MX2011013648A - Nuevos compuestos, composiciones farmaceuticas y metodos relacionados con ellos. - Google Patents
Nuevos compuestos, composiciones farmaceuticas y metodos relacionados con ellos.Info
- Publication number
- MX2011013648A MX2011013648A MX2011013648A MX2011013648A MX2011013648A MX 2011013648 A MX2011013648 A MX 2011013648A MX 2011013648 A MX2011013648 A MX 2011013648A MX 2011013648 A MX2011013648 A MX 2011013648A MX 2011013648 A MX2011013648 A MX 2011013648A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- new compounds
- methods relating
- pharmaceutical composition
- patient
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Se describen nuevos compuestos que tienen utilidad en el tratamiento de una diversidad de afecciones relacionadas con el metabolismo en un paciente. Los compuestos de esta invención tienen la estructura (I): (ver fórmula (I)) en la que R1, R2, R3, n, p, c y Ar son como se han definido en la presente memoria, incluyendo estereoisómeros, solvatos y sales farmacéuticamente aceptables de los mismos. También se describen composiciones farmacéuticas que comprenden un compuesto de esta invención, así como métodos relacionados con el uso de los mismos en un paciente que lo necesita.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22013309P | 2009-06-24 | 2009-06-24 | |
PCT/EP2010/058873 WO2010149684A1 (en) | 2009-06-24 | 2010-06-23 | New compounds, pharmaceutical composition and methods relating thereto |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2011013648A true MX2011013648A (es) | 2012-03-06 |
Family
ID=42557541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011013648A MX2011013648A (es) | 2009-06-24 | 2010-06-23 | Nuevos compuestos, composiciones farmaceuticas y metodos relacionados con ellos. |
Country Status (18)
Country | Link |
---|---|
US (1) | US8293729B2 (es) |
EP (1) | EP2445878A1 (es) |
JP (1) | JP5467151B2 (es) |
KR (1) | KR20120046188A (es) |
CN (1) | CN102803214A (es) |
AR (1) | AR077215A1 (es) |
AU (1) | AU2010264720A1 (es) |
BR (1) | BR112012000831A2 (es) |
CA (1) | CA2766696A1 (es) |
CL (1) | CL2011003079A1 (es) |
EA (1) | EA201200046A1 (es) |
IL (1) | IL216388A0 (es) |
MX (1) | MX2011013648A (es) |
NZ (1) | NZ596445A (es) |
TW (1) | TW201111361A (es) |
UY (1) | UY32731A (es) |
WO (1) | WO2010149684A1 (es) |
ZA (1) | ZA201108292B (es) |
Families Citing this family (13)
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AR077214A1 (es) * | 2009-06-24 | 2011-08-10 | Neurocrine Biosciences Inc | Heterociclos nitrogenados y composiciones farmaceuticas que los contienen |
NZ596445A (en) | 2009-06-24 | 2013-04-26 | Boehringer Ingelheim Int | New compounds, pharmaceutical composition and methods relating thereto |
JP6272695B2 (ja) | 2010-09-01 | 2018-01-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 体重管理のために有用な5−ht2cアゴニストの改変放出剤形 |
WO2012030938A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Salts of lorcaserin with optically active acids |
CN103189360A (zh) | 2010-09-01 | 2013-07-03 | 艾尼纳制药公司 | 5-ht2c激动剂的非吸湿性盐 |
CA2808900A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Fast-dissolve dosage forms of 5-ht2c agonists |
UY33805A (es) | 2010-12-17 | 2012-07-31 | Boehringer Ingelheim Int | ?Derivados de dihidrobenzofuranil-piperidinilo, aza-dihidrobenzofuranilpiperidinilo y diaza-dihidrobenzofuranil-piperidinilo, composiciones farmacéuticas que los contienen y usos de los mismos?. |
AR084905A1 (es) | 2011-01-21 | 2013-07-10 | Boehringer Ingelheim Int | Derivados de 2,3-dihidro-furo[2,3-c]piridina, composiciones farmaceuticas que los comprenden y su uso en el tratamiento de enfermedades mediadas por la activacion del receptor gpr119 acoplado a proteinas g |
EP2686312B1 (en) | 2011-03-14 | 2016-08-31 | Boehringer Ingelheim International GmbH | N-cyclopropyl-n-piperidinylbenzamides as gpr119 modulators |
WO2012168315A1 (en) | 2011-06-09 | 2012-12-13 | Boehringer Ingelheim International Gmbh | Substituted piperidines as gpr119 modulators for the treatment of metabolic disorders |
US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
JP6809464B2 (ja) * | 2015-08-06 | 2021-01-06 | 宇部興産株式会社 | 置換グアニジン誘導体 |
EP3564230B1 (en) | 2016-12-28 | 2022-02-09 | UBE Industries, Ltd. | Substituted guanidine compound |
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-
2010
- 2010-06-23 NZ NZ596445A patent/NZ596445A/xx not_active IP Right Cessation
- 2010-06-23 US US12/821,231 patent/US8293729B2/en active Active
- 2010-06-23 JP JP2012516706A patent/JP5467151B2/ja active Active
- 2010-06-23 MX MX2011013648A patent/MX2011013648A/es not_active Application Discontinuation
- 2010-06-23 BR BR112012000831A patent/BR112012000831A2/pt not_active IP Right Cessation
- 2010-06-23 AR ARP100102227A patent/AR077215A1/es unknown
- 2010-06-23 CA CA2766696A patent/CA2766696A1/en not_active Abandoned
- 2010-06-23 WO PCT/EP2010/058873 patent/WO2010149684A1/en active Application Filing
- 2010-06-23 EA EA201200046A patent/EA201200046A1/xx unknown
- 2010-06-23 CN CN2010800283693A patent/CN102803214A/zh active Pending
- 2010-06-23 EP EP10728189A patent/EP2445878A1/en not_active Withdrawn
- 2010-06-23 KR KR1020127001636A patent/KR20120046188A/ko not_active Application Discontinuation
- 2010-06-23 TW TW099120493A patent/TW201111361A/zh unknown
- 2010-06-23 AU AU2010264720A patent/AU2010264720A1/en not_active Abandoned
- 2010-06-24 UY UY0001032731A patent/UY32731A/es not_active Application Discontinuation
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2011
- 2011-11-11 ZA ZA2011/08292A patent/ZA201108292B/en unknown
- 2011-11-16 IL IL216388A patent/IL216388A0/en unknown
- 2011-12-05 CL CL2011003079A patent/CL2011003079A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2012530757A (ja) | 2012-12-06 |
US20110166116A1 (en) | 2011-07-07 |
IL216388A0 (en) | 2012-01-31 |
US8293729B2 (en) | 2012-10-23 |
EP2445878A1 (en) | 2012-05-02 |
CA2766696A1 (en) | 2010-12-29 |
WO2010149684A1 (en) | 2010-12-29 |
JP5467151B2 (ja) | 2014-04-09 |
ZA201108292B (en) | 2012-07-25 |
NZ596445A (en) | 2013-04-26 |
TW201111361A (en) | 2011-04-01 |
AR077215A1 (es) | 2011-08-10 |
BR112012000831A2 (pt) | 2019-09-24 |
KR20120046188A (ko) | 2012-05-09 |
EA201200046A1 (ru) | 2012-08-30 |
AU2010264720A1 (en) | 2011-12-08 |
CN102803214A (zh) | 2012-11-28 |
UY32731A (es) | 2011-01-31 |
CL2011003079A1 (es) | 2012-06-01 |
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