AR077214A1 - Heterociclos nitrogenados y composiciones farmaceuticas que los contienen - Google Patents
Heterociclos nitrogenados y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR077214A1 AR077214A1 ARP100102226A ARP100102226A AR077214A1 AR 077214 A1 AR077214 A1 AR 077214A1 AR P100102226 A ARP100102226 A AR P100102226A AR P100102226 A ARP100102226 A AR P100102226A AR 077214 A1 AR077214 A1 AR 077214A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- ralk
- independently
- heterocycle
- aryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Abstract
Compuestos para el tratamiento de varias afecciones relacionadas con el metabolismo en un paciente. También composiciones que contienen un compuesto en combinacion con un portador farmacéuticamente aceptable, así como métodos relacionados con su uso en un paciente que lo necesita. Reivindicacion 1: Un compuesto de la formula (1) en donde: X1, X2, X3 y X4 son, independientemente, -N- o -C(R5)-; Y1 e Y2 son, independientemente, -N- o -C(R3)-; A es -O- o -N(R7)-; R1 es RAlk, aril-alquilo C1-4, heterociclo-alquilo C1-4, -C(=O)R7, -CO2R6, -SO2R6, -C(=O)N(R7)2, -C(=S)N(R7)2, arilo o heterociclo, en donde cada Ralk, alquilo, arilo y heterociclo se sustituyen opcionalmente con 1 - 4 sustituyentes que se seleccionan, independientemente entre sí, de R9; R2, en cada caso, es independientemente alquilo C1-4, F, hidroxi o alquil C1-4-O-; R3, en cada caso, es independientemente H, halogeno, CN, alquilo C1-4, alquil C1-4-O- o alquil C1-4-S-; R4, en cada caso, es independientemente H, halogeno o alquilo C1-4; R5, en cada caso, es independientemente H, halogeno, ciano, hidroxi, RAlk, haloalquilo C1-4, -NO2, -C(O)R6, -CO2R6, -C(=O)N(R7)2, -SO2N(R7)2, -S(=O)R6, -S(=O)2R6, alquil C1-6-O-, haloalquil C1-4-O-, -N(R7)2, alquil C1-6-S-, arilo, aril-alquilo C1-6, heterociclo, heterociclo-alquilo C1-6, -NR7C(=O)R6, -NR7C(=O)N(R7)2, -NR7C(=O)OR7, -NR7C(=NR7)N(R7)2 o -NR7S(=O)2N(R7)2, en donde cada RAlk, alquilo, arilo y heterociclo se sustituyen, opcionalmente, con 1 - 5 sustituyentes que se seleccionan, independientemente entre sí, de R9; R6 es RAlk, heterociclo, heterociclo-alquilo C1-3 o arilo, en donde cada RAlk, alquilo, heterociclo y arilo se sustituyen, opcionalmente, con 1 - 4 sustituyentes que se seleccionan, independientemente entre sí, de R9; R7, en cada caso, es independientemente H o RAlk, en donde cada RAlk se sustituye, opcionalmente, con 1 - 4 sustituyentes que se seleccionan, independientemente entre sí, de halogeno, hidroxi, -N(R8)2, alquil C1-4-O- y -CO2R8; R8, en cada caso, es independientemente H o alquilo C1-4; R9, en cada caso, es independientemente ciano, hidroxi, RAlk, arilo, aril-alquilo C1-3, heterociclo, halogeno, oxo, haloalquilo C1-4, -NO2, -C(=O)H, -CO2R8, -OC(=O)RAlk, -C(=O)N(R7)2, -SO2N(R7)2, -S(=O)RAlk, S(=O)2RAlk, alcoxi C1-6, haloalcoxi C1-4, -N(R7)2, -SR7, -NR7C(=O)RAlk, -NR7C(=O)ORAlk o -NR7C(=O)N(R7)2, en donde cada RAlk, alquilo, arilo y heterociclo se sustituyen, opcionalmente, con 1 - 4 sustituyentes que se seleccionan, independientemente entre sí, de halogeno, hidroxi, -N(R8)2, alquil C1-4-O-, -NR7CO2R7, -NR7SO2R7 y -CO2R8; RAlk, en cada caso, es independientemente alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8, cicloalquil C3-8-alquilo C1-3, cicloalquenilo C4-8 o cicloalquenil C4-8-alquilo C1-3; m es 0, 1 o 2; n es 0, 1 o 2; p es 0 o 1; y q es 0, 1 o 2, incluso cualquier tautomero y estereoisomero de aquel, o una sal de aquel, o un solvato o hidrato de aquel.