WO2012032209A3 - Uso de un agonista de trpm8 para la elaboración de un medicamento para el tratamiento de xeroftalmia, sequedad vaginal y síndrome de la boca seca y uso de un antagonista de trpm8 para la elaboración de un medicamento pra el tratamiento de la epífora. - Google Patents
Uso de un agonista de trpm8 para la elaboración de un medicamento para el tratamiento de xeroftalmia, sequedad vaginal y síndrome de la boca seca y uso de un antagonista de trpm8 para la elaboración de un medicamento pra el tratamiento de la epífora. Download PDFInfo
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- WO2012032209A3 WO2012032209A3 PCT/ES2011/070627 ES2011070627W WO2012032209A3 WO 2012032209 A3 WO2012032209 A3 WO 2012032209A3 ES 2011070627 W ES2011070627 W ES 2011070627W WO 2012032209 A3 WO2012032209 A3 WO 2012032209A3
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- WIPO (PCT)
- Prior art keywords
- treatment
- dry eye
- pharmaceutical composition
- compositions
- specifically
- Prior art date
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- 208000003556 Dry Eye Syndromes Diseases 0.000 title abstract 2
- 206010013774 Dry eye Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 102000003610 TRPM8 Human genes 0.000 abstract 2
- 101150111302 Trpm8 gene Proteins 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 241000909851 Epiphora Species 0.000 abstract 1
- 208000016747 lacrimal apparatus disease Diseases 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
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Abstract
La invención se relaciona con composiciones terapéuticas para el tratamiento del ojo seco y, más concretamente, con composiciones que comprenden un ligando agonista del receptor TRPM8. Así mismo la invención se relaciona con composiciones terapéuticas para el tratamiento de la epifora y, más concretamente con composiciones que comprenden un antagonista del receptor TRPM8.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
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JP2013527651A JP2013537887A (ja) | 2010-09-08 | 2011-09-08 | ドライアイの治療用医薬組成物 |
US13/821,840 US9095609B2 (en) | 2010-09-08 | 2011-09-08 | Ophthalmic composition comprising ws-12 and methods to treat xerophthalmia |
EP11823113.3A EP2614860A4 (en) | 2010-09-08 | 2011-09-08 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE |
EP23183121.5A EP4268814A3 (en) | 2010-09-08 | 2011-09-08 | Pharmaceutical composition for the treatment of dry eye |
US14/699,873 US9433679B2 (en) | 2010-09-08 | 2015-04-29 | Use of TRMP8 for treating opthalmic diseases or conditions involving tearing |
US15/227,436 US9901549B2 (en) | 2010-09-08 | 2016-08-03 | Method for treating vaginal dryness by administering transient receptor potential cation channel subfamily M member 8 (TRPM8) receptor agonists |
US15/350,938 US10028920B2 (en) | 2010-09-08 | 2016-11-14 | Methods for treating occular irritation involving tearing by administering modulators of TRPM8 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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ESP201031341 | 2010-09-08 | ||
ES201031341A ES2377785B2 (es) | 2010-09-08 | 2010-09-08 | Composición farmacéutica para el tratamiento del ojo seco. |
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US13/821,840 A-371-Of-International US9095609B2 (en) | 2010-09-08 | 2011-09-08 | Ophthalmic composition comprising ws-12 and methods to treat xerophthalmia |
US14/699,873 Continuation US9433679B2 (en) | 2010-09-08 | 2015-04-29 | Use of TRMP8 for treating opthalmic diseases or conditions involving tearing |
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WO2012032209A2 WO2012032209A2 (es) | 2012-03-15 |
WO2012032209A3 true WO2012032209A3 (es) | 2012-07-12 |
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PCT/ES2011/070627 WO2012032209A2 (es) | 2010-09-08 | 2011-09-08 | Composición farmacéutica para el tratamiento del ojo seco |
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US (4) | US9095609B2 (es) |
EP (2) | EP4268814A3 (es) |
JP (5) | JP2013537887A (es) |
ES (1) | ES2377785B2 (es) |
WO (1) | WO2012032209A2 (es) |
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ES2377785B2 (es) * | 2010-09-08 | 2012-09-26 | Universidad Miguel Hernández De Elche | Composición farmacéutica para el tratamiento del ojo seco. |
