WO2012032209A3 - Uso de un agonista de trpm8 para la elaboración de un medicamento para el tratamiento de xeroftalmia, sequedad vaginal y síndrome de la boca seca y uso de un antagonista de trpm8 para la elaboración de un medicamento pra el tratamiento de la epífora. - Google Patents
Uso de un agonista de trpm8 para la elaboración de un medicamento para el tratamiento de xeroftalmia, sequedad vaginal y síndrome de la boca seca y uso de un antagonista de trpm8 para la elaboración de un medicamento pra el tratamiento de la epífora. Download PDFInfo
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- WO2012032209A3 WO2012032209A3 PCT/ES2011/070627 ES2011070627W WO2012032209A3 WO 2012032209 A3 WO2012032209 A3 WO 2012032209A3 ES 2011070627 W ES2011070627 W ES 2011070627W WO 2012032209 A3 WO2012032209 A3 WO 2012032209A3
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- treatment
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Abstract
La invención se relaciona con composiciones terapéuticas para el tratamiento del ojo seco y, más concretamente, con composiciones que comprenden un ligando agonista del receptor TRPM8. Así mismo la invención se relaciona con composiciones terapéuticas para el tratamiento de la epifora y, más concretamente con composiciones que comprenden un antagonista del receptor TRPM8.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP23183121.5A EP4268814A3 (en) | 2010-09-08 | 2011-09-08 | Pharmaceutical composition for the treatment of dry eye |
JP2013527651A JP2013537887A (ja) | 2010-09-08 | 2011-09-08 | ドライアイの治療用医薬組成物 |
EP11823113.3A EP2614860A4 (en) | 2010-09-08 | 2011-09-08 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE |
US13/821,840 US9095609B2 (en) | 2010-09-08 | 2011-09-08 | Ophthalmic composition comprising ws-12 and methods to treat xerophthalmia |
US14/699,873 US9433679B2 (en) | 2010-09-08 | 2015-04-29 | Use of TRMP8 for treating opthalmic diseases or conditions involving tearing |
US15/227,436 US9901549B2 (en) | 2010-09-08 | 2016-08-03 | Method for treating vaginal dryness by administering transient receptor potential cation channel subfamily M member 8 (TRPM8) receptor agonists |
US15/350,938 US10028920B2 (en) | 2010-09-08 | 2016-11-14 | Methods for treating occular irritation involving tearing by administering modulators of TRPM8 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ESP201031341 | 2010-09-08 | ||
ES201031341A ES2377785B2 (es) | 2010-09-08 | 2010-09-08 | Composición farmacéutica para el tratamiento del ojo seco. |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/821,840 A-371-Of-International US9095609B2 (en) | 2010-09-08 | 2011-09-08 | Ophthalmic composition comprising ws-12 and methods to treat xerophthalmia |
US14/699,873 Continuation US9433679B2 (en) | 2010-09-08 | 2015-04-29 | Use of TRMP8 for treating opthalmic diseases or conditions involving tearing |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012032209A2 WO2012032209A2 (es) | 2012-03-15 |
WO2012032209A3 true WO2012032209A3 (es) | 2012-07-12 |
