MX2010007374A - Nuevos derivados de c-21-ceto lupano, preparacion y uso de los mismos. - Google Patents

Nuevos derivados de c-21-ceto lupano, preparacion y uso de los mismos.

Info

Publication number
MX2010007374A
MX2010007374A MX2010007374A MX2010007374A MX2010007374A MX 2010007374 A MX2010007374 A MX 2010007374A MX 2010007374 A MX2010007374 A MX 2010007374A MX 2010007374 A MX2010007374 A MX 2010007374A MX 2010007374 A MX2010007374 A MX 2010007374A
Authority
MX
Mexico
Prior art keywords
keto
novel
derivatives preparation
sup
formula
Prior art date
Application number
MX2010007374A
Other languages
English (en)
Inventor
Christophe Moinet
Laval Chan Chun Kong
Liliane Halab
Marc Courchesne
Nathalie Chauret
Original Assignee
Virochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virochem Pharma Inc filed Critical Virochem Pharma Inc
Publication of MX2010007374A publication Critical patent/MX2010007374A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a compuestos 21-cetotriterpeno de formula (I): en donde R1, X e Y son como se define en la presente , y sales y solvatos de los mismos farmacéuticamente aceptables. Estos compuestos exhiben actividad anti-VIH significativa. Por lo siguiente la invención también se refiere a métodos para la prevención o tratamiento de infecciones por VIH administrando cantidades terapéuticamente efectivas de un compuesto de fórmula (I), o una sal o solvato del mismo farmacéuticamente aceptable a un sujeto en necesidad de tal tratamiento.
MX2010007374A 2008-01-03 2008-12-23 Nuevos derivados de c-21-ceto lupano, preparacion y uso de los mismos. MX2010007374A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1876608P 2008-01-03 2008-01-03
US3968008P 2008-03-26 2008-03-26
PCT/CA2008/002290 WO2009082818A1 (en) 2008-01-03 2008-12-23 Novel c-21-keto lupane derivatives preparation and use thereof

Publications (1)

Publication Number Publication Date
MX2010007374A true MX2010007374A (es) 2010-10-05

Family

ID=40823728

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010007374A MX2010007374A (es) 2008-01-03 2008-12-23 Nuevos derivados de c-21-ceto lupano, preparacion y uso de los mismos.

Country Status (7)

Country Link
EP (1) EP2240504A1 (es)
JP (1) JP2011508747A (es)
CN (1) CN101977924A (es)
AU (1) AU2008342536A1 (es)
CA (1) CA2711420A1 (es)
MX (1) MX2010007374A (es)
WO (1) WO2009082818A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2254582B1 (en) * 2008-01-25 2016-01-20 Chimerix, Inc. Methods of treating viral infections
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
DK3494972T3 (da) 2010-01-27 2024-01-29 Viiv Healthcare Co Kombinationer af dolutegravir og lamivudin til behandling af HIV-infektion
AU2011215986A1 (en) * 2010-02-11 2012-08-30 Glaxosmithkline Llc Derivatives of betulin
US9006218B2 (en) 2010-02-12 2015-04-14 Chimerix Inc. Nucleoside phosphonate salts
EP2563367A4 (en) 2010-04-26 2013-12-04 Chimerix Inc METHODS OF TREATING RETROVIRAL INFECTIONS AND ASSOCIATED DOSAGE REGIMES
WO2013020245A1 (en) * 2011-08-08 2013-02-14 Glaxosmithkline Llc Carbonyl derivatives of betulin
CN104844679B (zh) * 2011-12-16 2017-03-01 葛兰素史克有限责任公司 白桦脂醇的衍生物
JO3387B1 (ar) * 2011-12-16 2019-03-13 Glaxosmithkline Llc مشتقات بيتولين
CN103242413B (zh) * 2012-02-08 2015-08-26 江西青峰药业有限公司 Lupane三萜系衍生物及其药学用途
WO2014093941A1 (en) * 2012-12-14 2014-06-19 Glaxosmithkline Llc Pharmaceutical compositions
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
CN106999425A (zh) 2014-09-26 2017-08-01 葛兰素史克知识产权第二有限公司 长效药物组合物
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) * 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
WO2017115329A1 (en) * 2015-12-30 2017-07-06 Hetero Research Foundation C-3 novel triterpenone derivatives as hiv inhibitors
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Also Published As

Publication number Publication date
CA2711420A1 (en) 2009-07-09
CN101977924A (zh) 2011-02-16
WO2009082818A8 (en) 2009-09-03
WO2009082818A1 (en) 2009-07-09
EP2240504A1 (en) 2010-10-20
JP2011508747A (ja) 2011-03-17
AU2008342536A1 (en) 2009-07-09

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