AR080074A1 - Naftiridinas sustituidas y su uso como medicamentos - Google Patents
Naftiridinas sustituidas y su uso como medicamentosInfo
- Publication number
- AR080074A1 AR080074A1 ARP110100305A AR080074A1 AR 080074 A1 AR080074 A1 AR 080074A1 AR P110100305 A ARP110100305 A AR P110100305A AR 080074 A1 AR080074 A1 AR 080074A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- nr9r10
- alkylene
- hydrogen
- individually selected
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
Composiciones farmacéuticas que contienen estos compuestos, y usos de los mismos. Reivindicacion 1: Un compuesto caracterizado porque tiene la formula (1) en la que R1 se selecciona entre -O-R3 o -NR3R4 donde R3 es alquilo C1-6 sustituido con R5 y R6 donde R5 se selecciona entre hidrogeno, alquilo C1-6 lineal o ramificado, alquenilo C2-6, -alquilen C1-6-O-alquilo C1-3, haloalquilo C1-3, donde R6 es un anillo X de formula (2); donde n es 0 o 1, donde es o bien un enlace sencillo o un doble enlace y donde A, B, D y E se seleccionan cada uno independientemente entre CH2, CH, C, N, NH, O o S y donde el anillo X se adjunta a la molécula mediante la posicion A, B, D o E, donde dicho anillo X puede estar opcionalmente sustituido con uno, dos o tres residuos seleccionados cada uno individualmente entre el grupo que consiste en -oxo, hidroxi, -alquilo C1-3, -haloalquilo C1-3, -O-alquilo C1-3, -alcanol C1-3 y halogeno, R4 se selecciona entre el grupo que consiste en hidrogeno y alquilo C1-6, R2 se selecciona entre el grupo que consiste en hidrogeno; arilo de 5 a 10 miembros; heteroarilo de 5 a 10 miembros que comprende 1, 2 o 3 heteroátomos cada uno individualmente seleccionado entre N, O y S; heterociclo saturado o parcialmente insaturado de 5 a 10 miembros que comprende 1, 2 o 3 heteroátomos cada uno individualmente seleccionado entre N, O y S; cicloalquilo saturado o parcialmente insaturado de 3 a 10 miembros, donde - en caso de que R2 no sea hidrogeno - dicho R2 puede estar opcionalmente sustituido con 1, 2, 3 o 4 residuos, cada uno individualmente seleccionado entre el grupo que consiste en hidrogeno, -oxo, halogeno, -alquilo C1-6, -alquenilo C2-6, -alquilen C1-6-COOH, -COOH, -CO-NR9R10, -alquilen C1-6-CO-NR9R10, -alquilen C1-6-NR9R10, -alquilen C1-6-CO-Q, -CO-Q, -alquilen C1-6-CO-NR9Q, -CO-NR9Q, -alquilen C1-6-NR11-CO-NR9R10, -alquilen C1-6-NR11-CO-Q, -alquilen C1-6-NR11-SO2R9, -alquilen C1-6-O-CO-R9, -alquilen C1-6-O-CO-NR9R10, -alquilen C1-6-O-R9, -alquilen C1-6-SO-NR9R10, -alquilen C1-6-SO2R9, -alquilen C1-6-SOR9, -alquinilen C1-6-O-R9, -alquinilen C1-6-Q, -alquinilen C1-6-NR9R10, arilo C5-10, -Q, -cicloalquilo C3-8, -O-R7, -O-alquilen C1-6-R7, -O-alquilen C1-6-O-R7, -haloalquilo C1-3, cianuro, -NR11R7, -NR11(alquilen C1-6-R7), -S(O)-alquilo C1-6, -SO2-alquilo C1-6, -S-alquilo C1-6, -SO2-NR9R10, -SO2-NR11Q, heteroarilo de 5 a 10 miembros que comprende 1, 2 o 3 heteroátomos cada uno individualmente seleccionado entre N, O y S, -NR11-CO-R7 y -O-CO-R7, donde R7 se selecciona del grupo que consiste en hidrogeno; alquilo C1-6 lineal o ramificado; -haloalquilo C1-6; -alquilen C1-6-COOH; -alquilen C1-6-CO-NR9R10; -alquilen C1-6-CO-Q; -alquilen C2-6-NR11-CO-NR9R10; -alquilen C2-6-NR11-CO-Q; -alquilen C2-6-NR11-SO2R9; -alquilen C2-6-NR9R10; -alquilen C2-6-Q; -alquilen C2-6-O-CO-R9, -alquilen C2-6-O-CO-NR9R10, -alquilen C2-6-SO-NR9R10, -alquilen C2-6-SO2-R9, -alquilen C2-6-SO-R9, -SO2-R9, -SO-R9, -SO2-NR9R10, -SO2-NR11Q, -SO2-Q, -alquilen C1-6-O-R9 -CO-NR9R10, -CONR9Q, -CO-R9, -CO-Q, -alquilen C1-6-Q, -arilo C5-10, -Q, cicloalquilo saturado o parcialmente insaturado de 3 a 8 miembros; heteroarilo de 5 a 10 miembros que