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EP (2) | EP4268814A3 (es) |
JP (4) | JP2013537887A (es) |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2377785B2 (es) * | 2010-09-08 | 2012-09-26 | Universidad Miguel Hernández De Elche | Composición farmacéutica para el tratamiento del ojo seco. |
JP6110124B2 (ja) * | 2012-04-18 | 2017-04-05 | 花王株式会社 | 運動神経活性化用皮膚塗布剤 |
CN103040976B (zh) * | 2012-12-31 | 2014-01-15 | 刘建贞 | 一种促进面神经损伤外科吻合术后康复的药物 |
JP6352413B2 (ja) * | 2013-10-22 | 2018-07-04 | エドワード タク ウェイWEI, Edward Tak | 感覚的不快感の治療向け局所薬としてのジ−イソプロピル−アルカン(dapa)化合物 |
WO2015108136A1 (ja) * | 2014-01-17 | 2015-07-23 | キッセイ薬品工業株式会社 | α-置換グリシンアミド誘導体 |
US20150290029A1 (en) * | 2014-04-11 | 2015-10-15 | Edward Tak Wei | Delivery Systems for Agents to treat Ocular Discomfort |
EP3212162A2 (en) * | 2014-10-31 | 2017-09-06 | Avent, Inc. | Method and articles for inhibiting bladder contractions |
JP7096152B2 (ja) * | 2015-10-06 | 2022-07-05 | オーラ・インコーポレーテッド | 一過性受容体電位カチオンチャネルサブファミリーmメンバー8(trpm8)拮抗薬及び使用方法 |
EP3184524A1 (en) | 2015-12-21 | 2017-06-28 | Dompé farmaceutici S.p.A. | 4-hydroxy-2-phenyl-1,3-thiazol-5-yl methanone derivatives as trpm8 antagonists |
ES2625393A1 (es) * | 2016-01-19 | 2017-07-19 | Universidad Miguel Hernandez De Elche | Compuestos agonistas del receptor trpm8 y sus aplicaciones |
JP2020531473A (ja) * | 2017-08-18 | 2020-11-05 | ザ スケペンス アイ リサーチ インスティテュート,インコーポレイテッド | ドライアイの処置のための組成物およびその使用の方法 |
GB201807305D0 (en) * | 2018-05-03 | 2018-06-20 | Nicoventures Trading Ltd | Vaporisable formulation |
JP6564498B2 (ja) * | 2018-06-06 | 2019-08-21 | エドワード タク ウェイWEI, Edward Tak | 感覚的不快感の治療向け局所薬としてのジ−イソプロピル−アルカン(dapa)化合物 |
WO2021195256A1 (en) * | 2020-03-24 | 2021-09-30 | Aerie Pharmaceuticals, Inc. | Pharmaceutical preparation |
US20220087997A1 (en) * | 2020-09-22 | 2022-03-24 | Fertin Pharma A/S | Oral Antagonist Compositions For Nicotine Burning Relief |
WO2022105986A1 (de) * | 2020-11-17 | 2022-05-27 | Symrise Ag | Neue kühlstoffe und zubereitungen, die diese enthalten |
US20220350163A1 (en) | 2021-04-29 | 2022-11-03 | Coopervision International Limited | Ws12-releasing contact lens |
KR20240019801A (ko) * | 2021-06-08 | 2024-02-14 | 프리시비전 바이오테크놀로지스 리미티드 | 진드기의 억제 또는 사멸 및 안구건조증의 치료에서의 화합물의 용도 |
WO2023114986A1 (en) | 2021-12-17 | 2023-06-22 | Aerie Pharmaceuticals, Inc. | Ophthalmic pharmaceutical compositions and uses thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003099278A1 (en) * | 2002-05-28 | 2003-12-04 | Altana Pharma Ag | Ophthalmological use of roflumilast for the treatment of diseases of the eye |
WO2007099503A2 (en) * | 2006-02-28 | 2007-09-07 | The Gillette Company | Reduction of hair growth |
WO2010017609A2 (en) * | 2008-08-11 | 2010-02-18 | Natural Cosmeticos S.A. | Antiperspirant compositions and methods for reducing perspiration in humans |
WO2010021882A2 (en) * | 2008-08-19 | 2010-02-25 | Janssen Pharmaceutica Nv | Cold menthol receptor antagonists |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57179121A (en) | 1981-04-27 | 1982-11-04 | Showa Kagaku Kogyo Kk | Remedy for oculopathy |
