EA201201052A1 - Замещенные нафтиридины и их применение в качестве ингибиторов киназы syk - Google Patents

Замещенные нафтиридины и их применение в качестве ингибиторов киназы syk

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Publication number
EA201201052A1
EA201201052A1 EA201201052A EA201201052A EA201201052A1 EA 201201052 A1 EA201201052 A1 EA 201201052A1 EA 201201052 A EA201201052 A EA 201201052A EA 201201052 A EA201201052 A EA 201201052A EA 201201052 A1 EA201201052 A1 EA 201201052A1
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EA
Eurasian Patent Office
Prior art keywords
alkyl
substituted
group
ring
naftyridine
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EA201201052A
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English (en)
Inventor
Маттиас Хоффманн
Георг Даманн
Деннис Фиген
Зандра Хандшух
Ясна Клициц
Гюнтер Линц
Герхард Шенцле
Андреас Шнапп
Стивен П. Ист
Михаэль Филип Мацанетц
Роберт Джон Скотт
Эдуард Уолкер
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Бёрингер Ингельхайм Интернациональ Гмбх
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Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201201052A1 publication Critical patent/EA201201052A1/ru

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Abstract

В заявке описаны новые замещенные нафтиридины формулы 1, а также их фармакологически приемлемые соли, диастереоизомеры, энантиомеры, рацематы, гидраты или сольватыв которой Rвыбран из группы, включающей -O-Rили -NRR, Rобозначает C-C-алкил, который замещен с помощью Rи R, Rвыбран из группы, включающей водород, разветвленный или линейный C-C-алкил, C-C-алкенил, -C-C-алкилен-О-C-C-алкил, C-C-галогеналкил, Rобозначает кольцо Xв котором n равно 0 или 1, иобозначает ординарную или двойную связь и в котором А, В, D, где кольцо X присоединено к молекуле в положении А, В, D или Е, где указанное кольцо X необязательно может быть дополнительно замещено 1, 2 или 3 остатками, каждый из которых по отдельности выбран из группы, включающей -оксогруппу, гидроксигруппу, -C-C-алкил, -C-C-галогеналкил, -O-C-C-алкил, -C-C-алканол и галоген, и где R, R, R, R, R, R, Rи Q могут обладать значениями, приведенными в п.1 формулы изобретения, а также фармацевтические композиции, содержащие эти соединения.
EA201201052A 2010-01-29 2011-01-21 Замещенные нафтиридины и их применение в качестве ингибиторов киназы syk EA201201052A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10152159 2010-01-29
PCT/EP2011/050871 WO2011092128A1 (en) 2010-01-29 2011-01-21 Substituted naphthyridines and their use as syk kinase inhibitors

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EA201201052A1 true EA201201052A1 (ru) 2013-02-28