JP6110124B2 (ja) * | 2012-04-18 | 2017-04-05 | 花王株式会社 | 運動神経活性化用皮膚塗布剤 |
CN103040976B (zh) * | 2012-12-31 | 2014-01-15 | 刘建贞 | 一种促进面神经损伤外科吻合术后康复的药物 |
JP6352413B2 (ja) * | 2013-10-22 | 2018-07-04 | エドワード タク ウェイWEI, Edward Tak | 感覚的不快感の治療向け局所薬としてのジ−イソプロピル−アルカン(dapa)化合物 |
JP6692162B2 (ja) * | 2014-01-17 | 2020-05-13 | キッセイ薬品工業株式会社 | α−置換グリシンアミド誘導体 |
US20150290029A1 (en) * | 2014-04-11 | 2015-10-15 | Edward Tak Wei | Delivery Systems for Agents to treat Ocular Discomfort |
CA2966345A1 (en) * | 2014-10-31 | 2016-05-06 | Avent, Inc. | Method and articles for inhibiting bladder contractions |
WO2017062570A1 (en) * | 2015-10-06 | 2017-04-13 | Ora, Inc. | Transient receptor potential cation channel subfamily m member 8 (trpm8) antagonists and methods of use |
EP3184524A1 (en) | 2015-12-21 | 2017-06-28 | Dompé farmaceutici S.p.A. | 4-hydroxy-2-phenyl-1,3-thiazol-5-yl methanone derivatives as trpm8 antagonists |
ES2625393A1 (es) * | 2016-01-19 | 2017-07-19 | Universidad Miguel Hernandez De Elche | Compuestos agonistas del receptor trpm8 y sus aplicaciones |
JP2020531473A (ja) * | 2017-08-18 | 2020-11-05 | ザ スケペンス アイ リサーチ インスティテュート,インコーポレイテッド | ドライアイの処置のための組成物およびその使用の方法 |
GB201807305D0 (en) * | 2018-05-03 | 2018-06-20 | Nicoventures Trading Ltd | Vaporisable formulation |
JP6564498B2 (ja) * | 2018-06-06 | 2019-08-21 | エドワード タク ウェイWEI, Edward Tak | 感覚的不快感の治療向け局所薬としてのジ−イソプロピル−アルカン(dapa)化合物 |
CN113677334B (zh) * | 2019-02-01 | 2024-04-09 | 马歇尔大学科研协会 | 瞬时受体电位melastatin 8(trpm8)拮抗剂和相关方法 |
WO2021195256A1 (en) * | 2020-03-24 | 2021-09-30 | Aerie Pharmaceuticals, Inc. | Pharmaceutical preparation |
US20220087997A1 (en) * | 2020-09-22 | 2022-03-24 | Fertin Pharma A/S | Oral Antagonist Compositions For Nicotine Burning Relief |
WO2022105986A1 (de) * | 2020-11-17 | 2022-05-27 | Symrise Ag | Neue kühlstoffe und zubereitungen, die diese enthalten |
US20220350163A1 (en) | 2021-04-29 | 2022-11-03 | Coopervision International Limited | Ws12-releasing contact lens |
CN117440809A (zh) * | 2021-06-08 | 2024-01-23 | 广州珍实视界生物医药科技有限公司 | 化合物在抑制或杀灭螨虫及治疗干眼症中的应用 |
WO2023114986A1 (en) | 2021-12-17 | 2023-06-22 | Aerie Pharmaceuticals, Inc. | Ophthalmic pharmaceutical compositions and uses thereof |
WO2024094974A1 (en) | 2022-10-31 | 2024-05-10 | Coopervision International Limited | Ws12-releasing contact lens |
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-
2010
- 2010-09-08 ES ES201031341A patent/ES2377785B2/es active Active
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2011
- 2011-09-08 JP JP2013527651A patent/JP2013537887A/ja not_active Withdrawn
- 2011-09-08 EP EP23183121.5A patent/EP4268814A3/en active Pending
- 2011-09-08 EP EP11823113.3A patent/EP2614860A4/en not_active Ceased
- 2011-09-08 WO PCT/ES2011/070627 patent/WO2012032209A2/es active Application Filing
- 2011-09-08 US US13/821,840 patent/US9095609B2/en active Active
-
2015
- 2015-04-29 US US14/699,873 patent/US9433679B2/en active Active
-
2016
- 2016-08-03 US US15/227,436 patent/US9901549B2/en active Active
- 2016-09-28 JP JP2016190040A patent/JP2017036298A/ja not_active Withdrawn
- 2016-11-14 US US15/350,938 patent/US10028920B2/en active Active
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2019
- 2019-05-20 JP JP2019094210A patent/JP2019131621A/ja active Pending
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2021
- 2021-04-14 JP JP2021068077A patent/JP2021107422A/ja not_active Ceased
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2024
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Also Published As
Publication number | Publication date |
---|---|
US9095609B2 (en) | 2015-08-04 |
JP2013537887A (ja) | 2013-10-07 |
US10028920B2 (en) | 2018-07-24 |
EP2614860A2 (en) | 2013-07-17 |
US20150313854A1 (en) | 2015-11-05 |
JP2021107422A (ja) | 2021-07-29 |
US20170049728A1 (en) | 2017-02-23 |
EP2614860A4 (en) | 2014-01-29 |
ES2377785B2 (es) | 2012-09-26 |
EP4268814A3 (en) | 2024-01-24 |
JP2017036298A (ja) | 2017-02-16 |
US20130245231A1 (en) | 2013-09-19 |
EP4268814A2 (en) | 2023-11-01 |
ES2377785A1 (es) | 2012-04-02 |
US20170071875A1 (en) | 2017-03-16 |
JP2019131621A (ja) | 2019-08-08 |
WO2012032209A2 (es) | 2012-03-15 |
JP2024069452A (ja) | 2024-05-21 |
US9433679B2 (en) | 2016-09-06 |
US9901549B2 (en) | 2018-02-27 |
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