EA200970928A1 - Антагонисты рецептора гонадотропин-рилизин-фактора и способы их применения - Google Patents

Антагонисты рецептора гонадотропин-рилизин-фактора и способы их применения

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Publication number
EA200970928A1
EA200970928A1 EA200970928A EA200970928A EA200970928A1 EA 200970928 A1 EA200970928 A1 EA 200970928A1 EA 200970928 A EA200970928 A EA 200970928A EA 200970928 A EA200970928 A EA 200970928A EA 200970928 A1 EA200970928 A1 EA 200970928A1
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EA
Eurasian Patent Office
Prior art keywords
gonadotropin
antagonists
methods
rilizin
factor receptor
Prior art date
Application number
EA200970928A
Other languages
English (en)
Other versions
EA017029B1 (ru
Inventor
Грэхэм Битон
Ми Чэнь
Тимоти Ричард Кун
Тодд Эвинг
Ваньлун Цзян
Ричард Лоу
Вилли Мори
Николь Смит
Уоррен Уэйд
Лижэнь Чжао
Юнь-Фэй Чжу
Мартин Роуботтом
Нейл Эшвик
Original Assignee
Ньюрокрайн Байосайенсиз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Ньюрокрайн Байосайенсиз, Инк. filed Critical Ньюрокрайн Байосайенсиз, Инк.
Publication of EA200970928A1 publication Critical patent/EA200970928A1/ru
Publication of EA017029B1 publication Critical patent/EA017029B1/ru

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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Описаны антагонисты рецептора GnRH, которые применяют в лечении ряда расстройств, связанных с половыми гормонами, как у мужчин, так и у женщин. Соединения по настоящему изобретению имеют структуругде R, R, R, R, R, Rи А являются такими, как определено в настоящем документе, включая их стереоизомеры, сложные эфиры, сольваты и фармацевтически приемлемые соли. Также описаны композиции, содержащие соединение по настоящему изобретению в сочетании с фармацевтически приемлемым носителем, а также способы, относящиеся к их применению для антагонистического воздействия на гонадотропин-рилизин-фактор пациента, нуждающегося в этом.
EA200970928A 2007-04-06 2008-04-04 Антагонисты рецептора гонадотропин-рилизинг-фактора и способы их применения EA017029B1 (ru)

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IL201262A (en) 2016-02-29
BRPI0809931B8 (pt) 2021-05-25
ES2534573T3 (es) 2015-04-24
CA2683431A1 (en) 2008-10-16
US8481738B2 (en) 2013-07-09
EP2155194A1 (en) 2010-02-24
US9422310B2 (en) 2016-08-23
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US10941159B2 (en) 2021-03-09
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US20200095259A1 (en) 2020-03-26
TWI423958B (zh) 2014-01-21
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