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US (2) US8969568B2 (ru)
EP (1) EP2528915B1 (ru)
JP (1) JP5629331B2 (ru)
KR (1) KR20120125267A (ru)
CN (1) CN102822172A (ru)
AR (1) AR080074A1 (ru)
AU (1) AU2011209274B8 (ru)
BR (1) BR112012018865A2 (ru)
CA (1) CA2786245A1 (ru)
CL (1) CL2012001807A1 (ru)
EA (1) EA201201052A1 (ru)
IL (1) IL220553A0 (ru)
MX (1) MX2012008533A (ru)
NZ (1) NZ600857A (ru)
TW (1) TW201139435A (ru)
UY (1) UY33205A (ru)
WO (1) WO2011092128A1 (ru)
ZA (1) ZA201204793B (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8604049B2 (en) 2008-08-05 2013-12-10 Boehringer Ingelheim International Gmbh 4-dimethylamino-phenyl-substituted naphthyridines, and use thereof as medicaments
NZ600857A (en) 2010-01-29 2014-06-27 Boehringer Ingelheim Int Substituted naphthyridines and their use as syk kinase inhibitors
WO2012167423A1 (en) 2011-06-08 2012-12-13 Hutchison Medipharma Limited Substituted pyridopyrazines as novel syk inhibitors
MX336224B (es) 2011-07-26 2016-01-12 Boehringer Ingelheim Int Quinolinas sustituidas y su uso como medicamentos.
WO2014086032A1 (en) * 2012-12-07 2014-06-12 Hutchison Medipharma Limited Substituted pyridopyrazines as syk inhibitors
CN104812753A (zh) * 2012-12-07 2015-07-29 和记黄埔医药（上海）有限公司 作为Syk抑制剂的取代吡啶并吡嗪类化合物
JP6434506B2 (ja) 2013-10-21 2018-12-05 ジェノスコ 置換ピリミジン化合物およびｓｙｋ阻害剤としてのそれらの使用
EP3119765B1 (en) * 2014-03-19 2019-07-17 Boehringer Ingelheim International GmbH Heteroaryl syk inhibitors
EP3347353B1 (en) 2015-09-11 2019-07-17 Boehringer Ingelheim International GmbH Pyrazolyl-substituted heteroaryls and their use as medicaments
HUE061437T2 (hu) * 2015-10-23 2023-06-28 Navitor Pharm Inc A Sestrin-GATOR2 kölcsönhatás modulátorai és ezek alkalmazásai
US11633399B2 (en) 2018-12-25 2023-04-25 Sol-Gel Technologies Ltd. Treatment of skin disorders with compositions comprising an EGFR inhibitor
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
US20220401436A1 (en) 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN114315747A (zh) * 2020-09-30 2022-04-12 山东润博生物科技有限公司 一种5,5-二甲基异噁唑烷-3-硫酮的制备方法
KR20220138654A (ko) * 2021-04-06 2022-10-13 주식회사 온코크로스 당뇨병의 예방 또는 치료용 화합물
KR20220138655A (ko) * 2021-04-06 2022-10-13 주식회사 온코크로스 신장 질환의 예방 또는 치료용 화합물
CN113735791A (zh) * 2021-10-14 2021-12-03 杭州欧晨科技有限公司 一种3-溴-5,5-二甲基-4,5-二氢异噁唑的合成方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4017500A (en) 1973-07-16 1977-04-12 Schering Corporation Certain 8-amino-1,7-naphthyridines
US4260759A (en) 1969-04-14 1981-04-07 Schering-Corporation Process for preparing 1-aminonaphthyridines
US3928367A (en) 1969-04-14 1975-12-23 Schering Corp 1-Amino naphthyridines
US4115395A (en) 1975-11-12 1978-09-19 Schering Corporation 1-Aminonaphthyridines
DE3027619A1 (de) 1979-07-25 1981-02-19 Sandoz Ag 6-alkyl-7-phenyl-1,6-naphtyradin- 5(6h)-on-derivate
US4329349A (en) 1979-07-25 1982-05-11 Sandoz, Inc. 6-C1-4 Alkyl-7-phenyl or substituted phenyl-1,6-naphthyridine-5(6H)-ones
ATE404539T1 (de) 1997-10-02 2008-08-15 Eisai R&D Man Co Ltd Kondensierte pyridinderivate
WO2001052902A1 (en) 2000-01-24 2001-07-26 Isis Pharmaceuticals, Inc. Antisense modulation of inducible nitric oxide synthase expression
GB0004153D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel use
AR035851A1 (es) 2000-03-28 2004-07-21 Wyeth Corp 3-cianoquinolinas, 3-ciano-1,6-naftiridinas y 3-ciano-1,7-naftiridinas como inhibidoras de proteina quinasas
MEP40008A (en) 2000-10-12 2011-02-10 Boehringer Ingelheim Pharma Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