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22012509P | 2009-06-24 | 2009-06-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR077214A1 true AR077214A1 (es) | 2011-08-10 |
Family
ID=42712012
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100102226A AR077214A1 (es) | 2009-06-24 | 2010-06-23 | Heterociclos nitrogenados y composiciones farmaceuticas que los contienen |
Country Status (6)
Country | Link |
---|---|
US (1) | US8481731B2 (es) |
EP (1) | EP2445901A1 (es) |
JP (1) | JP2012530758A (es) |
AR (1) | AR077214A1 (es) |
TW (1) | TW201113269A (es) |
WO (1) | WO2010149685A1 (es) |
Families Citing this family (12)
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WO2010095663A1 (ja) * | 2009-02-18 | 2010-08-26 | 武田薬品工業株式会社 | 縮合複素環化合物 |
NZ596445A (en) | 2009-06-24 | 2013-04-26 | Boehringer Ingelheim Int | New compounds, pharmaceutical composition and methods relating thereto |
JP2012530758A (ja) | 2009-06-24 | 2012-12-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規化合物、医薬組成物及びそれに関する方法 |
KR20120130104A (ko) | 2010-02-01 | 2012-11-28 | 닛뽕 케미파 가부시키가이샤 | Gpr119 작동약 |
WO2012025811A1 (en) | 2010-08-23 | 2012-03-01 | Lupin Limited | Indolylpyrimidines as modulators of gpr119 |
CA2818050A1 (en) | 2010-11-26 | 2012-05-31 | Lupin Limited | Bicyclic gpr119 modulators |
UY33805A (es) | 2010-12-17 | 2012-07-31 | Boehringer Ingelheim Int | ?Derivados de dihidrobenzofuranil-piperidinilo, aza-dihidrobenzofuranilpiperidinilo y diaza-dihidrobenzofuranil-piperidinilo, composiciones farmacéuticas que los contienen y usos de los mismos?. |
JP5703393B2 (ja) | 2011-01-21 | 2015-04-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病、肥満および関連障害の治療のためのgpr119モジュレーターとしての縮合ジヒドロフラン |
JP5935154B2 (ja) | 2011-03-14 | 2016-06-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Gpr119モジュレーターとしてのn−シクロプロピル−n−ピペリジニルベンズアミド |
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KR20180004193A (ko) * | 2015-04-29 | 2018-01-10 | 아레나 파마슈티칼스, 인크. | Gpr52와 관련된 장애의 치료 또는 예방을 위한 gpr52 조절제로서 1-헤테로아릴-인돌린-4-카르복스아미드 |
TWI682707B (zh) * | 2017-02-24 | 2020-01-11 | 緯創資通股份有限公司 | 組裝組件及其組裝方法 |
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-
2010
- 2010-06-23 JP JP2012516707A patent/JP2012530758A/ja active Pending
- 2010-06-23 EP EP10725783A patent/EP2445901A1/en not_active Withdrawn
- 2010-06-23 AR ARP100102226A patent/AR077214A1/es unknown
- 2010-06-23 WO PCT/EP2010/058874 patent/WO2010149685A1/en active Application Filing
- 2010-06-23 TW TW099120497A patent/TW201113269A/zh unknown
- 2010-06-23 US US12/821,219 patent/US8481731B2/en active Active
Also Published As
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WO2010149685A1 (en) | 2010-12-29 |
US20110021491A1 (en) | 2011-01-27 |
US8481731B2 (en) | 2013-07-09 |
JP2012530758A (ja) | 2012-12-06 |
TW201113269A (en) | 2011-04-16 |
EP2445901A1 (en) | 2012-05-02 |
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