US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
US5176996A (en) | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
US5256775A (en) | 1989-06-05 | 1993-10-26 | Gilead Sciences, Inc. | Exonuclease-resistant oligonucleotides |
US5264564A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
JPH1067684A (ja) * | 1996-06-17 | 1998-03-10 | Mitsubishi Chem Corp | 涙液分泌促進剤 |
NZ334691A (en) | 1996-10-11 | 2000-12-22 | Bristol Myers Squibb Co | Compositions of anti-4-1BB antibody effective for immunomodulation and treatment of T-cell autoimmune disease |
CN1199617A (zh) | 1996-12-18 | 1998-11-25 | 虎发光 | 一种治疗眼病的中成药 |
JPH10236972A (ja) * | 1997-02-28 | 1998-09-08 | Mitsubishi Chem Corp | 涙液分泌促進剤 |
JP4591728B2 (ja) * | 1998-12-28 | 2010-12-01 | 大正製薬株式会社 | 眼精疲労改善用点眼剤 |
JP3142842B1 (ja) * | 1999-10-22 | 2001-03-07 | ライオン株式会社 | 眼科用組成物及びソフトコンタクトレンズへの吸着抑制方法 |
EP1153614A1 (en) * | 1999-12-07 | 2001-11-14 | Rohto Pharmaceutical Co., Ltd. | Ophthalmic compositions |
AU2002364935A1 (en) | 2001-10-09 | 2003-06-23 | Mayo Foundation For Medical Education And Research | Enhancement of immune responses by 4-1bb-binding agents |
AU2003210663A1 (en) * | 2002-01-25 | 2003-09-02 | The Regents Of The University Of California | Methods of modulating cold sensory perception |
US6919348B2 (en) * | 2002-05-02 | 2005-07-19 | Edward T. Wei | Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith |
JP2005536511A (ja) | 2002-07-15 | 2005-12-02 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ | 4−1bb結合物質を用いる治療及び予防 |
JP2006500921A (ja) | 2002-07-30 | 2006-01-12 | ブリストル−マイヤーズ スクイブ カンパニー | ヒト4−1bbに対するヒト化抗体 |
IL152486A0 (en) * | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
DE10259619A1 (de) * | 2002-12-18 | 2004-07-08 | Metagen Pharmaceuticals Gmbh | Verwendung einer TRPM8 aktivierenden Substanz zur Tumorbehandlung |
JP4601265B2 (ja) * | 2003-05-14 | 2010-12-22 | ロート製薬株式会社 | 局所適用製剤 |
JP5105873B2 (ja) * | 2003-07-02 | 2012-12-26 | ジェネンテック, インコーポレイテッド | Trp−p8活性化合物と治療的処置方法 |
CN1565501A (zh) | 2003-07-08 | 2005-01-19 | 毛友昌 | 明目地黄新的制备工艺及其制剂 |
US20050137166A1 (en) * | 2003-12-19 | 2005-06-23 | Alcon, Inc. | Use of cooling agents to relieve mild ocular irritation and enhance comfort |
EP1802600A1 (en) | 2004-10-13 | 2007-07-04 | Bayer HealthCare AG | Substituted 4-benzyloxy-phenylmethylamide derivatives as cold menthol receptor-1 (cmr-1) antagonits for the treatment of urological disorders |
US20060111388A1 (en) * | 2004-11-19 | 2006-05-25 | University Of North Texas Health Science Center At Fort Worth | Phenanthroline and derivatives thereof used to lower intraocular pressure in an affected eye |
JP5078254B2 (ja) * | 2004-12-17 | 2012-11-21 | ロート製薬株式会社 | 眼科用組成物 |
WO2006088447A1 (en) | 2005-02-15 | 2006-08-24 | Gtc Biotherapeutics, Inc. | An anti-cd137 antibody as an agent in the treatement of cancer and glycosylation variants thereof |
GB0504194D0 (en) * | 2005-03-02 | 2005-04-06 | Givaudan Sa | Organic compounds |
WO2007017092A1 (en) | 2005-08-04 | 2007-02-15 | Bayer Healthcare Ag | Substituted 4-benzyloxy-benzoic acid amide derivatives |
