MX2020011317A - Compuestos heterociclicos triciclicos utiles como inhibidores de la integrasa de vih. - Google Patents

Compuestos heterociclicos triciclicos utiles como inhibidores de la integrasa de vih.

Info

Publication number
MX2020011317A
MX2020011317A MX2020011317A MX2020011317A MX2020011317A MX 2020011317 A MX2020011317 A MX 2020011317A MX 2020011317 A MX2020011317 A MX 2020011317A MX 2020011317 A MX2020011317 A MX 2020011317A MX 2020011317 A MX2020011317 A MX 2020011317A
Authority
MX
Mexico
Prior art keywords
sup
tricyclic heterocycle
heterocycle compounds
compounds useful
hiv integrase
Prior art date
Application number
MX2020011317A
Other languages
English (en)
Inventor
Alan Whitehead
Yonglian Zhang
Tao Yu
James M Apgar
Zhiyong Hu
Valerie W Shurtleff
John A Mccauley
Izzat T Raheem
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2020011317A publication Critical patent/MX2020011317A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invención se refiere a compuestos heterocíclicos tricíclicos de la Fórmula (I): (ver Fórmula) y sales farmacéuticamente aceptables o profármaco de los mismos, en donde R1, R2, R3, R4, R5, R6 y n son como se definen en la presente. La presente invención también se refiere a composiciones que comprenden al menos un compuesto heterocíclico tricíclico y métodos para usar los compuestos heterocíclicos tricíclicos para tratar o prevenir la infección por VIH en un sujeto.
MX2020011317A 2018-04-27 2019-04-22 Compuestos heterociclicos triciclicos utiles como inhibidores de la integrasa de vih. MX2020011317A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862663377P 2018-04-27 2018-04-27
US201862664527P 2018-04-30 2018-04-30
PCT/US2019/028432 WO2019209667A1 (en) 2018-04-27 2019-04-22 Tricyclic heterocycle compounds useful as hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
MX2020011317A true MX2020011317A (es) 2020-11-18

Family

ID=68294232

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020011317A MX2020011317A (es) 2018-04-27 2019-04-22 Compuestos heterociclicos triciclicos utiles como inhibidores de la integrasa de vih.

Country Status (10)

Country Link
EP (1) EP3784241A4 (es)
JP (1) JP2021522254A (es)
KR (1) KR20210005139A (es)
CN (1) CN112088005A (es)
AU (1) AU2019260608A1 (es)
BR (1) BR112020021768A2 (es)
CA (1) CA3101180A1 (es)
MA (1) MA52367A (es)
MX (1) MX2020011317A (es)
WO (1) WO2019209667A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20201414A1 (es) 2018-05-31 2020-12-07 Shionogi & Co Derivado policiclico de piridona
US11649236B2 (en) 2018-05-31 2023-05-16 Shionogi & Co., Ltd. Polycyclic carbamoylpyridone derivative
EP3801543A4 (en) 2018-06-05 2022-03-02 Merck Sharp & Dohme Corp. HETEROCYCLIC TRICYCLIC COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS
WO2020197991A1 (en) 2019-03-22 2020-10-01 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
JP7441947B2 (ja) * 2019-11-26 2024-03-01 ギリアード サイエンシーズ， インコーポレイテッド Ｍｃｌ１阻害剤を調製するためのプロセス及び中間体
CR20220418A (es) 2020-02-24 2022-10-10 Gilead Sciences Inc Compuestos tetracíclicos para el tratamiento de infecciones por vih
HUE064467T2 (hu) 2021-01-19 2024-03-28 Gilead Sciences Inc Szubsztituált piridotriazin-származékok és alkalmazásuk

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2463975A1 (en) * 2001-10-26 2003-05-01 Maria Emilia Di Francesco Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
TW200510425A (en) * 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
US7902182B2 (en) * 2005-11-16 2011-03-08 Bristol-Myers Squibb Company HIV integrase inhibitors
HUE036384T2 (hu) * 2013-05-17 2018-07-30 Merck Sharp & Dohme Fúzionált triciklusos heterociklikus vegyületek mint HIV integráz inhibitorok
WO2017113288A1 (en) * 2015-12-31 2017-07-06 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors

Also Published As

Publication number Publication date
MA52367A (fr) 2021-03-03
AU2019260608A1 (en) 2020-10-29
WO2019209667A1 (en) 2019-10-31
EP3784241A4 (en) 2022-01-19
BR112020021768A2 (pt) 2021-01-26
EP3784241A1 (en) 2021-03-03
CA3101180A1 (en) 2019-10-31
CN112088005A (zh) 2020-12-15
JP2021522254A (ja) 2021-08-30
KR20210005139A (ko) 2021-01-13

Similar Documents

Publication Publication Date Title
MX2020011317A (es) Compuestos heterociclicos triciclicos utiles como inhibidores de la integrasa de vih.
TN2019000170A1 (en) Tetracyclic heterocycle compounds useful as hiv integrase inhibitors
TN2016000090A1 (en) Substituted quinolizine derivatives useful as hiv integrase inhibitors.
MX2021013075A (es) Oxisteroles y metodos de uso de los mismos.
MX2023001379A (es) Derivados de piperidin-1-il-n-piridina-3-il-2-oxoacet amida utiles para el tratamiento de canceres deficientes en mtap y/o que acumulan mt a.
MX2018008095A (es) Compuestos heterociclicos triciclicos condensados como inhibidores de integrasa del vih.
MX2019006449A (es) Compuestos heterociclicos triciclicos utiles como inhibidores de la integrasa del virus de inmunodeficiencia humana (vih).
MX2020011449A (es) Oxiesteroles y metodos de uso de los mismos.
MX371167B (es) Inhibidores de inhibidores del factor beta de crecimiento de transformacion (tgf-beta).
EP4316591A3 (en) Oxysterols and methods of use thereof
MX2010007375A (es) Nuevos derivados de lupano.
MX2020010690A (es) Oxiesteroles y metodos de uso de los mismos.
MX2010007374A (es) Nuevos derivados de c-21-ceto lupano, preparacion y uso de los mismos.
PH12017502009A1 (en) Novel sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection
WO2014172188A3 (en) 4-pyridone derivative compounds and uses thereof as hiv integrase inhibitors
MX2021004593A (es) Inhibidores de la replicacion del virus de la inmunodeficiencia humana.
MX2022004450A (es) Aminas de heteroaril-bifenilo para el tratamiento de enfermedades pd-l1.
MX2022004451A (es) Heteroaril-bifenil-amidas para el tratamiento de enfermedades relacionadas con el ligando pd-l1.
UY27577A1 (es) Inhibidores de la integrasa del vih
MX2021010700A (es) Compuestos utiles en la terapia del vih.
MX2021012105A (es) Compuestos de pirrol.
MX2021001804A (es) Compuestos de urea y composiciones como inhibidores de atpasa de smarca2/brm.
MX2023009445A (es) Compuestos de heterociclos tetraciclicos utiles como inhibidores de la integrasa del vih.
WO2020251871A3 (en) Novel substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
TW201129360A (en) Derivatives of pyridoxine for inhibiting HIV integrase