew Treating postoperative nausea and vomiting
KR20180037074A (ko) 2013-07-23 2018-04-10 유로-셀티큐 에스.에이. 장내 세균총이상을 초래하고/하거나 장내 박테리아 전위에 대한 위험을 증가시키는 질환과 통증으로 인해 고통받고 있는 환자에서 통증을 치료하는데 사용하기 위한 옥시코돈과 날록손의 조합물
KR102194174B1 (ko) 2013-11-13 2020-12-23 유로-셀티큐 에스.에이. 통증 및 오피오이드 장 기능장애 증후군의 치료를 위한 히드로모르폰 및 날록손
CA2847781C (en) * 2014-03-28 2019-03-12 Purdue Pharma Reducing drug liking in a subject
US20150352099A1 (en) * 2014-06-04 2015-12-10 Mentinova Inc. Compositions and Methods of Reducing Sedation
EP3183232B1 (en) 2014-08-22 2023-05-03 The Arizona Board of Regents on behalf of The University of Arizona Substituted 1-arylethyl-4-acylaminopiperidine derivatives as opioid/alpha-adrenoreceptor modulators and method of their preparation
WO2016116615A1 (en) * 2015-01-23 2016-07-28 Euro-Celtique S.A. A combination of hydromorphone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
US20160256451A1 (en) * 2015-03-06 2016-09-08 Develco Pharma Schweiz Ag Dosage of naloxone
AU2016266432B2 (en) * 2015-05-26 2020-10-22 Laboratorio Medinfar-Produtos Farmacêuticos, S.A. Compositions for use in treating Parkinson's disease and related disorders
WO2018055199A1 (en) * 2016-09-26 2018-03-29 Euro-Celtique S.A. Methods of treatment comprising administering a high daily dose of oxycodone and naloxone in a 2:1 weight ratio
US20230343429A1 (en) * 2019-10-31 2023-10-26 The United States Government As Represented By The Department Of Veterans Affairs Methods, systems, and apparatus for tapering or uptitrating drug dosages

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US4769372A (en) * 1986-06-18 1988-09-06 The Rockefeller University Method of treating patients suffering from chronic pain or chronic cough
HU229705B1 (en) * 2000-02-08 2014-05-28 Euro Celtique Sa Tamper-resistant oral opioid agonist formulations
CA2386794A1 (en) * 2000-07-13 2002-01-24 Euro-Celtique, S.A. Salts and bases of 17-(cyclopropylmethyl)-4,5 alpha-epoxy-6-methylenemorphinan-3,14 diol for optimizing dopamine homeostasis during administration of opioid analgesics
DE60230632D1 (de) * 2001-07-18 2009-02-12 Euro Celtique Sa Pharmazeutische kombinationen von oxycodon und naloxon
US20060177381A1 (en) * 2002-02-15 2006-08-10 Howard Brooks-Korn Opiopathies
EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
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WO2009132313A2 (en) * 2008-04-25 2009-10-29 Progenics Pharmaceuticals, Inc. Morphinan derivatives of organic and inorganic acids
BRPI0910780A2 (pt) * 2008-07-07 2016-08-09 Euro Celtique Sa uso de antagonistas de opióides para o tratamento da retenção urinária
DK2405915T3 (en) * 2009-03-10 2019-02-11 Euro Celtique Sa PHARMACEUTICAL COMPOSITIONS WITH IMMEDIATE RELEASE INCLUDING OXYCODON AND NALOXON
GB0909680D0 (en) * 2009-06-05 2009-07-22 Euro Celtique Sa Dosage form
KR101632858B1 (ko) * 2010-12-28 2016-06-22 유로-셀티큐 에스.에이. 파킨슨병의 치료에 있어서 오피오이드 효능제와 오피오이드 길항제의 조합물

Also Published As

Publication number Publication date
CN103347495A (zh) 2013-10-09
CA2822528A1 (en) 2012-07-05
MX354125B (es) 2018-02-14
KR101632858B1 (ko) 2016-06-22
CA2822528C (en) 2017-07-18
AR084620A1 (es) 2013-05-29
ZA201304303B (en) 2014-02-26
WO2012089738A1 (en) 2012-07-05
JP2014501268A (ja) 2014-01-20
UA109301C2 (uk) 2015-08-10
TW201628618A (zh) 2016-08-16
TWI554271B (zh) 2016-10-21
AU2011351447A1 (en) 2013-07-25
JP5864606B2 (ja) 2016-02-17
KR101618929B1 (ko) 2016-05-09
MX2013007622A (es) 2013-12-06
EA025747B1 (ru) 2017-01-30
CL2013001943A1 (es) 2013-11-29
NZ612837A (en) 2014-11-28
SG191208A1 (en) 2013-07-31
TW201302199A (zh) 2013-01-16
BR112013016862A2 (pt) 2016-10-04
KR20150076262A (ko) 2015-07-06
US20140037729A1 (en) 2014-02-06
JP6074003B2 (ja) 2017-02-01
CN103347495B (zh) 2017-06-20
MY162895A (en) 2017-07-31
KR20130106431A (ko) 2013-09-27
AU2011351447B2 (en) 2016-02-25
JP2016040268A (ja) 2016-03-24
EP2658523A1 (en) 2013-11-06

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