CN1775261A (zh) | 2005-11-18 | 2006-05-24 | 北京阜康仁生物制药科技有限公司 | 明目地黄制剂及新的制备方法 |
CN1775263A (zh) | 2005-11-18 | 2006-05-24 | 北京阜康仁生物制药科技有限公司 | 杞菊地黄制剂及新的制备方法 |
RU2305517C1 (ru) | 2006-03-09 | 2007-09-10 | Сергей Васильевич Широков | Способ лечения эпифоры |
KR101381035B1 (ko) * | 2006-03-23 | 2014-04-04 | 센주 세이야꾸 가부시키가이샤 | 잔탄검 및 글루코스를 포함하는 안약 조성물 |
US7887859B2 (en) | 2006-11-02 | 2011-02-15 | Riolan Technologies, Inc. | Methods of treating epiphora |
GB2451503B (en) * | 2007-08-01 | 2011-10-12 | Lrc Products | Stimulating gel comprising a cyclic carboxamide coolant |
CN101612199A (zh) | 2008-06-28 | 2009-12-30 | 孙斌 | 治疗眼睛红肿和遇风流泪的冲洗液 |
ES2377785B2 (es) * | 2010-09-08 | 2012-09-26 | Universidad Miguel Hernández De Elche | Composición farmacéutica para el tratamiento del ojo seco. |
-
2010
- 2010-09-08 ES ES201031341A patent/ES2377785B2/es active Active
-
2011
- 2011-09-08 EP EP23183121.5A patent/EP4268814A3/en active Pending
- 2011-09-08 US US13/821,840 patent/US9095609B2/en active Active
- 2011-09-08 EP EP11823113.3A patent/EP2614860A4/en not_active Ceased
- 2011-09-08 JP JP2013527651A patent/JP2013537887A/ja not_active Withdrawn
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-
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- 2021-04-14 JP JP2021068077A patent/JP2021107422A/ja active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003099278A1 (en) * | 2002-05-28 | 2003-12-04 | Altana Pharma Ag | Ophthalmological use of roflumilast for the treatment of diseases of the eye |
WO2007099503A2 (en) * | 2006-02-28 | 2007-09-07 | The Gillette Company | Reduction of hair growth |
WO2010017609A2 (en) * | 2008-08-11 | 2010-02-18 | Natural Cosmeticos S.A. | Antiperspirant compositions and methods for reducing perspiration in humans |
WO2010021882A2 (en) * | 2008-08-19 | 2010-02-25 | Janssen Pharmaceutica Nv | Cold menthol receptor antagonists |
Non-Patent Citations (2)
Title |
---|
HAGHIGHI, A.B. ET AL.: "Therapeutic potentials of menthol in migraine headache: Possible mechanismsof action", MEDICAL HIPOTHESIS, vol. 69, no. 2, 2007, pages 455 * |
PARRA, A. ET AL.: "Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea", NATURE MEDICINE, vol. 16, no. 12, 14 November 2010 (2010-11-14), pages 1396 - 1399 * |
Also Published As
Publication number | Publication date |
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JP2013537887A (ja) | 2013-10-07 |
JP2021107422A (ja) | 2021-07-29 |
US20170071875A1 (en) | 2017-03-16 |
US9095609B2 (en) | 2015-08-04 |
WO2012032209A2 (es) | 2012-03-15 |
ES2377785A1 (es) | 2012-04-02 |
JP2019131621A (ja) | 2019-08-08 |
US20170049728A1 (en) | 2017-02-23 |
JP2017036298A (ja) | 2017-02-16 |
US9901549B2 (en) | 2018-02-27 |
US20130245231A1 (en) | 2013-09-19 |
ES2377785B2 (es) | 2012-09-26 |
US9433679B2 (en) | 2016-09-06 |
US20150313854A1 (en) | 2015-11-05 |
EP4268814A2 (en) | 2023-11-01 |
EP2614860A2 (en) | 2013-07-17 |
EP4268814A3 (en) | 2024-01-24 |
US10028920B2 (en) | 2018-07-24 |
EP2614860A4 (en) | 2014-01-29 |
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