comprende 1, 2 o 3 heteroátomos cada uno individualmente seleccionado entre N, O y S; -alquilen C1-6-heteroarilo, donde este heteroarilo tiene 5 a 10 miembros y comprende 1, 2 o 3 heteroátomos cada uno individualmente seleccionado entre N, O y S; donde - en caso de que R7 no sea hidrogeno - R7 puede estar opcionalmente sustituido con 1, 2 o 3 residuos R8 que se seleccionan individualmente entre el grupo que consiste en hidrogeno; -oxo; hidroxi; -alquilo C1-6; -haloalquilo C1-6; -NR9R10 , -Q, -NR9Q, cicloalquilo saturado o parcialmente insaturado de 3 a 6 miembros; donde - en caso de que R8 no sea hidrogeno - R8 puede estar opcionalmente sustituido con 1, 2 o 3 residuos seleccionados entre hidrogeno, -oxo, -hidroxi, -alquilo C1-6, halogeno, -haloalquilo C1-6, -O-alquilo C1-6, -alquilen C1-3-O-alquilo C1-3, donde cada uno de R9, R1° y R11 se selecciona individualmente uno de otro del grupo que consiste en hidrogeno, -alquilo C1-6, -cicloalquilo C3-8, -alquil C1-6-cicloalquilo C3-8 y fenilo, y donde cada Q se selecciona individualmente o bien de un heterociclo saturado o parcialmente insaturado de 5 a 10 miembros o de un heterociclo parcialmente insaturado que comprende 1, 2 o 3 heteroátomos cada uno individualmente seleccionado entre N, O o S, o entre un heteroarilo de 5 a 10 miembros que comprende 1, 2 o 3 heteroátomos cada uno individualmente seleccionado entre N, O y S; donde Q está unido al resto de la molécula o bien mediante un átomo de carbono o mediante un átomo de nitrogeno, los N-oxidos de los compuestos anteriormente mencionados, particularmente los 1-naftiridinil-oxidos de los compuestos previamente mencionados, y las sales farmacéuticamente aceptables de los compuestos anteriormente mencionados.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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EP10152159 | 2010-01-29 |
Publications (1)
Publication Number | Publication Date |
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AR080074A1 true AR080074A1 (es) | 2012-03-14 |
Family
ID=42272624
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP110100305 AR080074A1 (es) | 2010-01-29 | 2011-01-28 | Naftiridinas sustituidas y su uso como medicamentos |
Country Status (18)
Country | Link |
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US (2) | US8969568B2 (es) |
EP (1) | EP2528915B1 (es) |
JP (1) | JP5629331B2 (es) |
KR (1) | KR20120125267A (es) |
CN (1) | CN102822172A (es) |
AR (1) | AR080074A1 (es) |
AU (1) | AU2011209274B8 (es) |
BR (1) | BR112012018865A2 (es) |
CA (1) | CA2786245A1 (es) |
CL (1) | CL2012001807A1 (es) |
EA (1) | EA201201052A1 (es) |
IL (1) | IL220553A0 (es) |
MX (1) | MX2012008533A (es) |
NZ (1) | NZ600857A (es) |
TW (1) | TW201139435A (es) |
UY (1) | UY33205A (es) |
WO (1) | WO2011092128A1 (es) |
ZA (1) | ZA201204793B (es) |
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US8604049B2 (en) | 2008-08-05 | 2013-12-10 | Boehringer Ingelheim International Gmbh | 4-dimethylamino-phenyl-substituted naphthyridines, and use thereof as medicaments |
JP5629331B2 (ja) | 2010-01-29 | 2014-11-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換ナフチリジン及びsykキナーゼ阻害剤としてのその使用 |
WO2012167423A1 (en) | 2011-06-08 | 2012-12-13 | Hutchison Medipharma Limited | Substituted pyridopyrazines as novel syk inhibitors |
CA2843022C (en) | 2011-07-26 | 2019-09-24 | Boehringer Ingelheim International Gmbh | Substituted quinolines and their use as medicaments |
US20150307491A1 (en) * | 2012-12-07 | 2015-10-29 | Hutchison Medipharma Limited | Substituted pyridopyrazines as syk inhibitors |
CN104812753A (zh) * | 2012-12-07 | 2015-07-29 | 和记黄埔医药(上海)有限公司 | 作为Syk抑制剂的取代吡啶并吡嗪类化合物 |