AR035700A1 (es) 2001-05-08 2004-06-23 Astrazeneca Ab Derivados de arilheteroalquilamina, composicion farmaceutica, usos de estos derivados para la fabricacion de medicamentos, metodos de tratamiento, y proceso para la preparacion de estos derivados
EP1396488A1 (en) * 2001-05-23 2004-03-10 Mitsubishi Pharma Corporation Fused heterocyclic compound and medicinal use thereof
RS50441B (sr) 2001-06-22 2010-03-02 Boehringer Ingelheim Pharma Gmbh. & Co.Kg. Kristalni antiholinergik, postupak za njegovo pripremanje i njegova primena u proizvodnji leka
DE10292982D2 (de) * 2001-07-04 2004-07-01 Braincom Ag Flächenheizung, Verfahren zu deren Herstellung und heizbarer Gegenstand sowie Sitzbelegungserkennung, Sitz damit und Sitzbelegungserkennungsverfahren
US20030158195A1 (en) 2001-12-21 2003-08-21 Cywin Charles L. 1,6 naphthyridines useful as inhibitors of SYK kinase
SE0203304D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Coumpounds
ES2211344B1 (es) * 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
JP2006519846A (ja) 2003-03-10 2006-08-31 シェーリング　コーポレイション 複素環式キナーゼインヒビター：使用および合成の方法
CL2004000985A1 (es) 2003-05-16 2005-01-14 Wyeth Corp Compuestos derivados de fenilquinolinas; composicion farmaceutica, proceso de preparacion; y uso para tratar osteoporosis, enfermedad de paget, dano vascular, osteoartritis, cancer oseo, cancer ovarico, cancer prostatico, hipercolesterolemia, aterosc
CA2542105C (en) 2003-10-08 2011-08-02 Irm Llc Compounds and compositions as protein kinase inhibitors
EP1781293A1 (en) 2004-06-04 2007-05-09 Amphora Discovery Corporation Quinoline- and isoquinoline-based compounds exhibiting atp-utilizing enzyme inhibitory activity, and compositions, and uses thereof
WO2008051757A1 (en) 2006-10-20 2008-05-02 Irm Llc Compositions and methods for modulating c-kit and pdgfr receptors
EP2094276A4 (en) * 2006-12-20 2011-01-05 Abbott Lab ANTIVIRAL COMPOUNDS
US8053440B2 (en) * 2007-02-01 2011-11-08 Resverlogix Corporation Compounds for the prevention and treatment of cardiovascular diseases
JP5377332B2 (ja) 2007-02-06 2013-12-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 二環式へテロ環、それらの化合物を含む薬剤、その使用及びその製法
WO2009038412A2 (en) 2007-09-21 2009-03-26 Lg Life Sciences, Ltd. Beta-secretase inhibiting compounds
MX2010003001A (es) 2007-09-27 2010-04-01 Hoffmann La Roche Derivados de quinolina como antagonistas del receptor de la 5-hidroxitriptamina 5a.
US8604049B2 (en) 2008-08-05 2013-12-10 Boehringer Ingelheim International Gmbh 4-dimethylamino-phenyl-substituted naphthyridines, and use thereof as medicaments
EP2324022A1 (de) 2008-08-05 2011-05-25 Boehringer Ingelheim International GmbH Substituierte naphthyridine und ihre verwendung als arzneimittel
FR2949465B1 (fr) 2009-09-01 2011-08-12 Pf Medicament Derives chromones, leur procede de preparation et leurs applications therapeutiques
NZ600857A (en) 2010-01-29 2014-06-27 Boehringer Ingelheim Int Substituted naphthyridines and their use as syk kinase inhibitors
EP2527344A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases
MX336224B (es) 2011-07-26 2016-01-12 Boehringer Ingelheim Int Quinolinas sustituidas y su uso como medicamentos.
EP2736900A1 (en) 2011-07-26 2014-06-04 Grünenthal GmbH Substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands

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BR112012018865A2 (pt) 2016-04-12
CL2012001807A1 (es) 2012-10-12
EP2528915A1 (en) 2012-12-05
ZA201204793B (en) 2013-02-27
US20120028939A1 (en) 2012-02-02
MX2012008533A (es) 2012-08-31
CA2786245A1 (en) 2011-08-04
AU2011209274A1 (en) 2012-07-19
WO2011092128A1 (en) 2011-08-04
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JP2013518073A (ja) 2013-05-20
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