US9212178B2 (en) | 2013-10-21 | 2015-12-15 | Genosco | Substituted pyrimidine compounds and their use as SYK inhibitors |
CN110183440B (zh) | 2014-03-19 | 2022-04-22 | 勃林格殷格翰国际有限公司 | 杂芳基syk抑制剂 |
WO2017042100A1 (en) | 2015-09-11 | 2017-03-16 | Boehringer Ingelheim International Gmbh | Pyrazolyl-substituted heteroaryls and their use as medicaments |
SI3364958T1 (sl) * | 2015-10-23 | 2023-05-31 | Navitor Pharmaceuticals, Inc. | Modulatorji interakcije sestrina in gator2 ter njihova uporaba |
US11633399B2 (en) | 2018-12-25 | 2023-04-25 | Sol-Gel Technologies Ltd. | Treatment of skin disorders with compositions comprising an EGFR inhibitor |
WO2020188015A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
AU2020378630A1 (en) | 2019-11-08 | 2022-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
CN114315747A (zh) * | 2020-09-30 | 2022-04-12 | 山东润博生物科技有限公司 | 一种5,5-二甲基异噁唑烷-3-硫酮的制备方法 |
KR20220138655A (ko) * | 2021-04-06 | 2022-10-13 | 주식회사 온코크로스 | 신장 질환의 예방 또는 치료용 화합물 |
KR20220138654A (ko) * | 2021-04-06 | 2022-10-13 | 주식회사 온코크로스 | 당뇨병의 예방 또는 치료용 화합물 |
CN113735791A (zh) * | 2021-10-14 | 2021-12-03 | 杭州欧晨科技有限公司 | 一种3-溴-5,5-二甲基-4,5-二氢异噁唑的合成方法 |
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-
2011
- 2011-01-21 JP JP2012550404A patent/JP5629331B2/ja active Active
- 2011-01-21 EA EA201201052A patent/EA201201052A1/ru unknown
- 2011-01-21 EP EP11700849.0A patent/EP2528915B1/en active Active
- 2011-01-21 MX MX2012008533A patent/MX2012008533A/es not_active Application Discontinuation
- 2011-01-21 BR BR112012018865A patent/BR112012018865A2/pt not_active IP Right Cessation
- 2011-01-21 CN CN2011800165422A patent/CN102822172A/zh active Pending
- 2011-01-21 KR KR20127019984A patent/KR20120125267A/ko not_active Application Discontinuation
- 2011-01-21 CA CA 2786245 patent/CA2786245A1/en not_active Abandoned
- 2011-01-21 WO PCT/EP2011/050871 patent/WO2011092128A1/en active Application Filing
- 2011-01-21 NZ NZ60085711A patent/NZ600857A/en not_active IP Right Cessation
- 2011-01-21 AU AU2011209274A patent/AU2011209274B8/en not_active Expired - Fee Related
- 2011-01-26 US US13/013,973 patent/US8969568B2/en active Active
- 2011-01-28 UY UY33205A patent/UY33205A/es not_active Application Discontinuation
- 2011-01-28 TW TW100103483A patent/TW201139435A/zh unknown
- 2011-01-28 AR ARP110100305 patent/AR080074A1/es unknown
-
2012
- 2012-06-21 IL IL220553A patent/IL220553A0/en unknown
- 2012-06-27 ZA ZA2012/04793A patent/ZA201204793B/en unknown
- 2012-07-04 CL CL2012001807A patent/CL2012001807A1/es unknown
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2015
- 2015-01-08 US US14/592,301 patent/US9187478B2/en active Active
Also Published As
Publication number | Publication date |
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JP2013518073A (ja) | 2013-05-20 |
AU2011209274B8 (en) | 2015-08-13 |
CA2786245A1 (en) | 2011-08-04 |
US20120028939A1 (en) | 2012-02-02 |
IL220553A0 (en) | 2012-08-30 |
BR112012018865A2 (pt) | 2016-04-12 |
US8969568B2 (en) | 2015-03-03 |
MX2012008533A (es) | 2012-08-31 |
CN102822172A (zh) | 2012-12-12 |
UY33205A (es) | 2011-08-31 |
TW201139435A (en) | 2011-11-16 |
US20150126503A1 (en) | 2015-05-07 |
WO2011092128A1 (en) | 2011-08-04 |
AU2011209274A8 (en) | 2015-08-13 |
NZ600857A (en) | 2014-06-27 |
ZA201204793B (en) | 2013-02-27 |
EP2528915B1 (en) | 2015-10-28 |
AU2011209274A1 (en) | 2012-07-19 |
US9187478B2 (en) | 2015-11-17 |
EA201201052A1 (ru) | 2013-02-28 |
JP5629331B2 (ja) | 2014-11-19 |
AU2011209274B2 (en) | 2015-07-16 |
EP2528915A1 (en) | 2012-12-05 |
CL2012001807A1 (es) | 2012-10-12 |
KR20120125267A (ko) | 2012-11-14 |
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